LOCUS 036_IIG_Bs27_018_SNP 3526829 bp DNA circular UNA 12-JAN-2021 DEFINITION Bacillus subtilis strain Delta6 (hybrid trycycler assembly). ACCESSION urn.local...1ej-cvskbtm VERSION urn.local...1ej-cvskbtm KEYWORDS . SOURCE ORGANISM . FEATURES Location/Qualifiers S_feature complement(3526719..658) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" CDS 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" /label="dnaA CDS" gene 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /label="dnaA gene" promotor_-10 complement(631..649) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(665..670) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1342..1529 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" /label="dnaN CDS" gene 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /label="dnaN gene" downshifts 2650 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" promotor_-35 2731..2735 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752..2771 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" /label="rlbA CDS" gene 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /label="rlbA gene" CDS 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" /label="recF CDS" gene 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /label="recF gene" misc_feature 3226..3245 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3244 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" /label="remB CDS" gene 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /label="remB gene" CDS 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" /label="gyrB CDS" gene 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /label="gyrB gene" promotor_-10 complement(6003..6021) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6005) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(6037..6042) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6375..6584 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" /label="gyrA CDS" gene 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /label="gyrA gene" promotor_-35 8964..8967 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 8965 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 8984..9001 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9031 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 9095..9101 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9115..9134 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9120..9205 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9120 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 9191..9198 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9207 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 9213..9232 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-16S rRNA" gene 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /label="rrnO-16S gene" tRNA 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ile tRNA" gene 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /label="trnO-Ile gene" tRNA 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ala tRNA" gene 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /label="trnO-Ala gene" rRNA 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-23S rRNA" gene 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /label="rrnO-23S gene" rRNA 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-5S rRNA" gene 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /label="rrnO-5S gene" S_feature 14402..15459 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" /label="yaaC CDS" gene complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /label="yaaC gene" promotor_-35 15438..15445 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15460..15479 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15461 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(15466) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(15475..15486) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15500..15506) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" /label="guaB CDS" gene 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /label="guaB gene" downshifts complement(15510) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(15536..15636) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15576) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(16829..17424) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 16960 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 17018..17022 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17038..17057 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17044..17124 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17044 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" /label="dacA CDS" gene 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /label="dacA gene" promotor_-10 complement(17413..17431) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17424) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(17446..17452) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18338 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" /label="downshifts" S_feature 18457..18565 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18535..18538 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18553..18572 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18567..18652 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18567 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" /label="pdxS CDS" gene 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /label="pdxS gene" S_feature complement(18785..19514) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19502..19520) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19514) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(19536..19541) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" /label="pdxT CDS" gene 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /label="pdxT gene" misc_RNA 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboS RNA" gene 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /label="tboS gene" downshifts 20379 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" /label="downshifts" CDS 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" /label="serS CDS" gene 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /label="serS gene" downshifts 21726 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 21837..21844 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 21859..21878 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 21859 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="upshifts" tRNA 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Ser1 tRNA" gene 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /label="trnSL-Ser1 gene" downshifts 21998 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" /label="downshifts" S_feature 22043..22120 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " /label="dck CDS" gene complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /label="dck gene" promotor_-35 22106..22112 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22111) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 22122..22758 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22122 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 22126..22137 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" /label="dgk CDS" gene complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /label="dgk gene" promotor_-10 complement(23401..23420) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23419) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(23436..23440) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" /label="sleL CDS" gene complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /label="sleL gene" downshifts complement(23496) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(24773..24791) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(24794) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(24807..24812) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" /label="yaaI CDS" gene complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /label="yaaI gene" promotor_-35 25223..25227 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25242..25261 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25246..25442 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25248 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" promotor_-10 complement(25382..25400) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25401) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(25415..25421) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" /label="tadA CDS" gene 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /label="tadA gene" promotor_-35 25932..25938 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25952..25971 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" /label="scr RNA" gene 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /label="scr gene" S_feature 25974..26123 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 25974 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" S_feature 26227..26322 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26279 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 26343..26346 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26370 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" /label="dnaX CDS" gene 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /label="dnaX gene" promotor_-35 27937..27944 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 27959..27978 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 27974 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" /label="ebfC CDS" gene 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /label="ebfC gene" CDS 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" /label="recR CDS" gene 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /label="recR gene" CDS 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" /label="yaaL CDS" gene 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /label="yaaL gene" promotor_-35 29299..29304 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29316 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="upshifts" promotor_-10 29320..29338 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" /label="bofA CDS" gene 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /label="bofA gene" promotor_-35 29639..29646 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 29660..29679 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 29667..29869 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 29667 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-16S" gene 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /label="rrnA-16S gene" tRNA 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ile" gene 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /label="trnA-Ile gene" tRNA 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ala" gene 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /label="trnA-Ala gene" rRNA 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-23S" gene 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /label="rrnA-23S gene" S_feature 34695..34827 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-5S" gene 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /label="rrnA-5S gene" S_feature 34947..35049 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35010..35018 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35032..35051 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35051 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="upshifts" CDS 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" /label="csfB CDS" gene 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /label="csfB gene" downshifts 35300 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" /label="downshifts" promotor_-35 35361..35370 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35382..35397 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35388 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" /label="xpaC CDS" gene 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /label="xpaC gene" CDS 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" /label="yaaN CDS" gene 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /label="yaaN gene" S_feature 37230..37310 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" /label="yaaO CDS" gene 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /label="yaaO gene" promotor_-35 38673..38679 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 38694..38712 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 38703 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="upshifts" CDS 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" /label="tmk CDS" gene 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /label="tmk gene" promotor_-35 39383..39390 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39403..39422 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39414 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" /label="darA CDS" gene 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /label="darA gene" CDS 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" /label="yaaR CDS" gene 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /label="yaaR gene" CDS 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" /label="holB CDS" gene 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /label="holB gene" CDS 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " /label="ricT CDS" gene 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /label="ricT gene" CDS 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" /label="dnaH CDS" gene 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /label="dnaH gene" CDS 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" /label="trmNF CDS" gene 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /label="trmNF gene" CDS 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" /label="yazA CDS" gene 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /label="yazA gene" CDS 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" /label="rsmI CDS" gene 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /label="rsmI gene" downshifts 44363 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" /label="abrB CDS" gene complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /label="abrB gene" downshifts complement(44441) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 44760 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(44796..44815) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(44813) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(44815..44990) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(44829..44836) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(44986..45005) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(44990) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="upshifts" promotor_-35 complement(45019..45026) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45090..45094 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45109..45128 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45115..45223 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45115 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="upshifts" CDS 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" /label="metS CDS" gene 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /label="metS gene" promotor_-10 complement(45972..45991) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45980) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(46007..46011) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47202 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" S_feature complement(47264..49610) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" /label="dayD CDS" gene 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /label="dayD gene" S_feature 48065..48145 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48122..48127 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48143..48161 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48147 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 48172..48175 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48190..48209 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48207 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="upshifts" CDS 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" /label="yabE CDS" gene 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /label="yabE gene" promotor_-35 48240..48247 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48258 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 48262..48281 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49494 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-35 49556..49560 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49576..49595 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49578..49677 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49578 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(49602..49617) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(49618) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(49629..49638) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 49674..49690 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" /label="rnmV CDS" gene 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /label="rnmV gene" upshifts 49688 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" CDS 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" /label="rsmA CDS" gene 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /label="rsmA gene" downshifts 51074 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 51124..51133 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51147..51166 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51149..51270 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51149 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="upshifts" CDS 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" /label="prtG CDS" gene 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /label="prtG gene" downshifts 52130 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 52240..52310 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52301..52308 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52312 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 52322..52341 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52331..52345) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52338) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(52354..52358) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" /label="veg CDS" gene 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /label="veg gene" downshifts 52526 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" /label="downshifts" downshifts 52613 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" /label="downshifts" promotor_-35 52679..52685 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 52699..52710 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 52702..52773 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 52702 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="upshifts" CDS 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" /label="sspF CDS" gene 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /label="sspF gene" downshifts 52944 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(52954..55308) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53037..53041 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53057..53076 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53060 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="upshifts" CDS 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" /label="ispE CDS" gene 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /label="ispE gene" CDS 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" /label="purR CDS" gene 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /label="purR gene" CDS 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" /label="ridA CDS" gene 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /label="ridA gene" downshifts 55253 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(55297..55315) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55298..55406 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55309) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(55331..55336) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55386..55394 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55405..55423 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55408 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="upshifts" CDS 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" /label="spoVG CDS" gene 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /label="spoVG gene" downshifts 55739 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" /label="downshifts" S_feature 55784..55895 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 55877..55881 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 55897..55916 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 55897 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" /label="glmU CDS" gene 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /label="glmU gene" downshifts complement(57288) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" CDS 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" /label="prs CDS" gene 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /label="prs gene" promotor_-35 58302..58308 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58321 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 58323..58341 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" /label="ctc CDS" gene 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /label="ctc gene" downshifts 58972 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" /label="pth CDS" gene 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /label="pth gene" misc_feature 59274..59277 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59280 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" /label="fin CDS" gene 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /label="fin gene" S_feature 59952..60020 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" /label="mfd CDS" gene 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /label="mfd gene" promotor_-35 63572..63578 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 63592..63689 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 63592..63603 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 63592 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" /label="spoVT CDS" gene 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /label="spoVT gene" downshifts 64230 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 64326..64345 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64337 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" /label="yabM CDS" gene 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /label="yabM gene" promotor_-35 65877..65884 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 65899..65918 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 65913 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="upshifts" CDS 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" /label="yabN CDS" gene 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /label="yabN gene" promotor_-35 66637..66644 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 66658..66676 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 66672 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="upshifts" promotor_no_box complement(67060..67160) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67100) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" /label="hslR CDS" gene 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /label="hslR gene" promotor_-35 67733..67738 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 67754..67772 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 67772 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(67804) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" /label="downshifts" CDS 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" /label="spcP CDS" gene 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /label="spcP gene" CDS 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" /label="spcQ CDS" gene 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /label="spcQ gene" promotor_-35 68611..68620 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68633..68648 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68635 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 68667..68675 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68686..68704 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68696 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" /label="divIC CDS" gene 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /label="divIC gene" CDS 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" /label="yabR CDS" gene 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /label="yabR gene" downshifts 69597 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 69711..69718 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69732..69751 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69747 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="upshifts" tRNA 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Met1 tRNA" gene 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /label="trnSL-Met1 gene" tRNA 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu1 tRNA" gene 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /label="trnSL-Glu1 gene" downshifts 69928 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 69973..70084 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70080..70099 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70086 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="upshifts" CDS 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" /label="spoIIE CDS" gene 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /label="spoIIE gene" downshifts 70170 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" /label="downshifts" S_feature complement(70781..71390) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(70807) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(71363..71381) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71389) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(71397..71402) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 71594..71600 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 71615..71633 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 71622 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 72632..72635 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72653..72670 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72656 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="upshifts" CDS 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" /label="yabS CDS" gene 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /label="yabS gene" CDS 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" /label="prkT CDS" gene 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /label="prkT gene" promotor_-35 73948..73954 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 73970..73988 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 73976 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="upshifts" promotor_-35 74446..74453 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74467..74486 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74477 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" /label="tilS CDS" gene 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /label="tilS gene" promotor_-35 75315..75322 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75337..75356 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75340 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" downshifts complement(75933) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" /label="hprT CDS" gene 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /label="hprT gene" upshifts complement(76340) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(76342..76346) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76364..76367) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76478..76574 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" /label="ftsH CDS" gene 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /label="ftsH gene" downshifts 78486 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(78525..78529) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78531..78616 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78533) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 78593..78600 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 78614..78633 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 78618..78682 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 78618 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" /label="coaX CDS" gene 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /label="coaX gene" CDS 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" /label="hslO CDS" gene 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /label="hslO gene" CDS 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" /label="yacD CDS" gene 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /label="yacD gene" promotor_-35 81016..81021 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81038..81056 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81039 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 81285..81292 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81307..81326 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81314 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" /label="cysK CDS" gene 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /label="cysK gene" downshifts 82281 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" /label="downshifts" promotor_-35 82335..82343 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82357..82365 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82359 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 82387..82390 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82405..82424 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82415 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" /label="pabB CDS" gene 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /label="pabB gene" promotor_-35 83257..83259 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83277..83295 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83283 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 83624..83631 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 83644..83663 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 83657 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" /label="pabA CDS" gene 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /label="pabA gene" CDS 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" /label="pabC CDS" gene 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /label="pabC gene" CDS 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" /label="folP CDS" gene 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /label="folP gene" CDS 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" /label="folB CDS" gene 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /label="folB gene" CDS 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" /label="folK CDS" gene 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /label="folK gene" CDS 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" /label="yazB CDS" gene 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /label="yazB gene" CDS 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " /label="dusB CDS" gene 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /label="dusB gene" S_feature complement(87641..89157) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88227..88317 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" /label="lysS CDS" gene 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /label="lysS gene" promotor_-10 complement(89141..89159) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89157) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(89175..89180) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 89798 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 89893..89900 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 89909..90126 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 89909 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 89914..89933 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(89959) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" rRNA 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-16S rRNA" gene 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /label="rrnJ-16S gene" rRNA 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-23S rRNA" gene 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /label="rrnJ-23S gene" rRNA 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-5S rRNA" gene 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /label="rrnJ-5S gene" tRNA 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Val tRNA" gene 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /label="trnJ-Val gene" tRNA 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Thr tRNA" gene 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /label="trnJ-Thr gene" tRNA 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Lys tRNA" gene 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /label="trnJ-Lys gene" tRNA 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu1 tRNA" gene 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /label="trnJ-Leu1 gene" tRNA 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Gly tRNA" gene 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /label="trnJ-Gly gene" tRNA 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu2 tRNA" gene 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /label="trnJ-Leu2 gene" tRNA 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Arg tRNA" gene 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /label="trnJ-Arg gene" tRNA 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Pro tRNA" gene 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /label="trnJ-Pro gene" tRNA 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Ala tRNA" gene 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /label="trnJ-Ala gene" rRNA 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-16S rRNA" gene 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /label="rrnW-16S gene" rRNA 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-23S rRNA" gene 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /label="rrnW-23S gene" rRNA 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-5S rRNA" gene 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /label="rrnW-5S gene" S_feature 100803..100880 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 100850..100853 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100869..100888 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100882 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-35 100916..100922 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 100936..100955 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 100947 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="upshifts" promotor_-35 100962..100969 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100983..101002 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100995 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" /label="ctsR CDS" gene 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /label="ctsR gene" misc_feature complement(101151..101155) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101157) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" /label="mcsA CDS" gene 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /label="mcsA gene" CDS 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" /label="mcsB CDS" gene 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /label="mcsB gene" CDS 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" /label="clpC CDS" gene 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /label="clpC gene" downshifts 105590 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" /label="radA CDS" gene 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /label="radA gene" promotor_-35 106142..106151 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106164..106179 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106167 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" /label="disA CDS" gene 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /label="disA gene" S_feature 108150..108264 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" /label="yacL CDS" gene 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /label="yacL gene" downshifts complement(109187) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" /label="downshifts" CDS 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" /label="ispD CDS" gene 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /label="ispD gene" CDS 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" /label="ispF CDS" gene 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /label="ispF gene" promotor_-35 110551..110558 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110572..110591 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110585 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" /label="gltX CDS" gene 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /label="gltX gene" promotor_-35 111567..111576 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111590..111609 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111590 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="upshifts" S_feature 112090..112390 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " /label="cysE CDS" gene 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /label="cysE gene" CDS 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" /label="cysS CDS" gene 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /label="cysS gene" CDS 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" /label="mrnC CDS" gene 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /label="mrnC gene" CDS 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" /label="rlmB CDS" gene 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /label="rlmB gene" CDS 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" /label="raeA CDS" gene 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /label="raeA gene" promotor_-35 116127..116134 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116149..116168 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116151 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" /label="sigH CDS" gene 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /label="sigH gene" downshifts complement(116645) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" /label="downshifts" S_feature 116848..116939 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" /label="rpmGB CDS" gene 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /label="rpmGB gene" CDS 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" /label="secE CDS" gene 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /label="secE gene" S_feature 117303..117480 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117474) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" /label="nusG CDS" gene 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /label="nusG gene" upshifts complement(117569) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(117572..117576) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(117591..117596) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118025..118032 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118043..118181 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118043 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 118046..118065 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" /label="rplK CDS" gene 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /label="rplK gene" S_feature 118608..118701 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" /label="rplA CDS" gene 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /label="rplA gene" downshifts complement(119374) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" /label="ldlJ RNA" gene 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /label="ldlJ gene" upshifts complement(119462) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(119465..119469) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119518 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" /label="downshifts" CDS 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" /label="rplJ CDS" gene 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /label="rplJ gene" CDS 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" /label="rplL CDS" gene 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /label="rplL gene" downshifts 120485 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" /label="downshifts" downshifts 120558 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" /label="downshifts" CDS 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" /label="rlmG CDS" gene 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /label="rlmG gene" promotor_-35 121259..121263 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121277..121509 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121277 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 121279..121298 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" /label="rpoB CDS" gene 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /label="rpoB gene" promotor_-10 complement(123095..123114) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123098) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123128..123137) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(123966..123970) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123971) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123985..123991) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" /label="rpoC CDS" gene 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /label="rpoC gene" downshifts complement(128217) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" upshifts complement(128371) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(128389..128390) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(128701) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 128753..128874 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 128856..128863 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 128876 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 128877..128896 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(128894..128898) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(128897) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" /label="rulS CDS" gene 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /label="rulS gene" S_feature 129180..129292 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" /label="rpsL CDS" gene 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /label="rpsL gene" CDS 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" /label="rpsG CDS" gene 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /label="rpsG gene" CDS 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" /label="fusA CDS" gene 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /label="fusA gene" S_feature 132354..132472 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" /label="tufA CDS" gene 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /label="tufA gene" downshifts 133658 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" /label="downshifts" misc_feature complement(133689..133692) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(133693) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 133719..133738 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 133727 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" /label="ybaC CDS" gene 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /label="ybaC gene" promotor_-35 134725..134732 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 134746..134765 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 134761..134954 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 134761 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" /label="rpsJ CDS" gene 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /label="rpsJ gene" CDS 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" /label="rplC CDS" gene 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /label="rplC gene" CDS 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" /label="rplD CDS" gene 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /label="rplD gene" CDS 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" /label="rplW CDS" gene 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /label="rplW gene" CDS 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" /label="rplB CDS" gene 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /label="rplB gene" downshifts complement(137038) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" CDS 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" /label="rpsS CDS" gene 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /label="rpsS gene" CDS 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" /label="rplV CDS" gene 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /label="rplV gene" CDS 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" /label="rpsC CDS" gene 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /label="rpsC gene" downshifts complement(138446) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(138527..138531) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138534) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(138548..138550) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" /label="rplP CDS" gene 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /label="rplP gene" CDS 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" /label="rpmC CDS" gene 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /label="rpmC gene" CDS 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" /label="rpsQ CDS" gene 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /label="rpsQ gene" CDS 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" /label="rplNA CDS" gene 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /label="rplNA gene" CDS 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" /label="rplX CDS" gene 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /label="rplX gene" CDS 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" /label="rplE CDS" gene 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /label="rplE gene" CDS 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" /label="rpsNA CDS" gene 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /label="rpsNA gene" CDS 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" /label="rpsH CDS" gene 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /label="rpsH gene" downshifts complement(141966) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" /label="downshifts" CDS 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" /label="rplF CDS" gene 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /label="rplF gene" CDS 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" /label="rplR CDS" gene 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /label="rplR gene" CDS 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" /label="rpsE CDS" gene 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /label="rpsE gene" CDS 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" /label="rpmD CDS" gene 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /label="rpmD gene" CDS 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" /label="rplO CDS" gene 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /label="rplO gene" CDS 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" /label="secY CDS" gene 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /label="secY gene" CDS 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " /label="adk CDS" gene 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /label="adk gene" CDS 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" /label="mapA CDS" gene 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /label="mapA gene" CDS 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" /label="ybzG CDS" gene 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /label="ybzG gene" CDS 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" /label="infA CDS" gene 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /label="infA gene" CDS 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" /label="rpmJ CDS" gene 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /label="rpmJ gene" CDS 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" /label="rpsM CDS" gene 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /label="rpsM gene" CDS 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" /label="rpsK CDS" gene 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /label="rpsK gene" S_feature 148346..148521 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" /label="rpoA CDS" gene 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /label="rpoA gene" CDS 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" /label="rplQ CDS" gene 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /label="rplQ gene" downshifts 149908 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" /label="downshifts" S_feature 149953..150033 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" /label="ecfA CDS" gene 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /label="ecfA gene" CDS 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" /label="ecfAB CDS" gene 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /label="ecfAB gene" CDS 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" /label="ecfT CDS" gene 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /label="ecfT gene" CDS 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" /label="truA CDS" gene 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /label="truA gene" S_feature complement(152630..153098) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 152763..152768 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 152783..152800 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 152802 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(153098..153117) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153120) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(153130..153139) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153291..153297 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153312..153331 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153316 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" /label="ldlM RNA" gene 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /label="ldlM gene" CDS 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" /label="rplM CDS" gene 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /label="rplM gene" CDS 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" /label="rpsI CDS" gene 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /label="rpsI gene" downshifts 154258 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" /label="downshifts" promotor_-35 154400..154407 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154421..154440 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154429..154710 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154429 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature 154709..154728 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 154712 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" /label="ybaJ CDS" gene 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /label="ybaJ gene" downshifts 155505 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 155644..155650 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 155665..155676 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 155672 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" /label="ybaK CDS" gene 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /label="ybaK gene" promotor_-35 156143..156148 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156164..156182 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156165 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" /label="cwlD CDS" gene 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /label="cwlD gene" upshifts 156961 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="upshifts" misc_feature 156964..156983 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" /label="salA CDS" gene 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /label="salA gene" S_feature complement(157641..158105) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158056 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" /label="downshifts" S_feature 158101..158772 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" /label="gerD CDS" gene complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /label="gerD gene" promotor_-10 complement(158695..158706) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(158707) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(158720..158726) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(158740..159369) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" /label="kbaA CDS" gene 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /label="kbaA gene" S_feature 159370..160264 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" /label="pdaB CDS" gene complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /label="pdaB gene" promotor_-10 complement(160165..160183) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160185) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(160199..160204) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160242..160249 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160264..160283 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160266..160483 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160266 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-16S rRNA" gene 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /modified_by="User" /label="rrnI-16S gene" Polymorphism join(160830,160832) /Source="geneious" /ID="SNP_BsDelta6_161240_161239" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=45 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value="4.2e-57" /Variant_Raw_Frequency=41 /comment="rrnI-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-23S rRNA" gene 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /label="rrnI-23S gene" rRNA 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-5S rRNA" gene 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /label="rrnI-5S gene" Polymorphism join(165341,165342) /Source="geneious" /ID="SNP_BsDelta6_165748_165749" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="-TC" /Codon_Change /Coverage="172 -> 174" /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TC" /Variant_Nucleotides /Variant_P_Value="1.5e-307" /Variant_Raw_Frequency=152 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(165342,165344) /Source="geneious" /ID="SNP_BsDelta6_165751_165751" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="C -> T" /Codon_Change /Coverage=172 /locus_tag /Protein_Effect /Reference_Frequency="1.2%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=168 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Asn tRNA" gene 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /label="trnI-Asn gene" Polymorphism join(165417,165419) /Source="geneious" /ID="SNP_BsDelta6_165826_165825" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=163 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=160 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Thr tRNA" gene 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /label="trnI-Thr gene" tRNA 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Gly tRNA" gene 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /label="trnI-Gly gene" Polymorphism join(165630,165632) /Source="geneious" /ID="SNP_BsDelta6_166038_166037" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="T" /Codon_Change /Coverage=154 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=148 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Arg tRNA" gene 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /label="trnI-Arg gene" tRNA 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Pro tRNA" gene 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /label="trnI-Pro gene" tRNA 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Ala tRNA" gene 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /label="trnI-Ala gene" Polymorphism join(165937,165938) /Source="geneious" /ID="SNP_BsDelta6_166344_166344" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-G" /Codon_Change /Coverage=132 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides /Variant_P_Value="4.9e-75" /Variant_Raw_Frequency=130 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-16S rRNA" gene 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /label="rrnH-16S gene" rRNA 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-23S rRNA" gene 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /label="rrnH-23S gene" rRNA 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-5S rRNA" gene 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /label="rrnH-5S gene" rRNA 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-16S rRNA" gene 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /label="rrnG-16S gene" rRNA 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-23S rRNA" gene 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /label="rrnG-23S gene" rRNA 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-5S rRNA" gene 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /label="rrnG-5S gene" S_feature 175915..176523 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176491..176495 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176511..176530 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176525..176681 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176525 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="upshifts" CDS 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" /label="ybaR CDS" gene 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /label="ybaR gene" downshifts 178107 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 178161..178166 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178179..178198 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178197 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="upshifts" CDS 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" /label="ybaS CDS" gene 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /label="ybaS gene" downshifts 179165 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" /label="eesA CDS" gene complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /label="eesA gene" downshifts complement(179218) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" /label="feuC CDS" gene complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /label="feuC gene" CDS complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" /label="feuB CDS" gene complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /label="feuB gene" CDS complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" /label="feuA CDS" gene complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /label="feuA gene" promotor_-35 182282..182288 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182303..182321 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182312 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(182953..182972) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(182960) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" /label="btr CDS" gene complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /label="btr gene" promotor_-10 complement(184643..184662) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(184655) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(184677..184684) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(184764) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" /label="ybbC CDS" gene complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /label="ybbC gene" downshifts complement(184814) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" /label="downshifts" CDS complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" /label="nagZ CDS" gene complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /label="nagZ gene" CDS complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" /label="amiE CDS" gene complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /label="amiE gene" CDS complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" /label="murP CDS" gene complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /label="murP gene" CDS complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" /label="murR CDS" gene complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /label="murR gene" CDS complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" /label="murQ CDS" gene complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /label="murQ gene" promotor_-10 complement(192595..192613) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(192608) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(192629..192636) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" /label="ybbJ CDS" gene complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /label="ybbJ gene" CDS complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" /label="ybbK CDS" gene complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /label="ybbK gene" promotor_-10 complement(193650..193669) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193671) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(193684..193685) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 193744..193751 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 193766..193785 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 193777 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" tRNA 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu2 tRNA" gene 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /label="trnSL-Glu2 gene" tRNA 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val1 tRNA" gene 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /label="trnSL-Val1 gene" tRNA 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Thr1 tRNA" gene 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /label="trnSL-Thr1 gene" tRNA 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Tyr1 tRNA" gene 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /label="trnSL-Tyr1 gene" tRNA 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gln2 tRNA" gene 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /label="trnSL-Gln2 gene" downshifts 194223 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 194268..194385 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194386..194395 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194387 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" promotor_-10 194407..194422 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" /label="sigW CDS" gene 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /label="sigW gene" CDS 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" /label="rsiW CDS" gene 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /label="rsiW gene" downshifts complement(195443) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(195601..195701) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 195631 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" upshifts complement(195641) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 195700..195707 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 195722..195741 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 195731..195811 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 195731 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="upshifts" CDS 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" /label="cdaA CDS" gene 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /label="cdaA gene" CDS 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" /label="cdaR CDS" gene 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /label="cdaR gene" CDS 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" /label="glmM CDS" gene 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /label="glmM gene" downshifts 199437 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 199461..199469 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199477 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 199483..199502 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199529..199534 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199550..199569 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199556 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_feature 199600..199616 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 199613 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" /label="glmSA RNA" gene 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /label="glmSA gene" S_feature 199787..199875 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" /label="glmS CDS" gene 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /label="glmS gene" S_feature complement(201401..>201681) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 201664 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" /label="downshifts" SCAR join(201681,201727) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 201682..201726 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <201727..201845 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" /label="ybdG CDS" gene 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /label="ybdG gene" CDS 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" /label="ybdJ CDS" gene 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /label="ybdJ gene" promotor_-35 203390..203396 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203410..203429 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203428 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" /label="ybdK CDS" gene 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /label="ybdK gene" promotor_-35 204491..204493 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204509..204528 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204512 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" /label="ybzI CDS" gene 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /label="ybzI gene" downshifts 204742 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" /label="ybdM CDS" gene complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /label="ybdM gene" CDS complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" /label="ybdN CDS" gene complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /label="ybdN gene" downshifts complement(205664) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(205713..205732) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(205746..205755) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(205748) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(206512..206531) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206537) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(206546..206553) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206567..206574 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206588..206606 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206590 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="upshifts" CDS 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" /label="ybdO CDS" gene 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /label="ybdO gene" downshifts 207801 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" promotor_-35 207969..207975 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 207989..208008 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208003..208132 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208003 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="upshifts" CDS 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" /label="ybxG CDS" gene 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /label="ybxG gene" downshifts 209529 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" promotor_-35 209567..209573 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209587..209598 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209588 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="upshifts" CDS 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" /label="csgA CDS" gene 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /label="csgA gene" CDS 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" /label="ybxH CDS" gene 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /label="ybxH gene" downshifts 210071 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" /label="ybxI CDS" gene complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /label="ybxI gene" promotor_-10 complement(210941..210959) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(210949) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(210970..210978) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211033..211039 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211054..211072 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211060 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="upshifts" CDS 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" /label="cypC CDS" gene 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /label="cypC gene" misc_feature 211404..211411 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211414 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 212338 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" /label="ybyB CDS" gene complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /label="ybyB gene" downshifts complement(212405) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(212676..212694) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(212685) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(212708..212714) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 212838..212845 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 212855 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 212861..212880 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" /label="ybeC CDS" gene 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /label="ybeC gene" downshifts 214517 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" /label="glpQA CDS" gene complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /label="glpQA gene" downshifts complement(214592) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(215505) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(215514..215530) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215539..215545) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" /label="glpT CDS" gene complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /label="glpT gene" promotor_-35 216543..216552 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216565..217191 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216565..216584 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216565 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216896..216968) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(216928..217028) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(216968) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216970..217056) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217046..217065) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217060) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(217078..217085) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" /label="ybeF CDS" gene 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /label="ybeF gene" promotor_-35 217464..217471 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217471 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 217487..217506 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" /label="ybfA CDS" gene 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /label="ybfA gene" CDS 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" /label="ybfB CDS" gene 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /label="ybfB gene" downshifts 219686 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" /label="ybfEc CDS" gene complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo /label="ybfEc gene" downshifts complement(219784) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" /label="ybfEn CDS" gene complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo /label="ybfEn gene" S_feature complement(220016..220136) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220121..220139) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220136) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(220138..220210) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220156..220161) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" /label="ybfF CDS" gene complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /label="ybfF gene" S_feature complement(221123..221210) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" /label="ybfG CDS" gene complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /label="ybfG gene" misc_feature complement(223444..223462) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223456) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" /label="ybfH CDS" gene complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /label="ybfH gene" CDS complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " /label="ybfI CDS" gene complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /label="ybfI gene" misc_feature complement(225255..225274) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225262) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 225402..225405 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225420..225439 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225425 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="upshifts" CDS 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" /label="purT CDS" gene 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /label="purT gene" downshifts 226594 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 226674..226679 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-35" upshifts 226688 /Source="Nicolas_upshifts" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="upshifts" promotor_-10 226694..226712 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-10" promotor_-35 226728..226735 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 226750..226769 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 226750 /Source="Nicolas_upshifts" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15205417, 15375126, 21819557, 25666135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular glutamyl-endopeptidase" /protein_id="NP_388106.1" /db_xref="EnsemblGenomes-Gn:BSU02240" /db_xref="EnsemblGenomes-Tr:CAB12018" /db_xref="GOA:P39790" /db_xref="InterPro:IPR000126" /db_xref="InterPro:IPR001254" /db_xref="InterPro:IPR008256" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR018114" /db_xref="InterPro:IPR028301" /db_xref="SubtiList:BG10690" /db_xref="UniProtKB/Swiss-Prot:P39790" /translation="MKLVPRFRKQWFAYLTVLCLALAAAVSFGVPAKAAENPQTSVSN TGKEADATKNQTSKADQVSAPYEGTGKTSKSLYGGQTELEKNIQTLQPSSIIGTDERT RISSTTSFPYRATVQLSIKYPNTSSTYGCTGFLVNPNTVVTAGHCVYSQDHGWASTIT AAPGRNGSSYPYGTYSGTMFYSVKGWTESKDTNYDYGAIKLNGSPGNTVGWYGYRTTN SSSPVGLSSSVTGFPCDKTFGTMWSDTKPIRSAETYKLTYTTDTYGCQSGSPVYRNYS DTGQTAIAIHTNGGSSYNLGTRVTNDVFNNIQYWANQ*" /label="mpr CDS" gene 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /label="mpr gene" CDS 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388107.1" /db_xref="EnsemblGenomes-Gn:BSU02250" /db_xref="EnsemblGenomes-Tr:CAB12019" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR019730" /db_xref="SubtiList:BG12739" /db_xref="UniProtKB/Swiss-Prot:O31451" /translation="MYSTIFNIGQINKYSKLAIFMSILFLCGCSSQTHSSQKETTIPV TLHVEDAKGLPVEGVQVTIVKAPSSDEEPSTEIGEILGKTDKNGDIKWDTGRKGDYSV ALTKGETSVTHHISLTEDKKDHAIPLVFKE*" /label="ybfJ CDS" gene 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /label="ybfJ gene" promotor_-10 complement(227753..227767) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(227763) /Source="Nicolas_upshifts" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(227783..227788) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 228046 /Source="Nicolas_upshifts" /id="D85" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.50775" /MaxDrop="5.06025" /score="29.4582027" /energy="-15.4" /TU="U156" /idTUdmin="U157" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 228115..228122 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 228137..228156 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 228150..228224 /Source="Nicolas_S_feature" /locus_tag="new_246583_246657" /HighExp="Cold, LoTm, S0, aero, ferm, T-4.40H, nit, T-5.40H, T-0.40H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S87" upshifts 228150 /Source="Nicolas_upshifts" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" CDS 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /translation="MIQDSMQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKT HIIASGPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAME TRADFAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFIS FHPDVYKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTEN GFPYVFTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLS LEQPEYVNQRVLSFLCGGIK*" /label="cesB CDS" gene 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /label="cesB gene" promotor_-35 228459..228466 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 228475 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 228480..228498 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 229116..229310 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" /label="pssA CDS" gene 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /label="pssA gene" CDS 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" /label="ybfM CDS" gene 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /label="ybfM gene" CDS 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" /label="psd CDS" gene 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /label="psd gene" downshifts 231082 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" /label="ybfN CDS" gene 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /label="ybfN gene" promotor_-35 231483..231492 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 231501 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 231505..231520 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" /label="ybfO CDS" gene 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /label="ybfO gene" downshifts 232886 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" upshifts 232952 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="upshifts" misc_feature 232955..232974 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" /label="ybfP CDS" gene 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /label="ybfP gene" S_feature 233882..234025 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 233997..234004 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 234018..234037 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 234027 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" /label="ybfQ CDS" gene 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /label="ybfQ gene" promotor_-10 complement(234903..234921) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234920) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234937..234942) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 235046 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" /label="downshifts" downshifts complement(235085) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" /label="gltP CDS" gene complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /label="gltP gene" promotor_-10 complement(236363..236381) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236372) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236392..236400) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(236400..236418) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236416) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236434..236439) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" /label="gamP CDS" gene complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /label="gamP gene" downshifts complement(236490) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" misc_feature 238235..238254 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 238252 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" /label="gamA CDS" gene complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /label="gamA gene" S_feature 239112..239293 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(239140..239210) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(239199..239218) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(239214) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(239234..239241) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 239280..239287 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 239295 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 239300..239319 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" /label="gamR CDS" gene 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /label="gamR gene" promotor_-35 240031..240032 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240048..240062 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240058 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="upshifts" CDS 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" /label="ybgB CDS" gene 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /label="ybgB gene" promotor_-10 complement(240157..240175) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(240163) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(240190..240196) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 240366 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 240417..240421 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240437..240456 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240443 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="upshifts" S_feature 240454..240582 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" /label="ilvE CDS" gene 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /label="ilvE gene" downshifts 241642 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" /label="ybgF CDS" gene complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /label="ybgF gene" downshifts complement(241707) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(243103..243214) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(243187..243206) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(243214) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(243221..243228) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" /label="ybgG CDS" gene complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /label="ybgG gene" promotor_-10 complement(244208..244227) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(244225) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="upshifts" promotor_-35 complement(244242..244249) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" /label="glnT CDS" gene complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /label="glnT gene" downshifts complement(244314) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" /label="downshifts" CDS complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" /label="glsA CDS" gene complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /label="glsA gene" promotor_-10 complement(246835..246852) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 246840..246859 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(246842) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 246846 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(246868..246875) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" /label="glnJ CDS" gene 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /label="glnJ gene" CDS 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" /label="glnL CDS" gene 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /label="glnL gene" downshifts 249207 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" promotor_-35 249327..249334 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 249339..249456 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 249339 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 249348..249367 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" /label="kdgD CDS" gene 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /label="kdgD gene" CDS 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" /label="gucD CDS" gene 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /label="gucD gene" CDS 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" /label="gudP CDS" gene 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /label="gudP gene" CDS 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" /label="gudD CDS" gene 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /label="gudD gene" promotor_-35 254748..254755 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 254770..254787 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 254773 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="upshifts" CDS 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" /label="garR CDS" gene 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /label="garR gene" downshifts 255455 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" downshifts 255499 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" /label="garD CDS" gene 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /label="garD gene" promotor_-35 257140..257143 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 257158..257177 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 257170..257404 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 257170 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" /label="ycbJ CDS" gene 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /label="ycbJ gene" promotor_-35 258327..258334 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 258349..258368 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 258359 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" /label="tboW RNA" gene 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /label="tboW gene" downshifts 258598 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" /label="rtpA CDS" gene 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /label="rtpA gene" promotor_no_box 258805..258905 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 258865 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" /label="ycbK CDS" gene 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /label="ycbK gene" downshifts 258953 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 259870..259889 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 259875..259943 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 259875 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="upshifts" CDS 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" /label="ycbL CDS" gene 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /label="ycbL gene" CDS 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" /label="ycbM CDS" gene 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /label="ycbM gene" CDS 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" /label="ycbN CDS" gene 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /label="ycbN gene" S_feature complement(262123..263307) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" /label="ycbO CDS" gene 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /label="ycbO gene" CDS complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" /label="hypothetical protein CDS" gene complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /label="gene" downshifts 263276 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" CDS complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" /label="ycbP CDS" gene complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /label="ycbP gene" downshifts complement(263352) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(263748..263766) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(263767) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(263780..263786) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(263800..264798) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(263843) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" /label="downshifts" promotor_-35 263979..263984 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 263998 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 264000..264018 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264012) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(264014..264028) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(264034) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 complement(264036..264040) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" /label="cwlJ CDS" gene 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /label="cwlJ gene" downshifts 264443 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 264509..264515 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 264528..264547 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 264530 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="upshifts" CDS 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" /label="ycbR CDS" gene 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /label="ycbR gene" promotor_-10 complement(264772..264791) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264798) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(264805..264812) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 265219 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" /label="yczK CDS" gene 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /label="yczK gene" promotor_-35 265511..265517 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 265524..265541 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 265535 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="upshifts" CDS 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" /label="phoD CDS" gene 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /label="phoD gene" promotor_-10 complement(265632..265647) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(265638) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(265660..265669) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" /label="tatAD CDS" gene 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /label="tatAD gene" S_feature 267555..267614 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" /label="tatCD CDS" gene 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /label="tatCD gene" downshifts complement(267623) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" /label="pcp CDS" gene complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /label="pcp gene" promotor_-10 complement(269002..269021) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 269015..269021 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(269016) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(269036..269040) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 269036..269055 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 269038 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="upshifts" CDS 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" /label="ycbU CDS" gene 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /label="ycbU gene" upshifts complement(269412) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(269415..269434) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(269450..269454) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 270172 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" /label="lmrB CDS" gene complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /label="lmrB gene" downshifts complement(270227) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" /label="lmrA CDS" gene complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /label="lmrA gene" promotor_-10 complement(272303..272322) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(272317) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(272337..272344) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 272419..272425 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272441..272458 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272447 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="upshifts" CDS 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" /label="ansZ CDS" gene 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /label="ansZ gene" downshifts 273582 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 273706..273712 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 273726..273745 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 273726 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" /label="estA CDS" gene 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /label="estA gene" downshifts 274396 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" /label="downshifts" S_feature 274441..275031 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" /label="yczC CDS" gene complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /label="yczC gene" downshifts complement(274472) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" Polymorphism join(274645,274647) /Source="geneious" /ID="SNP_BsDelta6_293079_293079" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=186 /Change="C -> T" /Codon_Change="CTG -> CTA" /Coverage=154 /locus_tag="BSU_02710" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" promotor_-10 complement(274861..274880) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(274868) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(274894..274901) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 275003..275006 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 275022..275041 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 275033 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" /label="yccF CDS" gene 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /label="yccF gene" downshifts 276136 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" /label="natK CDS" gene complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /label="natK gene" downshifts complement(276210) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" /label="natR CDS" gene complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /label="natR gene" promotor_-10 complement(277876..277895) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(277882) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(277911..277914) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 277932..277935 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 277951..277970 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 277961 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" /label="natA CDS" gene 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /label="natA gene" CDS 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" /label="natB CDS" gene 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /label="natB gene" promotor_-35 279948..279956 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 279968..279986 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 279968 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" /label="yccK CDS" gene 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /label="yccK gene" CDS complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" /label="ycdA CDS" gene complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /label="ycdA gene" downshifts complement(281006) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(282070..282260) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " /label="hypothetical protein CDS" gene complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /label="gene" promotor_-10 complement(282245..282264) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282265) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(282279..282286) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" /label="ycdB CDS" gene 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /label="ycdB gene" promotor_-10 complement(283858..283876) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(283866) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(283890..283897) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 283922..284001 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 283922 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="upshifts" promotor_-35 283924..283930 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 283945..283962 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" /label="ycdC CDS" gene 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /label="ycdC gene" S_feature 285364..285944 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" /label="cwlK CDS" gene complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /label="cwlK gene" S_feature complement(285875..285956) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 285946 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="upshifts" promotor_-10 complement(285948..285967) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 285949..285968 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(285957) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="upshifts" CDS 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" /label="rapJ CDS" gene 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /label="rapJ gene" downshifts 287112 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 287159..287165 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 287180..287198 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 287183 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" /label="ycdF CDS" gene 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /label="ycdF gene" downshifts complement(287232) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" /label="downshifts" CDS 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" /label="ycdG CDS" gene 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /label="ycdG gene" promotor_no_box 288966..289066 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 289026 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 289092 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" /label="downshifts" downshifts 289708 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" promotor_-35 289802..289809 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 289825..289844 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 289831 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" /label="znuA CDS" gene 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /label="znuA gene" promotor_-35 290454..290460 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290474..290493 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290478 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" downshifts 290830 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" /label="znuC CDS" gene 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /label="znuC gene" CDS 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" /label="znuB CDS" gene 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /label="znuB gene" downshifts 292396 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" /label="yceB CDS" gene complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /label="yceB gene" promotor_-35 293398..293405 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 293420..293439 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 293426..293628 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 293426 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="upshifts" promotor_-10 complement(293474..293493) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(293482) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(293508..293515) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 293612..293621 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 293630..293725 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 293630 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 293634..293649 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" /label="yceC CDS" gene 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /label="yceC gene" CDS 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" /label="yceD CDS" gene 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /label="yceD gene" CDS 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" /label="yceE CDS" gene 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /label="yceE gene" CDS 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" /label="yceF CDS" gene 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /label="yceF gene" downshifts 296352 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" /label="downshifts" CDS 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" /label="yceG CDS" gene 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /label="yceG gene" CDS 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" /label="yceH CDS" gene 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /label="yceH gene" downshifts 299144 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" /label="downshifts" promotor_-35 299224..299231 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 299246..299265 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 299254 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="upshifts" CDS 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" /label="niaP CDS" gene 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /label="niaP gene" downshifts 300474 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" /label="yceJ CDS" gene complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /label="yceJ gene" downshifts complement(300762) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" /label="yceK CDS" gene complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /label="yceK gene" downshifts complement(302016) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(302273..302292) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(302292) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(302306..302312) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 302539..302558 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 302539 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="upshifts" CDS 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" /label="opuAA CDS" gene 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /label="opuAA gene" downshifts complement(302588) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" /label="downshifts" CDS 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" /label="opuAB CDS" gene 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /label="opuAB gene" CDS 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" /label="opuAC CDS" gene 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /label="opuAC gene" downshifts 305548 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(305580) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" /label="amhX CDS" gene complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /label="amhX gene" downshifts complement(305624) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" S_feature complement(306757..306844) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 306812..306819 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(306831..306850) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 306834..306853 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(306844) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="upshifts" upshifts 306847 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="upshifts" promotor_-35 complement(306863..306869) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" /label="ycgA CDS" gene 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /label="ycgA gene" promotor_-35 307644..307652 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 307664..307682 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 307683 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 308321 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 308382..308389 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308404..308423 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308413 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" /label="ycgB CDS" gene 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /label="ycgB gene" upshifts 308849 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" misc_feature 308853..308857 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 309012..309019 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 309034..309053 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 309047..309184 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 309047 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" /label="amyE CDS" gene 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /label="amyE gene" downshifts 311178 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 311244..311251 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 311261 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 311265..311284 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" /label="lctE CDS" gene 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /label="lctE gene" CDS 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" /label="lctP CDS" gene 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /label="lctP gene" downshifts 312344 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" /label="downshifts" downshifts 313950 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" /label="mdr CDS" gene complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /label="mdr gene" downshifts complement(314026) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(314600..314700) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(314640) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 315560..315564 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315580..315599 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315594 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(315626..315645) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(315629) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="upshifts" CDS 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" /label="ycgE CDS" gene 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /label="ycgE gene" promotor_-35 complement(315660..315666) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 316133..316138 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316154..316172 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316164 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" /label="ycgF CDS" gene 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /label="ycgF gene" promotor_-35 316837..316846 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316860..316879 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316868 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" /label="ycgG CDS" gene 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /label="ycgG gene" S_feature complement(317296..317658) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 317654 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" /label="ycgH CDS" gene complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /label="ycgH gene" promotor_-10 complement(319026..319037) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319036) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(319052..319058) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 319078..319084 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319092 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 319099..319110 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" /label="ycgI CDS" gene 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /label="ycgI gene" promotor_-35 319733..319740 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 319754..319854 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 319754..319773 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 319754 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(319850) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" /label="nadE CDS" gene 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /label="nadE gene" downshifts 320655 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" /label="downshifts" CDS complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" /label="tmrB CDS" gene complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /label="tmrB gene" downshifts complement(320730) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(321331..321350) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(321346) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(321365..321368) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(321374..321522) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 321424..321431 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 321444..321463 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 321446..321554 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 321448 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(321516..321534) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321522..321529 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321532) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 321544..321563 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321550..321555) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321556 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="upshifts" CDS 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" /label="aroK CDS" gene 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /label="aroK gene" downshifts 322129 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" /label="ycgJ CDS" gene complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /label="ycgJ gene" downshifts complement(322204) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(322973..322992) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 322974..322981 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(322979) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 322996..323015 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(323007..323012) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 323008 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" CDS 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" /label="ycgK CDS" gene 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /label="ycgK gene" S_feature 324034..324104 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" /label="cah CDS" gene 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /label="cah gene" promotor_-35 324520..324526 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324541..324552 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324548 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" S_feature 325062..325140 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 325115..325120 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 325137..325155 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 325142 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" CDS 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" /label="ycgL CDS" gene 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /label="ycgL gene" downshifts 325892 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 325937..326064 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 326041..326045 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326060..326079 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326066 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" /label="putB CDS" gene 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /label="putB gene" CDS 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" /label="putC CDS" gene 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /label="putC gene" promotor_-35 328017..328023 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328037..328056 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328045 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 328128..328134 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328147..328166 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328156 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" misc_feature 328592..328596 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 328594..328716 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 328596 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" /label="putP CDS" gene 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /label="putP gene" S_feature complement(329237..331092) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 330118 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" /label="downshifts" S_feature 330163..330259 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 330230..330237 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 330252..330271 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 330261 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" /label="putR CDS" gene 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /label="putR gene" promotor_-10 complement(331085..331103) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(331102) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(331117..331124) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(331510) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" /label="ycgQ CDS" gene complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /label="ycgQ gene" downshifts complement(331576) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" /label="ycgR CDS" gene complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /label="ycgR gene" upshifts complement(333361) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(333366..333379) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(333394..333402) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" /label="ycgS CDS" gene complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /label="ycgS gene" promotor_-10 complement(334282..334301) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(334302) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="upshifts" promotor_-35 complement(334316..334319) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 334353..334372 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(334353..334371) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 334360..334424 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 334361 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(334370) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(334387..334392) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" /label="ffoR CDS" gene 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /label="ffoR gene" S_feature 335436..337883 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" /label="nasF CDS" gene complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /label="nasF gene" downshifts complement(335471) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" /label="nasE CDS" gene complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /label="nasE gene" promotor_-35 337150..337155 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 337169..337173 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 337176 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(337208) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(337210..337229) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(337243..337250) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" /label="nasD CDS" gene complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /label="nasD gene" promotor_-10 complement(339773..339792) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(339787) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(339804..339810) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" /label="nasC CDS" gene complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /label="nasC gene" CDS complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" /label="nasB CDS" gene complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /label="nasB gene" promotor_no_box complement(344343..344443) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(344383) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 344426..344433 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 344447..344466 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 344459 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="upshifts" CDS 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" /label="nasA CDS" gene 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /label="nasA gene" downshifts 345694 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 345753..345759 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 345774..345793 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 345782 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="upshifts" CDS 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" /label="folEB CDS" gene 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /label="folEB gene" CDS 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" /label="yciB CDS" gene 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /label="yciB gene" promotor_-35 347332..347339 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 347353..347372 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 347363 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="upshifts" CDS 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" /label="yczL CDS" gene 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /label="yczL gene" CDS 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" /label="zinU CDS" gene 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /label="zinU gene" downshifts 348815 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" S_feature 348860..350529 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" /label="yckA CDS" gene complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /label="yckA gene" downshifts complement(348878) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" /label="yckB CDS" gene complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /label="yckB gene" promotor_-10 complement(350447..350466) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(350459) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(350461..353295) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(350481..350488) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 350498..350504 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350519..350537 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 350531..350753 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 350531 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" /label="hypothetical protein CDS" gene 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /label="gene" promotor_-35 350722..350727 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350743..350761 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 350755 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" /label="yckC CDS" gene 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /label="yckC gene" downshifts 351233 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 351281..351287 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 351294 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 351301..351312 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" /label="yckD CDS" gene 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /label="yckD gene" downshifts 351653 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 351758..351765 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 351781..351800 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 351785 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="upshifts" CDS 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" /label="bglC CDS" gene 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /label="bglC gene" downshifts 353237 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" /label="nin CDS" gene complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /label="nin gene" promotor_no_box complement(353691..353791) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" /label="nucA CDS" gene complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /label="nucA gene" upshifts complement(353731) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(354185..354204) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(354193) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(354195..354337) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(354218..354225) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" /label="tlpC CDS" gene complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /label="tlpC gene" promotor_-35 354350..354357 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 354368..357511 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 354368 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 354372..354391 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(354373..354473) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(354413) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="upshifts" promotor_-10 complement(356083..356101) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(356098) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="upshifts" promotor_-35 complement(356115..356122) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" /label="hxlB CDS" gene complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /label="hxlB gene" downshifts complement(356173) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" /label="hxlA CDS" gene complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /label="hxlA gene" promotor_-10 complement(357391..357410) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(357406) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(357425..357428) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 357489..357492 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 357507..357526 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 357513 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="upshifts" CDS 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" /label="hxlR CDS" gene 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /label="hxlR gene" downshifts 357945 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 358208..358211 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 358226..358245 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 358234..358534 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 358234 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="upshifts" CDS 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" /label="srfAA CDS" gene 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /label="srfAA gene" CDS 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" /label="srfAB CDS" gene 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /label="srfAB gene" CDS 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" CDS 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" /label="srfAC CDS" gene 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /label="srfAC gene" CDS 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" /label="srfAD CDS" gene 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /label="srfAD gene" downshifts 384665 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" /label="downshifts" promotor_-35 384721..384728 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 384731 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 384740..384759 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" /label="srfT CDS" gene 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /label="srfT gene" downshifts 386004 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" /label="ycxB CDS" gene complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /label="ycxB gene" promotor_no_box complement(386040..386140) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(386062) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" /label="downshifts" upshifts complement(386080) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(386611..386630) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(386613) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" /label="ycxC CDS" gene complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /label="ycxC gene" promotor_-10 complement(387613..387631) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(387620) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(387647..387652) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" /label="ycxD CDS" gene 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /label="ycxD gene" CDS complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" /label="sfpAc CDS" gene complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo /label="sfpAc gene" CDS complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" /label="sfpAn CDS" gene complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo /label="sfpAn gene" misc_feature complement(389729..389748) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(389741) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" CDS complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" /label="yczE CDS" gene complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /label="yczE gene" promotor_-10 complement(390483..390502) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(390486) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(390518..390522) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(390623..390774) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" /label="tcyC CDS" gene complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /label="tcyC gene" downshifts complement(390831) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" /label="tcyB CDS" gene complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /label="tcyB gene" CDS complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" /label="tcyA CDS" gene complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /label="tcyA gene" promotor_-10 complement(393078..393097) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393090) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393111..393118) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" /label="bsdA CDS" gene complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /label="bsdA gene" promotor_-10 complement(393755..393773) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393762) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393788..393794) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 394071..394078 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(394086..394105) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 394092..394111 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(394092) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="upshifts" upshifts 394100 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="upshifts" CDS 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" /label="ubiX CDS" gene 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /label="ubiX gene" promotor_-35 complement(394119..394126) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" /label="bsdC CDS" gene 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /label="bsdC gene" CDS 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" /label="bsdD CDS" gene 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /label="bsdD gene" CDS 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" /label="yclD CDS" gene 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /label="yclD gene" downshifts 396831 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 396857..396858 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 396858 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" /label="yclE CDS" gene 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /label="yclE gene" CDS complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" /label="dtpT CDS" gene complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /label="dtpT gene" downshifts complement(397810) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 399307..399309 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399308..399327) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399318 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 399326..399344 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399328) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(399330..>399513) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(399342..399349) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 399498..399507 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 399513..399514 /note_="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_011" downshifts 399519 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(399529..400968) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" /label="gabR CDS" gene complement(399529..400968) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /label="gabR gene" promotor_-10 complement(399853..399864) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399859) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(399878..399884) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(401011..401030) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 401012..401019 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(401018) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 401033..401052 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 401037 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(401041..401048) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 401075..402385 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" /label="gabT CDS" gene 401075..402385 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /label="gabT gene" promotor_-35 402263..402269 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 402283..402301 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 402291 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 402387..402394 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 402409..402428 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 402418 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" CDS 402454..403842 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" /label="gabD CDS" gene 402454..403842 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /label="gabD gene" downshifts 403850 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 403900..403906 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 403920..403931 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 403921 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="upshifts" CDS 403965..404828 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" /label="glcU CDS" gene 403965..404828 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /label="glcU gene" CDS 404848..405633 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" /label="gdh CDS" gene 404848..405633 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /label="gdh gene" misc_feature 404953..404972 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 404953 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 405041 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" /label="downshifts" downshifts 405635 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" /label="downshifts" CDS complement(405678..406292) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" /label="cutI CDS" gene complement(405678..406292) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /label="cutI gene" downshifts complement(405689) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(406305..407930) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" /label="cutJ CDS" gene complement(406305..407930) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /label="cutJ gene" CDS complement(407965..408537) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" /label="cutR CDS" gene complement(407965..408537) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /label="cutR gene" promotor_-10 complement(408559..408578) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(408574) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(408592..408599) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 408659..408678 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 408671 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="upshifts" CDS 408702..409055 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" /label="ycnL CDS" gene 408702..409055 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /label="ycnL gene" downshifts 409026 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 409119..409126 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 409140..409159 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 409145 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" S_feature 409155..409227 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 409228..410664 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" /label="mtlA CDS" gene 409228..410664 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /label="mtlA gene" CDS 410689..411120 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" /label="mtlF CDS" gene 410689..411120 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /label="mtlF gene" CDS 411122..412243 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" /label="mtlD CDS" gene 411122..412243 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /label="mtlD gene" downshifts 412226 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-35 412272..412275 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 412291..412310 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 412293 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="upshifts" CDS 412334..413398 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" /label="ycsA CDS" gene 412334..413398 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /label="ycsA gene" promotor_-35 412568..412576 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 412590..412609 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 412600 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 413392 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 413465..413472 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413485..413504 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413498 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 413533..414096 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" /label="sipU CDS" gene 413533..414096 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /label="sipU gene" S_feature 414097..414821 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(414156..414764) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" /label="yczH CDS" gene complement(414156..414764) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /label="yczH gene" misc_feature complement(414782..414801) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 414798..414804 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(414805) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 414817..414836 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 414823 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 414850..415242 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" /label="ycsD CDS" gene 414850..415242 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /label="ycsD gene" downshifts 415219 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(415275..415439) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" /label="yczO CDS" gene complement(415275..415439) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /label="yczO gene" downshifts complement(415295) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(415449..415467) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(415471) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(415482..415488) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 415501..415508 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 415522..415541 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 415525 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="upshifts" CDS 415572..416321 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" /label="ribZ CDS" gene 415572..416321 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /label="ribZ gene" downshifts 416298 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(416374) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" promotor_-35 416404..416410 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 416424..416443 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 416430..416526 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 416430 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 416527..417300 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" /label="pxpA CDS" gene 416527..417300 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /label="pxpA gene" CDS 417315..418529 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" /label="pxpG CDS" gene 417315..418529 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /label="pxpG gene" CDS 418553..419326 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" /label="pxpI CDS" gene 418553..419326 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /label="pxpI gene" CDS 419371..420093 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" /label="pxpB CDS" gene 419371..420093 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /label="pxpB gene" CDS 420096..421103 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" /label="pxpC CDS" gene 420096..421103 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /label="pxpC gene" downshifts 420589 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" /label="downshifts" promotor_no_box 420683..420783 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 420743 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 421119..421871 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" /label="pxpR CDS" gene 421119..421871 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /label="pxpR gene" promotor_-35 421869..421878 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421892..421911 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421902 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 421935..422576 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" /label="lipC CDS" gene 421935..422576 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /label="lipC gene" downshifts 422562 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(422574..422999) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(422619) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 422652..422658 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 422672..422691 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 422673 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="upshifts" CDS 422749..422994 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" /label="yczI CDS" gene 422749..422994 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /label="yczI gene" S_feature 422995..423405 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(423000..423287) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" /label="yczJ CDS" gene complement(423000..423287) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /label="yczJ gene" misc_feature complement(423308..423327) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(423324) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 423381..423385 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 423402..423421 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 423407 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 423438..425444 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" /label="pbpC CDS" gene 423438..425444 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /label="pbpC gene" S_feature 425445..425545 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 425546..426448 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" /label="ycsN CDS" gene 425546..426448 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /label="ycsN gene" downshifts 426428 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 426521..426528 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 426542..426561 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 426546..426633 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 426546 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 426634..428718 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" /label="mtlR CDS" gene 426634..428718 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /label="mtlR gene" downshifts 428705 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 428747..428753 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 428767..428785 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 428779 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="upshifts" S_feature 428790..428871 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 428833..428840 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 428854..428873 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 428873 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="upshifts" CDS 428930..430441 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" /label="ydaB CDS" gene 428930..430441 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /label="ydaB gene" downshifts 430425 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" /label="downshifts" CDS complement(430461..431006) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" /label="ydaC CDS" gene complement(430461..431006) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /label="ydaC gene" downshifts complement(430494) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(431073..431091) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(431087) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(431106..431112) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 431148..431154 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 431166 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="upshifts" promotor_-10 431169..431187 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 431213..432073 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" /label="ydaD CDS" gene 431213..432073 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /label="ydaD gene" CDS 432089..432592 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" /label="lyxE CDS" gene 432089..432592 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /label="lyxE gene" downshifts 432573 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" /label="downshifts" promotor_-35 432621..432628 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 432642..432661 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 432644 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 432678..433229 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" /label="ydaF CDS" gene 432678..433229 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /label="ydaF gene" promotor_-35 433244..433250 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 433265..433283 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 433278 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 433307..433729 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" /label="ydaG CDS" gene 433307..433729 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /label="ydaG gene" promotor_-35 433734..433742 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 433753..433772 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 433772..434138 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 433772 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(433798..433898) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(433833..434101) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" /label="bsrC RNA" gene complement(433833..434101) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /label="bsrC gene" upshifts complement(433838) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 434095 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 434175..434184 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 434197..434212 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 434202 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 434235..435044 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" /label="amj CDS" gene 434235..435044 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /label="amj gene" downshifts 435025 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" /label="downshifts" CDS complement(435088..435378) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" /label="ydzA CDS" gene complement(435088..435378) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /label="ydzA gene" downshifts complement(435092) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(435406..435425) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 435406..435424 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 435412 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(435422) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 435500..435507 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 435521..435540 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 435525 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 435563..435997 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" /label="lrpC CDS" gene 435563..435997 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /label="lrpC gene" promotor_-35 435994..435997 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 436006 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 436014..436033 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 436062..438245 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" /label="topB CDS" gene 436062..438245 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /label="topB gene" downshifts 438228 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 438294..438300 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 438315..438333 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 438316..438447 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 438316 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="upshifts" CDS 438448..439536 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" /label="epsJ CDS" gene 438448..439536 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /label="epsJ gene" CDS 439517..440368 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" /label="epsK CDS" gene 439517..440368 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /label="epsK gene" CDS 440379..442088 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" /label="ydaL CDS" gene 440379..442088 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /label="ydaL gene" CDS 442081..443343 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" /label="ydaM CDS" gene 442081..443343 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /label="ydaM gene" CDS 443349..445460 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" /label="ydaN CDS" gene 443349..445460 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /label="ydaN gene" downshifts 445444 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" /label="downshifts" promotor_-35 445557..445564 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 445579..445598 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 445586 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 445596..445739 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" /label="swaO RNA" gene 445596..445739 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /label="swaO gene" downshifts 445737 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" /label="downshifts" S_feature 445782..445935 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 445936..447759 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" /label="kimA CDS" gene 445936..447759 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /label="kimA gene" downshifts 447751 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" /label="downshifts" CDS 447818..448267 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" /label="nudT CDS" gene 447818..448267 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /label="nudT gene" promotor_-35 448280..448286 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 448301..448319 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 448302 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="upshifts" CDS 448334..450058 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" /label="poxB CDS" gene 448334..450058 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /label="poxB gene" S_feature complement(449170..450029) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(450031..450142) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 450042 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(450050..450253) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" /label="hypothetical protein CDS" gene complement(450050..450253) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /label="gene" downshifts complement(450074) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(450102..450202) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 450111..450116 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450133..450151 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(450142) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature 450143..450358 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 450143 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(450209..450280) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(450252) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(450281..450547) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" /label="ydzK CDS" gene complement(450281..450547) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /label="ydzK gene" promotor_-10 complement(450563..450582) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(450581) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(450594..450601) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(450651..451928) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" /label="mntH CDS" gene complement(450651..451928) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /label="mntH gene" downshifts complement(450670) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(451990..452009) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(452002) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(452004..452081) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(452022..452029) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(452065..452084) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(452081) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(452098..452107) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(452158..452415) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" /label="ydaS CDS" gene complement(452158..452415) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /label="ydaS gene" downshifts complement(452166) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" downshifts complement(452232) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS complement(452493..452945) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" /label="ydaT CDS" gene complement(452493..452945) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /label="ydaT gene" promotor_-10 complement(452964..452982) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(452981) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(452996..453002) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 453014 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 453022..453041 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 453063..453881 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" /label="ydbA CDS" gene 453063..453881 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /label="ydbA gene" downshifts 453872 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 453949..453955 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 453969..453987 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 453977 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="upshifts" CDS 454010..454381 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" /label="gsiB CDS" gene 454010..454381 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /label="gsiB gene" downshifts complement(454014) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 454398 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" upshifts complement(454432) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(454435..454438) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 454460..454467 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 454479..454498 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 454486 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="upshifts" CDS 454513..454854 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" /label="ydbB CDS" gene 454513..454854 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /label="ydbB gene" CDS 454848..455207 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" /label="ydbC CDS" gene 454848..455207 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /label="ydbC gene" S_feature complement(454910..455203) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 455148 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 455192 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(455244..456065) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" /label="ydbD CDS" gene complement(455244..456065) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /label="ydbD gene" downshifts complement(455248) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(456087..456105) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(456108) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(456119..456125) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(456150..457202) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" /label="dctB CDS" gene complement(456150..457202) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /label="dctB gene" promotor_-35 456462..456469 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 456484..457271 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 456484..456503 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 456485 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(457215..457234) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(457220) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(457248..457255) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 457272..458879 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" /label="dctS CDS" gene 457272..458879 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /label="dctS gene" CDS 458869..459549 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" /label="dctR CDS" gene 458869..459549 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /label="dctR gene" S_feature 459550..459624 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 459591..459598 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 459613..459630 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 459626 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="upshifts" CDS 459670..460935 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" /label="dctP CDS" gene 459670..460935 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /label="dctP gene" downshifts 460928 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(460982) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" /label="downshifts" misc_feature 461019..461036 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 461021 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 461083..462135 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" /label="ydbI CDS" gene 461083..462135 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /label="ydbI gene" S_feature 462136..462379 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 462336 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" CDS 462412..463338 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" /label="ydbJ CDS" gene 462412..463338 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /label="ydbJ gene" CDS 463358..464098 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" /label="ydbK CDS" gene 463358..464098 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /label="ydbK gene" misc_feature 464157..464176 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 464162 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 464193..464528 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" /label="ydbL CDS" gene 464193..464528 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /label="ydbL gene" downshifts 464503 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" /label="downshifts" S_feature 464548..464617 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 464583..464590 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 464604..464623 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 464618 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 464656..465801 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" /label="ydbM CDS" gene 464656..465801 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /label="ydbM gene" downshifts 465783 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(465826..466005) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" /label="fbpB CDS" gene complement(465826..466005) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /label="fbpB gene" downshifts complement(465844) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(465959..466123) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" /label="fbpA CDS" gene complement(465959..466123) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /label="fbpA gene" S_feature complement(466006..466174) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(466166..466185) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(466176) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(466200..466207) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 466315..466320 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 466336..466354 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 466340 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="upshifts" CDS 466370..467242 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" /label="ydbO CDS" gene 466370..467242 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /label="ydbO gene" promotor_-35 466606..466615 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 466628..466643 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 466631 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(467187..467256) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(467230) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 467243..467592 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(467257..467577) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" /label="ydbP CDS" gene complement(467257..467577) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /label="ydbP gene" promotor_-35 467573..467577 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 467586..467600 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 467594..467751 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 467594 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(467598..467617) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(467613) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(467631..467638) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 467752..468816 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" /label="ddlA CDS" gene 467752..468816 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /label="ddlA gene" downshifts 468804 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS 468888..470261 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" /label="murF CDS" gene 468888..470261 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /label="murF gene" promotor_-35 470292..470298 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 470312..470323 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 470322 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 470365..470384 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 470366..470540 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 470366 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 470508..470515 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 470530..470549 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 470542..470609 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 470542 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="upshifts" CDS 470661..472145 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" /label="cshA CDS" gene 470661..472145 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /label="cshA gene" downshifts 472138 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" S_feature 472258..472317 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 472258..472267 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 472260 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 472279..472294 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 472318..472797 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " /label="ydbS CDS" gene 472318..472797 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /label="ydbS gene" CDS 472787..474268 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" /label="ydbT CDS" gene 472787..474268 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /label="ydbT gene" downshifts 474238 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature 474283..474610 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(474292) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" /label="downshifts" CDS complement(474520..475119) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" /label="ydcA CDS" gene complement(474520..475119) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /label="ydcA gene" promotor_-35 474580..474585 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 474598..474617 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 474612..475213 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 474612 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(475143..475162) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(475154) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="upshifts" CDS 475214..475579 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" /label="acpS CDS" gene 475214..475579 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /label="acpS gene" promotor_-35 475582..475587 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 475603..475744 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 475603..475621 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 475603 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="upshifts" CDS 475745..476761 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" /label="ydcC CDS" gene 475745..476761 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /label="ydcC gene" downshifts 476746 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 476806..476813 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476827..476846 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476834 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 476876..478045 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" /label="alrA CDS" gene 476876..478045 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /label="alrA gene" promotor_-35 477974..477979 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 477994..478012 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478000 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 478075..478078 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 478094..478113 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478095 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 478161..478442 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" /label="ndoAI CDS" gene 478161..478442 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /label="ndoAI gene" CDS 478447..478797 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" /label="ndoA CDS" gene 478447..478797 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /label="ndoA gene" S_feature complement(478587..479063) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(478630) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts 478777 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" /label="downshifts" promotor_-35 478831..478838 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 478852..478871 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478860 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 478912..479736 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" /label="rsbRA CDS" gene 478912..479736 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /label="rsbRA gene" promotor_-10 complement(479046..479064) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(479063) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(479065..479664) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(479078..479085) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(479653..479671) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(479664) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(479666..480254) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(479685..479691) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 479741..480106 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" /label="rsbS CDS" gene 479741..480106 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /label="rsbS gene" CDS 480110..480511 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" /label="rsbT CDS" gene 480110..480511 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /label="rsbT gene" promotor_-10 complement(480252..480271) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(480269) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(480285..480294) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 480523..481530 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" /label="rsbU CDS" gene 480523..481530 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /label="rsbU gene" promotor_-35 481524..481530 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 481545..481563 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 481551 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 481592..481921 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" /label="rsbV CDS" gene 481592..481921 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /label="rsbV gene" CDS 481918..482400 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" /label="rsbW CDS" gene 481918..482400 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /label="rsbW gene" CDS 482366..483154 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" /label="sigB CDS" gene 482366..483154 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /label="sigB gene" CDS 483154..483753 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" /label="rsbX CDS" gene 483154..483753 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /label="rsbX gene" downshifts 483739 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 483797..483803 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 483818..483837 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" Polymorphism join(483826,483828) /Source="geneious" /ID="SNP_BsDelta6_524323_524323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="A -> C" /Codon_Change /Coverage=183 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="BSU_04745_promoter_down_mutation" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 483830 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 483864..483980 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" /label="hypothetical protein CDS" gene 483864..483980 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /label="gene" CDS 483996..484289 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" /label="ydcF CDS" gene 483996..484289 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /label="ydcF gene" promotor_-35 484257..484265 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 484277..484296 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 484286..484726 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" /label="ydcG CDS" gene 484286..484726 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /label="ydcG gene" upshifts 484292 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(484525..487580) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 484710..485153 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" /label="ydcH CDS" gene 484710..485153 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /label="ydcH gene" downshifts 485128 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 485184..485185 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 485201..485220 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 485201 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="upshifts" CDS 485247..487406 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" /label="tex CDS" gene 485247..487406 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /label="tex gene" misc_feature 487394..487413 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 487416..487632 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 487416 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="upshifts" CDS complement(487416..487529) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" /label="cmpA CDS" gene complement(487416..487529) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /label="cmpA gene" promotor_-10 complement(487569..487588) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(487586) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(487603..487611) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 487633..488085 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" /label="ydcK CDS" gene 487633..488085 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /label="ydcK gene" promotor_-35 488091..488097 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488112..488131 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 488120..488207 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 488120 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(488152) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" /label="downshifts" tRNA 488208..488282 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Asn tRNA" gene 488208..488282 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /label="trnS-Asn gene" tRNA 488287..488377 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Ser tRNA" gene 488287..488377 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /label="trnS-Ser gene" tRNA 488407..488478 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Glu tRNA" gene 488407..488478 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /label="trnS-Glu gene" tRNA 488490..488564 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Gln tRNA" gene 488490..488564 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /label="trnS-Gln gene" tRNA 488591..488666 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Lys tRNA" gene 488591..488666 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /label="trnS-Lys gene" tRNA 488678..488759 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu1 tRNA" gene 488678..488759 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /label="trnS-Leu1 gene" downshifts 488824 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA 488840..>488925 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu2 tRNA" gene 488840..>488925 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /modified_by="User" /label="trnS-Leu2 gene" SCAR 488925..488926 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="Delta6_2" S_feature complement(<488926..489232) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S175" downshifts 488945 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" /label="downshifts" downshifts complement(488977) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(489233..490252) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" /label="yddN CDS" gene complement(489233..490252) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /label="yddN gene" promotor_-10 complement(489928..489947) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(489941) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(489962..489969) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 490041..490045 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 490062..490081 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 490066 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="upshifts" S_feature 490067..490511 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 490512..490922 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" /label="lrpA CDS" gene 490512..490922 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /label="lrpA gene" S_feature 490923..490992 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 490949 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" /label="downshifts" CDS complement(491045..491494) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" /label="lrpB CDS" gene complement(491045..491494) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /label="lrpB gene" CDS 491609..492151 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" /label="yddQ CDS" gene 491609..492151 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /label="yddQ gene" promotor_-35 492624..492628 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492645..492664 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 492654 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="upshifts" CDS 492704..493468 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" /label="yddR CDS" gene 492704..493468 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /label="yddR gene" CDS 493662..494972 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" /label="yddS CDS" gene 493662..494972 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /label="yddS gene" S_feature 494995..495554 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 495555..495731 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" /label="ydzM CDS" gene 495555..495731 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /label="ydzM gene" CDS 495756..496442 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" /label="yddT CDS" gene 495756..496442 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /label="yddT gene" promotor_-35 496784..496788 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 496803..496822 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 496811 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="upshifts" Polymorphism join(496858,496860) /Source="geneious" /ID="SNP_BsDelta6_557866_557865" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)5 -> (T)6" /Codon_Change /Coverage=35 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value="3.2e-123" /Variant_Raw_Frequency=35 /comment="ydzN_translation_signal_variant" /modified_by="User" / /label="Polymorphism_Delta6" CDS 496867..497052 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" /label="ydzN CDS" gene 496867..497052 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /label="ydzN gene" downshifts 497051 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" /label="downshifts" CDS 497402..497995 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" /label="sufLC CDS" gene 497402..497995 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /label="sufLC gene" promotor_-35 498108..498115 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 498129..498148 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 498140..498257 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 498140 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(498175) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" /label="downshifts" CDS 498258..498458 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" /label="cspC CDS" gene 498258..498458 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /label="cspC gene" S_feature complement(498356..499144) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 498361 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 498462 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" /label="downshifts" misc_RNA complement(498526..498604) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sncZ RNA" gene complement(498526..498604) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /label="sncZ gene" CDS complement(499145..499606) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" /label="cdnL CDS" gene complement(499145..499606) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /label="cdnL gene" S_feature 499615..500160 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(499658) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(499665..499684) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(499700..499707) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 500127 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" /label="downshifts" CDS complement(500174..500410) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" /label="ydzE CDS" gene complement(500174..500410) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /label="ydzE gene" CDS complement(500508..501383) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" /label="ydeC CDS" gene complement(500508..501383) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /label="ydeC gene" CDS 501496..502455 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" /label="ydeD CDS" gene 501496..502455 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /label="ydeD gene" upshifts complement(501517) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(501521..501540) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(502608..503480) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" /label="ydeE CDS" gene complement(502608..503480) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /label="ydeE gene" promotor_-10 complement(503573..503578) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(503580..503581) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(503585) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 503654..503660 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 503668 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 503674..503693 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 503707..505095 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" /label="ydeF CDS" gene 503707..505095 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /label="ydeF gene" downshifts 505071 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS 505205..506497 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" /label="ydeG CDS" gene 505205..506497 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /label="ydeG gene" promotor_-35 506506..506512 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506527..506546 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 506534 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="upshifts" S_feature 506545..506655 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 506656..507102 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" /label="ydeH CDS" gene 506656..507102 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /label="ydeH gene" downshifts 507131 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 507182..507189 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 507204..507223 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 507205 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="upshifts" CDS 507339..507932 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" /label="ydeI CDS" gene 507339..507932 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /label="ydeI gene" downshifts 507975 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(508051) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 508064..508071 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 508085 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 508086..508105 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(508284..508943) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" /label="ydeJ CDS" gene complement(508284..508943) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /label="ydeJ gene" promotor_-10 complement(508992..509011) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(508999) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(509023..509028) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(509365..510228) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" /label="ydeK CDS" gene complement(509365..510228) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /label="ydeK gene" promotor_-35 510271..510277 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 510292..510311 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(510293..510312) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 510307 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(510317) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(510327..510334) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 510383..511774 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" /label="ydeL CDS" gene 510383..511774 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /label="ydeL gene" promotor_-35 511902..511909 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 511920..511939 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 511934 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="upshifts" CDS 511968..512393 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" /label="ydeM CDS" gene 511968..512393 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /label="ydeM gene" S_feature 512394..513648 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(512446..513018) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" /label="ydeN CDS" gene complement(512446..513018) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /label="ydeN gene" downshifts complement(512451) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(513019..513099) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(513100..513429) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" /label="ydzF CDS" gene complement(513100..513429) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /label="ydzF gene" misc_feature complement(513446..513465) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(513463) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="upshifts" misc_feature 513637..513656 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 513650 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="upshifts" CDS 513684..514556 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" /label="ydeO CDS" gene 513684..514556 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /label="ydeO gene" downshifts 514443 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 514641 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(514706..515092) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" /label="ydeP CDS" gene complement(514706..515092) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /label="ydeP gene" downshifts complement(514718) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(515093..515157) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 515145..515152 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(515146..515165) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(515159) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 515166..515185 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 515169 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(515180..515187) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 515203..515796 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" /label="ydeQ CDS" gene 515203..515796 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /label="ydeQ gene" CDS complement(515940..517127) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" /label="ydeR CDS" gene complement(515940..517127) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /label="ydeR gene" promotor_-35 517263..517267 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 517281 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 517282..517301 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 517331..517927 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" /label="ydeS CDS" gene 517331..517927 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /label="ydeS gene" CDS 518041..518226 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" /label="ydzO CDS" gene 518041..518226 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /label="ydzO gene" downshifts 518205 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 518338..518341 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 518348..518534 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 518348 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 518356..518375 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 518535..518870 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" /label="aseR CDS" gene 518535..518870 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /label="aseR gene" CDS 518883..520190 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" /label="arsF CDS" gene 518883..520190 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /label="arsF gene" CDS 520222..520326 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" /label="ydzSn CDS" gene 520222..520326 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo /label="ydzSn gene" CDS 520335..520448 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" /label="ydzSc CDS" gene 520335..520448 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo /label="ydzSc gene" promotor_-35 520634..520642 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 520653..520671 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 520670 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 520688..521473 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" /label="ydfB CDS" gene 520688..521473 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /label="ydfB gene" downshifts 520735 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 521483 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS complement(521530..522450) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" /label="ydfC CDS" gene complement(521530..522450) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /label="ydfC gene" CDS 522583..524031 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" /label="ydfD CDS" gene 522583..524031 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /label="ydfD gene" CDS complement(524149..524772) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" /label="ydfE CDS" gene complement(524149..524772) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /label="ydfE gene" promotor_-10 complement(524796..524815) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 524804..524811 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(524815) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 524826..524845 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 524828 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(524830..524836) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 524862..525542 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" /label="ydfF CDS" gene 524862..525542 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /label="ydfF gene" downshifts 525575 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(525622..526065) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" /label="ydfG CDS" gene complement(525622..526065) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /label="ydfG gene" downshifts complement(525627) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(526088..526107) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(526112) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(526121..526128) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(526151..526330) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" /label="ydzP CDS" gene complement(526151..526330) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /label="ydzP gene" CDS complement(526327..526470) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" /label="ydzQ CDS" gene complement(526327..526470) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /label="ydzQ gene" promotor_-35 526421..526423 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 526439..526458 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 526455 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 526738..527961 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" /label="ydfH CDS" gene 526738..527961 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /label="ydfH gene" CDS 527954..528595 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" /label="ydfI CDS" gene 527954..528595 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /label="ydfI gene" downshifts 528589 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(528622..528641) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(528643) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(528655..528662) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 528703..528708 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 528711..530885 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" /label="ydfJ CDS" gene 528711..530885 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /label="ydfJ gene" upshifts 528721 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 528723..528741 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(529787..529805) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(529787) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(530889..531296) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 530906..530910 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 530920 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 530923..530942 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(530934) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(531297..532199) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" /label="cesA CDS" gene complement(531297..532199) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /label="cesA gene" S_feature complement(532200..532295) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(532275..532294) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(532295) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(532308..532315) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(532401..533090) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" /label="ydfK CDS" gene complement(532401..533090) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /label="ydfK gene" CDS complement(533180..533992) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" /label="ydfL CDS" gene complement(533180..533992) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /label="ydfL gene" promotor_-10 complement(534021..534040) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(534034) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(534056..534063) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(534103..534996) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" /label="mneP CDS" gene complement(534103..534996) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /label="mneP gene" downshifts complement(534123) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(534997..535089) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(535070..535089) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(535087) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(535105..535112) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 535278..535285 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 535300..535319 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 535306 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 535472..536092 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" /label="ydfN CDS" gene 535472..536092 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /label="ydfN gene" promotor_-35 535816..535822 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 535827 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 535836..535854 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 536108..537046 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" /label="ydfO CDS" gene 536108..537046 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /label="ydfO gene" promotor_-35 537034..537037 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 537052..537071 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 537059..537147 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 537059 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 537148..537537 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" /label="ydfP CDS" gene 537148..537537 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /label="ydfP gene" downshifts 537528 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" /label="downshifts" misc_feature 537651..537670 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 537653..537722 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 537653 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 537723..538061 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" /label="ydfQ CDS" gene 537723..538061 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /label="ydfQ gene" downshifts 538049 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(538101..538337) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" /label="ydzH CDS" gene complement(538101..538337) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /label="ydzH gene" downshifts complement(538125) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 538149..538155 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 538170..538181 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 538181 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(538338..538499) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(538503..538868) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(538543) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(538869..539099) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" /label="ydzR CDS" gene complement(538869..539099) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /label="ydzR gene" downshifts 539083 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(539120..539139) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(539137) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(539139..539222) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(539153..539162) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(539223..539900) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" /label="ydfR CDS" gene complement(539223..539900) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /label="ydfR gene" promotor_-10 complement(539871..539882) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(539885) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(539897..539903) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(539901..540734) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 539916..539921 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 539936..539947 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 539941 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="upshifts" CDS 540013..540720 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" /label="ydfS CDS" gene 540013..540720 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /label="ydfS gene" CDS complement(540735..541166) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" /label="cotP CDS" gene complement(540735..541166) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /label="cotP gene" CDS complement(541179..541421) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" /label="ydgA CDS" gene complement(541179..541421) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /label="ydgA gene" CDS complement(541435..541707) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" /label="ydgB CDS" gene complement(541435..541707) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /label="ydgB gene" promotor_-10 complement(541729..541748) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(541733) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(541762..541771) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 541926..541933 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 541949..541968 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 541957 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="upshifts" CDS 542006..542593 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" /label="ydgC CDS" gene 542006..542593 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /label="ydgC gene" CDS 542590..542934 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" /label="ydgD CDS" gene 542590..542934 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /label="ydgD gene" S_feature 542935..543096 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 543097..543570 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" /label="ydgE CDS" gene 543097..543570 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /label="ydgE gene" S_feature 543571..544263 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(543713) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(543730..545373) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" /label="vmlR CDS" gene complement(543730..545373) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /label="vmlR gene" S_feature complement(545408..545605) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 545422..545424 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 545441..545459 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 545445 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(545451) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 545571 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(545597..545616) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(545609) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(545629..545636) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(545692) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(545693..547069) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" /label="ydgF CDS" gene complement(545693..547069) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /label="ydgF gene" misc_feature complement(547119..547138) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(547134) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="upshifts" Polymorphism join(547208,547210) /Source="geneious" /ID="SNP_BsDelta6_608215_608214" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)5 -> (A)6" /Codon_Change /Coverage=41 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="8.2e-115" /Variant_Raw_Frequency=39 /comment="dinB_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" terminator 547209..547242 /created_by="User" /comment="dinB_terminator_improvement" /modified_by="User" /label="Delta6_dinB_Terminator" CDS complement(547241..547759) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" /label="dinB CDS" gene complement(547241..547759) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /label="dinB gene" downshifts complement(547255) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(547785..547804) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(547804) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(547820..547823) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 547841..547848 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 547863..547882 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 547881 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="upshifts" CDS complement(547893..548294) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /locus_tag="BSU_05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /modified_by="User" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_BSU_05890_3'_ext" CDS complement(547893..548021) /locus_tag="PG10_rand_002" /created_by="User" /transl_table=11 /pseudo /translation="MYNHGNLITDLLDNLLLESTGVLQKTRIYEMSSNQTHYSLPR*" /label="PG10_rand_002" gene complement(547893..548294) /gene="ydhUc" /locus_tag="PG10_BSU_05890_3'_ext" /old_locus_tag="BSU_05890" /pseudo /modified_by="User" /label="PG10_BSU_05890_3'_ext" gene complement(547893..548021) /locus_tag="PG10_rand_002" /created_by="User" /label="PG10_rand_002" CDS 547911..548003 /locus_tag="PG10_rand_001" /created_by="User" /transl_table=11 /pseudo /translation="MRLIRAHFINSCFLQHTCRLKKQVIQQVSN*" /label="PG10_rand_001" gene 547911..548003 /locus_tag="PG10_rand_001" /created_by="User" /modified_by="User" /label="PG10_rand_001" SCAR 547913..547914 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs22" CDS complement(548225..548419) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" /label="ydhUn CDS" gene complement(548225..548419) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo /label="ydhUn gene" promotor_-10 complement(548452..548463) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(548460) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(548477..548483) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 548538..548545 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 548559..548578 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 548561..548661 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 548563 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(548609) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" upshifts 548621 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 548629..548636 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 548650..548669 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 548665..548752 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 548665 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" tRNA 548753..548829 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Arg tRNA" gene 548753..548829 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /label="trnE-Arg gene" tRNA 548843..548916 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Gly tRNA" gene 548843..548916 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /label="trnE-Gly gene" rRNA 549076..550630 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-16S rRNA" gene 549076..550630 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /label="rrnE-16S gene" rRNA 550798..553725 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-23S rRNA" gene 550798..553725 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /label="rrnE-23S gene" rRNA 553781..553897 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-5S rRNA" gene 553781..553897 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /label="rrnE-5S gene" tRNA 553911..553987 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Met tRNA" gene 553911..553987 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /label="trnE-Met gene" tRNA 554048..554124 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Asp tRNA" gene 554048..554124 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /label="trnE-Asp gene" downshifts 554121 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" /label="downshifts" promotor_-35 554225..554229 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 554245..554264 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 554249 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="upshifts" CDS 554305..555282 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" /label="thiL CDS" gene 554305..555282 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /label="thiL gene" CDS 555297..555773 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" /label="tsaE CDS" gene 555297..555773 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /label="tsaE gene" CDS 555754..556443 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" /label="tsaB CDS" gene 555754..556443 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /label="tsaB gene" CDS 556453..556908 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" /label="rimI CDS" gene 556453..556908 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /label="rimI gene" CDS 556901..557941 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" /label="tsaD CDS" gene 556901..557941 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /label="tsaD gene" downshifts 557905 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(558171..560099) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" /label="ydiF CDS" gene complement(558171..560099) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /label="ydiF gene" downshifts complement(558188) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" misc_feature 559851..559870 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 559861 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" S_feature 559863..560052 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 560017..560024 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 560038..560057 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 560054..560224 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 560054 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(560119..560138) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(560131) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(560152..560159) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 560225..560737 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" /label="moaC CDS" gene 560225..560737 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /label="moaC gene" CDS 560734..561381 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" /label="rex CDS" gene 560734..561381 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /label="rex gene" promotor_no_box 561211..561311 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 561271 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" CDS 561403..561576 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" /label="tatAY CDS" gene 561403..561576 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /label="tatAY gene" CDS 561583..562347 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" /label="tatCY CDS" gene 561583..562347 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /label="tatCY gene" downshifts 562327 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(562385..562576) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" /label="ydiK CDS" gene complement(562385..562576) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /label="ydiK gene" downshifts complement(562402) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(562573..563307) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" /label="ydiL CDS" gene complement(562573..563307) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /label="ydiL gene" promotor_-35 562965..562970 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 562985..563003 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 562987 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 563306..563307 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 563317..563331 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 563339 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="upshifts" promotor_-10 complement(563344..563363) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 563361..563469 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(563364) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(563377..563382) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 563443..563449 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 563463..563482 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 563471..563545 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 563471 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="upshifts" CDS 563546..563830 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" /label="groES CDS" gene 563546..563830 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /label="groES gene" CDS 563877..565511 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" /label="groEL CDS" gene 563877..565511 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /label="groEL gene" S_feature 565512..565604 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 565561 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" /label="downshifts" CDS complement(565599..565727) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" /label="ydzTc CDS" gene complement(565599..565727) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo /label="ydzTc gene" S_feature 565606..>566832 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(565730..565888) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" /label="ydzT CDS" gene complement(565730..565888) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo /label="ydzT gene" CDS complement(565933..566061) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" /label="ydzT CDS" gene complement(565933..566061) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo /label="ydzT gene" CDS complement(566154..566363) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" /label="ydzT CDS" gene complement(566154..566363) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo /label="ydzT gene" CDS complement(566356..566661) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " /label="ydzTn CDS" gene complement(566356..566661) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo /label="ydzTn gene" SCAR join(566832,566839) /created_by="AR/SM" /note="deletion occured in betwen marked nucleotides" /label="Delta6_1" N_region 566833..566838 /note="KpnI site (GGTACC)" /created_by="User" /label="Delta6_1" CDS complement(566937..569426) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" /label="gutR CDS" gene complement(566937..569426) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /label="gutR gene" downshifts complement(566959) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(569440..569459) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(569466) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(569473..569480) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 569529..569530 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 569545..569627 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 569545 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 569546..569565 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 569628..570689 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" /label="gutB CDS" gene 569628..570689 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /label="gutB gene" CDS 570763..572154 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" /label="gutP CDS" gene 570763..572154 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /label="gutP gene" promotor_-35 572181..572188 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 572202..572221 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 572207 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="upshifts" CDS 572249..573211 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" /label="ydjE CDS" gene 572249..573211 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /label="ydjE gene" downshifts 573196 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 573336..573345 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 573352 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 573358..573373 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 573407..574090 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" /label="pspA CDS" gene 573407..574090 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /label="pspA gene" S_feature 574091..574155 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 574156..575181 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" /label="ydjG CDS" gene 574156..575181 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /label="ydjG gene" CDS 575181..575945 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" /label="ydjH CDS" gene 575181..575945 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /label="ydjH gene" CDS 575976..576947 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" /label="ydjI CDS" gene 575976..576947 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /label="ydjI gene" downshifts 576937 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 576981 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(576994..578019) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" /label="ydjJ CDS" gene complement(576994..578019) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /label="ydjJ gene" promotor_-10 complement(578051..578070) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(578069) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(578084..578090) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 578279..578286 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 578299 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="upshifts" S_feature 578301..578603 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 578301..578320 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 578604..580025 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" /label="iolT CDS" gene 578604..580025 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /label="iolT gene" downshifts 580017 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(580073) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(580073..581113) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" /label="bdhA CDS" gene complement(580073..581113) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /label="bdhA gene" promotor_-35 580653..580662 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 580676..580695 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 580677..581212 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 580677 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(581114..581408) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 581213..581232 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 581214..581511 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 581214 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="upshifts" misc_feature complement(581403..581417) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(581408) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 581510..581529 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 581513 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="upshifts" CDS 581552..581923 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" /label="walM CDS" gene 581552..581923 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /label="walM gene" downshifts 581909 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS 581989..583035 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" /label="ydjN CDS" gene 581989..583035 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /label="ydjN gene" downshifts 583009 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(583069..583227) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" /label="ydzJ CDS" gene complement(583069..583227) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /label="ydzJ gene" downshifts complement(583085) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(583284..583416) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(583327) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(583417..583626) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" /label="ydjO CDS" gene complement(583417..583626) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /label="ydjO gene" promotor_-10 complement(583659..583678) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(583670) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" CDS complement(583709..584524) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" /label="ydjP CDS" gene complement(583709..584524) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /label="ydjP gene" promotor_-35 584351..584360 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 584373..584392 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 584373 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(584537..585526) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" /label="yeaA CDS" gene complement(584537..585526) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /label="yeaA gene" promotor_-10 complement(585391..585409) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(585399) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(585425..585430) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(585548..585563) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(585569) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(585575..585584) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(585624..587165) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" /label="cotA CDS" gene complement(585624..587165) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /label="cotA gene" downshifts complement(585637) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(587196..587215) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(587210) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="upshifts" promotor_-35 complement(587229..587238) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(587317..588726) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" /label="gabP CDS" gene complement(587317..588726) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /label="gabP gene" downshifts complement(587331) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(588764..589051) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" /label="ydzX CDS" gene complement(588764..589051) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /label="ydzX gene" misc_feature complement(588767..588786) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(588781) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="upshifts" promotor_-35 589057..589064 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 589080..589099 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 589081 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="upshifts" CDS 589124..589996 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" /label="mneS CDS" gene 589124..589996 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /label="mneS gene" downshifts 589961 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(590236) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" /label="downshifts" misc_feature 590290..590309 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 590300 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="upshifts" CDS 590346..591308 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" /label="yeaC CDS" gene 590346..591308 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /label="yeaC gene" CDS 591308..592504 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" /label="yeaD CDS" gene 591308..592504 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /label="yeaD gene" CDS 592526..594739 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" /label="yebA CDS" gene 592526..594739 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /label="yebA gene" promotor_-35 594734..594741 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 594756..594775 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 594772..594901 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 594772 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="upshifts" CDS 594902..596443 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" /label="guaA CDS" gene 594902..596443 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /label="guaA gene" downshifts 596429 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 596550..596554 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 596570..596589 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 596580 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="upshifts" misc_RNA 596587..596689 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswC RNA" gene 596587..596689 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /label="gswC gene" downshifts 596715 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 596824..598146 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" /label="pbuG CDS" gene 596824..598146 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /label="pbuG gene" downshifts 598124 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 598167 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" /label="downshifts" promotor_-35 598196..598205 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 598216..598356 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 598216 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 598218..598233 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 598357..599160 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" /label="yebC CDS" gene 598357..599160 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /label="yebC gene" downshifts 599145 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 599228..599235 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 599249..599268 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 599255..599318 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 599255 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="upshifts" CDS 599319..599486 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" /label="yebD CDS" gene 599319..599486 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /label="yebD gene" downshifts 599493 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 599537..599543 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 599558..599576 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 599561..599647 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 599561 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 599626..599633 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 599647..599666 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 599649 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="upshifts" CDS 599700..600254 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" /label="yebE CDS" gene 599700..600254 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /label="yebE gene" CDS 600254..600451 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" /label="yebG CDS" gene 600254..600451 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /label="yebG gene" downshifts 600441 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 600497..600504 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 600519..600538 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 600521 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 600531..600633 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswD RNA" gene 600531..600633 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /label="gswD gene" S_feature 600634..600773 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 600774..601262 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" /label="purE CDS" gene 600774..601262 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /label="purE gene" CDS 601255..602397 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" /label="purK CDS" gene 601255..602397 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /label="purK gene" CDS 602394..603689 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" /label="purB CDS" gene 602394..603689 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /label="purB gene" promotor_-10 complement(602699..602718) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(602720) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(602733..602740) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 603763..604488 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" /label="purC CDS" gene 603763..604488 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /label="purC gene" CDS 604481..604735 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" /label="purS CDS" gene 604481..604735 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /label="purS gene" CDS 604732..605415 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" /label="purQ CDS" gene 604732..605415 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /label="purQ gene" CDS 605399..607627 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" /label="purL CDS" gene 605399..607627 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /label="purL gene" downshifts complement(605647) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" /label="downshifts" CDS 607603..609033 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" /label="purF CDS" gene 607603..609033 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /label="purF gene" S_feature 609034..609134 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 609135..610175 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" /label="purM CDS" gene 609135..610175 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /label="purM gene" CDS 610172..610759 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" /label="purN CDS" gene 610172..610759 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /label="purN gene" misc_feature 610182..610196 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 610191 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(610458..610476) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(610465) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(610492..610497) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 610756..612294 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" /label="purH CDS" gene 610756..612294 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /label="purH gene" CDS 612310..613578 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" /label="purD CDS" gene 612310..613578 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /label="purD gene" downshifts 613563 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(613618..614037) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" /label="yezC CDS" gene complement(613618..614037) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /label="yezC gene" misc_feature complement(614107..614126) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(614116) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="upshifts" CDS 614181..615455 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" /label="yecA CDS" gene 614181..615455 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /label="yecA gene" downshifts 615404 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" /label="downshifts" CDS complement(615470..615697) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" /label="yezF CDS" gene complement(615470..615697) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /label="yezF gene" downshifts complement(615481) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(615698..616118) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 615765..615770 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 615781 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 615784..615803 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 615826..617568 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" /label="yerA CDS" gene 615826..617568 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /label="yerA gene" promotor_-10 complement(616103..616114) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(616118) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(616128..616134) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 616149 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" /label="downshifts" promotor_-35 617542..617548 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 617560 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 617561..617580 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 617595..618590 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" /label="yerB CDS" gene 617595..618590 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /label="yerB gene" CDS 618593..618907 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" /label="yerC CDS" gene 618593..618907 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /label="yerC gene" downshifts 618770 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" downshifts 618912 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" /label="downshifts" CDS complement(618942..620519) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" /label="yerD CDS" gene complement(618942..620519) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /label="yerD gene" downshifts complement(618956) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(620533..620552) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(620552) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(620567..620573) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 620716..620719 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 620733 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 620736..620755 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 620784..621470 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" /label="pcrB CDS" gene 620784..621470 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /label="pcrB gene" CDS 621532..623751 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " /label="pcrA CDS" gene 621532..623751 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /label="pcrA gene" CDS 623775..625781 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" /label="ligA CDS" gene 623775..625781 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /label="ligA gene" CDS 625797..626987 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" /label="yerH CDS" gene 625797..626987 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /label="yerH gene" misc_feature complement(625992..625996) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(625996) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 627024..627043 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 627032..627148 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 627032 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(627096) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" CDS 627149..628159 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" /label="yerI CDS" gene 627149..628159 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /label="yerI gene" promotor_no_box complement(627166..627266) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(627206) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 628142 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 628186..628990 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(628197..628895) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" /label="sapB CDS" gene complement(628197..628895) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /label="sapB gene" downshifts complement(628218) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(628915..628933) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(628936) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(628949..628954) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(629002..630480) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" /label="opuE CDS" gene complement(629002..630480) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /label="opuE gene" downshifts complement(629016) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" /label="downshifts" upshifts complement(629868) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(629871..629884) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(630481..630611) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(630602..630620) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(630611) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(630635..630641) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 630742..630745 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 630760..630893 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 630760 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 630762..630781 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 630894..631184 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" /label="gatC CDS" gene 630894..631184 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /label="gatC gene" CDS 631200..632657 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" /label="gatA CDS" gene 631200..632657 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /label="gatA gene" CDS 632671..634101 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" /label="gatB CDS" gene 632671..634101 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /label="gatB gene" downshifts 634082 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(634116..634985) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" /label="yerO CDS" gene complement(634116..634985) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /label="yerO gene" downshifts complement(634158) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 634775..634780 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 634796..634814 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 634808 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="upshifts" S_feature complement(634986..635060) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 635038..635045 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(635054..635073) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 635060 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 635061..635080 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(635067) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(635088..635095) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 635117..638275 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" /label="srfP CDS" gene 635117..638275 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /label="srfP gene" downshifts 638262 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 638514..638517 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 638532..638551 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 638540 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="upshifts" CDS 638598..639509 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" /label="dagK CDS" gene 638598..639509 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /label="dagK gene" S_feature 639510..639764 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 639765..641144 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" /label="rlmCD CDS" gene 639765..641144 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /label="rlmCD gene" S_feature 641145..641737 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(641157..642059) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" /label="yefB CDS" gene complement(641157..642059) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /label="yefB gene" downshifts 641694 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 641739..642039 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 642040..642375 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" /label="yefC CDS" gene 642040..642375 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /label="yefC gene" S_feature 642376..642449 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 642450..645089 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" /label="yeeA CDS" gene 642450..645089 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /label="yeeA gene" CDS 645101..646900 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" /label="yeeB CDS" gene 645101..646900 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /label="yeeB gene" promotor_-10 complement(645341..645356) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(645356) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(645368..645377) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 646901..647012 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 647013..648161 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" /label="yeeC CDS" gene 647013..648161 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /label="yeeC gene" S_feature 648162..649351 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(648423..648728) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " /label="yeeD CDS" gene complement(648423..648728) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /label="yeeD gene" CDS complement(648795..649001) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" /label="yezA CDS" gene complement(648795..649001) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /label="yezA gene" CDS complement(649241..649696) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" /label="yezG CDS" gene complement(649241..649696) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /label="yezG gene" downshifts complement(649254) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" /label="downshifts" CDS complement(649716..651725) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" /label="yeeF CDS" gene complement(649716..651725) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /label="yeeF gene" promotor_-10 complement(650083..650102) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(650090) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(650115..650120) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(651752..651771) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(651762) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="upshifts" CDS 651937..652959 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" /label="yeeG CDS" gene 651937..652959 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /label="yeeG gene" promotor_-35 653059..653066 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 653080..653099 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 653081 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="upshifts" CDS 653121..654251 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" /label="rapH CDS" gene 653121..654251 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /label="rapH gene" CDS 654241..654414 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" /label="phrH CDS" gene 654241..654414 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /label="phrH gene" downshifts 654369 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" /label="downshifts" S_feature 654415..654519 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 654486..654493 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 654508..654527 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 654521 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="upshifts" CDS 654574..655293 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" /label="yeeI CDS" gene 654574..655293 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /label="yeeI gene" downshifts complement(654576) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" /label="downshifts" promotor_-35 655151..655158 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 655172..655191 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 655182 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" downshifts 655275 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 655362..655371 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 655385..655404 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 655388 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(655392..655410) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(655412) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(655426..655431) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 655427..655864 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" /label="cotK CDS" gene 655427..655864 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /label="cotK gene" downshifts complement(655434) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" /label="downshifts" downshifts 655864 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 655924..655931 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 655947..655966 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 655952 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="upshifts" CDS 655979..656563 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" /label="yezE CDS" gene 655979..656563 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /label="yezE gene" downshifts 656544 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 656642..657085 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" /label="yesE CDS" gene 656642..657085 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /label="yesE gene" CDS 657082..657942 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" /label="yesF CDS" gene 657082..657942 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /label="yesF gene" promotor_-35 658004..658009 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 658025..658043 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 658025 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(658047..658061) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(658052) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(658069..658073) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 658069..658317 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" /label="cotJA CDS" gene 658069..658317 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /label="cotJA gene" CDS 658301..658564 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" /label="cotJB CDS" gene 658301..658564 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /label="cotJB gene" CDS 658579..659148 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" /label="cotJC CDS" gene 658579..659148 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /label="cotJC gene" S_feature 659149..659227 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 659200..659205 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 659220..659239 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 659229 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="upshifts" CDS 659273..659815 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" /label="yesJ CDS" gene 659273..659815 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /label="yesJ gene" downshifts 659782 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS 659838..660140 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" /label="yesK CDS" gene 659838..660140 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /label="yesK gene" promotor_-35 660183..660191 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 660202..660220 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 660208 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="upshifts" CDS 660255..660884 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" /label="yesL CDS" gene 660255..660884 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /label="yesL gene" CDS 660881..662614 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" /label="yesM CDS" gene 660881..662614 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /label="yesM gene" CDS 662614..663720 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" /label="yesN CDS" gene 662614..663720 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /label="yesN gene" downshifts 663674 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" promotor_-35 663759..663762 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 663777..663796 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 663784 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 663824..665107 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" /label="yesO CDS" gene 663824..665107 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /label="yesO gene" CDS 665104..666033 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" /label="rhgP CDS" gene 665104..666033 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /label="rhgP gene" CDS 666037..666927 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" /label="rhgQ CDS" gene 666037..666927 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /label="rhgQ gene" CDS 666943..667977 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" /label="rhgH CDS" gene 666943..667977 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /label="rhgH gene" CDS 668000..670285 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" /label="rhgR CDS" gene 668000..670285 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /label="rhgR gene" CDS 670299..670997 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" /label="rhgT CDS" gene 670299..670997 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /label="rhgT gene" CDS 670990..671652 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" /label="yesU CDS" gene 670990..671652 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /label="yesU gene" CDS 671649..672275 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" /label="yesV CDS" gene 671649..672275 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /label="yesV gene" CDS 672396..674258 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" /label="rhgW CDS" gene 672396..674258 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /label="rhgW gene" promotor_no_box 672436..672536 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 672496 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(673034) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(673035..673054) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(673067..673076) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 674304..676142 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" /label="rhgX CDS" gene 674304..676142 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /label="rhgX gene" CDS 676300..676953 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " /label="yesY CDS" gene 676300..676953 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /label="yesY gene" CDS 676961..678952 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" /label="rhgZ CDS" gene 676961..678952 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /label="rhgZ gene" CDS 678996..681569 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" /label="yetA CDS" gene 678996..681569 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /label="yetA gene" promotor_-10 complement(680318..680336) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(680331) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(680352..680357) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 681691..683199 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" /label="lplA CDS" gene 681691..683199 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /label="lplA gene" CDS 683254..684210 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" /label="lplB CDS" gene 683254..684210 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /label="lplB gene" downshifts complement(683528) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(683554..683654) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(683594) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 684224..685111 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" /label="lplC CDS" gene 684224..685111 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /label="lplC gene" promotor_-35 684858..684863 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 684879..684897 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 684882 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="upshifts" CDS 685120..686460 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" /label="lplD CDS" gene 685120..686460 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /label="lplD gene" S_feature complement(685554..687245) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 686461..686542 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 686543..687238 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" /label="yetF CDS" gene 686543..687238 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /label="yetF gene" downshifts 687236 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(687275..687601) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" /label="hmoA CDS" gene complement(687275..687601) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /label="hmoA gene" downshifts complement(687290) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 687588 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(687624..687643) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(687642) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(687658..687665) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(687705..688067) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" /label="yetH CDS" gene complement(687705..688067) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /label="yetH gene" promotor_-10 complement(688090..688109) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(688104) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="upshifts" promotor_-35 complement(688122..688128) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(688138..688698) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(688170) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(688681..688700) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(688698) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(688714..688723) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 688786..688793 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 688802 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 688806..688825 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 688851..689432 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" /label="yetI CDS" gene 688851..689432 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo /label="yetI gene" CDS 689426..689722 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" /label="yetI CDS" gene 689426..689722 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo /label="yetI gene" downshifts 689714 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 689793..689800 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 689814..689833 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 689822 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 689877..690044 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" /label="yezD CDS" gene 689877..690044 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /label="yezD gene" promotor_-35 690086..690093 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 690109..690128 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 690110 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 690154..690798 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" /label="calJ CDS" gene 690154..690798 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /label="calJ gene" downshifts 690734 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" /label="downshifts" downshifts 690778 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" CDS 690798..691790 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" /label="yetK CDS" gene 690798..691790 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /label="yetK gene" downshifts 691724 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 691768 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(691814..692317) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" /label="flvL CDS" gene complement(691814..692317) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /label="flvL gene" promotor_-10 complement(692342..692361) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(692350) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(692375..692382) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 692480..693589 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" /label="flvM CDS" gene 692480..693589 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /label="flvM gene" downshifts 693572 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS complement(693624..694694) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" /label="yetN CDS" gene complement(693624..694694) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /label="yetN gene" downshifts complement(693648) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(694725..694744) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(694751) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(694759..694766) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 694774..694780 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 694795..694813 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 694804 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="upshifts" CDS 694844..698029 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" /label="cypD CDS" gene 694844..698029 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /label="cypD gene" downshifts 698016 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 698079..698084 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 698100..698118 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 698121 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 698149..698152 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 698169..698188 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 698170..698475 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 698170 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" CDS 698476..700395 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" /label="ltaSA CDS" gene 698476..700395 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /label="ltaSA gene" downshifts 700394 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 700483..700492 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 700502..700630 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 700502 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 700506..700525 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(700556) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" /label="downshifts" CDS 700631..701395 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" /label="spmH CDS" gene 700631..701395 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /label="spmH gene" CDS 701402..702370 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" /label="spmG CDS" gene 701402..702370 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /label="spmG gene" CDS 702394..703305 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" /label="yfnF CDS" gene 702394..703305 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /label="yfnF gene" promotor_-35 703183..703192 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 703205..703224 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 703208 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" CDS 703334..704512 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" /label="yfnE CDS" gene 703334..704512 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /label="yfnE gene" promotor_-35 704053..704059 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 704074..704093 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 704088 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 704513..705448 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" /label="yfnD CDS" gene 704513..705448 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /label="yfnD gene" downshifts 705320 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 705430 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(705471) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" /label="downshifts" CDS complement(705479..706708) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" /label="yfnC CDS" gene complement(705479..706708) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /label="yfnC gene" promotor_-10 complement(706737..706756) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(706755) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(706772..706779) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(706819..707526) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" /label="pynN CDS" gene complement(706819..707526) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /label="pynN gene" downshifts complement(706848) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(707549..707568) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(707572) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(707618..709003) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" /label="mtrA CDS" gene complement(707618..709003) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /label="mtrA gene" downshifts complement(707640) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(709052..709071) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(709069) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(709086..709093) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 709171..709178 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 709186 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 709192..709210 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 709253..710710 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" /label="vdhT CDS" gene 709253..710710 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /label="vdhT gene" promotor_-10 complement(710046..710065) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(710060) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(710078..710087) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 710724..711584 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" /label="yfmS CDS" gene 710724..711584 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /label="yfmS gene" downshifts 711568 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 711652..711659 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 711673..711692 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 711678 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="upshifts" CDS 711719..713608 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" /label="ettA CDS" gene 711719..713608 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /label="ettA gene" downshifts 713592 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" misc_feature 713672..713691 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 713680 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="upshifts" CDS 713731..714177 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" /label="yfmQ CDS" gene 713731..714177 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /label="yfmQ gene" downshifts complement(713733) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(713817..713820) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(713822) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(713838..713839) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 714164 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 714240..714247 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 714261..714280 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 714273 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="upshifts" CDS 714302..714724 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" /label="copP CDS" gene 714302..714724 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /label="copP gene" downshifts 714560 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS 714790..715980 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" /label="copO CDS" gene 714790..715980 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /label="copO gene" downshifts complement(716044) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS 716271..716426 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" /label="yfmN CDS" gene 716271..716426 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /label="yfmN gene" CDS complement(716546..718102) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" /label="ettM CDS" gene complement(716546..718102) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /label="ettM gene" downshifts complement(716570) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 717932..717938 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 717953..717964 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 717970 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(718152..718171) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(718156) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(718187..718191) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 718212..718215 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 718231..718250 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 718234 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" CDS 718275..719405 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" /label="yfmL CDS" gene 718275..719405 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /label="yfmL gene" downshifts 719388 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS 719473..719919 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" /label="yfmK CDS" gene 719473..719919 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /label="yfmK gene" CDS complement(719972..720991) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" /label="yfmJ CDS" gene complement(719972..720991) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /label="yfmJ gene" downshifts complement(719982) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(721012..721031) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(721016) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(721018..721472) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(721044..721051) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 721110..721117 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 721131..721150 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 721138..722235 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 721138 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="upshifts" CDS complement(721473..722693) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" /label="yfmI CDS" gene complement(721473..722693) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /label="yfmI gene" promotor_-10 complement(722730..722749) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(722737) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(722765..722772) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 722791..722798 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 722810..722985 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 722810 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 722813..722832 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 722942 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 723029..724492 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" /label="yfmG CDS" gene 723029..724492 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /label="yfmG gene" S_feature complement(723394..725064) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 724493..724986 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 724974..724979 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 724988..728253 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 724988 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 724995..725013 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(725065..725865) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" /label="fecF CDS" gene complement(725065..725865) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /label="fecF gene" CDS complement(725878..726879) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " /label="fecE CDS" gene complement(725878..726879) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /label="fecE gene" promotor_-10 complement(726465..726484) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(726477) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(726499..726506) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(726876..727877) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " /label="fecD CDS" gene complement(726876..727877) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /label="fecD gene" misc_feature complement(727947..727966) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(727949..728896) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" /label="fecC CDS" gene complement(727949..728896) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /label="fecC gene" downshifts complement(727968) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" upshifts complement(727968) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 728223..728228 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 728244..728262 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 728255..728880 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 728255 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="upshifts" misc_feature 728876..728895 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 728882..729413 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 728882 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(728938..728957) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(728945) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(728971..728978) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(729005..729373) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" /label="yfmB CDS" gene complement(729005..729373) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /label="yfmB gene" S_feature complement(729374..729486) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(729475..729494) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(729486) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="upshifts" promotor_-35 complement(729506..729513) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 729554..729560 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 729574..729592 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 729574 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 729617..729964 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" /label="yflT CDS" gene 729617..729964 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /label="yflT gene" downshifts complement(729618) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" downshifts 729960 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 730005..730085 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 730086..730105 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 730087 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="upshifts" CDS 730155..731417 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" /label="pelA CDS" gene 730155..731417 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /label="pelA gene" downshifts 731412 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-35 731470..731473 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 731488..731507 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 731496 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 731544..732980 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" /label="maeS CDS" gene 731544..732980 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /label="maeS gene" downshifts 732972 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature 733071..733090 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 733082 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="upshifts" CDS 733107..734735 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" /label="citS CDS" gene 733107..734735 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /label="citS gene" CDS 734707..735387 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" /label="citT CDS" gene 734707..735387 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /label="citT gene" CDS 735390..736349 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" /label="yflP CDS" gene 735390..736349 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /label="yflP gene" downshifts 736318 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 736441..736448 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 736461..736480 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 736472..736544 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 736472 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="upshifts" CDS 736545..737846 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" /label="citM CDS" gene 736545..737846 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /label="citM gene" promotor_-35 737843..737849 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 737863..737874 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 737864 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="upshifts" CDS 737902..738696 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" /label="yflN CDS" gene 737902..738696 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /label="yflN gene" downshifts 738672 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-35 738751..738754 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 738769..738788 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 738782 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="upshifts" CDS 738815..739906 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" /label="nosA CDS" gene 738815..739906 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /label="nosA gene" CDS complement(739897..740172) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" /label="acyP CDS" gene complement(739897..740172) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /label="acyP gene" S_feature 739907..740238 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(740186..740205) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(740200) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(740220..740227) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 740239..740904 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" /label="yflK CDS" gene 740239..740904 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /label="yflK gene" CDS complement(740945..741082) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" /label="yflJ CDS" gene complement(740945..741082) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /label="yflJ gene" downshifts complement(740959) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(741083..741213) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(741199..741217) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 741209..741214 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(741213) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 741224..742288 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 741225 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 741230..741248 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(741233..741238) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(741239..741394) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" /label="yflI CDS" gene complement(741239..741394) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /label="yflI gene" S_feature complement(741395..741500) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(741501..741815) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" /label="yflH CDS" gene complement(741501..741815) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /label="yflH gene" S_feature complement(741816..741896) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(741897..742646) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" /label="mapB CDS" gene complement(741897..742646) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /label="mapB gene" promotor_-10 complement(742675..742694) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(742688) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(742690..743826) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(742706..742714) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 742757..742758 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 742778..742797 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 742781 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="upshifts" CDS 742818..744176 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" /label="nagP CDS" gene 742818..744176 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /label="nagP gene" promotor_-10 complement(743812..743831) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(743826) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(743845..743854) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 744062 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 744172 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(744209..746158) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" /label="ltaSB CDS" gene complement(744209..746158) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /label="ltaSB gene" downshifts complement(744226) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 745268..745274 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 745290..745308 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 745294..746258 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 745294 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(746159..746233) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(746210..746229) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(746233) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(746235..746757) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(746245..746249) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 746259..746396 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" /label="yflD CDS" gene 746259..746396 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /label="yflD gene" upshifts 746374 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="upshifts" misc_feature 746375..746394 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 746415..746807 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" /label="yflB CDS" gene 746415..746807 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /label="yflB gene" promotor_-10 complement(746755..746773) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(746770) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(746789..746794) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 746876..746882 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 746897..746915 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 746897 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="upshifts" CDS 746932..748347 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" /label="yflA CDS" gene 746932..748347 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /label="yflA gene" downshifts complement(746933) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(746959..747059) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(746999) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(748344..749420) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" /label="yfkT CDS" gene complement(748344..749420) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /label="yfkT gene" S_feature 748348..751714 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(749444..749644) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" /label="yfkS CDS" gene complement(749444..749644) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /label="yfkS gene" CDS complement(749660..750814) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" /label="yfkR CDS" gene complement(749660..750814) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /label="yfkR gene" CDS complement(750795..752336) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" /label="yfkQ CDS" gene complement(750795..752336) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /label="yfkQ gene" promotor_-10 complement(752386..752397) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(752389) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(752411..752417) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 752446..752453 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 752468..752487 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 752475 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(752521) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 752529..753941 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" /label="treP CDS" gene 752529..753941 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /label="treP gene" promotor_no_box complement(752547..752647) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(752587) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 754012..755697 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" /label="treA CDS" gene 754012..755697 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /label="treA gene" promotor_-10 complement(754318..754333) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(754325) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(754346..754355) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 755670..755674 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 755690..755709 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 755693 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 755718..756434 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" /label="treR CDS" gene 755718..756434 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /label="treR gene" downshifts 756427 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" promotor_-35 756509..756512 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 756528..756547 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 756537 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 756574..757239 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" /label="hypO CDS" gene 756574..757239 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /label="hypO gene" downshifts 757220 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(757276..761664) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" /label="yfkN CDS" gene complement(757276..761664) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /label="yfkN gene" downshifts complement(757295) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(761697..761716) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(761714) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(761731..761734) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 761841..761847 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 761861..761879 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 761864 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 761907..762425 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" /label="sufLB CDS" gene 761907..762425 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /label="sufLB gene" downshifts 762411 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" /label="downshifts" downshifts complement(762455) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" /label="downshifts" S_feature 762456..764106 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(762465..763655) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" /label="yfkL CDS" gene complement(762465..763655) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /label="yfkL gene" S_feature complement(763656..763747) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(763748..763963) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" /label="yfkK CDS" gene complement(763748..763963) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /label="yfkK gene" downshifts complement(763807) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(763995..764014) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(764009) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(764029..764030) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 764076..764083 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 764098..764117 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 764108 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 764166..764636 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" /label="yfkJ CDS" gene 764166..764636 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /label="yfkJ gene" CDS 764654..764974 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" /label="yfkI CDS" gene 764654..764974 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /label="yfkI gene" CDS 764998..765825 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " /label="rbn CDS" gene 764998..765825 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /label="rbn gene" promotor_-35 765804..765810 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 765825..765836 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 765843..765999 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 765843 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(765875) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" /label="downshifts" downshifts 765974 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(766024..767199) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " /label="yfkF CDS" gene complement(766024..767199) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /label="yfkF gene" downshifts complement(766029) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" /label="downshifts" promotor_-35 766636..766642 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 766658..766676 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 766662..767315 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 766662 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(767224..767243) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(767239) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(767257..767264) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 767305..767310 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 767317 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 767325..767343 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 767367..768422 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" /label="chaA CDS" gene 767367..768422 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /label="chaA gene" promotor_-35 768436..768442 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 768457..768468 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 768461 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="upshifts" CDS 768493..769287 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" /label="yfkD CDS" gene 768493..769287 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /label="yfkD gene" downshifts 769275 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(769326..770168) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" /label="mscC CDS" gene complement(769326..770168) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /label="mscC gene" downshifts complement(769328) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(770169..771290) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" /label="yfkA CDS" gene complement(770169..771290) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /label="yfkA gene" promotor_-10 complement(771331..771350) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(771349) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(771366..771370) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 771378..771385 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 771399..771418 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 771409 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="upshifts" CDS 771435..771620 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" /label="yfjT CDS" gene 771435..771620 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /label="yfjT gene" downshifts 771599 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" /label="downshifts" promotor_-35 771663..771669 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 771675 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 771684..771695 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 771721..772512 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" /label="pdaA CDS" gene 771721..772512 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /label="pdaA gene" downshifts 772510 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(772550..773410) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" /label="yfjR CDS" gene complement(772550..773410) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /label="yfjR gene" downshifts complement(772564) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(773430..773449) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(773444) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(773465..773468) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(773509..774468) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" /label="yfjQ CDS" gene complement(773509..774468) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /label="yfjQ gene" downshifts complement(773532) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(774479..774498) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(774482) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(774514..774517) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 774529..774533 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 774547..774566 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 774556 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="upshifts" CDS 774587..775450 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" /label="yfjP CDS" gene 774587..775450 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /label="yfjP gene" S_feature 775451..775563 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 775564..776964 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" /label="yfjO CDS" gene 775564..776964 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /label="yfjO gene" downshifts 776976 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 777270..777277 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 777293..777312 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 777299 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="upshifts" S_feature 777306..777589 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 777590..777856 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" /label="yfzA CDS" gene 777590..777856 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /label="yfzA gene" promotor_-10 complement(777804..777823) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(777822) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(777838..777841) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 777857..778338 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 778309..778312 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 778329..778348 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 778340..778587 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 778340 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 778588..779565 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" /label="dusC CDS" gene 778588..779565 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /label="dusC gene" S_feature 779566..779658 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 779615 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" /label="downshifts" promotor_-35 779699..779705 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 779717..779736 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 779726 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 779761..780213 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" /label="yfjM CDS" gene 779761..780213 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /label="yfjM gene" CDS 780243..780932 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" /label="yfjL CDS" gene 780243..780932 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /label="yfjL gene" downshifts 780937 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" /label="downshifts" misc_feature 781109..781127 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 781116 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 781164..782165 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " /label="acoA CDS" gene 781164..782165 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /label="acoA gene" CDS 782169..783197 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" /label="acoB CDS" gene 782169..783197 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /label="acoB gene" CDS 783211..784407 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" /label="acoC CDS" gene 783211..784407 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /label="acoC gene" downshifts complement(783212) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" /label="downshifts" CDS 784428..785804 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" /label="acoL CDS" gene 784428..785804 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /label="acoL gene" downshifts 785798 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" /label="downshifts" promotor_-35 785851..785858 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 785871..785890 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 785879 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 785920..787737 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" /label="acoR CDS" gene 785920..787737 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /label="acoR gene" promotor_-35 787738..787744 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 787756 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 787759..787770 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 787791..787970 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" /label="sspH CDS" gene 787791..787970 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /label="sspH gene" downshifts 787954 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(788006..788335) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" /label="yfjF CDS" gene complement(788006..788335) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /label="yfjF gene" downshifts complement(788020) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(788385..788843) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" /label="yfjE CDS" gene complement(788385..788843) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /label="yfjE gene" S_feature complement(788844..788936) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(788937..789494) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" /label="yfjD CDS" gene complement(788937..789494) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /label="yfjD gene" promotor_-35 789360..789365 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 789373 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 789380..789398 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 789384..789971 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(789526..790293) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" /label="yfjC CDS" gene complement(789526..790293) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /label="yfjC gene" CDS complement(790305..791528) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" /label="yfjB CDS" gene complement(790305..791528) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /label="yfjB gene" CDS complement(791534..791848) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" /label="yfjA CDS" gene complement(791534..791848) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /label="yfjA gene" promotor_-10 complement(791896..791915) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(791909) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(791930..791933) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 792140..792159 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 792143 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="upshifts" CDS 792184..793533 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " /label="malA CDS" gene 792184..793533 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /label="malA gene" misc_feature 793562..793581 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 793564 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="upshifts" CDS 793598..794362 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" /label="malR CDS" gene 793598..794362 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /label="malR gene" promotor_-10 complement(793742..793756) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(793772..793778) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(793772) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 794377..795960 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" /label="malP CDS" gene 794377..795960 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /label="malP gene" downshifts 795940 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" /label="downshifts" promotor_-35 795989..795996 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 796011..796030 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 796019 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="upshifts" CDS 796066..797787 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" /label="yfiB CDS" gene 796066..797787 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /label="yfiB gene" CDS 797781..799595 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" /label="yfiC CDS" gene 797781..799595 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /label="yfiC gene" downshifts 799570 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 799677..799684 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 799698..799717 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 799702 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="upshifts" CDS 799750..800154 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" /label="catD CDS" gene 799750..800154 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /label="catD gene" CDS 800172..801029 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" /label="catE CDS" gene 800172..801029 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /label="catE gene" downshifts 801016 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS 801123..802067 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" /label="yfiF CDS" gene 801123..802067 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /label="yfiF gene" downshifts complement(801934) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(801982..802082) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(802022) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 802242..803690 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" /label="yfiG CDS" gene 802242..803690 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /label="yfiG gene" CDS 803717..804658 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" /label="yfiH CDS" gene 803717..804658 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /label="yfiH gene" CDS 804668..805849 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" /label="yfiI CDS" gene 804668..805849 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /label="yfiI gene" downshifts 805839 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" /label="downshifts" promotor_-35 805909..805915 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 805930..805949 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 805948 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="upshifts" CDS 805973..807175 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" /label="linJ CDS" gene 805973..807175 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /label="linJ gene" CDS 807172..807834 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" /label="linK CDS" gene 807172..807834 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /label="linK gene" downshifts 807842 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 807978..808913 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" /label="bifL CDS" gene 807978..808913 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /label="bifL gene" CDS 808926..810116 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" /label="bifM CDS" gene 808926..810116 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /label="bifM gene" CDS 810130..811287 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" /label="bifN CDS" gene 810130..811287 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /label="bifN gene" promotor_-35 810241..810246 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 810261..810279 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 810262 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(811285..811359) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(811328) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(811360..811908) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" /label="padR CDS" gene complement(811360..811908) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /label="padR gene" S_feature complement(811909..811988) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(811977..811996) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(811988) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(812010..812015) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 812111..812114 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 812130..812149 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 812137 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="upshifts" CDS 812181..812813 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" /label="estB CDS" gene 812181..812813 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /label="estB gene" downshifts 812792 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" /label="downshifts" promotor_-35 812928..812933 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 812947..812966 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 812957 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="upshifts" CDS 813002..814090 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" /label="icaC CDS" gene 813002..814090 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /label="icaC gene" S_feature complement(813492..813880) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(813880) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(813882..813901) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(813914..813922) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(814126..814743) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" /label="yfiR CDS" gene complement(814126..814743) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /label="yfiR gene" downshifts complement(814144) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(814709..815962) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" /label="yfiS CDS" gene complement(814709..815962) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /label="yfiS gene" promotor_-10 complement(814770..814789) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(814782) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(814803..814810) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(815996..816015) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(816014) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(816030..816037) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 816041..816060 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 816046 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="upshifts" CDS 816086..816622 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" /label="bstA CDS" gene 816086..816622 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /label="bstA gene" CDS complement(816619..818175) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" /label="yfiU CDS" gene complement(816619..818175) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /label="yfiU gene" promotor_-10 complement(818197..818215) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(818214) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(818231..818234) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(818286..818768) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" /label="yfiV CDS" gene complement(818286..818768) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /label="yfiV gene" downshifts complement(818302) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(818793..818812) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(818809) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(818827..818833) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 818854..818861 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 818875..818894 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 818883 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="upshifts" CDS 818940..821510 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" /label="mprF CDS" gene 818940..821510 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /label="mprF gene" downshifts 821481 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(821528..822505) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" /label="sxzY CDS" gene complement(821528..822505) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /label="sxzY gene" downshifts complement(821539) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 822520..822527 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(822532..822551) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 822542..822561 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 822544..822635 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 822544 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(822549) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(822566..822573) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 822636..823637 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " /label="sxzZ CDS" gene 822636..823637 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /label="sxzZ gene" CDS 823634..824665 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" /label="sxzA CDS" gene 823634..824665 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /label="sxzA gene" downshifts 824646 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 824716..824718 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 824734..824753 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 824737 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 824780..825661 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" /label="yfhB CDS" gene 824780..825661 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /label="yfhB gene" promotor_-35 825672..825679 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 825695..825714 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 825704 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 825749..826333 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" /label="yfhC CDS" gene 825749..826333 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /label="yfhC gene" downshifts 826320 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(826372..826563) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" /label="yfhD CDS" gene complement(826372..826563) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /label="yfhD gene" downshifts complement(826390) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" /label="downshifts" upshifts complement(826595) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(826598..826609) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(826624..826630) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(826630..826740) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" /label="yfhE CDS" gene complement(826630..826740) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /label="yfhE gene" promotor_-10 complement(826769..826780) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(826771) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(826795..826801) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(826795..827706) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" /label="yfhF CDS" gene complement(826795..827706) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /label="yfhF gene" promotor_-35 827592..827595 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 827612..827631 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 827622..827794 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 827622 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(827728..827746) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(827742) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(827760..827766) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 827795..828589 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" /label="recX CDS" gene 827795..828589 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /label="recX gene" CDS 828591..828905 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" /label="yfhH CDS" gene 828591..828905 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /label="yfhH gene" S_feature complement(828813..829081) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 828895 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 828979..828984 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 829000..829019 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 829005 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" CDS 829048..830241 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" /label="yfhI CDS" gene 829048..830241 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /label="yfhI gene" S_feature 830242..830476 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(830274..830426) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" /label="sspK CDS" gene complement(830274..830426) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /label="sspK gene" downshifts complement(830291) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 830455..830462 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 830476..830495 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 830478..830550 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 830478 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(830485..830496) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(830495) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(830511..830517) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 830551..830820 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" /label="yfhJ CDS" gene 830551..830820 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /label="yfhJ gene" downshifts 830809 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 830898..830904 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 830919 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 830920..830938 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 830965..831483 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" /label="yfhK CDS" gene 830965..831483 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /label="yfhK gene" S_feature 831484..831551 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 831519..831528 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 831540..831555 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 831553 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="upshifts" CDS 831568..831900 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" /label="spdL CDS" gene 831568..831900 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /label="spdL gene" CDS 831887..832747 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" /label="ephM CDS" gene 831887..832747 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /label="ephM gene" downshifts 832745 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 832805..832811 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 832825..832836 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 832833..832897 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 832833 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(832855..832874) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(832864) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 832880..832886 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(832888..832889) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 832899..832979 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 832899 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 832901..832919 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 832980..833969 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" /label="csbB CDS" gene 832980..833969 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /label="csbB gene" upshifts complement(833129) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(833134..833138) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(833155..833159) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 833970..834040 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 834041..836626 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" /label="yfhO CDS" gene 834041..836626 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /label="yfhO gene" downshifts 836595 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(836619..837602) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" /label="yfhP CDS" gene complement(836619..837602) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /label="yfhP gene" downshifts complement(836653) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 837076..837085 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 837098..837117 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 837102 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(837603..837750) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 837707..837711 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 837727..837746 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 837734 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 837740..837817 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(837748..837767) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(837750) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(837782..837789) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 837818..838927 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" /label="mutY CDS" gene 837818..838927 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /label="mutY gene" promotor_-35 838764..838768 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 838784..838803 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 838796 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 838928..839240 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(838935..839159) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" /label="yfhS CDS" gene complement(838935..839159) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /label="yfhS gene" promotor_-10 complement(839189..839200) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(839191) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(839214..839220) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 839241..839993 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" /label="fabL CDS" gene 839241..839993 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /label="fabL gene" promotor_-35 840010..840016 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 840031..840042 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 840032 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(840039..840053) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(840060) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(840062..840066) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 840062..840316 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" /label="sspE CDS" gene 840062..840316 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /label="sspE gene" downshifts 840314 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(840339) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" /label="downshifts" CDS 840405..840749 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" /label="ygaB CDS" gene 840405..840749 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /label="ygaB gene" promotor_-35 840412..840420 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 840431..840449 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 840433 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="upshifts" downshifts 840732 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 840788..840795 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 840809..840828 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 840818..840892 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 840818 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="upshifts" CDS 840893..841423 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" /label="ygaC CDS" gene 840893..841423 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /label="ygaC gene" downshifts 841414 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 841511..843253 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" /label="ygaD CDS" gene 841511..843253 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /label="ygaD gene" downshifts 843240 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(843330..844391) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" /label="ygaE CDS" gene complement(843330..844391) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /label="ygaE gene" downshifts complement(843341) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature complement(844392..844482) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(844480..844499) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(844489) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(844514..844521) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(844611..845900) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" /label="gsaB CDS" gene complement(844611..845900) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /label="gsaB gene" downshifts complement(844614) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(845928..845947) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(845947) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(845949..846660) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(845959..845964) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 845993..846000 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 846014..846033 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 846014 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="upshifts" CDS 846053..846526 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" /label="bcp CDS" gene 846053..846526 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /label="bcp gene" promotor_-35 846563..846570 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 846585..846604 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 846591 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="upshifts" CDS 846649..847086 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" /label="perR CDS" gene 846649..847086 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /label="perR gene" downshifts 847068 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(847121..847474) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" /label="ygzB CDS" gene complement(847121..847474) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /label="ygzB gene" downshifts 847134 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(847144) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 847470..847474 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 847482..847496 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(847486..847505) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 847486..847577 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 847486 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="upshifts" upshifts complement(847496) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 847554..847557 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 847572..847591 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 847579..847681 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 847579 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="upshifts" CDS 847682..848566 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" /label="ygxA CDS" gene 847682..848566 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /label="ygxA gene" promotor_-35 848549..848556 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 848570..848589 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 848585..848857 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 848585 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(848618) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" rRNA 848858..850412 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-16S rRNA" gene 848858..850412 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /label="rrnD-16S gene" rRNA 850580..853507 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-23S rRNA" gene 850580..853507 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /label="rrnD-23S gene" S_feature 853508..853593 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 853569..853576 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 853590..853609 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 853595 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="upshifts" rRNA 853619..853734 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-5S rRNA" gene 853619..853734 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /label="rrnD-5S gene" tRNA 853744..853818 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="asnTA tRNA" gene 853744..853818 /gene="asnTA" /locus_tag="BSU_tRNA_29" /label="asnTA gene" tRNA 853824..853915 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Ser tRNA" gene 853824..853915 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /label="trnD-Ser gene" downshifts 853911 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" tRNA 853950..854021 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Glu tRNA" gene 853950..854021 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /label="trnD-Glu gene" tRNA 854031..854106 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Val tRNA" gene 854031..854106 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /label="trnD-Val gene" tRNA 854116..854192 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Met tRNA" gene 854116..854192 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /label="trnD-Met gene" tRNA 854204..854280 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Asp tRNA" gene 854204..854280 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /label="trnD-Asp gene" tRNA 854293..854368 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Phe tRNA" gene 854293..854368 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /label="trnD-Phe gene" tRNA 854374..854446 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Thr tRNA" gene 854374..854446 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /label="trnD-Thr gene" tRNA 854469..854553 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Tyr tRNA" gene 854469..854553 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /label="trnD-Tyr gene" tRNA 854559..854632 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Trp tRNA" gene 854559..854632 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /label="trnD-Trp gene" tRNA 854657..854732 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-His tRNA" gene 854657..854732 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /label="trnD-His gene" tRNA 854742..854813 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Gln tRNA" gene 854742..854813 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /label="trnD-Gln gene" tRNA 854863..854937 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="glyTB tRNA" gene 854863..854937 /gene="glyTB" /locus_tag="BSU_tRNA_41" /label="glyTB gene" tRNA 854943..855013 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="cysTA tRNA" gene 854943..855013 /gene="cysTA" /locus_tag="BSU_tRNA_42" /label="cysTA gene" tRNA 855021..855109 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTA tRNA" gene 855021..855109 /gene="leuTA" /locus_tag="BSU_tRNA_43" /label="leuTA gene" S_feature 855110..855186 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 855143 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature 855188..855356 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 855313..855320 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 855319 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 855334..855353 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 855358 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="upshifts" tRNA 855375..855456 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTB tRNA" gene 855375..855456 /gene="leuTB" /locus_tag="BSU_tRNA_44" /label="leuTB gene" promotor_-10 complement(855392..855409) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(855395) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(855430..855435) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(855465) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" /label="downshifts" CDS complement(855535..856311) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" /label="spo0M CDS" gene complement(855535..856311) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /label="spo0M gene" downshifts complement(855549) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(856338..856353) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(856360) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(856366..856375) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 856395..856401 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 856416..856427 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 856419 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="upshifts" CDS 856453..856656 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" /label="ygzA CDS" gene 856453..856656 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /label="ygzA gene" downshifts 856639 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(856715) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(856741..857013) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" /label="ygzC CDS" gene complement(856741..857013) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /label="ygzC gene" promotor_-10 complement(856972..856990) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(856979) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 856994..857001 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(857007..857012) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 857014..857033 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 857022 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="upshifts" CDS 857055..857747 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" /label="ygaJ CDS" gene 857055..857747 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /label="ygaJ gene" promotor_-35 857776..857780 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(857779..857798) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(857791) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 857794..857813 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(857813..857820) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 857817..857924 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswD RNA" gene 857817..857924 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /label="tswD gene" upshifts 857824 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="upshifts" downshifts 857955 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" /label="downshifts" CDS 858057..859829 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" /label="thiC CDS" gene 858057..859829 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /label="thiC gene" downshifts 859805 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature 859850..860775 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(859867..861222) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" /label="ygaK CDS" gene complement(859867..861222) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /label="ygaK gene" promotor_-10 complement(861250..861269) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(861267) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(861283..861292) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 861340..861346 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 861361..861380 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 861389 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="upshifts" CDS 861473..861670 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" /label="senS CDS" gene 861473..861670 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /label="senS gene" CDS complement(861697..863148) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" /label="katA CDS" gene complement(861697..863148) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /label="katA gene" downshifts complement(861707) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 863125..863131 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 863146..863165 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 863149 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(863166..863185) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 863171..863500 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(863185) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(863199..863206) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(863244..863262) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(863269) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" downshifts 863457 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" CDS 863556..864323 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" /label="ssuB CDS" gene 863556..864323 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /label="ssuB gene" CDS 864341..865339 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" /label="ssuA CDS" gene 864341..865339 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /label="ssuA gene" CDS 865336..866166 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" /label="ssuC CDS" gene 865336..866166 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /label="ssuC gene" CDS 866189..867319 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" /label="ssuD CDS" gene 866189..867319 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /label="ssuD gene" misc_feature 867346..867365 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 867352 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="upshifts" CDS 867423..867959 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" /label="ygaN CDS" gene 867423..867959 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /label="ygaN gene" S_feature 867960..868030 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 868000..868007 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 868021..868040 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 868032 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="upshifts" CDS 868071..868340 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" /label="rpsNB CDS" gene 868071..868340 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /label="rpsNB gene" promotor_-35 868143..868147 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 868170..868186 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 868186 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 868327 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(868358..868831) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" /label="ygaO CDS" gene complement(868358..868831) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /label="ygaO gene" downshifts complement(868394) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(868833..869033) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" /label="ygzD CDS" gene complement(868833..869033) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /label="ygzD gene" promotor_-10 complement(869062..869081) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(869076) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(869094..869101) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 869157..869162 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 869176..869195 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 869176 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="upshifts" tRNA 869227..869300 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gly1 tRNA" gene 869227..869300 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /label="trnSL-Gly1 gene" S_feature 869301..869483 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(869391..870014) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" /label="yhzB CDS" gene complement(869391..870014) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /label="yhzB gene" downshifts complement(869406) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 869440 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature 869485..870096 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(870038..870057) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(870059) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(870071..870078) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 870097..871257 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" /label="queG CDS" gene 870097..871257 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /label="queG gene" downshifts 871266 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 871283..871295 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 871288 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="upshifts" CDS 871324..872259 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" /label="yhbB CDS" gene 871324..872259 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /label="yhbB gene" downshifts complement(871342) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" /label="downshifts" promotor_-35 872243..872246 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 872261 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 872262..872281 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 872297..872779 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" /label="trmL CDS" gene 872297..872779 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /label="trmL gene" downshifts 872762 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 872829..873545 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" /label="yhbD CDS" gene 872829..873545 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /label="yhbD gene" promotor_-35 872849..872856 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 872871..872890 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 872872 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="upshifts" CDS 873536..874249 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" /label="yhbE CDS" gene 873536..874249 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /label="yhbE gene" CDS 874261..874968 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" /label="yhbF CDS" gene 874261..874968 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /label="yhbF gene" downshifts 874852 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 874896 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 874962 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(874995..875170) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(875038) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(875162..875181) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(875170) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(875196..875203) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 875235..875240 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875256..875274 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 875256 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 875318..877213 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" /label="prkA CDS" gene 875318..877213 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /label="prkA gene" promotor_no_box 875760..875860 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 875820 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 875886 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 877206 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 877270..877275 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877291..877309 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 877294..877392 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 877294 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 877393..878571 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" /label="yhbH CDS" gene 877393..878571 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /label="yhbH gene" promotor_-35 877591..877594 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877609..877628 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 877613 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(877854) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" /label="downshifts" downshifts 878550 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 878658..878665 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 878680..878699 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 878680 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 878731..879195 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" /label="yhbI CDS" gene 878731..879195 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /label="yhbI gene" promotor_-35 879020..879026 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 879041..879059 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 879054 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 879204..879210 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 879224..879235 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 879230 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 879231..879896 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" /label="yhbJ CDS" gene 879231..879896 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /label="yhbJ gene" CDS 879937..881535 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" /label="yhcA CDS" gene 879937..881535 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /label="yhcA gene" CDS 881558..882088 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" /label="yhcB CDS" gene 881558..882088 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /label="yhcB gene" CDS 882101..882475 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" /label="yhcC CDS" gene 882101..882475 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /label="yhcC gene" downshifts 882464 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 882475..882630 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" /label="yhcD CDS" gene 882475..882630 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /label="yhcD gene" promotor_-35 882565..882571 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 882586..882605 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 882596 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="upshifts" CDS 882635..883396 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" /label="yhcE CDS" gene 882635..883396 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /label="yhcE gene" promotor_-10 complement(882948..882966) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(882962) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(882982..882987) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 883399..883764 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" /label="yhcF CDS" gene 883399..883764 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /label="yhcF gene" CDS 883766..884464 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" /label="yhcG CDS" gene 883766..884464 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /label="yhcG gene" CDS 884481..885398 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" /label="yhcH CDS" gene 884481..885398 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /label="yhcH gene" CDS 885391..886332 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" /label="yhcI CDS" gene 885391..886332 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /label="yhcI gene" downshifts 886314 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(886424..886627) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" /label="cspB CDS" gene complement(886424..886627) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /label="cspB gene" downshifts complement(886438) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" /label="downshifts" S_feature complement(886628..886755) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 886715..886726 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 886732 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(886744..886763) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(886755) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(886757..887895) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(886777..886782) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 886922..886929 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 886944..886962 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 886951 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 886952..887062 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 887063..887893 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" /label="yhcJ CDS" gene 887063..887893 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /label="yhcJ gene" downshifts 887852 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(887896..888975) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" /label="dgcK CDS" gene complement(887896..888975) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /label="dgcK gene" promotor_-10 complement(888985..889004) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(889006) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="upshifts" promotor_-35 complement(889020..889024) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 889082..889089 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 889103..889122 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 889109 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="upshifts" CDS 889148..890539 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" /label="tcyP CDS" gene 889148..890539 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /label="tcyP gene" S_feature complement(890175..890578) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 890518 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(890579..891034) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" /label="yhcM CDS" gene complement(890579..891034) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /label="yhcM gene" promotor_-10 complement(891049..891067) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(891077) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(891082..891088) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 891126..891132 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 891146..891157 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 891150 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="upshifts" CDS 891184..891753 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" /label="yhcN CDS" gene 891184..891753 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /label="yhcN gene" promotor_-35 891380..891386 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 891397 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 891400..891411 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 891728 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-35 891796..891805 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 891819..891838 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 891829 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="upshifts" CDS 891874..892842 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" /label="yhcO CDS" gene 891874..892842 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /label="yhcO gene" downshifts 892718 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(892774..893427) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " /label="yhcQ CDS" gene complement(892774..893427) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /label="yhcQ gene" downshifts complement(892791) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(893458..893469) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(893460) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(893484..893490) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 893499..893507 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 893510..897163 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" /label="mncR CDS" gene 893510..897163 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /label="mncR gene" promotor_-10 893518..893536 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 893533 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="upshifts" CDS 897160..897756 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" /label="srtA CDS" gene 897160..897756 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /label="srtA gene" downshifts 897735 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(897786..898694) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" /label="yhcT CDS" gene complement(897786..898694) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /label="yhcT gene" promotor_-35 898750..898758 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(898751..898762) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(898757) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(898759..899245) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 898769 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 898772..898791 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(898776..898782) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 898805..899200 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" /label="yhcU CDS" gene 898805..899200 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /label="yhcU gene" misc_feature complement(899231..899250) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(899245) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 899285..899291 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 899300 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 899305..899316 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(899315..899329) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(899329) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(899337..899341) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 899337..899759 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" /label="yhcV CDS" gene 899337..899759 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /label="yhcV gene" promotor_no_box complement(899663..899763) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(899703) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 899737 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(899769) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" promotor_-35 899809..899816 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 899830..899849 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 899838 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="upshifts" CDS 899886..900548 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" /label="glpW CDS" gene 899886..900548 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /label="glpW gene" CDS 900564..902105 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" /label="yhcX CDS" gene 900564..902105 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /label="yhcX gene" downshifts 902088 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" /label="downshifts" CDS 902189..902380 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" /label="yhzG CDS" gene 902189..902380 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo /label="yhzG gene" promotor_-35 902411..902418 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 902433..902452 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 902444..902525 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 902444 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="upshifts" CDS 902526..903878 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" /label="yhxA CDS" gene 902526..903878 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /label="yhxA gene" CDS 903906..904484 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" /label="glpP CDS" gene 903906..904484 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /label="glpP gene" promotor_-35 904479..904486 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 904501..904520 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 904512 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" downshifts 904527 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" /label="downshifts" S_feature 904572..904662 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 904663..905487 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" /label="glpF CDS" gene 904663..905487 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /label="glpF gene" CDS 905506..906996 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" /label="glpK CDS" gene 905506..906996 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /label="glpK gene" promotor_-35 906307..906313 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 906328..906347 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 906338 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="upshifts" S_feature 906997..907085 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 907042 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 907048..907148 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 907108 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" CDS 907137..908804 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" /label="glpD CDS" gene 907137..908804 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /label="glpD gene" promotor_-35 908566..908571 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 908586..908604 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 908595 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="upshifts" promotor_-35 908649..908655 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 908670 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 908671..908689 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 908772 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" /label="downshifts" S_feature 908817..908890 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 908872..908879 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 908892 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 908893..908912 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 908936..910681 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" /label="pgcA CDS" gene 908936..910681 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /label="pgcA gene" downshifts 910670 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" S_feature 910715..910784 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 910786..910805 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 910786 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" CDS 910830..911969 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" /label="yhcY CDS" gene 910830..911969 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /label="yhcY gene" CDS 911966..912610 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" /label="yhcZ CDS" gene 911966..912610 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /label="yhcZ gene" CDS 912607..913131 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" /label="azr CDS" gene 912607..913131 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /label="azr gene" downshifts 913096 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(913146..913388) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" /label="yhdB CDS" gene complement(913146..913388) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /label="yhdB gene" downshifts complement(913167) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(913424..913435) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(913435) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(913449..913456) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 913523..913529 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 913543..913554 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 913553 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="upshifts" CDS 913589..913912 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" /label="yhdC CDS" gene 913589..913912 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /label="yhdC gene" S_feature 913913..915779 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(913954..915420) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" /label="lytF CDS" gene complement(913954..915420) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /label="lytF gene" downshifts complement(913966) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(914053) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(915460..915478) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(915472) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(915492..915499) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(915573..916013) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" /label="nsrR CDS" gene complement(915573..916013) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /label="nsrR gene" downshifts complement(915603) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" promotor_-35 916001..916007 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 916021..916032 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 916023..916133 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 916023 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(916035..916054) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(916051) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(916066..916072) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 916092 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(916120..917778) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" /label="ygxB CDS" gene complement(916120..917778) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /label="ygxB gene" downshifts complement(916125) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(917669..917687) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(917689) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(917701..917707) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 917750..917755 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 917771..917789 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 917784 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="upshifts" CDS 917809..919215 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" /label="spoVR CDS" gene 917809..919215 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /label="spoVR gene" downshifts 919195 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(919245..920630) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" /label="phoA CDS" gene complement(919245..920630) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /label="phoA gene" downshifts complement(919271) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(920657) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(920659..922190) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(920667..920678) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 920786..920793 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 920806..920825 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 920812..921099 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 920812 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 921062..921065 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 921080..921099 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 921101 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="upshifts" CDS 921160..922164 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" /label="lytE CDS" gene 921160..922164 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /label="lytE gene" downshifts 922026 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 922156 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" upshifts complement(922190) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(922197..922212) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 922202 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(922224..922233) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(922235..923110) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" /label="citR CDS" gene complement(922235..923110) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /label="citR gene" promotor_-35 923163..923164 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(923176..923195) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 923181..923200 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(923182) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="upshifts" upshifts 923191 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(923210..923215) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 923219..924319 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" /label="citA CDS" gene 923219..924319 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /label="citA gene" promotor_-35 924330..924336 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 924351..924369 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 924356 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 924393..925262 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" /label="yhdF CDS" gene 924393..925262 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /label="yhdF gene" downshifts 925270 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 925347..925350 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 925362 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 925365..925384 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 925410..925429 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 925415..925511 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 925415 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" CDS 925512..926909 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" /label="bcaP CDS" gene 925512..926909 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /label="bcaP gene" downshifts 926889 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 926970..926974 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926990..927009 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926997 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 927027..928382 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" /label="yhdH CDS" gene 927027..928382 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /label="yhdH gene" downshifts 928363 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(928417..929826) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" /label="yhdI CDS" gene complement(928417..929826) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /label="yhdI gene" promotor_-35 929875..929878 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 929893..929912 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 929895 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(929897..929916) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(929909) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(929932..929936) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 929936..930364 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" /label="yhdJ CDS" gene 929936..930364 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /label="yhdJ gene" downshifts 930343 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(930395..930685) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" /label="asiMB CDS" gene complement(930395..930685) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /label="asiMB gene" downshifts complement(930419) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(930673..931749) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" /label="asiMA CDS" gene complement(930673..931749) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /label="asiMA gene" CDS complement(931739..932230) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" /label="sigM CDS" gene complement(931739..932230) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /label="sigM gene" S_feature complement(932231..932333) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(932322..932341) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(932333) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(932355..932358) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 932371..932377 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 932388 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 932392..932410 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(932421) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS 932427..933422 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" /label="akrN CDS" gene 932427..933422 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /label="akrN gene" downshifts 933401 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 933484..933487 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 933502..933521 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 933507 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="upshifts" CDS 933557..934156 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" /label="plsC CDS" gene 933557..934156 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /label="plsC gene" downshifts 934171 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 934216..936170 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(934225..935559) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" /label="yhdP CDS" gene complement(934225..935559) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /label="yhdP gene" downshifts complement(934244) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" CDS complement(935620..936051) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" /label="cueR CDS" gene complement(935620..936051) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /label="cueR gene" promotor_-10 complement(936063..936082) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(936073) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(936097..936103) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(936099..936199) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 936134..936141 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(936139) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 936155..936174 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 936172 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="upshifts" CDS 936208..937389 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" /label="yhdR CDS" gene 936208..937389 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /label="yhdR gene" downshifts 937374 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" /label="downshifts" S_feature 937419..937557 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 937553..937572 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 937559..937715 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 937559 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="upshifts" CDS 937716..939101 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" /label="yhdT CDS" gene 937716..939101 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /label="yhdT gene" downshifts 938991 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 939077 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(939115..939471) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" /label="crcBA CDS" gene complement(939115..939471) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /label="crcBA gene" CDS complement(939468..939863) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" /label="crcBB CDS" gene complement(939468..939863) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /label="crcBB gene" CDS complement(939850..940581) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" /label="yhdW CDS" gene complement(939850..940581) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /label="yhdW gene" misc_feature complement(940606..940625) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(940627) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 940674..940682 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 940691 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 940696..940711 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 940705..940778 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 940765..940766 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 940780 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 940782..940801 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 940815..940922 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" /label="yhdX CDS" gene 940815..940922 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /label="yhdX gene" S_feature 940923..940976 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 940947 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 941027..941046 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 941033 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 941071..942186 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" /label="mscY CDS" gene 941071..942186 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /label="mscY gene" downshifts 942166 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" /label="downshifts" misc_feature 942223..942242 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 942223 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 942256..942999 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" /label="srtN CDS" gene 942256..942999 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /label="srtN gene" downshifts 942971 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(943023..943871) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" /label="yheN CDS" gene complement(943023..943871) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /label="yheN gene" downshifts complement(943047) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 943867..943872 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(943872..943971) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 943888..943906 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 943890 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="upshifts" S_feature 943895..944090 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(943960..943979) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(943974) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(943994..943997) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 944089..944108 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 944092..944155 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 944092 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="upshifts" CDS 944156..945004 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" /label="dat CDS" gene 944156..945004 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /label="dat gene" downshifts 944995 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(945047..946408) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" /label="nhaC CDS" gene complement(945047..946408) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /label="nhaC gene" downshifts complement(945071) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(946409..946479) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(946452..946471) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(946479) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(946535..947035) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" /label="nhaX CDS" gene complement(946535..947035) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /label="nhaX gene" downshifts complement(946567) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(947057..947075) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(947077) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(947090..947096) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 947114..947121 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 947129..947198 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 947130 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 947136..947155 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 947199..947360 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" /label="bmrB CDS" gene 947199..947360 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /label="bmrB gene" downshifts 947290 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" /label="downshifts" S_feature 947361..947479 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 947480..949237 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" /label="bmrC CDS" gene 947480..949237 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /label="bmrC gene" CDS 949234..951255 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" /label="bmrD CDS" gene 949234..951255 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /label="bmrD gene" downshifts 951243 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(951304..951924) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" /label="yheG CDS" gene complement(951304..951924) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /label="yheG gene" downshifts complement(951319) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 951909..952009 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(951938..951957) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(951953) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="upshifts" CDS complement(951963..952088) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" /label="yheF CDS" gene complement(951963..952088) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /label="yheF gene" upshifts 951969 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(951972..951975) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(952102..952121) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(952111) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(952135..952144) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 952167 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(952193..952396) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" /label="sspB CDS" gene complement(952193..952396) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /label="sspB gene" downshifts complement(952198) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(952397..952507) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 952437..952537 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 952497 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(952513) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(952517..952528) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(952543..952549) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(952605..952823) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" /label="yheE CDS" gene complement(952605..952823) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /label="yheE gene" downshifts complement(952639) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(952864..952883) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(952881) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(952897..952904) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(952973..954334) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" /label="spaD CDS" gene complement(952973..954334) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /label="spaD gene" downshifts complement(952991) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(953035) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(954324..955415) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" /label="spaC CDS" gene complement(954324..955415) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /label="spaC gene" promotor_-10 complement(954739..954753) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(954751) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(954767..954775) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(955416..955521) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(955505..955523) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(955525) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(955539..955544) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 955587..955594 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 955609..955628 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 955620 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="upshifts" CDS 955682..956815 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" /label="yheB CDS" gene 955682..956815 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /label="yheB gene" S_feature 956816..956907 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 956908..957261 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" /label="yheA CDS" gene 956908..957261 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /label="yheA gene" downshifts 957249 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(957305..958378) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" /label="yhaZ CDS" gene complement(957305..958378) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /label="yhaZ gene" downshifts complement(957412) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(958400..958419) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(958412) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(958433..958440) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 958515..958522 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 958535 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 958537..958556 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 958546..958699 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 958656 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 958701..958784 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 958741 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" /label="downshifts" promotor_-35 958797..958802 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 958818..958836 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 958827 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 958864..959730 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" /label="yhaX CDS" gene 958864..959730 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /label="yhaX gene" downshifts 959712 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 959775..959778 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 959793..959812 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 959801 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 959842..961347 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" /label="hemZ CDS" gene 959842..961347 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /label="hemZ gene" downshifts 961317 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(961365..962582) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" /label="khtU CDS" gene complement(961365..962582) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /label="khtU gene" downshifts complement(961371) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(962589..963086) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" /label="khtT CDS" gene complement(962589..963086) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /label="khtT gene" CDS complement(963150..963488) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" /label="khtS CDS" gene complement(963150..963488) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /label="khtS gene" promotor_-10 complement(963500..963519) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(963524) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(963533..963540) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 963560..963567 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 963582..963601 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 963592 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="upshifts" CDS 963653..964420 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" /label="yhaR CDS" gene 963653..964420 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /label="yhaR gene" downshifts 964421 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(964441..964626) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" /label="yhzD CDS" gene complement(964441..964626) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /label="yhzD gene" promotor_-10 complement(964662..964680) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(964673) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(964691..964699) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 964700..964703 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 964718..964737 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 964728 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="upshifts" CDS 964753..965649 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" /label="yhaQ CDS" gene 964753..965649 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /label="yhaQ gene" CDS 965642..966901 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" /label="yhaP CDS" gene 965642..966901 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /label="yhaP gene" downshifts 966885 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 966949..966956 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 966968..966987 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 966973 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 967008..968234 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" /label="yhaO CDS" gene 967008..968234 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /label="yhaO gene" downshifts complement(967709) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" /label="downshifts" CDS 968239..971130 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" /label="sbcE CDS" gene 968239..971130 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /label="sbcE gene" promotor_-35 969520..969525 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 969541..969559 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 969547 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 971138..971143 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 971158..971177 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 971173 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 971204..972148 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" /label="yhaM CDS" gene 971204..972148 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /label="yhaM gene" downshifts 972126 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 972207..972212 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 972228..972246 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 972231 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="upshifts" CDS 972273..972485 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" /label="yhaL CDS" gene 972273..972485 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /label="yhaL gene" downshifts 972478 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" /label="downshifts" downshifts complement(972516) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(972526..973404) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" /label="prsA CDS" gene complement(972526..973404) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /label="prsA gene" downshifts complement(972714) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(973442..973461) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(973466) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(973475..973482) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 973502..973511 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 973523 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 973524..973543 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(973560..973574) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(973561) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 973564..973650 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" /label="sscA CDS" gene 973564..973650 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /label="sscA gene" promotor_-35 complement(973583..973587) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 973651..973902 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 973775..973861 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" /label="sscB CDS" gene 973775..973861 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /label="sscB gene" downshifts 973859 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" S_feature complement(973871..974133) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 973904..974387 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(973914) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(974126..974145) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974133) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(974135..974203) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(974159..974164) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(974204..974722) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" /label="yhaJ CDS" gene complement(974204..974722) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /label="yhaJ gene" promotor_-35 974509..974517 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 974529..974547 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 974542 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(974753..974772) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(974771) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(974788..974794) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 974871..974874 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 974889..974908 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 974894 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="upshifts" CDS 974930..975271 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" /label="yhaI CDS" gene 974930..975271 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /label="yhaI gene" S_feature complement(975125..975267) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(975168) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(975268..975879) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" /label="scoC CDS" gene complement(975268..975879) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /label="scoC gene" S_feature 975272..976037 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(975344) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" promotor_-35 975875..975879 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 975887..975900 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 975899 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(975904..975923) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(975927) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="upshifts" promotor_-35 complement(975938..975941) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 975994 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(976057..976413) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" /label="yhaH CDS" gene complement(976057..976413) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /label="yhaH gene" downshifts complement(976061) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 976490..976495 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(976496..976515) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(976510) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 976511..976529 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 976511 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(976512..976775) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 976543..976734 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" /label="yhzF CDS" gene 976543..976734 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /label="yhzF gene" S_feature 976735..978170 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(976808..977326) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" /label="trpP CDS" gene complement(976808..977326) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /label="trpP gene" downshifts complement(976820) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" /label="downshifts" S_feature complement(977327..977414) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(977406..977425) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(977414) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(977439..977446) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(977451..978530) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" /label="serC CDS" gene complement(977451..978530) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /label="serC gene" misc_feature complement(978569..978588) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(978580) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(978582..978663) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(978677..979114) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" /label="hinT CDS" gene complement(978677..979114) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /label="hinT gene" downshifts complement(978708) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(979147..979166) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(979161) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" downshifts 979164 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(979180..979187) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(979186..979482) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(979229) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(979480..979491) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(979486) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(979506..979512) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 979542..979549 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 979563..979582 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 979572 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="upshifts" CDS 979602..980345 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" /label="ecsA CDS" gene 979602..980345 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /label="ecsA gene" CDS 980338..981564 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" /label="ecsB CDS" gene 980338..981564 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /label="ecsB gene" promotor_-10 complement(980897..980915) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(980912) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(980931..980936) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 981584..982294 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" /label="ecsC CDS" gene 981584..982294 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /label="ecsC gene" downshifts 982258 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(982312..983502) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" /label="sndC CDS" gene complement(982312..983502) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /label="sndC gene" downshifts complement(982322) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(982387) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(983526..983545) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(983547) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(983559..983564) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(983575..984966) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" /label="yhfA CDS" gene complement(983575..984966) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /label="yhfA gene" promotor_-10 complement(984977..984996) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(984982) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(985009..985018) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(985032..985346) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" /label="yhgB CDS" gene complement(985032..985346) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /label="yhgB gene" CDS complement(985391..985891) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" /label="hmoB CDS" gene complement(985391..985891) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /label="hmoB gene" downshifts complement(985418) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(985904..985923) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 985906..985910 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(985925) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 985926..985945 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 985927 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(985940..985941) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 985958..985964 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 985979..985990 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 985984 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="upshifts" CDS 986013..988157 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" /label="pbpF CDS" gene 986013..988157 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /label="pbpF gene" promotor_-10 complement(986057..986068) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(986060) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(986082..986088) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 988194..988200 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 988214..988233 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 988224 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" CDS 988279..989340 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" /label="hemE CDS" gene 988279..989340 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /label="hemE gene" CDS 989412..990344 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" /label="hemH CDS" gene 989412..990344 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /label="hemH gene" CDS 990359..991771 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" /label="hemY CDS" gene 990359..991771 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /label="hemY gene" downshifts 990362 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 991748 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 991832..991839 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 991853..991872 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 991858 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" CDS 991917..992492 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" /label="yhgD CDS" gene 991917..992492 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /label="yhgD gene" promotor_-35 992236..992239 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 992254 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 992256..992275 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 992493..992562 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 992563..994890 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" /label="yhgE CDS" gene 992563..994890 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /label="yhgE gene" downshifts 994872 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(994932..995909) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" /label="fabHB CDS" gene complement(994932..995909) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /label="fabHB gene" downshifts complement(994945) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(995923..995942) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(995941) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(995956..995962) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 995968..995976 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 995987..996005 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 995994 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 996036..996812 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" /label="yhfC CDS" gene 996036..996812 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /label="yhfC gene" S_feature complement(996528..997149) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 996813..997184 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(997127..997146) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(997148) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(997160..997169) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 997162..997169 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 997184..997203 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 997186 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 997225..998265 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" /label="yhfE CDS" gene 997225..998265 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /label="yhfE gene" CDS 998278..998685 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" /label="yhfF CDS" gene 998278..998685 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /label="yhfF gene" downshifts 998656 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(998722..1000011) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" /label="gltT CDS" gene complement(998722..1000011) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /label="gltT gene" downshifts complement(998752) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(1000012..1000112) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(1000111..1000130) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1000112) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1000114..1000250) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(1000145..1000151) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1000282..1000422) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" /label="yhfH CDS" gene complement(1000282..1000422) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /label="yhfH gene" downshifts complement(1000295) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1000441..1000460) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1000460) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1000473..1000480) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1000504..1000510 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1000524..1000543 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1000527 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="upshifts" CDS 1000574..1001308 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" /label="yhfI CDS" gene 1000574..1001308 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /label="yhfI gene" CDS 1001321..1002316 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" /label="lplJ CDS" gene 1001321..1002316 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /label="lplJ gene" CDS 1002381..1003025 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" /label="yhfK CDS" gene 1002381..1003025 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /label="yhfK gene" downshifts 1003013 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1003053..1003056 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1003071..1003090 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1003078 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="upshifts" CDS 1003142..1004683 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" /label="lcfB CDS" gene 1003142..1004683 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /label="lcfB gene" downshifts 1004663 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1004722..1005117) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" /label="yhfM CDS" gene complement(1004722..1005117) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /label="yhfM gene" downshifts complement(1004739) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1005137..1005148) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1005141) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1005163..1005169) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1005202..1005205 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1005213 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1005220..1005239 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1005266..1006546 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" /label="yhfN CDS" gene 1005266..1006546 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /label="yhfN gene" promotor_-10 complement(1005693..1005712) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1005707) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1005728..1005733) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1006533 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(1006583) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1006585..1007730) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" /label="aprE CDS" gene complement(1006585..1007730) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /label="aprE gene" S_feature complement(1007731..1007797) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1007786..1007805) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1007803) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1007821..1007825) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1008110..1008117 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1008132..1008151 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1008134 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="upshifts" CDS 1008165..1008614 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" /label="yhfO CDS" gene 1008165..1008614 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /label="yhfO gene" promotor_-35 1008630..1008637 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1008652..1008671 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1008659 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1008686..1009678 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" /label="yhfP CDS" gene 1008686..1009678 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /label="yhfP gene" downshifts 1009679 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" S_feature 1009724..1009834 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1009812..1009819 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1009835..1009854 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1009836 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1009895..1010866 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" /label="yhfQ CDS" gene 1009895..1010866 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /label="yhfQ gene" downshifts 1010845 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1010898..1011479) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" /label="phoE CDS" gene complement(1010898..1011479) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /label="phoE gene" downshifts complement(1010921) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1011503..1011522) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1011515) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1011538..1011541) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1011550..1012644) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" /label="yhfS CDS" gene complement(1011550..1012644) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /label="yhfS gene" CDS complement(1012641..1014080) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" /label="yhfT CDS" gene complement(1012641..1014080) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /label="yhfT gene" CDS complement(1014087..1014647) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" /label="bioY CDS" gene complement(1014087..1014647) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /label="bioY gene" misc_feature complement(1014097..1014116) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1014111) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1014672..1014691) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1014686) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1014706..1014713) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1014782..1016080) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" /label="hemAT CDS" gene complement(1014782..1016080) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /label="hemAT gene" downshifts complement(1014793) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1016134..1016152) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1016137) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1016166..1016172) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1016219..1017748) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" /label="yhfW CDS" gene complement(1016219..1017748) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /label="yhfW gene" promotor_-10 complement(1017775..1017793) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1017785) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1017804..1017809 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1017808..1017813) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1017821 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1017825..1017843 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1017860..1018717 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" /label="yhxC CDS" gene 1017860..1018717 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /label="yhxC gene" downshifts 1018699 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1018745..1018978) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" /label="yhzC CDS" gene complement(1018745..1018978) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /label="yhzC gene" downshifts complement(1018778) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1018995..1019014) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1018998..1018999 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1018998 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1019002..1019017 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1019017) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1019019..1019874) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1019029..1019036) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1019201..1019208 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1019220..1019239 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1019226 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="upshifts" CDS 1019271..1019849 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 1019271..1019849 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" S_feature 1019850..1019995 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1019896..1020795) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" /label="yhxD CDS" gene complement(1019896..1020795) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /label="yhxD gene" downshifts complement(1019919) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1019982..1019985 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1019997 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1020003..1020007 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1020041 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1020086..1020952 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1020822..1020840) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1020839) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1020855..1020861) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1020929..1020936 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1020951..1020970 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1020954 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1021012..1021281 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" /label="yhjA CDS" gene 1021012..1021281 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /label="yhjA gene" downshifts 1021273 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1021321) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1021324..1022793) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" /label="yhjB CDS" gene complement(1021324..1022793) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /label="yhjB gene" CDS complement(1022790..1022990) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" /label="yhjC CDS" gene complement(1022790..1022990) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /label="yhjC gene" S_feature complement(1022991..1023109) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1023092..1023111) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1023109) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1023124..1023131) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1023197) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1023198..1023560) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" /label="yhjD CDS" gene complement(1023198..1023560) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /label="yhjD gene" promotor_-35 1023398..1023403 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1023419..1023437 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1023420 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1023429..1023668 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1023590..1023609) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1023608) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1023624..1023631) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1023650..1023657 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1023670 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1023671..1023690 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1023712..1024335 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" /label="yhjE CDS" gene 1023712..1024335 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /label="yhjE gene" CDS 1024337..1024843 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" /label="sipV CDS" gene 1024337..1024843 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /label="sipV gene" downshifts 1024836 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1024894..1024901 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1024915..1024934 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1024924..1025023 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1024924 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="upshifts" CDS 1025024..1026523 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" /label="yhjG CDS" gene 1025024..1026523 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /label="yhjG gene" promotor_-35 1026531..1026538 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1026550 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1026552..1026571 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1026600..1027127 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" /label="yhjH CDS" gene 1026600..1027127 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /label="yhjH gene" downshifts 1027089 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" /label="downshifts" S_feature complement(1027141..>1027161) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" SCAR join(1027161,1027177) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" N_region 1027162..1027176 /note="inserted sequence possibly derived from two restrictions with NotI and SacI" /created_by="User" /modified_by="User" /label="IIG_Bs27_001" S_feature <1027177..1027463 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(<1027177..1027298) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1027183) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1027299..1028453) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" /label="yhjN CDS" gene complement(1027299..1028453) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /label="yhjN gene" S_feature complement(1028454..1028525) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1028508..1028527) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1028524) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1028541..1028546) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1028560..1029765) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" /label="yhjO CDS" gene complement(1028560..1029765) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /label="yhjO gene" misc_feature 1029786..1029805 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1029791 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1029879..1031606 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" /label="yhjP CDS" gene 1029879..1031606 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /label="yhjP gene" promotor_-35 1031192..1031199 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1031214..1031233 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1031221 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1031636..1031962) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" /label="yhjQ CDS" gene complement(1031636..1031962) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /label="yhjQ gene" CDS complement(1032080..1032517) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" /label="yhjR CDS" gene complement(1032080..1032517) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /label="yhjR gene" downshifts complement(1032089) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1032548..1032567) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1032568) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1032580..1032589) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1032637..1032644 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1032658..1032677 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1032670 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="upshifts" CDS 1032701..1036201 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" /label="addB CDS" gene 1032701..1036201 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /label="addB gene" CDS 1036188..1039886 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" /label="addA CDS" gene 1036188..1039886 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /label="addA gene" S_feature 1039887..1039957 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1039958..1041133 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " /label="sbcD CDS" gene 1039958..1041133 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /label="sbcD gene" CDS 1041130..1044522 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" /label="sbcC CDS" gene 1041130..1044522 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /label="sbcC gene" promotor_-35 1043777..1043783 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1043798..1043809 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1043805 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1043874..1044847) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1044536..1044838 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" /label="hlpB CDS" gene 1044536..1044838 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /label="hlpB gene" downshifts 1044818 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" /label="downshifts" downshifts complement(1044892) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" /label="downshifts" SCAR 1044896..1044897 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27_007" downshifts 1044916 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1044955..1045542) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" /label="yisN CDS" gene complement(1044955..1045542) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /label="yisN gene" promotor_-10 complement(1045557..1045576) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1045576) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1045592..1045594) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1045597..1045603 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1045615 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1045618..1045636 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1045621..1045687 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1045688..1047532 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" /label="asnO CDS" gene 1045688..1047532 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /label="asnO gene" S_feature 1047533..1047600 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1047557 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1047662..1048141) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " /label="yizA CDS" gene complement(1047662..1048141) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /label="yizA gene" upshifts complement(1048161) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1048165..1048183) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1048194..1048202) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1048333..1048337 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1048350 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1048352..1048371 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1048373..1049197 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" /label="farP CDS" gene 1048373..1049197 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /label="farP gene" promotor_-35 1048585..1048591 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1048606..1048624 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1048613 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1049207..1050657 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1049227..1050594) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" /label="yisQ CDS" gene complement(1049227..1050594) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /label="yisQ gene" promotor_-35 1050626..1050633 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1050647..1050666 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1050659 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="upshifts" CDS 1050718..1051581 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" /label="yisR CDS" gene 1050718..1051581 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /label="yisR gene" CDS 1051599..1052612 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" /label="iolQ CDS" gene 1051599..1052612 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /label="iolQ gene" downshifts 1052595 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-35 1052664..1052671 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1052686..1052705 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1052705..1052820 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1052705 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="upshifts" CDS 1052821..1053849 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" /label="iolX CDS" gene 1052821..1053849 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /label="iolX gene" downshifts 1053871 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1053900..1054409) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" /label="yisT CDS" gene complement(1053900..1054409) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /label="yisT gene" downshifts complement(1053919) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1054422..1054440) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1054438) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1054452..1054460) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1054459..1055121) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" /label="yisU CDS" gene complement(1054459..1055121) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /label="yisU gene" promotor_-35 1055140..1055146 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1055160..1055179 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1055169 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="upshifts" CDS 1055188..1056642 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" /label="yisV CDS" gene 1055188..1056642 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /label="yisV gene" S_feature complement(1056497..1056649) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1056532) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1056650..1057288) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" /label="yisX CDS" gene complement(1056650..1057288) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /label="yisX gene" S_feature complement(1057289..1057423) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1057337..1057342 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1057358..1057376 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1057359 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="upshifts" S_feature 1057369..1057493 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1057409..1057428) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1057423) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1057443..1057450) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1057494..1058300 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" /label="yisY CDS" gene 1057494..1058300 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /label="yisY gene" downshifts 1058293 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1058328..1058927) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" /label="yisZ CDS" gene complement(1058328..1058927) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /label="yisZ gene" downshifts complement(1058347) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1058924..1060093) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" /label="yitA CDS" gene complement(1058924..1060093) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /label="yitA gene" S_feature complement(1060094..1060205) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1060206..1060916) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" /label="yitB CDS" gene complement(1060206..1060916) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /label="yitB gene" promotor_-10 complement(1060960..1060979) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1060982) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1060992..1061001) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1061031..1061040 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1061054..1061073 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1061065 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="upshifts" CDS 1061101..1061787 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" /label="slpH CDS" gene 1061101..1061787 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /label="slpH gene" CDS 1061784..1062542 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" /label="slpS CDS" gene 1061784..1062542 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /label="slpS gene" downshifts 1062539 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1062587..1063216) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" /label="yitE CDS" gene complement(1062587..1063216) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /label="yitE gene" promotor_-10 complement(1063250..1063268) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1063267) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1063283..1063288) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1063312..1064427) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" /label="yitF CDS" gene complement(1063312..1064427) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /label="yitF gene" downshifts complement(1063341) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1064436..1065704) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" /label="yitG CDS" gene complement(1064436..1065704) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /label="yitG gene" promotor_-10 complement(1065730..1065741) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1065739) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1065755..1065761) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1065816..1066664) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" /label="yitH CDS" gene complement(1065816..1066664) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /label="yitH gene" downshifts complement(1065827) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1066669..1067118) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" /label="yitI CDS" gene complement(1066669..1067118) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /label="yitI gene" promotor_-10 complement(1067139..1067158) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1067153) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1067174..1067175) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1067208..1069046) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" /label="samT CDS" gene complement(1067208..1069046) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /label="samT gene" downshifts complement(1067235) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts complement(1069128) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1069136..1069253) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswK RNA" gene complement(1069136..1069253) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /label="mswK gene" promotor_-10 complement(1069305..1069324) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1069319) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1069339..1069346) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1069360..1069851) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" /label="yitK CDS" gene complement(1069360..1069851) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /label="yitK gene" promotor_-35 1069869..1069872 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1069875..1069894) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1069887..1069906 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1069888 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1069893) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1069909..1069916) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1069950..1070846 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" /label="yitL CDS" gene 1069950..1070846 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /label="yitL gene" downshifts 1070833 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1070909) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 1070921..1070922 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_016" S_feature <1070922..1070975 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" promotor_-10 complement(<1070922..1070936) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1070940) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1070954..1070959 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1070974..1070992 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1070977 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" CDS 1071014..1071856 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" /label="yitT CDS" gene 1071014..1071856 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /label="yitT gene" promotor_-35 1071509..1071517 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1071528..1071546 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1071528 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="upshifts" S_feature 1071857..1071970 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1071971..1072330 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" /label="ipi CDS" gene 1071971..1072330 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /label="ipi gene" downshifts 1072319 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1072361..1072558) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" /label="yizC CDS" gene complement(1072361..1072558) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /label="yizC gene" downshifts complement(1072374) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1072559..1072755) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1072755) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1072757..1072768) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1072783..1072789) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1072815..1073627) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" /label="ribZC CDS" gene complement(1072815..1073627) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /label="ribZC gene" promotor_-10 complement(1073665..1073684) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1073685..1073692 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1073685) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1073698..1073705) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1073704..1073723 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1073706 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1073748..1074515 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" /label="yitV CDS" gene 1073748..1074515 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /label="yitV gene" promotor_-35 1074524..1074530 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1074544 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1074545..1074564 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1074579..1074887 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" /label="yitW CDS" gene 1074579..1074887 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /label="yitW gene" downshifts 1074872 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" /label="downshifts" S_feature 1074917..1075182 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1075183..1076613 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" /label="yitY CDS" gene 1075183..1076613 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /label="yitY gene" CDS 1076658..1077152 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" /label="yitZ CDS" gene 1076658..1077152 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /label="yitZ gene" downshifts 1077116 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1077290..1077297 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1077296 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1077311..1077330 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1077359..1078396 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" /label="argC CDS" gene 1077359..1078396 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /label="argC gene" CDS 1078416..1079636 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" /label="argJ CDS" gene 1078416..1079636 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /label="argJ gene" CDS 1079651..1080427 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" /label="argB CDS" gene 1079651..1080427 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /label="argB gene" CDS 1080424..1081581 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" /label="argD CDS" gene 1080424..1081581 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /label="argD gene" CDS 1081652..1082707 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /modified_by="User" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGLSNGPGDPKAIQPY LGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMTSQ NHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEWIF DDYLKNVIPARREIAHA*" /label="Delta6_BSU_11230_SNPvariant" gene 1081652..1082707 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /modified_by="User" /label="Delta6_BSU_11230_SNPvariant" Polymorphism join(1082262,1082263) /Source="geneious" /ID="SNP_BsDelta6_1199938_1199943" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=6 /Amino_Acid_Change="GIV -> G" /CDS_Position=612 /Change="-AATTGT" /Codon_Change="GGA,ATT,GTG -> GGG" /Coverage="183 -> 185" /locus_tag="BSU_11230" /Protein_Effect="Deletion" /Reference_Frequency /Reference_Nucleotides="AATTGT" /Variant_Nucleotides /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="Delta6_BSU_11230_SNPvariant" / /modified_by="User" /label="Polymorphism_Delta6" misc_feature complement(1082541..1082560) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1082551) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1082700..1085792 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" /label="carB CDS" gene 1082700..1085792 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /label="carB gene" CDS 1085780..1086739 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" /label="argF CDS" gene 1085780..1086739 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /label="argF gene" downshifts 1086702 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" /label="downshifts" S_feature complement(1086742..1087016) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1086767..1086773 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1086775) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 1086788..1086799 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1086809 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="upshifts" CDS 1086825..1087004 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" /label="yjzC CDS" gene 1086825..1087004 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /label="yjzC gene" downshifts 1087014 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1087050..1087235) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" /label="yjzD CDS" gene complement(1087050..1087235) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /label="yjzD gene" downshifts complement(1087061) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1087264..1087283) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1087281) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1087294..1087301) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1087336..1087342 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1087354..1087373 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1087359 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1087416..1087425 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1087425 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1087438..1087457 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1087484..1088218 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" /label="yjaU CDS" gene 1087484..1088218 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /label="yjaU gene" S_feature complement(1087977..1088579) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1088199..1088204 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1088217 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" /label="downshifts" upshifts 1088217 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1088220..1088238 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1088300..1088857 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" /label="yjaV CDS" gene 1088300..1088857 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /label="yjaV gene" promotor_-10 complement(1088559..1088578) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1088579) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1088593..1088597) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1088864..1088871 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1088886..1088905 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1088898 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1088948..1089901 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" /label="med CDS" gene 1088948..1089901 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /label="med gene" promotor_-35 1089565..1089569 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1089585..1089604 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1089598 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1089916..1090107 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" /label="comZ CDS" gene 1089916..1090107 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /label="comZ gene" downshifts 1090086 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1090131..1090471 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1090137..1090376) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" /label="yjzB CDS" gene complement(1090137..1090376) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /label="yjzB gene" downshifts complement(1090153) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1090389..1090408) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1090410) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1090422..1090431) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1090437..1090444 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1090459..1090478 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1090473 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="upshifts" CDS 1090541..1091479 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" /label="fabHA CDS" gene 1090541..1091479 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /label="fabHA gene" promotor_-35 1090618..1090627 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1090636 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1090639..1090654 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1091502..1092743 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" /label="fabF CDS" gene 1091502..1092743 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /label="fabF gene" promotor_-10 complement(1091716..1091734) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1091724) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1091750..1091755) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1092594 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 1092727 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 1092768..1092777 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1092790..1092809 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1092792 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="upshifts" promotor_-35 1092804..1092812 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1092819..1093604 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" /label="yjaZ CDS" gene 1092819..1093604 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /label="yjaZ gene" promotor_-10 1092824..1092842 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1092836 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1093605..1093689 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1093621..1093639) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1093638) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1093654..1093659) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1093657..1093664 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1093679..1093698 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1093691..1093795 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1093691 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1093796..1094782 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" /label="appD CDS" gene 1093796..1094782 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /label="appD gene" CDS 1094779..1095768 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" /label="appF CDS" gene 1094779..1095768 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /label="appF gene" misc_feature 1095774..1095780 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1095779..1095855 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1095779 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1095856..1096347 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" /label="appAn CDS" gene 1095856..1096347 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo /label="appAn gene" CDS 1096320..1097486 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" /label="appAc CDS" gene 1096320..1097486 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo /label="appAc gene" downshifts 1097477 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" /label="downshifts" CDS 1097562..1098512 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" /label="appB CDS" gene 1097562..1098512 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /label="appB gene" CDS 1098529..1099440 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" /label="appC CDS" gene 1098529..1099440 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /label="appC gene" downshifts 1099454 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" S_feature 1099499..1099606 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1099579..1099584 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1099600..1099618 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1099608 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1099645..1100397 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" /label="yjbA CDS" gene 1099645..1100397 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /label="yjbA gene" downshifts 1100377 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1100432..1101424) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" /label="trpS CDS" gene complement(1100432..1101424) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /label="trpS gene" downshifts complement(1100453) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" misc_RNA complement(1101483..1101697) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboWA RNA" gene complement(1101483..1101697) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /label="tboWA gene" downshifts complement(1101531) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" misc_feature complement(1101716..1101735) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1101729) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1101984..1101991 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1102005..1102167 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1102006..1102025 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1102006 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1102168..1103805 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" /label="oppA CDS" gene 1102168..1103805 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /label="oppA gene" downshifts 1103699 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 1103806..1103912 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1103913..1104848 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" /label="oppB CDS" gene 1103913..1104848 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /label="oppB gene" promotor_-10 complement(1103956..1103975) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1103973) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1103991..1103997) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1104852..1105769 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" /label="oppC CDS" gene 1104852..1105769 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /label="oppC gene" CDS 1105774..1106850 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" /label="oppD CDS" gene 1105774..1106850 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /label="oppD gene" CDS 1106852..1107769 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" /label="oppF CDS" gene 1106852..1107769 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /label="oppF gene" downshifts 1107739 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 1107819..1107822 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1107835 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1107837..1107856 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1107876..1109093 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" /label="yjbB CDS" gene 1107876..1109093 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /label="yjbB gene" promotor_-35 1109146..1109155 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1109168..1109183 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1109177..1109256 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1109177 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="upshifts" CDS 1109257..1109835 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" /label="yjbC CDS" gene 1109257..1109835 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /label="yjbC gene" S_feature 1109836..1109950 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1109887..1109906) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1109891) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1109920..1109927) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1109953..1109966 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1109953 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="upshifts" CDS 1110016..1110411 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" /label="spxA CDS" gene 1110016..1110411 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /label="spxA gene" promotor_no_box complement(1110247..1110347) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1110287) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1110409 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1110454..1111243 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1110454..1111110) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" /label="yjbE CDS" gene complement(1110454..1111110) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /label="yjbE gene" promotor_-10 complement(1111140..1111158) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1111155) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1111173..1111178) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1111216..1111223 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1111237..1111256 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1111245..1111386 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1111245 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="upshifts" CDS 1111280..1111420 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" /label="conserved hypothetical protein CDS" gene 1111280..1111420 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /label="gene" CDS 1111387..1112043 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" /label="mecA CDS" gene 1111387..1112043 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /label="mecA gene" downshifts 1112033 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" /label="downshifts" CDS complement(1112038..1112160) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" /label="conserved hypothetical protein CDS" gene complement(1112038..1112160) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /label="gene" S_feature 1112078..1112167 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1112146..1112154 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1112165..1112183 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1112169..1112233 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1112169 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1112234..1113355 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" /label="coiA CDS" gene 1112234..1113355 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /label="coiA gene" promotor_-35 1113009..1113015 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1113027 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-10 1113030..1113048 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1113241..1113249 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1113261..1113279 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1113268 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-35 1113349..1113355 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1113370..1113381 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1113379 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1113402..1115414 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" /label="pepF CDS" gene 1113402..1115414 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /label="pepF gene" promotor_-35 1113477..1113484 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1113499..1113518 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1113511 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="upshifts" downshifts 1115361 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 1115415..1115716 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1115452..1115619) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" /label="yizD CDS" gene complement(1115452..1115619) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /label="yizD gene" downshifts complement(1115465) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1115639..1115657) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1115655) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1115673..1115678) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1115709..1115716 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1115718..1115843 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1115718 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1115724..1115862 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" /label="roxS RNA" gene 1115724..1115862 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /label="roxS gene" promotor_-10 1115731..1115750 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1115800 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" /label="downshifts" CDS complement(1115933..1116832) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" /label="spxH CDS" gene complement(1115933..1116832) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /label="spxH gene" downshifts complement(1115964) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1116168..1116173 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1116180 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1116189..1116207 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1116196..1118097 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1116829..1117227) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" /label="yjbI CDS" gene complement(1116829..1117227) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /label="yjbI gene" S_feature complement(1117228..1117407) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1117399..1117418) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1117407) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1117430..1117437) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1117482..1118027) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" /label="cwlQ CDS" gene complement(1117482..1118027) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /label="cwlQ gene" downshifts complement(1117506) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" S_feature complement(1118028..1118230) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1118231..1118803) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" /label="yjbK CDS" gene complement(1118231..1118803) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /label="yjbK gene" promotor_-10 complement(1118376..1118394) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1118385) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 complement(1118407..1118414) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1118832..1118851) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1118849) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 1118865..1118868 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1118866..1118873) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1118881 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1118884..1118903 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1118928..1119296 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" /label="yjbL CDS" gene 1118928..1119296 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /label="yjbL gene" CDS 1119325..1119960 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" /label="relP CDS" gene 1119325..1119960 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /label="relP gene" CDS 1119979..1120779 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" /label="ppnKA CDS" gene 1119979..1120779 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /label="ppnKA gene" CDS 1120842..1121693 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" /label="yjbO CDS" gene 1120842..1121693 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /label="yjbO gene" downshifts 1121652 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1121706..1122440) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" /label="prpE CDS" gene complement(1121706..1122440) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /label="prpE gene" downshifts complement(1121728) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" promotor_-35 1122562..1122566 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1122583..1122602 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1122597 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="upshifts" S_feature 1122598..1122674 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1122675..1124519 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" /label="kefQ CDS" gene 1122675..1124519 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /label="kefQ gene" misc_feature complement(1123002..1123021) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1123026) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1124521..1124528 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1124542..1124561 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1124548 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="upshifts" misc_RNA 1124581..1124689 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswA RNA" gene 1124581..1124689 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /label="tswA gene" downshifts 1124684 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS 1124768..1125478 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" /label="tenA CDS" gene 1124768..1125478 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /label="tenA gene" CDS 1125453..1126070 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" /label="tenI CDS" gene 1125453..1126070 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /label="tenI gene" CDS 1126054..1127163 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" /label="thiO CDS" gene 1126054..1127163 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /label="thiO gene" CDS 1127163..1127363 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" /label="thiS CDS" gene 1127163..1127363 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /label="thiS gene" CDS 1127360..1128130 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" /label="thiG CDS" gene 1127360..1128130 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /label="thiG gene" CDS 1128127..1129137 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" /label="thiF CDS" gene 1128127..1129137 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /label="thiF gene" CDS 1129156..1129971 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" /label="thiD CDS" gene 1129156..1129971 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /label="thiD gene" downshifts 1129945 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1130018..1130024 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1130037..1130056 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1130047 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="upshifts" CDS 1130107..1130883 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" /label="fabI CDS" gene 1130107..1130883 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /label="fabI gene" downshifts 1130872 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" /label="downshifts" SCAR 1130887..1130888 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_009" S_feature <1130888..1131948 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1130892..1133171) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" /label="yjcD CDS" gene complement(1130892..1133171) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /label="yjcD gene" downshifts complement(1130910) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1133046..1133220) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1133099..1133107 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1133118..1133136 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1133122..1133257 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1133122 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1133208..1133227) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1133219) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1133235..1133241 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1133243..1133247) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1133256..1133274 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1133259 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1133288..1133542 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" /label="yjzE CDS" gene 1133288..1133542 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /label="yjzE gene" downshifts 1133518 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1133608) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" /label="downshifts" CDS complement(1133615..1134037) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" /label="yjcF CDS" gene complement(1133615..1134037) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /label="yjcF gene" CDS complement(1134041..1134556) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" /label="yjcG CDS" gene complement(1134041..1134556) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /label="yjcG gene" CDS complement(1134593..1135315) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" /label="yjcH CDS" gene complement(1134593..1135315) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /label="yjcH gene" misc_feature complement(1135354..1135373) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1135375) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1135424..1135431 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1135446..1135465 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1135450 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1135483..1135603 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswA RNA" gene 1135483..1135603 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /label="mswA gene" downshifts 1135608 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" CDS 1135671..1136792 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" /label="metI CDS" gene 1135671..1136792 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /label="metI gene" CDS 1136785..1137957 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" /label="metC CDS" gene 1136785..1137957 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /label="metC gene" downshifts 1137940 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" misc_feature 1137974..1137992 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1137984 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="upshifts" S_feature 1137985..1139514 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1137990..1138535) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" /label="yjcK CDS" gene complement(1137990..1138535) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /label="yjcK gene" downshifts complement(1138011) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1138605..1139795) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" /label="yjcL CDS" gene complement(1138605..1139795) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /label="yjcL gene" promotor_-10 complement(1139821..1139840) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1139825) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1139855..1139862) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1139889..1139896 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1139900 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1139910..1139929 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1139968..1140040 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val2 tRNA" gene 1139968..1140040 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /label="trnSL-Val2 gene" promotor_-10 complement(1139982..1139999) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1139996) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1140020..1140026) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1140030 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" /label="downshifts" S_feature complement(1140055..1140790) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1140075..1141723 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1140084) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1140792..1140880) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1140835) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" /label="downshifts" CDS complement(1140881..1142110) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" /label="yjcM CDS" gene complement(1140881..1142110) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /label="yjcM gene" downshifts complement(1141003) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" /label="downshifts" downshifts 1141680 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1142111..1142196) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1142151..1142158 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1142173..1142192 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1142182..1142201) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1142186 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1142200) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1142214..1142220) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1142236..1142556 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" /label="yjcN CDS" gene 1142236..1142556 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /label="yjcN gene" downshifts 1142566 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" /label="downshifts" S_feature 1142611..1142708 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1142709..1142840 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " /label="yjzF CDS" gene 1142709..1142840 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /label="yjzF gene" CDS 1142856..1143029 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" /label="yjzG CDS" gene 1142856..1143029 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /label="yjzG gene" CDS 1143066..1143527 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" /label="yjcO CDS" gene 1143066..1143527 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /label="yjcO gene" promotor_-35 1143498..1143505 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1143520..1143539 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1143528..1143768 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1143528 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="upshifts" promotor_-35 1143741..1143748 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1143762..1143780 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1143770 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1143793..1144296 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" /label="yjcP CDS" gene 1143793..1144296 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /label="yjcP gene" CDS 1144308..1144592 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" /label="yjcQ CDS" gene 1144308..1144592 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /label="yjcQ gene" downshifts 1144562 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1144594) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1144605..1144608) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1144753..1145280 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" /label="yjcR CDS" gene 1144753..1145280 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /label="yjcR gene" promotor_-35 1145427..1145432 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1145445..1145464 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1145448 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="upshifts" CDS 1145454..1145771 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" /label="yjcS CDS" gene 1145454..1145771 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /label="yjcS gene" S_feature 1145772..1146007 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1146008..1146763 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" /label="yjdA CDS" gene 1146008..1146763 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /label="yjdA gene" S_feature 1146764..1146851 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1146808 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(1146851..1146911) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1146882) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1146912..1147259) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" /label="yjdB CDS" gene complement(1146912..1147259) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /label="yjdB gene" promotor_-10 complement(1147291..1147309) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1147304) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1147306..1147762) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1147320..1147328) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1147722..1147740 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1147734 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="upshifts" promotor_-10 complement(1147740..1147759) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1147762) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1147773..1147780) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1147810..1149756 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" /label="manR CDS" gene 1147810..1149756 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /label="manR gene" downshifts 1149732 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" SCAR 1149786..1149787 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs02" S_feature <1149787..1149885 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1149860..1149866 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1149881..1149900 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1149887..1149955 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1149887 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="upshifts" CDS 1149956..1150438 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" /label="yjdF CDS" gene 1149956..1150438 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /label="yjdF gene" downshifts 1150418 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1150484..1150990) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" /label="yjdG CDS" gene complement(1150484..1150990) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /label="yjdG gene" downshifts complement(1150508) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" /label="downshifts" misc_feature complement(1151015..1151034) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1151021) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1151023..1151208) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1151209..1151604) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" /label="yjdH CDS" gene complement(1151209..1151604) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /label="yjdH gene" promotor_-10 complement(1151627..1151645) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1151640) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1151642..1152342) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1151660..1151665) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1151748..1151755 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1151769..1151788 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1151780 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="upshifts" CDS 1151833..1152312 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " /label="trnE CDS" gene 1151833..1152312 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /label="trnE gene" downshifts 1152311 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1152352..1152546) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" /label="yjzH CDS" gene complement(1152352..1152546) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /label="yjzH gene" downshifts complement(1152387) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1152560..1152575) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1152576) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1152587..1152596) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1152712..1153041) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" /label="yjdJ CDS" gene complement(1152712..1153041) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /label="yjdJ gene" promotor_-10 complement(1153078..1153097) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1153091) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1153093..1153660) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1153112..1153117) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1153145..1153149 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1153165..1153184 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1153169..1153670 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1153169 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1153661..1154650) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" /label="ctaO CDS" gene complement(1153661..1154650) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /label="ctaO gene" promotor_-10 complement(1154651..1154670) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1154654) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="upshifts" promotor_-35 complement(1154684..1154689) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1154773..1155021) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" /label="cotT CDS" gene complement(1154773..1155021) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /label="cotT gene" downshifts complement(1154783) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1155017..1155021 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1155030..1155044 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1155039 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1155046..1155065) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1155055) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1155079..1155088) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1155136..1155143 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1155150..1155169) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1155157..1155176 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1155159) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="upshifts" upshifts 1155170 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1155171..1155274 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1155183..1155190) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1155275..1156678 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" /label="pdaC CDS" gene 1155275..1156678 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /label="pdaC gene" downshifts 1156667 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1156718..1157191) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" /label="yjfA CDS" gene complement(1156718..1157191) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /label="yjfA gene" downshifts complement(1156722) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1157213..1157231) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1157231) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1157246..1157251) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1157316..1157483) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" /label="yjfB CDS" gene complement(1157316..1157483) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /label="yjfB gene" downshifts complement(1157319) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1157495..1157513) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1157504) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1157526..1157533) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1157610..1158509 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" /label="yjfC CDS" gene 1157610..1158509 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /label="yjfC gene" CDS complement(1158518..1158916) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" /label="yjgA CDS" gene complement(1158518..1158916) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /label="yjgA gene" downshifts complement(1158548) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1158945..1158964) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1158964) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1158979..1158986) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1159017..1159592) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" /label="yjgB CDS" gene complement(1159017..1159592) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /label="yjgB gene" downshifts complement(1159032) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1159611..1159629) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1159626) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1159643..1159649) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1159667..1159673 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1159688..1159706 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1159689 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="upshifts" CDS 1159738..1162695 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" /label="yjgC CDS" gene 1159738..1162695 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /label="yjgC gene" CDS 1162688..1163248 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" /label="yjgD CDS" gene 1162688..1163248 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /label="yjgD gene" downshifts 1163241 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" /label="downshifts" S_feature 1163286..1163404 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1163382..1163385 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1163401..1163420 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1163406 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1163445..1164086 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" /label="yjhA CDS" gene 1163445..1164086 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /label="yjhA gene" downshifts complement(1163454) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" /label="downshifts" downshifts 1164059 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 1164165..1164791 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" /label="yjhB CDS" gene 1164165..1164791 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /label="yjhB gene" downshifts 1164793 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" /label="downshifts" downshifts complement(1164796) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(1164822..1165100) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" /label="yjiA CDS" gene complement(1164822..1165100) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /label="yjiA gene" downshifts complement(1164840) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1165129..1165140) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1165142..1165148) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1165148) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1165150..1165566) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1165318 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1165319..1165338 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1165336..1165490 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1165491..1166681 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" /label="cypE CDS" gene 1165491..1166681 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /label="cypE gene" promotor_-10 complement(1165564..1165583) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1165566) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1165597..1165606) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1166704..1167882 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" /label="ppuG CDS" gene 1166704..1167882 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /label="ppuG gene" CDS complement(1167923..1168111) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" /label="yjzI CDS" gene complement(1167923..1168111) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /label="yjzI gene" downshifts complement(1167939) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1168137..1168156) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1168140) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1168170..1168176) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1168198..1168205 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1168220..1168239 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1168231 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1168246..1168265) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1168250) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1168280..1168287) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1168285..1169097 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" /label="yjjA CDS" gene 1168285..1169097 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /label="yjjA gene" downshifts 1169076 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1169143..1169895) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" /label="yjkA CDS" gene complement(1169143..1169895) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /label="yjkA gene" downshifts complement(1169152) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" /label="downshifts" CDS complement(1169895..1170647) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" /label="yjkB CDS" gene complement(1169895..1170647) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /label="yjkB gene" CDS complement(1170767..1171741) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" /label="yjlA CDS" gene complement(1170767..1171741) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /label="yjlA gene" downshifts complement(1170802) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1171762..1171781) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1171788) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1171790..1174296) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1171796..1171803) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1171824..1171830 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1171845..1171863 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1171848 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1171873..1172370 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" /label="yjlB CDS" gene 1171873..1172370 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /label="yjlB gene" S_feature 1172371..1172484 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1172464..1172468 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1172484..1172503 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1172486..1172758 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1172486 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1172759..1173181 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" /label="yjlC CDS" gene 1172759..1173181 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /label="yjlC gene" CDS 1173221..1174399 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" /label="ndh CDS" gene 1173221..1174399 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /label="ndh gene" promotor_no_box 1174230..1174330 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1174288..1174306) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1174290 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1174296) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1174318..1174326) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1174398 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 1174507..1174514 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1174529..1174548 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1174554 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="upshifts" CDS 1174597..1176018 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" /label="uxaC CDS" gene 1174597..1176018 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /label="uxaC gene" CDS 1176086..1177465 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" /label="exuM CDS" gene 1176086..1177465 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /label="exuM gene" promotor_-10 complement(1176605..1176624) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1176610) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1176638..1176645) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1177490 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1177500..1177507 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1177502..1177569 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1177570..1178583 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" /label="yjmC CDS" gene 1177570..1178583 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /label="yjmC gene" CDS 1178589..1179608 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" /label="yjmD CDS" gene 1178589..1179608 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /label="yjmD gene" CDS 1179633..1180712 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" /label="uxuA CDS" gene 1179633..1180712 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /label="uxuA gene" CDS 1180709..1181545 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" /label="uxuB CDS" gene 1180709..1181545 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /label="uxuB gene" CDS 1181593..1182861 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" /label="exuT CDS" gene 1181593..1182861 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /label="exuT gene" promotor_-35 1182805..1182808 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1182824..1182828 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1182826 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1182894..1182913 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1182894 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" CDS 1182949..1183950 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " /label="exuR CDS" gene 1182949..1183950 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /label="exuR gene" promotor_no_box complement(1183632..1183732) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1183672) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1183926 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1184027..1185469 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" /label="uxaB CDS" gene 1184027..1185469 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /label="uxaB gene" CDS 1185466..1186959 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" /label="uxaA CDS" gene 1185466..1186959 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /label="uxaA gene" CDS complement(1186998..1187762) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /modified_by="User" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGGIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" /label="Delta6_BSU_12400_SNPvariant" gene complement(1186998..1187762) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /modified_by="User" /label="Delta6_BSU_12400_SNPvariant" downshifts complement(1187017) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" Polymorphism join(1187530,1187532) /Source="geneious" /ID="SNP_BsDelta6_1313384_1313384" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="S -> G" /CDS_Position=232 /Change="T -> C" /Codon_Change="AGT -> GGT" /Coverage=150 /locus_tag="BSU_12400" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=149 /comment="Delta6_BSU_12400_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" SCAR join(1187789,1187796) /created_by="User" /modified_by="User" /label="TF8A" N_region 1187790..1187795 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1187798..1188118 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1187798..1188118 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1188127 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" S_feature complement(1188136..1188339) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1188155..1188292) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" /label="spoIISC CDS" gene complement(1188155..1188292) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /label="spoIISC gene" downshifts complement(1188179) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1188378..1188548) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" /label="spoIISB CDS" gene complement(1188378..1188548) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /label="spoIISB gene" downshifts complement(1188384) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" /label="downshifts" CDS complement(1188548..1189294) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" /label="spoIISA CDS" gene complement(1188548..1189294) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /label="spoIISA gene" promotor_-10 complement(1189129..1189148) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1189146) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1189164..1189171) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1189320..1189338) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1189333) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1189354..1189359) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1189404..1190405) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " /label="pitB CDS" gene complement(1189404..1190405) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /label="pitB gene" downshifts complement(1189433) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1190418..1191035) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" /label="ykaA CDS" gene complement(1190418..1191035) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /label="ykaA gene" promotor_-10 complement(1191071..1191090) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1191073) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1191075..1191172) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1191106..1191110) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1191152..1191171) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1191172) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1191186..1191193) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1191217..1191236) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1191229) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1191311..1192627) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" /label="steT CDS" gene complement(1191311..1192627) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /label="steT gene" downshifts complement(1191326) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1192674..1192693) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1192690) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="upshifts" promotor_-35 complement(1192708..1192711) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1192910..1192917 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1192932..1192951 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1192944..1193015 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1192944 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="upshifts" CDS 1193016..1193966 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" /label="mhqA CDS" gene 1193016..1193966 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /label="mhqA gene" downshifts 1193954 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 1194067..1194213 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" /label="hypothetical protein CDS" gene 1194067..1194213 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /label="gene" CDS 1194221..1196371 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" /label="ykcB CDS" gene 1194221..1196371 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /label="ykcB gene" promotor_no_box 1195110..1195210 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1195170 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1195258 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1196383..1197354 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" /label="ykcC CDS" gene 1196383..1197354 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /label="ykcC gene" S_feature complement(1196711..1197352) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1197397) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" /label="downshifts" S_feature complement(1197422..1197788) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1197465) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1197768..1197783) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1197788) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1197795..1197804) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1197872..1199221) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " /label="htrA CDS" gene complement(1197872..1199221) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /label="htrA gene" downshifts complement(1197886) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1199261..1199268 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1199273..1199292) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1199281 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="upshifts" promotor_-10 1199283..1199302 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1199291) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1199293..1199375) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1199303..1199310) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1199332..1199338 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1199353..1199372 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1199356 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1199358..1199377) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1199375) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1199390..1200208 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" /label="proCC CDS" gene 1199390..1200208 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /label="proCC gene" promotor_-35 complement(1199393..1199396) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1200186 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1200265..1200272 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1200287..1200306 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1200291 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1200337..1201161 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" /label="dppA CDS" gene 1200337..1201161 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /label="dppA gene" CDS 1201178..1202104 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" /label="dppB CDS" gene 1201178..1202104 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /label="dppB gene" CDS 1202110..1203072 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" /label="dppC CDS" gene 1202110..1203072 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /label="dppC gene" promotor_-35 1202804..1202809 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1202825..1202843 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1202826 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1203077..1204084 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" /label="dppD CDS" gene 1203077..1204084 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /label="dppD gene" CDS 1204087..1205736 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" /label="dppE CDS" gene 1204087..1205736 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /label="dppE gene" downshifts 1205730 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" /label="downshifts" CDS 1205824..1206783 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" /label="ldcA CDS" gene 1205824..1206783 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /label="ldcA gene" CDS 1206780..1207880 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" /label="aeeB CDS" gene 1206780..1207880 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /label="aeeB gene" CDS 1207877..1208767 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" /label="eepC CDS" gene 1207877..1208767 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /label="eepC gene" CDS 1208780..1209769 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" /label="ykfD CDS" gene 1208780..1209769 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /label="ykfD gene" S_feature complement(1209063..1209790) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1209759 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" S_feature 1209804..1210972 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1209812..1210861) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" /label="pgl CDS" gene complement(1209812..1210861) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /label="pgl gene" downshifts complement(1209835) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1210888..1210907) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1210899) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1210922..1210929) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1210951..1211811) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" /label="ddaH CDS" gene complement(1210951..1211811) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /label="ddaH gene" promotor_-10 complement(1211836..1211854) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1211853) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1211870..1211876) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1211885..1211892 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1211906..1211925 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1211913 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="upshifts" CDS 1211971..1212489 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" /label="ykhA CDS" gene 1211971..1212489 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /label="ykhA gene" downshifts 1212480 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" /label="downshifts" promotor_-35 1212554..1212560 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1212572..1212678 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1212572 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="upshifts" promotor_-10 1212574..1212585 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1212653..1212656 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1212672..1212691 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1212680 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1212728..1213927 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" /label="hmpA CDS" gene 1212728..1213927 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /label="hmpA gene" downshifts 1213916 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1213961..1214332 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1214004..1214228) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" /label="ykzH CDS" gene complement(1214004..1214228) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /label="ykzH gene" promotor_-35 1214308..1214314 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1214328..1214339 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1214334 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1214373..1215104 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" /label="ykjA CDS" gene 1214373..1215104 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /label="ykjA gene" downshifts 1215082 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1215143..1215151 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1215162..1215180 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1215170 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1215196..1215723 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" /label="ykkA CDS" gene 1215196..1215723 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /label="ykkA gene" CDS 1215713..1216231 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" /label="ykkB CDS" gene 1215713..1216231 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /label="ykkB gene" promotor_-35 1216225..1216232 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1216246..1216265 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1216249 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="upshifts" misc_RNA 1216264..1216375 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" /label="gdwA RNA" gene 1216264..1216375 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /label="gdwA gene" downshifts 1216338 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" /label="downshifts" CDS 1216453..1216791 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" /label="gdnC CDS" gene 1216453..1216791 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /label="gdnC gene" CDS 1216791..1217108 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" /label="gdnD CDS" gene 1216791..1217108 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /label="gdnD gene" promotor_-35 1217108..1217111 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1217127..1217146 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1217139 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1217179..1218081 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" /label="purU CDS" gene 1217179..1218081 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /label="purU gene" downshifts 1218072 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" /label="downshifts" promotor_-35 1218128..1218134 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1218140 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1218148..1218167 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1218169..1218379 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" /label="pswB RNA" gene 1218169..1218379 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /label="pswB gene" downshifts 1218337 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1218432..1219529 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" /label="proB CDS" gene 1218432..1219529 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /label="proB gene" promotor_-35 1218619..1218621 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1218623..1218627 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1218623 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1219541..1220788 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" /label="proA CDS" gene 1219541..1220788 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /label="proA gene" downshifts 1220779 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1220850..1220857 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1220872..1220891 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1220881 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1220914..1221339 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" /label="ohrA CDS" gene 1220914..1221339 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /label="ohrA gene" downshifts 1221328 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1221370..1221813) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" /label="ohrR CDS" gene complement(1221370..1221813) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /label="ohrR gene" downshifts complement(1221404) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1221840..1221859) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1221846) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1221874..1221877) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1221895..1221901 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1221915..1221933 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1221921 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="upshifts" CDS 1221956..1222366 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" /label="ohrB CDS" gene 1221956..1222366 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /label="ohrB gene" downshifts 1222344 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" /label="downshifts" CDS 1222393..1222563 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" /label="ykzN CDS" gene 1222393..1222563 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /label="ykzN gene" S_feature 1222564..1223241 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1222613..1223083) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" /label="guaN CDS" gene complement(1222613..1223083) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /label="guaN gene" downshifts complement(1222637) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1223105..1223124) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1223121) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1223123..1223230) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1223140..1223143) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1223199 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1223256..1225544) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" /label="metE CDS" gene complement(1223256..1225544) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /label="metE gene" downshifts complement(1223275) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature complement(1225545..1225607) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1225567..1225667) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1225607) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1225672..1225827) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" /label="mswB RNA" gene complement(1225672..1225827) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /label="mswB gene" downshifts complement(1225673) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1225860..1225879) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1225872) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1225874..1225959) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1225895..1225902) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1225960..1226919) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" /label="ispA CDS" gene complement(1225960..1226919) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /label="ispA gene" S_feature complement(1226920..1226971) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1226964..1226983) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1226976) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1226997..1227003) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1227088..1227091 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1227104 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1227107..1227126 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1227142..1227975 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" /label="rsbRB CDS" gene 1227142..1227975 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /label="rsbRB gene" downshifts 1227951 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1228006..1228770) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" /label="thiX CDS" gene complement(1228006..1228770) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /label="thiX gene" downshifts complement(1228027) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1228745..1230388) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" /label="thiW CDS" gene complement(1228745..1230388) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /label="thiW gene" CDS complement(1230375..1230974) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" /label="thiV CDS" gene complement(1230375..1230974) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /label="thiV gene" CDS complement(1230976..1231578) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" /label="thiU CDS" gene complement(1230976..1231578) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /label="thiU gene" downshifts complement(1231656) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1231675..1231787) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswB RNA" gene complement(1231675..1231787) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /label="tswB gene" promotor_-35 1231788..1231791 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1231802..1231821) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1231807..1231826 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1231818 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1231823) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1231836..1231843) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1231889..1232575 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" /label="ykoG CDS" gene 1231889..1232575 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /label="ykoG gene" CDS 1232579..1233943 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" /label="ykoH CDS" gene 1232579..1233943 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /label="ykoH gene" CDS 1233940..1234620 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" /label="ykoI CDS" gene 1233940..1234620 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /label="ykoI gene" promotor_-35 1234649..1234654 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1234670..1234688 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1234673 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1234712..1235224 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" /label="ykoJ CDS" gene 1234712..1235224 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /label="ykoJ gene" downshifts 1235210 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 1235255..1235261 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1235275..1235286 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1235276 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1235307..1235444 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" /label="ykzD CDS" gene 1235307..1235444 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /label="ykzD gene" downshifts 1235417 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1235503..1235510 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1235524..1235543 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1235526..1235845 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1235526 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1235558..1235711 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="swmG RNA" gene 1235558..1235711 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /label="swmG gene" promotor_-35 1235823..1235832 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1235845..1235864 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1235847..1235948 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1235847 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" CDS 1235949..1237304 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" /label="mgtE CDS" gene 1235949..1237304 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /label="mgtE gene" downshifts 1237295 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1237347..1237679) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" /label="tnrA CDS" gene complement(1237347..1237679) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /label="tnrA gene" promotor_-10 complement(1237695..1237714) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1237705) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1237707..1238095) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1237730..1237735) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1237767..1237867 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1237827 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="upshifts" CDS 1237874..1238029 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" /label="ykzB CDS" gene 1237874..1238029 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /label="ykzB gene" promotor_-35 1238038..1238045 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1238052..1238069 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1238069 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1238080..1238099) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1238095) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1238113..1238119) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1238117..1238299 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" /label="ykoL CDS" gene 1238117..1238299 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /label="ykoL gene" downshifts 1238267 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1238324..1238332 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1238343..1238361 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1238349..1238431 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1238349 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" CDS 1238432..1238896 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" /label="ykoM CDS" gene 1238432..1238896 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /label="ykoM gene" downshifts 1238881 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" /label="downshifts" CDS complement(1238911..1240032) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" /label="ykoN CDS" gene complement(1238911..1240032) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /label="ykoN gene" promotor_-35 1239320..1239328 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1239342..1239361 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1239345..1240123 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1239345 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1240061..1240072) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1240081) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1240087..1240093) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1240124..1240675 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" /label="ykoP CDS" gene 1240124..1240675 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /label="ykoP gene" downshifts 1240643 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(1240703..1241515) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" /label="ykoQ CDS" gene complement(1240703..1241515) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /label="ykoQ gene" promotor_-10 complement(1241475..1241494) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1241489) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1241508..1241513) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1241616..1241622 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1241633..1241707 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1241633 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1241636..1241647 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1241708..1243402 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" /label="ykoS CDS" gene 1241708..1243402 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /label="ykoS gene" CDS 1243415..1244428 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" /label="ykoT CDS" gene 1243415..1244428 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /label="ykoT gene" downshifts 1244413 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(1244454..1246289) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" /label="ligD CDS" gene complement(1244454..1246289) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /label="ligD gene" downshifts complement(1244503) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1246293..1247228) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" /label="ligV CDS" gene complement(1246293..1247228) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /label="ligV gene" promotor_-10 complement(1247199..1247210) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1247209) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1247225..1247231) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1247265..1249667) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" /label="dgcW CDS" gene complement(1247265..1249667) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /label="dgcW gene" downshifts complement(1247297) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1249515..1249717) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1249706..1249724) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1249717) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1249738..1249745) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1249784..1249791 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1249805..1249824 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1249817 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="upshifts" CDS 1249848..1250513 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" /label="ykoX CDS" gene 1249848..1250513 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /label="ykoX gene" promotor_-10 complement(1250382..1250401) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1250399) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1250415..1250424) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1250508..1250515 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1250530..1250549 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1250543 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1250569..1250702 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="mnrW RNA" gene 1250569..1250702 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /label="mnrW gene" CDS 1250590..1251564 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" /label="ykoY CDS" gene 1250590..1251564 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /label="ykoY gene" downshifts 1250653 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" /label="downshifts" downshifts 1251552 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1251674..1251682 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1251696..1251704 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1251706 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="upshifts" S_feature 1251709..1251795 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1251768..1251775 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1251789..1251808 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1251797 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="upshifts" CDS 1251828..1252583 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" /label="sigI CDS" gene 1251828..1252583 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /label="sigI gene" CDS 1252580..1253725 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" /label="rsgI CDS" gene 1252580..1253725 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /label="rsgI gene" S_feature 1253726..1254885 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1253736..1253930) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" /label="sspD CDS" gene complement(1253736..1253930) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /label="sspD gene" downshifts complement(1253743) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1253973..1253984) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1253983) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1253999..1254005) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1254061..1254762) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" /label="htpK CDS" gene complement(1254061..1254762) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /label="htpK gene" downshifts complement(1254095) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1254763..1254843) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1254835..1254854) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1254843) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1254859..1254866 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1254868..1254875) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1254880..1254899 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1254887 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="upshifts" CDS 1254933..1255829 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" /label="htpX CDS" gene 1254933..1255829 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /label="htpX gene" downshifts 1255823 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1255934..1255938 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1255954..1255973 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1255958 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="upshifts" CDS 1256003..1257352 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " /label="ktrD CDS" gene 1256003..1257352 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /label="ktrD gene" downshifts 1257340 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1257401..1257407 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1257421..1257432 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1257429..1257496 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1257429 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1257497..1257652 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" /label="ykzP CDS" gene 1257497..1257652 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /label="ykzP gene" CDS 1257655..1257831 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" /label="ykzE CDS" gene 1257655..1257831 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /label="ykzE gene" promotor_no_box 1257721..1257821 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1257781 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1257827 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1257874..1258896) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" /label="ykrP CDS" gene complement(1257874..1258896) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /label="ykrP gene" downshifts complement(1257897) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1258941..1258960) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1258957) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1258972..1258978) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1259085..1259093 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1259101 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1259104..1259122 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1259149..1261365 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" /label="kinE CDS" gene 1259149..1261365 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /label="kinE gene" S_feature complement(1261140..1262080) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1261218..1261225 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1261240..1261259 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1261242 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="upshifts" CDS 1261362..1261859 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" /label="ogt CDS" gene 1261362..1261859 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /label="ogt gene" S_feature 1261860..1262099 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1261949..1262074 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" /label="hypothetical protein CDS" gene 1261949..1262074 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /label="gene" downshifts 1262067 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1262108..1263169) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" /label="mtnA CDS" gene complement(1262108..1263169) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /label="mtnA gene" downshifts complement(1262125) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(1263177..1264370) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" /label="mtnK CDS" gene complement(1263177..1264370) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /label="mtnK gene" downshifts 1263237 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts complement(1264457) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1264463..1264619) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" /label="mswC RNA" gene complement(1264463..1264619) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /label="mswC gene" promotor_-10 complement(1264654..1264673) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1264655) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1264689..1264696) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1264699..1264702 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1264703..1265482) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" /label="mtnU CDS" gene complement(1264703..1265482) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /label="mtnU gene" promotor_-10 1264718..1264737 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1264727 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1265175..1265182 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1265195..1265214 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1265210 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="upshifts" S_feature 1265217..1265534 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1265504..1265511 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1265512..1265531) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1265526..1265545 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1265526) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" upshifts 1265536 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1265547..1265554) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1265577..1266773 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" /label="mtnE CDS" gene 1265577..1266773 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /label="mtnE gene" promotor_-35 1266755..1266762 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1266777..1266796 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1266796 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1266812..1266912 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" /label="mswD RNA" gene 1266812..1266912 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /label="mswD gene" downshifts 1266911 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS 1266997..1268214 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" /label="mtnW CDS" gene 1266997..1268214 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /label="mtnW gene" CDS 1268211..1268918 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" /label="mtnX CDS" gene 1268211..1268918 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /label="mtnX gene" CDS 1268876..1269505 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" /label="mtnB CDS" gene 1268876..1269505 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /label="mtnB gene" CDS 1269520..1270056 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" /label="mtnD CDS" gene 1269520..1270056 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /label="mtnD gene" S_feature complement(1269903..1270096) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1270056 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1270097..1270417) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" /label="ykvA CDS" gene complement(1270097..1270417) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /label="ykvA gene" downshifts complement(1270155) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(1270418..1270507) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1270443..1270449 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1270464..1270482 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1270474 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" S_feature 1270475..1270559 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1270489..1270508) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1270506) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1270523..1270526) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1270533..1270540 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1270555..1270574 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1270561..1270619 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1270561 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1270617) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1270620..1270877 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" /label="spo0E CDS" gene 1270620..1270877 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /label="spo0E gene" downshifts 1270871 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS 1270963..1271394 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" /label="eag CDS" gene 1270963..1271394 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /label="eag gene" CDS complement(1271422..1272942) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /EC_number="2.7.13.3" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine kinase phosphorylating Spo0A" /protein_id="NP_389249.1" /db_xref="EnsemblGenomes-Gn:BSU13660" /db_xref="EnsemblGenomes-Tr:CAB13239" /db_xref="GOA:O31671" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4JGO" /db_xref="PDB:4JGP" /db_xref="PDB:4JGQ" /db_xref="PDB:4JGR" /db_xref="SubtiList:BG13309" /db_xref="UniProtKB/Swiss-Prot:O31671" /translation="MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIA AEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPR FSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFT ICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAE DQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQ TQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIE QEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTE QPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQE MLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS*" /label="kinD CDS" gene complement(1271422..1272942) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /label="kinD gene" downshifts complement(1271434) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1272143..1272149 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1272163..1272174 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1272169 /Source="Nicolas_upshifts" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1272950..1272969) /Source="Nicolas_upshift_promotors" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1272971) /Source="Nicolas_upshifts" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1273069..1273076 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1273091..1273110 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1273093 /Source="Nicolas_upshifts" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="upshifts" CDS 1273135..1273572 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17725564, 17962296, 18282125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17725564, 17962296, 18282125; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family)" /protein_id="NP_389250.1" /db_xref="EnsemblGenomes-Gn:BSU13670" /db_xref="EnsemblGenomes-Tr:CAB13240" /db_xref="GOA:O31672" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13310" /db_xref="UniProtKB/Swiss-Prot:O31672" /translation="MTEKSLKLFIVLSRAYRSINDHMNKHIHKHGLNPTEFAVLELLY HKGDQPLQQIGDKILLASGSITYVVDKLEQKELLIRKASPTDRRVTFAQITEKGIGLL NDIFPDHAAEIDEMISVLSEEEVEMCTEMLKRVGLNAKQFHNK*" /label="mhqR CDS" gene 1273135..1273572 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /label="mhqR gene" downshifts 1273555 /Source="Nicolas_upshifts" /id="D754" /incds=0 /nref=210 /ntot=257 /MaxReadThrough="1.20686" /MaxDrop="5.47215" /score="1.59181784" /energy="-8.9" /TU="U1110" /idTUdmin="U1110" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1273612..1274397) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein B; MotB component of the H+-coupled stator flagellum complex" /protein_id="NP_389251.1" /db_xref="EnsemblGenomes-Gn:BSU13680" /db_xref="EnsemblGenomes-Tr:CAB13241" /db_xref="GOA:P28612" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10689" /db_xref="UniProtKB/Swiss-Prot:P28612" /translation="MARKKKKKHEDEHVDESWLVPYADILTLLLALFIVLYASSSIDA AKFQMLSKSFNEVFTGGTGVLDYSSVTPPENESDGIDEVKKEKEEKEKNKKEKEKAAD QEELENVKSQVEKFIKDKKLEHQLETKMTSEGLLITIKDSIFFDSGKATIRKEDVPLA KEISNLLVINPPRNIIISGHTDNMPIKNSEFQSNWHLSVMRAVNFMGLLIENPKLDAK VFSAKGYGEYKPVASNKTAEGRSKNRRVEVLILPRGAAETNEK*" /label="motB CDS" gene complement(1273612..1274397) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /label="motB gene" downshifts complement(1273631) /Source="Nicolas_upshifts" /id="D755" /incds=0 /nref=224 /ntot=246 /MaxReadThrough="3.05351" /MaxDrop="6.69306" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(1274093) /Source="Nicolas_upshifts" /id="D756" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="8.03566" /MaxDrop="4.69358" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1274369..1275181) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein A; MotA component of the H+-coupled stator flagellum complex" /protein_id="NP_389252.1" /db_xref="EnsemblGenomes-Gn:BSU13690" /db_xref="EnsemblGenomes-Tr:CAB13242" /db_xref="GOA:P28611" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10688" /db_xref="UniProtKB/Swiss-Prot:P28611" /translation="MDKTSLIGIILAFVALSVGMVLKGVSFSALANPAAILIIIAGTI SAVVIAFPTKEIKKVPTLFRVLFKENKQLTIEELIPMFSEWAQLARREGLLALEASIE DVDDAFLKNGLSMAVDGQSAEFIRDIMTEEVEAMEDRHQAGAAIFTQAGTYAPTLGVL GAVIGLIAALSHMDNTDELGHAISAAFVATLLGIFTGYVLWHPFANKLKRKSKQEVKL REVMIEGVLSVLEGQAPKVIEQKLLMYLPAKDRLKFAEQGEAQNGEKKEEEA*" /label="motA CDS" gene complement(1274369..1275181) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /label="motA gene" promotor_-10 complement(1275212..1275230) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1275228) /Source="Nicolas_upshifts" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1275244..1275251) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1275319..1275541) /Source="Nicolas_S_feature" /locus_tag="new_1435383_1435605_c" /HighExp="Diami, dia15, dia5, Heat, Etha, LPhT, H2O2, C30, G135, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.93062599999999995" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S491" downshifts complement(1275351) /Source="Nicolas_upshifts" /id="D757" /incds=0 /nref=5 /ntot=12 /MaxReadThrough="0.48394" /MaxDrop="4.60081" /score="30.9355071" /energy="-15.4" /TU="NA" /idTUdmin="U1112" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1275564..1277663) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" /label="clpE CDS" gene complement(1275564..1277663) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /label="clpE gene" downshifts complement(1275586) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" /label="downshifts" S_feature complement(1277664..1277914) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1277874..1277974) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1277914) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1277950..1277955 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1277965 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1277971..1277989 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1278028..1279071 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" /label="ykvI CDS" gene 1278028..1279071 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /label="ykvI gene" S_feature 1279072..1279163 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1279140..1279144 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1279161..1279180 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1279165 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1279210..1279254 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" /label="qswA RNA" gene 1279210..1279254 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /label="qswA gene" downshifts 1279231 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1279276..1279383 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1279384..1280043 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" /label="queC CDS" gene 1279384..1280043 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /label="queC gene" CDS 1280036..1280485 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" /label="queD CDS" gene 1280036..1280485 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /label="queD gene" CDS 1280478..1281209 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" /label="queE CDS" gene 1280478..1281209 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /label="queE gene" CDS 1281227..1281724 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" /label="queF CDS" gene 1281227..1281724 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /label="queF gene" S_feature 1281725..1282001 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1281959 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1281969) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature complement(1282038..1282282) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1282079) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1282283..1282639) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" /label="ykvN CDS" gene complement(1282283..1282639) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /label="ykvN gene" misc_feature complement(1282670..1282689) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1282687) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1282724..1282742 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1282729 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="upshifts" CDS 1282808..1283554 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" /label="ykvO CDS" gene 1282808..1283554 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /label="ykvO gene" downshifts 1283609 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1283957..1283965 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1283979..1283998 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1283983 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="upshifts" CDS 1284035..1285234 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" /label="ykvP CDS" gene 1284035..1285234 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /label="ykvP gene" promotor_-35 1284117..1284123 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1284138..1284156 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1284144 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1285203..1285205 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1285225..1285243 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1285237 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1285250..1285477 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" /label="ykzQ CDS" gene 1285250..1285477 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /label="ykzQ gene" misc_feature complement(1285327..1285346) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1285335) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1285478..1285573 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1285574..1286272 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" /label="ykvQ CDS" gene 1285574..1286272 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo /label="ykvQ gene" S_feature complement(1286225..1287051) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1286253..1286504 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" /label="ykzR CDS" gene 1286253..1286504 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo /label="ykzR gene" misc_feature 1286754..1286769 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1286777..1286988 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1286777 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="upshifts" downshifts 1286953 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1287040..1287059) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1287062) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1287075..1287082) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1287127..1287134 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1287149..1287168 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1287151 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="upshifts" CDS 1287187..1287477 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" /label="ykvR CDS" gene 1287187..1287477 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /label="ykvR gene" S_feature complement(1287514..1287597) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1287557) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1287598..1287783) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" /label="ykvS CDS" gene complement(1287598..1287783) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /label="ykvS gene" promotor_-10 complement(1287816..1287835) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1287827) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1287829..1288173) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1287849..1287856) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1287882..1287887 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1287903..1287922 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1287910 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="upshifts" CDS 1287949..1288143 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" /label="ykzS CDS" gene 1287949..1288143 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /label="ykzS gene" downshifts 1288119 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1288164..1288182) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1288180) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1288199..1288204) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1288442..1289068 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" /label="ykvT CDS" gene 1288442..1289068 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /label="ykvT gene" downshifts 1288999 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1289125..1289130 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1289137 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1289146..1289164 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1289186..1290523 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" /label="ykvU CDS" gene 1289186..1290523 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /label="ykvU gene" CDS 1290574..1291071 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" /label="stoA CDS" gene 1290574..1291071 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /label="stoA gene" promotor_-35 1290920..1290926 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1290935 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1290941..1290959 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1291045 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1291166..1291172 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1291183..1291202 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1291195 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1291199..1291306 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1291307..1293220 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" /label="pfeT CDS" gene 1291307..1293220 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /label="pfeT gene" promotor_-10 complement(1291456..1291475) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1291473) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1291488..1291497) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1291624..1291643) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1291649) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1291657..1291663) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1293201 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1293277) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1293488..1293507) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1293497) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1293521..1293528) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1293572..1293591 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1293582 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="upshifts" CDS 1293627..1294718 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" /label="papB CDS" gene 1293627..1294718 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /label="papB gene" downshifts 1294367 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts 1294697 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" S_feature complement(1294731..1294949) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1294742..1294999 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1294936..1294955) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1294949) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1294971..1294978) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1295000..1295965 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" /label="ykvZ CDS" gene 1295000..1295965 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /label="ykvZ gene" promotor_-35 1295983..1295990 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1296005..1296024 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1296017 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="upshifts" CDS 1296028..1296894 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" /label="glcT CDS" gene 1296028..1296894 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /label="glcT gene" promotor_-35 1296749..1296753 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1296770..1296789 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1296778 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" downshifts 1296896 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_RNA 1296941..1297092 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" /label="gswA RNA" S_feature 1296941..1297092 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1296941..1297092 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /label="gswA gene" promotor_-35 1297070..1297076 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1297090..1297101 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1297094 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="upshifts" CDS 1297123..1299222 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" /label="ptsG CDS" gene 1297123..1299222 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /label="ptsG gene" promotor_-35 1299240..1299244 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1299260..1299279 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1299271 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1299320..1299586 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" /label="ptsH CDS" gene 1299320..1299586 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /label="ptsH gene" CDS 1299586..1301298 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" /label="ptsI CDS" gene 1299586..1301298 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /label="ptsI gene" downshifts 1301285 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-35 1301338..1301344 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1301359..1301370 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1301362 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1301389..1301628 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" /label="splA CDS" gene 1301389..1301628 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /label="splA gene" S_feature complement(1301409..1302748) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1301706..1302734 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" /label="splB CDS" gene 1301706..1302734 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /label="splB gene" downshifts 1302704 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1302749..1303429) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" /label="ykwB CDS" gene complement(1302749..1303429) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /label="ykwB gene" promotor_-10 complement(1303439..1303458) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1303462) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1303473..1303480) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1303514..1303521 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1303535..1303553 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1303541 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="upshifts" CDS 1303564..1305531 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" /label="mcpC CDS" gene 1303564..1305531 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /label="mcpC gene" misc_feature complement(1304004..1304019) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1304016) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1305502 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1305575..1305577 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1305593..1305612 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1305603 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1305645) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" /label="downshifts" CDS 1305669..1306535 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" /label="ohaC CDS" gene 1305669..1306535 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /label="ohaC gene" downshifts 1306515 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1306574..1307347) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" /label="ykwD CDS" gene complement(1306574..1307347) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /label="ykwD gene" downshifts complement(1306591) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1307379..1307398) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1307389) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1307622..1307641 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1307635 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1307637..1307740 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1307684..1309798 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" /label="pbpH CDS" gene 1307684..1309798 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /label="pbpH gene" promotor_-10 complement(1308977..1308995) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1308989) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1309011..1309016) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1309779 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" /label="downshifts" promotor_-35 1309871..1309879 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1309891..1309909 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1309903 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="upshifts" CDS 1309962..1311782 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" /label="kinA CDS" gene 1309962..1311782 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /label="kinA gene" CDS complement(1311793..1312974) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" /label="dapX CDS" gene complement(1311793..1312974) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /label="dapX gene" downshifts complement(1311827) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1313002..1313021) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1313018) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1313050..1313068) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1313062) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1313064..1313132) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1313083..1313088) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1313126..1313145) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1313132) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1313176..1313337) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" /label="ykzT CDS" gene complement(1313176..1313337) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /label="ykzT gene" promotor_-10 complement(1313360..1313379) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1313373) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1313393..1313400) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1313474..1313481 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1313493 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1313494..1313512 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1313541..1314452 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" /label="cheV CDS" gene 1313541..1314452 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /label="cheV gene" downshifts complement(1313546) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" /label="downshifts" promotor_-35 1313995..1314003 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1314017..1314034 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1314020 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1314437 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1314496..1314960) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" /label="kre CDS" gene complement(1314496..1314960) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /label="kre gene" downshifts complement(1314514) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1314990..1315009) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1315000) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1315024..1315031) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1315086..1316378) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" /label="ykuC CDS" gene complement(1315086..1316378) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /label="ykuC gene" downshifts complement(1315108) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1316402..1316421) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1316406) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="upshifts" promotor_-35 complement(1316437..1316441) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1316454..1316948) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" /label="ltdD CDS" gene complement(1316454..1316948) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /label="ltdD gene" promotor_-10 complement(1316964..1316983) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1316980) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1316997..1317006) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1317005..1317865) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" /label="ppeE CDS" gene complement(1317005..1317865) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /label="ppeE gene" misc_feature complement(1317886..1317905) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1317899) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="upshifts" promotor_-35 1317936..1317943 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1317959..1317978 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1317972 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="upshifts" CDS 1318008..1318772 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" /label="fadH CDS" gene 1318008..1318772 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /label="fadH gene" S_feature 1318773..1318921 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1318902..1318920 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1318923..1319072 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1318923 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1318970) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" /label="downshifts" CDS 1319073..1320803 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" /label="ykuG CDS" gene 1319073..1320803 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /label="ykuG gene" CDS 1320869..1321387 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" /label="ykzU CDS" gene 1320869..1321387 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /label="ykzU gene" downshifts 1321385 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 1321430..1321435 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1321448..1321467 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1321451 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="upshifts" CDS 1321483..1322031 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" /label="ykuH CDS" gene 1321483..1322031 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /label="ykuH gene" S_feature 1322032..1322183 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1322184..1323407 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" /label="ykuI CDS" gene 1322184..1323407 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /label="ykuI gene" promotor_-10 complement(1323370..1323388) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1323380) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1323386 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(1323403..1323408) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1323456..1323463 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1323475..1323576 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1323475 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1323478..1323497 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1323493..1323576 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" /label="fsrA RNA" gene 1323493..1323576 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /label="fsrA gene" downshifts 1323533 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 1323587..1323592 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1323607..1323891 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1323607 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1323609..1323627 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1323868..1323874 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1323888..1323899 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1323893..1323980 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1323893 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" misc_feature 1323969..1323988 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1323982 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1324053..1324292 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" /label="ykuJ CDS" gene 1324053..1324292 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /label="ykuJ gene" S_feature 1324293..1324401 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1324402..1324920 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" /label="ykuK CDS" gene 1324402..1324920 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /label="ykuK gene" promotor_-35 1324957..1324964 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1324978..1324997 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1324992 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1325054..1325251 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" /label="abbA CDS" gene 1325054..1325251 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /label="abbA gene" downshifts 1325247 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" /label="downshifts" S_feature 1325292..1325388 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1325389..1325832 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" /label="ykuL CDS" gene 1325389..1325832 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /label="ykuL gene" S_feature 1325833..1325940 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1325908..1325913 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1325928..1325947 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1325942 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1325981..1326862 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" /label="ccpC CDS" gene 1325981..1326862 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /label="ccpC gene" downshifts 1326841 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1326897..1326904 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1326919..1326938 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1326924 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1326974..1327450 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" /label="fldN CDS" gene 1326974..1327450 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /label="fldN gene" CDS 1327440..1328333 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" /label="ykuO CDS" gene 1327440..1328333 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /label="ykuO gene" CDS 1328349..1328804 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" /label="fldP CDS" gene 1328349..1328804 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /label="fldP gene" promotor_-10 complement(1328620..1328639) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1328633) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1328653..1328661) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1328798 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" /label="downshifts" promotor_-35 1328843..1328850 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1328864..1328883 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1328865 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1328909..1329619 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" /label="dapH CDS" gene 1328909..1329619 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /label="dapH gene" downshifts complement(1328918) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1329028..1329032) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1329028) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1329689..1330813 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" /label="dapI CDS" gene 1329689..1330813 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /label="dapI gene" promotor_-35 1330825..1330831 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1330845..1330856 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1330847 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1330851..1330865) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1330875..1330879) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1330875..1331120 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" /label="ykuS CDS" gene 1330875..1331120 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /label="ykuS gene" upshifts complement(1330876) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1331108 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1331153..1332103 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1331157..1331960) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" /label="mscT CDS" gene complement(1331157..1331960) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /label="mscT gene" downshifts complement(1331169) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1332011..1332030) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1332020) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1332044..1332051) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1332076..1332083 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1332098..1332117 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1332105..1332196 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1332105 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="upshifts" CDS 1332197..1332739 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" /label="ahpA CDS" gene 1332197..1332739 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /label="ahpA gene" CDS 1332811..1333257 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" /label="ykuV CDS" gene 1332811..1333257 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /label="ykuV gene" downshifts 1333265 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1333650..1333657 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1333670 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1333672..1333691 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1333723..1334298 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" /label="rok CDS" gene 1333723..1334298 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /label="rok gene" downshifts 1334276 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1334339..1335304) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" /label="sppO CDS" gene complement(1334339..1335304) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /label="sppO gene" downshifts complement(1334352) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1334648..1334649 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1334667..1334686 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1334673..1335397 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1334673 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1335325..1335343) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1335346) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1335358..1335363) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1335384..1335390 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1335400 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1335404..1335423 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1335441..1336040 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" /label="mobA CDS" gene 1335441..1336040 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /label="mobA gene" CDS 1336091..1337110 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" /label="moeB CDS" gene 1336091..1337110 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /label="moeB gene" CDS 1337128..1338420 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" /label="moeA CDS" gene 1337128..1338420 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /label="moeA gene" CDS 1338381..1338902 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" /label="mobB CDS" gene 1338381..1338902 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /label="mobB gene" CDS 1338902..1339375 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" /label="moaE CDS" gene 1338902..1339375 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /label="moaE gene" CDS 1339368..1339601 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" /label="moaD CDS" gene 1339368..1339601 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /label="moaD gene" downshifts 1339580 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1339646..1339651 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1339668..1339686 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1339676 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="upshifts" S_feature 1339688..1339774 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1339764..1339767 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1339776 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1339782..1339801 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1339825..1341582 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" /label="yknU CDS" gene 1339825..1341582 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /label="yknU gene" CDS 1341594..1343408 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" /label="yknV CDS" gene 1341594..1343408 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /label="yknV gene" promotor_-10 complement(1342031..1342050) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1342041) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1342065..1342072) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1343459..1343468 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1343480..1343495 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1343484 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="upshifts" CDS 1343518..1344213 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" /label="skiW CDS" gene 1343518..1344213 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /label="skiW gene" CDS 1344218..1345351 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" /label="skiX CDS" gene 1344218..1345351 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /label="skiX gene" CDS 1345352..1346044 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" /label="skiY CDS" gene 1345352..1346044 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /label="skiY gene" CDS 1346041..1347234 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" /label="skiZ CDS" gene 1346041..1347234 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /label="skiZ gene" downshifts 1347212 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" /label="downshifts" promotor_-35 1347283..1347289 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1347303..1347314 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1347311 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1347356..1347363 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1347378..1347397 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1347383..1347474 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1347383 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="upshifts" promotor_-35 1347438..1347445 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1347459..1347478 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1347476 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="upshifts" CDS 1347514..1348269 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" /label="fruR CDS" gene 1347514..1348269 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /label="fruR gene" upshifts complement(1347662) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1347664..1347666) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1348266..1349177 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" /label="fruK CDS" gene 1348266..1349177 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /label="fruK gene" CDS 1349192..1351099 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" /label="fruA CDS" gene 1349192..1351099 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /label="fruA gene" downshifts 1351084 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1351168..1351175 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1351186..1351205 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1351189 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="upshifts" CDS 1351244..1351825 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" /label="sipT CDS" gene 1351244..1351825 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /label="sipT gene" downshifts 1351810 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1351854 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1351859..1352128) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" /label="ykoA CDS" gene complement(1351859..1352128) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /label="ykoA gene" downshifts complement(1351864) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(1352129..1352194) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1352175..1352194) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1352194) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1352247..1352254 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1352265..1352284 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1352269 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="upshifts" CDS 1352309..1353931 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" /label="ykpA CDS" gene 1352309..1353931 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /label="ykpA gene" downshifts 1353919 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" /label="downshifts" CDS 1353988..1354899 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" /label="panE CDS" gene 1353988..1354899 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /label="panE gene" downshifts 1354904 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1354933..1356165) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" /label="ampS CDS" gene complement(1354933..1356165) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /label="ampS gene" downshifts complement(1354944) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1356183..1356202) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1356207) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1356217..1356222) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1356275..1356409) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" /label="ykpC CDS" gene complement(1356275..1356409) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /label="ykpC gene" downshifts complement(1356286) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1356431..1356449) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1356442) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1356444..1356509) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1356465..1356470) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1356510..1357517) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" /label="mreBH CDS" gene complement(1356510..1357517) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /label="mreBH gene" upshifts complement(1357563) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1357564..1357572) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1357586..1357594) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1357704..1357713 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1357725 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="upshifts" promotor_-10 1357726..1357741 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1357728..1357800 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1357801..1358079 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" /label="abhA CDS" gene 1357801..1358079 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /label="abhA gene" downshifts 1358077 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" /label="downshifts" S_feature complement(1358111..1359740) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1358122..1358226 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1358134) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1358208..1358215 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1358227..1358246 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1358228 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="upshifts" CDS 1358269..1359555 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" /label="kinC CDS" gene 1358269..1359555 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /label="kinC gene" CDS 1359571..1360404 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" /label="ykqA CDS" gene 1359571..1360404 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /label="ykqA gene" promotor_-10 complement(1359737..1359755) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1359752) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1359771..1359776) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1360467..1361132 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" /label="ktrC CDS" gene 1360467..1361132 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /label="ktrC gene" downshifts 1361116 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1361223..1361229 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1361244..1361263) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1361244..1361263 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1361256 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1361258) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1361287..1363020 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" /label="adeC CDS" gene 1361287..1363020 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /label="adeC gene" S_feature complement(1362415..1363019) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1363009 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1363054..1364721) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" /label="rnjA CDS" gene complement(1363054..1364721) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /label="rnjA gene" downshifts complement(1363064) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1364727..1364936) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" /label="rnpZA CDS" gene complement(1364727..1364936) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /label="rnpZA gene" promotor_-10 complement(1364973..1364992) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1364995) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1364997..1365174) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1365007..1365010) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1365175) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1365177..1365188) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1365202..1365208) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1365247..1365254 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1365268..1365287 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1365284 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1365322..1366095 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" /label="ykrA CDS" gene 1365322..1366095 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /label="ykrA gene" downshifts 1366066 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1366131..1366685) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" /label="defB CDS" gene complement(1366131..1366685) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /label="defB gene" downshifts complement(1366142) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1366707..1366726) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1366717) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1366741..1366748) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1366770 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1366794) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(1366795..1366953) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" /label="ykzV CDS" gene complement(1366795..1366953) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /label="ykzV gene" CDS complement(1366860..1367003) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" /label="putative antitoxin CDS" gene complement(1366860..1367003) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /label="gene" promotor_-35 1366949..1366953 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1366954..1367022) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1366963..1366977 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1366990 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1367006..1367025) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1367035) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1367038..1367047) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1367109..1367116 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1367130..1367149 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1367134 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1367167..1367838 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" /label="ykyA CDS" gene 1367167..1367838 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /label="ykyA gene" promotor_-35 1367506..1367515 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1367528..1367546 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1367540 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1367785 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 1368013..1368018 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1368035..1368054 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1368036..1368261 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1368036 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1368040..1368059) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1368056) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1368160..1368168) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1368166) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1368182..1368190) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1368262..1369377 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" /label="pdhA CDS" gene 1368262..1369377 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /label="pdhA gene" CDS 1369381..1370358 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" /label="pdhB CDS" gene 1369381..1370358 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /label="pdhB gene" S_feature 1370359..1370472 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1370393..1370412) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1370410) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1370427..1370430) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1370473..1371801 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" /label="pdhC CDS" gene 1370473..1371801 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /label="pdhC gene" promotor_-35 1370617..1370624 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1370639..1370658 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1370642 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="upshifts" CDS 1371806..1373218 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" /label="pdhD CDS" gene 1371806..1373218 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /label="pdhD gene" downshifts 1373215 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1373263..1373637) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" /label="slp CDS" gene complement(1373263..1373637) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /label="slp gene" downshifts complement(1373311) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(1373668..1373687) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1373678) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1373841..1373846 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1373862..1373880 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1373872 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="upshifts" S_feature 1373876..1373985 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1373908) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1373969..1373976 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1373987 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1373991..1374010 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1374006..1374216 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" /label="srrA RNA" gene 1374006..1374216 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /label="srrA gene" CDS 1374056..1374175 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" /label="rgpA CDS" gene 1374056..1374175 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /label="rgpA gene" downshifts complement(1374062) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts 1374162 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1374207..1375810 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1374215..1375687) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" /label="speA CDS" gene complement(1374215..1375687) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /label="speA gene" downshifts complement(1374233) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(1375688..1375783) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1375766..1375785) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1375783) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1375790..1375793 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1375800..1375807) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1375808..1375827 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1375812 /Source="Nicolas_upshifts" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="upshifts" CDS 1375872..1376138 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389347.1" /db_xref="EnsemblGenomes-Gn:BSU14640" /db_xref="EnsemblGenomes-Tr:CAB13337" /db_xref="InterPro:IPR007920" /db_xref="InterPro:IPR023324" /db_xref="SubtiList:BG11816" /db_xref="UniProtKB/Swiss-Prot:Q45497" /translation="MEYQYPMNEDWTTEEAVDVIAFFQQVELAYEKGADREELLKAYR RFKEIVPGKAEEKKLCGEFEEQSTYSPYRTVKQARESDHAKIKM*" /label="yktA CDS" gene 1375872..1376138 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /label="yktA gene" downshifts 1376120 /Source="Nicolas_upshifts" /id="D825" /incds=0 /nref=105 /ntot=250 /MaxReadThrough="2.62284" /MaxDrop="5.09814" /score="40.0811023" /energy="-16.1" /TU="NA" /idTUdmin="U1214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1376171..1376809) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25643072" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389348.1" /db_xref="EnsemblGenomes-Gn:BSU14650" /db_xref="EnsemblGenomes-Tr:CAB13338" /db_xref="InterPro:IPR009403" /db_xref="PDB:2A8E" /db_xref="SubtiList:BG11817" /db_xref="UniProtKB/Swiss-Prot:Q45498" /translation="MTQMRFTEEDFNTFTIEGLDARMEVLKETVRPKLTALGEHFAPT LSALTGDEMFPHVAKHARRSVNPPADSWVAFANSKRGYKKLPHFQIGLWESHVFVWFA IIYESPIKEEYGKLLEVNQETITKNIPDSFVWSADHTKPGVHKQSEMDKEQLKTLFER LQTVKKAELLCGIQLQKEEVLNMNNQEFLQRIDDAFKQLAFLYRLTQKVTQA*" /label="yktB CDS" gene complement(1376171..1376809) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /label="yktB gene" downshifts complement(1376196) /Source="Nicolas_upshifts" /id="D826" /incds=0 /nref=184 /ntot=257 /MaxReadThrough="2.62959" /MaxDrop="6.54203" /score="26.7765804" /energy="-14.5" /TU="U1217" /idTUdmin="U1217" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1376830..1376849) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1376854) /Source="Nicolas_upshifts" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1376864..1376868) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1376879..1376885 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1376900..1376918 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1376901 /Source="Nicolas_upshifts" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1376939..1376948 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1376961..1376980 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1376965..1377048 /Source="Nicolas_S_feature" /locus_tag="new_1537029_1537112" /HighExp="Etha, S7, M9-stat, S6, S8, BT, Gly, Salt, B60, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S536" upshifts 1376965 /Source="Nicolas_upshifts" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1377049..1377237 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved general stress protein" /protein_id="NP_389349.1" /db_xref="EnsemblGenomes-Gn:BSU14660" /db_xref="EnsemblGenomes-Tr:CAB13339" /db_xref="SubtiList:BG13337" /db_xref="UniProtKB/Swiss-Prot:O31719" /translation="MRQVVKEGFKEEKNNRVAVWRLEVDYELATLYEAMQKENEEQIE QSKNKLERLRKEWIRLNG*" /label="ykzI CDS" gene 1377049..1377237 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /label="ykzI gene" downshifts complement(1377054) /Source="Nicolas_upshifts" /id="D827" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="1.50398" /MaxDrop="3.97385" /score="26.7765804" /energy="-14.5" /TU="NA" /idTUdmin="U1220" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1377230 /Source="Nicolas_upshifts" /id="D828" /incds=0 /nref=13 /ntot=45 /MaxReadThrough="7.33866" /MaxDrop="6.12123" /score="-8.73613673" /energy="-8.1" /TU="U1218,U1219" /idTUdmin="U1219" /TUdmin="-628" /isTUend="FALSE" /label="downshifts" upshifts complement(1377252) /Source="Nicolas_upshifts" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1377260..1377263) /Source="Nicolas_upshift_promotors" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1377307..1377310 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1377327..1377346 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1377330 /Source="Nicolas_upshifts" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" CDS 1377377..1378174 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /EC_number="3.1.3.-" /EC_number="3.1.3.25" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914086, 16682444, 22333191, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914086, 16682444, 22333191, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inositol monophosphatase / 5' nucleotidase (purine nucleoside monophosphate)" /protein_id="NP_389350.1" /db_xref="EnsemblGenomes-Gn:BSU14670" /db_xref="EnsemblGenomes-Tr:CAB13340" /db_xref="GOA:Q45499" /db_xref="InterPro:IPR000760" /db_xref="InterPro:IPR020550" /db_xref="InterPro:IPR020583" /db_xref="InterPro:IPR033942" /db_xref="SubtiList:BG11818" /db_xref="UniProtKB/Swiss-Prot:Q45499" /translation="MTNWTEIDEIAKKWIREAGARITQSMHESLTIETKSNPNDLVTN IDKETEKFFIDRIQETFPGHRILGEEGQGDKIHSLEGVVWIIDPIDGTMNFVHQQRNF AISIGIFENGEGKIGLIYDVVHDELYHAFSGRGAYMNETKLAPLKETVIEEAILAINA TWVTENRRIDQSVLAPLVKRVRGTRSYGSAALELANVAAGRIDAYITMRLAPWDYAAG CVLLNEVGGTYTTIEGEPFTFLENHSVLAGNPSIHKTIFEEYLHARK*" /label="suhB CDS" gene 1377377..1378174 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /label="suhB gene" CDS 1378200..1378628 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389351.1" /db_xref="EnsemblGenomes-Gn:BSU14680" /db_xref="EnsemblGenomes-Tr:CAB13341" /db_xref="GOA:O31720" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13331" /db_xref="UniProtKB/Swiss-Prot:O31720" /translation="MLEKLAEAHPVWKEEEFGDKDAEDYIISYSMYNGSWLVWEKDGM PVAVSYHLEWSPSNGKPWLGTVLIDPAEEKKGHAKMIIEQISKLLRAKHKAMFAGVPI ERREWILFLSQCGFEQLKTEKDEKGKSFMILVKPLAEAAV*" /label="ykzC CDS" gene 1378200..1378628 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /label="ykzC gene" downshifts 1378585 /Source="Nicolas_upshifts" /id="D829" /incds=0 /nref=80 /ntot=232 /MaxReadThrough="4.50069" /MaxDrop="4.3098" /score="-9.99315734" /energy="-11.8" /TU="U1218,U1221" /idTUdmin="U1218" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" S_feature 1378629..1379582 /Source="Nicolas_S_feature" /locus_tag="new_1538693_1539646" /HighExp="H2O2, dia15, Diami, Paraq, G180, G135, G150, dia5, Heat, LBGexp" /AntisenseName="yktD" /AntisenseCor="-1.5120906229522399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="0.117724" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S537" downshifts complement(1378704) /Source="Nicolas_upshifts" /id="D830" /incds=0 /nref=4 /ntot=85 /MaxReadThrough="0.88821" /MaxDrop="3.44773" /score="19.9363134" /energy="-12.8" /TU="NA" /idTUdmin="U1222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1378706..1379620) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_389352.1" /db_xref="EnsemblGenomes-Gn:BSU14690" /db_xref="EnsemblGenomes-Tr:CAB13342" /db_xref="GOA:Q45500" /db_xref="InterPro:IPR007213" /db_xref="InterPro:IPR011610" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11819" /db_xref="UniProtKB/Swiss-Prot:Q45500" /translation="MRKNESSLTSLISAFARAYHSRYDTPLIFDDFIAKDLINEKEFI DISKNMIQEISFFNKEIAERLQNDPEKILKWVAQIQLSPTPLARASYCEKVLHNELIL GAKQYVILGAGLDTFCFRHPELENSLQVFEVDHPATQQLKKNKLKDANLTIPGHLHFV PMDFTKTFSYDPLLDEGFKNTKTFFSLLGVSYYVTREENASLISNLFSHVPPGSSIVF DYADETLFTAKGTSNRVEHMVKMAAASGEPMKSCFTYQEIEHLLESSGLLIYEHLSPD DINDLFFSNRKDNLSAFETIHYIHAVKK*" /label="yktD CDS" gene complement(1378706..1379620) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /label="yktD gene" promotor_-10 complement(1379686..1379705) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1379694) /Source="Nicolas_upshifts" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1379720..1379727) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1379972..1381537) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /EC_number="3.4.24.28" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2128597, 6090407, 8436952, 15205417, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2128597, 6090407, 8436952, 15205417, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral metalloprotease" /protein_id="NP_389353.1" /db_xref="EnsemblGenomes-Gn:BSU14700" /db_xref="EnsemblGenomes-Tr:CAB13343" /db_xref="GOA:P68736" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10448" /db_xref="UniProtKB/Swiss-Prot:P68736" /translation="MGLGKKLSVAVAASFMSLSISLPGVQAAEGHQLKENQTNFLSKN AIAQSELSAPNDKAVKQFLKKNSNIFKGDPSKRLKLVESTTDALGYKHFRYAPVVNGV PIKDSQVIVHVDKSDNVYAVNGELHNQSAAKTDNSQKVSSEKALALAFKAIGKSPDAV SNGAAKNSNKAELKAIETKDGSYRLAYDVTIRYVEPEPANWEVLVDAETGSILKQQNK VEHAAATGSGTTLKGATVPLNISYEGGKYVLRDLSKPTGTQIITYDLQNRQSRLPGTL VSSTTKTFTSSSQRAAVDAHYNLGKVYDYFYSNFKRNSYDNKGSKIVSSVHYGTQYNN AAWTGDQMIYGDGDGSFFSPLSGSLDVTAHEMTHGVTQETANLIYENQPGALNESFSD VFGYFNDTEDWDIGEDITVSQPALRSLSNPTKYNQPDNYANYRNLPNTDEGDYGGVHT NSGIPNKAAYNTITKLGVSKSQQIYYRALTTYLTPSSTFKDAKAALIQSARDLYGSTD AAKVEAAWNAVGL*" /label="nprE CDS" gene complement(1379972..1381537) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /label="nprE gene" promotor_-10 complement(1381572..1381591) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1381583) /Source="Nicolas_upshifts" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1381605..1381612) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1381822..1383762 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" /label="ylaA CDS" gene 1381822..1383762 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /label="ylaA gene" CDS 1383752..1384021 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" /label="ylaB CDS" gene 1383752..1384021 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /label="ylaB gene" promotor_-35 1383987..1383991 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1384005..1384024 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1384018 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1384021..1384542 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" /label="sigP CDS" gene 1384021..1384542 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /label="sigP gene" CDS 1384539..1384832 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" /label="sigQ CDS" gene 1384539..1384832 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /label="sigQ gene" CDS complement(1384872..1385483) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" /label="ylaE CDS" gene complement(1384872..1385483) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /label="ylaE gene" downshifts complement(1384886) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1385515..1385534) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1385524) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1385549..1385552) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1385739) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1385756..1385944) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" /label="ylaF CDS" gene complement(1385756..1385944) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /label="ylaF gene" downshifts complement(1385810) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1385966..1385985) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1385983) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1385998..1386005) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1386011..1386030 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1386018 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="upshifts" CDS 1386057..1387895 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" /label="bipA CDS" gene 1386057..1387895 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /label="bipA gene" CDS 1387952..1388269 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" /label="ylaH CDS" gene 1387952..1388269 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /label="ylaH gene" downshifts 1388243 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(1388318) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1388325..1388534) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" /label="ylaI CDS" gene complement(1388325..1388534) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /label="ylaI gene" misc_feature complement(1388548..1388567) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1388563) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1388617..1389246) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" /label="ylaJ CDS" gene complement(1388617..1389246) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /label="ylaJ gene" downshifts complement(1388648) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1389148..1389166) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1389154) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1389178..1389186) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1389281..1389292) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1389286) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1389298..1389303 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1389307..1389313) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1389319..1389337 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1389319 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="upshifts" S_feature 1389320..1389400 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1389401..1390729 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" /label="ylaK CDS" gene 1389401..1390729 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /label="ylaK gene" S_feature complement(1390585..1390732) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1390628) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 1390730..1391320 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1390733..1391218) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" /label="ylaL CDS" gene complement(1390733..1391218) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /label="ylaL gene" promotor_-10 complement(1391230..1391249) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1391258) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1391264..1391271) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1391321..1392250 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" /label="glsB CDS" gene 1391321..1392250 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /label="glsB gene" misc_feature 1391835..1391854 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1391844 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="upshifts" promotor_-35 1392274..1392277 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1392292..1392311 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1392300 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1392348..1392629 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" /label="ylaN CDS" gene 1392348..1392629 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /label="ylaN gene" downshifts 1392618 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" /label="downshifts" promotor_-35 1392692..1392695 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1392708..1392834 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1392708 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1392713..1392719 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1392835..1394046 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" /label="ftsW CDS" gene 1392835..1394046 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /label="ftsW gene" promotor_-35 1394056..1394060 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1394075..1394094 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1394094 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1394121..1397567 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" /label="pycA CDS" gene 1394121..1397567 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /label="pycA gene" promotor_-10 complement(1397133..1397151) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1397153) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1397167..1397172) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1397547 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts 1397592 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" /label="downshifts" downshifts complement(1397624) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 1397636 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(1397970..1398890) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" /label="ctaA CDS" gene complement(1397970..1398890) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /label="ctaA gene" downshifts complement(1397976) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1398930..1398949) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1398945) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1398963..1398970) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1399025..1399032 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1399046..1399065 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1399047..1399152 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1399047 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" S_feature 1399154..1399244 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1399154 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1399160..1399163 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1399178..1399194 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1399245..1400162 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" /label="ctaB CDS" gene 1399245..1400162 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /label="ctaB gene" downshifts 1400191 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" /label="downshifts" upshifts 1400210 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1400211..1400216 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1400270..1400275 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1400290..1400308 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1400298..1400401 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1400298 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" CDS 1400402..1401472 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" /label="ctaC CDS" gene 1400402..1401472 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /label="ctaC gene" CDS 1401505..1403373 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" /label="ctaD CDS" gene 1401505..1403373 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /label="ctaD gene" CDS 1403373..1403996 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" /label="ctaE CDS" gene 1403373..1403996 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /label="ctaE gene" CDS 1403999..1404331 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" /label="ctaF CDS" gene 1403999..1404331 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /label="ctaF gene" CDS 1404358..1405251 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" /label="ctaG CDS" gene 1404358..1405251 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /label="ctaG gene" downshifts 1405226 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1405283..1405645) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" /label="ylbA CDS" gene complement(1405283..1405645) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /label="ylbA gene" downshifts complement(1405302) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1405638..1405642 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1405651..1405664 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1405669..1405688) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1405673..1405784 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1405673 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1405681) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1405703..1405710) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1405785..1406231 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" /label="ylbB CDS" gene 1405785..1406231 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /label="ylbB gene" promotor_-35 1405817..1405824 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1405836..1405855 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1405841 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1406240..1406247 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1406261..1406280 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1406272 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" CDS 1406315..1407355 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" /label="ylbC CDS" gene 1406315..1407355 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /label="ylbC gene" promotor_-10 complement(1407278..1407296) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1407283) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1407312..1407317) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1407335 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 1407519..1407528 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1407542..1407561 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1407556 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="upshifts" CDS 1407587..1407985 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" /label="ylbD CDS" gene 1407587..1407985 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /label="ylbD gene" downshifts complement(1407591) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS 1408001..1408240 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" /label="ylbE CDS" gene 1408001..1408240 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /label="ylbE gene" downshifts 1408219 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1408307..1408314 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1408325..1408344 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1408330 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1408356..1408805 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" /label="ricF CDS" gene 1408356..1408805 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /label="ricF gene" downshifts 1408791 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" /label="downshifts" CDS 1408860..1409132 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" /label="ylbG CDS" gene 1408860..1409132 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /label="ylbG gene" S_feature complement(1408937..1409160) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1409135..1409255 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" /label="csfG RNA" gene 1409135..1409255 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /label="csfG gene" S_feature complement(1409162..1409285) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1409205) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" /label="downshifts" S_feature 1409256..1409361 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1409286..1409298) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1409293) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1409313..1409319) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1409342..1409346 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1409362..1409381 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1409363..1409454 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1409363 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="upshifts" CDS 1409455..1410009 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" /label="rsmD CDS" gene 1409455..1410009 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /label="rsmD gene" CDS 1410014..1410499 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" /label="coaD CDS" gene 1410014..1410499 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /label="coaD gene" downshifts 1410466 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" /label="downshifts" CDS complement(1410510..1411736) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" /label="spoVV CDS" gene complement(1410510..1411736) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /label="spoVV gene" S_feature 1410511..1411785 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1411737..1411838) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1411760..1411767 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1411779..1411798 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1411787..1411916 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1411787 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1411833..1411851) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1411848) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1411868..1411873) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1411917..1412699 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" /label="ylbK CDS" gene 1411917..1412699 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /label="ylbK gene" promotor_-35 1412479..1412485 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1412499..1412510 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1412510 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1412701..1413726 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" /label="ylbL CDS" gene 1412701..1413726 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /label="ylbL gene" downshifts 1413610 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1413743..1414990) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" /label="ylbM CDS" gene complement(1413743..1414990) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /label="ylbM gene" downshifts complement(1413770) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" /label="downshifts" promotor_-35 1414907..1414913 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1414927..1414938 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1414931 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="upshifts" CDS complement(1414987..1415172) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" /label="ylzH CDS" gene complement(1414987..1415172) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /label="ylzH gene" promotor_-35 1415005..1415009 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1415025..1415044 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1415034..1415169 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1415034 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="upshifts" promotor_-10 complement(1415063..1415082) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1415073) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1415096..1415103) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1415140..1415147 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1415161..1415180 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1415171 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1415200..1415718 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" /label="ylbN CDS" gene 1415200..1415718 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /label="ylbN gene" CDS 1415740..1415919 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" /label="rpmF CDS" gene 1415740..1415919 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /label="rpmF gene" downshifts 1415899 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1415942) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1415946..1415949) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1416000..1416005 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1416021..1416039 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1416022 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1416065..1416646 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" /label="gerR CDS" gene 1416065..1416646 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /label="gerR gene" downshifts 1416647 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1416703..1417185) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" /label="ylbP CDS" gene complement(1416703..1417185) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /label="ylbP gene" downshifts complement(1416722) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" /label="downshifts" downshifts 1417175 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1417208..1417227) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1417227) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1417241..1417248) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1417285..1417291 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1417303..1417322 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1417305 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="upshifts" CDS 1417345..1418241 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" /label="panE CDS" gene 1417345..1418241 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /label="panE gene" CDS 1418312..1419931 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" /label="bshC CDS" gene 1418312..1419931 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /label="bshC gene" downshifts 1419903 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 1419965..1419968 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1419983..1420056 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1419983..1420002 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1419983 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1420040) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" /label="downshifts" CDS 1420057..1420488 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" /label="mraZ CDS" gene 1420057..1420488 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /label="mraZ gene" CDS 1420558..1421493 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" /label="rsmH CDS" gene 1420558..1421493 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /label="rsmH gene" S_feature complement(1421160..1422612) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1421533..1421886 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" /label="ftsL CDS" gene 1421533..1421886 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /label="ftsL gene" CDS 1421883..1424033 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" /label="pbpB CDS" gene 1421883..1424033 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /label="pbpB gene" promotor_-10 complement(1422593..1422611) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1422612) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1422626..1422632) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1424016 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1424088..1424093 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1424109..1424127 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1424109 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="upshifts" CDS 1424150..1426090 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" /label="spoVD CDS" gene 1424150..1426090 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /label="spoVD gene" promotor_-35 1425886..1425892 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1425907..1425915 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1425913 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="upshifts" downshifts 1426063 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" /label="downshifts" S_feature 1426108..1426175 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1426145..1426149 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1426165..1426184 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1426177..1426265 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1426177 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" CDS 1426266..1427750 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" /label="murE CDS" gene 1426266..1427750 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /label="murE gene" S_feature 1427751..1427861 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1427862..1428836 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" /label="mraY CDS" gene 1427862..1428836 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /label="mraY gene" CDS 1428837..1430192 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" /label="murD CDS" gene 1428837..1430192 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /label="murD gene" promotor_-35 1430016..1430021 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1430037..1430055 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1430047 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="upshifts" CDS 1430253..1431353 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" /label="spoVE CDS" gene 1430253..1431353 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /label="spoVE gene" S_feature 1431354..1431475 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1431476..1432567 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" /label="murG CDS" gene 1431476..1432567 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /label="murG gene" promotor_-35 1431956..1431965 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1431978..1431993 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1431983 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" promotor_no_box 1431989..1432089 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1432049 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1432599..1433510 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" /label="murB CDS" gene 1432599..1433510 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /label="murB gene" downshifts 1433528 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" /label="downshifts" CDS 1433640..1434431 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" /label="divIB CDS" gene 1433640..1434431 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /label="divIB gene" CDS 1434428..1435123 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" /label="ylxW CDS" gene 1434428..1435123 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /label="ylxW gene" CDS 1435146..1435853 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" /label="ylxX CDS" gene 1435146..1435853 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /label="ylxX gene" CDS 1435871..1436236 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" /label="sbp CDS" gene 1435871..1436236 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /label="sbp gene" promotor_-35 1436088..1436091 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1436107..1436126 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1436123 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" S_feature 1436237..1436409 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1436410..1437732 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" /label="ftsA CDS" gene 1436410..1437732 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /label="ftsA gene" upshifts complement(1436617) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1436621..1436625) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1436640..1436644) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1437768..1438916 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" /label="ftsZ CDS" gene 1437768..1438916 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /label="ftsZ gene" downshifts 1438890 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR join(1439011,1439018) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs20" N_region 1439012..1439017 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs20" S_feature <1439018..1439063 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1439028..1439035 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1439048..1439067 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1439065 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1439122..1439916 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" /label="ylmA CDS" gene 1439122..1439916 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /label="ylmA gene" promotor_-35 1439834..1439837 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1439852..1439871 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1439860 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="upshifts" misc_RNA 1439929..1440030 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswE RNA" gene 1439929..1440030 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /label="tswE gene" downshifts 1440017 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" /label="downshifts" CDS 1440118..1441398 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" /label="thiQ CDS" gene 1440118..1441398 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /label="thiQ gene" misc_feature complement(1441339..1441355) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1441344) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1441419..1441424 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1441440..1441458 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1441444 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="upshifts" CDS 1441481..1441726 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" /label="ylmC CDS" gene 1441481..1441726 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /label="ylmC gene" promotor_-35 1441642..1441650 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1441661..1441679 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1441669 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1441727..1441837 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1441829..1441848 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1441839 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1441889..1442725 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" /label="ylmD CDS" gene 1441889..1442725 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /label="ylmD gene" CDS 1442732..1443424 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" /label="ylmE CDS" gene 1442732..1443424 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /label="ylmE gene" CDS 1443421..1443876 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" /label="sepF CDS" gene 1443421..1443876 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /label="sepF gene" CDS 1443883..1444155 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" /label="ylmG CDS" gene 1443883..1444155 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /label="ylmG gene" downshifts 1444144 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" CDS 1444216..1444989 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" /label="ylmH CDS" gene 1444216..1444989 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /label="ylmH gene" promotor_-35 1444705..1444712 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1444726..1444744 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1444749 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1444990..1445082 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1445083..1445577 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" /label="divIVA CDS" gene 1445083..1445577 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /label="divIVA gene" promotor_-35 1445590..1445597 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1445611..1445630 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1445618 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1445640..1445866 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /label="iswA RNA" gene 1445640..1445866 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /label="iswA gene" downshifts 1445833 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" /label="downshifts" CDS 1445919..1448684 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" /label="ileS CDS" gene 1445919..1448684 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /label="ileS gene" downshifts 1448675 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(1448730) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" /label="downshifts" promotor_-35 1448765..1448771 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1448786..1448797 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1448786 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="upshifts" CDS 1448829..1449203 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" /label="ylyA CDS" gene 1448829..1449203 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /label="ylyA gene" promotor_-35 1449235..1449239 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1449254 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" promotor_-10 1449255..1449274 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1449306..1449770 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" /label="lspA CDS" gene 1449306..1449770 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /label="lspA gene" CDS 1449772..1450683 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" /label="rluD CDS" gene 1449772..1450683 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /label="rluD gene" promotor_-35 1450678..1450685 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1450700..1450719 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1450714 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" misc_RNA 1450723..1450839 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaA RNA" gene 1450723..1450839 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /label="pyaA gene" CDS 1450866..1451411 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" /label="pyrR CDS" gene 1450866..1451411 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /label="pyrR gene" downshifts complement(1451060) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" /label="downshifts" downshifts 1451402 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" /label="downshifts" misc_RNA 1451415..1451532 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaB RNA" gene 1451415..1451532 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /label="pyaB gene" CDS 1451585..1452892 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" /label="pyrP CDS" gene 1451585..1452892 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /label="pyrP gene" misc_RNA 1452893..1453007 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaC RNA" gene 1452893..1453007 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /label="pyaC gene" CDS 1453038..1453952 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" /label="pyrB CDS" gene 1453038..1453952 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /label="pyrB gene" CDS 1453936..1455222 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" /label="pyrC CDS" gene 1453936..1455222 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /label="pyrC gene" CDS 1455219..1456313 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" /label="pyrAA CDS" gene 1455219..1456313 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /label="pyrAA gene" CDS 1456298..1459513 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" /label="pyrAB CDS" gene 1456298..1459513 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /label="pyrAB gene" CDS 1459510..1460280 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" /label="pyrK CDS" gene 1459510..1460280 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /label="pyrK gene" CDS 1460280..1461215 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" /label="pyrD CDS" gene 1460280..1461215 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /label="pyrD gene" CDS 1461184..1461903 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" /label="pyrF CDS" gene 1461184..1461903 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /label="pyrF gene" CDS 1461882..1462532 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" /label="pyrE CDS" gene 1461882..1462532 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /label="pyrE gene" downshifts 1462534 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" S_feature 1462579..1462651 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1462631..1462638 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1462652..1462671 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1462653 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1462677..1462782 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /label="mswE RNA" gene 1462677..1462782 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /label="mswE gene" S_feature 1462783..1462943 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1462944..1463645 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" /label="cysH CDS" gene 1462944..1463645 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /label="cysH gene" CDS 1463657..1464721 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" /label="cysP CDS" gene 1463657..1464721 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /label="cysP gene" CDS 1464770..1465918 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" /label="sat CDS" gene 1464770..1465918 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /label="sat gene" upshifts complement(1464859) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1464871..1464875) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1464893..1464894) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1465931..1466524 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" /label="cysC CDS" gene 1465931..1466524 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /label="cysC gene" S_feature 1466525..1466622 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1466623..1467396 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" /label="sumT CDS" gene 1466623..1467396 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /label="sumT gene" promotor_-35 1467301..1467308 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1467323..1467342 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1467324 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" CDS 1467399..1468184 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" /label="sirB CDS" gene 1467399..1468184 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /label="sirB gene" CDS 1468165..1468653 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" /label="sirC CDS" gene 1468165..1468653 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /label="sirC gene" downshifts 1468633 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1468680) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1468693..1470411) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" /label="fbnA CDS" gene complement(1468693..1470411) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /label="fbnA gene" promotor_-10 complement(1470433..1470452) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1470447..1470452 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1470447) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1470465..1470470) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1470468..1470486 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1470472 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="upshifts" CDS 1470527..1473199 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" /label="tcaB CDS" gene 1470527..1473199 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /label="tcaB gene" promotor_-10 complement(1471932..1471951) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1471943) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1471966..1471973) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1473205..1473224 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1473208..1473281 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1473208 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1473282..1474157 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" /label="yloC CDS" gene 1473282..1474157 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /label="yloC gene" CDS 1474234..1474503 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" /label="remA CDS" gene 1474234..1474503 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /label="remA gene" misc_feature complement(1474314..1474318) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1474319) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1474511..1475125 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" /label="gmk CDS" gene 1474511..1475125 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /label="gmk gene" CDS 1475129..1475332 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" /label="rpoZ CDS" gene 1475129..1475332 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /label="rpoZ gene" downshifts 1475321 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS 1475413..1476633 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" /label="coaBC CDS" gene 1475413..1476633 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /label="coaBC gene" S_feature complement(1476472..1477047) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1476630..1479047 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" /label="priA CDS" gene 1476630..1479047 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /label="priA gene" promotor_-10 complement(1477043..1477061) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1477047) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1477075..1477081) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1478898..1478902 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1478918..1478937 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1478929 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1479074..1479556 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" /label="defA CDS" gene 1479074..1479556 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /label="defA gene" CDS 1479561..1480514 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" /label="fmt CDS" gene 1479561..1480514 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /label="fmt gene" CDS 1480501..1481844 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" /label="rsmB CDS" gene 1480501..1481844 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /label="rsmB gene" CDS 1481848..1482939 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" /label="rlmN CDS" gene 1481848..1482939 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /label="rlmN gene" CDS 1482946..1483710 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" /label="prpC CDS" gene 1482946..1483710 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /label="prpC gene" downshifts 1482999 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" /label="downshifts" CDS 1483704..1485650 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" /label="prkC CDS" gene 1483704..1485650 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /label="prkC gene" promotor_-35 1485559..1485565 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1485579..1485597 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1485595 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1485665..1486561 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" /label="rsgA CDS" gene 1485665..1486561 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /label="rsgA gene" CDS 1486566..1487219 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " /label="rpe CDS" gene 1486566..1487219 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /label="rpe gene" promotor_-35 1487217..1487226 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1487240..1487259 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1487245 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="upshifts" CDS 1487292..1487936 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" /label="thiN CDS" gene 1487292..1487936 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /label="thiN gene" promotor_-35 1487697..1487703 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1487714 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="upshifts" promotor_-10 1487718..1487736 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1487827..1487832 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1487848..1487866 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1487861 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1487937..1488007 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1488008..1488088 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" /label="spoVM CDS" gene 1488008..1488088 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /label="spoVM gene" downshifts 1488103 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1488148..1488520 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1488161..1488349) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" /label="rpmB CDS" gene complement(1488161..1488349) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /label="rpmB gene" downshifts complement(1488177) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" downshifts complement(1488223) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1488350..1488442) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1488424..1488443) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1488442) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1488459..1488462) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1488493..1488500 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1488515..1488533 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1488522 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" promotor_-35 1488561..1488564 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1488579..1488598 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1488587 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" CDS 1488626..1488988 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" /label="yloU CDS" gene 1488626..1488988 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /label="yloU gene" downshifts complement(1488839) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1489004..1490665 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" /label="yloV CDS" gene 1489004..1490665 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /label="yloV gene" S_feature 1490666..1490755 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1490728..1490735 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1490749..1490768 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1490757 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="upshifts" CDS 1490804..1491466 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" /label="sdaAB CDS" gene 1490804..1491466 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /label="sdaAB gene" CDS 1491492..1492394 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" /label="sdaAA CDS" gene 1491492..1492394 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /label="sdaAA gene" CDS 1492372..1494420 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" /label="recG CDS" gene 1492372..1494420 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /label="recG gene" promotor_-35 1494456..1494463 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1494478..1494497 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1494484 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1494529..1495095 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" /label="fapR CDS" gene 1494529..1495095 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /label="fapR gene" CDS 1495109..1496110 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " /label="plsX CDS" gene 1495109..1496110 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /label="plsX gene" CDS 1496129..1497082 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" /label="fabD CDS" gene 1496129..1497082 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /label="fabD gene" CDS 1497075..1497815 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" /label="fabG CDS" gene 1497075..1497815 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /label="fabG gene" promotor_-35 1497846..1497850 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1497866..1497885 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1497871 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1497899..1498132 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" /label="acpA CDS" gene 1497899..1498132 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /label="acpA gene" downshifts 1498113 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" promotor_no_box 1498141..1498241 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1498201..1498271 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1498201 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1498272..1499021 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" /label="rnc CDS" gene 1498272..1499021 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /label="rnc gene" downshifts 1498993 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1499063..1499069 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1499081..1499100 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1499103 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1499122..1502682 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" /label="smc CDS" gene 1499122..1502682 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /label="smc gene" S_feature complement(1502616..1503686) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1502702..1503691 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" /label="ftsY CDS" gene 1502702..1503691 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /label="ftsY gene" downshifts 1503678 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1503728..1504213) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" /label="ylqB CDS" gene complement(1503728..1504213) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /label="ylqB gene" downshifts complement(1503731) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1504235..1504253) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1504251) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1504267..1504274) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1504316..1504322 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1504337..1504356 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1504339 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1504390..1504722 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" /label="ylxM CDS" gene 1504390..1504722 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /label="ylxM gene" downshifts complement(1504393) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" /label="downshifts" CDS 1504736..1506076 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" /label="ffh CDS" gene 1504736..1506076 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /label="ffh gene" S_feature 1506077..1506181 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1506182..1506454 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" /label="rpsP CDS" gene 1506182..1506454 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /label="rpsP gene" CDS 1506454..1506699 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" /label="ylqC CDS" gene 1506454..1506699 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /label="ylqC gene" downshifts 1506671 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" S_feature 1506716..1506820 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1506821..1507207 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" /label="ylqD CDS" gene 1506821..1507207 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /label="ylqD gene" CDS 1507212..1507736 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" /label="rimM CDS" gene 1507212..1507736 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /label="rimM gene" CDS 1507733..1508464 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" /label="trmD CDS" gene 1507733..1508464 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /label="trmD gene" promotor_-35 1508470..1508477 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1508491..1508510 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1508495 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" misc_RNA 1508543..1508584 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" /label="L19 leader RNA" gene 1508543..1508584 /locus_tag="BSU_misc_RNA_30" /label="gene" CDS 1508604..1508951 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" /label="rplS CDS" gene 1508604..1508951 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /label="rplS gene" downshifts 1508953 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" /label="downshifts" promotor_-35 1509006..1509012 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1509025..1509093 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1509025 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1509026..1509045 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1509094..1509942 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" /label="rbgA CDS" gene 1509094..1509942 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /label="rbgA gene" promotor_-35 1509963..1509970 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1509983..1510001 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1509993 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1510013..1510780 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" /label="rnhB CDS" gene 1510013..1510780 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /label="rnhB gene" CDS 1510812..1512542 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" /label="ylqG CDS" gene 1510812..1512542 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /label="ylqG gene" upshifts complement(1512049) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1512050..1512069) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1512084..1512091) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1512539..1512820 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" /label="ylqH CDS" gene 1512539..1512820 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /label="ylqH gene" downshifts 1512652 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" /label="downshifts" S_feature 1512821..1512940 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1512912..1512919 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1512933..1512952 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1512942 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1512993..1514150 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" /label="sucC CDS" gene 1512993..1514150 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /label="sucC gene" promotor_no_box complement(1513065..1513165) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1513105) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1514179..1515081 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" /label="sucD CDS" gene 1514179..1515081 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /label="sucD gene" downshifts 1515071 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" /label="downshifts" CDS 1515142..1516035 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" /label="dprA CDS" gene 1515142..1516035 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /label="dprA gene" promotor_-35 1516041..1516048 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1516063..1516082 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1516070..1516222 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1516070 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1516223..1518298 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" /label="topA CDS" gene 1516223..1518298 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /label="topA gene" downshifts 1518268 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 1518330..1518335 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1518342 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1518351..1518369 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1518374..1519681 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" /label="trmFO CDS" gene 1518374..1519681 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /label="trmFO gene" promotor_-35 1519687..1519691 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1519708..1519727 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1519718 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1519749..1520663 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" /label="codV CDS" gene 1519749..1520663 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /label="codV gene" promotor_-35 1519788..1519792 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1519805 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="upshifts" promotor_-10 1519808..1519827 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1520676..1521221 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" /label="clpQ CDS" gene 1520676..1521221 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /label="clpQ gene" CDS 1521238..1522641 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" /label="clpY CDS" gene 1521238..1522641 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /label="clpY gene" CDS 1522681..1523460 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" /label="codY CDS" gene 1522681..1523460 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /label="codY gene" downshifts 1523435 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1523479 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1523580..1523587 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1523600..1523618 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1523611..1523764 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1523611 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1523739..1523746 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1523761..1523780 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1523766 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1523840..1524229 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" /label="flgB CDS" gene 1523840..1524229 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /label="flgB gene" CDS 1524229..1524681 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" /label="flgC CDS" gene 1524229..1524681 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /label="flgC gene" SCAR 1524682..1524683 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_004" CDS 1524738..1525502 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" /label="sigD CDS" gene 1524738..1525502 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /label="sigD gene" promotor_-35 1525512..1525518 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1525531..1526034 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" /label="swrB CDS" gene 1525531..1526034 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /label="swrB gene" promotor_-10 1525533..1525544 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1525547 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1526030..1526036 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1526051..1526070 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1526053..1526177 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1526053 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1526178..1526918 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" /label="rpsB CDS" gene 1526178..1526918 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /label="rpsB gene" downshifts 1526900 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" /label="downshifts" S_feature 1526945..1527019 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1527020..1527901 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" /label="tsf CDS" gene 1527020..1527901 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /label="tsf gene" S_feature 1527902..1528046 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1528047..1528769 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" /label="pyrH CDS" gene 1528047..1528769 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /label="pyrH gene" CDS 1528771..1529328 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" /label="frr CDS" gene 1528771..1529328 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /label="frr gene" downshifts complement(1529275) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" /label="downshifts" promotor_-35 1529317..1529320 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1529335..1529354 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1529353..1529458 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1529353 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1529459..1530241 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" /label="uppS CDS" gene 1529459..1530241 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /label="uppS gene" CDS 1530245..1531054 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" /label="cdsA" gene 1530245..1531054 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /label="cdsA gene" promotor_-35 1531035..1531042 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1531057..1531076 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1531058 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1531116..1532267 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" /label="dxr CDS" gene 1531116..1532267 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /label="dxr gene" CDS 1532274..1533542 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" /label="rasP CDS" gene 1532274..1533542 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /label="rasP gene" CDS 1533575..1535269 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" /label="proS CDS" gene 1533575..1535269 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /label="proS gene" S_feature 1535270..1535377 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1535378..1539691 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" /label="polC CDS" gene 1535378..1539691 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /label="polC gene" S_feature 1539692..1539756 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1539702..1539919 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surG RNA" gene 1539702..1539919 /gene="surG" /locus_tag="BSU_misc_RNA_71" /label="surG gene" promotor_-35 1539728..1539734 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1539749..1539760 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1539758..1539825 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1539758 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="upshifts" promotor_-35 1539808..1539814 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1539827..1540020 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1539827 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="upshifts" promotor_-10 1539828..1539847 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1540021..1540491 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" /label="rimP CDS" gene 1540021..1540491 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /label="rimP gene" downshifts complement(1540342) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1540526..1541641 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" /label="nusA CDS" gene 1540526..1541641 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /label="nusA gene" promotor_no_box complement(1540588..1540688) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1540628) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1541655..1541930 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" /label="rulR CDS" gene 1541655..1541930 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /label="rulR gene" CDS 1541932..1542234 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" /label="rulQ CDS" gene 1541932..1542234 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /label="rulQ gene" CDS 1542254..1544404 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" /label="infB CDS" gene 1542254..1544404 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /label="infB gene" promotor_-35 1544299..1544305 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1544314 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1544320..1544338 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1544401..1544679 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" /label="ylxP CDS" gene 1544401..1544679 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo /label="ylxP gene" CDS 1544696..1545049 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" /label="rbfA CDS" gene 1544696..1545049 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /label="rbfA gene" downshifts 1545040 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" CDS 1545131..1546060 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" /label="truB CDS" gene 1545131..1546060 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /label="truB gene" promotor_-35 1545845..1545852 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1545866..1545885 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1545875 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1546079..1547029 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" /label="ribC CDS" gene 1546079..1547029 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /label="ribC gene" promotor_-35 1547062..1547068 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1547069..1547185 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1547069 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1547083..1547102 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1547186..1547455 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" /label="rpsO CDS" gene 1547186..1547455 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /label="rpsO gene" downshifts 1547438 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" S_feature 1547483..1547568 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1547549..1547552 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1547568..1547587 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1547570 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1547628..1549745 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" /label="pnpA CDS" gene 1547628..1549745 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /label="pnpA gene" downshifts 1549528 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 1549729 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature 1549774..1549862 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1549863..1550822 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" /label="ylxY CDS" gene 1549863..1550822 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /label="ylxY gene" promotor_-10 complement(1549931..1549939) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1549934) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1549953..1549960) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1550426..1550431 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1550447..1550465 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1550452 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1550862..1552091 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" /label="mlpA CDS" gene 1550862..1552091 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /label="mlpA gene" downshifts 1552080 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1552120..1552125 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1552135 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1552141..1552159 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1552169..1552426 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" /label="ymxH CDS" gene 1552169..1552426 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /label="ymxH gene" S_feature 1552427..1552481 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1552454 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1552523..1552532 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1552542..1552611 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1552542 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="upshifts" promotor_-10 1552546..1552565 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1552612..1553505 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" /label="spoVFA CDS" gene 1552612..1553505 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /label="spoVFA gene" CDS 1553508..1554110 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" /label="spoVFB CDS" gene 1553508..1554110 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /label="spoVFB gene" misc_feature 1554164..1554183 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1554164..1554235 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1554164 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1554236..1555276 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" /label="asd CDS" gene 1554236..1555276 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /label="asd gene" S_feature 1555277..1555367 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1555368..1556582 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" /label="dapG CDS" gene 1555368..1556582 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /label="dapG gene" CDS 1556613..1557485 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" /label="dapA CDS" gene 1556613..1557485 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /label="dapA gene" S_feature complement(1556956..1558140) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1557492 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1557585..1557588 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1557602 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1557604..1557623 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1557663..1559330 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" /label="rnjB CDS" gene 1557663..1559330 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /label="rnjB gene" promotor_-10 complement(1558127..1558145) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1558144) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1558161..1558166) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1559318 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1559385..1559391 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1559405..1559416 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1559406 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="upshifts" CDS 1559446..1560183 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" /label="tepA CDS" gene 1559446..1560183 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /label="tepA gene" CDS 1560180..1560392 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" /label="tepJ CDS" gene 1560180..1560392 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /label="tepJ gene" misc_feature 1560420..1560439 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1560434 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="upshifts" CDS 1560523..1562886 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" /label="spoIIIE CDS" gene 1560523..1562886 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /label="spoIIIE gene" S_feature 1562887..1562987 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1562948..1562955 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1562970..1562989 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1562988 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="upshifts" CDS 1563030..1563755 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" /label="ymfC CDS" gene 1563030..1563755 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /label="ymfC gene" downshifts 1563742 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 1563811..1563817 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1563830 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1563832..1563843 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1563894..1565102 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" /label="bcbE CDS" gene 1563894..1565102 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /label="bcbE gene" downshifts 1565060 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1565171..1565178 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1565191..1565210 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1565213 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" promotor_-35 1565225..1565228 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1565244..1565256 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1565258 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1565282..1566562 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" /label="ymfF CDS" gene 1565282..1566562 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /label="ymfF gene" CDS 1566559..1567845 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" /label="ymfH CDS" gene 1566559..1567845 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /label="ymfH gene" downshifts 1567695 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" /label="downshifts" S_feature 1567846..1567899 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1567900..1568628 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" /label="efpI CDS" gene 1567900..1568628 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /label="efpI gene" promotor_-35 1568644..1568650 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1568662 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1568664..1568675 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1568675) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1568686..1568700) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1568709..1568713) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1568709..1568966 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" /label="ymfJ CDS" gene 1568709..1568966 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /label="ymfJ gene" downshifts 1568951 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1568983) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" /label="downshifts" promotor_-35 1569024..1569027 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1569042..1569061 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1569042 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1569096..1569611 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" /label="ymfKn CDS" gene 1569096..1569611 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo /label="ymfKn gene" CDS 1569547..1569885 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" /label="ymfKc CDS" gene 1569547..1569885 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo /label="ymfKc gene" CDS 1569952..1570818 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" /label="rodZ CDS" gene 1569952..1570818 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /label="rodZ gene" promotor_no_box 1570015..1570115 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1570075 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" downshifts 1570778 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1570868..1571449 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" /label="pgsA CDS" gene 1570868..1571449 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /label="pgsA gene" CDS 1571467..1572717 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" /label="cinA CDS" gene 1571467..1572717 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /label="cinA gene" S_feature 1572718..1572844 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1572824..1572831 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1572846..1572865 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1572846 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1572890..1573936 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" /label="recA CDS" gene 1572890..1573936 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /label="recA gene" downshifts 1573948 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 1573993..1574058 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1574030..1574039 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1574052..1574067 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1574060 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1574104..1575279 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " /label="pbpX CDS" gene 1574104..1575279 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /label="pbpX gene" S_feature 1575280..1575379 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1575353..1575360 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1575374..1575393 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1575381..1575554 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1575381 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1575555..1577117 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" /label="rny CDS" gene 1575555..1577117 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /label="rny gene" downshifts 1577094 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" CDS 1577186..1577980 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" /label="pdeB CDS" gene 1577186..1577980 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /label="pdeB gene" promotor_-35 1577735..1577740 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1577756..1577774 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1577776 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="upshifts" promotor_-35 1578024..1578029 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1578040..1578179 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1578040 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="upshifts" promotor_-10 1578045..1578063 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1578072) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1578083..1578096) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1578105..1578109) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1578116) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" /label="downshifts" CDS 1578180..1578440 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" /label="spoVS CDS" gene 1578180..1578440 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /label="spoVS gene" downshifts 1578392 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts complement(1578424) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" /label="downshifts" downshifts 1578436 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1578481..1578655 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1578639..1578646 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1578657 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1578661..1578680 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1578706..1579749 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" /label="tdh CDS" gene 1578706..1579749 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /label="tdh gene" CDS 1579762..1580940 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" /label="kbl CDS" gene 1579762..1580940 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /label="kbl gene" downshifts 1580922 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" promotor_-35 1581020..1581023 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1581032 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1581038..1581057 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1581088..1582617 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" /label="miaB CDS" gene 1581088..1582617 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /label="miaB gene" CDS 1582619..1583050 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" /label="ricA CDS" gene 1582619..1583050 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /label="ricA gene" downshifts 1583033 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1583181..1583186 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1583202..1583220 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1583210..1583311 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1583210 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="upshifts" CDS 1583312..1583857 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" /label="cotE CDS" gene 1583312..1583857 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /label="cotE gene" downshifts 1583851 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" /label="downshifts" downshifts complement(1583858) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" /label="downshifts" promotor_-35 1583915..1583918 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1583933..1583952 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1583937 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="upshifts" CDS 1583990..1586566 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" /label="mutS CDS" gene 1583990..1586566 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /label="mutS gene" CDS 1586582..1588465 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" /label="mutL CDS" gene 1586582..1588465 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /label="mutL gene" S_feature complement(1588368..1588862) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S611" downshifts 1588380 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1588390) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1588612..1588619 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1588634..1588653 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1588644..1588777 /Source="Nicolas_S_feature" /locus_tag="new_1780399_1780532" /HighExp="LoTm, T0.30H, T1.30H, M9-stat, T3.0H, BC, T1.0H, B60, B36, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99494800000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S612" upshifts 1588644 /Source="Nicolas_upshifts" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1588649..1588799) /gene="surX" /locus_tag="BSU_misc_RNA_89" /product="small untranslated RNA of unknown function" /note="Evidence 5: Unknown function; PubMedId : 20525796, 23155385" /label="surX RNA" gene complement(1588649..1588799) /gene="surX" /locus_tag="BSU_misc_RNA_89" /label="surX gene" downshifts 1588734 /Source="Nicolas_upshifts" /id="D925" /incds=0 /nref=19 /ntot=136 /MaxReadThrough="3.45962" /MaxDrop="4.12444" /score="29.4045648" /energy="-15.3" /TU="U1365" /idTUdmin="U1364" /TUdmin=354 /isTUend="FALSE" /label="downshifts" CDS complement(1588863..1589318) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="YP_054578.1" /db_xref="EnsemblGenomes-Gn:BSU17060" /db_xref="EnsemblGenomes-Tr:CAE01453" /db_xref="GOA:Q7WY71" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14188" /db_xref="UniProtKB/Swiss-Prot:Q7WY71" /translation="MNQKEQNEHSKDFNLRSKLIGIVSITFIAAIALAVIFGGFFFGM KGLFSILGITYASNQTLALFILACFAVGLIIDPLTKIISIILAKSLSLKKTALFAFIL YFISNLITICFADYFMQSIYIPDVLLVVISAFMAIIELAFDNQPNREAA*" /label="ymzD CDS" gene complement(1588863..1589318) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /label="ymzD gene" S_feature complement(1589319..1589410) /Source="Nicolas_S_feature" /locus_tag="new_1781074_1781165_c" /HighExp="LBGstat, M9-stat, T1.0H, T1.30H, T2.0H, M0t90, MG 150, LPhT, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S613" promotor_-10 complement(1589398..1589417) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1589410) /Source="Nicolas_upshifts" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1589434..1589437) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1589473..1590030) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389588.1" /db_xref="EnsemblGenomes-Gn:BSU17070" /db_xref="EnsemblGenomes-Tr:CAB13579" /db_xref="GOA:O31780" /db_xref="SubtiList:BG13419" /db_xref="UniProtKB/Swiss-Prot:O31780" /translation="MNGIAWMIVFCEIAFWVVIVLGLAVRYVFKRHTLGLLFLALTPV IDLILLAATGVDLYRGASATAAHGIAAVYIGISIAYGKQMIQWADEKFQYYVTKKGTK PLKRFGMDHAKHGAKGWLRHVLAYLIGAGLLAGMIYFINDSSRTEALSGILKLWTVII GIDFLITASYFIWPKKEKASANLRS*" /label="ymcC CDS" gene complement(1589473..1590030) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /label="ymcC gene" SCAR 1590121..1590122 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs08" downshifts complement(1590173) /Source="Nicolas_upshifts" /id="D929" /incds=0 /nref=24 /ntot=184 /MaxReadThrough="3.69744" /MaxDrop="5.18486" /score="-0.71313204" /energy="-20.1" /TU="U1374" /idTUdmin="U1375" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(1590179..1590535) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11544224, 15805528, 20817675" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function involved in ethanol resistance" /protein_id="NP_389606.3" /db_xref="EnsemblGenomes-Gn:BSU17240" /db_xref="EnsemblGenomes-Tr:CAB13608" /db_xref="SubtiList:BG13435" /db_xref="UniProtKB/Swiss-Prot:O31786" /translation="MAHTNTQLSQWLESKVGQTLDIRKGELTHDEEISDLDQIVLHLQ KVAIRSTNHPDDYVAKEELVLEGEGTTFTEDGNVPLPQNAYEIPLLGELHIHQENEGL KVVTDRAVYTIDIQHS*" /label="ymzB CDS" gene complement(1590179..1590535) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /label="ymzB gene" misc_feature complement(1590595..1590608) /Source="Nicolas_upshift_promotors" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1590600) /Source="Nicolas_upshifts" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1590614..1591438) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20817675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389607.2" /db_xref="EnsemblGenomes-Gn:BSU17250" /db_xref="EnsemblGenomes-Tr:CAB13609" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13413" /db_xref="UniProtKB/Swiss-Prot:O31787" /translation="MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLE DMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTID QINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETL NMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLI PLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT*" /label="ymaE CDS" gene complement(1590614..1591438) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /label="ymaE gene" promotor_-10 complement(1591460..1591479) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1591476) /Source="Nicolas_upshifts" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1591491..1591497) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1591549..1592877) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10589719, 16267290, 17884659, 28693413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10589719, 16267290, 17884659, 28693413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline serine protease" /protein_id="NP_389608.1" /db_xref="EnsemblGenomes-Gn:BSU17260" /db_xref="EnsemblGenomes-Tr:CAB13610" /db_xref="GOA:O31788" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG12567" /db_xref="UniProtKB/Swiss-Prot:O31788" /translation="MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFE TKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSAL HSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYP HPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGV KVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRA VEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSS RGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAG IAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ*" /label="aprX CDS" gene complement(1591549..1592877) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /label="aprX gene" downshifts complement(1591556) /Source="Nicolas_upshifts" /id="D930" /incds=0 /nref=13 /ntot=21 /MaxReadThrough="2.43809" /MaxDrop="5.8915" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1376" /TUdmin=8 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1592900..1592919) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1592919) /Source="Nicolas_upshifts" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1592933..1592941) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1593034..1593041 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1593049..1593068) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1593057..1593076 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1593060) /Source="Nicolas_upshifts" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" upshifts 1593063 /Source="Nicolas_upshifts" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1593081..1593088) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1593102..1593179 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of YmzE" /translation="MNFYLHRSLESQMPISIIYEERRND*" /label="ymzEn CDS" gene 1593102..1593179 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /pseudo /label="ymzEn gene" downshifts complement(1593104) /Source="Nicolas_upshifts" /id="D931" /incds=0 /nref=4 /ntot=7 /MaxReadThrough="1.51659" /MaxDrop="5.37668" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1377" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS 1593157..1593333 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of YmzE" /db_xref="PSEUDO:CAX52622.1" /translation="MKKDGTISKRTIIVRQKSKTKIKAFCFSKQQIRTFLLDSILSCD FVRTNKQNLYSAGR*" /label="ymzEc CDS" gene 1593157..1593333 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /pseudo /label="ymzEc gene" downshifts 1593314 /Source="Nicolas_upshifts" /id="D932" /incds=0 /nref=42 /ntot=207 /MaxReadThrough="4.03151" /MaxDrop="6.55778" /score="-0.929304655" /energy="-5.5" /TU="U1378" /idTUdmin="U1378" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature 1593359..1593547 /Source="Nicolas_S_feature" /locus_tag="new_1863194_1863382" /HighExp="H2O2, M40t90, C90, M40t45, C30, S8, HiOs, G135, T-4.40H, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S619" misc_feature 1593542..1593561 /Source="Nicolas_upshift_promotors" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1593549 /Source="Nicolas_upshifts" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1593613..1594320 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16267290, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="gamma-polyglutamate hydrolase (phage origin)" /protein_id="NP_389609.1" /db_xref="EnsemblGenomes-Gn:BSU17270" /db_xref="EnsemblGenomes-Tr:CAB13611" /db_xref="GOA:O31789" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13411" /db_xref="UniProtKB/Swiss-Prot:O31789" /translation="MRRFLLNVILVLAIVLFLRYVHYSLEPEPSNQPDTYSNFSSLAE NESPADYDISYNEKKGSKVLIMSPHGGRIEGGVSELVRYFNNEYSTYLFEGLKSHDNQ TLHITSTNFDEPLAKKKIKEHQYVVAFHGYKGENKNTLVGGTDRKRAKMIVRALERRG FSAELASSKSGLAGLNAENINNQGETGLSIQLEISREQREAFFDDFYYKNRKYTKNSE FYAYVSAIKGVLEKEYS*" /label="pghC CDS" gene 1593613..1594320 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /label="pghC gene" promotor_-35 1594331..1594337 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1594351..1594370 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1594355 /Source="Nicolas_upshifts" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1594390..1594842 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290, 22904090, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peroxiredoxin-related protein" /protein_id="NP_389610.1" /db_xref="EnsemblGenomes-Gn:BSU17280" /db_xref="EnsemblGenomes-Tr:CAB13612" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019905" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13412" /db_xref="UniProtKB/Swiss-Prot:O31790" /translation="MADHHFYLKANWPGNRNDVGTIESGNLITSISIPKEMDGPGEGT NPDEMLLGAAATCYIITLAAMMERSGLEKEDLQMESEGIVNVTKGVFTYKKIIHRPSV VLKHDASQDDVALAHKLCKKAESSCMISRAIQGNVELQLEASVKLGGE*" /label="ymaD CDS" gene 1594390..1594842 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /label="ymaD gene" downshifts 1594830 /Source="Nicolas_upshifts" /id="D933" /incds=0 /nref=44 /ntot=182 /MaxReadThrough="1.35366" /MaxDrop="6.07534" /score="17.0193804" /energy="-12.1" /TU="NA" /idTUdmin="U1379" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1594856..1595209) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 15849754, 16750162, 16850406, 18024586, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 15849754, 16750162, 16850406, 18024586, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389611.1" /db_xref="EnsemblGenomes-Gn:BSU17290" /db_xref="EnsemblGenomes-Tr:CAB13613" /db_xref="GOA:P0CW82" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12586" /db_xref="UniProtKB/Swiss-Prot:P0CW82" /translation="MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAF TFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLN QSKAHAEDKKQTACE*" /label="ebrB CDS" gene complement(1594856..1595209) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /label="ebrB gene" downshifts complement(1594897) /Source="Nicolas_upshifts" /id="D934" /incds=0 /nref=2 /ntot=45 /MaxReadThrough="0.84905" /MaxDrop="2.87924" /score="-2.89884673" /energy="-8.7" /TU="NA" /idTUdmin="U1381" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1595223..1595540) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 11104814, 17516673, 18024586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 11104814, 17516673, 18024586; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389612.1" /db_xref="EnsemblGenomes-Gn:BSU17300" /db_xref="EnsemblGenomes-Tr:CAB13614" /db_xref="GOA:P0CW80" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12585" /db_xref="UniProtKB/Swiss-Prot:P0CW80" /translation="MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLA FYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLL NWP*" /label="ebrA CDS" gene complement(1595223..1595540) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /label="ebrA gene" promotor_-10 complement(1595584..1595603) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1595592) /Source="Nicolas_upshifts" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1595618..1595625) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1595677..1595952) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAPFPFYY*" /label="ymaG CDS" gene complement(1595677..1595952) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /label="ymaG gene" downshifts complement(1595678) /Source="Nicolas_upshifts" /id="D935" /incds=0 /nref=38 /ntot=44 /MaxReadThrough="0.28059" /MaxDrop="8.33353" /score="12.3408391" /energy="-11.5" /TU="NA" /idTUdmin="U1383" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1595948..1595953 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1595969..1595987 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1595979..1595998) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1595989 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="upshifts" upshifts complement(1595992) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1596011..1596020) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1596041..1596454 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" /label="ymaF CDS" gene 1596041..1596454 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /label="ymaF gene" upshifts 1596505 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="upshifts" misc_feature 1596511..1596530 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1596554..1597498 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" /label="miaA CDS" gene 1596554..1597498 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /label="miaA gene" promotor_-35 1597478..1597486 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1597497..1597515 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1597499 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="upshifts" CDS 1597538..1597759 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" /label="hfq CDS" gene 1597538..1597759 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /label="hfq gene" downshifts complement(1597549) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1597611..1597615) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1597615) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1597630..1597635) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1597759 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1597955..1598227 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" /label="ymzC CDS" gene 1597955..1598227 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /label="ymzC gene" promotor_-35 1598243..1598250 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1598264..1598283 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1598266 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="upshifts" CDS 1598309..1598539 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" /label="ymzA CDS" gene 1598309..1598539 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /label="ymzA gene" S_feature 1598540..1598616 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1598573 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 1598618..1598725 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1598698..1598705 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1598719..1598738 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1598727 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="upshifts" CDS 1598782..1599174 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" /label="nrdI CDS" gene 1598782..1599174 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /label="nrdI gene" CDS 1599134..1601236 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" /label="nrdE CDS" gene 1599134..1601236 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /label="nrdE gene" CDS 1601254..1602243 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" /label="nrdF CDS" gene 1601254..1602243 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /label="nrdF gene" downshifts 1602203 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(1602257..1602916) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1602272) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 1602293..1602913 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" /label="ymaB CDS" gene 1602293..1602913 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /label="ymaB gene" downshifts 1602894 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" /label="downshifts" promotor_-35 1602929..1602933 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1602951..1603318 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1602951 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1602955..1602972 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1602961) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS complement(1602977..1603744) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" /label="cwlC CDS" gene complement(1602977..1603744) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /label="cwlC gene" promotor_-10 complement(1603753..1603772) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1603776) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1603785..1603794) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1603898..1603903 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1603919..1603937 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1603919 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1604201..1604206 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1604223..1604241 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1604227..1604367 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1604227 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="upshifts" CDS 1604368..1605336 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" /label="spoVK CDS" gene 1604368..1605336 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /label="spoVK gene" downshifts 1605305 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-35 1605400..1605408 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1605415 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="upshifts" promotor_-10 1605419..1605438 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1605469..1606731 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" /label="hflX CDS" gene 1605469..1606731 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /label="hflX gene" CDS 1606749..1608014 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" /label="ynbB CDS" gene 1606749..1608014 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /label="ynbB gene" promotor_-35 1608062..1608069 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1608084..1608103 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1608096 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="upshifts" CDS 1608124..1608531 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" /label="glnR CDS" gene 1608124..1608531 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /label="glnR gene" downshifts complement(1608130) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" /label="downshifts" misc_feature 1608512..1608530 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1608537 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1608590) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" /label="downshifts" CDS 1608590..1609924 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" /label="glnA CDS" gene 1608590..1609924 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /label="glnA gene" downshifts 1609901 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature 1609946..>1609995 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" SCAR 1609995..1609996 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs04" S_feature <1609996..1610748 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1610088..1610106) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1610106) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1610122..1610127) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1610749..1612140 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" /label="xynP CDS" gene 1610749..1612140 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /label="xynP gene" CDS 1612171..1613772 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" /label="xynB CDS" gene 1612171..1613772 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /label="xynB gene" S_feature complement(1612287..1612592) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1612587..1612606) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1612592) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1612620..1612628) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1613770 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" /label="downshifts" CDS complement(1613909..1615063) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" /label="xylR CDS" gene complement(1613909..1615063) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /label="xylR gene" downshifts complement(1613912) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1614962..1615140) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1615108..1615114 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1615123..1615142) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1615124..1615140 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1615134 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1615140) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1615157..1615160) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1615167..1615174 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1615189..1615208 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1615200..1615304 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1615201 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="upshifts" CDS 1615305..1616642 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" /label="xylA CDS" gene 1615305..1616642 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /label="xylA gene" S_feature 1616643..1616717 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1616674 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" CDS 1616793..1618292 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" /label="xylB CDS" gene 1616793..1618292 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /label="xylB gene" S_feature 1618293..1618608 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1618566 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1618775..1619410) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" /label="yncB CDS" gene complement(1618775..1619410) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /label="yncB gene" promotor_-10 complement(1619447..1619466) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1619456) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1619481..1619488) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1619598..1619605 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1619620..1619639 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1619622..1619820 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1619622 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="upshifts" CDS 1619821..1621236 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" /label="yncC CDS" gene 1619821..1621236 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /label="yncC gene" downshifts 1621226 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1621329) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1621338..1622522) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" /label="alrB CDS" gene complement(1621338..1622522) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /label="alrB gene" S_feature complement(1622523..1622602) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1622595..1622613) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1622606) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1622629..1622634) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1622914..1622921 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1622936..1622955 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1622944 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1622986..1623447 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" /label="yncE CDS" gene 1622986..1623447 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /label="yncE gene" CDS 1623477..1623911 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" /label="dutA CDS" gene 1623477..1623911 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /label="dutA gene" S_feature complement(1623660..1623965) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1623758 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" S_feature 1623912..1625008 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1623967..1624252) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1624010) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1624247..1624266) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1624252) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1624278..1624283) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1624514) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1624514..1624774) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" /label="cotU CDS" gene complement(1624514..1624774) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /label="cotU gene" promotor_-10 complement(1624795..1624814) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1624805) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1624827..1624836) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1625009..1625134 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" /label="ynzJ CDS" gene 1625009..1625134 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo /label="ynzJ gene" S_feature 1625135..1625251 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1625178..1625342 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" /label="conserved hypothetical protein from phage origin CDS" gene 1625178..1625342 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /label="gene" promotor_-35 1625226..1625235 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1625249..1625268 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1625253..1625563 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1625253 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1625544..1625551 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1625565..1625584 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1625565 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1625616..1626455 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" /label="thyA CDS" gene 1625616..1626455 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /label="thyA gene" promotor_-10 complement(1625638..1625657) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1625659) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1625672..1625675) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1626415 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts complement(1626561) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature complement(1626562..1626868) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1626578..1626865) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" /label="conserved protein of unknown function CDS" gene complement(1626578..1626865) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /label="gene" downshifts complement(1626605) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1626692..1626700 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1626714..1626733 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1626716 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="upshifts" S_feature 1626727..1626887 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1626859 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1626908..1627630) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" /label="yncM CDS" gene complement(1626908..1627630) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /label="yncM gene" downshifts complement(1626913) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1627655..1627674) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1627663) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1627665..1627789) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1627790..1628146) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" /label="ynzK CDS" gene complement(1627790..1628146) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /label="ynzK gene" promotor_-10 complement(1628170..1628189) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1628187) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1628205..1628209) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1628386) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1628392..1628592) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" /label="cotC CDS" gene complement(1628392..1628592) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /label="cotC gene" downshifts 1628575 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1628614..1628633) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1628626) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1628646..1628655) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1628767..1628955) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" /label="tatAC CDS" gene complement(1628767..1628955) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /label="tatAC gene" downshifts complement(1628783) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" misc_feature complement(1628924..1628931) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1628937) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1628984..1629003) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1629002) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1629018..1629025) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1629034..1629171 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" /label="hypothetical protein CDS" gene 1629034..1629171 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /label="gene" promotor_-35 1629065..1629070 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1629085..1629103 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1629103..1629205 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1629103 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="upshifts" CDS 1629206..1629604 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" /label="yndA CDS" gene 1629206..1629604 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /label="yndA gene" S_feature 1629605..1630409 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1629669..1630103) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" /label="flvS CDS" gene complement(1629669..1630103) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /label="flvS gene" downshifts complement(1629685) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1630133..1630152) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1630149) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1630166..1630173) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1630410..1630598 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" /label="ynzB CDS" gene 1630410..1630598 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /label="ynzB gene" S_feature 1630599..1630684 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1630643 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1630713..1630719 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1630731..1630890 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1630731 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1630733..1630744 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1630891..1632453 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" /label="yndD CDS" gene 1630891..1632453 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /label="yndD gene" promotor_-10 complement(1631194..1631213) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1631203) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1631228..1631235) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1632483..1633574 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" /label="yndE CDS" gene 1632483..1633574 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /label="yndE gene" CDS 1633564..1634778 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" /label="yndF CDS" gene 1633564..1634778 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /label="yndF gene" promotor_-35 1634856..1634863 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1634878..1634897 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1634889 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="upshifts" CDS 1634925..1635731 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" /label="yndG CDS" gene 1634925..1635731 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /label="yndG gene" S_feature complement(1635539..1636637) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1635736..1636353 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" /label="yndH CDS" gene 1635736..1636353 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /label="yndH gene" CDS 1636350..1637990 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" /label="yndJ CDS" gene 1636350..1637990 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /label="yndJ gene" promotor_-10 complement(1636624..1636643) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1636637) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1636657..1636665) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1637630..1638396) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1638027..1638392 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" /label="yndK CDS" gene 1638027..1638392 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /label="yndK gene" downshifts 1638369 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1638389..1638669) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surA RNA" gene complement(1638389..1638669) /gene="surA" /locus_tag="BSU_misc_RNA_72" /label="surA gene" S_feature complement(1638398..1638529) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1638441) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1638489..1638498 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1638511..1638520) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1638512..1638531 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1638517 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" S_feature 1638519..1638617 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1638529) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1638531..1638661) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1638618..1639376 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" /label="pghL CDS" gene 1638618..1639376 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /label="pghL gene" upshifts 1638651 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1638667..1638686) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1638668) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1638701..1638708) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1639191..1639402) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1639355 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" S_feature 1639400..1640019 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1639403..1639942) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" /label="yndM CDS" gene complement(1639403..1639942) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /label="yndM gene" promotor_-10 complement(1639943..1639957) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1639949) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1639971..1639977) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1639997..1640006 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1640019..1640034 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1640021 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" CDS 1640060..1640494 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" /label="fosB CDS" gene 1640060..1640494 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /label="fosB gene" CDS 1640352..1640699 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" /label="yzzP CDS" gene 1640352..1640699 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /label="yzzP gene" S_feature 1640495..1640827 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1640786..1640795 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1640807..1640822 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1640829..1641007 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1640829 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1640898..1640977 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="ncrF RNA" gene 1640898..1640977 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /label="ncrF gene" downshifts 1640964 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1641036..1641653) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" /label="lexA CDS" gene complement(1641036..1641653) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /label="lexA gene" downshifts complement(1641037) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1641677..1641696) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1641698) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1641710..1641717) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1641733..1641740 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1641752 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1641754..1641773 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1641803..1642120 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" /label="dinK CDS" gene 1641803..1642120 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /label="dinK gene" promotor_-10 complement(1641820..1641838) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1641823) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1641852..1641859) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1642139..1642792 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " /label="dinL CDS" gene 1642139..1642792 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /label="dinL gene" promotor_-35 1642795..1642802 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1642816..1642835 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1642829 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="upshifts" CDS 1642856..1643089 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" /label="ynzC CDS" gene 1642856..1643089 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /label="ynzC gene" S_feature 1643090..1643225 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1643193..1643200 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1643214..1643233 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1643227 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="upshifts" CDS 1643258..1645261 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" /label="tktA CDS" gene 1643258..1645261 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /label="tktA gene" misc_feature complement(1643462..1643481) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1643479) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1645251 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1645263..1645921) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1645361 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="upshifts" misc_feature 1645362..1645381 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1645414..1645860 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" /label="pcfA CDS" gene 1645414..1645860 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /label="pcfA gene" misc_feature 1645884..1645903 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1645892 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1645903..1645920) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1645921) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1645939..1645943) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1645946..1646164 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" /label="yneF CDS" gene 1645946..1646164 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /label="yneF gene" downshifts 1646176 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" /label="downshifts" S_feature 1646221..1646520 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1646238..1646411) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" /label="spo0D CDS" gene complement(1646238..1646411) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /label="spo0D gene" downshifts complement(1646251) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1646449..1646468) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1646456) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1646482..1646489) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1646491..1646499 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1646511..1646530) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1646511..1646529 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1646522..1646630 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1646522 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1646523) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1646545..1646552) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1646631..1647338 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" /label="ccdA CDS" gene 1646631..1647338 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /label="ccdA gene" promotor_-35 1647358..1647365 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1647377..1647396 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1647385 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1647427..1647789 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" /label="yneI CDS" gene 1647427..1647789 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /label="yneI gene" promotor_-35 1647807..1647810 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1647825..1647844 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1647836 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1647868..1648359 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" /label="yneJ CDS" gene 1647868..1648359 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /label="yneJ gene" downshifts 1648355 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1648390..1648818) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" /label="yneK CDS" gene complement(1648390..1648818) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /label="yneK gene" downshifts complement(1648407) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1648836..1648855) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1648848) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1648850..1648935) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1648869..1648876) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1648906..1648915 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1648925..1649034 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1648925 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1648928..1648947 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1648930..1648949) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1648935) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1648937..1649020) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1648964..1648967) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1648991 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1649052..1649444) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" /label="cotM CDS" gene complement(1649052..1649444) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /label="cotM gene" downshifts complement(1649065) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" /label="downshifts" promotor_-35 1649287..1649292 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1649308..1649326 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1649312 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="upshifts" promotor_-35 1649422..1649426 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1649436..1649450 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1649451..1649470) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1649453 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1649466) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1649484..1649493) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1649525..1649671) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" /label="sspP CDS" gene complement(1649525..1649671) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /label="sspP gene" downshifts complement(1649546) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1649703..1649849) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" /label="sspO CDS" gene complement(1649703..1649849) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /label="sspO gene" S_feature 1649849..1649982 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1649849 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1649860..1649862 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1649865..1649876) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1649879) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1649891..1649897) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1649972..1649979 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1649984..1650076 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1649984 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1649994..1650013 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1650035) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1650077..1652806 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" /label="citB CDS" gene 1650077..1652806 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /label="citB gene" misc_feature complement(1650097..1650101) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1650101) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1652807..1652877 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1652878..1653390 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" /label="yneN CDS" gene 1652878..1653390 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /label="yneN gene" downshifts 1653347 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-35 1653416..1653422 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1653435 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1653437..1653448 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1653471..1653596 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" /label="ynzL CDS" gene 1653471..1653596 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /label="ynzL gene" downshifts complement(1653489) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" /label="downshifts" promotor_-35 1653610..1653616 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1653631..1653642 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1653633 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" CDS 1653661..1653807 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" /label="sspN CDS" gene 1653661..1653807 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /label="sspN gene" CDS 1653844..1654095 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" /label="sspT CDS" gene 1653844..1654095 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /label="sspT gene" downshifts 1654073 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1654116..1654121 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1654135..1654154 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1654139..1654230 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1654139 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1654231..1654596 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" /label="yneP CDS" gene 1654231..1654596 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /label="yneP gene" CDS 1654612..1654911 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" /label="yneQ CDS" gene 1654612..1654911 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /label="yneQ gene" downshifts 1654887 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1654942..1655229) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" /label="yneR CDS" gene complement(1654942..1655229) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /label="yneR gene" downshifts complement(1654963) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(1655029) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1655259..1655278) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1655271) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1655294..1655301) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1655317..1655898) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" /label="plsY CDS" gene complement(1655317..1655898) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /label="plsY gene" S_feature 1655899..1656029 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1655924..1655943) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1655941) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1656014..1656017 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1656031 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1656033..1656052 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1656068..1656475 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" /label="yneT CDS" gene 1656068..1656475 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /label="yneT gene" downshifts 1656471 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" /label="downshifts" promotor_-35 1656537..1656540 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1656555..1656574 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1656559..1656873 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1656559 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" CDS 1656874..1658841 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" /label="parE CDS" gene 1656874..1658841 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /label="parE gene" CDS 1658845..1661265 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" /label="parC CDS" gene 1658845..1661265 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /label="parC gene" downshifts 1661245 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1661273..1661462) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1661312..1661488) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" /label="ynfCc CDS" gene complement(1661312..1661488) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo /label="ynfCc gene" downshifts complement(1661316) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1661463..1661873) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" /label="ynfCn CDS" gene complement(1661463..1661873) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo /label="ynfCn gene" promotor_-10 complement(1661846..1661865) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1661849) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1661880..1661887) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1661914..1661933) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1661915) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1661948..1661955) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1661962..1661981) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1661973) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1661995..1662004) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1662221..1662226 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1662239..1662258 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1662244 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="upshifts" S_feature 1662257..1662321 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1662322..1663719 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" /label="alsT CDS" gene 1662322..1663719 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /label="alsT gene" downshifts 1663708 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 1663753 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(1663809..1664555) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1663932..1663939 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1663951 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1663952..1663971 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1664022..1665521 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" /label="eglS CDS" gene 1664022..1665521 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /label="eglS gene" promotor_-10 complement(1664554..1664573) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1664577) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1664587..1664596) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1665469 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1665589..1665852 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" /label="ynfE CDS" gene 1665589..1665852 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /label="ynfE gene" downshifts complement(1666111) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1666111..1667379) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" /label="xynC CDS" gene complement(1666111..1667379) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /label="xynC gene" S_feature complement(1667380..1667509) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1667510..1669051) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" /label="xynD CDS" gene complement(1667510..1669051) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /label="xynD gene" S_feature complement(1669052..1669373) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1669363..1669382) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1669374) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1669397..1669400) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1669600..1669607 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1669620..1669639 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1669627 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1669646..1670092 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" /label="yngA CDS" gene 1669646..1670092 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /label="yngA gene" CDS 1670099..1670992 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" /label="yngB CDS" gene 1670099..1670992 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /label="yngB gene" misc_feature 1670609..1670628 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1670617 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="upshifts" CDS 1671065..1671661 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" /label="yngC CDS" gene 1671065..1671661 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /label="yngC gene" downshifts 1671651 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1671710..1672909) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" /label="nrnB CDS" gene complement(1671710..1672909) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /label="nrnB gene" S_feature complement(1672910..1672981) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1672969..1672980) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1672981) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1672995..1673001) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1673079..1674614) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" /label="ldeE CDS" gene complement(1673079..1674614) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /label="ldeE gene" downshifts complement(1673091) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1674625..1675407) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" /label="ldeF CDS" gene complement(1674625..1675407) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /label="ldeF gene" CDS complement(1675428..1676327) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" /label="ldeG CDS" gene complement(1675428..1676327) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /label="ldeG gene" CDS complement(1676342..1676563) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" /label="lgeHB CDS" gene complement(1676342..1676563) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /label="lgeHB gene" CDS complement(1676578..1677912) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" /label="ldeHA CDS" gene complement(1676578..1677912) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /label="ldeHA gene" CDS complement(1677922..1679571) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" /label="ldeI CDS" gene complement(1677922..1679571) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /label="ldeI gene" promotor_no_box 1677971..1678071 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1678031 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1679615..1680757) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" /label="ldeJ CDS" gene complement(1679615..1680757) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /label="ldeJ gene" promotor_-10 complement(1680776..1680794) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1680793) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1680810..1680815) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1680848..1681153) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " /label="ynzE CDS" gene complement(1680848..1681153) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /label="ynzE gene" CDS complement(1681143..1681316) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" /label="conserved protein of unknown function CDS" gene complement(1681143..1681316) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /label="gene" CDS complement(1681424..1682956) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" /label="yngK CDS" gene complement(1681424..1682956) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /label="yngK gene" downshifts complement(1681435) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1682991..1683010) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1682991) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1683023..1683032) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1683092..1683484) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" /label="yngL CDS" gene complement(1683092..1683484) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /label="yngL gene" downshifts complement(1683123) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1683512..1683523) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1683519) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1683537..1683543) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1683591,1683598) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs10" N_region 1683592..1683597 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs10" S_feature complement(<1683598..1683703) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1683688..1683707) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1683703) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1683721..1683728) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1683977..1685452) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" /label="dacC CDS" gene complement(1683977..1685452) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /label="dacC gene" downshifts complement(1683989) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(1685486..1686463) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" /label="galM CDS" gene complement(1685486..1686463) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /label="galM gene" promotor_-10 complement(1686492..1686510) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1686504) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1686522..1686530) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1686597..1687988) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" /label="yoeA CDS" gene complement(1686597..1687988) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /label="yoeA gene" downshifts complement(1686611) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" /label="downshifts" downshifts 1686757 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" promotor_-35 1687778..1687784 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1687798..1687816 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1687809..1688142 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1687809 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="upshifts" S_feature complement(1687989..1688093) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1688053..1688153) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1688093) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1688115..1688120 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1688136..1688154 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1688144 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1688202..1688209 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1688222..1688241 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1688225 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" CDS 1688274..1688819 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" /label="iseA CDS" gene 1688274..1688819 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /label="iseA gene" downshifts 1688803 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA complement(1688913..1688985) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg1 tRNA" gene complement(1688913..1688985) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /label="trnSL-Arg1 gene" downshifts complement(1689011) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1689038..1689583) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" /label="yoeC CDS" gene complement(1689038..1689583) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /label="yoeC gene" promotor_-10 complement(1689623..1689642) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1689637) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1689656..1689663) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1689899..1690129) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" /label="yoeD CDS" gene complement(1689899..1690129) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /label="yoeD gene" downshifts complement(1689913) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1690155..1690174) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1690167) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1690186..1690192) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1690221..1690240) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1690231) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1690244..1690251 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1690265..1690284 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1690269 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="upshifts" CDS 1690314..1692077 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" /label="ggt CDS" gene 1690314..1692077 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /label="ggt gene" downshifts 1692058 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1692178..1693035) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" /label="ftsR CDS" gene complement(1692178..1693035) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /label="ftsR gene" promotor_-10 complement(1693081..1693100) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1693101) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1693114..1693121) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1693163..1694152 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" /label="yogA CDS" gene 1693163..1694152 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /label="yogA gene" S_feature complement(1693219..1694177) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1694209..1695690) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" /label="gltB CDS" gene complement(1694209..1695690) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /label="gltB gene" downshifts complement(1694222) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" /label="downshifts" CDS complement(1695707..1700269) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" /label="gltA CDS" gene complement(1695707..1700269) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /label="gltA gene" promotor_no_box 1698730..1698830 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1698790 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1700270..1700341) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1700321..1700340) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1700338..1700345 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1700341) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1700355..1700362) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1700357 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1700360..1700379 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1700416..1701318 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" /label="gltC CDS" gene 1700416..1701318 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /label="gltC gene" downshifts 1701298 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1701370..1702485) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" /label="proJ CDS" gene complement(1701370..1702485) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /label="proJ gene" CDS complement(1702482..1703375) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" /label="proH CDS" gene complement(1702482..1703375) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /label="proH gene" promotor_-10 complement(1703380..1703399) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1703388 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" upshifts complement(1703398) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1703413..1703419) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1703428..1703446) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1703446) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1703462..1703467) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1703523..1703891) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" /label="rtp CDS" gene complement(1703523..1703891) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /label="rtp gene" promotor_-10 complement(1703926..1703944) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1703949) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="upshifts" S_feature complement(1703951..1704070) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1703956..1703964) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1704062..1704081) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1704070) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1704072..1704168) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1704096..1704103) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1704191..1704907) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" /label="yoxD CDS" gene complement(1704191..1704907) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /label="yoxD gene" downshifts complement(1704213) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1704945..1704964) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1704954) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1704980..1704983) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1705008..1705014 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1705028..1705046 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1705033 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="upshifts" CDS 1705058..1705363 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " /label="yoxC CDS" gene 1705058..1705363 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /label="yoxC gene" downshifts 1705347 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" /label="downshifts" CDS 1705434..1706204 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" /label="yoxB CDS" gene 1705434..1706204 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /label="yoxB gene" promotor_-35 1706186..1706193 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1706205 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1706208..1706227 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1706248..1706781 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" /label="yoaA CDS" gene 1706248..1706781 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /label="yoaA gene" S_feature 1706782..1706867 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1706824 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1706860..1708104) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" /label="yoaB CDS" gene complement(1706860..1708104) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /label="yoaB gene" S_feature 1706869..1707608 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1706874) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1708105..1708197) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1708198..1709661) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" /label="yoaC CDS" gene complement(1708198..1709661) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /label="yoaC gene" CDS complement(1709679..1710713) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" /label="yoaD CDS" gene complement(1709679..1710713) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /label="yoaD gene" S_feature complement(1710725..1710796) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1710768) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1710797..1710888) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswF RNA" gene complement(1710797..1710888) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /label="mswF gene" promotor_-10 complement(1710916..1710935) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1710928) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1710950..1710957) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1710970..1710977 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1710991..1711010 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1710995 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="upshifts" CDS 1711037..1713079 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" /label="yoaE CDS" gene 1711037..1713079 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /label="yoaE gene" promotor_-35 1713087..1713096 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1713109..1713124 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1713112 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1713146..1713439 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" /label="yoaF CDS" gene 1713146..1713439 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /label="yoaF gene" downshifts 1713419 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1713464..1713811) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1713495) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1713812..1714216) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" /label="yoaG CDS" gene complement(1713812..1714216) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /label="yoaG gene" S_feature complement(1714217..1714312) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1714302..1714317) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1714302..1714421) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" /label="hypothetical protein CDS" gene complement(1714302..1714421) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /label="gene" upshifts complement(1714312) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1714330..1714339) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1714417..1714423 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1714437..1714448 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1714448..1714656 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1714448 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1714491..1714613 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" /label="conserved hypothetical protein CDS" gene 1714491..1714613 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /label="gene" CDS 1714657..1714950 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" /label="yozQ CDS" gene 1714657..1714950 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /label="yozQ gene" S_feature 1714951..1715044 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1715001 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1715066..1716751) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" /label="yoaH CDS" gene complement(1715066..1716751) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /label="yoaH gene" downshifts complement(1715078) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(1716752..1716839) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1716831..1716849) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1716839) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1716863..1716870) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1717008..1717017 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1717027 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1717030..1717049 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1717076..1718527 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" /label="yoaI CDS" gene 1717076..1718527 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /label="yoaI gene" downshifts 1718503 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1718564..1719262) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" /label="exlX CDS" gene complement(1718564..1719262) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /label="exlX gene" downshifts complement(1718579) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1719297..1719316) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1719316) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1719318..1719531) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1719330..1719337) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1719532..1720209) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" /label="yoaK CDS" gene complement(1719532..1720209) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /label="yoaK gene" S_feature complement(1720210..1722699) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1720382..1721419 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" /label="pelB CDS" gene 1720382..1721419 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /label="pelB gene" promotor_-35 1721616..1721622 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1721637..1721648 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1721649 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1721676..1722359 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" /label="yoaM CDS" gene 1721676..1722359 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /label="yoaM gene" CDS complement(1722700..1723005) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " /label="yozS CDS" gene complement(1722700..1723005) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /label="yozS gene" S_feature complement(1723006..1723107) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1723086..1723105) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1723107) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1723120..1723127) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1723135..1723237) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1723177) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1723238..1724416) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" /label="oxdD CDS" gene complement(1723238..1724416) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /label="oxdD gene" promotor_-10 complement(1724442..1724461) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1724461) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1724475..1724484) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1724539..1725027) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" /label="yoaO CDS" gene complement(1724539..1725027) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /label="yoaO gene" downshifts complement(1724564) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" /label="downshifts" CDS complement(1725052..1725207) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" /label="hypothetical protein CDS" gene complement(1725052..1725207) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /label="gene" CDS complement(1725247..1726002) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" /label="yoaP CDS" gene complement(1725247..1726002) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /label="yoaP gene" promotor_-35 1726255..1726260 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1726276..1726294 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1726291 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="upshifts" CDS 1726310..1726666 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" /label="yoaQ CDS" gene 1726310..1726666 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /label="yoaQ gene" CDS complement(1726625..1726864) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" /label="yozT CDS" gene complement(1726625..1726864) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /label="yozT gene" S_feature 1726667..1727103 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1726865..1726966) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1726967..1727464) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" /label="yozF CDS" gene complement(1726967..1727464) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /label="yozF gene" S_feature complement(1727465..1727564) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1727565..1728476) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" /label="yoaR CDS" gene complement(1727565..1728476) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /label="yoaR gene" promotor_-10 complement(1728498..1728509) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1728500) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1728524..1728530) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1728760..1728767 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1728776 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1728782..1728801 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1728823..1729305 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" /label="yoaS CDS" gene 1728823..1729305 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /label="yoaS gene" CDS 1729315..1729569 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" /label="yozG CDS" gene 1729315..1729569 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /label="yozG gene" S_feature 1729570..1729674 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1729675..1730469 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" /label="yoaT CDS" gene 1729675..1730469 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /label="yoaT gene" S_feature 1730470..1731480 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1730593..1731465) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" /label="yoaU CDS" gene complement(1730593..1731465) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /label="yoaU gene" CDS 1731566..1732444 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" /label="yoaV CDS" gene 1731566..1732444 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /label="yoaV gene" S_feature complement(1732557..1732616) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1732592) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1732617..1733048) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" /label="yoaW CDS" gene complement(1732617..1733048) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /label="yoaW gene" promotor_-10 complement(1733068..1733087) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1733076) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1733078..1733311) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1733101..1733107) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1733312..1733330) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1733312..1733944) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" /label="yoaZ CDS" gene complement(1733312..1733944) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /label="yoaZ gene" upshifts complement(1733318) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1733346..1733351) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1734082..1734089 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1734104..1734123 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1734108 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="upshifts" CDS 1734170..1735090 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" /label="penP CDS" gene 1734170..1735090 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /label="penP gene" promotor_-10 complement(1734601..1734620) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1734616) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1734635..1734642) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1735091..1735748 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1735587..1735949) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" /label="yobA CDS" gene complement(1735587..1735949) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /label="yobA gene" CDS complement(1736010..1736222) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" /label="yozU CDS" gene complement(1736010..1736222) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo /label="yozU gene" promotor_-35 1736261..1736268 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1736283..1736302 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1736286 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="upshifts" CDS 1736326..1736589 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" /label="yobB CDS" gene 1736326..1736589 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /label="yobB gene" downshifts 1736567 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1736966..1739566) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" /label="yppS CDS" gene complement(1736966..1739566) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /label="yppS gene" S_feature complement(1739567..1739676) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 1739592..1739599 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1739614..1739633 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1739622..1740249 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 1739622 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1739666..1739685) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1739676) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1739700..1739706) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1739722..1740181) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(1739764) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1740226) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(1740236..1740877) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" /label="xynA CDS" gene complement(1740236..1740877) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /label="xynA gene" S_feature complement(1740878..1740995) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(1740972..1740991) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1740995) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1741005..1741007) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1741083,1741090) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs05" N_region 1741084..1741089 /note="SacI site (GAGCTC)" /modified_by="User" /label="IIG_Bs05" misc_RNA <1741090..1741174 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" /label="bsrF RNA" S_feature <1741090..1741167 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" S_feature complement(<1741090..1741154) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" gene <1741090..1741174 /gene="bsrF" /old_locus_tag="BSU_misc_RNA_75" /locus_tag="PG10_pseudo_BSU_misc_RNA_75" /modified_by="User" /label="PG10_pseudo_BSU_misc_RNA_75" downshifts 1741152 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1741185..1741517) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" /label="csaA CDS" gene complement(1741185..1741517) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /label="csaA gene" downshifts complement(1741199) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1741582..1742307) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" /label="yobQ CDS" gene complement(1741582..1742307) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /label="yobQ gene" CDS complement(1742322..1743065) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" /label="yobR CDS" gene complement(1742322..1743065) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /label="yobR gene" promotor_-10 complement(1743093..1743112) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1743112) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1743126..1743132) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1743143..1743718) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" /label="yobS CDS" gene complement(1743143..1743718) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /label="yobS gene" CDS complement(1743724..1744425) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" /label="yobT CDS" gene complement(1743724..1744425) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /label="yobT gene" promotor_-10 complement(1744455..1744474) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1744455) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1744459..1744474) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1744489..1744496) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1744489..1744496) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1744499) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1744502..1744984) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" /label="yobU CDS" gene complement(1744502..1744984) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /label="yobU gene" misc_feature complement(1745023..1745040) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1745027) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1745038..1745979) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" /label="yobV CDS" gene complement(1745038..1745979) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /label="yobV gene" downshifts complement(1745071) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1746009..1746028) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1746017) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1746042..1746046) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1746050..1746059 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1746072..1746091 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1746080 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="upshifts" S_feature 1746095..1746159 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 1746131..1746136 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1746152..1746170 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1746161 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="upshifts" CDS 1746185..1746730 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" /label="yobW CDS" gene 1746185..1746730 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /label="yobW gene" downshifts 1746689 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS complement(1746757..1747080) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" /label="czrA CDS" gene complement(1746757..1747080) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /label="czrA gene" downshifts complement(1746764) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1747101..1747120) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1747112) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1747133..1747140) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1747201..1747207 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1747218 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1747222..1747241 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1747274..1747951 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" /label="yocA CDS" gene 1747274..1747951 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /label="yocA gene" downshifts 1747943 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1748041..1748577) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" /label="yozB CDS" gene complement(1748041..1748577) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /label="yozB gene" downshifts complement(1748064) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1748604..1748623) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1748624) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1748637..1748644) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1748714..1749496) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" /label="yocB CDS" gene complement(1748714..1749496) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /label="yocB gene" downshifts complement(1748723) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1749518..1749536) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1749537) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1749550..1749556) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1749593..1749600 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1749615..1749634 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1749619 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1749667..1750164 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" /label="yocC CDS" gene 1749667..1750164 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /label="yocC gene" promotor_-35 1750171..1750174 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1750190..1750209 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1750192 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1750228..1751205 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" /label="yocD CDS" gene 1750228..1751205 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /label="yocD gene" downshifts 1751177 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 1751302..1751309 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1751324..1751343 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1751331 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1751367..1752425 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" /label="desE CDS" gene 1751367..1752425 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /label="desE gene" S_feature 1752426..1752495 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 1752479..1752485 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1752497..1752516 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1752497 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1752545..1753657 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" /label="desK CDS" gene 1752545..1753657 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /label="desK gene" CDS 1753676..1754275 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" /label="desR CDS" gene 1753676..1754275 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /label="desR gene" downshifts 1754213 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1754257 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1754297..1754795) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(1754333) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1754767..1754776 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1754779..1754797) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1754788..1754982 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 1754788 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1754789..1754808 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1754795) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1754814..1754819) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1754870..1755733) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" /label="walL CDS" gene complement(1754870..1755733) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /label="walL gene" downshifts complement(1754883) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 1754939 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1754971) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" S_feature 1754984..1755751 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 1755729..1755733 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1755742..1755756 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1755753 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1755772..1755791) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1755785) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1755787..1755980) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(1755803..1755809) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1755981..1757756) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" /label="recQ CDS" gene complement(1755981..1757756) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /label="recQ gene" S_feature complement(1757757..1757887) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(1757880..1758082) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" /label="ssrSA RNA" gene complement(1757880..1758082) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /label="ssrSA gene" downshifts complement(1757932) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1758080..1758099) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(1758098) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="upshifts" S_feature complement(1758100..1758292) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(1758112..1758119) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(1758321..1758947) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" /label="azoJ CDS" gene complement(1758321..1758947) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /label="azoJ gene" downshifts complement(1758337) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1758981..1759000) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(1758994) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="upshifts" promotor_-35 complement(1759014..1759021) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(1759098..1759589) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" /label="yocK CDS" gene complement(1759098..1759589) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /label="yocK gene" downshifts complement(1759107) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1759601..1759619) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(1759613) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="upshifts" promotor_-35 complement(1759633..1759639) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(1759664..1759996) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" /label="yocL CDS" gene complement(1759664..1759996) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /label="yocL gene" S_feature complement(1759997..1760287) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 1760012..1760017 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 1760032..1760050 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 1760034 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="upshifts" CDS 1760074..1760301 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" /label="yoyB CDS" gene 1760074..1760301 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /label="yoyB gene" CDS complement(1760288..1760764) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" /label="yocM CDS" gene complement(1760288..1760764) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /label="yocM gene" S_feature 1760302..1760809 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(1760765..1760867) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 1760782..1760787 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1760802..1760820 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1760811 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="upshifts" CDS 1760831..1761094 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" /label="yozN CDS" gene 1760831..1761094 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /label="yozN gene" promotor_-10 complement(1760847..1760866) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1760867) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1760869..1761394) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(1760880..1760884) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1761099..1761332 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" /label="yocN CDS" gene 1761099..1761332 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /label="yocN gene" downshifts 1761319 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1761418..1761762) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" /label="yozO CDS" gene complement(1761418..1761762) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /label="yozO gene" downshifts complement(1761439) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" /label="downshifts" S_feature complement(1761763..1761835) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(1761831..1761850) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1761835) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1761837..1761940) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(1761864..1761869) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1761927..1761942) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1761940) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1761955..1761964) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1762083) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1762119..1762322) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" /label="yozC CDS" gene complement(1762119..1762322) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /label="yozC gene" promotor_-10 complement(1762343..1762362) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1762361) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1762363..1762429) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(1762378..1762385) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1762395..1762402 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 1762414 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="upshifts" misc_feature complement(1762416..1762428) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1762416..1762435 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 1762419..1762551 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(1762440) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="upshifts" CDS 1762552..1764039 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" /label="dhaS CDS" gene 1762552..1764039 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /label="dhaS gene" promotor_-10 complement(1762995..1763012) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1763001) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1763025..1763033) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1764025 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1764087..1764092 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1764108..1764126 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1764113 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="upshifts" CDS 1764140..1766038 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" /label="sqhC CDS" gene 1764140..1766038 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /label="sqhC gene" promotor_-10 complement(1765083..1765102) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1765091) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1765116..1765125) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1766028..1766873 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" /label="sodF CDS" gene 1766028..1766873 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /label="sodF gene" S_feature 1766874..1768380 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(1766906..1768243) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" /label="yocR CDS" gene complement(1766906..1768243) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /label="yocR gene" downshifts complement(1766917) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1768271..1768290) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1768286) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1768288..1769446) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(1768305..1768312) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1768364..1768367 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1768382..1768401 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1768382 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="upshifts" CDS 1768462..1769427 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" /label="yocS CDS" gene 1768462..1769427 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /label="yocS gene" downshifts 1769415 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1769477..1770730) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" /label="odhB CDS" gene complement(1769477..1770730) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /label="odhB gene" downshifts complement(1769491) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" CDS complement(1770746..1773580) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" /label="odhA CDS" gene complement(1770746..1773580) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /label="odhA gene" promotor_-10 complement(1773675..1773694) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1773690) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1773692..1773808) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(1773709..1773716) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1773809..1775725) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" /label="yojO CDS" gene complement(1773809..1775725) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /label="yojO gene" CDS complement(1775736..1776650) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" /label="yojN CDS" gene complement(1775736..1776650) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /label="yojN gene" promotor_-10 complement(1776654..1776673) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(1776669) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="upshifts" promotor_-35 complement(1776690..1776694) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(1776714..1777304) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" /label="sodC CDS" gene complement(1776714..1777304) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /label="sodC gene" CDS complement(1777397..1778641) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" /label="cwlS CDS" gene complement(1777397..1778641) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /label="cwlS gene" downshifts complement(1777399) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1778704..1778722) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1778717) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1778719..1778939) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(1778735..1778742) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1778925..1778943) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1778939) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1778955..1778963) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1779023..1780240) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" /label="yojK CDS" gene complement(1779023..1780240) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /label="yojK gene" downshifts complement(1779049) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1780273..1780292) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1780281) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1780306..1780313) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1780476..1781099) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" /label="cdaS CDS" gene complement(1780476..1781099) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /label="cdaS gene" S_feature complement(1781100..1781250) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 1781126..1781132 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1781138 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1781146..1781157 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1781164..1781172 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1781180..1781280 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 1781184..1781202 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1781195 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1781233..1781251) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1781240..1781325 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 1781240 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1781250) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1781267..1781273) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1781301..1781308 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1781321..1781340 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1781327 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="upshifts" CDS 1781365..1782723 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" /label="mdtK CDS" gene 1781365..1782723 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /label="mdtK gene" promotor_-10 complement(1781707..1781718) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1781712) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1781732..1781738) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1782739..1783587 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" /label="rsbRC CDS" gene 1782739..1783587 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /label="rsbRC gene" promotor_-10 complement(1783003..1783022) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1783010) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1783036..1783044) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1783550 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1783582) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1783613..1784278) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" /label="bshBB CDS" gene complement(1783613..1784278) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /label="bshBB gene" downshifts complement(1783627) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1784297..1784647) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" /label="yojF CDS" gene complement(1784297..1784647) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /label="yojF gene" CDS complement(1784644..1784922) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" /label="yoyC CDS" gene complement(1784644..1784922) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /label="yoyC gene" promotor_-10 complement(1784949..1784968) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1784965) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1784983..1784989) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1784998..1785894) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" /label="yojE CDS" gene complement(1784998..1785894) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /label="yojE gene" promotor_-35 1785736..1785745 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1785756 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1785759..1785778 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1785774..1785992 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(1785918..1785937) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1785938) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1785949..1785956) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1785993..1786466 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" /label="gerT CDS" gene 1785993..1786466 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /label="gerT gene" downshifts 1786463 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1786501..1786737) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" /label="yojB CDS" gene complement(1786501..1786737) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /label="yojB gene" downshifts complement(1786509) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1786760..1786779) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1786775) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1786793..1786802) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1786822..1788156) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" /label="yojA CDS" gene complement(1786822..1788156) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /label="yojA gene" S_feature complement(1788157..1788292) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(1788289..1788308) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1788299) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1788323..1788330) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1788388..1788395 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1788410..1788429 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1788413 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1788414..1788520 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 1788521..1788910 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" /label="yodA CDS" gene 1788521..1788910 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /label="yodA gene" downshifts 1788920 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1789317..1789655) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" /label="arxR CDS" gene complement(1789317..1789655) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /label="arxR gene" promotor_-35 1789678..1789685 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1789699..1789718 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1789708 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="upshifts" S_feature 1789712..1789784 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(1789743..1789762) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1789746) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1789774..1789780) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1789785..1790393 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" /label="noxC CDS" gene 1789785..1790393 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /label="noxC gene" downshifts 1790383 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1790436..1791038) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" /label="yodD CDS" gene complement(1790436..1791038) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /label="yodD gene" CDS complement(1791054..1791965) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" /label="yodE CDS" gene complement(1791054..1791965) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /label="yodE gene" promotor_-10 complement(1791994..1792013) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1792010) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1792029..1792034) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1792086..1792089 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1792104..1792123 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1792106 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="upshifts" CDS 1792149..1792349 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" /label="yoyD CDS" gene 1792149..1792349 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /label="yoyD gene" CDS 1792349..1793839 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" /label="yodF CDS" gene 1792349..1793839 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /label="yodF gene" promotor_-10 complement(1793084..1793095) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1793088) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1793109..1793115) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1793827 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1793874..1795274) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" /label="ctpA CDS" gene complement(1793874..1795274) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /label="ctpA gene" downshifts complement(1793898) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-35 1795045..1795054 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1795066..1795081 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1795080 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1795294..1795313) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1795314) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1795327..1795334) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1795373..1795382 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1795388 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1795395..1795414 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1795427..1796128 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" /label="yodH CDS" gene 1795427..1796128 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /label="yodH gene" promotor_-35 1796153..1796161 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1796175..1796194 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1796180 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="upshifts" CDS 1796216..1796467 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" /label="yodI CDS" gene 1796216..1796467 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /label="yodI gene" downshifts 1796488 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1796538..1797359) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" /label="ldcB CDS" gene complement(1796538..1797359) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /label="ldcB gene" downshifts complement(1796564) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1797360..1797441) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(1797442..1798143) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" /label="deoD CDS" gene complement(1797442..1798143) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /label="deoD gene" S_feature complement(1798144..1798233) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(1798218..1798237) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1798233) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1798253..1798257) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1798291..1798297 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1798312..1798323 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1798329 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="upshifts" CDS 1798345..1798470 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" /label="yoyE CDS" gene 1798345..1798470 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /label="yoyE gene" downshifts 1798468 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1798510..1798824) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" /label="yodL CDS" gene complement(1798510..1798824) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /label="yodL gene" downshifts complement(1798522) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1798845..1798863) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1798852) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1798874..1798882) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1798885..1799496) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" /label="pgpB CDS" gene complement(1798885..1799496) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /label="pgpB gene" CDS complement(1799574..1799750) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" /label="yozD CDS" gene complement(1799574..1799750) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /label="yozD gene" downshifts complement(1799578) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1799589) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1799593..1799612) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1799628..1799631) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1799764..1799782) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(1799785) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="upshifts" S_feature complement(1799787..1800008) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(1799798..1799803) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 1799808..1799813 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1799828..1799846 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1799830 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="upshifts" CDS 1799869..1800012 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" /label="yoyF CDS" gene 1799869..1800012 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /label="yoyF gene" CDS complement(1800009..1800689) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" /label="yodN CDS" gene complement(1800009..1800689) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /label="yodN gene" S_feature 1800013..1801024 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(1800716..1800735) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1800722) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1800749..1800758) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1800840..1801064) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" /label="yozE CDS" gene complement(1800840..1801064) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /label="yozE gene" downshifts complement(1800854) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1801105..1801124) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1801117) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1801151..1801429) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" /label="yokU CDS" gene complement(1801151..1801429) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /label="yokU gene" CDS complement(1801426..1802841) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" /label="kamA CDS" gene complement(1801426..1802841) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /label="kamA gene" promotor_-35 1802097..1802100 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1802116..1802135 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1802121 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1802870..1803697) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " /label="kamB CDS" gene complement(1802870..1803697) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /label="kamB gene" CDS complement(1803675..1804985) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" /label="yodQ CDS" gene complement(1803675..1804985) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /label="yodQ gene" CDS complement(1804994..1805647) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " /label="yodR CDS" gene complement(1804994..1805647) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /label="yodR gene" CDS complement(1805632..1806321) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" /label="yodS CDS" gene complement(1805632..1806321) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /label="yodS gene" CDS complement(1806328..1807662) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" /label="yodT CDS" gene complement(1806328..1807662) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /label="yodT gene" CDS complement(1807643..1807798) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" /label="conserved hypothetical protein CDS" gene complement(1807643..1807798) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /label="gene" promotor_-10 complement(1807681..1807699) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1807697) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1807715..1807720) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1807792..1808025) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" /label="yoyG CDS" gene complement(1807792..1808025) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /label="yoyG gene" downshifts complement(1807799) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 1807901..1807905 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1807914..1807928 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1807929 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1807930..1807949) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1807939) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1807964..1807973) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1807985..1808764) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" /label="cgeE CDS" gene complement(1807985..1808764) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /label="cgeE gene" CDS complement(1808793..1810073) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" /label="cgeD CDS" gene complement(1808793..1810073) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /label="cgeD gene" promotor_-10 complement(1809441..1809459) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1809457) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1809473..1809480) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1810041..1810059) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1810051) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1810075..1810080) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1810138..1810443) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " /label="cgeC CDS" gene complement(1810138..1810443) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /label="cgeC gene" downshifts complement(1810271) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1810467..1810486) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(1810482) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="upshifts" promotor_-35 complement(1810500..1810509) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 1810579..1810588 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1810602..1810621 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1810602 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1810623) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1810625..1810639) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1810648..1810652) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1810648..1811049 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" /label="cgeA CDS" gene 1810648..1811049 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /label="cgeA gene" CDS 1811056..1812009 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" /label="cgeB CDS" gene 1811056..1812009 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /label="cgeB gene" downshifts 1811999 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1812080..1813228) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" /label="phyC CDS" gene complement(1812080..1813228) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /label="phyC gene" downshifts complement(1812097) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" promotor_-35 1813241..1813245 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1813254..1813273) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1813261..1813280 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1813263) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 1813271 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1813532..1813540 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1813554..1813573 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1813557 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="upshifts" CDS 1813598..1814623 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 1813598..1814623 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 1814001 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 <1814003..1814007 /Source="Nicolas_upshift_promotors" /id="U1702" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1418 /SigmaFactorBS="tttcatttttgacctcacagccactaATAGTTTCCActaaga aaagtagTAAGTATCTTAAAAAACAGAtaaagctgtatctcctgtgaacacaatgggt g" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" SCAR 1814017..1814018 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 1814615 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1814667..1815098) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" /label="msrB CDS" gene complement(1814667..1815098) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /label="msrB gene" downshifts complement(1814672) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1815099..1815632) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" /label="msrA CDS" gene complement(1815099..1815632) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /label="msrA gene" promotor_-35 1815636..1815642 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1815653..1815763 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 1815653 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1815655..1815674 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1815660..1815679) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1815680) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1815695..1815696) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1815764..1816189 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" /label="ypoP CDS" gene 1815764..1816189 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /label="ypoP gene" downshifts 1816177 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 1816222..1817453 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(1816239..1817576) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" /label="dinF CDS" gene complement(1816239..1817576) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /label="dinF gene" CDS complement(1817648..1817842) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" /label="ypmT CDS" gene complement(1817648..1817842) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /label="ypmT gene" downshifts complement(1817661) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1817855..1818418) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" /label="ypmS CDS" gene complement(1817855..1818418) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /label="ypmS gene" CDS complement(1818428..1819195) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" /label="ypmR CDS" gene complement(1818428..1819195) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /label="ypmR gene" promotor_-10 complement(1819219..1819238) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1819236) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1819249..1819256) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1819273..1819854) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" /label="scuA CDS" gene complement(1819273..1819854) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /label="scuA gene" S_feature complement(1819855..1819970) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(1820002..1820253) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" /label="ypmP CDS" gene complement(1820002..1820253) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /label="ypmP gene" downshifts complement(1820015) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1820276..1820295) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1820290) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1820339..1821607) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" /label="ilvA CDS" gene complement(1820339..1821607) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /label="ilvA gene" promotor_-10 complement(1821641..1821660) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1821660) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1821672..1821679) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1821814..1821833 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1821817 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="upshifts" CDS 1821856..1822851 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" /label="silP CDS" gene 1821856..1822851 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /label="silP gene" CDS 1822872..1823513 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" /label="yplQ CDS" gene 1822872..1823513 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /label="yplQ gene" S_feature 1823514..1824615 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(1823552..1824172) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" /label="ypkP CDS" gene complement(1823552..1824172) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /label="ypkP gene" downshifts complement(1823578) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1824173..1824679) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" /label="dfrA CDS" gene complement(1824173..1824679) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /label="dfrA gene" CDS complement(1824676..1825470) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" /label="thyB CDS" gene complement(1824676..1825470) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /label="thyB gene" CDS complement(1825554..1826087) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" /label="ypjQ CDS" gene complement(1825554..1826087) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /label="ypjQ gene" downshifts complement(1825559) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" /label="downshifts" promotor_-35 1826017..1826022 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1826033..1826979 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 1826035 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1826039..1826057 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1826105..1826716) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" /label="ypjP CDS" gene complement(1826105..1826716) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /label="ypjP gene" promotor_-10 complement(1826748..1826767) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1826767) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1826780..1826785) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1826936 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" /label="downshifts" CDS complement(1826976..1827749) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" /label="rsmJ CDS" gene complement(1826976..1827749) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /label="rsmJ gene" downshifts complement(1827011) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(1827791..1828225) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" /label="brxA CDS" gene complement(1827791..1828225) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /label="brxA gene" downshifts complement(1827803) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1828254..1828273) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(1828265) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="upshifts" S_feature complement(1828267..1828331) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(1828287..1828294) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(1828310) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1828332..1830008) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" /label="ilvD CDS" gene complement(1828332..1830008) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /label="ilvD gene" S_feature complement(1830009..1830199) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(1830188..1830207) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1830199) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1830222..1830225) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1830297..1831430) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" /label="ypgR CDS" gene complement(1830297..1831430) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /label="ypgR gene" downshifts complement(1830313) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature complement(1831452..1831471) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1831455) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1831490..1832107) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" /label="hdhQ CDS" gene complement(1831490..1832107) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /label="hdhQ gene" CDS complement(1832123..1832605) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" /label="bsaA CDS" gene complement(1832123..1832605) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /label="bsaA gene" S_feature complement(1832606..1832753) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(1832744..1832762) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(1832754) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="upshifts" promotor_-35 complement(1832773..1832781) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 1832807..1832816 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1832829..1832844 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 1832831..1832917 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 1832831 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" promotor_-35 1832880..1832887 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 1832902..1832921 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 1832919 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" CDS 1832948..1833853 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" /label="metAA CDS" gene 1832948..1833853 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /label="metAA gene" misc_feature 1833888..1833907 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1833902 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" S_feature 1833903..1834083 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 1834084..1835232 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" /label="ugtP CDS" gene 1834084..1835232 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /label="ugtP gene" S_feature complement(1834253..1835282) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 1835228 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1835264..1835283) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1835282) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1835298..1835306) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1835313..1835459 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" /label="hypothetical protein CDS" gene 1835313..1835459 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /label="gene" promotor_-35 1835352..1835359 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1835373..1835392 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1835384..1835474 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 1835384 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1835475..1835675 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" /label="cspD CDS" gene 1835475..1835675 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /label="cspD gene" downshifts 1835690 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS complement(1835727..1835909) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" /label="degR CDS" gene complement(1835727..1835909) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /label="degR gene" S_feature 1835735..1836040 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(1835744) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1835970..1835988) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1836002..1836008) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1836006) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1836016..1836022 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1836037..1836048 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1836042 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 1836065..1836334 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" /label="ypzA CDS" gene 1836065..1836334 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /label="ypzA gene" downshifts 1836189 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" /label="downshifts" downshifts 1836317 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(1836362..1836544) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" /label="ypeQ CDS" gene complement(1836362..1836544) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /label="ypeQ gene" downshifts complement(1836382) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1836537..1837217) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" /label="ypeP CDS" gene complement(1836537..1837217) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /label="ypeP gene" S_feature complement(1837218..1837355) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 1837234..1837239 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1837252..1837271 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1837257 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1837300..1837989 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" /label="queP CDS" gene 1837300..1837989 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /label="queP gene" promotor_-35 complement(1837353..1837369) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1837356) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1837357..1837746) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(1837727..1837746) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1837744) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1837758..1837766) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1837989..1838387 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" /label="ypdQ CDS" gene 1837989..1838387 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /label="ypdQ gene" promotor_-35 1838380..1838386 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1838401..1838412 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1838412 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 1838429..1838557 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" /label="sspL CDS" gene 1838429..1838557 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /label="sspL gene" S_feature 1838558..1839538 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(1838565..1839455) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" /label="exnP CDS" gene complement(1838565..1839455) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /label="exnP gene" downshifts complement(1838602) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1839477..1839496) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1839484) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1839508..1839514) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1839512 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(1839556..1839702) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" /label="ypzF CDS" gene complement(1839556..1839702) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /label="ypzF gene" downshifts complement(1839572) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1839726) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1839727..1839738) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1839753..1839759) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1839777..1840034) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" /label="ypbS CDS" gene complement(1839777..1840034) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /label="ypbS gene" promotor_-10 complement(1840054..1840073) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1840069) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1840085..1840092) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1840099..1843680) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" /label="dynA CDS" gene complement(1840099..1843680) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /label="dynA gene" S_feature complement(1843681..1843752) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(1843742..1843761) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1843752) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="upshifts" S_feature complement(1843797..1843994) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(1843840) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1843856..1843945) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" /label="fbpC CDS" gene complement(1843856..1843945) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /label="fbpC gene" promotor_-10 complement(1843973..1843992) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1843994) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1844007..1844014) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1844016..1844522) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" /label="bpsB CDS" gene complement(1844016..1844522) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /label="bpsB gene" CDS complement(1844526..1845623) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" /label="bpsA CDS" gene complement(1844526..1845623) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /label="bpsA gene" promotor_-10 complement(1845641..1845652) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1845644) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1845667..1845673) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1845697..1847013) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" /label="pbuX CDS" gene complement(1845697..1847013) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /label="pbuX gene" downshifts complement(1845710) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1847010..1847594) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" /label="xpt CDS" gene complement(1847010..1847594) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /label="xpt gene" misc_RNA complement(1847683..1847783) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswA RNA" gene complement(1847683..1847783) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /label="gswA gene" downshifts complement(1847690) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" S_feature complement(1847784..1847924) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(1847925..1849430) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" /label="ypwA CDS" gene complement(1847925..1849430) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /label="ypwA gene" promotor_no_box complement(1849366..1849466) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1849406) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" downshifts 1849418 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1849456..1849475) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1849472) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1849489..1849496) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1849542..1850534) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" /label="kdgT CDS" gene complement(1849542..1850534) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /label="kdgT gene" downshifts complement(1849560) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1850579..1851169) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" /label="kdgA CDS" gene complement(1850579..1851169) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /label="kdgA gene" CDS complement(1851171..1852145) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" /label="kdgK CDS" gene complement(1851171..1852145) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /label="kdgK gene" CDS complement(1852183..1853202) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" /label="kdgR CDS" gene complement(1852183..1853202) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /label="kdgR gene" promotor_-10 complement(1853250..1853269) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1853260) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1853281..1853288) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1853323..1853330 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1853344..1853423 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 1853344 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1853345..1853364 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1853424..1854251 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " /label="kduI CDS" gene 1853424..1854251 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /label="kduI gene" CDS 1854253..1855017 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" /label="kduD CDS" gene 1854253..1855017 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /label="kduD gene" downshifts 1855006 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1855048) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(1855058..1856983) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" /label="ypvA CDS" gene complement(1855058..1856983) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /label="ypvA gene" promotor_-10 complement(1857014..1857033) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1857018) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1857020..1857084) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(1857048..1857052) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1857085..1857276) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" /label="yptA CDS" gene complement(1857085..1857276) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /label="yptA gene" promotor_-10 complement(1857295..1857313) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1857304) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1857306..1857611) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(1857329..1857334) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1857343..1857349 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1857364..1857375 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1857373 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="upshifts" CDS 1857440..1857592 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" /label="ypzG CDS" gene 1857440..1857592 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /label="ypzG gene" downshifts 1857602 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1857645..1858802) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" /label="rlmKB CDS" gene complement(1857645..1858802) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /label="rlmKB gene" downshifts complement(1857656) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1858890..1859290) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rnpB RNA" gene complement(1858890..1859290) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /label="rnpB gene" downshifts complement(1858900) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1859287..1859306) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1859305) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1859321..1859327) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1859349..1859645) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" /label="gpsB CDS" gene complement(1859349..1859645) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /label="gpsB gene" promotor_-10 complement(1859670..1859689) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1859680) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1859703..1859710) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1859723..1860352) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" /label="ypsA CDS" gene complement(1859723..1860352) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /label="ypsA gene" downshifts complement(1860318) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1860354..1860581) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" /label="cotD CDS" gene complement(1860354..1860581) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /label="cotD gene" promotor_-10 complement(1860609..1860628) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(1860624) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="upshifts" S_feature complement(1860626..1860780) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(1860642..1860650) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(1860665..1860793) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" /label="conserved protein of unknown function CDS" gene complement(1860665..1860793) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /label="gene" upshifts complement(1860780) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" S_feature complement(1860782..1860893) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(1860783..1860802) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(1860818..1860822) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1860894..1862135) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" /label="yprB CDS" gene complement(1860894..1862135) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /label="yprB gene" promotor_-10 complement(1861849..1861867) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(1861858) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="upshifts" promotor_-35 complement(1861882..1861889) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(1862151..1864400) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" /label="yprA CDS" gene complement(1862151..1864400) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /label="yprA gene" promotor_-10 complement(1864416..1864435) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1864432) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1864449..1864455) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(1864503..1865009) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" /label="ypqE CDS" gene complement(1864503..1865009) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /label="ypqE gene" downshifts complement(1864526) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1865053..1865072) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(1865070) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(1865086..1865093) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 1865091..1865100 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1865114..1865133 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1865126 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="upshifts" CDS 1865147..1865566 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" /label="ypqA CDS" gene 1865147..1865566 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /label="ypqA gene" S_feature 1865567..1865717 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(1865587..1865964) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" /label="yppG CDS" gene complement(1865587..1865964) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /label="yppG gene" downshifts complement(1865620) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature 1865962..1866107 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(1865994..1866012) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1866013) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1866026..1866035) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1866108..1866127 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1866109 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1866152..1866340 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" /label="yppF CDS" gene 1866152..1866340 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /label="yppF gene" downshifts 1866356 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" CDS complement(1866379..1866750) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" /label="yppE CDS" gene complement(1866379..1866750) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /label="yppE gene" downshifts complement(1866412) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1866762..1866781) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1866775) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1866794..1866799) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1866796..1867041) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" /label="yppD CDS" gene complement(1866796..1867041) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /label="yppD gene" promotor_-10 complement(1867067..1867085) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1867072) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1867097..1867105) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1867191..1867197 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1867212..1867223 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1867219 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="upshifts" CDS 1867240..1867344 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" /label="sspM CDS" gene 1867240..1867344 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /label="sspM gene" downshifts 1867326 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1867369..1868331) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" /label="yppC CDS" gene complement(1867369..1868331) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /label="yppC gene" promotor_-35 1867499..1867508 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1867520..1867535 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1867520 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1867524..1867859 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 1867830..1867834 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1867850..1867869 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1867861..1868371 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 1867861 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1868332..1868788) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 1868372..1868992 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" /label="recU CDS" gene 1868372..1868992 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /label="recU gene" promotor_-10 complement(1868777..1868788) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1868788) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1868803..1868809) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1869014..1871758 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" /label="ponA CDS" gene 1869014..1871758 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /label="ponA gene" downshifts complement(1871428) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" /label="downshifts" downshifts 1871744 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1871834..1872328) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" /label="ypoC CDS" gene complement(1871834..1872328) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /label="ypoC gene" downshifts complement(1871847) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1872325..1872984) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" /label="nth CDS" gene complement(1872325..1872984) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /label="nth gene" CDS complement(1873003..1873701) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" /label="dnaD CDS" gene complement(1873003..1873701) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /label="dnaD gene" S_feature complement(1873702..1873793) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(1873794..1875086) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" /label="asnS CDS" gene complement(1873794..1875086) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /label="asnS gene" S_feature complement(1875087..1875148) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(1875148..1875167) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1875148) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1875182..1875189) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1875230..1876411) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" /label="aspB CDS" gene complement(1875230..1876411) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /label="aspB gene" downshifts complement(1875234) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1876434..1876919) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" /label="tseB CDS" gene complement(1876434..1876919) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /label="tseB gene" promotor_-10 complement(1876867..1876886) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1876884) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1876899..1876906) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1876928..1877098) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" /label="ypmA CDS" gene complement(1876928..1877098) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /label="ypmA gene" S_feature complement(1877099..1877170) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 1877132..1877138 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1877153..1877172) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1877153..1877164 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1877160..1877234 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 1877160 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1877170) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1877172..1877240) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(1877188..1877194) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1877204 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1877241..1880036) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" /label="dinG CDS" gene complement(1877241..1880036) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /label="dinG gene" promotor_-35 1877709..1877713 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1877710 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1877715..1877719 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1878366..1878381) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1878380) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1878394..1878403) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(1880037..1880161) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(1880162..1880545) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" /label="panD CDS" gene complement(1880162..1880545) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /label="panD gene" CDS complement(1880547..1881407) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" /label="panC CDS" gene complement(1880547..1881407) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /label="panC gene" CDS complement(1881409..1882242) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" /label="panB CDS" gene complement(1881409..1882242) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /label="panB gene" S_feature complement(1882243..1882450) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(1882445..1882464) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1882450) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1882481..1882485) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1882488..1883465) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" /label="birA CDS" gene complement(1882488..1883465) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /label="birA gene" CDS complement(1883450..1884643) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" /label="cca CDS" gene complement(1883450..1884643) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /label="cca gene" CDS complement(1884648..1885781) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" /label="bshA CDS" gene complement(1884648..1885781) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /label="bshA gene" CDS complement(1885778..1886488) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" /label="bshBA CDS" gene complement(1885778..1886488) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /label="bshBA gene" CDS complement(1886481..1886894) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" /label="mgsA CDS" gene complement(1886481..1886894) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /label="mgsA gene" CDS complement(1886910..1887713) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" /label="dapB CDS" gene complement(1886910..1887713) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /label="dapB gene" CDS complement(1887725..1888060) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" /label="ypjD CDS" gene complement(1887725..1888060) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /label="ypjD gene" promotor_-10 complement(1888080..1888099) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(1888090) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(1888113..1888120) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 1888129..1888136 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1888145..1888164) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1888150..1888169 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1888156 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1888164) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" CDS 1888200..1889072 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" /label="ypjC CDS" gene 1888200..1889072 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /label="ypjC gene" CDS complement(1889114..1889908) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" /label="ypjB CDS" gene complement(1889114..1889908) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /label="ypjB gene" downshifts complement(1889139) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" /label="downshifts" S_feature complement(1889909..1889976) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(1889977..1890534) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" /label="ypjA CDS" gene complement(1889977..1890534) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /label="ypjA gene" S_feature complement(1890535..1890614) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(1890659) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1890681..1891448) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" /label="qcrC CDS" gene complement(1890681..1891448) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /label="qcrC gene" CDS complement(1891483..1892157) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" /label="qcrB CDS" gene complement(1891483..1892157) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /label="qcrB gene" CDS complement(1892159..1892662) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" /label="qcrA CDS" gene complement(1892159..1892662) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /label="qcrA gene" downshifts 1892671 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1892726..1892745) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1892726) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1892760..1892767) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1892805..1893251) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" /label="ypiF CDS" gene complement(1892805..1893251) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /label="ypiF gene" downshifts 1893254 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" /label="downshifts" CDS complement(1893306..1893845) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" /label="ypiB CDS" gene complement(1893306..1893845) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /label="ypiB gene" downshifts complement(1893319) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1893878..1893896) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1893889) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="upshifts" promotor_-35 complement(1893908..1893916) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(1893917..1895188) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" /label="ypiA CDS" gene complement(1893917..1895188) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /label="ypiA gene" S_feature complement(1895189..1895256) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(1895253..1895272) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1895256) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1895286..1895293) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1895323..1895342) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(1895329) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="upshifts" S_feature complement(1895331..1895475) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(1895353..1895360) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(1895457..1895475) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1895475) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1895491..1895496) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1895524..1896810) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" /label="aroA CDS" gene complement(1895524..1896810) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /label="aroA gene" downshifts complement(1895547) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1896821..1897936) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" /label="tyrA CDS" gene complement(1896821..1897936) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /label="tyrA gene" CDS complement(1897985..1899067) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" /label="hisC CDS" gene complement(1897985..1899067) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /label="hisC gene" CDS complement(1899078..1899881) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" /label="trpA CDS" gene complement(1899078..1899881) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /label="trpA gene" promotor_-10 complement(1899566..1899585) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(1899583) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(1899597..1899604) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(1899874..1901076) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" /label="trpB CDS" gene complement(1899874..1901076) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /label="trpB gene" CDS complement(1901057..1901704) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" /label="trpF CDS" gene complement(1901057..1901704) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /label="trpF gene" downshifts complement(1901151) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" /label="downshifts" misc_feature complement(1901327..1901330) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1901327) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" downshifts complement(1901547) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" /label="downshifts" misc_feature 1901709..1902461 /created_by="AR/SM" /id="IIG_Bs01" /note="due to the curing of the trpC2 locus (auxotrophy) of the Delta6 strain by transformation with chromosomal DNA from donor Bsu 3NA multiple snp`s were transferred to the oroginal trpC locus" /modified_by="User" /label="IIG_Bs01" /note="Geneious type: MiniBacillus__exchange" CDS complement(1901709..1902461) /locus_tag="PG10_trpC_var_BEP06_07765" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_007409461.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /protein_id="ANY35339.1" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASLNRFIGLIA EVKKASPSKGLIKENFVPVRIAKDYETAKADALSVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKEMDVLVEVHDA TTLEQILKVFTPDILGINNRNLKTFETSIMQTEQIASLAPKESLLVSESGIGSLEHLT FVKEHGARAVLIGESLMRQTSQRKAIHALFRE*" /label="PG10_trpC_var_BEP06_07765" gene complement(1901709..1902461) /locus_tag="PG10_trpC_var_BEP06_07765" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /label="PG10_trpC_var_BEP06_07765" misc_feature complement(1901742..1901744) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1901745 /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" Polymorphism join(1901851,1901854) /Source="geneious" /ID="SNP_BsPG10_2374282_2374283" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change /CDS_Position=606 /Change="AG -> GT" /Codon_Change="TCC,TTG -> TCA,CTG" /Coverage="129 -> 130" /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="AG" /Variant_Nucleotides="GT" /Variant_P_Value="2e-203" /Variant_Raw_Frequency="128 -> 129" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1901865,1901867) /Source="geneious" /ID="SNP_BsPG10_2374296_2374296" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> A" /CDS_Position=593 /Change="A -> G" /Codon_Change="GTT -> GCT" /Coverage=119 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.2e-179" /Variant_Raw_Frequency=119 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1901867,1901869) /Source="geneious" /ID="SNP_BsPG10_2374298_2374298" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=591 /Change="G -> A" /Codon_Change="CTC -> CTT" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="9.9e-148" /Variant_Raw_Frequency=116 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1901892,1901894) /Source="geneious" /ID="SNP_BsPG10_2374323_2374323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="K -> M" /CDS_Position=566 /Change="T -> A" /Codon_Change="AAG -> ATG" /Coverage=81 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="A" /Variant_P_Value="6.3e-98" /Variant_Raw_Frequency=81 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1901894,1901898) /Source="geneious" /ID="SNP_BsPG10_2374325_2374327" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="V -> I" /CDS_Position=562 /Change="TAC -> GAT" /Codon_Change="GTA -> ATC" /Coverage="79 -> 84" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="TAC" /Variant_Nucleotides="GAT" /Variant_P_Value="2.3e-77" /Variant_Raw_Frequency="74 -> 78" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1901900,1901902) /Source="geneious" /ID="SNP_BsPG10_2374331_2374331" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=558 /Change="T -> G" /Codon_Change="ACA -> ACC" /Coverage=70 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="1e-63" /Variant_Raw_Frequency=70 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1901909,1901911) /Source="geneious" /ID="SNP_BsPG10_2374340_2374340" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=549 /Change="C -> A" /Codon_Change="ACG -> ACT" /Coverage=59 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="A" /Variant_P_Value="1e-59" /Variant_Raw_Frequency=59 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1901924,1901926) /Source="geneious" /ID="SNP_BsPG10_2374355_2374355" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=534 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=66 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="6e-64" /Variant_Raw_Frequency=65 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1901927,1901929) /Source="geneious" /ID="SNP_BsPG10_2374358_2374358" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=531 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=63 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.3e-68" /Variant_Raw_Frequency=60 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1901932,1901934) /Source="geneious" /ID="SNP_BsPG10_2374363_2374363" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> I" /CDS_Position=526 /Change="C -> T" /Codon_Change="GTA -> ATA" /Coverage=65 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="3.9e-82" /Variant_Raw_Frequency=64 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1901942,1901944) /Source="geneious" /ID="SNP_BsPG10_2374373_2374373" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=516 /Change="G -> A" /Codon_Change="GAC -> GAT" /Coverage=79 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="7.7e-116" /Variant_Raw_Frequency=78 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1901945,1901947) /Source="geneious" /ID="SNP_BsPG10_2374376_2374376" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=513 /Change="G -> A" /Codon_Change="CCC -> CCT" /Coverage=92 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="4e-141" /Variant_Raw_Frequency=90 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1901948,1901950) /Source="geneious" /ID="SNP_BsPG10_2374379_2374379" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=510 /Change="T -> C" /Codon_Change="ACA -> ACG" /Coverage=97 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.3e-165" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1901954,1901956) /Source="geneious" /ID="SNP_BsPG10_2374385_2374385" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=504 /Change="C -> T" /Codon_Change="GTG -> GTA" /Coverage=109 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="4.3e-193" /Variant_Raw_Frequency=108 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1901980,1901982) /Source="geneious" /ID="SNP_BsPG10_2374411_2374411" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="S -> T" /CDS_Position=478 /Change="A -> T" /Codon_Change="TCA -> ACA" /Coverage=148 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value="2.9e-307" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1902012,1902014) /Source="geneious" /ID="SNP_BsPG10_2374443_2374443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="G -> E" /CDS_Position=446 /Change="C -> T" /Codon_Change="GGG -> GAG" /Coverage=161 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=161 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1902065,1902067) /Source="geneious" /ID="SNP_BsPG10_2374496_2374496" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=393 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=174 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1902113,1902115) /Source="geneious" /ID="SNP_BsPG10_2374544_2374544" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=345 /Change="T -> C" /Codon_Change="GTA -> GTG" /Coverage=168 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=167 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1902128,1902132) /Source="geneious" /ID="SNP_BsPG10_2374559_2374558" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=0 /Amino_Acid_Change="-> I" /CDS_Position=331 /Change="AAT" /Codon_Change="-> ATT" /Coverage=164 /locus_tag="BSU_22660" /Protein_Effect="Insertion" /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="AAT" /Variant_P_Value="3.90000001038273e-316" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1902146,1902148) /Source="geneious" /ID="SNP_BsPG10_2374574_2374574" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=315 /Change="A -> G" /Codon_Change="CTT -> CTC" /Coverage=155 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1902155,1902157) /Source="geneious" /ID="SNP_BsPG10_2374583_2374583" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=306 /Change="A -> T" /Codon_Change="ATT -> ATA" /Coverage=153 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=152 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1902167,1902169) /Source="geneious" /ID="SNP_BsPG10_2374595_2374595" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=294 /Change="A -> G" /Codon_Change="CGT -> CGC" /Coverage=128 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="4e-295" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1902232,1902234) /Source="geneious" /ID="SNP_BsPG10_2374660_2374660" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="I -> L" /CDS_Position=229 /Change="T -> G" /Codon_Change="ATT -> CTT" /Coverage=131 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="2.3e-302" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1902242,1902244) /Source="geneious" /ID="SNP_BsPG10_2374670_2374670" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=219 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=126 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="1.6e-290" /Variant_Raw_Frequency=126 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1902250,1902253) /Source="geneious" /ID="SNP_BsPG10_2374678_2374679" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="EA -> ET" /CDS_Position=210 /Change="CC -> TT" /Codon_Change="GAG,GCT -> GAA,ACT" /Coverage="124 -> 130" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="CC" /Variant_Nucleotides="TT" /Variant_P_Value="4.7e-253" /Variant_Raw_Frequency="119 -> 125" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1902270,1902272) /Source="geneious" /ID="SNP_BsPG10_2374698_2374698" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="Q -> R" /CDS_Position=191 /Change="T -> C" /Codon_Change="CAG -> CGG" /Coverage=104 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="9e-228" /Variant_Raw_Frequency=101 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1902286,1902288) /Source="geneious" /ID="SNP_BsPG10_2374714_2374714" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="D -> N" /CDS_Position=175 /Change="C -> T" /Codon_Change="GAT -> AAT" /Coverage=95 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency="1.1%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="2.8e-220" /Variant_Raw_Frequency=93 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1902314,1902316) /Source="geneious" /ID="SNP_BsPG10_2374742_2374742" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=147 /Change="T -> C" /Codon_Change="GCA -> GCG" /Coverage=98 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.2e-260" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1902329,1902331) /Source="geneious" /ID="SNP_BsPG10_2374757_2374757" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=132 /Change="G -> A" /Codon_Change="GCC -> GCT" /Coverage=197 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value /Variant_Raw_Frequency /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1902354,1902356) /Source="geneious" /ID="SNP_BsPG10_2374782_2374782" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="P -> L" /CDS_Position=107 /Change="G -> A" /Codon_Change="CCG -> CTG" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value=0 /Variant_Raw_Frequency=118 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1902371,1902373) /Source="geneious" /ID="SNP_BsPG10_2374799_2374799" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=90 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=133 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=131 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(1902386,1902388) /Source="geneious" /ID="SNP_BsPG10_2374814_2374814" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=75 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=130 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=130 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" CDS complement(1902454..1903470) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /modified_by="User" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" /label="trpD CDS" gene complement(1902454..1903470) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /modified_by="User" /label="trpD gene" CDS complement(1903442..1904989) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" /label="trpE CDS" gene complement(1903442..1904989) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /label="trpE gene" S_feature complement(1905068..1905199) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(1905111) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1905190..1905209) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(1905199) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" CDS complement(1905205..1905588) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" /label="aroH CDS" gene complement(1905205..1905588) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /label="aroH gene" promotor_-35 complement(1905224..1905231) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(1905585..1906673) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" /label="aroB CDS" gene complement(1905585..1906673) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /label="aroB gene" promotor_-10 complement(1905714..1905729) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1905727) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1905742..1905750) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1906673..1907845) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" /label="aroF CDS" gene complement(1906673..1907845) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /label="aroF gene" promotor_-10 complement(1907880..1907899) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1907897) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1907912..1907919) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1907920..1908690) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" /label="cheR CDS" gene complement(1907920..1908690) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /label="cheR gene" promotor_-10 complement(1908716..1908735) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1908733) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1908747..1908753) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(1908765..1908926) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(1908808) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" CDS complement(1908927..1909376) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" /label="ndk CDS" gene complement(1908927..1909376) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /label="ndk gene" promotor_-10 complement(1909419..1909438) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(1909426) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(1909451..1909458) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(1909492..1910538) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" /label="hepT CDS" gene complement(1909492..1910538) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /label="hepT gene" CDS complement(1910480..1911181) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" /label="menG CDS" gene complement(1910480..1911181) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /label="menG gene" CDS complement(1911188..1911943) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" /label="hepS CDS" gene complement(1911188..1911943) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /label="hepS gene" S_feature complement(1911944..1912029) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(1912018..1912037) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1912029) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1912048..1912055) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1912107..1912334) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" /label="mtrB CDS" gene complement(1912107..1912334) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /label="mtrB gene" downshifts complement(1912128) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" /label="downshifts" CDS complement(1912356..1912928) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" /label="folEA CDS" gene complement(1912356..1912928) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /label="folEA gene" promotor_-10 complement(1912957..1912976) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1912967) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" S_feature complement(1912969..1913052) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(1912989..1912995) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(1913097) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" /label="downshifts" CDS complement(1913116..1913394) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" /label="hbs CDS" gene complement(1913116..1913394) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /label="hbs gene" S_feature complement(1913395..1913620) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(1913602..1913621) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(1913620) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(1913638..1913643) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(1913768..1915246) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" /label="spoIVA CDS" gene complement(1913768..1915246) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /label="spoIVA gene" downshifts complement(1913781) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1915247..1915408) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(1915395..1915413) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(1915420) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="upshifts" CDS complement(1915427..1916161) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" /label="yphF CDS" gene complement(1915427..1916161) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /label="yphF gene" promotor_-35 complement(1915428..1915433) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(1915453) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" /label="downshifts" CDS complement(1916183..1916386) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" /label="yphE CDS" gene complement(1916183..1916386) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /label="yphE gene" promotor_-10 complement(1916422..1916441) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1916443) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1916455..1916462) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1916508..1916707) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(1916551) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1916682..1916701) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1916707) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1916715..1916724) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1916724..1917761) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" /label="gpsA CDS" gene complement(1916724..1917761) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /label="gpsA gene" CDS complement(1917779..1919089) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" /label="der CDS" gene complement(1917779..1919089) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /label="der gene" S_feature complement(1919090..1919214) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(1919200..1919219) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1919214) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1919234..1919237) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1919243..1919437) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" /label="ypzH CDS" gene complement(1919243..1919437) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /label="ypzH gene" CDS complement(1919434..1920327) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" /label="yphB CDS" gene complement(1919434..1920327) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /label="yphB gene" CDS complement(1920324..1920923) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" /label="yphA CDS" gene complement(1920324..1920923) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /label="yphA gene" promotor_-35 1920796..1920802 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1920811..1920994 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 1920813 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1920816..1920827 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1920934..1920952) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1920953) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1920968..1920973) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1921001..1921132 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " /label="ypzI CDS" gene 1921001..1921132 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /label="ypzI gene" downshifts 1921120 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1921175..1922224) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" /label="fni CDS" gene complement(1921175..1922224) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /label="fni gene" downshifts complement(1921195) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1922099) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" /label="downshifts" CDS complement(1922237..1923385) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" /label="rpfA CDS" gene complement(1922237..1923385) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /label="rpfA gene" misc_feature 1922566..1922569 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1922593 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1922659 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1923363 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" /label="downshifts" S_feature complement(1923386..1923525) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(1923524..1923543) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1923525) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1923527..1923617) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(1923558..1923565) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1923618..1924292) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" /label="cmk CDS" gene complement(1923618..1924292) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /label="cmk gene" S_feature complement(1924293..1924370) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(1924371..1924547) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" /label="ypfB CDS" gene complement(1924371..1924547) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /label="ypfB gene" promotor_-10 complement(1924559..1924577) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1924576) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1924592..1924598) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1924592..1925245) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " /label="dgrA CDS" gene complement(1924592..1925245) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /label="dgrA gene" promotor_-10 complement(1925275..1925294) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1925288) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1925310..1925314) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1925338..1926690) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" /label="sleC CDS" gene complement(1925338..1926690) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /label="sleC gene" downshifts complement(1925353) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1926725..1927642) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" /label="sleB CDS" gene complement(1926725..1927642) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /label="sleB gene" downshifts complement(1927113) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" /label="downshifts" misc_feature complement(1927264..1927271) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1927267) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1927680..1927691) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1927689) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1927705..1927711) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1927781..1928437) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" /label="prsW CDS" gene complement(1927781..1928437) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /label="prsW gene" downshifts complement(1927795) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1928462..1928481) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1928477) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1928557..1929531) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" /label="ypdA CDS" gene complement(1928557..1929531) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /label="ypdA gene" downshifts complement(1928565) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-35 1929385..1929390 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1929406..1929424 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1929416..1929609 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 1929416 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="upshifts" downshifts 1929567 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1929640..1930923) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" /label="gudB CDS" gene complement(1929640..1930923) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /label="gudB gene" downshifts complement(1929643) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" /label="downshifts" promotor_-35 1929681..1929687 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1929699..1929703 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1929699 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1930966..1930985) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1930987) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1931000..1931007) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1931079..1931663) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" /label="mecB CDS" gene complement(1931079..1931663) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /label="mecB gene" downshifts complement(1931081) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" /label="downshifts" S_feature complement(1931664..1931745) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(1931738..1931757) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(1931745) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="upshifts" promotor_-35 complement(1931771..1931778) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(1931822..1932601) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" /label="ypbG CDS" gene complement(1931822..1932601) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /label="ypbG gene" promotor_-10 complement(1932627..1932642) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(1932638) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="upshifts" promotor_-35 complement(1932654..1932663) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(1932687..1933130) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" /label="ypbF CDS" gene complement(1932687..1933130) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /label="ypbF gene" downshifts complement(1932704) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1933193..1933915) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" /label="ypbE CDS" gene complement(1933193..1933915) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /label="ypbE gene" downshifts complement(1933474) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" CDS complement(1933866..1934435) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" /label="ypbD CDS" gene complement(1933866..1934435) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /label="ypbD gene" promotor_-10 complement(1934184..1934202) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1934200) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1934217..1934223) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1934454..1935200 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(1934495..1935985) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" /label="recS CDS" gene complement(1934495..1935985) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /label="recS gene" CDS complement(1935978..1937036) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" /label="gmmB CDS" gene complement(1935978..1937036) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /label="gmmB gene" promotor_-35 1936326..1936335 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1936346..1937136 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 1936346 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1936348..1936367 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1937077..1937096) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1937100) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1937108..1937115) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1937114..1937120 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 1937134..1937153 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 1937138..1937207 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 1937138 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="upshifts" promotor_-35 1937187..1937194 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1937209..1937301 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 1937209..1937228 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1937209 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="upshifts" CDS 1937302..1937550 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" /label="fer CDS" gene 1937302..1937550 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /label="fer gene" downshifts 1937534 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1937590..1938162) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" /label="fmnP CDS" gene complement(1937590..1938162) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /label="fmnP gene" downshifts complement(1937610) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(1938154..1938461) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" /label="fswB RNA" gene complement(1938154..1938461) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /label="fswB gene" S_feature complement(1938163..1938267) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(1938460..1938479) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1938476) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1938493..1938499) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1938588..1938595 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1938606 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1938610..1938629 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1938659..1940236 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" /label="serA CDS" gene 1938659..1940236 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /label="serA gene" downshifts 1940218 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(1940279..1941046) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" /label="aroC CDS" gene complement(1940279..1941046) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /label="aroC gene" downshifts complement(1940294) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1940548..1941160 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(1941073..1941092) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1941086) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1941107..1941110) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1941120 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS complement(1941158..1942264) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" /label="rsiX CDS" gene complement(1941158..1942264) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /label="rsiX gene" downshifts complement(1941175) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" /label="downshifts" CDS complement(1942200..1942784) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" /label="sigX CDS" gene complement(1942200..1942784) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /label="sigX gene" promotor_-35 1942578..1942583 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1942594 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1942598..1942602 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1942735..1942740 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1942752 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1942756..1942774 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1942792 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1942833..1942852) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1942837..1942944 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(1942841) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1942865..1942872) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1942900 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(1942929..1942987) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(1942960) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1942988..1944757) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" /label="resE CDS" gene complement(1942988..1944757) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /label="resE gene" downshifts complement(1943044) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(1944754..1945476) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" /label="resD CDS" gene complement(1944754..1945476) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /label="resD gene" S_feature complement(1945477..1945556) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(1945557..1946732) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " /label="resC CDS" gene complement(1945557..1946732) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /label="resC gene" CDS complement(1946752..1948380) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" /label="resB CDS" gene complement(1946752..1948380) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /label="resB gene" CDS complement(1948377..1948916) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" /label="resA CDS" gene complement(1948377..1948916) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /label="resA gene" S_feature complement(1948917..1949010) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(1949011..1949745) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" /label="rluB CDS" gene complement(1949011..1949745) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /label="rluB gene" promotor_-10 complement(1949754..1949773) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1949777) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1949788..1949792) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1949837..1950373) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" /label="spmB CDS" gene complement(1949837..1950373) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /label="spmB gene" promotor_-10 complement(1949842..1949861) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1949846) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1949876..1949883) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1950378..1950968) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" /label="spmA CDS" gene complement(1950378..1950968) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /label="spmA gene" CDS complement(1950956..1952104) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" /label="dacB CDS" gene complement(1950956..1952104) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /label="dacB gene" promotor_-10 complement(1952126..1952144) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1952133) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1952159..1952164) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1952227..1952766) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" /label="ypuI CDS" gene complement(1952227..1952766) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /label="ypuI gene" downshifts complement(1952240) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1952775..1952792) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1952790) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1952807..1952812) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1952821..1953414) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" /label="spcB CDS" gene complement(1952821..1953414) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /label="spcB gene" CDS complement(1953404..1954159) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" /label="scpA CDS" gene complement(1953404..1954159) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /label="scpA gene" promotor_-35 1954003..1954012 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1954025..1954044 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1954034 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1954205..1954224) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1954220) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1954238..1954245) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1954385..1954392 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1954403..1954422 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1954408 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="upshifts" CDS 1954440..1954964 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" /label="ypuF CDS" gene 1954440..1954964 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /label="ypuF gene" CDS complement(1954978..1955352) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" /label="ypzK CDS" gene complement(1954978..1955352) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /label="ypzK gene" downshifts complement(1954994) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1955414..1955433) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1955426) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1955445..1955452) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1955465..1955929) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" /label="ribH CDS" gene complement(1955465..1955929) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /label="ribH gene" promotor_-35 1955800..1955804 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1955818..1955822 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1955821 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1955962..1957158) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" /label="ribBA CDS" gene complement(1955962..1957158) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /label="ribBA gene" CDS complement(1957173..1957820) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" /label="ribE CDS" gene complement(1957173..1957820) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /label="ribE gene" CDS complement(1957831..1958916) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" /label="ribD CDS" gene complement(1957831..1958916) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /label="ribD gene" S_feature complement(1958917..1959045) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(1959046..1959190) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" /label="fswA RNA" gene complement(1959046..1959190) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /label="fswA gene" promotor_-10 complement(1959207..1959226) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1959217) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1959241..1959248) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1959310..1959654) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" /label="ypuD CDS" gene complement(1959310..1959654) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /label="ypuD gene" downshifts complement(1959325) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1959686..1959704) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1959699) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1959713..1959718 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1959719..1959725) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1959733..1960655 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 1959733 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1959734..1959752 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1959740..1959755) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1959743) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1959745..1959811) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(1959768..1959777) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1959806..1959814) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1959811) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1959828..1959836) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1959889..1960443) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" /label="sipS CDS" gene complement(1959889..1960443) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /label="sipS gene" downshifts complement(1959899) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1960469..1960488) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1960487) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1960489..1960888) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(1960500..1960506) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1960710..1960946 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" /label="ypzC CDS" gene 1960710..1960946 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /label="ypzC gene" CDS complement(1960889..1961095) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" /label="ypzJ CDS" gene complement(1960889..1961095) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /label="ypzJ gene" misc_feature complement(1961128..1961147) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1961150) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="upshifts" CDS complement(1961204..1961458) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" /label="ypuC CDS" gene complement(1961204..1961458) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo /label="ypuC gene" promotor_-35 1961338..1961347 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1961349..1961738) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" /label="ypuC CDS" gene complement(1961349..1961738) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo /label="ypuC gene" S_feature 1961361..1962432 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 1961361..1961380 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1961361 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1961716..1961919) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" /label="ypuB CDS" gene complement(1961716..1961919) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /label="ypuB gene" CDS 1962328..1962444 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" /label="hypothetical protein CDS" gene 1962328..1962444 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo /label="gene" downshifts 1962395 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" /label="downshifts" promotor_-35 1962521..1962530 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1962543..1962562 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1962543 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1962585..1962797 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" /label="ypzD CDS" gene 1962585..1962797 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /label="ypzD gene" downshifts 1962791 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" downshifts complement(1962933) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1962933..1963364) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" /label="ppiB CDS" gene complement(1962933..1963364) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /label="ppiB gene" S_feature complement(1963365..1963451) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(1963434..1963453) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1963451) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1963467..1963472) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1963501..1963510 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1963520..1963617 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 1963520 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1963523..1963538 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1963618..1964490 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" /label="ypuA CDS" gene 1963618..1964490 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /label="ypuA gene" downshifts 1964397 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 1964463 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1964520..1965839) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" /label="lysA CDS" gene complement(1964520..1965839) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /label="lysA gene" downshifts complement(1964540) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1965840..1965904) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(1965900..1965919) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1965904) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1965934..1965941) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1965945..1966563) /gene="spoVAF" /locus_tag="PG10_5'_ext_BSU_23390" /old_locus_tag="BSU_23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /modified_by="User" /translation="MTTSSGKIFRYSCFYFISSDLVSLCASA*SAPGQHEIYRFK*RY AYPDHPADIFS*LRNRVSQNGCHSHTDGFIDSNGFNCRCSDRADCD*GRPFFS*GDSV RLTCGDWNLYDA*L*IKLGKQNEPSCPHDTRCFISYKRARHRIYSANYCHGKHQIPSD TVLMAADSL*RKGAVAGSCPHSETWRKSKTQHRSPQKSLKAAYQFI" /label="PG10_5'_ext_BSU_23390" gene complement(1965945..1966563) /gene="PG10_5'_ext_BSU_23390" /locus_tag="PG10_pseudo_BSU_23390" /old_locus_tag="BSU_23390" /modified_by="User" /label="PG10_5'_ext_BSU_23390" SCAR join(1966549,1966556) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs23" N_region 1966550..1966555 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs23" S_feature complement(<1966556..1966572) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" CDS complement(1966573..1967742) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" /label="dacF CDS" gene complement(1966573..1967742) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /label="dacF gene" promotor_-10 complement(1967771..1967782) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1967786) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1967796..1967802) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1967888) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1967897..1968712) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" /label="pupG CDS" gene complement(1967897..1968712) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /label="pupG gene" CDS complement(1968725..1969909) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" /label="deoB CDS" gene complement(1968725..1969909) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /label="deoB gene" promotor_-10 complement(1969958..1969977) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1969976) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1969978..1970069) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(1969993..1970000) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1970070..1970960) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" /label="ripX CDS" gene complement(1970070..1970960) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /label="ripX gene" CDS complement(1970968..1971195) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" /label="yqzK CDS" gene complement(1970968..1971195) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /label="yqzK gene" promotor_-10 complement(1971098..1971117) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1971109) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1971131..1971138) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1971188) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1971197..1971215) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1971225..1971243) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1971231..1971237) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1971238) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1971260..1971265) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1971320) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" /label="downshifts" CDS complement(1971320..1971769) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" /label="fur CDS" gene complement(1971320..1971769) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /label="fur gene" promotor_-10 complement(1971793..1971812) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(1971803) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="upshifts" S_feature complement(1971805..1971881) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(1971828..1971832) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(1971882..1972526) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" /label="spoIIM CDS" gene complement(1971882..1972526) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /label="spoIIM gene" promotor_-10 complement(1972557..1972575) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(1972574) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="upshifts" promotor_-35 complement(1972590..1972595) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(1972627..1972842) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" /label="yqkK CDS" gene complement(1972627..1972842) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /label="yqkK gene" downshifts complement(1972707) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1972942..1974261) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" /label="mleA CDS" gene complement(1972942..1974261) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /label="mleA gene" downshifts complement(1972949) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" CDS complement(1974279..1975685) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" /label="mleN CDS" gene complement(1974279..1975685) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /label="mleN gene" promotor_-10 complement(1975733..1975752) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1975742) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1975744..1975825) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(1975767..1975774) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1975826..1977253) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" /label="ansB CDS" gene complement(1975826..1977253) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /label="ansB gene" CDS complement(1977298..1978287) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" /label="ansA CDS" gene complement(1977298..1978287) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /label="ansA gene" S_feature complement(1978288..1978367) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(1978349..1978368) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1978367) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1978369..1978689) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(1978383..1978390) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1978408..1978415 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1978428..1978447 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1978430 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="upshifts" CDS 1978469..1978819 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" /label="ansR CDS" gene 1978469..1978819 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /label="ansR gene" S_feature complement(1978691..1978827) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(1978734) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" /label="downshifts" CDS complement(1978828..1979991) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" /label="yqxK CDS" gene complement(1978828..1979991) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /label="yqxK gene" CDS complement(1979988..1980545) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" /label="nudF CDS" gene complement(1979988..1980545) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /label="nudF gene" promotor_no_box complement(1980475..1980575) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1980515) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1980559..1980564 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1980580..1980598 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1980582..1980596) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 1980586 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="upshifts" S_feature 1980593..1980767 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(1980598..1980601) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(1980601) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="upshifts" CDS 1980620..1980742 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" /label="mciZ CDS" gene 1980620..1980742 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /label="mciZ gene" promotor_-35 1980743..1980750 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1980764..1980783 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1980769 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="upshifts" CDS 1980805..1981725 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" /label="yqkF CDS" gene 1980805..1981725 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /label="yqkF gene" downshifts 1981714 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1981757..1981981) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" /label="yqkE CDS" gene complement(1981757..1981981) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /label="yqkE gene" downshifts complement(1981814) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1982004..1982023) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1982011) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1982038..1982045) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1982060..1982067 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1982082..1982101 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1982089 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="upshifts" CDS 1982143..1983060 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" /label="yqkD CDS" gene 1982143..1983060 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /label="yqkD gene" downshifts 1983035 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" /label="downshifts" CDS complement(1983100..1983339) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" /label="yqkC CDS" gene complement(1983100..1983339) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /label="yqkC gene" downshifts complement(1983111) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1983352..1983675) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" /label="yqkB CDS" gene complement(1983352..1983675) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /label="yqkB gene" promotor_-10 complement(1983418..1983437) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1983419) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1983451..1983458) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1983672..1984703) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" /label="yqkA CDS" gene complement(1983672..1984703) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /label="yqkA gene" promotor_-10 complement(1983699..1983718) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1983706) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1983729..1983736) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1984696..1985040) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" /label="yqjZ CDS" gene complement(1984696..1985040) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /label="yqjZ gene" CDS complement(1985050..1985520) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" /label="yqjY CDS" gene complement(1985050..1985520) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /label="yqjY gene" S_feature complement(1985521..1985597) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 1985521 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1985572..1985591) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1985597) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1985599..1985705) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(1985606..1985613) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1985706..1986044) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" /label="yqjX CDS" gene complement(1985706..1986044) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /label="yqjX gene" CDS complement(1986041..1987279) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" /label="polYB CDS" gene complement(1986041..1987279) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /label="polYB gene" misc_feature 1986203..1986204 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1986214 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1986269 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1987304..1987322) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(1987313) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="upshifts" promotor_-35 complement(1987339..1987344) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 1987384..1987387 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1987402..1987421 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1987411 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="upshifts" CDS 1987445..1987651 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" /label="yqzH CDS" gene 1987445..1987651 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /label="yqzH gene" promotor_-35 1988134..1988137 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1988152..1988171 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1988168 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="upshifts" CDS 1988200..1989432 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" /label="yqjV CDS" gene 1988200..1989432 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /label="yqjV gene" CDS 1989279..1989641 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" /label="yqjU CDS" gene 1989279..1989641 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /label="yqjU gene" S_feature complement(1989458..1989637) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(1989491) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1989638..1990024) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" /label="yqjT CDS" gene complement(1989638..1990024) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /label="yqjT gene" CDS complement(1990028..1990987) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" /label="coaA CDS" gene complement(1990028..1990987) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /label="coaA gene" S_feature complement(1990988..1991058) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(1991059..1992405) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" /label="dsdA CDS" gene complement(1991059..1992405) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /label="dsdA gene" S_feature complement(1992406..1992480) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(1992481..1993260) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" /label="yqjQ CDS" gene complement(1992481..1993260) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /label="yqjQ gene" CDS complement(1993266..1994225) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" /label="yqjP CDS" gene complement(1993266..1994225) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /label="yqjP gene" promotor_-10 complement(1994247..1994266) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1994266) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1994281..1994288) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1994322..1994329 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1994343..1994629 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 1994343 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1994345..1994364 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1994359..1994604 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" /label="pswI RNA" gene 1994359..1994604 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /label="pswI gene" CDS 1994630..1995466 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" /label="proI CDS" gene 1994630..1995466 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /label="proI gene" downshifts 1995464 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1995507..1997150) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" /label="yqjN CDS" gene complement(1995507..1997150) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /label="yqjN gene" downshifts complement(1995519) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1997168..1997174 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1997181 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1997188..1997199 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(1997206..1997225) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1997211) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1997257..1997264 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1997278..1997297 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1997280 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 1997322..1998338 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" /label="yqjM CDS" gene 1997322..1998338 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /label="yqjM gene" downshifts 1998325 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 1998387..1998396 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1998409..1998424 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1998413 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 1998448..1999209 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" /label="yqjL CDS" gene 1998448..1999209 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /label="yqjL gene" downshifts 1999117 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 1999205 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1999237..1999437) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(1999253..1999378) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" /label="rpmGCc CDS" gene complement(1999253..1999378) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo /label="rpmGCc gene" downshifts complement(1999280) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1999371..1999403) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" /label="rpmGCn CDS" gene complement(1999371..1999403) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo /label="rpmGCn gene" promotor_-10 complement(1999431..1999450) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1999437) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1999463..1999470) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1999485..2000408) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" /label="rnz CDS" gene complement(1999485..2000408) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /label="rnz gene" promotor_-10 complement(2000434..2000453) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2000447) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2000467..2000472) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2000546..2000553 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2000567..2000586 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2000569..2000634 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 2000569 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="upshifts" CDS 2000635..2002104 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" /label="zwf CDS" gene 2000635..2002104 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /label="zwf gene" downshifts 2002087 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" terminator 2002112..2002151 /created_by="User" /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" /label="Delta6_zwf-T-gndA_Terminator" Polymorphism join(2002124,2002127) /Source="geneious" /ID="SNP_BsDelta6_2480646_2480647" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="TA -> AT" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TA" /Variant_Nucleotides="AT" /Variant_P_Value=0 /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2002132,2002133) /Source="geneious" /ID="SNP_BsDelta6_2480654_2480654" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.1e-279" /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2002144,2002145) /Source="geneious" /ID="SNP_BsDelta6_2480667_2480667" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=116 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.9e-244" /Variant_Raw_Frequency=110 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2002153 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2002227..2003636) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" /label="gndA CDS" gene complement(2002227..2003636) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /label="gndA gene" downshifts complement(2002244) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" downshifts complement(2002317) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" misc_feature complement(2003700..2003718) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2003702) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2003746..2004990) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" /label="polYA CDS" gene complement(2003746..2004990) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /label="polYA gene" S_feature complement(2004991..2005265) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 2005011..2005018 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2005032..2005051 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2005032 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="upshifts" CDS 2005063..2005350 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" /label="mifM CDS" gene 2005063..2005350 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /label="mifM gene" promotor_-10 complement(2005247..2005266) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(2005267) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="upshifts" promotor_-35 complement(2005282..2005285) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 2005381..2006208 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " /label="oxaAB CDS" gene 2005381..2006208 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /label="oxaAB gene" downshifts 2006025 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2006201 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2006213..2007133) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(2006256) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2006326..2006332 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2006346..2006364 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2006355 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="upshifts" CDS 2006388..2007116 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" /label="yqjF CDS" gene 2006388..2007116 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /label="yqjF gene" CDS complement(2007157..2008272) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" /label="yqjE CDS" gene complement(2007157..2008272) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /label="yqjE gene" downshifts complement(2007178) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" CDS complement(2008290..2009813) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " /label="yqjD CDS" gene complement(2008290..2009813) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /label="yqjD gene" promotor_-10 complement(2009396..2009415) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2009418) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2009430..2009434) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2009806..2010228) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" /label="yqjC CDS" gene complement(2009806..2010228) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /label="yqjC gene" promotor_-35 2010257..2010264 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2010278..2010297 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2010292..2010445 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 2010292 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="upshifts" downshifts 2010402 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" CDS complement(2010430..2010960) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" /label="yqjB CDS" gene complement(2010430..2010960) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /label="yqjB gene" S_feature 2010447..2011082 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(2010977..2010988) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2010984) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2011003..2011009) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2011012..2011980) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" /label="yqjA CDS" gene complement(2011012..2011980) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /label="yqjA gene" downshifts complement(2011028) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2012051..2012773) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" /label="artR CDS" gene complement(2012051..2012773) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /label="artR gene" downshifts complement(2012062) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS complement(2012766..2013425) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" /label="artQ CDS" gene complement(2012766..2013425) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /label="artQ gene" S_feature complement(2013426..2013505) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(2013506..2014273) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" /label="artP CDS" gene complement(2013506..2014273) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /label="artP gene" promotor_-10 complement(2014323..2014342) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2014338) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2014357..2014364) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2014541..2014978) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" /label="brxB CDS" gene complement(2014541..2014978) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /label="brxB gene" downshifts complement(2014550) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2015002..2015021) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(2015023) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="upshifts" promotor_-35 complement(2015036..2015043) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 2015076..2015082 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2015095 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2015097..2015115 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2015139..2016032 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" /label="bmrU CDS" gene 2015139..2016032 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /label="bmrU gene" promotor_-35 2016065..2016072 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2016088..2016107 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2016096 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" CDS 2016133..2017302 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" /label="bmr CDS" gene 2016133..2017302 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /label="bmr gene" downshifts 2017285 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" CDS 2017375..2018211 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" /label="bmrR CDS" gene 2017375..2018211 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /label="bmrR gene" downshifts 2018209 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2018273) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2018273..2019547) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" /label="bkdB CDS" gene complement(2018273..2019547) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /label="bkdB gene" CDS complement(2019570..2020553) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" /label="bkdAB CDS" gene complement(2019570..2020553) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /label="bkdAB gene" CDS complement(2020567..2021559) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" /label="bkdAA CDS" gene complement(2020567..2021559) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /label="bkdAA gene" CDS complement(2021581..2023005) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" /label="lpdV CDS" gene complement(2021581..2023005) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /label="lpdV gene" CDS complement(2023026..2024117) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" /label="buk CDS" gene complement(2023026..2024117) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /label="buk gene" CDS complement(2024136..2025230) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" /label="bcd CDS" gene complement(2024136..2025230) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /label="bcd gene" CDS complement(2025242..2026141) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" /label="ptb CDS" gene complement(2025242..2026141) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /label="ptb gene" misc_feature complement(2026177..2026196) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2026182) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2026184..2026265) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2026266..2028344) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" /label="bkdR CDS" gene complement(2026266..2028344) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /label="bkdR gene" promotor_-10 complement(2028404..2028423) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2028421) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2028431..2028438 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2028440..2028443) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2028452..2028471 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2028459 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="upshifts" CDS 2028497..2028733 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" /label="yqzF CDS" gene 2028497..2028733 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /label="yqzF gene" downshifts 2028724 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2028775..2029680) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" /label="mmgF CDS" gene complement(2028775..2029680) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /label="mmgF gene" downshifts complement(2028778) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2029698..2031116) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" /label="mmgE CDS" gene complement(2029698..2031116) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /label="mmgE gene" misc_feature complement(2029993..2030012) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2030010) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2031131..2032249) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" /label="mmgD CDS" gene complement(2031131..2032249) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /label="mmgD gene" CDS complement(2032283..2033422) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" /label="mmgC CDS" gene complement(2032283..2033422) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /label="mmgC gene" CDS complement(2033450..2034313) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" /label="mmgB CDS" gene complement(2033450..2034313) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /label="mmgB gene" CDS complement(2034338..2035519) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" /label="mmgA CDS" gene complement(2034338..2035519) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /label="mmgA gene" downshifts complement(2035099) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" /label="downshifts" misc_feature complement(2035206..2035212) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2035209) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2035433..2035533) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2035473) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2035566..2035584) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2035584) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2035600..2035605) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2035646..2036377) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" /label="glpQ CDS" gene complement(2035646..2036377) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /label="glpQ gene" downshifts complement(2035653) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2036400..2036419) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2036411) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2036434..2036437) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2036456..2037076) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" /label="yqiI CDS" gene complement(2036456..2037076) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /label="yqiI gene" CDS complement(2037091..2037384) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" /label="yqiH CDS" gene complement(2037091..2037384) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /label="yqiH gene" promotor_-10 complement(2037404..2037423) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2037410) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2037438..2037445) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2037640..2037647 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2037661..2037680 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2037678..2037883 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2037678 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2037692..2037844 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" /label="hypothetical protein CDS" gene 2037692..2037844 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /label="gene" promotor_-35 2037852..2037859 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2037874..2037893 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2037885 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2037917..2039035 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" /label="yqiG CDS" gene 2037917..2039035 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /label="yqiG gene" downshifts 2039020 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2039062..2039232) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2039105) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2039216..2039231) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2039232) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2039234..2039362) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2039243..2039252) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2039361..2039380) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2039384) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2039394..2039402) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2039494) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2039500..2040303) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" /label="spo0A CDS" gene complement(2039500..2040303) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /label="spo0A gene" promotor_-10 complement(2040346..2040364) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2040352) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2040354..2040506) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2040375..2040383) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2040502..2040521) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2040514) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2040533..2040540) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 2040548..2040549 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_005" CDS complement(2040609..2042339) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" /label="recN CDS" gene complement(2040609..2042339) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /label="recN gene" downshifts complement(2040624) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2042376..2042825) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" /label="argR CDS" gene complement(2042376..2042825) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /label="argR gene" S_feature complement(2042826..2042911) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2042923..2043768) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" /label="yqxC CDS" gene complement(2042923..2043768) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /label="yqxC gene" downshifts complement(2042956) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" /label="downshifts" CDS complement(2043765..2045666) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" /label="dxs CDS" gene complement(2043765..2045666) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /label="dxs gene" promotor_-35 2044874..2044880 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2044895..2044906 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2044903 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2045667..2045795) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2045790..2045809) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2045795) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2045824..2045830) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2045841..2046731) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" /label="ispA CDS" gene complement(2045841..2046731) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /label="ispA gene" CDS complement(2046721..2046975) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" /label="xseB CDS" gene complement(2046721..2046975) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /label="xseB gene" CDS complement(2046972..2048318) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" /label="xseA CDS" gene complement(2046972..2048318) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /label="xseA gene" S_feature complement(2048319..2048455) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2048456..2049307) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" /label="folD CDS" gene complement(2048456..2049307) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /label="folD gene" CDS complement(2049319..2049714) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" /label="nusB CDS" gene complement(2049319..2049714) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /label="nusB gene" misc_feature complement(2049757..2049776) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2049776) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2049778..2049940) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2049978..2050385) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" /label="yqhY CDS" gene complement(2049978..2050385) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /label="yqhY gene" downshifts complement(2049985) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" /label="downshifts" CDS complement(2050406..2051758) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" /label="accC CDS" gene complement(2050406..2051758) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /label="accC gene" promotor_-10 complement(2051287..2051306) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2051294) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="upshifts" promotor_-35 complement(2051321..2051327) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2051770..2052249) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " /label="accB CDS" gene complement(2051770..2052249) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /label="accB gene" promotor_-10 complement(2052308..2052327) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2052319) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2052341..2052348) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2052405..2053061) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" /label="spoIIIAH CDS" gene complement(2052405..2053061) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /label="spoIIIAH gene" downshifts complement(2052412) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" CDS complement(2053062..2053751) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" /label="spoIIIAG CDS" gene complement(2053062..2053751) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /label="spoIIIAG gene" CDS complement(2053744..2054364) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" /label="spoIIIAF CDS" gene complement(2053744..2054364) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /label="spoIIIAF gene" promotor_-10 complement(2054070..2054088) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2054088) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2054104..2054109) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2054378..2055577) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" /label="spoIIIAE CDS" gene complement(2054378..2055577) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /label="spoIIIAE gene" CDS complement(2055596..2055997) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" /label="spoIIIAD CDS" gene complement(2055596..2055997) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /label="spoIIIAD gene" CDS complement(2056004..2056210) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" /label="spoIIIAC CDS" gene complement(2056004..2056210) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /label="spoIIIAC gene" CDS complement(2056233..2056748) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" /label="spoIIIAB CDS" gene complement(2056233..2056748) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /label="spoIIIAB gene" CDS complement(2056742..2057665) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" /label="spoIIIAA CDS" gene complement(2056742..2057665) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /label="spoIIIAA gene" S_feature complement(2057666..2057740) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2057741..2058022) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" /label="yqhV CDS" gene complement(2057741..2058022) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /label="yqhV gene" promotor_-10 complement(2058042..2058060) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2058065) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="upshifts" promotor_-35 complement(2058076..2058081) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2058167..2058724) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" /label="efp CDS" gene complement(2058167..2058724) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /label="efp gene" downshifts complement(2058179) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2058749..2059810) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" /label="papA CDS" gene complement(2058749..2059810) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /label="papA gene" CDS complement(2059807..2060253) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" /label="yqhS CDS" gene complement(2059807..2060253) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /label="yqhS gene" promotor_-10 complement(2060302..2060321) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2060318) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2060334..2060341) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2060340..2060876) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" /label="yqhR CDS" gene complement(2060340..2060876) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /label="yqhR gene" promotor_-10 complement(2060889..2060900) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2060898) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="upshifts" promotor_-35 complement(2060914..2060920) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2060946..2060952 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2060965 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2060967..2060985 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2061022..2061025 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2061040..2061059 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2061051 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" CDS 2061103..2062059 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" /label="yqhQ CDS" gene 2061103..2062059 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /label="yqhQ gene" CDS 2062099..2062494 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" /label="yqhP CDS" gene 2062099..2062494 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /label="yqhP gene" promotor_no_box 2062377..2062477 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2062437 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2062480 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2062491..2063366) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" /label="yqhO CDS" gene complement(2062491..2063366) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /label="yqhO gene" promotor_-10 complement(2063393..2063411) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2063410) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2063427..2063432) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2063492..2063920) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" /label="mntR CDS" gene complement(2063492..2063920) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /label="mntR gene" downshifts complement(2063519) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2063955..2063974) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2063963) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2063990..2063994) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2064020..2064856) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" /label="lipM CDS" gene complement(2064020..2064856) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /label="lipM gene" promotor_-10 complement(2064880..2064899) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2064891) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2064893..2065437) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2064913..2064920) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2064937..2064942 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2064956..2064975 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2064956 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="upshifts" S_feature 2064967..2065046 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2065047..2065427 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" /label="yqhL CDS" gene 2065047..2065427 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /label="yqhL gene" downshifts 2065363 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2065407 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2065462..2066928) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" /label="gcvPB CDS" gene complement(2065462..2066928) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /label="gcvPB gene" downshifts complement(2065482) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" /label="downshifts" CDS complement(2066921..2068267) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" /label="gcvPA CDS" gene complement(2066921..2068267) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /label="gcvPA gene" CDS complement(2068297..2069385) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" /label="gcvT CDS" gene complement(2068297..2069385) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /label="gcvT gene" misc_RNA complement(2069459..2069658) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" /label="swgA RNA" gene complement(2069459..2069658) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /label="swgA gene" downshifts complement(2069509) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" /label="downshifts" S_feature complement(2069659..2069729) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2069662..2069667 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2069683..2069701 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2069687 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2069697..2069826 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2069715..2069734) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2069729) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="upshifts" promotor_-35 complement(2069748..2069755) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2069827..2071500 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" /label="yqhH CDS" gene 2069827..2071500 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /label="yqhH gene" CDS 2071521..2072315 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" /label="yqhG CDS" gene 2071521..2072315 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /label="yqhG gene" misc_feature 2071851..2071852 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2071857 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="upshifts" promotor_-35 2072339..2072342 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2072358..2072377 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2072359..2072497 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2072359 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2072498..2072671 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" /label="sinI CDS" gene 2072498..2072671 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /label="sinI gene" promotor_-35 2072656..2072660 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2072673..2072692 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2072673 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2072705..2073040 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" /label="sinR CDS" gene 2072705..2073040 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /label="sinR gene" downshifts 2073017 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts 2073107 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts complement(2073139) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2073156,2073163) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs27" N_region 2073157..2073162 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs27" promotor_-35 2073232..2073238 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2073239 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2073252..2073263 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2073282..2073608 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" /label="yqzG CDS" gene 2073282..2073608 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /label="yqzG gene" S_feature complement(2073425..2073649) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2073468) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2073590 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2073650..2073829) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" /label="spoIIT CDS" gene complement(2073650..2073829) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /label="spoIIT gene" promotor_-10 complement(2073848..2073866) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2073863) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2073881..2073887) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2073900..2074274) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" /label="comGG CDS" gene complement(2073900..2074274) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /label="comGG gene" CDS complement(2074275..2074658) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" /label="comGF CDS" gene complement(2074275..2074658) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /label="comGF gene" CDS complement(2074684..2075031) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" /label="comGE CDS" gene complement(2074684..2075031) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /label="comGE gene" CDS complement(2075015..2075446) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" /label="comGD CDS" gene complement(2075015..2075446) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /label="comGD gene" CDS complement(2075436..2075732) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" /label="comGC CDS" gene complement(2075436..2075732) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /label="comGC gene" CDS complement(2075746..2076717) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" /label="comGB CDS" gene complement(2075746..2076717) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /label="comGB gene" CDS complement(2076770..2077840) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" /label="comGA CDS" gene complement(2076770..2077840) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /label="comGA gene" promotor_-10 complement(2077858..2077877) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2077874) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2077891..2077898) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2078023..2078251) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2078064) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2078252..2079205) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" /label="yqxL CDS" gene complement(2078252..2079205) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /label="yqxL gene" promotor_-10 complement(2079229..2079248) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2079250) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2079262..2079268) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2079288..2079294 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2079309..2079327 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2079327 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="upshifts" CDS 2079348..2080676 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" /label="yqhB CDS" gene 2079348..2080676 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /label="yqhB gene" S_feature 2080677..2081651 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2080729..2081565) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" /label="rsbRD CDS" gene complement(2080729..2081565) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /label="rsbRD gene" S_feature complement(2081566..2081750) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2081652..2081722 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Gln1 tRNA" gene 2081652..2081722 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /label="trnSL-Gln1 gene" CDS complement(2081789..2082169) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" /label="mgsR CDS" gene complement(2081789..2082169) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /label="mgsR gene" downshifts complement(2081795) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2082198..2082216) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2082217) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2082231..2082237) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2082256..2082261 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2082277..2082295 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2082286 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="upshifts" promotor_-35 2082336..2082343 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2082358 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="upshifts" promotor_-10 2082359..2082378 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2082401..2082646 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" /label="yqgY CDS" gene 2082401..2082646 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /label="yqgY gene" downshifts 2082543 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" /label="downshifts" downshifts 2082632 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" /label="downshifts" S_feature 2082677..2083432 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2082686..2083321) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" /label="yqgX CDS" gene complement(2082686..2083321) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /label="yqgX gene" downshifts complement(2082711) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2083343..2083362) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2083360) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2083376..2083383) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2083400..2083407 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2083422..2083441 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2083434 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2083454) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2083456..2083470) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2083478..2083482) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2083478..2083651 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" /label="yqgW CDS" gene 2083478..2083651 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /label="yqgW gene" downshifts 2083639 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" /label="downshifts" CDS complement(2083683..2083997) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" /label="yqgV CDS" gene complement(2083683..2083997) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /label="yqgV gene" S_feature 2083684..2084751 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2083697) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2084000..2085061) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" /label="yqgU CDS" gene complement(2084000..2085061) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /label="yqgU gene" CDS complement(2085123..2086253) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" /label="yqgT CDS" gene complement(2085123..2086253) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /label="yqgT gene" promotor_-10 complement(2086261..2086279) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2086293) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2086295..2086300) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2086336..2088252) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" /label="ltaSC CDS" gene complement(2086336..2088252) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /label="ltaSC gene" downshifts complement(2086363) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" /label="downshifts" promotor_-35 2087368..2087374 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2087387..2088416 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2087387 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2087390..2087408 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2088253..2088319) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2088313..2088332) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2088319) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2088347..2088354) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2088369..2089334) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" /label="glcK CDS" gene complement(2088369..2089334) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /label="glcK gene" CDS complement(2089345..2089560) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" /label="yqgQ CDS" gene complement(2089345..2089560) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /label="yqgQ gene" S_feature complement(2089561..2089669) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2089670..2091193) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " /label="glpG CDS" gene complement(2089670..2091193) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /label="glpG gene" promotor_-10 complement(2091211..2091230) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2091224) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2091245..2091252) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2091283..2091456) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" /label="yqgO CDS" gene complement(2091283..2091456) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /label="yqgO gene" downshifts complement(2091310) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2091472..2091483) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2091484) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2091497..2091503) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2091523..2092086) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" /label="folN CDS" gene complement(2091523..2092086) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /label="folN gene" S_feature complement(2092087..2092170) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2092171..2092320) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" /label="rpmGA CDS" gene complement(2092171..2092320) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /label="rpmGA gene" downshifts complement(2092217) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2092357..2092376) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2092367) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2092392..2092395) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2092404..2093483) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" /label="yqgM CDS" gene complement(2092404..2093483) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /label="yqgM gene" CDS complement(2093480..2093950) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" /label="yqgL CDS" gene complement(2093480..2093950) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /label="yqgL gene" promotor_-35 2093895..2093903 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2093917..2093925 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2093918..2094091 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2093919 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2093986..2094005) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2093998) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2094017..2094024) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2094063..2094067 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2094083..2094102 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2094093 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" CDS 2094130..2094483 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" /label="yqzD CDS" gene 2094130..2094483 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /label="yqzD gene" CDS 2094480..2094944 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" /label="yqzC CDS" gene 2094480..2094944 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /label="yqzC gene" downshifts 2094930 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2094973..2095755) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" /label="pstBB CDS" gene complement(2094973..2095755) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /label="pstBB gene" downshifts complement(2094984) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2095766..2096575) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" /label="pstBA CDS" gene complement(2095766..2096575) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /label="pstBA gene" CDS complement(2096596..2097480) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" /label="pstA CDS" gene complement(2096596..2097480) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /label="pstA gene" CDS complement(2097480..2098409) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" /label="pstC CDS" gene complement(2097480..2098409) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /label="pstC gene" CDS complement(2098478..2099380) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" /label="pstS CDS" gene complement(2098478..2099380) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /label="pstS gene" upshifts complement(2099435) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2099443..2099459) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2099470..2099472) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" Polymorphism join(2099489,2099491) /Source="geneious" /ID="SNP_BsDelta6_2581727_2581726" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)6 -> (T)7" /Codon_Change /Coverage=117 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=114 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2099535..2101685) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" /label="pbpA CDS" gene complement(2099535..2101685) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /label="pbpA gene" downshifts complement(2099545) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2100279..2100297) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2100287) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2100313..2100319) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2100974..2100993) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2100991) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2101007..2101016) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2101735..2101754) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2101740) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2101770..2101774) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2101799..2103091) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" /label="yqgE CDS" gene complement(2101799..2103091) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /label="yqgE gene" promotor_-10 complement(2103114..2103125) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2103125) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2103139..2103145) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2103198..2103806) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" /label="sodA CDS" gene complement(2103198..2103806) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /label="sodA gene" downshifts complement(2103213) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2103858..2103877) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2103869) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2103871..2103939) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2103892..2103899) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2103930..2103948) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2103939) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2103963..2103969) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2103985..2104467) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" /label="yqgC CDS" gene complement(2103985..2104467) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /label="yqgC gene" S_feature complement(2104468..2104760) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2104510..2104516 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2104531..2104550 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2104544 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="upshifts" CDS 2104577..2105344 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" /label="yqgB CDS" gene 2104577..2105344 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /label="yqgB gene" promotor_-10 complement(2104758..2104776) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2104760) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="upshifts" S_feature complement(2104762..2105698) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2104790..2104796) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2105345..2105775 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2105732 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(2105743) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" CDS complement(2105760..2106188) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" /label="yqgA CDS" gene complement(2105760..2106188) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /label="yqgA gene" promotor_-35 2106184..2106188 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2106198..2106212 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2106207 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="upshifts" promotor_-10 complement(2106211..2106230) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2106234) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="upshifts" promotor_-35 complement(2106245..2106252) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2106403..2106408 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2106424..2106442 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2106436 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2106465..2106764 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" /label="yqfZ CDS" gene 2106465..2106764 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /label="yqfZ gene" promotor_-35 2106777..2106784 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2106799..2106818 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2106810..2106886 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2106810 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2106887..2108020 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" /label="ispG CDS" gene 2106887..2108020 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /label="ispG gene" downshifts 2108001 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(2108046..2108435) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" /label="yqfX CDS" gene complement(2108046..2108435) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /label="yqfX gene" downshifts complement(2108072) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2108466..2108477) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2108470) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2108491..2108497) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2108510..2108517 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2108528..2108547 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2108529 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="upshifts" CDS 2108568..2109149 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" /label="yqfW CDS" gene 2108568..2109149 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /label="yqfW gene" downshifts 2109147 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" /label="downshifts" S_feature 2109192..2109800 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2109192..2109629) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" /label="zur CDS" gene complement(2109192..2109629) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /label="zur gene" downshifts complement(2109196) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2109630..2109724) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2109720..2109739) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2109724) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2109754..2109761) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2109767..2110648) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" /label="yqfU CDS" gene complement(2109767..2110648) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /label="yqfU gene" promotor_-35 2110644..2110649 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2110665..2110683 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2110681 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2110686..2110705) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2110692) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2110694..2111021) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2110710..2110719 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2110726 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2110732..2110751 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2110764..2111018 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" /label="yqfT CDS" gene 2110764..2111018 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /label="yqfT gene" downshifts 2111005 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2111045..2111938) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" /label="nfo CDS" gene complement(2111045..2111938) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /label="nfo gene" S_feature 2111050..2111851 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2111066) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" /label="downshifts" CDS complement(2111948..2113264) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" /label="cshB CDS" gene complement(2111948..2113264) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /label="cshB gene" promotor_-10 complement(2113300..2113319) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2113311) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2113335..2113339) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2113368..2113377 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2113389 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2113391..2113410 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2113433..2114176 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" /label="yqfQ CDS" gene 2113433..2114176 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /label="yqfQ gene" downshifts 2114158 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" promotor_-35 2114180..2114187 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2114201..2114220 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2114203..2114298 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2114203 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="upshifts" CDS 2114299..2115243 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" /label="ispH CDS" gene 2114299..2115243 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /label="ispH gene" downshifts 2115214 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2115266..2116387) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" /label="yqfO CDS" gene complement(2115266..2116387) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /label="yqfO gene" downshifts complement(2115291) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2116380..2117030) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" /label="trmK CDS" gene complement(2116380..2117030) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /label="trmK gene" S_feature complement(2117031..2117139) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2117127..2117146) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2117139) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2117141..2117254) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2117162..2117166) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2117287..2117649) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" /label="cccA CDS" gene complement(2117287..2117649) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /label="cccA gene" downshifts complement(2117299) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-35 2117645..2117649 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2117657..2117671 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2117678 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2117686..2117705) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2117688) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2117690..2117811) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2117717..2117724) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2117800..2117819) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2117808..2117827 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2117811) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2117813..2117952) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2117814..2117918 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2117814 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2117833..2117839) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2117882..2117889 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2117903..2117922 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2117920..2120069 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2117920 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2117978..2119093) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" /label="sigA CDS" gene complement(2117978..2119093) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /label="sigA gene" downshifts complement(2117997) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" /label="downshifts" S_feature complement(2119094..2119291) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2119292..2121103) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" /label="dnaG CDS" gene complement(2119292..2121103) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /label="dnaG gene" promotor_-35 2120698..2120704 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2120714 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2120716..2120735 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2120743..2121039 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" /label="antE CDS" gene 2120743..2121039 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /label="antE gene" CDS complement(2121137..2121631) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" /label="yqxD CDS" gene complement(2121137..2121631) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /label="yqxD gene" promotor_-10 complement(2121604..2121622) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2121615) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2121632..2121745) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2121634..2121642) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2121640..2121645 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2121661..2121679 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2121676 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2121730..2121748) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2121745) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2121747..2121824) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2121764..2121769) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2121790..2121809) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2121824) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2121825..2121828) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2121885..2122697) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" /label="ppsR CDS" gene complement(2121885..2122697) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /label="ppsR gene" CDS complement(2122723..2123361) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" /label="ccpN CDS" gene complement(2122723..2123361) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /label="ccpN gene" S_feature complement(2123362..2123493) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2123487..2123506) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2123494..2125533) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" /label="glyS CDS" gene complement(2123494..2125533) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /label="glyS gene" upshifts complement(2123496) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2123521..2123528) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2123540) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" downshifts complement(2123606) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" /label="downshifts" CDS complement(2125526..2126413) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" /label="glyQ CDS" gene complement(2125526..2126413) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /label="glyQ gene" misc_RNA complement(2126496..2126670) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" /label="tboG RNA" gene complement(2126496..2126670) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /label="tboG gene" downshifts complement(2126530) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" /label="downshifts" promotor_-35 2126645..2126650 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2126666..2126684 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2126674..2126693) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2126676..2128088 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2126676 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2126686) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2126708..2126715) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2126710..2127477) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" /label="recO CDS" gene complement(2126710..2127477) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /label="recO gene" CDS complement(2127514..2127657) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" /label="yqzL CDS" gene complement(2127514..2127657) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /label="yqzL gene" S_feature complement(2127658..2127804) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2127805..2128710) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" /label="era CDS" gene complement(2127805..2128710) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /label="era gene" CDS complement(2128691..2129101) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" /label="cdd CDS" gene complement(2128691..2129101) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /label="cdd gene" promotor_-10 complement(2129139..2129158) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2129150) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2129152..2129219) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2129173..2129176) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2129220..2129591) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" /label="unpK CDS" gene complement(2129220..2129591) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /label="unpK gene" CDS complement(2129572..2130045) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" /label="rnrY CDS" gene complement(2129572..2130045) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /label="rnrY gene" CDS complement(2130046..2132181) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" /label="pgpH CDS" gene complement(2130046..2132181) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /label="pgpH gene" promotor_-35 2132025..2132030 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2132045 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2132046..2132064 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2132260..2133219) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" /label="phoH CDS" gene complement(2132260..2133219) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /label="phoH gene" downshifts complement(2132275) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" CDS complement(2133216..2134412) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" /label="yqfD CDS" gene complement(2133216..2134412) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /label="yqfD gene" promotor_-10 complement(2133283..2133302) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2133288) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2133316..2133323) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2133363..2133381) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2133375) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="upshifts" promotor_-35 complement(2133396..2133402) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2133590) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="upshifts" promotor_-10 complement(2133604..2133615) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2133630..2133636) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2134431..2134712) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" /label="yqfC CDS" gene complement(2134431..2134712) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /label="yqfC gene" CDS complement(2134769..2135188) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" /label="yqfB CDS" gene complement(2134769..2135188) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /label="yqfB gene" downshifts complement(2134783) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2135213..2136208) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" /label="floA CDS" gene complement(2135213..2136208) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /label="floA gene" CDS complement(2136230..2137543) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" /label="nfeDA CDS" gene complement(2136230..2137543) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /label="nfeDA gene" promotor_-10 complement(2137579..2137594) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2137596) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="upshifts" promotor_-35 complement(2137607..2137616) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2137674..2138120) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" /label="yqeY CDS" gene complement(2137674..2138120) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /label="yqeY gene" downshifts complement(2137687) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" downshifts complement(2137885) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(2138135..2138308) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" /label="rpsU CDS" gene complement(2138135..2138308) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /label="rpsU gene" misc_feature 2138244..2138248 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2138249 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2138369..2138388) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2138384) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2138402..2138409) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2138427..2138432 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2138447 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2138448..2138466 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2138481..2139404 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" /label="yqeW CDS" gene 2138481..2139404 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /label="yqeW gene" CDS complement(2139441..2140796) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" /label="mtaB CDS" gene complement(2139441..2140796) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /label="mtaB gene" downshifts complement(2139447) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2140796..2141566) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" /label="rsmE CDS" gene complement(2140796..2141566) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /label="rsmE gene" CDS complement(2141589..2142524) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" /label="prmA CDS" gene complement(2141589..2142524) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /label="prmA gene" CDS complement(2142549..2143676) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" /label="dnaJ CDS" gene complement(2142549..2143676) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /label="dnaJ gene" misc_feature 2143593..2143596 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2143604 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2143677..2143854) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2143716..2143806 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surC RNA" gene 2143716..2143806 /gene="surC" /locus_tag="BSU_misc_RNA_79" /label="surC gene" CDS complement(2143876..2145711) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" /label="dnaK CDS" gene complement(2143876..2145711) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /label="dnaK gene" downshifts complement(2143899) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" /label="downshifts" CDS complement(2145735..2146298) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" /label="grpE CDS" gene complement(2145735..2146298) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /label="grpE gene" S_feature complement(2146299..2146369) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2146370..2147401) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" /label="hrcA CDS" gene complement(2146370..2147401) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /label="hrcA gene" promotor_-10 complement(2147442..2147461) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2147455) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2147476..2147483) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2147482..2148621) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" /label="hemN CDS" gene complement(2147482..2148621) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /label="hemN gene" promotor_-10 complement(2148494..2148505) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2148498) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="upshifts" promotor_-35 complement(2148519..2148525) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2148674..2150512) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" /label="lepA CDS" gene complement(2148674..2150512) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /label="lepA gene" downshifts complement(2148696) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2150547..2150566) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2150564) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2150582..2150586) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2150646..2150984) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" /label="yqxA CDS" gene complement(2150646..2150984) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /label="yqxA gene" downshifts complement(2150652) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2151001..2152206) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" /label="spoIIP CDS" gene complement(2151001..2152206) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /label="spoIIP gene" promotor_-10 complement(2152226..2152244) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2152238) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2152260..2152265) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2152269..2153375) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" /label="gpr CDS" gene complement(2152269..2153375) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /label="gpr gene" promotor_-10 complement(2153403..2153414) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2153410) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2153429..2153435) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2153474..2153477 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2153490 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2153493..2153512 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2153504..2153578 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2153579..2153845 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" /label="rpsT CDS" gene 2153579..2153845 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /label="rpsT gene" downshifts 2153834 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2153860..2154903) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" /label="holA CDS" gene complement(2153860..2154903) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /label="holA gene" downshifts complement(2153905) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2154932..2154951) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2154943..2155092) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" /label="hypothetical protein CDS" gene complement(2154943..2155092) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /label="gene" upshifts complement(2154944) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2154965..2154969) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2154967..2155306) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2155010) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" /label="downshifts" promotor_-35 2155079..2155085 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2155099..2155118 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2155100 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="upshifts" CDS 2155133..2155267 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" /label="yqzM CDS" gene 2155133..2155267 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /label="yqzM gene" downshifts 2155261 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" /label="downshifts" CDS complement(2155307..2157637) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" /label="comEC CDS" gene complement(2155307..2157637) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /label="comEC gene" promotor_-10 complement(2155324..2155343) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2155340) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2155357..2155366) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2157641..2158210) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" /label="comEB CDS" gene complement(2157641..2158210) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /label="comEB gene" promotor_-10 complement(2158237..2158256) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2158247) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2158271..2158278) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2158277..2158894) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" /label="comEA CDS" gene complement(2158277..2158894) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /label="comEA gene" promotor_-35 2158915..2158920 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2158932 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2158936..2158954 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2158955..2158969) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2158957) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2158959..2159806) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2158978..2158982) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2158978..2159799 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" /label="comER CDS" gene 2158978..2159799 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /label="comER gene" promotor_-10 complement(2159794..2159813) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2159800..2159880 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2159807) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2159827..2159834) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2159840 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2159865..2160608) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" /label="yqeM CDS" gene complement(2159865..2160608) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /label="yqeM gene" downshifts complement(2159895) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2160605..2160961) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" /label="rsfS CDS" gene complement(2160605..2160961) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /label="rsfS gene" CDS complement(2160979..2161539) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" /label="yqeK CDS" gene complement(2160979..2161539) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /label="yqeK gene" CDS complement(2161529..2162098) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" /label="nadD CDS" gene complement(2161529..2162098) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /label="nadD gene" CDS complement(2162110..2162400) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" /label="yqeI CDS" gene complement(2162110..2162400) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /label="yqeI gene" CDS complement(2162394..2163236) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" /label="aroE CDS" gene complement(2162394..2163236) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /label="aroE gene" downshifts 2163228 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" /label="downshifts" CDS complement(2163254..2164354) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" /label="rgpH CDS" gene complement(2163254..2164354) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /label="rgpH gene" CDS complement(2164358..2164876) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" /label="yqeG CDS" gene complement(2164358..2164876) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /label="yqeG gene" promotor_-10 complement(2164786..2164803) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2164800) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2164819..2164822) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2164877..2165438) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2164910) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" /label="downshifts" promotor_-35 2165101..2165108 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2165119..2165219 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2165119..2165138 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2165119 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(2165169..2165427) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sdaM RNA" gene complement(2165169..2165427) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /label="sdaM gene" CDS 2165220..2165378 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" /label="sda CDS" gene 2165220..2165378 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /label="sda gene" S_feature 2165379..2165625 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2165426..2165445) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2165437) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2165461..2165465) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2165489..2165636) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2165526) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2165582 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 2165627..>2165704 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2165631..2165650) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2165636) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2165663..2165672) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2165704,2165706) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" N_region 2165705 /note="inserted C residue" /created_by="User" /modified_by="User" /label="IIG_Bs27_003" S_feature <2165706..2166148 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" CDS complement(2165719..2166135) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" /label="psiE CDS" gene complement(2165719..2166135) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /label="psiE gene" CDS complement(2166181..2167479) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" /label="yrkQ CDS" gene complement(2166181..2167479) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /label="yrkQ gene" CDS complement(2167466..2168161) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" /label="yrkP CDS" gene complement(2167466..2168161) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /label="yrkP gene" misc_feature complement(2168227..2168244) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2168236) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2168322..2168328 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2168335..2168353 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2168350 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2168429..2169646 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" /label="yrkO CDS" gene 2168429..2169646 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /label="yrkO gene" promotor_-35 2168888..2168895 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2168910..2168929 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2168926 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2169565..2169813 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" /label="hypothetical protein CDS" gene 2169565..2169813 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /label="gene" S_feature complement(2169742..2170789) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2170158..2170715 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" /label="yrkN CDS" gene 2170158..2170715 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /label="yrkN gene" S_feature 2170716..2170838 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2170791..2171205) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2170834) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" CDS complement(2171206..2171730) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" /label="yrkL CDS" gene complement(2171206..2171730) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /label="yrkL gene" promotor_-35 2171578..2171585 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2171596..2171615 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2171610 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2171731..2171818) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2171813..2171832) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2171818) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2171820..>2171956) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2171847..2171854) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(2171956,2171963) /created_by="User" /note="deletion occured in betwen marked nucleotides " /modified_by="User" /label="IIG_Bs12" N_region 2171957..2171962 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs12" CDS complement(2172015..2172545) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" /label="sigZ CDS" gene complement(2172015..2172545) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /label="sigZ gene" promotor_-10 complement(2172591..2172610) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2172614) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2172624..2172631) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2172680..2173660 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" /label="yrpG CDS" gene 2172680..2173660 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /label="yrpG gene" CDS complement(2173934..2175250) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" /label="yraO CDS" gene complement(2173934..2175250) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /label="yraO gene" S_feature complement(2175251..2175364) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2175365..2176234) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" /label="yraN CDS" gene complement(2175365..2176234) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /label="yraN gene" promotor_-10 complement(2176257..2176276) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2176274) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2176291..2176296) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2176341..2176342) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2176349) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2176379..2176380) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2176379..2177482 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" /label="prpF CDS" gene 2176379..2177482 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /label="prpF gene" misc_feature 2177372..2177391 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2177378 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2177729) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" /label="downshifts" CDS complement(2177755..2178588) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" /label="csn CDS" gene complement(2177755..2178588) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /label="csn gene" misc_feature complement(2178618..2178637) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2178627) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2178793..2178797 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2178808..2179030 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2178808 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2178812..2178831 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2179031..2179294 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" /label="yraL CDS" gene 2179031..2179294 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /label="yraL gene" downshifts 2179282 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS 2179431..2180246 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" /label="yraK CDS" gene 2179431..2180246 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /label="yraK gene" S_feature complement(2180581..2180653) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2180624) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2180654..2181010) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" /label="yraJ CDS" gene complement(2180654..2181010) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /label="yraJ gene" CDS complement(2181063..2181422) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" /label="yraI CDS" gene complement(2181063..2181422) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /label="yraI gene" misc_feature complement(2181515..2181534) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2181525) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2181694..2181795) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" /label="hypothetical protein CDS" gene complement(2181694..2181795) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /label="gene" S_feature complement(2181835..2181937) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2181877) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2181938..2182324) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" /label="yraH CDS" gene complement(2181938..2182324) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /label="yraH gene" misc_feature complement(2182366..2182382) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2182382) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2182515..2182521 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2182536..2182547 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2182536 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="upshifts" CDS 2182573..2182818 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" /label="yraG CDS" gene 2182573..2182818 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /label="yraG gene" CDS 2182836..2183204 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" /label="yraF CDS" gene 2182836..2183204 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /label="yraF gene" CDS 2183223..2184359 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" /label="adhB CDS" gene 2183223..2184359 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /label="adhB gene" CDS 2184378..2184575 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" /label="yraE CDS" gene 2184378..2184575 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /label="yraE gene" CDS 2184591..2184890 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" /label="yraD CDS" gene 2184591..2184890 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /label="yraD gene" downshifts 2184881 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2185153..2185575) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" /label="adhR CDS" gene complement(2185153..2185575) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /label="adhR gene" promotor_-35 2185573..2185576 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2185592..2185611 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2185607..2185757 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2185607 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="upshifts" promotor_-10 complement(2185610..2185629) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2185617) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2185643..2185650) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2185726..2185745) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2185734) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="upshifts" CDS 2185758..2185952 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" /label="yrzP CDS" gene 2185758..2185952 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /label="yrzP gene" promotor_-35 complement(2185760..2185767) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2185970..2185977 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2185993..2186012 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2185997 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="upshifts" S_feature 2185998..2186082 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2186083..2187132 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" /label="adhA CDS" gene 2186083..2187132 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /label="adhA gene" promotor_-35 2187200..2187207 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2187222..2187241 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2187235 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="upshifts" CDS 2187263..2187772 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" /label="sufL CDS" gene 2187263..2187772 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /label="sufL gene" downshifts 2187741 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" /label="downshifts" S_feature 2187786..2188891 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2187814..2189847) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" /label="sacC CDS" gene complement(2187814..2189847) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /label="sacC gene" downshifts complement(2187839) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2189756..2189923) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" /label="hypothetical protein CDS" gene complement(2189756..2189923) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /label="gene" S_feature complement(2189848..2190003) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2190004..2190831) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " /label="levG CDS" gene complement(2190004..2190831) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /label="levG gene" CDS complement(2190852..2191661) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" /label="levF CDS" gene complement(2190852..2191661) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /label="levF gene" CDS complement(2191678..2192166) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" /label="levE CDS" gene complement(2191678..2192166) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /label="levE gene" CDS complement(2192166..2192606) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" /label="levD CDS" gene complement(2192166..2192606) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /label="levD gene" downshifts 2192603 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" /label="downshifts" misc_feature complement(2192643..2192661) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2192647) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2192796..2195603) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" /label="levR CDS" gene complement(2192796..2195603) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /label="levR gene" misc_feature complement(2195819..2195838) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2195825) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="upshifts" CDS 2196150..2196290 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" /label="hypothetical protein CDS" gene 2196150..2196290 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /label="gene" misc_feature 2196271..2196290 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2196281 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="upshifts" CDS 2196329..2197717 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" /label="aapA CDS" gene 2196329..2197717 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /label="aapA gene" downshifts 2197706 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(2197739..2197812) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2197781) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2197813..2198445) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" /label="yrhP CDS" gene complement(2197813..2198445) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /label="yrhP gene" downshifts complement(2197869) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2198499..2198518) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2198510) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2198524..2198530 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2198533..2198540) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2198544..2198563 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2198549 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="upshifts" CDS 2198598..2199425 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " /label="yrhO CDS" gene 2198598..2199425 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /label="yrhO gene" downshifts 2199421 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2199538..2199547 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2199560..2199575 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2199565 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="upshifts" CDS 2199621..2200121 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" /label="sigV CDS" gene 2199621..2200121 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /label="sigV gene" CDS 2200121..2200978 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" /label="rsiV CDS" gene 2200121..2200978 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /label="rsiV gene" promotor_-10 complement(2200996..2201007) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2201015) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2201022..2201028) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2201089..2202993 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" /label="oatA CDS" gene 2201089..2202993 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /label="oatA gene" promotor_-35 2203074..2203080 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2203096..2203114 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2203102 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="upshifts" CDS 2203127..2203417 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" /label="yrhK CDS" gene 2203127..2203417 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /label="yrhK gene" S_feature 2203418..2203533 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2203515..2203522 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2203535..2203660 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2203535 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2203536..2203554 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2203554..2203654 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" /label="surF RNA" gene 2203554..2203654 /gene="surF" /locus_tag="BSU_misc_RNA_82" /label="surF gene" downshifts 2203617 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2203661..2206825) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" /label="cypB CDS" gene complement(2203661..2206825) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /label="cypB gene" downshifts complement(2203677) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2204811..2204820 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2204834..2204853 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2204855 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2206841..2207425) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" /label="bscR CDS" gene complement(2206841..2207425) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /label="bscR gene" CDS complement(2207648..2208190) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" /label="yrhH CDS" gene complement(2207648..2208190) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /label="yrhH gene" S_feature complement(2208191..2208276) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2208274..2208289) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2208276) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2208302..2208311) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2208345..2208561) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2208379..2208537) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" /label="hypothetical protein CDS" gene complement(2208379..2208537) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /label="gene" downshifts complement(2208388) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2208559..2208578) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2208561) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2208563..2208693) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2208592..2208601) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2208694..2208843) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" /label="yrzI CDS" gene complement(2208694..2208843) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /label="yrzI gene" downshifts 2208837 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" /label="downshifts" S_feature complement(2208844..2208934) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2208936..2209155) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2208979) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" downshifts 2209101 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2209134..2209153) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2209155) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2209157..2209232) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2209168..2209175) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2209233..2210033) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" /label="yrhG CDS" gene complement(2209233..2210033) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /label="yrhG gene" S_feature complement(2210102..2210255) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2210145) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2210246..2210265) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2210255) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="upshifts" promotor_-35 complement(2210280..2210286) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2210296..2210664) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" /label="yrhF CDS" gene complement(2210296..2210664) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /label="yrhF gene" S_feature complement(2210665..2210761) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2210747..2210766) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2210751..2210754 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2210767) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="upshifts" promotor_-10 2210770..2210789 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2210772 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="upshifts" S_feature 2210773..2210979 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2210782..2210786) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2210980..2213922 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" /label="yrhE CDS" gene 2210980..2213922 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /label="yrhE gene" CDS 2213941..2214423 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" /label="yrhD CDS" gene 2213941..2214423 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /label="yrhD gene" downshifts 2214403 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2214459..2214689) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" /label="yrhC CDS" gene complement(2214459..2214689) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /label="yrhC gene" downshifts complement(2214479) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2214690..2214771) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2214772..2215911) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" /label="mccB CDS" gene complement(2214772..2215911) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /label="mccB gene" CDS complement(2215913..2216836) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" /label="mccA CDS" gene complement(2215913..2216836) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /label="mccA gene" downshifts complement(2216829) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" /label="downshifts" S_feature complement(2216837..2216900) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2216901..2217596) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" /label="mtnN CDS" gene complement(2216901..2217596) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /label="mtnN gene" promotor_-10 complement(2217336..2217355) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2217354) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2217368..2217377) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2217617..2218258) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" /label="yrrT CDS" gene complement(2217617..2218258) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /label="yrrT gene" promotor_-10 complement(2217825..2217844) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2217844) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2217861..2217864) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2218310..2218319 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2218316..2218335) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2218322) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2218332..2218351 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2218341..2218405 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2218341 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2218351..2218354) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2218386..2218393 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2218407 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2218409..2218426 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2218451..2218654 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" /label="yrzA CDS" gene 2218451..2218654 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /label="yrzA gene" downshifts 2218661 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2218691..2219392) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" /label="yrrS CDS" gene complement(2218691..2219392) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /label="yrrS gene" downshifts complement(2218703) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2219457..2221211) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" /label="pbpI CDS" gene complement(2219457..2221211) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /label="pbpI gene" misc_feature complement(2219485..2219504) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2219495) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2220526..2220541) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2220529) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2220554..2220563) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2220757..2220775) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2220771) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2220790..2220797 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2220790..2220795) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2220812..2220831 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2220817 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2221265..2221738) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" /label="greA CDS" gene complement(2221265..2221738) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /label="greA gene" downshifts complement(2221272) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(2221739..2221871) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2221853..2221872) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2221871) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2221873..2221981) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2221886..2221893) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2221974..2221993) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2221981) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2221989..2222624) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" /label="udk CDS" gene complement(2221989..2222624) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /label="udk gene" promotor_-35 complement(2222009..2222013) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2222119..2222124 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2222140..2222158 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2222147 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2222631..2223899) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" /label="yrrO CDS" gene complement(2222631..2223899) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /label="yrrO gene" CDS complement(2223918..2224847) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" /label="yrrN CDS" gene complement(2223918..2224847) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /label="yrrN gene" CDS complement(2224853..2225506) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " /label="yrrM CDS" gene complement(2224853..2225506) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /label="yrrM gene" S_feature complement(2225507..2225611) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2225593..2225612) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2225611) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2225628..2225632) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2225658..2226740) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" /label="yrrL CDS" gene complement(2225658..2226740) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /label="yrrL gene" downshifts complement(2225692) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2226756..2226775) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2226776) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2226790..2226793) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2226866) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2226871..2227152) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" /label="yrzB CDS" gene complement(2226871..2227152) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /label="yrzB gene" downshifts complement(2226931) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2227170..2227586) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" /label="rimF CDS" gene complement(2227170..2227586) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /label="rimF gene" promotor_-10 complement(2227418..2227436) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2227437) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2227452..2227457) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2227594..2227860) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" /label="yrzL CDS" gene complement(2227594..2227860) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /label="yrzL gene" promotor_-35 2227748..2227756 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2227771..2227790 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2227779..2228968 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2227779 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2227861..2227921) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2227915..2227934) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2227921) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2227945..2230581) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" /label="alaS CDS" gene complement(2227945..2230581) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /label="alaS gene" promotor_-35 complement(2227948..2227955) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2230347..2230365) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2230363) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2230379..2230386) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2230582..2230660) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2230661..2230868) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboA RNA" gene complement(2230661..2230868) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /label="tboA gene" promotor_-10 complement(2230876..2230895) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2230891) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2230910..2230917) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2230912..2231973) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" /label="yrrI CDS" gene complement(2230912..2231973) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /label="yrrI gene" promotor_-35 2231882..2231887 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2231893..2232128 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2231894 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2231903..2231921 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2231990..2232001) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2231991) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2232015..2232021) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2232129..2232857 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" /label="glnQ CDS" gene 2232129..2232857 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /label="glnQ gene" downshifts complement(2232585) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" CDS 2232879..2233700 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" /label="glnH CDS" gene 2232879..2233700 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /label="glnH gene" CDS 2233761..2234411 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" /label="glnM CDS" gene 2233761..2234411 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /label="glnM gene" CDS 2234428..2235084 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" /label="glnP CDS" gene 2234428..2235084 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /label="glnP gene" downshifts 2235083 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2235119..2235250) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " /label="yrzQ CDS" gene complement(2235119..2235250) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /label="yrzQ gene" downshifts complement(2235137) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2235272..2235463) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" /label="yrzR CDS" gene complement(2235272..2235463) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /label="yrzR gene" CDS complement(2235475..2235999) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" /label="yrrD CDS" gene complement(2235475..2235999) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /label="yrrD gene" upshifts complement(2235586) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2235590..2235601) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2235616..2235622) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2235970..2235981) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2235976) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2235996..2236002) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2236057..2238453) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" /label="recDB CDS" gene complement(2236057..2238453) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /label="recDB gene" downshifts complement(2236083) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2236303..2236309 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2236317 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2236324..2236335 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2236337..2236686 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2236438) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" /label="downshifts" CDS complement(2238478..2239098) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" /label="yrrB CDS" gene complement(2238478..2239098) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /label="yrrB gene" CDS complement(2239184..2240299) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" /label="mnmA CDS" gene complement(2239184..2240299) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /label="mnmA gene" downshifts complement(2239185) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" CDS complement(2240330..2241469) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" /label="iscSA CDS" gene complement(2240330..2241469) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /label="iscSA gene" promotor_-10 complement(2241036..2241055) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2241048) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2241069..2241076) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2241488..2241904) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" /label="cymR CDS" gene complement(2241488..2241904) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /label="cymR gene" S_feature complement(2241905..2242002) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2241987..2242006) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2242002) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2242022..2242025) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2242050..2242057 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2242071..2242090 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2242079 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="upshifts" CDS 2242107..2243372 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" /label="rarA CDS" gene 2242107..2243372 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /label="rarA gene" downshifts 2243371 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2243414..2244178) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" /label="tcdA CDS" gene complement(2243414..2244178) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /label="tcdA gene" downshifts complement(2243432) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2244262..2244462) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" /label="ssrSB RNA" gene complement(2244262..2244462) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /label="ssrSB gene" downshifts complement(2244280) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" /label="downshifts" upshifts 2244449 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2244450..2244459 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2244460..2244479) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2244471) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2244492..2244499) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2244514..2246292) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" /label="aspS CDS" gene complement(2244514..2246292) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /label="aspS gene" CDS complement(2246306..2247580) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" /label="hisS CDS" gene complement(2246306..2247580) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /label="hisS gene" misc_RNA complement(2247670..2247902) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" /label="tboH RNA" gene complement(2247670..2247902) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /label="tboH gene" downshifts complement(2247700) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2247912..2247915 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2247926..2247945) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2247930..2247949 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2247932..2248216 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2247932 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2247945) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2247960..2247967) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2247962..2248132) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" /label="yrzK CDS" gene complement(2247962..2248132) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /label="yrzK gene" promotor_-10 complement(2248163..2248174) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2248180) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="upshifts" promotor_-35 complement(2248189..2248195) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2248192..2248199 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2248213..2248231 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2248218 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2248265..2249821 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" /label="yrvJ CDS" gene 2248265..2249821 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /label="yrvJ gene" downshifts 2249800 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2249848..2250246) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" /label="dtd CDS" gene complement(2249848..2250246) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /label="dtd gene" downshifts complement(2249856) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2250300..2252504) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" /label="rsh CDS" gene complement(2250300..2252504) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /label="rsh gene" promotor_-10 complement(2252533..2252552) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2252540) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2252542..2252632) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2252567..2252574) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2252596 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" /label="downshifts" CDS complement(2252672..2253184) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" /label="apt CDS" gene complement(2252672..2253184) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /label="apt gene" downshifts complement(2252677) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" CDS complement(2253190..2255550) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" /label="recJ CDS" gene complement(2253190..2255550) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /label="recJ gene" promotor_-10 complement(2253654..2253673) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2253662) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2253687..2253696) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2255564..2255583) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2255575) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2255598..2255604) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2255617..2255940) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" /label="yrvD CDS" gene complement(2255617..2255940) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /label="yrvD gene" promotor_-10 complement(2255961..2255979) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2255972) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2255994..2256000) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2256016..2256513) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" /label="yrvC CDS" gene complement(2256016..2256513) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /label="yrvC gene" S_feature complement(2256514..2256589) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2256583..2256602) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2256589) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="upshifts" promotor_-35 complement(2256616..2256623) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2256671..2258884) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" /label="secDF CDS" gene complement(2256671..2258884) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /label="secDF gene" downshifts complement(2256676) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" promotor_-35 2258443..2258448 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2258462..2258481 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2258470 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2258923..2259219) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" /label="comN CDS" gene complement(2258923..2259219) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /label="comN gene" downshifts 2259130 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" /label="downshifts" S_feature complement(2259220..2259298) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2259260..2259265 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2259282..2259300 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2259284..2259303) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2259284 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="upshifts" upshifts complement(2259298) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="upshifts" S_feature complement(2259300..2260218) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2259318..2259321) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2259335..2260891 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" /label="spoVB CDS" gene 2259335..2260891 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /label="spoVB gene" promotor_-10 complement(2260204..2260222) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2260218) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="upshifts" promotor_-35 complement(2260234..2260242) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2260892..2261656 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2260895..2261551) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" /label="yrbG CDS" gene complement(2260895..2261551) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /label="yrbG gene" promotor_-10 complement(2261570..2261581) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2261582) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2261595..2261601) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2261634..2261639 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2261655..2261673 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2261658 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2261686..2262138 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" /label="yrzE CDS" gene 2261686..2262138 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /label="yrzE gene" downshifts 2262122 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2262177) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2262195..2262461) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" /label="yrbF CDS" gene complement(2262195..2262461) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /label="yrbF gene" CDS complement(2262498..2263643) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" /label="tgt CDS" gene complement(2262498..2263643) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /label="tgt gene" upshifts complement(2262550) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2262594) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2262596..2262615) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2262630..2262635) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2263670..2264698) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" /label="queA CDS" gene complement(2263670..2264698) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /label="queA gene" CDS complement(2264728..2264928) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" /label="yrzS CDS" gene complement(2264728..2264928) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /label="yrzS gene" CDS complement(2264921..2265925) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" /label="ruvB CDS" gene complement(2264921..2265925) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /label="ruvB gene" CDS complement(2265936..2266541) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" /label="ruvA CDS" gene complement(2265936..2266541) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /label="ruvA gene" promotor_-10 complement(2266560..2266579) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2266576) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2266578..2266679) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2266590..2266596) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2266680..2267192) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" /label="bofC CDS" gene complement(2266680..2267192) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /label="bofC gene" promotor_-10 complement(2267221..2267232) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2267236) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="upshifts" CDS complement(2267240..2268547) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" /label="csbX CDS" gene complement(2267240..2268547) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /label="csbX gene" promotor_-35 complement(2267247..2267253) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2268501) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2268571..2268589) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2268586) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="upshifts" promotor_-35 complement(2268604..2268610) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2268618..2269643) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" /label="yrbE CDS" gene complement(2268618..2269643) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /label="yrbE gene" promotor_-10 complement(2269680..2269699) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2269700) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="upshifts" promotor_-35 complement(2269714..2269721) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2269769..2269776 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2269790..2269809 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2269798 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2269830..2269835 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2269844 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2269851..2269869 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2269881..2270528 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" /label="yrzF CDS" gene 2269881..2270528 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /label="yrzF gene" S_feature complement(2270203..2270536) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2270507 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(2270538..2270735) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2270574..2270696) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" /label="hypothetical protein CDS" gene complement(2270574..2270696) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /label="gene" downshifts complement(2270581) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2270744) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2270745..2270762) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2270769..2270776) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2270781..2271071 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" /label="yrzH CDS" gene 2270781..2271071 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /label="yrzH gene" misc_feature 2270792..2270811 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2270792..2270939 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2270792 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="upshifts" CDS 2271078..2271218 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" /label="yrzT CDS" gene 2271078..2271218 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /label="yrzT gene" downshifts 2271207 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2271267..2271273 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2271281..2271381 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2271288..2271306 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2271289 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="upshifts" upshifts 2271341 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="upshifts" CDS 2271382..2272836 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" /label="alaP CDS" gene 2271382..2272836 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /label="alaP gene" downshifts 2272837 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2272877..2273599) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" /label="yrbC CDS" gene complement(2272877..2273599) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /label="yrbC gene" S_feature 2272882..2273303 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2272893) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2273622..2273641) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2273639) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2273655..2273662) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2273702..2274298) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" /label="sgpA CDS" gene complement(2273702..2274298) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /label="sgpA gene" downshifts complement(2273717) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2274341..2274352) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2274343) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2274345..2274409) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2274367..2274373) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2274446..2275609) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" /label="safA CDS" gene complement(2274446..2275609) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /label="safA gene" downshifts complement(2274454) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" /label="downshifts" S_feature complement(2275610..2275685) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2275661..2275679) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2275685) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2275695..2275700) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2275726..2276832) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" /label="nadA CDS" gene complement(2275726..2276832) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /label="nadA gene" promotor_-10 complement(2276408..2276426) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2276433) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2276442..2276447) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2276744 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2276745..2276748 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2276819..2277688) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" /label="nadC CDS" gene complement(2276819..2277688) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /label="nadC gene" downshifts 2276913 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2277642..2279237) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" /label="nadB CDS" gene complement(2277642..2279237) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /label="nadB gene" promotor_-35 2279265..2279272 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2279265..2279284) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2279286 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2279288..2279307 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2279289) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2279299..2279306) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2279340..2280527 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" /label="nifS CDS" gene 2279340..2280527 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /label="nifS gene" promotor_-10 complement(2279341..2279360) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2279359) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2279375..2279384) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2280242..2280247 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2280256 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2280258..2280277 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2280487..2281029 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" /label="niaR CDS" gene 2280487..2281029 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /label="niaR gene" downshifts 2281012 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2281054..2281911) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" /label="pheA CDS" gene complement(2281054..2281911) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /label="pheA gene" S_feature 2281057..2281766 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2281074) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2281928..2282371) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" /label="thrR CDS" gene complement(2281928..2282371) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /label="thrR gene" CDS complement(2282432..2283718) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" /label="obgE CDS" gene complement(2282432..2283718) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /label="obgE gene" CDS complement(2283752..2284330) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" /label="spo0B CDS" gene complement(2283752..2284330) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /label="spo0B gene" S_feature complement(2284331..2284396) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2284381..2284400) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2284396) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2284398..2284615) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2284408..2284530 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" /label="hypothetical protein CDS" gene 2284408..2284530 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /label="gene" promotor_-35 complement(2284414..2284421) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2284651..2284935) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" /label="rpmA CDS" gene complement(2284651..2284935) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /label="rpmA gene" downshifts complement(2284660) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" CDS complement(2284948..2285286) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" /label="rppA CDS" gene complement(2284948..2285286) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /label="rppA gene" CDS complement(2285289..2285597) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" /label="rplU CDS" gene complement(2285289..2285597) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /label="rplU gene" misc_RNA complement(2285611..2285686) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" /label="ldlU RNA" gene complement(2285611..2285686) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /label="ldlU gene" promotor_-10 complement(2285698..2285717) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2285718) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2285731..2285738) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2285744..2286610) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" /label="spoIVFB CDS" gene complement(2285744..2286610) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /label="spoIVFB gene" CDS complement(2286603..2287397) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" /label="spoIVFA CDS" gene complement(2286603..2287397) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /label="spoIVFA gene" downshifts 2287400 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" /label="downshifts" promotor_no_box 2287406..2287506 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2287421..2287439) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2287432) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="upshifts" promotor_-35 complement(2287455..2287460) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2287466 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2287509 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(2287544) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2287547..2288353) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" /label="minD CDS" gene complement(2287547..2288353) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /label="minD gene" CDS complement(2288355..2289035) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" /label="minC CDS" gene complement(2288355..2289035) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /label="minC gene" CDS complement(2289088..2289606) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" /label="mreD CDS" gene complement(2289088..2289606) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /label="mreD gene" CDS complement(2289603..2290475) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" /label="mreC CDS" gene complement(2289603..2290475) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /label="mreC gene" CDS complement(2290506..2291519) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" /label="mreB CDS" gene complement(2290506..2291519) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /label="mreB gene" upshifts complement(2291560) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2291572..2291590) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2291611..2292306) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" /label="ysxA CDS" gene complement(2291611..2292306) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /label="ysxA gene" CDS complement(2292343..2292912) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" /label="maf CDS" gene complement(2292343..2292912) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /label="maf gene" promotor_-10 complement(2292764..2292779) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2292773) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2292792..2292801) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2292951..2292970) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2292967) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2292984..2292990) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2293063) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2293065..2294063) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" /label="spoIIB CDS" gene complement(2293065..2294063) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /label="spoIIB gene" promotor_-10 complement(2294110..2294129) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2294118) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2294141..2294148) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2294186) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS complement(2294197..2294943) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" /label="comC CDS" gene complement(2294197..2294943) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /label="comC gene" promotor_-10 complement(2294971..2294990) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2294978) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2295005..2295012) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2295083..2296375) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" /label="folC CDS" gene complement(2295083..2296375) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /label="folC gene" downshifts complement(2295088) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2296376..2296434) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2296435..2299077) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" /label="valS CDS" gene complement(2296435..2299077) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /label="valS gene" S_feature complement(2299078..2299136) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2299137..2299359) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboV RNA" gene complement(2299137..2299359) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /label="tboV gene" downshifts complement(2299180) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2299388..2299407) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2299400) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2299402..2299510) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2299422..2299427) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2299464..2299473 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2299486..2299505 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2299487 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2299503..2299517) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2299510) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2299525..2299529) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2299525..2299716 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" /label="yszA CDS" gene 2299525..2299716 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /label="yszA gene" CDS complement(2299735..2300760) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" /label="cotN CDS" gene complement(2299735..2300760) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /label="cotN gene" downshifts complement(2299765) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" /label="downshifts" CDS complement(2300793..2302520) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" /label="spoVID CDS" gene complement(2300793..2302520) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /label="spoVID gene" promotor_-35 2302122..2302125 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2302141..2302160 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2302147 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2302516..2302520 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2302529..2302543 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2302543 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2302558..2302576) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2302574) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="upshifts" promotor_-35 complement(2302592..2302597) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2302651..2303943) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" /label="hemL CDS" gene complement(2302651..2303943) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /label="hemL gene" downshifts complement(2302668) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2303973..2304947) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" /label="hemB CDS" gene complement(2303973..2304947) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /label="hemB gene" CDS complement(2304944..2305732) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" /label="hemD CDS" gene complement(2304944..2305732) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /label="hemD gene" CDS complement(2305722..2306666) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" /label="hemC CDS" gene complement(2305722..2306666) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /label="hemC gene" CDS complement(2306699..2307529) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" /label="hemX CDS" gene complement(2306699..2307529) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /label="hemX gene" CDS complement(2307537..2308904) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" /label="hemA CDS" gene complement(2307537..2308904) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /label="hemA gene" misc_feature complement(2308968..2308987) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2308974) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2308976..2309065) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2309025..2309044 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2309033 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2309062..2309081) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2309065) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2309067..2309483) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2309092..2309100) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2309134..2309631 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" /label="ysxD CDS" gene 2309134..2309631 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /label="ysxD gene" promotor_-10 complement(2309467..2309485) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2309483) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2309485..2309615) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2309501..2309507) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2309595..2309606) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2309615) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="upshifts" promotor_-35 complement(2309621..2309627) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2309653..2310240) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" /label="engB CDS" gene complement(2309653..2310240) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /label="engB gene" downshifts complement(2309681) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2310237..2312561) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" /label="lonA CDS" gene complement(2310237..2312561) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /label="lonA gene" S_feature complement(2312562..2312673) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2312658..2312677) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2312673) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2312691..2312698) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2312742..2314400) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" /label="lonB CDS" gene complement(2312742..2314400) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /label="lonB gene" downshifts complement(2312761) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2314444..2314462) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2314455) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2314478..2314483) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2314552..2315814) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" /label="clpX CDS" gene complement(2314552..2315814) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /label="clpX gene" downshifts complement(2314562) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2315815..2315904) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2315892..2315911) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2315904) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2315906..2316037) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2315923..2315930) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2316082) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" CDS complement(2316086..2317360) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" /label="tig CDS" gene complement(2316086..2317360) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /label="tig gene" S_feature complement(2317361..2317550) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2317537..2317556) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2317550) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2317571..2317575) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2317588..2318592) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" /label="ysoA CDS" gene complement(2317588..2318592) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /label="ysoA gene" promotor_-10 complement(2318617..2318636) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2318635) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2318648..2318655) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2318711..2319310) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" /label="leuD CDS" gene complement(2318711..2319310) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /label="leuD gene" downshifts complement(2318732) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" /label="downshifts" CDS complement(2319323..2320741) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" /label="leuC CDS" gene complement(2319323..2320741) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /label="leuC gene" promotor_-35 2320630..2320634 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2320649..2320653 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2320649 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2320791..2321888) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" /label="leuB CDS" gene complement(2320791..2321888) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /label="leuB gene" CDS complement(2321909..2323465) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" /label="leuA CDS" gene complement(2321909..2323465) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /label="leuA gene" promotor_-35 2322305..2322308 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2322321..2324762 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2322321 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2322323..2322342 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2323452..2324480) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" /label="ilvC CDS" gene complement(2323452..2324480) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /label="ilvC gene" CDS complement(2324504..2325022) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" /label="ilvH CDS" gene complement(2324504..2325022) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /label="ilvH gene" promotor_-35 2324743..2324746 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2324762..2324766 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2324764 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2325019..2326743) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" /label="ilvB CDS" gene complement(2325019..2326743) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /label="ilvB gene" S_feature complement(2326744..2326864) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2326865..2327111) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboILV RNA" gene complement(2326865..2327111) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /label="tboILV gene" downshifts complement(2326908) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" /label="downshifts" S_feature complement(2327112..2327238) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2327220..2327239) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2327238) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="upshifts" S_feature complement(2327240..2327370) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2327254..2327261) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2327365..2327384) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2327374) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2327398..2327401) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2327496..2327505 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2327519..2327538 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2327521 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="upshifts" CDS 2327559..2327894 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" /label="cotQ CDS" gene 2327559..2327894 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /label="cotQ gene" downshifts 2327888 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-35 2327975..2327982 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2327996..2328015 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2327998..2328062 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2327998 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="upshifts" CDS 2328063..2328518 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" /label="ysnE CDS" gene 2328063..2328518 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /label="ysnE gene" promotor_-35 2328626..2328632 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2328646..2328664 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2328653 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="upshifts" CDS 2328702..2329523 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" /label="ysnF CDS" gene 2328702..2329523 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /label="ysnF gene" downshifts 2329516 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts 2329580 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" /label="downshifts" tRNA complement(2329587..2329660) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg2 tRNA" gene complement(2329587..2329660) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /label="trnSL-Arg2 gene" downshifts complement(2329621) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2329697..2329716) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2329700) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2329730..2329737) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2329791..2330300) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" /label="ysnB CDS" gene complement(2329791..2330300) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /label="ysnB gene" downshifts complement(2329808) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" /label="downshifts" CDS complement(2330316..2330912) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" /label="rdgB CDS" gene complement(2330316..2330912) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /label="rdgB gene" CDS complement(2330925..2331662) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" /label="rph CDS" gene complement(2330925..2331662) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /label="rph gene" promotor_-10 complement(2331744..2331763) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2331760) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2331773..2332873) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" /label="gerM CDS" gene complement(2331773..2332873) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /label="gerM gene" promotor_-35 complement(2331778..2331783) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2331790) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2332896..2332914) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2332912) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2332929..2332934) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2332988..2333806) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" /label="rcmE CDS" gene complement(2332988..2333806) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /label="rcmE gene" downshifts complement(2333000) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2333814..2334254) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" /label="ysmB CDS" gene complement(2333814..2334254) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /label="ysmB gene" promotor_-10 complement(2334297..2334316) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2334306) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2334308..2334450) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2334332..2334336) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2334495) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" CDS complement(2334498..2334722) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" /label="gerE CDS" gene complement(2334498..2334722) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /label="gerE gene" upshifts 2334771 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2334773..2334791 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2334780..2334799) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2334800) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2334813..2334822) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2334838..2335281) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" /label="ysmA CDS" gene complement(2334838..2335281) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /label="ysmA gene" CDS complement(2335342..2336103) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" /label="sdhB CDS" gene complement(2335342..2336103) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /label="sdhB gene" downshifts complement(2335350) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2336106..2337866) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" /label="sdhA CDS" gene complement(2336106..2337866) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /label="sdhA gene" CDS complement(2337900..2338508) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" /label="sdhC CDS" gene complement(2337900..2338508) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /label="sdhC gene" promotor_-35 2338278..2338285 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2338298..2338317 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2338300 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2338509..2338604) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2338594..2338613) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2338604) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="upshifts" S_feature complement(2338606..2339227) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2338628..2338635) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2338743..2338747 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2338757..2338857 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2338764..2338783 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2338773 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" CDS 2338801..2339247 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" /label="yslB CDS" gene 2338801..2339247 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /label="yslB gene" upshifts 2338817 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" downshifts 2339235 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2339273) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" /label="downshifts" CDS complement(2339291..2340517) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" /label="lysCA CDS" CDS complement(2339291..2339782) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" /label="lysCB CDS" gene complement(2339291..2340517) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /label="lysCA gene" gene complement(2339291..2339782) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /label="lysCB gene" downshifts complement(2340631) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" /label="downshifts" misc_RNA complement(2340643..2340822) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" /label="kswC RNA" gene complement(2340643..2340822) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /label="kswC gene" downshifts complement(2340675) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2340847..2340866) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2340854) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="upshifts" promotor_-35 complement(2340879..2340886) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2340887..2342659) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" /label="uvrC CDS" gene complement(2340887..2342659) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /label="uvrC gene" promotor_-10 complement(2342686..2342705) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2342700) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="upshifts" promotor_-35 complement(2342719..2342726) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2342789) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" /label="downshifts" CDS complement(2342795..2343109) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" /label="trxA CDS" gene complement(2342795..2343109) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /label="trxA gene" promotor_-10 complement(2343135..2343154) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2343149) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2343151..2343360) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2343170..2343172) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2343254..2343364) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" /label="CDS C-terminal fragment" gene complement(2343254..2343364) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo /label="gene" promotor_-10 complement(2343350..2343368) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2343360) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="upshifts" promotor_-35 complement(2343383..2343389) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2343432..2344919) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" /label="abfB CDS" gene complement(2343432..2344919) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /label="abfB gene" S_feature complement(2344920..2345032) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2345013..2345032) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2345032) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="upshifts" promotor_-35 complement(2345047..2345054) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2345136..2346113) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" /label="etfA CDS" gene complement(2345136..2346113) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /label="etfA gene" downshifts complement(2345144) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2346149..2346922) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" /label="etfB CDS" gene complement(2346149..2346922) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /label="etfB gene" CDS complement(2346937..2347713) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" /label="fadB CDS" gene complement(2346937..2347713) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /label="fadB gene" downshifts 2347002 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" /label="downshifts" CDS complement(2347728..2348312) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" /label="fadR CDS" gene complement(2347728..2348312) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /label="fadR gene" promotor_-10 complement(2348354..2348373) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2348354) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2348386..2348393) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2348417..2350099) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" /label="lcfA CDS" gene complement(2348417..2350099) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /label="lcfA gene" misc_feature complement(2350128..2350147) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2350136) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2350224) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2350288..2350692) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" /label="yshE CDS" gene complement(2350288..2350692) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /label="yshE gene" downshifts complement(2350290) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2350707..2353064) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" /label="mutSB CDS" gene complement(2350707..2353064) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /label="mutSB gene" CDS complement(2353085..2354797) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" /label="polX CDS" gene complement(2353085..2354797) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /label="polX gene" S_feature complement(2354798..2354870) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2354871..2355404) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" /label="yshB CDS" gene complement(2354871..2355404) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /label="yshB gene" CDS complement(2355411..2355668) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" /label="zapA CDS" gene complement(2355411..2355668) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /label="zapA gene" promotor_-10 complement(2355695..2355714) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2355711) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2355726..2355733) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2355751..2355770 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2355758 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="upshifts" CDS 2355802..2356743 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" /label="rnhC CDS" gene 2355802..2356743 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /label="rnhC gene" promotor_-10 complement(2356475..2356494) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2356490) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2356508..2356515) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2356726 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2356758) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2356779..2359193) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" /label="pheT CDS" gene complement(2356779..2359193) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /label="pheT gene" downshifts complement(2356802) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2359209..2360243) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" /label="pheS CDS" gene complement(2359209..2360243) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /label="pheS gene" S_feature complement(2360244..2360564) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2360325..2360531 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" /label="hypothetical protein CDS" gene 2360325..2360531 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /label="gene" S_feature 2360554..2360818 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2360554 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2360559..2360578) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2360561..2360575 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2360564) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2360593..2360596) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2360598..2361344) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" /label="rlmBB CDS" gene complement(2360598..2361344) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /label="rlmBB gene" promotor_-10 complement(2361371..2361390) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2361377..2361383 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2361384) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="upshifts" promotor_-10 2361397..2361408 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2361404..2361410) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2361411 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2361463..2361678 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" /label="sspI CDS" gene 2361463..2361678 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /label="sspI gene" S_feature complement(2361660..2363072) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2361689..2361696 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2361712..2361731 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2361720 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2361747..2362853 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" /label="ysfB CDS" gene 2361747..2362853 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /label="ysfB gene" promotor_-35 2362889..2362892 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2362908..2362927 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2362912 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="upshifts" CDS 2362956..2364368 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" /label="glcD CDS" gene 2362956..2364368 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /label="glcD gene" promotor_-10 complement(2363058..2363077) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2363072) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2363090..2363099) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2364365..2365699 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" /label="glcF CDS" gene 2364365..2365699 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /label="glcF gene" Polymorphism join(2365398,2365400) /Source="geneious" /ID="SNP_BsDelta6_2935628_2935628" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=1035 /Change="C -> T" /Codon_Change="CTC -> CTT" /Coverage=142 /locus_tag="BSU_28690" /Protein_Effect="None" /Reference_Frequency="1.4%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=140 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2365697 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" downshifts complement(2365736) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2365738..2365980) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" /label="ysfE CDS" gene complement(2365738..2365980) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /label="ysfE gene" S_feature complement(2365981..2366152) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2366040..2366210) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" /label="hypothetical protein CDS" gene complement(2366040..2366210) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /label="gene" CDS complement(2366153..2367949) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" /label="cstA CDS" gene complement(2366153..2367949) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /label="cstA gene" promotor_-10 complement(2366255..2366273) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2366273) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2366285..2366293) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2367946 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2367974..2367993) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2367984) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2368008..2368014) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2368044..2368100) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2368068) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2368101..2369603) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" /label="abfA CDS" gene complement(2368101..2369603) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /label="abfA gene" downshifts complement(2369474) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2369578..2369678) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2369618) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2369622..2370467) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" /label="araQ CDS" gene complement(2369622..2370467) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /label="araQ gene" CDS complement(2370468..2371409) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" /label="araP CDS" gene complement(2370468..2371409) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /label="araP gene" CDS complement(2371445..2372746) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" /label="araN CDS" gene complement(2371445..2372746) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /label="araN gene" CDS complement(2372777..2373961) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" /label="egsA CDS" gene complement(2372777..2373961) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /label="egsA gene" CDS complement(2373958..2374776) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" /label="araL CDS" gene complement(2373958..2374776) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /label="araL gene" CDS complement(2374754..2375443) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" /label="araD CDS" gene complement(2374754..2375443) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /label="araD gene" CDS complement(2375460..2377142) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" /label="araB CDS" gene complement(2375460..2377142) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /label="araB gene" CDS complement(2377156..2378646) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" /label="araA CDS" gene complement(2377156..2378646) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /label="araA gene" promotor_-10 complement(2378739..2378758) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2378746) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2378748..2378823) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2378773..2378780) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2378824..2379795) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" /label="abnA CDS" gene complement(2378824..2379795) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /label="abnA gene" S_feature complement(2379796..2379924) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2379909..2379928) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2379924) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2379943..2379946) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2379992..2381077) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" /label="frvX CDS" gene complement(2379992..2381077) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /label="frvX gene" downshifts complement(2380006) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2381103..2381122) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2381126) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2381137..2381144) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2381195..2381204 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2381210 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2381216..2381231 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2381261..2381653 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" /label="ysdB CDS" gene 2381261..2381653 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /label="ysdB gene" downshifts 2381624 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" /label="downshifts" S_feature 2381669..2381975 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2381669..2381938) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" /label="ysdA CDS" gene complement(2381669..2381938) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /label="ysdA gene" downshifts complement(2381685) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" downshifts complement(2381854) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2381932 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" CDS complement(2381995..2382354) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" /label="rplT CDS" gene complement(2381995..2382354) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /label="rplT gene" downshifts complement(2382008) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(2382386..2382586) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" /label="rpmI CDS" gene complement(2382386..2382586) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /label="rpmI gene" CDS complement(2382599..2383120) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" /label="infC CDS" gene complement(2382599..2383120) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /label="infC gene" misc_RNA complement(2383182..2383321) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" /label="mRNA L20 leader attenuator sequence" gene complement(2383182..2383321) /locus_tag="BSU_misc_RNA_47" /label="gene" promotor_-10 complement(2383318..2383337) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2383328) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2383330..2383394) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2383351..2383358) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2383376..2383395) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2383394) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2383411..2383415) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2383513..2383520 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2383534..2383552 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2383534 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="upshifts" CDS 2383566..2384231 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" /label="yscB CDS" gene 2383566..2384231 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /label="yscB gene" downshifts 2384209 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2384263..2384958) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" /label="pftB CDS" gene complement(2384263..2384958) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /label="pftB gene" downshifts complement(2384285) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2384329) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2384980..2385420) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" /label="pftA CDS" gene complement(2384980..2385420) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /label="pftA gene" promotor_-10 complement(2385442..2385461) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2385461) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2385477..2385480) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2385554..2386279) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" /label="lytT CDS" gene complement(2385554..2386279) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /label="lytT gene" downshifts complement(2385583) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" /label="downshifts" CDS complement(2386257..2388038) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" /label="lytS CDS" gene complement(2386257..2388038) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /label="lytS gene" promotor_-35 2388122..2388125 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2388134..2388153) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2388139) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2388140..2388159 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2388147 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2388205..2388987 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" /label="ysaA CDS" gene 2388205..2388987 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /label="ysaA gene" downshifts 2388971 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" downshifts complement(2389021) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2389028..2390959) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" /label="thrS CDS" gene complement(2389028..2390959) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /label="thrS gene" misc_RNA complement(2391003..2391250) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboT RNA" gene complement(2391003..2391250) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /label="tboT gene" promotor_-10 complement(2391006..2391015) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2391006) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2391061) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2391261..2391280) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2391274) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2391276..2391356) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2391296..2391300) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2391357..2392202) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" /label="ytxC CDS" gene complement(2391357..2392202) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /label="ytxC gene" promotor_-10 complement(2392222..2392240) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2392228) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2392256..2392261) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2392281..2392922) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" /label="ytxB CDS" gene complement(2392281..2392922) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /label="ytxB gene" CDS complement(2392956..2393891) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" /label="dnaI CDS" gene complement(2392956..2393891) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /label="dnaI gene" CDS complement(2393919..2395337) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" /label="dnaB CDS" gene complement(2393919..2395337) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /label="dnaB gene" promotor_-10 complement(2395366..2395385) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2395374) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2395400..2395403) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2395452..2395910) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" /label="nrdR CDS" gene complement(2395452..2395910) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /label="nrdR gene" downshifts complement(2395471) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2395911..2396058) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2396049..2396068) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2396058) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="upshifts" S_feature complement(2396060..2396138) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2396083..2396086) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2396183) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" CDS complement(2396184..2396564) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" /label="speD CDS" gene complement(2396184..2396564) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /label="speD gene" S_feature complement(2396565..2396719) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2396699..2396718) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2396706 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2396707..2396726 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2396719) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2396733..2396739) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2396797..2396808) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2396803..2397825) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" /label="gapB CDS" gene complement(2396803..2397825) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /label="gapB gene" upshifts complement(2396804) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2396823..2396829) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2397869..2397888) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2397900) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2397901..2397908) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2398031..2398411) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" /label="ytcD CDS" gene complement(2398031..2398411) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /label="ytcD gene" downshifts complement(2398055) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(2398412..2398542) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2398467..2398471 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2398487..2398506 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2398488..2398594 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2398488 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2398532..2398551) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2398542) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2398566..2398573) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2398595..2399785 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" /label="ytbD CDS" gene 2398595..2399785 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /label="ytbD gene" promotor_-10 complement(2399417..2399435) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2399433) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2399451..2399456) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2399809..2400651 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" /label="ytbE CDS" gene 2399809..2400651 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /label="ytbE gene" promotor_-35 2400424..2400429 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2400445..2400463 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2400446 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2400644 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2400684) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2400693..2401286) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" /label="coaE CDS" gene complement(2400693..2401286) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /label="coaE gene" CDS complement(2401302..2401934) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" /label="spcF CDS" gene complement(2401302..2401934) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /label="spcF gene" S_feature complement(2401935..2402099) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2402100..2402930) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" /label="mutM CDS" gene complement(2402100..2402930) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /label="mutM gene" CDS complement(2402953..2405595) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" /label="polA CDS" gene complement(2402953..2405595) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /label="polA gene" promotor_-10 complement(2405650..2405669) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2405659) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2405683..2405690) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2405719..2405838) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2405762) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2405839..2407578) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" /label="phoR CDS" gene complement(2405839..2407578) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /label="phoR gene" CDS complement(2407571..2408293) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" /label="phoP CDS" gene complement(2407571..2408293) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /label="phoP gene" promotor_-10 complement(2408361..2408380) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2408371) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2408373..2408473) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2408394..2408400) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2408505..2409443) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" /label="mdh CDS" gene complement(2408505..2409443) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /label="mdh gene" downshifts complement(2408518) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2409487..2410758) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" /label="icd CDS" gene complement(2409487..2410758) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /label="icd gene" misc_feature complement(2410543..2410562) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2410555) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2410759..2410841) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2410841) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="upshifts" S_feature complement(2410843..2410921) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2410843..2410862) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2410878..2410882) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2410922..2412040) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" /label="citZ CDS" gene complement(2410922..2412040) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /label="citZ gene" downshifts 2411535 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" misc_feature 2411882..2411885 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2411890 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2412019 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2412041..2412247) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2412215..2412227 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2412226 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2412233..2412252) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2412247) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2412267..2412271) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2412367) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" /label="downshifts" CDS complement(2412374..2412838) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" /label="ytwI CDS" gene complement(2412374..2412838) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /label="ytwI gene" promotor_-10 complement(2412851..2412870) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2412865) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2412867..2414052) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2412867..2412872 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2412883..2412891) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2412887..2412905 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2412893 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="upshifts" CDS 2412935..2414050 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" /label="ytvI CDS" gene 2412935..2414050 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /label="ytvI gene" downshifts 2414021 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2414083..2414466) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" /label="ytzA CDS" gene complement(2414083..2414466) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /label="ytzA gene" downshifts complement(2414097) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2414467..2414558) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2414559..2416316) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" /label="pyk CDS" gene complement(2414559..2416316) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /label="pyk gene" CDS complement(2416359..2417318) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" /label="pfkA CDS" gene complement(2416359..2417318) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /label="pfkA gene" S_feature complement(2417319..2417420) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2417409..2417428) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2417420) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2417444..2417448) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2417502..2418479) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" /label="accA CDS" gene complement(2417502..2418479) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /label="accA gene" downshifts complement(2417529) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2418464..2419336) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" /label="accD CDS" gene complement(2418464..2419336) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /label="accD gene" promotor_-35 2419298..2419303 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2419319..2419337 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2419323..2420497 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2419323 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2419337..2419420) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2419409..2419428) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2419420) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2419422..2419574) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2419444..2419448) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2419576..2419670) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2419619) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" /label="downshifts" CDS complement(2419671..2420903) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" /label="maeB CDS" gene complement(2419671..2420903) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /label="maeB gene" S_feature complement(2420904..2421020) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2421008..2421027) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2421020) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" CDS complement(2421040..2424387) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" /label="dnaEC CDS" gene complement(2421040..2424387) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /label="dnaEC gene" promotor_-35 complement(2421041..2421048) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2422052..2422061 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2422073..2422088 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2422073 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2422261..2422280) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2422280) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2422294..2422301) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2424418..2424437) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2424436) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" promotor_-35 complement(2424451..2424458) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2424476..2424481 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2424493 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="upshifts" promotor_-10 2424497..2424515 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2424527..2424868 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" /label="ytrH CDS" gene 2424527..2424868 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /label="ytrH gene" CDS 2424865..2425368 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" /label="ytrI CDS" gene 2424865..2425368 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /label="ytrI gene" promotor_-35 2425401..2425404 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2425419..2425438 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2425419 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" CDS 2425470..2425661 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" /label="ytzJ CDS" gene 2425470..2425661 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /label="ytzJ gene" downshifts complement(2425471) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" /label="downshifts" downshifts 2425637 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2425679..2426620) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" /label="nrnA CDS" gene complement(2425679..2426620) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /label="nrnA gene" S_feature 2425682..2426053 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2425714) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2426022..2426031 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2426045..2426064 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2426055..2426449 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2426055 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2426411..2426417 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2426433..2426452 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2426451..2426750 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2426451 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2426639..2426658) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2426655) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2426657..2427071) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2426673..2426676) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2426751..2427053 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" /label="ytpI CDS" gene 2426751..2427053 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /label="ytpI gene" S_feature 2427054..2428849 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2427072..2428391) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" /label="ytoI CDS" gene complement(2427072..2428391) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /label="ytoI gene" promotor_-10 complement(2428417..2428436) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2428438) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2428451..2428456) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2428567..2429469) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" /label="ytnM CDS" gene complement(2428567..2429469) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /label="ytnM gene" CDS complement(2429488..2430738) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" /label="sndA CDS" gene complement(2429488..2430738) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /label="sndA gene" CDS complement(2430756..2431448) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" /label="ribR CDS" gene complement(2430756..2431448) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /label="ribR gene" CDS complement(2431495..2432823) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" /label="cmoJ CDS" gene complement(2431495..2432823) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /label="cmoJ gene" CDS complement(2432820..2433101) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" /label="cmoI CDS" gene complement(2432820..2433101) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /label="cmoI gene" CDS complement(2433116..2434120) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" /label="cmoO CDS" gene complement(2433116..2434120) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /label="cmoO gene" CDS complement(2434117..2434896) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" /label="tcyN CDS" gene complement(2434117..2434896) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /label="tcyN gene" CDS complement(2434893..2435600) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" /label="tcyM CDS" gene complement(2434893..2435600) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /label="tcyM gene" CDS complement(2435630..2436349) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" /label="tcyL CDS" gene complement(2435630..2436349) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /label="tcyL gene" promotor_-35 2436175..2436182 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2436197..2436216 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2436197 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2436371..2437183) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" /label="tcyK CDS" gene complement(2436371..2437183) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /label="tcyK gene" CDS complement(2437197..2438006) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" /label="tcyJ CDS" gene complement(2437197..2438006) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /label="tcyJ gene" CDS complement(2438020..2438556) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" /label="snaA CDS" gene complement(2438020..2438556) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /label="snaA gene" promotor_-35 2438593..2438600 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2438611..2438630) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2438614..2438633 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2438617..2438708 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2438617 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2438627) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2438644..2438651) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2438709..2439635 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" /label="ascR CDS" gene 2438709..2439635 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /label="ascR gene" S_feature complement(2439111..2439640) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2439685) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" /label="downshifts" CDS complement(2439686..2440369) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" /label="ytkL CDS" gene complement(2439686..2440369) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /label="ytkL gene" S_feature complement(2440370..2440431) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2440432..2441199) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" /label="ytkK CDS" gene complement(2440432..2441199) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /label="ytkK gene" promotor_-10 complement(2441244..2441263) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2441266) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2441279..2441281) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2441326..2441562) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" /label="ytzD CDS" gene complement(2441326..2441562) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /label="ytzD gene" downshifts 2441411 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" /label="downshifts" downshifts complement(2441431) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" /label="downshifts" CDS complement(2441522..2442907) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" /label="argH CDS" gene complement(2441522..2442907) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /label="argH gene" CDS complement(2442904..2444115) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" /label="argG CDS" gene complement(2442904..2444115) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /label="argG gene" S_feature complement(2444116..2444193) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2444186..2444205) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2444192) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2444220..2444227) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2444285..2444797) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" /label="moaB CDS" gene complement(2444285..2444797) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /label="moaB gene" downshifts complement(2444303) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2444823..2444842) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2444831) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2444856..2444863) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2444882..2446069) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" /label="ackA CDS" gene complement(2444882..2446069) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /label="ackA gene" downshifts complement(2444897) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" /label="downshifts" S_feature complement(2446070..2446174) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2446159..2446178) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2446174) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2446176..2446305) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2446194..2446198) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2446242..2446445) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" /label="hypothetical protein CDS" gene complement(2446242..2446445) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /label="gene" promotor_-10 complement(2446303..2446314) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2446305) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2446329..2446335) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2446417..2447406) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" /label="ytxK CDS" gene complement(2446417..2447406) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /label="ytxK gene" downshifts complement(2446435) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2447467..2447970) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" /label="tpx CDS" gene complement(2447467..2447970) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /label="tpx gene" downshifts complement(2447473) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" /label="downshifts" promotor_no_box 2447687..2447787 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2447747 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2447966 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2447993..2448012) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2448009) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2448026..2448033) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2448080..2448535) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" /label="gerW CDS" gene complement(2448080..2448535) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /label="gerW gene" downshifts complement(2448108) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" CDS complement(2448549..2449229) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" /label="ytfI CDS" gene complement(2448549..2449229) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /label="ytfI gene" upshifts complement(2448641) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="upshifts" promotor_-10 complement(2448648..2448659) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2448674..2448680) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2448967) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2449242..2449260) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2449256) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="upshifts" promotor_-35 complement(2449275..2449280) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2449304..2449798) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" /label="yteJ CDS" gene complement(2449304..2449798) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /label="yteJ gene" downshifts complement(2449319) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2449811..2450818) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" /label="sppA CDS" gene complement(2449811..2450818) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /label="sppA gene" promotor_-10 complement(2450842..2450857) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2450859) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2450861..2450940) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2450869..2450878) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2450918..2450937 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2450928 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2450933..2450952) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2450937..2451003 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2450940) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2450968..2450972) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2451004..2451807 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" /label="ppnKB CDS" gene 2451004..2451807 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /label="ppnKB gene" downshifts 2451737 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" /label="downshifts" downshifts 2451795 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2451839..2453428) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" /label="ytcJ CDS" gene complement(2451839..2453428) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /label="ytcJ gene" downshifts complement(2451848) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2453448..2455037) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" /label="ytcI CDS" gene complement(2453448..2455037) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /label="ytcI gene" promotor_-10 complement(2455083..2455100) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2455088) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2455116..2455122) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2455215) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2455216..2455425) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" /label="sspA CDS" gene complement(2455216..2455425) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /label="sspA gene" promotor_-35 2455421..2455425 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2455425 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2455434..2455448 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2455446..2455457) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2455457) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2455472..2455478) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2455519..2456724) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" /label="trmG CDS" gene complement(2455519..2456724) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /label="trmG gene" CDS complement(2456728..2457873) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" /label="iscSB CDS" gene complement(2456728..2457873) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /label="iscSB gene" S_feature complement(2457874..2459017) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2457960..2457967 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2457978..2458067 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2457978 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2457980..2457999 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2458068..2459405 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" /label="braB CDS" gene 2458068..2459405 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /label="braB gene" promotor_-10 complement(2459003..2459022) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2459017) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2459037..2459044) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2459381 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2459500..2461188) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" /label="ezrA CDS" gene complement(2459500..2461188) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /label="ezrA gene" downshifts complement(2459501) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2461189..2461294) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2461271..2461279 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2461282..2461301) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2461290..2461309 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2461294) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" upshifts 2461294 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2461295..2461384 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2461296..2461855) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2461317..2461319) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2461385..2462191 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" /label="hisK CDS" gene 2461385..2462191 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /label="hisK gene" promotor_-10 complement(2461859..2461878) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2461872) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2461890..2461897) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2462141..2462187) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2462163) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2462188..2462811) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" /label="refZ CDS" gene complement(2462188..2462811) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /label="refZ gene" S_feature 2462192..2462534 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2462512..2462519 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2462534..2462553 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2462536..2462679 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2462536 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2462651..2462655 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2462671..2462690 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2462681..2462811 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2462681 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2462813..2462937 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2462813 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2462827..2462845) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2462829..2462848 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2462845) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2462856..2462864) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2462938..2463429 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" /label="msrC CDS" gene 2462938..2463429 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /label="msrC gene" downshifts 2463408 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2463467..2465206) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" /label="dgcP CDS" gene complement(2463467..2465206) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /label="dgcP gene" downshifts complement(2463485) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" promotor_-35 2464680..2464687 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2464701..2464719 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2464704 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="upshifts" S_feature 2464706..2465301 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2465236..2465255) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2465244) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2465246..2466079) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2465282..2465289 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2465303..2465500 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2465303..2465322 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2465303 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2465360..2465492 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" /label="ldsD RNA" gene 2465360..2465492 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /label="ldsD gene" CDS 2465501..2466103 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" /label="rpsD CDS" gene 2465501..2466103 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /label="rpsD gene" downshifts 2466026 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(2466081..2466300) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2466089 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" /label="downshifts" downshifts complement(2466124) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2466136 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2466181..2466354 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2466296..2466314) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2466308) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="upshifts" downshifts 2466312 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2466329..2466335) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2466374..2467642) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" /label="tyrS CDS" gene complement(2466374..2467642) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /label="tyrS gene" downshifts complement(2466400) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" misc_RNA complement(2467666..2467939) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" /label="tboY RNA" gene complement(2467666..2467939) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /label="tboY gene" S_feature complement(2467687..2467830) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2467730) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2467937..2467956) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2467949) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2467969..2467976) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2467984..2469702) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" /label="acsA CDS" gene complement(2467984..2469702) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /label="acsA gene" promotor_-35 2469716..2469723 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2469730..2469749) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2469738..2469757 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2469744 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2469753) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2469763..2469769) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2469786..2469793 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2469807..2469826 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2469810 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2469863..2470495 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" /label="acuA CDS" gene 2469863..2470495 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /label="acuA gene" promotor_-35 2470068..2470076 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2470090..2470109 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2470096 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2470522..2471166 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" /label="acuB CDS" gene 2470522..2471166 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /label="acuB gene" CDS 2471163..2472326 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" /label="acuC CDS" gene 2471163..2472326 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /label="acuC gene" downshifts 2472317 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2472337..2473065) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" /label="motS CDS" gene complement(2472337..2473065) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /label="motS gene" downshifts complement(2472373) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2473055..2473873) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" /label="motP CDS" gene complement(2473055..2473873) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /label="motP gene" CDS complement(2473936..2474940) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" /label="ccpA CDS" gene complement(2473936..2474940) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /label="ccpA gene" downshifts complement(2473953) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(2474975..2474994) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2474990) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2474992..2475100) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2475100..2475119) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2475100) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2475102..2475167) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2475133..2475139) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2475213) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2475216..2476292) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" /label="aroX CDS" gene complement(2475216..2476292) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /label="aroX gene" promotor_-10 complement(2476333..2476352) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2476353) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="upshifts" S_feature complement(2476355..2476455) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2476367..2476374) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2476389 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2476443..2476462) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2476455) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2476476..2476482) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2476528..2476854) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" /label="brxJ CDS" gene complement(2476528..2476854) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /label="brxJ gene" downshifts complement(2476537) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2476878..2477333) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" /label="ytxH CDS" gene complement(2476878..2477333) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /label="ytxH gene" CDS complement(2477364..2477786) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" /label="ytxG CDS" gene complement(2477364..2477786) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /label="ytxG gene" promotor_-10 complement(2477807..2477825) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2477820) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2477839..2477845) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2477859..2477877) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2477868) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="upshifts" promotor_-35 complement(2477888..2477896) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2477948..2479246) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" /label="murC CDS" gene complement(2477948..2479246) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /label="murC gene" downshifts complement(2477957) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2479271..2479290) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2479272) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2479274..2479470) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2479303..2479312) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2479453..2479472) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2479470) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2479484..2479490) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2479496..2482354) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" /label="sftA CDS" gene complement(2479496..2482354) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /label="sftA gene" promotor_-10 complement(2482388..2482407) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2482398) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="upshifts" promotor_-35 complement(2482423..2482427) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2482497) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" /label="downshifts" CDS complement(2482514..2483119) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" /label="ytpR CDS" gene complement(2482514..2483119) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /label="ytpR gene" CDS complement(2483135..2483944) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" /label="ytpQ CDS" gene complement(2483135..2483944) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /label="ytpQ gene" CDS complement(2483959..2484282) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" /label="ytpP CDS" gene complement(2483959..2484282) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /label="ytpP gene" S_feature complement(2484283..2484421) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2484321..2484437) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" /label="hypothetical protein CDS" gene complement(2484321..2484437) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /label="gene" promotor_-10 complement(2484408..2484427) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2484421) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="upshifts" promotor_-35 2484429..2484436 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2484451..2484470 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2484456 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="upshifts" CDS 2484517..2484963 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" /label="ytoQ CDS" gene 2484517..2484963 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /label="ytoQ gene" S_feature 2484964..2485692 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2485018..2486091) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" /label="ytoP CDS" gene complement(2485018..2486091) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /label="ytoP gene" downshifts complement(2485037) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2486113..2486132) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2486117) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2486146..2486153) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2486188..2486191 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2486206..2486225 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2486211 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="upshifts" CDS 2486250..2486567 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" /label="ytzB CDS" gene 2486250..2486567 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /label="ytzB gene" downshifts 2486567 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2486620..2488320) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" /label="maeC CDS" gene complement(2486620..2488320) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /label="maeC gene" downshifts complement(2486639) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2488352..2488370) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2488359) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2488385..2488391) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2488402..2489172) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" /label="ytnP CDS" gene complement(2488402..2489172) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /label="ytnP gene" S_feature complement(2489173..2489261) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2489259..2489278) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2489261) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2489294..2489298) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2489318..2489959) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" /label="trmB CDS" gene complement(2489318..2489959) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /label="trmB gene" downshifts complement(2489328) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(2489393) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2489985..2490004) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2489994) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2489996..2490444) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2490020..2490024) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2490103..2490109 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2490124..2490135 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2490131 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="upshifts" CDS 2490166..2490444 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" /label="ytzH CDS" gene 2490166..2490444 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /label="ytzH gene" S_feature 2490445..2490615 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2490445..2491059) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" /label="ytmP CDS" gene complement(2490445..2491059) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /label="ytmP gene" downshifts 2490593 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2491060..2491395) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2491387..2491406) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2491395) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2491421..2491428) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2491422..2493578) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" /label="amyX CDS" gene complement(2491422..2493578) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /label="amyX gene" Polymorphism join(2493119,2493121) /Source="geneious" /ID="SNP_BsDelta6_3063349_3063349" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=459 /Change="A -> G" /Codon_Change="GTT -> GTC" /Coverage=168 /locus_tag="BSU_29930" /Protein_Effect="None" /Reference_Frequency="1.2%" /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=165 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2493604..2494533) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" /label="ytlR CDS" gene complement(2493604..2494533) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /label="ytlR gene" CDS complement(2494582..2495496) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" /label="ytlQ CDS" gene complement(2494582..2495496) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /label="ytlQ gene" promotor_-10 complement(2495259..2495277) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2495267) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2495291..2495297) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2495522..2496073) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" /label="ytlP CDS" gene complement(2495522..2496073) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /label="ytlP gene" misc_feature 2495936..2495955 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2495939 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2496096..2496115) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2496108) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2496131..2496134) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2496156..2496163 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2496174..2496193 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2496177..2496188) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2496181 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2496191) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2496202..2496208) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2496222..2497157 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" /label="ytkP CDS" gene 2496222..2497157 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /label="ytkP gene" downshifts 2497133 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(2497191..2498582) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" /label="ytjP CDS" gene complement(2497191..2498582) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /label="ytjP gene" downshifts complement(2497203) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature complement(2498583..2499023) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2498609..2498614 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2498628..2498647 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2498641 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="upshifts" CDS 2498679..2499977 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" /label="pbuO CDS" gene 2498679..2499977 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /label="pbuO gene" promotor_-10 complement(2499000..2499019) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2499023) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2499034..2499040) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2499964 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2500017..2501174) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" /label="ythQ CDS" gene complement(2500017..2501174) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /label="ythQ gene" downshifts complement(2500042) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2500290..2500295 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2500310..2500328 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2500318 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2501171..2501881) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" /label="ythP CDS" gene complement(2501171..2501881) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /label="ythP gene" promotor_-10 complement(2501895..2501910) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2501912) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2501922..2501931) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2501938..2501939 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2501951..2502056 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2501951 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2501959..2501969 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2502022..2502028 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2502043..2502062 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2502058..2502171 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2502058 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2502172..2502393 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" /label="ytzE CDS" gene 2502172..2502393 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /label="ytzE gene" downshifts 2502376 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" /label="downshifts" downshifts 2502445 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2502514..2503233) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" /label="rsuA CDS" gene complement(2502514..2503233) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /label="rsuA gene" downshifts complement(2502528) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2503299) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" /label="downshifts" CDS complement(2503302..2504936) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" /label="murJ CDS" gene complement(2503302..2504936) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /label="murJ gene" misc_feature complement(2504968..2504987) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2504984) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2505054..2505058 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2505074..2505093 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2505092 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2505138..2506400 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" /label="ytfP CDS" gene 2505138..2506400 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /label="ytfP gene" S_feature 2506401..2506499 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2506473..2506479 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2506495..2506513 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2506501..2506588 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2506501 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2506589..2508127 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" /label="opuD CDS" gene 2506589..2508127 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /label="opuD gene" downshifts 2508107 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2508164..2508346) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" /label="yteV CDS" gene complement(2508164..2508346) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /label="yteV gene" downshifts complement(2508183) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2508361..2508379) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2508381) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2508395..2508400) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2508414..2509082) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" /label="rmgU CDS" gene complement(2508414..2509082) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /label="rmgU gene" CDS complement(2509104..2510390) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" /label="rmgT CDS" gene complement(2509104..2510390) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /label="rmgT gene" CDS complement(2510402..2510905) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" /label="rmgS CDS" gene complement(2510402..2510905) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /label="rmgS gene" CDS complement(2510902..2512023) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" /label="rmgQ CDS" gene complement(2510902..2512023) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /label="rmgQ gene" CDS complement(2512031..2512996) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" /label="rmgP CDS" gene complement(2512031..2512996) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /label="rmgP gene" upshifts complement(2513022) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2513023..2513042) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2513057..2513064) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2513152..2513159 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2513172 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2513175..2513194 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2513212..2515530 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" /label="rmgR CDS" gene 2513212..2515530 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /label="rmgR gene" downshifts 2515520 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" CDS complement(2515571..2517067) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" /label="ytcQ CDS" gene complement(2515571..2517067) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /label="ytcQ gene" downshifts complement(2515573) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2517092..2517952) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" /label="ytcP CDS" gene complement(2517092..2517952) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /label="ytcP gene" promotor_-10 complement(2518028..2518047) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2518037) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2518063..2518070) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2518159..2518920) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" /label="ytbQ CDS" gene complement(2518159..2518920) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /label="ytbQ gene" downshifts complement(2518188) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2518921..2518996) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2518997..2520184) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" /label="bioI CDS" gene complement(2518997..2520184) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /label="bioI gene" CDS complement(2520253..2521260) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" /label="bioB CDS" gene complement(2520253..2521260) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /label="bioB gene" CDS complement(2521263..2521958) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" /label="bioD CDS" gene complement(2521263..2521958) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /label="bioD gene" CDS complement(2521955..2523124) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" /label="bioFC CDS" gene complement(2521955..2523124) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /label="bioFC gene" promotor_-35 2521991..2521998 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2522013..2522032 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2522031 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2523114..2524460) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" /label="bioK CDS" gene complement(2523114..2524460) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /label="bioK gene" promotor_-35 2523530..2523534 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2523549 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2523550..2523568 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2524450..2525226) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" /label="bioW CDS" gene complement(2524450..2525226) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /label="bioW gene" S_feature complement(2525227..2525319) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2525305..2525324) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2525319) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2525339..2525346) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2525436..2526335) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" /label="ytaP CDS" gene complement(2525436..2526335) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /label="ytaP gene" promotor_-10 complement(2526358..2526376) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2526375) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2526387..2526395) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2526465..2526472 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2526488..2526507 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2526494 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2526553..2527587 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" /label="msmR CDS" gene 2526553..2527587 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /label="msmR gene" promotor_-35 2527536..2527543 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2527558..2527566 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2527575 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2527621..2528901 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" /label="msmE CDS" gene 2527621..2528901 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /label="msmE gene" CDS 2528894..2529805 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" /label="msmF CDS" gene 2528894..2529805 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /label="msmF gene" CDS 2529802..2530632 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" /label="msmG CDS" gene 2529802..2530632 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /label="msmG gene" promotor_-35 2530605..2530609 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2530625..2530644 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2530633 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2530652..2531950 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" /label="melA CDS" gene 2530652..2531950 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /label="melA gene" downshifts 2531931 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2531972..2532283) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" /label="ytwF CDS" gene complement(2531972..2532283) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /label="ytwF gene" downshifts complement(2531983) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2532307..2532326) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2532315) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2532341..2532348) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2532349 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS complement(2532400..2534814) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" /label="leuS CDS" gene complement(2532400..2534814) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /label="leuS gene" downshifts complement(2532404) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" S_feature complement(2534815..2534910) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2534924..2535138) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" /label="tboL RNA" gene complement(2534924..2535138) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /label="tboL gene" downshifts complement(2534955) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2535150..2535169) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2535171) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2535175..2535180 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2535184..2535189) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2535196..2535214 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2535209..2535649 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2535209 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2535241..2535576) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" /label="ytvB CDS" gene complement(2535241..2535576) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /label="ytvB gene" S_feature complement(2535571..2535835) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2535820..2535839) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2535835) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="upshifts" promotor_-35 complement(2535854..2535861) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2535874..2535881 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2535895..2535914 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2535911 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2535913..2535980 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2535981..2536766 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" /label="blrA CDS" gene 2535981..2536766 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /label="blrA gene" S_feature 2536767..2536823 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2537003..2538196) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" /label="yttB CDS" gene complement(2537003..2538196) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /label="yttB gene" downshifts complement(2537023) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2538197..2538295) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2538276..2538295) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2538295) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2538309..2538316) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2538333..2538336 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2538351..2538370 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2538355 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="upshifts" CDS 2538385..2539131 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" /label="yttA CDS" gene 2538385..2539131 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /label="yttA gene" downshifts 2539026 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" /label="downshifts" downshifts 2539125 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2539168..2541108) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" /label="bceB CDS" gene complement(2539168..2541108) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /label="bceB gene" downshifts complement(2539179) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2541098..2541859) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" /label="bceA CDS" gene complement(2541098..2541859) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /label="bceA gene" misc_feature complement(2541883..2541901) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2541902) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2541961..2542965) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" /label="bceS CDS" gene complement(2541961..2542965) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /label="bceS gene" downshifts complement(2542000) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2542958..2543653) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" /label="bceR CDS" gene complement(2542958..2543653) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /label="bceR gene" promotor_-10 complement(2543677..2543695) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2543689) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2543711..2543714) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2543750..2545060) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" /label="ytrF CDS" gene complement(2543750..2545060) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /label="ytrF gene" downshifts complement(2543772) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" /label="downshifts" CDS complement(2545050..2545745) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" /label="ytrE CDS" gene complement(2545050..2545745) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /label="ytrE gene" CDS complement(2545760..2546737) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" /label="ytrD CDS" gene complement(2545760..2546737) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /label="ytrD gene" CDS complement(2546767..2547753) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" /label="ytrC CDS" gene complement(2546767..2547753) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /label="ytrC gene" promotor_-35 2547623..2547632 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2547639 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2547645..2547660 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2547747..2548625) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" /label="ytrB CDS" gene complement(2547747..2548625) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /label="ytrB gene" CDS complement(2548618..2549010) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" /label="ytrA CDS" gene complement(2548618..2549010) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /label="ytrA gene" S_feature complement(2549011..2549255) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2549044..2549181) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" /label="conserved protein of unknown function CDS" gene complement(2549044..2549181) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /label="gene" downshifts 2549179 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2549250..2549269) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2549255) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2549283..2549290) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2549336..2549608) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" /label="ytzC CDS" gene complement(2549336..2549608) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /label="ytzC gene" downshifts complement(2549343) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2549648..2549659) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2549652..2549660 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2549652) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="upshifts" upshifts 2549663 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2549674..2549680) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2549674..2549692 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2549703..2549708 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2549722..2549741 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2549729 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="upshifts" CDS 2549770..2550738 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" /label="ytqA CDS" gene 2549770..2550738 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /label="ytqA gene" CDS 2550735..2551319 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" /label="ytqB CDS" gene 2550735..2551319 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /label="ytqB gene" downshifts 2551283 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2551309..>2551440) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /modified_by="User" /translation="LAKKLIKASGKTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC* " /label="IIG_Bs13_pseudo_BSU_30500" gene complement(2551309..>2551440) /gene="tbcS" /locus_tag="IIG_Bs13_pseudo_BSU_30500" /old_locus_tag="BSU_30500" /modified_by="User" /label="IIG_Bs13_pseudo_BSU_30500" downshifts complement(2551350) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" SCAR 2551443..2551444 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs13" S_feature complement(<2551444..2551459) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" promotor_-10 complement(2551450..2551469) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2551459) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2551461..2551595) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2551481..2551488) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2551570..2551589) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2551595) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2551688..2553079) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" /label="ytnA CDS" gene complement(2551688..2553079) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /label="ytnA gene" downshifts complement(2551696) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(2553080..2553214) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2553215..2555113) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" /label="asnB CDS" gene complement(2553215..2555113) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /label="asnB gene" promotor_-35 2554271..2554277 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2554292..2554303 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2554304 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2555114..2555237) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2555263..2556465) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" /label="metK CDS" gene complement(2555263..2556465) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /label="metK gene" downshifts complement(2555282) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2556508..2556519) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2556514) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2556516..2556632) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2556533..2556539) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2556633..2556771) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswG RNA" gene complement(2556633..2556771) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /label="mswG gene" downshifts 2556731 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2556780..2556799) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2556795) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="upshifts" promotor_-35 complement(2556816..2556820) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2556892..2556899 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2556911 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2556913..2556932 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2556968..2558551 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" /label="pckA CDS" gene 2556968..2558551 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /label="pckA gene" downshifts 2558540 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" /label="downshifts" CDS complement(2558590..2558832) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" /label="ytmB CDS" gene complement(2558590..2558832) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /label="ytmB gene" downshifts complement(2558604) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2558884..2559657) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" /label="ytmA CDS" gene complement(2558884..2559657) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /label="ytmA gene" S_feature complement(2559658..2559748) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2559724..2559733 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2559737..2559756) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2559745 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2559746..2559765 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2559750) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2559771..2559778) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2559808..2560812 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" /label="ytlA CDS" gene 2559808..2560812 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /label="ytlA gene" CDS 2560825..2561607 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" /label="ytlC CDS" gene 2560825..2561607 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /label="ytlC gene" S_feature complement(2560829..2562377) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2561582..2562394 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" /label="ytlD CDS" gene 2561582..2562394 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /label="ytlD gene" downshifts 2562379 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(2562421..2562897) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" /label="rppG CDS" gene complement(2562421..2562897) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /label="rppG gene" downshifts complement(2562422) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" /label="downshifts" misc_feature complement(2562927..2562946) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2562940) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2562942..2563076) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2563076) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2563078..2563089) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2563104..2563110) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2563106..2563510) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" /label="ytkC CDS" gene complement(2563106..2563510) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /label="ytkC gene" promotor_-10 complement(2563538..2563557) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2563555) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2563557..2563643) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2563570..2563579) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2563676..2564113) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" /label="dps CDS" gene complement(2563676..2564113) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /label="dps gene" downshifts complement(2563688) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2564130..2564148) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2564148) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2564150..2564375) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2564163..2564169) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2564205..2564224 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2564206..2564382 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" /label="ytzI CDS" gene 2564206..2564382 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /label="ytzI gene" upshifts 2564207 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2564376..2564813) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" /label="ytkA CDS" gene complement(2564376..2564813) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /label="ytkA gene" downshifts 2564402 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2564832..2564851) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2564853) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 complement(2564862..2564870) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2564933..2565406) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" /label="luxS CDS" gene complement(2564933..2565406) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /label="luxS gene" downshifts complement(2564942) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" /label="downshifts" downshifts complement(2565029) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" S_feature complement(2565407..2565758) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2565478..2565485 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2565498..2565517 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2565503 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2565535..2565762 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" /label="ytjA CDS" gene 2565535..2565762 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /label="ytjA gene" CDS complement(2565759..2566322) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" /label="ytiB CDS" gene complement(2565759..2566322) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /label="ytiB gene" misc_feature complement(2566347..2566366) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2566362) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2566416..2566664) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" /label="rpmEB CDS" gene complement(2566416..2566664) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /label="rpmEB gene" downshifts complement(2566437) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2566692..2566711) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2566725..2566732) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2566729) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 2566791..2566797 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2566811..2566822 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2566823 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="upshifts" CDS 2566869..2568200 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" /label="ythA CDS" gene 2566869..2568200 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /label="ythA gene" CDS 2568244..2569284 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" /label="ythB CDS" gene 2568244..2569284 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /label="ythB gene" promotor_-35 2569278..2569284 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2569299..2569310 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2569309 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="upshifts" CDS 2569338..2569496 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" /label="ytzL CDS" gene 2569338..2569496 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /label="ytzL gene" downshifts 2569485 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2569515..2570402) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" /label="mntD CDS" gene complement(2569515..2570402) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /label="mntD gene" downshifts complement(2569538) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" CDS complement(2570392..2571699) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" /label="mntC CDS" gene complement(2570392..2571699) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /label="mntC gene" CDS complement(2571705..2572457) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" /label="mntB CDS" gene complement(2571705..2572457) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /label="mntB gene" CDS complement(2572476..2573396) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" /label="mntA CDS" gene complement(2572476..2573396) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /label="mntA gene" promotor_-10 complement(2573432..2573443) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2573433) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2573435..2573526) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2573457..2573463) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2573511 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2573512..2573531) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2573514..2573526 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2573526) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2573528..2573609) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2573546..2573553) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2573609) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="upshifts" promotor_-10 complement(2573618..2573637) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2573651..2573658) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2573676..2574791) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" /label="menC CDS" gene complement(2573676..2574791) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /label="menC gene" downshifts complement(2573719) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2574788..2576248) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" /label="menE CDS" gene complement(2574788..2576248) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /label="menE gene" promotor_-10 complement(2575691..2575709) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2575695) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2575724..2575730) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2576337) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS complement(2576339..2577154) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" /label="menB CDS" gene complement(2576339..2577154) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /label="menB gene" CDS complement(2577189..2578013) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" /label="menH CDS" gene complement(2577189..2578013) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /label="menH gene" promotor_-10 complement(2577271..2577290) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2577271) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2577306..2577309) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2577437) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2577447..2577458) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2577473..2577479) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2578001..2579743) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" /label="menD CDS" gene complement(2578001..2579743) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /label="menD gene" CDS complement(2579740..2581155) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" /label="menF CDS" gene complement(2579740..2581155) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /label="menF gene" S_feature complement(2581156..2581268) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2581248..2581267) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2581268) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="upshifts" S_feature complement(2581270..2581420) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2581283..2581286) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2581381..2581387 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2581401..2581420) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2581401..2581412 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2581409 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2581420) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2581434..2581443) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2581445..2582164 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" /label="yteA CDS" gene 2581445..2582164 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /label="yteA gene" S_feature complement(2581515..2582172) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2582153 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2582173..2582991) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" /label="ytdA CDS" gene complement(2582173..2582991) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /label="ytdA gene" promotor_-10 complement(2583012..2583031) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2583026) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2583046..2583054) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2583092..2583100 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2583113..2583132 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2583114 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="upshifts" CDS 2583163..2584449 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" /label="ytcA CDS" gene 2583163..2584449 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /label="ytcA gene" CDS 2584446..2585396 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" /label="ytcB CDS" gene 2584446..2585396 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /label="ytcB gene" CDS 2585399..2586622 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" /label="ytcC CDS" gene 2585399..2586622 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /label="ytcC gene" downshifts complement(2586546) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2586623..2587190 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2586696..2587127) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" /label="cotOO CDS" gene complement(2586696..2587127) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /label="cotOO gene" downshifts complement(2586722) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(2587129..2588184) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" /label="cotS CDS" gene complement(2587129..2588184) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /label="cotS gene" CDS complement(2588199..2589332) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" /label="cotSA CDS" gene complement(2588199..2589332) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /label="cotSA gene" promotor_-10 complement(2589365..2589384) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2589384) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2589397..2589406) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2589470..2589479 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2589493..2589512 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2589495 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="upshifts" CDS 2589522..2590595 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" /label="cotI CDS" gene 2589522..2590595 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /label="cotI gene" promotor_-35 2589819..2589825 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2589836 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2589839..2589850 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2590584 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2590622..2590628 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2590643 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2590644..2590662 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2590675..2591142 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" /label="ytaB CDS" gene 2590675..2591142 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /label="ytaB gene" downshifts 2591114 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2591173..2593569) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" /label="glgP CDS" gene complement(2591173..2593569) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /label="glgP gene" downshifts complement(2591188) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2593556..2595010) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" /label="glgA CDS" gene complement(2593556..2595010) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /label="glgA gene" CDS complement(2595007..2596038) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" /label="glgD CDS" gene complement(2595007..2596038) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /label="glgD gene" CDS complement(2596062..2597204) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" /label="glgC CDS" gene complement(2596062..2597204) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /label="glgC gene" CDS complement(2597201..2599084) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" /label="glgB CDS" gene complement(2597201..2599084) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /label="glgB gene" S_feature 2597910..2599329 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2599116..2599131) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2599129) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2599146..2599151) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2599196) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" /label="downshifts" tRNA complement(2599317..2599388) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Glu tRNA" gene complement(2599317..2599388) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /label="trnB-Glu gene" tRNA complement(2599414..2599504) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser2 tRNA" gene complement(2599414..2599504) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /label="trnB-Ser2 gene" tRNA complement(2599508..2599582) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asn tRNA" gene complement(2599508..2599582) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /label="trnB-Asn gene" tRNA complement(2599593..2599669) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ile2 tRNA" gene complement(2599593..2599669) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /label="trnB-Ile2 gene" tRNA complement(2599685..2599758) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly2 tRNA" gene complement(2599685..2599758) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /label="trnB-Gly2 gene" tRNA complement(2599769..2599844) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-His tRNA" gene complement(2599769..2599844) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /label="trnB-His gene" tRNA complement(2599862..2599937) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Phe tRNA" gene complement(2599862..2599937) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /label="trnB-Phe gene" tRNA complement(2599950..2600026) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asp tRNA" gene complement(2599950..2600026) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /label="trnB-Asp gene" tRNA complement(2600038..2600114) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met2 tRNA" gene complement(2600038..2600114) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /label="trnB-Met2 gene" tRNA complement(2600132..2600224) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser1 tRNA" gene complement(2600132..2600224) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /label="trnB-Ser1 gene" tRNA complement(2600231..2600307) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met3 tRNA" gene complement(2600231..2600307) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /label="trnB-Met3 gene" tRNA complement(2600310..2600386) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met1 tRNA" gene complement(2600310..2600386) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /label="trnB-Met1 gene" tRNA complement(2600406..2600478) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ala tRNA" gene complement(2600406..2600478) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /label="trnB-Ala gene" tRNA complement(2600484..2600560) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Pro tRNA" gene complement(2600484..2600560) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /label="trnB-Pro gene" tRNA complement(2600576..2600652) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Arg tRNA" gene complement(2600576..2600652) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /label="trnB-Arg gene" tRNA complement(2600662..2600747) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu2 tRNA" gene complement(2600662..2600747) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /label="trnB-Leu2 gene" tRNA complement(2600762..2600836) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly1 tRNA" gene complement(2600762..2600836) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /label="trnB-Gly1 gene" tRNA complement(2600842..2600928) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu1 tRNA" gene complement(2600842..2600928) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /label="trnB-Leu1 gene" tRNA complement(2600939..2601014) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Lys tRNA" gene complement(2600939..2601014) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /label="trnB-Lys gene" tRNA complement(2601052..2601127) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Thr tRNA" gene complement(2601052..2601127) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /label="trnB-Thr gene" tRNA complement(2601160..2601235) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Val tRNA" gene complement(2601160..2601235) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /label="trnB-Val gene" rRNA complement(2601256..2601373) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-5S rRNA" gene complement(2601256..2601373) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /label="rrnB-5S gene" rRNA complement(2601429..2604356) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-23S rRNA" gene complement(2601429..2604356) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /label="rrnB-23S gene" rRNA complement(2604524..2606078) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-16S rRNA" gene complement(2604524..2606078) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /label="rrnB-16S gene" Polymorphism join(2605880,2605882) /Source="geneious" /ID="SNP_BsDelta6_3178443_3178443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="T -> C" /Codon_Change /Coverage=95 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="3.5e-102" /Variant_Raw_Frequency=94 /comment="rrnB-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(2606079..2606370) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2606206..2606214 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2606212 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2606322 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2606343..2606362) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2606370) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2606372..2607338) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2606376..2606383) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2606495..2606498 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2606510 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2606513..2606532 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2606543..2606644 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswC RNA" gene 2606543..2606644 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /label="tswC gene" downshifts 2606643 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" /label="downshifts" CDS 2606744..2607322 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" /label="thiT CDS" gene 2606744..2607322 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /label="thiT gene" downshifts 2607312 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2607364..2607885) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" /label="yuaI CDS" gene complement(2607364..2607885) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /label="yuaI gene" downshifts complement(2607382) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" /label="downshifts" downshifts complement(2607454) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2607903..2609432) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" /label="floT CDS" gene complement(2607903..2609432) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /label="floT gene" CDS complement(2609453..2609977) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" /label="nfeDB CDS" gene complement(2609453..2609977) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /label="nfeDB gene" promotor_-10 complement(2610021..2610036) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2610027) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="upshifts" S_feature complement(2610029..2610116) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2610048..2610057) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2610101..2610119) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2610111 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2610115..2610134 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2610116) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2610134..2610139) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2610145..2610633 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" /label="yuaE CDS" gene 2610145..2610633 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /label="yuaE gene" downshifts 2610610 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" /label="downshifts" CDS complement(2610639..2611217) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" /label="yuaD CDS" gene complement(2610639..2611217) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /label="yuaD gene" S_feature 2610655..2611046 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2610666) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2611251..2611270) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2611260) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2611284..2611291) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2611305..2612513) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" /label="gbsB CDS" gene complement(2611305..2612513) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /label="gbsB gene" downshifts complement(2611326) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2612282..2612301) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2612294) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2612316..2612323) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2612530..2614002) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" /label="gbsA CDS" gene complement(2612530..2614002) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /label="gbsA gene" promotor_-10 complement(2614053..2614072) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2614054) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2614087..2614094) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2614114..2614120 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2614134..2614153 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2614149 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2614201..2614743 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" /label="gbsR CDS" gene 2614201..2614743 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /label="gbsR gene" downshifts 2614726 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2614820..2614827 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2614840..2614940 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2614840 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2614842..2614861 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2614941..2615486 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" /label="bslA CDS" gene 2614941..2615486 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /label="bslA gene" downshifts 2615473 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2615578..2615585 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2615599..2615618 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2615606 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2615611..2615779 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" /label="swdA RNA" gene 2615611..2615779 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /label="swdA gene" downshifts 2615760 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 2615852..2616520 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" /label="ktrA CDS" gene 2615852..2616520 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /label="ktrA gene" CDS 2616527..2617864 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" /label="ktrB CDS" gene 2616527..2617864 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /label="ktrB gene" downshifts 2617850 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2617900..2618163) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" /label="yubF CDS" gene complement(2617900..2618163) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /label="yubF gene" downshifts complement(2617918) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2618203..2618222) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2618205) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2618235..2618242) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2618272..2619120) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" /label="lytG CDS" gene complement(2618272..2619120) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /label="lytG gene" promotor_-10 complement(2619165..2619184) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2619175) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2619199..2619206) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2619281..2620816) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" /label="yubD CDS" gene complement(2619281..2620816) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /label="yubD gene" downshifts complement(2619290) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 2620474..2620574 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2620534 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2620600 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature complement(2620817..2620984) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2620973..2620992) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2620984) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2620986..2621863) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2621007..2621014) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2621226..2621235 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2621249..2621268 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2621249 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="upshifts" CDS 2621301..2621786 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" /label="cdoA CDS" gene 2621301..2621786 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /label="cdoA gene" S_feature 2621787..2622073 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2621893..2621965) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Ala1 tRNA" gene complement(2621893..2621965) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /label="trnSL-Ala1 gene" downshifts complement(2621908) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2621952) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2621976..2621995) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2621996) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2622010..2622013) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2622030 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2622073..2622903) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" /label="uppP CDS" gene complement(2622073..2622903) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /label="uppP gene" downshifts complement(2622084) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2622904..2622995) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2622996..2624162) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" /label="yubA CDS" gene complement(2622996..2624162) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /label="yubA gene" promotor_-35 2624158..2624162 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2624170..2624184 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2624186..2624205) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2624186 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2624205) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2624219..2624226) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2624284..2624291 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2624297 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2624302..2624321 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2624344..2625330 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA*" /label="iolU CDS" gene 2624344..2625330 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /label="iolU gene" downshifts 2625301 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2625371..2626645) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /EC_number="5.3.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose isomerase" /protein_id="NP_390996.1" /db_xref="EnsemblGenomes-Gn:BSU31180" /db_xref="EnsemblGenomes-Tr:CAB15096" /db_xref="GOA:O05264" /db_xref="InterPro:IPR009308" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG12387" /db_xref="UniProtKB/Swiss-Prot:O05264" /translation="MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIE GFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNRE AVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRH CIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQ HNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSML LYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRV AAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCE QMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV*" /label="rhaA CDS" gene complement(2625371..2626645) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /label="rhaA gene" downshifts complement(2625384) /Source="Nicolas_upshifts" /id="D1615" /incds=0 /nref=3 /ntot=29 /MaxReadThrough="0.802" /MaxDrop="4.45322" /score="14.0829844" /energy="-12.6" /TU="NA" /idTUdmin="U2421" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2626671..2626985) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /EC_number="5.1.3.32" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15576793, 15876375, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576793, 15876375, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose mutarotase" /protein_id="NP_390997.1" /db_xref="EnsemblGenomes-Gn:BSU31190" /db_xref="EnsemblGenomes-Tr:CAB15097" /db_xref="GOA:O05263" /db_xref="InterPro:IPR008000" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR013448" /db_xref="SubtiList:BG12386" /db_xref="UniProtKB/Swiss-Prot:O05263" /translation="MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIF LDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFY LD*" /label="rhaM CDS" gene complement(2626671..2626985) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /label="rhaM gene" CDS complement(2627003..2628460) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /EC_number="2.7.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16674975, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16674975, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnulokinase" /protein_id="NP_390998.1" /db_xref="EnsemblGenomes-Gn:BSU31200" /db_xref="EnsemblGenomes-Tr:CAB15098" /db_xref="GOA:O05262" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR013449" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG12385" /db_xref="UniProtKB/Swiss-Prot:O05262" /translation="MIYTAIDVGASSGRIMVGELNEGKLDIQEIHRFANGFSQRDGHC LWDIDHLLKQILQGLQKVKTLGYEHCTVGIDTWAVDYVLLDEKGDRLREAISYRDRRT DHTIDKLEHTLSKAAIYQKTGIQFQPFNTIYQLFEEDRELLKKTDKIMMIPDYLGYCL TGKAVTEITNVSTTQLLNVSTGNLDPELLEAVSVLEQQFAPLTEPGCELGKLRNEWFP DYDLPACKVMTVATHDTASAVIAAPGVNDGWAYISSGTWSLIGVENKTPIITDLALEN NYTNERGANNTIRFLKNIIGMWVIQEVKQQLQADYSFQQLAEEAKKTEPFQQFINLND KRFLNPENMIKEIQHYCRQTRQKIPRTAGELACCIYSNLAIIYAIAIKELETITEKPI EQFHIIGGGARNDFLNQLTADMSGKAVYAGPIEATATGNLLMQMIAAKEVKDIKEARQ VVRNSFPIKVFTPKDIDRSTIIQSFQQTVLKALSK*" /label="rhaB CDS" gene complement(2627003..2628460) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /label="rhaB gene" CDS complement(2628465..2629241) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11496004, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11496004, 26712933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the rhamnose operon(RhaR / l-rhamnulose-1-phosphate)" /protein_id="NP_390999.1" /db_xref="EnsemblGenomes-Gn:BSU31210" /db_xref="EnsemblGenomes-Tr:CAB15099" /db_xref="GOA:O05261" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12384" /db_xref="UniProtKB/Swiss-Prot:O05261" /translation="MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLE KEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDAST TAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSL ETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSH IASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG*" /label="rhaR CDS" gene complement(2628465..2629241) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /label="rhaR gene" misc_feature complement(2629275..2629294) /Source="Nicolas_upshift_promotors" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2629291) /Source="Nicolas_upshifts" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2629298..2631367) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /EC_number="1.1.1.-" /EC_number="4.1.2.19" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24391637, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24391637, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase" /protein_id="NP_391000.1" /db_xref="EnsemblGenomes-Gn:BSU31220" /db_xref="EnsemblGenomes-Tr:CAB15100" /db_xref="GOA:P40747" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR013454" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG10947" /db_xref="UniProtKB/Swiss-Prot:P40747" /translation="MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSM KTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYL SHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVW VPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQY INDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEF VNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQ AYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATAL GQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAE GGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGID IVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGS KNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWR EERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGG VPAAFTR*" /label="rhaE CDS" gene complement(2629298..2631367) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /label="rhaE gene" promotor_-10 complement(2631400..2631419) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2631412) /Source="Nicolas_upshifts" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2631433..2631439) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2631505..2633493) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391001.1" /db_xref="EnsemblGenomes-Gn:BSU31230" /db_xref="EnsemblGenomes-Tr:CAB15101" /db_xref="GOA:P39217" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10862" /db_xref="UniProtKB/Swiss-Prot:P39217" /translation="MGKFIQWIKQPSISKPLIAAFLAVLILPVGVLAYFSYQSAWNAL DRELISSAKGNVEELNSTLQNKLEDKVKAIDYYSETVDKDILLGKNKTLLKEKFKQYT TLNDDVGAIYAASEDKKLYKYPDSGVPKGFDPTGRDWYKQAVAEKGQAVFSEPYTDEA TGDIVVTISKQLKDGSGVIALDLNLDEVLTASKRIKIGKEGFAFITTGNKKYIAHPTI KPGTTGSGDWTNQVYSKKEGSFEYTFEGKEKKMAFTTNKLTGWKIAGTYFVSELQDAS SPVLNTAVIILCVSIVIGGILILYIIRAITKPLRKLVSTSAKISSGDLTEVIDIHSKN EFGQLGESFNEMSASLRSVIGVIQTSVENVASSSEELTASAAQTSKATEHITLAIEQF SDGNEAQSEKLETSSNHLSQMNEGISKVAQASSTITKSSIQSSEAAGSGEKLVEHTVG QMKTIDQSVQKAEAVVKGLETKSQDITSILNVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIQEIVREISTSLSMFQSVNHEVKEGLQITDQ TAESFKQIYEMTTQISGELQNLNATVEQLSAGSQEVSSAVEDISAVAKESSAGIQDIA ASAEEQLASMEEISSSAETLANMAEELQDITKKFKIES*" /label="tlpB CDS" gene complement(2631505..2633493) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /label="tlpB gene" downshifts complement(2631524) /Source="Nicolas_upshifts" /id="D1616" /incds=0 /nref=108 /ntot=174 /MaxReadThrough="3.32915" /MaxDrop="6.75141" /score="18.7221191" /energy="-8.3" /TU="NA" /idTUdmin="U2423" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2633497..2633504 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2633514..2633532) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2633520..2633539 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2633527) /Source="Nicolas_upshifts" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="upshifts" upshifts 2633536 /Source="Nicolas_upshifts" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2633546..2633553) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2633602 /Source="Nicolas_upshifts" /id="D1617" /incds=0 /nref=4 /ntot=11 /MaxReadThrough="1.04089" /MaxDrop="4.2056" /score="13.4355481" /energy="-10.7" /TU="NA" /idTUdmin="U2424" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2633607..2635592) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 9721285, 12011078" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 9721285, 12011078; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391002.2" /db_xref="EnsemblGenomes-Gn:BSU31240" /db_xref="EnsemblGenomes-Tr:CAB15102" /db_xref="GOA:P39214" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10861" /db_xref="UniProtKB/Swiss-Prot:P39214" /translation="MKKILQLIKQRSITRKLLVSFLSILIIPVVILAIFAYQSASSSL DRQMMGSALENVQQLNEIINTSIGEKENSADYFSEWLTKEKYNAKSNASIAEKFSQYI SINKDVESIYTSDTKGHFTRYPDLPMPSGYNPVERDWYKKAVANKGKVVITDPYKTAS TNTMVVTIAQQTKDGSGVIAINMTIENLLKTTKKVNIGTQGYAFIMTKDKKVVAHPNE QSGTELKGDWLDKMLSADKGDFQYTMDGDKKKMAFDTNKLTGWKIGGTMYLDEIHEAA QPVLHLALIVLAAAIIIGIIVMTLIIRSITTPLKQLVGSSKRISEGDLTETIDIRSKD ELGELGKSFNNMASSLRSLIHAIQDSVDNVAASSEELTASAAQTSKATEHITLAIEQF SNGNEKQNENIETAAEHIYQMNDGLTNMAQASEVITDSSVQSTEIASEGGKLVHQTVG QMNVIDKSVKEAEQVVRGLETKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIIEIVKEINTSLGMFQSVNQEVQTGLDITDK TEMSFKRISEMTNQIAGELQNMSATVQQLSASSEEVSGASEHIASISKESSAHIQDIA ASAEEQLASMEEISSSAETLSSMAEELRDMTKRFKIE*" /label="mcpA CDS" gene complement(2633607..2635592) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /label="mcpA gene" downshifts complement(2633612) /Source="Nicolas_upshifts" /id="D1618" /incds=0 /nref=196 /ntot=232 /MaxReadThrough="3.11319" /MaxDrop="7.54297" /score="40.6270404" /energy="-13.6" /TU="U2425" /idTUdmin="U2425" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2635613..2635631) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2635628) /Source="Nicolas_upshifts" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2635630..2635717) /Source="Nicolas_S_feature" /locus_tag="new_3208192_3208279_c" /HighExp="GM 150, T0.0H, T-1.40H, T-0.40H, MG 150, T-5.40H, T-3.40H, T-1.10H, T-2.40H, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1190" promotor_-35 complement(2635645..2635652) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2635718..2637706) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871, 26522943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871, 26522943; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (membrane curvature dependent localisation)" /protein_id="NP_391003.1" /db_xref="EnsemblGenomes-Gn:BSU31250" /db_xref="EnsemblGenomes-Tr:CAB15103" /db_xref="GOA:P39216" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10860" /db_xref="UniProtKB/Swiss-Prot:P39216" /translation="MKKTLTTIRRSSIARRLIISFLLILIVPITALSVSAYQSAVASL DVQMTQSAKENVQILDHIIDDKISTTEKSLAYFSDWATAEKFQDKKKTELKQEFKQFI QMNDNVAAVFSSGKDGDFTRYPYADMPSDFNALERDWYKEAMANKGKTIVTEPYESIS SGKMVVTIARQTVDGSGVVAIDMKIDDLVTTAKGINIGKEGYAFILSQNKKVIAYSGE KAGTELKGDWVDKLYKDKSGDFEYTYKGKKKKMAFATSQTTGWKISGTMYANEIHDAA SRVLIMASIVLAIAIGAGMTAIYFVIRSITKPLRRIVASAEKISEGDLTETIEINSKD ELGVLSESFNHMAHSLRSLIHGIKDSVEHVASSSEELTASADQTSRATEHITMAIEQF SNGSESQSEKIETTTEQINEMNDGLAELARAAAVITETSADSTEVSSKGETLVQKTAG QMNTIDHSVKAAEQVVKGLEIKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIESLISEIVKEIHTSLNVLQSVNKEVETGLVMTDE TKQSFKHISQMTNQIASELQNMNATVEELSAGAQEISAASNDITAISKESSDGIQDIA ASAEEQLASMEEISSSALTLERMSEELRDLTKQFKVDK*" /label="tlpA CDS" gene complement(2635718..2637706) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /label="tlpA gene" promotor_-10 complement(2637731..2637749) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-10" upshifts complement(2637746) /Source="Nicolas_upshifts" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="upshifts" promotor_-35 complement(2637763..2637770) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-35" CDS complement(2637883..2639871) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391004.2" /db_xref="EnsemblGenomes-Gn:BSU31260" /db_xref="EnsemblGenomes-Tr:CAB15104" /db_xref="GOA:P39215" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10859" /db_xref="UniProtKB/Swiss-Prot:P39215" /translation="MKTFINWLKKPSISKKLIVSFIAILIIPILILEFSSYRSASGKL DQEIMGNAKNSVDTFNTTVTNDLGEKAKAVTFFSESLKRSAFKGKSNQEEIKAKFSQY VSINQGVARIYGGADNGTYVQAPKEKLPEGYDPRQRPWYQDAMKAGGEIVVTDPYVAA SDGSMVITIAQELKDGSGVVAMDITIDKLLEQMKQIKVGKEGYAFIATKNKTYVAHKN HKAGEKLSGDWVAKMYANDSGELQYTLNNEDKKMTYTTNELTGWKIAGTMYMDEIKDA SKSVLTTGMIVLIASIVAGGILILFIVRSITKPLKRLVQSSKTISRGDLTETIEIHSK DELGELGESFNEMGQSLRSLISAIQDSVNNVAASSEQLTASAGQTSKATEHITMAIEQ FSNGNEEQSEKVESSSHQLNLMNEGLQQVSQTSSDITKASIQSTEIAGTGEKFVQQTV GQMNSINQSVQQAEAVVKGLEGKSKDITSILRVINGIADQTNLLALNAAIEAARAGES GRGFSVVAEEVRKLAVQSADSAKEIEKLIQEIVAEIDTSLHMFKEVNQEVQSGLVVTD NTKESFQSIFSMTNEIAGKLQTMNSTVEQLSDRSQHVSAAVSGIADVSKESSASIQDI AASAEEQLASMEEISSSATTLAQMAEELRDLTKQFKIE*" /label="mcpB CDS" gene complement(2637883..2639871) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /label="mcpB gene" downshifts complement(2637902) /Source="Nicolas_upshifts" /id="D1619" /incds=0 /nref=136 /ntot=224 /MaxReadThrough="3.76161" /MaxDrop="7.09773" /score="30.8363643" /energy="-10.7" /TU="U2427" /idTUdmin="U2427" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2639892..2639910) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2639913) /Source="Nicolas_upshifts" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2639923..2639930) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2639973..2639982 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2639996..2640015 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2639999 /Source="Nicolas_upshifts" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="upshifts" CDS 2640029..2640766 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /EC_number="2.3.2.13" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9692191, 16267299, 16751597, 16936016, 18249137, 26322858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9692191, 16267299, 16751597, 16936016, 18249137, 26322858; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein-glutamine gamma-glutamyltransferase (transglutaminase)" /protein_id="NP_391005.1" /db_xref="EnsemblGenomes-Gn:BSU31270" /db_xref="EnsemblGenomes-Tr:CAB15105" /db_xref="GOA:P40746" /db_xref="InterPro:IPR020916" /db_xref="PDB:4P8I" /db_xref="PDB:4PA5" /db_xref="SubtiList:BG10946" /db_xref="UniProtKB/Swiss-Prot:P40746" /translation="MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAE LMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAI RDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTET GHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFR KKGALQSAYLLSQATRLDVPSLFRIVR*" /label="tgl CDS" gene 2640029..2640766 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /label="tgl gene" promotor_-10 complement(2640054..2640073) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-10" upshifts complement(2640062) /Source="Nicolas_upshifts" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="upshifts" promotor_-35 complement(2640089..2640093) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-35" S_feature 2640767..2643587 /Source="Nicolas_S_feature" /locus_tag="new_3213329_3216149" /HighExp="S6, S8, S7, BT, S5, C30, B36, Pyr, BC, C90" /AntisenseName="yugT" /AntisenseCor="0.63350809138227804" /AntisenseRegPval="-30.9" /CDS_PredictionProba="0.61985900000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1191" CDS complement(2640780..2641034) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097776.1" /db_xref="EnsemblGenomes-Gn:BSU31279" /db_xref="EnsemblGenomes-Tr:CAX52682" /db_xref="UniProtKB/Swiss-Prot:C0H3Q3" /translation="MNILQYSYKKRGKIEFVFEGWPHSKVTMVPIKGYYFVRFIKWSS QDPIVTRNDLEKMEWAANQYFGTAPFYRKRKAFETPSSGK*" /label="yuzH CDS" gene complement(2640780..2641034) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /label="yuzH gene" downshifts complement(2640806) /Source="Nicolas_upshifts" /id="D1620" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="2.39206" /MaxDrop="2.92958" /score="-2.51333596" /energy="-14.7" /TU="NA" /idTUdmin="U2430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2641035..2641291) /Source="Nicolas_S_feature" /locus_tag="new_3213597_3213853_c" /HighExp="Etha, Sw, Salt, Gly, BC, M9-stat, Lbstat, Heat, LPhT, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37980700000000001" /TUshortSig="SigB" /TUshortPSig="0.969" /TUlongSig="NA" /TUlongPSig="NA" /label="S1192" CDS complement(2641292..2641690) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391006.2" /db_xref="EnsemblGenomes-Gn:BSU31280" /db_xref="EnsemblGenomes-Tr:CAB15106" /db_xref="InterPro:IPR001602" /db_xref="InterPro:IPR035917" /db_xref="SubtiList:BG12373" /db_xref="UniProtKB/Swiss-Prot:O05243" /translation="MLKTLQIKTTKRDEMIDITREVEAFLQETGITSGAALIYCPHTT AGITINENADPDVKKDMLRRFDEVYPWEHELDRHMEGNTAAHMKSSTVGASQHVIVEN GRLILGTWQGIYFCEFDGPRTRTCYIKMMG*" /label="yugU CDS" gene complement(2641292..2641690) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /label="yugU gene" CDS complement(2641650..2641784) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514000.1" /translation="MFYRVYESGLTGKKRTQNELSDESGQTKGETNAENTANQNNQTR *" /label="hypothetical protein CDS" gene complement(2641650..2641784) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /label="gene" promotor_-10 complement(2641733..2641752) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2641740) /Source="Nicolas_upshifts" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2641767..2641773) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2641810..2643474) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1761534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-1,6-glucosidase" /protein_id="NP_391007.2" /db_xref="EnsemblGenomes-Gn:BSU31290" /db_xref="EnsemblGenomes-Tr:CAB15118" /db_xref="GOA:O05242" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG12372" /db_xref="UniProtKB/Swiss-Prot:O05242" /translation="MKKAWWKEAVVYQIYPRSFKDSNGDGIGDIQGIRTKLSYIKELG ADVIWICPLYDSPNADNGYDIRDYQNILSEFGTMEDFDELLGDIHDLDMKLIMDLVVN HTSDEHPWFIESRSSIHSEKRDWYIWKDGKNGKTPNNWESIFGGPAWEYDQKTSQYYL HLFDKKQPDLNWENEKVRNAVYDMINWWLDKGIDGFRVDAITHIKKKEGFPDMPNPKG LDYVPSFPYHMNADGIMDLLTELKENTFSRYPIMTVGEANGVAAKEAADWAGEKNGIF SMIFQFEHLGLWDVEINESIDIVAFKRILTDWQDSLEGIGWNALFMENHDQPRSVSVW GDDGVYLKESAKALSAVYFLMKGTPFIYQGQELGMTNVAFPSIEDYDDVALKRLYETK TAKGTSHEDVMKIVWKKGRDNSRTPMQWNAGPYAGFSEAKPWIGINENYKWLNAEAQK NDKTSVYHFYKSLIKLRQTYDVFINGTYELILPEDQQIFAYLRKNESHTALIAANLTG TPALFRHSGLPLSSDALVLSNIETEPHKHMTSVLLKPYEARIYLWC*" /label="yugT CDS" gene complement(2641810..2643474) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /label="yugT gene" downshifts complement(2641826) /Source="Nicolas_upshifts" /id="D1621" /incds=0 /nref=13 /ntot=38 /MaxReadThrough="1.79723" /MaxDrop="4.64379" /score="19.4176812" /energy="-6.5" /TU="NA" /idTUdmin="U2432" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2642782..2642801) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2642787) /Source="Nicolas_upshifts" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2642815..2642822) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2643499..2643517) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2643516) /Source="Nicolas_upshifts" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2643533..2643538) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2643601..2644890) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_391008.2" /db_xref="EnsemblGenomes-Gn:BSU31300" /db_xref="EnsemblGenomes-Tr:CAB15119" /db_xref="GOA:O05241" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12371" /db_xref="UniProtKB/Swiss-Prot:O05241" /translation="MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSR ALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIV TFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSA SFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVARE IMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLG QPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEI VGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQ KMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF*" /label="yugS CDS" gene complement(2643601..2644890) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /label="yugS gene" downshifts complement(2643610) /Source="Nicolas_upshifts" /id="D1622" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.89237" /MaxDrop="3.67001" /score="3.60520478" /energy="-7.6" /TU="NA" /idTUdmin="U2434" /TUdmin=13 /isTUend="TRUE" /label="downshifts" promotor_-35 2644419..2644425 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2644439..2644457 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2644445 /Source="Nicolas_upshifts" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="upshifts" S_feature 2644449..2645101 /Source="Nicolas_S_feature" /locus_tag="new_3217011_3217663" /HighExp="Etha, Sw, Gly, Salt, BC, B60, Heat, S8, B36, HiTm" /AntisenseName="yugS" /AntisenseCor="0.12310225183111501" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1193" CDS complement(2644934..2645611) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16704729, 16850406, 24383880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent protease/peptidase" /protein_id="NP_391009.1" /db_xref="EnsemblGenomes-Gn:BSU31310" /db_xref="EnsemblGenomes-Tr:CAB15120" /db_xref="GOA:O05248" /db_xref="InterPro:IPR007395" /db_xref="SubtiList:BG12370" /db_xref="UniProtKB/Swiss-Prot:O05248" /translation="MLFIFLTIAALGLSFWAQFKVKSNFEKYSKVEASSGRTGAETAR RILDINGLYDVPVEPVRGTLTDHYDPTRRVVRLSEPVYYGRSISAISVASHEVGHALQ HQESYGALVLRHKIFPVVNFASGVAPLLFLGGMLLGSLNLIGLGIILFSAAVFFQLIT LPVEFNASSRAKQIIVSEGFIRNNEENGVNKVLSAAALTYVAAALVSLFELLRFVMIF LNGRDEN*" /label="yugP CDS" gene complement(2644934..2645611) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /label="yugP gene" downshifts complement(2644944) /Source="Nicolas_upshifts" /id="D1623" /incds=0 /nref=153 /ntot=249 /MaxReadThrough="3.51629" /MaxDrop="4.854" /score="33.0420688" /energy="-13" /TU="U2434,U2435" /idTUdmin="U2435" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" S_feature 2645286..2645962 /Source="Nicolas_S_feature" /locus_tag="new_3217848_3218524" /HighExp="Sw, S8, Salt, BC, S7, Etha, Gly, B36, B60, LPhT" /AntisenseName="yuzI" /AntisenseCor="0.20035821815170399" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1194" promotor_-10 complement(2645646..2645665) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2645653..2645916) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16704729; Product type f : factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097777.1" /db_xref="EnsemblGenomes-Gn:BSU31319" /db_xref="EnsemblGenomes-Tr:CAX52683" /db_xref="GOA:C0H3Q4" /db_xref="UniProtKB/Swiss-Prot:C0H3Q4" /translation="MTIFQRTIVVLIGTQLAASAVILFIFDLNSYNHFSGSFSWLHFL KELAGSFAFYLFSAGLFFLLIGLCAPSRKKKRISVHEKENSLK*" /label="yuzI CDS" gene complement(2645653..2645916) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /label="yuzI gene" upshifts complement(2645667) /Source="Nicolas_upshifts" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2645679..2645686) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2645928..2645946) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2645942) /Source="Nicolas_upshifts" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2645962..2645967) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2645963..2646295 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15731457, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15731457, 23737939, 25297828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="atypical membrane-integrating regulator of biofilm formation (Mistic protein)" /protein_id="YP_003097778.1" /db_xref="EnsemblGenomes-Gn:BSU31321" /db_xref="EnsemblGenomes-Tr:CAX52684" /db_xref="GOA:Q5BU39" /db_xref="InterPro:IPR021078" /db_xref="PDB:1YGM" /db_xref="UniProtKB/Swiss-Prot:Q5BU39" /translation="MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRM NEGLDAFIQLYNESEIDEPLIQLDDDTAELMKQARDMYGQEKLNEKLNTIIKQILSIS VSEEGEKE*" /label="mstX CDS" gene 2645963..2646295 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /label="mstX gene" promotor_-35 2645980..2645986 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2646001..2646018 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2646012 /Source="Nicolas_upshifts" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="upshifts" CDS 2646292..2647278 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16704729, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16704729, 23737939, 25297828; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium channel protein involved in biofilm formation" /protein_id="NP_391010.3" /db_xref="EnsemblGenomes-Gn:BSU31322" /db_xref="EnsemblGenomes-Tr:CAB15121" /db_xref="GOA:Q795M8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR013099" /db_xref="InterPro:IPR028325" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12369" /db_xref="UniProtKB/Swiss-Prot:Q795M8" /translation="MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTS VFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQH RYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHF IRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVE ILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLA VPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI*" /label="kbfO CDS" gene 2646292..2647278 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /label="kbfO gene" downshifts complement(2647253) /Source="Nicolas_upshifts" /id="D1624" /incds=0 /nref=44 /ntot=128 /MaxReadThrough="0.617940000000001" /MaxDrop="4.76695" /score="21.5904825" /energy="-11.3" /TU="NA" /idTUdmin="U2437" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2647275..2647679) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391011.1" /db_xref="EnsemblGenomes-Gn:BSU31330" /db_xref="EnsemblGenomes-Tr:CAB15122" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG12368" /db_xref="UniProtKB/Swiss-Prot:O05246" /translation="MIPIPSAIDGQSFLLQELEQVMKPLGYVINGGWEYDHGYFDYKI DDRDGYLFLRIPVNAVQGSLDERGAAVRIGTPFMLRQVFQADVDDHAEGGPFQSLFNQ FSEPERRDAEIDPAFLDIGASLVKELEDVLLH*" /label="yugN CDS" gene complement(2647275..2647679) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /label="yugN gene" S_feature complement(2647680..2647738) /Source="Nicolas_S_feature" /locus_tag="new_3220242_3220300_c" /HighExp="M0t90, M40t90, S6, S8, S7, T0.30H, Lbstat, M9-stat, T1.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-, SigA" /TUshortPSig="0.686, 0.141, 0.984" /TUlongSig="SigA" /TUlongPSig="0.988" /label="S1195" CDS complement(2647739..2648110) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391012.1" /db_xref="EnsemblGenomes-Gn:BSU31340" /db_xref="EnsemblGenomes-Tr:CAB15123" /db_xref="GOA:O05245" /db_xref="SubtiList:BG12367" /db_xref="UniProtKB/Swiss-Prot:O05245" /translation="MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHF FIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAV YFLIECAFFPVGRAKETTISM*" /label="yugM CDS" gene complement(2647739..2648110) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /label="yugM gene" CDS complement(2648169..2649521) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" /label="pgi CDS" gene complement(2648169..2649521) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /label="pgi gene" downshifts complement(2648180) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2648336..2648354) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2648353) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2648370..2648375) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2649494) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2649497..2649508) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2649553..2649572) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2649559) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2649561..2649632) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2649587..2649590) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2649633..2650805) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" /label="bdhK CDS" gene complement(2649633..2650805) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /label="bdhK gene" S_feature 2649968..2650889 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2650838..2650857) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2650851) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="upshifts" promotor_-35 complement(2650874..2650877) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2650909..2652072) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" /label="bdhJ CDS" gene complement(2650909..2652072) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /label="bdhJ gene" downshifts complement(2650924) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2652087..2652106) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2652105) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="upshifts" S_feature complement(2652107..2652262) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2652121..2652128) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2652158..2652164 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2652179..2652197 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2652189 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2652190..2652248 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2652235..2652241 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2652237..2652248) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2652250 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2652255..2652266 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2652262..2652268) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2652262) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2652264..2652575) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2652302..2652538 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" /label="yuzA CDS" gene 2652302..2652538 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /label="yuzA gene" downshifts 2652498 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2652564 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2652616..2653008) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" /label="yugI CDS" gene complement(2652616..2653008) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /label="yugI gene" downshifts complement(2652620) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2653050..2653069) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2653057) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="upshifts" S_feature complement(2653059..2653209) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2653085..2653089) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2653112..2653118 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2653125..2654109 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2653125 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2653133..2653151 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2653210..2654370) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" /label="yugH CDS" gene complement(2653210..2654370) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /label="yugH gene" promotor_-35 2654262..2654268 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2654280 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2654282..2654286 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2654371..2654871) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" /label="yugG CDS" gene complement(2654371..2654871) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /label="yugG gene" promotor_-10 complement(2654901..2654920) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2654907..2654913 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2654922) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="upshifts" promotor_-10 2654928..2654939 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2654928 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2654931..2654938) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2654940..2655018 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2655019..2655840 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" /label="yugF CDS" gene 2655019..2655840 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /label="yugF gene" downshifts 2655820 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2655867) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(2655869..2656129) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" /label="yugE CDS" gene complement(2655869..2656129) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /label="yugE gene" promotor_-35 2656119..2656122 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2656137..2656156 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2656149 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="upshifts" S_feature 2656150..2656215 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2656155..2656174) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2656160) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2656186..2656192) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2656216..2657379 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" /label="patB CDS" gene 2656216..2657379 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /label="patB gene" promotor_-35 2657442..2657448 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2657460..2657479 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2657470 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2657505..2658791 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" /label="kinB CDS" gene 2657505..2658791 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /label="kinB gene" S_feature complement(2658507..2659249) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2658786..2658793 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2658807..2658826 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2658808 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2658837..2659223 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" /label="kapB CDS" gene 2658837..2659223 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /label="kapB gene" downshifts 2659205 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2659250..2659867) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" /label="kapD CDS" gene complement(2659250..2659867) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /label="kapD gene" promotor_-10 complement(2659902..2659920) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2659919) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2659921..2662009) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(2659935..2659940) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2659983..2659986 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 2660001..2660020 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 2660012 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="upshifts" CDS 2660078..2661256 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" /label="yuxJ CDS" gene 2660078..2661256 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /label="yuxJ gene" promotor_-35 2661294..2661300 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2661312..2661331 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2661317 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="upshifts" CDS 2661349..2663223 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" /label="pbpD CDS" gene 2661349..2663223 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /label="pbpD gene" promotor_-10 complement(2661989..2662008) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2662009) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2662022..2662031) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2663244..2663657 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" /label="yuxK CDS" gene 2663244..2663657 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /label="yuxK gene" downshifts 2663649 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2663860..2664417) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" /label="yufK CDS" gene complement(2663860..2664417) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /label="yufK gene" misc_feature 2663881..2663900 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2663891 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2663901) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 2663913..2664594 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(2664443..2664462) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2664451) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2664478..2664482) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2664595..2666196 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" /label="maeL CDS" gene 2664595..2666196 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /label="maeL gene" CDS 2666189..2666896 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" /label="maeM CDS" gene 2666189..2666896 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /label="maeM gene" downshifts 2666881 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" /label="downshifts" promotor_-35 2667060..2667067 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2667078..2667367 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 2667078 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2667082..2667101 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2667368..2668447 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" /label="nupN CDS" gene 2667368..2668447 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /label="nupN gene" CDS 2668523..2670055 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" /label="nupO CDS" gene 2668523..2670055 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /label="nupO gene" CDS 2670048..2671094 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" /label="nupP CDS" gene 2670048..2671094 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /label="nupP gene" CDS 2671095..2672054 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" /label="nupQ CDS" gene 2671095..2672054 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /label="nupQ gene" S_feature 2672055..2672176 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 2672149..2672152 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2672167..2672186 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2672178 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="upshifts" CDS 2672208..2673554 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" /label="maeN CDS" gene 2672208..2673554 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /label="maeN gene" downshifts 2673537 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(2673590..2673805) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" /label="yufS CDS" gene complement(2673590..2673805) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /label="yufS gene" promotor_-35 2673745..2673751 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2673765..2673776 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2673769 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2673816..2673834) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2673823) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2673848..2673855 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2673850..2673855) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2673870..2673965 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 2673870..2673889 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2673870 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2673928..2673932 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2673948..2673967 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2673967..2674116 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 2673967 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2674036..2676441 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" /label="mrpA CDS" gene 2674036..2676441 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /label="mrpA gene" CDS 2676434..2676865 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" /label="mrpB CDS" gene 2676434..2676865 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /label="mrpB gene" CDS 2676865..2677206 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" /label="mrpC CDS" gene 2676865..2677206 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /label="mrpC gene" promotor_no_box 2677097..2677197 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2677157 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2677199..2678680 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" /label="mrpD CDS" gene 2677199..2678680 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /label="mrpD gene" S_feature complement(2677932..2679800) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 2678686..2679162 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" /label="mrpE CDS" gene 2678686..2679162 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /label="mrpE gene" CDS 2679162..2679446 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" /label="mrpF CDS" gene 2679162..2679446 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /label="mrpF gene" CDS 2679430..2679804 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" /label="mrpG CDS" gene 2679430..2679804 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /label="mrpG gene" downshifts 2679775 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2679843..2680223) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" /label="yuxO CDS" gene complement(2679843..2680223) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /label="yuxO gene" downshifts complement(2679845) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" /label="downshifts" CDS complement(2680242..2680886) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" /label="comA CDS" gene complement(2680242..2680886) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /label="comA gene" S_feature complement(2680887..2680966) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(2680967..2683276) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" /label="comP CDS" gene complement(2680967..2683276) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /label="comP gene" promotor_-35 2681961..2681968 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2681982..2682001 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2681997 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 2682870..2683841 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 2682870 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2682882..2682898 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2683291..2683458) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" /label="comX CDS" gene complement(2683291..2683458) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /label="comX gene" CDS complement(2683446..2684344) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKS**RNAY*VIQRGIQDARP" /label="comQ CDS" gene complement(2683446..2684344) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /label="comQ gene" S_feature complement(2684345..2684458) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(2684452..2684471) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2684458) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2684485..2684491) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2684529..2684669) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" /label="degQ CDS" gene complement(2684529..2684669) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /label="degQ gene" downshifts complement(2684558) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2684670..2684756) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(2684740..2684759) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2684756) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2684773..2684779) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2684856..2684874) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2684866) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2684889..2684895) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2684891..2685016 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" /label="hypothetical protein CDS" gene 2684891..2685016 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /label="gene" S_feature complement(2685044..2685473) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 2685069..2685074 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2685086) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 2685089..2685107 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2685091 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="upshifts" CDS 2685130..2685498 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" /label="cotIC CDS" gene 2685130..2685498 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /label="cotIC gene" CDS complement(2685474..2686703) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" /label="pdeH CDS" gene complement(2685474..2686703) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /label="pdeH gene" S_feature 2685499..2686812 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(2686738..2686757) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2686757) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="upshifts" downshifts 2686770 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2686772..2686779) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2686840..2688312) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" /label="pncB CDS" gene complement(2686840..2688312) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /label="pncB gene" downshifts complement(2686850) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" misc_feature 2688193..2688197 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2688200 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2688310 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS complement(2688328..2688879) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" /label="pncA CDS" gene complement(2688328..2688879) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /label="pncA gene" promotor_-10 complement(2688901..2688920) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2688914) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2688933..2688940) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2688976..2689374) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" /label="yueI CDS" gene complement(2688976..2689374) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /label="yueI gene" S_feature complement(2689375..2689445) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(2689446..2689694) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" /label="yueH CDS" gene complement(2689446..2689694) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /label="yueH gene" promotor_-10 complement(2689717..2689736) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2689728) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2689752..2689755) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2689767..2689988) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" /label="yueG CDS" gene complement(2689767..2689988) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /label="yueG gene" downshifts complement(2689794) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2689982 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2690006..2690025) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2690012) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2690038..2690047) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2690048..2691157) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" /label="yueF CDS" gene complement(2690048..2691157) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /label="yueF gene" promotor_-35 2690809..2690816 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2690831..2690850 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2690840..2691234 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 2690840 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2691205..2691224) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(2691221) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="upshifts" S_feature complement(2691223..2691663) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 2691226..2691228 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2691236 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2691238..2691243) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 2691244..2691263 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2691272..2691661 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" /label="yuzE CDS" gene 2691272..2691661 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /label="yuzE gene" CDS complement(2691702..2691938) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" /label="yuzF CDS" gene complement(2691702..2691938) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /label="yuzF gene" downshifts complement(2691708) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2691958..2691977) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2691972) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2691974..2692114) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(2691991..2692000) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2692115..2692645) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" /label="yueE CDS" gene complement(2692115..2692645) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /label="yueE gene" promotor_-10 complement(2692665..2692684) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(2692676) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="upshifts" S_feature complement(2692678..2692764) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(2692696..2692704) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(2692759..2692778) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2692766) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2692792..2692801) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2692843..2693574) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" /label="bznD CDS" gene complement(2692843..2693574) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /label="bznD gene" downshifts complement(2692873) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2693589..2693608) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2693600) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2693623..2693630) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2693637..2694092) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" /label="yueC CDS" gene complement(2693637..2694092) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /label="yueC gene" promotor_-35 2694045..2694051 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2694066..2694084 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2694074..2696441 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 2694074 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2694124..2697354) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" /label="yueB CDS" gene complement(2694124..2697354) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /label="yueB gene" CDS complement(2697351..2701838) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" /label="yukAB CDS" gene complement(2697351..2701838) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /label="yukAB gene" promotor_-35 2701113..2701119 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2701134..2701152 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2701140..2702102 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 2701140 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2701899..2703254) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" /label="yukC CDS" gene complement(2701899..2703254) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /label="yukC gene" downshifts complement(2701920) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" /label="downshifts" CDS complement(2703269..2703508) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" /label="yukD CDS" gene complement(2703269..2703508) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /label="yukD gene" CDS complement(2703578..2703871) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" /label="yukE CDS" gene complement(2703578..2703871) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /label="yukE gene" downshifts complement(2703588) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" /label="downshifts" downshifts 2703865 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" S_feature complement(2703872..2703950) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 2703913..2703920 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2703930..2703949) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2703931 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2703935..2703952 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2703950) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2703964..2703971) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2704009..2704014 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2704029..2704048 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2704041..2704147 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 2704041 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2704216..2704222 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2704236..2704255 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2704239 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2704344..2704347 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 2704356 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="upshifts" promotor_-10 complement(2704359..2704378) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2704363..2704382 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(2704381) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2704392..2705660 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" /label="adeR CDS" gene 2704392..2705660 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /label="adeR gene" promotor_-35 complement(2704393..2704400) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2705720..2705739 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2705725 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2705762..2706898 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" /label="ald CDS" gene 2705762..2706898 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /label="ald gene" downshifts 2706898 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" /label="downshifts" promotor_-35 2706947..2706955 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2706965 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2706967..2706985 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2707010..2707687 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" /label="yukJ CDS" gene 2707010..2707687 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /label="yukJ gene" downshifts 2707671 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2707731..2707940) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" /label="mbtH CDS" gene complement(2707731..2707940) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /label="mbtH gene" downshifts complement(2707743) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2707956..2715092) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" /label="dhbF CDS" gene complement(2707956..2715092) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /label="dhbF gene" CDS complement(2715112..2716050) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" /label="dhbB CDS" gene complement(2715112..2716050) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /label="dhbB gene" CDS complement(2716078..2717697) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" /label="dhbE CDS" gene complement(2716078..2717697) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /label="dhbE gene" CDS complement(2717726..2718922) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" /label="dhbC CDS" gene complement(2717726..2718922) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /label="dhbC gene" promotor_-35 2718770..2718777 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2718792..2718811 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2718799 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2718948..2719733) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" /label="dhbA CDS" gene complement(2718948..2719733) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /label="dhbA gene" S_feature complement(2719734..2719843) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(2719838..2719857) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2719843) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2719845..2719926) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(2719871..2719878) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2719927..2720796) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" /label="besA CDS" gene complement(2719927..2720796) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /label="besA gene" S_feature complement(2720797..2720877) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(2720861..2720880) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2720877) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2720894..2720901) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2721010..2721606) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" /label="yuiH CDS" gene complement(2721010..2721606) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /label="yuiH gene" S_feature complement(2721607..2721691) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 2721642..2721649 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2721659 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2721664..2721683 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2721685..2721699) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2721691) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2721707..2721711) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2721707..2722309 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" /label="bioYB CDS" gene 2721707..2722309 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /label="bioYB gene" downshifts 2722295 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS complement(2722379..2723707) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" /label="hisP CDS" gene complement(2722379..2723707) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /label="hisP gene" downshifts complement(2722395) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2723761..2723780) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2723764) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2723795..2723802) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2723854..2725356) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" /label="pepA CDS" gene complement(2723854..2725356) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /label="pepA gene" downshifts complement(2723869) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2724921..2724935 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2724937 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2725357..2725431) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 2725379..2725386 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2725397..2725416 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2725399..2725513 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 2725399 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2725426..2725445) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2725436) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="upshifts" CDS 2725514..2725990 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" /label="yuiD CDS" gene 2725514..2725990 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /label="yuiD gene" downshifts 2725939 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" /label="downshifts" CDS complement(2726021..2726677) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" /label="spsC CDS" gene complement(2726021..2726677) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /label="spsC gene" downshifts complement(2726049) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2726325..2726334 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2726348..2726367 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2726365 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="upshifts" S_feature 2726367..2726813 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(2726691) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2726693..2726704) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2726719..2726725) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2726770 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" /label="downshifts" CDS complement(2726781..2727101) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" /label="yuiB CDS" gene complement(2726781..2727101) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /label="yuiB gene" downshifts complement(2726795) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" /label="downshifts" S_feature 2726815..2727025 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 2726967..2727067 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2727027..2727136 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 2727027 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="upshifts" downshifts 2727093 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2727120..2727139) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2727125) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" S_feature 2727138..2727689 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(2727154..2727161) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2727155..2727298) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" /label="yuiA CDS" gene complement(2727155..2727298) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /label="yuiA gene" promotor_-10 complement(2727322..2727341) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2727343) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2727357..2727360) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2727471..2728691) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" /label="yumB CDS" gene complement(2727471..2728691) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /label="yumB gene" downshifts complement(2727499) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2728692..2728819) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(2728819) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2728821..2728885) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(2728821..2728839) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2728855..2728860) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2728876..2728895) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2728884) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2728910..2728917) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2728959..2728966 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2728978..2728997 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2728978 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="upshifts" CDS 2729023..2730021 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" /label="trxBB CDS" gene 2729023..2730021 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /label="trxBB gene" promotor_-10 complement(2729046..2729064) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2729061) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2729081..2729086) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2729997 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2730060..2730200) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" /label="yuzG CDS" gene complement(2730060..2730200) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /label="yuzG gene" downshifts complement(2730072) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2730201..2730330) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(2730311..2730330) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2730330) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2730332..2730579) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(2730344..2730350) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2730387..2730394 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2730408..2730427 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2730416 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2730479..2731459 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" /label="guaC CDS" gene 2730479..2731459 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /label="guaC gene" upshifts complement(2730580) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2730584..2730595) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2730609..2730615) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2731427 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2731532) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2731533..2732156) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" /label="paiB CDS" gene complement(2731533..2732156) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /label="paiB gene" CDS complement(2732180..2732698) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" /label="paiA CDS" gene complement(2732180..2732698) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /label="paiA gene" misc_feature complement(2732745..2732764) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2732757) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2732759..2732867) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(2732854..2732871) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2732865) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2732886..2732893) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2733021) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2733036..2733398) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" /label="sufA CDS" gene complement(2733036..2733398) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /label="sufA gene" promotor_-10 complement(2733429..2733448) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2733439) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2733462..2733469) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2733477..2734331) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" /label="dapF CDS" gene complement(2733477..2734331) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /label="dapF gene" promotor_-10 complement(2734047..2734066) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2734055) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2734079..2734088) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2734353..2734372) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2734367) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2734387..2734390) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2734454..2735668) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" /label="yutK CDS" gene complement(2734454..2735668) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /label="yutK gene" promotor_-35 2735003..2735009 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2735024..2735042 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2735031 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="upshifts" S_feature 2735035..2735804 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(2735705..2735724) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(2735710) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="upshifts" promotor_-35 complement(2735739..2735746) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 2735761 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" /label="downshifts" CDS complement(2735805..2736041) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" /label="yuzB CDS" gene complement(2735805..2736041) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /label="yuzB gene" S_feature 2735806..2736222 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(2735823) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2736006..2736007) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2736011..2736015) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2736013) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2736056..2736075) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2736057) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2736089..2736096) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2736199..2736204 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2736218..2736237 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2736224 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="upshifts" CDS 2736304..2737371 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" /label="yutJ CDS" gene 2736304..2737371 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /label="yutJ gene" downshifts 2737355 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" /label="downshifts" CDS complement(2737397..2737723) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" /label="yuzD CDS" gene complement(2737397..2737723) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /label="yuzD gene" downshifts complement(2737420) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2737755..2737774) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2737772) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2737787..2737794) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2737807..2737811 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2737823..2738158 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" /label="yutI CDS" gene 2737823..2738158 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /label="yutI gene" promotor_-10 2737824..2737843 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2737829 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2737948) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2738136 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2738200..2740173) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" /label="yuxL CDS" gene complement(2738200..2740173) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /label="yuxL gene" downshifts complement(2738212) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2740188..2740206) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2740211) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2740218..2740226) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2740281..2741210) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" /label="thrB CDS" gene complement(2740281..2741210) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /label="thrB gene" downshifts complement(2740294) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2741207..2742265) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" /label="thrC CDS" gene complement(2741207..2742265) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /label="thrC gene" CDS complement(2742265..2743566) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" /label="hom CDS" gene complement(2742265..2743566) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /label="hom gene" promotor_-35 2743451..2743460 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2743475..2743494 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2743482 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2743567..2743648) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(2743633..2743652) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2743648) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2743650..2743766) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(2743667..2743674) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2743767..2744786) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" /label="cotNH CDS" gene complement(2743767..2744786) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /label="cotNH gene" promotor_-35 2744594..2744599 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2744615..2744633 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2744619 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2744809..2744827) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2744816) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2744825..2744830 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2744843..2744848) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2744846..2744910 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 2744846..2744864 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2744846 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2744883..2744892 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2744905..2744924 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2744912 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="upshifts" CDS 2744939..2745439 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" /label="yutG CDS" gene 2744939..2745439 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /label="yutG gene" CDS complement(2745466..2746236) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" /label="nucF CDS" gene complement(2745466..2746236) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /label="nucF gene" downshifts complement(2745494) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2746265..2746699) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" /label="yutE CDS" gene complement(2746265..2746699) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /label="yutE gene" CDS complement(2746723..2746998) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" /label="yutD CDS" gene complement(2746723..2746998) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /label="yutD gene" promotor_-10 complement(2747018..2747037) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2747043) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2747045..2747737) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(2747051..2747058) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2747061..2747067 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2747082..2747093 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2747090 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="upshifts" CDS 2747113..2747745 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" /label="yutC CDS" gene 2747113..2747745 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /label="yutC gene" downshifts 2747706 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2747761..2748657) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" /label="lipA CDS" gene complement(2747761..2748657) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /label="lipA gene" downshifts complement(2747782) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(2748658..2748792) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(2748779..2748798) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(2748792) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="upshifts" promotor_-35 complement(2748814..2748818) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 2748832..2748838 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2748852..2748863 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2748864 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="upshifts" CDS 2748892..2749872 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" /label="lytH CDS" gene 2748892..2749872 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /label="lytH gene" upshifts complement(2748970) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2748984..2749003) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2749020..2749023) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2749864 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2749900..2750664) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" /label="fisB CDS" gene complement(2749900..2750664) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /label="fisB gene" downshifts complement(2749916) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2750678..2750696) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2750686) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2750712..2750717) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2750737..2751042) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " /label="yunC CDS" gene complement(2750737..2751042) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /label="yunC gene" downshifts complement(2750745) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2751056..2751075) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2751079) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2751089..2751097) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2751107..2752495) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" /label="yunD CDS" gene complement(2751107..2752495) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /label="yunD gene" CDS complement(2752515..2753336) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" /label="yunE CDS" gene complement(2752515..2753336) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /label="yunE gene" CDS complement(2753354..2754202) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" /label="yunF CDS" gene complement(2753354..2754202) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /label="yunF gene" promotor_-35 2753721..2753726 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2753742..2753760 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2753756 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2754213..2754232) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2754228) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2754240..2754587) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" /label="yunG CDS" gene complement(2754240..2754587) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /label="yunG gene" promotor_-10 complement(2754600..2754619) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2754619) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2754633..2754639) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2754684..2756024) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" /label="pucH CDS" gene complement(2754684..2756024) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /label="pucH gene" downshifts complement(2754712) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" /label="downshifts" downshifts complement(2755768) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" /label="downshifts" promotor_-35 2756081..2756087 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2756101..2756120 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2756103..2756121) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2756109 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2756110..2756198 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(2756120) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2756137..2756142) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2756199..2757794 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" /label="pucR CDS" gene 2756199..2757794 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /label="pucR gene" CDS 2757939..2759288 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " /label="pucJ CDS" gene 2757939..2759288 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /label="pucJ gene" CDS 2759294..2760586 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" /label="pucK CDS" gene 2759294..2760586 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /label="pucK gene" CDS 2760599..2762083 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" /label="pucL CDS" gene 2760599..2762083 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /label="pucL gene" CDS 2762083..2762427 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" /label="pucM CDS" gene 2762083..2762427 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /label="pucM gene" promotor_-35 2762149..2762152 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2762170..2762189 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2762182 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2762402 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2762443..2762830) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 2762790..2762799 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2762812..2762831 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2762815 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="upshifts" ncRNA complement(2762851..2762982) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" /label="auzJ ncRNA" CDS 2762851..2762982 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " /label="yuzJ CDS" gene 2762851..2762982 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /label="yuzJ gene" gene complement(2762851..2762982) /gene="auzJ" /locus_tag="BSU_ncRNA_2" /label="auzJ gene" S_feature 2762983..2763051 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 2763018 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2763188..2763709) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" /label="pucE CDS" gene complement(2763188..2763709) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /label="pucE gene" CDS complement(2763700..2765937) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" /label="pucD CDS" gene complement(2763700..2765937) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /label="pucD gene" CDS complement(2765938..2766771) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" /label="pucC CDS" gene complement(2765938..2766771) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /label="pucC gene" CDS complement(2766768..2767385) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" /label="pucB CDS" gene complement(2766768..2767385) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /label="pucB gene" downshifts complement(2766877) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" /label="downshifts" CDS complement(2767382..2768374) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" /label="pucA CDS" gene complement(2767382..2768374) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /label="pucA gene" S_feature complement(2768375..2768461) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(2768439..2768458) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2768461) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2768472..2768477) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2768603..2769853) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" /label="pucG CDS" gene complement(2768603..2769853) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /label="pucG gene" CDS complement(2769870..2771108) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" /label="pucF CDS" gene complement(2769870..2771108) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /label="pucF gene" CDS 2771331..2771468 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" /label="hypothetical protein CDS" gene 2771331..2771468 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /label="gene" promotor_-35 2771490..2771493 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2771508..2771527 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2771509 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="upshifts" CDS 2771550..2772416 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" /label="bsnA CDS" gene 2771550..2772416 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /label="bsnA gene" downshifts 2772419 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2772450..2773553) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" /label="frlP CDS" gene complement(2772450..2773553) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /label="frlP gene" downshifts complement(2772465) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2773554..2774487) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 2773591..2773598 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2773612..2773631 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2773622 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2773673..2773679 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2773690 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2773694..2773713 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2773735..2774463 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" /label="frlR CDS" gene 2773735..2774463 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /label="frlR gene" CDS complement(2774488..2775342) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" /label="frlD CDS" gene complement(2774488..2775342) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /label="frlD gene" misc_feature complement(2774675..2774694) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2774687) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2774845..2774945) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2774885) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2775356..2776258) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" /label="frlM CDS" gene complement(2775356..2776258) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /label="frlM gene" CDS complement(2776262..2777140) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" /label="frlN CDS" gene complement(2776262..2777140) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /label="frlN gene" CDS complement(2777198..2778466) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" /label="frlO CDS" gene complement(2777198..2778466) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /label="frlO gene" promotor_no_box 2778357..2778457 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2778417 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2778537) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS complement(2778547..2779533) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" /label="frlB CDS" gene complement(2778547..2779533) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /label="frlB gene" upshifts 2779480 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2779483..2779487 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2779576..2779595) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2779589) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2779610..2779617) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2779747) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2779749..2780123) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" /label="yurQ CDS" gene complement(2779749..2780123) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /label="yurQ gene" upshifts complement(2780187) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2780194..2780205) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2780219..2780225) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2780226..2781344) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" /label="dadA CDS" gene complement(2780226..2781344) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /label="dadA gene" promotor_-10 complement(2781369..2781388) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2781375) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2781377..2781987) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(2781402..2781408) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2781441..2781450 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2781464..2781483 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2781468 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2781481..2781496) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2781485) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2781503..2781507) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2781503..2781649 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" /label="sspG CDS" gene 2781503..2781649 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /label="sspG gene" CDS 2781649..2781924 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" /label="yurS CDS" gene 2781649..2781924 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /label="yurS gene" upshifts complement(2781793) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2781809..2781823) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2781832..2781836) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2781904 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2781988..2782371) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" /label="glxB CDS" gene complement(2781988..2782371) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /label="glxB gene" S_feature complement(2782372..2782481) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(2782482..2782760) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" /label="yuzN CDS" gene complement(2782482..2782760) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /label="yuzN gene" promotor_-10 complement(2782758..2782777) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2782782) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2782792..2782799) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2782923..2783029) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(2782966) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2783030..2784427) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" /label="sufB CDS" gene complement(2783030..2784427) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /label="sufB gene" downshifts 2784225 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS complement(2784448..2784891) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" /label="sufU CDS" gene complement(2784448..2784891) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /label="sufU gene" CDS complement(2784881..2786101) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" /label="sufS CDS" gene complement(2784881..2786101) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /label="sufS gene" CDS complement(2786101..2787414) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" /label="sufD CDS" gene complement(2786101..2787414) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /label="sufD gene" CDS complement(2787432..2788217) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" /label="sufC CDS" gene complement(2787432..2788217) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /label="sufC gene" promotor_-10 complement(2788261..2788280) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2788262) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" promotor_-35 complement(2788294..2788301) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(2788318..2788337) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(2788327) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" S_feature complement(2788329..2788410) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(2788353..2788357) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(2788374..2788621) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" /label="bsrI RNA" gene complement(2788374..2788621) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /label="bsrI gene" CDS complement(2788411..2788548) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" /label="yuzK CDS" gene complement(2788411..2788548) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /label="yuzK gene" S_feature complement(2788549..2788633) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(2788617..2788636) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2788633) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2788635..2788741) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(2788652..2788655) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2788742..2789119) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" /label="yurZ CDS" gene complement(2788742..2789119) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /label="yurZ gene" promotor_-10 complement(2789136..2789147) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(2789142) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="upshifts" promotor_-35 complement(2789161..2789167) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(2789204..2790028) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" /label="metQ CDS" gene complement(2789204..2790028) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /label="metQ gene" downshifts complement(2789212) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2789361) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-35 2789388..2789393 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2789409..2789427 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2789411 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2790042..2790710) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" /label="metP CDS" gene complement(2790042..2790710) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /label="metP gene" CDS complement(2790703..2791728) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" /label="metN CDS" gene complement(2790703..2791728) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /label="metN gene" S_feature complement(2791729..2791833) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(2791834..2791940) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswH RNA" gene complement(2791834..2791940) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /label="mswH gene" downshifts 2791903 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2791967..2791986) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2791979) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2791981..2792054) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(2792002..2792009) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2792055..2792399) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" /label="yusD CDS" gene complement(2792055..2792399) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /label="yusD gene" S_feature complement(2792400..2792505) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(2792506..2792826) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" /label="yusE CDS" gene complement(2792506..2792826) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /label="yusE gene" CDS complement(2792828..2793268) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" /label="yusF CDS" gene complement(2792828..2793268) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /label="yusF gene" CDS complement(2793268..2793504) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" /label="yusG CDS" gene complement(2793268..2793504) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /label="yusG gene" downshifts complement(2793280) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" /label="downshifts" upshifts complement(2793519) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2793524..2793535) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2793550..2793556) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2793560..2793943) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" /label="gcvH CDS" gene complement(2793560..2793943) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /label="gcvH gene" promotor_-10 complement(2793970..2793989) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(2793981) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="upshifts" promotor_-35 complement(2794002..2794009) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(2794010..2794366) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" /label="yusI CDS" gene complement(2794010..2794366) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /label="yusI gene" promotor_-10 complement(2794389..2794408) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(2794399) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="upshifts" promotor_-35 complement(2794422..2794427) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(2794477..2796261) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" /label="fadE CDS" gene complement(2794477..2796261) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /label="fadE gene" downshifts complement(2794487) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2796276..2797451) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " /label="fadA CDS" gene complement(2796276..2797451) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /label="fadA gene" CDS complement(2797462..2799831) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" /label="fadN CDS" gene complement(2797462..2799831) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /label="fadN gene" promotor_-35 2799250..2799255 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2799270..2799288 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2799273 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2799899..2799918) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(2799902) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="upshifts" S_feature complement(2799910..2800176) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(2799932..2799939) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 2799957..2799963 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2799978..2799989 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2800000 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="upshifts" CDS 2800006..2800152 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" /label="yuzL CDS" gene 2800006..2800152 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /label="yuzL gene" S_feature 2800153..2801179 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(2800177..2801085) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" /label="putM CDS" gene complement(2800177..2801085) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /label="putM gene" S_feature complement(2801086..2801608) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 2801180..2801425 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" /label="yuzM CDS" gene 2801180..2801425 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /label="yuzM gene" CDS 2801438..2801770 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" /label="yusN CDS" gene 2801438..2801770 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /label="yusN gene" promotor_-10 complement(2801591..2801610) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2801608) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2801624..2801633) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2801759 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2801831..2801838 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2801852..2801871 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2801863 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="upshifts" CDS 2801929..2802396 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" /label="mdtR CDS" gene 2801929..2802396 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /label="mdtR gene" CDS 2802393..2804018 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" /label="mdtP CDS" gene 2802393..2804018 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /label="mdtP gene" downshifts 2804003 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2804054..2804437) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" /label="yusQ CDS" gene complement(2804054..2804437) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /label="yusQ gene" CDS complement(2804456..2804845) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" /label="yusR CDS" gene complement(2804456..2804845) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /label="yusR gene" CDS complement(2804867..2805196) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" /label="yusS CDS" gene complement(2804867..2805196) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /label="yusS gene" promotor_-10 complement(2805231..2805250) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2805238..2805245 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2805245) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2805260..2805279 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2805264..2805271) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2805270 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="upshifts" CDS 2805330..2806217 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" /label="yusT CDS" gene 2805330..2806217 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /label="yusT gene" CDS complement(2806237..2806524) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" /label="yusU CDS" gene complement(2806237..2806524) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /label="yusU gene" downshifts complement(2806249) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2806549..2807376) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " /label="feuV CDS" gene complement(2806549..2807376) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /label="feuV gene" downshifts complement(2806565) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" /label="downshifts" S_feature complement(2807377..2807514) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(2807499..2807518) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2807514) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2807534..2807537) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2807594..2808031) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" /label="cotNW CDS" gene complement(2807594..2808031) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /label="cotNW gene" promotor_-10 complement(2808055..2808073) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(2808061) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="upshifts" promotor_-35 complement(2808089..2808094) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(2808141..2809649) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" /label="yusYc CDS" gene complement(2808141..2809649) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo /label="yusYc gene" downshifts complement(2808162) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(2809640..2809936) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" /label="yusYn CDS" gene complement(2809640..2809936) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo /label="yusYn gene" promotor_-10 complement(2809959..2809978) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2809975) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2809993..2809996) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2810013..2810018 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2810030..2810049 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2810030 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="upshifts" CDS 2810070..2810912 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" /label="yusZ CDS" gene 2810070..2810912 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /label="yusZ gene" promotor_-35 2810442..2810448 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 2810463..2810474 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 2810471 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="upshifts" promotor_-35 2810939..2810946 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2810955 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2810958..2810977 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2811002..2811463 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" /label="mrgA CDS" gene 2811002..2811463 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /label="mrgA gene" downshifts 2811439 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2811507..2812883) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" /label="htrB CDS" gene complement(2811507..2812883) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /label="htrB gene" downshifts complement(2811515) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2812884..2813055) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(2813036..2813055) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2813055) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2813066..2813073) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2813116..2813135) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 2813126..2813145 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2813128 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2813134) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="upshifts" S_feature complement(2813136..2814199) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(2813150..2813157) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 2813161..2813838 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" /label="cssR CDS" gene 2813161..2813838 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /label="cssR gene" CDS 2813835..2815190 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" /label="cssS CDS" gene 2813835..2815190 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /label="cssS gene" S_feature complement(2814289..2815217) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 2815158 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2815218..2815382) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" /label="spxO CDS" gene complement(2815218..2815382) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /label="spxO gene" promotor_-35 2815406..2815413 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2815427..2815446 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2815431..2815450) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2815437..2815549 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 2815437 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2815444) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2815446..2815724) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(2815464..2815471) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2815550..2816425 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" /label="yuxN CDS" gene 2815550..2816425 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /label="yuxN gene" promotor_-10 complement(2815714..2815733) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2815724) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2815726..2816267) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(2815747..2815754) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2816259..2816277) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2816267) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2816269..2816398) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(2816290..2816297) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2816400 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" downshifts complement(2816443) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(2816461..2817849) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" /label="fumC CDS" gene complement(2816461..2817849) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /label="fumC gene" upshifts complement(2817873) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2817878..2817896) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2817907..2817915) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2817916..2818101) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" /label="yvzF CDS" gene complement(2817916..2818101) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /label="yvzF gene" downshifts 2818105 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2818145..2818164) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2818154..2818160 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2818159) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2818174..2818185 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2818177 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2818180..2818183) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2818219..2819667 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" /label="gerAA CDS" gene 2818219..2819667 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /label="gerAA gene" S_feature complement(2819215..2821858) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 2819636..2820733 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" /label="gerAB CDS" gene 2819636..2820733 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /label="gerAB gene" CDS 2820730..2821851 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" /label="gerAC CDS" gene 2820730..2821851 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /label="gerAC gene" CDS complement(2821859..2822494) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" /label="liaR CDS" gene complement(2821859..2822494) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /label="liaR gene" CDS complement(2822472..2823554) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" /label="liaS CDS" gene complement(2822472..2823554) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /label="liaS gene" CDS complement(2823551..2824276) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" /label="liaF CDS" gene complement(2823551..2824276) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /label="liaF gene" CDS complement(2824310..2825182) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" /label="liaG CDS" gene complement(2824310..2825182) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /label="liaG gene" promotor_-10 complement(2825201..2825220) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2825221) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2825235..2825238) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2825283..2825960) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" /label="liaH CDS" gene complement(2825283..2825960) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /label="liaH gene" downshifts complement(2825299) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" /label="downshifts" CDS complement(2825987..2826367) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" /label="liaI CDS" gene complement(2825987..2826367) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /label="liaI gene" promotor_-10 complement(2826390..2826409) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2826410) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2826424..2826427) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2826529..2827797) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" /label="yvqJ CDS" gene complement(2826529..2827797) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /label="yvqJ gene" downshifts complement(2826542) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2827831..2827850) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2827842) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2827865..2827872) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2827968) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2827974..2828555) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" /label="yvqK CDS" gene complement(2827974..2828555) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /label="yvqK gene" CDS complement(2828578..2829906) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" /label="yvrA CDS" gene complement(2828578..2829906) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /label="yvrA gene" CDS complement(2829906..2830967) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" /label="yvrB CDS" gene complement(2829906..2830967) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /label="yvrB gene" CDS complement(2830930..2831874) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" /label="yvrC CDS" gene complement(2830930..2831874) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /label="yvrC gene" S_feature complement(2831875..2832144) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(2831983..2832113) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" /label="srbL RNA" gene complement(2831983..2832113) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /label="srbL gene" promotor_-10 complement(2832121..2832140) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2832144) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2832146..2833073) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(2832156..2832163) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2832206..2832213 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2832228..2832247 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2832232 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="upshifts" CDS 2832272..2833063 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" /label="yvrD CDS" gene 2832272..2833063 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /label="yvrD gene" downshifts 2832934 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 2833044 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2833101..2833979) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" /label="yvrE CDS" gene complement(2833101..2833979) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /label="yvrE gene" downshifts complement(2833118) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2834003..2834021) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2834022) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2834035..2834041) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2834051..2835793) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" /label="yvrG CDS" gene complement(2834051..2835793) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /label="yvrG gene" CDS complement(2835790..2836503) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" /label="yvrH CDS" gene complement(2835790..2836503) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /label="yvrH gene" misc_feature complement(2836534..2836553) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2836552) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="upshifts" CDS complement(2836656..2836895) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" /label="rsoA CDS" gene complement(2836656..2836895) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /label="rsoA gene" downshifts complement(2836663) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2836891..2836909) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2836899..2837429) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" /label="sigO CDS" gene complement(2836899..2837429) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /label="sigO gene" upshifts complement(2836900) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2836924..2836930) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2837432..2837451) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2837439) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" CDS 2837444..2837782 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" /label="yvrJ CDS" gene 2837444..2837782 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /label="yvrJ gene" promotor_-35 complement(2837466..2837473) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2837482..2837501) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2837494) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2837516..2837522) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2837528..2837628 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 2837588 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="upshifts" promotor_no_box 2837756..2837856 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2837816..2837902 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 2837816 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="upshifts" CDS 2837903..2839060 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" /label="oxdC CDS" gene 2837903..2839060 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /label="oxdC gene" downshifts 2839046 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 2839121..2839531 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" /label="rsiO CDS" gene 2839121..2839531 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /label="rsiO gene" downshifts 2839530 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2839565..2840794) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" /label="yvrN CDS" gene complement(2839565..2840794) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /label="yvrN gene" downshifts complement(2839582) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2840787..2841476) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" /label="yvrO CDS" gene complement(2840787..2841476) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /label="yvrO gene" CDS complement(2841460..2842653) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" /label="yvrP CDS" gene complement(2841460..2842653) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /label="yvrP gene" promotor_-10 complement(2842697..2842716) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2842710) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2842731..2842738) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2842824..2843633) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" /label="fhuC CDS" gene complement(2842824..2843633) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /label="fhuC gene" downshifts complement(2842841) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2842980..2842989 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2843002..2843021 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2843006 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2843649..2844659) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" /label="fhuG CDS" gene complement(2843649..2844659) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /label="fhuG gene" CDS complement(2844659..2845813) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" /label="fhuB CDS" gene complement(2844659..2845813) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /label="fhuB gene" promotor_-10 complement(2845746..2845765) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2845763) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2845777..2845784) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2845825..2845832 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2845847..2845866 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2845856 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2845911..2846858 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" /label="fhuD CDS" gene 2845911..2846858 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /label="fhuD gene" downshifts 2846834 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 2846878 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2847032 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(2847093..2848502) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" /label="lysP CDS" gene complement(2847093..2848502) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /label="lysP gene" downshifts complement(2847108) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2847920..2847924 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2847942..2847958 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2847949 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="upshifts" S_feature 2847956..2848923 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(2848604) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" misc_RNA complement(2848606..2848785) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" /label="kswB RNA" gene complement(2848606..2848785) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /label="kswB gene" promotor_-10 complement(2848815..2848832) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2848826) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2848847..2848854) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2848880 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(2848902..2849042) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" /label="sspJ CDS" gene complement(2848902..2849042) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /label="sspJ gene" downshifts complement(2848912) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" upshifts complement(2849070) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="upshifts" S_feature complement(2849072..2849660) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(2849075..2849086) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(2849100..2849106) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 2849132..2849139 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2849153 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2849155..2849174 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2849209..2849691 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" /label="yvsG CDS" gene 2849209..2849691 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /label="yvsG gene" promotor_-35 2849705..2849712 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2849726..2849745 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2849738 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2849791..2851644 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" /label="ltaSP CDS" gene 2849791..2851644 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /label="ltaSP gene" downshifts 2851630 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2851672..2852598) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" /label="yvgK CDS" gene complement(2851672..2852598) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /label="yvgK gene" downshifts complement(2851684) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2852610..2852629) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2852631) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2852645..2852648) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2852667..2852686 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2852676 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="upshifts" CDS 2852709..2853491 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" /label="modA CDS" gene 2852709..2853491 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /label="modA gene" CDS 2853463..2854155 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" /label="modB CDS" gene 2853463..2854155 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /label="modB gene" downshifts 2854147 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" /label="downshifts" CDS complement(2854186..2855016) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" /label="pgoN CDS" gene complement(2854186..2855016) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /label="pgoN gene" downshifts complement(2854192) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2854879..2854883 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2854899..2854903 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2854908 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2855018 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2855046..2855065) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2855064) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2855080..2855087) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2855172..2855178 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2855192 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2855193..2855211 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2855239..2855724 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" /label="yvgO CDS" gene 2855239..2855724 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /label="yvgO gene" downshifts 2855723 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" /label="downshifts" CDS complement(2855768..2857780) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" /label="nhaK CDS" gene complement(2855768..2857780) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /label="nhaK gene" downshifts complement(2855776) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2857446..2857450) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2857448) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2857781..2857932) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(2857909..2857927) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2857932) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2858035..2859750) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" /label="cysI CDS" gene complement(2858035..2859750) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /label="cysI gene" downshifts complement(2858042) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" CDS complement(2859776..2861593) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" /label="cysJ CDS" gene complement(2859776..2861593) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /label="cysJ gene" promotor_-10 complement(2861635..2861654) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2861644..2861651 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2861654) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" upshifts 2861657 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2861664..2861683 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2861667..2861674) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2861764..2864088) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" /label="helD CDS" gene complement(2861764..2864088) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /label="helD gene" downshifts complement(2861782) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2864108..2864115 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2864130..2864149 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2864131..2864146) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2864134 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2864136) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2864181..2864200) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2864190) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2864216..2864222) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2864226..2864245) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2864246) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2864259..2864267) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2864273) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" /label="downshifts" CDS complement(2864286..2864894) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" /label="yvgT CDS" gene complement(2864286..2864894) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /label="yvgT gene" promotor_-10 complement(2864933..2864952) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2864950) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2864968..2864972) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2865081..2865497) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" /label="bdbC CDS" gene complement(2865081..2865497) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /label="bdbC gene" downshifts complement(2865091) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2865502..2866170) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" /label="bdbD CDS" gene complement(2865502..2866170) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /label="bdbD gene" promotor_-10 complement(2866222..2866241) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2866237) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2866248) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2866255..2866260) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2866290..2868398) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" /label="cadA CDS" gene complement(2866290..2868398) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /label="cadA gene" S_feature complement(2868390..2868491) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(2868485..2868504) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2868491) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2868520..2868527) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2868558..2870966) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" /label="copA CDS" gene complement(2868558..2870966) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /label="copA gene" downshifts complement(2868580) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2868646) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2870967..2871049) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(2871050..2871259) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" /label="copZ CDS" gene complement(2871050..2871259) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /label="copZ gene" promotor_-10 complement(2871283..2871302) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(2871304) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="upshifts" promotor_-35 complement(2871315..2871321) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(2871333..2871638) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " /label="csoR CDS" gene complement(2871333..2871638) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /label="csoR gene" misc_feature 2871602..2871621 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2871613 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2871652..2871671) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(2871678) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="upshifts" promotor_-35 complement(2871685..2871691) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 2871730..2871736 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2871751..2871769 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2871759 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2871766..2872842 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" /label="iolW CDS" gene 2871766..2872842 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /label="iolW gene" downshifts 2872829 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2872879..2873514) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" /label="azoRB CDS" gene complement(2872879..2873514) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /label="azoRB gene" downshifts complement(2872892) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2873515..2873612) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(2873592..2873611) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2873612) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2873625..2873631) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2873674..2875569) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" /label="yvaC CDS" gene complement(2873674..2875569) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /label="yvaC gene" promotor_-10 complement(2875620..2875631) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2875620) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2875646..2875652) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2875719) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(2875732..2876133) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" /label="yvaD CDS" gene complement(2875732..2876133) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /label="yvaD gene" CDS complement(2876130..2876489) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" /label="yvaE CDS" gene complement(2876130..2876489) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /label="yvaE gene" CDS complement(2876486..2877058) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" /label="yvaF CDS" gene complement(2876486..2877058) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /label="yvaF gene" promotor_-10 complement(2877096..2877115) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2877101) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2877129..2877136) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2877169..2877963) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" /label="yvaG CDS" gene complement(2877169..2877963) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /label="yvaG gene" promotor_-10 complement(2877984..2878002) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2877996) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2878017..2878023) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2878029..2878048) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2878040) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2878042..2878107) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(2878062..2878069) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2878149..2878508) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" /label="ssrA RNA" gene complement(2878149..2878508) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /label="ssrA gene" downshifts complement(2878152) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2878492..2878500) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2878502) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2878515..2878520) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2878560..2878579) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2878568) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2878570..2878634) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(2878592..2878596) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2878634) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="upshifts" promotor_-10 complement(2878635..2878654) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(2878669..2878676) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(2878685..2879155) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" /label="smpB CDS" gene complement(2878685..2879155) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /label="smpB gene" promotor_no_box 2878982..2879082 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2879042 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2879152 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2879200..2879219) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2879206) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" S_feature complement(2879208..2879299) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(2879235..2879238) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(2879300..2881639) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" /label="rnr CDS" gene complement(2879300..2881639) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /label="rnr gene" promotor_-35 2880400..2880403 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2880419..2880422 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2880428 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2881658..2882398) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" /label="estA CDS" gene complement(2881658..2882398) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /label="estA gene" promotor_-10 complement(2882054..2882072) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(2882066) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="upshifts" promotor_-35 complement(2882087..2882093) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(2882426..2882444) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2882440) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="upshifts" downshifts complement(2882528) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" /label="downshifts" CDS complement(2882530..2882760) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" /label="secG CDS" gene complement(2882530..2882760) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /label="secG gene" promotor_-10 complement(2882790..2882809) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(2882811) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" promotor_-35 complement(2882824..2882827) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 2882849..2882855 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2882869..2882880 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2882870 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="upshifts" CDS 2882909..2883679 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" /label="yvaM CDS" gene 2882909..2883679 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /label="yvaM gene" promotor_-35 2882931..2882939 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2882950..2882968 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2882980 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2883719..2883952) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" /label="yvzC CDS" gene complement(2883719..2883952) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /label="yvzC gene" promotor_-35 2884043..2884050 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 2884058 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="upshifts" promotor_-10 2884062..2884081 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 2884104..2884511 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" /label="rghRA CDS" gene 2884104..2884511 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /label="rghRA gene" CDS 2884541..2884960 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" /label="rghRB CDS" gene 2884541..2884960 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /label="rghRB gene" promotor_-35 2884998..2885005 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2885019..2885038 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2885026 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2885052..2885378 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" /label="catR CDS" gene 2885052..2885378 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /label="catR gene" S_feature 2885379..2885463 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 2885434..2885441 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2885454..2885472 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2885465 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 2885503..2887203 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" /label="yvaQ CDS" gene 2885503..2887203 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /label="yvaQ gene" S_feature complement(2886219..2887212) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 2887181 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2887243..2887923) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" /label="opuBD CDS" gene complement(2887243..2887923) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /label="opuBD gene" downshifts complement(2887257) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2887617..2887623 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2887638..2887656 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2887643..2890394 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 2887643 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2887940..2888860) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" /label="opuBC CDS" gene complement(2887940..2888860) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /label="opuBC gene" CDS complement(2888872..2889525) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " /label="opuBB CDS" gene complement(2888872..2889525) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /label="opuBB gene" CDS complement(2889542..2890687) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" /label="opuBA CDS" gene complement(2889542..2890687) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /label="opuBA gene" S_feature complement(2890688..2890755) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(2890755) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2890756..2890775) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2890786..2890790 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2890790..2890793) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2890806..2890824 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2890811 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2890906..2890910 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2890926..2890945 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2890929 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" CDS 2890971..2891504 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" /label="yvaV CDS" gene 2890971..2891504 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /label="yvaV gene" S_feature complement(2891171..>2891570) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 2891493 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(2891570,2891577) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs14" N_region 2891571..2891576 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs14" S_feature <2891577..2891652 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" S_feature complement(<2891577..2891643) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" CDS complement(2891648..2892337) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" /label="opuCD CDS" gene complement(2891648..2892337) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /label="opuCD gene" downshifts complement(2891688) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" promotor_-35 2892280..2892288 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2892302..2892321 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2892316 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2892355..2893266) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" /label="opuCC CDS" gene complement(2892355..2893266) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /label="opuCC gene" CDS complement(2893286..2893939) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " /label="opuCB CDS" gene complement(2893286..2893939) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /label="opuCB gene" CDS complement(2893962..2895104) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" /label="opuCA CDS" gene complement(2893962..2895104) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /label="opuCA gene" promotor_-10 complement(2895148..2895167) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(2895163) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="upshifts" promotor_-35 complement(2895182..2895185) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 2895301..2895308 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2895321..2895340 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2895332 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="upshifts" CDS 2895368..2895925 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" /label="opcR CDS" gene 2895368..2895925 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /label="opcR gene" S_feature 2895926..2896690 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(2895943..2896578) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" /label="yvbG CDS" gene complement(2895943..2896578) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /label="yvbG gene" downshifts complement(2895956) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2896619..2896637) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2896625) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2896653..2896659) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2896664..2896671 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2896683..2896702 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2896692 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2896728..2897342 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" /label="yvbH CDS" gene 2896728..2897342 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /label="yvbH gene" downshifts 2897328 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 2897396..2897399 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2897414..2897433 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2897422 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 2897474..2898172 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" /label="yvbI CDS" gene 2897474..2898172 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /label="yvbI gene" downshifts 2898145 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2898208..2900025) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" /label="yvbJ CDS" gene complement(2898208..2900025) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /label="yvbJ gene" downshifts complement(2898227) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(2898398) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" misc_feature complement(2900067..2900086) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 2900071..2900090 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2900076 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2900080) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2900145..2900612 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" /label="yvbK CDS" gene 2900145..2900612 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /label="yvbK gene" downshifts 2900609 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(2900657..2901949) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" /label="eno CDS" gene complement(2900657..2901949) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /label="eno gene" downshifts complement(2900667) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2901979..2903514) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" /label="pgm CDS" gene complement(2901979..2903514) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /label="pgm gene" CDS complement(2903507..2904268) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" /label="tpiA CDS" gene complement(2903507..2904268) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /label="tpiA gene" CDS complement(2904299..2905483) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" /label="pgk CDS" gene complement(2904299..2905483) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /label="pgk gene" S_feature complement(2905484..2905724) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(2905724) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2905726..2905799) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(2905738..2905757) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2905773..2905777) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2905800..2906807) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" /label="gapA CDS" gene complement(2905800..2906807) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /label="gapA gene" promotor_-35 2906726..2906729 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2906746..2906748 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2906748 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2906854..2907876) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" /label="cggR CDS" gene complement(2906854..2907876) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /label="cggR gene" upshifts complement(2906870) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2906898..2906899) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2907877..2907988) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 2907914 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2907969..2907988) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2907988) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2907990..2908100) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(2908002..2908009) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2908083..2908102) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(2908098) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="upshifts" promotor_-35 complement(2908115..2908124) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(2908174..2909568) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" /label="araE CDS" gene complement(2908174..2909568) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /label="araE gene" downshifts complement(2908188) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2909667..2909686) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2909681) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2909701..2909708) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2909708..2909715 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2909729..2909748 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2909735 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="upshifts" CDS 2909772..2910860 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" /label="araR CDS" gene 2909772..2910860 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /label="araR gene" downshifts 2910840 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2910909..2911919) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" /label="yvbT CDS" gene complement(2910909..2911919) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /label="yvbT gene" downshifts complement(2910916) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2911920..2911997) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(2911987..2912006) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2911997) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2912020..2912027) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2912076..2912954) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" /label="yvbU CDS" gene complement(2912076..2912954) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /label="yvbU gene" promotor_-35 2912612..2912618 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2912633..2912644 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2912644 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2912988..2912995 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2913001..2913020) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(2913006) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="upshifts" promotor_-10 2913009..2913028 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2913011 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2913034..2913038) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 2913054..2913971 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" /label="cyeB CDS" gene 2913054..2913971 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /label="cyeB gene" downshifts 2913960 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2914012..2915355) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" /label="yvbW CDS" gene complement(2914012..2915355) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /label="yvbW gene" misc_RNA complement(2915424..2915659) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" /label="tboX RNA" gene complement(2915424..2915659) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /label="tboX gene" downshifts complement(2915558) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2915660..2915756) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(2915757..2916791) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" /label="yvbX CDS" gene complement(2915757..2916791) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /label="yvbX gene" promotor_-10 complement(2916813..2916831) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2916819) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2916844..2916851) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2916899..2917621) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" /label="lutC CDS" gene complement(2916899..2917621) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /label="lutC gene" downshifts complement(2916915) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" /label="downshifts" CDS complement(2917621..2919060) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" /label="lutB CDS" gene complement(2917621..2919060) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /label="lutB gene" promotor_-35 2918608..2918611 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2918628 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2918629..2918633 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2918782 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 2918936 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2918937..2918938 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2919087..2919803) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" /label="lutA CDS" gene complement(2919087..2919803) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /label="lutA gene" promotor_-35 2919707..2919714 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2919728..2919730 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2919728 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2919801 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" S_feature complement(2919804..2919870) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(2919867..2919886) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(2919870) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="upshifts" promotor_-35 complement(2919901..2919908) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(2919978..2920580) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" /label="yvfU CDS" gene complement(2919978..2920580) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /label="yvfU gene" CDS complement(2920597..2921712) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" /label="yvfT CDS" gene complement(2920597..2921712) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /label="yvfT gene" CDS complement(2921716..2922453) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" /label="yvfS CDS" gene complement(2921716..2922453) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /label="yvfS gene" promotor_-10 complement(2921742..2921761) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(2921756) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="upshifts" promotor_-35 complement(2921773..2921780) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(2922454..2923359) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" /label="yvfR CDS" gene complement(2922454..2923359) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /label="yvfR gene" promotor_-10 complement(2923379..2923397) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2923390) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2923413..2923416) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2923568..2923575 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2923586..2923605 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2923593 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="upshifts" CDS 2923643..2924452 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" /label="rsbQ CDS" gene 2923643..2924452 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /label="rsbQ gene" CDS 2924488..2925699 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" /label="rsbP CDS" gene 2924488..2925699 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /label="rsbP gene" downshifts 2925686 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2925753..2927042) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" /label="ganB CDS" gene complement(2925753..2927042) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /label="ganB gene" CDS complement(2927122..2929185) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" /label="ganA CDS" gene complement(2927122..2929185) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /label="ganA gene" CDS complement(2929204..2930055) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" /label="ganQ CDS" gene complement(2929204..2930055) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /label="ganQ gene" CDS complement(2930059..2931315) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" /label="ganP CDS" gene complement(2930059..2931315) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /label="ganP gene" CDS complement(2931355..2932620) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" /label="ganS CDS" gene complement(2931355..2932620) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /label="ganS gene" promotor_-10 complement(2932652..2932671) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2932674) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2932686..2932693) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2932761..2933753) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" /label="ganR CDS" gene complement(2932761..2933753) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /label="ganR gene" downshifts complement(2932795) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" /label="downshifts" S_feature complement(2933883..2933932) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(2933906) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2933933..2934592) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" /label="lutR CDS" gene complement(2933933..2934592) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /label="lutR gene" S_feature complement(2934593..2934698) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(2934690..2934709) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2934699) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2934724..2934727) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2934751..2934758 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2934773..2934792 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2934773 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="upshifts" S_feature 2934776..2934881 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(2934782..2934799) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2934786) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2934807..2934813) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2934882..2936573 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" /label="lutP CDS" gene 2934882..2936573 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /label="lutP gene" downshifts 2936558 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2936600..2937910) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" /label="sigL CDS" gene complement(2936600..2937910) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /label="sigL gene" S_feature 2936603..2937673 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(2936612) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2937730..2937749 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2937730..2937988 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 2937730 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2937924..2937943) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2937939) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2937958..2937961) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2937989..2938207 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" /label="yvfG CDS" gene 2937989..2938207 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /label="yvfG gene" downshifts 2938186 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" SCAR join(2938214,2938221) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs26" N_region 2938215..2938220 /note="EcoR site (GAATTC)" /created_by="User" /modified_by="User" /label="IIG_Bs26" promotor_-35 2938252..2938255 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2938261 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2938272..2938290 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2938306..2939775 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" /label="pnbA CDS" gene 2938306..2939775 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /label="pnbA gene" downshifts 2939752 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS 2939778..2939969 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" /label="hypothetical protein CDS" gene 2939778..2939969 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /label="gene" downshifts 2939948 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2939996..2940481) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" /label="padC CDS" gene complement(2939996..2940481) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /label="padC gene" CDS complement(2940504..2940815) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" /label="yveG CDS" gene complement(2940504..2940815) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo /label="yveG gene" CDS complement(2940867..2940959) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" /label="yveF CDS" gene complement(2940867..2940959) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo /label="yveF gene" promotor_-10 complement(2940999..2941018) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2941016) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2941032..2941039) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2941090..2941773) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" /label="racX CDS" gene complement(2941090..2941773) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /label="racX gene" downshifts complement(2941108) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" /label="downshifts" CDS complement(2941789..2943144) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" /label="pbpE CDS" gene complement(2941789..2943144) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /label="pbpE gene" promotor_-10 complement(2943156..2943171) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2943172) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2943183..2943192) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2943446..2943453 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2943467..2943486 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2943470 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="upshifts" S_feature 2943492..2943682 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 2943683..2945104 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" /label="sacB CDS" gene 2943683..2945104 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /label="sacB gene" downshifts 2945098 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2945178..2946728 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" /label="levB CDS" gene 2945178..2946728 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /label="levB gene" promotor_-35 2946772..2946778 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2946792..2946803 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2946792 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="upshifts" CDS 2946836..2948398 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" /label="aspP CDS" gene 2946836..2948398 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /label="aspP gene" downshifts 2948376 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 2948388..2949077 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" /label="yvdT CDS" gene 2948388..2949077 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /label="yvdT gene" promotor_-35 2948427..2948434 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2948448..2948467 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2948457 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="upshifts" downshifts 2949058 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(2949156) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS 2949159..2949494 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" /label="psmA CDS" gene 2949159..2949494 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /label="psmA gene" CDS 2949494..2949814 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" /label="psmB CDS" gene 2949494..2949814 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /label="psmB gene" S_feature 2949815..2950005 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(2949850..2950362) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" /label="yvdQ CDS" gene complement(2949850..2950362) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /label="yvdQ gene" downshifts 2949982 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2950398..2950409) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2950404) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2950424..2950430) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2950477..2950613) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(2950520) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" CDS complement(2950614..2951957) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" /label="cotNP CDS" gene complement(2950614..2951957) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /label="cotNP gene" promotor_-10 complement(2951986..2952005) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2951994) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2952018..2952027) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2952019..2952024 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2952040..2952058 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2952043 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2952252..2952261 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2952270 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2952275..2952294 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2952313..2953275 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" /label="cotR CDS" gene 2952313..2953275 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /label="cotR gene" S_feature 2953276..2953529 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(2953556) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" tRNA complement(2953560..2953635) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnQ-Arg tRNA" gene complement(2953560..2953635) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /label="trnQ-Arg gene" promotor_-10 complement(2953662..2953681) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2953683) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2953697..2953700) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2953766..2953772 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2953782..2953857 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 2953782 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2953787..2953806 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2953834..2953841 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2953855..2953874 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2953859 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="upshifts" CDS 2953905..2954498 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" /label="clpP CDS" gene 2953905..2954498 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /label="clpP gene" downshifts 2954487 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 2954532..2954930 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(2954544..2955224) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" /label="mdxM CDS" gene complement(2954544..2955224) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /label="mdxM gene" downshifts complement(2954568) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" CDS complement(2955221..2956906) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" /label="mdxL CDS" gene complement(2955221..2956906) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /label="mdxL gene" CDS complement(2956899..2959172) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" /label="mdxK CDS" gene complement(2956899..2959172) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /label="mdxK gene" CDS complement(2959150..2960034) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" /label="mdxJ CDS" gene complement(2959150..2960034) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /label="mdxJ gene" CDS complement(2960040..2960876) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" /label="mdxG CDS" gene complement(2960040..2960876) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /label="mdxG gene" CDS complement(2960877..2962184) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" /label="mdxF CDS" gene complement(2960877..2962184) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /label="mdxF gene" promotor_-35 2961242..2961251 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2961264..2961283 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2961268 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2962224..2963477) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" /label="mdxE CDS" gene complement(2962224..2963477) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /label="mdxE gene" S_feature complement(2963478..2963572) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(2963573..2965342) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" /label="mdxD CDS" gene complement(2963573..2965342) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /label="mdxD gene" promotor_-35 2965263..2965268 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2965284..2965302 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2965294 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2965380..2965399) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2965393) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2965412..2965419) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2965455..2966405) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" /label="mdxR CDS" gene complement(2965455..2966405) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /label="mdxR gene" promotor_-10 complement(2966420..2966438) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2966433) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2966450..2966458) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2966539) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2966611..2967186) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" /label="yvdD CDS" gene complement(2966611..2967186) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /label="yvdD gene" downshifts complement(2966623) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2967229..2967248) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2967235..2967242 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2967245) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="upshifts" upshifts 2967252 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2967255..2967274 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2967263..2967270) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2967303..2967623 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" /label="yvdC CDS" gene 2967303..2967623 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /label="yvdC gene" downshifts 2967604 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2967650) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2967650..2969242) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" /label="yvdB CDS" gene complement(2967650..2969242) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /label="yvdB gene" CDS complement(2969261..2969854) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" /label="yvdA CDS" gene complement(2969261..2969854) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /label="yvdA gene" promotor_-10 complement(2969896..2969915) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2969909) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2969930..2969934) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2969980..2969985 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2970001..2970019 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2970002 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2970175..2970182 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2970196..2970215 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2970200 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" CDS 2970237..2971214 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" /label="yvcT CDS" gene 2970237..2971214 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /label="yvcT gene" downshifts 2971186 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2971252..2973192) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" /label="psdB CDS" gene complement(2971252..2973192) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /label="psdB gene" downshifts complement(2971276) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" /label="downshifts" CDS complement(2973167..2973946) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" /label="psdA CDS" gene complement(2973167..2973946) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /label="psdA gene" S_feature complement(2973947..2974028) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(2974029..2975099) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" /label="psdS CDS" gene complement(2974029..2975099) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /label="psdS gene" CDS complement(2975093..2975806) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" /label="psdR CDS" gene complement(2975093..2975806) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /label="psdR gene" promotor_-10 complement(2975852..2975871) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2975864) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2975866..2976127) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(2975884..2975887) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2975887..2975894 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2975905..2975924 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2975910 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2975953..2976162 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" /label="yvzJ CDS" gene 2975953..2976162 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /label="yvzJ gene" downshifts 2976140 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2976172) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2976198..2976962) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" /label="yvcN CDS" gene complement(2976198..2976962) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /label="yvcN gene" downshifts complement(2976220) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2976963..2977220) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" /label="crh CDS" gene complement(2976963..2977220) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /label="crh gene" CDS complement(2977244..2978194) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" /label="whiA CDS" gene complement(2977244..2978194) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /label="whiA gene" CDS complement(2978217..2979170) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" /label="mgfK CDS" gene complement(2978217..2979170) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /label="mgfK gene" CDS complement(2979172..2980059) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" /label="yvcJ CDS" gene complement(2979172..2980059) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /label="yvcJ gene" CDS complement(2980084..2980560) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" /label="yvcI CDS" gene complement(2980084..2980560) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /label="yvcI gene" promotor_-10 complement(2980580..2980599) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2980594) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2980615..2980619) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2980638..2980657) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2980651) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2980672..2980675) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2980727..2980877) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(2980770) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" /label="downshifts" CDS complement(2980878..2981828) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" /label="trxB CDS" gene complement(2980878..2981828) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /label="trxB gene" S_feature complement(2981829..2981916) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(2981905..2981924) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2981916) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2981918..2982009) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(2981939..2981942) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2981957..2981963 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2981977..2981995 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2981991 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="upshifts" S_feature 2981992..2985378 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(2982034..2983455) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" /label="cwlO CDS" gene complement(2982034..2983455) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /label="cwlO gene" downshifts complement(2982054) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" /label="downshifts" downshifts complement(2982178) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" misc_feature 2983082..2983086 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2983092 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2983371..2983375 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2983378 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2983456..2983653) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 2983576 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2983641..2983660) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(2983653) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" promotor_-35 complement(2983672..2983679) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(2983836..2985290) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" /label="yvcD CDS" gene complement(2983836..2985290) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /label="yvcD gene" downshifts complement(2983856) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" S_feature complement(2985291..2985415) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 2985336 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2985416..2987185) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" /label="bmrA CDS" gene complement(2985416..2987185) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /label="bmrA gene" S_feature complement(2987186..2987260) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(2987249..2987268) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2987260) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" CDS complement(2987350..2987709) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" /label="yvzA CDS" gene complement(2987350..2987709) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /label="yvzA gene" downshifts complement(2987370) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2987724..2989634) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" /label="yvcB CDS" gene complement(2987724..2989634) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /label="yvcB gene" CDS complement(2989636..2990361) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /translation="MKKIIFICFSLLLALTGGCSMNDNDKNSTNDNKTEAVKPKDMDP KDLPQVPAFQDEKTREYMVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGK NKESIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKK TDIYTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDE EKAKNKVEKLINSITFLIDKKEK*" /label="yvcA CDS" gene complement(2989636..2990361) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /label="yvcA gene" S_feature complement(2990362..2990450) /Source="Nicolas_S_feature" /locus_tag="new_3582691_3582779_c" /HighExp="T1.30H, T0.30H, T1.0H, T2.0H, T2.30H, T3.0H, T-1.40H, T-1.10H, MG 150, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1330" promotor_-10 complement(2990450..2990469) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2990450) /Source="Nicolas_upshifts" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2990452..2990581) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" promotor_-35 complement(2990485..2990488) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2990607..2991236) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" /label="hisIE CDS" gene complement(2990607..2991236) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /label="hisIE gene" downshifts complement(2990626) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" /label="downshifts" CDS complement(2991233..2991991) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" /label="hisF CDS" gene complement(2991233..2991991) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /label="hisF gene" CDS complement(2991988..2992725) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" /label="hisA CDS" gene complement(2991988..2992725) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /label="hisA gene" CDS complement(2992722..2993360) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" /label="hisH CDS" gene complement(2992722..2993360) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /label="hisH gene" promotor_no_box 2993218..2993318 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2993278 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2993361..2993945) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" /label="hisB CDS" gene complement(2993361..2993945) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /label="hisB gene" CDS complement(2993942..2995225) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" /label="hisD CDS" gene complement(2993942..2995225) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /label="hisD gene" CDS complement(2995222..2995863) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" /label="hisG CDS" gene complement(2995222..2995863) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /label="hisG gene" CDS complement(2995856..2997031) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " /label="hisZ CDS" gene complement(2995856..2997031) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /label="hisZ gene" S_feature complement(2997032..2997109) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 2997075..2997081 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2997093..2997112 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2997093..2997112) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2997106 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2997109) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2997125..2997132) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2997241..2997260 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2997248 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="upshifts" CDS 2997282..2998034 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" /label="yvpB CDS" gene 2997282..2998034 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /label="yvpB gene" S_feature 2998035..2998273 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(2998056..2998067) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2998062) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2998082..2998088) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2998274..2998939 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" /label="pelC CDS" gene 2998274..2998939 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /label="pelC gene" downshifts 2998910 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(2998959..2999477) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" /label="hprF CDS" gene complement(2998959..2999477) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /label="hprF gene" downshifts complement(2998993) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2999481..3000131) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" /label="ppaX CDS" gene complement(2999481..3000131) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /label="ppaX gene" CDS complement(3000128..3001066) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" /label="yvoD CDS" gene complement(3000128..3001066) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /label="yvoD gene" CDS complement(3001090..3001899) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" /label="lgt CDS" gene complement(3001090..3001899) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /label="lgt gene" CDS complement(3001913..3002845) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" /label="hprK CDS" gene complement(3001913..3002845) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /label="hprK gene" promotor_-10 complement(3002887..3002906) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3002893) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3002922..3002927) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3002962..3002969 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3002981 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3002984..3003001 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3003027..3004217 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" /label="nagA CDS" gene 3003027..3004217 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /label="nagA gene" promotor_-35 3004015..3004021 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3004036 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3004037..3004055 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3004214..3004942 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" /label="nagBA CDS" gene 3004214..3004942 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /label="nagBA gene" CDS 3004960..3005691 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" /label="nagR CDS" gene 3004960..3005691 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /label="nagR gene" CDS complement(3005711..3009580) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" /label="yvnB CDS" gene complement(3005711..3009580) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /label="yvnB gene" downshifts complement(3005833) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3009600..3009611) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3009607) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3009626..3009632) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3009670..3009676 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3009690..3009709 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3009695 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="upshifts" CDS 3009745..3010218 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" /label="yvnA CDS" gene 3009745..3010218 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /label="yvnA gene" S_feature 3010219..3010326 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(3010259..3011476) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" /label="cypX CDS" gene complement(3010259..3011476) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /label="cypX gene" downshifts complement(3010272) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3010298..3010303 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3010318..3010329 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3010328..3010613 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 3010328 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="upshifts" downshifts 3010570 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3011492..3012238) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" /label="pchC CDS" gene complement(3011492..3012238) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /label="pchC gene" S_feature complement(3012239..3012425) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(3012411..3012430) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3012425) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3012444..3012451) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3012559..3012566 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3012581..3012600 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3012593 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="upshifts" S_feature 3012594..3012663 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 3012664..3013173 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" /label="pchR CDS" gene 3012664..3013173 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /label="pchR gene" S_feature complement(3013069..3014407) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(3013110) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3013194..3014405 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" /label="pchE CDS" gene 3013194..3014405 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /label="pchE gene" downshifts 3014403 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" /label="downshifts" CDS complement(3014433..3014792) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" /label="yvlD CDS" gene complement(3014433..3014792) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /label="yvlD gene" S_feature 3014448..3015164 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(3014452) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3014794..3014991) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" /label="yvlC CDS" gene complement(3014794..3014991) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /label="yvlC gene" CDS complement(3014996..3016093) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" /label="yvlB CDS" gene complement(3014996..3016093) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /label="yvlB gene" CDS complement(3016118..3016444) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" /label="yvlA CDS" gene complement(3016118..3016444) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /label="yvlA gene" promotor_-10 complement(3016497..3016512) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3016512) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3016514..3017004) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(3016524..3016533) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3016592..3016595 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3016610..3016629 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3016620 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="upshifts" CDS 3016662..3016892 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" /label="yvkN CDS" gene 3016662..3016892 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /label="yvkN gene" promotor_-10 complement(3016995..3017014) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(3017005) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="upshifts" promotor_-35 complement(3017030..3017034) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(3017091..3017573) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" /label="yvzB CDS" gene complement(3017091..3017573) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo /label="yvzB gene" downshifts 3017099 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" /label="downshifts" downshifts complement(3017114) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3017246) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3017254..3017257) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3017334..3017338) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3017334) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3017354..3017357) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3017574..3017707) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(3017735..3020608) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" /label="uvrA CDS" gene complement(3017735..3020608) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /label="uvrA gene" downshifts complement(3017752) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3020616..3022601) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" /label="uvrB CDS" gene complement(3020616..3022601) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /label="uvrB gene" promotor_-10 complement(3022635..3022654) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3022647) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3022649..3022734) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(3022666..3022673) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3022779) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" /label="downshifts" CDS complement(3022787..3023017) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" /label="csbA CDS" gene complement(3022787..3023017) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /label="csbA gene" promotor_-10 complement(3023044..3023063) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(3023054) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="upshifts" S_feature complement(3023056..3023120) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(3023077..3023084) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(3023097..3023115) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3023118) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3023130..3023136) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3023186) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(3023212..3023312) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3023252) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3023334..3023341 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3023355..3023374 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3023372 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3023464..3025959 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" /label="yvkC CDS" gene 3023464..3025959 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /label="yvkC gene" misc_feature 3025974..3025978 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3025992 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="upshifts" CDS 3026035..3026604 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" /label="yvkB CDS" gene 3026035..3026604 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /label="yvkB gene" CDS 3026635..3027969 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" /label="yvkA CDS" gene 3026635..3027969 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /label="yvkA gene" downshifts 3027950 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" /label="downshifts" CDS complement(3028017..3029210) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" /label="minJ CDS" gene complement(3028017..3029210) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /label="minJ gene" downshifts complement(3028026) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" /label="downshifts" downshifts complement(3028091) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(3029211..3029288) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(3029214) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(3029289..3029627) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" /label="swrAAc CDS" gene complement(3029289..3029627) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo /label="swrAAc gene" CDS complement(3029602..3029718) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" /label="swrAAn CDS" gene complement(3029602..3029718) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo /label="swrAAn gene" S_feature complement(3029719..3029808) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(3029790..3029808) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3029808) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3029810..3029890) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(3029822..3029827) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3029876..3029894) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3029890) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3029908..3029915) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3030027..3031469) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" /label="ctpB CDS" gene complement(3030027..3031469) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /label="ctpB gene" downshifts complement(3030116) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3031515..3031526) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3031526) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3031541..3031547) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3031609..3032499) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" /label="ftsX CDS" gene complement(3031609..3032499) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /label="ftsX gene" downshifts complement(3031626) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" /label="downshifts" CDS complement(3032492..3033178) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" /label="ftsE CDS" gene complement(3032492..3033178) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /label="ftsE gene" S_feature complement(3033179..3033311) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(3033301..3033320) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3033311) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3033335..3033338) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3033412..3033750) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" /label="cccB CDS" gene complement(3033412..3033750) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /label="cccB gene" downshifts complement(3033413) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3033777..3033796) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3033790) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" CDS complement(3033799..3034683) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" /label="yvjA CDS" gene complement(3033799..3034683) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /label="yvjA gene" promotor_-35 complement(3033810..3033817) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(3034671..3034690) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3034692) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" promotor_-35 complement(3034705..3034712) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(3035840..3035911), complement(3034810..3035838)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" /label="prfB CDS" gene complement(3034810..3035911) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /label="prfB gene" downshifts complement(3034826) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(3035912..3035980) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(3035981..3038506) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" /label="secA CDS" gene complement(3035981..3038506) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /label="secA gene" S_feature complement(3038507..3038587) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(3038577..3038596) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3038587) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3038674..3039243) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" /label="hpf CDS" gene complement(3038674..3039243) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /label="hpf gene" downshifts complement(3038682) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 3039210..3039216 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3039229..3039248 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3039236 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3039270..3039288) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3039278) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3039280..>3039381) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(3039300..3039308) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 3039381..3039382 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_008" CDS complement(3039385..3039867) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" /label="flgN CDS" gene complement(3039385..3039867) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /label="flgN gene" CDS complement(3039883..3040149) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" /label="flgM CDS" gene complement(3039883..3040149) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /label="flgM gene" S_feature complement(3040150..3040229) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(3040230..3040649) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" /label="yvyF CDS" gene complement(3040230..3040649) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /label="yvyF gene" promotor_-10 complement(3040688..3040706) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3040699) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3040720..3040727) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3040723..3041445) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" /label="comFC CDS" gene complement(3040723..3041445) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /label="comFC gene" CDS complement(3041409..3041705) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" /label="comFB CDS" gene complement(3041409..3041705) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /label="comFB gene" promotor_-10 complement(3041731..3041750) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3041744) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3041761..3041768) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3041765..3043156) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" /label="comFA CDS" gene complement(3041765..3043156) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /label="comFA gene" promotor_-10 complement(3043170..3043189) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3043185) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3043203..3043210) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3043262..3044107) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" /label="fakBA CDS" gene complement(3043262..3044107) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /label="fakBA gene" downshifts complement(3043273) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3043524..3043531 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3043545..3043564 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3043555..3045287 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3043555 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3044134..3044153) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3044153) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3044168..3044171) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3044205..3044894) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" /label="degU CDS" gene complement(3044205..3044894) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /label="degU gene" downshifts complement(3044219) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature complement(3044895..3044976) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3044977..3046134) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" /label="degS CDS" gene complement(3044977..3046134) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /label="degS gene" S_feature complement(3046135..3046262) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3046182..3046185 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3046200..3046219 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3046211..3046297 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3046211 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3046256..3046275) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3046262) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3046279..3046287 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3046286..3046293) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3046299 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3046301..3046309 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3046351..3047004 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " /label="yvyE CDS" gene 3046351..3047004 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /label="yvyE gene" S_feature complement(3046707..3047299) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3047004..3048179 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " /label="tagV CDS" gene 3047004..3048179 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /label="tagV gene" promotor_-10 complement(3047295..3047313) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3047304) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3047327..3047333) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3048151 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(3048252..3049328) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" /label="tagO CDS" gene complement(3048252..3049328) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /label="tagO gene" downshifts complement(3048268) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3048314..3048323 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3048337..3048356 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3048345..3049578 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3048345 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3049329..3049411) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3049399..3049418) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3049411) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3049430..3049436) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3049473..3050666) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" /label="tuaH CDS" gene complement(3049473..3050666) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /label="tuaH gene" downshifts complement(3049503) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" /label="downshifts" CDS complement(3050695..3051453) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" /label="tuaG CDS" gene complement(3050695..3051453) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /label="tuaG gene" CDS complement(3051477..3052157) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" /label="tuaF CDS" gene complement(3051477..3052157) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /label="tuaF gene" CDS complement(3052186..3053652) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" /label="tuaE CDS" gene complement(3052186..3053652) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /label="tuaE gene" S_feature complement(3053653..3053736) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3053737..3055122) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" /label="tuaD CDS" gene complement(3053737..3055122) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /label="tuaD gene" CDS complement(3055184..3056353) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" /label="tuaC CDS" gene complement(3055184..3056353) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /label="tuaC gene" CDS complement(3056350..3057801) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" /label="tuaB CDS" gene complement(3056350..3057801) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /label="tuaB gene" CDS complement(3057857..3058006) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" /label="tuaAc CDS" gene complement(3057857..3058006) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo /label="tuaAc gene" CDS complement(3057951..3058490) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" /label="tuaAn CDS" gene complement(3057951..3058490) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo /label="tuaAn gene" misc_feature complement(3058546..3058563) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3058550) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3058717..3060207) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" /label="lytC CDS" gene complement(3058717..3060207) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /label="lytC gene" downshifts complement(3058739) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3060246..3062363) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" /label="lytB CDS" gene complement(3060246..3062363) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /label="lytB gene" CDS complement(3062387..3062695) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" /label="lytA CDS" gene complement(3062387..3062695) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /label="lytA gene" downshifts 3062601 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 3062691..3062695 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3062704..3062718 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3062705..3062723) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3062711 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3062737..3062744) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3062740) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3062761..3062769 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3062783..3062796 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3062801 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="upshifts" CDS 3062879..3063799 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" /label="tagU CDS" gene 3062879..3063799 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /label="tagU gene" downshifts 3063789 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3063839..3064981) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" /label="mnaA CDS" gene complement(3063839..3064981) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /label="mnaA gene" downshifts complement(3063863) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3065020..3065039) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3065034) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3065054..3065057) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3065110..3065114 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3065130..3065149 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3065131..3065226 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3065132 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="upshifts" CDS 3065227..3066105 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" /label="gtaB CDS" gene 3065227..3066105 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /label="gtaB gene" S_feature 3066106..3067197 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3066175..3066530) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3066439..3066657 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" /label="hypothetical protein CDS" gene 3066439..3066657 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /label="gene" CDS complement(3066531..3066614) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" /label="yvzH CDS" gene complement(3066531..3066614) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo /label="yvzH gene" S_feature complement(3066615..3066806) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3066807..3069509) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" /label="ggaB CDS" gene complement(3066807..3069509) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /label="ggaB gene" S_feature complement(3069510..3069632) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3069531..3069537 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3069552..3069570 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3069557..3072389 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3069557 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3069633..3070973) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" /label="ggaA CDS" gene complement(3069633..3070973) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo /label="ggaA gene" CDS complement(3071014..3071220) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" /label="yvzI CDS" gene complement(3071014..3071220) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo /label="yvzI gene" S_feature complement(3071221..3072094) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3072088..3072107) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3072094) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3072096..3072335) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3072120..3072126) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3072317..3072335) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3072335) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="upshifts" promotor_-35 complement(3072349..3072356) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3072358..3072365 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3072377..3072396 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3072391..3072521 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3072391 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3072463..3072563 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3072523 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS 3072527..3073123 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" /label="yvzE CDS" gene 3072527..3073123 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo /label="yvzE gene" downshifts 3072721 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3073162..3074745) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" /label="tagH CDS" gene complement(3073162..3074745) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /label="tagH gene" downshifts 3073205 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" /label="downshifts" CDS complement(3074765..3075592) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " /label="tagG CDS" gene complement(3074765..3075592) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /label="tagG gene" S_feature complement(3075593..3075657) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3075653..3075672) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3075657) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3075659..3075756) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3075688..3075691) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3075757..3077997) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" /label="tagF CDS" gene complement(3075757..3077997) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /label="tagF gene" CDS complement(3077997..3080018) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" /label="tagE CDS" gene complement(3077997..3080018) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /label="tagE gene" promotor_-35 3078760..3078769 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3078782..3078797 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3078793 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3080019..3080178) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3080179..3080568) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" /label="tagD CDS" gene complement(3080179..3080568) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /label="tagD gene" S_feature complement(3080569..3080703) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3080687..3080706) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3080703) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3080717..3080724) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3080858..3080864 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3080875..3080967 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3080875 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3080876..3080895 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3080968..3081738 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" /label="tagA CDS" gene 3080968..3081738 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /label="tagA gene" S_feature complement(3081095..3081443) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3081447..3081458) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3081451) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3081473..3081479) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3081763 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS 3081771..3082916 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" /label="tagB CDS" gene 3081771..3082916 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /label="tagB gene" downshifts 3082904 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" /label="downshifts" promotor_-35 3082958..3082965 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3082980..3082999 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3082990 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="upshifts" CDS 3083036..3084364 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" /label="tagC CDS" gene 3083036..3084364 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /label="tagC gene" downshifts 3084359 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3084420) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" SCAR 3084444..3084445 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_002" downshifts 3084468 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3084521..3085762) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" /label="pgdS CDS" gene complement(3084521..3085762) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /label="pgdS gene" downshifts complement(3084540) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3085784..3085802) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3085806) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3085815..3085822) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3085903..3086070) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" /label="edmS CDS" gene complement(3085903..3086070) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /label="edmS gene" downshifts complement(3085930) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" CDS complement(3086085..3087227) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" /label="capA CDS" gene complement(3086085..3087227) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /label="capA gene" CDS complement(3087246..3087695) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" /label="capC CDS" gene complement(3087246..3087695) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /label="capC gene" promotor_-35 3087389..3087395 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3087403 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="upshifts" promotor_-10 3087409..3087427 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3087416..3089625 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3087710..3088891) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" /label="capB CDS" gene complement(3087710..3088891) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /label="capB gene" promotor_-35 3089605..3089612 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3089627 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3089628..3089647 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3089648) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3089653..3089667) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3089675..3089679) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3089675..3090655 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" /label="rbsR CDS" gene 3089675..3090655 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /label="rbsR gene" promotor_-35 3090504..3090511 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3090525..3090544 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3090540 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" CDS 3090657..3091538 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" /label="rbsK CDS" gene 3090657..3091538 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /label="rbsK gene" CDS 3091535..3091930 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" /label="rbsD CDS" gene 3091535..3091930 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /label="rbsD gene" CDS 3091946..3093427 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" /label="rbsA CDS" gene 3091946..3093427 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /label="rbsA gene" CDS 3093429..3094397 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" /label="rbsC CDS" gene 3093429..3094397 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /label="rbsC gene" CDS 3094409..3095326 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" /label="rbsB CDS" gene 3094409..3095326 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /label="rbsB gene" promotor_-35 3095335..3095341 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3095356..3095374 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3095358 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="upshifts" CDS 3095408..3095944 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" /label="ywsB CDS" gene 3095408..3095944 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /label="ywsB gene" downshifts 3095927 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature 3095972..3096082 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3096051..3096057 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3096072..3096083 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3096084 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3096100..3096396 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" /label="ywsA CDS" gene 3096100..3096396 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /label="ywsA gene" S_feature 3096397..3097049 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3096436..3096963) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" /label="ywrO CDS" gene complement(3096436..3096963) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /label="ywrO gene" downshifts complement(3096446) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3096983..3097002) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3096996) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="upshifts" downshifts 3097007 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3097016..3097023) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3097062) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3097063..3097830) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" /label="alsD CDS" gene complement(3097063..3097830) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /label="alsD gene" CDS complement(3097892..3099604) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" /label="alsS CDS" gene complement(3097892..3099604) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /label="alsS gene" promotor_-35 3098503..3098512 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3098526..3098545 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3098526 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3099658..3099677) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3099663) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3099683..3099690 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3099692..3099696) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3099704..3099723 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3099714 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="upshifts" CDS 3099762..3100670 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" /label="alsR CDS" gene 3099762..3100670 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /label="alsR gene" promotor_-35 3100738..3100746 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3100748..3100880 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3100748 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3100760..3100779 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3100881..3102209 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" /label="ywrK CDS" gene 3100881..3102209 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /label="ywrK gene" downshifts 3102200 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3102266..3102943) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" /label="ywrJ CDS" gene complement(3102266..3102943) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /label="ywrJ gene" downshifts complement(3102276) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3103003..3104145) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" /label="cotB CDS" gene complement(3103003..3104145) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /label="cotB gene" promotor_-10 complement(3104182..3104201) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3104190) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3104192..3104272) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3104215..3104223) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3104273..3105361) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" /label="cotH CDS" gene complement(3104273..3105361) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /label="cotH gene" S_feature complement(3105362..3105475) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3105417..3105426 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3105439..3105458 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3105452 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3105475) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3105479..3105493) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3105502..3105506) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3105502..3106089 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" /label="cotG CDS" gene 3105502..3106089 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /label="cotG gene" CDS 3105590..3106069 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " /label="doubtful CDS (putative in frame frameshift)" gene 3105590..3106069 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /label="gene" S_feature complement(3105973..3106170) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3106006 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(3106016) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" /label="downshifts" downshifts 3106075 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts 3106154 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3106169..3106188) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3106175) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3106197..3106204 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3106201..3106210) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3106219..3106238 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3106225 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="upshifts" CDS 3106263..3106880 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" /label="ywrF CDS" gene 3106263..3106880 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /label="ywrF gene" S_feature 3106881..3106981 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3106938 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" /label="downshifts" promotor_-35 3107007..3107016 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3107028..3107043 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3107029 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3107058..3107393 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" /label="ywrE CDS" gene 3107058..3107393 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /label="ywrE gene" promotor_-10 complement(3107349..3107367) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3107358) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3107382..3107387) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3107392 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3107398..3108975) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" /label="hpxW CDS" gene complement(3107398..3108975) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /label="hpxW gene" S_feature 3107437..3109148 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3109126..3109133 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3109144..3109163 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3109150 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3109189..3109665 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" /label="chrS CDS" gene 3109189..3109665 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /label="chrS gene" CDS 3109679..3110272 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" /label="chrB CDS" gene 3109679..3110272 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /label="chrB gene" CDS 3110269..3110805 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" /label="chrA CDS" gene 3110269..3110805 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /label="chrA gene" downshifts 3110786 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(3110832..3111053) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" /label="ywqO CDS" gene complement(3110832..3111053) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /label="ywqO gene" upshifts 3111000 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3111007..3111008 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3111050..3111595) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" /label="ywqN CDS" gene complement(3111050..3111595) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /label="ywqN gene" promotor_-35 3111612..3111619 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3111634..3111653 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3111638 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="upshifts" CDS 3111718..3112599 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" /label="ywqM CDS" gene 3111718..3112599 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /label="ywqM gene" CDS complement(3112684..3113400) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" /label="nfi CDS" gene complement(3112684..3113400) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /label="nfi gene" downshifts complement(3112704) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3113410..3113874) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" /label="rttO CDS" gene complement(3113410..3113874) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /label="rttO gene" CDS complement(3113864..3115672) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" /label="rttN CDS" gene complement(3113864..3115672) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /label="rttN gene" CDS complement(3115691..3115951) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" /label="ywqI CDS" gene complement(3115691..3115951) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /label="ywqI gene" CDS complement(3115961..3116383) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" /label="ywqH CDS" gene complement(3115961..3116383) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /label="ywqH gene" S_feature complement(3116384..3116466) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3116458..3116477) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3116466) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3116490..3116497) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3116600..3116725) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" /label="hypothetical protein CDS" gene complement(3116600..3116725) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /label="gene" S_feature complement(3116643..3116774) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3116686) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3116775..3117560) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" /label="ywqG CDS" gene complement(3116775..3117560) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /label="ywqG gene" S_feature complement(3117561..3117676) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3117669..3117688) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3117676) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3117702..3117709) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3117752..3119074) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" /label="uglF CDS" gene complement(3117752..3119074) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /label="uglF gene" downshifts complement(3117764) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3119108) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3119110..3119235) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3119110..3119128) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3119144..3119149) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3119215..3119234) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3119235) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3119269..3120033) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" /label="ptpZ CDS" gene complement(3119269..3120033) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /label="ptpZ gene" downshifts complement(3120052) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(3120086..3120799) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" /label="ptkA CDS" gene complement(3120086..3120799) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /label="ptkA gene" downshifts complement(3120103) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" /label="downshifts" CDS complement(3120789..3121535) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" /label="tkmA CDS" gene complement(3120789..3121535) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /label="tkmA gene" promotor_-10 complement(3121567..3121586) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3121579) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3121603..3121606) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3121769..3121912) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" /label="ywzD CDS" gene complement(3121769..3121912) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /label="ywzD gene" downshifts complement(3121790) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3121913..3121998) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3121988..3121999) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3121998) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3122000..3122230) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3122037..3122041 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3122057..3122076 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3122066 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="upshifts" CDS 3122116..3123726 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" /label="ywqB CDS" gene 3122116..3123726 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /label="ywqB gene" promotor_-10 complement(3122218..3122236) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3122230) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3122232..3122406) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3122250..3122257) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3122393..3122412) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3122406) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3122426..3122434) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3123713..3126481 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" /label="hepA CDS" gene 3123713..3126481 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /label="hepA gene" downshifts complement(3126530) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3126607..3127464) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" /label="ywpJ CDS" gene complement(3126607..3127464) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /label="ywpJ gene" CDS complement(3127470..3128246) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" /label="glcR CDS" gene complement(3127470..3128246) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /label="glcR gene" promotor_-10 complement(3128272..3128291) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3128294) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3128296..3128368) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3128306..3128313) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3128370..3128469) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3128413) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(3128470..3128811) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" /label="ssbB CDS" gene complement(3128470..3128811) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /label="ssbB gene" promotor_-10 complement(3128833..3128852) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3128852) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3128866..3128873) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3128888..3129271) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" /label="ywpG CDS" gene complement(3128888..3129271) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /label="ywpG gene" promotor_-10 complement(3129293..3129312) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3129300..3129319 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3129304 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3129313) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="upshifts" promotor_-35 complement(3129327..3129334) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3129394..3129413 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3129397 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3129446) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS 3129446..3129856 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" /label="ywpF CDS" gene 3129446..3129856 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /label="ywpF gene" S_feature 3129857..3129940 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3129898 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3129996..3130304) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" /label="ywpE CDS" gene complement(3129996..3130304) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /label="ywpE gene" downshifts complement(3129997) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS 3130648..3131484 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" /label="ywpD CDS" gene 3130648..3131484 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /label="ywpD gene" promotor_-35 3130864..3130871 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3130886..3130905 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3130889 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3131483 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" /label="downshifts" CDS complement(3131531..3131923) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" /label="mscL CDS" gene complement(3131531..3131923) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /label="mscL gene" downshifts complement(3131537) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3131996..3132421) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" /label="fabZ CDS" gene complement(3131996..3132421) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /label="fabZ gene" promotor_-10 complement(3132482..3132501) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3132498) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3132500..3132584) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3132516..3132523) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3132563 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3132566..3132585 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3132576..3132595) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3132584) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="upshifts" S_feature complement(3132586..3133670) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3132609..3132614) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3132613..3133677 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" /label="rapD CDS" gene 3132613..3133677 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /label="rapD gene" S_feature 3133678..3134562 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3133700..3134509) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" /label="flhP CDS" gene complement(3133700..3134509) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /label="flhP gene" downshifts complement(3133715) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3134543..3135355) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" /label="flhO CDS" gene complement(3134543..3135355) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /label="flhO gene" S_feature complement(3135356..3135435) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3135386..3135393 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3135407..3135426 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3135416 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3135429..3135447) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3135435) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="upshifts" promotor_-35 complement(3135461..3135468) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3135518..3136519) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " /label="mbl CDS" gene complement(3135518..3136519) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /label="mbl gene" downshifts complement(3135524) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" misc_feature complement(3136574..3136593) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3136598) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="upshifts" S_feature complement(3136600..3136684) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3136685..3136966) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" /label="spoIIID CDS" gene complement(3136685..3136966) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /label="spoIIID gene" CDS complement(3136981..3137091) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" /label="usd CDS" gene complement(3136981..3137091) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /label="usd gene" promotor_-10 complement(3137122..3137140) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3137144) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3137156..3137161) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3137237..3137243 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3137257..3137276 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3137273 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="upshifts" CDS 3137316..3137729 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" /label="ywoH CDS" gene 3137316..3137729 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /label="ywoH gene" CDS 3137751..3138941 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" /label="ywoG CDS" gene 3137751..3138941 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /label="ywoG gene" CDS complement(3139032..3140438) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" /label="ywoF CDS" gene complement(3139032..3140438) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /label="ywoF gene" downshifts complement(3139329) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3140471..3140490) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3140489) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3140505..3140508) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3140544..3142016) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" /label="pucI CDS" gene complement(3140544..3142016) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /label="pucI gene" CDS complement(3142197..3143555) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" /label="ywoD CDS" gene complement(3142197..3143555) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /label="ywoD gene" downshifts complement(3142211) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3143555..3144124) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" /label="ywoC CDS" gene complement(3143555..3144124) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /label="ywoC gene" promotor_-10 complement(3144143..3144154) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3144161) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3144168..3144174) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3144231..3144398) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" /label="hypothetical protein CDS" gene complement(3144231..3144398) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo /label="gene" CDS complement(3144308..3144772) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" /label="ywoB CDS" gene complement(3144308..3144772) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /label="ywoB gene" promotor_-10 complement(3144802..3144821) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3144807) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3144835..3144842) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3144973..3144976 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3144991..3145010 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3144995 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3145054..3146268 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" /label="amtB CDS" gene 3145054..3146268 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /label="amtB gene" promotor_-10 complement(3145884..3145902) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3145885) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3145916..3145923) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3146134..3146140 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3146154..3146173 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3146156 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3146280..3146630 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" /label="glnK CDS" gene 3146280..3146630 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /label="glnK gene" downshifts 3146623 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3146682..3146690 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3146704..3146712 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3146711 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3146753..3146762 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3146775..3146790 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3146779 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" CDS 3146811..3147392 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" /label="bcrC CDS" gene 3146811..3147392 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /label="bcrC gene" promotor_-10 complement(3146909..3146928) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3146919) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3146942..3146950) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3147373 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(3147433..3147855) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" /label="ywnJ CDS" gene complement(3147433..3147855) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /label="ywnJ gene" downshifts complement(3147452) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3147890..3147905) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3147909) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3147918..3147927) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3147966..3148817) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" /label="spoIIQ CDS" gene complement(3147966..3148817) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /label="spoIIQ gene" downshifts complement(3147975) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts complement(3148217) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" promotor_-35 3148454..3148456 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3148473..3148492 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3148474..3148820 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3148474 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3148812..3148815 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3148822..3148957 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3148822 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3148851) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3148857..3148866) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3148958..3149449 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" /label="ywnH CDS" gene 3148958..3149449 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /label="ywnH gene" promotor_-35 3149187..3149192 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3149208..3149226 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3149219 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3149310..3150218) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3149446..3149964 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" /label="ywnG CDS" gene 3149446..3149964 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /label="ywnG gene" downshifts 3149769 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 3149967 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3150123..3150254 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " /label="hypothetical protein CDS" gene 3150123..3150254 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /label="gene" CDS complement(3150251..3150685) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" /label="ywnF CDS" gene complement(3150251..3150685) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /label="ywnF gene" downshifts complement(3150263) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3150734..3150753) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3150741) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3150743..3151040) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3150768..3150775) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3150814..3150818 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3150835..3150854 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3150847..3150927 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3150848 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3150928..3152376 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" /label="clsA CDS" gene 3150928..3152376 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /label="clsA gene" upshifts complement(3151040) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3151041..3151059) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3151042..3151385) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3151075..3151081) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3151363..3151381) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3151385) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3151397..3151402) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3152365 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3152397..3153170) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" /label="mta CDS" gene complement(3152397..3153170) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /label="mta gene" downshifts complement(3152419) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" promotor_-35 3153245..3153248 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3153264..3153283 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3153268 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="upshifts" CDS 3153315..3153698 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" /label="ywnC CDS" gene 3153315..3153698 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /label="ywnC gene" downshifts 3153685 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3153733..3154374) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" /label="ywnB CDS" gene complement(3153733..3154374) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /label="ywnB gene" downshifts complement(3153783) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3154442..3154843) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" /label="ywnA CDS" gene complement(3154442..3154843) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /label="ywnA gene" promotor_-10 complement(3154892..3154911) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3154902) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3154904..3154977) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3154926..3154931) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3154978..3156687) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" /label="ureC CDS" gene complement(3154978..3156687) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /label="ureC gene" CDS complement(3156684..3157058) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" /label="ureB CDS" gene complement(3156684..3157058) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /label="ureB gene" CDS complement(3157055..3157372) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" /label="ureA CDS" gene complement(3157055..3157372) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /label="ureA gene" S_feature complement(3157373..3157457) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3157457) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3157459..3157472) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3157459..3157552) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3157553..3157717) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" /label="ywzE CDS" gene complement(3157553..3157717) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /label="ywzE gene" promotor_-10 complement(3157640..3157658) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3157652) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="upshifts" promotor_-35 complement(3157670..3157678) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3157718..3157889) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3157890..3158072) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" /label="ywzF CDS" gene complement(3157890..3158072) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo /label="ywzF gene" S_feature complement(3158073..3158219) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3158207..3158226) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3158219) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" S_feature complement(3158221..3158335) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3158241..3158248) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" Polymorphism join(3158322,3158324) /Source="geneious" /ID="SNP_BsDelta6_3770059_3770058" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)8 -> (A)9" /Codon_Change /Coverage=64 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="2.1e-197" /Variant_Raw_Frequency=61 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 3158349 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3158352..3158356 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3158369..3158557) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" /label="csbD CDS" gene complement(3158369..3158557) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /label="csbD gene" downshifts complement(3158380) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" /label="downshifts" downshifts 3158547 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3158583..3158601) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3158594) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3158615..3158621) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3158630..3159130) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" /label="ywmF CDS" gene complement(3158630..3159130) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /label="ywmF gene" promotor_-10 complement(3159166..3159185) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3159173) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3159199..3159205) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3159265..3160398) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" /label="rapB CDS" gene complement(3159265..3160398) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /label="rapB gene" downshifts complement(3159283) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3160425..3160444) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3160432) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3160495..3160513) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3160511) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3160527..3160534) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3160590..3161615) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" /label="moaA CDS" gene complement(3160590..3161615) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /label="moaA gene" downshifts complement(3160603) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3161631..3162419) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" /label="fdhD CDS" gene complement(3161631..3162419) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /label="fdhD gene" promotor_-10 complement(3162445..3162464) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3162451) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3162453..3162664) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3162478..3162485) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3162665..3162826) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" /label="ywmE CDS" gene complement(3162665..3162826) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /label="ywmE gene" promotor_-10 complement(3162839..3162857) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3162859) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="upshifts" promotor_-35 complement(3162871..3162877) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3162920..3163594) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" /label="ywmD CDS" gene complement(3162920..3163594) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /label="ywmD gene" downshifts complement(3162935) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3163647..3163787) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" /label="hypothetical protein CDS" gene complement(3163647..3163787) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /label="gene" CDS complement(3163918..3164601) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" /label="ywmC CDS" gene complement(3163918..3164601) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /label="ywmC gene" promotor_-35 3164978..3164982 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3164987..3166018) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" /label="spoIID CDS" gene complement(3164987..3166018) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /label="spoIID gene" promotor_-10 3164997..3165016 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3165003) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3165015 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3166046..3166064) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3166059) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3166061..3166178) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3166080..3166085) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3166120..3166125 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3166137..3168797 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3166137 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3166141..3166159 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3166214..3167524) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" /label="murAA CDS" gene complement(3166214..3167524) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /label="murAA gene" downshifts complement(3166223) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3167548..3167567) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3167555) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3167558..3168298) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" /label="ywmB CDS" gene complement(3167558..3168298) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /label="ywmB gene" promotor_-35 complement(3167581..3167590) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3167929) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3167931..3167939) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3167953..3167961) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3168053..3168068) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3168061) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3168081..3168090) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3168299..3168426) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3168427..3168657) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" /label="ywzB CDS" gene complement(3168427..3168657) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /label="ywzB gene" S_feature complement(3168658..3168920) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3168793..3168812 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3168799 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="upshifts" CDS 3168827..3169300 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" /label="ywmA CDS" gene 3168827..3169300 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /label="ywmA gene" promotor_-10 complement(3168904..3168923) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3168920) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="upshifts" S_feature complement(3168922..3169305) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3168938..3168941) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3169334..3169732) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" /label="atpC CDS" gene complement(3169334..3169732) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /label="atpC gene" downshifts complement(3169350) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3169724..3169742) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3169733) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3169756..3169762) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3169756..3171177) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" /label="atpD CDS" gene complement(3169756..3171177) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /label="atpD gene" CDS complement(3171203..3172066) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" /label="atpG CDS" gene complement(3171203..3172066) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /label="atpG gene" S_feature complement(3172067..3172142) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3172143..3173651) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" /label="atpA CDS" gene complement(3172143..3173651) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /label="atpA gene" CDS complement(3173668..3174213) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" /label="atpH CDS" gene complement(3173668..3174213) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /label="atpH gene" CDS complement(3174210..3174722) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" /label="atpF CDS" gene complement(3174210..3174722) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /label="atpF gene" S_feature complement(3174723..3174884) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3174885..3175097) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" /label="atpE CDS" gene complement(3174885..3175097) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /label="atpE gene" CDS complement(3175143..3175877) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" /label="atpB CDS" gene complement(3175143..3175877) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /label="atpB gene" promotor_no_box 3175691..3175791 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3175751 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3175885..3176268) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" /label="atpI CDS" gene complement(3175885..3176268) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /label="atpI gene" misc_feature complement(3175957..3175975) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3175959) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3176269..3176539) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3176501..3176510 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3176510 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3176515..3176534) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3176524..3176543 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3176539) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3176541..3176662) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3176547..3176554) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3176691..3177320) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" /label="upp CDS" gene complement(3176691..3177320) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /label="upp gene" downshifts complement(3176707) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3177364..3177383) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3177387) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" promotor_-35 complement(3177398..3177405) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3177455..3178702) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" /label="glyA CDS" gene complement(3177455..3178702) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /label="glyA gene" downshifts complement(3177478) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3178744..3178763) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3178761) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3178763..3178847) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3178778..3178783) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3178892) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" /label="downshifts" CDS complement(3178909..3179451) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" /label="ywlG CDS" gene complement(3178909..3179451) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /label="ywlG gene" CDS complement(3179464..3179913) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" /label="rpiB CDS" gene complement(3179464..3179913) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /label="rpiB gene" S_feature complement(3179914..3180013) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3180005..3180024) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3180013) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="upshifts" promotor_-35 complement(3180038..3180045) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3180070..3180522) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" /label="prpB CDS" gene complement(3180070..3180522) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /label="prpB gene" promotor_-10 complement(3180539..3180558) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3180557) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="upshifts" promotor_-35 complement(3180573..3180576) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3180598..3181155) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" /label="mntP CDS" gene complement(3180598..3181155) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /label="mntP gene" promotor_-10 complement(3181182..3181200) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3181195) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="upshifts" promotor_-35 complement(3181216..3181221) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3181234..3182274) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" /label="tsaC CDS" gene complement(3181234..3182274) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /label="tsaC gene" downshifts complement(3181239) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3182275..3182339) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3182329..3182348) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3182339) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3182341..3182430) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3182364..3182368) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3182431..3182874) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" /label="ywlB CDS" gene complement(3182431..3182874) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /label="ywlB gene" CDS complement(3182941..3183615) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" /label="spoIIR CDS" gene complement(3182941..3183615) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /label="spoIIR gene" promotor_-10 complement(3183377..3183395) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3183384) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3183410..3183416) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3183647..3183664) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3183648) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3183680..3183685) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3183721 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3183725..3183744 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3183756..3184118 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" /label="ywlA CDS" gene 3183756..3184118 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /label="ywlA gene" downshifts complement(3184131) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3184135..3184422) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" /label="ywkF CDS" gene complement(3184135..3184422) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /label="ywkF gene" S_feature complement(3184423..3184481) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3184479..3184498) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3184482..3185348) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" /label="prmC CDS" gene complement(3184482..3185348) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /label="prmC gene" upshifts complement(3184495) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3184511..3184520) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3185350..3186420) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" /label="prfA CDS" gene complement(3185350..3186420) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /label="prfA gene" downshifts complement(3185353) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" downshifts 3186421 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3186448..3186467) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3186472) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3186474..3186585) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3186481..3186487) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3186517..3186536 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3186531 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3186546..3186932 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" /label="ywkD CDS" gene 3186546..3186932 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /label="ywkD gene" promotor_-10 complement(3186567..3186585) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3186585) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="upshifts" promotor_-35 complement(3186599..3186606) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3187000..3187008 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3187019..3187037 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3187020 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3187054..3187608 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" /label="racA CDS" gene 3187054..3187608 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /label="racA gene" misc_feature 3187538..3187542 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3187543 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3187587 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3187642..3188601) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" /label="ywkB CDS" gene complement(3187642..3188601) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /label="ywkB gene" downshifts complement(3187664) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3188639..3188657) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3188653) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3188672..3188678) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3188683..3190431) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" /label="maeA CDS" gene complement(3188683..3190431) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /label="maeA gene" promotor_-10 complement(3189157..3189175) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3189165) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3189190..3189196) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3190432..3190522) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3190506..3190525) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3190522) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3190539..3190546) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3190665) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(3190670..3191257) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" /label="tdk CDS" gene complement(3190670..3191257) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /label="tdk gene" CDS complement(3191346..3191546) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" /label="rpmEA CDS" gene complement(3191346..3191546) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /label="rpmEA gene" downshifts complement(3191359) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3191547..3191624) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3191620..3191639) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3191624) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3191653..3191660) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3191665..3192948) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" /label="rho CDS" gene complement(3191665..3192948) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /label="rho gene" S_feature complement(3192949..3193251) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3192979..3193140) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" /label="hypothetical protein CDS" gene complement(3192979..3193140) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /label="gene" promotor_-10 complement(3193231..3193250) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3193251) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3193266..3193270) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3193355..3194320) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" /label="glpX CDS" gene complement(3193355..3194320) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /label="glpX gene" downshifts complement(3193361) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 3193937..3193946 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3193959..3193978 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3193967 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3194351..3195640) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" /label="murAB CDS" gene complement(3194351..3195640) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /label="murAB gene" S_feature complement(3195641..3196000) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3196019..3196657) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" /label="tal CDS" gene complement(3196019..3196657) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /label="tal gene" downshifts complement(3196045) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" S_feature complement(3196658..3196776) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3196777..3197634) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" /label="fbaA CDS" gene complement(3196777..3197634) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /label="fbaA gene" S_feature complement(3197635..3197761) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3197743..3197762) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3197761) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="upshifts" promotor_-35 complement(3197776..3197783) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3197815..3198189) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" /label="spo0F CDS" gene complement(3197815..3198189) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /label="spo0F gene" promotor_-10 complement(3198229..3198247) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3198243) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="upshifts" S_feature complement(3198245..3198884) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3198246..3198249 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3198258..3198266) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3198265..3198284 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3198278 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3198292..3198297 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3198313..3198332 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3198323 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" CDS 3198355..3198876 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" /label="ywjG CDS" gene 3198355..3198876 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /label="ywjG gene" promotor_-35 3198819..3198822 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3198837..3198856 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3198851 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3198874..3198893) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3198884) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="upshifts" downshifts 3198895 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3198908..3198915) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3198958..3200565) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" /label="pyrG CDS" gene complement(3198958..3200565) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /label="pyrG gene" downshifts complement(3198971) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3200566..3200753) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3200741..3200760) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3200753) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3200775..3200782) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3200807..3201328) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" /label="rpoE CDS" gene complement(3200807..3201328) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /label="rpoE gene" downshifts complement(3200863) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" S_feature complement(3201329..3201431) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3201412..3201431) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3201431) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3201433..3201510) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3201447..3201450) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3201511..3202650) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" /label="acdA CDS" gene complement(3201511..3202650) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /label="acdA gene" CDS complement(3202647..3204764) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" /label="fadF CDS" gene complement(3202647..3204764) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /label="fadF gene" S_feature complement(3204765..3204823) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3204824..3204843) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3204837) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3204857..3204864) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3204863..3204869 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3204883..3204894 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3204888 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="upshifts" CDS 3204919..3206115 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" /label="clsB CDS" gene 3204919..3206115 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /label="clsB gene" S_feature complement(3205111..3205989) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3205979..3205997) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3205990) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3206013..3206018) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3206128..3207090 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" /label="uvsE CDS" gene 3206128..3207090 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /label="uvsE gene" promotor_-35 3207104..3207110 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3207125..3207143 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3207125 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="upshifts" CDS 3207171..3207443 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" /label="ywjC CDS" gene 3207171..3207443 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /label="ywjC gene" downshifts complement(3207177) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 3207433 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" /label="downshifts" S_feature 3207478..3207884 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3207485..3208009) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" /label="ywjB CDS" gene complement(3207485..3208009) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /label="ywjB gene" downshifts complement(3207507) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3208019..3209746) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" /label="ywjA CDS" gene complement(3208019..3209746) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /label="ywjA gene" promotor_-10 complement(3209780..3209799) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3209794) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3209813..3209819) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3209835..3211337) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" /label="clsC CDS" gene complement(3209835..3211337) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /label="clsC gene" promotor_-10 complement(3211361..3211379) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3211379) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3211394..3211400) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3211424..3211796) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3211467) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3211823..3212494) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" /label="narI CDS" gene complement(3211823..3212494) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /label="narI gene" downshifts complement(3211841) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(3212491..3213045) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" /label="narJ CDS" gene complement(3212491..3213045) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /label="narJ gene" CDS complement(3213071..3214534) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" /label="narH CDS" gene complement(3213071..3214534) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /label="narH gene" CDS complement(3214524..3218210) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" /label="narG CDS" gene complement(3214524..3218210) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /label="narG gene" misc_feature complement(3218241..3218260) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3218265) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3218267..3218396) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3218406..3218882) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" /label="arfM CDS" gene complement(3218406..3218882) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /label="arfM gene" downshifts complement(3218441) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3218905..3218924) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3218917) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="upshifts" promotor_-35 complement(3218939..3218942) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3218989 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3218992..3219011 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3219026..3219745 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" /label="ywiC CDS" gene 3219026..3219745 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /label="ywiC gene" downshifts 3219729 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3219777..3220493) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" /label="fnr CDS" gene complement(3219777..3220493) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /label="fnr gene" downshifts complement(3219779) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" /label="downshifts" downshifts complement(3219849) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" misc_feature complement(3220519..3220538) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3220531) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3220592..3221779) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" /label="narK CDS" gene complement(3220592..3221779) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /label="narK gene" misc_feature complement(3221809..3221828) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3221827) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3221915..3223585) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" /label="argS CDS" gene complement(3221915..3223585) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /label="argS gene" downshifts complement(3221917) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3223582..3224010) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" /label="ywiB CDS" gene complement(3223582..3224010) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /label="ywiB gene" misc_feature 3224078..3224092 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3224078..3224097) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3224085 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3224094) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3224114..3224117) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3224149..3224168) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3224161) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="upshifts" SCAR join(3224190,3224197) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs09" N_region 3224191..3224196 /note="SacI site (GAGCTC)" /created_by="User" /modified_by="User" /label="IIG_Bs09" S_feature <3224197..3226675 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3224198..3225574) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" /label="ywhL CDS" gene complement(3224198..3225574) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /label="ywhL gene" CDS complement(3225613..3226968) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" /label="ywhK CDS" gene complement(3225613..3226968) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /label="ywhK gene" promotor_-10 complement(3227004..3227023) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3227022) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3227036..3227045) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3227148..3227167 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3227149 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3227194) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" /label="downshifts" CDS 3227198..3228343 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" /label="rapF CDS" gene 3227198..3228343 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /label="rapF gene" promotor_-35 3228202..3228206 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3228223..3228242 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3228230 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3228313) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 3228327..3228446 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" /label="phrF CDS" gene 3228327..3228446 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /label="phrF gene" downshifts 3228431 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" S_feature 3228476..3228544 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3228545..3229018 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" /label="ywhH CDS" gene 3228545..3229018 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /label="ywhH gene" downshifts 3229007 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3229050..3229922) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" /label="speB CDS" gene complement(3229050..3229922) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /label="speB gene" downshifts complement(3229061) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3229127) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(3229983..3230813) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" /label="speE CDS" gene complement(3229983..3230813) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /label="speE gene" S_feature complement(3230814..3230909) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3230897..3230916) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3230908) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3230929..3230936) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3230954..3230959 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3230975..3230993 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3230977 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="upshifts" CDS 3231015..3233090 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" /label="pbpG CDS" gene 3231015..3233090 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /label="pbpG gene" downshifts complement(3233143) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(3233267..3233382) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3233310) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" /label="downshifts" CDS complement(3233383..3233901) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" /label="ywhD CDS" gene complement(3233383..3233901) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /label="ywhD gene" CDS complement(3233915..3234574) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" /label="ywhC CDS" gene complement(3233915..3234574) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /label="ywhC gene" promotor_-35 3234597..3234600 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3234610..3234629) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3234615..3234634 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3234618 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3234628) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3234630..3234913) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3234644..3234651) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3234683..3234871 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" /label="hmtB CDS" gene 3234683..3234871 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /label="hmtB gene" downshifts 3234860 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3234914..3235333) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" /label="ywhA CDS" gene complement(3234914..3235333) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /label="ywhA gene" promotor_-10 complement(3235383..3235402) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3235394) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3235417..3235424) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3235453..3237369) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" /label="thrZ CDS" gene complement(3235453..3237369) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /label="thrZ gene" promotor_-10 complement(3236647..3236665) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3236652) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3236682..3236686) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3237400) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3237423..3237644) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTB RNA" gene complement(3237423..3237644) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /label="tboTB gene" misc_RNA complement(3237676..3237897) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTA RNA" gene complement(3237676..3237897) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /label="tboTA gene" S_feature complement(3237929..3238191) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3237940 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" /label="downshifts" downshifts complement(3237972) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3237979..3238134) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" /label="hypothetical protein CDS" gene complement(3237979..3238134) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /label="gene" promotor_-35 3238141..3238144 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3238153..3238166 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3238160 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3238168..3238187) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3238191) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3238201..3238207) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3238214..3239614) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" /label="mmr CDS" gene complement(3238214..3239614) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /label="mmr gene" CDS complement(3239614..3240084) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" /label="ywgB CDS" gene complement(3239614..3240084) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /label="ywgB gene" downshifts complement(3240040) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3240196..3240696) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" /label="ywgA CDS" gene complement(3240196..3240696) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /label="ywgA gene" downshifts complement(3240199) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" /label="downshifts" CDS complement(3240732..3242033) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" /label="ywfO CDS" gene complement(3240732..3242033) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /label="ywfO gene" promotor_-10 complement(3242057..3242076) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3242071) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3242073..3242194) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3242092..3242094) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3242195..3242419) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" /label="ywzC CDS" gene complement(3242195..3242419) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /label="ywzC gene" S_feature complement(3242420..3242504) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3242493..3242512) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3242503) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3242527..3242530) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3242570..3242576 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3242591..3242602 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3242592 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="upshifts" CDS 3242634..3243410 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" /label="psrF CDS" gene 3242634..3243410 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /label="psrF gene" downshifts 3243396 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" /label="downshifts" promotor_-35 3243498..3243505 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3243520..3243539 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3243524..3247750 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3243524 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3243554..3244444) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" /label="ywfM CDS" gene complement(3243554..3244444) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /label="ywfM gene" promotor_no_box complement(3244444..3244544) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3244484) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3244612..3245457) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" /label="lipL CDS" gene complement(3244612..3245457) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /label="lipL gene" downshifts complement(3244775) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" /label="downshifts" CDS complement(3245506..3246405) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" /label="cysL CDS" gene complement(3245506..3246405) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /label="cysL gene" promotor_-10 complement(3246448..3246467) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3246451) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3246481..3246488) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3246552) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3246552..3247523) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" /label="pta CDS" gene complement(3246552..3247523) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /label="pta gene" promotor_-10 complement(3247558..3247577) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3247583) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3247593..3247597) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3247671..3247682) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3247674) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3247696..3247702) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3247745..3247764 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3247752 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3247793..3248557 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" /label="hemQ CDS" gene 3247793..3248557 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /label="hemQ gene" downshifts 3248544 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR join(3248564,3248571) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs11" N_region 3248565..3248570 /note="SacI site (GAGCTC)" /created_by="User" /label="IIG_Bs11" S_feature <3248571..3248623 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" CDS complement(3248573..3249811) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" /label="ywfA CDS" gene complement(3248573..3249811) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /label="ywfA gene" promotor_-10 complement(3249853..3249872) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3249865) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3249884..3249891) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3250021..3251433) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" /label="rocC CDS" gene complement(3250021..3251433) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /label="rocC gene" downshifts complement(3250028) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3251433..3253133) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" /label="rocB CDS" gene complement(3251433..3253133) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /label="rocB gene" misc_feature complement(3252102..3252118) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3252114) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3253207..3254754) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" /label="rocA CDS" gene complement(3253207..3254754) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /label="rocA gene" downshifts complement(3253214) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3254798) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3254800..3254980) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3254801..3254819) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3254981..3256255) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" /label="rocG CDS" gene complement(3254981..3256255) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /label="rocG gene" S_feature complement(3256256..3256338) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3256338) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3256351..3256369) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3256431) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" /label="downshifts" CDS complement(3256432..3256896) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" /label="bslB CDS" gene complement(3256432..3256896) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /label="bslB gene" S_feature complement(3256897..3257007) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3256989..3257008) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3257007) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="upshifts" promotor_-35 complement(3257023..3257030) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3257218) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3257220..3257675) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" /label="spsL CDS" gene complement(3257220..3257675) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /label="spsL gene" misc_feature 3257310..3257329 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3257318 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3257668..3258519) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" /label="spsK CDS" gene complement(3257668..3258519) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /label="spsK gene" CDS complement(3258533..3259480) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" /label="spsJ CDS" gene complement(3258533..3259480) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /label="spsJ gene" CDS complement(3259480..3260220) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" /label="spsI CDS" gene complement(3259480..3260220) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /label="spsI gene" promotor_-35 3260238..3260243 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3260244 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3260245..3261264) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" /label="spsG CDS" gene complement(3260245..3261264) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /label="spsG gene" promotor_-10 3260258..3260276 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3261128..3261137 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3261150..3261165 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3261161 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3261267..3261989) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" /label="spsF CDS" gene complement(3261267..3261989) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /label="spsF gene" CDS complement(3261982..3263103) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" /label="spsE CDS" gene complement(3261982..3263103) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /label="spsE gene" CDS complement(3263103..3263972) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" /label="spsD CDS" gene complement(3263103..3263972) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /label="spsD gene" CDS complement(3263973..3265142) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" /label="spsC CDS" gene complement(3263973..3265142) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /label="spsC gene" CDS complement(3265163..3266587) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" /label="spsB CDS" gene complement(3265163..3266587) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /label="spsB gene" CDS complement(3266592..3267362) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" /label="spsA CDS" gene complement(3266592..3267362) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /label="spsA gene" promotor_-10 complement(3267397..3267416) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3267411) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3267430..3267439) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3267530..3267535 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3267551..3267569 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3267553..3267681 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3267553 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="upshifts" CDS 3267682..3268227 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" /label="gerQ CDS" gene 3267682..3268227 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /label="gerQ gene" downshifts 3268213 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3268271..3268642) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" /label="ywdK CDS" gene complement(3268271..3268642) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /label="ywdK gene" downshifts complement(3268289) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3268704..3270026) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" /label="ywdJ CDS" gene complement(3268704..3270026) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /label="ywdJ gene" CDS complement(3270046..3270363) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" /label="ywdI CDS" gene complement(3270046..3270363) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /label="ywdI gene" promotor_-10 complement(3270392..3270411) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3270403) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3270425..3270431) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3270466..3270473 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3270489..3270508 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3270492 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="upshifts" CDS 3270531..3271901 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" /label="ywdH CDS" gene 3270531..3271901 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /label="ywdH gene" CDS complement(3271926..3272603) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" /label="ung CDS" gene complement(3271926..3272603) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /label="ung gene" downshifts complement(3271940) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3272430..3272449) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3272446) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3272465..3272470) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3272617..3273423) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" /label="ywdF CDS" gene complement(3272617..3273423) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /label="ywdF gene" promotor_-10 complement(3272916..3272934) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3272930) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3272949..3272955) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3273452..3273471) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3273458) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3273487..3273494) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3273513..3274046) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" /label="ywdE CDS" gene complement(3273513..3274046) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /label="ywdE gene" CDS complement(3274094..3274729) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" /label="ywdD CDS" gene complement(3274094..3274729) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /label="ywdD gene" CDS complement(3274722..3275060) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" /label="ywzG CDS" gene complement(3274722..3275060) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /label="ywzG gene" promotor_-10 complement(3275082..3275101) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3275093) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3275116..3275123) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3275144..3275147 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3275162..3275181 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3275162 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="upshifts" CDS 3275204..3276019 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" /label="pdxK CDS" gene 3275204..3276019 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /label="pdxK gene" downshifts 3275998 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3276074) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3276109..3276357) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" /label="ywdA CDS" gene complement(3276109..3276357) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /label="ywdA gene" downshifts complement(3276129) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" /label="downshifts" upshifts complement(3276375) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3276377..3276450) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3276385..3276391) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3276451..3277890) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" /label="sacA CDS" gene complement(3276451..3277890) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /label="sacA gene" CDS complement(3277887..3279272) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" /label="sacP CDS" gene complement(3277887..3279272) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /label="sacP gene" misc_feature complement(3279291..3279300) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3279305) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3279307..3279371) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3279350..3279367) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3279371) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3279383..3279390) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3279413..3279432) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3279431) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3279446..3279453) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3279512..3279515 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3279522 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3279530..3279549 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3279574..3280344 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" /label="nirC CDS" gene 3279574..3280344 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /label="nirC gene" S_feature 3280345..3281412 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3280383..3281213) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" /label="sacT CDS" gene complement(3280383..3281213) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /label="sacT gene" downshifts complement(3280384) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3281239..3281258) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3281245) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3281253..3281555) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" /label="ywcI CDS" gene complement(3281253..3281555) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /label="ywcI gene" promotor_-35 complement(3281273..3281280) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3281556..3281694) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3281679..3281698) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3281694) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3282009..3282017 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3282028..3282046 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3282029 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="upshifts" CDS 3282085..3282162 /gene="vpr" /old_locus_tag="BSU_38090" /created_by="User" /modified_by="User" /transl_table=11 /locus_tag="PG10_BSU_38090-3'_ext" /translation="MKKGISQQTPPAISDTIGAYLQNDA*" /label="PG10_BSU_38090-3'_ext" gene 3282085..3282162 /gene="vpr_3'-chimera" /old_locus_tag="BSU_38090" /created_by="User" /locus_tag="PG10_BSU_38090-3'_ext" /label="PG10_BSU_38090-3'_ext" SCAR 3282095..3282096 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_017" CDS complement(3282098..3283099) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " /label="ywcH CDS" gene complement(3282098..3283099) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /label="ywcH gene" S_feature complement(3283100..3283261) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3283273..3284022) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" /label="nfrAA CDS" gene complement(3283273..3284022) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /label="nfrAA gene" downshifts complement(3283306) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3284040..3284059) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3284057) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3284074..3284077) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3284128..3285309) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" /label="rodA CDS" gene complement(3284128..3285309) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /label="rodA gene" downshifts complement(3284142) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3285310..3285441) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3285435..3285450) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3285441) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="upshifts" promotor_-35 complement(3285462..3285471) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3285676..3285683 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3285694..3285804 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3285694..3285713 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3285694 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="upshifts" CDS 3285805..3286068 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" /label="ywcE CDS" gene 3285805..3286068 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /label="ywcE gene" downshifts 3285958 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3286074 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3286111..3286485) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" /label="qoxD CDS" gene complement(3286111..3286485) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /label="qoxD gene" downshifts complement(3286122) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3286487..3287101) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" /label="qoxC CDS" gene complement(3286487..3287101) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /label="qoxC gene" CDS complement(3287115..3289064) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" /label="qoxB CDS" gene complement(3287115..3289064) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /label="qoxB gene" misc_feature 3288328..3288347 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3288334 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3288758..3288858 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3288818 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3288928 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" CDS complement(3289092..3290057) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" /label="qoxA CDS" gene complement(3289092..3290057) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /label="qoxA gene" S_feature complement(3290058..3290126) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3290113..3290132) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3290126) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3290128..3290313) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3290145..3290149) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3290244..3290249 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3290265..3290283 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3290270 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3290304..3290323) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3290313) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3290315..3290424) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3290338..3290342) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3290380 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3290409..3290428) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3290424) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3290444..3290448) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3290502..3290520) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3290507..3290513 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3290519) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3290528..3290546 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3290531 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3290536..3290541) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3290573..3290818 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" /label="ywzA CDS" gene 3290573..3290818 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /label="ywzA gene" downshifts 3290800 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3290889..3292430) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" /label="galT CDS" gene complement(3290889..3292430) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /label="galT gene" downshifts complement(3290918) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3292434..3293606) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" /label="galK CDS" gene complement(3292434..3293606) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /label="galK gene" promotor_-10 complement(3293624..3293642) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3293646) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3293657..3293663) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3293687..3294070) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" /label="ywcD CDS" gene complement(3293687..3294070) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /label="ywcD gene" CDS complement(3294088..3294759) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" /label="slrC CDS" gene complement(3294088..3294759) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /label="slrC gene" promotor_-10 complement(3294781..3294800) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3294790) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3294816..3294819) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3294900..3294903 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3294918..3294937 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3294927..3295114 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3294927 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="upshifts" CDS 3295115..3295273 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" /label="slrA CDS" gene 3295115..3295273 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /label="slrA gene" S_feature 3295274..3295658 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3295639..3295644 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3295660..3295678 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3295660 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="upshifts" CDS 3295716..3296024 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" /label="vbfB CDS" gene 3295716..3296024 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /label="vbfB gene" downshifts complement(3295802) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3295806..3295906) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3295846) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3296021..3297562 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" /label="vbfA CDS" gene 3296021..3297562 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /label="vbfA gene" downshifts 3297553 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3297593..3298195) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" /label="ywbO CDS" gene complement(3297593..3298195) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /label="ywbO gene" downshifts complement(3297607) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3298196..3298477) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3298478..3299728) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" /label="efeB CDS" gene complement(3298478..3299728) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /label="efeB gene" downshifts complement(3298574) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" /label="downshifts" CDS complement(3299747..3300904) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" /label="efeM CDS" gene complement(3299747..3300904) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /label="efeM gene" misc_feature complement(3299820..3299839) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3299847) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3300901..3302346) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" /label="efeU CDS" gene complement(3300901..3302346) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /label="efeU gene" promotor_-10 complement(3302380..3302399) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3302390) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3302413..3302420) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3302503..3303171) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" /label="thiE CDS" gene complement(3302503..3303171) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /label="thiE gene" downshifts complement(3302512) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3303168..3303986) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" /label="thiM CDS" gene complement(3303168..3303986) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /label="thiM gene" CDS complement(3303994..3304899) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" /label="cidR CDS" gene complement(3303994..3304899) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /label="cidR gene" misc_feature complement(3304634..3304653) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3304645) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3304940..3304959) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3304950..3304957 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3304961) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" upshifts 3304969 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3304971..3304990 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3304975..3304982) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3305005..3305391 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" /label="cidA CDS" gene 3305005..3305391 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /label="cidA gene" CDS 3305373..3306050 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" /label="cidB CDS" gene 3305373..3306050 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /label="cidB gene" downshifts 3306022 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3306094..3306101 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3306112 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3306115..3306134 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3306154..3307353 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" /label="ywbF CDS" gene 3306154..3307353 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /label="ywbF gene" CDS 3307387..3307584 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" /label="ywbE CDS" gene 3307387..3307584 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /label="ywbE gene" downshifts 3307563 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(3307619..3308809) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" /label="rlmI CDS" gene complement(3307619..3308809) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /label="rlmI gene" downshifts complement(3307634) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" /label="downshifts" downshifts complement(3307718) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" misc_feature complement(3308833..3308852) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3308849) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3308869..3308876 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3308885 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3308890..3308909 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3308930..3309310 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" /label="glxA CDS" gene 3308930..3309310 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /label="glxA gene" downshifts 3309208 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" /label="downshifts" downshifts 3309279 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" CDS complement(3309348..3310025) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391717.1" /db_xref="EnsemblGenomes-Gn:BSU38380" /db_xref="EnsemblGenomes-Tr:CAB15864" /db_xref="InterPro:IPR024250" /db_xref="SubtiList:BG10563" /db_xref="UniProtKB/Swiss-Prot:P39585" /translation="MLDYIWLDDESPILQQVPVEYSSAALIFSPFIQMPEGWENAKRK NDYEHIYPNDNEIRGIGKAVSWKKVMSSCGFQTHAELALALMTSIGALRDEFAREDLA EVLHENINGDLYYPSEDHISNFHIPSLVKVLGANGSNRFYYAEPIVENRGVLDITEAN LRTVLDEAATELVLTDEKMDFVFMSVYDSFINVFLAKDKNIHELVERMGWEAMICDES TYISWYR*" /label="ywbB CDS" gene complement(3309348..3310025) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /label="ywbB gene" downshifts complement(3309355) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3310034..3310053) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3310059) /Source="Nicolas_upshifts" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3310065..3310071) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3310102..3311436) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8990303, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cellobiose phosphotransferase system enzyme IIC permease component" /protein_id="NP_391718.1" /db_xref="EnsemblGenomes-Gn:BSU38390" /db_xref="EnsemblGenomes-Tr:CAB15865" /db_xref="GOA:P39584" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG10562" /db_xref="UniProtKB/Swiss-Prot:P39584" /translation="MSTFTRVMEEKIMPVAGKIAGQRHLSALRDGIILTMPLIIIGSV FLILTSLPIPGYADFMASVFGNEWADKLGYPVNASFDIMAMIAAFGIAYRLAESYGVD ALSAGAISIAAFLLATPFEVPFTPHGSTESIMVGGGIPITLLGSKGLFVAMLIALFST EIYRYIIQKNIVFKMPDGVPPAVSKSFVALIPGFIIVLLVWLARLLIEMTPFQSLHNV VGDLLGTPLSILGGSLGGSLIAEFVQMLLWSCGIHGASIIGGIMAPIWYGAMDANRLA FQAGEALPSIFTTQFFQIWINVGGSGATLALVLTMLVRSRSKQMKQLGRLGIGPALFN INEPIIFGMPIVMNPLLIVPFIIAPLLTITATYIGMSTGLVARPAGIAVPWTMPPLIS GYLATGGKVSGAVMQLVNLLITCAIYYPFFRIWDHQKWREESAVESGDKNVM*" /label="ywbA CDS" gene complement(3310102..3311436) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /label="ywbA gene" misc_feature complement(3311484..3311502) /Source="Nicolas_upshift_promotors" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3311507) /Source="Nicolas_upshifts" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3311601..3311608 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3311613 /Source="Nicolas_upshifts" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3311622..3311640 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3311664..3313601 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391719.1" /db_xref="EnsemblGenomes-Gn:BSU38400" /db_xref="EnsemblGenomes-Tr:CAB15866" /db_xref="GOA:P16396" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10561" /db_xref="UniProtKB/Swiss-Prot:P16396" /translation="MKNMSCKLVVSVTLFFSFLTIGPLAHAQNSSEKEVIVVYKNKAG KETILDSDADVEQQYKHLPAVAVTADQETVKELKQDPDILYVENNVSFTAADSTDFKV LSDGTDTSDNFEQWNLEPIQVKQAWKAGLTGKNIKIAVIDSGISPHDDLSIAGGYSAV SYTSSYKDDNGHGTHVAGIIGAKHNGYGIDGIAPEAQIYAVKALDQNGSGDLQSLLQG IDWSIANRMDIVNMSLGTTSDSKILHDAVNKAYEQGVLLVAASGNDGNGKPVNYPAAY SSVVAVSATNEKNQLASFSTTGDEVEFSAPGTNITSTYLNQYYATGSGTSQATPHAAA MFALLKQRDPAETNVQLREEMRKNIVDLGTAGRDQQFGYGLIQYKAQATDSAYAAAEQ AVKKAEQTKAQIDINKARELISQLPNSDAKTALHKRLDKVQSYRNVKDAKDKVAKAEK YKTQQTVDTAQTAINKLPNGTDKKNLQKRLDQVKRYIASKQAKDKVAKAEKSKKKTDV DSAQSAIGKLPASSEKTSLQKRLNKVKSTNLKTAQQSVSAAEKKSTDANAAKAQSAVN QLQAGKDKTALQKRLDKVKKKVAAAEAKKVETAKAKVKKAEKDKTKKSKTSAQSAVNQ LKASNEKTKLQKRLNAVKPKK*" /label="epr CDS" gene 3311664..3313601 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /label="epr gene" promotor_-10 complement(3312808..3312827) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3312809) /Source="Nicolas_upshifts" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3312841..3312849) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3313591 /Source="Nicolas_upshifts" /id="D1990" /incds=0 /nref=175 /ntot=224 /MaxReadThrough="1.26567" /MaxDrop="6.00181" /score="15.6173594" /energy="-13" /TU="NA" /idTUdmin="U3021" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3313704..3313711 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3313726..3313745 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3313745 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3313957..3313964 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3313977..3313996 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3313977 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="upshifts" CDS 3314029..3315408 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" /label="sacX CDS" gene 3314029..3315408 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /label="sacX gene" S_feature complement(3315117..3316320) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3315462..3316304 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" /label="sacY CDS" gene 3315462..3316304 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /label="sacY gene" CDS complement(3316355..3317215) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" /label="gspA CDS" gene complement(3316355..3317215) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /label="gspA gene" downshifts complement(3316365) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" /label="downshifts" downshifts 3317199 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3317237..3317255) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3317255) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3317270..3317276) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3317325..3318038) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" /label="ywaF CDS" gene complement(3317325..3318038) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /label="ywaF gene" promotor_-35 3317440..3317441 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3317461..3317478 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3317463 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3318066..3318077) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3318067) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3318092..3318098) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3318113..3318119 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3318134..3318153 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3318144 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 3318189..3318704 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" /label="tyrZR CDS" gene 3318189..3318704 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /label="tyrZR gene" misc_RNA 3318705..3318911 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboYB RNA" gene 3318705..3318911 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /label="tboYB gene" downshifts 3318871 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3318953..3320194 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" /label="tyrZ CDS" gene 3318953..3320194 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /label="tyrZ gene" promotor_-35 3320285..3320293 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3320304..3320322 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3320315 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="upshifts" CDS 3320350..3321717 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" /label="eapD CDS" gene 3320350..3321717 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /label="eapD gene" downshifts 3321694 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(3321747..3322379) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" /label="relQ CDS" gene complement(3321747..3322379) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /label="relQ gene" downshifts complement(3321765) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3322415..3322430) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3322423) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3322443..3322451) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3322521..3323456) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" /label="menA CDS" gene complement(3322521..3323456) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /label="menA gene" downshifts complement(3322533) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3323200..3323209 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3323223..3323242 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3323227 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3323457..3323544) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3323527..3323546) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3323544) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3323562..3323566) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3323589..3323601) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3323589) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3323616..3323622) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3323619..3323753) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" /label="hypothetical protein CDS" gene complement(3323619..3323753) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /label="gene" promotor_-35 3323700..3323707 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3323721..3323740 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3323730 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="upshifts" S_feature 3323733..3323837 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3323832..3323841 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3323839 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3323853..3323868 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3323875) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3323877..3323891) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3323903..3324052 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" /label="ywzH CDS" gene 3323903..3324052 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /label="ywzH gene" CDS 3324070..3325581 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" /label="dltA CDS" gene 3324070..3325581 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /label="dltA gene" CDS 3325578..3326765 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" /label="dltB CDS" gene 3325578..3326765 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /label="dltB gene" CDS 3326782..3327018 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" /label="dltC CDS" gene 3326782..3327018 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /label="dltC gene" CDS 3327018..3328196 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" /label="dltD CDS" gene 3327018..3328196 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /label="dltD gene" S_feature 3328197..3328286 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3328287..3329045 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" /label="dltE CDS" gene 3328287..3329045 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /label="dltE gene" downshifts 3329013 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature complement(3329047..3330274) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3329093..3329100 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3329114..3329133 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3329127 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="upshifts" CDS 3329186..3330277 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" /label="ilvK CDS" gene 3329186..3330277 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /label="ilvK gene" downshifts 3330179 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 3330267 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3330311..3331639) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" /label="licH CDS" gene complement(3330311..3331639) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /label="licH gene" downshifts complement(3330319) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" CDS complement(3331636..3331968) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" /label="licA CDS" gene complement(3331636..3331968) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /label="licA gene" CDS complement(3331987..3333345) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" /label="licC CDS" gene complement(3331987..3333345) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /label="licC gene" CDS complement(3333361..3333669) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" /label="licB CDS" gene complement(3333361..3333669) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /label="licB gene" promotor_-10 complement(3333714..3333733) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3333730) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3333747..3333753) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3333798) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3333798..3335723) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" /label="licR CDS" gene complement(3333798..3335723) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /label="licR gene" promotor_-35 3334461..3334470 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3334484..3334503 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3334492 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3335796..3335813) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3335820) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="upshifts" promotor_-35 complement(3335828..3335835) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3335886..3336044) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" /label="yxzF CDS" gene complement(3335886..3336044) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /label="yxzF gene" downshifts complement(3335913) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3336073..3336663) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" /label="aag CDS" gene complement(3336073..3336663) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /label="aag gene" promotor_-10 complement(3336691..3336709) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3336702) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3336723..3336729) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3336732..3336738 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3336754..3336772 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3336757 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="upshifts" CDS 3336792..3338435 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" /label="katX CDS" gene 3336792..3338435 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /label="katX gene" S_feature complement(3336929..3338478) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3338430 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3338480..3338571) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3338482..3338488 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3338496 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3338503..3338522 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3338523) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" /label="downshifts" CDS 3338540..3339742 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" /label="yxlH CDS" gene 3338540..3339742 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /label="yxlH gene" S_feature complement(3338573..3339738) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3338616) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS complement(3339739..3340515) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" /label="yxlG CDS" gene complement(3339739..3340515) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /label="yxlG gene" CDS complement(3340512..3341399) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" /label="yxlF CDS" gene complement(3340512..3341399) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /label="yxlF gene" CDS complement(3341406..3341594) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" /label="yxlE CDS" gene complement(3341406..3341594) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /label="yxlE gene" CDS complement(3341591..3341797) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" /label="yxlD CDS" gene complement(3341591..3341797) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /label="yxlD gene" CDS complement(3341794..3342114) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" /label="yxlC CDS" gene complement(3341794..3342114) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /label="yxlC gene" promotor_-35 3341927..3341936 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3341949..3341968 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3341951 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3342107..3342643) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" /label="sigY CDS" gene complement(3342107..3342643) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /label="sigY gene" upshifts complement(3342671) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3342672..3342687) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3342699..3342708) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3342774..3342781 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3342795..3342814 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3342804 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="upshifts" CDS 3342855..3344228 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" /label="yxlA CDS" gene 3342855..3344228 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /label="yxlA gene" S_feature complement(3343135..3343677) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3343665..3343684) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3343677) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3343699..3343706) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3344063 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3344243..3345073) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" /label="nnrA CDS" gene complement(3344243..3345073) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /label="nnrA gene" downshifts complement(3344249) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3345092..3345110) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3345107) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3345125..3345131) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3345151) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3345153..3345172) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3345159..3346886) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" /label="cydD CDS" gene complement(3345159..3346886) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /label="cydD gene" downshifts complement(3345258) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" /label="downshifts" CDS complement(3346883..3348586) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" /label="cydC CDS" gene complement(3346883..3348586) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /label="cydC gene" CDS complement(3348586..3349602) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" /label="cydB CDS" gene complement(3348586..3349602) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /label="cydB gene" promotor_-10 complement(3349476..3349494) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3349485) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3349510..3349515) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3349586..3350992) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" /label="cydA CDS" gene complement(3349586..3350992) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /label="cydA gene" S_feature complement(3350993..3351201) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3351184..3351203) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3351201) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3351203..3351311) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3351217..3351222) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3351308..3351327) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3351323) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="upshifts" promotor_-35 complement(3351341..3351348) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3351469..3351476 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3351486 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3351491..3351509 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3351548..3352900 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" /label="cimH CDS" gene 3351548..3352900 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /label="cimH gene" S_feature complement(3352499..3354981) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3352885 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3352976..3352995 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3352982 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="upshifts" CDS 3353022..3354710 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" /label="yxkI CDS" gene 3353022..3354710 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /label="yxkI gene" promotor_-35 3354708..3354717 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3354729..3354744 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3354733 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="upshifts" CDS 3354768..3354968 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" /label="yxzE CDS" gene 3354768..3354968 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /label="yxzE gene" S_feature 3354969..3355913 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3354982..3355821) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" /label="yxkH CDS" gene complement(3354982..3355821) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /label="yxkH gene" promotor_-10 complement(3355847..3355865) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3355865) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3355878..3355885) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3355880 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(3355928..3357025) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" /label="msmX CDS" gene complement(3355928..3357025) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /label="msmX gene" downshifts complement(3355929) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3357058..3357077) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3357075) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3357077..3357145) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3357090..3357097) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3357146..3358039) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" /label="yxkF CDS" gene complement(3357146..3358039) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /label="yxkF gene" promotor_-10 complement(3358066..3358085) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3358085) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3358099..3358106) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3358113..3358118 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3358134..3358152 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3358143 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3358160..3358166 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3358181..3358199 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3358187 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="upshifts" CDS 3358223..3359680 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" /label="aldY CDS" gene 3358223..3359680 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /label="aldY gene" promotor_-10 complement(3359106..3359124) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3359121) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3359139..3359144) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3359661 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 3359705 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3359722..3360558) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" /label="gdnE CDS" gene complement(3359722..3360558) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /label="gdnE gene" downshifts complement(3359740) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" misc_RNA complement(3360635..3360737) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" /label="gdwB RNA" gene complement(3360635..3360737) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /label="gdwB gene" downshifts complement(3360661) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3360763..3360782) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3360774) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3360776..3361517) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3360796..3360802) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3360854..3360861 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3360874..3360892 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3360883 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" S_feature 3360893..3360978 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3360954..3360961 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3360975..3360994 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3360980 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" CDS 3361126..3361668 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" /label="yxkC CDS" gene 3361126..3361668 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /label="yxkC gene" promotor_-10 complement(3361493..3361512) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3361517) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3361526..3361535) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3361658 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" S_feature 3361703..3362025 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3361743..3362762) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" /label="galE CDS" gene complement(3361743..3362762) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /label="galE gene" downshifts complement(3361761) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3362788..3362807) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3362802) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3362822..3362825) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3362877..3363383) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" /label="yxkA CDS" gene complement(3362877..3363383) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /label="yxkA gene" promotor_-10 complement(3363389..3363408) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3363411) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3363413..3363416 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3363422..3363428) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3363431..3363450 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3363434 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="upshifts" CDS 3363513..3364388 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" /label="yxjO CDS" gene 3363513..3364388 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /label="yxjO gene" S_feature complement(3363763..3363851) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3363785) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3363811..3363911) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3363851) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="upshifts" CDS 3364466..3364939 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" /label="yxjN CDS" gene 3364466..3364939 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /label="yxjN gene" CDS 3364957..3366177 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" /label="yxjM CDS" gene 3364957..3366177 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /label="yxjM gene" CDS 3366164..3366820 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" /label="yxjL CDS" gene 3366164..3366820 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /label="yxjL gene" promotor_-35 3366818..3366823 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3366837..3366856 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3366840 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="upshifts" CDS 3366870..3368102 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" /label="pepT CDS" gene 3366870..3368102 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /label="pepT gene" downshifts complement(3366887) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" downshifts 3368087 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 3368148..3368157 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3368170..3368185 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3368172..3368394 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3368172 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3368351 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 3368405..3368411 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3368424..3368524 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3368424 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="upshifts" promotor_-10 3368426..3368444 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3368503..3368510 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3368524..3368542 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3368526..3368623 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3368526 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" CDS 3368624..3368887 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" /label="yxjJ CDS" gene 3368624..3368887 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /label="yxjJ gene" promotor_-35 3368651..3368654 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3368669..3368688 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3368681 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3368835 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3368879 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 3368954..3368963 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3368969 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3368975..3368990 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3369016..3369504 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" /label="yxjI CDS" gene 3369016..3369504 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /label="yxjI gene" promotor_-35 3369509..3369516 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3369530..3369549 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3369540 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3369570..3369676 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswI RNA" gene 3369570..3369676 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /label="mswI gene" downshifts 3369671 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3369759..3370892 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" /label="yxjH CDS" gene 3369759..3370892 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /label="yxjH gene" S_feature complement(3370032..3370275) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3370270..3370289) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3370279) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3370304..3370311) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3370898..3370905 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3370920..3370939 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3370926 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3370961..3371067 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswJ RNA" gene 3370961..3371067 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /label="mswJ gene" downshifts 3371014 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 3371068..3371144 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3371145..3372281 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" /label="yxjG CDS" gene 3371145..3372281 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /label="yxjG gene" downshifts 3372268 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3372334..3373107) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" /label="yxjF CDS" gene complement(3372334..3373107) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /label="yxjF gene" downshifts complement(3372344) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3373124..3373774) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" /label="scoB CDS" gene complement(3373124..3373774) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /label="scoB gene" CDS complement(3373771..3374487) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" /label="scoA CDS" gene complement(3373771..3374487) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /label="scoA gene" CDS complement(3374511..3375929) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" /label="yxjC CDS" gene complement(3374511..3375929) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /label="yxjC gene" promotor_-10 complement(3375097..3375115) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3375116) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3375131..3375136) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3375930..3376014) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3375998..3376016) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3376014) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3376032..3376037) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3376083..3376931) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" /label="rlmA CDS" gene complement(3376083..3376931) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /label="rlmA gene" downshifts complement(3376093) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(3376932..3377117) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3377106..3377125) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3377117) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3377119..3377844) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3377141..3377145) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3377279..3377286 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3377299..3377318 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3377308 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3377318..3377420 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswB RNA" gene 3377318..3377420 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /label="gswB gene" S_feature 3377421..3377524 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3377496..3377502 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3377516..3377527 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3377526 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="upshifts" CDS 3377547..3378740 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" /label="nupG CDS" gene 3377547..3378740 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /label="nupG gene" promotor_-10 complement(3377831..3377849) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3377847) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3377862..3377869) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3378516 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3378736 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3378782..3379210) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" /label="yxiTc CDS" gene complement(3378782..3379210) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo /label="yxiTc gene" CDS complement(3379211..3379453) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" /label="yxiTn CDS" gene complement(3379211..3379453) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo /label="yxiTn gene" S_feature complement(3379454..3379517) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3379506..3379521) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3379517) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3379533..3379542) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3379550 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(3379598..3379888) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" /label="yxiS CDS" gene complement(3379598..3379888) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /label="yxiS gene" downshifts complement(3379604) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3379913..3379932) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3379930) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3379938..3381998) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" /label="katE CDS" gene complement(3379938..3381998) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /label="katE gene" promotor_-35 complement(3379946..3379953) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3382027..3382045) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3382031) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3382060..3382066) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3382091..3382096 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3382110 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3382112..3382130 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3382124..3382198 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3382199..3383479 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" /label="citH CDS" gene 3382199..3383479 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /label="citH gene" S_feature 3383480..3383619 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3383576 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3383637..3384365) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" /label="bglS CDS" gene complement(3383637..3384365) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /label="bglS gene" downshifts complement(3383654) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3384396..3384415) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3384407) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3384429..3384436) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3384553..3384660) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3384596) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" /label="downshifts" CDS complement(3384661..3385494) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" /label="licT CDS" gene complement(3384661..3385494) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /label="licT gene" promotor_-10 complement(3385525..3385544) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3385544) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3385558..3385565) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3385590..3386270) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" /label="yxiP CDS" gene complement(3385590..3386270) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /label="yxiP gene" promotor_-10 complement(3386317..3386336) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3386326) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="upshifts" promotor_-35 complement(3386350..3386357) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3386418..3386421 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3386436..3386455 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3386436 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="upshifts" CDS 3386477..3387763 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" /label="yxiO CDS" gene 3386477..3387763 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /label="yxiO gene" promotor_-10 complement(3387208..3387226) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3387216) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3387240..3387247) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3387734 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3387782..3389221) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" /label="deaD CDS" gene complement(3387782..3389221) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /label="deaD gene" downshifts complement(3387805) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" /label="downshifts" misc_feature complement(3389245..3389264) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3389262) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3389303..3390451) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" /label="yxiM CDS" gene complement(3389303..3390451) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /label="yxiM gene" promotor_-10 complement(3390478..3390494) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3390494) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3390496..3390580) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3390509..3390514) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3390581..3390769) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" /label="yxzI CDS" gene complement(3390581..3390769) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo /label="yxzI gene" CDS complement(3390800..3390931) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " /label="yxzJ CDS" gene complement(3390800..3390931) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /label="yxzJ gene" CDS complement(3390943..3391404) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" /label="yxiK CDS" gene complement(3390943..3391404) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /label="yxiK gene" CDS complement(3391420..3391716) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" /label="yxiJ CDS" gene complement(3391420..3391716) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /label="yxiJ gene" CDS complement(3391744..3392232) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" /label="yxiI CDS" gene complement(3391744..3392232) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /label="yxiI gene" CDS complement(3392250..3392702) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" /label="yxzG CDS" gene complement(3392250..3392702) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /label="yxzG gene" S_feature complement(3392703..3392771) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3392772..3393101) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" /label="yxiH CDS" gene complement(3392772..3393101) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /label="yxiH gene" S_feature complement(3393102..3393223) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3393224..3393640) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" /label="yxiG CDS" gene complement(3393224..3393640) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /label="yxiG gene" CDS complement(3393691..3394059) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" /label="yxzC CDS" gene complement(3393691..3394059) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /label="yxzC gene" CDS complement(3394053..3394523) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" /label="yxiF CDS" gene complement(3394053..3394523) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /label="yxiF gene" S_feature complement(3394524..3394848) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3394849..3395277) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" /label="wapI CDS" gene complement(3394849..3395277) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /label="wapI gene" CDS complement(3395339..3402343) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" /label="wapA CDS" gene complement(3395339..3402343) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /label="wapA gene" misc_feature 3402350..3402364 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3402364 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3402374..3402393) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3402389) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3402408..3402415) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3402505..3403440) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" /label="yxxF CDS" gene complement(3402505..3403440) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /label="yxxF gene" downshifts complement(3402726) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(3403441..3403561) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3403592..3404038) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" /label="yxiE CDS" gene complement(3403592..3404038) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /label="yxiE gene" downshifts complement(3403606) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3404075..3404094) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3404082) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3404108..3404115) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3404141..3405550) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" /label="bglH CDS" gene complement(3404141..3405550) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /label="bglH gene" CDS complement(3405573..3407402) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" /label="bglP CDS" gene complement(3405573..3407402) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /label="bglP gene" promotor_no_box complement(3407394..3407494) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3407434) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="upshifts" S_feature complement(3407436..3407628) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3407609..3407628) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3407628) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3407630..3407763) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3407641..3407648) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3407785..3408093) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" /label="yxxE CDS" gene complement(3407785..3408093) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /label="yxxE gene" downshifts complement(3407808) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" /label="downshifts" CDS complement(3408139..3408582) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" /label="rtbE CDS" gene complement(3408139..3408582) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /label="rtbE gene" CDS complement(3408579..3410288) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" /label="rtbD CDS" gene complement(3408579..3410288) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /label="rtbD gene" misc_feature complement(3409450..3409469) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3409458) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="upshifts" CDS complement(3410308..3410577) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" /label="yxiC CDS" gene complement(3410308..3410577) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /label="yxiC gene" CDS complement(3410589..3410954) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" /label="yxiB CDS" gene complement(3410589..3410954) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /label="yxiB gene" S_feature complement(3410955..3411020) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3411007..3411026) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3411020) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3411041..3411044) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3411261..3412670) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" /label="abnB CDS" gene complement(3411261..3412670) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /label="abnB gene" downshifts complement(3411284) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" /label="downshifts" S_feature complement(3412671..3412780) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3412804..3412968) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" /label="yxzL CDS" gene complement(3412804..3412968) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /label="yxzL gene" promotor_-10 complement(3412853..3412871) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3412868) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3412882..3412890) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3413160..3413179) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3413176) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3413192..3413199) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3413208..3413215 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3413230..3413249 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3413233 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="upshifts" CDS 3413287..3413733 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" /label="hutP CDS" gene 3413287..3413733 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /label="hutP gene" downshifts 3413738 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" /label="downshifts" CDS 3413846..3415372 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" /label="hutH CDS" gene 3413846..3415372 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /label="hutH gene" CDS 3415369..3417027 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" /label="hutU CDS" gene 3415369..3417027 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /label="hutU gene" CDS 3417040..3418305 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" /label="hutI CDS" gene 3417040..3418305 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /label="hutI gene" CDS 3418298..3419257 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" /label="hutG CDS" gene 3418298..3419257 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /label="hutG gene" S_feature 3419258..3419332 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3419333..3420760 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" /label="hutM CDS" gene 3419333..3420760 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /label="hutM gene" downshifts 3420756 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3420804..3422105) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" /label="pdp CDS" gene complement(3420804..3422105) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /label="pdp gene" downshifts complement(3420821) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3422135..3423316) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" /label="nupC CDS" gene complement(3422135..3423316) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /label="nupC gene" S_feature complement(3423317..3423396) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3423397..3424068) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" /label="deoC CDS" gene complement(3423397..3424068) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /label="deoC gene" promotor_-35 3424017..3424020 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3424035 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3424036..3424055 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3424096..3424115) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3424111) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3424129..3424136) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3424174..3425115) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" /label="deoR CDS" gene complement(3424174..3425115) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /label="deoR gene" promotor_-10 complement(3425160..3425179) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3425166) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3425168..3425248) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3425195..3425198) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" SCAR 3425264..3425265 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_018" promotor_-35 3425361..3425367 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3425383..3425401 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3425393 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="upshifts" CDS 3425455..3426840 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" /label="csbC CDS" gene 3425455..3426840 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /label="csbC gene" downshifts 3426826 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 3426871..3427421 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3426882..3428762) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" /label="htpG CDS" gene complement(3426882..3428762) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /label="htpG gene" downshifts complement(3426888) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" S_feature complement(3428763..3428860) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3428851..3428870) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3428860) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3428885..3428892) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3428930..3429181) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" /label="yxcA CDS" gene complement(3428930..3429181) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /label="yxcA gene" downshifts complement(3428948) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" misc_feature complement(3429203..3429222) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3429212) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="upshifts" promotor_-35 3429245..3429251 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3429265..3429283 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3429266 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="upshifts" CDS 3429298..3430119 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" /label="yxbG CDS" gene 3429298..3430119 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /label="yxbG gene" downshifts 3430103 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" /label="downshifts" CDS complement(3430148..3431290) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" /label="yxbF CDS" gene complement(3430148..3431290) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /label="yxbF gene" downshifts complement(3430158) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3431291..3431390) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3431378..3431397) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3431389) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3431411..3431418) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3431433..3432770 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" /label="aldX CDS" gene 3431433..3432770 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /label="aldX gene" S_feature complement(3432175..3432775) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3432809..3433288) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " /label="yxbD CDS" gene complement(3432809..3433288) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /label="yxbD gene" downshifts complement(3432820) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3433368..3434360) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" /label="yxbC CDS" gene complement(3433368..3434360) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /label="yxbC gene" downshifts complement(3433392) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" /label="downshifts" downshifts 3434350 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3434383..3434402) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3434401) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3434417..3434424) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3434423..3434430 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3434444..3434868 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3434444 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3434445..3434464 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3434450..3434862 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="srlX RNA" gene 3434450..3434862 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /label="srlX gene" upshifts complement(3434470) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3434480..3434494) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3434502..3434506) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3434834 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" /label="downshifts" CDS 3434869..3435603 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" /label="yxbB CDS" gene 3434869..3435603 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /label="yxbB gene" CDS 3435603..3435872 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" /label="yxbA CDS" gene 3435603..3435872 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /label="yxbA gene" CDS 3435876..3436358 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" /label="yxnB CDS" gene 3435876..3436358 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /label="yxnB gene" CDS 3436379..3438622 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" /label="asnH CDS" gene 3436379..3438622 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /label="asnH gene" CDS 3438619..3439818 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" /label="yxaM CDS" gene 3438619..3439818 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /label="yxaM gene" promotor_-10 complement(3439574..3439592) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3439596) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3439607..3439613) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3439809 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts complement(3439882) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3439882..3441114) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" /label="yxaL CDS" gene complement(3439882..3441114) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /label="yxaL gene" promotor_-10 complement(3441146..3441165) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3441158) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3441179..3441184) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3441215..3441640) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" /label="yxaJ CDS" gene complement(3441215..3441640) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /label="yxaJ gene" promotor_-10 complement(3441668..3441687) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3441682) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3441700..3441706) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3441832..3441839 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3441849 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3441854..3441873 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3441897..3442352 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" /label="yxaI CDS" gene 3441897..3442352 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /label="yxaI gene" downshifts 3442290 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" S_feature 3442353..3442966 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3442382..3443590) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" /label="yxaH CDS" gene complement(3442382..3443590) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /label="yxaH gene" downshifts complement(3442409) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" /label="downshifts" S_feature complement(3443591..3443697) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3443698..3444711) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" /label="qdoI CDS" gene complement(3443698..3444711) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /label="qdoI gene" S_feature complement(3444712..3444785) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3444770..3444789) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3444785) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3444802..3444809) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3444805..3445380) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" /label="qdoR CDS" gene complement(3444805..3445380) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /label="qdoR gene" downshifts complement(3444829) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3445409..3445428) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3445423) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3445443..3445450) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3445451..3445457 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3445472..3445490 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3445479 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="upshifts" CDS 3445511..3446581 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" /label="yxnA CDS" gene 3445511..3446581 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /label="yxnA gene" downshifts 3446579 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3446638..3447069) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" /label="yxaD CDS" gene complement(3446638..3447069) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /label="yxaD gene" promotor_-35 3447099..3447106 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3447120..3447139 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3447129..3447295 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3447129 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3447181..3447200) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3447201) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3447215..3447222) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3447296..3447700 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" /label="yxzK CDS" gene 3447296..3447700 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /label="yxzK gene" S_feature complement(3447317..3448369) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3447670..3448362 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" /label="yxaC CDS" gene 3447670..3448362 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /label="yxaC gene" CDS complement(3448402..3449433) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" /label="yxaB CDS" gene complement(3448402..3449433) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /label="yxaB gene" downshifts complement(3448414) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-35 3449400..3449403 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3449416 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3449420..3449439 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3449470..3449488) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3449488) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3449503..3449509) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3449526..3450674) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" /label="glxK CDS" gene complement(3449526..3450674) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /label="glxK gene" promotor_-10 complement(3450713..3450732) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3450724) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3450743..3450750) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3450796..3450803 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3450817..3450836 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3450824 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3450870..3451601 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" /label="gntR CDS" gene 3450870..3451601 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /label="gntR gene" CDS 3451594..3453135 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" /label="gntK CDS" gene 3451594..3453135 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /label="gntK gene" CDS 3453164..3454510 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" /label="gntP CDS" gene 3453164..3454510 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /label="gntP gene" promotor_-35 3453963..3453967 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3453983..3454002 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3453992 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3454533..3455939 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" /label="gntZ CDS" gene 3454533..3455939 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /label="gntZ gene" downshifts 3455928 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3456036..3456055 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3456038..3456329 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3456038 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="upshifts" promotor_-35 3456302..3456309 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3456324..3456343 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3456331 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3456353..3456360 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3456375..3456394 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3456378) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3456381..3456395) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3456390 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3456403..3456407) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3456403..3456966 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" /label="ahpC CDS" gene 3456403..3456966 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /label="ahpC gene" CDS 3456980..3458509 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" /label="ahpF CDS" gene 3456980..3458509 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /label="ahpF gene" downshifts complement(3458336) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" /label="downshifts" downshifts 3458502 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3458535..3458618) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3458578) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3458619..3460058) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" /label="bglA CDS" gene complement(3458619..3460058) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /label="bglA gene" CDS complement(3460072..3460302) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" /label="ptsJ CDS" gene complement(3460072..3460302) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /label="ptsJ gene" S_feature complement(3460303..3460514) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3460511..3460530) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3460516) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3460545..3460552) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3460578..3460585 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3460596..3460615 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3460611 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="upshifts" CDS 3460646..3461356 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" /label="yydK CDS" gene 3460646..3461356 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /label="yydK gene" CDS 3461384..3461542 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" /label="yyzN CDS" gene 3461384..3461542 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /label="yyzN gene" downshifts 3461619 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3461673..3462395) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" /label="liaM CDS" gene complement(3461673..3462395) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /label="liaM gene" downshifts complement(3461685) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-35 3462296..3462299 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3462315..3462319 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3462330 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3462416..3463045) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" /label="liaL CDS" gene complement(3462416..3463045) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /label="liaL gene" S_feature complement(3463046..3463194) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3463195..3463953) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" /label="liaK CDS" gene complement(3463195..3463953) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /label="liaK gene" promotor_-10 complement(3463643..3463662) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3463659) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3463675..3463682) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3463934..3464893) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" /label="liaE CDS" gene complement(3463934..3464893) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /label="liaE gene" downshifts 3464882 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3464929..3464932 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3464937 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3464951..3465100) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" /label="liaD CDS" gene complement(3464951..3465100) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /label="liaD gene" downshifts complement(3464958) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" /label="downshifts" misc_feature 3465009..3465026 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3465014 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3465095 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3465121..3465140) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3465142) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3465155..3465162) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3465435..3465442 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3465457..3465476 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3465461 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="upshifts" CDS 3465572..3467497 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" /label="fbp CDS" gene 3465572..3467497 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /label="fbp gene" S_feature 3467498..3468862 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" S_feature complement(3467710..3468030) /Source="Nicolas_S_feature" /locus_tag="new_4130257_4130577_c" /HighExp="Cold, C30, M/G, S8, Fru, nit, Glu, BMM, Heat, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1545" CDS complement(3468031..3469791) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative DNA wielding protein" /protein_id="NP_391900.1" /db_xref="EnsemblGenomes-Gn:BSU40200" /db_xref="EnsemblGenomes-Tr:CAB16057" /db_xref="InterPro:IPR018760" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11477" /db_xref="UniProtKB/Swiss-Prot:Q45598" /translation="MIVMIIKNLFVCNSQEILKEYKFNAVGVNIILGEKREDHEETNG VGKSTMIECISFLLGKTISNFYTTNEILLNKNVFIVLNVEIDGNQVFLARSFNSPKHG YTLHDTSLTFNLEEWKKVSISVYKKFIEKEILKGEKEDITFAALREYIIRDEKTGFND IVLPNRGGLKQYKLLNYLFTLPTHTEKNIKVFRDKIEKLNSEIKLIESMNINIGDLKV KEDELINEIEDYNRVIYQTKTANKYNNDTNRYSEIKSELNKIQNEIFENEHICKQYQR NIDDLNKKVTKIKELENIEKFYEDIVGFFPEEVKQNYNKVQEFYNFMVESRGSYFKDK IVKIQADLKKLNIKKQGLTEQLESSARILKSNNFIEDISIVMEEQRRKEIELAEVRLR ISDYDKKNHIFDKINELQHEILRVNSMYYDEFQSYSAIVSELKKLFNNLMDVTYNQHG FLDFEYDNRISNAKQSTTGRIKISCSIPDERSHGRLHMKINIFDLTWFLYRCINKCSL NILIHDGSYSNPDPHVKGTLLKHINSSLLENRIGQYFVTINKNELLLDDLQELESKGM IVAKLDRNNEDKNRFFGFRF*" /label="yydD CDS" gene complement(3468031..3469791) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /label="yydD gene" downshifts complement(3468074) /Source="Nicolas_upshifts" /id="D2081" /incds=0 /nref=11 /ntot=199 /MaxReadThrough="4.99391" /MaxDrop="4.47843" /score="7.49162587" /energy="-10.5" /TU="U3167" /idTUdmin="U3167" /TUdmin="-322" /isTUend="FALSE" /label="downshifts" misc_feature 3468859..3468860 /Source="Nicolas_upshift_promotors" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3468864 /Source="Nicolas_upshifts" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3469791..3470189) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391901.1" /db_xref="EnsemblGenomes-Gn:BSU40210" /db_xref="EnsemblGenomes-Tr:CAB16058" /db_xref="SubtiList:BG11476" /db_xref="UniProtKB/Swiss-Prot:Q45599" /translation="MIDLKIETAENILKYSYVLLENEFKNIQIGNDLIPLVNNSPLKK EKAERPEMNHFLLTKYNAVEENILYSSKILYELLEKEKHIDQLFLDYAKSQGIIINLN IERILYLSLTFLYSLGKVSFNQNMISRTES*" /label="yydC CDS" gene complement(3469791..3470189) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /label="yydC gene" CDS complement(3470182..3471627) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphohydrolase" /protein_id="NP_391902.1" /db_xref="EnsemblGenomes-Gn:BSU40220" /db_xref="EnsemblGenomes-Tr:CAB16059" /db_xref="GOA:Q45600" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11475" /db_xref="UniProtKB/Swiss-Prot:Q45600" /translation="MKVRFLQISDLHFQFQNYDTIVMRDKLLDFIEVLRRESDFDFLL LTGDIAHKGDVYNEDVKEYLNGIIKSMGLSKNNVHLVPGNHDISRDMTRTLLIDSIMK SPNPSEMLDKLDQKATNILVEGQRKFFDFYEDFMGVKYPEEDLHFLYQSEKYNVLSIN TCLLSDKKGEEGTLLTAQMKLYKAIRKMNKEKNKGKVLNIAIGHHTLGCIESSERESI KAHFDDYFIDLYLAGHVHDSSFNITANTNENPFLELVSGAIIKDEYATPEFISVDVNL DNGETEVTYYIWNTEYKYWSKNNQGGRRLQEGKLNYKINRLESLIEKEIEDNDDKIDE DEFKSFIIDFHEYRESYKTFTSNFDNQIGLDKKFYDMKSGETFKRKFDSYSEYFGVIN HIMDSTSYVSADKKELIAETIVDKYLEFHNQYNNGDEIFVKIVNEIYLECHSVLPYSK ALTKKYIKILTCWCIYECEIFNDNKRSVKND*" /label="yydB CDS" gene complement(3470182..3471627) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /label="yydB gene" promotor_-35 3470877..3470884 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3470896..3470915 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3470906..3471955 /Source="Nicolas_S_feature" /locus_tag="new_4133453_4134502" /HighExp="C30, Salt, Gly, S8, Etha, LPhT, T0.30H, Heat, C90, M9-stat" /AntisenseName="yydB" /AntisenseCor="0.36202116146901597" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.431" /TUlongSig="NA" /TUlongPSig="NA" /label="S1546" upshifts 3470906 /Source="Nicolas_upshifts" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3471628..3471888) /Source="Nicolas_S_feature" /locus_tag="new_4134175_4134435_c" /HighExp="Cold, M0t90, Lbtran, M40t90, Lbstat, T0.30H, MG 150, M40t45, Gly, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1547" CDS complement(3471889..3472368) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /EC_number="2.1.1.177" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18755835, 20817755, 22411911, 22720735, 28428565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (pseudouridine1915-N3)-methyltransferase" /protein_id="NP_391903.1" /db_xref="EnsemblGenomes-Gn:BSU40230" /db_xref="EnsemblGenomes-Tr:CAB16060" /db_xref="GOA:Q45601" /db_xref="InterPro:IPR003742" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1TO0" /db_xref="SubtiList:BG11474" /db_xref="UniProtKB/Swiss-Prot:Q45601" /translation="MNINIVTIGKLKEKYLKQGIEEYTKRLSAYAKIDIIELPDEKAP ENLSDQDMKIIKDKEGDRILSKISPDAHVIALAIEGKMKTSEELADTIDKLATYGKSK VTFVIGGSLGLSDTVMKRADEKLSFSKMTFPHQLMRLILVEQIYRAFRINRGEPYHK* " /label="rlmH CDS" gene complement(3471889..3472368) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /label="rlmH gene" S_feature complement(3472369..3472448) /Source="Nicolas_S_feature" /locus_tag="new_4134916_4134995_c" /HighExp="dia5, LBGtran, T0.30H, Diami, Cold, M0t90, dia0, M0t45, M40t45, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1548" CDS complement(3472449..3472619) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097800.1" /db_xref="EnsemblGenomes-Gn:BSU40239" /db_xref="EnsemblGenomes-Tr:CAX52715" /db_xref="InterPro:IPR025626" /db_xref="UniProtKB/Swiss-Prot:C0H3T9" /translation="MKQAYYSCEEHIETVLDMYIDDHELPPEIRKIEHTNSLSTACEL CGDPAVYIVGNE*" /label="yyzF CDS" gene complement(3472449..3472619) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /label="yyzF gene" promotor_-10 complement(3472660..3472679) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3472676) /Source="Nicolas_upshifts" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3472693..3472698) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3472742..3472749 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3472762..3472781 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3472779 /Source="Nicolas_upshifts" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="upshifts" CDS 3472804..3473217 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21911367; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391904.1" /db_xref="EnsemblGenomes-Gn:BSU40240" /db_xref="EnsemblGenomes-Tr:CAB16061" /db_xref="SubtiList:BG11472" /db_xref="UniProtKB/Swiss-Prot:Q45603" /translation="MRFRWVWLFVIMLLLAECQPSYWVLEKDRIGEGSPDLEIYANYL QMHDDVKGYQVFTISEGKKMVVVSLGSSEKDKKLEVSDVKFSSKETIVTVERKPAPTA NEKNPFILIGLDKIEGDLIVQDETGDRFEETDYQQ*" /label="yycS CDS" gene 3472804..3473217 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /label="yycS gene" downshifts 3473197 /Source="Nicolas_upshifts" /id="D2082" /incds=0 /nref=17 /ntot=131 /MaxReadThrough="1.50241" /MaxDrop="5.73792" /score="16.0382598" /energy="-10.8" /TU="NA" /idTUdmin="U3168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3473251..3474477) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18820069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_391905.1" /db_xref="EnsemblGenomes-Gn:BSU40250" /db_xref="EnsemblGenomes-Tr:CAB16062" /db_xref="GOA:Q45604" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014184" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11471" /db_xref="UniProtKB/Swiss-Prot:Q45604" /translation="MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVN RKCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGD IVSVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYAD FQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAH SAQLLGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDC VGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIR FGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFD KGAAKKFVIDPHGTLK*" /label="yycR CDS" gene complement(3473251..3474477) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /label="yycR gene" downshifts complement(3473266) /Source="Nicolas_upshifts" /id="D2083" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="0.14321" /MaxDrop="4.77892" /score="8.82768619" /energy="-6.2" /TU="NA" /idTUdmin="U3169" /TUdmin=7 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3474500..3474518) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3474505) /Source="Nicolas_upshifts" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3474530..3474538) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3474540..3474710) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097801.1" /db_xref="EnsemblGenomes-Gn:BSU40259" /db_xref="EnsemblGenomes-Tr:CAX52716" /db_xref="GOA:C0H3U0" /db_xref="UniProtKB/Swiss-Prot:C0H3U0" /translation="MQTNRVILLAVMICLVSAITVFLLNGCKVDFLDIGGTIIGCFLG IFVVVRIQKKQS*" /label="yyzG CDS" gene complement(3474540..3474710) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /label="yyzG gene" promotor_-10 complement(3474729..3474747) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3474747) /Source="Nicolas_upshifts" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3474761..3474767) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3474815..3475063) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391906.1" /db_xref="EnsemblGenomes-Gn:BSU40260" /db_xref="EnsemblGenomes-Tr:CAB16063" /db_xref="GOA:Q45605" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG11470" /db_xref="UniProtKB/Swiss-Prot:Q45605" /translation="MGAIAVLFIVFGFPIVAGVFGIAGHFLFKRFWVAPLIVLITSLI LLVTLASGNSSFIFWVVMYTAIALVTSVATLFLRKFFE*" /label="yycQ CDS" gene complement(3474815..3475063) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /label="yycQ gene" CDS complement(3475079..3476242) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812, 16291680" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391907.2" /db_xref="EnsemblGenomes-Gn:BSU40270" /db_xref="EnsemblGenomes-Tr:CAB16064" /db_xref="InterPro:IPR011047" /db_xref="SubtiList:BG11469" /db_xref="UniProtKB/Swiss-Prot:Q45606" /translation="MKKWMITIAMLILAGIALFVFISPLKSHKTVSQQDLRNPDFLDD KEVLLYFSSSADQDAFGGGKSYALFISHDGTLSSFQMKGLELGSAKVHGDSVMLEDKN TIYTIKNGLRSHKRTYQHTGDSAGFLQNTDGFYTLYNSGYDKKGDGYRSELYRQMDGE WKKDVIPYYIRASGFHDGAIYALVPTDDGKGYQLLQIQADQKKLTYLSITEWQYREGA SVESQLAVDDQAVYVMVRGQKAHDLYQMVKINKKSGEVELHDIAEYKNDEQTIYSSMP FSFKNSFFPYDGNLYFIDGFGKVHKIDAKTGKTSIVFTLSPDKMKAEFKEITQKGSSL YFFTYTYHKPAYIEQYSLKTGKKMKEKEIGKVKDVVTPKSHLKLYDVEVMKRF*" /label="yycP CDS" gene complement(3475079..3476242) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /label="yycP gene" promotor_-10 complement(3475113..3475131) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3475121) /Source="Nicolas_upshifts" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3475143..3475151) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3476253..3476990) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_391908.1" /db_xref="EnsemblGenomes-Gn:BSU40280" /db_xref="EnsemblGenomes-Tr:CAB16065" /db_xref="SubtiList:BG11468" /db_xref="UniProtKB/Swiss-Prot:Q45607" /translation="MKLKKRVSMFLVALTMCGGLFVTPAKAVKTTNYAEEIAALQPGT TPEEIMKSASQIAKQQHVKQDVILKQFYKEITADKAEGDRLAKESGMSIMGGSSGTKK LPTSAKGNIYYTNSYTAYYNHGHVGMYSAADKIVESVPSDGVRQIAYNARDVEDNSIV QTVSVSSSQKTAAADWAVSKVGDPYSFNFVNNRNTGHDGAKNCSKLLWSAFLLKAGID IDSNGGLGVYPRDITSSSYTTTIMTIY*" /label="yycO CDS" gene complement(3476253..3476990) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /label="yycO gene" promotor_-10 complement(3477032..3477050) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3477038) /Source="Nicolas_upshifts" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3477064..3477072) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3477132..3477602) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14635137, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391909.1" /db_xref="EnsemblGenomes-Gn:BSU40290" /db_xref="EnsemblGenomes-Tr:CAB16066" /db_xref="GOA:O32293" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1ON0" /db_xref="PDB:1UFH" /db_xref="SubtiList:BG11467" /db_xref="UniProtKB/Swiss-Prot:O32293" /translation="MTIMLTPMQTEEFRSYLTYTTKHYAEEKVKAGTWLPEDAQLLSK QVFTDLLPRGLETPHHHLWSLKLNEKDIVGWLWIHAEPEHPQQEAFIYDFGLYEPYRG KGYAKQALAALDQAARSMGIRKLSLHVFAHNQTARKLYEQTGFQETDVVMSKKL*" /label="yycN CDS" gene complement(3477132..3477602) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /label="yycN gene" downshifts complement(3477145) /Source="Nicolas_upshifts" /id="D2084" /incds=0 /nref=1 /ntot=78 /MaxReadThrough="3.78599" /MaxDrop="2.94893" /score="8.04802973" /energy="-7.6" /TU="U3175" /idTUdmin="U3174" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3477603..3477673) /Source="Nicolas_S_feature" /locus_tag="new_4140150_4140220_c" /HighExp="S4, S5, S6, LoTm, S3, S7, S8, B36, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1549" promotor_-35 3477634..3477640 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3477654..3477673 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3477655..3477674) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3477655 /Source="Nicolas_upshifts" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3477673) /Source="Nicolas_upshifts" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3477675..3477950) /Source="Nicolas_S_feature" /locus_tag="new_4140222_4140497_c" /HighExp="S4, S5, S6, S7, S8, S3, B36, BT, LoTm, T5.0H" /AntisenseName="rapG" /AntisenseCor="-0.20647217228472101" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1550" promotor_-35 complement(3477689..3477696) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3477713..3478810 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391910.1" /db_xref="EnsemblGenomes-Gn:BSU40300" /db_xref="EnsemblGenomes-Tr:CAB16067" /db_xref="GOA:O32294" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11466" /db_xref="UniProtKB/Swiss-Prot:O32294" /translation="MNKIAPAEIASMLNDWYLAIKKHEVEESSRLFEEVKPLLDDMEE DQEVLAYFSLLELRHKVLLHEARGQGFQHEEPSHMNATSDMLKYYFFLFEGMYEAYKN NYDIAIGLYKDAEQYLDNIPDPIEKAEFHLKVGKLYYKLGQNIVSLNHTRQAVKTFRE ETDYKKKLASALITMSGNFTEMSQFEEAEAYLDEAIRITSELEDHFFEAQLLHNFGLL HAQSGKSEEAVSKLEEALQNDEYARSAYYYHSAYLLIRELFKIKKKEQALSYYQDVKE KLTAEPNRICEAKIDILYAIYAEGGHAETFHLCKQHMDDLLSEKEYDSVRELSILAGE RYRELELYKEAAHFFYEALQIEELIKRTEVI*" /label="rapG CDS" gene 3477713..3478810 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /label="rapG gene" promotor_-10 complement(3477941..3477959) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-10" upshifts complement(3477950) /Source="Nicolas_upshifts" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="upshifts" promotor_-35 complement(3477974..3477979) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-35" promotor_-35 3478534..3478542 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3478554..3478572 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3478567 /Source="Nicolas_upshifts" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="upshifts" CDS 3478811..3478927 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapG" /protein_id="NP_391911.1" /db_xref="EnsemblGenomes-Gn:BSU40310" /db_xref="EnsemblGenomes-Tr:CAB16068" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG11465" /db_xref="UniProtKB/Swiss-Prot:O32295" /translation="MKRFLIGAGVAAVILSGWFIADHQTHSQEMKVAEKMIG*" /label="phrG CDS" gene 3478811..3478927 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /label="phrG gene" downshifts 3478916 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3479164..3480054) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" /label="argI CDS" gene complement(3479164..3480054) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /label="argI gene" downshifts complement(3479170) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" downshifts complement(3479232) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" /label="downshifts" CDS complement(3480128..3481531) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" /label="rocE CDS" gene complement(3480128..3481531) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /label="rocE gene" S_feature complement(3481532..3481753) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3481754..3482959) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" /label="rocD CDS" gene complement(3481754..3482959) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /label="rocD gene" misc_feature complement(3483016..3483034) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3483019) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3483129..3483134 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3483149..3483168 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3483164 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="upshifts" CDS 3483200..3484585 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" /label="rocR CDS" gene 3483200..3484585 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /label="rocR gene" CDS complement(3484567..3484755) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" /label="yyzO CDS" gene complement(3484567..3484755) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo /label="yyzO gene" CDS complement(3484872..3485000) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" /label="hypothetical protein CDS" gene complement(3484872..3485000) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /label="gene" downshifts 3484924 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS complement(3485020..3486222) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" /label="htrC CDS" gene complement(3485020..3486222) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /label="htrC gene" downshifts complement(3485044) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3486254..3486265) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3486254) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3486280..3486286) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3486304..3487098) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" /label="walJ CDS" gene complement(3486304..3487098) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /label="walJ gene" CDS complement(3487120..3487962) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" /label="walI CDS" gene complement(3487120..3487962) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /label="walI gene" CDS complement(3487949..3489316) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /modified_by="User" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYTNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" /label="Delta6_BSU_40390_SNPvariant" gene complement(3487949..3489316) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /modified_by="User" /label="Delta6_BSU_40390_SNPvariant" Polymorphism join(3488543,3488545) /Source="geneious" /ID="SNP_BsDelta6_4151091_4151091" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="N -> T" /CDS_Position=773 /Change="T -> G" /Codon_Change="AAC -> ACC" /Coverage=184 /locus_tag="BSU_40390" /Protein_Effect="Substitution" /Reference_Frequency="0.5%" /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="Delta6_BSU_40390_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(3489306..3491141) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" /label="walK CDS" gene complement(3489306..3491141) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /label="walK gene" CDS complement(3491149..3491856) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" /label="walR CDS" gene complement(3491149..3491856) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /label="walR gene" S_feature complement(3491857..3491953) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3491941..3491960) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3491953) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3491955..3492147) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3491976..3491979) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3492147) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="upshifts" misc_feature complement(3492157..3492176) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3492239) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" tRNA complement(3492240..3492312) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Phe tRNA" gene complement(3492240..3492312) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /label="trnY-Phe gene" tRNA complement(3492348..3492424) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Asp tRNA" gene complement(3492348..3492424) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /label="trnY-Asp gene" S_feature complement(3492425..3492505) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3492506..3492577) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Glu tRNA" gene complement(3492506..3492577) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /label="trnY-Glu gene" tRNA complement(3492587..3492662) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Lys tRNA" gene complement(3492587..3492662) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /label="trnY-Lys gene" misc_feature 3492634..3492650 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3492647 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3492663..3492759) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3492743..3492762) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3492759) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3492776..3492783) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3492793..3492894) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3492833) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3492887..3494179) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" /label="purA CDS" gene complement(3492887..3494179) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /label="purA gene" downshifts complement(3492898) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3494219..3494238) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3494239) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3494253..3494260) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3494385..3494804) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" /label="yycE CDS" gene complement(3494385..3494804) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /label="yycE gene" promotor_-10 complement(3494802..3494813) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3494813) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3494828..3494834) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3494925..3496289) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" /label="dnaC CDS" gene complement(3494925..3496289) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /label="dnaC gene" downshifts complement(3494945) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3494989) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3496320..3496339) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3496334) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3496354..3496356) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3496401..3496407 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3496422..3496440 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3496424 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="upshifts" CDS 3496459..3496659 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" /label="yycD CDS" gene 3496459..3496659 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /label="yycD gene" downshifts 3496629 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" /label="downshifts" S_feature 3496674..3496995 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3496707..3496910) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" /label="yyzB CDS" gene complement(3496707..3496910) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /label="yyzB gene" S_feature complement(3496911..3497211) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3496976..3496979 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3496994..3497013 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3496997 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="upshifts" CDS 3497031..3497171 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" /label="yycC CDS" gene 3497031..3497171 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /label="yycC gene" S_feature 3497172..3497243 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3497219) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3497222..3497236) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3497244..3497248) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3497244..3498452 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" /label="yycB CDS" gene 3497244..3498452 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /label="yycB gene" downshifts 3498433 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3498557..3500614 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" /label="yycA CDS" gene 3498557..3500614 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /label="yycA gene" downshifts 3500479 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(3500651..3501100) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" /label="rplI CDS" gene complement(3500651..3501100) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /label="rplI gene" downshifts complement(3500665) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3501097..3503076) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" /label="gdpP CDS" gene complement(3501097..3503076) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /label="gdpP gene" misc_feature complement(3501578..3501597) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3501581) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3501994..3502001 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3502015..3502033 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3502019..3502685 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3502019 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3503113..3504042) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" /label="yybS CDS" gene complement(3503113..3504042) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /label="yybS gene" S_feature complement(3504043..3504179) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3504161..3504180) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3504179) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3504195..3504200) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3504269..3504418) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" /label="yyzH CDS" gene complement(3504269..3504418) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /label="yyzH gene" downshifts complement(3504295) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3504457..3504476) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3504474) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="upshifts" promotor_-35 complement(3504490..3504496) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3504497..3504506 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3504519..3504538 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3504525 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3504537) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3504539..3505052) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3504541..3504555) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3504564..3504568) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3504564..3505046 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" /label="cotF CDS" gene 3504564..3505046 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /label="cotF gene" downshifts 3505033 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3505076..3505453) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" /label="hypR CDS" gene complement(3505076..3505453) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /label="hypR gene" S_feature 3505078..3505607 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3505097) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3505508..3505527) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3505520) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3505541..3505548) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3505589..3505593 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3505607..3505626 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3505609 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3505634..3505648) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3505637) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3505658..3506587 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" /label="ppaC CDS" gene 3505658..3506587 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /label="ppaC gene" downshifts 3506573 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" /label="downshifts" SCAR 3506589..3506590 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="IIG_Bs27_014" CDS complement(3506592..3507146) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" /label="maa CDS" gene complement(3506592..3507146) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /label="maa gene" CDS complement(3507164..3507544) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" /label="yyaH CDS" gene complement(3507164..3507544) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /label="yyaH gene" CDS complement(3507600..3508535) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" /label="ccpB CDS" gene complement(3507600..3508535) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /label="ccpB gene" promotor_-35 3508525..3508534 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3508548..3508567 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3508555 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3508579..3508598) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3508593) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3508594..3509352) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" /label="exoA CDS" gene complement(3508594..3509352) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /label="exoA gene" promotor_-35 complement(3508611..3508618) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3508885..3509388 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3509347 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS complement(3509417..3509656) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" /label="rpsR CDS" gene complement(3509417..3509656) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /label="rpsR gene" downshifts complement(3509423) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3509491) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" /label="downshifts" CDS complement(3509700..3510218) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" /label="ssbA CDS" gene complement(3509700..3510218) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /label="ssbA gene" CDS complement(3510259..3510546) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" /label="rpsF CDS" gene complement(3510259..3510546) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /label="rpsF gene" S_feature complement(3510547..3510613) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3510612..3510631) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3510613) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3510645..3510650) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3510657..3511757) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" /label="engD CDS" gene complement(3510657..3511757) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /label="engD gene" promotor_-10 complement(3511805..3511824) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3511820) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="upshifts" promotor_-35 complement(3511839..3511846) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3511884..3513887) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" /label="yyaE CDS" gene complement(3511884..3513887) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /label="yyaE gene" CDS complement(3513938..3514144) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" /label="yyzM CDS" gene complement(3513938..3514144) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /label="yyzM gene" promotor_-10 complement(3514106..3514125) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3514131) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3514140..3514146) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3514170..3514189) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3514181) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="upshifts" promotor_-35 complement(3514206..3514210) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3514238..3515254) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" /label="yyaD CDS" gene complement(3514238..3515254) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /label="yyaD gene" promotor_-10 complement(3515287..3515305) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3515299) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3515321..3515326) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3515430) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" /label="downshifts" promotor_-35 3515614..3515619 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3515632..3515713 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3515632 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3515635..3515653 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3515714..3516331 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" /label="sprC CDS" gene 3515714..3516331 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /label="sprC gene" promotor_-35 3516302..3516310 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3516321 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 3516324..3516342 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3516343 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3516370..3517218) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" /label="parB CDS" gene complement(3516370..3517218) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /label="parB gene" downshifts complement(3516390) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" /label="downshifts" CDS complement(3517211..3517972) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" /label="parA CDS" gene complement(3517211..3517972) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /label="parA gene" misc_feature complement(3518006..3518025) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3518024) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3518116) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="upshifts" promotor_-10 complement(3518119..3518127) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3518141..3518149) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3518153..3518161 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3518169 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3518173..3518191 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3518220..3518660 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" /label="yyaB CDS" gene 3518220..3518660 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /label="yyaB gene" downshifts 3518609 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3518711..3519562) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" /label="nocA CDS" gene complement(3518711..3519562) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /label="nocA gene" downshifts complement(3518730) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(3519563..3519683) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3519684..3520403) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" /label="rsmG CDS" gene complement(3519684..3520403) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /label="rsmG gene" CDS complement(3520417..3522303) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" /label="trmF CDS" gene complement(3520417..3522303) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /label="trmF gene" CDS complement(3522324..3523703) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" /label="mnmE CDS" gene complement(3522324..3523703) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /label="mnmE gene" S_feature complement(3523704..3523834) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3523826..3523845) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3523834) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3523861..3523865) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3523889..3523908) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3523899) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="upshifts" promotor_-35 complement(3523922..3523929) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3523989..3523995 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3524000..3526285 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3524000 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3524010..3524029 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3524014..3524640) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" /label="jag CDS" gene complement(3524014..3524640) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /label="jag gene" downshifts complement(3524031) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3524637..3525422) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" /label="oxaAA CDS" gene complement(3524637..3525422) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /label="oxaAA gene" promotor_-10 complement(3525467..3525486) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3525479) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3525481..3525566) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3525498..3525504) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3525567..3525917) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" /label="rnpA CDS" gene complement(3525567..3525917) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /label="rnpA gene" S_feature complement(3525918..3526068) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3526069..3526203) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" /label="rpmH CDS" gene complement(3526069..3526203) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /label="rpmH gene" promotor_no_box 3526227..3526327 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3526239..3526258) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3526249) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3526251..3526319) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3526274..3526281) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3526287..>3526420 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3526287 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3526305..3526324) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3526319) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3526340..3526344) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3526421..3526568 /locus_tag="new_1_148" /created_by="stephanmichalik" /label="S1" S_feature complement(3526444..3526717) /locus_tag="new_24_297_c" /created_by="stephanmichalik" /label="S2" S_feature 3526570..3526829 /locus_tag="new_150_409" /created_by="stephanmichalik" /label="S3" ORIGIN 1 atggaaaata tattagacct gtggaaccaa gcccttgctc aaatcgaaaa aaagttgagc 61 aaaccgagtt ttgagacttg gatgaagtca accaaagccc actcactgca aggcgataca 121 ttaacaatca cggctcccaa tgaatttgcc agagactggc tggagtccag atacttgcat 181 ctgattgcag atactatata tgaattaacc ggggaagaat tgagcattaa gtttgtcatt 241 cctcaaaatc aagatgttga ggactttatg ccgaaaccgc aagtcaaaaa agcggtcaaa 301 gaagatacat ctgattttcc tcaaaatatg ctcaatccaa aatatacttt tgatactttt 361 gtcatcggat ctggaaaccg atttgcacat gctgcttccc tcgcagtagc ggaagcgccc 421 gcgaaagctt acaacccttt atttatctat gggggcgtcg gcttagggaa aacacactta 481 atgcatgcga tcggccatta tgtaatagat cataatcctt ctgccaaagt ggtttatctg 541 tcttctgaga aatttacaaa cgaattcatc aactctatcc gagataataa agccgtcgac 601 ttccgcaatc gctatcgaaa tgttgatgtg cttttgatag atgatattca atttttagcg 661 gggaaagaac aaacccagga agaatttttc catacattta acacattaca cgaagaaagc 721 aaacaaatcg tcatttcaag tgaccggccg ccaaaggaaa ttccgacact tgaagacaga 781 ttgcgctcac gttttgaatg gggacttatt acagatatca caccgcctga tctagaaacg 841 agaattgcaa ttttaagaaa aaaggccaaa gcagagggcc tcgatattcc gaacgaggtt 901 atgctttaca tcgcgaatca aatcgacagc aatattcggg aactcgaagg agcattaatc 961 agagttgtcg cttattcatc tttaattaat aaagatatta atgctgatct ggccgctgag 1021 gcgttgaaag atattattcc ttcctcaaaa ccgaaagtca ttacgataaa agaaattcag 1081 agggtagtag gccagcaatt taatattaaa ctcgaggatt tcaaagcaaa aaaacggaca 1141 aagtcagtag cttttccgcg tcaaatcgcc atgtacttat caagggaaat gactgattcc 1201 tctcttccta aaatcggtga agagtttgga ggacgtgatc atacgaccgt tattcatgcg 1261 catgaaaaaa tttcaaaact gctggcagat gatgaacagc ttcagcagca tgtaaaagaa 1321 attaaagaac agcttaaata gcaggaccgg ggatcaatcg gggaaagtgt gaataacttt 1381 tcggaagtca tacacagtct gtccacatgt ggataggctg tgtttcctgt ctttttcaca 1441 acttatccac aaatccacag gccctactat tacttctact attttttata aatatatata 1501 ttaatacatt atccgttagg aggataaaaa tgaaattcac gattcaaaaa gatcgtcttg 1561 ttgaaagtgt ccaagatgta ttaaaagcag tttcatccag aaccacgatt cccattctga 1621 ctggtattaa aattgttgca tcagatgatg gagtatcctt tacagggagt gactcagata 1681 tttctattga atccttcatt ccaaaagaag aaggagataa agaaatcgtc actattgaac 1741 agcccggaag catcgtttta caggctcgct tttttagtga aattgtaaaa aaattgccga 1801 tggcaactgt agaaattgaa gtccaaaatc agtatttgac gattatccgt tctggtaaag 1861 ctgaatttaa tctaaacgga ctggatgctg atgaatatcc gcacttgccg cagattgaag 1921 agcatcatgc gattcagatc ccaactgatt tgttaaaaaa tctaatcaga caaacagtat 1981 ttgcagtgtc cacctcagaa acacgcccta tcttgacagg tgtaaactgg aaagtggagc 2041 aaagtgaatt attatgcact gcaacggata gccaccgtct tgcattaaga aaggcgaaac 2101 ttgatattcc agaagacaga tcttataacg tcgtgattcc gggaaaaagt ttaactgaac 2161 tcagcaagat tttagatgac aaccaggaac ttgtagatat cgtcatcaca gaaacccaag 2221 ttctgtttaa agcgaaaaac gtcttgttct tctcacggct tctggacggg aattatccag 2281 acacaaccag cctgattccg caagacagca aaacagaaat cattgtgaac acaaaagaat 2341 tccttcaggc cattgatcgt gcatctcttt tagctagaga gggacgcaac aacgttgtaa 2401 aactgtccgc aaaaccggct gaatccattg aaatttcttc caattcgcca gaaatcggta 2461 aagttgtgga agcaattgtt gcggatcaaa ttgaaggtga ggaattaaat atctctttta 2521 gtccaaaata tatgctggat gcactaaagg tgcttgaagg agcagaaata cgcgtaagct 2581 ttacaggcgc aatgagacct ttcttaattc gcacgccgaa tgatgaaacg attgtacagc 2641 ttatccttcc tgtcagaacc tattaatccg atacactgct gccgacccgt cggcagcttt 2701 tctattcggt atctgctccg acaagttttc cctttcccta attcgttttt ttttagtaca 2761 attagatatt agtgatattt gaaagaggtc gatataatgg caaatccgat ttcaattgat 2821 acagagatga ttacactcgg acaattctta aaattagccg atgtgattca gtctggcggt 2881 atggcgaagt ggtttttaag cgagcatgaa gtgcttgtga acgatgagcc ggacaaccgc 2941 cggggcagaa agctgtatgt tggagatgtg gtagagattg aaggatttgg ttcatttcaa 3001 gtcgtcaatt aaagcgggtg acactgattg tatatccaga acttagaact gacatcttac 3061 cgcaactacg accatgctga acttcaattt gaaaataaag taaatgtgat catcggagaa 3121 aacgcccagg ggaagacaaa cctcatggag gcgatctatg tcttgtccat ggcgaaatcg 3181 caccggacat caaatgacaa agaacttata cggtgggaca aagactatgc taaaatagag 3241 ggaagagtga tgaagcaaaa cggggcgatc ccgatgcagc tcgtcatctc caaaaagggt 3301 aaaaagggca aggtcaatca tattgaacag caaaagctca gccagtatgt cggggccctc 3361 aacaccatta tgttcgcgcc ggaagattta aatcttgtaa agggaagccc tcaagtgaga 3421 aggcggtttc ttgacatgga aatcggacag gtttctcccg tctaccttca tgatctttct 3481 ctttaccaga aaatcctttc ccagcggaat cattttttga aacagctgca aacaagaaaa 3541 caaactgacc ggacgatgct cgatgttctg accgatcagc ttgtagaagt tgcagcaaaa 3601 gtcgtcgtaa aacgcctgca gtttacagca cagctcgaga aatgggcgca gcccatccat 3661 gcaggcatct caagagggct tgaagaactg accctgaaat accatacagc tcttgatgta 3721 tcagatcccc tagatttgtc gaaaatagga gatagctatc aagaagcgtt ttctaaatta 3781 agagaaaaag aaattgagcg tggtgtgacg ctgtcagggc ctcatcgcga tgatgttctt 3841 ttctatgtga acggacgcga tgtgcagacg tatggttctc aaggacagca gcgaacgacg 3901 gcgttgtccc ttaagctggc ggagattgac ctgatccatg aagaaatcgg agaatatccc 3961 attttactat tggatgatgt actgagtgaa ctggatgatt atcgccagtc acacttgctt 4021 catacgatcc aaggccgtgt acaaacgttt gtcacaacga caagcgttga tggcattgat 4081 cacgaaacct tacgtcaagc aggaatgttc cgtgtgcaaa atggtgcgtt agtgaagtga 4141 agaaatgagg tgagcaattg tatattcatt taggtgatga ctttgtggtt tcaacacgag 4201 atattgtcgg catttttgac tttaaagcca acatgtcgcc tattgttgaa gaatttctga 4261 aaaaacagaa acacaaggtg gtgccttccg taaacggcac gcccaaatct atcgtagtca 4321 cggttcagaa tatatattac tctcccttat cttccagcac attaaaaaaa cgtgcgcaat 4381 ttatgtttga aatagattct tagaaatttt ttatcacgaa tatatcgttt agaaaagtgt 4441 aggtgaatga cgtggctatg gaacagcagc aaaacagtta tgatgaaaat cagatacagg 4501 tactagaagg attggaagct gttcgtaaaa gaccggggat gtatatcggt tcgacaaaca 4561 gcaaaggcct tcaccacttg gtatgggaaa ttgtcgacaa tagtattgac gaagccctcg 4621 ccggttattg tacggatatc aatatccaaa tcgaaaaaga caacagtatc acggttgtag 4681 ataatggccg cggtattcca gtcggtattc atgaaaaaat gggccgtcct gcggtagaag 4741 tcattatgac ggtgcttcat gccggaggaa aatttgacgg aagcggctat aaagtatccg 4801 gaggattaca cggtgtaggt gcgtcggtcg taaacgcact atcaacagag cttgatgtga 4861 cggttcaccg tgacggtaaa attcaccgcc aaacctataa acgcggagtt ccggttacag 4921 accttgaaat cattggcgaa acggatcata caggaacgac gacacatttt gtcccggacc 4981 ctgaaatttt ctcagaaaca accgagtatg attacgatct gcttgccaac cgcgtgcgtg 5041 aattagcctt tttaacaaag ggcgtaaaca tcacgattga agataaacgt gaaggacaag 5101 agcgcaaaaa tgaataccat tacgaaggcg gaattaaaag ttatgtagag tatttaaacc 5161 gctctaaaga ggttgtccat gaagagccga tttacattga aggcgaaaag gacggcatta 5221 cggttgaagt ggctttgcaa tacaatgaca gctacacaag caacatttac tcgtttacaa 5281 acaacattaa cacgtacgaa ggcggtaccc atgaagctgg cttcaaaacg ggcctgactc 5341 gtgttatcaa cgattacgcc agaaaaaaag ggcttattaa agaaaatgat ccaaacctaa 5401 gcggagatga cgtaagggaa gggctgacag cgattatttc aatcaaacac cctgatccgc 5461 agtttgaggg ccaaacaaaa acaaagctgg gcaactcaga agcacggacg atcaccgata 5521 cgttattttc tacggcgatg gaaacattta tgctggaaaa tccagatgca gccaaaaaaa 5581 ttgtcgataa aggtttaatg gcggcaagag caagaatggc tgcgaaaaaa gcgcgtgaac 5641 taacacgccg taagagtgct ttggaaattt caaacctgcc cggtaagtta gcggactgct 5701 cttcaaaaga tccgagcatc tccgagttat atatcgtaga gggtgactct gccggaggat 5761 ctgctaaaca aggacgcgac agacatttcc aagccatttt gccgcttaga ggtaaaatcc 5821 taaacgttga aaaggccaga ctggataaaa tcctttctaa caacgaagtt cgctctatga 5881 tcacagcgct cggcacaggt atcggagaag acttcaacct tgagaaagcc cgttaccaca 5941 aagttgtcat tatgacagat gccgatgttg acggcgcgca catcagaaca ctgctgttaa 6001 cgttctttta cagatatatg cgccaaatta tcgaaaatgg ctacgtgtac attgcgcagc 6061 cgccgctcta caaggttcaa caggggaaac gcgttgaata tgcatacaat gacaaggagc 6121 ttgaagagct gttaaaaact cttcctcaaa cgcctaagcc tggactgcag cgttacaaag 6181 gtcttggtga aatgaatgcc acccagctat gggagacaac catggatcct agctccagaa 6241 cacttcttca ggtaactctt gaagatgcaa tggatgcgga tgagactttt gaaatgctta 6301 tgggcgacaa ggtagaaccg cgccgaaact tcatagaagc gaatgcgaga tacgttaaaa 6361 atcttgacat ctaatcataa aaagccttat ttccaataag aaataaggct tttttctgaa 6421 caagatcaga tgcagcgatg cctgcaatac ctatatattc tagcaattta atgtgtataa 6481 tcataagttt attgatataa tggagaatag tgaaatcgta ttgaaggtca taatggacaa 6541 tctactccca catatttcat gtgatacttc agggaggttt tttaatgagt gaacaaaaca 6601 caccacaagt tcgtgaaata aatatcagtc aggaaatgcg tacgtccttc ttggattatg 6661 caatgagcgt tatcgtgtcc cgtgctcttc cggatgttcg tgacggttta aaaccggttc 6721 atagacggat tttgtatgca atgaatgatt taggcatgac aagtgacaag ccttataaaa 6781 aatccgcgcg tatcgttgga gaagttatcg ggaaatacca cccgcacggt gattcagcgg 6841 tatatgaatc catggtcaga atggctcagg atttcaacta ccgttatatg ctcgttgacg 6901 gtcacggaaa cttcggttct gttgacggag actcagcggc ggccatgcgt tatacagaag 6961 cacgaatgtc taaaatctca atggagattc ttcgcgacat cacaaaagac acaatcgatt 7021 accaggataa ctatgacggg tcagaaagag aacctgtcgt tatgccttca aggttcccga 7081 atctgctcgt gaacggtgct gccggcattg cggtaggtat ggcaacaaac attcctccgc 7141 accagctggg agaaatcatt gacggtgtac ttgctgttag tgagaatccg gacattacaa 7201 ttccagagct tatggaagtc attccagggc ctgatttccc gaccgcgggt caaatcttgg 7261 gacgcagcgg tatccggaaa gcatacgaat caggccgagg ctctatcacg atccgggcaa 7321 aagctgagat cgaacaaaca tcttcgggta aagaaagaat tatcgttaca gagttacctt 7381 accaagtaaa taaggcgaaa ttaattgaga aaattgctga tctcgtaagg gacaaaaaga 7441 tagagggtat cacagatctg cgtgatgagt cagatcgtac aggtatgaga attgtcattg 7501 aaatcagacg cgatgccaat gcgaatgtta tcttaaacaa tctgtacaaa caaactgctc 7561 tacaaacatc ttttggcatc aacctgcttg cgcttgttga tggccagccg aaagttttaa 7621 ctcttaagca atgcctggag cattaccttg accatcaaaa agttgtcatt agacgccgta 7681 ctgcttatga attgcgtaaa gcagaagcga gagctcatat cttggaagga ttgagagttg 7741 cactggatca tctcgatgca gttatctccc ttatccgtaa ttctcaaacg gctgaaattg 7801 cgagaacagg tttaattgaa caattctcac tgacagagaa gcaagcacaa gcgatccttg 7861 acatgaggct ccagcgttta acgggactgg aacgtgaaaa gatcgaagaa gaataccagt 7921 ctcttgttaa attaattgca gagctaaaag acatcttggc aaatgaatat aaagtgcttg 7981 agatcattcg tgaagaactc acggaaatca aagagcgttt taacgatgaa agacgtactg 8041 agatcgtcac ttctggactg gagacaattg aagatgaaga tctcatcgag agagaaaata 8101 tcgtagttac tctgacgcac aacggatacg tcaaacgtct tcctgcatca acttaccgca 8161 gtcaaaaacg gggcggaaaa ggtgtacaag gtatgggaac aaacgaagat gatttcgttg 8221 aacatttgat ctctacgtca actcatgaca cgattctctt cttctcgaac aaggggaaag 8281 tgtatcgtgc aaaagggtat gaaatccctg aatacggcag aacggcaaaa ggaatcccga 8341 ttattaacct gctggaggta gaaaagggtg agtggatcaa cgcgattatt ccagtcacgg 8401 aattcaatgc ggagctttac ctcttcttca ctacaaagca tggggtttca aaacgaacat 8461 cgctatctca attcgctaat atccgcaaca atggtctaat tgctctgagt cttcgtgaag 8521 atgatgaact gatgggtgta cgtctgactg acggcacaaa acaaatcatc attggaacga 8581 aaaacggttt actgattcgt ttccctgaaa cagatgtccg agagatggga agaactgcgg 8641 cgggcgtaaa aggcatcacc ctgacggatg acgacgttgt tgtcggcatg gagattttag 8701 aggaagaatc acacgtcctt atcgtaactg aaaaagggta cggaaaacga actcctgctg 8761 aagagtacag aacccaaagc cggggcggaa aaggactcaa aacagcgaaa atcaccgaga 8821 acaacggcca actagtagca gtgaaagcta ctaaaggtga agaggatcta atgattatta 8881 cagctagcgg cgtactcatc agaatggaca tcaatgatat ctccatcacc ggacgtgtca 8941 ctcaaggtgt gcgtctcatc agaatggcag aagaagagca tgttgctaca gtagctttag 9001 ttgagaaaaa cgaagaagat gagaatgaag aagaacaaga agaagtgtga aaaaaagcgc 9061 agctgaaata gctgcgcttt tttgtgtcat aaccctttac agtcataaaa attatggtat 9121 aatcatttct gttgtctttt taaagacaca agcatgacca ttatgactag taaaaacttt 9181 ttcaaaaaag tattgaccta gttaactaaa aatgttacta ttaagtagtc gctttgagag 9241 aagcacacaa agttctttga aaactaaaca agacaaaacg tacctgttaa ttcattttta 9301 taaatcgcac agcgatgtgc gtagtcagtc aaactagggc ctgcacgacg caggtcacac 9361 aggtgtcgcc gcaggatgcg gtgaacttaa cctgtgatcc atttatcgga gagtttgatc 9421 ctggctcagg acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg 9481 agcttgctcc ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa 9541 gactgggata actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt 9601 caaacataaa aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt 9661 tggtgaggta acggctcacc aaggcgacga tgcgtagccg acctgagagg gtgatcggcc 9721 acactgggac tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc 9781 aatggacgaa agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa 9841 gctctgttgt tagggaagaa caagtgccgt tcgaataggg cggtaccttg acggtaccta 9901 accagaaagc cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt 9961 tgtccggaat tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc 10021 ccccggctca accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag 10081 tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg 10141 cgactctctg gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag 10201 ataccctggt agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct 10261 tagtgctgca gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac 10321 tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac 10381 gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt 10441 cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt 10501 taagtcccgc aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta 10561 aggtgactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct 10621 tatgacctgg gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg 10681 ttaagccaat cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg 10741 aagctggaat cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt 10801 gtacacaccg cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt 10861 ttaggagcca gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc 10921 gtatcggaag gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc 10981 ttgggtctta taaacagaac gttccctgtc ttgtttagtt ttgaaggaac tttgttcctt 11041 gaataagtta agatgggcct gtagctcagc tggttagagc gcacgcctga taagcgtgag 11101 gtcggtggtt cgagtccact caggcccacc atcttatata acggggcctt agctcagctg 11161 ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg ctccaccaac 11221 gtgttctttg aaaactagat aacagtagac atcacattca attagtaaca caagatatca 11281 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 11341 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 11401 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 11461 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 11521 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga 11581 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg 11641 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 11701 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 11761 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 11821 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 11881 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatctc 11941 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 12001 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 12061 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 12121 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 12181 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 12241 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 12301 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 12361 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 12421 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 12481 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 12541 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 12601 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 12661 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 12721 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 12781 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 12841 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 12901 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 12961 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 13021 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 13081 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 13141 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 13201 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 13261 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 13321 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 13381 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 13441 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 13501 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 13561 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 13621 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 13681 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 13741 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 13801 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 13861 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 13921 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 13981 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 14041 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 14101 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 14161 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact 14221 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaac actctcaatt 14281 tgtttggtgg cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc 14341 tcttcagcgc cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa 14401 gcttaaaccc agctcaatga gctgggtttt ttgtttgtta aaaatgaaga agaaactgtg 14461 aagcgtattt agggaatttc ttttctgata ctaataaaaa ctgctgaatt aacacgtagt 14521 catcacttat atgctgtgtt aataactcat accaccattc tgtttcatac cttgcaatca 14581 tcccaacgtt gtacaaaatc aaataatgaa ttgtcatttc gggaagcctc agaaattgct 14641 ccctttgaga agggatataa tattggttct tttccatgtc aaacaataag ctggtcgatg 14701 tccatggctc cttgtcttgt ggtgaaattt cgaacagcag cccgtgttca tttttttttg 14761 taaaagacca ttgataatga tgggacatgt attcagcaaa ccttgaatca gacattttgt 14821 aattgattac tacttcctcc ggtacaaaaa tttcgttctt atccttctca acttttgtca 14881 taaatcgttc tttctgctga aagtagaaaa tatcgctaag ttctggaatg gccattaata 14941 attttttcat ggtataccgt tcatctacta tatccgattg tccgaataaa tgtttcataa 15001 aatgtacgca taggccattc cgttgtattt tcacttcatc gtcgctaaaa caataatttt 15061 gtttctttcg ttttcttgtt gttacgccat gtgccagtac tgatgtatgg cttggataat 15121 gaggatcacg tgtaattaag catgctttga taagctgtgc cattccataa aataaaagaa 15181 tcggtttgat ttctaaggga gaatatgcgg cttgtttata aaacgattcg gcatgcttta 15241 agaaataaat aaaccgttca ctgtttttaa aagagttttt tttcgcatcg ttaataccgt 15301 ttaagatata aaccttttct agaaatttct gggttgattc aacggagtaa aatagcgcta 15361 agtctttcca ctcatgatat gtcatgtata tttcttaatc ctttccgtta tctaaatatt 15421 tcaactcttt cccgcttcct tgacatgctc ttggctagtt gataatctac atataatatt 15481 ttgccgaaaa gagggggatt tactaatgtg ggaaagtaaa ttttcaaaag aaggcttaac 15541 gttcgacgat gtgctgcttg taccagcaaa gtctgaggta cttccgcgtg atgtggattt 15601 atctgtagaa cttacaaaaa cgttaaagct aaatattcct gtcatcagcg caggtatgga 15661 cactgtaaca gaatcagcaa tggcaattgc aatggcaaga cagggcggct tgggcatcat 15721 tcacaaaaat atgtccattg aacagcaggc tgaacaagtt gataaagtaa agcgttctga 15781 gcgcggcgtt atcacaaatc ccttcttttt aactcctgat caccaagtat ttgatgcgga 15841 gcatttgatg gggaaataca gaatttccgg tgttccgatt gtaaataacg aagaagacca 15901 gaagcttgtt ggaattatta caaaccgtga ccttcgtttt atttctgact actcaatgaa 15961 aatcagcgac gtcatgacga aagaagagct agttactgca tctgtaggaa ctactctgga 16021 tgaagctgaa aagattttgc agaaacataa aattgaaaag cttcctctcg tagatgacca 16081 gaataaatta aaaggtctta tcacaattaa agacattgaa aaagtcattg agttcccgaa 16141 ctcatctaaa gacattcacg gccgcctgat cgttggcgcg gcagttggtg taactggcga 16201 tacaatgact cgcgtcaaaa agcttgttga agccaatgtt gatgtgattg ttatcgatac 16261 agctcacgga cactctcaag gcgttttaaa cacagtcaca aaaatccgtg aaacgtatcc 16321 cgaattaaac attattgctg gaaacgtggc aacagctgaa gcgacaagag cgcttatcga 16381 agctggagca gacgttgtca aagttggaat agggcctggt tcaatttgta ctacacgtgt 16441 tgtagccggc gtgggtgttc cgcaaattac agcaatttat gattgtgcga ctgaagcaag 16501 aaaacacggc aaaacaatca tcgccgacgg tgggattaaa ttctctggcg atatcactaa 16561 agcattggca gccggcggac atgctgttat gctcggaagc ttgcttgcag gcacatcaga 16621 aagccctggt gaaactgaaa tctaccaagg cagaagattt aaggtatacc gcggcatggg 16681 atcagttgct gcaatggaaa aaggaagtaa agaccgttac ttccaagaag aaaacaaaaa 16741 atttgttcct gaaggaattg aaggacgcac accttacaaa gggccagttg aagaaaccgt 16801 ttatcagcta gtcggaggcc ttcgttctgg tatggggtat tgcgggtcca aagatctgcg 16861 tgcgctaaga gaagaagctc agttcattcg catgactggc gcaggacttc gcgaaagcca 16921 tccgcatgac gtacagatta caaaagaatc acctaactat acaatttcat aataaattgt 16981 tacaaattaa aaacatttga cagggtctct gactctgtct atttttttta tactgattat 17041 gataaaattt atactgttgt gcattgaaaa tgtccttaac ggcttaatta tagatgaaga 17101 aaatgaaata cggaggtcgt acgattgaac atcaagaaat gtaaacagct actgatgtca 17161 ttggttgtgt taactctagc tgtcacgtgt ctggctccaa tgtcaaaagc gaaagcagcc 17221 agcgatccaa ttgatatcaa tgcatctgct gctattatga tcgaagcttc ttcaggtaaa 17281 attctttaca gtaaaaatgc agataagaga ctgccaattg cgagtatgac aaaaatgatg 17341 acagagtatc tgttattgga agcaattgat caaggtaaag tgaaatggga ccaaacctat 17401 acgcctgatg actatgtgta tgaaatttcc caagataaca gcttatcaaa cgttcctctt 17461 cggaaagacg ggaaatacac agtaaaagaa ttatatcaag ctacagcaat ttattctgca 17521 aatgctgctg ctattgcgat tgcagaaatc gttgccggtt ctgaaactaa gtttgttgaa 17581 aaaatgaatg caaaagcaaa agaactaggc ttaacagatt acaaatttgt taacgcaaca 17641 ggtcttgaaa acaaagatct tcacgggcat cagcctgagg ggacaagcgt aaatgaagaa 17701 agtgaagttt ctgcaaagga tatggcggtt cttgcggatc acttgattac tgactaccct 17761 gagatactgg agacttccag tatcgccaaa acgaaattca gagaaggcac cgatgatgaa 17821 atggacatgc cgaactggaa ttttatgctg aaggggcttg tcagcgagta taaaaaagcg 17881 actgtagacg gactgaaaac aggttctact gactctgcgg gttcatgctt tacaggaaca 17941 gctgaacgca acggtatgcg tgtcatcact gttgttttaa acgcaaaggg caaccttcat 18001 acaggccgtt tcgatgaaac gaaaaaaatg tttgattatg ctttcgacaa tttctccatg 18061 aaagaaattt atgctgaagg cgatcaagta aaaggccata aaacaatttc agttgataag 18121 ggtaaagaga aagaagtagg cattgtgaca aacaaggcgt tctctcttcc tgtcaaaaat 18181 ggtgaagaaa agaattacaa agcgaaggtc acactgaata aagacaactt aactgctcct 18241 gtgaaaaaag gaaccaaggt tgggaagctg actgcggaat acacaggtga tgaaaaggat 18301 tacggattcc ttaacagcga tctggctggc gtagaccttg ttacaaaaga aaatgtagaa 18361 aaagcaaact ggtttgtttt gacaatgcgc agtatcggcg gattttttgc cggaatttgg 18421 ggaagcattg ttgatacggt aaccggctgg ttttaatcaa ttgaaagagc tctgatggat 18481 gttagggctc tttcgcgtaa tatactgaaa aaacccaatt tttaataaaa aatgattttc 18541 aaagcgctaa aaaccgaata aaatagtata tatgcatatg aattattgga tttctaggat 18601 acaataagga ttagaaatca tataactata ccttgattag ggggaccaag aaatggctca 18661 aacaggtact gaacgtgtaa aacgcggaat ggcagaaatg caaaaaggcg gcgtcatcat 18721 ggacgtcatc aatgcggaac aagcgaaaat cgctgaagaa gctggagctg tcgctgtaat 18781 ggcgctagaa cgtgtgccag cagatattcg cgcggctgga ggagttgccc gtatggctga 18841 ccctacaatc gtggaagaag taatgaatgc agtatctatc ccggtaatgg caaaagcgcg 18901 tatcggacat attgttgaag cgcgtgtgct tgaagctatg ggtgttgact atattgatga 18961 aagtgaagtt ctgacgccgg ctgacgaaga atttcattta aataaaaatg aatacacagt 19021 tccttttgtc tgtggctgcc gtgatcttgg tgaagcaaca cgccgtattg cggaaggtgc 19081 ttctatgctt cgcacaaaag gtgagcctgg aacaggtaat attgttgagg ctgttcgcca 19141 tatgcgtaaa gttaacgctc aagtgcgcaa agtagttgcg atgagtgagg atgagctaat 19201 gacagaagcg aaaaacctag gtgctcctta cgagcttctt cttcaaatta aaaaagacgg 19261 caagcttcct gtcgttaact ttgccgctgg cggcgtagca actccagctg atgctgctct 19321 catgatgcag cttggtgctg acggagtatt tgttggttct ggtattttta aatcagacaa 19381 ccctgctaaa tttgcgaaag caattgtgga agcaacaact cactttactg attacaaatt 19441 aatcgctgag ttgtcaaaag agcttggtac tgcaatgaaa gggattgaaa tctcaaactt 19501 acttccagaa cagcgtatgc aagaacgcgg ctggtaagaa cataggagcg ctgctgacat 19561 gttaacaata ggtgtactag gacttcaagg agcagttaga gagcacatcc atgcgattga 19621 agcatgcggc gcggctggtc ttgtcgtaaa acgtccggag cagctgaacg aagttgacgg 19681 gttgattttg ccgggcggtg agagcacgac gatgcgccgt ttgatcgata cgtatcaatt 19741 catggagccg cttcgtgaat tcgctgctca gggcaaaccg atgtttggaa catgtgccgg 19801 attaattata ttagcaaaag aaattgccgg ttcagataat cctcatttag gtcttctgaa 19861 tgtggttgta gaacgtaatt catttggccg gcaggttgac agctttgaag ctgatttaac 19921 aattaaaggc ttggacgagc cttttactgg ggtattcatc cgtgctccgc atattttaga 19981 agctggtgaa aatgttgaag ttctatcgga gcataatggt cgtattgtag ccgcgaaaca 20041 ggggcaattc cttggctgct cattccatcc ggagctgaca gaagatcacc gagtgacgca 20101 gctgtttgtt gaaatggttg aggaatataa gcaaaaggca cttgtataaa acagttgaaa 20161 gctgtggaaa cttatagtac attataagca caaataaaga tcgaaaagcg ttgataggaa 20221 ctagtaggga gcctctcttt ctaagagagc cgatggttgg tgcgaatcgg tgaaagatgc 20281 tgtctgaatc catccttgag cgaaatgctg aagcgagtag gcatttacgg gataaccgtt 20341 atgtttgaaa gtggaaaacg agtctttgat ttgttttcaa tcagggtggc aacgcgagag 20401 ctctcgtccc tttatgggga tgagggctct ttttattttc gataaatcaa taaaaaaagg 20461 agtgtttcgc atgcttgata cgaaaatgct gagagcaaat tttcaagaaa ttaaagcaaa 20521 gcttgtacac aaaggcgaag acttaactga ttttgataag tttgaggcgc tggatgatag 20581 acgaagagag cttatcggca aggttgaaga gttaaaagga aaacgaaatg aagtttctca 20641 gcaggttgct gtgctgaagc gtgagaaaaa agacgcggat cacattatta aagaaatgcg 20701 tgaagtcggc gaggaaatta aaaagctcga tgaagaatta cggacagtgg aagctgagct 20761 tgatacaatc ctgctctcaa tcccgaatat tccgcatgag tctgtacctg tcggtgaaac 20821 agaagacgac aacgtagaag tgcgtaaatg gggtgaaaag ccttcatttg cttatgagcc 20881 gaagccgcac tgggatattg cggatgagct gggtattctg gattttgaac gtgctgccaa 20941 agtaacagga agccgtttcg tgttctataa aggcttaggt gctcgtctgg agcgtgcgct 21001 ttataacttt atgcttgatc tgcatgtgga tgagtataac tacactgaag tgatcccgcc 21061 atatatggta aaccgcgcaa gcatgacggg aacggggcag cttcctaaat ttgaagagga 21121 tgcatttaaa atcagagaag aagattattt cttaattcca acggcggaag tgccgattac 21181 aaacatgcat cgcgatgaaa tcctttcagg tgacagcctg ccgatcaact atgcggcatt 21241 cagtgcttgc ttccgttctg aagctggttc agcaggacgt gacacacgcg gattaattcg 21301 tcagcaccaa tttaataaag ttgagcttgt aaagtttgtg aagcctgaag attcttatga 21361 agaattagag aaacttacaa accaagcaga acgggttctt cagctgcttg agcttccata 21421 ccgtgtcatg agcatgtgta cgggtgactt aggctttacg gctgcgaaaa aatacgatat 21481 cgaagtttgg attccaagcc aagacacata tcgagaaatc tcttcttgca gcaacttcga 21541 agcgttccag gcgagacgtg cgaatattcg tttcagacgt gaagcgaaag gcaagcctga 21601 gcatgtacac acactgaacg gctcaggact ggcggttgga agaacagttg ctgctatctt 21661 agaaaattat cagcaggaag acggaagcgt tgtgattccg aaagtgcttc gtccttatat 21721 ggggaataga gaagtaatga aaccgtaaat tatggaaagg cgtgcctgac aaggtgcgcc 21781 tttttgctta tgtaaacacg gcattttcat aaaaacaaaa aaagttttta aaaatgcttg 21841 accacacgag aacatacgtg atatagttag tcttgtcgat acggaggaat acccaagtcc 21901 ggctgaaggg atcggtcttg aaaaccgaca ggggtgtcaa agcccgcggg ggttcgaatc 21961 cctcttcctc cgccatattg attttaattc taatgaaaca caagcatata ttggagattg 22021 ttttgtccgt tgcattcggt gcggcggatt ttttatttta aagaaaaagt gaatctcgac 22081 tgagattcac tttttttgat tatcatgaat aactgaagca atttgatcta caatattttc 22141 aatcgagttt tcgtcgttca gaagatcata atcttcaatg cgaagtttta aaacagggca 22201 ggcattaaaa ccgcttatcc agttctcgta gcgtgtatgc atttcttccc aataagaccg 22261 gcttgtctga agctccatct cacggccgcg ttgttcaatc cggtttaaaa tgttctccag 22321 atctccttct aaatagatca acacatctgg atgtgggaaa tacggtgtca ttaccattgc 22381 ttcgaaaagg cttgtgtaag tcttataatc aacctttgac attgtccctt tatcagcatg 22441 catttttgcg aaaattcctg tatcttcata aatcgaacga tcctgtacaa aacctccgcc 22501 ggcttcaaaa attgttttct gttctttgaa gcgttcagct aagaagtaaa tttgaaggtg 22561 aaagctccaa cgttcaaaat catgatagaa cttttccaaa tatggattat gatcgacttc 22621 ctccaacgat gttttaaatc caagccgttt agctaaagtt tttgttaaag tcgattttcc 22681 gacacctact gttcctgcta ctgtaataat tgaattctta gggatatgat gttccttcat 22741 acgataagct cctttacatg ggcggcaatg cgttcaaagt cgctcttatt caaaacgaaa 22801 tcctttgaat caccatctac ggttaacact gtaagttcag ggtctgcttc ctgcagctgc 22861 ttgatggcga cttcataatc tgaaatcagc tgctccaaat agctagtttc aatttttttc 22921 tcaaaggggc gcccgcgttt ttcaatgcgg tgtagcaatg taggcagact ggcctttatg 22981 taaatgatga aattcggctt tggcagatca tccgttagca ggtgatatat ctttttgtat 23041 ttttccagct gatgtggaga caaggttcgt tccgcaaaaa tcacattttt ataaatatga 23101 taatcagcta ttacaggctg tccctttttt aaaaagtgat cactggtgtc ttcaagctgt 23161 ttgtatctgt gacaaagaaa aaacatctcg agctggaagc tccattcctt tatattgtca 23221 taaaacttat caaggtacgg gttatcctct acaatctcat tgatcatagg gaatccgaat 23281 ttttgtgaga gcatcgttgc gagagttgtt tttcctgccc cgataggacc ttctattgca 23341 ataaaagggg ctgtattcat cggaatcctc cttatatctg aaaaacgtgc gtcagttacc 23401 gaccttcata ttgtatcaca acccttgggt gcccccatga aaaaaagacg tttccaaatt 23461 atcgaaacgt ctttttgaca acattaaatt gatcagacag cagcagccag ttttgtggaa 23521 aggaaagacc cagcttccaa tagctgatgc ctcttaaatt cagctcttta atcagattga 23581 attttgcttg aatcgagcgg gcatcctcga accatacctc gtgccttctg ttttctgcat 23641 cagtatagcg gaagaaagga gcttgagcgg tttggtcata ctgaatggaa gcattgttct 23701 gatcagctat gacaatggct tgctgagggc ttactgctct tgctggagtt ccccctgctg 23761 tatatggcag cgtccagtca tatccatata aattctggcc catgacaatt ttgttcgcag 23821 gcatttcagt caaagcatat tctatgacat cacggacagg tccaattgga gaaaccgctt 23881 gaggcggtcc gccgctatag ccccattcat atgtcatgag aacaacaaag tcgacaattt 23941 cgccatgtgc cctgtaatca tgagcttcat accacctgcc ctgctgtgtt gcacttgttt 24001 taggagcaag agccgtagaa atttctaagc cctctcgatg gaaaagatcc cttgcttcgc 24061 ggaggaattg attataggcc tctctatcct ggggccgcaa atattcaaag tcgaaatgaa 24121 tgtcacggaa gccatatctt ctggcattct cgactatttc atttagaagc cgtcttttta 24181 cagtttcgtc gttcaaaagg atccggccaa gttcatcgct gaatgcctgg ttttctaggt 24241 tcgttataat catcatcaat gttgtatttt gactttctgt aatgctcctt aaattcgtta 24301 aaggcggtgc gactaaggtt ccgttccgct gtgcctggaa gctgaatgcg ccaaggtaag 24361 ttaagtaggg cgacgcttct ctggccgcct gctggagatt ttcgctgact tgatttcctc 24421 ggggctccaa ataagcattt gattcgatgt ctcgtttagg agctggaggg atgtataaac 24481 ggaaaccaat ctgaagcacg gtatttaact ggatgcggtt aacccttgcg agctcggctg 24541 ctgttgtatt gaactgccgg gcgatggatg tcagggtatc acctcgcttc acatcataga 24601 actggccagc tattggaatg acaatggttt gtccgacaac aaggctgtcg ggattcggta 24661 tttcattcgt ttcagtgatg tcatttgtgg ttgttctgta ttgtgaagcg atagcagaaa 24721 gagtgtcgcc ttgttttacc acataaattt gaatgaaaaa cgcctccttt catatcgcta 24781 tcaatgtatg aaagaaaagc gctgatcatg tttatttttc tataatttgt tcttccgtcg 24841 taatttctgc gaaaagaaca ttctccatca tggttaaggc gaattcgtta tcttcgtcac 24901 tgtttgacgc gatacagtcc ttaggaatcg tgatgctgta ttccctcata taagcgtcat 24961 tagcggtaaa cagcacgcat atattgccgg ctatacctgt tatgataata tgtctcacct 25021 gcaactcagt aagaagggtg tgaagtgctg tttcgtagaa agcggaatgt ttcggtttga 25081 ttaaaaaata atcagcatct accggagcta tctttgtgat gatatccttg cttctttcat 25141 ttgtgcattc ttgctgtatg tttttaatgt cagcttgcca aagtccataa tgatcattga 25201 tgtaaataat cggccattca ttttgtctcg cgtgctcctt taatgataaa atatgaggaa 25261 cgattttttc tgttttttta gcgagggttt cccccatatc gaattcaaaa ttattgatca 25321 tgtctacaat gagaagggct ttatctgctt tggacaatcg acagtctcct ttccgtttca 25381 gttatagtta atatgtagcc tttttaggca atgaaaaaac tttgaaaaga gagcttatcc 25441 ttatgacaca agatgaactt tatatgaaag aagcaattaa agaagcgaaa aaggctgaag 25501 agaaaggtga agtgccaata ggtgcggtgc ttgtcattaa tggtgaaatt atagcgcgtg 25561 cgcataattt aagagagact gaacagcgat ctattgccca tgcagaaatg cttgtaattg 25621 atgaagcgtg taaggcactc ggaacatggc ggctggaagg tgcgactctt tatgtgacgc 25681 ttgagccttg tccaatgtgt gctggtgcag tcgtactttc tcgagtggaa aaagtggttt 25741 ttggcgcatt tgatccgaaa ggcggctgtt caggcacgct aatgaacctt cttcaggagg 25801 aacgctttaa tcatcaggct gaagtggtga gcggtgtgct tgaggaagaa tgcggcggaa 25861 tgctcagtgc gtttttcaga gaactaagaa aaaagaagaa agccgccagg aaaaacttgt 25921 ctgaatagta cggttgcaat ttttagggga aacagatata cttaagtgtg catcgtaata 25981 gatgcaacat aaaatttgat atttattttg ccgtgctaag cggggaggta gcggtgccct 26041 gtacctgcaa tccgctctag cagggccgaa tcccttctcg aggttcgttt actttaaggc 26101 ctgccttaag taagtggtgt tgacgtttgg gtcctgcgca atgggaattc atgaaccatg 26161 tcaggtccgg aaggaagcag cattaagtga aacctctcat gtgccgcagg gttgcctggg 26221 ccgagctaac tgcttaagta acgcttaggg tagcgaatcg acagaaggtg cacggtaaat 26281 caatcatcaa attttcagac tcacctaata ttaggtgagt tttttgttat gtaaaaagag 26341 cttttggaat cgaaacaagg ttcatgtata atgggaatga tgaataacgg aggagggcaa 26401 acccgtgagt taccaagctt tatatcgagt attcaggcct cagcgctttg aagatgtggt 26461 cggacaagaa cacattacaa aaacgctgca aaatgccctt ttgcaaaaaa agttttctca 26521 cgcctatctg ttttccgggc ctagaggaac cggaaaaacc agtgcagcca aaatatttgc 26581 taaggctgtc aactgtgaac atgctcctgt tgatgagcca tgcaacgaat gtgcggcctg 26641 taaagggata acaaacgggt caatatccga tgtcatagaa attgacgccg cttctaataa 26701 cggtgttgat gagattcgtg acattcgcga taaagtgaag tttgccccat cggccgtcac 26761 atataaggta tatatcatag atgaggtgca tatgctttct atcggcgctt ttaatgcatt 26821 actaaaaaca ttagaagagc cgcctgagca ttgtattttc atattagcaa caactgaacc 26881 gcacaaaatt cctttaacca ttatctctag atgtcagcgt tttgacttta aacgaattac 26941 ctcccaagcg attgtaggcc gcatgaataa aattgttgat gctgaacagc tgcaagtgga 27001 ggaaggatcg ctggaaatca tcgcgagtgc tgcagacgga gggatgaggg atgccctgag 27061 ccttcttgat caggccatat cattcagcgg cgatatcctg aaagtcgaag atgcgctttt 27121 aattacgggt gctgtttctc aattatatat cgggaagctt gcaaaatccc tgcatgataa 27181 aaacgtttct gacgcactgg aaacattaaa tgaattgctt cagcaaggaa aagatccagc 27241 taagctgata gaagatatga ttttctattt cagggacatg ctgctgtaca aaacagcccc 27301 tggcttagag ggagtgcttg agaaagtaaa agtcgatgaa acgttccggg aactaagtga 27361 acaaattccg gctcaggccc tatatgaaat gattgatatt ctgaacaaga gccatcagga 27421 aatgaaatgg acaaatcatc cgcgtatctt tttcgaagtg gccgttgtga agatttgcca 27481 aacctcacat caatctgctg ctgatctccc ggaagtggat atgctgatga aaaaaatcca 27541 gcagctcgaa caggaagtag agcggctcaa aacaacgggc ataaaagcag ctgcggaaag 27601 cccgaaaaaa gaagcgccgc gtgtgccaaa gggcgggaaa tccaattaca aagcgccagt 27661 aggcagaatt catgagattt tgaaggaagc cacaagaccg gatcttgatc tgctcagaaa 27721 cagttggggc aagcttcttg ctcatctcaa acagcaaaac aaagtatcac atgccgcttt 27781 gctgaatgac agtgaacctg tggctgccgg atcggcggca tttgttctga aattcaaata 27841 tgaaattcat tgtaaaatgg tcgctgagga taacaacgga gtccggacta atcttgagca 27901 gattttagaa tcgatgctcg gaaaaagaat ggatttgatt ggcgttccag aagcacaatg 27961 gggtaaaata agagaagaat ttttagaaga tcatcagcag gaaaatgaag gatcaaatga 28021 accggctgaa gaagacccgc ttattgccga agcgaaaaag cttgttggag cggatttaat 28081 tgaaataaaa gactaacaaa atgaaagaga gtgaatgcta tgcgtggcgg aatgggtaat 28141 atgcaaaaaa tgatgaaaca aatgcaaaaa atgcaaaagg acatggcgaa ggctcaagaa 28201 gagcttgcag aaaaggttgt tgaaggaact gcaggcggcg gtatggtaac agtaaaagca 28261 aacggccaaa aagaaatcct ggatgttatc atcaaagaag aagtcgttga tcctgaagat 28321 attgatatgc ttcaagattt agtgcttgct gcaacgaatg aagctttgaa aaaagttgac 28381 gaaatcacaa acgaaacaat gggtcaattt acaaagggaa tgaacatgcc aggtttattc 28441 tagggggata aaagaacatg caatatcctg aaccaatatc aaagctgatt gacagcttta 28501 tgaaattgcc agggatcgga ccgaaaacag cggttcgtct ggcttttttt gttctaggta 28561 tgaaagaaga tgtagtatta gattttgcga aagcattagt aaatgcgaaa cgcaacctga 28621 catattgttc agtttgcggg catattacag atcaggaccc ttgctatata tgtgaagata 28681 cgcgcaggga taagtctgtt atctgtgttg tgcaagaccc taaagacgtt atcgctatgg 28741 agaaaatgaa ggaatacaac ggacagtatc acgttcttca cggcgctatt tctccaatgg 28801 acggcatcgg accggaggat attaaaatac cagaattgtt aaaacgatta caggatgatc 28861 aagtgacaga agtgatcctc gcgacaaacc ctaatataga aggggaagca acagcgatgt 28921 atatatcaag gctcctcaag ccgtctggta ttaagctctc ccgtattgcc cacggactgc 28981 ccgtcggcgg tgatttggaa tatgctgatg aggtcactct ttctaaagca cttgaaggaa 29041 gacgtgaatt gtaaggagga aaaagcgatc catgggtttt cttcgcaaga aaacattaag 29101 aagagagttt gatgaaaaac taaccgagca gctttttaag caaaaggaag agtggaacag 29161 gcaaaaaaag ctggttgaaa aaagcttaga accgtctgct gaagtgttat acgaactgaa 29221 agtagctgaa gcgaagtatt ttttttactt aagggaagcg aagcagcgaa atttaaaaat 29281 cagccggtgg aagtaagtgg tctaaactcc tggatcttct cataagcttg tactagaaca 29341 agcgaaggag atgagaagat tcatggagcc tatttttatt attgggatta ttttaggact 29401 ggttattctt ctttttttat caggttcagc agcgaagcct ttaaagtgga ttggcatcac 29461 agctgttaaa tttgtggcag gtgctttgct gctggtttgt gtaaatatgt ttggcggcag 29521 tcttggcatt catgtgccga ttaatctggt tacaacagct atcagcggaa ttttaggaat 29581 acccggaata gctgcgttag tcgtcattaa gcaatttatc atttaattga tattatgtat 29641 tgacttagac aactgaaggt gttattctaa tatacgtcgc tgatgacgaa cagctttttt 29701 gaaaagaaaa tgctaaaaag ttgttgacag tagcggcggt aaatgttatg ataataaagt 29761 cgcttaaacg agcggtaaac aaagttcttt gaaaactaaa caagacaaaa cgtacctgtt 29821 aattcatttt tataaatcgc acagcaatgt gcgtagtcag tcaaactact ttatcggaga 29881 gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa gtcgagcgga 29941 cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg tgggtaacct 30001 gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt tgtttgaacc 30061 gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc cgcggcgcat 30121 tagctagttg gtgaggtaac ggctcaccaa ggcgacgatg cgtagccgac ctgagagggt 30181 gatcggccac actgggactg agacacggcc cagactccta cgggaggcag cagtagggaa 30241 tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga aggttttcgg 30301 atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg gtaccttgac 30361 ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 30421 gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct taagtctgat 30481 gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt gagtgcagaa 30541 gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag gaacaccagt 30601 ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg gggagcgaac 30661 aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt tagggggttt 30721 ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta cggtcgcaag 30781 actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt ggtttaattc 30841 gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta gagataggac 30901 gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga 30961 tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc attcagttgg 31021 gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg tcaaatcatc 31081 atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag ggcagcgaaa 31141 ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt ctgcaactcg 31201 actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg aatacgttcc 31261 cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga agtcggtgag 31321 gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga agtcgtaaca 31381 aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat tttacggaat 31441 ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt gaaggaactt 31501 tgttccttga ataagttaag atgggcctgt agctcagctg gttagagcgc acgcctgata 31561 agcgtgaggt cggtggttcg agtccactca ggcccaccat cttatataac ggggccttag 31621 ctcagctggg agagcgcctg ctttgcacgc aggaggtcag cggttcgatc ccgctaggct 31681 ccaccaacgt gttctttgaa aactagataa cagtagacat cacattcaat tagtaacaca 31741 agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg gtggatgcct 31801 tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg agctgtaagc 31861 aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg agtggtatcc 31921 atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat ctaagtaccc 31981 ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg gattagccca 32041 aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac aaaggaacga 32101 ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt agtcaaaact 32161 tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg tcggaatccg 32221 ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc agtaccgtga 32281 gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc gtgtgcctac 32341 aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa ccggcgagtt 32401 acgatcccgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga gtctgaatag 32461 ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt ccagggtgaa 32521 gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc ggggatgagg 32581 tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc cgaaatagct 32641 ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac taggggcccc 32701 taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt gggagtcaga 32761 ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag ctaaggtccc 32821 aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga tgttggctta 32881 gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact ctgcgccgaa 32941 aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac agtggtagga 33001 gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt agaagtgaga 33061 atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc ctaaggtttc 33121 ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg aaaggcgtag 33181 gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc aatgggggga 33241 cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt aggctgggaa 33301 ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata tagtagcgaa 33361 gttcctgatt ccacactgcc aagaaaagcc tctagcgagg tgagaggtgc ccgtaccgca 33421 aaccgacaca ggtaggcgag gagagaatcc taaggtgatc gagagaactc tcgttaagga 33481 actcggcaaa atgaccccgt aacttcggga gaaggggtgc tctgttaggg tgcaagcccg 33541 agagagccgc agtgaatagg cccaggcgac tgtttagcaa aaacacaggt ctctgcgaag 33601 ccgtaaggcg aagtataggg gctgacgcct gcccggtgct ggaaggttaa gaggagcgct 33661 tagcgtaagc gaaggtgcga attgaagccc cagtaaacgg cggccgtaac tataacggtc 33721 ctaaggtagc gaaattcctt gtcgggtaag ttccgacccg cacgaaaggc gcaacgatct 33781 gggcactgtc tcaacgagag actcggtgaa attatagtac ctgtgaagat gcaggttacc 33841 cgcgacagga cggaaagacc ccgtggagct ttactgcagc ctgatattga atgttggtac 33901 agcttgtaca ggataggtag gagccttgga aaccggagcg ccagcttcgg tggaggcatc 33961 ggtgggatac taccctggct gtattgacct tctaacccgc cgcccttatc gggcggggag 34021 acagtgtcag gtgggcagtt tgactggggc ggtcgcctcc taaaaggtaa cggaggcgcc 34081 caaaggttcc ctcagaatgg ttggaaatca ttcgcagagt gtaaaggcac aagggagctt 34141 gactgcgaga cctacaagtc gagcagggac gaaagtcggg cttagtgatc cggtggttcc 34201 gcatggaagg gccatcgctc aacggataaa agctaccccg gggataacag gcttatctcc 34261 cccaagagtc cacatcgacg gggaggtttg gcacctcgat gtcggctcat cgcatcctgg 34321 ggctgtagtc agtcccaagg gttgggctgt tcgcccatta aagcggtacg cgagctgggt 34381 tcagaacgtc gtgagacagt tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga 34441 gctgtcctta gtacgagagg accgggatgg acgcaccgct ggtgtaccag ttgttctgcc 34501 aagggcatcg ctgggtagct atgtgcggac gggataagtg ctgaaagcat ctaagcatga 34561 agcccccctc aagatgagat ttcccattcc gcaaggaagt aagatccctg aaagatgatc 34621 aggttgatag gtctgaggtg gaagtgtggc gacacatgga gctgacagat actaatcgat 34681 cgaggactta accacatttt gaatgatgtc acacctgtta tctagttttg agagaacacc 34741 tctctaaagg cggaaggtaa ggaaactccg ctaagggctc tcacatcctg tgagaaacgc 34801 ccagtacctt catcctgaag gcatttgttt ggtggcgata gcgaagaggt cacacccgtt 34861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 34921 gtgagagtag gacgccgcca agcaagctta aacccagctt aatgagctgg gttttttgtt 34981 tactcaagat cgagaaaatc aaacaaatac aaacaccgag ggcttatata gcccatatac 35041 tgatttaaag tttcaaaaag gtctaaatag tgtatacaat atccgtttta aggggaggct 35101 aactgtacgg aggtggagaa gatggacgaa acagttaaac ttaatcatac atgtgtgatt 35161 tgtgatcaag agaagaatag aggcattcat ctttatacga aattcatatg cttagattgt 35221 gagagaaaag taatttctac atcaacttct gatcctgact atgcgtttta cgtaaaaaaa 35281 ctaaagagca ttcatacacc gccattatat tcatagacct gaaaaggtct ttttttgtac 35341 tcttaataat aaaaagaaga tgaaacttgt ttaaggattg aacgtagtag ataataatat 35401 taaaactgag tatagacaca ggagtcgatt atctcatgca gagatttttt cactttttgg 35461 tgtggagttt aactagcagt gcgacttttg ttttcattgg aatattgagc ttttttggtt 35521 taaaccagtc gattttttta tctattgttt atgggcttgc ttctggagca gccgtatata 35581 tagctggcat ctggaatgca agacggttat ttcttaaaaa gcatgaattg acaggaagag 35641 agtatgctta cattaagaaa aacttagagg aagcaaggca gaaaatggtc cgtcttagga 35701 aagccttgtt tcaggctaaa agcattcaaa tgtttaagca aaatgcagaa atgctaagga 35761 ttgtgagaag gatttatctc ctcaccaaaa aagagccaaa gcggttttat caggcagaac 35821 gattttttta tcaaactctc gattcggttg ttgaattgac agagaagtat gcttttctat 35881 catctcaccc aaaaaaaagc aaagaactgt cgatgtcgtt aagtgagaca cgcatcactc 35941 ttactgaatt gaccaagcgt ttagaggaag atttaactca agcaatgggt gatgaaattg 36001 acgagttgca gtttgaatta gacgcagcaa aacattcatt aaagaaataa gggaagaggg 36061 taagagcgat gaaccgagac caaagcgacc ttcatataga tgaattattg gcagatcctt 36121 ttggtggtaa catagagata ccaggttcgg aggctgtaaa agcagagaaa gagcaagtac 36181 ggcttgttga tgttcttcct gaggaaaaca aggaaaaagc aattcagctt gctggacaga 36241 ttgatcataa aaatatgcaa agcattgtct tatacggttc acaagctcaa tctaaactgc 36301 tgaacttttc tcatgatatg attaatcatg ttcaaaagaa ggatgtcggg gagattggcg 36361 aaatacttgg agagctgatg aaaaagctgg agcaagtaaa tcctgatgat ctccaatcta 36421 agaaaaaggg ttttttggca cgcatgtttg gaagagtatc aagttctctt caagaggtgc 36481 tgtctaaata ccaaaagacc agtgtgcaga tagacagaat cagcttgaag ctggagcact 36541 ctaaaaatgc tttaatcagt gacaacaagc tgttagagca gttatatgaa aaaaataaag 36601 aatatttcgc agcgctgaat gtttatattg ctgcaggaga actgaagctg gaggaattaa 36661 aaacaaaaac gattcctgaa ctgaagcaac aggctgaatc gagtgatcat aaccaaatgg 36721 ccgttcaaga ggtgaatgat ttaattcaat ttgctgaccg gttagataaa agggtgcatg 36781 atttgctgct gagcaggcaa attacaatcc aaagtgcacc gcaaatcagg ctgattcaaa 36841 atacaaacca agcgttagct gaaaagattc agtcatccat tgtgacagcg attccgttat 36901 ggaaaaatca agttgccatt gcactgacgc ttttaaggca gcgcaatgca gtggatgcac 36961 agcagaaagt atctgataca accaatgagc ttttgctgaa aaatgcggag cttttaaaaa 37021 ccaatacaat tgaaactgca cgggcaaatg aaagaggcct tgttgatata gataccttga 37081 agaaggtgca ggaaagctta ataagcacgc ttgaagaaac actgactata caagaagaag 37141 gacgaatcaa acgccgtcag gcagaagaag agctcatgat gatggaaggc gacctgaagc 37201 aaaagctgat tacaataaag gaaagatgat taccagtaag tctggcttta agttctgtca 37261 gaggcacgat ataataaggt gtaagaagac acattcaaag gattgttttc atgaacacac 37321 ctttatataa agcattaatt caacatgcga gaagaaattc tcattcattt catgttccgg 37381 gacatcacaa tggagatgtc ttttttgatg acgctaagtc aatattcgat ccgcttctca 37441 ccattgatgt aactgaactg gcaggactgg atgatctcca tcatccttct ggggtgatta 37501 aggaagctca ggagcttgcc agtcaattat atggatcggc ggaaagtttt tttctggtaa 37561 atggtacgac tgtcggaaac ttagcgatga ttttatctgt ttgtgaacct ggtgatacaa 37621 ttctggttca aagaaactgt cataaatctg tatttcatgc tgttgatttg tccggtgctg 37681 agccggttta tcttgcacct gacgttgatt cagcgatgca tgtgcctacg catgttccgc 37741 ttggaacaat taaagaggcc ctggaagcat atccagatgc gaaaggcttg gtactgacca 37801 atccgacata ttacggacat agtgctgatt tgactgagat cattactgaa gcccatcatt 37861 acgggattcc tgttttggtc gatgaagcgc atggcgcaca ttttatttta ggtgagcctt 37921 ttccggtctc agctttaaaa atgggggcag atattgttgt tcagtcggcc cacaaaacgt 37981 tgccagccat gacgatgggt tcttatttgc atctcaacag cagctgcagg attaacaggg 38041 atcgggtggc agagtattta aaccgattac aaagcagcag cccgtcttat ccgattatgg 38101 cttcgttaga tattgcccgc gcttatgtac agcatattat agaagaacaa aagctttctg 38161 acattctgca gcggatagaa acacttaaac aaacgtttga ttcacttaca aatgcagaag 38221 ctgttaaccc tgctaatcca ctgatcatca cggatccgct aaagctcaca attcgttcaa 38281 aacgcgggca ttctggctat acgctgcaaa gcattttaga gcgtgccaac atattcactg 38341 agcttgctga tgaaaatcaa gttctgctcg ttctcccatt gggaggaaaa cggagaataa 38401 acgctgaaat cattagaagc atcgatgaag agattgagaa aacgcctccg gatcagacgt 38461 ttgtttctgc agaatggggt gtgcagcctg ttactgtctt gccttatcca aaaaaggtct 38521 tacattcgtt taagaaagaa tatgtgagct ttgaggaagc agctggccgg cttaatgcag 38581 aagatatcat cccttatcct ccgggtatcc cgatgattat ggcgggagaa agaataacaa 38641 aagaaagtgt gcaaaagctc agccgcttga tcagcatgaa aacgcatgtt caagggaata 38701 tgaaaatcaa agagaaacaa ctacttgttt atatagaaga ggagaaatca tgagcggttt 38761 atttattaca ttcgaaggtc ctgaaggtgc agggaaaacg actgttctgc aggagatcaa 38821 aaacatactg acagcagaag gccttcaggt tatggcaact cgagagccag gcggaataga 38881 tattgcagaa caaattagag aggttattct gaatgagaac aatatattaa tggacccaaa 38941 aacagaagct ctcttatatg cggctgcaag acgccagcat ttagttgaaa aagtaaaacc 39001 tgctttagaa caggggttta tcgttctttg cgacagattc atagacagtt ctcttgcgta 39061 tcaaggatat gcaagagggc ttggaattga tgaggttctg tccattaatg aatttgccat 39121 tggagatatg atgccccatg taacggttta tttttcaatt gatccggaag aaggactgaa 39181 gcgtatttac gcaaacggct cacgggagaa aaacaggctc gatttagaaa aactggactt 39241 tcatacaaaa gtacaagaag gttatcaaga gctgatgaag cgatttccgg aaagatttca 39301 ttcagttgat gccgggcaat ccaaagacct cgtcgttcag gatgttctaa aggtgatcga 39361 tgaagcgttg aaaaaaattc aattgtgacc tgtttcccaa tagttgatat aataatgtaa 39421 acgagatcac gttgtttcca atctaaagga ggccttcaca gatgaaattg atagtggcag 39481 ttgtacaaga tcaggacagc aacagacttt tgaaaacctt aacggatcac aacttcagag 39541 tcacaaagct tgcaacgaca ggaggatttc ttaaatcagg caatacaacg tttatgatcg 39601 gtgtcgagga tatacgcgtc aataaagcgt tgagtctcat taaagaaaac gggcagaaac 39661 gtgatcagat gattgcccct gtatctccaa tgggtggaaa tgctgattcc tatgtccctt 39721 atccagtcga agttgaagtt ggcggagcga cagtatttgt ccttccagtc gatgaatttc 39781 atcaatttta aggatctgaa actgtgaaaa ttaataaaga tatacgtaca tttatagata 39841 ataagcagat tccctctgtg aaaacatctg agatcacagc atcgtttaaa acatcaatgg 39901 aaaaccaaag cagcaaaatg aagcttgatc agcttaccag gctgttatct gatatagaag 39961 catttggaaa aaggctaacg aaatctcgga attttaaaga cttagcgaga tttaaaggac 40021 ttgtgaaacg ttttgtcaaa gaagctgtgg acagcggtct ttcacatgaa acatcgaaaa 40081 gctttgacct ttacgggaac agcagaacgc tgggacttgt gaaagaaata gatgacaaat 40141 tgatacagct tacggaagag atgatggatc aggaaaaacc ggcaattgat ttgctggagc 40201 gtattggcga aataaaaggt ttattaatta acctttacac atagagagtg atacaatggc 40261 aatatcctgg aaggaaatga acgagcttca gcccagagtg atgaagcttt tatataatag 40321 tattgagaag gacagactat cacacgctta tttgtttgag gggaaaaaag gaacaggcaa 40381 gcttgatgcc gcgctgcttc ttgcaaaaag cttcttttgt ctggagggtg gcgcggagcc 40441 ttgtgagagc tgccgaaact gtaaacggat agagtcaggg aaccatcctg atctccatct 40501 tgttcagcct gatggcttat caatcaaaaa ggcgcaaatt caagcgctcc aagaagagtt 40561 ttctaagaca ggacttgaat cgcataaaaa gctgtatatt atttcgcacg cagatcaaat 40621 gacagcaaat gcggcgaaca gcctgctgaa atttttagaa gaaccgaaca aagacacaat 40681 ggccgtcctc atcactgagc agccccaaag gttattggat accatcattt caagatgcca 40741 aacccttcct tttcagcctt tgcagccgaa agcaattgaa gacagactga tcgaacagga 40801 cgtctcgcct catatggcaa ggcttctggc caacatgact aataatgtag cagaagcagt 40861 cgaattaagt cgaaatgatg agtttgcaga gtctagagcg aaagtgataa aattgtatga 40921 agtcctacac cagcggaaag gacatgcttt tttctttatt caagatcaat ggatgccctt 40981 tttcaaagaa aaaacccatc aagaaatggg tcttgatatg ctcttattga tatatcgtga 41041 tgtgttgtcc atccaaatag gaaatgaaga taaattgatt tatcaagact tattccaatc 41101 aataaaacag catgcgctac aatcaacaca acaaagcgtt acgaatcaga tacttgctgt 41161 tttagaagca aagaaacggc ttcattccaa tgtgaatgta caaggattaa tggagcactt 41221 ggtgttaatg ttgcaggagg gataagcttg tacaatgtaa ttggtgtccg ctttaagaaa 41281 gcgggtaaaa tatattattt tgatccgaat ggatttcata tagaacatga cagctgcgta 41341 attgtagaaa ctgtcagagg cgttgagtac ggccaggtcg taattgcaaa taaacaggtg 41401 gatgagcatg atgtggtgct tccccttcga aaagtgatac gtgtggcaga cgatcgcgat 41461 cttctcattg tagaagaaaa taaacaggaa gcactatcag catttgatat ctgccaaaag 41521 aaagtgattg agcatggctt ggatatgaag ctggtcgatg ttgaattcac gtttgatcgc 41581 aataaagtca ttttttactt cactgctgac ggccgagtcg actttagaga gcttgtaaag 41641 gatttggctt ctatctttaa gacaagaatt gagctgcgcc aaatcggagt gagggatgag 41701 gcaaaaatgc tcggaggaat cggtccttgc ggaagaatgc tttgctgttc aacgtttctt 41761 ggagattttg aacccgtttc cattaaaatg gccaaggatc agaacttgtc tttaaatcct 41821 acgaagattt cgggtctttg cggacgattg atgtgctgtc taaaatatga gaacgatgag 41881 tatgagacgg caaaagaaca gcttccggat ataggagaaa tgattacgac agcaaacggt 41941 cccgcgaagg tcgtcggact aaatattctg gaacgggtgc ttcaggtgga actgataaac 42001 cgtgaaaaag tgatagaata tacttgggaa gagctcttgg aagagggcgt cgtatccgca 42061 caaaccacag attaacgagg tgtggaacct tggataaaaa agagttattt gatacagtca 42121 ttaacttaga agaacaaatt ggctcactgt accggcagct gggggatttg aagcagcata 42181 tcggtgagat gattgaggaa aatcatcatt tacagcttga aaacaagcat ttgcgcaaac 42241 ggctggacga tacgacgcag cagattgaaa agttcaaagc tgataaaaaa gaatcaaaaa 42301 cacagaagac agagcaaact gatatagggg aaggatatga taatctggca cgtctgtatc 42361 aagaaggatt tcatatctgc aatgtccact atggaagtgt tcgaaaagag gattgtcttt 42421 tctgtctgtc attcttaaat aaaaaatagg gaaaaggctt ccgcataaga cgggagcctt 42481 tttcaaaggt actgaaagga taagaagatg gtttcattac atgatgatga aagattagat 42541 tatttgctgg cagaggacat gaaaatcata caaagcccaa cagtgtttgc tttttcgttg 42601 gacgctgtgc ttctgtccaa atttgcgtac gttccgattc aaaaagggaa aattgttgat 42661 ttatgcaccg gcaatggtat tgtgccgctg ctgctcagta caagatcaaa agcagacatt 42721 ctgggagtcg aaattcaaga aagactgcat gatatggctg ttcgcagcgt ggagtataat 42781 aagttggacg atcagatcca gatcatacat gatgacctga aaaacatgcc ggagaaactt 42841 ggacataatc gatatgatgt tgtcacctgc aatccgccgt attttaaaac gccgaaacaa 42901 actgaacaaa acatgaacga gcatctccga atcgcaagac atgaaatcca ctgcacgctg 42961 gaggatgtca tttcagtcag cagcaagctg ctcaagcaag ggggaaaagc agctcttgtt 43021 caccggccgg gaaggcttct ggagattttt gaactgatga aggcttatca aatcgagccg 43081 aaacgtgtac aatttgtcta tccgaagcaa gggaaagaag ccaataccat tttggttgaa 43141 ggtatcaaag gcgggcgccc ggatttgaaa attcttcctc ccttattcgt atatgatgaa 43201 caaaatgaat atacaaaaga aatcaggacc attttatatg gagacaaata accatttctt 43261 ctacgtcgtg aaatgtaagg acaatagctg gtatgccggg tataccaacg atctgcataa 43321 acgagtgaaa acgcacaatg atggaaaggg cgcaaagtac acaaaagtaa gacgtccggt 43381 tgaattaatt tttgccgaga gcttttcaac aaagcgggaa gctatgcagg cggaatatta 43441 tttcaaaaaa ctaactcgga agaaaaaaga gctttatata gaagaaaagc ggaacagcaa 43501 ggaggctgta tatgttaagg cgccaaatga gctttaatgg aaagtcggac atggggattc 43561 tttacttggt cccaacccca atcggaaatt tagaggatat gacattccgg gcgatcgaca 43621 cgctgaaatc agtggatgcg attgctgcgg aagatacgag gcaaacgaaa aagctttgtc 43681 atgtatatga aattgaaaca ccgctcgtca gctatcacga acacaataaa gaaagcagtg 43741 ggcacaaaat tattgaatgg ctgaaatcgg gaaaaaacat tgctcttgtc agtgatgccg 43801 gtctgccgac gatttctgat cccggagcgg aaattgtaaa ggattttacg gatataggcg 43861 gttatgttgt tccgttgccg ggagcaaatg ctgcattaac agctcttatt gcttcaggta 43921 ttgtaccgca gccttttttc ttttacggtt ttctcaacag acagaaaaaa gaaaagaaga 43981 aggagcttga agcccttaaa aaacggcagg aaacgatcat tttttatgaa gcgccccaca 44041 gattgaagga aaccttgtca gcgatggcag agatattagg agatcgggaa attgctgtaa 44101 cacgtgaact cactaagaaa tatgaagagt ttatccgagg aaccatatct gaggtcattg 44161 gatgggcaaa cgaggatcag atacgcggcg agttttgtct tgtcgtagaa ggaagtaata 44221 atgaagaggt agatgaggaa gaacaatggt gggaaaccct cactgcgaaa gaacatgtcg 44281 agcattacat ttcgaaaggc gctacgtcta aagaagctat taaaaaagca gcagtcgatc 44341 gcaatgtacc aaagcgtgaa gtgtacgatg cttaccatat taagcaataa aaaaacgttc 44401 ttgtgtcata acaagaacgt tttttgtaca agaaatgatt atttaaggtt ttgaagctgg 44461 ttttggattt cgctgatgat ttgctcagcg ccttctttac taagaaccaa tttaccgcct 44521 gcaagtttaa ggttatcatc agaaacttca ccagttactt ggcaagtcat gtttggttta 44581 tattttttaa ggatgatttt ttcatcatca acatagattt caagagcatc tttttctgcg 44641 attccaagag tacgacgcag ttcgatagga ataactacac gtcctaattc atcaacttta 44701 cgtacaatac cagtagattt cataaacatt ctcctcccaa gagatactta tttgtttaaa 44761 ttatattttt cttcgtcatt attcgacaaa atccttacct tcatagcata acaaggtttc 44821 caataatcgt caatcatttt gtttactatt gattgtaaga attagttctt atagtcagta 44881 atgtcttgga aactaccgaa ataacagcat tttataaata tttaataaag ctattatcct 44941 actaaaaatc cttttaaatc aagactttcg aaccaaagtt ttttatttca tttgattata 45001 tacgacaaaa ttcgacacga acagactttt tttattttca ttaaagattt ttaattttaa 45061 ttattctttt tcagggcgta tgtatatatt cttgatctta aaggctaaga tggtatcata 45121 gataaaggat aaatataaat aatattcata tatgatttgc acttatcgcc gctctcgtcc 45181 tttgggcggg agctttttga cattctgatt aggaggtttc aagatgccgc aagaaaacaa 45241 tacattttac attacaacac cgatttatta tccgagcgga aaattacata tcggccatgc 45301 atatacgaca gtcgcaggag atgcaatggc acgttacaaa agattaaaag ggttcgatgt 45361 tcgctattta acgggaacgg acgagcatgg acaaaagatc cagcaaaaag ctgaacagga 45421 aaacattaca cctcaggagt atgtggatcg cgcagcggca gatattcaaa aactgtggaa 45481 gcagcttgaa atctcaaacg acgactttat ccgcacgaca gaaaaacggc ataaagttgt 45541 cattgaaaaa gtgtttcaaa agcttcttga taacggggac atctatcttg atgagtatga 45601 aggctggtac agcatccctg atgaaacgtt ctacacggaa actcagctcg ttgatattga 45661 gcggaatgaa aagggagagg tcatcggcgg aaaaagccct gacagcggtc acccagttga 45721 attgatcaaa gaggaatctt atttcttccg catggggaaa tacgcggatc gtcttctgaa 45781 atactatgaa gaaaacccga cattcattca gccagaatca cgcaaaaacg aaatgattaa 45841 taactttatc aaacctggac ttgaggattt ggcagtatca cgtaccactt ttgattgggg 45901 cgtgaaggtg ccggaaaatc caaagcatgt tgtatatgtt tggattgacg cactatttaa 45961 ctatttaacg gcactcggtt atgatacaga aaatgatgag ctttatcaaa aatattggcc 46021 tgccgatgtt catttagtcg gtaaggagat tgtacgattc catactattt actggccaat 46081 tatgctgatg gcgctggatc ttccgctgcc aaagcaagta ttcgcgcatg gctggctttt 46141 gatgaaagac ggaaaaatgt cgaaatcaaa aggaaacgtt gtagatccgg ttacattaat 46201 tgaacgctat ggtttagacg aacttcgcta ttacttgctt cgcgaagtgc cgttcggatc 46261 agacggtgtt ttcacgccgg aaggatttgt tgagcgaatc aactatgatt tagcgaatga 46321 tttaggaaat ctattgaatc gtactgttgc gatgattaat aagtattttg acggacaaat 46381 cggttcttac aaaggtgctg ttacggaatt tgaccatacg ctcacttctg ttgctgaaga 46441 aacagtgaaa gcttatgaga aagcaatgga aaatatggag ttctcggtag cactttcgac 46501 tttatggcag ctcatcagcc gcacaaacaa atacattgat gagacagctc catgggtgct 46561 tgcgaaagat ccggcaaaag aagaagaatt gcgatcagtt atgtatcatc tcgctgaatc 46621 attgcgtatt tcagcggtac tgcttcagcc attcttaaca aaaacacctg aaaaaatgtt 46681 cgagcagctg ggcattactg atgaatcttt aaaagcttgg gacagcatta cagctttcgg 46741 ccagctgaaa gatacaaaag tacaaaaagg cgagccattg ttccctcgtt tagaggcaga 46801 agaagaaatt gcttacatca aagggaaaat gcaaggttca gcaccagcga aagaagaaac 46861 aaaagaagaa gagcctcaag aggtcgatcg tttacctgaa attacgattg atcaatttat 46921 ggatgtagag cttcgcgtag ctgaggtcat tgaggcagag ccagtgaaaa aagcagaccg 46981 tttattgaag ctgcagcttg atcttggttt tgaaaagcgc caagtggtat ccggcattgc 47041 gaagcattat acgcctgaag agcttgttgg aaaaaaactc gtttgtgtaa caaatctaaa 47101 accggttaaa ctcagaggag agctttctca aggtatgatc cttgcaggag aagcagacgg 47161 cgttttaaag gtcgtatcta tcgatcagtc gttaccaaaa ggcacaagaa ttaaataatg 47221 ataaacaaaa ggtgtttcac gtgtaacaat tcgtcgaaca ccttttgtgt ttcgacaaga 47281 aaggagtttt tcacttatgt tgtttgacac tcacgcgcat ttaaatgcag aacaatatga 47341 tactgatctt gaagaggtta ttgaacgggc aaaagctgaa aaagttgaac gaattgtcgt 47401 agttggtttt gaccgtccga cgattacccg tgcgatggaa atgattgagg aatatgattt 47461 tatttatgca gccattggct ggcaccctgt tgacgctatt gacatgacag aggaagactt 47521 agcgtggatt aaagagcttt ctgctcatga gaaagtggta gcgatagggg aaatgggact 47581 ggattatcat tgggataaat cacctaaaga tattcaaaaa gaggtgttta gaaatcaaat 47641 cgccttagcg aaagaggtca atttgcctat tatcattcat aaccgtgatg caacggagga 47701 tgtcgtgacc attttgaaag aggaaggcgc agaagctgtg ggcggaatca tgcactgctt 47761 tacaggaagt gcggaagtgg caagagaatg catgaaaatg aatttttatt tatcatttgg 47821 gggaccggtg acatttaaaa atgcgaagaa accgaaggaa gtagtgaagg aaattcccaa 47881 tgaccggctg ctgattgaaa cggactgccc gtttctcaca ccgcaccctt tccgcgggaa 47941 aagaaatgag ccaagctatg tgaaatatgt ggcagaacaa atcgccgaat taaaagaaat 48001 gacctttgaa gagattgctt ccatcacgac tgaaaatgcg aaaagacttt tccgtataaa 48061 ctgacaaaaa acgctagcgg gttttgtaag agcttgtccc ttacagcgtt tttctataaa 48121 agttctacat gctttcttct cctcatagga taggtttgtc gacaagtctt tcttccgttt 48181 ctcagtgtat ttcaggataa tgaagaggac actgagcttt tgggagaaag agaagggagg 48241 gttgacagcc ttttagatac tctatataat ctctccgagg agaaggaggc gtttttcatc 48301 acacaaaaaa tgaaaaagct gttttccgta aagcttagca aaagcaaagt cattctggtt 48361 gctgcttgtt tgcttttggc aggaagcggg actgcgtacg cggctcatga gctgacgaaa 48421 caatcagtct cagtttctat caatggcaaa aagaaacata tacgcacaca tgcaaataca 48481 gtcggtgatc ttttggagac gcttgatata aagacaagag acgaagacaa gatcacacct 48541 gctaaacaga caaagataac agcagacatg gacgttgtgt atgaggctgc aaaacctgtg 48601 aagcttacaa taaacgggga agaaaagacg ttatggtcaa cagcaaaaac ggtcggtgca 48661 ttactggacg aacaagatgt tgatgtgaaa gaacaagatc aaattgatcc cgcaatagat 48721 acagatattt cgaaagacat gaagattaac atagagcccg catttcaggt tactgtgaat 48781 gatgcaggga aacaaaagaa gatctggacg acttcgacta cggtcgctga ctttttaaaa 48841 cagcaaaaga tgaacataaa agacgaagat aaaatcaagc ctgcgttaga tgcaaagctg 48901 acgaaaggaa aggctgatat tacaattact cgtatcgaaa aggtcaccga tgtagttgaa 48961 gagaagattg cgttcgatgt gaaaaagcaa gaagacgctt ctcttgaaaa agggaaagaa 49021 aaggtcgtcc aaaaaggaaa agaaggcaag ctaaaaaaac atttcgaagt cgttaaagaa 49081 aacggtaaag aagtgtccag agagcttgta aaagaagaaa cagctgaaca aagcaaagat 49141 aaagtgattg ctgtcggcac aaagcaaagc agtccaaaat ttgaaacggt cagtgcttca 49201 ggtgattcaa aaacagttgt gtcccgcagc aatgaatcaa caggcaaagt catgactgta 49261 tcatctacgg cttatacggc aagctgcagc ggttgttcag gacatacagc gacaggcgtc 49321 aatttaaaaa ataatccgaa tgccaaagtc atcgctgtgg atccaaatgt cattccgcta 49381 ggctccaaag tccacgtgga aggctatgga tatgccattg ctgcagatac cggttcagcg 49441 attaaaggga acaagataga cgtctttttc ccagagaaat catcggcgta ccgatgggga 49501 aataaaacag tcaaaattaa aatcttaaat tagtatatac ttatgtattc agagggtttt 49561 gcgccctctg tttttttcgt tataatagac aaagtgcatt ttctgcttat tagacgctcg 49621 atataagaaa aagtttcatg aatatacaaa agtttttatt ttgtcttgga ggaaataatg 49681 aaaattaaag agatcattgt ggtcgagggg cgtgacgata cggcccgcat caaattggct 49741 gttgatgcag acacaattga aacaaatggt tcagccatcg atgatcatgt gattgaccaa 49801 atccgtttgg cccagaagac gagaggcgtc attattttaa cggatccgga ctttccggga 49861 gagaagattc gcaaaaccat ctcagaggct gtacccggct gtaagcatgc atttttgcca 49921 aaacatcttg ccaaacctaa aaacaagcgg ggaattggtg tggagcatgc atcggttgaa 49981 agcattaggg catgtttaga aaatgtgcat gaggagatgg aagcgcagcc gagtgacatt 50041 tcagctgagg atttgattca tgccggacta ataggcgggc ctgcggccaa atgccgccgg 50101 gaacgactgg gtgatctgtt gaaaatcggc tatacaaatg gcaaacagct tcaaaaacgg 50161 ctgcaaatgt ttcaaattaa aaaaagtgat tttatgagtg cgctcgatac cgttatgcgg 50221 gaggaacaga atgaataaag atattgcgac accgattaga acgaaagaga tactgaagaa 50281 atacggtttt tcttttaaaa agagcttagg acagaatttc ttaattgata cgaacatttt 50341 aaacagaatt gttgatcacg cggaagtgac ggagaaaaca ggtgtcattg aaatcggccc 50401 gggaatcggg gctttaaccg aacagcttgc caagcgggcg aaaaaggtcg tggcatttga 50461 gattgaccag cgattattgc cgattctgaa ggatacactg tcaccttacg aaaatgtcac 50521 tgtcattcat caggacgtgt taaaggctga tgtcaaatca gtcattgaag aacaatttca 50581 agattgtgat gagatcatgg tagttgccaa ccttccttat tacgtaacaa caccgattat 50641 catgaaactg cttgaagaac atcttccgct gaaagggatt gtggttatgc tgcaaaaaga 50701 agtggctgag cgcatggcgg ctgatccttc atctaaggaa tacggctcgc tttcaatcgc 50761 ggtgcagttt tatacagaag ccaaaacggt gatgatcgtc ccgaaaaccg tatttgttcc 50821 tcagcctaat gtcgattccg cagtcattcg tctgattctc cgagacggcc cggcagtgga 50881 cgtggaaaac gaatcctttt tctttcagct catcaaggca agctttgcac agcgccgtaa 50941 aacgctgctc aataacttag ttaacaatct gcctgaagga aaagcacaaa aatcaacgat 51001 tgaacaagtg ctcgaagaaa caaatattga cggtaagcgc cgaggtgaat ccctgtctat 51061 tgaggaattc gcagcgctgt ctaacggatt gtataaagcc cttttctaaa agggcttttt 51121 gttttgcgca ccacatggac tgccgctaca taggctagag aaggaccttt cattcaatga 51181 taagaaaaaa cttggactca gcgaaaaaag gcgctttctc aaggctcttt ctttcatgat 51241 gaggcttagt ctatgtgtgg agtgaggaac gtgcaatttc aaatagggga tatggtagcc 51301 agaaaatcct atcagatgga tgttttgttt cgaattatag gaatagagca aacaagcaaa 51361 ggaaattcaa ttgccatttt gcatggagat gaagtcaggc tgattgctga ttcggatttt 51421 tctgatctgg tggcagtgaa aaaggatgag cagatgatgc ggaaaaagaa agatgagagc 51481 agaatgaatg agtcgctcga attgctccgc caagattata agctgctcag agaaaagcag 51541 gagtactatg cgacaagcca atatcagcat caggagcatt atttccatat gccgggcaaa 51601 gtgcttcatc tggatggtga cgaagcatat ttgaaaaaat gcctgaatgt ctataaaaaa 51661 attggagtgc cggtctatgg catccattgc catgaaaaga aaatgtctgc ttctattgaa 51721 gtattgctcg acaaatatcg acctgacatc ctggtgatca cagggcatga tgcgtactcg 51781 aagcaaaagg gcggtattga tgatttgaat gcgtacagac attctaagca ctttgttgaa 51841 acagttcaaa cagcccgaaa aaagatccct cacttagatc agcttgttat ttttgcgggg 51901 gcctgccaat cccattttga atcactcatc agagcgggtg cgaattttgc aagttcaccg 51961 tcaagagtca atattcatgc gcttgatccg gtatatatcg tcgcgaagat cagctttacg 52021 ccgtttatgg aacggattaa tgtatgggaa gtgctccgta atacgctgac aagagagaaa 52081 gggcttggag gtattgaaac aagaggagtt ctgagaattg gtatgcctta taagtccaat 52141 taacagttga aaacctgcat aggagagcta tgcgggtttt ttattttaca taatgataca 52201 taatttaccg aaacttgcgg aacataattg aggaatcata gaattttgtc aaaataattt 52261 tattgacaac gtcttattaa cgttgatata atttaaattt tatttgacaa aaatgggctc 52321 gtgttgtaca ataaatgtag tgaggtggat gcaatggcga agacgttgtc cgatattaaa 52381 agatcgcttg atgggaattt aggtaaaagg ctgacgttaa aagcaaacgg tggccgccga 52441 aaaacgattg agcgttcggg cattttagct gagacgtacc cttctgtttt tgtgatacaa 52501 ctagatcaag acgagaactc gtttgaaaga gtttcataca gttatgctga tattttgact 52561 gagactgttg agctgacatt taatgatgac gccgcaagct cagtggcatt ttaacgggca 52621 gtgaaccttt tgtttactgc tttttgtttt gccctttttt ggtttccaat aattttaacg 52681 aaagttccat ctgatttaac aaaagataaa acagtcacat attatcgtga cgtgcacgaa 52741 tggctatcac ttctaaaaaa ggagttgttt cgtttgggca gacgtcgtgg agttatgtca 52801 gatgagttta aatatgagct ggctaaagac cttggttttt atgacacagt aaaaaatgga 52861 ggctggggtg aaattcgggc ccgcgatgcc ggtaacatgg tgaagcgtgc tattgaaatc 52921 gccgaacagc aaatggctca gaatcagaat aaccgataag gatgtgaccc gggggacgtg 52981 ctgttccctg gtttttttat tttggatata aatacataat gggctgaata tggatatgtt 53041 catcctgtac ttcaaatgtg atacaatgtt catacttatg tttagatgga gaagtaggtg 53101 aaagctatgc gtattttaga aaaagcgcca gctaagatca atctgtcact tgacgtcacc 53161 cgaaaacgcc cggatggcta tcatgaagtc gaaatgatca tgacgacaat tgatttagct 53221 gatcgaattg aattgacgga gcttgcagag gatgaagtga gggtttcctc ccacaaccga 53281 tttgtgcctg atgaccaaag aaacttagct tatcaggctg ccaagctgat caaggacaga 53341 tacaacgtga aaaagggagt ttccatcatg attacgaagg taattccggt ggctgccggt 53401 cttgccggcg gaagcagtga tgcggcggcg acactcagag ggctgaacag actgtggaat 53461 ttaaatctgt ccgcggaaac gcttgctgag cttggagcgg aaattggctc tgacgtttca 53521 ttttgtgtct atggcggaac tgcattagca acagggcgcg gcgagaaaat taaacatatc 53581 agcacgcctc cgcactgctg ggtcatttta gcgaagccga caatcggtgt ttcaactgct 53641 gaagtgtaca gagcgctgaa actggatggt atagagcatc ccgatgtaca aggcatgatc 53701 gaggcgatag aagaaaagag ttttcagaag atgtgcagcc ggttaggcaa tgtgcttgaa 53761 tctgttacac tcgatatgca tcctgaagtt gcgatgatca aaaaccagat gaaacgcttt 53821 ggtgcagatg ccgtgttaat gagcgggagc ggcccgacag tgtttggact ggttcagtat 53881 gagtcgaagg tgcagagaat ttataacggg ttaagaggct tctgcgatca agtttatgcg 53941 gtgagaatga tcggcgaaca gaacgctctt gattaaatcc gtatgttaag ttatattgat 54001 cttaaaatat tcggattttg ggggtgagtt catgaagttt cgtcgcagcg gcagattggt 54061 ggacttaaca aattatttgt taacccatcc gcacgagtta ataccgctaa cctttttctc 54121 tgagcggtat gaatctgcaa aatcatcgat cagtgaagat ttaacaatta ttaaacaaac 54181 ctttgaacag caggggattg gtactttgct tactgttccc ggagctgccg gaggcgttaa 54241 atatattccg aaaatgaagc aggctgaagc tgaagagttt gtgcagacac ttggacagtc 54301 gctggcaaat cctgagcgta tccttccggg cggttatgta tatttaacgg atatcttagg 54361 aaagccatct gtactctcca aggtagggaa gctgtttgct tccgtgtttg cagagcgcga 54421 aattgatgtt gtcatgaccg ttgccacgaa aggcatccct cttgcgtacg cagctgcaag 54481 ctatttgaat gtgcctgttg tgatcgttcg taaagacaat aaggtaacag agggctccac 54541 agtcagcatt aattacgttt caggctcctc aaaccgcatt caaacaatgt cacttgcgaa 54601 aagaagcatg aaaacgggtt caaacgtact cattattgat gactttatga aagcaggcgg 54661 caccattaat ggtatgatta acctgttgga tgagtttaac gcaaatgtgg cgggaatcgg 54721 cgtcttagtt gaagccgaag gagtagatga acgtcttgtt gacgaatata tgtcacttct 54781 tactctttca accatcaaca tgaaagagaa gtccattgaa attcagaatg gcaattttct 54841 gcgttttttt aaagacaatc ttttaaagaa tggagagaca gaatcatgac aaaagcagtc 54901 cacacaaaac atgccccagc ggcaatcggg ccttattcac aagggattat cgtcaacaat 54961 atgttttaca gctcaggcca aatccctttg actccttcag gcgaaatggt gaatggcgat 55021 attaaggagc agactcatca agtattcagc aatttaaagg cggttctgga agaagcgggt 55081 gcttcttttg aaacagttgt aaaagcaact gtatttatcg cggatatgga acagtttgcg 55141 gaagtaaacg aagtgtacgg acaatatttt gacactcaca aaccggcgag atcttgtgtt 55201 gaagtcgcga gactcccgaa ggatgcgtta gtcgagatcg aagttattgc actggtgaaa 55261 taataagaaa agtgattctg ggagagccgg gatcactttt ttatttacct tatgcccgaa 55321 atgaaagctt tatgacctaa ttgtgtaact atatcctatt ttttcaaaaa atattttaaa 55381 aacgagcagg atttcagaaa aaatcgtgga attgatacac taatgctttt atatagggaa 55441 aaggtggtga actactgtgg aagttactga cgtaagatta cgccgcgtga ataccgatgg 55501 tcgcatgaga gcgattgcat ccatcacgct ggatcacgaa tttgttgtac atgatattcg 55561 tgtgattgat ggaaacaatg gtcttttcgt tgcgatgccg agtaaacgca cccctgatgg 55621 agagttccgc gatattactc atcctattaa ttcaagcacg cgaggaaaga ttcaagatgc 55681 cgtgttaaat gagtatcatc gtctgggtga cactgaagca ttagaattcg aagaagctgg 55741 agcttcttaa aaaataacca aaaagcaagg actgctgaaa gggctgacat aagccttttg 55801 ccggcggtcc ttttttaatt ctgatttttc aaacttagtt gcactcaata gaaaattctt 55861 gcacttcatg aagtctcctt gaaatcagaa gatatttagg atatattttt ctatggataa 55921 aagggatatt ggaggccaat aaatggataa gcggtttgca gttgttttag cggctggaca 55981 aggaacgaga atgaaatcga agctttataa agtccttcat ccagtttgcg gtaagcctat 56041 ggtagagcac gtcgtggacg aagccttaaa attatcttta tcaaagcttg tcacgattgt 56101 cggacatggt gcggaagaag tgaaaaagca gcttggtgat aaaagcgagt acgcgcttca 56161 agcaaaacag cttggcactg ctcatgctgt aaaacaggca cagccatttc ttgctgacga 56221 aaaaggcgtc acaattgtca tttgcggaga tacgccgctt ttgacagcag agacgatgga 56281 acagatgctg aaagaacata cacaaagaga agcgaaagct acgattttaa ctgcggttgc 56341 agaagatcca actggatacg gccgcattat tcgcagcgaa aacggagcgg ttcaaaaaat 56401 agttgagcat aaggacgcct ctgaagaaga acgtcttgta actgagatca acaccggtac 56461 gtattgtttt gacaatgaag cgctatttcg ggctattgat caggtgtcta atgataatgc 56521 acaaggcgag tattatttgc cggatgtcat agagattctt aaaaatgaag gcgaaactgt 56581 tgccgcttac cagactggta atttccaaga aacgctcgga gttaatgata gagttgctct 56641 ttctcaggca gaacaattta tgaaagagcg cattaataaa cggcatatgc aaaatggcgt 56701 gacgttgatt gacccgatga atacgtatat ttctcctgac gctgttatcg gaagcgatac 56761 tgtgatttac cctggaactg tgattaaagg tgaggtgcaa atcggagaag atacgattat 56821 tggccctcat acggagatta tgaatagtgc cattggcagc cgtacggtta ttaaacaatc 56881 ggtagtcaat cacagtaaag tggggaatga tgtaaacata ggaccttttg ctcacatcag 56941 acctgattct gtcatcggga atgaagtgaa gatcgggaat tttgtagaaa ttaaaaagac 57001 tcaattcgga gaccgaagca aggcatctca tctaagctat gtcggcgatg ctgaggtagg 57061 cactgatgta aacctgggct gcggttcaat tactgtcaat tatgatggaa agaataagta 57121 tttgacaaaa attgaagatg gcgcgtttat cggctgcaat tccaacttgg ttgcccctgt 57181 cacagtcgga gaaggcgctt atgtggcggc aggttcaact gttacggaag atgtacctgg 57241 aaaagcactt gctattgcca gagcgagaca agtaaataaa gacgattatg tgaaaaatat 57301 tcataaaaaa taatcctaaa ttcggaggtt tatccatgtc taatcaatac ggagataaga 57361 atttaaagat tttttctttg aattcgaatc cagagcttgc aaaagaaatc gcagatatag 57421 ttggagttca attagggaaa tgttctgtca caagatttag tgacggggaa gtccaaatta 57481 atatcgaaga aagtattcgc ggatgtgatt gttacatcat ccagtctaca agtgaccccg 57541 ttaacgagca tattatggaa ctgctgatta tggtagatgc gttaaaacgc gcttctgcaa 57601 aaacgattaa cattgttatt ccttattacg gttatgcgcg tcaagacaga aaagcaagat 57661 cccgtgagcc aatcacagct aaacttttcg ctaacctgct tgaaacagcc ggtgcgactc 57721 gtgtgattgc acttgacctg catgcgccgc aaattcaagg attctttgat ataccgattg 57781 accacttaat gggtgttccg attttaggag aatattttga aggcaaaaat cttgaagata 57841 tcgtcattgt ttcaccagac catggcggtg tgacacgtgc ccgcaaactg gctgaccgac 57901 taaaagcgcc aattgcgatt atcgataaac gccgtccgcg tccaaacgtg gcggaagtca 57961 tgaatattgt aggtaacatc gaagggaaga ctgctatcct catcgatgac attattgata 58021 ctgcaggtac gattacactt gctgctaatg cgctcgttga aaacggagcg aaagaagtat 58081 atgcatgctg tacacaccct gtactatcag gccctgcggt tgaacggatt aataattcaa 58141 caattaaaga gcttgttgtg acaaacagca tcaagcttcc tgaagaaaag aaaattgaac 58201 gctttaagca gctttcagtc ggaccgcttc tggccgaagc gattattcgc gttcatgagc 58261 agcaatcagt cagctatctg ttcagctaaa ccatttttcg aggtttaaat ccttatcgtt 58321 atgggtattg tttgtaatag gacaactaaa acgacaagag gatggtgctg aatatggcaa 58381 ctttaacggc aaaagaaaga acggacttta ctcgttcgtc tcttcggaat atccgtactt 58441 caggacatgt tccaggtatc atatatggga aggatacggg taacaaacct gtgtcattag 58501 acagtgtgga gctcatcaaa acgctgaggg acgaaggcaa aaatgcagtc attacgcttg 58561 aggtcagcgg agaaaaacac tcagtcatgg taacagacct gcagacggac ccgctgaaaa 58621 atgaaatcac tcatgctgat tttcaagtag ttaatatgag tgaggacatt gaagtggaag 58681 ttccgattca tctgaccgga gaagccattg gagtgaaaaa cggaggcgta ctgcagcagc 58741 cgttatatgc acttactgta aaggccaagc caaaagccat tccgcaaacg attgaggctg 58801 atatttcaag cctcgatgta aatgaagtac tgacgattgc ggatttgcct gctggcggtg 58861 actactcctt taatcatgaa tcagatgagg ttgtggcttc aatccttcct ccgcagcagc 58921 aggaagcagc tgaggtcgat gaagaggaat ctgccgatgc tcagcctgaa ggtgaaaacg 58981 aacaataata gcttaaggcg taaccctccc gcggttacgt cttttgtgct agaatgagaa 59041 gaattatagc ccgtttatga agacgggagt tatgtgacta agggaggatt cgccatgctt 59101 gtgattgccg gtctcggaaa cccggggaag aactatgaaa atacacggca taatgtcgga 59161 tttatggtga tagatcagct tgcaaaggaa tggaatatag agctgaatca aaataaattt 59221 aacggattat acggaaccgg atttgtttcc ggcaaaaagg ttctacttgt taaaccgctt 59281 acatatatga atttatcagg agaatgtttg cggcctttaa tggactacta tgatgtcgat 59341 aacgaagatt tgacagtcat ttacgacgac cttgaccttc cgactggcaa gatccgttta 59401 agaacgaaag gaagcgccgg agggcacaat ggcatcaaat cactgatcca gcatcttgga 59461 acgtccgagt ttgaccgtat ccgcatcgga atcggccggc ctgtaaacgg catgaaggtc 59521 gttgattatg tgttaggctc ctttaccaag gaggaggcac ctgagatcga agaagcggtt 59581 gataaatctg tgaaggcttg tgaggcttct ttgagtaaac cgtttttaga agtcatgaac 59641 gaatttaacg caaaggtata aaatgtaaca acaaagtcca tactacacca aaatgacttt 59701 ttcatcagga ggacccttgt atggctttgc attattattg tcgtcattgc ggagtgaaag 59761 taggcagtct cgaatcttca atggtatcga cagactcact tggatttcag cacttaacaa 59821 atgaggaaag aaacgatatg atttcttata aagaaaatgg agatgtccat gttttgacga 59881 tatgtgaaga ctgccaagag gcgcttgacc gaaatccgca ttaccacgaa tatcacacat 59941 ttattcaata aaaagctttg gtgtagacac tagaccaaag cgtttttctg ttctcgcagg 60001 aaacagagag gaggggccat atggacaaca ttcaaacctt tataaaagaa agcgatgact 60061 ttaaatccat catcaacggt ttacacgagg gcctgaagga acagctgctc gcgggtctgt 60121 cgggttccgc gcgttctgtt tttacttctg ctctggctaa tgaaacgaat aagcctatct 60181 ttctcatcac ccataactta tatcaagccc agaaagtaac agatgatctg acttcacttc 60241 tagaggatcg gtctgtcctt ttgtaccccg tcaatgaact catttcatca gaaatcgcag 60301 ttgcaagccc tgaattgcgg gcgcagcgat tagatgtcat taatagacta acgaatggag 60361 aagcgccaat tgtcgttgct ccggtagctg caatcagaag aatgctgccg cctgttgagg 60421 tgtggaaaag cagccagatg ctcattcaag taggccatga tattgaacct gaccagcttg 60481 cctcacggct ggtagaggta gggtatgagc ggtctgatat ggtttctgcg cccggggaat 60541 tcagtattcg cgggggaatc attgacattt atccgctgac ttcagagaat ccggtgagaa 60601 ttgaactttt tgacaccgag gtggattcaa tccgcagctt taattcagat gatcagcggt 60661 caattgagac ccttacctcg atcaatatcg gtcccgcgaa ggaattaatt atcagaccgg 60721 aagaaaaagc gcgggcgatg gagaaaatcg atagtggtct tgccgcgagc ttgaaaaaat 60781 taaaggctga caaacaaaaa gaaatacttc atgcgaatat ttctcacgat aaagaacgct 60841 tgtctgaagg ccagacagat caggagctcg tgaagtatct ctcatatttc tatgaaaagc 60901 ctgctagttt actagattat acacctgata atacacttct gattttggat gaagtcagtc 60961 ggattcatga gatggaagaa cagcttcaaa aagaagaagc ggagtttata acaaatcttc 61021 ttgaggaagg gaagattttg catgacattc gtttgtcatt cagcttccaa aaaatagtgg 61081 ctgagcaaaa acggcctctg ctgtactact ctttattttt gcggcatgta caccatacga 61141 gcccgcaaaa tatcgtcaat gtgtcaggcc ggcaaatgca gagtttccat ggccaaatga 61201 acgtgcttgc gggcgaaatg gagcgtttta aaaaatcaaa tttcactgtt gtgttcttag 61261 gagcaaacaa ggaacgtacg cagaaattgt catctgtttt ggctgattat gatatcgagg 61321 ccgccatgac agacagcaaa aaagcgcttg ttcagggaca ggtctatatc atggaaggcg 61381 agctccaatc gggatttgag ctgccgttaa tgaagcttgc cgttatcacg gaagaagaac 61441 tgttcaaaaa ccgtgtaaag aagaagccgc gaaaacagaa gcttaccaat gcagagcgca 61501 tcaaaagcta ttctgagctt caaattggag attatgtcgt tcatattaat cacgggatcg 61561 gaaaatacct ggggattgaa actcttgaaa tcaacggcat tcataaagac tatttaaata 61621 tacattatca gggcagtgac aagctttacg tccctgtaga acaaattgat caggtccaaa 61681 aatatgttgg ctccgaagga aaagagccaa agctgtataa attaggcgga agtgaatgga 61741 agcgggtcaa gaaaaaagta gagacatccg ttcaggatat tgctgatgac ttaattaagc 61801 tgtatgccga aagagaagcg agcaagggct atgcgttttc tcctgaccat gagatgcagc 61861 gtgaattcga atcggctttc ccttatcaag agactgagga tcagctccgt tctattcacg 61921 aaatcaaaaa agacatggaa agagaacgtc cgatggaccg cttgctgtgc ggagatgtgg 61981 gctacggtaa aacagaggtt gccatacgtg ccgcgtttaa ggcgatcggt gacggaaagc 62041 aggtagctct gctcgttccg acaaccattt tggcacagca gcactatgaa accataaaag 62101 agcgcttcca ggactatccg attaatatcg gccttctcag caggttcaga acgagaaaag 62161 aagcaaacga aacaatcaaa gggctgaaaa atggaacggt tgatatcgtc atcgggacgc 62221 atcggctgct atcaaaggat gtcgtgtata aagacttagg gctcctcatc attgatgaag 62281 agcagcgttt cggtgtaacc cataaagaaa agatcaagca aataaaagcc aatgttgatg 62341 tattaacgtt aacagcaacg ccgattccgc gtacgctgca tatgtctatg cttggcgtaa 62401 gggacctttc agtcatcgag actccgccgg aaaatcgctt ccccgtacag acgtatgttg 62461 tggaatataa cggcgctctt gtcagagagg cgattgaacg tgagcttgca cgcggaggcc 62521 aggtctattt cttgtacaac cgggtagagg acattgagcg gaaagcggat gaaatttcaa 62581 tgctagtccc tgacgcgaag gtagcatatg cgcatgggaa aatgacagaa aatgaattag 62641 aaaccgttat gctaagcttc cttgaaggag aatcagacgt tctcgtcagc acaaccatta 62701 tcgaaactgg cgtggacatc ccaaacgtca atacgctgat cgtatttgac gccgacaaga 62761 tgggactttc tcagctttac cagctgcggg ggcgtgtcgg ccgttctaac cgtgtggcgt 62821 atgcgtactt cacgtatcgc cgggataaag tgctgacaga agtggctgaa aaaaggctgc 62881 aggctattaa agaattcaca gagttaggtt ccggttttaa aatcgcaatg cgtgacttaa 62941 cgattcgcgg agccgggaat cttcttggtg cccagcagca tggcttcatc gattcggtcg 63001 gatttgacct ctattcacaa atgctgaagg aggccattga ggagcgtaaa ggagacacag 63061 cgaagacaga gcagtttgaa acagaaattg atgtcgagct tgatgcgtat attccggaaa 63121 cttatattca agacggcaaa cagaaaattg atatgtataa acgcttcagg tctgtggcga 63181 caatcgaaga gaagaatgag cttcaagatg aaatgatcga ccgctttgga aactatccaa 63241 aagaagtcga atacttgttt actgttgcag aaatgaaagt ctatgcgaga caggaacgtg 63301 tcgagctgat taagcaggat aaagatgctg tcagattgac gatttctgaa gaagcaagtg 63361 ctgaaattga cgggcagaag ctgtttgagc ttggcaatca atatggcaga caaatcggac 63421 tgggaatgga agggaaaaaa ctcaaaatct ccatacagac gaaaggccgt agtgctgatg 63481 aatggctcga caccgtgctg ggcatgctga agggcttaaa agatgtgaaa aagcaaacca 63541 tttcatcaac gtaaattttg ttactctctg gtgtatatta catttgatgt gacggatact 63601 aatttcaagc gaggcggaag gtacataaag taactgcttt aggtctttcc cacatgtata 63661 taccatcaaa tgaaagagag gcaccagaga tgaaagcaac cggtatcgta cgtcgtattg 63721 atgacttagg tcgggtcgtg attcctaaag aaattcgaag aactctgaga atcagggaag 63781 gcgatccgct tgagattttt gtagatcgtg acggagaagt gattttgaaa aagtactctc 63841 cgatcagtga gcttggagac tttgcaaagg agtatgcaga cgcgctttac gacagcctcg 63901 gccattcagt gctgatttgt gatcgtgatg tatatattgc cgtgtccggc agctccaaaa 63961 aagattactt aaacaagtca atcagcgaaa tgctggaaag aacaatggat cagcgcagct 64021 ccgtgcttga gagtgatgcg aaatcagtac agcttgtgaa tggaattgat gaggacatga 64081 attcttatac tgtaggccca attgtggcga acggtgatcc gataggtgct gtggtgatct 64141 tttcaaaaga tcagacaatg ggcgaagtag agcataaagc cgttgaaaca gcagctggat 64201 ttttggctcg tcaaatggaa cagtaggtct tattcctttc ttcgaaaata ggtatgtaaa 64261 gaacagctct ccttgggacg ctgttctttt tcatgcgtgc cgaaaaagga atccaagggt 64321 tgggatgtgg tataataacc tcgtttttat ttgtgccgcg gtaatacgtg aaccgtattg 64381 cccctgacgt tgggaaggag cttttggatg gacgattcaa taggcgttaa acggcattgg 64441 atttggcagg gggcttttgt tttaattctg gcaggcgtca tcacaaaaat tttaagcgct 64501 gtttacagag tcccgtttca aaacattgtc ggcgatgttg gattttatat atatcagcag 64561 gtatacccct ttcttggtat tgcggtcatg ctgtccacat caggatttcc agtcattatt 64621 tcaaagctga tgaatgatta tagtgaaaaa aatcatcaca ccatattaaa aatatcagcg 64681 ttgtttttgt ctttaatcgg tattttatta tttctttgtt tatatctggg tgctgttcct 64741 attgcactct ttatgggaga ttcgcatcta gccgtgttaa ttcaagtggc cgcatacgcg 64801 tttctgcttt tcccatttgt cgcgttgcta agaggcggtt ttcaggggcg gcacgaaatg 64861 ctcccttcag ccttatcaca gatgacagag cagtttctgc gtgttgcggt gctcttgggt 64921 ttatcatttt ggctcgtgaa aaagggagcc tcgctttata ctgcgggagc ggcagccgct 64981 tcaggctctc ttgccggaag tttggttgca ttgataatac tggggttttt ttggttcaaa 65041 acgaaaagag acaaccaaac ggataggcaa aacgaaaatg tcatcacaac aaaagaattg 65101 acgaaaaaac tgcttttata ttcggtcaca atttgtgtaa gcagtttgct gcttttgttt 65161 atccagcttg ttgatgcttt gaatttatat gcattgcttt cgggtggtga ggcaagcgaa 65221 gaagcaaaat gcctaaaggg gatctatgat cggggacaac ccttgttgca gctcggttca 65281 gtttttgccg taagcattgc gacgtcactc gttccgtata tttctatggc tgtaaaaaac 65341 aaagagctga agatcatgaa agaaaaaatc acgtcatctt tgaaactatg ccttgtgctc 65401 ggtacaggcg catcggctgg gttgatttgc attctaaagc cggtaaatat catgctgttt 65461 caaaatggag aagggacagg tgcgttacaa gtatttagct gctccatttt gtttgcatcc 65521 ttggcggtaa cggcagcggc agtcttacag ggagcgggat acacagtttt tcctgcgata 65581 gcggtgggcg cgggtgttgc ggtgaaatgg gtgttaaaca cacttttggt tccgcgctat 65641 gggattgaag gcgcatcgct tgcgacagcg gcttcctttg cggctgtcgc cggccttaac 65701 ttgtatcagc ttcggcaaaa ggaatggctc gataagctta gaggcgtttt gattccgatt 65761 attggatctg ctcttttgat gtcagctgtt ttgcttgcgt atacgcgtct ctggactttc 65821 ttgtttcctg caacaggaag aggagcggct gtgattgaga gtctttctgc tgttgccatt 65881 ggtggcgcgg tgtttattta ttgtatgatg agattgggaa tatttacaga tgaagagctg 65941 aacagtgtgc cattcggcag caagttaagc aaattcatga gaaggagaga acaaaatggc 66001 gggtaaaatt acagtcgtcg gacttggtgc cggagacatg gaccaattga caattggtat 66061 acacaagctg ctgacgaagg cagatacgct gtatgtcaga accaaggatc atcctttaat 66121 tgaggagctt gaaaaagaaa cgaagaacat ccgtttcttt gatgatatat atgagaaaca 66181 tgatcagttc gaggcggtat atgaagaaat tgcagatatc ctctttgaag cggcgcggcg 66241 tgaggacgtg gtttacgctg tgccgggaca cccttttgtc gcagaaaaaa cagttcagct 66301 gctgacggag cggcaggaaa aggaaaacgt tcaagtgaaa gtcgcggggg gacaaagttt 66361 ccttgatgcc acattcaatg tcttgcaaat tgacccgatt gaaggttttc aatttgtgga 66421 tgccggcaca ttgtccgcgg atgagcttga gctcagacat catctgatca tatgtcaggt 66481 ttacgaccaa atgacggctt ctgaagtcaa gctgacattg atggagaagc tgcctgatga 66541 ttatgaggtc gtcattgtga ctgcagcagg cagccgtggc gaggagatca ggacagtgcc 66601 attatttgag ctggaccgca atgtcgcttt gaacaactta acaagtgtgt atattccgcc 66661 gattaaagaa gagaagctgc tttatcacga attctccacg ttccgaagca tcatcagaga 66721 gcttcgcgga cctaatggat gtccgtggga taaaaagcag acgcatcagt cattaaagca 66781 gtacatgatt gaagaatgtt atgagcttct cgaagctatt gacgaagaag acacagacca 66841 tatgatcgaa gagcttggcg acgttttgct tcaggtcttg cttcacgcgc aaattggtga 66901 agatgaaggt tatttcacaa ttgatgatgt cataaaagga atcagtgaaa aaatggtccg 66961 aagacatccc catgtgttta aagatgttaa ggttcaggat gaaaacgatg ttttagccaa 67021 ttgggaagat ataaaaaagg ccgaaaaaaa tacatctgaa tcatcattac tagacagcgt 67081 accgaaaacc cttccagctc tttcgaaagc agctaaattg cagaaaaaag cagcgaaggt 67141 cggttttgac tgggaagacg tcagcgatat ttgggaaaag gtaagtgagg aaatgaagga 67201 attttcttct gaggtttctg aagctcctca cgaacacaat cttaaagctg agtttggcga 67261 cattttgttc gcgctggtga atgtagcccg cttctacaaa atagagccag aggaagcgct 67321 gaccatgact aatgacaaat tccggagacg gttctcgtac attgaggaaa cagcgaagga 67381 agagggagtc gagttggctg atatgtccct tgaggacatg gacaaactgt ggaatgaagc 67441 aaaagaaact gagaggagat catagatatg agattagata aatttttgaa agtatcacgg 67501 ctgatcaaac ggcgtacact agcgaaggaa gtagctgacc aaggacgaat ctctattaac 67561 ggaaaccaag ctaaagctag ctctgacgta aaaccgggag atgaactaac ggtccgcttc 67621 ggccaaaagc ttgtaacggt tcaagttaat gaattgaaag acacgacgaa aaaagaagaa 67681 gctgcaaaca tgtacacgat tctaaaagaa gaaaaactcg gcgaataggc ttgttctaaa 67741 aaaacccccc acctcataca atgcagtaat aatgctaaaa gtatcgagga tatgggggct 67801 gaatagatga attcatatta tgatcaaaaa ggttcttcgt ctgttccgga acagcatgat 67861 gtgacaatga aaggccggaa gcatttagat atttctgggg ttaagcatgt ggagagtttt 67921 gataacgaag aattcctgct ggaaacggtg atgggaatgc tctccgtcag aggccaaaac 67981 ctgcagatga aaaatcttga tgtggaaaaa gggattgttt cgattaaagg cagggtattt 68041 gatttagtgt acttagacga acaacaaggg gataaagcta aagggttttt tagcaagttg 68101 tttaaatgac gctgacgaca caattctata caatgctagc gatgtccggt atgggtctct 68161 ggcttggtgc ttcgcttgat acataccggc tctttgtcat tcgtgccaaa acagccagat 68221 ggctattatt tattcatgat attcttttct ggattatgca agggctgctt ttcttttatg 68281 tcttgcttca tgtaaatgag ggagaattca ggatttacat ctttttagcg gttctgctgg 68341 gcgttgcgac gtatcagagc ctttgcaaac gaatctatat aaaaatactg aaattcgtca 68401 tttaccttgt tgtttctgtt tatcaattct tcaaaaaact cattcagcac gtgttatttc 68461 gtcctattgt gtggacatgc ggagcgatca tctggctggc ggcattttta ttcaagaaaa 68521 catacagcct gataggtttt ctcctgctgt gtctatataa aatagtcatg gttctgtgtt 68581 ttccgatccg ttttatcgcg aaacaatgtt tgaaacttct tcctgtgaaa atgcgtctaa 68641 cttttagacg ttattttgaa aaaggtgcag gatttctcaa aaagaagaag aaactattga 68701 taaccataag aacgaccatc acacggtttt tgaagagatg aaaggaggac cgtctggttt 68761 gaatttttcc agggaacgaa cgataactga aatacaaaac gactataaag aacaagtaga 68821 acggcaaaat cagctgaaga aacgaagacg caaagggctg tacagacggt taactgtatt 68881 cggcgcccta gtattcctga cggcaattgt gctggcaagc tctgtatggt cccaaacatc 68941 ttcccttagt gcaaaagaag aaaagaaaga acagcttgaa aaagaactga aaagtttaaa 69001 gacaaaacaa acggatttaa aagaagaaat atccaaattg aaggatgagg attacgtcac 69061 agagcttgcc agaagggact tattcatgtc tggagacgga gaaattatct tcaatgtgga 69121 gaagaagagc aagtagcctt gttgacactt aaatttttat ttaggtataa ttaagcaaac 69181 gatcttttta taagcctaag gaggagcact ttttttatgt cgattgaagt tggcagcaag 69241 ttgcaaggga aaattacagg tattacaaat tttggagcat ttgttgaatt gcctggaggc 69301 tcaaccggtc tcgttcacat tagtgaggta gctgataatt atgtcaaaga cattaacgac 69361 cacttaaaag tcggcgacca agttgaagtg aaagtcatca acgttgaaaa agacgggaaa 69421 attggtttat ctattaaaaa agctaaagac cgtccgcaag ccagacctag aaatgatttc 69481 cgtccgaaag aatcttttga acagaaaatg aataagtttt taaaagacag cgaagatcgc 69541 ttgtcatctt taaaacgcaa tacggaatca aaacgtggag ggcgcggagc aagaagagga 69601 taacttgctg ctttctataa aataaatgaa gcatccgttc atcccgacgg atgctttttt 69661 attatcctca ttctctttaa gagtcagaaa attacaacat taaagtttct gttgacgaaa 69721 gagacaaacc tttgtattat ataacttgtg cttagaagca caaaacaata tggcggtgta 69781 gctcagctgg ctagagcgta cggttcatac ccgtgaggtc gggggttcga tcccctccgc 69841 cgctaccata tttgtttggc ccgttggtca agcggttaag acaccgccct ttcacggcgg 69901 taacacgggt tcgaatcccg tacgggtcat cctaacaaat cggtttctct tgcagaagcc 69961 gatttttttc atttttagac aacattccgg aaattctttt cataaacgaa tatcaaggca 70021 gaaaccgtcg aagatttctt tggtattgtt accttctttt gacaaaatcc tatctgtgct 70081 ttcgctataa tgacaggcaa cgaatataac aggtgggaga tgagaggaat ggaaaaagca 70141 gaaagaagag tgaacgggcc aatggcggga caagctttgg aaaaactcca atcgtttttt 70201 aacaggggca cgaagctggt gactcatcat ttgcattcac tgtttttcta taaaggattc 70261 atttatgttg tcatcggatt tttgcttgga cgggctttca tattatccga ggtgcttcct 70321 ttcgcacttc ctttctttgg agcgatgctt cttatcagaa gagacaaagc gttttatgcg 70381 gttttggctg tgcttgcagg tgcgctgacc atatctccaa agcactcatt gctcatactg 70441 gcggcattgc tggcattctt cgtattttct aaagtggctg ccttcattac cgacgatcgt 70501 gttaaagcgc tcccgattgt cgtgttcttc tccatggctg cagcaagagc cgggtttgtt 70561 tatgcccaaa atggcgtatt tacaacctat gattatgtaa tggctatcgt tgaggctgga 70621 ctatcgttta tcttaacact gattttcctt cagagccttc cgatttttac tgtgaaaaaa 70681 gtgaaacaat cattaaaaat agaggaaatc atttgcttta tgattcttat tgcctctgtt 70741 ttaacggggc tggctggctt gtcctaccaa gggatgcagg cagaacatat attggctcgt 70801 tatgttgtgt tgagtttttc ctttattggc ggagcaagca tcggctgtac ggttggggtt 70861 gtgaccggcc tgattcttgg cttggcgaat atcggaaacc tatatcaaat gagtctgctt 70921 gctttttccg gtttattggg cggtttgctg aaggaaggga aaaaagcggg tgcagcaatt 70981 ggtttgatcg ttggatcact tcttatatct ttatatggtg aaggctctgc cggtctgatg 71041 acaacgctct atgagtcatt aatcgcagtc tgcctgtttt tgctcacacc tcaatctatt 71101 acgaggaaag tggcgagata tattccggga actgtcgagc atcttcaaga gcaacagcaa 71161 tacgctagaa aaatccgtga tgtcactgct cagaaggtag accaattctc caatgtattt 71221 cacgcgctgt ctgaaagctt tgcaaccttt tatcaagcat cagacgaaca gacagatgac 71281 agcgaagttg atctgttctt aagcaaaatc acggagcatt cctgccagac gtgctacaag 71341 aaaaacaggt gctgggtaca gaactttgat aaaacatatg acttaatgaa acaagttatg 71401 cttgaaacag aggaaaaaga atatgcatca aaccgaaggc tgaaaaaaga gtttcaacag 71461 tattgttcta aatccaagca ggttgaagag ctgattgagg atgagctcgc acatcatcat 71521 gcccatttga cactcaagaa aaaagtccaa gacagcaggc gccttgttgc tgaacagctt 71581 ttaggcgttt ctgaggttat ggccgacttt tctcgggaaa taaaaagaga gcgagaacaa 71641 cactttctgc aggaagagca aatcatagaa gcgcttcagc atttcggaat tgagattcag 71701 catgtcgaga tctatagtct tgaacaagga aatatcgata ttgaaatgac cattccgttc 71761 agcggacatg gagaaagtga aaaaatcatt gctcctatgc tttctgacat tctggaggaa 71821 caaattcttg tgaaagccga acagcactct ccgcatccga atggatacag ccatgtcgcc 71881 tttggatcaa caaaatcata cagggtgtcc acgggagctg ctcacgctgc gaagggcggc 71941 ggccttgtct ccggtgacag ctacagcatg atggagcttg gagccagaaa atatgctgca 72001 gcaatcagtg acggaatggg caatggcgca agagcgcact ttgaaagcaa tgaaacgatc 72061 aagcttcttg aaaaaatcct tgaatcgggc attgatgaaa aaatagcaat taaaacgatc 72121 aacagcatac tgtctctaag gacaactgac gaaatatatt ccacgcttga cctatctatt 72181 atcgatcttc aagatgccag ctgtaaattt ttgaaggttg gatcgacgcc cagctttatc 72241 aaacggggtg accaggtcat gaaagttcaa gcgagcaatc tgccaatcgg tattattaat 72301 gaattcgatg tggaggttgt gagtgaacag ctgaaagcgg gtgacctctt aattatgatg 72361 agtgatggca tttttgaggg gcctaagcat gtggaaaatc acgacttatg gatgaagcgt 72421 aaaatgaaag ggttgaaaac aaatgacccg caggagattg ccgatttgct tatggaagaa 72481 gtcatccgca caagatccgg ccaaattgag gacgatatga ctgttgttgt cgtccggatt 72541 gatcacaata caccgaagtg ggcatccatt cctgttccgg caatctttca aaacaaacaa 72601 gaaatttcat aacgcttccg tataaatcaa atttcttctg gcgaagatgg gaatatatga 72661 atctgagaat cctcgtattc tccaggagga atgaatgtga acaacggaca tttaaatcaa 72721 attttgctga taacggatgg ctgctcaaac catggggaag acccgcttgc aatggctgct 72781 tttgctaaag agcaggggat tacggtaaat gtcattggta taatggaaga aaatcaaatt 72841 gaccctgagg caatgaagga agtcgaaggg attgcacttg ccggaggagg cgtgcaccaa 72901 gtcgtttatg catctcagct ttcacaaact gttcaaatgg taacaaagaa agcgatgacg 72961 caaaccttac aaggtgtagt caatcaagaa ctgaaacaga ttctcggaaa gaatgtggaa 73021 atggaagagc tttctccgga aaaacgcggc gaagtcatgg aagtggtaga cgagcttgga 73081 gaaacggtgc atcttcaggt tttggttctt gttgatacaa gtgcaagtat ggcgccaaag 73141 cttccaacag taaaagaggc gctgattgat ttgtctgtaa gcctcaattc ccgaattggg 73201 aataacgaat ttgcgatgtg tatatttccc gggaaaaaac aagaggtcga gcttgtgctg 73261 aactggacac cgaagctgca atctctttcc acactctttg caaagctttc gacaggcggc 73321 atcacgccga caggtccggc gattcgtgaa gcgacactgc agtttgaaaa aatacgctca 73381 agaaggggca tgctggcaga tgatgaacga cgctttgacg agtttggcat gtagcctcaa 73441 gccgggtacg acaatcaaag gcaagtggaa tggaaacact tatacattgc gtaaacagct 73501 tggtaaaggg gccaatggaa ttgtgtattt ggcagaaaca tcagatggac atgttgcctt 73561 aaaggtgagt gatgacagcc tgtctattac ttctgaagtg aatgtcttga aatctttctc 73621 aaaggcccag tccgttacga tggggccttc tttttttgat acggatgatg cctatattcc 73681 cagtgccaat acgaaagttt cattttatgc aatggaatac ataaaagggc cgctgctttt 73741 gaagtatgtc agtgataaag gagcagagtg gataccggta ttaatgattc agctgttatc 73801 cagcttatcg gtgcttcacc agcaaggatg gatattcggc gatcttaaac ctgataatct 73861 gatcgtaact ggtccgcccg caaggatccg ctgcattgat gtgggcggca cgacaaagga 73921 aggccgggcg ataaaagagt atacggagtt ttatgacaga ggctattggg ggtatggaac 73981 aagaaaggca gagccatcct atgatctgtt cgcagttgcc atgattatga tcaacagtgt 74041 gcataaaaaa gaatttaaga aaacgaacca gcccaaagaa cagcttaggt ctctcatcga 74101 aggaaacccg ctgcttcaaa agtataaaaa agcgcttttt tcagccttga acggagatta 74161 tcaatccgca gatgaaatga aaaaggatat gctagacgcg gggcaaaaag cagcacaaag 74221 aaaacagcct ataaaagcat caccgcagcc tgccacacga caaagacagc aaaaaccgcg 74281 ccaaggaaaa ataacgaaga cgcgatatac cccaaaacag aaaccggcta agtcgggggg 74341 gttatttgaa acaacgctta tcgtgatcag tgttttagcg ctttatttcg cctatattat 74401 ctttttctta atctgaatgg tgcaaactgc agagcctatg cttcttcttt gcttggaggg 74461 gttgaaagtg ttaggatatg aatatcttta aaatacctgc tcattgtgag gaggacattg 74521 tgaaaagtgt caaagatttt ttaaacaaac acaatcttac gttaaaaggg gcgacaatca 74581 ttgtaggcgt ttccggcggt ccggactcaa tggctcttct tcacgcgttg catacgttat 74641 gcggccgttc agcgaatgtt attgcagctc acgttgacca tcggttcaga ggtgcggaat 74701 ccgaggagga catgcgtttt gtccaagctt attgtaaagc tgaacagctc gtgtgcgaaa 74761 cggctcaaat caatgtaacc gcatatgcac aggaaaaagg actcaataag caggctgcag 74821 cacgcgattg ccgctaccag ttttttgagg aaatcatgtc gaagcaccaa gcggactatc 74881 tggctcttgc gcatcatggt gatgaccagg ttgaaacaat gcttatgaaa ctggctaagg 74941 gtacgcttgg aacgggactt gcgggaatgc agccggttag acgttttggg acagggcgga 75001 tcatcaggcc gttcttaacc attacaaagg aagagatcct tcactattgc catgaaaacg 75061 gcttgagcta ccggacggat gaaagcaacg ccaaagatga ctacacaaga aacagattca 75121 gaaaaacagt gctcccgttt ttgaagcagg aatctccgga tgtgcataaa aggtttcaga 75181 aagtgagtga agcactgacg gaagatgagc aattcttaca gtcattaacg aaagatgaaa 75241 tgaataaagt aatcacaagc cagtctaata catcagttga aatcaattcc tctcaattgc 75301 ttgccctccc gatgccttta caaagaagag gagttcaact aatattaaac tatctttatg 75361 aaaacgttcc atcatccttt tcagcccatc acattcagca gtttctcgat tgggcggaaa 75421 atggcggtcc ttcaggagta ctggactttc cgaaagggct gaaggtggtc aaatcatatc 75481 agacatgttt gtttacattt gaacaatggc agtgcaaaaa tgttcccttt gaataccaaa 75541 ttagcggagc tgctgatgaa acggcagtgc tccctaatgg atatctgata gaggcaaggc 75601 attatgcgga ctcgcctgaa gaacatggga atgctgtttt tatcacaagt gaaaaaaagg 75661 tgcgatttcc cttaacaatc cggacgagaa aagctggaga ccggatcaaa ctaaaaggga 75721 tgaacggctc aaaaaaggta aaggatatat ttattgataa gaaattgcct ctccaagaaa 75781 gagacaactg gccgattgtg acggacgcaa gcggtgaaat tatctggata cctggcttga 75841 aaaaatcaat ttttgaagat cttgtgattc caaacagcga ccgcattgta ttacaatata 75901 gacagcatga aaagtgtagg gggcaagcaa aatcatgatg aaacatgata tcgagaaagt 75961 actgatctca gaggaagaga tacaaaagaa agtaaaagag ttaggtgcag aattaacgag 76021 cgagtatcaa gatacatttc cgttggcaat cggtgtgtta aaaggagcac ttccttttat 76081 ggcggatctt atcaagcata ttgatacata tttggaaatg gatttcatgg atgtatcaag 76141 ctacggaaat tctacggttt cttctggaga agtaaaaatc attaaagatt tggatacatc 76201 tgtagagggc cgggacatct taattattga agatatcatc gacagtgggt taaccttaag 76261 ttatctcgta gagctcttcc gataccgtaa agcaaaatca attaagattg ttaccctttt 76321 ggataaaccg agcggaagaa aagcggacat caaagcagac tttgtcggtt ttgaagttcc 76381 tgacgcgttt gtagtgggtt acggacttga ttatgctgag cgctatcgca atctgcctta 76441 tatcggagtg ttaaaaccgg cagtttatga aagctgatcg gcagcctgct tccgagatgg 76501 ttattgtttg tattggaatg attttctatg gtactattga acatagttgt gcttactgtg 76561 ggaggaggta aggaatgaat cgggtcttcc gtaataccat tttttattta cttattttat 76621 tagtagtaat cggggttgtg agctacttcc agacctcaaa tccgaaaaca gaaaatatgt 76681 cgtacagtac gttcatcaaa aacctggatg acgggaaagt tgatagcgta tcggttcagc 76741 ctgtcagagg tgtttatgag gtaaaagggc agctgaaaaa ctacgacaaa gatcaatact 76801 ttttgactca tgttcctgaa ggaaagggag cagaccagat atttaacgct ttgaaaaaga 76861 cagacgtaaa ggttgagccc gcgcaagaaa caagcggatg ggtgacgttc ctgacgacca 76921 tcatcccatt tgtcattatc tttattctgt ttttcttcct gctcaatcag gctcaaggcg 76981 gcggcagccg tgtcatgaac tttggcaaga gtaaagcgaa gctgtataca gaggaaaaga 77041 aacgcgtcaa atttaaagac gttgcagggg ctgacgaaga aaagcaagaa cttgttgaag 77101 ttgttgagtt tctgaaagat ccccgcaagt ttgccgagct cggcgccaga ataccgaaag 77161 gcgtgctttt agtcggacct ccgggtaccg gtaaaacatt gcttgccaag gcttgtgcag 77221 gagaagccgg cgtacctttc ttcagcatca gcggatctga tttcgttgaa atgtttgtag 77281 gggtcggtgc ttcccgtgtg cgtgacttgt ttgaaaatgc gaaaaagaat gcgccttgtt 77341 tgatcttcat tgatgaaatt gacgcagtcg gacgccagcg tggcgctggt ctcggcggtg 77401 gacacgatga acgtgaacag acgctaaacc aattgcttgt tgaaatggac ggattcagcg 77461 ctaatgaagg aattatcatc attgctgcga cgaaccgtgc ggacatcttg gacccagcct 77521 tacttcgtcc gggacgtttt gaccgtcaaa tcacagtgga ccgcccagat gtcattggcc 77581 gtgaagctgt attgaaagtc catgcgagaa acaaaccgct ggatgaaacg gttaacctaa 77641 aatcaattgc catgagaaca ccaggcttct caggcgctga cttagaaaac ctcttgaatg 77701 aagctgcgct tgtagcggct cgtcaaaaca agaaaaaaat cgatgcgcgt gatattgacg 77761 aagcgacgga ccgtgtaatt gccggacccg ctaagaagag ccgcgttatc tccaagaaag 77821 aacgcaatat cgtggcttat cacgaaggcg gacacaccgt tatcggtctc gttttagatg 77881 aggcagatat ggttcataaa gtaacgattg ttcctcgggg ccaggctggc ggttatgctg 77941 ttatgctgcc aagagaagac cgttatttcc aaacaaagcc ggagctgctt gataaaattg 78001 tcggcctctt gggcggacgt gttgctgaag agattatctt cggtgaagtc agcacagggg 78061 cgcacaatga cttccagcgt gcgacgaata ttgcaagacg aatggttaca gaattcggta 78121 tgtcagaaaa actgggaccg ttgcaatttg gacagtctca gggcggtcag gtattcttag 78181 gccgtgattt caacaacgaa cagaactaca gtgatcaaat cgcttacgaa attgatcagg 78241 aaattcagcg catcatcaaa gaatgttatg agcgtgcgaa acaaatcctg actgaaaatc 78301 gtgacaagct tgaattgatt gcccaaacgc ttctgaaagt tgaaacgctt gacgctgaac 78361 aaatcaaaca ccttatcgat catggaacat tacctgagcg taatttctca gatgatgaaa 78421 agaacgatga tgtgaaagta aacattctga caaaaacaga agaaaagaaa gacgatacga 78481 aagagtaatt cgctttcttt ctaaaaaaac tgccggctga cgctggcagt ttttttatgt 78541 aaatgattgg ctcagctgcg gcttttacaa tcatccaatt ctggtatcga tttgtttaca 78601 aatgagccgc tgatcgtgta tggtattgta gaatgtttgt aaaaagtaaa gtagagaaac 78661 tattcaaaag tggtgataga ggttgttact ggttatcgat gtggggaaca ccaatactgt 78721 acttggtgta tatcatgatg gaaaattaga atatcactgg cgtatagaaa caagcaggca 78781 taaaacagaa gatgagtttg ggatgatttt gcgctcctta tttgatcact ccgggcttat 78841 gtttgaacag atagatggca ttattatttc gtcagtagtg ccgccaatca tgtttgcgtt 78901 agaaagaatg tgcacaaaat actttcatat cgagcctcaa attgttggtc caggtatgaa 78961 aaccggttta aatataaaat atgacaatcc gaaagaagta ggggcagaca gaatcgtaaa 79021 tgctgtcgct gcgatacact tgtacggcaa tccattaatt gttgtcgatt tcggaaccgc 79081 cacaacgtac tgctatattg atgaaaacaa acaatacatg ggcggggcga ttgcccctgg 79141 gattacaatt tcgacagagg cgctttactc gcgtgcagca aagcttcctc gtatcgaaat 79201 cacccggccc gacaatatta tcggaaaaaa cactgttagc gcgatgcaat ctggaatttt 79261 atttggctat gtcggccaag tggaaggaat cgttaagcga atgaaatggc aggcaaaaca 79321 ggaaccaaag gtcattgcga caggaggcct ggcgccgctc attgcgaacg aatcagattg 79381 tatagacatc gttgatccat tcttaaccct aaaagggctg gaattgattt atgaaagaaa 79441 ccgcgtagga agtgtatagg aggtttagta atggattatt tagtaaaagc acttgcgtat 79501 gacggaaaag ttcgggctta tgcagcgaga acgactgata tggtaaatga ggggcagaga 79561 cgccatggta cgtggccgac agcatccgct gcactaggcc gtacaatgac agcttcactt 79621 atgctcggcg ctatgctgaa gggcgatgat aagctgaccg tgaaaatcga gggcggaggt 79681 ccgatcggag ctattgtagc tgatgccaat gccaaaggag aagtcagagc ctatgtctct 79741 aacccgcaag ttcattttga tttaaatgaa caaggtaagc ttgatgtcag acgtgcggtt 79801 ggaacaaacg gaacgttaag tgtcgtaaaa gatttaggtt tgcgcgagtt cttcacagga 79861 caagtagaaa tcgtttcagg agaattagga gatgatttta cttactatct tgtgtcatct 79921 gagcaggttc cttcatcagt gggcgtaggt gtgctcgtaa atcctgacaa taccattctt 79981 gcggcagggg gctttattat tcagctgatg ccgggaacag atgatgaaac aatcacaaaa 80041 attgaacagc gtctatctca agtagagccg atttctaagc tcatccaaaa agggctgaca 80101 ccagaagaaa ttttagaaga agtcctaggc gagaaacctg agattttgga aacgatgcct 80161 gtcagattcc attgcccttg ttcaaaagaa cggttcgaaa cagccatttt aggactaggc 80221 aaaaaagaaa ttcaagatat gatagaagaa gatggacaag ccgaagcagt atgccatttt 80281 tgtaatgaaa agtacttatt tacaaaagaa gagctggaag ggcttcgtga ccaaactacc 80341 cgctaagctc tttagcgggt ttttaatttg agaaaagggg ctgaaagcag gtttgaaatc 80401 aagaacaatc tggaccatta ttttaggggc gctgttggtt tgctgtattg ctgttgcata 80461 tacgctgacg aaatcccaag ccggcgcatc gtcatccggt gagtctattg cgactatcgg 80521 aggcaagagt gtgacaagag aagaatggct gaaagaaatg gaagatcagt atggtaagtc 80581 aacgcttgaa gatatgatca atgtccgagt tgttgagcag ctggctaaaa agaacaaact 80641 taaaatatcc aaaagcgaag ttgatcgtga gtttttgctg attaaagcgg tcaataattc 80701 cttttacgaa gatgaacata cgacggagaa agagtggaaa gaccaaattc gttataatat 80761 cctccttgag gatttgttaa caagggatat cgatatctca aacaaagaat tggaatcatt 80821 ctataataaa aataaggaac tatatcagtt tgatgattcg tatcgaattc ggcacattgt 80881 tgtaaaagat gaagaagaag caagagaagt cctgaaagaa ctgaaaggcg gatcaagctt 80941 tgaagctgtc gctgccgaaa gatctacaga cagatataca tcaccatacg gcggagattt 81001 aggttttgtc acagaggcat cagacaacat tccatcagca tacattgaag aggcgaaaac 81061 actcaaagag gatgaatggt ctcaggaacc aataaaggtc agcaacggat atgccattat 81121 ccagctgaaa gaaaaactaa aggcaagaac gttctcattt gatgaagtaa aggaccagat 81181 cagacggcaa atcgcaatgg atcagctagg cgataaagcg acagttaaga cactttggaa 81241 agaagccgat gtatcttggt tttatgggga aaaaagtact aagtgattga caaaaaattt 81301 tgaaattgat agattatata cataatacca atacaaatag tcggaaattg aggtgtcgag 81361 aatggtacgt gtagcaaact ccattactga attaattggg aatacgccaa tcgttaaatt 81421 aaatcgcctt gcagatgaaa acagtgcgga tgtatatcta aaacttgaat acatgaaccc 81481 tggaagcagt gtaaaagacc gtatcggttt agctatgatt gaagcggctg aaaaagaagg 81541 aaaattaaaa gccggtaata caatcattga accgacaagc ggaaatactg gaatcgggct 81601 tgcaatggtt gctgctgcta aaggattaaa agccattttg gttatgcctg atacaatgag 81661 catggagcgc cgcaaccttc ttcgcgcata tggtgctgag cttgtgctga ctcctggtgc 81721 ggaaggcatg aaaggtgcta ttaagaaagc tgaagagctt gctgaaaagc acggatactt 81781 tgtgccgcag cagtttaaca acccttctaa ccccgaaatt caccgccaaa caacgggtaa 81841 agaaatcgtt gagcaattcg gtgatgatca gcttgacgca tttgtagccg gaatcggaac 81901 gggcggaacg attacgggag cgggcgaagt gctgaaggaa gcataccctt ccatcaagat 81961 ttatgctgtt gaaccgtcag attccccagt gctttcagga ggaaaaccag gcccccacaa 82021 aattcaggga atcggagcag gattcgtgcc ggacatctta aacactgaag tatatgatga 82081 aatcttccct gtgaagaatg aagaagcatt cgaatatgcc cgcagagctg cacgtgaaga 82141 aggaattctc ggaggcatct catcaggtgc ggcaatttat gctgctcttc aagtagcaaa 82201 aaaactcgga aaaggcaaaa aagtattggc catcattcca agtaacggcg aacgttatct 82261 aagcacgccg ctgtaccaat tcgattaaaa aaagccaaaa ctcccggttc gccgggagtt 82321 tttttatatt tcgtgcatca aatatgccat gtctgcgacg aatgttattc ttggaagaga 82381 aattcacttt tttcactaac aacattgctt tacaattaaa aacaagtaaa aaagaaaata 82441 gaggaatgat acaaatggca caacgcagac cggcaggcaa aaaaatacct tttcaaaaag 82501 actcattctt acaacaattt gagaaacttg cgcaatcccg gaaacatcat gtacttctcg 82561 aaagtgcaag aggcggcaga tatagtatag ccggtcttga tccaattgcg actgtgaaag 82621 gaaaagacgg aataactaca attaagcatg gtgatgagat gctgtttaaa gaaggtgatc 82681 cattacgggc cttccacagc tggtttaaaa cactggaaac agaaacgaat catgagttcc 82741 ctgactttca aggcggggca atcgggtttc tcagctatga ttacgcacgg tacattgaaa 82801 attttaaaat gctctcatta gatgatttag aaacaccaga tatttatttt cttgtttttg 82861 atgatatagc agtttatgac catcaagaag agtctctatg gctgattact catgttaatg 82921 gttctgatca ggaaacagcg gatgtgaagc tatctgagtt agagcagatg tggttgactg 82981 agcttcccgc tgtcacttcg cgagagatga agcctgaaac agctggttct ttcgcggcgc 83041 catttaccga ggatgggttc tcacaagctg tagagaaaat caaacaatac attgccagcg 83101 gagatgtgtt tcaagtcaat ctatcaataa ggcagtcaca gtcactgtct gtccacccat 83161 atcaaattta caaaaccttg agagaagtaa atccttctcc ttatatggcg tatttagaaa 83221 cacctgattt ccaaatcatt tgcggatcgc ctgaactgct tgtcagcaaa aagggcaagc 83281 tattagagac gagaccgatt gcgggcaccc gttccagagg gaaaacaaat gaagaagacg 83341 aggcgcttgc aaacgaattg atacacaatg aaaaagaacg cgcggaacat gtcatgctgg 83401 ttgatcttga gcgaaatgat ctgggaagag tatcacgtta cgggtctgtg cgcgtaaatg 83461 aattcatggc aattgaaaaa tactcgcatg tgatgcacat tgtgtctaat gtccaaggtg 83521 aactgcagga tgggtatgat gctgtagata ttattcatgc tgtgtttccc ggaggaacca 83581 ttactggtgc accgaaagta agaacgatgg aaattataga agaacttgag ccgacacgcc 83641 gagggcttta tactggatct ataggatggt ttggatataa tcacgatctg cagtttaata 83701 tcgtcattcg aaccatttat gcaaccggag ggcaggcatt tatgcagtcc ggtgcaggag 83761 ttgtgattga ttctgttccg aagcacgaat acaaggaatc attcaaaaaa gcttttgcga 83821 tgcaaagagc attagagctg agcgaagaag agacaaaaat tagatgaggt gagcggagaa 83881 atgattttaa tgattgataa ctacgattca ttcacgtaca acttggtaca gtatttgggc 83941 gagcttgggg aagagctggt tgtgaaacgc aatgacagca tcacaatcga tgaaattgaa 84001 gaactgtctc cggactttct gatgatatct cccggaccgt gcagccctga tgaggcggga 84061 atcagcctcg aagcaattaa acatttcgca gggaaaattc ctattttcgg tgtatgtctc 84121 ggacatcagt ccatcgcaca agtgttcggt ggtgatgttg ttagggcaga acggcttatg 84181 cacgggaaaa cctcggatat cgagcatgac ggcaaaacca tttttgaagg gttgaaaaat 84241 ccccttgttg cgacgcgata ccactcgctg atcgtaaaac ctgagacgct gccaagctgt 84301 tttacagtaa cagcacaaac gaaagaagga gaaatcatgg ctattcgcca caatgacctc 84361 ccgatagagg gtgtgcaatt tcacccagag tctattatga cctcctttgg gaaagaaatg 84421 ctcagaaatt ttattgagac atatcgcaag gaagttattg cgtgatgata tatgtgaacg 84481 gccggtatat ggaggagaaa gatgcagttc tttctccttt tgaccatggg tttttatatg 84541 ggatcggtgt tttcgaaacc ttcaggctct acgaaggctg cccgtttttg cttgattggc 84601 atatagagag gcttgaacgc gcgcttaagg atctgcaaat cgaatatact gtttcaaagc 84661 atgagatcct tgagatgctg gacaagctgc ttaagctaaa tgatatcaag gatggcaatg 84721 cccgcgtcag actgaacata tcagcgggaa tcagcgataa aggctttgtc gcccagacgt 84781 acgataagcc caccgtttta tgctttgtga atcagctgaa accagaaagt cttcctttgc 84841 aaaaagaagg aaaggtttta tcgatacgga gaaacactcc agagggatcg ttccggttaa 84901 aatctcatca ttatctaaat aatatgtatg cgaaacggga aattggaaat gatccgcgtg 84961 tcgagggaat tttcttaacg gaggatggag ctgttgcaga gggtatcata tctaatgtct 85021 tctggagaaa aggtcgctgt atctatacgc catcgcttga taccggtatt ctggacggcg 85081 tcacgagacg ttttatcata gaaaatgcaa aggatatcgg cctggagctc aaaacgggcc 85141 gatatgagct agaagctctc ttgacagctg acgaagcgtg gatgacgaac tcggttcttg 85201 aaatcatccc gtttactaaa atagaagaag taaactatgg aagccaaagc ggagaagcaa 85261 cctccgctct tcaattgtta tacaaaaaag aaataaagaa catgattcat gaaaagggag 85321 gaagagcatg gcgcagcaca caatagatca aacacaagta atccacacta agcccagcgc 85381 tttatcatat aaagagaaga cgctggtgat gggaatttta aacgtaacgc ctgactcttt 85441 ctcggacggc ggaaaatatg acagcttgga caaggcgctg ctgcacgcga aagagatgat 85501 cgatgatggt gcccatatca ttgatattgg aggggaatcg acaaggcctg gcgctgagtg 85561 cgtatctgag gatgaggaga tgtccagagt cattccggtg attgagcgga ttacgaaaga 85621 gcttggtgtt cctatttctg tagacacgta caaggcttct gtcgcagatg aagcagtgaa 85681 agccggtgca tccattatca atgatatttg gggagccaaa catgatccga agatggcttc 85741 cgttgcagct gaacataatg ttccaattgt actcatgcat aaccgccctg aaagaaacta 85801 caatgactta ttgccggata tgctgtcgga cttaatggag agtgtaaaaa ttgctgttga 85861 ggccggagta gacgagaaga acattattct tgatcctggt atcggtttcg cgaaaaccta 85921 tcacgataac ttggcagtga tgaacaaact agagattttc agcggattgg gatatccggt 85981 tcttctggca acctcccgaa aaagattcat cggacgtgtt ctggatcttc cgcctgagga 86041 gcgggctgag ggcacaggcg cgactgtgtg tctcggcatt caaaaaggct gtgacattgt 86101 cagggtccat gatgtaaagc aaattgccag aatggcgaaa atgatggacg cgatgctgaa 86161 taagggaggg gtgcaccatg gataaagttt atgtagaagg tatggagttt tacggatatc 86221 acggtgtgtt cacagaagaa aacaaacttg gccagcggtt taaagtcgat ttaaccgctg 86281 agctggattt aagcaaagct ggacagacag acgaccttga gcaaacgatc aactatgctg 86341 agctctatca cgtatgtaaa gatatcgtgg aaggggagcc tgtgaaattg gtggaaacgc 86401 tggcggaacg tattgctggc actgttctcg gaaaatttca gcctgttcag caatgtacgg 86461 tgaaagtgat taagccagac ccgccaattc ccggacacta taaatcagta gcaattgaaa 86521 ttacgagaaa aaagtcatga acaacatagc ttatattgca cttggatcta atattggaga 86581 tagagaaacg tatttaaggc aagcagtggc tttactgcat cagcatgctg cggtgacagt 86641 cactaaagtg tcgtctattt acgaaactga cccggtcgga tacgaagatc aagctcaatt 86701 tttgaatatg gctgttgaaa tcaagacatc attgaaccct tttgaactcc ttgaactgac 86761 gcagcagata gaaaatgaat taggcagaac aagggaagta agatgggggc cgcggacggc 86821 agaccttgac attttgttat ttaatcgtga aaatattgaa acagagcaac taattgttcc 86881 gcatccgaga atgtatgagc gtttgtttgt ccttgcgccg cttgcggaaa tttgccagca 86941 ggttgaaaaa gaggctacaa gcgccgaaac agaccaagaa ggtgtaagag tatggaagca 87001 gaaatctggg gtagacgaat tcgtgcattc agaaagctga aaggttatac tcaagaagga 87061 tttgcaaaag cattaggtat atcagtttct attctcggcg aaattgaacg cggaaaccga 87121 ttgccgtctg ctgccatcat tcaagatgca gcagatgttt taaatataag tgcggacgaa 87181 ttggcgccgc cagaaaaata gaacaaatga aaggaggaga aaaattgttc aaaatcggag 87241 atattcaatt gaaaaaccgg gttgtgctcg cacctatggc tggtgtctgc aactctgcgt 87301 tcagattgac tgtaaaggaa ttcggagccg gattggtatg cgctgaaatg gtcagtgaca 87361 aagcgatcct ttacaacaat gcaagaacaa tgggtatgct ttatattgat gaacgtgaga 87421 aaccactgag ccttcaaatt ttcggaggaa aaaaggaaac ccttgtggaa gcggcgaagt 87481 ttgtagacca aaacacaact gctgatatca ttgatattaa catgggatgt cccgtgccga 87541 agattacaaa atgcgatgcg ggagccaaat ggcttctcga tcctgataag atttacgaaa 87601 tggtttctgc agtagtggat gctgttaata agccagttac agtgaaaatg agaatgggct 87661 gggatgaaga ccacattttc gcagtgaaaa atgcacaggc tgtagaacgt gcgggcggta 87721 aagcagtggc gcttcacggc cgtacgagag tgcagatgta cgaaggaacg gcaaactggg 87781 atatcatcaa agaagtaaaa caatcagtat cgattccggt tatcggaaac ggcgatgtta 87841 agacaccgca ggatgctaag cgtatgctcg atgagacagg agtagacggg gtcatgatcg 87901 gacgcgctgc attgggtaac ccgtggatga tttaccgtac ggttcagtat cttgaaacag 87961 gtaaattaaa agaagagccg caagtacgcg aaaaaatggc cgtatgcaaa ctgcatcttg 88021 accgcctgat tgacttaaaa ggtgaaaacg tagcggtaag agaaatgaga aagcacgctg 88081 catggtatct gaaaggcgtg aaaggcaatg cgaacgttcg taatgaaatc aatcattgcg 88141 agacgagaga agagtttgta cagcttttag atgcatttac ggttgaagtt gaggcaaaag 88201 agcttcaaaa tgcaaaagta ggataatact cacctctatt tgctgctcac tgctagtttt 88261 acgctggcag tttttctgct tttttcatga aacaatatct gtaatggagt gataacaatg 88321 agtcaagaag agcataacca tgaagaattg aatgatcagc tgcaagtcag acgcgataaa 88381 atgaatcagc tgagagataa cggcatcgat ccattcggcg cacgttttga aagaactcat 88441 cagtctcaag aagttatttc ggcatatcaa gatctaacca aagaagagtt agaagaaaaa 88501 gcgattgaag ttacaatcgc aggccgcatg atgacaaaac gcggcaaagg aaaagccggc 88561 tttgcccatc ttcaggattt agaaggccaa atccaaatct acgtaagaaa agacagtgtc 88621 ggtgacgacc aatatgaaat cttcaagtct tctgacctcg gtgatcttat cggcgtaacc 88681 ggaaaagtct tcaaaacaaa tgtaggcgaa ttgtctgtta aagcaacttc ctttgaattg 88741 ctgacaaaag cgcttcgtcc gcttcctgac aaataccatg gtttaaaaga cgttgagcag 88801 cgctaccgtc agcgctatct ggatcttatc gtaaacccag acagcaaaca tacgttcatt 88861 acacgaagca agatcattca agctatgaga aggtaccttg atgatcatgg atacttagaa 88921 gtagaaacac ctacaatgca cagcattcct gggggagctt ctgcacgtcc gtttatcact 88981 caccacaacg cgttagacat tccactctat atgcgtattg ctatcgaact gcacctaaaa 89041 cgtctaattg tcggcggttt agaaaaagta tatgaaatcg gccgtgtttt ccgtaacgaa 89101 ggtgtctcta cacgccataa ccctgaattt acaatgattg agttatatga agcatatgcg 89161 gactataaag atatcatgag cttaactgaa aaccttgtcg ctcatatcgc ccaagaagtg 89221 cttggcacaa ctacgattca atacggggaa gagcaaatcg accttaaacc ggagtggaaa 89281 agaatccata tggttgacgc agtcaaagaa gcgaccggcg ttgatttctg ggaagaggtt 89341 actgttgagc aggcgcgtga atatgcaaaa gaacatgaag tagaaattaa agactctatg 89401 acagtaggcc atatcatcaa cgaattcttc gaacaaaaaa ttgaagaaac gcttattcag 89461 ccaacgttta tttacgggca tcctgtagaa atttctcctc ttgctaagaa aaaccctgag 89521 gacccgcgtt ttacagaccg ttttgagctg tttatcgttg gccgtgaaca tgccaacgcg 89581 tttacagagc tgaatgatcc tattgatcaa agagaacgct ttgaagcgca attaaaagag 89641 cgtgaagccg gtaatgatga agctcattta atggatgaag actttgttga agctctggaa 89701 tacggtatgc cgccaacagg aggtttaggc atcggtatcg accgtctggt tatgctgctg 89761 acgaatgccc cttctattcg cgatgtgctg ttattcccgc aaatgagaca acgctaataa 89821 aaaagagcgg tatcctccat agggaaagga tgccgctctt tttaaatccc ttagtatttc 89881 ttcaaaaaaa ctattgcact attatttact aggtggtata ttattattcg ttgccgctaa 89941 acaaggcgat aacgaaaaaa agaacttcaa aaaaagttat tgacttcact gagtcaacga 90001 gttataataa taaagtcgct tgaacgaagt gaacaaaatg atctttgaaa actaaacaag 90061 acaaaacgta cctgttaatt cagtttttaa aaatcgcaca gcgatgtgcg tagtcagtca 90121 aactacttta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc gtgcctaata 90181 catgcaagtc gagcggacag atgggagctt gctccctgat gttagcggcg gacgggtgag 90241 taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg ggctaatacc 90301 ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta ccacttgcag 90361 atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc aacgatgcgt 90421 agccgacctg agagggtgat cggccacact gggactgaga cacggcccag actcctacgg 90481 gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa cgccgcgtga 90541 gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt gccgttcgaa 90601 tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt gccagcagcc 90661 gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg gctcgcaggc 90721 ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat tggaaactgg 90781 ggaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa tgcgtagaga 90841 tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc tgaggagcga 90901 aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa cgatgagtgc 90961 taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc actccgcctg 91021 gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca caagcggtgg 91081 agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac atcctctgac 91141 aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca tggttgtcgt 91201 cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgatcttagt 91261 tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga ggaaggtggg 91321 gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta caatggacag 91381 aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc tcagttcgga 91441 tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg atcagcatgc 91501 cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga gagtttgtaa 91561 cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg acagatgatt 91621 ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac ctcctttcta 91681 aggatatttt acggaatata agaccttggg tcttataaac agaacgttcc ctgtcttgtt 91741 tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa cagtagacat 91801 cacattcaag taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg 91861 gcgcacggtg gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc 91921 ttcggggagc tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc 91981 gtaatggagt ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact 92041 gaaacatcta agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc 92101 gaaacgggat tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg 92161 gagttacaaa ggaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca 92221 gccctgtagt caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga 92281 aattccgtcg gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata 92341 gtgaaccagt accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc 92401 tgaaaccgtg tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta 92461 gaatgaaccg gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg 92521 aaagcgagtc tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta 92581 cccatgtcca gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga 92641 aaagtgcggg gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg 92701 ttctctccga aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg 92761 attggactag gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact 92821 tatccttggg agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga 92881 ccgccagcta aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca 92941 accaggatgt tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg 93001 agtgactctg cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc 93061 ttcgaacagt ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg 93121 agcgcttaga agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac 93181 cgaatgccta aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc 93241 gaggccgaaa ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca 93301 tttgagcaat ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca 93361 agcagttagg ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag 93421 cgaaatatag tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga 93481 gaggtgcccg taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag 93541 agaactctcg ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct 93601 gttagggtgc aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa 93661 cacaggtctc tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga 93721 aggttaagag gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg 93781 ccgtaactat aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac 93841 gaaaggcgca acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg 93901 tgaagatgca ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg 93961 atattgaatg ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca 94021 gcttcggtgg aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc 94081 ccttatcggg cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa 94141 aaggtaacgg aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta 94201 aaggcacaag ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt 94261 agtgatccgg tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg 94321 ataacaggct tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc 94381 ggctcatcgc atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag 94441 cggtacgcga gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg 94501 caggaaattt gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt 94561 gtaccagttg ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg 94621 aaagcatcta agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag 94681 atccctgaaa gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct 94741 gacagatact aatcgatcga ggacttaacc atatttttga atgatgtcac atctgttatc 94801 tagttttgag agaacactct caatttgttt ggtggcgata gcgaagaggt cacacccgtt 94861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 94921 gtgagagtag gacgccgcca agcaattgca cgttagtgca attatggagg attagctcag 94981 ctgggagagc atctgcctta caagcagagg gtcggcggtt cgagcccgtc atcctccacc 95041 attatgccgg tgtagctcaa ttggtagagc aactgacttg taatcagtag gttgggggtt 95101 caagtcctct tgccggcacc acttttatat gatataatac tcaagtctct tgtagaagag 95161 ccattagctc agttggtaga gcatctgact tttaatcaga gggtcgaagg ttcgagtcct 95221 tcatggctca ccattttacg cgggtgtggc ggaattggca gacgcgctag acttaggatc 95281 tagtgtcttt atgacgtggg ggttcaagtc ccttcacccg cattatatag gataacagtt 95341 agaaaaactg gacatcctgt ctgcggaagt agttcagtgg tagaacacca ccttgccaag 95401 gtgggggtcg cgggttcgaa tcccgtcttc cgctccaact ataccatcca cgccggggtg 95461 gtggaattgg cagacacaca ggacttaaaa tcctgcggta ggtgactacc gtgccggttc 95521 aagtccggcc ctcggcatta tgttttgcgc ccgtagctca attggataga gcgtttgact 95581 acggatcaaa aggttagggg ttcgactcct ctcgggcgcg ccatatcttt taatagaata 95641 gataggaaat cgggaagtag ctcagcttgg tagagcacat ggtttgggac catggggtcg 95701 caggttcgaa tcctgtcttc ccgaccattt ttttatgggg ccttagctca gctgggagag 95761 cgcctgcttt gcacgcagga ggtcagcggt tcgatcccgc taggctccac caaaagtttt 95821 taaaaaagtt gttgactttg aagaagtgac gttgtatact aataaagttg ctttaacaaa 95881 gcggacaaac aaaatgatct ttgaaaacta aacaagacaa aacgtacctg ttaattcagt 95941 ttttaaaaat cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat 96001 cctggctcag gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg 96061 gagcttgctc cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta 96121 agactgggat aactccggga aaccggggct aataccggat ggttgtttga accgcatggt 96181 tcaaacataa aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag 96241 ttggtgaggt aacggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc 96301 cacactggga ctgagacacg gcccagactc ctacgggagg cagcagtagg gaatcttccg 96361 caatggacga aagtctgacg gagcaacgcc gcgtgagtga tgaaggtttt cggatcgtaa 96421 agctctgttg ttagggaaga acaagtaccg ttcgaatagg gcggtacctt gacggtacct 96481 aaccagaaag ccacggctaa ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg 96541 ttgtccggaa ttattgggcg taaagggctc gcaggcggtt tcttaagtct gatgtgaaag 96601 cccccggctc aaccggggag ggtcattgga aactggggaa cttgagtgca gaagaggaga 96661 gtggaattcc acgtgtagcg gtgaaatgcg tagagatgtg gaggaacacc agtggcgaag 96721 gcgactctct ggtctgtaac tgacgctgag gagcgaaagc gtggggagcg aacaggatta 96781 gataccctgg tagtccacgc cgtaaacgat gagtgctaag tgttaggggg tttccgcccc 96841 ttagtgctgc agctaacgca ttaagcactc cgcctgggga gtacggtcgc aagactgaaa 96901 ctcaaaggaa ttgacggggg cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 96961 cgcgaagaac cttaccaggt cttgacatcc tctgacaatc ctagagatag gacgtcccct 97021 tcgggggcag agtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 97081 ttaagtcccg caacgagcgc aacccttgat cttagttgcc agcattcagt tgggcactct 97141 aaggtgactg ccggtgacaa accggaggaa ggtggggatg acgtcaaatc atcatgcccc 97201 ttatgacctg ggctacacac gtgctacaat ggacagaaca aagggcagcg aaaccgcgag 97261 gttaagccaa tcccacaaat ctgttctcag ttcggatcgc agtctgcaac tcgactgcgt 97321 gaagctggaa tcgctagtaa tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct 97381 tgtacacacc gcccgtcaca ccacgagagt ttgtaacacc cgaagtcggt gaggtaacct 97441 tttaggagcc agccgccgaa ggtgggacag atgattgggg tgaagtcgta acaaggtagc 97501 cgtatcggaa ggtgcggctg gatcacctcc tttctaagga tattttacgg aatataagac 97561 cttgggtctt ataaacagaa cgttccctgt cttgtttagt tttgaaggat cattccttcg 97621 aaacgtgttc tttgaaaact agataacagt agacatcaca ttcaagtaat acaagatatc 97681 acatagtgat tctttttaac ggttaagtta gaaagggcgc acggtggatg ccttggcact 97741 aggagccgat gaaggacggg acgaacaccg atatgcttcg gggagctgta agcaagcttt 97801 gatccggaga tttccgaatg gggaaaccca ccactcgtaa tggagtggta tccatatctg 97861 aattcatagg atatgagaag gcagacccgg ggaactgaaa catctaagta cccggaggaa 97921 gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa cgggatcagc ccaaaccaag 97981 aggcttgcct cttggggttg taggacactc tgtacggagt tacaaaggaa cgaggtagat 98041 gaagaggtct ggaaaggccc gccataggag gtaacagccc tgtagtcaaa acttcgttct 98101 ctcctgagtg gatcctgagt acggcggaac acgtgaaatt ccgtcggaat ccgggaggac 98161 catctcccaa ggctaaatac tccctagtga ccgatagtga accagtaccg tgagggaaag 98221 gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa accgtgtgcc tacaagtagt 98281 cagagcccgt taacgggtga tggcgtgcct tttgtagaat gaaccggcga gttacgatcc 98341 cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag cgagtctgaa tagggcgcat 98401 gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca tgtccagggt gaagttcagg 98461 taacactgaa tggaggcccg aacccacgca cgttgaaaag tgcggggatg aggtgtgggt 98521 aggggtgaaa tgccaatcga acctggagat agctggttct ctccgaaata gctttagggc 98581 tagcctcaag gtaagagtct tggaggtaga gcactgattg gactaggggc ccctaccggg 98641 ttaccgaatt cagtcaaact ccgaatgcca atgacttatc cttgggagtc agactgcgag 98701 tgataagatc cgtagtcgaa agggaaacag cccagaccgc cagctaaggt cccaaagtat 98761 acgttaagtg gaaaaggatg tggagttgct tagacaacca ggatgttggc ttagaagcag 98821 ccaccattta aagagtgcgt aatagctcac tggtcgagtg actctgcgcc gaaaatgtac 98881 cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg aacagtggta ggagagcgtt 98941 ctaagggctg tgaagccaga ccggaaggac tggtggagcg cttagaagtg agaatgccgg 99001 tatgagtagc gaaagagggg tgagaatccc ctccaccgaa tgcctaaggt ttcctgagga 99061 aggctcgtcc gctcagggtt agtcgggacc taagccgagg ccgaaaggcg taggcgatgg 99121 acaacaggtt gatattcctg taccacctcc tcaccatttg agcaatgggg ggacgcagga 99181 ggatagggta agcgcggtat tggatatccg cgtccaagca gttaggctgg gaaataggca 99241 aatccgtttc ccataaggct gagctgtgat ggcgagcgaa atatagtagc gaagttcctg 99301 attccacact gccaagaaaa gcctctagcg aggtgagagg tgcccgtacc gcaaaccgac 99361 acaggtaggc gaggagagaa tcctaaggtg atcgagagaa ctctcgttaa ggaactcggc 99421 aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta gggtgcaagc ccgagagagc 99481 cgcagtgaat aggcccaggc gactgtttag caaaaacaca ggtctctgcg aagccgtaag 99541 gcgaagtata ggggctgacg cctgcccggt gctggaaggt taagaggagc gcttagcgta 99601 agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt aactataacg gtcctaaggt 99661 agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa ggcgcaacga tctgggcact 99721 gtctcaacga gagactcggt gaaattatag tacctgtgaa gatgcaggtt acccgcgaca 99781 ggacggaaag accccgtgga gctttactgc agcctgatat tgaatgttgg tacagcttgt 99841 acaggatagg taggagcctt ggaaaccgga gcgccagctt tggtggaggc atcggtggga 99901 tactaccctg gctgtattga ccttctaacc cgccgccctt atcgggcggg gagacagtgt 99961 caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg taacggaggc gcccaaaggt 100021 tccctcagaa tggttggaaa tcattcgcag agtgtaaagg cacaagggag cttgactgcg 100081 agacctacaa gtcgagcagg gacgaaagtc gggcttagtg atccggtggt tccgcatgga 100141 agggccatcg ctcaacggat aaaagctacc ccggggataa caggcttatc tcccccaaga 100201 gtccacatcg acggggaggt ttggcacctc gatgtcggct catcgcatcc tggggctgta 100261 gtcggtccca agggttgggc tgttcgccca ttaaagcggt acgcgagctg ggttcagaac 100321 gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg aaatttgaga ggagctgtcc 100381 ttagtacgag aggaccggga tggacgcacc gctggtgtac cagttgttct gccaagggca 100441 tcgctgggta gctatgtgcg gacgggataa gtgctgaaag catctaagca tgaagccccc 100501 ctcaagatga gatttcccat tccgcaagga agtaagatcc ctgaaagatg atcaggttga 100561 taggtctgag gtggaagtgt ggcgacacat ggagctgaca gatactaatc gatcgaggac 100621 ttaaccatat ttttgaatga tgtcacatct gttatctagt tttgagagaa cactctcaat 100681 ttgtttggtg gcgatagcga agaggtcaca cccgttccca taccgaacac ggaagttaag 100741 ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggacg ccgccaagca 100801 agcttaaacc cagctcaatg agctgggttt tttgtatttt ggtttattgg tatcataaaa 100861 ttccacttaa ctgtataata taataacttt ataccgaatt ttaaatcagc aatcaggttt 100921 tgtggaccgg gaaaatggaa ataatgaagg atagagcgag aaagttgaaa attctcgaga 100981 aacggcttat agtaagatta aagtcaaata tagtcaaagt cagtaaagga gggggttgag 101041 tgggacataa tatttctgac atcattgaac aatatttaaa acgagtgtta gatcaaaatg 101101 gcaaggaaat tttagagatt aaacgaagtg aaattgcaga taaatttcaa tgcgttcctt 101161 cccaaataaa ttatgtcatc aacaccagat ttacaagcga aagaggatat attgttgaga 101221 gcaaacgcgg gggcggcggt tacatcagaa tcattaaaat taaaatgaac aatgaagttg 101281 tcctgatcaa taatataatt tctcaaatta atacccattt gtctcaagca gcctctgatg 101341 acattatttt aaggctatta gaagacaagg taatttcaga aagagaagca aaaatgatgg 101401 tcagcgtaat ggaccgctca gttttacaca ttgacttacc tgaacgtgat gaattaagag 101461 cgagaatgat gaaggcaatg ctgacttctt taaaattaaa ataagcgggt gaaaagattg 101521 atttgtcaag agtgccacga gagaccagcc acttttcact ttacaaaggt tgttaacgga 101581 gaaaaaatag aagttcatat ttgtgaacaa tgtgccaaag aaaatagtga ttcatatggt 101641 ataagtgcaa atcagggttt ctctattcat aatttacttt cgggtttact gaacatggat 101701 tcttcatttc aaaatgcagg aactcaaatg ttcagtcact cggagcaaat atctgcttgt 101761 ccgaaatgcg gaatgacttt tcagcaattc agaaaaattg gccgttttgg atgttctgaa 101821 tgttacaaaa catttcatag caacattaca ccaatcctac gtaaagtgca cagcggaaac 101881 actgtgcatg caggtaagat accgaaacga ataggcggca atcttcatgt cagacggcag 101941 attgatatgc taaaaaagga attagaatcc ttaatccatc aagaagaatt tgaaaatgca 102001 gctcatgtaa gagatcaaat tcgtttatta gaacaatcac tcaaaagtac agatagtgag 102061 gaggaacagg agtaatgtcg ctaaagcatt ttattcagga cgcactaagc agttggatga 102121 agcagaaagg acctgaaagt gacattgtac tcagcagccg catacgttta gcaagaaact 102181 ttgagcatat tcggttccct acgcggtatt ccaatgaaga agcctcatcc atcatacagc 102241 aatttgaaga tcagttttca gagcaagaaa ttcccggaat cggcaaattt gttttgatta 102301 gaatgaatga tgcacagcct ttagaaaagc gtgtacttgt tgaaaaacat ctaatcagcc 102361 cgaatttgac agagtctcct tttggcggct gtttgctttc tgaaaatgag gaagtaagcg 102421 tcatgctaaa tgaagaggac catattagaa ttcagtgtct tttccctgga tttcagcttt 102481 tagaagcaat gaaagccgca aaccaggtcg acgactggat tgaagaaaaa gttgattatg 102541 cattcaatga gcaaagagga tacttaacca gctgtcctac aaacgtaggt actggtttaa 102601 gggcttcggt catgatgcat ctgccggcgc tggttttaac taggcaaata aatcgaatta 102661 taccggcaat taatcaatta ggcttagttg ttagaggaat ttatggggaa ggcagcgaag 102721 cagtagggaa tatctttcaa atttcaaatc agatcacgct tggtaagtca gagcaggata 102781 ttgtagagga tcttaacagt gttgctgctc agttgattga acaagaacga tctgcccgag 102841 aagcgattta tcaaacttct aaaatcgaac ttgaggatcg ggtatatcgg tcatatgggg 102901 tcttgtctaa ttgccggatg atagaatcga aagaaactgc aaagtgcctt tcagatgttc 102961 ggttaggcat agacttaggc ataataaaag gactttcaag caacatactt aacgaactta 103021 tgattttgac gcagccaggg tttttacagc aatactcggg aggcgctttg cgaccgaacg 103081 aaagggacat tcgaagagcg gctctcatca gagaacggct tcacttagaa atgaatggga 103141 aaagacagga ggatgaatcg atatgatgtt tggaagattt acagaacgag ctcaaaaagt 103201 actggcgcta gcacaggaag aagcacttcg gttaggtcat aataacattg gcactgagca 103261 tattttatta ggactggtaa gagaaggaga gggcattgct gctaaagctc ttcaagcgct 103321 tggactcggt tcagaaaaaa ttcagaaaga agtagaaagt ttgatcgggc gcgggcagga 103381 aatgtctcaa acgattcatt atactcctag agctaaaaaa gtcattgagc tttcaatgga 103441 tgaggcaaga aaactcggtc attcttatgt gggaacagaa catattcttc ttggtctgat 103501 tcgtgaagga gaaggtgttg ctgcgagagt tctgaataat ctcggtgtca gcttaaataa 103561 agcaagacag caggtgctcc agcttctagg aagtaatgaa acaggatcat cagcggcagg 103621 aacaaacagc aatgcgaata cgcctacgct tgacagcttg gcaagagact taactgctat 103681 tgcgaaggaa gacagccttg accctgtaat cggcagaagc aaggagatcc agcgtgtcat 103741 tgaagtgtta agccgcagaa cgaaaaacaa ccctgttctc attggggaac caggtgtagg 103801 taaaacggct atcgcagaag gtttggcaca gcaaattatc aataatgaag tacccgaaat 103861 tttgcgtgat aaacgtgtga tgacattaga catgggaaca gttgttgccg gcacaaaata 103921 ccgcggagaa tttgaggatc gcctgaagaa ggtcatggat gaaattcgcc aggcaggaaa 103981 tatcattcta ttcatcgatg agctccatac attaatcggg gcaggcggag cagaaggtgc 104041 tattgatgca tctaatattt taaaaccttc acttgctcgt ggcgaactcc aatgtattgg 104101 tgcaacgact cttgatgagt accgtaaata tattgaaaaa gatgcagcac tggaacgccg 104161 ttttcagccg attcaggttg atcagccatc tgtagatgaa agtattcaaa ttttacaagg 104221 tctgcgtgac agatacgaag cccaccaccg cgtttctatc actgatgatg ccattgaagc 104281 tgcggttaag ctttctgaca gatatatttc tgaccgcttc cttccggata aagcaattga 104341 cttgatcgat gaagcgggtt caaaggtgag actgcgctca tttacaacgc ctcctaactt 104401 aaaagagctt gagcagaagc ttgatgaggt tcgtaaagag aaggatgcgg cagtgcaaag 104461 ccaagagttt gaaaaagctg cttccttgcg tgatactgaa caacgcctgc gcgagcaagt 104521 agaggatacg aagaaatcat ggaaagagaa gcaagggcag gaaaactcag aggttactgt 104581 ggatgatatt gcgatggttg tatccagctg gaccggtgtg cctgtatcta aaatcgccca 104641 aactgaaact gataagcttc tcaatatgga aaacattctt cactcccgtg tcatcggcca 104701 ggatgaagca gttgtagcgg ttgcaaaagc cgtcagacgt gcaagagcag gattgaaaga 104761 tcctaaacgc ccaatcggct cattcatttt cttaggccct acaggtgtag gtaaaacaga 104821 acttgcacga gcacttgctg aatccatttt tggcgatgaa gaatccatga tcagaattga 104881 tatgtctgaa tacatggaaa aacattcaac ttcaagactt gttggttcac ctccgggtta 104941 tgtgggatat gatgaaggcg gtcaattgac agagaaagtc agaagaaaac cttactctgt 105001 cgtgcttctt gatgagatcg agaaagcgca ccctgatgtc ttcaatatcc ttctgcaagt 105061 tcttgaagac ggacgattga ctgattctaa aggacgcaca gtcgatttcc gcaataccat 105121 tctgatcatg acatcaaacg tcggagcaag tgagctaaaa cgcaataaat atgtcggctt 105181 taacgttcag gatgaaactc aaaatcataa agacatgaaa gataaagtga tgggtgaatt 105241 aaaacgagcg ttcagacctg agttcatcaa ccgtattgat gaaatcattg tcttccattc 105301 acttgagaaa aaacatctca ctgagattgt gtcattaatg tctgatcaat taacgaaacg 105361 cctgaaagaa caagatcttt ctatcgaatt gacagatgct gcaaaagcga aagtcgcgga 105421 agagggcgtt gacctggaat acggtgcccg tccgttaaga agagcgatcc aaaaacatgt 105481 cgaggatcgt ttatctgaag aactcctcag aggaaatatt cataaaggac agcatattgt 105541 tcttgatgta gaagatggcg aatttgtcgt aaaaacgact gctaaaacga attaatatag 105601 aagacggaaa tgaggcatac agcatgtaag tgtatgcctc actttcatat caagaaatag 105661 aacaagggag aggtcttaca ctatatatgg ctaaaacaaa atcgaagttc atctgccaat 105721 cctgcggcta cgagtctcca aaatggatgg ggaaatgtcc gggctgtggt gcttggaata 105781 caatggtgga agaaatgatt aaaaaagcac cggccaatcg gagagcggct ttttctcatt 105841 ctgttcaaac tgtacagaaa ccttcaccta ttacatcaat cgaaacatca gaagaacccc 105901 gcgtcaaaac ccagcttggc gagtttaaca gagtactcgg cggaggtgtc gttaaaggct 105961 ccctcgtttt aattggcggt gatcctggta tcggaaagtc aacgctatta ctgcaggttt 106021 ccgctcaatt atcaggctca tcaaacagtg tcctgtatat ttcgggagaa gaatctgtaa 106081 agcaaacgaa gctgcgagca gaccgtctcg gcattaataa tccgtcactg catgttttat 106141 ctgaaaccga tatggagtat atttcgtctg ctatacaaga gatgaatcca tcgtttgtcg 106201 ttgttgactc tattcaaacg gtttaccaaa gcgatattac atctgctcca ggcagtgtgt 106261 cacaggtcag agaatgtacc gctgagctga tgaaaattgc aaaaacaaaa ggtattccga 106321 tttttatcgt agggcacgtg acgaaagaag ggtctattgc aggtccgaga ctgttggagc 106381 atatggttga cactgtttta tattttgaag gagaacgcca ccatactttc cgtattttgc 106441 gggctgtaaa aaaccgtttc ggatctacaa acgaaatggg cattttcgaa atgcgggaag 106501 aggggctcac tgaggttttg aatccttcgg aaattttctt agaagaacgc tctgctggtt 106561 ccgcaggctc gagtatcact gcctctatgg agggcactag accgattctc gttgaaattc 106621 aggcactcat ctcgccaaca agttttggca acccaaggcg tatggcaacg ggaatagacc 106681 ataacagggt ttctctgtta atggctgtgt tagaaaaaag agttggactg ctgctgcaaa 106741 atcaggatgc ttatttgaaa gtggctggcg gcgttaagct tgatgaaccg gcaattgatc 106801 ttgcgattgt gattagtatt gcatcaagct ttagagacac acctccaaat cctgcagatt 106861 gttttattgg agaagtggga ttaaccggag aagtccggcg ggtttcaaga attgaacagc 106921 gtgtgaaaga agcggcaaag cttggtttta aacgcatgat catacccgcg gcaaatctgg 106981 atggatggac aaaaccaaaa gggattgagg ttatcggagt agcaaatgtt gcagaagcgc 107041 ttcgtacttc attaggagga taatagatgg aaaaagagaa aaaaggggcg aaacacgagt 107101 tagacctgtc atctatattg cagtttgttg ctccgggtac accgctcaga gcggggatgg 107161 aaaacgtctt gagagcaaat acaggcggtc tgattgttgt tggatataat gataaagtaa 107221 aagaagtggt ggacggcggc tttcacataa acacggcttt ttctccggcg catttatatg 107281 agctggctaa aatggatgga gcgatcattt taagtgattc tggtcaaaag atcctatacg 107341 cgaatactca gctgatgccg gatgccacaa tttcttcatc agaaacagga atgcggcaca 107401 gaactgccga aagagtagct aagcaaactg gctgtcttgt aatcgccatt tctgaaagaa 107461 gaaatgtcat aacgttatat caggaaaaca tgaagtatac actaaaagac ataggattta 107521 ttttaaccaa ggcgaaccaa gccattcaaa cacttgaaaa atataagaca atcctcgata 107581 aaacgattaa tgcactgaac gcgttagagt ttgaggaact tgttaccttc agtgatgtct 107641 tgtctgtcat gcatcgttat gaaatggtac tgagaatcaa aaacgaaatt aatatgtata 107701 tcaaagagct ggggacagaa gggcatctga tcaaactgca agtcattgaa ttgattacgg 107761 atatggaaga agaggccgct ttatttatta aggactatgt aaaagaaaag attaaagatc 107821 cgtttgttct cttgaaggag ctgcaggata tgtccagtta tgatctgctg gatgattcca 107881 ttgtgtataa gcttctcggt taccctgctt ctactaatct tgatgattat gtattgccga 107941 gaggatacag gctgttaaat aagataccgc gtcttccgat gccgattgtt gaaaatgttg 108001 tagaagcatt tggagtcctg ccaaggatta ttgaggcgag tgcagaagaa ttagatgaag 108061 tagagggaat cggtgaagta cgagcccaaa aaatcaaaaa aggattaaaa cgcctgcaag 108121 agaagcatta tttagacaga caactgtgat ttcggttaaa accttatgaa tacgggtata 108181 ttaatgttgg tttttgttta ttctgatatt cgtaggatgc ataagacttt gtgaaattaa 108241 aatgttaaaa aaggaggtgg gggtatgtta aaacgaatag ttcaggcgtt cttcattatt 108301 tttggcggcg ttgttggtat atttttgata cctgaattgt ttgtactgtt aaatatacag 108361 gacatacctt taataacaaa cgcatatacg tctgcggcaa taggagcaat tatctttttt 108421 ctcatcagta tatggggtac agaatacgtt gtgaactggg tgaagtggat agaggattca 108481 ttgttaaaag cgccggttcc agatttgtta tttggaagtc ttggcttagt ttttggactt 108541 ataattgctt atcttatcgt aaatgttatt cctttagaca atatacctta ccgcatattc 108601 agcacaataa ttcctgtatt tttggctttc ttcctcggtt atctcggctt ccaggtgggc 108661 tttaagaaaa aggatgaatt gatcagcctg ttttccattt ccgccagaat gcaaaagaaa 108721 aaaggaacag ctgatgaaga acatgaggtt caagacaaga agctgaaaat tttggacact 108781 agtgttatta ttgatgggag aatagcagat atttgtcaga ctggtttttt agagggagtt 108841 atcgtgattc cgcagtttgt ccttgaggaa ttgcagcata ttgcagactc ttcagatgtt 108901 ttaaaacgaa acagaggacg ccgcggtctt gatatcctga accgcattca gaaagaatta 108961 gacattgaag ttgaaattta cgaaggcgac tttgaagata ttcaggaggt tgacagcaag 109021 ctcgtcaaac ttgctaagct gacatccggg gtcgttgtga cgaatgattt taatttaaat 109081 aaagtgtgcg agcttcagaa ggtagcagta ttaaacatta atgaccttgc caatgcggtt 109141 aagcctgttg tgcttcctgg cgaggaaatg aatgttcagg tcattaagga cgggaaagag 109201 cataatcagg gagttgccta cttggatgac ggtacgatga ttgtcgttga agaaggacgg 109261 aattatatcg gcaagcatat tgatgtactc gtcacaagtg tgctgcagac agcagcggga 109321 cgaatgattt ttgcgaagcc taagctgttg gagaaggcgc tgtaaaggga gaagaaacaa 109381 tgagttatga tgtggtgatt cctgcagccg gacagggaaa gcggatgaag gcagggagaa 109441 ataaactgtt cattgagctg aagggagacc cggtgatcat acacacgtta agagtgtttg 109501 acagccaccg gcagtgcgat aaaatcattt tggtgattaa cgagcaggag cgggagcact 109561 ttcagcaatt gctgtccgat tacccgtttc aaacttcaat tgagcttgtt gcaggcggag 109621 atgagcgaca gcacagtgtg tataaggggc tgaaagccgt aaagcaggaa aagattgtcc 109681 ttgtacatga cggtgcccgt ccatttataa aacatgaaca aattgacgaa ctgatcgcag 109741 aggcggaaca gacaggagcg gccatccttg ctgttccggt aaaagatacg attaaacgcg 109801 ttcaagattt acaagtcagt gagacgattg aacgttcaag cttgtgggct gtccaaacgc 109861 cacaagcttt tcgtctttct ttattgatga aggctcacgc tgaggccgag cgcaagggat 109921 ttttagggac ggatgacgcc agcctcgttg aacagatgga gggcggttcg gtccgtgttg 109981 tagaaggcag ctatacaaat attaagctga cgacgccaga cgatttgacg tcagctgaag 110041 ctatcatgga atcagaaagt gggaataaac atgtttagaa ttggacaagg atttgatgtg 110101 catcaattag tggagggccg tcctctcatt attggcggaa ttgaaatccc gtacgaaaaa 110161 gggctgcttg gccattctga tgcagacgta ttgttgcata ccgtcgctga cgcctgcctg 110221 ggagctgtgg gtgaaggaga cataggcaag cattttcctg acacagatcc cgagttcaag 110281 gacgcagatt ctttcaaatt acttcagcat gtctggggaa tcgtgaaaca gaaggggtat 110341 gtccttggga acattgattg caccatcata gcgcaaaagc cgaagatgct gccgtacata 110401 gaagatatga gaaaaagaat tgctgaaggc cttgaggcag atgtttctca agtaaatgta 110461 aaagcaacaa cgacagaaaa gcttggattt acaggccggg cggaaggaat agcggctcag 110521 gcgacagtac tgatacaaaa aggctaactt gttttgatgc cgggtctatt tggtggtaga 110581 atagattcat acatttttgc ctgaggccat acatgacatg aaaggaagta tttgaaaatg 110641 ggaaacgaag tacgcgtccg ttatgcaccg agtccaaccg gacatttgca tattggaaat 110701 gccagaacgg cgctttttaa ttatttattt gcccgcaatc aaggcggtaa gtttatcatt 110761 cgagttgagg atactgataa aaagcgcaat attgagggcg gagaacaaag ccagctgaat 110821 tatctgaagt ggctaggtat tgactgggat gagagtgtgg atgtcggagg agagtacggt 110881 ccataccgtc agtcagagcg taacgatatc tataaagtgt actatgaaga gcttcttgaa 110941 aaagggcttg cttataaatg ttactgtacg gaagaagagc ttgaaaaaga gcgtgaagaa 111001 cagattgccc gcggagaaat gcctcgttat tccggaaaac acagagacct gactcaggaa 111061 gaacaggaga aatttatcgc cgaaggcaga aaaccaagta ttcgtttccg tgtgccggaa 111121 ggaaaagtca tcgccttcaa cgacatcgta aaaggcgaaa tttcttttga atcagatggc 111181 atcggcgact tcgttattgt gaaaaaggac ggaacgccta cttataactt cgcggtagct 111241 attgatgact acttaatgaa aatgacacac gtgctgcgcg gtgaggatca tatttctaac 111301 acaccgaaac agattatgat ctatcaagca ttcgggtggg atattcctca gttcggacac 111361 atgacgctga ttgtaaacga aagccgtaaa aagctcagca aacgtgatga atccattatt 111421 caattcatcg agcagtacaa agagcttggc tacctgccag aagcgctgtt caactttatc 111481 ggcttgttag gctggtcacc ggttggagaa gaagagcttt tcacaaaaga gcagtttatt 111541 gaaatttttg atgtaaatcg tttatctaaa tcaccagctt tgtttgatat gcataagcta 111601 aaatgggtta acaaccaata tgtgaagaag ctggatcttg atcaggttgt tgaactgacg 111661 cttccgcatt tgcaaaaagc cggcaaagtt ggcactgagc tttctgctga agaacaagaa 111721 tgggttcgta aactgatttc cctgtatcat gagcaattaa gctacggtgc ggaaattgtt 111781 gagctgactg atttgttctt tacggatgag atcgagtata atcaagaagc gaaagctgtt 111841 ctggaagaag aacaggttcc tgaagtgctc agcacattcg cagcgaagct tgaagagctt 111901 gaggagttca ctccggataa tatcaaagca tcgatcaaag cagtgcagaa agaaactggc 111961 cataaaggga aaaaactgtt tatgccgatt cgtgttgctg taacagggca aactcacggt 112021 ccggaactgc cgcaatcaat tgaattgatc ggtaaagaga ctgcaattca gcgtttaaag 112081 aatatctaaa taaatgattg ttgacaggga agagtataaa gctttaggcc attacagaaa 112141 ggatcttcat tggctgagag agatccatga gccgggtttt agaagtgcgc ccttaagacc 112201 tttgaagaac gttttttgaa atcagtattc aaaggcggcc gccgccgtta caggctgaag 112261 ttgggagagc agaagtctgc ttttcaaaca gagtggaacc gcgcggttaa agcgtctctg 112321 tcatgtttac atgcagagac gcttttttta ttgggtagag gaaatcagat agagaaacgg 112381 ggggaagcat gtgtttttta gaatgctcaa agaagacatt gatactgtgt tcgatcaaga 112441 tcccgcagca agaagctatt ttgaagtgat tttaacttat tccggtttac atgctatatg 112501 ggcgcatcgg attgcacatg ctttatataa acgaaaattt tatttccttg cacgccttat 112561 atctcaagta agccgatttt ttaccgggat agaaatccac cccggcgcta caatcgggag 112621 aagatttttc atagaccacg gcatgggggt tgtcattggg gagacatgtg aaatcggcaa 112681 taacgtaacc gtttttcagg gggttaccct cgggggaacg ggaaaagaaa agggaaaaag 112741 gcacccaacg attaaagatg acgcattgat agccacaggt gctaaagtgc tcggttctat 112801 tacggtcggt gaaggctcaa agattggcgc tggttcagta gtgctgcatg atgttcctga 112861 tttttcaaca gttgtcggta tccctggacg ggtcgttgta caaaatggca agaaagtaag 112921 acgcgattta aaccatcagg atttgcccga tccagttgct gaccgcttta agtctttgga 112981 acagcagatt ttagagctga aggcagaact tgaagacaga aaagaaagga tcaatcaaaa 113041 atgacaatca cactttataa tacattgact agacagaagg aaacattcgt tcctcttgaa 113101 gagggaaaag tgaaaatgta tgtatgcgga cccacggttt acaattacat tcatatcggg 113161 aacgcgcgtc cggcaatcgt ttacgatacg gttcgaaact atttagagta taaaggctat 113221 gatgtgcagt atgtctctaa cttcacagac gtagacgata aattaattaa agcggcaaat 113281 gaactcggtg aggatgtacc caccatttca gagcgtttta ttaaagcata ctttgaagac 113341 gtaggtgcgc tcggctgccg aaaagccgac cttcatccgc gagtaatgga gaacatggat 113401 gccattatcg aattcgtaga tcagctcgtg aaaaagggct acgcatatga atcagaaggt 113461 gacgtatatt tcaaaaccag agcatttgaa gggtacggaa agctttctca gcaatcaatc 113521 gatgaactaa gatcaggtgc acgcatccgg gtcggcgaga aaaaagaaga tgctcttgat 113581 ttcgcactgt ggaaagcggc aaaagaagga gaaatctctt gggatagccc ttgggggaaa 113641 gggcgtccgg gctggcacat tgaatgctca gcaatggtga aaaagtatct cggtgaccag 113701 attgatatcc atgcgggcgg acaggattta acattccctc accatgaaaa cgaaattgcg 113761 caatctgagg cgctgacagg caaaacgttt gcgaagtact ggcttcataa tggttatatc 113821 aatattgata atgaaaaaat gtcaaaatca ctaggcaact ttgtgcttgt gcatgacatc 113881 attaaacagc atgatccgca gcttttgaga ttctttatgc tatctgttca ttatcgccat 113941 ccgattaact attcagaaga gcttctggag aatacgaaaa gcgcgttcag ccgtttaaaa 114001 acagcgtaca gcaatcttca gcaccgtctg aacagcagta cgaatttaac cgaagatgac 114061 gatcaatggc ttgaaaaggt tgaagaacac cgcaaagcat tcgaagaaga gatggacgat 114121 gattttaata cggcgaatgc catttcagtc ttgtttgact tagcgaaaca cgccaattat 114181 tatcttcaga aagatcatac ggctgatcat gtgattacgg cgtttattga gatgtttgac 114241 cgcattgttt ctgtcctcgg tttttcgttg ggtgagcagg aacttctcga tcaagagatt 114301 gaagacttaa tcgaaaagcg aaatgaagcg cgccggaatc gcgattttgc attgtcagac 114361 cagatccgcg accagctgaa aagcatgaat atcattcttg aagatacggc tcaaggcact 114421 cgctggaaac ggggagaata acagatgctt gaatttgata cgataaaaga ttctaagcag 114481 cttaacggtc ttgcgcttgc ttatataggt gatgccattt ttgaagtgta tgtcaggcat 114541 cacctgctta agcagggctt taccaaacca aatgatcttc ataagaaatc aagccggatt 114601 gtttcagcaa agtcacaggc tgagatccta ttttttctgc agaatcaatc attttttacg 114661 gaagaagagg aagcggtgct gaaaagaggc agaaatgcca agtcagggac aacacctaaa 114721 aatacagatg ttcagacgta ccgctacagt acagcatttg aagcgcttct gggctacctt 114781 tttctagaga aaaaagagga acgacttagt cagctcgtag ccgaagctat acaattcggg 114841 acgtcaggga ggaaaacaaa tgagtcagca acatgattac gtcataggga aaaatgcagt 114901 gatcgagacg ttaaaatctg atcggaagct gtataagctg tggatggcgg aaaacaccgt 114961 aaagggacaa gcacagcaag tgattgagct tgccaaaaag cagggaatca cgattcaata 115021 cgtcccgaga aaaaaactcg atcaaatggt gacaggacag catcagggcg tagtggcaca 115081 ggttgcagcg tatgaatatg cagaactgga cgatttatat aaagcagccg aagaaaaaaa 115141 tgaacagcct ttcttcctca ttctggacga gcttgaagac cctcataatc ttggttccat 115201 tatgaggaca gcagatgcgg tcggcgctca tggcatcgtc attccaaaac ggagagctgt 115261 cgggctgaca acaacagtgg caaaagcttc aacaggagca attgagcaca ttcctgtagc 115321 aagagtcacc aatttggcac ggacgttaga agagatgaaa gagcggggaa tctgggttgt 115381 cggaacggat gcgtccgcgc gtgaggattt ccgtaatatg gacggcaata tgcctttggc 115441 tctagtcatc ggaagtgaag gaaaagggat gggccgcctt gtgaaggaaa agtgcgattt 115501 tctcattaaa ctcccgatgg ccggaaaggt aacttcacta aatgcatctg tcgcggctgg 115561 tcttttgatg tatgaagtct accggaaacg aaaccctgtg ggagaataaa gacccatgga 115621 tatcctgtta gtagacgggt acaacatgat tggagcctgg ccgcagctga aggatttaaa 115681 agcgaacagt tttgaagagg cgagagacgt actgattcag aaaatggcgg aatatcaatc 115741 gtatacagga aacagggtta ttgttgtttt tgacgcgcat ctcgtaaaag ggcttgagaa 115801 aaaacagacc aaccatagag ttgaagtaat ttttacaaaa gaaaatgaga cggctgatga 115861 gcggatagaa aagctcgctc aggctttgaa taatattgcg actcaaattc acgttgcgac 115921 ctctgactat actgagcagt gggcgatttt cggacagggg gcattgcgga aatcggcccg 115981 ggagcttctg agagaggtag aaacgattga aaggcgaata gagagacggg taagaaaaat 116041 cacttccgaa aagccggcgg gtaaaattgc tttatcggaa gaggttttga aaacgtttga 116101 aaagtggagg cggggagact tagattaagt tgacgctttt ttgcccaata ctgtataata 116161 tttctatcta cgtgcgccgg ggggatcgga gtgaatctac agaacaacaa gggaaaattc 116221 aacaaagagc agttttgcca gttggaggac gagcaggtca ttgaaaaggt tcatgttggg 116281 gacagtgatg cgttagatta cttgattacg aagtaccgaa actttgttcg ggcaaaagca 116341 agatcctatt tcttaatagg ggcggacaga gaggatattg ttcaggaagg catgataggc 116401 ctctataagt ctattcgtga cttcaaagag gacaagctta cctcattcaa agcttttgca 116461 gaattatgta ttacccgcca aattattacc gcaataaaga cagctactcg ccagaaacac 116521 attcctttga attcctacgc ctcattagat aaaccgatct ttgatgaaga atcagaccga 116581 acgctgctgg atgtcatttc aggagcgaaa accttaaatc ctgaggaaat gatcattaat 116641 caggaagaat ttgatgatat tgaaatgaaa atgggagaac tattaagtga tttagagaga 116701 aaagtactcg tcttatatct cgacgggaga agttaccaag agatttctga tgaactgaac 116761 cgacatgtga aatcgatcga caatgccctt cagcgtgtga aacgcaagct ggagaagtac 116821 ttggaaattc gcgaaatcag tttgtaatag gaatttatgc tatattgaca gtatttttct 116881 gactatgata tgttactaaa gataagaact aatgtctatt tagaaaaagg tgtaatgaca 116941 tgagaaaaaa gattacgtta gcatgcaaga catgcggaaa ccgtaattat acgacaatga 117001 agagctctgc atcagcggct gagcgattag aagtaaagaa atactgcagt acttgcaatt 117061 cacatacagc tcatcttgaa acaaaatagt ttttgcgctt ttaaattgtg gaggtctttt 117121 acatgcgtat tatgaaattc tttaaagatg ttgggaaaga aatgaaaaag gtaagctggc 117181 ctaaaggaaa agagttaacg cgttatacca ttacggtaat ttcaacagtt atcttttttg 117241 ttatcttttt tgccctcctt gacacaggaa tttctcaatt aattcgttta atagttgaat 117301 aatgatcagc aatacgtgct ataatagatc ataatattac ttgccaaaac ccgttcagcg 117361 ggttttttat tgtggcttaa aatgaaagtt atcataggct tgccgcctat tttttgaagc 117421 gttatggtaa ttcactaaaa ccaaatgcgg ggagggaagg actggacagt cctgaataga 117481 atggaaaaga attggtatgt tgttcacacg tactctggtt atgagaataa agtaaaagcc 117541 aacttggaaa agcgtgttga atcaatgggg atgcaggata aaattttccg tgtagtcgta 117601 cccgaagaag aagaaacgga tatcaaaaac ggcaagaaaa aagtcgtgaa aaagaaagta 117661 ttccctggtt atgtgcttgt tgaaattgta atgacagacg actcttggta tgtcgtccgc 117721 aacacgccgg gcgttactgg attcgtagga tctgccgggt caggttcaaa accgacgccg 117781 cttcttccgg gggaagcaga aaccattctg aagagaatgg gcatggatga acgaaaaact 117841 gatattgact ttgaactgaa agagacagtg aaagtaatag acggaccttt tgctaacttt 117901 acaggatcaa ttgaagagat tgattatgat aaaagcaagg tcaaagtttt cgttaatatg 117961 tttggccgtg aaacgccggt tgagctggaa tttacccaaa tcgataaatt gtaatgtgaa 118021 aaaacttgaa attgctatat ataaatgata atatagcaaa ggtacgtctt ggacttatcc 118081 aaggcaacta gcatgatatt tcgtcattca tataaagaat gaaaccttga gtgggagggt 118141 ttaccctatt accacatcac ggacttaagg aggtgtgtct cgtggctaaa aaagtagtta 118201 aagttgtaaa attgcaaatt cctgctggaa aagctaaccc agcaccacca gttggacctg 118261 cacttggtca agccggtgtt aacatcatgg gattctgtaa ggagtttaac gctcgtacag 118321 ctgaccaagc tggtttaatc attcctgttg aaatttcggt ttacgaagac cgttcattta 118381 catttattac aaaaactcca cctgctgcag tattgcttaa aaaagcagct ggaattgagt 118441 ctggttctgg tgaaccaaac cgtaataaag tggcaaccgt taagcgcgat aaagtacgcg 118501 aaatcgctga aacgaaaatg cctgacttaa acgcagcaga cgttgaagcg gcaatgcgca 118561 tggttgaagg tactgcccgc agtatgggta ttgtaatcga ggattaattt gtttcttgtc 118621 gggttgcgag ttttaacaag ttcgcaaccc ttattcgtgg gaggttattc cgctataacc 118681 acataaggag gaaattttaa aatggctaaa aaaggtaaaa agtacgttga agctgctaag 118741 cttgtagacc gttctaaagc ttacgacgtc tctgaagcag tagctctcgt taaaaaaaca 118801 aacacagcta aattcgacgc tacagttgaa gtggctttcc gtttaggggt tgaccctcgt 118861 aaaaacgacc agcaaatccg tggagcagtt gtgcttccaa acggaactgg taaaactcag 118921 cgcgttctcg ttttcgcaaa aggcgaaaaa gcgaaagaag ctgaagctgc tggtgcagat 118981 ttcgtaggcg atactgacta catcaacaaa attcaacaag gctggttcga tttcgatgtt 119041 atcgtagcta cacctgacat gatgggtgaa gttggtaaaa tcggtcgtgt acttggacca 119101 aaaggtttaa tgccgaaccc taaaactggt acagttactt tcgaagttga aaaagctatc 119161 ggcgaaatca aagctggtaa agttgaatac cgcgttgata aagctggaaa cattcatgtt 119221 cctatcggta aagtttcttt cgaggatgaa aaacttgttg agaacttcac aacaatgtac 119281 gatacaatcc ttaaagctaa acctgctgca gctaaaggcg tttacgtgaa aaacgttgct 119341 gtaacttcta ctatgggacc tggtgtcaaa gtagactctt caacttttaa cgtaaaataa 119401 tattgacatg acatcaacat tctgatatta ttcaaaatgt tgtaaaatag aatatcattt 119461 ataccgtaga cagtaggggc ctaaccgctt aattatccta ccgaggtgta tattatcaca 119521 gctattacgt tacgtatgct tgtatataca gcctccatgt ctcatggagg ctttttatat 119581 ggaatccgtc gtctcagtcg tgatcaccta acggtataag tgttacacaa gaatctacag 119641 gaggtgtaac catgagcagc gcaattgaaa caaaaaaagt tgttgttgaa gaaattgctt 119701 ctaaactgaa agaaagtaaa tcaacgatca tcgttgacta tcgcggactt aacgtttctg 119761 aagtaactga acttcgtaaa cagcttcgcg aagctaacgt tgagttcaaa gtttacaaaa 119821 atacgatgac tcgccgtgcg gttgaacaag ctgagcttaa tggtttgaat gatttcttaa 119881 ctggaccgaa cgcgatcgca ttcagcactg aagatgttgt cgctccggct aaagttctta 119941 atgacttcgc taaaaatcac gaagctcttg aaatcaaagc tggcgttatc gaaggtaaag 120001 tttctactgt tgaagaagtg aaagctcttg ctgaacttcc atcacgcgaa ggcttgcttt 120061 ctatgttgct tagcgtactt caagctccag ttcgcaacct tgctcttgct gcaaaagctg 120121 tggcagaaca aaaggaagaa caaggcgctt aatctaatca gtttttcata aattaaaaca 120181 aaatggagga attacaaatg gctttaaata tcgaagaaat cattgcttcc gttaaagaag 120241 caactgtact tgaattgaac gacctagtaa aagcaatcga agaagaattt ggcgtaactg 120301 ctgctgctcc tgtagctgta gctggcggag ctgctgctgg cggagctgct gaagagcaaa 120361 gcgaattcga tcttatcctt gctggtgcag gatctcaaaa aatcaaagtt atcaaagttg 120421 tacgtgaaat cactggtctt ggcttgaaag aagctaaaga gcttgttgac aacactccaa 120481 aaccacttaa agaaggtatt gctaaagaag aagctgaaga gcttaaagct aaacttgaag 120541 aagttggcgc ttctgtagaa gttaagtaat cttcacttac ctgtagggga agctcgcttt 120601 tatgaggcga gctttttctt tgccattctt taagccatga aaaaaggagg ttctaataat 120661 gagtgagcac tattattcag aaaaaccttc agtaaaaagc aacaagcaaa cctggtcttt 120721 taggcttcgg aataaagatt tcacgtttac cagcgacagc ggggtttttt ctaaaaaaga 120781 agttgatttc ggctcccgcc tgctgattga ttcttttgaa gagcctgagg ttgagggcgg 120841 cattttagat gtaggctgcg gatacggccc gattggttta tcgctcgcca gcgactttaa 120901 agaccggacc atccacatga ttgacgttaa tgagagagcc gtagaactat caaatgaaaa 120961 tgcggaacag aacggaataa caaacgttaa gatttatcaa agcgatttgt tttcaaacgt 121021 tgattctgct caaacatttg cttctattct tacaaatccc ccaatccgag ccggaaaaaa 121081 agttgtccat gctatctttg agaaaagcgc tgaacactta aaagcttcag gtgaattgtg 121141 gatcgtcata cagaaaaagc aaggcgcgcc ttctgccatt gaaaagctcg aggaactgtt 121201 cgatgaagtt tccgtcgttc aaaaaaagaa aggctattat atcataaaag caaaaaaagt 121261 ttgactcggt attttaacta tgttaatatt gtaaaatgcc aatgtatata ttttgcttga 121321 tatgatgaat tgtcaatatc tatgtataaa ttatacaagt atggaaatgc taataaaatc 121381 ggtatttgtt tttggatgtg gttttcttaa ttagaaaccc ttttttcttt tgtcttgtaa 121441 aagtattttc tttctttgga agaaatgctt attacacata taatacgcat gatttgaggg 121501 gtgaatcagt tgacaggtca actagttcag tatggacgac accgccagcg cagaagctat 121561 gctcgcatta gcgaagtgtt agaattacca aatctcattg aaattcaaac ctcttcttat 121621 cagtggtttc ttgatgaggg tcttagagag atgtttcaag acatatcacc aattgaggat 121681 ttcactggta acctctctct tgagttcatt gattatagtt taggtgagcc taaatatcct 121741 gtagaggaat caaaagaacg tgatgtgact tactcagctc cgctaagagt gaaggttcgt 121801 ttaattaaca aagaaactgg agaggtaaaa gaccaagatg tcttcatggg tgatttccct 121861 attatgacag atacaggtac ttttatcatt aacggtgcgg aacgtgttat cgtttcccag 121921 cttgttcggt ctccaagtgt atatttcagt ggtaaagtag acaaaaacgg taaaaaaggt 121981 tttaccgcaa ctgtcattcc aaaccgtggc gcatggttag aatacgaaac tgatgcgaaa 122041 gatgttgttt atgtccgcat tgatcgcaca cgtaagttgc cggttacggt tcttttgcgt 122101 gctctcggct tcggctccga tcaagagatt cttgatctca taggagaaaa cgaatacctg 122161 cgaaatacgc ttgataaaga taacacagaa aacagcgaca aagcgttgct ggaaatttac 122221 gagcgtctcc gtcctggaga gccgcctaca gtagaaaatg cgaaaagctt gcttgattct 122281 cgtttctttg atccgaaacg atacgatctt gccaatgtag gacgctataa aattaataaa 122341 aaacttcata ttaagaatcg cctcttcaat cagagacttg ctgaaacgct tgttgatcct 122401 gaaacaggag aaatccttgc tgaaaaaggc cagattcttg atagaagaac gcttgataaa 122461 gtactgccat acttagaaaa cggaatcggt tttagaaagc tgtatccgaa tggcggcgtt 122521 gttgaagatg aagtgactct tcaatcaatt aaaatctttg ctccgactga tcaagaagga 122581 gaacaggtta tcaatgtaat cggcaatgct tacatcgaag aagagattaa aaacatcacg 122641 cctgctgata ttatttcttc aatcagctac ttcttcaacc tgctgcacgg agtaggcgac 122701 acagatgata tcgatcatct tggaaaccgc cgtttacgtt ctgtaggcga gcttctccag 122761 aaccaattcc gtatcggttt aagccgtatg gagcgtgtgg ttcgtgagag aatgtcaatt 122821 caagatacga atacaattac gcctcagcag ctgatcaata ttcgtcctgt tattgcgtcc 122881 attaaagagt tctttggaag ctcacagctt tctcaattca tggatcagac gaacccgctt 122941 gctgaattaa cgcacaagcg tcgtctgtca gcattaggac cgggcggatt gacacgtgag 123001 cgtgccggaa tggaagtgcg tgacgttcac tactcccact atggccgtat gtgtccgatt 123061 gaaacgcctg agggcccgaa catcggtttg atcaactcac tatcatctta tgcaaaagta 123121 aaccgttttg gctttattga aacgccatat cgccgcgttg accctgaaac agggaaggta 123181 acgggcagaa tcgattactt aactgctgat gaagaggata actatgttgt cgctcaagcg 123241 aatgctcgtc ttgatgacga aggcgccttt attgatgaca gcatcgtagc tcgtttccgc 123301 ggggagaaca ccgttgtttc cagaaatcgt gtagactaca tggatgtatc gcctaagcag 123361 gttgtatctg ctgcgacagc atgtatcccg ttcttagaaa acgatgactc caaccgtgcc 123421 ctcatgggag cgaacatgca gcgtcaggct gtgcctttga tgcagccgga agcgccattt 123481 gttggaactg gtatggaata cgtatcagga aaagactctg gtgccgctgt tatttgtaaa 123541 caccctggta tcgttgaacg cgtagaagcc aaaaacgttt gggttcgccg ttatgaagaa 123601 gtagacggtc aaaaagtaaa aggaaacctg gataaataca gcctgctgaa atttgtccgc 123661 tctaaccaag gtacgtgcta caaccagcgt ccgatcgtaa gtgtcggcga tgaagtggta 123721 aaaggagaaa tccttgctga cggtccttct atggagcttg gtgaacttgc acttggccgt 123781 aacgtaatgg tcggcttcat gacgtgggat ggctacaact atgaggatgc catcatcatg 123841 agtgaacgcc tagtgaagga tgatgtttat acatctatcc acattgaaga atacgaatca 123901 gaagcacgtg atacgaaact tggacctgaa gaaatcactc gcgatattcc aaacgtcggt 123961 gaagatgcgc ttcgcaatct tgatgaccgc ggaatcatcc gtattggggc agaagtaaaa 124021 gacggagatc ttcttgttgg taaagtaacg cctaaaggcg taactgaact gactgccgaa 124081 gaacgccttc ttcacgccat ctttggcgag aaagcccgcg aggttcgtga tacttctctt 124141 cgtgtgcctc atggcggcgg cggaattatc catgacgtta aagtcttcaa ccgtgaagac 124201 ggagacgaac ttcctccagg tgttaaccag ttagtacgcg tatatatcgt tcagaaacgt 124261 aagatttctg aaggggataa aatggccggt cgtcacggta acaaaggtgt tatctctaag 124321 attcttcctg aagaggatat gccttacctt cctgacggca caccaattga tatcatgctt 124381 aacccgctgg gcgtaccatc acgtatgaac atcgggcagg tattggaact tcacatgggt 124441 atggccgctc gttaccttgg cattcacatt gcatctcctg tatttgacgg agcgcgagaa 124501 gaggatgtct gggaaacact tgaagaagcc ggcatgtctc gtgacgccaa aacagtgctt 124561 tacgacggac gtactggaga gccgtttgat aaccgtgtat ctgtcggtat catgtacatg 124621 atcaaactgg ctcacatggt tgacgataaa cttcatgcac gctctacagg cccttactca 124681 cttgttacgc agcagcctct tggcggtaaa gcgcaatttg gcggacagcg ttttggtgag 124741 atggaggttt gggcacttga agcttacggt gcggcttaca ctcttcaaga aattctgact 124801 gttaagtctg atgacgtggt tggacgtgtg aaaacatacg aagccatcgt taaaggcgac 124861 aatgttcctg aaccaggtgt tccggaatca ttcaaagtat taatcaaaga acttcaaagc 124921 ttaggtatgg atgtcaaaat cctttctggt gatgaagaag aaatagaaat gagagattta 124981 gaagacgaag aagatgcgaa acaagctgac ggcctggcat tatcaggtga tgaagagccg 125041 gaagaaacag catctgcaga cgttgaacgc gatgtagtaa caaaagaata atctctagtt 125101 ataaaggcaa gtgacatcgg ttaatccgaa gataaaaagg gaggtaggcc ccttgctaga 125161 tgtgaacaat tttgagtata tgaacatcgg tcttgcttca ccagataaaa tccgttcatg 125221 gtcttttggt gaagtgaaaa agcctgaaac gataaactat cgtacgttaa aacctgaaaa 125281 ggacggtcta ttctgcgaac gcattttcgg accgactaag gactgggaat gtcattgcgg 125341 gaagtacaag cgagttcgtt ataaaggcgt agtttgtgac cgctgcggag tcgaagtaac 125401 acgggctaaa gtccgtcgtg agagaatggg gcacattgaa ctggctgccc cagtttccca 125461 catttggtat ttcaaaggta ttccaagccg tatgggtctt gtgctggata tgtcacctcg 125521 tgctttagaa gaagtcattt actttgcttc ttacgttgta actgatccgg cgaatacacc 125581 gcttgaaaag aaacagcttc tgtctgagaa agaataccgt gcttatcttg ataaatacgg 125641 taataaattc caagcatcta tgggtgctga agcaattcat aaacttcttc aagatatcga 125701 tcttgtaaaa gaagttgata tgttaaaaga agagctgaaa acttcacaag gacaacgccg 125761 tactcgtgcg atcaaacgtc ttgaagtttt agaagccttc cgtaactcag gaaacaagcc 125821 ttcttggatg atccttgatg tgcttcctgt tattcctccg gagcttagac cgatggttca 125881 gctagatggc ggacgttttg cgacttctga tttgaatgac ctttatcgtc gtgtcatcaa 125941 ccgtaacaat cgtttgaaac gccttttgga ccttggtgcg cctagcatca tcgttcaaaa 126001 cgaaaagcgt atgcttcaag aggctgtcga tgccctaatt gacaacggcc gccgcggacg 126061 ccctgtaaca ggtcctggaa acagaccgtt aaaatctctt tctcacatgc tgaaagggaa 126121 gcaaggccgt ttccgtcaaa accttcttgg taaacgtgtc gattactccg gacgttctgt 126181 aatcgttgtt ggtcctcatt tgaaaatgta ccaatgcgga ttaccgaagg aaatggcact 126241 tgaacttttc aaacctttcg ttatgaaaga acttgttgaa aaaggtcttg ctcacaacat 126301 taagagtgcg aaacgcaaaa ttgagcgcgt acagcctgaa gtttgggatg tactagaatc 126361 agttattaag gagcatccgg tactgctgaa ccgtgcccct acacttcaca gattaggtat 126421 ccaggcgttt gaaccaacgc ttgttgaagg acgcgcaatc cgtcttcacc cgctcgtatg 126481 tacagcttac aacgctgact ttgacggtga ccaaatggcg gttcacgtac cattatctgc 126541 tgaagcacaa gctgaagcac gcatcttgat gcttgctgct caaaacatct tgaaccctaa 126601 agatggtaaa ccggttgtaa caccgtctca ggatatggta ctaggtaact attacctgac 126661 acttgagcgt gccggtgctg tcggtgaagg tatggtcttc aagaatacag acgaagcgct 126721 tcttgcttat caaaacggat atgttcacct tcatacgaga gtagctgttg cagctaactc 126781 acttaagaat gtgacattta ccgaagaaca gcgctcaaaa ttgttaatta caactgtcgg 126841 taagcttgtc ttcaatgaaa ttcttccgga atcattccct tacatgaatg aaccaacgaa 126901 gagcaacatt gaagagaaaa cacctgaccg tttcttctta gaaaaaggtg ctgatgttaa 126961 agctgttatc gcacagcagc caatcaatgc gccgtttaaa aaaggcattc tgggtaaaat 127021 catcgcggaa atctttaaac gattccatat tacggaaacg tctaaaatgc ttgaccgcat 127081 gaaaaaccta ggtttcaaat attcaactaa agctggtatt acagttgggg tttctgacat 127141 cgtcgtactc gatgataaac aagaaattct tgaggaagcg caaagcaaag ttgacaacgt 127201 tatgaagcaa ttccgccgcg gtcttatcac tgaagaagaa cgctatgaga gagtcatctc 127261 tatctggagt gctgcaaaag acgttatcca aggcaaactg atgaaatcac ttgatgaact 127321 caacccgatc tacatgatga gtgactctgg tgcccgtggt aacgcatcta actttacgca 127381 gcttgccgga atgcgcggcc tgatggccaa cccggctgga cgtatcattg agttgccgat 127441 caaatcaagt ttccgtgaag gtctgacagt attggagtac tttatctcca cacacggtgc 127501 gcgtaaaggt cttgccgata ccgctcttaa aactgctgac tcaggttacc ttacacgccg 127561 tctcgttgac gttgctcagg atgttatcat ccgtgaaact gattgcggaa ctgaccgagg 127621 cattcttgct aagcctctta aagaaggaac tgaaacaatt gagcgcttag aagaacgctt 127681 aatcggacgt tttgcaagaa aacaagtgaa gcaccctgaa acaggtgaag tgcttgtgaa 127741 tgaaaacgaa ctgatcgatg aagataaagc actggagatt gtcgaagccg gcattgaaga 127801 agtgtggatc cgttctgcct tcacatgtaa tacgcctcat ggtgtatgta aacgatgcta 127861 tggccgaaat cttgcaactg gctccgatgt tgaagtcggt gaagctgtcg gaatcattgc 127921 tgcccaatca atcggtgagc ctggtacaca gttaacaatg cgtacattcc atacaggcgg 127981 ggttgccgga gacgatatca cacagggtct tccgcgtatc caagagcttt tcgaagcgcg 128041 taatccgaaa ggtcaggcaa caattacaga aatcgacggt acagtcgttg agatcaatga 128101 agttcgtgat aagcaacagg aaattgtggt tcaaggcgca gtggaaacac gttcttatac 128161 ggcaccttac aactcccgcc tgaaagtagc ggaaggagat aaaattactc gaggccaagt 128221 actgacagaa ggttcaatcg atccgaaaga acttcttaaa gtgactgacc tgacgactgt 128281 tcaagagtat cttctccatg aggttcaaaa ggtttaccgt atgcagggtg ttgaaatcgg 128341 tgataaacac gtagaagtaa tggttcgcca gatgcttcgc aaagtacgcg tgattgatgc 128401 cggtgacact gatgtgcttc caggtacatt gcttgatatt caccaattta ctgaagcgaa 128461 caaaaaggta ttgcttgaag gcaaccgacc agctacaggc cgtcctgtct tactcggtat 128521 tacaaaagca tctcttgaaa ctgattcatt cttatctgct gcttccttcc aggaaacaac 128581 acgtgtcctt acagatgcag cgatcaaagg taagcgtgac gagcttctcg gcttgaaaga 128641 gaatgttatc atcggtaagc ttgttccagc aggtacagga atgatgaaat accgtaaagt 128701 aaaaccagta tcaaatgttc agccgactga cgatatggtc ccggttgaat aactgattta 128761 actctgctga aagactgcaa aaacagtctt tcagcagata tatttatgaa aaagtcactc 128821 tatgagaaga acgaatctaa aaaatgtcat accttgttga cattcgtctc ctagaatgat 128881 aatataacca aggtgctcga aataaacctg ttactttgga ggatatgttt atgtcttatg 128941 ataaagtatc acaggccaaa tcaattatta ttggtacgaa gcaaacagtg aaagctctaa 129001 agcgaggttc agtaaaggaa gtagtcgttg caaaagacgc agatccgata ctcacgtcaa 129061 gtgttgtttc acttgctgaa gatcaaggta tctctgtctc aatggttgaa tccatgaaaa 129121 agctcggcaa agcctgcgga attgaggtag gagcagccgc tgttgccatt attttataac 129181 gtacttttgt ttttgcgtaa gattccatct tgtgtaaaga cattgttttt tgccttttga 129241 tgaaccacct gggtatgtgg gttataaaac gtaatgaagg gaggaaaaat tcatgcctac 129301 aattaatcag ctaattcgca aaggacgcgt gagtaaagta gaaaactcaa agtctcctgc 129361 acttaacaaa ggatacaaca gctttaaaaa agagcacact aacgtatctt ctccacaaaa 129421 acgcggggta tgtactcgtg ttggtacaat gacaccgaaa aaaccgaact cagcacttcg 129481 taaatatgct cgtgttcgtt tgactaacgg aatcgaggtt actgcttaca ttcctggtat 129541 cggtcacaac ctgcaagagc acagtgttgt acttatccgc ggcggacgtg taaaagactt 129601 accaggggta cgttaccaca tcgttcgtgg tgcgcttgat actgctggag ttgaaaaccg 129661 tgcacaaggc cgttctaaat acggtacgaa aaaacctaaa gcaaaataat atacgaaaat 129721 acgcataatt gatgaaggga ggatattcag atgccacgta aaggtcctgt agcaaaaaga 129781 gatgttttac ctgatccgat ttacaactct aagcttgtat ctcgtttaat caacaaaatg 129841 atgatcgatg gtaaaaaagg taagtctcaa acgatcctat acaagtcatt cgatatcatt 129901 aaagaacgta ctggcaatga tgcaatggag gttttcgaac aagcattgaa aaacatcatg 129961 cctgtacttg aagtaaaagc acgccgtgta ggtggtgcga actaccaagt tcctgtagaa 130021 gttcgtcctg aacgtcgtac gactcttgga cttcgctggt tagttaacta cgctcgtctt 130081 cgtggagaaa aaacgatgga agagcgttta gctaacgaaa tccttgacgc agctaacaac 130141 actggtgctg ctgttaagaa acgtgaagac actcataaga tggctgaagc aaacaaagca 130201 tttgctcact atcgctggta ggatttatag attaacaaaa cacaatttcc taataaggaa 130261 ggagaaatta cccaatggca agagagttct ccttagaaaa aactcgtaat atcggtatca 130321 tggctcacat cgatgccggt aaaacgacta ctacagaacg tatcttgttc tatactggtc 130381 gtatccacaa aattggtgaa actcatgaag gagcttcaca aatggactgg atggagcagg 130441 aacaagaacg tggtatcaca atcacttccg ctgcgactac tgcacagtgg aaaggatacc 130501 gcgtaaacat catcgatact ccaggacacg tagacttcac agttgaagtt gaacgttctc 130561 ttcgtgtact tgatggtgct gttgctgtac ttgacgcgca atcaggcgtt gagcctcaaa 130621 cagaaactgt ttggcgtcag gcaacaactt atggagtacc gcgtatcgtt tttgttaaca 130681 aaatggacaa aatcggtgca gacttccttt actctgtagg aactttaaga gaccgtcttc 130741 aagcaaacgc tcatgcaatt caattgccga tcggtgctga agataacttc gaaggtatca 130801 ttgaccttgt agaaaacgtt gcgtatttct acgaagatga cctcggaact cgttctgatg 130861 caaaagaaat ccctgaagag tacaaagagc aagctgaaga gcttcgcaac agccttattg 130921 aagctgtatg tgagcttgat gaagagctta tggataagta ccttgagggt gaagaaatca 130981 caattgacga gttaaaagca ggaattcgta aaggtacatt aaatgttgaa ttctaccctg 131041 ttcttgttgg ttctgccttc aaaaacaaag gtgttcaact agtacttgat gctgttcttg 131101 actaccttcc tgcaccaact gacgttgctg caatcaaagg tacacgtcct gatacaaatg 131161 aagagattga gcgtcattct tctgacgaag agccattctc tgcattagca tttaaagtta 131221 tgactgaccc ttacgttggt aagttgacgt tcttccgtgt gtactctgga acacttgatt 131281 ctggttcata cgtgaaaaac tctactaaag gcaaacgtga gcgtgttgga cgtattcttc 131341 aaatgcacgc taacagccgt gaagaaatct ctactgtata cgcaggggat atcgcagctg 131401 ctgtaggtct aaaagataca actactggag atactctatg tgatgagaag gatcttgtta 131461 tccttgagtc aatggaattc ccagaaccag ttatcgacgt tgctattgag cctaaatcaa 131521 aagctgacca agataaaatg ggtatcgctt tagcgaaact tgctgaagaa gatcctacat 131581 tccgtactca aacaaaccca gaaactggcc aaacgatcat ctctggtatg ggtgaacttc 131641 accttgatat cattgttgac cgtatgaaac gcgaatttaa agtagaagcc aatgttggtg 131701 ctcctcaagt tgcgtaccgt gaaacattcc gtaccggtgc aaaagttgaa ggtaaattcg 131761 tacgtcagtc tggtggacgc ggtcagttcg gacacgtttg gatcgaattc gaaccaaacg 131821 aagaaggcgc tggctttgaa tttgaaaatg cgattgtcgg tggggtcgtt cctcgtgaat 131881 acatcccagc tgttcaagca ggtctggaag atgcactcga aaatggtgta ctagcaggct 131941 tcccgcttat cgacattaaa gctaaacttt tcgacggttc ttaccatgat gttgactcaa 132001 acgaaatggc atttaaagtc gctgcttcta tggcattgaa aaatgcagtc agcaaatgta 132061 acccagttct tcttgaacca atcatgaaag tggaagtggt tattccagaa gaatatatgg 132121 gagatatcat gggtgatatc acttcacgtc gcggacgcgt agaaggtatg gaagcacgcg 132181 gtaacgctca agttgttcgt gctatggttc ctcttgctga aatgttcggt tacgctactg 132241 cacttcgttc taatacgcaa ggtcgcggta cgttcactat gcacatggat cactacgaag 132301 aagtgccgaa gagcgtcgca gaagaaatta tcaaaaaaaa taaaggcgaa taattgattt 132361 tgccgcttaa ctcaagtata actactattg taagatgagg aagtgaaagc tttctttcac 132421 ttcctatcac tctatacatt actaattaaa agctcttaag gaggatttta gaatggctaa 132481 agaaaaattc gaccgttcca aatcacatgc caatattggt acaattggac acgttgacca 132541 tggtaaaaca actttaactg ctgctatcac aacagtactt cataagaaat ctggtaaagg 132601 tacagctatg gcgtacgatc aaattgatgg tgctccagaa gaacgcgagc gcggtatcac 132661 aatctctact gcacacgttg agtacgaaac tgaaactcgt cactatgcac acgttgactg 132721 cccaggacac gctgactatg ttaaaaacat gatcactggt gctgcgcaaa tggacggagc 132781 tatccttgta gtatctgctg ctgatggccc aatgccacaa actcgtgagc acatccttct 132841 ttctaaaaac gttggtgtac catacatcgt tgtattctta aacaaatgcg acatggtaga 132901 cgacgaagag cttcttgaac tagttgaaat ggaagttcgc gatcttctta gcgaatacga 132961 cttccctggt gatgatgtac cagttgttaa aggttctgct cttaaagctc ttgaaggaga 133021 cgctgagtgg gaagctaaaa tcttcgaact tatggatgcg gttgatgagt acatcccaac 133081 tccagaacgc gacactgaaa aaccattcat gatgccagtt gaggacgtat tctcaatcac 133141 tggtcgtggt acagttgcta ctggccgtgt agaacgcgga caagttaaag tcggtgacga 133201 agttgaaatc atcggtcttc aagaagagaa caagaaaaca actgttacag gtgttgaaat 133261 gttccgtaag cttcttgatt acgctgaagc tggtgacaac attggtgccc ttcttcgcgg 133321 tgtatctcgt gaagaaatcc aacgtggtca agtacttgct aaaccaggta caatcactcc 133381 acacagcaaa ttcaaagctg aagtttacgt tctttctaaa gaagagggtg gacgtcatac 133441 tccattcttc tctaactacc gtcctcagtt ctacttccgt acaactgacg taactggtat 133501 catccatctt ccagaaggcg tagaaatggt tatgcctgga gataacactg aaatgaacgt 133561 tgaacttatt tctacaatcg ctatcgaaga aggaactcgt ttctctattc gtgaaggcgg 133621 acgtactgtt ggttcaggcg ttgtttctac aatcactgag taatagtatg gttttaaacg 133681 agacccctgt gggtctcgtt ttttgtttgc ttatcttttt cttgtataat aggatctatc 133741 atattcgagg ggttaatatt tatgattcct gaaaagaaat caatcgcaat catgaaagaa 133801 ctaagcattg gaaatacaaa gcaaatgctg atgattaatg gagttgacgt gaaaaatcca 133861 ttgctgcttt ttttacatgg cgggccggga acgccgcaaa tcggatatgt tagacattat 133921 caaaaagagc tggaacagta ttttacagta gttcattggg atcagagagg atcggggctt 133981 tcttattcta agcgaatttc gcatcactct atgacaataa atcacttcat taaagataca 134041 atccaagtca ctcaatggct tttagctcat ttttcaaaat caaaacttta cctagccggt 134101 cattcttggg gatcaatact ggcgcttcat gtgctgcagc agcgtcctga tttattttac 134161 acgtattatg gaatcagcca ggttgttaac ccgcaagatg aagaatcaac tgcttatcaa 134221 catattcgtg aaatttccga atcaaaaaaa gccagcatat tatctttcct tacacgtttc 134281 attggtgctc cgccttggaa gcaggatatc cagcacctta tctatcggtt ttgtgttgag 134341 ctaaccaggg gaggattcac tcaccgtcat cgtcaatctc tcgctgtatt atttcaaatg 134401 cttactggca atgagtatgg agtgcggaac atgcacagct tccttaatgg attgcgcttc 134461 agtaaaaaac atttaactga tgagttgtac cggtttaatg cttttacatc agttccttct 134521 attaaagtac cgtgtgtttt catttcaggg aaacatgact taattgttcc tgcagaaata 134581 tcgaaacagt attatcaaga acttgaggca cctgaaaagc gctggtttca atttgagaat 134641 tcagctcaca ccccgcatat tgaggagcca tcattattcg cgaacacatt aagtcggcat 134701 gcacgacacc atttatgata gatccttgat aaataagaaa aacccctgta taataaaaaa 134761 agtgtgcaaa tcatgcatat tttaaataag tcttgcaaca tgcgcctatt ttctgtataa 134821 tggtgtatgt tggtctttga ctgcgatgaa gtgagaggtt gctgacacac ccggccgctt 134881 tgccatggca aggtgttcag gtttttctca cggagaactg tctaacgtga tgtaggcgaa 134941 aaggagggaa aataatggca aaacaaaaaa ttcgtattcg tttgaaagca tatgatcata 135001 gaatccttga tcaatctgca gagaagattg ttgaaacggc aaaacgttct ggtgccagcg 135061 tatctggtcc gattccgttg ccaactgaaa aatcagttta cacaatcctt cgtgcggtgc 135121 acaaatacaa agattctcgt gagcaatttg aaatgcgtac acataaacgt ttaatcgaca 135181 ttgtgaaccc aacaccacaa actgttgatg ctcttatgcg attagactta ccatctggtg 135241 tcgatatcga aattaaactt taattctaaa atatagaatg atcttaatag gaggtgtgac 135301 gaatgaccaa aggaatctta ggaagaaaaa ttggtatgac gcaagtattc gctgagaatg 135361 gtgatcttat tccggtaact gttatcgagg ctgctccaaa cgttgttctt caaaagaaaa 135421 cagctgaaaa cgacggttac gaagcaatcc agcttggttt tgacgacaag cgtgaaaagc 135481 tttctaacaa acctgaaaaa gggcacgttg caaaagcgga aactgctcct aagcgcttcg 135541 ttaaagaatt acgcggagtg gaaatggatg cgtatgaagt tggtcaggaa gtcaaggttg 135601 aaattttctc tgctggagaa atcgtagatg taacaggagt atctaaaggt aaaggtttcc 135661 aaggtgcgat caagcgccac ggacaatctc gcggacctat gtctcacggt tcacgctacc 135721 accgtcgtcc tggttcaatg ggacctgtag atcctaaccg tgtattcaaa ggtaaattat 135781 tacctggacg tatgggcgga gagcaaatca ctgttcaaaa ccttgaaatc gtaaaagttg 135841 atgcagaacg caatcttctt ttgatcaaag gtaacgtacc tggtgcgaag aaatctttaa 135901 tcactgttaa aagtgctgtt aaatctaaat aattctctta ggaaaggagg aaattgatta 135961 tgccaaaagt agcattatac aaccaaaacg gttctactgc tggtgacatc gaattaaacg 136021 cttctgtatt tggtatcgaa ccaaatgaga gtgttgtatt cgacgctatt cttatgcaaa 136081 gagcttcctt acgtcaagga actcacaaag taaaaaatcg ttctgaagta cgcggcggag 136141 gtcgtaaacc atggcgtcaa aaaggtactg gacgtgcccg tcaaggttca atccgttcac 136201 cgcaatggcg cggaggtggt gtcgtattcg gcccaacacc acgcagctat tcttataaat 136261 tacctaaaaa agttcgccgc ttggcaatca aatcagtatt gtcttctaaa gtgatcgaca 136321 acaacatcat cgttcttgaa gatcttactc ttgatacggc taaaacaaaa gaaatggcag 136381 ctatccttaa aggattatct gttgagaaaa aagctttaat cgtaactgcg gatgcaaacg 136441 aagcagtagc attatctgct cgtaacattc ctggagttac tgttgttgaa gctaacggaa 136501 tcaacgtttt agacgttgtc aaccacgaga agcttctgat tacaaaagca gcggttgaaa 136561 aagtagagga ggtgcttgca taatgaaaga tcctcgtgat gttctaaagc gccccgtcat 136621 tactgaacgt tctgccgatt taatgactga aaaaaaatat acttttgaag ttgatgtaag 136681 agctaacaaa acagaagtga aagacgcggt tgaaagcatc tttggagtga aagttgacaa 136741 agtcaacatc atgaactaca aaggcaaatc aaaacgtgtt ggacgctaca ctggtatgac 136801 tagccgtcgc agaaaagcga tcgtaaaact tactgcagac agcaaagaaa tcgaaatttt 136861 tgaagcttaa ttatctgtaa aaagaaggag ggaaattcaa aatggcgatt aaaaagtata 136921 aaccgacctc taatggacgt cgtggcatga caacttcaga ttttgctgaa atcacgactg 136981 acaagccgga aaaatccttg cttgctcccc ttcacaaaaa aggcggacgt aacaaccaag 137041 gtaaattgac tgtacgtcac caaggtggcg gacataaacg ccaataccgt gttatcgact 137101 tcaaacgcga taaagatggt atacctggac gcgttgctac agttgaatac gatccaaacc 137161 gttcagctaa catcgctcta atcaactatg cagacggaga aaaacgttac attcttgctc 137221 ctaaaggaat tcaagtaggt actgaaatca tgtcaggtcc tgaagctgac attaaagtag 137281 gtaatgcact tccacttatc aacatccctg ttggtacagt tgtgcataac attgaattaa 137341 aacctggtaa aggcggacag cttgtacgtt cagctggtac atctgctcag gttcttggta 137401 aagaaggtaa atacgttctt gtacgtctta actctggtga agttcgcatg atcctttctg 137461 cttgccgtgc ttctatcggt caagtaggta acgaacagca cgaacttatc aacattggta 137521 aagctggacg ttctcgctgg aaaggcatcc gtcctacagt tcgtggttct gtaatgaacc 137581 ctaacgatca cccacacggt ggtggtgaag gacgtgcgcc aatcggacgt aaatcaccaa 137641 tgtctccatg gggcaaacca actcttggat tcaagactcg taagaaaaag aacaaatccg 137701 ataaatttat cgtacgtcgt cgtaaaaata aataacgggg ttgtctacgg ttcttttcgg 137761 accgtagtgc aatcacgaag ggaggttcca aaatggctcg cagcttaaaa aaaggaccat 137821 ttgtcgatgg acacttgatg actaaaatcg agaaattaaa tgaaacagac aagaaacaag 137881 tcgtaaaaac ttggtctcgt cgttctacta ttttcccaca gtttattggt cacacaatcg 137941 cagtctatga cggacgtaaa cacgtgcctg tattcatctc tgaagatatg gtagggcaca 138001 agttgggtga attcgctcca actcgtacgt acaaaggtca tgctagtgat gacaaaaaaa 138061 caagacgcta agagaggagg cttttaaatg caagctaaag ctgttgcaag aacagtccgt 138121 attgctcctc gtaaagcacg tctagtaatg gacctgattc gaggcaagca agtaggtgag 138181 gcagtatcaa tcttgaacct tacaccaaga gctgcttctc caattatcga gaaagtatta 138241 aaatccgcta ttgcaaatgc tgagcataac tatgaaatgg acgctaacaa cctggttatt 138301 tctcaagcat tcgttgacga aggccctacg ttaaaaagat tccgcccacg tgctatggga 138361 cgtgcgagcc aaatcaacaa acgtacgagc cacattacaa tcgttgtatc agaaaagaag 138421 gagggataag tagtgggtca aaaggtaaat ccagtcggtc ttcgtatcgg agtcattcgt 138481 gattgggaat ctaagtggta cgctggtaaa gattacgctg acttcctgca cgaagattta 138541 aaaattcgtg aatacattag caaacgcctt tctgacgctt ctgtttctaa agtagaaatt 138601 gagcgtgcag caaaccgcgt taacattacg atccacacag ctaagcctgg tatggttatc 138661 ggtaaaggcg gttctgaagt cgaagcactt cgcaaagccc ttaacagcct tactggcaag 138721 cgtgtacaca ttaacattct tgaaatcaaa agagcagatc ttgatgcaca gctagttgct 138781 gacaacatcg ctcgtcaatt agaaaaccgt gtttctttcc gccgtgcgca gaaacaacaa 138841 atccaacgta ctatgcgtgc tggagcacaa ggtgtgaaaa caatggtttc tggtcgtctt 138901 ggcggtgcag atatcgctcg ttctgaatac tacagtgaag gaactgttcc attgcacaca 138961 ttacgtgcgg acattgacta tgcaacatct gaagctgata ctacttacgg taagcttggt 139021 gtaaaagtct ggatctatcg tggagaggtt cttcctacta agaagaaaaa tgaggaagga 139081 ggaaaataat atgttattac caaaacgcgt taaatatcgc agagagcatc gcggaaaaat 139141 gcgtggccgt gcgaaaggcg gtactgaagt acatttcgga gaattcggta tccaagctct 139201 agaagcttct tggattacta accgtcaaat cgaagctgca cgtattgcga tgactcgtta 139261 catgaaacgt ggcggtaaag tttggatcaa aattttccct tctaaacctt acactgctaa 139321 accacttgag gtacgtatgg gatccggtaa aggggctcca gaaggttggg tagctgttgt 139381 aaaaccgggc aaagttttat ttgaaatttc tggtgtgtct gaagaggttg ctcgtgaagc 139441 gcttcgcctt gcatctcaca aattgccaat taaaacgaag ttcgtaaaac gtgaagaaat 139501 tggtggtgaa tcaaatgaaa gctaatgaaa ttcgtgacct taccactgct gaaattgaac 139561 aaaaagtaaa gtctcttaaa gaagaacttt tcaatcttcg ctttcaatta gcgacaggac 139621 aacttgaaaa tactgctcgc attcgtgaag tgcgcaaagc tatcgcgcgc atgaaaactg 139681 tgattcgtga aagagaaatt gctgctaata aataatcact gaggggaggt cgtgagcatg 139741 agcgaacgta accaacgcaa agtttaccaa ggccgtgttg tttctgacaa aatggataaa 139801 accattactg ttgttgttga gacatacaaa aaacatacac tttacggtaa acgcgtaaaa 139861 tactcaaaaa aattcaaagc acatgatgaa aataatcaag ctaaaatcgg tgacatcgtt 139921 aagatcatgg aaactcgtcc attgtctgca actaagcgtt tccgtctagt tgaagttgtc 139981 gaagaagctg ttattatcta ataaagttcg gaattctttt tccgaaggga ggtaacaaat 140041 aatgattcaa caagagactc gtttaaaagt agctgacaac tctggcgcac gtgaagtact 140101 tactattaaa gttcttggtg gttctggacg taaaacagct aacattggtg atgtaattgt 140161 ttgcacggtt aaacaagcaa caccaggagg cgttgtcaaa aaaggtgaag tcgtaaaagc 140221 tgttatcgtt cgcactaaaa gcggagcgcg cagaagtgac ggttcataca tcagcttcga 140281 tgagaatgca tgtgttatca tccgtgacga caagagccca cgcggaactc gtatcttcgg 140341 accagttgct cgtgaattgc gtgaaaacaa ctttatgaaa attgtttctc tagctccaga 140401 agttatctaa ttgaaataaa tgccttactc aaggaggtgc gatcaggatg catgtaaaaa 140461 aaggcgataa agttatggtt atctctggta aagataaagg caaacaagga acaatccttg 140521 ctgctttccc taaaaaggac cgcgttttag ttgaaggtgt taacatggta aagaaacact 140581 ctaaaccaac tcaagctaac cctcaaggcg gtatttctaa tcaagaggcg ccaattcatg 140641 tatcaaacgt tatgccgctc gatcctaaaa caggtgaagt gactcgcgta ggatacaaag 140701 tggaagatgg caaaaaagtt cgtgtagcaa aaaaatctgg gcaagttcta gataaatagt 140761 attaaaagga agggaggtct atctcatgaa ccgccttaaa gaaaagtaca ataaagaaat 140821 tgcacctgct ttaatgacta agttcaacta tgattcagtc atgcaagtgc ctaaaatcga 140881 aaaaatcgta atcaacatgg gtgttggtga cgctgttcaa aacgccaaag caatcgacag 140941 tgctgttgag gaattaacgt ttatcgcagg tcaaaaacct gtcgttactc gtgcgaagaa 141001 atcaattgct ggattccgtc ttcgtgaggg aatgcctatc ggtgcgaaag taactcttcg 141061 cggagagcgc atgtatgatt tccttgataa acttatttct gtatctttac cgcgtgtacg 141121 tgacttccgc ggggtttcta aaaaatcttt cgacggtcgc ggtaactaca cacttggtat 141181 caaagaacag ttaatcttcc ctgaaattga ctacgataaa gtaacaaagg ttcgcggaat 141241 ggacatcgtt atcgtaacaa ctgctaatac tgacgaagaa gctcgtgagc tattaactca 141301 agtaggtatg ccgttccaga aataatcaat gaaagggagg cgaaatcgtg gctaaaaagt 141361 ctatgattgc gaaacaacaa cgtacaccaa agtttaaagt acaagagtac acacgctgtg 141421 aacgctgcgg acgtccgcat tcagtcattc gtaaatttaa actttgccgt atttgtttcc 141481 gtgagcttgc atataaagga caaattcctg gcgtgaaaaa agccagctgg taatccccaa 141541 gaaagggaag gaggtaatta tataatggtt atgacagatc caattgcaga tatgctaact 141601 cgtattcgca atgcaaacat ggtacgtcat gagaagcttg aaattcctgc ttctaaattg 141661 aaaagagaaa ttgctgaaat tttaaagcgt gaaggtttca ttcgtgacgt tgagttcgta 141721 gaagacagca aacaaggtat tatccgcgtt ttcttgaaat acggacaaaa caacgagcgc 141781 gttatcactg gtcttaaaag aatcagcaag cctggtttgc gtgtttatgc taaatctaat 141841 gaagtacccc gcgtacttaa cggtcttgga atcgcgatta tttctacatc acaaggtgtt 141901 ttaacggaca aagaagcccg tgcaaaacaa gctggtggag aagttctagc atacgtttgg 141961 taagaagttt aacatgaatg gaggtgtttg gtatgtctcg tgtaggtaag aagctacttg 142021 agattccttc tgatgttaca gtaacgttaa atgataacaa cactgtagct gtgaaaggac 142081 caaaaggaga attaactcgt acgtttcacc ctgatatgga gattaaagta gaggacaatg 142141 tgcttacagt cgctcgtcct tctgatcaaa aagagcaccg tgccctgcat ggtacgactc 142201 gcagtctgct tggcaacatg gttgaaggtg tatctaaagg atttgaaaga ggtttggaat 142261 tagtcggtgt cggttaccgt gcttctaaat ccggaaataa acttgtttta aacgttggat 142321 actctcatcc tgttgagatc gttcctgaag aaggcatcga aatcgaagtt ccttctcaaa 142381 caaaagtagt tgtaaaaggt acagacaaag aacgcgtagg agctattgct gctaacatcc 142441 gcgctgtacg ttctccagag ccttacaaag gtaaaggaat ccgctacgaa ggtgaagttg 142501 ttcgccgtaa agaaggtaaa tctgctaagt aagatcgctt aaagtgaaga aaggagtgac 142561 ctagatgatt acgaaaacta gcaaaaatgc tgctcgtctt aaaagacacg ctcgtgttcg 142621 cgctaaactt tccggtactg ctgaaagacc gcgcctgaac gttttccgtt ctaacaagca 142681 catttacgct caaatcatcg atgatgtaaa tggtgtaaca cttgctagtg catctactct 142741 cgataaagac ttgaacgttg aaagcactgg agatacttct gctgctacta aagttggaga 142801 attagttgca aaacgcgctg ctgaaaaagg catttctgac gtagtatttg accgtggcgg 142861 atacttatac catggacgtg taaaagcttt ggctgatgcc gctcgtgaag ctggacttaa 142921 attttaataa aagaaggagg gacacatgat tatgcgtcgt attgacccaa gcaaattaga 142981 gttagaagaa cgcttagtta cggttaaccg cgtagcgaaa gttgttaaag gtggtcgtcg 143041 tttccgcttc gcagctctag tcgttgtcgg tgacaaaaac ggacacgtag gattcggtac 143101 tggtaaagca caagaagtac cagaagcgat tcgcaaagct gttgaagatg cgaaaaagaa 143161 tttgattgaa gtaccaatgg ttggaactac aattccacac gaaatcatcg gacgtttcgg 143221 tgcaggtaac atcttgttaa aacctgcttc tgaaggtact ggagttatcg ctggaggccc 143281 tgtacgtgcg gtacttgagc tagctggtgt agctgatatc ctttctaagt ctttaggttc 143341 taacacaccg atcaacatga ttcgtgcaac acttcaaggt ttaagtgaac ttaaacgtgc 143401 tgaagacgtt gcgaagcttc gtggaaaatc tgtagaagaa ctgttaggat aaggagggaa 143461 cattaatggc taaattagaa attaccctca aacgaagtgt aatcggtcgc ccggaagacc 143521 aacgcgttac tgtaagaaca cttggtttaa agaaaacaaa ccaaactgtt gttcatgaag 143581 acaacgctgc gatccgtggt atgattaata aagtatctca tttagtttct gttaaagaac 143641 aataaaaata tttgatcgga taaggaggtg tcctaatgaa acttcatgaa ttaaaacctt 143701 cagaaggttc acgcaaaacg cgtaatcgcg taggtcgtgg tattggttct ggcaacggta 143761 aaacagctgg taaaggtcac aaaggtcaaa acgctcgttc tggcggcggt gtacgccctg 143821 gattcgaggg gggacaaatg cctttattcc aacgtcttcc taaacgtggt ttcactaaca 143881 tcaaccgcaa ggaatacgct gtagtcaacc tagacaaatt gaacggtttt gcagaaggaa 143941 cggaagtcac tcctgaactt cttctagaga ctggtgttat tagcaaactt aatgcaggag 144001 taaagattct tggcaacggt aaattagaga aaaaattaac tgtaaaagcc aataaattct 144061 ctgcttctgc gaaagaagct gttgaagctg ctggcggtac agctgaggtg atctaacttg 144121 tttaaaacaa tctccaactt tatgcgtgtg agtgatatca ggaataaaat catattcact 144181 ttactcatgc ttatcgtctt tcgcataggt gcgtttattc ctgtgcctta cgttaacgct 144241 gaagcgttac aggcacagtc tcaaatgggt gtttttgatc tccttaatac atttggcggc 144301 ggtgcgcttt accaattttc cattttcgca atgggaatta ctccttatat cacggcttcg 144361 atcatcattc agctgcttca gatggatgtg gtaccgaagt ttaccgagtg gtctaagcaa 144421 ggtgaagttg gccgccgtaa attagctcag ttcacaaggt actttacgat tgtgcttggt 144481 ttcatccaag cgttaggtat gtcatatgga ttcaacaatc tggcaaacgg tatgctgatc 144541 gaaaaatccg gtgtatcgac atatcttatc attgctttag tgctcactgg cggaactgcc 144601 tttttaatgt ggcttgggga acaaattact tctcatggag taggcaacgg aatatcgatc 144661 attatcttcg cggggattgt gtctagtatt ccaaaaacaa ttgggcaaat atatgagact 144721 caatttgtcg gcagcaacga tcagttgttt attcatattg tgaaagtcgc acttcttgtg 144781 attgcgattt tagcagttat tgttggagtt attttcattc agcaagccgt acggaaaatt 144841 gcgattcaat atgctaaagg cacaggtcgt tcacctgctg gcggaggtca gtctacacac 144901 cttccattga aagtgaatcc tgcaggggtt attccggtaa tctttgcggt tgcgtttttg 144961 ataacgccgc ggacgatcgc gtcattcttt ggaacaaacg atgtgacaaa gtggattcaa 145021 aacaactttg ataatacgca tccggtgggt atggcgatat atgttgcgtt gattattgcc 145081 tttacgtact tttatgcttt tgtacaggta aaccctgaac aaatggctga taaccttaaa 145141 aaacagggtg gctatatccc gggggttcgt ccagggaaaa tgactcaaga tagaattacg 145201 agcattttgt atcgacttac gtttgtgggt tctatattct tagccgtgat ttccattctt 145261 cctatctttt tcattcaatt cgctggattg cctcaaagtg cacaaattgg cggaacatct 145321 ttgttaattg ttgtcggggt agccttggag acaatgaaac aactagaaag ccagttggtg 145381 aaacgaaact accgtggatt tatgaaaaac tagaggaaat ggatttatcc attccctctt 145441 aataaagaga ggacggggga aatccgaatg aacttagtct taatggggct tcctggtgcc 145501 ggtaaaggca cacagggcga acgaattgtt gaggattatg ggattcctca tatctcaaca 145561 ggagatatgt tccgtgctgc tatgaaagaa gaaacaccac tcggactcga agcaaaatct 145621 tatattgata agggagagct cgtacctgac gaagtcacaa tcggaattgt aaaagagaga 145681 cttggcaaag atgattgtga aagaggtttt cttctggacg gatttccgcg aacagtcgct 145741 caagccgaag ctcttgaaga aattcttgag gaatacggca agccgattga ttatgtcatt 145801 aacattgaag tcgacaaaga tgttctgatg gaacgtctga ctggacgcag aatttgcagt 145861 gtttgcggca caacctatca tttagtcttt aatccgccga aaacgccggg tatttgtgat 145921 aaagacggag gcgaactcta tcaacgggca gatgataatg aggaaacagt ctctaaacgg 145981 cttgaggtaa acatgaagca aactcagcct ttactcgatt tctattcaga gaaaggttat 146041 cttgcaaacg tgaatggcca gcaggacatt caagacgttt atgcagatgt gaaggatctt 146101 cttggaggat taaaaaaatg attatctgta aaaccccacg tgaacttggt atcatgcggg 146161 aagcagggcg aatcgtggct ttaactcatg aagagttaaa aaagcacatt aaaccaggaa 146221 tctcgacaaa agaattggat caaattgccg aacgttttat taagaagcag ggtgcaatcc 146281 catcttttaa ggggtataat gggtttcgcg ggagcatttg cgtatcagtt aatgaagaac 146341 tcgttcacgg catacctggc agcagggtgc tgaaggacgg tgacatcatc agtattgata 146401 tcggtgctaa attaaatggt tatcatggtg actctgcatg gacatatccg gtaggaaaca 146461 tcagcgatga tgacaaaaaa cttctggaag tgacagagga gtctttatat aaaggcttgc 146521 aggaagcaaa accaggtgaa cgtttgtcga atatttccca cgcaatacaa acgtatgtcg 146581 aaaatgagca gttttcagtt gttagggagt atgtcggaca tggtgttggt caagacttgc 146641 atgaggaccc gcaaattcct cattacggtc cgcccaacaa aggaccacgg cttaaacctg 146701 gcatggttct cgctattgaa cctatggtga acgctggcag ccgctacgtg aaaacattgg 146761 ctgataactg gacggttgta acggtagatg ggaaaaagtg tgctcatttt gaacatacga 146821 ttgcgattac ggaaacgggt tttgatatac tgacgagagt ctagatgatg aaaataattc 146881 cgaagacaga tgtttttcaa gcttgatagg gcagaaagct tgggtgaaca ttggcaagac 146941 cgaattcatc ttgcttcttg tcgttggaat tttaaccatc atcaatgtac taacagcaga 147001 cggagaaaag cgtacatttc attctcctaa gaaaaagaat atcaatcatt taacccttta 147061 tgattgcgta tctccggaag ttcagaacag tataaacgaa acagggcgtg tgacaaactt 147121 cttttgaaat ttgtcagaaa gcaagttact gatttgaaga agggagaaca cttgaatggc 147181 gaaagacgat gtaattgaag tggaaggtac tatagtcgaa acactgccaa acgcgatgtt 147241 caaagttgaa cttgaaaatg gccacactgt tttggctcat gtatctggta aaatccgcat 147301 gcacttcatt cgcattttac ctggagacaa agttacggta gaattatctc catatgactt 147361 aactcgtggc aggattacgt accgttacaa ataaagcact ccggaaactg aaggaggttg 147421 gaaacacatg aaagtgagac catcagttaa accaatctgc gaaaaatgta aagttattcg 147481 cagaaaagga aaagtaatgg tgatctgtga aaatccaaag cataaacaaa aacaaggata 147541 atttataagg aggtgcccag agaatggctc gtattgctgg tgtagatatc ccacgtgaca 147601 aacgtgttgt tatttcttta acatacatct tcggaattgg ccgcacaacg gctcagcaag 147661 ttttaaaaga agctggagtt tcagaagata ctcgtgtgcg cgatcttact gaagaagaac 147721 ttggtaaaat ccgtgatatt attgacaaac tgaaagtaga aggtgacctt cgccgtgaag 147781 tttctcttaa tatcaaacgt ctgatcgaaa tcggaagcta ccgcggaatc cgtcatcgca 147841 gaggattacc tgttcgcgga caaaactcta aaaacaacgc gcgtactcgt aaaggtccgc 147901 gtcgtactgt agctaacaag aaaaaataag taagggaggt tcttaaacaa tggctgctgc 147961 tcgtaaatct aacacgcgta aacgtcgcgt gaaaaagaat attgagtctg gaattgctca 148021 tattcgttca actttcaata acacgatcgt tacgatcact gacactcatg gtaatgctat 148081 ttcttggtct agtgccggag ctttaggatt cagaggttct cgtaaatcta ctccttttgc 148141 tgcgcaaatg gctgcagaaa cagctgctaa aggttcaatc gaacatggtc ttaaaactct 148201 agaggttact gttaaaggac ctggttcagg ccgtgaagct gcaatccgtg cacttcaagc 148261 tgctggacta gaagtcactg ctatcagaga cgtaactcct gttcctcata acggatgccg 148321 tccaccaaaa cgtcgccgcg tgtaatttgt ttgtatagat tttgtgtccc tgtcaataat 148381 gggttatgat acagttattt atgaaacgaa tgcaccgact cgttgcctga gcacatacgg 148441 gactaaacaa tggggaattt cggatggaat ctcatatgat tctattcgag gtttcgacgt 148501 tttgaaggag ggttttaagt aatgatcgag attgaaaaac caaaaatcga aacggttgaa 148561 atcagcgacg atgccaaatt tggtaagttt gtcgtagagc cacttgagcg tggatatggt 148621 acaactctgg gtaactcctt acgtcgtatc ctcttatcct cactccctgg tgccgctgta 148681 acatcaatcc agatagatgg tgtactgcac gaattctcga caattgaagg cgttgtggaa 148741 gatgttacaa cgattatctt acacattaaa aagcttgcat tgaaaatcta ctctgatgaa 148801 gagaagacgc tagaaattga tgtacagggt gaaggaactg taacggcagc tgatattaca 148861 cacgatagtg atgtagagat cttaaatcct gatcttcata tcgcgactct tggtgagaat 148921 gcgagtttcc gagttcgcct tactgctcaa agaggacgtg ggtatacgcc tgctgacgca 148981 aacaagagag acgatcagcc aatcggcgtg attccgatcg attctatcta tacgccagtt 149041 tctcgtgtat cttatcaggt agagaacact cgtgtaggcc aagttgcaaa ctatgataaa 149101 cttacacttg atgtttggac tgatggaagc actggaccga aagaagcaat tgcgcttggt 149161 tcaaagattt taactgaaca ccttaatata ttcgttggtt taactgacga agctcaacat 149221 gctgaaatca tggttgaaaa agaagaagat caaaaagaga aagttcttga aatgacaatt 149281 gaagaattgg atctttctgt tcgttcttac aactgcttaa agcgtgcggg tattaacacg 149341 gttcaagagc ttgcgaacaa gacggaagaa gatatgatga aagttcgaaa tctaggacgc 149401 aaatcacttg aagaagtgaa agcgaaacta gaagaacttg gactcggact tcgcaaagac 149461 gattgactag tttcccttgt gaactaggat tttcgtgtgt ttattattca gaaacagcat 149521 tccaataaag gaggggacat cacatgtcat acagaaaact aggacgtacg agtgcacagc 149581 gtaaagctat gcttcgtgat cttacaactg atttgatcat caacgaaaga atcgaaacaa 149641 ctgaaacacg tgcgaaagaa cttcgctctg tagttgaaaa aatgatcacg cttggcaaac 149701 gcggtgatct tcacgctcgc cgtcaagctg ctgcatacat ccgcaacgag gttgcaaacg 149761 aagaaaataa tcaagatgca cttcaaaaat tattctctga cattgcaact cgttacgagg 149821 agcgccaagg tggatacaca cgtattatga agcttggtcc tcgccgtggt gacggagcac 149881 caatggcaat tatcgaattg gtttaatcac atatttttgt gtatctaaag aagggcggga 149941 cagtttctaa ctggatctat gccctttttt tagatactgc aacttttaat agagagaaaa 150001 gcagagcatt agctgagagg aggccggttt tccatgaatc aaaatcagtt gatatcggta 150061 gaggatatcg tatttcgata tcggaaggac gcagaaagac gagcactaga cggcgtctcc 150121 ctgcaggtgt atgagggtga atggcttgca atcgtaggtc ataacggttc agggaaatca 150181 acactggccc gggcattgaa tggtttaatt cttcctgaat caggcgacat tgaggttgcc 150241 gggattcaat tgacagagga atctgtttgg gaagtgcgta agaagatagg tatggtcttt 150301 caaaatccgg ataaccaatt tgtcggaacg actgttcgcg atgatgtggc ttttggttta 150361 gaaaacaatg gtgtaccgcg ggaagaaatg attgagagag tagactgggc agtaaaacag 150421 gtgaatatgc aagattttct cgatcaagag ccgcaccatc tctccggagg ccaaaagcag 150481 agagttgcga ttgcgggggt tattgccgca cgtcctgata ttattatctt agatgaagca 150541 acatccatgc ttgatccgat cgggcgagaa gaagtgcttg aaacggtaag acatttaaaa 150601 gagcagggca tggcgactgt catatccatt acacatgacc tgaatgaggc agcaaaagca 150661 gacaggatca ttgtcatgaa tggcggtaaa aaatatgctg aagggccgcc tgaagagatt 150721 tttaaattga ataaagaact tgttcgaatt gggcttgatt tacccttctc attccagctt 150781 agccagcttt taagagaaaa tggactggct ttggaagaaa accatttgac tcaggaaggg 150841 ctggtgaaag agctgtggac attacaatca aagatgtaga gcatcgctat cagatgaaga 150901 ccccgtttga gcgcctagca ctgtatgata tcaatgcatc gattaaagaa ggaagctacg 150961 tagccgttat cgggcataca ggctctggca agtccactct tctacagcac ctaaatggtc 151021 tcctgaagcc gacgaaggga cagatatcac taggcagcac tgtcattcag gcagggaaaa 151081 agaataaaga tctgaaaaaa cttcgtaaaa aagtcggaat cgttttccaa tttcctgagc 151141 atcaattatt cgaagaaaca gttcttaaag atatttcatt cggaccgatg aactttggtg 151201 ttaaaaaaga agatgctgaa caaaaagcga gagagatgct gcagcttgta ggtttatcag 151261 aagagctttt ggacaggtca ccctttgaat taagcggggg acaaatgcgc agagttgcaa 151321 ttgccggcgt acttgcaatg gaccctgaag tgcttgttct ggatgaaccg actgcaggat 151381 tggacccaag agggcgaaaa gagattatgg acatgtttta tgagcttcat caacgtggga 151441 acttgacgac gatccttgtg acacacagca tggaggatgc agctgcatac gctgatgaaa 151501 tgattgttat gcataaagga acgatacaag catcaggcag tccgcgtgat ctgtttttaa 151561 agggtgaaga gatggccggc tgggggctgg atcttcctga aacaataaaa ttccaaagac 151621 accttgaagc tgcactgggt gtgagattta atgagcctat gctcacaatc gaagatgccg 151681 ctgccgaaat ccgtgctctt tttcagggag agaagacttt atgatggaca gcatgattat 151741 cggcaagtat gtaccgggga cttcacttgt gcaccggctt gaccccagaa caaaactgat 151801 cacgatcttt ttatttgtct gcattgtatt cttagccaat aatgttcaga catatgcgtt 151861 gcttggttta tttacaattg gcgtcgtttc tttaacaaga gttcctttct cttttttaat 151921 gaaagggctg aagccaatca tctggattgt cctttttacg ttccttcttc acattcttat 151981 gacacatgaa ggaccgatta tctttcaaat aggttttttc aaagtctatg agggcggtct 152041 ggttcagggg atattcattt ctcttagatt cgtctatttg attttaatca caaccttatt 152101 aacgcttacg actacaccga ttgagattac cgatggaatg gagcagctgc tgaacccatt 152161 gaaaaaatta aagcttcctg ttcatgagct ggctcttatg atgtcaattt ctttacggtt 152221 tattccgaca ctgatggagg agacagataa gatcatgaag gctcagatgg cgcgaggcgt 152281 tgattttaca agcgggcctg tcaaagaaag agtgaaggct attgtcccgc ttcttgtccc 152341 gctcttcgtc agcgcattta aacgcgccga agagcttgcg gtggcaatgg aagcaagagg 152401 ctatcaaggc ggagaaggac gtacgaaata tagaaagctt gtatggacag gaaaagacac 152461 ttctgtcatt gtcagcttaa ttgtattagc tgctttgtta tttttcttaa gggcttagag 152521 gtgctgtatg agactgaaat gcacgatttc ttatgacgga catttgttta acggttatca 152581 ggttcagccg ggcaaaagaa cggttcagga tgaactggag aaggctttgg ctgtcctgca 152641 taagtcaaaa gacagaattc cggtcgtttc gtctggaaga acagacagcg gggttcacgc 152701 agccggacag gtgattcatt ttgacactcc gctgtctatc ccggctgaga gatggccata 152761 tgccttaaat gcactgcttc cggacgatat cgcagtcaaa caggcagaaa ttgcggatga 152821 tgggttccat gcacgattta gcgcagtcaa aaaagaatat cgctactttg tatacacgga 152881 gaaacacccg gacgtattta aacggcatta cgcttaccat ttttcatatc gccttaatgt 152941 gcaggacatg agagaagcgg caaagcatct tatagggaca catgatttta cgagcttttg 153001 cgcggctaaa acagaagtgc aggacaaggt aagaacgata tacgaacttg attggactga 153061 gacggctgac ggcctgcaaa tgcggatcac aggcagcggt ttcttatata atatggtcag 153121 aattattgcg ggtactttgc ttgatgcagg tattggaaaa atttctcccg atgaggtgaa 153181 atccatgctg gaagcgaagg atcgcgaagc ggcagggcgc acagcgccgg ggcacgggct 153241 atatttatgg aacgtttact atgacaacta aaccaggtgt ataatatttt cttgacagag 153301 tctgcataaa gttataagat atcatatggt atgtatttca accccacgat aagccccgga 153361 acttattgtg ttgtgaaata gaacgtaatc gaagtttatt gaaaatgaca gatcatttag 153421 gagggaaatt caatgcgtac aacacctatg gctaacgcaa gtactattga acgcaagtgg 153481 ttagttgttg atgctgctgg caagacttta ggtcgtcttt cttcagaagt tgcagctatc 153541 cttcgcggaa aacacaaacc aacttacaca ccacacgttg atactggaga tcatgtgatc 153601 atcatcaacg ctgaaaaaat cgagttaact ggtaaaaagt taactgacaa aatctactac 153661 cgtcacactc aacatccagg cggattaaaa tcaagaactg ctcttgaaat gcgtacaaac 153721 taccctgaga aaatgcttga gcttgctatc aaaggcatgc ttccaaaagg ttctctaggt 153781 cgtcaaatgt tcaaaaaatt gaacgtatac cgtggttctg agcatccaca cgaagcacaa 153841 aaacctgaag tttacgaact tcgcggttaa ttaaaaagga ggttaccaat ttggcacagg 153901 ttcaatatta cggtactggc cgtcgtaaaa gctctgtagc gcgtgtgcgt ttagttccag 153961 gagaaggccg tatcgtcgtt aataatcgtg aaatcagcga acatatccca tctgcagctt 154021 taatcgaaga tatcaaacaa ccattaactt tgactgaaac agctggcact tatgatgttt 154081 tagtaaacgt acatggaggc ggcctatctg gtcaagctgg agcaatccgt cacggtatcg 154141 ctcgtgcttt gcttgaagca gatccagaat accgtacaac tcttaaacgt gcaggtcttc 154201 tgactcgtga cgctcgtatg aaagaacgta aaaaatacgg tcttaaaggc gctcgtcgtg 154261 cacctcagtt ctcaaaacgt taattttacg ttttcaaaaa gctctcgacc ttgggttggg 154321 agcttttttc tttcaataaa acgtggcagt cccgcataaa aataacaact gaatggacgc 154381 ttgacggggt taagcaaatt gtttgtttat aaacggtctc tttgtaataa tcatggtaga 154441 tttcattctt attcaattgg aagttcggtc aatgtttatt atcgttatgt gatcagccca 154501 gctccatcta accactgtat ctcatccgtt aaagttcact gctgattctt aacccggaga 154561 aacaatagct ctcattgcta atggctttat gtaacgaagt aaaagtaaat ctgatgatat 154621 aaatcacata tctcctttgt gatttttttg cgtttttatg aacttttttc taaatatgca 154681 aagggaaagc gatatcaatc tagaaatatt tgttatactc tatacattaa agtaaggaga 154741 agattcatga atgcgttagt agctcataat agcaaagcct gggataaaaa agtagaaaca 154801 ggcaatgaat ggactgttgc tgttgaacag caggttatcg aacaagcaaa aaaaggcaat 154861 tgggatataa gggtaacacc aatgaaagat gtaccgaagg attggtttcc gcctatcaaa 154921 ggtctgaaag tactctgttt agcatcaggc ggcggccagc agggtccagt tttggcagcc 154981 gcaggcgcgg atgtcactgt attagataac tcagaaaaac agctgaatca ggatagaatg 155041 attgctgagc gagatggtct gacgatacac actgtcaaag gaagcatgga cgatttaagt 155101 gtatttaatg atgaatcatt tgatgtcatt gtacatcctg ttgccaatgt ttttgttgag 155161 aatgtcctcc cggtatggaa ggaagcgtac cgtgtgttga aaaggaacgg cattctaatc 155221 tcgggttttg tcaatcctgt tgtatttctg tttgatacag aattagaaca gcaaggtgtt 155281 ttaaaagtaa aacactctat tccatacgct gacccagaag atcttccgaa acataaagtg 155341 aaaaaactga tcgaaaataa tgaggctctg gaattcggcc attccttaga agaccaaatc 155401 aaaggccaaa ttgatgccgg ttttatcgtt actggttttt atgaagataa aggcggtttt 155461 gtattagacc aatatatcca tacatattct gcaacaagaa gcgtgaaagt atgaaaagca 155521 gcgacctgtt agaggggctg cttttttcat aaccaattac agaacatttg ttcctcaccc 155581 tgcagaaagc tgatttttta tcaatgttac accttcattt gggcgaattt ccaaccgaat 155641 tcgggcattg tttcatcatc caaacctcaa aataatcggt aaaaggagag tgaatttata 155701 tggcagaagt actgtctttt atggatgtga aacgccaaaa ggattttgaa ttagaaaaga 155761 acttgctcaa agaactctct ctgagacaaa ttatccagtc tgttaaggat tgtttggaac 155821 cattatttcc atttttacat gatgaacgag atattattac cgaaggctgt attgattttg 155881 cgattgaagc ttatttgtta ggcgggcgtt ttgggatatt cggctattac ggagaatcaa 155941 tgcagagtat cagtgcccgc tctgcaagag aagaagaaga gctgcgtatg gagttttttg 156001 attatctcta taattggata cacgagcaat acgcaacatt tgataaaaac actgtttatg 156061 aagcggcacg caagttcatt aaagattggt ggacagcagg gtttgttcaa agagaaaaac 156121 agtgtaagct tcgcatgcgg taatcatatt tcccgaccct gtcccatagt tatgtaataa 156181 cggacaagcg ggaggggaag ggatgaggaa aaagcttaaa tggctcagtt ttttgctagg 156241 cttcatcata ttactatttc tgttcaagta tcagttcagc aataacgact cttggaagcc 156301 gtggagcctg cccttgagcg gtaaaatcat ttatctagat ccaggtcatg gcgggcctga 156361 cggcggagca gtcggcggaa agctgttaga gaaggatgtt accctggaag tggcctttag 156421 agtcagggat tatcttcaag aacaaggagc gcttgttatc atgaccagag aaagtgatac 156481 tgatctcgct ccagaaggaa caaaaggcta tagccgacga aaagctgagg atctaagaca 156541 acgagtcaaa ttaataaacc attcagaggc ggagctctat atcagcattc atcttaatgc 156601 gattccgtca caaaaatgga gcggagccca aagcttttat tacgggaaat atgcggaaaa 156661 tgagaaagtc gcaaaataca ttcaggatga gctgagaaga aatctggaaa acacaacccg 156721 gaaagcaaag cggattcatg gtatctactt aatgcaaaac gtcaccaaac cgggggcgct 156781 tatagaagtc ggatttttat ccaatccaag tgaagcaacg ttgctcggta aaccgaaata 156841 tcaagacaag gtggcatctt ccatatataa aggcattttg cgatatttca cagaaaaagg 156901 agaccctccg gagtaatgga gggttttctt gtggttctaa gcataagaca cccgccattt 156961 atgtatgata taataataat tgtaaacgaa tacacaaaag ggtgaggttc gatgataaga 157021 gaagatgaag taagaaaact agtcggagaa atgcgcgaac cttttcttca aagacctctg 157081 ggagaattgg atgccgttaa ggaaattaaa ataaagcctg aaaaacggca tatcagtgta 157141 aaagtcgctc ttgcaaaaac aggaactgca gaacaaatgc agattcagca agagatcgta 157201 aacgtattaa aaggggcagg agctgagaca gtcggccttc gatttgaaga gctgcctgaa 157261 gaaacggttg ctaaattccg ggcgccgtca gctgagaaaa aaacattatt aaatatggat 157321 aacccgccag tctttcttgc tgtagcaagt ggaaaaggcg gcgtaggcaa gtcaactgtg 157381 tcagtaaacc tagctatttc tctggctcgt ctagggaaaa aggttggttt aattgatgcg 157441 gatatttatg ggttcagtgt gccggacatg atgggtatca ctgtgcgtcc aacaattgaa 157501 ggagagaaac ttcttcctgt tgaacgcttt ggagtaaagg tcatgtcaat gggctttttc 157561 gtagaagaaa atgccccggt cgtatggaga gggccgatgc tcggcaaaat gctgaataat 157621 tttttccatg aagtagagtg gggagaagta gactatatcg ttcttgatct tccgcctggt 157681 acaggggacg ttgctctcga tgtacataca atgcttccga gctgcaaaga aattatcgta 157741 tctacgccac atccgacagc tgcttttgtc gcggccagag cgggctctat ggcgattaaa 157801 accgatcatg aggtcgtggg tgtcatagag aacatggctt attatgaaag tgcaaagaca 157861 ggggaaagag aatatgtgtt tggaaaaggc ggaggagata aactggctga ggaactaaac 157921 gtgcctttgc tcggcagaat cccattgaaa cagcccgatt gggataagga ccaatttgct 157981 ccgtctgttt atgacgaaaa tcatccaatc ggagaaatat atcaggacat cgcaaaaaaa 158041 atagatgcaa aaatgtcagt gcaggtataa aaggtgaacc gggattccag atcccggctt 158101 tccctttatt cactttcttt tgctgtgtct tttgctgctt ttttcagctc atcttcgaac 158161 tgctttttgt aaagcggact agaaagtgtt tcgttaataa cctcttctaa ataactgcgg 158221 aattcttggc tttttgccag ctggctgtac tttttatcca tgccgggatc ctgcataacg 158281 ctcatcagca tcttctggta atctggatcc ttcatcagct ttttaatcac tttttcatgc 158341 tctgtctgaa gagttttggc aaagccctca gcaaaatcag tgtcttcaaa gatgtttttc 158401 caaaattctt cacctttttt agatgtgagt gttttttcta ttgttccttt aattgcatct 158461 tggtcaatca ccagcgcttc attcatggca tcatcattta ataattcctt aatagctttc 158521 tttccatcat cagtttttaa tatatcaaca accatttttt tggtctgatc atagtccata 158581 tccgctgctt ggtcttttgg agcgcaagct gttacagata ataacaaaaa acagctcatc 158641 aatagcgttt tggcttttga catgcttaag ctcctttcac atacttgtct tacctttaat 158701 atgattcatc tgtttggaat tatacataac aaaatatcgc tgttcgcgat ttttgagggg 158761 atgaataaag aaatgaaaag ccgtggttta gttcgttttt tcttttctat tttagctgtc 158821 ggggcgctta tcacgagtat tgtgggtttt gctttaaagt ggggagaata tagagggctg 158881 tttctaacat ttgaagcggg acagattttc tctgttttat tttggtttat cggtgtaggc 158941 atgattttca gtgtgatcag ccaaatgggt tttttcgtgt ttttaacagt tcatcggttt 159001 gcgcttgaga tattaaggtc ctcctctttg tggaatttgc tgcagttgtt tttcatcctg 159061 tttgttgctt ttgatttaat gtacgtgcgt tttttatttt ttggagagag cggagaatcg 159121 ctggctggct atgcgtggtt accggtgttt ttattgatct ttggagtgat tacagcttat 159181 ataaagcaaa agcagtcctc taagaaaaca tttgtgtcat cgttattttt gatggttgtg 159241 attaccgcat tagaatggtt ccctgcatta agagtaaatg atgaggactg gctttattta 159301 atgctttttc cgttaatggc atgtaatgcc ttccaattgc tgatgctgcc gaagtttgca 159361 gcaaagtaat tactttacct ctgcggattt ggcatcagaa tttgcgatga gatcacccac 159421 ggttacattt tttaatcctt tttctttcag ctgatggatg atatcaggca atgcttcttc 159481 tgtttgtttt gcagaatcgg aggcatgtaa aagaataatg tctccaccgg aaacttgctt 159541 ggtcacattg tcgatgattt tttcaactcc gggatttgtc cagtcttgag agttcacact 159601 gtaatgaacg actgtataat tgtattgctt tgcgaccttt agaacattct tattgaattg 159661 gccggtaggg ggtcttaata gctgtatgtc tttgacccct aacttttcaa aggctgtttg 159721 cgcacggttc atgtcctttt ttatttcgct gctctctaaa ttggcatagt ttttataagc 159781 gtagcccatg ctcccgattt gatggccgtc ctttacgata cgggccactg tgtcgggatg 159841 gcgttctgcc caagaagcgg acaggaaaaa cgttgcgttt ttaatcccgt ttgctttcag 159901 agtattaagt atcggttctg ctctctcatc accccagctg atatcgaaag taagtgaaat 159961 atctttagag tctgtttctc ctttataaat ggctttaggt ccggtgtcag ttgaaaacac 160021 gggaagcggg acagctcttt ggatataaaa aaagctggca gctgcaaatg cggcgataag 160081 tataataatt aattgtttta cccgtttaat gtgccacaca tagaagtgat tcactgatga 160141 tgcctcctta tcttgtccat cattcttgtt ttacatctta tgagcatgga caattgaata 160201 taaccgataa aatgtctctt cacatacagc ctaaattggg tgttgacctt ttgataatat 160261 ccgtgatata ttattattcg tcgctgataa acagctgaca tcaactaaaa gcttcattaa 160321 atactttgaa aaaagttgtt gacttaaaag aagctaaatg ttatagtaat aaagctgctt 160381 cgttaagcgg cagtaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca 160441 tttttataaa tcgcacagcg atgtgcgtag tcagtcaaac tactttatcg gagagtttga 160501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cggacagatg 160561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 160621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 160681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 160741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 160801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 160861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 160921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 160981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 161041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 161101 gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc agaagaggag 161161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 161221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 161281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 161341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 161401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 161461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 161521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 161581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 161641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 161701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 161761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 161821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 161881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 161941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 162001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 162061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 162121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaagtaa tacaagatat 162181 cacatagtga ttctttttaa cggttaagtt agaaagggcg cacggtggat gccttggcac 162241 taggagccga tgaaggacgg gacgaacacc gatatgcttc ggggagctgt aagcaagctt 162301 tgatccggag atttccgaat ggggaaaccc accactcgta atggagtggt atccatatct 162361 gaattcatag gatatgagaa ggcagacccg gggaactgaa acatctaagt acccggagga 162421 agagaaagca aatgcgattc cctgagtagc ggcgagcgaa acgggattag cccaaaccaa 162481 gaggcttgcc tcttggggtt gtaggacact ctgtacggag ttacaaagga acgaggtaga 162541 tgaagaggtc tggaaaggcc cgccatagga ggtaacagcc ctgtagtcaa aacttcgttc 162601 tctcctgagt ggatcctgag tacggcggaa cacgtgaaat tccgtcggaa tccgggagga 162661 ccatctccca aggctaaata ctccctagtg accgatagtg aaccagtacc gtgagggaaa 162721 ggtgaaaagc accccggaag gggagtgaaa gagatcctga aaccgtgtgc ctacaagtag 162781 tcagagcccg ttaacgggtg atggcgtgcc ttttgtagaa tgaaccggcg agttacgatc 162841 tcgtgcaagg ttaagcagaa gatgcggagc cgcagcgaaa gcgagtctga atagggcgca 162901 tgagtacgtg gtcgtagacc cgaaaccagg tgatctaccc atgtccaggg tgaagttcag 162961 gtaacactga atggaggccc gaacccacgc acgttgaaaa gtgcggggat gaggtgtggg 163021 taggggtgaa atgccaatcg aacctggaga tagctggttc tctccgaaat agctttaggg 163081 ctagcctcaa ggtaagagtc ttggaggtag agcactgatt ggactagggg cccctaccgg 163141 gttaccgaat tcagtcaaac tccgaatgcc aatgacttat ccttgggagt cagactgcga 163201 gtgataagat ccgtagtcga aagggaaaca gcccagaccg ccagctaagg tcccaaagta 163261 tacgttaagt ggaaaaggat gtggagttgc ttagacaacc aggatgttgg cttagaagca 163321 gccaccattt aaagagtgcg taatagctca ctggtcgagt gactctgcgc cgaaaatgta 163381 ccggggctaa acgtatcacc gaagctgcgg actgttcttc gaacagtggt aggagagcgt 163441 tctaagggct gtgaagccag accggaagga ctggtggagc gcttagaagt gagaatgccg 163501 gtatgagtag cgaaagaggg gtgagaatcc cctccaccga atgcctaagg tttcctgagg 163561 aaggctcgtc cgctcagggt tagtcgggac ctaagccgag gccgaaaggc gtaggcgatg 163621 gacaacaggt tgatattcct gtaccacctc ctcaccattt gagcaatggg gggacgcagg 163681 aggatagggt aagcgcggta ttggatatcc gcgtccaagc agttaggctg ggaaataggc 163741 aaatccgttt cccataaggc tgagctgtga tggcgagcga aatatagtag cgaagttcct 163801 gattccacac tgccaagaaa agcctctagc gaggtgagag gtgcccgtac cgcaaaccga 163861 cacaggtagg cgaggagaga atcctaaggt gatcgagaga actctcgtta aggaactcgg 163921 caaaatgacc ccgtaacttc gggagaaggg gtgctctgtt agggtgcaag cccgagagag 163981 ccgcagtgaa taggcccagg cgactgttta gcaaaaacac aggtctctgc gaagccgtaa 164041 ggcgaagtat aggggctgac gcctgcccgg tgctggaagg ttaagaggag cgcttagcgt 164101 aagcgaaggt gcgaattgaa gccccagtaa acggcggccg taactataac ggtcctaagg 164161 tagcgaaatt ccttgtcggg taagttccga cccgcacgaa aggcgcaacg atctgggcac 164221 tgtctcaacg agagactcgg tgaaattata gtacctgtga agatgcaggt tacccgcgac 164281 aggacggaaa gaccccgtgg agctttactg cagcctgata ttgaatgttg gtacagcttg 164341 tacaggatag gtaggagcct tggaaaccgg agcgccagct tcggtggagg catcggtggg 164401 atactaccct ggctgtattg accttctaac ccgccgccct tatcgggcgg ggagacagtg 164461 tcaggtgggc agtttgactg gggcggtcgc ctcctaaaag gtaacggagg cgcccaaagg 164521 ttccctcaga atggttggaa atcattcgca gagtgtaaag gcacaaggga gcttgactgc 164581 gagacctaca agtcgagcag ggacgaaagt cgggcttagt gatccggtgg ttccgcatgg 164641 aagggccatc gctcaacgga taaaagctac cccggggata acaggcttat ctcccccaag 164701 agtccacatc gacggggagg tttggcacct cgatgtcggc tcatcgcatc ctggggctgt 164761 agtcggtccc aagggttggg ctgttcgccc attaaagcgg tacgcgagct gggttcagaa 164821 cgtcgtgaga cagttcggtc cctatccgtc gcgggcgcag gaaatttgag aggagctgtc 164881 cttagtacga gaggaccggg atggacgcac cgctggtgta ccagttgttc tgccaagggc 164941 atcgctgggt agctatgtgc ggacgggata agtgctgaaa gcatctaagc atgaagcccc 165001 cctcaagatg agatttccca ttccgcaagg aagtaagatc cctgaaagat gatcaggttg 165061 ataggtctga ggtggaagtg tggcgacaca tggagctgac agatactaat cgatcgagga 165121 cttaaccata tttttgaatg atgtcacatc tgttatctag ttttgagaga acactctcaa 165181 tttgtttggt ggcgatagcg aagaggtcac acccgttccc ataccgaaca cggaagttaa 165241 gctcttcagc gccgatggta gtcgggggtt tccccctgtg agagtaggac gccgccaagc 165301 agatttatta attctaccat gtttgtttat gaagctttat attattccgc agtagctcag 165361 tggtagagct atcggctgtt aaccgatcgg tcgtaggttc gaatcctacc tgcggagcca 165421 ttgcttccat agctcagcag gtagagcact tccatggtaa ggaagaggtc agcggttcga 165481 gcccgcttgg aagcttaaat gtattattac caaggtttct cataaggaga aagctttttt 165541 tattgcgata tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 165601 gggttcgaat cccgtcttcc gctccattta tcctaacggg atattgtaaa ttgaattgcg 165661 cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg gttcgactcc 165721 tctcgggcgc gccatatctt ttaatagaat agataggaaa tcgggaagta gctcagcttg 165781 gtagagcaca tggtttggga ccatggggtc gcaggttcga atcctgtctt cccgaccatt 165841 ttttatgggg ccttagctca gctgggagag cgcctgcttt gcacgcagga ggtcagcggt 165901 tcgatcccgc taggctccac caaaagtttt taaaaaagtt attgactttg aagaagtgac 165961 attgtatact aataaagttg ctttaacaaa gcggacaaac aaaatgatct ttgaaaacta 166021 aacaagacaa aacgtacctg ttaattcagt ttttaaaaat cgcacagcga tgtgcgtagt 166081 cagtcaaact actttatcgg agagtttgat cctggctcag gacgaacgct ggcggcgtgc 166141 ctaatacatg caagtcgagc ggacagatgg gagcttgctc cctgatgtta gcggcggacg 166201 ggtgagtaac acgtgggtaa cctgcctgta agactgggat aactccggga aaccggggct 166261 aataccggat ggttgtttga accgcatggt tcaaacataa aaggtggctt cggctaccac 166321 ttacagatgg acccgcggcg cattagctag ttggtgaggt aacggctcac caaggcaacg 166381 atgcgtagcc gacctgagag ggtgatcggc cacactggga ctgagacacg gcccagactc 166441 ctacgggagg cagcagtagg gaatcttccg caatggacga aagtctgacg gagcaacgcc 166501 gcgtgagtga tgaaggtttt cggatcgtaa agctctgttg ttagggaaga acaagtaccg 166561 ttcgaatagg gcggtacctt gacggtacct aaccagaaag ccacggctaa ctacgtgcca 166621 gcagccgcgg taatacgtag gtggcaagcg ttgtccggaa ttattgggcg taaagggctc 166681 gcaggcggtt tcttaagtct gatgtgaaag cccccggctc aaccggggag ggtcattgga 166741 aactggggaa cttgagtgca gaagaggaga gtggaattcc acgtgtagcg gtgaaatgcg 166801 tagagatgtg gaggaacacc agtggcgaag gcgactctct ggtctgtaac tgacgctgag 166861 gagcgaaagc gtggggagcg aacaggatta gataccctgg tagtccacgc cgtaaacgat 166921 gagtgctaag tgttaggggg tttccgcccc ttagtgctgc agctaacgca ttaagcactc 166981 cgcctgggga gtacggtcgc aagactgaaa ctcaaaggaa ttgacggggg cccgcacaag 167041 cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaggt cttgacatcc 167101 tctgacaatc ctagagatag gacgtcccct tcgggggcag agtgacaggt ggtgcatggt 167161 tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccttgat 167221 cttagttgcc agcattcagt tgggcactct aaggtgactg ccggtgacaa accggaggaa 167281 ggtggggatg acgtcaaatc atcatgcccc ttatgacctg ggctacacac gtgctacaat 167341 ggacagaaca aagggcagcg aaaccgcgag gttaagccaa tcccacaaat ctgttctcag 167401 ttcggatcgc agtctgcaac tcgactgcgt gaagctggaa tcgctagtaa tcgcggatca 167461 gcatgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca ccacgagagt 167521 ttgtaacacc cgaagtcggt gaggtaacct tttaggagcc agccgccgaa ggtgggacag 167581 atgattgggg tgaagtcgta acaaggtagc cgtatcggaa ggtgcggctg gatcacctcc 167641 tttctaagga tattatacgg aatataagac cttgggtctt ataaacagaa cgttccctgt 167701 cttgtttagt tttgaaggat cattccttcg aaacgtgttc tttgaaaact agataacagt 167761 agacatcaca ttcaagtaat acaagatatc acatagtgat tctttttaac ggttaagtta 167821 gaaagggcgc acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg 167881 atatgcttcg gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca 167941 ccactcgtaa tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg 168001 ggaactgaaa catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg 168061 gcgagcgaaa cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc 168121 tgtacggagt tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag 168181 gtaacagccc tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac 168241 acgtgaaatt ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga 168301 ccgatagtga accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag 168361 agatcctgaa accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct 168421 tttgtagaat gaaccggcga gttacgatct cgtgcaaggt taagcagaag atgcggagcc 168481 gcagcgaaag cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt 168541 gatctaccca tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca 168601 cgttgaaaag tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat 168661 agctggttct ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga 168721 gcactgattg gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca 168781 atgacttatc cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag 168841 cccagaccgc cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct 168901 tagacaacca ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac 168961 tggtcgagtg actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga 169021 ctgttcttcg aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac 169081 tggtggagcg cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc 169141 ctccaccgaa tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc 169201 taagccgagg ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc 169261 tcaccatttg agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg 169321 cgtccaagca gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat 169381 ggcgagcgaa atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg 169441 aggtgagagg tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg 169501 atcgagagaa ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg 169561 tgctctgtta gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag 169621 caaaaacaca ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt 169681 gctggaaggt taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa 169741 cggcggccgt aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac 169801 ccgcacgaaa ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag 169861 tacctgtgaa gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc 169921 agcctgatat tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga 169981 gcgccagctt cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc 170041 cgccgccctt atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc 170101 tcctaaaagg taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag 170161 agtgtaaagg cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc 170221 gggcttagtg atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc 170281 ccggggataa caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc 170341 gatgtcggct catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca 170401 ttaaagcggt acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg 170461 cgggcgcagg aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc 170521 gctggtgtac cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa 170581 gtgctgaaag catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga 170641 agtaagatcc ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat 170701 ggagctgaca gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct 170761 gttatctagt tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca 170821 cccgttccca taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt 170881 ccccctgtga gagtaggacg ccgccaagca attgcacatt agtgtaattt tttaaaaaag 170941 ttattgactt tgaagaagtg acattgtata ctaataaagt tgctttaaca aagcggacaa 171001 acaaaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca gtttttaaaa 171061 atcgcacagc gatgtgcgta gtcagtcaaa ctactttatc ggagagtttg atcctggctc 171121 aggacgaacg ctggcggcgt gcctaataca tgcaagtcga gcggacagat gggagcttgc 171181 tccctgatgt tagcggcgga cgggtgagta acacgtgggt aacctgcctg taagactggg 171241 ataactccgg gaaaccgggg ctaataccgg atggttgttt gaaccgcatg gttcaaacat 171301 aaaaggtggc ttcggctacc acttacagat ggacccgcgg cgcattagct agttggtgag 171361 gtaacggctc accaaggcaa cgatgcgtag ccgacctgag agggtgatcg gccacactgg 171421 gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc cgcaatggac 171481 gaaagtctga cggagcaacg ccgcgtgagt gatgaaggtt ttcggatcgt aaagctctgt 171541 tgttagggaa gaacaagtac cgttcgaata gggcggtacc ttgacggtac ctaaccagaa 171601 agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag cgttgtccgg 171661 aattattggg cgtaaagggc tcgcaggcgg tttcttaagt ctgatgtgaa agcccccggc 171721 tcaaccgggg agggtcattg gaaactgggg aacttgagtg cagaagagga gagtggaatt 171781 ccacgtgtag cggtgaaatg cgtagagatg tggaggaaca ccagtggcga aggcgactct 171841 ctggtctgta actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 171901 ggtagtccac gccgtaaacg atgagtgcta agtgttaggg ggtttccgcc ccttagtgct 171961 gcagctaacg cattaagcac tccgcctggg gagtacggtc gcaagactga aactcaaagg 172021 aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 172081 accttaccag gtcttgacat cctctgacaa tcctagagat aggacgtccc cttcgggggc 172141 agagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 172201 cgcaacgagc gcaacccttg atcttagttg ccagcattca gttgggcact ctaaggtgac 172261 tgccggtgac aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc 172321 tgggctacac acgtgctaca atggacagaa caaagggcag cgaaaccgcg aggttaagcc 172381 aatcccacaa atctgttctc agttcggatc gcagtctgca actcgactgc gtgaagctgg 172441 aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc cttgtacaca 172501 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cttttaggag 172561 ccagccgccg aaggtgggac agatgattgg ggtgaagtcg taacaaggta gccgtatcgg 172621 aaggtgcggc tggatcacct cctttctaag gatattatac ggaatataag accttgggtc 172681 ttataaacag aacgttccct gtcttgttta gttttgaagg atcattcctt cgaaacgtgt 172741 tctttgaaaa ctagataaca gtagacatca cattcaagta atacaagata tcacatagtg 172801 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 172861 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 172921 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 172981 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 173041 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 173101 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 173161 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 173221 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 173281 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 173341 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 173401 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat ctcgtgcaag 173461 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 173521 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 173581 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 173641 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 173701 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 173761 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 173821 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 173881 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 173941 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 174001 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 174061 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 174121 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 174181 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 174241 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 174301 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 174361 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 174421 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 174481 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 174541 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 174601 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 174661 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 174721 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 174781 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 174841 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 174901 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 174961 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 175021 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 175081 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 175141 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 175201 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 175261 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 175321 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 175381 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 175441 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 175501 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 175561 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 175621 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 175681 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 175741 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 175801 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 175861 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag caagcttaaa 175921 cccagctcat tgagctgggt tttttgtttt atatctgtgc cgatttgctt tcgtcagtat 175981 ccattttatc aagcttctgc tttttaaagt tttctaatac ttttgaattc caatacaatc 176041 cctagcatga tcaacatgag agtcataaat aatcaaaatg cagtttgtac gggagactca 176101 tccagactcc atccgactgc gattggcagg atagagccgc caatccattg gcagcgaaca 176161 gcatgcttgt cgtttgttct gtttttccat gataaaattg attggtgaca ataaaataat 176221 ggcgaacatg ccggccataa ataagtccta agaaaaaact aagaataatc cctgcaaaag 176281 ctgttttatt gattgccaaa atacagagtt aaatgaggcc gctcatattt atcagcctga 176341 gataatgatg ataggttatt ttttcggaaa ccagctcggg ttgccaaatg agagaaaaga 176401 tattactgtc attaaaacga ttcttggttt catccggata tgataaaatg tctcagacta 176461 tatttgagcc atttttttct tcagcaatca tcttgcgtaa ttgataaaaa tttattatga 176521 tactctttgt atgacaactc cttgcctcaa tacaatatac tcaacgtttc cccgttttct 176581 ccggtcgttt ttcttttcat tttctcccgt aaaataaaaa aagctcccaa tacaatagat 176641 atggtgcgga tttatttttt actaaaaagg agtcgttata tttgaataat agttttacat 176701 taaaacagca atggttcggg aatatccgaa aagacattct tgctggcatt ttagttgcgt 176761 tagcgttaat acctgaagcg attggctttt ctattatagc cggtgtggat ccgatggtcg 176821 gtctttatgc gtcattttgc atagccatta ttatttctat ttttggtggc agacctggca 176881 tgatttcagc tgcgacaggc tcaatggcag tcgttatggt gtcgctggtt gctgatcatg 176941 ggcttcagta tttatttgcg gctacgattt tgacaggcat tattcaggtg attttaggta 177001 tcagtaaaat tgcaagatta atgaaattca tcccgcgttc tgtgatgatc gggtttgtga 177061 atgcgctggc gatccttatc ttctctgcgc agcttcccca gtttgaaggt gcttcttgga 177121 gcatgtatgc gatgcttgcc gggtcgttgg ttattattta tgtgctgcca aggtttacga 177181 ctgctgttcc gtctccgctt gtggcgatta ttgtgatgac aattattgcg gtcactttcc 177241 atgtggatgt gcggacggtt ggtgatatgg gcaatatttc tagttcattg cctcatttct 177301 taatccctga tgttccgttt acctttgaaa cactgcaaat tatttttcct tattcaattg 177361 ctttagcgtt tgtcgggttg cttgaatctt tgctgacagc acagattatt gatgaaatga 177421 cggatacgga tagtgataaa aataaagaga gccgcggaca gggaattgcg aatatcgtga 177481 ctggattctt tggcggaatg gcaggctgcg ctatgatcgg acaatctgtc attaatacaa 177541 aagcgggcgg tcgcggacgt ttgtcagcat ttgttgccgg tgcttttctg atgtttttaa 177601 ttgcggtgtt aagtcatgtc gtggtgaaaa tcccaatggc ggcgttagta gctgtaatgg 177661 ttatggtgtc tgtcggcact tttgattggt cttctttaaa aggtctcaaa aaagcgccgc 177721 tcacggactc gattgtcatg gttgtgactg tggttacggt tgttgtgacg gatgacttat 177781 ctaagggtgt atttgtcggt gttcttttaa gtgccgtgtt ctttgtagca aaaatctcga 177841 agctgaaaat cgtttctcat gcagaggatc aaaagcttag aacgtatcaa gtgaaggggc 177901 aaatcttttt tgcgtcagtg actgatctta cgaatgcgtt tatatatcaa gaggatattg 177961 agcgggttgt gattgactta actgaagctc acgtatggga cgattctggt gcggccgcac 178021 ttgataagat tgttgcgaag tttaaggaac aaggcattga agctgagtta aaaggtttga 178081 ataaagcgag taaatctcta atgaaacaga tggcataaaa tagagaagcc cagatgaatg 178141 agatctgggc ttttttatat aacatacact taagcagcat tgatataata gagagaagag 178201 aaattttaaa taggggactt gcatatgatg cttcagaagc tgaaccgtgt attggggaga 178261 gtgatgccgc tgttaacgcc gactagtgtg gtgctgggcg tgctgctgtc tcagttttta 178321 aatgggtatg aatgggctgt gccttggatc tttgctttta ttacgtttgc aggcagtttg 178381 agcgcgaact ttcaatcttt gagacatgca ttgtctcatc ctctccctat gattcttgca 178441 ctattcgttc ttcatatttt catgccgctt tttgcttggg gcagcggcca tcttatattt 178501 aaaggtgatc ctttgacgat taccggttta acattggctg ttgtgattcc tacggggatt 178561 acaagcttga tttgggcagc gatgtacaaa gggaatgtcg gtttgacact ttcgattatt 178621 ttagttgata ctgtgctgtc accgctaatc gtaccgctga gtctttcatt gctggccggc 178681 gctcaggttc acatggatgt gtggggaatg atgaaaggtc tgattgtaat ggtcgtgatt 178741 ccttcttttt tgggcatgct gtttaatcag atgtcatctc cagaaagaac tgcgtttgtg 178801 agcagtgcgc tgtcgccttt ttcaaagctt tgcttgatgg cagtgattgc gattaacagt 178861 tcagcgattg ctccttattt caaatccatt gatttgagat ttgcaggaat agctgtaacg 178921 gtattcttta tcgcgttaac aggttatgcc gctgcttggc tgatcggaaa aatgatgaaa 178981 aggcggcaag aggaaatagt ctctcttata tttacgggag gcatgaggaa tattagtgcc 179041 ggcgcagttc ttgccgttac gttcttcccg tctcaggttg ccgttcctgt tgtgatcggc 179101 atgctgtttc agcagatatt ggctgctttg tttggctata tgctgaatcg ttttgaatta 179161 aaaccaatgt tgcagaaggc ataaaaaaac cgctcatagg gttgagcggt tttttccgta 179221 tagccattcg agcgcgttga tgaactgttt gcagaaatac ttgtggtggt gcaccgctcc 179281 tttttcaatt gaaagacaca actggtcttc agtgaagcct ttttctttta gactttgatg 179341 aacttgcttt gtttttttca gcatatgtcg ctgaatggat tgtttttcac ggccttcttc 179401 actcccgata gacatgaaaa cacgtgcagt gccgggcttt aaagaagata tatgaatggt 179461 ttccgctgcg ttctcgtacc agtatgaacc tgatatagag cctattttcc cgaacattga 179521 cggatatttt aatatggcga acattgagat gaggccgcct aatgaggcac cgatcattcc 179581 tcttgactgc ggttccctgg tgacgttcca gttttcttcg attagcggaa tgaactggtt 179641 cgttatatca gacagatagt gatatcccat tccgccgaag tccgtgaacc gatcactgag 179701 tgatgcagcc ggccatgggg tgtattcatc aagccggttt tcgggttcga taccgatcag 179761 cacgagttca gggagccttt gctgttgaaa ggcgctttct agtaattcga tttggttttg 179821 gaacaaagaa ctgccatcct gcacgtaaac agcaggaaat cccccgctgt ctgtgctgta 179881 ggaaggaggg aggtacagcg tgaacctcct gttgccggct ttgtgttctg aaagagatcc 179941 tttcaagcat tctccccctt tttttgcttg aaaagcagat ataagaaata aggaactccg 180001 aggatcgcca aaatgatgcc tgcgggcact tctgcgggct gaaaaaacag ttttccggca 180061 aagtctgcgc ttatcacaag aagcatcccg attaaaccgc tcagtggcag gatatagcga 180121 tgttcgacgc cagccagtct ccgtgagata tggggagcaa ttaagccgac aaacgccata 180181 cttcccgcta cggagacaca ggcgctgatg attgctacac aggcaacgag aaggatggtt 180241 ttttctttat ttgatgaaat accgaggctt ctgactgtgt cttcatcaaa acgaatggtg 180301 tcgagcaggc gggatttgcc gataagaatc ggtataaaca gcagcatcca tgggagtaca 180361 gctgtaatat acgtccagtt ggcagaccag atgcttccgt ttttccacac catggccatt 180421 tgatagtctt gcgggtccat ttttaaagat aaaaacaaag acagggcgct gaatcctgaa 180481 ttgatcgcaa tccctaccaa aataattctt cctgaatcta aattgcctct gtgccatgca 180541 aatatgtaaa tcaggatcgc cgcgatgagc ccgcctatca atccaaagag cggcattccc 180601 atcgctgcag ctatggatgt cacttccttc tggccttgga ataagagcat aaacgctaca 180661 atgccagctc ctgcccctgc gttgattccg agaattccag ggtcagcaag cccgtttctc 180721 gtgatggcct ggataacagc gcctgcaatg ccaagaccga gtccaataat agcagccatg 180781 acaacccgcg gcagtcttaa atcgaacagc aaaatttcat actgcggatt cgggtcgatt 180841 tgaaaaagag tggagagcag ctcagcagga cgaacagaaa atgatccgct cgttaagctg 180901 aaatagctga caacaagaat caaagcgatg aacaatgcat attttttagc cattttgctc 180961 ccctcctttt cgtttaatta aataaaggaa gaaaggtacg ccgataatgg atgttacgac 181021 ctcaatcggt gtttcaaacg gatagttgat aaatctgctt gcgagatcac acagggttaa 181081 aaagattccg cccaaaatac aggaacacgg aatcagcctg ctgtaatcag agccgacgag 181141 aaatctcgtg atatgcggaa caaccaaccc gacaaacgca atttttccgg ccagcgctac 181201 ggcactgccg gttagaatga tgacggaaag catcgccatg attttaatgg tttttttctt 181261 ttgccccagg cttttagaaa tgtcgtcccc taatgataca gcggttacct ttttgctgag 181321 agaaatggcc attataatgc caatcaggaa aaacggagcg gcaagcttca ggaaatctgg 181381 actcatttga tgaagtctgg cactgtacca gaaactgaga tcctgagaaa tttgaaaata 181441 aatcgacatg gccgctgata agctgctgag cagcatgctt gtgactgtgc cgatgatggc 181501 gagctgcacg ggggtaaatc cgtttggcat catggcggca aggccgaata ctaacaccgc 181561 tcctaacgct gagccgataa aagagtatat catcatttca atcgaagatg attgcgggag 181621 cagaaccatg caaagcgtaa tgataaacgc tgaaccatct gaaacaccca taatggatgg 181681 cgaagctaaa taattgcgcg taatgccctg cataagcgct ccagaaacag caagggctgc 181741 ccctatgagc agagcgccgg cagcccttgg aatccgggaa tgccatataa tttgatggtc 181801 tgtgtttccc ggatcgaaat gaataagaga tgtaaaaaca atatctgtgc tgagatgctt 181861 tgccccataa aggattgaaa gcaaaagtga cagcgctata gcaaatggag aagtaatcaa 181921 tatgatacgt gtccactgtt ttgaatacat acaaaaacct actctgaatt agttttgtgt 181981 caatttttca gcagccgctt tcaggaaacg gactttgctc caagctgtgc cgccttgtgc 182041 gagagggtcc actgagttga catacacatg gtcttctttg actgctttaa ggcttttcca 182101 gattggattt ttctctaaat cttttaaggc atcaggtttg tctgcatttt catcatcaga 182161 aaattggacg aaaatatggt ccgggttcat ttcacttaat ttttctaatg aactcagctc 182221 ttgcgctttt gcagccttta cttcgttcgg cgccttaagg cctaaatcac cgtatagtgt 182281 ggagttgaaa tacacctgtt cagggtaaat gtaaatgttg ccttgtctga ttctgatgac 182341 aagcgctttt gaatctttcg ctttatcgtt gatttttgtt tttatttctt ttagatcctg 182401 ttcatagtct gcaataattt tctttgcttt tttctctttt ccagtcagct gggcaagaag 182461 catcatgttt tccttccagt ttgaagagat atgagaaact gggatcgtcg tgcctgctgt 182521 gctgattttt tgcagcgttt tttccggaaa ctttgttgaa gcaaggataa catctggctt 182581 catttcaaga atcttttcaa tatttggctc cattttttct ccggttggtt cggctttatc 182641 agtgatgtct ttgaacatat cagggaattt gccggagaat gaaattgcgc cttgcggatg 182701 aacgtcaagc aatttcgcgt cttccattga ttcaacgctt cccgtaatgg caattttgtc 182761 tgtcggtaca gttacttcat atgttttatc aaggtattca attttcttct tctcagatgc 182821 tgtgccgctt gccttgctgg cagttgattc atttttgctg ccgcaagctg ccgccgtcag 182881 cgcgagaagt aagattaata aggtaagaga tatctttttc atctatagag cctcctgttc 182941 aattgataac tattatcaat tggaattata gagaatgaac agatataaca ccatggacaa 183001 attcctgatt tatcatggac aatctccgga tagtaaagaa acagtttgct gaacgatgcg 183061 ttcgtgcccg caagctgagt attcattcca cgggtcaagg gatagaagat aaacacggtt 183121 atctcgtacc gcgcttaggt tttgccatgc ttctgtctgc tgtaattgct ggtagtaagc 183181 tatggtctcc ggctctttaa aaagaaaaag catcatacag tcagcttggt aatttgcgat 183241 attttctaac gaaatcgctt gttctgaagg tgtgtcagcc gttgttgccg agctgaatcc 183301 taaatcccca aagaaaactt cgcggacact tcggttatga gccagataga agttttgctt 183361 atgcagcctc aaaaagagaa aacgcagccc ttgaacgtgc tgaagtgttt ttttggcggc 183421 cgttgtctgc tggtcataat ccgctagcca cttttctgct tcggactcct cctttaaaaa 183481 tgaggcagtt tgcagaaagt gggttctcca gctttcttct gaaggaaggt acatgacttc 183541 tgcgatgcga ttcaggcgat cttgttcttc tggagaaata gaatccatgc tgacaatcac 183601 atctggttct gcctgtgata acgtgtacag gttttcttcc cacttttcat taaaccggta 183661 tgcactgagc tggacgggta tatctgtcga ataatgctga tagtagtaag acgtccattt 183721 cggatgcaga gcggccgcaa aaggtatgtg gtgaagaggg atgagatggc ccattgtgcc 183781 ccttccgtat gcggcgattt tctttcggcg ttttttcata tagcttgtag gtgaacagcc 183841 tgtatatttt ttaaagattc tgctgaaata aaattcatct tgataaccgg tttggtgtgc 183901 gatttctttc aatttgcagt ttgattttgc catgagccgt tttgcctttg tgattcgtgt 183961 tttcgtaata aattctgtta cgctctgtcc tgtccatttt ttaaagcttt cactgtagtg 184021 tttggcactg attcctgcca tttgcgacag ctgggcaagc gtgatttttg tatcggcatg 184081 ggtttcgata tagtgttttg ttttttcgat tgctgaatgt gtatccgttt gatcagataa 184141 actggcagta aaaagatcat aaatcaggct ttgtacttca atcacacatt ttagctgaga 184201 aagctgagac gattcattcc atagtgcggc aagctcttga agccggactg caagattttc 184261 gatatgtgaa acattcataa gcttcagttt ggctaattcc gattctgtgc acggtgtgaa 184321 aatatcttgc ccggtttcct tgatatagct tagaagcctg attatacagg catctatatg 184381 tccatcggct gctggcgtaa agccaaaggt ctcgttaggc ggacaaacat aaagtgtctt 184441 tttttgcaga ggattggtgt ttgttccgat cgaaatatag ccgtttcctt ttaaatgaaa 184501 aatcagcacg aatgaatcgg ctaattgctg ttctgagaag agatcacttg tcttttttag 184561 atattcaatt tgtactggtt gataaatcac tgcattttgc acgagtagac caccttttca 184621 gaagctttca attgataatc attttcaata aaaattgtac caaataaatg aaagttttcc 184681 tatataaagc gggtgggttt ttagcatgaa aaaaaccctt acttatgtgt aaaagtaagg 184741 gtctttcgtt caataagaat atgttacacg tgtaacatac gatgcttatg ttctaataaa 184801 tgagatactt ttttcttgtt ttgctgaatt gttggagtgt tttttcatag ctgtttatga 184861 tgttctcaac cgaagttcca ttttcaattt ttgtcctgat ccagccgttg cctgccagtt 184921 tatcgaatga acctgttgac aggaactcaa aatcctcagg atagagatcg tgtatggttt 184981 taatgactga aagacccgtt ttaacggctt caaacttatc tctgtctgtc acatagagct 185041 gcacaccgtg gcaaagcgtt ccttgatgtt tagaaaacgt cggtgtgaag gatgctgccc 185101 taaatgtaac gcccggcaaa tggaggctgt ttaatgtttc ttcaagttct gtgcttttga 185161 taaagggagc tccgatcaat tcgaatggct ttgttgtccc tcgcccttcg gatatatttg 185221 ttccttcaat cagcccggtt gcaggataaa caaatgtgct ttccaccgtc ggcatgttag 185281 gcgaagggag gacgaaaggc aatcgggtat cgtcaaaatc catttttcgt ttccagtgtt 185341 tcatttttac cactgtaaga tcggcatcaa tactaaattc tttgttgaac agtgaagcca 185401 attcgcctat cgtcatccca tgcttcaatg gaatgggata caatccgaca aatgaggcgt 185461 attcaggttc taagattggt ccttcaatat gattcccgcc ttgaggattc ggacggtcca 185521 gcaccataaa tggaatgccg ttttctttag cggcttccat tgcgtatgcc attgtataaa 185581 tgtacgtgta gaaacgggtc ccgacatcct gaatgtcaaa cattagaata tcgacatttt 185641 taagcatttc tggagtcggt tttttcgttt ttccgtagag gctgtatacg ggaaccccgg 185701 ttttttcgtc aatgtaagag cctacttcgt ctccagcctg ggcgtcaccg cggacgccgt 185761 gttcagggcc gaataaagct gtcagtttga tatccgggtt ctcgtaaagg atatcgacac 185821 tgctttttag agatgtgttt actccggctg gattggtgat cagtccgatg cgttttccct 185881 tgagctgttt tttatagtct ggcaagagcg tgtctatccc agtctggact ttaggttttt 185941 tagctgtttg attctttgaa tcgggtgaag cagaggcagc ggttatcgtt ccgaacatca 186001 tgagccctgt cagaaaagcg aatattgttt ttctcatgtg tccctcctta ttaaagcggt 186061 cttcccgttt tgatatttaa tccgtagcca agtgggtaaa gggtgttccc tggtttcgtg 186121 actgacggaa tgtcaactgg aagtgtgcct ttaggttttg cctggccgaa tatcgccatc 186181 actccggccg gaatattagg ttgaagataa cggccatttg cgtatccttt aaagccatag 186241 actgcaatca gtgcttttgc ttcttcgaaa ttggctgcgt cataggggtt gcgcaggctc 186301 attaagacaa atggtttgtt gtgctgcagt gcggctttca tgacagctct cggaaacacg 186361 gtggcccatt tgcttgaatc tgatattgtg tcgtcgatga caccgtcgtt gacgacaggg 186421 tcatttttga cgacatagga gccggtaatg atataatcag cctcttttac ttgtttttca 186481 tgctcggtct taaatacttg gctggcaaag ttcattttgc tgagggatac gggtttgatt 186541 ttctttcgct tgatgagatc gtgaatggtt tgttcgattg aagcagtttg ttcttcgtaa 186601 ggtgccacaa ttaagattcg gctgcctttt ttaggcttga acggcaaagt gtgctgttca 186661 ttttttaata cagttactgc tttttcagct aattttttct ctgctttcag gtgctgcttg 186721 cttcctacga tttttttggc tttggctatt ttttcttttg tactgtcgct gtttcgcgct 186781 ggatacatgc cgcgttttat tttcagggaa atgattcttt caactgaatt gttgatttgt 186841 tgttcaggaa tatccccgtt tttcacggct tctttcaaag cttgaataac acgtgcgaat 186901 ttctgttctt ctttcaatga agtgactgag gctggcatta atgcaatatc gacaccagct 186961 tttacggcca tgaccacagc ctcttcctgt ccgaaatgat ctgcgattgc cttcatattg 187021 agcgcatcgg taacgatgac cccattaaag cccatttcct gacgaagaag acctgtcatc 187081 actttttttg aaagtgtagc tggaaccaga atgtccgatc catcgagttt gcttttgtaa 187141 gtggtgtcat caaaggcggg aaactgaaca tgggctgtca tcaccatatc agcaccagca 187201 tcaattgctt tttgaaaagg ataaagctcg acctcacgaa gccgttcttg gccatgggaa 187261 acgagcggca gtccataatg gctgtcaacg tccgtgtctc catgtcccgg gaaatgtttg 187321 agggcagacg cgatatcctg ccgctgcaac cctttcatcg tatataaacc gaggcgtgat 187381 gtcagttctc gattggagct gaatgaccgt acgccgatta caggattatc aggattattg 187441 ttaatgtcca cgacagggct gaaatctgta ttgatgccta aggcagagag ctcttttccg 187501 atgatgctgc cggtctgata cgcattgatt ctgcttctgg ctgcgcccag cgccatattc 187561 cctgggaaat tagtgccctc ccctaacctc gttacaatgc cgccttcctg atcaatactc 187621 agcatgagcg ggatttttgg acttgccttt tggtaatcgt ctgtcagttg gacagtttgt 187681 tttgttgttt ttacattttc tgcaaaaagg atgatgcctc cgaattgata tttcttgacg 187741 aggctggcga cttcatcatt catttttgta agggcttgcg gagaggactc gccttccttt 187801 tgccaatttc taaaatcagg catcagcatc tggccgagtt tttcatctaa cgacatacga 187861 ttgacaatct gattggcatc gattgcacgt ttggatgcag aggcttctgt ctgtctggcc 187921 ccgaaaaagc atgaaagaaa gagaacggct gaaaggataa gcggaaagac aggtctcata 187981 gaaacttcct cctatcgtct aatcattcac tccatcgctt cataaatcgc ggttatgaca 188041 cttccataac tgcctgttgg aaattggtca ccttcaaaga cgttcggatt ttcttccgga 188101 tcaataactg gtgtatgctt tttatttgtt aacaatgcga tgcctaaatt gtatgctgga 188161 tcaataattg taactgtccc cgtccagccg gtatgcccgt aagcattttc gctggcatga 188221 gggccaaaca tccattccat gcttttactt ccgttccgcc tccagccaag agcgaatgtc 188281 ggatctgttg ctgaaggtgc tgtaaacagg tcggctgttt tctgatcaaa taaagaaatg 188341 tttcggtatg aacctttgtt taacatgact tgcagcagta tggccatatc atctgcattt 188401 gagaacaatc cggcatgccc agacacgccg tccattgagt aaaacgcttt ttcgtcatgc 188461 acctctcctt gcagcgtgtt tgtgcggatg ttagggaatt gaataacgcc gtcacgtgta 188521 ttgcccatgc gttcagtagc tgcgaactgt ttcggtttaa agcccttttg cagcggattg 188581 tacaaggtat gcttcagcct gagcggtttg tagagctctt gctccgtgta gacatcaagc 188641 ggtttgccgg tgagtttttc gacaatacat ccgagtagca tatatccaat gtcactgtat 188701 acgtgttttg tcccggtttg ataatcgagc ggaattttcg tcaaatattc aatcgttttg 188761 tcccgttctt gggaatagta cttgccggct ttttccggcg tgtaaaagta aaagcttgat 188821 gggagccctg attggtgctg gaggacatca atgacacgta tcttgtcttt tccttttatg 188881 aggtcacccg gctgatcctt gaaacccggc aaatatgcag aaactttttc atagacgtca 188941 agttttcctt ggctgactaa gcgctgcaat gcaaaatttg ttgcgtacat ttttgtattt 189001 gaggctaagt caaacatcgt gcgggttttc attttggccg gacggcgcag cagttctgat 189061 ccttcgtact ttttactgta gccgtatgct gcttttttta tgatgcgtcc atccttcacc 189121 accacaagaa cggcgcctgg aaatcctgct gcaatatccc gttctatcat ctgatctacc 189181 ttccttagct tcttcgtcga gaattgtgca gtttctgcat ttatgatttt cggctcaatc 189241 aagttgcctg ctgtttgtgc gaaggtttca tttggcgcaa atatcgatag ggttaaaatg 189301 gcactgaata tgaacagtgt ctttgttttc acaggctagc ccctttctgt gcttctatcc 189361 cgtttactat ccctaaaaca gaaacaattt aatcgaactg agaagccatt tcatctttat 189421 atccgaatgc ataggtcaat aaaaaaccgg ccgcgtagga aataaagagc ccaacgatat 189481 acaggatgat ttgcgaaggc aggactagaa aagatagcgg cagtccggag acaccaatcg 189541 caatggtggc tacttgaaaa taagcttgaa aggcgccgcc gattccagct cctaaacatg 189601 ctgttaaaaa cggacggcca agcggcagcg tgactccgaa aataagcggt tcaccaatgc 189661 cgagcagtcc cgatggaagc ccgccggcga ttgctttcct cagtgttgtt tttttcgtct 189721 tcacgaaaac ggcaaaggcc gcgcctacct gtcctgcacc tcccatagcc aaaataggga 189781 gcagaggatc attgccaatt gaattgatca gttccatgtg cacaggcgtc aagccttgat 189841 gcagtccggt tacgacgaga ggaaggaagg ttgcgcccag aataaagccc gcagcgatgc 189901 cgccgatgtc caggatggac agtaggccgg atgtaatagc atcagaaatg aatccgccta 189961 aaggcataaa tacgacatac gttacgattc cggtgattaa cagtgaaacg gtgggtgtga 190021 caatgatatc aagtgattga ggaataaaac ggcgaataaa ttgttcggtg taagcaatga 190081 atatggctgc gaaaaggacg ccgatcagac ctcccctgcc cgggagaagc tcttctccaa 190141 ataaactgat ttttgcgatc tccggattga taatcaagat cccggccaaa gccccaagtg 190201 cgggtgtccc gccaaattct ttcgaagcgt taataccgac gagaatgccg agataagtga 190261 acagccctga tccgatgact gtcaggataa tcgcaatttg tgagtctgca gagagccagc 190321 ctgcttgaat aattgctttg gtaatcccag taattaaacc ggaagcgact agagcgggaa 190381 taagagggat aaaaatgctg gcaattttac gtaagaaaag tttaaaagga gtggcatttt 190441 tccgattgat atcggctttc tttttggccg ctgcttcttt gacatcggca ccttcttctg 190501 ctgacacgag ctttgagaaa gcagctgtaa catgattgac aactcctgtg ccgaggataa 190561 tttgtaaggt ttcagcttca acgaccccca atacgccgtc aagctttctt aaagcctgag 190621 catccgcttt gctttcatcg taaggcgtaa tgcgcaggcg tgtcatgcaa tgcgtatatg 190681 aagaaatatt ggattttcct ccgcatagct caaggatttt ctgtgcgaga tgatggtagt 190741 tattttcttt gctcattaaa acccctcccc ttcaagatgc cttattttat tctcatagat 190801 tgtatggctg ctctcgtttt atctatataa ccggttgtcg tttcatactg ctcagccgcc 190861 atgcctaaaa acaaaacatc aattataaaa agctgggcga ggcgggaaga agtggctgca 190921 cttcgaatca aggcttcatt ggaatgggct gtatacaaag ggacatcagc cagtgcggag 190981 acggatgtct gactgaattg tgtgaggctg atcgttgtga tgcctttttc cttagccatg 191041 gcgaacagtt caacgatttc ctgtgtctct cctgaaaacg aaatggcgaa tacgatgtcg 191101 tctttatctg catttgcgat taaagatgcc acaagatgag tgtctgtaaa cgcggttgct 191161 tgtttatgaa tgcgaagcca cttttgctgg gcgtccttgg cgacaatgcc ggaagccccg 191221 aggccgataa aatgcacggt atgagctttg agaagcagag aaaccgctcg ttcaagctct 191281 ttgtagtcca tcaggtctga agtatcctga atggcttgaa tggcattgcc ggccgttttt 191341 tcggaaatgg agggcagcgg ctcgtgggga acaatatccc ggtagccctg aaacgtaggc 191401 tttgccagat cgcctgctac tctcattttt aaatcttgaa atccttttaa accgagtgat 191461 ttgcagagcc tgatgacggc agcgtcactt gaattggcta aggcgctgat ttcgttgacc 191521 gtgctttcga ttgctttgtg gggatgggct aggatataat ctgcaagttt gcgctcggat 191581 ggagggagct tatgcttcat tgattggatg atcgctaaac cgcctgtggc cattctagtt 191641 ctctccttat catggatggt aatgttcgat tgctttgtca atgaaaccgt ttgcttcatc 191701 gagtaatgtc tgtgcttgtt tctgatctgt gcttgttttg agcatgacga ttgctgtttt 191761 gacgtgatga tcggcttgtt ccagagtgta tctggctgtg tcgtatgaag cgtttgtaag 191821 gctttggatg atgctgatgg cgcgttcttt tagttttttg ttgctgacgt tgacgtctac 191881 catcaagttt tcgtaaacct tgccgatttt gaccattaca gcggtagata tcatgtttag 191941 aatcatttta tgagcggttg cggctttcat acgtgttgat cctgtaatgg cctcaggtcc 192001 gacgacaacc tcaatgctgt gatccgcatc cttgctgatg gcggaatttt cattgcaagt 192061 aagggcgatg gtgtgtgctc cgactttacg ggcgtatctt agggcgcctg cggcgtaggg 192121 tgtgcggccg cttgctgcga tggcaatgac ggtgtcattt gaagtgagct gtatgtttct 192181 taaatcttca gctcctgctt cttcactgtc ttcaatgccc tctgctgcct gtaaaaaggc 192241 ttcggggcct ccagccatga ttccgatgac ctgatctggg cttacgctgt aggtgggagg 192301 acattcaaca gcatccatga cgccgagtct gccgcttgtg ccggcgcctg tatatatgag 192361 ccggcctcca ttttgaaacg attcatatgc gcagtctaca gctgttttga tgtcggggag 192421 aacctcctga acggctgcag cgactttcat atcttcgttg ttgatcattt taaggatgcc 192481 gagagtgttt gctttgtgga tttcaactgt ttgactattg cgtgattccg ttgtaagacg 192541 gtgaaggttt aatggttctg acatgaggat gccccctgtt ttaaaatgat atatctcaat 192601 attcagtata ttcatttctg ttatgatatt tcaactatgt ttttaaattt ttgaaatttt 192661 atttcactta agactataag aaatgatgaa ggatcaactg ttctccaagc ggcccgattc 192721 ttcgccgtcc tttatcaagg aacccgcttt tcatataaag gtgttttgcg cgtatgttca 192781 gatgattgac ggccaagatg atttcgtcgc accatggaaa atatccgctc acaaaagcgg 192841 gaagcaaaag catggctttt ttcgcatagc cttttccgtg atgcacagcg gttaaagaca 192901 gggagctgag cagtaaagca aatggattgt tagaatagga agcaagcgtt tcttttgatg 192961 catgtaaaat gaaaaaaccg actggaaggt cgtcttttaa gatgacaacc gggtatcggt 193021 cctgtatgcc cagagcctga gacagcacct ctttcgggag ggaggtaaag cgtttgtcat 193081 cgttggtgag cgtgaatgat tggagctcgg gcaagtgttc aggcttatag aaggataaag 193141 aaatgtcttg agtcatgggg tggcctcctt acaatatgtc gttaagctcg ttttccgaaa 193201 tgacgcggta gcccgcttgt tttaacagtg cggcggttac tccgctgccg gtgatttttt 193261 tgccagagaa tgtgccgtta tagataaaac cgcttccgca agatggactg ttttctttta 193321 atatgacggc agaagcgttg atttcttttg cgtaagccaa tgttttcgcg gcgccttcca 193381 tatatagttc tgtgacgtct tctcctgaag ctgtcacgat tttcgctgtt ccattgagga 193441 catcctcgcc agtgcctcct atgatttctg cgggttcgcg tggggtagag aagccgccga 193501 gaagttcagg gcaagccatg actgctttct tttcatcgac tagttttctg attttctccg 193561 acgctgcgtg agagccgtta tatctgcatt caatgcctcc aaggcaagaa ctgactagaa 193621 tcatattggt ttctcctctc ttgctttgct tgtctctatc ataaaataaa tggctttagt 193681 tgggaggctt tttcagttaa aaaaggagtt aaaaagtttg aaaataaaaa atttaatttt 193741 cctctttaca aacagggggt gacctgtata taataacttt tgtcagctcg acgagaacac 193801 aacggcccgt tggtcaagcg gttaagacac cgccctttca cggcggtaac acgggttcga 193861 atcccgtacg ggtcaccatt tggaggatta gctcagctgg gagagcatct gccttacaag 193921 cagagggtcg gcggttcgag cccgtcatcc tccaccatct tgccggtgta gctcaattgg 193981 tagagcaact gacttgtaat cagtaggttg ggggttcaag tcctcttgcc ggcactgttt 194041 tttcaaaatt ttatgtggag gggtagcgaa gtggctaaac gcggcggact gtaaatccgc 194101 tccctcaggg ttcggcagtt cgaatctgcc cccctccacc attattgggc tatagccaag 194161 cggtaaggca acggactttg actccgtcat gcgttggttc gaatccagct agcccagtca 194221 cagacacctt tgatcaaaag gtgtcttttt tcttttcgga aaaatcattc caacttctaa 194281 ctgttcagtc tgtataataa ttttaaaaat atgttaaggt agtttattca cgaattacca 194341 tctacaccct gccaaaaatt tgataaactt attttataaa aaaattgaaa ccttttgaaa 194401 cgaagctcgt atacatacag accggtgaag gcagaggtta gataaatatg gaaatgatga 194461 ttaaaaaaag aattaaacaa gtcaaaaaag gcgaccagga tgcatttgcg gacatcgtag 194521 atatttacaa agataaaatt tatcagcttt gctaccgtat gcttggcaat gtgcatgagg 194581 cggaggatat tgcacaggaa gctttcatca gagcgtacgt taatatcgac agttttgata 194641 ttaaccggaa attttcaact tggctttatc gaatcgcgac caatttgacc attgaccgca 194701 ttcgcaaaaa gaagccggat tattacctcg acgcagaggt ggctggtacg gaaggcttga 194761 ccatgtattc tcaaatcgtc gcagatggtg ttttgcctga agatgcagtt gtatcgctgg 194821 agctctcaaa cacgatacag cagaaaattt taaagcttcc tgacaaatac agaacagtca 194881 tcgtattaaa gtatattgac gaactctcat taattgaaat cggggagatt ctaaacattc 194941 ctgtggggac tgtgaaaacg cggattcaca gaggcagaga ggctcttaga aaacaattaa 195001 gggatcttta agtggggtga tgaaatgagc tgtcctgaac aaattgtgca gcttatgcat 195061 atgcatcttg atggagatat ccttccaaaa gatgaacacg tattaaatga acatctggag 195121 acatgcgaga aatgcagaaa gcatttttac gagatggaga aatccatagc gctcgtacgg 195181 agcacatcgc atgtcgaagc ccccgcggat tttaccgcta atgtcatggc aaaattgcct 195241 aaggagaaga aaagagcttc tgtaaaaaga tggttcagaa cccatcccgt tatcgcagct 195301 gctgcggtat tcatcatttt gatgggcggg ggttttttta acagctggca taatgaccac 195361 aatttcagcg tgtccaagca gccgaatctt gtggttcata accatactgt gaccgtgcca 195421 gaaggtgaga cggtcaaagg tgatgtcact gtcaaaaacg gcaagctgat tattaaaggc 195481 aaaatagacg gggatgtaac cgtcgtaaac ggcgaaaagt atatggcctc tgctggacaa 195541 gtcaccggtc agattgaaga aatcaatcag ttattcgact ggacatggta caagatgaag 195601 tctgcgggga aaagtgtact cgatgcattc aatccgaacg gagaagagta aagcgcgtta 195661 gccgctttgc tctttttttg cgggctgaga gggctggcac atttcacttg ctaaatcgaa 195721 atgtggtata atgggctcgc tatgtaaagt acatatgcgt aacacgtaaa acacaaaata 195781 cgaaatgact gaaatcttgg aggacgagga aatggctttt gaggatatcc cttttttgca 195841 gtacctcggc aatgccgttg atattctcct tgtttggtat gtgatatata aattgattat 195901 ggtgatacgc ggcacgaaag cggttcagct gttaaaagga attgtagtca tcgtgcttgt 195961 tcgtatggcc agccaatatt tgggcctcag cacacttcaa tggctgatgg accaagcgat 196021 aacatgggga tttttagcaa ttattattat ttttcagcct gagctgagaa gagcgcttga 196081 acagctaggc cgcggccgct ttttttcgag gagcggcacg cctgttgaag aagcgcagca 196141 gaaaacgatt gaggccatta caaaagcaat caattatatg gcgaaacgcc gtataggcgc 196201 cctgctgacc attgagcggg atactggaat gggcgattat attgagaccg gcataccact 196261 aaatgccaaa gtcagctctg agctgctgat caatattttt attccaaaca ccccgcttca 196321 tgacggtgcg gtaattatga aaaataatga aattgccgcg gccgcctgtt atctgccgct 196381 ttctgagagc ccgtttattt caaaagaact gggcacgcgg cacagagcag ctgtcggtat 196441 cagtgaagta acagacagtt tgacgattat tgtgtctgaa gagaccggcg gcgtcagtgt 196501 ggcaaagaac ggcgaccttc acagagagct tacagaagaa gcgctgaaag aaatgcttga 196561 agccgagttt aagaaaaaca ccagagacac ttcttctaac cgctggtatt ggaggggcaa 196621 gaaaaatgga taaattctta aacaaccgct gggctgtgaa aattattgct ctgcttttcg 196681 cgctcttgct ttatgtggcg gttaacagca accaagcacc gactccaaaa aaaccgggtg 196741 aatctttctt tccgacatca acaactgatg aagcaactct gactgatatt ccggttaaag 196801 cgtattatga tgatgaaaat tacgtcgtga cgggtgttcc gcaaacggtt aatgtcacga 196861 taaaaggctc gacaagcgcc gtgaaaaagg ctcggcagac caaaaacttt gaaatatatg 196921 ccgatatgga acatttgaaa accggcacac ataaggttga gcttaaggcc aaaaacgtgt 196981 cggatgggct gacaatctca attaatccgt ctgttacgac agtgaccatt caggaacgga 197041 cgaccaaaag ttttcccgta gaagtggagt actacaacaa aagcaagatg aaaaaaggct 197101 attctccgga gcagccgatt gtcagtccga aaaatgtgca gattaccgga tcgaaaaatg 197161 tgatcgataa tatttctctt gtaaaagctt cagtgaattt ggaaaacgca gatgaaacga 197221 ttgaaaagga agcgaaagtg actgtctatg ataaagacgg aaacgcgctt cctgtcgacg 197281 tggagccctc ggtcatcaag attaccgttc cggtgacaag cccgagtaaa aaagtgccct 197341 ttaaaattga acggacagga agccttcctg acggtgtcag catagcgaat attgaatcca 197401 gccccagtga ggtaacggtt tacggctcac aggatgtgtt ggattctctt gaatttattg 197461 acggcgtcag cctagattta agtaaaatta acaaggattc cgatatcgag gcagatattc 197521 cgcttcctga cggtgtcaaa aaaatctcac cgtcaaaggt gactttgcat atagaagtcg 197581 atagtgaagc ggatcagaag ttcgagaatg tccctatcaa gactgtaggg ctgagcagct 197641 cacaaaacat tgaatttctt gatcctgaat cacaagcgat agatgtaacg gctaaaggct 197701 ctcccacgaa tataaataaa ctgaaaaaat cagatattga attgtatgtg aatgtttcag 197761 atttagagga cggggagcat agcgtgaagc ttgaagtgaa cgggccacag aatgtaactt 197821 ggtccttggg gcggaaaaac gccaaaatca agctgacgtc taagaaaagc aatacatcaa 197881 cgaatgataa cagcagcaat acatcaggga accaggacac agataaacaa acaaatgatc 197941 aaaagaacaa tcagcaagaa gatacaaaga acactgataa aaacaacaac gatcaaaacc 198001 aagacggaaa taaagatcaa aaccaagatc aggatgagga tgaatccact gcgaattcac 198061 aatcctcatc ggaataaaaa aggagcgatt ataaaatggg caagtatttt ggaacagacg 198121 gtgtaagagg tgtcgccaat agtgagctta cacctgagct ggcctttaaa gtcggacgtt 198181 tcggcggtta tgtgctgaca aaagacaaac aacgtccaaa agtgctgata ggccgcgata 198241 cacgcatctc cggccatatg ctggagggag cccttgtcgc cggactttta tccattggcg 198301 cagaagtcat gcgcctgggt gtcatttcta caccaggtgt atcttatttg acaaaagcga 198361 tggatgcaga ggcgggcgtc atgatttccg cttctcataa cccagtgcag gataacggca 198421 tcaaattctt tgggggagat ggatttaagc tttctgatga acaggaggct gaaattgagc 198481 gcctgatgga cgaacctgag gataagctgc caagacctgt cggagcagac cttggacttg 198541 taaacgatta ttttgaaggc ggacaaaaat atctgcaatt cttaaaacag acagctgatg 198601 aagatttcac aggcattcat gtggcattgg actgtgccaa tggcgcaacg tcatccttgg 198661 cgacacacct gtttgctgat ttagatgcag atgtttctac aatggggact tccccgaacg 198721 gattaaacat taatgacggc gtcggttcga ctcatcccga agcgctcagc gcgtttgtca 198781 aagagaaaaa cgcggatctc ggtcttgcgt tcgacggtga cggcgaccgc ctgattgctg 198841 tcgatgaaaa aggaaatatt gtagacggcg accaaatcat gtacatatgc tcaaaacatc 198901 tgaaatcaga gggccgttta aaggatgata cagtggtttc aaccgtgatg agcaacctcg 198961 gcttctataa ggcgctcgaa aaagaaggca tcaaaagcgt gcagacagct gtcggcgacc 199021 gctacgtagt agaagcaatg aaaaaagacg gctacaacgt cggcggagag cagtcaggac 199081 atcttatttt ccttgattac aacacgacag gggacggatt attgtctgct attatgctga 199141 tgaacacttt aaaagcaaca ggcaagccgc tgtcagagct tgcagctgaa atgcagaagt 199201 tcccgcagct gttagtcaat gtgagagtga ctgataaata taaagttgaa gaaaatgaaa 199261 aagtaaaagc agttatttct gaagttgaaa aagaaatgaa cggcgacggc cggattttgg 199321 tgcgcccttc aggaactgaa ccgctcgtcc gtgtcatggc tgaagcgaag acgaaagagc 199381 tgtgcgatga gtatgtcaat cgcattgttg aagtcgtccg gtcagaaatg ggattagagt 199441 aacgaagtct attatcagag agtgaacaag acaagcgagg tttacataag ataattgtga 199501 gacatacggc aaagttgctt aaaaaacaat tgaccgttta tgccacatgt tgtaaaatca 199561 agcttgtctt gttcttattt tctcaatagg aaaagaagac gggattattg ctttacctat 199621 aattatagcg cccgaactaa gcgcccggaa aaaggcttag ttgacgagga tggaggttat 199681 cgaattttcg gcggatgcct cccggctgag tgtgcagatc acagccgtaa ggatttcttc 199741 aaaccaaggg ggtgactcct tgaacaaaga gaaatcacat gatcttccaa aaaacatgta 199801 ggaggggacg attgaaagtc cccttgaaat ttgactttct tcgtctcctt ttacaatctt 199861 aggaggaaga aaaatatgtg tggaatcgta ggttatatcg gtcagcttga tgcgaaggaa 199921 attttattaa aagggttaga gaagcttgag tatcgcggtt atgactctgc tggtattgct 199981 gttgccaacg aacagggaat ccatgtgttc aaagaaaaag gacgcattgc agatcttcgt 200041 gaagttgtgg atgccaatgt agaagcgaaa gccggaattg ggcatactcg ctgggcgaca 200101 cacggcgaac caagctatct gaacgctcac ccgcatcaaa gcgcactggg ccgctttaca 200161 cttgttcaca acggcgtgat cgagaactat gttcagctga agcaagagta tttgcaagat 200221 gtagagctca aaagtgacac cgatacagaa gtagtcgttc aagtaatcga gcaattcgtc 200281 aatggaggac ttgagacaga agaagcgttc cgcaaaacac ttacactgtt aaaaggctct 200341 tatgcaattg ctttattcga taacgacaac agagaaacga tttttgtagc gaaaaacaaa 200401 agccctctat tagtaggtct tggagataca ttcaacgtcg tagcatctga tgcgatggcg 200461 atgcttcaag taaccaacga atacgtagag ctgatggata aagaaatggt tatcgtcact 200521 gatgaccaag ttgtcatcaa aaaccttgat ggtgacgtga ttacacgtgc gtcttatatt 200581 gctgagcttg atgccagtga tatcgaaaaa ggcacgtacc ctcactacat gttgaaagaa 200641 acggatgagc agcctgttgt tatgcgcaaa atcatccaaa cgtatcaaga tgaaaacggc 200701 aagctgtctg tgcctggcga tatcgctgcc gctgtagcgg aagcggaccg catctatatc 200761 attggctgcg gaacaagcta ccatgcagga cttgtcggta aacaatatat tgaaatgtgg 200821 gcaaacgtgc cggttgaagt gcatgtagcg agtgaattct cctacaacat gccgcttctg 200881 tctaagaaac cgctcttcat tttcctttct caaagcggag aaacagcaga cagccgcgcg 200941 gtactcgttc aagtcaaagc gctcggacac aaagccctga caatcacaaa cgtacctgga 201001 tcaacgcttt ctcgtgaagc tgactataca ttgctgcttc atgcaggccc tgagatcgct 201061 gttgcgtcaa cgaaagcata cactgcacaa atcgcagttc tggcggttct tgcttctgtg 201121 gctgctgaca aaaatggcat caatatcgga tttgacctcg tcaaagaact cggtatcgct 201181 gcaaacgcaa tggaagctct atgcgaccag aaagacgaaa tggaaatgat cgctcgtgaa 201241 tacctgactg tatccagaaa tgctttcttc atcggacgcg gccttgacta cttcgtatgt 201301 gtcgaaggcg cactgaagct gaaagagatt tcttacatcc aggcagaagg ttttgccggc 201361 ggtgagctaa agcacggaac gattgccttg atcgaacaag gaacaccagt attcgcactg 201421 gcaactcaag agcatgtaaa cctaagcatc cgcggaaacg tcaaagaagt tgctgctcgc 201481 ggagcaaaca catgcatcat ctcactgaaa ggcctagacg atgcggatga cagattcgta 201541 ttgccggaag taaacccagc gcttgctccg ttggtatctg ttgttccatt gcagctgatc 201601 gcttactatg ctgcactgca tcgcggctgt gatgtggata aacctcgtaa ccttgcgaag 201661 agtgttactg tggagtaata attaattaac ccctttggat aagaaggtct tcacatgtgc 201721 tgctaggctc caaatgtaca cctttccgta agggcaaagt caaatgtgaa aaaaaactgt 201781 tccaaagtta atcagaaatt tattttcata ttgtatcctt cggtatcaag tgaaaggagc 201841 atcatatgaa aacattatgg aaagtcctca aaattgtttt tgtcagcttg gctgctttgg 201901 ttttgcttgt atccgtctcg gtatttattt atcaccattt ccagctaaat aaggaggcgg 201961 cactgctgaa aggtaaaggc acagtagtcg atgttgacgg taaaaagatg aatgtgtatc 202021 aagagggaag cgggaaggat acgtttgtgt ttatgtccgg ttcgggtatt gctgcgcctg 202081 cttatgaaat gaaggggctg tacagcaagt tttcaaaaga aaataagatt gctgttgtag 202141 atcgggcagg ttatggatac agtgaagtgt ctcacgatga cagagatatt gatacggtat 202201 tggaacagac gaggaaagcg cttatgaaaa gcggaaataa gcctccttat attttaatgc 202261 ctcattcgat atccgggatt gaagcgatgt attgggcaca gaaatatcct aaggaaatca 202321 aggccattat tgcgatggat attggattgc cccagcagta cgtcacgtat aaattgagcg 202381 gagttgaccg attgaaagtg agagggttcc acctgttaac ctcgattggt tttcatcggt 202441 ttataccttc cgctgtatat aatcctgagg tgattcgaca gtcgttttta actgatgaag 202501 aaaaagaaat ctataaagcc attaacttta agcaattttt taatgcagat atggagcatg 202561 agcttttaca gtcttaccaa aacggcagca aatctgtgaa tctgcctgcg ccaaaggaaa 202621 ctcccgtctt gattttagat gcagtctctg accaaaatag acattcaaag tatgctatac 202681 aaaaccgaaa agactatgaa gcgtttgcgg ctcaattcaa tactgccgat ataaaggaac 202741 tgaggggaac acacagtatt tatttatatc agcctgatca aatatataaa ctgtccatgg 202801 agtttatgag aaaggttcgc taggatgaag ggttatcgta ttttaatcgt tgaggacgat 202861 gtgatgattg gtgatttgct gcaaaagatt ttgcagcgcg agggatatcg tgtgatatgg 202921 aaaacagatg gagcggatgt gctttcggtg attcagaagg tggatttggt cattatggat 202981 gtgatgctgc cgggtgaaga cgggtatcaa atgtctgcaa aaatcaaaaa gctggggctg 203041 ggcattccgg ttatttttct ctcagcccgc aatgacatgg acagcaagct tcaaggtttg 203101 cagatcggcg aggattatat ggtaaagccc tttgatccga gagagctgct attaagaatg 203161 cggaatatgc ttgagcatca ttatgggacc tttacgcaaa tcaaacattt gtatattgat 203221 gcggtaacga aaaaagtgtt caatgaaagc ctgcatgatg aggtattatt tactgcgatt 203281 gagcggaaaa ttttctttta tttatatgaa aatagagaca gtatcctgac aaaggaacat 203341 ttctttgaat atctatggca gctcgaagat agaaacccga atattgtcaa tgtgcatatt 203401 aaaaaaatta gagctaaaat caatgatcaa gcgggtgaga tgattgaaaa tatatatgga 203461 gaagggtatc ggctgaatac cgttgtgaag aaatgaagct caagacaaaa tatcagttgt 203521 tattgtttac ggccgtcatt agtgttccga tgctattgct ggcggtcagt gttttgatgt 203581 cggtgattta tgacagcatg tttaaaccga tgaatcatgg tatgcccttt cacaggtcgt 203641 ttgcataccc ggcaatgatc gttgtatttt tgatatcact cttattgtta gcttttttat 203701 tttcaaagtc gattcattct ctgttgcata aaatcaatct attaaatcaa accattcggc 203761 atttggcgag tgatcaaagg gtgcccgata aaattgaagt gaagcgtgct gatgaaatcg 203821 gggaactgat caagtcggtc aatttgttaa ttgaacggac gacatatcgt gaactggagc 203881 tgagacagca ggaggaaatc aaaaaggagc ttttgcaaaa actgcggcat gacattaata 203941 cacctttaac ggctctcagg ctgcagttat tttatttgga agaccaatgt catggtcagg 204001 ctgtattcga atcattgtat cagcaaatcg aatatatctc ggaattaact aatgaattca 204061 atctatattc cgctgagacg ctggaaagct cttatattgt aaatgaagaa gtgcgtctaa 204121 acgagctatt agaaacagcg gtgaaaaagt gggattattt atacagtatg agtgggattg 204181 agctgcacta taagccggca gatcaagatg tgatatggat gagcaacacg ttatggatgg 204241 aaaggctgtt tgataatatt tttcaaaata cgttaaggca ttcaaaagct aaaaagatgg 204301 aagtcacgat tgaacatggc gatgttttta ttcgtgatga cggtattgga tttgatcgga 204361 atgagagcag tgagggactt gggttaaaga ttattgagga tacatgcagg ctgcttgcga 204421 ttacttatga gctgcataca aatgataacg gaacggggtt cttgttttca aaagagtgac 204481 cccgctgatg tttttctttc tcctataaaa tttatataat agggagaaag aaatggggtg 204541 aacatcatat gtttaaaaaa atcatcaaaa cgattaagta cctctcaagc agttctagtg 204601 accgatatcg cagacaccgg cattacagca gcagccggcg cagacattat cgcagctaca 204661 gcagcagttc gggcaaaaga agacactacg accgttatgg cggcagtcat cgttacaaac 204721 gccggagcta cagcagcagt taatccaaaa aaagttcttg ttccgctttt gggacaaggg 204781 tttttttatg tgaccgattg aatggcccgg tttagatcct cgcgaatgga agcggtgtgc 204841 tgatactctt cctcaatgcc caataatctt ttcagcagca aggttacttc ctttgtcagt 204901 gttaattcct ccagccaagt gccgtttttc ttcttttttc ctttatattg agagtacagc 204961 aagaataaca gcgtttctcc gagatcgaag aagtcatcct gttttcgtac ctttatttcc 205021 tccatttctt caggagtcaa ttgtttggca aggccgaaat cgatgaggca gagcctgcca 205081 tcattgatga tgatattagg cgttctgatg tcgctgtgga agataaggcg atcatgcagg 205141 tattctataa tctcaagcag ctgcgaaatc agttgtaacg ccataagctc tgtgaacggc 205201 tgttttcgaa aaaataataa ttcttctata ttctctccct caatgaactg catgacataa 205261 taagcctgtc cgtctatgat gaattcatct atgaagcccg gaatttgcgg gtggtgaatg 205321 tttttgagca gttttatttc ctgctggaat cggactttct ctttttcctt tttggctttt 205381 gtcggccgaa gctgttttaa gacataaggt gtttgagcta ggatatcggt gcacaaataa 205441 accaaaccgt agcctcccat accgaggcac tcttcgattt tgtattgatg atttaagata 205501 acgccgttct ttagagggcg gtcaaatagc agttttttta gaagttttaa tgccatgtct 205561 gcacttccct tggttgtact gactatagtt taccttctag acggagaata aaaaagagcc 205621 ggataaccgg ctcggtataa gttaaaactg ctttgtcacg tcgtattcat aatctatttt 205681 tgcttttacg ttgctcatcg tcgatctggc tgtcgctaat gtattatatt taaaactcca 205741 tacctttgcc acactgagtt gatccgacaa agagatatca taagaccctg aagtcgagct 205801 gtttacaagg gcacggctcc attcgttatt ttcgcttgtc atgatcagat ggcgtgtatt 205861 tccctggctt ggtgtttgag tggcggttgt ttgaactctg gttacaatgg catcacgcgg 205921 tatcccagat tggtttgtta aatcaacctt gatcacgctg gagtcagaac ctgaggggct 205981 aaggcttgta tttcctttat tttcagcaac gccgctgaat tggaacgttc cgctgcctga 206041 tttgattcgg tcttcaattg aaagcgtaaa gtacatgttt ccagtatagg tgcctcgtga 206101 cactttcaca tagaaggtat ccgtcgtgtt ttgggcgtct gcatttgcat aaataaaaga 206161 agaaaacgta ttagggttaa taacttctgt cccttgagaa acaggtattc tgttcttgtc 206221 ataaatttca attttcatcc ctgtatacgc gctctggtat gtactcctca tgtatacttt 206281 ttctccctta ttagccgtaa aagtgaaata ggcttcatct tgaccagctt ccagtattgt 206341 tgtatcgata tttttatatt tccaataacc gatcggcatt gcggtatcaa atgaattgtt 206401 tcctgtgata gcagtgactc cgacagctga tgccgaatac gtaaaggtag ataagacaga 206461 aagcataaca gcgaattgaa taagccattt tttcaccatg caaacaacct ccttttattt 206521 ccatcataca taataacgat ttaggtgtaa ataaatgttt tttgaggtta atatatacat 206581 tatattcgcc gataaaaaag aataagagag aatactcggg agggaattca atgcgtctga 206641 atcggcaatt tatccgcact cagctgattg cacagaacat attgagcaag aatgcgcctg 206701 ccaaacggga gaatgcgact gaaaatccag cggcagttct ggaaaaggca tatagcaggc 206761 ttaagtcaca atcttcaact gggggaatca atcagttcaa ttattctaaa accagcgtgt 206821 cgggaaacag cgggacgttc agcaaagtgt atcaatcagc gaatgatcga acagtgacag 206881 acacagggga agaaacagtg attcaatccc aaaaccccta tgaatctgag agtgatatca 206941 gaatcaaaat actagatgaa aaatacagca ggatgaatgc gattaataaa acaaagtctg 207001 atccattagg ctatattaag gataagtacc aaaattcaaa gtctccttat ttcagaagtg 207061 atctgtcagc tgcagaaaga caggccgctt acgataatga aacagaatgg ttattcaaag 207121 ggaaggcgca aaactataac cttcaggatg ctgtgtttcg gaatgtcaca tttcatgggg 207181 aagtggaagc tgagaatgaa aaggtgtatc agcggggaca ggttaaccag cagctgcaag 207241 tactgttgaa tcgaaaccat attcatattc cagaggggac agagctgacg tttacaatca 207301 caccgattga ctatcaggtg cgggtaagcg ggacagacga tcaggatctg atcaagcaaa 207361 ttgagcaagt gctgcaatct ggagacaaca gcaaagaact atttttacac atcatgaaaa 207421 gtcaaagcag tgattcagca caattttccg aagaggccta taaaaagtat caggcagctc 207481 gtgagatgta tgaagttaca ggctaccatt tgaaggattt agaagtgatt gatgggcggt 207541 acgtcacgcc tgagggacgt gacttaatgg atgtatataa ggaagagctt gaaaaagatc 207601 cagtgcagaa acaaacggct tcttatgcta tatcttacta tcgttcagag ctcagtaaaa 207661 tcgcggaagc cgggtataat gccattccgg atttcatcct atcaattgat tacagcaatg 207721 gatctctgag agatgtggga caaagcaaga gctatgggac cggagatacc gggtggcttg 207781 aagcattaaa gcgtcaaacg ggtgtgaatt attaggtaag ctgttcatgt aggacagctt 207841 attttttatg agaatctaag gggtgaatta atcccaatat tcaaataatt ttattatttt 207901 tatataaaag attttaaaag aagtgaacga ttcaaaactc tgaacaaagg tgtttacctg 207961 aaaaaaacaa ttgtattttc cagagaaatt tattatgatg aaataagtaa tttaggagat 208021 tatataacaa ttttaagttt gaattttctg attgttatca ctgattcatg tgaaggcaag 208081 caggtctgct gttttctcat ttatgagtat tttgttagga ggaggaagag gagtggcaaa 208141 taaagaatta aagaggggcc tgggcgcgcg ccatattcag atgatcgcct tgggcggtac 208201 aatcggtgtt ggcttgttta tgggttctgc cagcacgatt tcatggactg gcccatctgt 208261 ccttctggct tatgcaatat gcggaatttt tatctttttt attatgcgtg cgatgggtga 208321 aatgctgtat gtcgagccga gcacaggttc ttttgcgacg ttcggccatc aatatattca 208381 tccgatggca ggttatataa cagcatggag caactggttc cagtggatta tcgtcggcat 208441 gtcagaaatt atcgctgtcg gttcttatac gaagtattgg ttcccggatt tgcctgcttg 208501 gatacctggt atcgtggcaa tggtgattct tggtgcggcg aatttaattt ctgttaagtc 208561 gtttggggaa tttgagtttt ggtttgcgat gattaaaatc gtgacgatta tcttgatgat 208621 tattgcggga atcggaatta ttttcttcgg ttttggcaat ggcggagatg cgatcggttt 208681 gtcgaacctg tggtctcacg ggggcttctt tgcaggaggt ttctcaggtt tcttctttgc 208741 actgtctctt gtcattgcag cctatcaagg agttgagctg atcgggatta cagcgggtga 208801 agcgaaggac ccgcaaaaca cgctaagaaa tgcgattcaa agtattatct ggcgtatttt 208861 gattttctac attggcgcta tttttgtgat cgtgacggtg tatccttggg atgagctcaa 208921 ctcactcgga agtccgtttg tgtctacgtt ctcgaaaatt ggaattacgg cagcggccgg 208981 cattattaac tttgtcgtga ttactgcggc aatgtccggc tgtaacagcg gtattttcag 209041 cgcgggccgc atgctgtata cactgggtgt caatggacaa gcaccgaaat tctttaagaa 209101 gatttcacgc aatggtgtgc cgctgtatgg cacaattgcg gtgctgatcg gtttggctgt 209161 cggcgttgta ctgaactata tcgcgccgcc gaagatcttt gtctatgtat acagcgcaag 209221 cgtgctccca gggatgattc cttggtttat cattttgatc agccatatcg gattcagaaa 209281 agcgaagggt gctgcattag ataaacatcc attcaaaatg ccgtttgctc cttttacaaa 209341 ctatttgacg attgctttct tgctgatggt tctggttggc atgtggttta acgatgatac 209401 tcgtatctcc ctgattgtag gcgtgatttt cttagcgctt gtggtcatta gttattatgt 209461 gtttgggatt ggcaaacgca cgcaggccaa tttgacaaaa agcgaacaag cagctgaata 209521 acgataaaaa agagacattc acggatgtct ctttttttat ttttcgcgta tggattttcc 209581 ctattttagc aagctatagg gtaaagatag cagaaggaaa ggtgttcata aaatggatgt 209641 tacactcggt tatttgcgcg aatcactttc gaatcatcta gaaaatgaag tctgccagcg 209701 tatttgcaag aagatgctgg cgaagcgtta tgcaaatgaa gaggaatttg taaaagactt 209761 agatgataat gaaatgtctt ttttgaacca tgtattagaa aaagaaatta agtatgccca 209821 gaatgaacag gatcaaaaac gggccaagga attaaacgag gtgtatgaat tactgctttg 209881 agaaaggcgg gtaagaaatg ggagcaattg aacgaagcgg atatacattt cagccggagt 209941 ttagcgttgt ccgtcaaaac ggagccatcc atgtgtacca tcaaggagaa tttgtggaag 210001 aaatcgaatt tgaatttaac ggggaatatc ccgatcatga tttgattgaa gagcttgtga 210061 atcattattg ttttgagcat gagatttaga gccctgccgt gcagggctct tttatttagg 210121 atgtaatcag gccatacttt ttcaggatat ccacggtgat gtttttggct tttgtgccgg 210181 aatcatcgac attggtgaca aagacataag agccatgctc tgttttgatg aatccgacaa 210241 accatcctaa tcccatatca gtcaggcggg ttccggtttt cccgtagagc gtgtaatgat 210301 cgccttcctc ttgaatcatc atgcgcttga cgattttcat caccggcttg tcaaatggaa 210361 gctcctcttt agccagtttc tccaaaaaag tttcttgttc cagcggagat attgtgagcg 210421 agctttgcag ccaaaactgg tcgattcccc cgctgatatc ctcgttgccg taagatagag 210481 tatgaagcca tgttttcatt ctttcctcgc cgatatctct cgctaatgcc tgataatacc 210541 agattgcgga ttcgcgcatg gccgagccaa gcgtatggtc gcggttccat gattcgaatt 210601 cacgcttgac cccgtcccat cgtttaacat cgtattcatc tcttacagct ttgacctgca 210661 aaccgattaa agcgttcacg actttaaagg tggattgcgg agtttgtctt tgatttgccc 210721 gttttctgtt atagacaaat gtctgatcct tttgtaaatc gtgaagaatg aaggttccat 210781 ccgtatcctt gaattcatca tcgacattca ttttgctgac attcaagtgt ttttcatgag 210841 cagatgatgc tgcgtggacg gagaagccgc cgatccctgc aatactcagc acaagcacaa 210901 catatatcca ttttttcatt ttgttctccc cttcgttttg attaactacc ttttctctct 210961 ttcgtttgtt cttcctttaa aaaataatca aaaagcgctt aaatttggtt ttgcaaacaa 211021 atactgttac tgggtttata gtcggaagat aacgtgaaaa tagagggtaa aaaggaaggc 211081 agggtaagcg gatgaatgag cagattccac atgacaaaag tctcgataac agtctgacac 211141 tgctgaagga agggtattta tttattaaaa acagaacaga gcgctacaat tcagatctgt 211201 ttcaggcccg tttgttggga aaaaacttta tttgcatgac tggcgctgag gcggcgaagg 211261 tgttttatga tacggatcga ttccagcggc agaacgcttt gcctaagcgg gtgcagaaat 211321 cgctgtttgg tgttaatgcg attcagggaa tggatggcag cgcgcatatc catcggaaga 211381 tgctttttct gtcattgatg acaccgccgc atcaaaaacg tttggctgag ttgatgacag 211441 aggagtggaa agcagcagtc acaagatggg agaaggcaga tgaggttgtg ttatttgaag 211501 aagcaaaaga aatcctgtgc cgggtagcgt gctattgggc aggtgttccg ttgaaggaaa 211561 cggaagtcaa agagagagcg gatgacttca ttgacatggt cgacgcgttc ggtgctgtgg 211621 gaccgcggca ttggaaagga agaagagcaa ggccgcgtgc ggaagagtgg attgaagtca 211681 tgattgaaga tgctcgtgcc ggcttgctga aaacgacttc cggaacagcg ctgcatgaaa 211741 tggcttttca cacacaagaa gatggaagcc agctggattc ccgcatggca gccattgagc 211801 tgattaatgt actgcggcct attgtcgcca tttcttactt tctggtgttt tcagctttgg 211861 cgcttcatga gcatccgaag tataaggaat ggctgcggtc tggaaacagc cgggaaagag 211921 aaatgtttgt gcaggaggtc cgcagatatt atccgttcgg cccgttttta ggggcgcttg 211981 tcaaaaaaga ttttgtatgg aataactgtg agtttaagaa gggcacatcg gtgctgcttg 212041 atttatatgg aacgaaccac gaccctcgtc tatgggatca tcccgatgaa ttccggccgg 212101 aacgatttgc ggagcgggaa gaaaatctgt ttgatatgat tcctcaaggc ggggggcacg 212161 ccgagaaagg ccaccgctgt ccaggggaag gcattacaat tgaagtcatg aaagcgagcc 212221 tggatttcct cgtccatcag attgaatacg atgttccgga acaatcactg cattacagtc 212281 tcgccagaat gccatcattg cctgaaagcg gcttcgtaat gagcggaatc agacgaaaaa 212341 gttaaattaa aaagctctct tcctttatcg aagagagctt tttgattact tctttttttc 212401 atcgtagtat tggacgggat acatggagcc ttctgatacc attttgttgt cctcgatatc 212461 ttgcgggtcc gggtggccgg ctttatcaac tgggaacgtt tccatgtctg gctgttttgt 212521 tattttcatc ttcatgctgt gaatgaattc tcttgccttt tggcgatttg acgggtcttt 212581 taatagataa gaagtgatgc cgacagttga aacagcgaga cctgaaagta acagcttttg 212641 tttcatggtg atactccttt ctattttaag aatagtgttt cctgtatcat tcccgttttg 212701 gaaattgcta aacctgttgt gtttttatca ttggaattaa cagtaaattc catttaagaa 212761 gaaactagtg acttcattcc tgtattggaa ggtaatatac attgacttat tatagatttc 212821 agtcaaaatt cgataaatat tgacaaagta aagtaatcag aataataata taattagcaa 212881 gagaatgtca tcatacatga aaggtgttta cgatatgaat caattgcatc gaagaatggg 212941 aacgttttcc ctcatgatgg tcgggctcgg gtcgatgatc ggttcaggct ggctgttcgg 213001 ggcttggcgt gcggctcaaa tagcaggacc agctgctatt atttcatggg ttattggaat 213061 ggtcgtcatt ttatttattg ctctttctta tagtgaacta ggttctatgt tccctgaagc 213121 ggggggaatg gtcaaataca cgcaatattc acacggttcg tttatcggtt ttattgcggg 213181 ctgggccaac tggattgcga ttgtgtccgt cattccggtt gaagcggtgg cctccgttca 213241 atatatgagt tcttggcctt gggaatgggc gaaatggaca agcggtttgg tgaagaatgg 213301 aacgctgact ggggaaggac tagcgtttgc ctctgtattg cttctcattt attttctgct 213361 gaactactgg acagtcaatc tattttcgaa agcgaattca ttaattacga tttttaaaat 213421 tattattccg ggtcttacga ttggagcttt gctgtttgtc ggattccacg gagaaaactt 213481 tactggcggt caaagcattg cgccgaatgg ctgggcaagt gtgctgacgg cggttgccac 213541 ttccggtatc gtttttgcgt ttaatggttt ccaaagcccg attaatatgg cgggtgaagc 213601 aaaaaatccg gggaaatcaa tcccgattgc ggttgttggc tctctttttg ttgcgacagt 213661 gatttatgtc ctgctgcaga tcgccttcat tggagctgtg aatccttctg atattgctca 213721 cggctggagc catctgaatt ttaattctcc ttttgctgat ctggcgattg cgctgaatat 213781 taactggctt gttattgtgt tatatgcaga tgcatttgta tcaccgtctg gaacggggat 213841 tacgtatacg gcgacaacgt cccgaatgat ttacggaatg gaaaaaaaca aatacatgcc 213901 gagtatattc gggaagcttc atccgattta cggcgttccg cgacaagcaa tgttctttaa 213961 cttgattgtt tcgttcatct ttttgttcct gttcagagga tggggcgtat tagcggaaat 214021 tatttctgtt gctacgttaa tttcttatat caccggcccg atcacagtga tgacattgag 214081 acggacgggg aaagacctgt acaggcctct tcgtttaaaa ggcttaaatg tgattgctcc 214141 gcttggattt atctttgcgt cactggtgct gtattgggcg cgctggccgt taacaggaca 214201 ggttctgttt attatcctga tcggtcttcc gatttatttc tattatcagg cgaaggcgaa 214261 atggaaaggg tttggccgga actttaaagc cggcgtctgg atggtgtttt atctgctggc 214321 catgatggtt atttcttatt tgggcagtga taaattcggc ggcctgaatg tcattcatta 214381 tggctgggat atggttctga ttgcgatggt atcccttgta ttctatgtgt gggcgctgaa 214441 gagcggctac cagacagaat acttaaagga tgcgaaagag ataaattctc agctgcttaa 214501 tggacagtca gaagctgctg ccggaaaaga ataaaatata gaagaaaacc ttgcgatagt 214561 tgtcgcaagg ttttttgctt ttaataaccc ttttttactt tgtggaaaag atcaggatag 214621 ttggtgaaca ctcctgttac gccccaatca agcaggcgat gcatatcagc ttcattattg 214681 actgtgtaag gatgaagcag gaggccgtgg ctgcggatca tacggacgtt ttcttgattt 214741 aaagctttat aatccgggcc cgcaccgaca gcgtatgttt tgatttcttc cagggcagca 214801 tctgtcattg acgccatttg tttggcttcc agcaattgaa cggtcggcag gtttggctgt 214861 aattgatgga cttttaccag gctttctttg ctgaacgatt gaatgatcac ctggcctggc 214921 ttagaatgct ttcccagtaa tttatgtttc tgcaaagaag cgatcagttt ttcttccata 214981 cctgggtagg tgtcaggcga ttttgtttca atgtagtagt tcgcgtgctt tccgaaacgg 215041 tctaatacct cttctaatgt aggaacttta aggccgacgt actgcggctt tgctttttcc 215101 ggataggctt cattaaacca agaaccggcg tcaagcttct taatgtctgc gagcgtatgg 215161 tctttcaccc aacccattcc gtttgtggtg cggtccagtt tttcgtcatg catgacaatc 215221 aattttccgt cttttgtcat ttgcagatcc aattcaataa aatcagcttt cattttctga 215281 gcggtttcgt aagacagaat cgtgtgctca ggcacatatc cagaagcccc tctgtgcgcg 215341 acggtcagga tacggtcagg tgacagcagg tttccttttg acgctgccga cactggcgtt 215401 accataaatg agagtaagcc cagcgacaga acaaacaagg ccagtattct attttttctc 215461 atgatttctc ctccttatag ataagcacta cctgtctttc ataataaaaa acggatgtaa 215521 acggcgtgtt ggaaaactat taatctttta tgtgtctttc ttaaacatgc tctgcccgtt 215581 ttcctgtatt ccacgtcaaa gccaagaaga cgatggcaag aatgcaggat gagatcagca 215641 tgataaagcc gccgttccag ttaaaacggt ccacgacaaa gcccataatg gcgtttgcga 215701 aggcggatcc gccgatgtat ccgaaaaatc cggtcaaacc ggctgcagtt ccggctgctt 215761 ttttcggtgc taggtcaatt gcttgaaggc cgatcagcat aacaggtccg tagattaaga 215821 agccaatgct gatcagggcg atattgtcca cgagcggatt gccggccgga ttcagccagt 215881 acaccaatac ggcaatgaaa acacccgcca taaacaaaac gcctgccggt gcccggcggc 215941 ttttgaagaa tcggtcactg atccagccgc acaagatcgt tcccggtatg cctgcgtatt 216001 cgtaaagaaa atacgaccag cgtgagtctt caggagaaaa gcctttggct tctgttaagt 216061 aagtaggcgc ccagtcaacc acgccgtatc gcacgaaata aacaaataca ttggcaaaag 216121 cgatgtacca aagaaatttg ttgttcagca catattgaaa aagaatttct tttgttgtta 216181 attctttttc ctgattttta aaagcgtgtt ttggatagtc attccgatac tcttcaattg 216241 gcgggagtcc gcaggattga ggcgtatcac gaaccaataa aacaattaaa aatgaaatga 216301 taatggcgat gatggcaggg aagaaaaaca cgcttttcca agtgacgaac atcgcgatcc 216361 caagagtgac aagcggagca agaataccgc cgcctatgtt atgggcgaca ttccagatcg 216421 acatttttgt gccgcgttca cttatggaga accaatgggc catcgtcctg ccgcatggcg 216481 gccagcccat tccttgaaac catccgttga taaacataaa aataaacatg atggtgacgc 216541 tcgaagtcac ccaaggcatt gaaacgaata gaatattaac gattgctgat aaaaataggc 216601 ctgtcgccag aaaatatctc ggattacagc ggtcagacac cattcccatg atgaatttgc 216661 tgaagccgta cgcaatggac acagcggcca gcaccaaacc cagttctgtt ttcgaaaatc 216721 cctgttcctg cagataagga atggcaaagg caaagttttt ccgcagcagg tagtagcctg 216781 cgtagccaat gaaaatacca atgaatactt gcagtctgag ccgtttgtat gccgcatcca 216841 tctttgaatc atccagtctc tcaatatgag gagccggttt aaatatatta agcattaata 216901 attatccccc tttgctgttt gtgctggatg tgtggcgtgc ctcctttccc gaaaaacaaa 216961 aagagccaga aaacacccct tgtcaaaagg ggttggattc ctggctctcc tcatctccat 217021 ccaagctatt aacttatcat gatagcgctt tcttaaatta tcatagtccg gagcgaatgt 217081 aaacgggtaa ttttcaaatt gggccttagg gaagtgaata ttatcctttt actaaatgca 217141 attatatttt tttactagta acataaaaat ctggagggag gctgtttaaa gatggatgaa 217201 ttagatatcg cattctttat tttaccgtta ggaattatgc tgctatcgat tgtcgggacc 217261 tgtatttgta aaaacccgta tctgatgcca atgcttagtt tggtgatttc tcttgtgctc 217321 acctttacca tttttaatca atcatttttg ggatgggctg ttgtctatag cttggtttct 217381 ctggctttat cctatatcac attgattgtg gtaaggaaaa ggaaggaatc aggaaattaa 217441 aaagacctca ctttctaaca tatcgttgac taaagcaact atatgtgatt ataattgctt 217501 tagtcaacga tattagaaag tgggaattga tttgaaaaca agagaatcat ctgtcgggtt 217561 aaaattcaga aagttcaatc gattttatac aaacgtcctt ggtttcctta atgagcacat 217621 ttacgacagc ccgttttcct taacagaaac acggatttta tttgagattt ataatacgcc 217681 taattgtacg gcaaaagctc ttcaggataa gctggggctt gaccggggat atgtcagcag 217741 gattgtgaag cagtttgaaa aagaagattt gatttataaa cagaggagca aagatgacgc 217801 ccgccaccat tacatttttg tcacagaaac aggaaaaacg atttataaaa agctggagga 217861 gaaagccaac gaacaagtag aactgatgct gaaggtaatc aaccaaaagg agcagcacaa 217921 gcttgccgag gcgatggcag agattgaagc gatcctttca cagtcgcttt ctgccagagc 217981 atcagagata tcgattagag attattttct ttcggaggat cttcaactcc ttattgagaa 218041 acaaagacaa ttttacgcgg aggctcacgg ttgggatgac acgtttttag cttatcttca 218101 ggagacattt gacgctgaca tcgaaaaaat atggattgcg gaaagcggcg ggaaatttgc 218161 cggctctgtc gggttggtca agcacgatga aaagacagtc cagctcagat ggtttctggt 218221 tgatgcggat tttcggggca gggggcttgg cacgcaattg ctggagcatc tggttgcata 218281 ctgccaagac atgaagtttg accgcatttt cctttggacg gtgagcacga tggctgaggc 218341 tcgtccgctc tataaaaaat ttggattcag gataagtgaa gtaaaacaag aagcgccatt 218401 atggggacag cagctgacag aagaacggtg ggatttggag ctgtcatgaa aagactgcat 218461 tatgcgtgga tcatcgtctc cgtcaccttt ttgatcttat tggcggttca gggggtgcgg 218521 ctgtcgtttg gtgcgtttgt ggagccgtgg gaacggcagt tttcaatcga tagaagcacc 218581 atctcgctga tttcgacggt gagttttatt gtttatggca tatcacagcc tgtgatcggt 218641 cggcttgtgg acaaatgggg tgcccgggct gttttggcat ggagtgcgtt actgacagga 218701 gtcagcattt tcttaacata ccttgtgact tcgccttggc agctgttttt gctttacggg 218761 ctgggtgtct cgcttggagt gggcggagca tcgaatgtgg cggcaagtgt attggtcgtc 218821 aattggttca gcaaaaagcg gggactagcc tttgggatca tggaagcagg ctttggcgcg 218881 gggcaaatgc ttctcgttcc cggctcactc atgttgatcc attggtttag ctggaagctg 218941 acggttgtgg tgttgggact gctgttaatc gtgattgtct ttccggctgc gctgctgatg 219001 ctgcggaaca atccttcaga aaagaataca gagccgatag gcggactggc tgcatcagaa 219061 aaagaaacag cacccaaaac aacagctctt tcagtggccg ggatgtttcg tatgaggcaa 219121 ttctggttct tgatttttcc gtttttgatc tgtggattta cgaccgtggg gctgatggat 219181 acccatttga ttccgttttc tcatgatcat ggcttttcaa cgacagtcac gagtgctgct 219241 gtcagtctgc tagcaggctt taatattgct gggatcttgc tgtccggaat tgtagcggac 219301 cggtggagca gccggaaaat cctgtgcatt ttatatgcgg tgcgggcgct gtcgatcgtg 219361 attcttattt acagccacga gccctacttg cttttagcct ttgcgattct gtttggatta 219421 gtggactttg caacggtagc accgactcaa atgctcgcca cccagtactt tcaaaactac 219481 tcgatcggcc tcatgattgg ctggctgtca ctcgcccatc agatcggatc ggcactaggt 219541 gcgtatgtgc ccggcgtcat ctacacggta acgggtgagt atacactggc tttttatttg 219601 tcgattggaa tgctcgtgct tgcgagcgta atgaatgtga tgctgaggga gccagctgcg 219661 gttacgcgtg acagtgcggc tgtggtagac aagtgatgag gacaaaggga aagcatctct 219721 gatttcgaga ttattcagag atgctttttt tgtatttttg ttctaatacg aagtcgatca 219781 taccgactat gcgggcgttt tcggattttt gtttgaagcg ttcagaaatt tgaacttttc 219841 ttgaaaatgg ggaaacaata aaaacccaaa aaaggccgat caaggcaaaa aacatttgta 219901 cagctaattc tattaattca ttaaaacgag tgctgaaaaa atagaagtat aacgttatta 219961 atgtcacagt acatacgatt ttggcaagtg tgtttgaatg taagcaatgg ttcactaaag 220021 aataccttta attgattcag catgattgaa tcatatttgt ttaggaaaat aagaagttct 220081 ttatcatctt ttttatgttc taaaataaag ttgctgtttc tgtttcttta tatgtatggt 220141 ggtctacatt caatatatac atctcttaaa gtataaaaat tgagtatttc ttagtaagga 220201 tgaaacaaaa ttacatgatt tttttgttat atctttcagt tagaataaaa tctataactc 220261 ctctcattcg caaatattcg gctctctgtg caaagtgcag aacagtatgt aattgtcctt 220321 ttctagatat atttaaaagc tttatcaaat caataaggat tttcaagaaa ataattaata 220381 atagaaagat aaaaatgtgt ggtatgtcaa tgtaattgat ttgtcctgaa aataaagaag 220441 ttgcatagac aacaataata cttccgcaaa acatcaaact catataatgt ggaagggaaa 220501 atggacgagt tgaaaaatat gcttttaatt ggcttagcat agcattatct cttgtatcta 220561 agtagcccaa aagctcttta tcatttttac taattgtaag aacatgattc aatacagcac 220621 taaaattcat tgaatcttca ttatcagagg cagtatgttt attagcctgt atgttttgtt 220681 gatccatttt atatttttta taaagtattg tattaattaa cttgtttttc tcatagaatt 220741 cagatcgttg attaagggat gcttttcctt tgtttttatt tccttttttt atgattttag 220801 tataagtcat aaaaatacaa atgactgtaa aaatagaaaa cactgcaggt gaaatatctg 220861 aaagaatagt attggtgaag acttcttttg cttggatgaa aaggaaagaa gctaaagtca 220921 tagatataaa catgcataaa actgctactt tcacaagaaa ctgaagcgga agagaaggtt 220981 ccgaataata gtgcttcaac tggttgagtg tcagagaatc ttggcgaaaa agataatcta 221041 ttatctcctg ctgattttgc atctgattga tatcatgagc gatgtttttt gttttttcaa 221101 aaactatttg atcatttttc atttttgata aacctccaaa agacgataga taaactaaaa 221161 aaactgcatg agcatatttt aacttatgtt catgcagttt tgtattaaag ttagctagta 221221 taataagcaa aaatggccag taacatagca gataatgcgg tagcgacttt gactccttta 221281 ttgttcgtta aatcactgcc catattccca attagtaaaa gtgcagcaac acctacaaca 221341 gggaataaat attgatcata agacggccaa tctaacgcta attcactctc gggagacgta 221401 actggtactc ccttgtacgt ctttatttta aacgtaatcg tagtcgttag tccagttgtg 221461 acattgtcac cgactggaat atcaggtgta tagattttaa tttgaatgtt taaagattca 221521 gctgttggat ttacataaac ctccaaataa ccgttgcgta ctgataagct cagactattt 221581 aaaaggtttt gataagagtc gatttgtgac gcagtgagag acgtttgagt gtcgcccaat 221641 aaacccgtga tataggcacc tggtttacca tttgtaatgg taattgtgtt tggtgaacct 221701 tcacttggta tggttgccag aagtgaagtt gatagaataa tatccaactc aggtgatgtg 221761 aaaatggttt ctgtcgtatc aaattcaaac atcgcgtttg ccagacttgt tagattttct 221821 aaagctggaa tggtagataa aatgtctgtc agtgtacgca gtcttgcatc atataccgga 221881 tcagacggcg gatttacatt gcttgcacct gagtctcttc ctgaataccc gtctttatca 221941 atcccgatgc ttccagagcc gcttccgatg gttccttcat aaaattgatc aaaggcccag 222001 ttgtttggca tcggatagcc gagattgccg ctaaatcctg ttgacatatt tgccacaaaa 222061 ctatactttg tcagtcctgc ttcagatgta cggatacaaa tgtttcttgg tccgtaaacc 222121 cctatttcat acttaggtgc ggttgaaaat gtctgcattt ttgtaaatgc tgacttaatc 222181 tcttggaaat aaggaatgat tttatcggtc acttcataat cgtatgcatc aaaatcgaca 222241 gcgaaataaa tggtcgtgcc tgacggaaaa cctaatcttc tagcagcaga agcggcacta 222301 tatgcatctc ttgtgccttg gtctttgaca aaataagaag attcatagcc gccgtcttga 222361 taaattggga aaaccttcaa tccggcatca agaataactg caagctcttt agatgtcagg 222421 gctttagatg tgaggccgct gcttgtccgc acatttccgg tcaaatatct gccaaccgtt 222481 ttataaccgt tattccgcag tgtttgagct ttttctgcgg ttataattgt agcagtgtca 222541 caagcagaag cggtgcgagt tgtgtctcct gagcttgata ataaagcttt aatggttggc 222601 atatctgcat aacctgtttg cggcaggcac atgaactctt gaaatgcttt aacagctgaa 222661 acaacaccca caccatattt gccgtcaaac tcaccaggat cgaacgattt tccgttacaa 222721 tagagggcgt actgaacaat taagacaaat cctgttcttg aatcgccggg agttaaagta 222781 gggcacaaac ttgtggtgcc gtttccgaaa aatccattgg caacacttgt gctcatgcct 222841 tcttcttttt gcagggcata aataagagct ttatttgtat cgcggccata cagtccgtca 222901 caaggcatta acccgatata gtcattgtag tctcgattta agttttgttg aatctggcga 222961 attcttgaat cacccccaga caccagctta aaagcgctca tgtctaataa ggctttcata 223021 attaacgtgg tgacaatccc atcctgtgtt gtcagtccgg cagctttttg aaattctttt 223081 accgcatttt ctgttttttc gtaaaagacg cctgtaaaac cgccgggatt aaagccttta 223141 caccataaag ccccttgtaa aataaaattc atgttgcttg gttttgaatc tggagcttgg 223201 cgtttaagag gcttaaataa gcgctgtgtt gtcggcccga agttatcggc tggctctgag 223261 atacccaatt caatttgaag cgcccgagtc agaccgtaga tcgtatccca cccagttttc 223321 ccgctttctt caactgggtt atacccatgt ttgccgctgt acgtatcgtt cagccattgc 223381 tgtgtgatta agaccatttc atcaaccatt tcgattcctc ctttgttaga ttgcgttcat 223441 ttataggtgg caaacgtagg acaaaataaa aaaatggatg ccgttaagca tccattttac 223501 atccgttctc caacagcttc gctttcggtt tcagctctga aatgtagagg cctaaaagtg 223561 taagcgcgcc tcctagaaga gcgatccatg tcatgttttc gtgcagaatc aggacagaag 223621 cggcgatcgt gataaccggg accatgtaaa tatacgcact ggatttgacg gctccgagca 223681 ctccaactga ataattccaa gtggcgaagc acagggcaga agcgccaatc cctaagaaaa 223741 gcatgttgag tatatttgaa gcagatgaaa atcggcttag gtcaaaatgg aagtcgaaca 223801 aaaataaagc gggaaccata aacaataaac catacaaaaa tactctctgt gtcagctcga 223861 tgatgtggta ttcgtaggcg cttaattttt tcatgaatat cgagtatccg ccaaacacga 223921 gagcagcccc ggctgccatg atgtctccga gcggatttag acgcagtacc acattgccgt 223981 taaacgtaat caataaaagc ccgatcagtg ccgagataaa tccaatcaaa aaagtcagac 224041 gcaatttttc gccttcgagc agaaaatggg ccaaaaccgc agtgatcatc ggtataatgg 224101 acacgatcat gccgacattg gaggcgtatg tataggtgag agctatattt tctaatagaa 224161 agtataaggt tacgccaaat aaaccagctc cggcaaacaa cagctcctgc cgccaatttc 224221 tgaacggaat catgttggga cggacgagga taagagcgat aaagcccatc aaaaaccgat 224281 aaaataatat ttccattgga gagaagtcag ccagcagaac ttttgtcgaa ataaaggtcg 224341 tcccccaaat cagaatggtc acaatggctg cgatatgccc cgaagtttct ctttgtatgt 224401 tcatctgtga agctcctttt caaaaatctt catgtattgc ttcggcgtca gccccacctg 224461 ccgtttaaaa aacttcgtca tatgactctg atcgctgaat cctgtctgaa atgccgcatc 224521 aatcggcctt accccttgtt caaggagttt tttggcttga ttaatccgga ttgtttccat 224581 gtagctatta ggggtaatgc ctttttgttt tgtaaatgaa cgcaataaat gatacttgct 224641 ccagcctgtt aattcactca aatcattgag tgtaacattt tcggcataat gctcttctaa 224701 aaattcacaa accattttga cttcgtctga tggttctgga acgctgctaa ggaacgtgac 224761 atctgaataa tggcggatca gctcctctaa tagatgaaga aacagctcct ccttacgcaa 224821 agcttgtttt tcctcggata tcaaaatatg caattcctgc aggctggctg tcagctcatg 224881 gcggaataac acatgctggg agaaataagg gagatgcccg gagccagtaa tctctttcac 224941 cgccttctcc atgatatccg gcatgacatt gatacaccga taatcaagcg tccggccgtc 225001 aatctgttca cagctatgcg tgtcacgggg gttaaagagg agaagatcac ctggattgat 225061 gatatattct tgatcctgac aggccagata ccgttgccct ttttcaataa atccaatcac 225121 ataataatcg tgaaagtggt tcgggaactt ctgcataatt cccttgaagc ggtaggcttc 225181 tatatgaagg tgtgggtcaa gctgcagtgt gcgggtttcg ttttgcatgg gatgcctcct 225241 gtcggtgtgg tggtcttgga ttaagtgtag catgattttg ggggatttct tgtatgatgt 225301 tgctgtttag gaatagagaa agcagaccgt tatttgtctg ctttcgttta agaatttaaa 225361 agattttaac cctcaataat aattttatct tttttaataa aaatttattt ttcaaatatt 225421 tcagttataa tggtttggaa cagataggag gggcaaagat gtatcaatca aagaaggttt 225481 tattgttagg ttcaggtgaa ttaggtaaag aggtagtgat tgaagcccag cgtcttgggg 225541 tacagacggt ggcagttgac agttacgagc atgctccggc gatgcaggtc gcgcataaca 225601 gttatgtcgt tgatatgctg gacccagagc agatcagaac catcattgag aaagaaaatc 225661 cggatttgat tgtgcctgag gttgaggcga ttgcgacgga tgaattgctg aagcttgaag 225721 aggaaggatt tcacgttatc ccgaatgccc gtgcggccaa gctgacgatg gatcgggaag 225781 gcatcagacg acttgcggcg gaaacgcttg gacttgcgac agctggctat gaatttgcga 225841 atacatatga tgaatttata caagcggcag ctcagatcgg ttttccttgt gtcgttaaac 225901 cattgatgag ttcttctgga aaaggccaaa gtgtgtgccg ctctgaagcg gatttagaga 225961 gctgctggga gacggcgatg gaaggcggac gggtgaaaaa cggccgcgtg atcgttgagg 226021 agtttatccc tttcgaatca gaaatcacac tcttaaccgt acgtgcggtt aacggtacgg 226081 cattttgtga gccgatcggt catgtgcaaa aggacgggga ttatatcgaa tcgtggcagc 226141 cgcatgatat gacagagcag caaatagaag aagcgaagca tattgcgaaa acgatcacgg 226201 atgagcttgg cggatacggc ctgtttggtg ttgagctgtt ccttgcgaaa gatagggtat 226261 atttcagtga ggtatctcct cgtccgcatg atacgggtct tgtcacgctg gtgacgcaaa 226321 atttgtcaga atttgcgctg catgtccggg cgattctcgg ctttccgatt acagaaatca 226381 cacagctttc tcctggcgcc agcaggcccc tcaaagcgcc ggaagaatta gcggattaca 226441 ctgttgaagg attggaaaac gcactggcag tcccaaagac tcaagtgcgc gtctttggaa 226501 agccgataac aaaagccgga cgtcgtatgg cagttgcgct ttctgctgct gattcagttg 226561 aaacggcaag agagaatgca aagaaagcgt tggaccagct aattttaaaa tagagtttga 226621 acaggtcttg tcatgggaca aggcctgttt ttttctttct ccgtaaaagt tttatcataa 226681 gaatcagaaa cctgattata atgtaaaagt cttccatcga tacgggtggt tgacactaaa 226741 ggagggagat gacaaaatga aattagttcc aagattcaga aaacaatggt tcgcttactt 226801 aacggttttg tgtttggctt tggcagcagc ggtttctttt ggcgtaccgg caaaagcggc 226861 agagaacccg caaacttctg tatcgaatac cggtaaagaa gctgatgcta cgaaaaacca 226921 aacgtcaaaa gcagatcagg tttccgcccc ttatgaggga accggaaaaa caagtaaatc 226981 gttatacggc ggccaaacgg aactggaaaa aaacattcaa accttacagc cttcgagcat 227041 tatcggaact gatgaacgca ccagaatctc cagcacgaca tcttttccat atagagcaac 227101 cgttcaactg tcaatcaagt atcccaacac ttcaagcact tatggatgta ccggattttt 227161 agtcaatcca aatacagtcg tcacggctgg acattgtgtg tacagccagg atcatggatg 227221 ggcttcgacg ataaccgccg cgccgggccg caatggttcg tcatatccgt acggtactta 227281 ttcaggcacg atgttttact ccgtcaaagg atggacggaa agcaaagaca ccaactatga 227341 ttacggagct attaaattaa acggttctcc tggaaacacg gttggctggt acggctaccg 227401 gactacaaac agcagcagtc ccgtgggcct ttcctcgtca gtgacaggat tcccatgtga 227461 caaaaccttt ggcacgatgt ggtctgatac aaagccgatt cgctccgctg aaacgtataa 227521 gctgacctat acaaccgata cgtacggctg ccaaagcggc tcgcctgttt atcgaaacta 227581 cagtgataca gggcagacag ctattgccat tcacacgaac ggaggatcgt catataactt 227641 gggaacaagg gtgacgaacg atgtattcaa caatattcaa tattgggcaa atcaataaat 227701 acagcaaact agccatattc atgtctattt tgtttttatg cgggtgcagt tcgcagacgc 227761 attcttctca aaaagaaacg actattcctg tcactcttca tgtggaggat gctaaggggc 227821 tgccggtcga aggggttcaa gtgacgattg tcaaagcgcc ctcttcagat gaggagccga 227881 gtacagagat tggcgagata ctcggtaaaa cagacaaaaa cggagatatc aaatgggata 227941 ccggcagaaa aggcgattac tcagtcgcgt tgacgaaggg tgaaacatca gtaacccatc 228001 acatctcgtt aacagaggat aaaaaagatc atgccattcc attagtcttc aaagaatagc 228061 agtttccttg attttaaggg aactgccttt tttatttatt gcaggaaacc aaactatata 228121 ctggaaattt attatgtgag ataataagaa ataggtattt tttcttacga gacaaaaggg 228181 gcgttatcct ttatatcaat caaacccgga ggaaaaagaa gaagatgata caagattcaa 228241 tgcagtttgc cgcggttgaa agtggtctgc gcttttacca ggcatatgat caaagccttt 228301 ctttgtggcc gattgagtcg gaagcattct atgtttctac tcgttttgga aaaacacata 228361 tcattgcaag tgggccaaag gacgcacctt cgctcatttt gcttcacgga ggccttttca 228421 gctctgcgat gtggtatccg aatatcgcag cgtggagcag tcaatttcgt acatatgcgg 228481 tcgatataat aggagacaaa aataaaagta taccatcagc agccatggaa acgagagctg 228541 attttgcaga atggatgaaa gatgtctttg attctcttgg acttgagacg gcacatctgg 228601 ccggcctttc gcttggcggg tcccatatcg tgaatttctt actccgcgcg cctgaaagag 228661 tagagcgggc ggttgttatc agtcccgctg aagcgtttat ttcatttcat ccggatgtct 228721 ataaatacgc tgcagagctt acaggggcaa gaggagctga atcatatatc aagtggatca 228781 caggcgacag ttatgatctg catcctttac tgcaaagaca aattgtggcg ggcgtggaat 228841 ggcaggatga gcaaaggagc ctgaagccga cagaaaacgg ctttccgtac gtgttcacag 228901 accaggaatt gaaatcaata caagtcccgg tacttctgat gttcggtgag cacgaggcta 228961 tgtaccatca gcaaatggcc tttgagcggg cttcggtatt ggtgccggga attcaggctg 229021 aaatcgtaaa gaacgccgga catctgttat ctctggagca gccagagtac gtcaatcaac 229081 gcgtcttgtc ctttttatgc ggggggataa aatagtaagg aacatgaaaa gattggcatt 229141 catttttcaa aaggtaacaa atgttgtata ataatagaat ttgaatgctg ctttttttgg 229201 gagcattcta tgttatcatg cttattggag aaaaattttt cctgtaacgc tattcgatca 229261 ctatcgtcaa ataatataga tggttttaca attggaggtt tggttacact gtgaattaca 229321 tcccctgtat gattacgata ggaaacttca tttgcggatt gctggcgatt cattccttgc 229381 tatatcacaa cattcattca gcagtgcttt ttatttttac aggcatgttc cttgatttct 229441 ttgacgggat ggctgctcgt aagctgaatg ccgtttctga tatggggaga gaactggatt 229501 cgtttgccga tctggttacg tttggggtgg ctccttctat gcttgcttac agtgtcgcgt 229561 tgtataccct gccatttatc gggatcttat gcgcattgac gtacagcatt tgcggaatgc 229621 ttcgcctctc taaatttaac attgaacaaa gcaagctccc gacgtttatc ggtatgccga 229681 ttccgtttgc gggcatgtgt ctcgttattc taagcttcac ctataacccg atccttctgg 229741 caatcggcac ttgcggactc tcatatttga tggtgagtaa aataaaattc cctcatttta 229801 aaaaacatgc ggcagaaaac ctggagtctg ggagatggaa ttagttcagc agctcatagc 229861 ggattacggt tatctcgcta tttttttgat gctggtatta ggaattgtag gattgccgat 229921 tccagatgaa gtgatgatga ccgttgttgg ctatttcacg cataccgatg tattgaatta 229981 tgagctttcg atattgatta gttttgtcgg ggctttgtta ggtatgctga tcagctacat 230041 gattggcaga aaagccggac gcccgtttat cgacaagtac ggcaagtggg tcggcttaaa 230101 agaaaaaaga atgatgaaag tggaaaaatg gatgaagaaa tacggtccat attctcttat 230161 tttaggttat tttattcccg gcgtcagaca tgtgacgtgc tacttttcgg ggatcggcaa 230221 aatggatctg aaaacgtatg ttgcgtttgc tgcaatcggc gcctttttat ggtgctttgt 230281 ttttattaca atcggaaggg ttatagggat tattcatgtt taatacggct gtaaagattc 230341 tgtatcgatc attgatagag ctgacgaatc atcgtctgtc atcctatctg attaaaggat 230401 tttgcgagtc gaaaatcagc aaaccggtca ttccgctttt ctcaaaacat tttcggctga 230461 attgggatga tgtggacggt acggctgctg attacggatc gctgtccgaa ttgttcattc 230521 gacaaataaa tctggagcgg cgccctgtgt caaaagaggc gcatgcggtg gtcagccctg 230581 ttgacggtgt ggttcagacg gtaggaatca tcaacccgaa tcaaaccttt acggtgaagg 230641 gaaaagatta ctcattcgct gagctgaccg gctgtaaaag cgcagaccat caatacaacg 230701 gcggatattt cgtcgtgctg tatttaagcc cgaggcatta tcaccgtttc cattctccga 230761 tcagctgcag gtatcaaaag ctggccgagc tcggaaatcg ctcatacccg gtaaatcaac 230821 taggcttaaa atacgggaaa gatgtgctgt cgaaaaatta tcggtttgtg tacgagctga 230881 atagcggcag ccgaaatgtc ctgatgattc ctgtcggcgc gatgaatatt aattctatcg 230941 tgcagacgaa tacccgtact gaattggaga tcggcgagga gctgggatac ttttcatttg 231001 gctcaaccgt cattttggtt tttgaaaaag acgcgttcca gccgtccgcc catttagcag 231061 aaggccaaga agtccaagtc ggagaactga taggttacga agaataaaaa gaggagcttg 231121 cataaacgca gcgcctcttt ttttgaagaa aggtgagatt catggagaaa caaatcatca 231181 gctggattac agattatcag aacaccggag atgaagccgt cctgcggcaa gtgcgagaag 231241 tgtgctggcc gatcgttgaa gcggttttgc aagagaaagt aatggatgat gaacaagcga 231301 acaatttgcg cgaaaaagga atcgagcggt ttccattcat catcagcaaa taccaagcgg 231361 atgtgcagct tccggttgag acatttttac aaaatacgta tcggttttac tttcatcagg 231421 tgatgagaga atccagctaa agcttctttc aacagagaag cttttttttg ttggcaggaa 231481 aaggaaactt tttctatatc tatctcgtaa tgactagaga acctagcaga aaaggagaga 231541 tagaattgaa acgaatgata gtgagaatga ccctgccgct gctgatcgtt tgtctggcgt 231601 tttcttcttt ttcagcctca gcccgtgctg cttctgaaga aaaatattgg gatcactgga 231661 ttgaacgaca tgcacagcct ctggatgctt ccaatgcttc aaacaaagac cttcgatttc 231721 taaaaaaggt gctgaaggga aaacgaatcg ttcagttagg agaaaccaca cacggtgctg 231781 gcgaaatcaa tgccacaaag gtcagaatga tcaaatacct ccacgaagag ctgggatacg 231841 atgtattggc ctttgaatcc ggctttcctg atacaaatgc atcctacctt aatatggacc 231901 aattaacccc taaaagcacg atgaaaaact ccatttacgc tgtatggcac acagaagatg 231961 tcgtcgaatt gtttgattac atgaaagagc aaaaagagaa aggcgatccg ctgatcctta 232021 ccggttttga tattcaaagc atgaagaatt cattcaatgt agctgcgact caatgggtaa 232081 aagcggtgga ccctgagaaa gcagagttgc tctcccaatc agaaaatgat ttttcaacat 232141 tagtgacaga cagcaatacg tttgatgaat tttcgcaaaa gaaggaaaag cttgtgaaaa 232201 actatcagaa gctgatcaag ttcactaaaa cacatgcttc agagctaaaa gaaaaccttc 232261 caaaagagcc gaaagcttat gagatgttta tgcattctct tcagctgaga attgacgtaa 232321 tggaaacata tatgctggaa gaaatgaaag aaaaactaga ggagtatccg gagaatattg 232381 aggatttttc attctttatg agagaccgca tgatggctga acaatttcag tgggtagccg 232441 acacccttta tccgaaaaag aaaatcattg tctggggcca caattaccat ctacgcaaac 232501 agaatacgaa gatgataaag gactgggtac agctaaacgg ccctaacatg ggtgattatt 232561 tgccggagcg gctgaaaaaa caaacatata cgattggcat ttatgcttac tcaggtgcga 232621 gtcttgatag ctccgataat aagactgtta agccggttac aagcccgccg ccgtctggga 232681 gccttgaagc tttgctgaaa gcggcggacc gaccggctgt ttttgttgat tttctccata 232741 caaaaaacaa gaaaggcact tcgtggatgt ataccccgcg gactgcgctc tattgggggt 232801 acatggaaga gcagatgatc ctgaaggaac aatatgacgg tgtcatttgg ctggagcata 232861 tcacgccctc tgtcattatc aagtgagcgg tgtcccctgt ggtaaacagg ggatttttac 232921 atatcgcaaa aataatcaaa acatataatc cgtgatccat tattctaaaa cagaaaggag 232981 attggagcgt gcaatgtatt atgaaaaagc tgtccagaaa acaatcaatt ggattgaatc 233041 acatttacat gagcaaatat caaacgagga tattgttaac gtttcaagct tttcaaaatt 233101 ccattttcat cggatttttc aaaaagaagt cggcatgtcg gttgcttctt atattcggtt 233161 aagacgtctt gcgaatgcgg cggcagcttt gctttataca gatcatcgta ttatcgatat 233221 tgctttgtat tatcagtttg aatctcaaga agcatttacg aggacgttca aaaagatgta 233281 tcacatgccg ccaggagcat accgaacatt tatgaaacgc tttacttcaa aaaaggagga 233341 atcttacatg gagaaaaaaa tgaaaggctg ggtattgagc gggagccatc cgttccaatt 233401 cgaaatgggg attgaccggg aaaatgtaca tcagggaaaa gcttcagggt atttaaagtc 233461 aacgatggtt caggatatcg gtgaatttgc gacgatgatg cagcaattca aagcagatcg 233521 ctatctagga aaaaggcttc gtctatcaag ttttatcaaa acaaaggggg tgcagcattt 233581 tgcctcactt tggatgcggg ttgacagtgc tgctgatgat gttctccaat ttgataatat 233641 gagcaacaga cctattaccg gaacaaccaa ttggaatcat tatgctatcg ttttagatgt 233701 cccagaaaat agcgctgtga tatcttttgg cgttcaatta tctgggccgg gtcaggtgtg 233761 gatggatcat gttgtttttg aagaggtaga tgagagcgtt ccttcaacaa accttgaaat 233821 gccgggagaa cttttagatg aaccggtaaa tttatctttt gaagaggaac tacaaaaata 233881 gttttcagac aactactttt attagtgagt taatggaaaa tactatttgt tattaataaa 233941 cccttgtgct gcttaggttt gtaagagctt ggatattttt atcagtctgg gcggatctgt 234001 tcatctttgc ggcattttcc tgtatgatat agtaagagtg tgcatagcaa ctaactataa 234061 ttgaacaggg tgtttaaaac atggaaaaac aatacagagt attactttac tataaatatg 234121 ttccgattga agatccagag gcgtttagag agcagcatct ggctttttgt aaggagcttg 234181 gtttgttagg ccgtatcctt gtttcttctg aaggaattaa cggtacggta tcaggtacgg 234241 ttgaacagac tgaaaaatat atggaaacaa tgaaagctga tcctcgcttt gcggacatgg 234301 tatttaaaat tgatgaagca gaaggccatg ccttcaaaaa aatcttcgtc cgccataaaa 234361 aagagcttgt aacgcttcgt cttgaagatg atgtcgatcc gaacgaaaca acaggccagc 234421 atttgaagcc tgcagaattt tatgagaaga tgcaggatcc aaacacaatt gtcatcgacg 234481 cgcgtaacga ttacgagtat gaccttggcc atttcagagg tgcggtccgt cctgacatcg 234541 aagccttccg tgaattacct gaatggattg aagagcacaa agatatgctt gaaggcaaaa 234601 agattttaac gtactgtaca ggcggcgtgc gctgtgaaaa gttctcagga tggctggtga 234661 agcaaggctt tgaagatgta gctcagcttg atggcggaat cgtgacatac ggaaaagatc 234721 cagaggtgca aggcaagctt tgggacggcc agtgctacgt atttgatgaa agaatcagcg 234781 tgcctgtcaa ccgtgtcgag catgtgattg tcggcaagga ctactttaca ggagaaccgt 234841 gtgagcgtta tgtgaactgc gcaaatccat cttgcaataa aaaaatgata tgcacaccgg 234901 aaaatgagta taaatatatg cgcagctgca gccacgaatg ccgcacgaac ccaagaaacc 234961 tgtatgtgaa agagcataat atgacagaag aagaagtaaa cgcaagactg gcagcgattg 235021 aaacagaaga tcacgctgct gctgaataaa aaaagaacac ctcgtattga ggtgttcttt 235081 ttttctatat gctttcagtt tggctgtttg cggaaaccca ttctttttgg cggaaggcct 235141 tttcccattt tgataccacg atacaggcga tcgcatgtcc cggtacgttc acgcctgttc 235201 tcgccatgtc catgacgcgg tcaacacccg cgataatggc aacgccttca gccggcagtc 235261 ctacagcatt ggcagtcgcc agaagaacta caagcgatcc tgagggtaca gctgcaatgc 235321 ctttactggt catcacaagc acaagcatca tgagcagctg ctgggacaat gtcatgtcta 235381 cttgaaaggc ctgtgcgaga aagatacaag aaaccgataa atataagctg gagccgtcac 235441 agttcaatga caagccggag ggaacgacaa atgataccac tcgtttggga cagccgtatt 235501 tctccattct atccatcagc tgagggagaa tggtttcagt gcttgtggtg gaaaatgcaa 235561 ttaaaaacag atcccatatc attttcaata cttcgaaata cttaatctga aagatgagac 235621 cgacaagcgg aaagaggaca aagaggatca ggaacaggcc aaggaatacg gtgccaacca 235681 gcttaaacat agggaggagg agttcaatgc catattggcc tacagaagca gccatcaggg 235741 ctaacacgcc gataggagca gtgaccatga cgatttgcgt gagcttgaac ataatctgag 235801 ctgtagattc aaaaaacttc attactggtt cagaagcttt gccgatacca gctgcggcga 235861 caccaaataa aatggcgaag aaaataacgg caagcaaatc atttctggcc atgacatcaa 235921 taatgtttgt agggataata tccaggatca tttgcttgaa atcaacaact ttgtctgtgt 235981 agccggaaag ttcatgaata tctttttttg ccaaatggga gaggtcaagc ccgacacctg 236041 gttttaagac attcgctaat aaaagtccaa gccctaatac caacgttgta atcacttcga 236101 accaaatgat cgtcttgatg ccgagactgc ccattttttt catgcttccg cttcctgcgg 236161 ctccaatgac aatggtagaa aatacaatcg gcacaacaat cattttaatc aggcggataa 236221 atccatctcc gacaggcctc agtgccatcc cgaaatcagg aaaaaagtgg ccgatcaccg 236281 cgccgacagc caaagcgatt aaaatttgaa acgcgattaa ttttttcaaa tgaatccccc 236341 tttagaacga tagaatgtag gcatattcat atcattcgtg attcaaatgc aaacaccttt 236401 tttcaagtta ttttattttg acagcgcttt cattatgttg gcgaaaaagt cccccgcagc 236461 aggggggact tttttacttc atttgaatgt gctttagatc ttcttcagag gtatttgtga 236521 aaataaccgg tgttatggct gaagcggcat gctgcttgat gtaattgaga tcaaaggtga 236581 gaagcagttc gccttgtttg acggcttgtc cgcttgtgac atgtgcttca aagccttccc 236641 cattcagttt gacggtatcg atgccgacat gaatcaggat ttcagtgccg ccggcgctca 236701 taaagccgat ggcgtgtttt gtcggaaaaa tcgagacgat ctcgccgtcc gcaggtgcaa 236761 cgacttttcc ttctgatggt ataatcgcaa atccctcgcc catcattttt tctgaaaaga 236821 cctgatcagg cacatcccct aaagagactg tttctccttt aatcggataa ataaaggtct 236881 catcggaatc gggcttcagc ggtttgtcag ttaccgtgtc cagcgcggcg gcggtggcag 236941 ggacgcctcc ggccatgatt gttttgatgt cgtcttttaa ggcatcggac ttggttccga 237001 atattgcctg gaagttgttg ttgacctcca gcacacctac tgcaccaagc cgttttaatt 237061 catccttgca gacttggctt ggctgatgaa cggtcacacg aagccttgtg atacatgcat 237121 ccaggttagc gatattttgc tgtccgccca aggcctgcag cacgtgaaag gcaagctggt 237181 cttttgcaac tggagctttc tcctcattct gaccgtcttc atctgtctca cggccgggcg 237241 ttttcaaatt ccatttcaga atcgcaaatc ggaacaaata ataataaatg aaagcaaaca 237301 cgatcccgac aggaatgaca acccagccgt ttgtagacag tccgtagttc aagacgtagt 237361 caattcctcc gcctgagaac gtatagccgt ggcggacatg gaataaatca caaacgacaa 237421 agatgacgcc ggcaagaata gagttaatca aatagagcac gggcgcaacg aacaagaaag 237481 aaaactcaac cggttctgta attccggtca gcatagatgt gagcgccgca gaaatcatca 237541 cgccggagat catttttttc ttttccggac gcgcggtatg gataatggca agagcaacgg 237601 ccggcagaca gaaaatcatg taagggaaat cccccatcat aaagcgcccg gctgtcgggt 237661 ctcccgcgaa aaaccttgtc aggtcgccgg ttacggtgtt gcctgttgat gggtctgtgt 237721 attctcccat cataaaatag aaaggcgtat aaaaaatatg atgcaggcca aaaggaatca 237781 gcaaacgata gatcgttgca taaaagaaca ggccgactgt tgaatcggca attaaactgc 237841 tggctgcgtt aattccgttt tggatcagcg gccaaacgaa tgagaaaatg acgccgatca 237901 ccaatgaact gacggaagta atgatcggga caaagcgttt tccagagaaa aatccaagga 237961 ccggatgcag ctcgattgat gaaaatcgct tatataaata ggcggcgaga agcccgataa 238021 tgattcctcc gaaaaccccc atatcaatca ggtgctcggc tccttcatac ggaggctgaa 238081 ggccgagtaa ttttcccata ttgtcgaggg tgacggttaa aattaagtat ccgatgacag 238141 cggcaagtcc ggctacacct tctccgccgg ctaatccgat cgcgaccccc acggcgaaaa 238201 tcagcggaag gttatcgaat acaacgccgc ccgcatcctt tataataggg atgttcagta 238261 aatccttgtc tccgaaacgg agcaaaagac ctgctgccgg caggacggca accggagtca 238321 tcaacgcgcg gccaagctgc tgcagaattt gaaatgcctt tttaaacatg acagtctcct 238381 tttattgtgt tatgagaatg atgcactctt taatttttga gctgctttat aatcggcgat 238441 aacggttaca tgattgtgtt tttgaagaat ggaggctggt acatctgtcg tgacaggacc 238501 ttcagccatc ttttgaatgg cgtctgcttt ttcctcgccg cttgctaaaa gcacaatatg 238561 tttgctgaat tccatgatgg ttttaatgcc cattgaaatc gcgagtctcg gaaccagcac 238621 cggatcgccg ccgaagaatc tggcatttgc ctgtatcgtg ctttccgaga gcttcacaac 238681 acgtgtccgg tcttcaaaat cagatcccgg ttcattaaaa ccgatatggc cattggcgcc 238741 gatgccgaga atttggacat caatgcctcc cgcctggcgg atgagatcct cgtatacttt 238801 gcatgccgcc tcaagctgcg gattgtctcc ttgcgggata tgaatatgat caggctgcat 238861 attgatatgc tgaaaaagat gctcatgcat aaaatggtta taactttgcg gatgagatgg 238921 agagagacca gcatattcat ccaaattaaa tgtagtaacc tttgaaaaat caatttcgcc 238981 tgcctgatag tctgaaatca actgcttata caagccgacc ggtgtgcttc ctgttgccag 239041 gccgagaacg gcatctttct tagcttgtat ttgttcttta ataatggcag cgcttaactt 239101 acagagttct tcgtagtgct cggcgatcag aatcttcatg tgacaccccc tcaaagagat 239161 agacaagcac catatttgtt atgaccaatt tatgatactt gtcattacga atttagcacc 239221 gcccttatca aactgtcaat attaatttct gaaaatttgt tataaaagaa ggatacaaat 239281 ctttcatatt gggagggcaa atggtattat ggtctcaatg aaaaagaacg gattgcatac 239341 agaatgggga gaatgaaatg acagctttat attctgttat caagtttaaa atcattgagt 239401 taattaaatc gggcaaatat caggcgaatg atcagctgcc gacggagagt gagttttgcg 239461 aacaatatga tgtcagcaga acaactgtga gactggctct gcagcagcta gagcttgagg 239521 gatatattaa aagaattcaa ggaaaaggga catttgtatc ggcggccaaa atacaaacgc 239581 cgattccgca taagattacg agctttgcag aacaaatgag aggacttcgt tctgaatcaa 239641 aagtgcttga gcttgtggtg attcctgccg atcattccat cgccgagctt ttgaaaatga 239701 aagagaatga acctgtcaac aagcttgtca gagtcagata cgccgagggg gaacctttgc 239761 agtatcatac ctcatatatt ccctggaagg cggcaccggg gctggcgcag gaggaatgca 239821 ccggctcgct gtttgaattg ttaaggacaa aatacaatat tgaaatcagc aggggcacgg 239881 aatcgatcga accgatttta acggatgaaa cgatcagcgg acacttatta accaatgtcg 239941 gagcgcctgc gtttttatca gaatccctta cctatgataa aaatgaagaa gtggtggaat 240001 atgcgcaaat tattacacgg ggagaccgaa cgaaattcac cgtagaacag tcatatcatt 240061 cataaagcaa tgtgttttaa gaagggaatg gtggttctat gtttttattt acgaatggaa 240121 aagtgctgtg gggagcagtg attgctgcat tcatcctttc aattgtattt tacccttttc 240181 tgccgacgca gatgccgatt cattatgatg ttgcgaacag tccggatctg acggttaaca 240241 agctggcggg gactgtgatg ctgcctgttt tgatggtggt gtttgcatgg gcgcggaaga 240301 tcaattggca atttgtattc gcagtgtata ttttgctgat ttgccacatt gtcgtccttt 240361 gtttagcgct ctaaatcaaa cagccagaat aaaactggct gttttcttta atttcagctt 240421 catctgacaa tgaatgtggt gtataatagc tgatgatcct aaagaatatt ctgaaattta 240481 taggtgtgaa gcggcgtatt attaaaggaa aggctgtata ctttttgcag ctttaaaaag 240541 actgaatatt taaacaatta tgtgaaaggt gtgctgatta gattgaataa gcttattgaa 240601 cgagaaaaaa ctgtatatta taaggaaaag cccgacccgt cttccttggg gtttggacaa 240661 tattttacag attatatgtt tgtgatggac tacgaagagg ggattggatg gcatcatccg 240721 agaattgcgc cgtacgcacc gcttacgctt gatccgtctt catctgtttt tcattacggc 240781 caggctgttt ttgaaggatt aaaagcatac agaacagacg acggcagggt gctgctgttc 240841 cgtccggatc aaaatatcaa acggctgaac agatcgtgtg agcgcatgag catgccccct 240901 ttagacgaag agctggtgct tgaggcattg acgcaattag ttgagctgga gaaagattgg 240961 gttccaaagg aaaaaggaac gtcactgtat attcgtcctt ttgtcattgc cacagaaccg 241021 agtctcggtg tgaaggcatc caggagctat acatttatga tcgtgctttc gcctgtcggc 241081 tcctattatg gcgacgatca gctgaagccg gttagaatct atgtcgaaga tgagtatgtg 241141 agggcggtca acggaggagt cgggtttgca aaaacggctg gaaactatgc cgccagtctt 241201 caggcacagc ggaaagcgaa tgaactgggc tatgaccagg tactgtggct ggacgccatc 241261 gaaaagaaat atgtggaaga agtagggagc atgaacatct ttttcgtcat aaacggggaa 241321 gctgtcacac ctgctttaag cggaagcatt ttaagcgggg ttacacgtgc gtctgcgatt 241381 gaattgattc gaagctgggg cattccggtt cgtgaagaga gaatatcgat tgatgaggtg 241441 tatgcggcct ctgcacgcgg agaattgaca gaggtctttg gcacaggcac ggcagcagtc 241501 gttacgcctg tcggtgaact caacatccat ggaaaaacgg tgattgtagg cgacgggcaa 241561 atcggggacc tctcgaaaaa gctgtatgaa acgataacag atattcagct tggcaaggta 241621 aaaggcccgt ttaactggac agtggaagtg tgaaaatcga aaaagaacct gcccggaggc 241681 aggttctttt tattttgaat gagtcatatc agcagccggc tggcttttgc ggttttttac 241741 ataatatatt gcatagcaaa tggccataaa tggaacgccg caatagagtg cgattctttg 241801 attcggatca aaggcaatgc caacgacgga agccaggcat aacaggaacg cagcaatcgg 241861 cacgaacgga tacaaagggg ttctgtattt caaatcagta accttgtttc ccgcttcgat 241921 ataacgtttt ctgaacatga attgagaagc agcgattccc atccacacga caacgacggc 241981 aaaaccggaa atcgacacga gcacaacgta tacagtgtct ggcgcaaata cgctggacag 242041 caacgacaga atgccgccga tcatgctgaa caccagcgcg ttaaaagggg ttccttttga 242101 cgtcagcttt gcaaatgtcg gatgaagcgt tttttctttt gataaagacc acagcatccg 242161 ggaagaagcg tagagtccgg aattagccgc tgacaggatc gctgtcagga taacaaagtt 242221 catgatatcg gctgcgtatg gtacaccgac tctgtcaaag acagcgacaa acgggctttt 242281 gatgacacct gcatcttgaa tcggaatcag ccctgacagc acaaaaattg ttccgacaaa 242341 gaagagcgag agacgccaga ccgttgtttt tatcgctttt ggtatcgtct tgtcaggatc 242401 aacgctttca ccggctgcga ttccgattag ttccgttccc gaaaaggcaa aattgacgga 242461 cagcatcgtc atcaaaatcg ggacaaatcc attgggaaaa agcccgcctt ccgccgtgaa 242521 gttggacagc atcggagcgg cttctccgcc tttgatcggg atgatgccga acatggcaga 242581 gccgcctaaa agaataaata atacaatggc taatactttg atgctggaaa accaaaattc 242641 tgattcagcg aaaaacttga ccgaaaatgc gttaagcaag aagatgaaca gcgcaaagac 242701 ggcactccac atccaaaccg atgtatgggg gaaccagcgc tgcattaaca ggccggctgc 242761 tgtgaattct gatcccaatg ccacggtcca tgtcagccaa tacagccaag cgaccgtaaa 242821 tccggtgccc ggccctatgt atttggctgc ataggtgtga aaggcgccgg tcacaggcat 242881 ggcgactgac agctcaccga ggcatagcat gaccagatag acgatgccgg ccccgactaa 242941 gtaggcgagt atcgttccgg ccgggcctgc ttgctgaatg gtataacctg agcttaaaaa 243001 cagcccggtt ccgatgacac ctcccaagga aagcataaag aggtgccggc ttttcatact 243061 tctctgaaag gttgtctcat tcttgttgtg ggcagagttc atctttttcc aactttctat 243121 cagcgattta tttccttcct aataaaaaat ctcatgtcag aaagtgacac gagactccgg 243181 cgaaccggct ttaagttaga atatacaaac tattccgata agtcaagttg tttttaaaga 243241 gcgggcccaa gccgcaattt cttgaatatt ttcgggtttt gtccggcagc agccgccaat 243301 cagcctcgct cctttttcat gccaggtgcg ggcgctcgcc ccgtaagatt ctgcgcatgc 243361 tgcgccgttc cacgtttttg tttccggatc atattgctca cctgaattcg ggtagacaat 243421 gatcggtttt gacgtgttct tttttaactc ctctatcaag gaagggatat gctgaagcgg 243481 cgtgcagttg atgccgagtg ctgcaatttg gcggtgttca tcaagccacg atgcgcagtc 243541 agctgcaggt gttccgtcac tgatatgcaa gccgtcttta gcactgaagc tgatccatgc 243601 atacgtttca ggaaattcct tcaacagccg aacaatcgct ttggcttcag tcagacacgg 243661 aatcgtttcg catgccaata catcagctcc ggcttcaatc agcgccttca tccgggggcg 243721 atgaaattca atcagttcat cttctgatat tgcgtagttg ccgcgatact cagacccgtc 243781 tgcaagataa gcgccataag ggcctataga agccgcaatg atcggttttg gccgattcaa 243841 acggttctct tcaagcgacc aaaattcatc acgtgcttca gctgcgatgc tgacggacaa 243901 ctcgatgagc cggcgtgctt ccgcttcgct cagcccgcgt gcggcaaagc cttcaaatgt 243961 agactgatag ctggcggtga ttgcacaatc ggcgcctgcc gcaaaataat cagtatgaac 244021 ttgtttaatc agctccggct cttccatcag gatttttgcc gaccacagac tgtcattcaa 244081 attacagccc ttgcgttcaa gctcggtcgc catggcgccg tctagcacaa taagcgggta 244141 tgtatctaat atgtgttgga taggattcat agaatgtacc gatgccttct ttcagatttt 244201 tttgaaaaag atatgaaaat cgtaatggag gcttacgtgt ttgtcaataa acgcaaaaag 244261 agaaaggtgt tcagcccata tgtctgaaca cccttttctt atgatatttg tttgttgtgc 244321 gtgtcagtct ttgtgtctga aaccggccag cactcaatgc cattatggtt tttgagcaca 244381 tctttataaa agaccggatc cttgcctgct tttttctggc gtgtatagtc tttcagcgcc 244441 gtaaaaacga cctttgatag taagaaaatc gcgattaaat tcacgatgac catcaaaccc 244501 atgaacaaat cagcaagatc ccagacgagc tggactttgg caacacagcc aaacacgatc 244561 attgccagca cgccgatacg gtagacaaaa atcagttttt tgcttttgtt caaaaagccg 244621 atattggttt cgccataata atagtttcca attagagcac agaatccgaa taacaaaatc 244681 agaatcgcga gaaagcctga tgcccatgat ccgacatggg agctgaggga ggcttgtgtc 244741 aaggcgattc cgctcagacc cggagtatga taggcatccg aaaacagaat gataaaagcg 244801 gtgcttgtac aaatgaccag tgtatctgtc agtacaccaa aagcttggat cagcccctgt 244861 ttgacgggat ggcttgttgt ggcggtggca gcggcatttg gtgcgcttcc cattcccgct 244921 tcgtttgaaa agattccccg tctgacgcct tgcatgagtg ccgcgcccaa agccccgccg 244981 gcggcctggt caaaaccaaa cgcatttttc acgattagcg caagcacacc tggcagctgc 245041 gtaatgttgg agaaaatgac gaaaaacgca actccgatat acaggacagc caatacgacg 245101 acaatggatt cagccagctt tgcaatgcgc ttgactccgc caaaaataat cgtgccgaat 245161 acagcaatta aaatgagtcc caatgtcagg cggtttgtgc caaacgcgtt ttcaaaggca 245221 aggctgactg tattggattg aaccgagttg aagacgatac cgaacgataa ggtgattaac 245281 acagcgaaca gcgcgcccat ccaccttttg ttcagccctt tttccatgta atacgccggc 245341 ccgccgcgga agccgtttac atcttttact ttataaatct gagccagtgt gctttccaca 245401 aagctggatg ctgatccgat aatggcgata atccacatcc agaagattgc accgggcccg 245461 ccgagtgcaa tggcgatagc aatgcccgta atatttcccg ttccgacacg ggccgccatg 245521 ctgatgcaaa aggcttgaaa cggagaaatg ctgttttttg accgggaagc agcaccttct 245581 cttaataccc tgaccatttc tttcagcatg cgaacctgta aaaacttaag cctgaacgta 245641 aaatagattc caaaagaaag gagcaaaaca attaatagct ttgaccacaa aagatcattt 245701 gcaataccga cgatatgttc taggatttgc tgcatagaat cacctctttt ttcatgttta 245761 aaaaatgctg agctcccatt cctgcgccat atgcttcagc agcataccgc cagtgaggct 245821 gttgccgtat tcatcaatgg caggcccgta aatgccgatg ccgcatccgg attgaaaagg 245881 ctgttctctt ctggcgcttg gaggcaccag cgccatgatg ccgccggaga cgccgctttt 245941 ggccggcacg ccgacaaacg ccgcatattt gcctgaagcg ttgtacatgc cgcacgtcag 246001 cattaatgcc ttggccaatt ttgccacatc ttttggaatc acctgctcgt gtcgaatcgg 246061 atgatacccg tcatgagcaa ggatcaggcc gatcaacgca atatcttctg tagtgctctc 246121 catagcgcat tgcttcaagt acacctcaag tgtttcttct acttcagctt ctaaaaagtt 246181 tgtttctttt aaatagtagg ccagcgctct gttgcggtgg gcggtttccc attcagaacg 246241 gaatacttct tcatgaattc ttggccgttt tcctatcaaa gtttccatca ccgagtaaag 246301 aaactcgagc ttttcgtatg cagattctcc gggaaggatc gaagcgatgg tgagggcacc 246361 cgcgttgatc atgggattga agggctttcc cggcttgttg atttcgagcc gaatgattga 246421 attaaaggcg tcacctgtcg gctcgacatc tacgcggtca agcacatagg gaatgccgcg 246481 gctcatgcag gcggcaataa agctaatcac ttttgaaatg ctttgcatgg taaaagagac 246541 gttccagtcg ccggcgtgta tcatcgttcc atcaggctcc aatacacaga tgccgagctg 246601 tgaatcattg acttttccta aagcggggat atagtttgcg ctttgtccat tggcggcaaa 246661 agggcgatag tattcaaccc aatcatgaag ctgtaacgcc gggtttatgt ctttctggtg 246721 ctcttttatc aattctttca tcgaattcct cctcactgat ttttttctta aaggactgag 246781 gtgtatcaaa acgaaggcta agggggcgtt aaacgctttc ataatagcgg aaggtataat 246841 tactgtataa tggagactac agaatcatac aaaatacgac aaaaacattt tgaaaataag 246901 cagtaagatt tataaaaacc tcatgttctg ggtcaaaagc aatttgcagg ttttctcccg 246961 attccccaaa ataaaaagcg aggatgtgat caacataaaa ctggaacggt ttattgaaaa 247021 agacggatat atactggccc tcatgctgat tacggtgccg ctggccggtg aactgaaatt 247081 ttatcccctc aatgaagaat tccgggtcag ctttggggca ccggtttttt tcttcttttt 247141 atcattgttg cggcatgtgc ccgctgtgct gccgggtttt ctgactggag cggctgtttt 247201 catctttcgc gtctttctgg aattatgggg cggaggacac aatgggctga ctccgattct 247261 gtatgatcaa gcgtctggct ttttctttta tatgacttac gcctgtctgt tttccatatt 247321 aaaggccaat cgtttccgtg aacggccgat tatgctcggt ttcattgggt ttatgattga 247381 agttgtgtca gattgtgtcg agctaactgt gcaatttctc atttttcata cggttgtcac 247441 gcctgagaaa atcactgaca ttgcggtgat tgcgatttct cacacattta ttgtgatgag 247501 cttttatagt gtgctgaagc tgtatgaaac acaatcgaga gaaaaacaga caaggcagca 247561 gcacgagcac atgctgatga tcgtttccaa tttatatgaa gaaacggtgc acctaaaaaa 247621 gacattgaaa acgacagaga aagtgacaaa cgattcgtat cagctctatc gggaaatgaa 247681 gggcaaggat gttcagctga gcggcagaat cctgagactg gccggagaga ttcatgaagt 247741 gaaaaaggac aaccagcgga tattcgcagg gctttcaaaa ctgatttcga atgagagttt 247801 gagagattat atgagggctt ctgatttgct gcagctcgtg attcgaatga atgaaaagta 247861 cgctgaagca ctagggaagc agattgattt ttactgctcg atcgagggag agcatgacga 247921 atatcacgta tttatcgtgc tttcgatcat taataatcta acagcaaatg cggtagaggc 247981 tatggatgaa gagggaatgg tcagcctgag gctccgtaag ccaaatgaga gtatggtaga 248041 attccaggtg gaagacaatg gccccgggat ttccgagaaa atcggagaca ttgtgtttga 248101 cccgggcttt acttcaaaat atgacgaatt tggcacgcct tctacgggta tcggactttc 248161 ctacgtaaag gaaatcgtga cagagctaga aggggatatc acgtttgata atcagcagcg 248221 gggagtggtg tttgccatca ggctgcctgt ccggcatttg attcagaaag ggtgaaccaa 248281 aagctatgcg tttttttatt gcagatgatg accgtgcggt gcggtcaatt ttaaggcaga 248341 tcattgagga cgaagatctc ggggaagctg ctggtgaagc agacgacgga agccaagtgg 248401 aagggcatat gctgcaattt aagcagattg atattttatt aatcgatctg ttaatgcccg 248461 gaagagacgg cattgagacg attcgtcaga tccagaatac gtactccggc aaaatcgtaa 248521 tgatctctca agtggaggcg aaggaaatgg tcggggaagc gtactcgctc ggcatcgaat 248581 attttatcca taagccgatt aaccgcattg aaattgtcac ggttctccaa aaggtgaagg 248641 agcggatcga gcttgaacac tcgattggag ccattcagca ttctctaagc cggcttgtca 248701 atcggactga acggaaagcg cgtccccagc agaagagtga cagcggttta aaagaggcag 248761 gaacattcct gttgtccgag ctgggcatga tgggagaagg cggcgcacat gatctcatgg 248821 cggtcctgca gtatttagca gaacacgagc aatccgagcc gcacgaaaaa caaagccctt 248881 cgctaaaaca aatattcacc caagtagcgg tacggaagct ggggacagga gcctcacaga 248941 cggaagtcaa tcgcgaaatg aaagcctcgg agcagcgtat ccgcagagcg attattcatt 249001 cgctgcacca ttttgcttca ctgggcacaa ctgatttttc gaatccaaaa tttgaaacct 249061 atgcatcgaa attctttgat tttccggttg tcagccagaa aatgaaagaa ctccaatcca 249121 aggatgcaaa accccttgca cctgctagaa taaatatgaa aaaattcatc cacgtgtttt 249181 ttttggaagc aaagcttttg catgagacga tgaaacaaag aaggatataa accaaacagc 249241 cggctgacca ggctgttttt ttgctgcgca gaatcccggc cggacagtga tttaccgctt 249301 ttttataaaa tatcagaaaa taaagatatt gacttattgt ttatttgtct tacaattaaa 249361 caaaaggata tatgggaagg agcggatgtg aaagaaaaat taataaaagc gcttacagat 249421 agaggccgta tacacaaata acaggaggtt atgttgatga gccgtatcag aaaagcaccc 249481 gctggaattt taggttttcc ggttgctcct tttaacacac aaggaaaact ggaggaagaa 249541 gctctttttc aaaacattga gtttttgctg aatgagggct tggaagcgat atttatcgct 249601 tgcgggtctg gtgaattcca atctctcagc cagaaggaat atgagcaaat ggtggaagtc 249661 gcagtctcgg cagccggagg aaaggtgccg gtctacacgg gggtgggcgg caacctcagc 249721 acagcgcttg attgggcgca gctgtcggag aaaaaaggcg ccgacggcta cttgattctg 249781 cctccgtatt tggtgcatgg cgaacaggag gggctgtacc agtatgcgaa aacgattatt 249841 gaaagcactg acttgaacgc gattctttat cagcgcgata acgcagttct ctctgttgaa 249901 cagatcaaac gtctgaccga atgtgaacag cttgtcggtg tcaaagacgg ggtaggaaat 249961 atggatttga atatcaatct cgtctatacg atcggcgacc gcttgggatg gctcaacgga 250021 atgccgatgg ctgaagtgac gatgccggct tatctgccga tcgggttcca ctcttactct 250081 tcagcgattt caaattatat cccgcatatt tcgcgaatgt tctatgatgc attgaaaaac 250141 ggaaatgacg agcttgtgaa ggaactctat cggcatgtga ttctgccgat caacgacatt 250201 cgcaaacaac gaaaaggcta cgccgtatcc ttgattaaag ccggtatgga aatcatgggt 250261 ttgaatgtaa ggaatacagc cagaccgcct gtcggcccgg ttgaaaaaga tcattatcag 250321 caattggaag caattttgaa gcaggcggct gaccgttttc cgaaaaaagc cgcgacggtt 250381 tgaccagaaa aaacacgaaa ggggcaatgg gcatgtctgt gatcacggaa caaaacacgt 250441 acctcaactt tattaacgga gagtgggtta agtctcaatc aggcgatatg gtcaaagtcg 250501 aaaaccctgc cgatgtgaat gatattgtcg gatatgtaca gaattcaacg gctgaagatg 250561 tggaacgtgc cgtcaccgcc gccaatgaag ccaaaacggc ttggagaaag ctgacgggtg 250621 ccgagcgcgg ccaatactta tacaaaacag cggatatcat ggagcagcgc ttggaggaaa 250681 tcgccgcctg tgcaacgcgt gaaatgggta aaacattgcc ggaagcgaag ggagaaacag 250741 cccgggggat tgccattctg cgctattacg ccggagaggg catgcgaaaa acgggtgacg 250801 tcattccgtc tactgacaaa gacgcgctca tgtttaccac ccgtgttccg ctcggtgtgg 250861 tcggtgtgat ttctccgtgg aacttcccag tggcgattcc gatttggaaa atggcgccgg 250921 cattggtata cggcaatacc gttgtcatca aaccggcgac agaaacagct gtgacatgcg 250981 cgaagatcat tgcctgcttt gaggaagcgg ggctcccggc aggggtcatc aatttggtga 251041 caggcccggg ttctgttgtc gggcaggggc ttgctgagca tgacggtgta aacgccgtta 251101 cgtttaccgg ttcaaatcaa gtcggaaaaa tcatcgggca agccgcttta gcgaggggag 251161 ccaaatatca gcttgagatg ggcggcaaaa accctgtcat cgtagctgat gacgctgacc 251221 ttgaagctgc ggcagaagct gtcataacgg gggccttccg ttcaaccggc cagaaatgca 251281 ccgcgacaag ccgtgtcatc gtacaaagcg gaatttacga gcgctttaaa gaaaaactgc 251341 tccagcgcac aaaagatatt acaatcggag acagcttaaa agaggatgtc tggatgggac 251401 cgatagccag caagaatcag cttgataact gcctgtcata cattgagaaa ggcaaacagg 251461 agggcgcttc ccttttaata ggaggagaaa agctggagaa cggaaagtat caaaacggct 251521 attatgttca gcctgccatc tttgacaatg tgacatctga gatgacaatt gcccaggagg 251581 aaattttcgg tccggtgatc gccttgatca aggtggactc gatagaggag gcgctgaaca 251641 tcgccaatga tgtgaagttc ggtttaagtg catccatctt cacggaaaac atcggccgaa 251701 tgctttcttt cattgatgaa atcgatgccg ggctggttcg gatcaatgca gaaagcgcag 251761 gtgttgagct gcaggcgcct tttggcggca tgaagcagtc gagctcccac tcccgagaac 251821 agggtgaggc agcgaaggac tttttcacag cgatcaaaac tgtttttgtg aagccgtaat 251881 ggtgctggaa agaggcgtgc gtctctttcc cggtttatca caaccagcat atgattctct 251941 actttgaaaa ggagaagata ctatgaaaaa agactttgcg agtgttactc cggcgggcaa 252001 aaaaacgtcc gtgcgctggt tcatcgtgtt tatgctgttt cttgtgacct ctattaacta 252061 cgcggatcga gcgacgcttt ccatcaccgg agattccgtc cagcacgatt tgggattgga 252121 ctcggtcgcc atgggatatg tcttttctgc ctttggctgg gcctatgtca tcggacagct 252181 tccgggcggc tggctgctgg accgttttgg ttcaaagact atcattgcgt taagcatctt 252241 tttctggtcg ttttttacgt tgctgcaagg ggcgattggc tttttctccg ccggcacagc 252301 gattatcctg ctgtttgcac tgcgttttct ggttggttta tcagaagcgc cttcatttcc 252361 cggaaacggc agagttgttg cctcatggtt tccaagctcc gagcgcggga cagcttcagc 252421 cttttttaat tcagcacaat acttcgcaat cgtcattttt tctcctttaa tgggctggct 252481 tacccactct ttcggctggc attccgtttt cgttgtcatg ggtattgcag gcattcttct 252541 ggctgtcatc tggctaaaaa cggtgtatga accgaaaaaa catccgaagg ttaatgaagc 252601 tgagcttgcg tacatcgaac agggcggcgg gctgatttcc atggatgaca gtaaaagcaa 252661 acaagaaaca gaatcgaaat ggccgtatat caaacagctg ttaacgaacc gcatgctgat 252721 tggcgtgtac atcgcgcaat actgtattac gactctcacc tatttctttc tcacatggtt 252781 tccggtatat ttggttcagg cccgcggcat gtctattctt gaagctgggt ttgtcgcttc 252841 cctgccggcg ctgtgcggat ttgccggcgg cgtgcttggg ggcattgtgt cagacatctt 252901 actcaaaaaa ggccgttcac tgacctttgc aagaaaagtg ccaatcattg ccggcatgct 252961 gctgtcttgc agtatgattg tctgtaacta cacagattca gcatggctcg tcgttgtcat 253021 tatgtcgctc gcgtttttcg gaaaaggctt cggcgcattg ggttgggctg tcgtgtcgga 253081 cacgtctccg aaagaatgtg caggattaag cggcggtttg ttcaacactt tcgggaatat 253141 tgcctcaatt acaacaccga ttattatcgg atacattgtc aatgccactg gatctttcaa 253201 tggcgcgctt gtgtttgtcg gcgctaacgc gattgcggcg atcctcagct atttgctgct 253261 ggtcgggccg atcaaacggg tcgtgttaaa gaaacaagaa caagaccccg atcaatcgtt 253321 gcctgtctaa tatttatgaa agcgctttat aaagggagga aaatgcatga gttcaccgat 253381 acaagagcag gttcaaaaag aaaaaagatc gaatattccc tcaatttctg aaatgaaggt 253441 gattcctgtt gcgggacatg acagcatgct gctgaatcta agcggagcac acagcccgtt 253501 ttttacccgg aatatcgtaa tcttaacaga cagcagcgga aatcagggag tcggcgaggt 253561 gcctggcgga gagcatattc gccgcacact ggagctgtca gagccgcttg ttgtcggaaa 253621 atctatcggt gcgtaccagg cgatattgca aacggtcaga aagcagtttg gcgatcagga 253681 caggggaggg cgaggaaacc agacgtttga tttgcgcacc actgtgcacg ccgtcaccgc 253741 actggaagcg gctttgttgg atttgcttgg aaagtttctt caggaaccgg tcgcggcttt 253801 gctgggcgaa gggaagcagc gtgatgaagt aaaaatgctc ggttacctct tttacatcgg 253861 cgaccgaaat cggacgacct tgccgtatca aagcgatgag cagtcagatt gtgcgtggtt 253921 ccgtctgcgc catgaggaag cgctgacgcc ggaggccatt gtgcgtcttg ccgaatccgc 253981 acaggagcgc tatggctttc aggatttcaa attgaaaggc ggggtgctgc ggggagaaga 254041 ggaaatcgaa gctgttaccg cattatcgaa acgttttcca gaggcaagga tcactcttga 254101 tccgaacggg gcatggtcat tagaggaagc tattgcatta tgcaaaggaa agcaagatgt 254161 gctcgcgtat gcggaagatc catgcgggga tgagaatggc tactccgctc gtgaagtaat 254221 ggctgaattc cgccgcgcga cagggcttcc gactgcgaca aatatgattg cgactgactg 254281 gcgggaaatg ggtcacgcga ttcagctcca cgcggtcgat ataccgctgg ctgatccgca 254341 tttttggacg atgcaagggt cggtgcgggt tgcgcaaatg tgccatgatt ggggtttgac 254401 atggggctcg cactccaaca accactttga tatttccctt gcgatgttta cccatgtggc 254461 agcagcggct ccggggcgga tcacggcgat tgatacccat tggatctggc aggacgggca 254521 gcgattaacg aaacagcctt ttgagatttc ttctggctgt gtcaaggtgc cggataagcc 254581 tggactaggc gtcgatattg atatggaaca agtggaaaaa gcgcatgaga tctatcggaa 254641 aatgaattta ggcgcacgga atgatgcgat cccaatgcag ttcctgatca gcaactggga 254701 atttgaccgg aagcgcccgt gtcttgtgcg ataagtttga ttgtaaatat tgtcatatcc 254761 gctattttgt cttacaattg aacaactgaa gggagagttg ttcgtgtacg aaggtttaga 254821 ggatttgaaa gtcgatacag tcaatcggaa aacattagcc aagcaggtca tcgaacggat 254881 tgtccattta ttatcgagcg gacagttgag ggccggagac aaattgccga cagaaatgga 254941 actgatggac attttgcatg tcagcaggcc ggtgctacgg gaagcactca gttcacttga 255001 aacgctgggc gtcattacga gaaaaacacg agggggcaca tatttcaacg ataaaatcgg 255061 catgcagcca ttttccgtca tgcttgcttt ggccactgat aatcttccgg ctatcattga 255121 agcgcggatg gcgctagaac tcgggctcgt gacaattgcc gcggaaaaaa tcaatgagga 255181 agagcttcag cgtttgcaga agacgatcga cgatattgcc aacagcactg acaatcatta 255241 tggtgaagcg gataaagagt tccatcgaat tattgcgtta agcgccaata accccgtcgt 255301 tgaagggatg attcagtccc tgctgatcac ccatgcgaaa attgacagcc aaattccgta 255361 cagggagaga gatgtaacgg tcgaatatca caaaaaaatc tacgacgccc ttgccaaaag 255421 agatccgtac aaagcacatt accacatgta tgagcatctg aaatttgtcc gtgacaaaat 255481 tctaaaagga atggatgaaa aataatggtg agcaaccgca gttgaaacgt aagagctgcg 255541 gtttttttaa accaatttag aaaacgctta ctaaaatatg aggagtgatt ttcatatggc 255601 gatgaacctc aggaagaacc aagcccccct ttacatcaaa gtgcatgaaa tagataacac 255661 cgcgattatt gtaaatgatg gagggctgcc aaagggcact gttttctcat gcgggctcgt 255721 acttgaagag gatgttcctc aaggccataa ggtggccctc accgatctca atcaagggga 255781 cgagatcgtg cgttacggag aggtgatcgg atttgctgat gagacgatca aacgcgggag 255841 ctggatacgg gaagccctcg tgagaatgcc cgctcctccg gcgttagacg atcttcctct 255901 cgcaaacagg gtgccgcagc cgcggccccc acttgaagga tatacatttg aaggataccg 255961 aaatgcggat ggcagtgcgg ggacaaaaaa tatcctcggc atcacgacaa gtgttcaatg 256021 tgttgttggc gttttggatt atgcagtcaa acgaataaaa gaagagctgc tgccgaaata 256081 cccaaatgtc gatgacgttg tgccgctgca tcatcaatac ggatgcggcg tggcgatcaa 256141 tgcgcccgac gctgtcattc cgatccgcac gattcaaaat cttgcgaagc atccgaactt 256201 cggcggtgaa gtaatggtaa tcggattggg atgtgaaaag ctcctcccgg aaagaattgc 256261 ctccgaaaat gatgatgaca ttctatcgct ccaggatcac cgaggttttg cggcgatgat 256321 ccaatccatt ttggaaatgg cggaggaacg gttaatcagg ctgaacagca gaacccgggt 256381 gtcatgccct gtttcggatc tggttatcgg cctgcaatgc ggcggcagtg atgcgttttc 256441 cggcgtgacg gcgaaccctg ccgtggggta tgcggctgat ttattggttc gcgcaggtgc 256501 aacggttttg ttttctgaag tgacagaggt gcgggatgcc attcatttat taacgccgcg 256561 ggctgtcagt gaagaggtcg gacaatcgct gatcaaagag atgaagtggt atgacagcta 256621 tcttcggcgg ggagacgcag accgtagcgc aaacccgtca ccaggcaata aaaaaggcgg 256681 attatccaat gtggtggaaa aagcgttagg ttcggtagcg aaatcaggca caagccccat 256741 ctccggcgtg ctcggccctg gtgaaagagc aaagcaaaaa ggcctgctgt tcgcggcgac 256801 accggcaagc gattttgtgt gcggcaccct gcagctggct gcgggcatga atttgcaggt 256861 gtttacgaca gggagaggaa caccatatgg cctggctgct gcgccggttc tgaaagtatc 256921 gacgcggcat tccttatcag agcattgggc tgatttaatc gatatcaatg ccggccgaat 256981 cgcgacagga gaggccagta tcgaagacgt aggctgggaa atcttcagga cgattttgga 257041 tgtggcaagc ggccgcaaac aaacgtgggc agaccgttgg ggtcttcata atgatttgtg 257101 cttgtttaat cctgctccag tgacttgatt catgttttta tagcggaaag atggaatatg 257161 ctgtaaaatg aaaatcagcg tataggaaac ggaggggtta cagcatggca ttcattagat 257221 tccgagtgac acgaattcaa tagtgaacaa ctctcgcctg aatgcgagag aatcgggatg 257281 aatccgccta tgtatgagcc cttatatggt tatcaaaaaa gagggtggcg tgcctgccct 257341 tttttgtgcc ttcaagcatc ccttctctct actgcaggcc ggagcatgag aaaggggaaa 257401 tgggatgaca aaccttaacg aaaaacagct tatcactgag attgtcgggc ttgcacgcag 257461 ccaaggtttg acggttcatt ctgagaacgc gcaattgaat gaaaccggaa tggactttca 257521 agttgtattt gccaaggacg acacaggtat gccatgggtg ctgcgaaaac cgcggcgaag 257581 tgatgttgtg gaaagagcat ctgcagaagg cataacgctt gcctttctcc gcgcgaatct 257641 gactgctgat gtgccggatt ggagaattca tacaccggaa ttgatcgctt accccatgtt 257701 aaaaggaacg ccggctgctg gaattgactt ggaacaaaag caatatgtat ggaatatgga 257761 tcatcagccg ccgtcagacg actttgtccg cacacttgcc gacatactgg ctgaattaca 257821 tggcacggat caaatatctg ctgggcaatc cggaatagaa gtgataaggc cagaagattt 257881 caggcaaatg acagcagact ctatggttga tgtgaagaat aagcttggcg tatctacgac 257941 gctttgggaa agatggcaaa agtgggtaga tgatgatgca tactggccgg gtttctcttc 258001 tttgatacac ggcgatctcc acccgccgca tatccttatc gatcaaaatg gacgtgtcac 258061 aggacttctg gattggacag aagcgaaggt tgctgaccca gccaaggatt ttgttcttta 258121 tcaaaccatt ttcggagaaa aagaaactgc ccgtttgctt gaatactatg atcaagcagg 258181 cggccgaata tgggcaaaaa tgcaggaaca catctcagag atgcaggcgg cgtatccggt 258241 ggaaatcgcc aagctagctc tgcaaacaca gcaggaggaa cacatcaata tggcgctgga 258301 agcacttggt gtaacatcgg attaagaatt gacttcgttt catgaaccga gtattataaa 258361 ctctacaaat aatagaacgg attaacaatc gtgaggaaga gcaagtacgc atcagaatgg 258421 aggttcagag agtcggtggc aggtgtgaac cgatcctccc ctgatgccga atgggcttct 258481 gaattgcttt gctgaacgga tagtaggcga tgccgggttt ctctccccgt taccaagaga 258541 ggagtatcga aacataggtt ttctgtactt agagtgaacg gctgtatagc tgttaataaa 258601 ggtggtaccg cgagaccctc gtcctttgca taggacgggg gttttttgtg tttcttaaag 258661 gaggtgacgg ccaatgtacg atggctggtg gtggcatagc agatgagtta gaaaggagga 258721 tatcaaatgg tcattgcaac tgatgatctt gaggtcgcat gtcctaaatg tgaaagagcg 258781 ggagaaatcg aaggaacacc ttgcccggcc tgcagcggaa aaggtgttat tctgactgct 258841 caaggatata cgcttctcga ttttatccaa aagcatttga ataagtaaag gagaaaagct 258901 gagctgagat gagagcagaa gagcagagta agattcgtga ggccgcagca ggtacgattt 258961 ttttgctgat cggaacagtt tgttttgcgt ctaaatcgat ttggataaaa tgggcatacc 259021 aaatgggtgc tgagccagat gccgtgctgc tatacaggca gctgctggct gttccgctgt 259081 tttggctgat ttttttaata taccgtcctc caatgccaga cggtaagaaa aaaggagacc 259141 tatggaaggc ttgtggcgcg ggagtgtttt gtttttttct gtctcccttg cttgatttta 259201 tcgggctgaa ccatgtatcc gcaatggttg aacgtatatt gctgatgagc tatccgttgt 259261 ttgtgtttgg attcaccgcg tgtcgtgacc ggaaaatgtc ctcaattcag gaccttttcg 259321 cagttctggc ggtcatgttt gggcttttct tggcgctggg cggctggaat gctgagcttt 259381 tccaggcgaa tatgattgga gctgtattca ttttgttatc ttcggccgtc tatgctggtt 259441 atcttgtcct ttccgggcat ctcgtccatc aaatcggagg gatccgtctc aatgcatacg 259501 ggatgacagc tgctggagct gccatgatgc tttacacagg gataaaatcg gcggctggca 259561 tgaatacgcc aatggcagca tatccgcttt ctatgtatgg tttgttcgca gtaattgcag 259621 tcgttaccac agtgattcca tttgtgctaa tgcttgaggg cataaaacga atcggggcac 259681 agcgagccgc cgccatttca atggcagggc ctatcctgac gattttctat ggagctttat 259741 ttctcggtga acggctcggg ctcattcaag tcattggatg cggtggcgta ttttttgtca 259801 ttacgggcat ggaatacagg aagctgaaaa caggaaaaaa agaataattt ttataaaaca 259861 cacacgtttt tcaattacaa taagtgtaat tacgtgtgtg ttttttgatt ttgtaaaggt 259921 taggtgagga gatgcagcgc atattgcttg tagaagacga ccactcaatc agtgaaatgg 259981 tggatcatta tttaacaaaa gaaggctttg gaattgtgca tgctttcgac ggagaagagg 260041 gcatccggct gtttcagcag ggttcatacg atttggtcct ccttgatatc atgctcccga 260101 agctgaacgg catggatttt ctgaaaatca tccgggaaaa aagcaatata ccggtcttaa 260161 tgatttcggc aaaagatgga gatgtggaca aggcattggg actgggcttt ggggcggatg 260221 attatatcgc caaaccgttt tcgatgattg agctgacagc ccgagtaaaa gccgcgatac 260281 ggcgggcgac gcaatattcg gcagaggagc cggctgtgaa taaggtgatc cggattcacc 260341 agcttgcgat agatatagac aatgtttccg ttttgaaaaa cggagagccg ctccagctga 260401 cgtcaacaga atggcagctg ctgtgcttat ttgcatcaaa tcctaaaaaa gtgtttacga 260461 aagaacaaat ctaccgttcc gtttggaatg aagagtactt tgatgatcag aacatcatta 260521 acgtacatat gcggcggctc agagaaaaga ttgaggatga cccctcctcc cctcaatata 260581 ttaaaacgtt atggggcatc ggttataaat taggagagtt ttagaatgac agtgctatgg 260641 gtggccgctg tcatcgctct ggcgtgtctg aatgtgattc aattcataat gaaaaagaag 260701 cgggacggga atctggctta cacggctgac cagcttagct acatgctcag ccgggattcg 260761 gcaggacaaa ttttgcttcc tacagacgat catgcgctca aagacttgct tgttaacatc 260821 aatcttatcg ttgagaatcg tcagcagatc agcgcccaat ttgccaaaac agagcaatcc 260881 atgaagcgga tgctgaccaa tatgtcgcac gacctgaaaa cgccgttaac ggtcattctc 260941 ggttatattg aagccattca aagtgacccg aacatgccgg acgaagagcg ggaaagattg 261001 ctggggaagc tccgccagaa aacaaatgaa cttattcaga tgatcaattc cttttttgat 261061 ttagcgaaat tagaatctga agataaagag atcccgatca ccaaagtaca tatgaacgac 261121 atatgcaaac gaaatatcct gcactattat gacgctgttc agtcaaaagg ctttcaagca 261181 gccatcgata tccccgatac gccggtgtat gcgcaggcga atgaagaggc tctggacaga 261241 atcctgcaaa acctattgtc caatgcgatt caatatggcg cggccggcaa gttaatcggg 261301 ctgacgctgt cttatgatga gaggaacatc gccatcaccg tatgggatcg cggaaaaggg 261361 attagtgaaa ccgatcagca gcgggtgttt gagaggctgt acacactgga agaatccaga 261421 aataaagcat ttcaaggaag cggcttgggt ttaaccatca caaaacggct tacagaaaaa 261481 atgggaggca tcatatccgt ccaaagcaag ccgtacgaac ggactgcatt tacgatcaca 261541 ttgaaacgca tgacatatta atcgtaagaa tttcttaagg tttgagaaat aaaaatgaca 261601 gggctcgccg ctacaataga aaacaggaaa agagagggaa ggagaaacaa agttgactta 261661 tatcgtacaa acaaacgggc tgaccaaaac atatcagggc aaagaggtcg tatccaatgt 261721 cagcatgcat attaaaaaag gtgaaatcta tggctttctc ggcccgaacg gcgcggggaa 261781 aacaaccatt atgaaaatgc tgacgagcct tgtcaaaccg acaagcggtg aaatcatcat 261841 ccttgggaac aagttcaccc acacgtcata tgaggtgctg gggaacatcg gcagcatgat 261901 tgaatatccg attttttatg aaaacctgac agctgaagaa aatttagatc tgcattgtga 261961 atatatggga taccacaata aaaaagccat acaagaagtg ctggatatgg tgaatttaaa 262021 acaaatcgac aaaaaacccg tcaaaacctt ttccctcggg atgaagcagc gccttggaat 262081 tgcgcgtgcc atcctcacga agccggacct gcttattctg gatgagccgg tgaatggtct 262141 tgaccctctc ggcattaaaa agatcaggca attgtttcaa gtgctgagca aagagtacgg 262201 gatgacgctg ctgatctcaa gccacctgct gggtgaaatc gaacaaatcg cggacacaat 262261 cggcgtcatt cgggacggca ggctgcttga agaggtatca atggaggatg tcaggggcca 262321 gaacactgaa tacatcgagc ttgtcacgcc gaatcagaca agggcctgct ttgtgctgga 262381 gaaagagctg caattaacca actttaaaat attaaatgag aaaacgattc gaatttacga 262441 ggctgaagcc tctcaggctg ccatatccaa agcattgatt ttaaatgatg tagacattga 262501 atcaatgaac aaaaagtata cgtcgctgga ggattatttt atcaaattga tcaacggcaa 262561 tagcatcagt gcgtaaagga ggagagacac gttgatgaat ttgatcagaa tcgaattaag 262621 aaaaatgaaa atgggctggt atatcagagg tgccctcatt gccaacgtga tcattatggg 262681 ttttatgtgg ctgatcagtt attccgaaaa agccgatggc ggggtttcgt tccaaagtac 262741 ggatgaagca ttcctcatca tcggcacctt cgtcagagcg gtatttatcg tatttggcgc 262801 tgtgctgatc gtaaaattgg tgatttcgga atataaaaac aaaaccattc ttgtgatgtt 262861 cacgtacccg atcagccgta aaaagctgct caccgctaag ctcatgatcg cgggcggact 262921 gacgtttatc acgattttac tttcaaatat actcatagcc gccggtttct tttggctgaa 262981 ctcgatctgc catttcatac cgggagagct tacttccgag atcatttctc aacaggcggt 263041 caaaatggcg gttttcgctt ttggcgccgc tggaaccagt ttagttccca tcttttttgg 263101 gatgcgtaga cactcggttc cggcgaccat catttcatct gtagtaattg tgatgctcat 263161 cagctcaaca agtccgggct tctcgatttc atctgttgtg tatatcccgt tatcgttagc 263221 ggcattcggt ttgttctttt cctacatggc gatcaggaat gcggacaagc aggatgcgta 263281 aacaaaggcg cccaatatgt ataaaaggcc gatgctgtca gcaccggcct ttccattatg 263341 agtctgttct tgtttcaaga taatgcttct tgccaatctc tttgctcatc atatagaaat 263401 ggaagcaata ttcaccgatt gccatgacga tcgcgccgaa taaagccgcc aatgcaactt 263461 caccgccagt catccccata gaaagcggca tgcccatcag ccagatcacg agaaaggcca 263521 aaccaaaatc agccaaagtt gcaatcatat tattccattt cggcaataca taaagatcgc 263581 ccagcaaata agaaataacc cctaacacaa tcgtcattag cagcgtatca ccaaacgtga 263641 aaccaaagcc cagaccaagc accagataca acacaataat cgtcataata cctttaatag 263701 cgagcgcttt cacatgtgtc attacaattc ctccttttgt catttgattt gttatgtata 263761 attcctcaaa tgtaaaaagt taaaccttat ttcttttcgg aggcgggtgc aaatctgctg 263821 gggagaggtc aatgatgtga atccaggaat tgaggctgcg gcgcttcgac agcggaaacg 263881 tgaagcttgt actgcaccgg acgctgcttt gatgcccaac agcccattat gtttgctgtt 263941 tttagatgaa taaatttaaa aacttctcct gtccctccgt catcacttct gaagtaatga 264001 aatatgatga aaagagatca aggggaggtg acgtgatggc ggtcgtgaga gcaacgagtg 264061 cggatgtcga tttgatggca aggctgctca gagcggaagc ggaaggcgaa ggcaagcagg 264121 ggatgctgct tgtcggcaac gttggaatta atcggctgcg ggcgaattgc tcagatttta 264181 aaggcctccg caccatcagg cagatgattt atcagccaca cgcgtttgag gctgtgactc 264241 atggatattt ttatcaaagg gcgcgagata gcgagcgtgc ccttgcacgc cggtcgatta 264301 atggtgaaag gcgctggcct gcaaaattta gtttatggta cttcaggccg cagggggact 264361 gtccagccca gtggtataac cagccgtttg tggccagatt taagtcacac tgcttttatc 264421 agccgacggc ggagacgtgt gaaaatgtat ataacacatt ttagagacag gacaccgttc 264481 aaattgaacg gtgtttttct ttgaaaagat gcaatgcaaa atattcctgt gagataatca 264541 aagaaaaaag agctgacgga gatgacagaa tggcaacaat tgacctgcaa aagaaaagtg 264601 taaagatcgt actggagaaa aagcagttaa cgaaggtgac ggctcgtgtt ggactggttc 264661 ttgatattac gggatcgatg agaccgctct acaaaaacgg gacggttcaa aatgtggtgg 264721 agcggatttt ggcagtggct gatcagtttg atgataacgg tttgctggat gtatgggtgt 264781 atgataatga attttcccga ttaaagccag tttcagaaaa ggatttttcg ggctatgtcg 264841 atcgtgaaat tttaaataat gaccgcttgc ataaattcgg cagaaatgat gagccgccag 264901 tcatgaagga cgtgctgcgc aaatatgtta cggaggaacc gagctcgtat cctgctttca 264961 ttgtttttat caatgacggg ggctgtaaaa agtcaatcaa accgataatt gaagcttctt 265021 ctgataaacc ggtgttctgg cagtttgtcg gcatcggaaa cggaaacttt gattttctca 265081 ataaactgga tacgttagaa gggcgtgtca ttgataacac gaacttcctg catatcgaag 265141 agattgaccg catttctgat gatgagcttt atgatgctct gcttgctgaa tttccatttt 265201 ggctgaaaga agcgaaggaa aaagggattg taagagaaca agagcctcct gctgaaaagc 265261 cgaaaaagaa gggctttttc agcagattgt tttcgaaata actgataaag agcactgagt 265321 cattctgcga aatggctcgg tgtttttgtt tttttaagat catgtgaaga aaaataggcc 265381 gaatgggcgg cttgcaaacg acaggatatg cagaaaacgc gtcattcagc cagctttcgg 265441 catgtttcag cagcaggctt gtgagggaag acctgttttt aatgttcagc gcttacaatc 265501 agttcacact tcttcacagt cgtttaacaa tgatttccta taatggagac gatcaatgag 265561 gagagagggg atcttgaatg gcatacgaca gtcgttttga tgaatgggta cagaaactga 265621 aagaggaaag ctttcaaaac aatacgtttg accgccgcaa atttattcaa ggagcgggga 265681 agattgcagg actttctctt ggattaacga ttgcccagtc ggttggggcc tttgaagtaa 265741 atgctgcgcc taacttctca agctatccgt ttacattagg ggtagcgtca ggtgatccgc 265801 tttctgacag tgtcgtgctt tggacacgtc tggcaccaga tccgctgaat ggcgggggaa 265861 tgccgaagca agcagtgcct gtcaaatggg aggtcgcaaa ggatgagcat ttccgcaaaa 265921 tcgtaagaaa aggcactgaa atggctaaac caagtcttgc ccattccgtt catgtggaag 265981 cggacgggct tgagccaaac aaagtgtact attaccgttt caaaaccggc catgaactaa 266041 gccctgtcgg aaaaacaaaa acactgcctg cccctggcgc caatgtgccg caaatgacct 266101 ttgcatttgc ttcctgccag caatatgagc acggatatta tacggcctac aagcatatgg 266161 caaaggaaaa gcttgatctt gtcttccatc tcggtgatta catatatgaa tacggcccaa 266221 atgaatatgt atcaaaaaca ggcaatgtcc gcacgcacaa cagcgcggaa atcattacgc 266281 tgcaagacta tcggaaccgt cacgctcaat accgttctga cgccaatctt aaagctgcac 266341 atgcggcatt cccttgggtt gtaacttggg atgaccatga agttgaaaac aactatgcca 266401 ataaaatacc tgaaaaagga cagtcggttg aagcattcgt gctccgccgc gcggcagcat 266461 accaggcata ctatgaacat atgccgctcc gcatttcctc tttgccgaat ggcccagata 266521 tgcagctgta ccggcacttt acgtacggaa acctggcgtc cttcaatgtg cttgataccc 266581 gccagtacag ggacgaccaa gccaataacg acggcaataa gccgccttct gatgaatcgc 266641 gcaatccgaa tcggactctg cttggaaaag aacaggagca gtggctcttc aacaatttgg 266701 gcagctcgac agcccactgg aatgtgctgg cgcagcagat tttctttgcc aagtggaatt 266761 tcgggacaag cgcaagcccg atctacagca tggattcgtg ggacggctac ccggctcagc 266821 gcgaacgggt tatcaatttc attaaaagca aaaatctgaa taatgttgtc gtactgacag 266881 gtgatgtaca cgcaagctgg gcatcgaatt tgcatgtcga tttcgagaag acaagttcaa 266941 aaatattcgg agccgaattt gttggaacct cgatcacttc cggagggaac ggagcggata 267001 agcgagcgga tacggaccaa attttaaaag aaaatccgca catccagttc tttaacgact 267061 atcgcggata tgtccgctgt acagtgacgc ctcaccagtg gaaagccgat tatcgggtga 267121 tgccatttgt gaccgagccg ggcgcagcca tttccacgcg ggcttcattc gtttaccaga 267181 aagaccaaac cgggttgaga aaggtatcat ccacaacaat ccaaggcggg gtgaagcaat 267241 ccgatgaggt cgaagaggat cgtttctttt cgcacaacaa agcccacgaa aaacaaatga 267301 ttaagaagcg tgcaaaaatc acgaattaag gagtggaaat tatgttttca aacattggaa 267361 taccgggctt gattctcatc ttcgtcatcg ccctcattat ttttggccct tccaagctgc 267421 cggaaatcgg gcgtgccgcc ggacggacac tgctggaatt taaaagcgcc acaaaatcac 267481 ttgtgtctgg tgatgaaaaa gaagagaaat cagctgagct gacagcggta aagcaggaca 267541 aaaacgcggg ctgaatgctg atgaggcaga caccgggtct gcctcttttt ttatgaaagg 267601 gagggctttt ttgaatggat aaaaaagaaa cccatctgat cgggcattta gaagagcttc 267661 gccgccggat tatcgtcacc cttgcggcat tttttctatt tctcatcacg gcttttttgt 267721 tcgtacagga catttatgac tggctgatca gggatttgga tggaaagctg gctgtgctag 267781 gaccgagtga aatcctctgg gtgtatatga tgctttccgg catttgtgcc attgcggctt 267841 ctatccctgt tgccgcgtac cagctgtggc gtttcgttgc accggcgctg actaaaacgg 267901 agcgcaaggt gacgctcatg tacataccag gtttatttgc gttgtttttg gcgggcatct 267961 ccttcggata ctttgtcttg tttccgatcg tgctcagctt tttgactcat ttatcctccg 268021 gccactttga aacgatgttt acggctgacc gctactttag gtttatggtg aatttgagcc 268081 tgccgttcgg cttcttgttt gagatgccct tggtggtgat gtttttaaca aggctgggca 268141 tcttaaatcc ttacagactg gccaaagcga gaaagctttc ctattttctg ctgattgtcg 268201 tgtccatatt gattacaccg cctgatttta tttctgattt tctcgtgatg atcccgcttc 268261 ttgtcctgtt tgaagtgagt gtcaccctat cggcgtttgt ctacaaaaag aggatgaggg 268321 aagaaacagc ggcggccgct tagtgcagcg taccacccgg tgacttcaca tcctcatcat 268381 attgtgcggc cgtaacagcg gcgattctca atgcccggac aatcgtgtcc aggctgaggc 268441 tcggcgctgt tttgtcgatt gtttgctgcg gaatgtaagg aatatgaata aaaccgccgc 268501 gaatgtgtgg ggatgtccgg ctaatgtgat ccattaaccc gtagaacaaa tagttgcata 268561 caaaggtccc cgctgtgtag gaaaccgcag ctggaatgcc gtgttccttc atcttagcag 268621 tcattcgttt cacgggaagc cttgtccagt aagcggcggg cccatctgga gaaatctctt 268681 catcaatcgg ctgatgtcct tcgttatcgg ggattcgcgc atctgcaagg ttgattgcca 268741 ctcgttccgg tgtaatctgc atccgtcctc ctgcttggcc gacacaaatt acgatatctg 268801 gctgatgttt ttgaatggct tggcgcagag tgtccagagc ggatctaaag acggttggaa 268861 tttgttccgc tgtaataatg gcttcttctg tctcgaagcc attaagccgt ttcgccgctt 268921 cccatgatgg attgacggtt tctttgtcaa aagggtcaaa gcctgtgatc agcacttttt 268981 ttctcattct cccatctcct ttttctttta ttctattgtt tatttatggg tttttcatca 269041 aaataatgta aaggagtgaa tcataatgga gcatttgccg gagcagtatc gccagttatt 269101 cccaaccttg cagacgcata cgatgcttgc cagctgttct cagagcgcat tggcagagcc 269161 tgtatcaagg gcgatccagg attattatga tagcctgctg tataaaggga cgaactggaa 269221 agaagcgatt gaaaaaacag agtttgcgag aaacgagttt gcaaagctga tcggggctga 269281 accggatgaa gtggcgattg tgccgtcagt ttctgatgca ctggtttctg tagcatcgtc 269341 cttaactgca tttggaaaga agcacgttgt atatacagat atggattttc cggcggtgcc 269401 tcatgtttgg caggcacact ccgattatac cgtatccgtc attccatcaa tagacggcgt 269461 gctgccgctt gaacaatatg aaacgcatat ttcggatgaa acagtactga cgtgtgttcc 269521 tcacgttcat tatcgtgacg gctatgttca ggatataaaa gcgattgccg agatttctca 269581 gagaaagggc tctttattgt ttgtagatgc ttatcaatca gccgggcata ttcccattga 269641 tgtgaaggaa tggggcgtag atatgctggc agcaggcacc cggaagtatt tgctcggcat 269701 accgggtgtg gcgtttcttt atgtgagaaa ggagctggct gacgcactga agccgaaagc 269761 atcagcttgg ttcggaagag agagcggatt tgatggggct tatgcaaaag tcgcgcgccg 269821 ttttcaaacg ggcaccccag cttttatcag cgtatacgca gctgcagcgg ctttatcgct 269881 gctgaatcat attggggttt ctcatatcag ggatcatgtg aaaacgatct gtgccgatgc 269941 agttcaatat gccgctgaaa aaggcctgca gctggcggcg gcacaaggtg ggattcagcc 270001 gggcatggtt gcgatccggg atgagcgggc atcggaaacg gcggggttgc tgaagaagaa 270061 aaaagtgatt tgcgcgccgc gggaaaatgt tatccgtctc gctccccatt tttataatac 270121 gaaggaggaa atgcggcacg cgattgatga aatcgcggcg aaaacgatcc acaagtaaac 270181 atgaaaaagc ccctgaacac tagtcagggg cttttcatat taatgatcta ctttaacgcg 270241 tttcataaag aaagcgccaa ttaaaccgat aatggcaaca atcattgcaa acacaaatgc 270301 gtgctgtacg cctgctgtca aagcttgcgg gatgactgcc ggatcggcag ggtttttaac 270361 tgtactcata taatcatgct ggcctgcagc cataatgctg accgcaaccg ctgttccgat 270421 agcgccggcc atttgctgca gcgtgttcat aatggcggtg ccgtctggat aaaattcacg 270481 cggcagttgg tttaaaccgt ttgtctgtgc aggcatcatg atcatagaaa tcccgatcat 270541 caagcaggtg tgcaggatga taatcagcac agctgttgaa gtggtcgtga catttgagaa 270601 gaaccatagt acaacggtga caatcacaaa tcccggaatg acaagccatt tcggcccgta 270661 tttatcgaac aagcggcctg taacagggga cataaatcca tttaaaatac cgcccggcaa 270721 gagaacaaga ccagatgcaa atgcagtgag gactaagccg ccttgcagat acatcggcag 270781 aagcagcata gatgacagaa tgaccatcat acaaatgaac accatgatca cacccaaaat 270841 aaacatcggg tatttgaacg cacggaggtt catcataggc tgcttcattg tcagctggcg 270901 gattgaaaat aagataaggc cgacaacgcc gacaatcagc gacacgataa cagtcgggct 270961 ggaccatccc ccggagcctt cacccgcgtt gctgaatccg aatacaatgc cgccgaagcc 271021 aatcgtcgac aggatgatag acaatacatc gattttcggc tttgtcgttt cagatacatt 271081 ttgcatatat gcgataccga aaacaagcgc cagcacaagg aatggaagag agatccagaa 271141 aatccagtgc cagttgagat gctccagaac caatcctgag aaagttgggc cgatggcggg 271201 cgcgaacata atgacaagcc cgatcgttcc cattgcggca ccccgtttat gaggcgggaa 271261 aatcaccaag attgtgttaa acatcagcgg cagtaaaaga ccggttccaa gtgcctgaac 271321 gatccttgcc gctaataaaa acgagaagct cggcgcaagc gccgcaatga atgtacctaa 271381 aattgaaaag ataagtgaca cggtaaaaag ctgtcttgtt gtgaaccact gcaacagcag 271441 tcctgaaaca ggaacaagga taccgagtac aagcaggtag cccgtcgtta accattggac 271501 ggttgccgct gtaatgttca attccttcat aaggtcggtt aacgcaatat tcagcgctgt 271561 ttcactgaac atgccgataa aaccggccaa cagcaaggaa atcataatcg gcatcacttt 271621 gtattgctga gatgctttag ctgttgtttc caaaatcatt tcccctctct atcaactgca 271681 tgtagtatgt cgtttttttt atctcttcag caggtcagga atgcagctgg agatatgaag 271741 gagcggcgta ctgttttttg ccgtcaaaga taaaaggatg ccgccttcaa tcatcgcgtt 271801 aaccacagtg ctggcttctt ttgcacggct ctcgctgcag ccagtctgcc gcagtttttc 271861 ctcatacaca gaggcccatt ctttgtaggc ttcatgacag gcttcgcgca acggttcgct 271921 tttcaatgac gtctcagccg ctagcaagcc cacaggcaag ccttcaatgt cttccgtaca 271981 tgaaaactgg caggagagct ccttcaaaaa ggcttgaatg ccttccgctg gatcggtgca 272041 ggcttccatg cagtccgcga ttttctgacg gatatactcc ttcatctcat tcacggcttc 272101 gatcgcaagc tgttctttac ccccgggaaa gtggtagtaa agagagcctt taggcgcgcc 272161 gctttccttt ataatctggt tcagccccgt gccgtaatac ccttgcagct gaaaaagccg 272221 ggtagctgcc gaaaggattt tctcacggga atctccataa ctcataacat tcccacctta 272281 ctgaattgca atcaaaaata tagtgactgg tctattatct tgattcaatc atcaattgtc 272341 aagaaaaatt cattgtatga aaagacaaaa aaagaaggat atgacaacaa aaaatactga 272401 gagaaaagct gactgatctt ttgactgaat agataaaatg tacaatgatt aatcatcata 272461 tggatgtaag gagagaaata gatgaaaaaa caacgaatgc tcgtactttt taccgcacta 272521 ttgtttgttt ttaccggatg ttcacattct cctgaaacaa aagaatcccc gaaagaaaaa 272581 gctcagacac aaaaagtctc ttcggcttct gcctctgaaa aaaaggatct gccaaacatt 272641 agaattttag cgacaggagg cacgatagct ggtgccgatc aatcgaaaac ctcaacaact 272701 gaatataaag caggtgttgt cggcgttgaa tcactgatcg aggcagttcc agaaatgaag 272761 gacattgcaa acgtcagcgg cgagcagatt gttaacgtcg gcagcacaaa tattgataat 272821 aaaatattgc tgaagctggc gaaacgcatc aaccacttgc tcgcttcaga tgatgtagac 272881 ggaatcgtcg tgactcatgg aacagataca ttggaggaaa ccgcttattt tttgaatctt 272941 accgtgaaaa gtgataaacc ggttgttatt gtcggttcga tgagaccttc cacagccatc 273001 agcgctgatg ggccttctaa cctgtacaat gcagtgaaag tggcaggtgc ccctgaggca 273061 aaagggaaag ggacgcttgt tgttcttaac gaccggattg cctcagcccg atatgtcacc 273121 aaaacaaaca caactacaac agatacattt aaatcagaag aaatgggctt cgtcggaaca 273181 attgcagatg atatctattt taataatgag attacccgta agcatacgaa ggacacggat 273241 ttctcggttt ctaatcttga tgagctgccg caggttgaca ttatctatgg ataccaaaat 273301 gacggaagct acctgtttga cgctgctgta aaagccggag caaaggggat tgtatttgcc 273361 ggttctggga acgggtcttt atctgatgca gccgaaaaag gggcggacag cgcagtcaaa 273421 aaaggcgtta cagtggtgcg ctctacccgc acgggaaatg gtgtcgtcac accaaaccaa 273481 gactatgcgg aaaaggactt gctggcatcg aactctttaa acccccaaaa agcacggatg 273541 ttgctgatgc ttgcgcttac caaaacaaat gatcctcaaa aaatccaagc ttatttcaat 273601 gagtattgaa gaaaagaagg cgaataagcc ttcttttttt tggcttttta ggaccaataa 273661 tgacctctga atcttaaaat ttctttaaaa ataagccaaa attacccttt acttaattaa 273721 tttggtaacg taatataatt ggagaatttg ttacaaaaaa aggaggatat tatgaaattt 273781 gtaaaaagaa ggatcattgc acttgtaaca attttgatgc tgtctgttac atcgctgttt 273841 gcgttgcagc cgtcagcaaa agccgctgaa cacaatccag tcgttatggt tcacggtatt 273901 ggaggggcat cattcaattt tgcgggaatt aagagctatc tcgtatctca gggctggtcg 273961 cgggacaagc tgtatgcagt tgatttttgg gacaagacag gcacaaatta taacaatgga 274021 ccggtattat cacgatttgt gcaaaaggtt ttagatgaaa cgggtgcgaa aaaagtggat 274081 attgtcgctc acagcatggg gggcgcgaac acactttact acataaaaaa tctggacggc 274141 ggaaataaag ttgcaaacgt cgtgacgctt ggcggcgcga accgtttgac gacaggcaag 274201 gcgcttccgg gaacagatcc aaatcaaaag attttataca catccattta cagcagtgcc 274261 gatatgattg tcatgaatta cttatcaaga ttagatggtg ctagaaacgt tcaaatccat 274321 ggcgttggac acatcggcct tctgtacagc agccaagtca acagcctgat taaagaaggg 274381 ctgaacggcg ggggccagaa tacgaattaa tgaaaaacaa aaccttgaag aatgctattc 274441 ttcaaggtta ttctgctttc agcacaatgg ttttcgcagc catatcatga acggtttgtt 274501 ttttcttcgt aaatgcggca gtcaaataga tcaggcggga gaacacatgc acccacgcta 274561 tcaggtaacg gacaatggct tgcgggaagg atattttttt atatgtttcg tccctcacga 274621 tttgcagccc gatgattttt ttgcctagtg tgcccttcca atttgtcagc ggcatcagca 274681 aagggtacac aatcagcatc aatatggcga caataatgac accggcggac ccatcgccaa 274741 acgtaaatcc ggctgccaaa atcactgctg cggcaatgat tacatcaagt aaaagagcgc 274801 aggcgcgcag catgaaacca gctagttcca atagaaacac tccttaaaat gttaaataaa 274861 cacctaatga ttgtaaaaaa gaagggccta aagtgggaat aggtgataag ccttaaatca 274921 caaaagttgg tgaaaatgtc ataggtaaat tggcataatc agccagctta tcacattacc 274981 aaattctttt ttagcccgaa accaagccct cagaagttat ttttgttaaa atagaaaagt 275041 tacaacagaa ttcggagggt ttattgtggg aaaagtgaaa cgaaatgccc cttgcccatg 275101 cggcagcggc aagaaatata aaaaatgctg cggaagtaaa gttgtcgact tcccggcgga 275161 actagcggca aaagaagcga aacaaattca ggaagactta gtggagtatg ccttcacagt 275221 acatagagaa agcatttcag gctttatcaa ccagcatgat tttctttctg ctatggacag 275281 acagacgaaa gacatcagcg tatttaactt aggaatctgg ggaatcttct tccacccgct 275341 tgctggtgag aagacaatct tcgaagagta ccttcagaaa aaaggcgatt cgatcactcg 275401 tccgaaaacg cgtgagatcg tagaatcatg gcagagcatg acgcctgctt tattgctgct 275461 gaaggacctg aaggaaggca tcattcactt tgaagatgtc attacggcaa aacaattcga 275521 agtggaaatg gacgccagca atcaagacct tcctccagtg ggaagcctga ttcttggata 275581 cccaatccac gaagcggaaa aagcagaatt cttcatgcag ttcacgatct tcccggtgaa 275641 gagaacagaa gcgctgatca gcaaggtgaa gaaatatgcg gatgccgctg tgaaggacgg 275701 caaaacgccg gaggacttca tgaagcagga attcaacaac gttctgttcg cgttgttagc 275761 tgagaaagat gaagagccac aagcagagaa agcggaagta agcactgttg agtgggcaaa 275821 cgacttggag aaagaaaccg ctgcggctat tgaagaaggc atgagcgggg aagagtatcc 275881 gactgaattg atcccagctg ttattgacat ctggaaaaca ttctgcgaga aaaaatcacc 275941 tgtcatcaga aagccggaag cttttgcggc ggcagttgaa tattatgtaa acgcaatttc 276001 tcttaacggc gcgtccgttt cccaggctaa actggcgaaa aaatacggcg ttagcgcatc 276061 aacgatttcc agccgttaca aagaaattga aagcacgctg caagatgaag cagatcgttt 276121 tgcacaagcg ttatcctcat aatggaaaaa accttgaaaa gccaggcttt tcaaggtttt 276181 tttatttctg aaacggaatt ttgatttcta accggaagat ggggtggcgg taggtaaaat 276241 ccagcctgcc aaaagcgccc ttcaccagtt tttgaatgat atatgtgccc atgccttcat 276301 gagcgccgtt tttcgttgag cggccaaacg attgataaat tgtatcgagc acttttgggt 276361 ccatcccggg agtgctgttt tcacaagtca gtacataaag cccgctgcgc agtgaagtct 276421 ccagtttaat ctctgctttt tctcgggcct ccgccgcgct gtcgagcgca ttttctaata 276481 tgttgccgac caagctgacc tgatcagcag gcgaaaacgg aagggaagaa agcggtgtat 276541 gcatatgcag cgaaacactc acattcgagg cgcgggcttt ttctaaaaaa tcataaagca 276601 cccctgcaac gtacgcgttc tctcctttca aaaaacggtc atattggctg tattgatccg 276661 cccagttttg aatatatgct tgtgtatctg ccttgggctg agctgatttg attgcagtga 276721 tatgtttcat tgtgtcatga ttccggcttc tgacatcaat cagcatttga ttggcgtgct 276781 gttcagcttg agtcagctta tcaatttgat cagaaagcct tgcctgcaaa gcagactgtc 276841 cgatacggag cccttcacac cctgcaaata tcgcgattac acataatacc ggcatgatgt 276901 ctgtgccaat caacaccact cccaccgaca tcacttgaat caccgcaatc cacgcacaaa 276961 gccctgagga acagtgtttc cacacccgct tcgtattcca aatgtacaat cctgcagcag 277021 ctgcgcctaa agcagcggcg agccaagagg cggctgtgct gtgtgaaaaa gcagcagctc 277081 cctgataaca tatgaaacta aataaaatca gataaagaca ttgaaaaagg gtaatcacgt 277141 actaaactcc tcaaaaatag tagttttgaa aataatcaag ctgctgctta gtgatcatcg 277201 cttttttaga cgttccctca aaggaaactg tgaatgaatg cttggtataa gcggaaaaat 277261 gctttatgta atgaatgttg ataataaagg aacgatgcga acgaagaaaa tctttttcgg 277321 gcaggtcgcc tttaatatca tttaatgttt gatacgtttg cacctcttcg gcggttgtca 277381 caatcgtcgt cgaacgtccc gtccgttctg cgaaaataat atccttcttt tgcaggacgt 277441 gcatttcaga cttttgcttt atcaatatac gcccattcaa actcgtttcc gttttctttt 277501 tcaagtaccg gtcgaaggaa gcggccagac ggtcggcata gtacggcttc ataatataat 277561 catggacgtt caggtcaaag gcgtgaaccg cataaccgcc gtggccggta acaaaaatca 277621 catccacatc aagtgaatgg gatttgatca aatcagcaag ctcgtagcca gacatatggg 277681 gcatctcgat atcggcaagc agcagatcaa tgtctccgtt ctttacccgc ctgtaggctt 277741 ccttcgctga atcggtggaa aagacaattt cgacgtcctg cattctggac acgatcgctt 277801 ctaacttctc taaatctact cgataatcat ctacaagtcc gacttttacc attatcattc 277861 ccctagttac atagaatcat ctttattcta tcccatttca cgacataaaa agaactcttc 277921 gcgacaactt tatccaacta atccagcttt tcgtatatag tcattactag aaataaagat 277981 aagggagatt gtgacatgat tacactgacc gattgcagcc gcaggtttca ggataagaaa 278041 aaagtagtca aagcggtgcg agatgtaagc ttaacaattg aaaaaggaga agtcgtcggc 278101 attctcggag aaaacggtgc cggcaaaacg acgatgctga gaatgattgc ttccttgctt 278161 gaaccatcac agggtgtaat cacagtagac ggctttgaca cggtcaagca gccggctgag 278221 gtcaaacaaa gaatcggtgt cttattcgga ggagaaaccg ggctttacga caggatgacc 278281 gctaaagaaa atctccaata cttcggcagg ctgtatgggc tgaaccgcca cgagatcaaa 278341 gcaagaatag aagatttatc gaaacggttc ggcatgcgcg attatatgaa ccggagagtg 278401 ggcgggtttt cgaaaggcat gaggcagaaa gtcgccattg ccagagcgct gattcacgat 278461 ccggacatca ttttatttga tgagccgaca actgggcttg atattacgtc aagcaacatc 278521 ttccgcgaat ttatacagca gctgaaaaga gaacaaaaaa cgattctttt ctccagccac 278581 attatggagg aagtgcaggc gctctgtgac agtgtcatca tgattcacag cggagaggtg 278641 atttaccgag gggcgcttga atcactatac gagagcgagc gcagtgagga tttgaattac 278701 atctttatgt ctaagcttgt cagggggatt tcttaaatgc tgagccatat ttataaaaaa 278761 gaaatgatcg acgctttacg cgacagaaaa acgatattac tcacaatctt agtgccgatg 278821 attatgatgc ttggacttgt ctttttttat gaaagcatgc tgtccgacaa aggggagcag 278881 tacacgctgg ctgtcggcca ttcgcttccg cccgcactgg aaagcaagct taatgagatt 278941 gacgaaatca gcgtaaaaac atttgcaaag cctgaagagg cagttgatga aggaaaagca 279001 gatgcctatc tgaacgtccc gaaagagttc gactcatatg tcaacagcat gacacctttt 279061 aaggttgatg tttacggcaa ttcaatcgat caagggtcgt caaatgccat gcagcttgtg 279121 cagtctgcct tagatcagta caaaaatgaa attgtgcagc aacgtttaac aaataagcat 279181 attgatcaat cggtgatcca gccgtttaca attcagcaaa aggaagcgga tgaggagaaa 279241 gggacttccg ctattatgct ttccgccatt ctgcccatgc tgattctgac ttccattgtt 279301 tccggcgcaa tgccgatcgc tcttgatatc atggccggtg aaaaggaccg aaagtcaatc 279361 gaggcgctgc tattaacgcc agtcagcaga aacaaagtgc tggtcggcaa gtggcttgcg 279421 gtttccactt ttggcgtggc ttcaggtgta tttgctttgg tgtttttgat tttgtccacc 279481 gtgttattta ccgaaaattt aaaaacggcc ttccagctgg gagatcatat gtggagtgta 279541 atcggcgctt cagccttaat cattgtgctc tctgcattgc tgatatctgc gatggagctt 279601 ttcatcagca tcatgtccag ctcggtaaaa gaagcgcaaa gttatatgtc tctcgtcgtc 279661 tttctgcctg tgttcccgat gtttttcatc ttcagcaagg caccgaacca atttgactta 279721 tcatactttc tcatcccgtt tctgaacctg catgcgttat ttaaacagct tttattcggg 279781 atggttgacc cggctaccat tttgtctacg tcaggaacca tcgccgtgct catcgccatc 279841 ttctttttac tagccagagc ctgcttcctg aaagacaaat gggttcttcc aaaataaact 279901 tgcgaaagga gaaatacact ttctcctttt tgtatatcct gaaaaaagaa ggaaaataga 279961 aaaaggatat ctaatacaaa aagtgaccct gcactatttt tcatcaaaat tggtttcaaa 280021 ggagaaggaa caatggatca aacacgtaca ctcggcaaaa cgaagctgaa ggtgaagcgg 280081 atcggattcg gcgcgaatgc ggtcggcggg cataatctat ttccaaatct aaatgatgaa 280141 acagggaagg atttagtgcg cacggcattg gatggcggcg tcaattttat cgataccgcc 280201 tttatatatg gattggggcg atctgaagaa ttaatcggcg aagtcgtaca ggaacgcggc 280261 gtgcggaatg agctcatcat cgccaccaaa ggagctcata aagaagtgga cggcagcatt 280321 gaattagaca atagccggga gtttcttcgc agcgaggtgg agaagagcct gaagcggctg 280381 aaaacagatt acattgattt gtattatgtt cactttccgg atggaaaaac acctctcgct 280441 gaagtggcgg gcactttgaa agagctgaag gatgagggga aaatcaaagc gatcggcgct 280501 tcgaacctcg attatcagca attgcaggat tttaatgctg acggctattt ggaggtcttc 280561 caggccgaat attctctcat acagcgtgat gccgagaaag agcttcttcc atactgtgaa 280621 aaacaaggca tctcctttat tccttacttt ccgcttgcgt ccggactgct gacaggaaaa 280681 ttcacgcaag acacagtctt tgatgatttc agaaaggata aacctcaatt tcagggtgaa 280741 acgtttatcc acaatctcaa aaaagtagat aagctgaaag cagtagcgga ggaaaaacaa 280801 gcggatacgg cacatgtcgc cttggcgtgg ctgttaacga gaccggcgat tgatgccatt 280861 attccaggag ctaaacgacc ggagcaatta caggataacc tgaaaacctt gaacattgaa 280921 ctgaccgaag atgaagtgaa tttcatcagc gacattttca aataaaaaag gaaatagccg 280981 tcatggctat ttccttttgg tgttttattc tttgatgaat gcttcgacta attctgctgc 281041 tctgtaatca tccatatcaa gctgccattg gtcgatgtca tttttcttca ttttcacttc 281101 aactgttttt tcagatgaag caggtccaag ctttttgaat tcctcaggat agacttgaag 281161 cgcgtatttc actgcctctt catagctggc actagagttt ttactgtagt agtctttcac 281221 tttgtcttcg atgcggtctg aaagagaaga tgcatctaca ggtttaactg tggcttcaac 281281 aattgcttcg tctttagaga ttgaagtcgt ttttgcttga atggaagagt ttttgcttaa 281341 tccctcttta atgccgttca cgatattatc aagcgctttg ctgtccgcat atgtgctgga 281401 aaggccggaa gctgagagat aaccgtcttt ggctgattca ttaaaatcat ttacaatttc 281461 atttttgtta gcgccggtga ttttttcgaa atcggcgtta tctttgccga aaagaaggac 281521 atcaacataa gctgataacg cttttgcaga atcttggagc ttatctgccg tcgccaggat 281581 ttttttgtct tttccgtcaa ttttaaaagt aactgatttt ggctttttat caccgtaaga 281641 ttccggcgta tagttaagct cgtattgctt gcctttatct acaacgaaga aaagatttcc 281701 ttcaacggat ttgtcagcgt taatcgtgct gccctgaagc ttttcgctat agtcttcagg 281761 gtctgtgtca gacattttgg tatcaccttg atacaatgtg aaatccatac tgtctacatt 281821 cagcgggtct tttcctgtgt ttttcaccgc gacattgact tttaacacaa gctggtcatc 281881 tgaagtggac ttatcatatt tagacggaag tgtgtaagag acatccttga ttttgacttg 281941 agctatatct gagctttttt ctgtttctga ttctttcttc tccgcgcttg ttttgctgcc 282001 ggaacaagca gctgtaaaca tcatcagcag aagaattagg aaaacagcgt acgttttttt 282061 ctgaaacatt catttttcct cctcaaatgg tttaggaaag gggagtcttt tgtctttgag 282121 aaatggatct ttttgaatgg attagcatca tataaccaaa aaaatcagtt cttttctcac 282181 ggttttcacc ggattttctg gaaactccgc cctcctttgt catgaatgga cctataaaaa 282241 gttacaacgg aattaatttt aagattatta gcttttatat tgaataggtt catcatccta 282301 tttttggtga aaaatgttct ggtaaaactg gtaaactcag aaaactgtgt attttagact 282361 attacttttt gattagttgg agggaactta agaaggatga aaggggccgc ctttgtgaag 282421 aaagagggac tgaaacaaaa agcactggaa atcggccggg tgccgacaca cttaaaactg 282481 gaaattgaag attatggcgg tgatgataaa agagctcatt tttgttgggc agatcctcag 282541 gatgagaata ccggcattat cgtggagctt ggaccggacg gagagctgga atccctttcc 282601 cgtgatattg agcctgaaag cggagaaagg ctgtctgagg agaaactaga ggatatcatg 282661 cgccaatttg tcgagactca tcatccgggg gcactctctg cctttgttcg tgaagaaaat 282721 gaccgtgcat acggcgataa agtgagattt tcatatgttc aaatggaggc tgggcttcct 282781 ctccccatga gcggatttat ggctgatgtt tccttatcag gtgagattgt ttacttccgt 282841 tattacggcg aagcgggcag catcatcaag ccaaagcggg tcgcggatgt tgaagaggca 282901 cttgccttta tcaagaagga cgtggagttc gaccttttgt ttgaggttct ccatcgttct 282961 gtttacaaaa acggagatga tcagccgcat ttggtgtacg agcctgaagg tagggcgatt 283021 accgtacctg cggatttggt tcaagaagaa caagcagttg atgatgacga tgattacagg 283081 gagccggaga gctttcctct ccctttattc gagggcatcc gcgaaaaggc cgatcctgac 283141 agcatgattg gtattgaaaa tgggtttgtc aaagagcggg aagcggattt gggagatggg 283201 agaattggaa tcgtttggcg gaatccggat gaccctgtgt atcagccggc ggataaaagc 283261 atggacagct ggtttaaggg acggactcat caagtgctga aaaccatcta taacaaagaa 283321 accggaaaac tcgaaggcgt catgtcattt atggagaaaa aagggccgct gacagtaacc 283381 ttggcagagt gtgaaaaaat cgcgcttcgc tttctatttg ctttatttcc gaatgccgat 283441 caatatttta ggatcagata cgacgaaaaa gatgaagaag aaaacgcagt cgctggtttt 283501 acgtttgaag cgcattgtca cggagttccg ctccgatttg ggcagatcag aatttgtgtc 283561 agccgccaga cagggtatat caccgtttat atgggaccgg atattgaccc aaataagctg 283621 gcaaccattg atcctgtgcc ggctatttca gttgaacaag ccaagtctat cttttggcag 283681 cattttaaag ttgagcttgg ctgggaaaga gagtacgggg atgatgaaga acacagctac 283741 cggctcgtct ataagccggt gtatccgcat tttatcgatg cacatacagg ggagcctgtc 283801 ttcagcatat ggtgaaacag ccaaaagtca cgcaattgcc tcagatatag aagagagtat 283861 gtgatgaaag taacagaaag aatctcaaaa aacaatgaca ataatagaaa aggacctttc 283921 ttcactttaa atgaagaaag gtctttttat ataataaaca ggattctctt tgtcgtagac 283981 tctttgaaag ggatgacttc attggttaat aaacagctga aaaagaaggc gcaggagatc 284041 ggaaatgtac cgacgcatta tgagcttgag atagaagatt acgaccaaaa gcaaaagaag 284101 tacgggcagg catattttat ctggaaggac cctaaagatc cggaaaagca cattacagtt 284161 gaacttagaa atgacggcgc cttgctcacc ttttcaacaa ctgtccactc cgagacagac 284221 aaaaaacttc cagatgccga gctgaagctg acggctcttc agtttgccgc tgccaatcat 284281 cccggcacat ttatgaattt tcattttcaa ggcaaggaag aaagggggca gcacatccgg 284341 tttgtctata ccaaaatgga gctggggctt ccgattccca attcaggctt tttaattgat 284401 atgacacgaa gcggtcagat tgtccacttt ctatattacg gggaagggca taaagccgaa 284461 gttccgacgg aatttgtagc aaaagagaag gttgtatccc attacttaaa cacaatgtct 284521 tttgagctga tgtacgatgt cattgatggc gaacaggaac caaggcttgt atatgaaccg 284581 attctaccgg gatacagcta tcccgcagat gtagacgaaa ttgtgcccga ccagcatatc 284641 gcagatgaaa gaatagaaaa cacggcgcca ctgccgccgc ttcagaacaa ggaagaagtt 284701 gatatatttg ccttgctggg ttttacctct gatatgcaga aagtcagtga aagagacttt 284761 ggagaacaaa ttggaagcac gtggcgcagg ggcgctgcgc cggagcgtaa ggatttaagc 284821 ataggaagct attttgaaac gagaaataaa aatacaatca aaatgaagac ggataaaaga 284881 accggaaaat taaaagcagc gctttctttt atggactggc ggaacaacct ccaatgctcc 284941 acggaagaat gccaagagat agcgcttcaa tttttgtatg ccctctatcc gagagcggct 285001 gagtttttca gggtgaatcc cgtccgaatt gatgaaagag ggagagtccg caaccatttt 285061 tctgtctggt ataaaggagt gccgctgcgg ttcggcgctg cccgcatcat tgtcaatccg 285121 gaaactgggt tgattgacgc ttttatggcg cctgatattg aacctgaaca attggaagcg 285181 ataaatcaca ggccggatgt ttccgctgaa gaagcgaaag aagcattttt agccgctttt 285241 gatgtgaaac tggaatggca gcctgatttt acagcaggca gtgaccagca ctgcaaactt 285301 gtctataagc cggtttaccc ttcctatatt gatgcgcaca taaggaaaaa gaaaaggctg 285361 tgaggggtgt ctagttagga atcatctcca agtgggggta gtccttgaat cgtttccaat 285421 ccccgcccca ttcgaaaccg agtgtcttag cgatctcgac aacctccagc caatctgatt 285481 ttccgttttg attgccgtca tattccatat cccatatgat gctgccatcc tttttttgaa 285541 gggcgaaatc aatcgctaaa ccatagttat gatacgattc ccctcctctt gcataggtga 285601 caatattccc tttttttgta cgtccctgtt tatataattc atcttgttcc ttaaaggacc 285661 tgaatccttc agtaatgacg acgtcaatgc ctttattcgc tgcagcggct ttgagtgcat 285721 cggcattctg cttcacaatc ggatgaagat ccgaggggac aggcatgtcc tgcaaggcgt 285781 tttgagaatg ccattcatgc cgaatataac taaaacaaag atctagaaga aatagaatac 285841 ataagataac aaatgttttt gcgggtaagt tcatatcggt ctcactttct caagatgtgc 285901 tgaatgttaa cgcttttaag tgattgactc tctctaaaag cgaacagcta tgataaaata 285961 taacataaat agtagcagga ggaaggaggc agaccgatga gagcaaagat tccatcagaa 286021 gaagtagcag taaagctgaa tgaatggtac aagctcattc gcgcatttga agcagatcaa 286081 gcagaagcgt taaagcagga gattgaatat gatttagaag atatggaaga gaatcaggac 286141 ttgcttttat atttttcttt gatggaattc cggcatcgaa tcatgcttga taagctgatg 286201 ccggtgaaag acagcgatac caagcctccg ttctctgata tgctgaacga aattgaaagc 286261 aatcagcaaa aactcacggg cttactggaa tactactttt attatttcag aggaatgtac 286321 gaattcaagc agaaaaattt catattagcg attgaccatt ataaacatgc cgaggaaaag 286381 ctcgagtatg tcgaggatga gatcgaaaaa gctgagtttc tttttaaagt cgcagaagtg 286441 tattatcaca tcaaacaaac gtatttttcc atgaattatg cgagccaggc gcttgatatc 286501 tatacgaaat atgaactgta cggtcgccgc cgggttcagt gtgaatttat catcgccgga 286561 aatttgaccg atgtgtatca tcatgaaaaa gcactgaccc acttgtgcag cgctttagaa 286621 catgccaggc agcttgaaga agcgtacatg atcgctgctg cctattataa tgtcggacac 286681 tgtaagtaca gtctgggtga ttacaaagaa gcggagggct atttcaaaac agccgccgcc 286741 atttttgagg agcacaactt tcagcaagct gttcaagctg tattttcact gacccatatc 286801 tactgtaaag agggaaaata cgacaaggca gtagaggctt atgaccgcgg gataaagagc 286861 gcggctgaat gggaggatga catgtacttg acgaaattcc gcctcattca tgagctgtat 286921 cttggaagcg gcgacctgaa cgtgcttaca gaatgctttg acctgctgga atccaggcag 286981 cttcttgctg acgccgaaga tctgctgcat gatacagcgg aacgtttcaa tcagttggaa 287041 cattacgagt ccgccgcttt cttttaccgc aggctgatga atattaaaaa gaagcttgcc 287101 gagcagcgtt ttcaatagga aatggcagag aactacaggt tctctgcttt ttttgtgctg 287161 ttttcaactc ggaaaaacag ggtattttcc actgcatagt gagaaacaga ggaggatatc 287221 aagtatgtac aaagatttaa ccggaaaaac agcgattgtg acagggtctt caaaaggaat 287281 cgggaaagcc attgcggaac ggttcggaaa ggagaaaatg aatgttgttg taaattacca 287341 cagcgacccg tctggagcag atgaaactct ggaaatcatt aagcagaacg gagggaaagc 287401 cgtctcagtt gaggcggacg tgtcaaaaga agaggggatt caggcgctct tggacacagc 287461 tttagagcat ttcggcacgc tcgatgtgat ggtaaacaac tccggtttta acggcgttga 287521 ggcgatgccg catgagatga gtcttgaaga ttggcagaga gtgattgatg tcaatgttac 287581 cggaaccttt ctgggagcga aagcagcact taaccacatg atgaaaaaca atatcaaggg 287641 caatgtgctg aatatctcaa gtgttcatca gcagattccg cgccctgtaa acgttcagta 287701 ttccacatcc aaaggcggca tcaagatgat gacggaaacg ctggcgctca attatgcgga 287761 taagggaatc cgcgtcaatg cgatagcgcc cggcaccatt gccacagaat caaatgttga 287821 tacgaaaaag gaagagagca ggcaaaaaca attgaaaaaa atcccgatga aagccttcgg 287881 aaagcctgaa gaagtggcgg cagcagcagc ttggctcgta tctgaggaag caagctatgt 287941 gaccggcgca acacttttcg tcgacggcgg aatgacactt tatccatctc agcttgaata 288001 gaagacaaaa cagggggatt gcgggatgaa aacagactgg tggaaggatg cagtggtgta 288061 ccaaatttac ccgagaagct ttcaggacag caatggagac ggaattgggg acttgcgggg 288121 gattatttcc cgtcttgact acataaagga gctcggggca gatgtgattt ggatttgccc 288181 gatctatcct tctccgaatg ttgattacgg ctatgatgtg acaaaccata aggcgattat 288241 ggattcttac ggaacaatgg acgattttca cgagctgctg gaccaggtgc atcagcgggg 288301 attaaagctg gtgatggact ttgtgttaaa tcacacctcg gtcgagcatc cgtggtttaa 288361 agaagcggag ctggacaaaa acagcaaata ccgtagctat tattattggc gtcccggcac 288421 aaagaacggc ccgccgacgg actggctctc aaactatgga tgcccggtct ggcaatacga 288481 agagcacacc ggagaatact atctccatat gaatgccgtc aaacaagctg atttaaactg 288541 ggaaaatccc gaagttcgcc aggcggtgta tgacatgatg aaattttggc tcgataaagg 288601 ggtcgacggt ttgcgaattg atcagctcca tctcatttct aagaaagaat atcttccttc 288661 gtatgaggac tatatcaatc agcaggcaga gccgaagccc tttcagccaa atggcgaacg 288721 aatccatgac tatttaaaag aaatcacaga tgaagtgttt tctcattatg atgtcatgtc 288781 tgtcggagag gtcggcagtg tcacaccgga agaaggcctg aaatatacgg gaacagataa 288841 gcatgagctg aatatgattt ttcactttca gcatatggag cttgatcagc agcccggaaa 288901 agaacattgg gatttgaagc cccttgagct ttctgattta aaatcggttt tgacaaaatg 288961 gcaaaagaag cttgaacatc aaggctggaa tacattgttt tggtgcaacc acgaccagcc 289021 ccggattgtg tccagattcg gagacgatgg ggaataccgc aaagcatcag cgaaaatgct 289081 ggcagccgta atttatttta tgaagggcac gccgtatatt tatcagggag aagaaatcgg 289141 gatgacaaac gcgccgttca cccggattga agactacaaa gatatccaaa cgatcaatat 289201 gtatcataaa cgggtgtttg aaaaaggcta tgatccaaat gatgtgatga gatcgatctt 289261 agccaaaagc cgggatcacg cccggacccc gatgcagtgg aacagcggca aaaatgccgg 289321 atttactgac ggcacgcctt ggctgaaggt caatccgaac ttcaccgcaa tcaatgtgga 289381 ggaagcgcag ggagatcctg attctgtctt aaactattac aaaaagctga tcagcctgag 289441 aaagcagtac gctgacctca tgaaagggag ctttgatctt ttgcttccgg acgatccgca 289501 gttgtttgta tacatgagag aaaacagtaa acaacagctt ttgtcggtca ataatttttc 289561 aaaagagcag gctgtttttc agtggcctaa gaactgcggc aaagctcagg cctcactgct 289621 tctcagcaat tataacaacg atgatcttga tgacgaaatg gtgttccggc cttatgagag 289681 cagggtctat cttctggaca aaacaaacta atgattgaag tagcccggca tttttagccg 289741 ggttttttta gtacatatat tcgctctgca ggcgggaaga ataaatgaaa atgaaattta 289801 ttcttgcaaa acgtaatgac ttcggtttat tatgatatag gattacaaaa tcgttatcat 289861 tttgatttaa agttactgaa aaagagggga tatacgatat gtttaaaaaa tggagcggtt 289921 tgtttgtgat tgcagcgtgc tttttattag ttgcagcatg cggcaactca tcaacaaaag 289981 ggtcggcgga ttcaaagggt gataaactgc acgttgtcac aacgttctac ccgatgtatg 290041 aattcacaaa acaaattgta aaagacaaag gcgatgtgga tctgttaatc ccatcttccg 290101 ttgaaccgca tgattgggaa ccgacgccga aagacattgc caacattcag gatgctgatt 290161 tgttcgttta taatagtgaa tacatggaga catgggttcc gtcagctgaa aaaagcatgg 290221 gccaaggcca tgccgttttc gttaatgcaa gcaaaggcat tgatttaatg gaaggctctg 290281 aagaagaaca cgaagagcat gatcatgggg agcatgagca cagtcatgca atggaccctc 290341 acgtatggct tagccctgtt ctggcacaga aggaagttaa aaatattacg gctcaaatcg 290401 tgaagcagga cccggataac aaagaatact atgagaaaaa tagtaaagaa tatattgcaa 290461 aactgcagga tcttgataaa ctatatcgta caaccgcaaa aaaagcggag aaaaaagaat 290521 ttatcacgca gcatacagct tttggctatc tggcaaaaga atacggcttg aagcaggttc 290581 cgattgcagg gctttcacct gaccaagaac cgagcgcagc cagcttggca aagctgaaaa 290641 catatgccaa agaacataat gtaaaagtta tttactttga agaaattgca tcctcaaagg 290701 tcgcagatac gctcgccagt gaaatcggcg cgaagacaga agtgctgaat acactggaag 290761 gcttgagcaa agaagaacag gataaaggtt tagggtatat cgacattatg aaacaaaacc 290821 tcgatgccct gaaagattca ctattggtta aatcataaga tagtgtgcgc cggaggggtg 290881 cacactattt ctttgtgaga aaggaagatt aacatgaatc tcgtctcatt gaaagatatc 290941 gttttcggct attcccatac gcctgtttta gataaagtat cacttgatat tgaaagcggt 291001 gagttcgtcg gcatcactgg accaaacggc gcctctaaat cgacgctcat aaaggtaatg 291061 ctcggcatgc tgaaaccgtg ggaaggcaca gtgacgatca gtaaaaggaa tacagaaggg 291121 aaacgcctga ccatagggta cgtcccgcag caaatttctt catttaatgc cggatttccg 291181 agcacggtgc tggagcttgt tcagtcaggc cgctatacaa aagggaaatg gtttaaacgt 291241 ttaaatgaag aagatcatct tgaagtagaa aaagcattga aaatggtgga aatgtgggac 291301 ctccgccatc gtaaaatcgg tgatttatca ggcggacaga aacagaaaat ctgtatcgcc 291361 agaatgctcg ccagcaaccc ggatctgctg atgctggacg aaccgacgac agctgttgat 291421 tacgacagca gaaaaggatt ttacgaattt atgcatcatc tcgtgaaaaa tcacaaccgc 291481 acagttgtga tggttactca cgaacaaaac gaagtacagc aatttttaga taaagtgatt 291541 cgattagaga gaggagaaaa aggcggatgg aaatgtttga cttggaattc atgcgacgag 291601 cttttctagc aggcggcatg atcgccgtca tggctccgat actaggagtg tatctcgttc 291661 tcagaagaca ggccttaatg gctgacacac tttcacatat ctcattgtca ggtgttgcca 291721 tcggcttttt tctcagcacc aatataaccg cagcaagcat agtcgtcgtg accatcggcg 291781 cgatcggaat tgaatacatg cggcgggcgt atcggactta ttcagaagtg tccattgcca 291841 tcttaatggc agctggtttg tccttcgcga tgtttttaat cagcctttcc aaaggcacag 291901 ccaatatgag catcgatcaa tacctatttg gatcgcttgt gacagtaaac cagcagcagg 291961 tctatattat cagtattatc acactgctga tcctgcttta ttttattgta ctgagaaggc 292021 cgctctacct gctgacgttt gatgaagcta cagccaaaac atcgggaatc aatacaaacg 292081 ttctctcgtt gtcattcagt attgtcacag gccttgcgat ttcagtcatt attccgatca 292141 tcggggtcct tcttgtatcg gccctgctcg tattgccggc agccttcgcc atcagaattg 292201 caaaaggctt taacatggtt ttcattacag ccatactcat ttcattattc agcgtattta 292261 cgggactgac atcatcctat cagctcggga cgccgccagg tccgtctatt accctgctat 292321 tgatcgtttt gctattaatc ggatttgcag ttcagggagt ttggacgttt atcaaaaaag 292381 aagctcagcg caaaaaaaga agccgataac atgaaaagca gttttcccta gggaaaactg 292441 ctttttttat agaaacaatt cggcaaggcg ctcataagat tcttttttcg cctcaaaatc 292501 aaacacattg cacagaacca tgatttcatt tgtttcgtag cagcctgtga ggtctaacag 292561 ctgttgtttg acagtggtgg gagaaccgat caccatccgc tttctgtttt cttctatgag 292621 ttttttatcg gacgctgtat agggatgagc tttcgcttcc tcgatgcttg gcacgcggct 292681 gtccaagcct tttccgacgc gaagaagcca cagatcctgg cttaatgcga gttcttctgc 292741 ctcttcatct gtttttgcgc aaatgacaaa aatcgtaaac agtgcggatg gattcgaaaa 292801 atgggctgag ggccgaaagc tttcccggta gatgcggaat gcattttctc ctcgctcggg 292861 attaatgaaa tgcccaaata catatccaat cccctggtgc gccgcgcgtc ttgcgctgtt 292921 ttcaccaaga ccgagcaccc atagctcggg tgccgtacca ataaggggcg ccgctttgat 292981 tccggcatac ggatggtcgg gaggaaggga atctgttaga aaataagaga catcctgcag 293041 ctgtctgtta aattcggtta agcttttttt caccccgtcc gttaatgcaa gtctggtttt 293101 tgtcgtgccg ccgggggagc gaccgacgcc gaggtcaatc cggtttggat acagggcctc 293161 aagctggcga aaggtttcag ccactttaaa tgggctgtat tggggcagaa gcacgccgcc 293221 tgatccgaca cgaatggtgt ttgtctgtgc tgcgatgcgg gcgatcatga tttcaggcgc 293281 tgtgcttgcc agtcctttcg tgctgtgatg ctcggcaaac caataacgct tatagcccca 293341 ctgttcgctt aattgggcaa gctcaaccga atgctggaga gttgtcacag ggctttctcc 293401 tttagaaaca ggtgcctgat caagtatgct taaatgaatc aaaaggccgc ttcctttctg 293461 tctgttttta gatggtgaca ccagaatagg caaaatgact tgcccgcgtc aaatggtttg 293521 tttaagaagc gcactttata gcatttgcaa atcatatatc aaatatggaa gttttttttc 293581 gaggtttttc gtcaattatt cttaactttt acgaaacttt gatataataa caaacgtata 293641 tattagtaat ttacggctta ttttccttgt gagcgtaaaa ataaatgtga ctatcttcac 293701 attttgatga gtaggagtga atcgtgtggc aatttcttta gaaaaaggtc aacgaattga 293761 tttaacaaaa ggaaaagccg gtctgtcaaa attgatggtc ggtctcggct gggacccagt 293821 gtcctcaggc ggaggattct tcagcaaact gcttggcgga ggcggtccga atatcgactg 293881 tgacgcttca gtgctgatgc tggaaaacgg aaaattcacc gataagaaaa acctgattta 293941 tttcggcaac ctgaaaagcc gctgcggcgg tgtacagcat acaggcgaca acctgacggg 294001 tgacggtgcg ggcgatgacg agcaaattat gatagattta gataaagtgc ctggaaacat 294061 cgataagctt gtatttgtag tgaacattta cgattgtgtc agaagaaaac aagatttcgg 294121 catgattcaa aatgcgttta tccgcgtagt tgatcaatct aatcacgagg aaatgctcaa 294181 gtacaatttg agagacaatt acgccggcag aacaagcctg attacagcag aaatctaccg 294241 cagcggcagt gagtggaagt ttgcggcggt cggtgaaggc acaaacgata cgagattaga 294301 agatattatc agtcgatacg tataaaagaa aaggagtgga tgaaacatga caatttcatt 294361 ggcaaaagga caaaaagtag atttaacaaa aacaaatccg ggtctttcaa aggttgttgt 294421 cggtttaggc tgggatacga acaagtatga cggcgggcac gactttgatc ttgactcaag 294481 tgtgtttctg ttagacgccg cgggcaaatg cgcgtcacca aacgacttta ttttctacaa 294541 ccagcttgaa ggcggcaacg gttcagtcgt tcattcaggc gacaacctga ctggtgctgg 294601 cgaaggcgac gatgagaatg taaaagtaaa tctcagcgct gtaccggcaa acattgataa 294661 aatctcattt gttattacca ttcacgatgc agaagcgcgc agccaaaact ttggacaagt 294721 atcaaacgcg tttgtccgca tcgtaaatga agaaacaaat gaagagctca tccgttacga 294781 tcttgcagaa gatttctcta ttgaaacggc aatcattgca ggggagcttt acagacataa 294841 cggcgagtgg aaattctcag caatcggctc aggctaccaa ggcggccttg cccgcattgc 294901 aacagactac ggtttgcaag tcggttaaga caaatacgaa gagcagaaag gagagaggca 294961 gtatggccat tcaattatca aaaggacagc gcattgattt aacaaaaaca aatccgggac 295021 tgactaaagc ggtgatcggc ttaggctggg atacaaacaa gtactccggc ggacacgatt 295081 ttgacctgga tgcttcggcc tttttagttg atgcgcatga taactgcgta aatgatctcg 295141 atttcgtctt ctataataac cttgaacatc cgagcggcgg tgtcatccat acgggtgaca 295201 accgcacggg tgagggcgac ggagatgatg agcagattat cgttgatttc tcaaaaatcc 295261 ctgctcacat tgagaaaatc ggcatcacag tgaccattca cgacgctgaa gcacgcagcc 295321 aaaactttgg acaagtttcc aatgcatttg tccgcgttgt ggatgaagaa acgcagaatg 295381 agcttcttcg cttcgatttg ggagaagact tctccattga aacagctgtt gtcgtttgtg 295441 agctttacag acacggcggc gagtggaaat tcaatgcaat cggcagcgga ttttccggcg 295501 ggctggctgc attgtgccgg aattacggtt tgcaagtgta agcgagtgac aaatagagaa 295561 gtcaccgttt caaattatag gaggaaaaaa cttggacttt ttacatcata ttttgtctac 295621 gtatgcttca tttttcgatt ggaaaatgtg gggggaagtt ctgactgatc ctgtttcctg 295681 gggtttgatc ggttcccttg ttgttctgga aggcctttta tcggccgata acgcgcttgt 295741 tcttgcggtc atggttaaac acctgccgga aaaacagcgg aaaaaagcgt taacgtatgg 295801 tttgtttgga gcttatattt tcaggtttat tttcatcggg ctcggtatgc ttctcattaa 295861 attctggtgg atcaaggtgc ttggcgcgct ttacctggct tggctcgtca ttaagcactt 295921 ctggataggc gaaaaagaag aggaagcgga cggcatgaag aaaaactctt ggatggtccg 295981 cacgttcggg atcttctggg cgactgtcat ttcagtagaa ttaatggatc ttgccttctc 296041 tgtggacagc atcctggccg cgtttgcagt atctgaaaaa gtatgggtgc ttctgattgg 296101 cggtatgctt ggtattttaa tgatgcgtac agtggcaaaa gtgttccttg tgctgattga 296161 taaaattcct gagctggaaa acacagcatt cgtcttaatc ggcattatcg cgctgaaaat 296221 ggcggggagc gctttccatt acgaaatgcc gcactctgta ttcttcatta tcattatcgc 296281 tgcatttgcg gtaacattga tcattcacta catcaataaa caaaagcagg tgcgcgaaca 296341 aacagccgct tcaaaagaag aataaaacaa aacaaggagg gaggttcaat gtccttcctt 296401 ttttgttacc gaaatatcgt ttcaatgaca aaccggaaag gaggatatga tgagacaaga 296461 agaactaacc attcataaag cacttccggc tgatggcgat tggaaaagcc tgctgtttca 296521 gccattgccg gagcgggatc actatgaaac tgcacaaggc ctttcttttt ctcgtcttgc 296581 cggtcagata ttgggcacgc ctattgatga gacggactac tataacgagc tgtatgagct 296641 gtctgtaaac gaccgcataa cgattttgag tgaaacgctt gataaaacaa tcgaaccgga 296701 aacatttcaa aagcttcagc atattcattc catcaatcag aaagaaaaag ggctgtcagt 296761 cagccgcttt gttgcctttc tggacgggga aaagctgatt gcgaagcact caaatccctt 296821 gatgcaccgc catttaagaa aagcgttgat gacgctttta catacctttg cggacagtca 296881 tgaaaagggg ctgaatcatc ctgattttcg cagagtgctg cttgatgtct cgaagttttc 296941 cttaaaccat ctgaaccctt ggctggaaaa aaccgatata gagcgggaga tgccgaaggt 297001 tgtttggtat ggagatgcga cgaaaagcca gctctatttc ttatattatc tgatgctggt 297061 cggctgtgat gtactgctgt tccatccggc gggaacggat cagctggcgc ttgtcgaccc 297121 gaagcaggag ctcggtttta cggaaaagct cccggatgtt tcggagcttc agccgtttcc 297181 gaaagaaaaa ccagaccgga aatcaacagt ggcttaccgc tcaacaaagg aaattgaaca 297241 tgtgctgaat cacgaggaat ccatgctata taagccgtgg cagttcagag atcacacacc 297301 ggtgtccgtt acgctgaaaa cgacctatga tgaattgttt ttaatcacga aagaacgcgc 297361 ctttattcgg ccgaatttca aagctgataa acattccatt gagattccga atgtattcgc 297421 caaaattatg ggcgtgtcga aagacaataa ggaatattgg aacaggcttc atactctagc 297481 ggattatcag gaaacagaaa tggtcagaag ctttccattt acagaagaaa taaagtcgaa 297541 ctatcaattt cactacagcc acgcacttga tcaagaaggg aacattgatc cggacaagct 297601 gatggcaagc aatgtgtggc agtacaaaca gctgccggcg ggcgttcaga ctgccattgc 297661 caaaacgatt tcgagaatgt gcaggtaccc gcggcttaaa gccttgcatc aggaacaagt 297721 caaggatgtt caaatctatt tgtttaaaca aacaacaaac ctgcctgcta atctgctgaa 297781 attgattcaa atgttcgact atgcgcaaac cgttccgaaa ctcgttttat atcatacgga 297841 aatgagcggc ggactcacgc gttcggatgc tgccgccctg ctgttcctga atgaaatcgg 297901 aatcgatatc atcatttata atccgcccgg acaccaagat attgagcagt ttattgaaga 297961 ggatcagtat gatatccact ggctggatga catggtgttt cagcaggact acaaagagcc 298021 ttcgcttgtg aaaaggctct tcagaaccat tacccaaaaa taaggagaga agaaaagcat 298081 gacaacagaa aatcaaaatc cgcttgttct cgataaaaat gaagagattt cccagcaaaa 298141 agctgacgat atccgtcttc agctccgtca ggaaccagaa gtgaagcggc ttgctcaaca 298201 aattgacgtc aaaaaccaaa tggagctgct tgagtacggc aaggagccgg ccgttgaaat 298261 atccaagttc tctgaccgca tcttggggat gatgaaaaca acaagcgtga cagactccgg 298321 cacaatgctg actcagcttg ggaaaatcat ggaccgcttc gacaaaaatg attttgatga 298381 gccaaaggga ttaatggcga aaattttcaa acgcggcggc agcatgattg aaaaaatctt 298441 taaaaagtat cagacgcttg gcggagagat tgaaaaaatc cacgttgaga tttcaaaata 298501 caaagatgag atgacgaaga cgaactacac gctcgatgaa atgtatgaaa acaatatcaa 298561 atactatatg gagcttgaaa aatacgtcgt tgccgggcag atgaaactgg aagagatgca 298621 gtcgatcctt ccttcatatg aggaaaaagc ggcaagcggg aaccagctgg cgcaaatgca 298681 gctcgatacg ttgcgcaacg gcattcaggc gcttgaggaa cgggtgtatg atcttgacat 298741 ggcacggatg gtggcgcttc aaaccgcacc tcaaatccgt ctcctgcagc gaggaaatgc 298801 aaagctgatc gggaaaatca actccgcgtt tatcattacc attccgattt tcaaaaacgg 298861 cattattcag gctgttacgg taaagcggca aaagcttgtg gctgattcca tgagcgagct 298921 tgaccgccgg acaaacgaga tgctgaaacg aaatgctgaa aacatctcga gccaaagtgt 298981 tgaaattgcg agaatggccg gcagaccgag catagatatt gaaacgattg aatcgtcttg 299041 gaacacgatt gtcagcggca tgcaggaaac aaaacaaatc gaagaagaaa acaagcgcct 299101 ccgcgaagac ggcgcgagac gaattgccca gcttcaggat aatattaaaa aagcagcatt 299161 gcagcaataa taaaaacccc gcttgtggaa cataagcggg gtatttcaat tacatcattt 299221 agttaatgac aatgtgtaaa gacaggtgta aacttaaacg gtaatcattt tgcatatcag 299281 aggtgttggc aatgggaaaa caacagccta tatcccagcg taaactgctg ggcgtcgccg 299341 gtttggggtg gctgtttgat gcaatggatg tcggaatatt atcgtttatt atcgccgcgc 299401 tccatgtaga gtggaatctg tcgcccgaag aaatgaaatg gatcggaagc gtcaattcca 299461 tcggcatggc tgcgggtgcg tttttgtttg gtttgcttgc tgatcgaatc ggccgcaaaa 299521 aagtgttcat catcaccctt ttatgctttt ccatcggaag cggcatttcc gcttttgtga 299581 cgagcttatc ggcatttcta atccttcgtt tcgtgattgg tatgggactt ggcggcgagc 299641 ttccagtcgc ttcaacactc gtttcggaag cggttgtgcc tgaaaagcgg ggcagagtga 299701 ttgtgctttt ggaaagcttt tgggccgtgg gctggctcgc agcggccttg atttcttact 299761 ttgtgatacc aagcttcggc tggcaggctg cccttctgtt aactgcgctg actgcttttt 299821 atgcgctgta cctgcggacg agtctacctg attcgccgaa atatgaatcg ctttctgcca 299881 aaaagaggtc gatgtgggag aatgtaaaaa gcgtctgggc aagacagtat atacggccga 299941 cggtgatgct gtcgatcgtt tggttctgtg tggtgttttc ttattacggc atgttcctat 300001 ggctcccgag tgtcatgctg ctgaaaggct tcagcatgat tcaaagcttt gaatatgtcc 300061 tgctgatgac gcttgctcag ctacctggct atttctctgc cgcatggctg attgaaaaag 300121 cgggccggaa gtggatactc gtcgtttact tgattggcac agcaggaagc gcctatttct 300181 tcggaacggc ggattcctta agtcttctgc ttacggctgg agtgctgtta tcgtttttca 300241 atctcggtgc gtggggcgtg ctgtatgctt ataccccgga gcaatacccg actgcgattc 300301 gagcaacagg ttcaggaacg acagcagcgt ttggaagaat cggcggcatc ttcgggcctt 300361 tgctcgtcgg aaccctggca gcccgtcata tttcgttttc ggtcatcttt tcaatctttt 300421 gcattgcaat cttacttgcg gttgcttgta ttttgattat ggggaaagaa acgaaacaaa 300481 ctgagctaga ataggaaaag cacctcttaa aagaggtgct ttcagcgtgt cgacaaaccc 300541 tcgcattcgt tgtcaggact gcgcttcggt gctcaatgcg aagtggatca acggctaaat 300601 tctcaggcgt cctgcctaaa cgccgtcgtc atcacatcct gtgaatgtcc gctcctatgc 300661 tcgtccttcc tagacttcaa gggttttcaa tcacgctgaa aagattttgt caacaatctg 300721 aggcacctct tgaatgaggt gcttttttac aattgcgccc gggctgtgga ttggcgtttc 300781 ccggttttac tgattgtctg gtagagcgtc atagaaagta tgaacagaat ggcagtaaat 300841 cctgtgacag ctccgaaatg ctgtgtgctt tgatataaaa aacctgcaat acttgtaccg 300901 acagtggttc cggcatacat agcggcattg gaaagggaag cgatggttcc tcgcgcattt 300961 ggtgcaatgg attgaaagac acccatcatt aacggaaaga tgatgccagc tgtaaagaac 301021 gtgagaaaaa agccggcttc tactaaaaac aagtttggaa agaacggaag agcgaaatag 301081 agagcgccca ttagcagcat cccgctgatc agtgttttaa acatgcccag cttttctgaa 301141 acccggctgc cgataaggct cccgagcata tttcccagtc cgagtacaag catagctgcg 301201 ccaatttgtg acacggttaa atgataatcc gcggaaagcc aagtacccag aaagctgaac 301261 gatgcgaagt ttccggtttg aaacagaaaa taggcaagca gaatgaccga tgttttcggc 301321 aatgaaaaaa gctcccgata ggggttgaca attgatgggc gcgccaatgg ttcagaaggc 301381 cggatgccag gcatgaccgc cgccaggatc aatagaagaa taagcgagca cgctgacaaa 301441 acgaaaaatg gcgtatgcca tgtaaaggaa gcgagaaacc ctccaatagg aagtccgagc 301501 atttgtgaag cggccaaacc tgctgtcgca atccccatgc cttttatgat ctgagaaggc 301561 tggacaatga ctgggatgga cgcccaaatt tgaggcgtca caaacgcagc gctaacgcct 301621 gcggcaaaac ggaacaggca catggcggca aaagagggag cgatgccgca taaaaatgtg 301681 gatacgataa agcctgcaag tccccacagc atgactgttt tcctgttcag ccggtctgag 301741 attgggcctg caatgaaagc gaagagtgca taaccgagtg cataagcact gaccatccag 301801 cctgacaaat cagtagagac atgaaactga tcctgtaaaa gggggagaag cggcgaaagc 301861 aaaaaggtat ccgtgccaat gacaaacatg acactgaaga aaagccaaat gcgattcaaa 301921 ttttatcact cctattgttt tataacttta aaactatgaa acagatatgt atagagaaaa 301981 ccctttgtta gagggtttcc aaaaagccag gcaggtatgt ttgaaatgtg tcttcacgca 302041 gactgacgta ttttgtccgc gaatctttcc gggttgccgt caatcccgct tcacgcagcg 302101 ttttaaaatg ataagatgcc gtggttttga caatattgca cttttcacct acttcaccgc 302161 agctgagttc ttttccgctg acataaagcg tacgaataat ggcaagcctt gattcatcag 302221 acagtgcttt aaaaatttgc gctctgattt gatcatctga ttgtttcata gtcatgaaac 302281 tataatacat aatgggtgtt gaaaaagcaa cttatttttc cagtaaagga gcaggaagtc 302341 ataagaggaa ggaggaattc aattccaata aaagcgtttt caactaaagg taggagaaaa 302401 atcacccgta aaatacaatc atataggagg attacagagc atttagaagc ataaataaga 302461 tcatgtggtc acatggatgt ttataaagaa atggtacaga ataaaagaga atatgctgtt 302521 tgtgtgggaa gttacataaa tgttacggta ataaagattg cttaatatgg agggaaaata 302581 tgagtgtaga tgagaaacca attaagataa aagtcgagaa agtctctaag atttttggga 302641 aacaaacaaa gaaggcagtt caaatgcttg ccaacggaaa gacaaaaaaa gagatcctga 302701 aagcaaccgg atcaaccgtt ggggttaatc aggcagattt tgaagtatat gatggtgaga 302761 tatttgtcat catgggtcta tcagggagcg gtaaatcaac tttagtacgg atgttaaacc 302821 ggcttattga accgactgcc ggaaatattt acattgatgg tgacatgata acaaatatgt 302881 caaaagacca gctccgggaa gtccgccgga aaaaaatcag catggtcttc caaaagttcg 302941 ctctgtttcc gcacagaacg atacttgaaa acacagaata cggactggag cttcaaggtg 303001 tagacaaaca agagcggcag caaaaagcgc ttgagtctct taagctcgtt ggactggaag 303061 gatttgaaca ccaatatccc gaccagcttt ccggcgggat gcagcagcgt gtcggccttg 303121 cccgcgcgtt gacgaatgac ccggacatcc ttctgatgga cgaagcgttc agtgcgctcg 303181 atccactgat tcgtaaagat atgcaggatg agcttcttga tcttcacgat aatgtcggaa 303241 aaacaattat ctttattacg catgacttgg acgaagcgtt gcggatcggc gacagaattg 303301 tcctaatgaa ggacggcaac atcgttcaaa tcggcacgcc tgaagaaatc ctgatgaatc 303361 catctaacga atatgttgag aaattcgtcg aagatgttga tttgtctaaa gtcctcacag 303421 caggccacat tatgaaacgc gctgaaacag tgcggattga taaagggcct cgcgtagcat 303481 tgacactgat gaaaaacctt ggaatttctt caatttatgc agtggataaa caaaagaaat 303541 tattaggtgt tatctatgcg tctgatgcga aaaaagcggc tgagtctgat ttgtcacttc 303601 aagacatctt gaatacagaa tttacgactg taccagagaa tacgtatctg actgagattt 303661 ttgacgttgt gtccgatgcg aatattccaa ttgcggttgt ggatgagaag caaagaatga 303721 aaggaattgt cgtaagaggc gcgctgattg gcgcacttgc cggcaataac gagtatatca 303781 atgctgaagg cactaacgaa caaacacaag atccttctgc acaggaggtg aaataagatg 303841 gatagactgc ctagaatacc tttagcagat attattgacc gttttgttga ctggattacg 303901 atgacgtttg gcggattctt cgacggaatc gctaacggat tggccgcttt tgtaaatgga 303961 attgtcaccg gtcttggatt tattccatct attttgttaa cgattatttt cgccgcactt 304021 gcgtggtgga tcagtacaag gggaattgcg ttatttacgt tgattggatt cctcctgatc 304081 gattatttag gatattggga cccaatgctg caaacattgg cgcttgtttt gacatctgtg 304141 attatttcga ttgtggtcgg ggttccgatc ggaatttggg cgtctcagaa agaaacggtt 304201 cgccgtattg taacgccaat tcttgattta atgcagacaa tgcctgcttt cgtatatcta 304261 ttgccggcga ttttcttctt taacatcggt gttgtgccgg gtgttgttgc atctgttatc 304321 ttcgcgatgc cgccgacaat ccgcatgact gttctcggta ttaaacaagt gccggcggat 304381 ttgattgaag cgactgaggc attcggttct acaacagctc agcgtttgtt taaagttcag 304441 ctcccgcttg cgacaaaaac gattttggcc gggatcaacc agagcatcat gcttgcgtta 304501 tcaatggttg ttatcgccgc aatggtcggt gcaccgggac ttggttctga agtatacagt 304561 gccgttacac agctgaaaac cggggtcgga gtagaggccg gtatcgccat cgttatcgtt 304621 gccattaccc tggaccgtat tactcaaaat attaaagtga agaagaaaag cagggggaat 304681 gcctgatgct taaaaaaatc ataggcatcg gcgtttccgc catgctggcg ctctcacttg 304741 cggcttgcgg ttcagaaaac gatgaaaatg catccgcagc agaacaagtg aataagacca 304801 tcatcgggat tgaccccggt tcagggatta tgtccctgac tgacaaagcg atgaaggatt 304861 atgacctgaa tgactggaca ttgatttcag cgtcaagtgc tgcgatgacc gctacgctta 304921 aaaagtcata cgaccgtaag aaaccgatta tcattacagg atggacaccg cactggatgt 304981 tctccagata taagctgaaa tatctcgatg atccgaaaca atcttatggc agcgcagagg 305041 aaatccatac gatcacacgc aaaggcttca gcaaagagca gccgaatgcc gcaaagcttc 305101 tgagccagtt taaatggacg caggacgaaa tgggcgaaat catgatcaag gtggaagaag 305161 gcgagaaacc tgccaaagtt gctgctgagt acgtcaataa acacaaggat cagattgccg 305221 aatggacaaa aggcgttcaa aaggtgaagg gagacaaaat caaccttgcc tatgtggcgt 305281 gggacagtga gattgcaagt acaaacgtca taggcaaagt cttagaagac ttgggctatg 305341 aggtaacact tactcaggta gaggctgggc cgatgtggac tgcaattgcg acgggaagtg 305401 cggatgcatc cctttccgca tggctgccga atacccataa agcatacgcc gctaaatata 305461 aaggcaaata tgatgatatt ggcaccagta tgactggtgt gaagatgggg cttgttgttc 305521 ctcaatatat gaaaaatgtc aactcaattg aagatttgaa gaagtaatca aaaaagcagc 305581 ctgtgtcagg ctgctttttt tgcgttaaga agcgttagcg gcagcaagtg attccgcctt 305641 ctgaaatgtt ttgagcacgg cgttcgccaa aatatgaatg ccggtaaaca tcgcatttct 305701 gtcaaaggtc atgtgcggat gatggagccc cggctggagc ccgcagccta gtccgagcat 305761 cgttgttttc agattcggca ccttcacggc gtaaaaatgg aaatcctcgc cgccggtggt 305821 gacaagcggg tcatcaagcc gctcagcccc gatgatttcc gtaatggctt ctgccatgat 305881 cgcttcagct tctttatttt gtgttgccgc aggaaggctg tgttctttgt gcagctcgat 305941 ctttgcgcca aatgcagcgg cggccgcttc acaggctctt tctgtttcgg cgattaatgc 306001 ctccatggct tcattggtct gtgcgcgcaa atcaaggctg aacgatgctt ttcctggaat 306061 gatgttagag ctttcaccgc cggcttgcag ttttgtcatt ttgacggtat gcgggatttg 306121 cgggtcaata tgaatgagtc cgagcttgtg tacaagaaat gccgcaattt caatgctgtt 306181 tttcccgagg tgcggacggg cgccatgagc ctcttccccg atgatcgttc cctcaatgtg 306241 ctggcttgat ccgtgcagaa tagaaggagc gcagcggccg ttctgtgttt cctggatcgg 306301 acggacgtga acgccataca aatagtcgat atcatcaagc acgccttctt ctatcatttt 306361 caaggcgccg ccgccttttt cttctgccgg ctgaaagata aaacggattg tgcccttcgg 306421 aagctcaggt tgttttttta gcagcattaa cgtgcccaat gccattgtca tatgtgaatc 306481 gtgtccgcag gaatggttgg cgcgaaatgt gccgttaacc tcctgccaca gcgcgtcaat 306541 atcagcgcgt accgctacaa caggtgagcc tgagccgatt tcgccgacaa ccccggtgca 306601 gtctgaaaac gtgcgcgtcc ggcaccctaa atcctcaagc ttttgtttca aaaatgaagt 306661 tgtctcatat tccttccagc tgacttcagg gttcgcgtgc agatgctcga agatgtccat 306721 aatggtttgt ttcatttctt ctgaaagctt ttgcatggta agaaatacct ccttctatca 306781 gaatgaattt ttaccttctt tactttattt atattgaaac aggaagatag gctgtatata 306841 atatagcaca tattgctact attcagaata attaatattt tcaaacagag gggatggatc 306901 gaaatatgag tatgccagca gccgaaacac agcctaagaa aaaacgtatg acatttaaaa 306961 tgcctgacgc ctatgtcctc ttatttatga ttgctttcat ttgcgcaatc gcttcatata 307021 ttgtgccggc aggtgaattt gaccgcgtga caaaggggga tgtcacgacc gctgttccgg 307081 gaagctatca ttcaattgaa cagtctccgg tcagattgat cagctttttt acttctctac 307141 aggatggaat ggttggatca gcacccatca tctttctgat tttattcaca ggcggcacca 307201 ttgctattct agaaaaaacg ggtgccatca atggcctgat ttacaatgtc atcagcaaat 307261 tccgcacaaa gcaattatta tttatttgta ttgtcggcgc attgttctcc attctcggaa 307321 caaccgggat tgtcgtgaat tcagttatcg gttttatccc catcggcctc attgtggcac 307381 gatccttaaa atgggacgca gtcgcgggag ccgctgttat atacatcggc tgctacgctg 307441 gatttaactc caccatatta tcaccgtcac cgctcggttt atcacaatca atcgcggagc 307501 tccctctttt ctcaggaatc ggcctgcgag ttgtgatata catatgcttt ttgctgtctt 307561 ctattattta tatctatttg tatacgagaa aattaaaaaa atcaaaagat gccagtgtgt 307621 taggaacaga ttggttccct gcggcaggaa tgggcgaagc cggtaaagaa gaagatcagt 307681 cagtgccgtt taccgttcgc cataagctga ttttggctgt ggcgggactc tcacttgtcg 307741 gatttttata cggcgctttg aagcttggct ggtcagattc ccaaatggct gcgacattta 307801 tttttatttc tgtccttgcc ggtttaatag gcgggcttgc ggcgaacgat attgccaaaa 307861 ccttcattac gggctgccaa agtcttgtat acggggcgct gattgtcggg atggcacgaa 307921 gcatttccgt tatccttgaa aatggaaagc ttctcgatac tgtcgtcaat gctttggctt 307981 cacttttgga tggattcagc ccgattgctg gggcaatcgg catgtatatc gccagtgcgc 308041 tgcttcattt tctcatctct tcaggttctg gcgaagccgt tgtatttatt ccaatcctgg 308101 cgccgctcgc tgatttgatg ggaatcacga gacaggttgc ggttgaagcg gttatgcttg 308161 gagaaggggt cgtcaactgt gtgaacccga catccggcgt tctcatggcg gtgcttgccg 308221 ccagcggtat tccgtatgtc aagtggctgc ggtttatggt gccgcttgct ctgatttggt 308281 tcttgatcgg gcttgtcttt atcgtgatcg gagtcatgat caattggggg ccgttttaac 308341 gattgctgcc cgccggcttg tacggcgggc ttttgagtta ttcattgcag aagcgcaggc 308401 tgttattgta acatgtaagc cataagccat tcgtaaaagt gcgggaggaa ggtcatgaat 308461 aatctgcgta atagactttc aggcgtgaat gggaaaaata agagagtaaa agaaaaagaa 308521 caaaaaatct ggtcggagat tgggatgata gcgggagcat ttgcgctgct tgatgtgatc 308581 atccgcggca ttatgtttga atttccgttt aaagaatggg ctgcaagcct tgtgtttttg 308641 ttcatcatta tcttatatta ctgcatcagg gctgcggcat ccggaatgct catgccgaga 308701 atagacacca aagaagaact gcaaaaacgg gtgaagcagc agcgaataga atcaattgcg 308761 gtcgcctttg cggtagtggt gcttacgatg tacgacaggg ggattcccca tacattcttc 308821 gcttggctga aaatgattct tctttttatc gtctgcggcg gcgttctgtt tctgcttcgg 308881 tatgtgattg tgaagctggc ttacagaaga gcggtaaaag aagaaataaa aaagaaatca 308941 tcttttttgt ttggaaagcg agggaagcgt tcacagtttc gggcagcttt ttttatagga 309001 acattgattt gtattcactc tgccaagttg ttttgataga gtgattgtga taattttaaa 309061 tgtaagcgtt aacaaaattc tccagtcttc acatcggttt gaaaggagga agcggaagaa 309121 tgaagtaaga gggatttttg actccgaagt aagtcttcaa aaaatcaaat aaggagtgtc 309181 aagaatgttt gcaaaacgat tcaaaacctc tttactgccg ttattcgctg gatttttatt 309241 gctgtttcat ttggttctgg caggaccggc ggctgcgagt gctgaaacgg cgaacaaatc 309301 gaatgagctt acagcaccgt cgatcaaaag cggaaccatt cttcatgcat ggaattggtc 309361 gttcaatacg ttaaaacaca atatgaagga tattcatgat gcaggatata cagccattca 309421 gacatctccg attaaccaag taaaggaagg gaatcaagga gataaaagca tgtcgaactg 309481 gtactggctg tatcagccga catcgtatca aattggcaac cgttacttag gtactgaaca 309541 agaatttaaa gaaatgtgtg cagccgctga agaatatggc ataaaggtca ttgttgacgc 309601 ggtcatcaat cataccacca gtgattatgc cgcgatttcc aatgaggtta agagtattcc 309661 aaactggaca catggaaaca cacaaattaa aaactggtct gatcgatggg atgtcacgca 309721 gaattcattg ctcgggctgt atgactggaa tacacaaaat acacaagtac agtcctatct 309781 gaaacggttc ttagacaggg cattgaatga cggggcagac ggttttcgat ttgatgccgc 309841 caaacatata gagcttccag atgatggcag ttacggcagt caattttggc cgaatatcac 309901 aaatacatct gcagagttcc aatacggaga aatcctgcag gatagtgcct ccagagatgc 309961 tgcatatgcg aattatatgg atgtgacagc gtctaactat gggcattcca taaggtccgc 310021 tttaaagaat cgtaatctgg gcgtgtcgaa tatctcccac tatgcatctg atgtgtctgc 310081 ggacaagcta gtgacatggg tagagtcgca tgatacgtat gccaatgatg atgaagagtc 310141 gacatggatg agcgatgatg atatccgttt aggctgggcg gtgatagctt ctcgttcagg 310201 cagtacgcct cttttctttt ccagacctga gggaggcgga aatggtgtga ggttcccggg 310261 gaaaagccaa ataggcgatc gcgggagtgc tttatttgaa gatcaggcta tcactgcggt 310321 caatagattt cacaatgtga tggctggaca gcctgaggaa ctctcgaacc cgaatggaaa 310381 caaccagata tttatgaatc agcgcggctc acatggcgtt gtgctggcaa atgcaggttc 310441 atcctctgtc tctatcaata cggcaacaaa attgcctgat ggcaggtatg acaataaagc 310501 tggagcgggt tcatttcaag tgaacgatgg taaactgaca ggcacgatca atgccaggtc 310561 tgtagctgtg ctttatcctg atgatattgc aaaagcgcct catgttttcc ttgagaatta 310621 caaaacaggt gtaacacatt ctttcaatga tcaactgacg attaccttgc gtgcagatgc 310681 gaatacaaca aaagccgttt atcaaatcaa taatggacca gagacggcgt ttaaggatgg 310741 agatcaattc acaatcggaa aaggagatcc atttggcaaa acatacacca tcatgttaaa 310801 aggaacgaac agtgatggtg taacgaggac cgagaaatac agttttgtta aaagagatcc 310861 agcgtcggcc aaaaccatcg gctatcaaaa tccgaatcat tggagccagg taaatgctta 310921 tatctataaa catgatggga gccgagtaat tgaattgacc ggatcttggc ctggaaaacc 310981 aatgactaaa aatgcagacg gaatttacac gctgacgctg cctgcggaca cggatacaac 311041 caacgcaaaa gtgattttta ataatggcag cgcccaagtg cccggtcaga atcagcctgg 311101 ctttgattac gtgctaaatg gtttatataa tgactcgggc ttaagcggtt ctcttcccca 311161 ttgagggcaa ggctagacgg gacttaccga aagaaaccat caatgatggt ttcttttttg 311221 ttcataaatc agacaaaact tttctcttgc aaaagtttgt gaagtgttgc acaatataaa 311281 tgtgaaatac ttcacaaaca aaaagacatc aaagagaaac ataccctgga aggatgatta 311341 atgatgaaca aacatgtaaa taaagtagct ttaatcggag cgggttttgt tggaagcagt 311401 tatgcatttg cgttaattaa ccaaggaatc acagatgagc ttgtggtcat tgatgtaaat 311461 aaagaaaaag caatgggcga tgtgatggat ttaaaccacg gaaaggcgtt tgcgccacaa 311521 ccggtcaaaa catcttacgg aacatatgaa gactgcaagg atgctgatat tgtctgcatt 311581 tgcgccggag caaaccaaaa acctggtgag acacgccttg aattagtaga aaagaacttg 311641 aagattttca aaggcatcgt tagtgaagtc atggcgagcg gatttgacgg cattttctta 311701 gtcgcgacaa atccggttga tatcctgact tacgcaacat ggaaattcag cggcctgcca 311761 aaagagcggg tgattggaag cggcacaaca cttgattctg cgagattccg tttcatgctg 311821 agcgaatact ttggcgcagc gcctcaaaac gtacacgcgc atattatcgg agagcacggc 311881 gacacagagc ttcctgtttg gagccacgcg aatgtcggcg gtgtgccggt cagtgaactc 311941 gttgagaaaa acgatgcgta caaacaagag gagctggacc aaattgtaga tgatgtgaaa 312001 aacgcagctt accatatcat tgagaaaaaa ggcgcgactt attatggggt tgcgatgagt 312061 cttgctcgca ttacaaaagc cattcttcat aatgaaaaca gcatattaac tgtcagcaca 312121 tatttggacg ggcaatacgg tgcagatgac gtgtacatcg gtgtgccggc tgtcgtgaat 312181 cgcggaggga tcgcaggtat cactgagctg aacttaaatg agaaagaaaa agaacagttc 312241 cttcacagcg ccggcgtcct taaaaacatt ttaaaacctc attttgcaga acaaaaagtc 312301 aactaaccgc aactttagag taaagggctg attgtcaatg tgggagcagt tgtatgatcc 312361 gtttggaaac gagtatgtga gcgcacttgt ggcgctcact ccgattctct tttttctttt 312421 ggctttaact gttttgaaaa tgaaaggcat tcttgcggca tttcttaccc tagccgtcag 312481 tttcttcgtc tccgtttggg catttcatat gccggttgaa aaagcgattt cttctgtttt 312541 gttaggaatc gggagcgggc tgtggcccat tggctacatc gtcctgatgg cggtgtggct 312601 gtataaaatc gccgtgaaaa ccgggaaatt taccattatt cggtccagca ttgccggcat 312661 ttcgcctgac caacgattac agctattatt aattggtttt tgttttaacg cgtttttaga 312721 aggcgcggcc ggttttggtg ttccgattgc gattagtgcg gcgctgctcg tcgaacttgg 312781 ttttaaaccg ttaaaagcgg cggcgctctg cttgattgca aacgctgcct ccggagcctt 312841 tggggcgatt gggattcctg tcatcacagg ggcgcagatt ggtgatttgt ctgctcttga 312901 gctgtctcgg acattaatgt ggacactgcc gatgatctca tttttaatac cattcctgct 312961 tgtattctta ttagaccgaa tgaaaggaat caaacagaca tggcccgctc ttctggttgt 313021 gagcggtggg tatacagcgg ttcagacact gacaatggcg gtgctcgggc cggaattagc 313081 aaacattttg gcggccttat tcagcatggg cgggcttgcc ctcttcctcc gcaaatggca 313141 gccgaaagag atttaccgcg aggaaggggc cggcgatgct ggtgagaaaa aggcataccg 313201 tgccgctgac attgcgaaag cgtggtctcc tttctacatt ttaactgcgg cgatcaccat 313261 ctggagcctt cctgccttca aagcgctttt ccaagaaggc gggctgttat atcaatcaac 313321 gctcctgttc aaaatgcctt ttctgcatca gcaaattatg aaaatgccgc cgattgcgcc 313381 atctgccatg ccgttagatg cagtctttaa agttgatctg ctgtcagcga ctggtacagc 313441 gattttagcg gcggtcatcg tgacagggct gttcagcaaa aagttctcct ctcgggatgc 313501 ctttgcttcc ttgaaggaga cgggaaaaga gctgtgggtg ccgattatga cgatctgctt 313561 cgtgatgggg tttgccaatc tggccaactt cgcagggctc agctcttcaa ttgggttagc 313621 attggcgaaa acaggagacc tgttcccgtt tgtcagtcct gttctcggct ggattggcgt 313681 gttcatcacc ggttctgttg tcagcaataa tgctttgttc ggccatttgc aggttgtcac 313741 gggagcgcag atcggtgcgg gttcagattt gctgttagcc gcaaatacgg cgggcggtgt 313801 catggcgaaa cttgtttctc ctcaatctat cgccatcgct gccgcagcgg tcggccaaac 313861 aggcaaggaa tctaaactgt ttaaaaggac agtggcgtac agcctgattc tgttattgat 313921 catttgtata tggacgttta ttcttgcaag attaggagtg taatagaaaa aagcagtaca 313981 tgcccagcat gtactgcttt ttttatgtta atttgctttc tttgtcattt cggctgttgt 314041 tttcactctg gcttttccca taaataaaat ggtaaccgcc gcgaggacaa ttggaatcaa 314101 agcgagcaaa aagacatacg tgatacttga tgacatcgcg tcaataatgc gattcaggat 314161 cgcatcagga atctgggaac gtgttcccgc ttggaatatc tcctgcgggt cgccaatatt 314221 ttgcgcagcg cctgatcccg ctgagccttt cataccgctg aaggcgtcat tcagcttgtt 314281 tgtgaatacg tttgtttgca ccgttccgaa aatggtgaca cctaaggtca tgccaaatga 314341 tcgcaaaaat gaatttgtag agtttgccgt tccccgaaag cgaggttcaa gatcattcat 314401 cgatgccgcc ggcagcaggg agaagttaaa gcctacacca aagcctgaaa tcatcataaa 314461 gactgtcagc catacccgtg ctgtgtcagg cgtcatattg gaaagaagca gcatgccgat 314521 aaagaaagct ataacagata tcagcatcaa attgcggaag cttgccttcg tttggaagat 314581 cccgccgatc atgcttccga tgactgatcc aatcatcatc ggcgtcagaa tgaagcccgc 314641 gcttgtcgcc gagctgccgt agaccgcctg aacgaaaatc ggaataaata ccgctaaaat 314701 aataaatgtt ccgccataca ggaaagcgag aatctgtgct gtggcaaaca agcggttctt 314761 aaacatccag aaagaaataa tcggctcttc tgcttttctc tccacaataa aaaaggcaat 314821 gaagaaaacg gcgaatacaa taaacagccc gatgatctga atggagttcc aatcgtatgt 314881 tttgccgcca agctcaaggg cgaacatcag gcatacaatg gatacgacta aggtaatcgc 314941 gccgccccag tctattttct gctttctgtg ctccagagat tctttgtagt agcgaataat 315001 gaaaaacaat gacaatgcgc cgatcggcac attgatgtaa aacacccagt gccagctgat 315061 cgaatctgta atgatcgcgc ctaagagcgg accaagaaca ctggataatc caaatacagc 315121 accgaacatg ccggacattt ttccgcgttt ttccggcgga aacaaatcaa agataatggt 315181 aaaggcaatc ggcaggagcg cgccgcctcc gatcccttga atggcccgga agatgatcag 315241 ctgattcatc gtctgggcaa tcccgcataa agcagaaccg attaagaaaa aaataagtcc 315301 aaacaggaaa aaacgttttc ggccgtacat atcggaaagc ttgccgtaaa tcggcatgcc 315361 agccataacc gccaccatat aggatgccgt cacccaggca aatttatcga agcttccaag 315421 atcggctacg atattgccca tcgcggtggc aacaatcgta ttgtccattg cagacatcaa 315481 gatgcccagc aggagaccga ggaccacaaa tttggtggaa gcctgttttg ctgttgttgt 315541 gtccatttgt tctacctcct cttacttttc tatgtaagtt ctgatatcat gataatagtt 315601 tgattgttga atatctcgat tatcaagata aactcgattt tatagggagg actgtcagtt 315661 gtcaacaaga aattccagaa gtgagttgga aaagactgct gttcagcttt ttcgaaaact 315721 gggcacaaga acggttctgt ttcatcaggc agccgctcaa gctctcggtc tgtttcccac 315781 cgatttgaaa tcagctgaca ttttaaatga agcagggccg atgacggccg gagagctggg 315841 gaaaaaaacc ggcctcagca cgggttccgt cacggcgctt gttgaccggc tggaaaaagc 315901 ggggtatgtg gctcgtgaaa aggacccgaa cgatcgcagg agagtcgtaa tcgtcccttt 315961 gactgcttcg aaaaaacata taaaggattt gttccgtcct ctgtctgagt caacgatgga 316021 tttgtgccgc gaatatacgg aagaggagct ggaactcatt ttcagttttg taggcaaagc 316081 tgccgatatt atggaggaag agcttgaacg tctgaaacag taagtgaatt tgtgcatagc 316141 ttggcccgtt cccgaataaa ttgtacaagt tacataagag aagggagtac gggccggtga 316201 acattttttt gagctatatt gtgctgggac tgtccttgtc tgcgcctgtg gggccagtga 316261 atgcggcgca aatagacaaa ggaattaaaa acggtttttg gcatgcatgg attttcggtt 316321 taggcgccat gacagcggat gggctgtaca tgctttttat ctatttcggg ctgtcgcagt 316381 tcttgaccgc tccatttgtg aaaacgtttt tgtggctgtt cggctttttt gtcctgacct 316441 ataccggaat tgaaacgctg aaaaacgtca gagaaccgat ggatgtgcga agctcgcggg 316501 ggaaaccgtc atacaggaaa acattcgcat cgggttttct catttcattg tcaaacccat 316561 tgagcatcct tttttggctt ggaatttacg gaagcattct tgcgaaaaca gcagaggcct 316621 acaatatgaa tcagcttcta atctatagct ccggcatcat gatcggcatt ttaatctggg 316681 atttctgcat ggctatcaca gccagtacgt tcagaaacct gcttcatgaa aagctattga 316741 gaggattgac cggaatcgcc ggtgtatccc tccttgtgtt tggcttttac tttggttatc 316801 agggcatcaa acagttattg ggctgattca tgaaggacag tcacctgccg cttccagttt 316861 taatatagta tccagatgat actggaggtg gatcaatggt gaatgggatt tacaccaaaa 316921 gttttctgga acgtattcag gaagagcttc ctgaatggca aagaatcgct tttgagctgc 316981 tggcagaaac tctgggggac gacgcggata catttccgtg cattcccgga cgccaggcgt 317041 ttctgactga tcagcttcgg attgcttttg ccggagatcc gcgggaaaac cgcacagcgg 317101 aggaactggc tccgttgctt gcggagtacg gcaagatatc gcgggacacg ggaaaatacg 317161 catccctcgt tgtgttgttt gatacaccgg aagatttggc ggagcattat tcgattgaag 317221 cgtatgaaga gctgttttgg cgctttttaa atagactgag tcatcaagac gaaaaagaat 317281 ggccggaaga cattccggcc gatcctgagc attataaatg ggagttttgt tttgacggcg 317341 agccgtattt cattctgtgc gctacaccgg ggcacgaggc aagaagaagc cggagctttc 317401 ctttttttat ggtcacgttt cagccaaggt gggtgtttga tgacctaaat ggatcaactg 317461 catttggccg taacatgagc aggctgatcc gatctcgttt agaggcctat gatcaggctc 317521 cgattcaccc gcaattaggc tggtacggag gaaaagataa tcgtgaatgg aagcagtatt 317581 tcctccgtga tgacgaaaaa caggtatcga agtgcccgtt ttcttattta aagaacatgt 317641 tcaacaaaat gaaataaatc aaggactggc agggcgatct ttatgaccct gctttttttg 317701 atagatcatg gtaacgatgg cgataatcac gagaaaacct atgctgacga aaaaaccggg 317761 ccggcttgat ttttcaaaca atgtaccgga cacagctgca gcaatcagaa ccatcgctaa 317821 ataaatttgc gtttttccca tgccctcggg atcagtcagc tttttgctgg agaacaggat 317881 aaacagccaa gtgtataaaa gcataagccc cgcagctgtt gtcatatgct cataaatgtt 317941 tttaggcagc actaacgaca aaataatgga gaggacaagc cccgcaaacg tcagcccaag 318001 tgccggccag catatttttt tgccttcctt tagagtaaag catttcggcg cgtcgccgtc 318061 atcagccatt gtacaaagca atgtcgtaac cgcaaatagc gaagcgacaa gggtcgagaa 318121 ccctgcgatg atgaaaatcc cgttaaatat atcaaggatg atctcaaggt tatatccttt 318181 taatgacgta atgaacggac tgtcctgttc agtaaacgtg tgtaacggaa ccaaaagcag 318241 agcaagcccg attgaaatga tataaataat cgccagcgtc gccagcatca gtttccctga 318301 tttagacgct tcctcaggtt tttttaagtg aaccgccatc agccccatga cctcaattcc 318361 gccaaaagcg taaaacgcgt agattaaacc tgtccacagc cccatggcgc cgtatgggaa 318421 aaactcactc gtcttatttg gaacatgtat gccatgattt ccgccggaca ggataccgca 318481 taaagccagg atggcaatga caataaacat aaaaatagca gctgttttaa tgactgccag 318541 cacgttttct gttttttcaa agacggacag gccggtgaaa ataataagga gcccaagtac 318601 tgcgtagatt gaggcaaaca cccatagcgg cacttgagga aaccaatgct tcgtaaagag 318661 cgaaatggct gtcagctggc ttccggtaat cagcatttct gatgtccagt acacccagcc 318721 gttgctgaag cctgcccatt tgccgaatgc ttttcgggca tacgcacaaa acgagccctt 318781 ttccggctgc ttcgccgata gcttggcgag ctgttcaaag acaaaatacg taccgatccc 318841 tgcgatcaga aatgaaagga gaacggaaaa accgcttttt acaattgcga tgctggaacc 318901 gagaaagaag cctgttccaa tcgtgcagcc gactccgatc agtgacagct gccaccaagc 318961 cagattccct tttggctggt ctttttttgt ttggctcatt atttattcaa ccccttttat 319021 ctaaggttag attgtgatct gtccaaagct tatatacatc ggatttttgc ctctttttac 319081 atggagaagg aagcagacgc tcatactaat gaaaaaagga gcaaaccaat gacacagcaa 319141 tatattgtgg agccgaaaaa agggcttggg ctgaagctga aaaaggggca gattttaaag 319201 gtggttgatg tagaagggca gcaggtggct gattttgtcg cataccatgc caaggatttt 319261 tatgaacacc ttgatcaggg agcgacgata gacgccaatc actccattca tgtgaaggtc 319321 aacgaccatc tctactccaa cctgtataag ccgatgttaa ccctgattga agatacggtc 319381 ggcaagcatg atctgctgtt gcccgcctgc cgtcctgata tgaacaggct cttatatggg 319441 aagcaaaagg atgagtttca ggatacgtgc tatgacaata tgaaccgtgc gcttgagcag 319501 tttggcgtac cgaagcccca catgcattac ccatttgcga tttttatgaa tactgtcctt 319561 gatgagaaag ggaatctgtc tgtggaaacg ccgctttcga atgccggaga ttatgtaagg 319621 ctcagggcgg agatggattt aattgtcgcg ttttcttcct gcccgattga aaaagggaaa 319681 tgcaatggcg acagtgtgac atccatacgg gttgaagtca gctgatctct cttgttcaca 319741 gtgaatgaag acctgtgcta tatttaatag ggatacataa cagtcatgat tcattttcat 319801 tgatttaggg aaatgatcag taataaggga aaatgtacag gaggaatgat tgggatgagc 319861 atgcaggaaa agattatgcg tgagttacat gtgaagccct caattgatcc aaagcaagaa 319921 attgaggacc gagtcaattt tttaaaacaa tatgtaaaga aaaccggtgc taaaggcttt 319981 gtattgggaa tcagcggggg ccaggattca acacttgcgg gaagactcgc tcagcttgcg 320041 gtggagagca ttcgcgagga gggcggagac gctcaattta tcgcggtccg tcttccgcat 320101 ggcacacagc aggatgaaga cgatgcccag cttgctttga agtttattaa gccggataaa 320161 tcatggaagt ttgatattaa atcgacagtc agcgcttttt ctgatcagta tcagcaggaa 320221 acaggcgatc agctgacgga ctttaataaa ggaaacgtaa aagcaagaac aagaatgatc 320281 gcgcaatacg cgatcggcgg ccaggaaggt cttcttgtgt taggaacaga ccatgctgct 320341 gaagcagtga ctggtttctt tacgaagtac ggtgacggcg gagcagacct cctgccgctg 320401 acaggcttga cgaagcgcca gggaagaacc ttgctgaaag agctgggtgc accggaacgc 320461 ttatacttaa aagaaccgac tgccgatctg ctcgacgaaa aaccgcagca gtcggatgaa 320521 acagagcttg gcatttccta cgacgagatt gacgattatc tcgaaggaaa agaagtatca 320581 gcgaaagtat cagaagcgct ggaaaaacgc tacagcatga ctgaacataa acgccaggtt 320641 ccggcgtcta tgtttgatga ctggtggaaa taagttgaag aaagcccgct ctcggagcgg 320701 gcttttgtcg tgtacagaag ctttatttga tgcggatatg attcagcttt accattaatc 320761 tgtcggcgaa ccttcggagg ctgcctcttg tatcaggatc taatgggagt tcggctctcg 320821 cggcaatgtt ctctgccaca tcctgaatcg acaggttgtc tgtttgaatg tggtcctcaa 320881 aaatgggtga tgataatcct tcaacacagc ggtcaatttg tttggcggcc catgagtttt 320941 ttccttctgc tctggtgcgc agccttttta acaaggtttc ctttgaagcc attagtgtaa 321001 agtggtgaac gatcctgcct tcctgtctga gcctgccgat gatctcattg aagtattcag 321061 ggtgtacaat cgtcataggc acaataagga tgccgcggta tgtatctgtc agagaagcta 321121 gcaaactgta attgaacgcc cgccataaag gatagctttg aaaatcgtcc tttgcgatct 321181 cctgcggcac catggagcgc agcgcaaaac ccattttctc gggatcatac acgtaagatg 321241 ggttcagcct tctgtgcagt tcgaaggctg tttgtgtttt tcccgaaccg aatgccccgt 321301 ttatccaaat gatcatcgcc atttctccct tcctatttat catacagaaa aagacccttc 321361 catcgaagag tcagctggaa aaacaataaa ggcggaaggt tttaacgctt ttttgcgtcg 321421 aagtattaaa atacctgcag aaatgttgta caatgaatgt cattcaggca aaaatggcta 321481 caacaaagcg cactataagc ttgaccggta aagccggtat ctatataaat attcgctaaa 321541 taagcatata atgaatatat aatttcattc cttaggagga tttcgccgaa gatgaacgct 321601 aaacgagcca tcccagtaag agaaagaaat atcgtcctga tcggattcat gggtgtagga 321661 aaaacaacaa tcggccaatt ggtcgctaaa aaattatata gagattttat tgatattgac 321721 cagcagatcg aaaaggattt caatatgtca attcctgaga tatttgagaa aaagggagaa 321781 gactttttcc ggaaaacgga gaaggaatat attttagaca tctgccatca taaacgattc 321841 aaaatcgtat ctctgggcgg gggatctttt aaacaagaag aaatcagaaa ttgctgtctg 321901 gaaaactgtc tcgtgcttca tctggacctg tcatgggaga actggaagca gcgcgcggat 321961 ttattgatcg aaagccgccc tgtactgcat aaccgttcaa tggatgaaat ggaacagctg 322021 tttaacgaaa gaaaagtcat ttatgacaag cacaattcaa aagtggcaac agacaacctt 322081 tccccggaag aggttgccga ttacattgtt gagacattaa aaattggctg ggatctttat 322141 cagccgatgt aaaaagccgt gcgcagcgca cggctttttt tatcgtttta tcccttgtat 322201 caaaatcgct tttaaacaaa aggagatggg ctgtccgttt tggttcaatg taatacagaa 322261 cgtgtcgcgt gcttcgtctg atgcgtgatt caagtgggta atgatttgtt tttctcggtc 322321 agcgggggtt ccgcctcgtt tgatccagct atcgtattga atcggcaagt tccacttttg 322381 gatgtcttga taggccagtt gattggcgct gaacatcgcc tgccattctg ataatgagct 322441 ttcacgaaca tgggaagggt ctcgaagccg gttcaaatga ttgacaaact catcaagaac 322501 gggatcttca ggcgcgtaat gatcaactaa gagaaaacgt ccgtcctgtt ttagtacgcg 322561 tgcaacctct ctgacagctt tgcggacatc tgaaaaatgg tgggctgcgt atcggcaggt 322621 gatgatgtca aatgaatcgt cggggaaggg gagtgactct gccgttcctt gctgaaagcg 322681 tacgttttca actccttttt cttgcgcgaa ggaggacgca acctcaacca tctctttcgt 322741 tgcatcaaca ccgatgcact cctgtacata aggagaaaat gccagcgccg tatggccggc 322801 gcccgctcct atatccagca ctcgatgctc tgcccggcat tccgctgttt tgatcatcaa 322861 ccccaaatct tccccctcgg caaatacctt ttcatcccga tacatctcgg cgtttttaga 322921 aaacggtgtt tcatttgtca tttgaaccag ctccttcttt tcgtaaatga tgatatggat 322981 tatgttagca atttctgtta tgattcgtcc aagatataaa aatgatgaaa atgataggtt 323041 caacctatgg aggctgaaat ggatattaaa gtgatggaat atgcagcgga aattgcccgg 323101 cgccaaagct ttacaaaggc ggcggaacat cttcatatcg cacagccgtc tctcagccag 323161 caaatcaaaa agcttgaggc tgagctgggg cttacccttt ttcacagatc ccatggctct 323221 gttacactga cacctcacgg caggcgtttc attgaaaaag ccgaggacat cattcgttcc 323281 agagatgatt tgcttcggga aatgcaggag cgatcacagg gaatcggtca taaattatcc 323341 atcgggattc ctgctgtaac agggagatat ctctttcctc cgctgctgaa gcagtttttg 323401 gcgcgctatc ctcatgtgga ggttcagctt gttgaaaaag atccggtttc attagagaag 323461 atgacggcaa agggagaagt tgacctttct gttttatcct tgcccatcga ggatgaacgg 323521 ctctccatta cacccttgct cacggaaccg gttgttctcg cggtgccgaa ggaaaaacaa 323581 aggtggatgc cgccggaatt ggtcgcgctg attgagaaag cgctggaaga agatgaggga 323641 cgccagccgt gtgtgccgat tgacatggta aggaacgtgc cctttattct gttaaaagaa 323701 ggcttcggct ttcgcaggac agttctcgat ctctgtgcgg aaagcggctt taagccgaat 323761 gctgccttta agacgagcca tattgaaacc gcccaatctc ttgtggctaa cggattaggt 323821 gtgacaatgg caccgaatat ggtcagaagg gataaagatc cgggtgtgat ctatttatcg 323881 attcaatccg cgccatcacg aaccctcgtc tttgtctttt taaagaaccg ctatgtcagt 323941 ctgacggccc aggcctttat ggaactaagc cgggaaagtc ttaaacaaac gtttgatgaa 324001 ggctgtctgg gaaacaaaga tgaaaatatt tagaaaacaa agacgaaacg tggtagtata 324061 ggaatacaaa ctaaatctta taaaacaaag gggaataatc ggaaatgcaa ctattcgatc 324121 tgccgctcga ccaattgcaa acatataagc ctgaaaaaac agcaccgaaa gatttttctg 324181 agttttggaa attgtctttg gaggaacttg caaaagtcca agcagaacct gatttacagc 324241 cggttgacta tcctgctgac ggagtaaaag tgtaccgtct cacatataaa agcttcggaa 324301 acgcccgcat taccggatgg tacgcggtgc ctgacaagga aggcccgcat ccggcgatcg 324361 tgaaatatca tggctacaat gcaagctatg atggtgagat tcatgaaatg gtaaactggg 324421 cactccatgg ctacgccaca ttcggcatgc ttgtccgcgg ccagcagagc agcgaggata 324481 cgagtatttc accgcacggt cacgctttgg gctggatgac gaaaggaatt cttgataaag 324541 atacatacta ttaccgcggt gtttatttgg acgccgtccg cgcgcttgag gtcatcagca 324601 gcttcgacga ggttgacgaa acaaggatcg gtgtgacagg aggaagccaa ggcggaggtt 324661 taaccattgc cgcagcagcg ctgtcagaca ttccaaaagc cgcggttgcc gattatcctt 324721 atttaagcaa cttcgaacgg gccattgatg tggcgcttga acagccgtac cttgaaatca 324781 attccttctt cagaagaaat ggcagcccgg aaacagaagt gcaggcgatg aagacacttt 324841 catatttcga tattatgaat ctcgctgacc gagtgaaggt gcctgtcctg atgtcaatcg 324901 gcctgattga caaggtcacg ccgccgtcca ccgtgtttgc cgcctacaat catttggaaa 324961 caaagaaaga gctgaaggtg taccgctact tcggacatga gtatatccct gcttttcaaa 325021 ctgaaaaact tgctttcttt aagcagcatc ttaaaggctg ataaatgtga aaagccgccg 325081 catatcatca ggcggttttt ttctgcaaac tgccggaatg agaacagact ggagacgaat 325141 agatatgaaa caaagaatca ttgatgaatt aaaacggatc gagcagtcat acggagtcaa 325201 aatcgtgtat gccgtcgagt caggaagccg cgcatgggga tttccctcgc aggatagtga 325261 ttacgacgtc cgctttattt atgttccgaa aaaggagtgg tacttttcaa ttgagcagga 325321 gcgtgatgtc attgaggaac cgattcacga tttgctggat atcagcggct gggagctgag 325381 aaaaacgctt cggcttttca aaaagtcaaa ccctccgcta ctcgaatggc tgtcctcaga 325441 cattgtgtat tatgaagcat ttacgaccgc agagcagtta agaaaactcc gcacggaggc 325501 atttaagcct gaagcaagcg tgtatcacta tatcaatatg gcgagaagga acgtcaagga 325561 ttatctacaa ggacaagagg tcaaaattaa aaagtacttc tacgttcttc ggcctatttt 325621 ggcctgccaa tggattgaaa agcacggaac cataccgcca atggacttta ctgttttgat 325681 gaatgaactt gttgctgaac ccgagctgaa ggctgaaatg gaaaccttgc ttgaacggaa 325741 aagaagaggg gaagagcttg acctcgaagc aagaatcgat gttattcacc aattcattga 325801 aacggaaatc gaaagaatca tggaagcggc aaaagaactg aaggcagaga aaaaagatat 325861 gacatctgaa ttgaaccgtt tgcttttgaa tacggttgaa gaagtgtgga aggatggagg 325921 aagctgatgt tttttgtcgc ttccttttct cctttattcg acagaatccc cccccgactt 325981 tctaactatc tgattgtggc aaacccacaa aaataatcag aatctttgta ttttgagaat 326041 attgtgaacg ctggttttgt ccatttacaa taaactcata caaatacttc ttagattgcg 326101 gggtgttgag gttggaagtg atcacaagag attttttctt atttttatcc aaaagcggct 326161 ttctcaataa aatggcgagg aactggggaa gtcgggtagc agcgggtaaa attatcggcg 326221 ggaatgactt taacagttca atcccgacca ttcgacagct taacagccaa ggcttgtcag 326281 ttactgtcga tcatttaggc gagtttgtga acagcgccga ggtcgcacgg gagcgtacgg 326341 aagagtgcat tcaaaccatt gcgaccatcg cggatcagga gctgaactca cacgtttctt 326401 taaaaatgac gtctttaggt ttggatatag atatggattt ggtgtatgaa aatatgacaa 326461 aaatccttca gacggccgag aaacataaaa tcatggtcac cattgacatg gaggacgaag 326521 tcagatgcca gaaaacgctt gatattttca aagatttcag aaagaaatac gagcatgtga 326581 gcacagtgct gcaagcctat ctgtaccgga cggaaaaaga cattgacgat ttggattctt 326641 taaacccgtt ccttcgcctt gtaaaaggag cttataaaga atcagaaaaa gtagctttcc 326701 cggagaaaag cgatgtcgat gaaaattaca aaaaaatcat ccgaaagcag ctcttaaacg 326761 gtcactatac agcgattgcc acacatgacg acaaaatgat cgactttaca aagcagcttg 326821 ccaaggaaca tggcattgcc aatgacaagt ttgaatttca gatgctgtac ggcatgcggt 326881 cgcaaaccca gctcagcctc gtaaaagaag gttataacat gagagtctac ctgccatacg 326941 gcgaggattg gtacggctac tttatgagac gccttgcaga acgtccgtca aacattgcat 327001 ttgctttcaa aggaatgaca aagaagtaaa aaaggagaga ttatcatgac aacaccttac 327061 aaacacgagc cattcacaaa tttccaagat caaaacaacg tggaagcgtt taaaaaagcg 327121 cttgcgacag taagcgaata tttaggaaaa gactatccgc ttgtcattaa cggcgagaga 327181 gtggaaacgg aagcgaaaat cgtttcaatc aacccagctg ataaagaaga agtcgtcggc 327241 cgagtgtcaa aagcgtctca agagcacgct gagcaagcga ttcaagcggc tgcaaaagca 327301 tttgaagagt ggagatacac gtctcctgaa gagagagcgg ctgtcctgtt ccgcgctgct 327361 gccaaagtcc gcagaagaaa acatgaattc tcagctttgc ttgtgaaaga agcaggaaag 327421 ccttggaacg aggcggatgc cgatacggct gaagcgattg acttcatgga gtattatgca 327481 cgccaaatga tcgaactggc aaaaggcaaa ccggtcaaca gccgtgaagg cgagaaaaac 327541 caatatgtat acacgccgac tggagtgaca gtcgttatcc cgccttggaa cttcttgttt 327601 gcgatcatgg caggcacaac agtggcgccg atcgttactg gaaacacagt ggttctgaaa 327661 cctgcgagtg ctacacctgt tattgcagca aaatttgttg aggtgcttga agagtccgga 327721 ttgccaaaag gcgtagtcaa ctttgttccg ggaagcggag cggaagtagg cgactatctt 327781 gttgaccatc cgaaaacaag ccttatcaca tttacgggat caagagaagt tggtacgaga 327841 attttcgaac gcgcggcgaa ggttcagccg ggccagcagc atttaaagcg tgtcatcgct 327901 gaaatgggcg gtaaagatac ggttgttgtt gatgaggatg cggacattga attagcggct 327961 caatcgatct ttacttcagc attcggcttt gcgggacaaa aatgctctgc aggttcacgt 328021 gcagtagttc atgaaaaagt gtatgatcaa gtattagagc gtgtcattga aattacggaa 328081 tcaaaagtaa cagctaaacc tgacagtgca gatgtttata tgggacctgt cattgaccaa 328141 ggttcttatg ataaaattat gagctatatt gagatcggaa aacaggaagg gcgtttagta 328201 agcggcggta ctggtgatga ttcgaaagga tacttcatca aaccgacgat cttcgctgac 328261 cttgatccga aagcaagact catgcaggaa gaaattttcg gacctgtcgt tgcattttgt 328321 aaagtgtcag actttgatga agctttagaa gtggcaaaca atactgaata tggtttgaca 328381 ggcgcggtta tcacaaacaa ccgcaagcac atcgagcgtg cgaaacagga attccatgtc 328441 ggaaacctat acttcaaccg caactgtaca ggtgctatcg tcggctacca tccgtttggc 328501 ggcttcaaaa tgtcgggaac ggattcaaaa gcaggcgggc cggattactt ggctctgcat 328561 atgcaagcaa aaacaatcag tgaaatgttc taagcgggac taaatgggca tcctccctgc 328621 gggggtgtcc atttcatcca tatactataa aaaagaggag gaagtgccat agaaaacaca 328681 cagctgatta tttcgatttg tatttatatg gcgggaatgc tgctaatcgg ctactttgct 328741 tacaagcgta cgtcgaatct gacggattat atgctgggag gacgctcttt gggtccggca 328801 gtaaccgctc tcagtgccgg cgctgccgat atgagcggct ggctgctaat ggggcttccg 328861 ggcgccatgt tttctactgg tctgagcggc gcttggatcg tcatcggact ttgccttgga 328921 gcgtgggcga actggcttta cgtcgcacca cggctgagaa cctatactga aaaagcgggg 328981 aattctatta caattcccgg attcctggaa aatcgcttcg gagatcaaac aaagcttctc 329041 agactgtttt cgggaattgt cattttagtc tttttcacgt tttatgtatc gtccggaatg 329101 gtgtccggcg gcgtcttatt caacagcatc ttggggatgg attatcacac cggcctgtgg 329161 attgtgacgg gtgttgttgt ggcatatacc ctgtttggcg gctttttggc agtcagctgg 329221 acagattttg ttcaggggat tattatgttt gccgcactca ttcttgtgcc gatcgttacg 329281 tttttccaca cgggaggagc aggtgataca gttgctgaaa tccgctctgt agatcctgat 329341 atgtttaata ttttcaaagg aacgagcgtc cttggcatta tttctttgtt tgcctggggg 329401 ctgggatact ttggccagcc gcatattatt gtgcgtttta tggcgataac gtctgtcaaa 329461 gagatcaaaa gagcgcgcag aattgggatg ggctggatga ttttgtctgc agtaggcgca 329521 gtgctgaccg gtttgggcgg aatcgcttat taccatcagc gcggcatgac actgaaggac 329581 ccagagacga tttttattca attagggaat atcttgttcc atccgattat cacgggtttt 329641 ctgatttcag cgattttggc cgcgattatg agtacaattt cttcccagct gcttgtgaca 329701 tcaagctctc tggtagaaga tttgtataag tcgatgttca gacgctcagc ttcagataaa 329761 gaactggtgt ttttaggccg actggctgtt ctggctgttt caattgtcgc gttggttctg 329821 gcttgggaga aaaataacac catccttgga ttggtcagct acgcgtgggc gggcttcggt 329881 gcatcattcg ggccagttgt actgctcagt ctgttttgga aacgaatgac caaatggggg 329941 gcactcgccg gcatgattgt gggagcagcg actgtaatca tttgggcgaa tgccggtctt 330001 tcggactttc tgtatgaaat gatacctggt tttgctgcga gtctattatc tgtctttttt 330061 gtcagcatat tgacgcaggc tccgtcacaa gctgtcacag accagttcaa cgactaccaa 330121 gatacaatgt cgcaataaag atcgaaagga ggaggaaggg gctgtccctt tttcctcttt 330181 tctcctttta agcggccatt tttttctttt ggaaacaaac gtattttttt ctatacaaaa 330241 agaccccgta tggatatgat taaagtaaaa aaagtatagg agaaaaaggt atggaagagc 330301 ttttagagag agttttttca ttttcagatg ttgataagct aattgatttt attagctatg 330361 aactgcaaaa gccagtgata ctggaaagcg cggatttctt tttgttagcc tataattctt 330421 actatattaa ccattttgat tctgccaacc agcagactat tttttcgaaa aagtgtccgg 330481 tccagatttt tgagaggttt ctgaaggacg gaattattga aaaattgaaa acagagcctg 330541 agccttttcg cgtcaataaa attgaaagca ttgggttaaa ccagagggtg gtcgtgagtg 330601 caaagcacaa aggggaagtc atgggctaca tctggattca ggagctggac caaaatctga 330661 cggatgaaga gctcgacttt ttgtacgaga cctccttcca tgtcgggaaa atcatttata 330721 aaacgaataa attgaaacag gaaaaggaag aaaaagcaga ggatctcatc aaacgggcga 330781 tctatcagca atttacctct gagaaggaac tcagacggga agctgaaagg atcaacaccg 330841 tgctgccttc catgttttca gttgttatcc tgcacgccgc aaatggggat ggggaagcgg 330901 ttgaggattt aaaggaaaat atcaggtcgt acctgaattt acgggataag gtcagtcatg 330961 tcttaacgat cgaatcaaac attgtcatcg tcgtagcgag tttttcccaa aaaagctccg 331021 tctcctcagc agcttctgag tttattaaca agctgttaac acattttcac tttcaaaaaa 331081 tacctacccc tatttatatc ggtatcggaa acgaatataa tcacctatta aaacttggca 331141 agagctacac agaagcactt gaagtcatca aagccgcaga aatcaccggc aatcaggaaa 331201 acattccata tgaatatgcc aaactcggca tttaccgcta tttagaaagc atcgaacaga 331261 aaaatgaatt tttagaatac gagaataaag atttagcttt attaaaagca aaagacgaag 331321 aaagcagcac tgagctgctc aaaaccttgg aaatctatct cctcaacaac tgcaaaacaa 331381 aaccagcggc agaacagctg tttattcacc aaaatacatt gaattaccgc atcaaacaga 331441 ttactgagat gacgtcgatc gatttaagcg atttcagaac gcggtgccag ctctatctcg 331501 atttgatgct gatgaaaaag aaataaaaaa gaaaccagta cttgtactgg tttcgtcttc 331561 acttaaaatc ctctgtaaac atacggatca tcaggttttt taatggtatt ccagtcagtt 331621 actttgacga cagggagagt tgacttgaat ggctggtaat attctgaggc cagagtgccc 331681 ttaatgtgaa tccattcatc atccttgatg tccatgtcct tcggaaattc cacaagcatc 331741 ccgtacacgc cggaatcagc gatacagtga atgatgccaa accttaatac gaacagctga 331801 tttttgttaa ttgcgtttcc tttgtaagca aatccatgaa attctatcgt ccgtccgaga 331861 aattcacccg gatagttata gatggtttcc attcctttta ggaaatcgtc atcggtcaga 331921 gaaatctctt ttttgctgga atacttatta aacagctgtt tcatttgttt gtcatagctg 331981 tcttgcgcgt aataaaggct ggcatcaggc cgcaaatact gtgtttggga gtagtgatct 332041 ccgctctcca tcgccttaaa cgagaaccct tttgttttga ctatggatga gtcaagcgtt 332101 gcaatcggga agaagatgcc tgacaccaaa ggaaaaagaa aaacaacata aatcaaataa 332161 cgctgataaa atggcttgtt ttgttcatgg tcatgctcgt gatcatggcc gcacccgcaa 332221 tcatggtcat ggtgatgtcc gcttttttca ggcgacttga taaatagata tgcttggacg 332281 gcggtcagaa tggccagcag gaagatcgca ataaaggaaa gataggcata tttcatattg 332341 atatattttg ttagatttcc tgaggcatgc agatgataaa agaaaaacgt aaatcccatc 332401 agcaccaata aacgaaacat ccaatcaccc ctttaccagt agtgatcccg ctaaaacaat 332461 cacgacaatg tatgtaatca gcaggaaaac aaatcgtttt ttgaaggccg caagcatcat 332521 caatagattc ttaatatcca ccattgcacc aaagacgaga aaggcgatta acgatcctaa 332581 tgaaaacgtg ctgctgaagg aagacgcgat gaacgcatca acttctgaac aaagcgacag 332641 gacaaacgcc agacccatca tcacgaggga agaggataca tcattctgcc cgatcgcaag 332701 cagagtggat gttttgacat acgtctgcat agcggctgcg ataaaggcgc cgatgattaa 332761 atatttcccc acggagaaaa attcatcaat ggcatgccgc aaggtcccgc ccagtttttg 332821 gagcaaggtg ccgtgatgat gatggtggtg cccgggttca tcaggcttta aaagctggtt 332881 atccttaaat tgataggata agatgacccc gatgatcagc gaaacggcga gagccagtcc 332941 gcctctgtaa aagaccacgc tccatctatt cccgaacgca atataagtag aaaataaaac 333001 gataggatta atgataggcg cggtcagcat gaaagcaacg cccgcatgca gaggaactcc 333061 ctttaacaga agccgcctcg taatcgggat gatgccgcat tcgcaggcgg gaaataaaac 333121 gccggccagc gcaccgaata aaacggcgag aaaacggttt ttcggcatga ttcttgcaat 333181 catttcttca gaaacaaaca tttgaatgat tccggaaagt atgacgccaa tcagaataaa 333241 cggaatggct tctattaaaa tgctgataaa aatagaattc agctgaagaa aagatgattg 333301 tgctgtcaca ataaaacctc cgctcatgtt aagctgcctt tcttatgata ccagaaaaaa 333361 aggcactgct tgtttgacgg aggaggggaa aggatcgttt cactttggtt aggattccaa 333421 aaagccgagt aggatactgc ctgtttctgc agcttctttt ccgagccaaa tcaggtgtcc 333481 ccatgagtga agcaaacaga gaacagcgcc acgaatgtgc tcttttgcat gatgtgcatg 333541 tgacaagtca accaatccgt cataaacact ttgcataatc agcacgggac atatgatggc 333601 ttgcaggtct tttaaagaga cagcggcggt ttgtgacaag tcaatcagaa atccttcacc 333661 cgagcgctgc cggctgttca ttttccgaaa tgcttctatg tctttttcat tcatcaagga 333721 cttgattcgc tgaaacggaa gcgtgctgaa ttgggggctc atagctcgaa acatcaaacg 333781 cgggaaagcg ttattcaagg aagaaatcag cttccatatc cacttttcca ccggcgggcg 333841 gaagagaatt tcccccaatt tatattcagt gtcttttggg gtgagccact ctttggtgac 333901 tgcggattgc agggtcaatg tatttactct ttccggataa tgtgaggcaa agcatatgcc 333961 gctcggccct cctgctgaga tggcgatcac atggacactc tcgatttgta gatgatctaa 334021 taatttcaca tagaaacggc aggcattggc aagacttttt ccaatttctt ttgacgtccg 334081 tccatagcca ggccttgaag gcgtaatgat ggaataccct tgttcaatca acgctgtgta 334141 tccgaattcc tcgtaacaat ttgaatgccc gccatgcatg acaaggatcg gagttccctt 334201 gcctgtcaca gaatattcta gtgtaccgcc atcgaaggtg atcgtttcaa ctcgtctttt 334261 catctgtttc acccaattgg tttttgccta ttatagagtt ttcagcaatt gaccacaagg 334321 tagaagaaat gaataaacaa aggcccttga aatatgatat actttgtatt gatattcatt 334381 ctcaattaaa actttgatat agatgtgaac gggaggcagg acggatggct gagaatcaag 334441 aggtatatga cgttacgatt ataggcgggg ggccgatcgg gctgtttact gctttttact 334501 gcgggatgcg ggagctgaaa acaaaggtaa tcgaattttt gccgaagctc ggagggaagg 334561 tgtctttatt ctttcctgag aaaatcattc gcgatatcgg cggcataccg gggattgcgg 334621 gaaagcagct gatcgagcag ctgaaggagc aggcggcaac gtttgatcct gatatcgtat 334681 tgaatcagcg tgtgaccggg tttgaacgcc tagatgacgg caccattgtt ctgacgggtt 334741 ctgaagggaa aaagcactat acaagaactg tgattttggc ttgcggcatg ggtacacttg 334801 aggtcaatga gtttgacagc gaggatgcgg cccgatatgc gggcaaaaat cttcattatg 334861 gagtggagaa gctcgatgcg tttaaaggga aacgcgtggt gatatcaggc ggcggagata 334921 ctgcggtcga ttgggctaat gagcttgaac cgattgcggc gtctgtgact gtcgttcatc 334981 ggcgtgagga attcggcgga atggaaagca gcgtgacgaa aatgaagcaa tcatcggtgc 335041 gggtgcttac gccttatcgg ctggagcagt tgaacggaga tgaagagggc atcaaaagcg 335101 tgaccgtttg tcatactgag tctggccaga ggaaagacat agaaattgat gagctgatca 335161 ttaatcatgg gttcaaaatt gatctcgggc cgatgatgga gtgggggctg gagattgaag 335221 aaggaagggt gaaagctgac agacatatgc gaacgaatct tccgggcgtg tttgtggcgg 335281 gcgacgcggc tttttatgaa agcaagctga gattgattgc cggcggattt acggaaggcc 335341 cgacagcggt caacagtgcc aaggcttatc tggaccctaa ggccgagaat atggcgatgt 335401 attccaccca tcataaaaaa ttggtgcata aataaaacag cccttgagga aaagggctgc 335461 ttgccatcag gtgtgaagga gttttttctc tgcatgttga ttgtggatga aagctagcaa 335521 ttcatcctgt tcttgtacgg ctgtgaatcc ataaatgccg gcagctgagt catcgcctat 335581 gcagacgata ggagggcggc ttgctgacgg ttccggcaaa atgccaattt gttcgccacc 335641 attgatcaat tgctgaacgg acagcttgtt tgggcaaatg accatgtgca gcggggattc 335701 actgatggta cgctgaatca tgtgggtgaa ccggtcatct atgacgtttt catgagtgat 335761 ataaaacgaa caggattcat gcttttgcat gttttccact gcatggcggc tcccgacaac 335821 aagacgtttc tctgaatcag gctgaatggc ggtgacaaga aagccccgtt tctcaagctc 335881 tgtctttgct tgctcagatg ctgcactcag tttggctgtc agctggcgga tgtcgatttt 335941 ctgagaagcc agtgctctga aaaattcaca aaccgcccgg cgcgatgtga aaaaaacgtc 336001 ttcaaaggtg ccaatctttc gaagaatttc ttcattgaca ggcatgtttt cggtccgcca 336061 tttcggccac tcgatgagat cggcgccgga atcgcgcagc ttgtctgcaa gcgggtcttc 336121 atcttcgcca tgagtcacaa ccatcaaatg ccgtccgatg agcggtttgc tttcaaacca 336181 gctgtgtgtt tgaaagttga cgatgtctcc gatgacgata atcgcagggt ttgtaatctg 336241 gtgttcctgc actttttgct gaatgttctc aagtgttcct ttcacactcc gctggcggcc 336301 ccacgttccc cattggatga caatgacagg gacagaaggc gatttcccgt atgaaataag 336361 ctgctggcaa atataagaca agttcttgac acccatgtaa aaaacaaggg tttgaacgct 336421 tcgggccagc ccttcccagt caaggttcgg cgtgcctttt aatgatttat catgcgctgt 336481 aatcatggca aaagacgatg caaaatcccg atgcgtgacg gggatgcccg catatagcgg 336541 cgctgcaatt ccagaggtga ttcccggcac catttcatag cgaatgccgt gctcatgaag 336601 agcatctgct tcctcgccga ctctgccgaa tacgctcgga tctccgccct tcaagcgaac 336661 gacggttaac ccatttaatg ctttttcaac cagcagggcg ttaatttctt tttgtttcat 336721 aaaatggcgg tttggcagtt ttccgcaata aataaactgg cagtccggtg atgcaaattc 336781 gagcagcttc gggttggcga gccggtcata taaaatcaca tctgcttcct tgagcgcctg 336841 ttttcctttg atggtgagca ggcctgggtc gccgggtccg gctcccacga aatatacgat 336901 tccgttcttc atgatcatgt catccttccg tcactgtaaa aaatgaagga ccactagaaa 336961 agtgatccgg tcttttgatc aatatacgag ataaacatgt tctccttcga tcagcgtttc 337021 atatgttttg acgcatccgt ggtcaggttc ttggacgatt ccgtcttcta aggaaatttt 337081 ccagtcgtgc atcgggcaga aaacatattg accgctgacg atgccttctg ccaggacgcc 337141 gcccttatgc ggacagcggt tttcaatggc gcggatgctt ccgtctgaaa gcttgaaaac 337201 cgcgagctcc ttatcttcaa tatacactgt tttgcctaat tgttcaggca attcttcaat 337261 ttttccgata catacttttg ttacgtcttt gtttaccatg tccattcctc ctcaatgata 337321 gtttttgtca ttatgatgtg gtcacgacat tttcaaataa ttctttagag gtttgtttat 337381 cctctaaaaa gtctttccac ggatccttgt ggacagagag tgtttcattc attcggccgt 337441 tcagctcctg ccgcttttcc ggatcgttta acacggattg gacatgggat aaaccgacgc 337501 gctcaagcca tgcggacgta cgctccagat agtttgcggt ttccctgtaa tattgcaggt 337561 aagcgcccgc gtattctaag acttcttcat ttgttttcac cttcatcagc aaatcgccgg 337621 cacgcaaatg ggttccgccg tttccgccga cataaagctc ccagcctccg tcgatgccga 337681 caacgccaag gtccttaatg ccggattccg cacagtttcg cgggcaggca gacacggcca 337741 ttttgacttt gtgaggcgtg ttcagccctt cgaatttttt ctcaagcgca atgcccagtg 337801 ccatggagtc ttgtgtgccg aagcggcaga attgctcgcc tacacatgtt ttcactgtgc 337861 ggagcgtttt tccgtacgcg tagcccgatg gcatatcaag atcttcccat accttcggaa 337921 ggtcttcttt tttcacgccg ataagatcaa ttcgctggcc gcctgtcatt ttcacgagcg 337981 ggatctcata tttgtcaacg acatcggcga tcttgcgcaa atctgtggag ttggtcacgc 338041 cgccgtacat ccgaggaacg actgagtatg ttccgtcttt ttgaatattg gcgtgcattc 338101 gttcattaac aaagcgggat gtccggtcat cctcgtattt ggttggattg atcatgccta 338161 agtagtagtt cagagcgggt cggcatttag aacagccttc tggcgttttc cagccgagca 338221 cattcatgac ttctcttgta tgtgacagcc ctttggcttt gatttcttct acgacttcat 338281 ctctcgacaa tgtggtgcag ccgcaaatgg cttctttttg cgctgacgca tcaaagtctg 338341 atccgagcgt atgctggagg atttcttcta cgagcggctt acagcctccg catgagcggg 338401 atgcgccggt gcatgctttg atttcgtccg ttgacgagca gcccttttcc tgtatggctt 338461 gaataatcgc accttttgac acgccgttac agccgcagat gatttcatcg tcgctcatcg 338521 ctgcggttat gcttgtgcct gcttcctggc tgaggggctg taagattgat attttagagg 338581 tttcagagat atcggcttct ttttgaatca tagaaaacag gcgattgcct tcgctgctgt 338641 cgccgaataa aacagcaccg acaatttgat tgcctctcag gacaattttt ttatagatgc 338701 cgtcctgctc atcgaagact ttaatcgctt ttttctcctc tgattcgtta aagtcaccgg 338761 cagagaagac ctcgacgcct gataccttta actgtgtgga gagaacggag ccctcatacg 338821 gttttgtttc gatgccgcac atatgctttg ccagcacttt tgcctgttca tacagcggcg 338881 ccacaagccc gtaggcgatt cctcggtgct cggcacattc gccgaccgcg taaatgtgcg 338941 ggatttcagt ctgcatataa tcgttgacga tgatgccgcg gttaaccgga atgccgctct 339001 cggccccgag cgttgtattt gggcggatgc cgacagccat gacgactaaa tcagcttcaa 339061 tgcttgtgcc atccttgaat cggaggcctt cgacacggtc gtcaccgaca atttcttctg 339121 tttgcttttc aagtaaaaag gtcatacctt gtttttctaa ctcgttttgc agcaggcgtc 339181 ctgccgttgc atcaagctgg cgctccatca ggaatggggc aaggtggatg acggacacgt 339241 ccatgccgag attcagcagt ccgcgagctg cttccaaacc aagtagtcct ccgccgatga 339301 cggcagcttt tttatattgt tttgacgcgg cgagcattgt gtctgtatct tttatgtccc 339361 ggaaagctgt gacgcctttt ttgtctgcgc ccggaatcgg aaggataaaa gggaccgatc 339421 ctgtcgccag gatcaattca tcgtaaggct ggattctgtc tgcatctgtg atgactgttt 339481 tgttttccgt gtccactttg atgactgttt catttgtata caattgaatg ttgttttctt 339541 cgtaccagtc ccaatcgttt aacgtaatat ctttaatatc tgtatcgcct tgaagcactt 339601 ttgacaaaag gattcggttg taattgggat gcggttcggc accgaaaatt gtgatctgaa 339661 actcgtcttt agcaacactc agtatctctt caatggccct taccccggcc attccattac 339721 caacaagaac tagctgtttt tttcccatca gatgatccgc tccttatcaa atgttttttc 339781 cagcgtagca cagcaaaaag gaatatttaa gatacatgtt ataaaatgta acaaaatata 339841 cgaaaagttc taaaaatttt atgaaaaatt taaataggta tgattcggac ggcgcatacc 339901 ttaaaaccgg gcattttaca ggctggatct aaggcttccc cgattaaatc attcacattt 339961 tgagcgtctg cccaatggat gggaacaaaa acggtatctt ttctgatttg ttctgataat 340021 ttgctgcgga cggtgatgct tccccgcggc gattctattt ttaccagtac acggtcctcg 340081 atattgtagg tcgctgctgt ttgcggatgg atctccataa acgattcaaa atgtctcgcg 340141 gcaagggcgg cgctttttct tgtttggacg cctgttaagt agtgagacat gactctgcct 340201 gtcgttaaat aaagcggata atcggctgtc ggcttctctt ttggaacagg tggttcgttt 340261 ggaatcacac ttaatgccgc tttttgatcc ggatgagcaa atgattctgt aaacaagcgc 340321 ccagttccgg gatgatcaga ttccggacac ggccaatgaa tgccgccttc acgtctgagc 340381 ctgccgtatg agatgcctga ataatcggca atcccgcctc ggctcgcttc tctcaattca 340441 ttgaaaatat cctccgctga cgtataagaa aagtagcggc ccttgccgag agcggatgcg 340501 agatcacaaa tgatctgcca atcatgcttt gcttcgccgg ggcatggccg gcttgcttct 340561 cttaatgtca cgcgtccttc tacatttgtc atggtgcctt catcttctaa gtaagaggag 340621 gcaggtaaaa tcacatctgc gtatttcgca gtctcagaaa taaacaaatc gattgcgaca 340681 aagaatgtca gtcttcttaa agcctttttc acgagatttg catttggact ggaaacagca 340741 gggttggagc acatgaggaa cagtcctttg atgtcgccgt cattgatttt ttccatcatt 340801 tcataggctg agacaccttt tcgcgggagt tcatcctgat ggattcccca cactttcgca 340861 atatgcgccc ggtgttcttc gttttcgata gaacggtagc ctggaagctg atcggctttt 340921 tggccatgct ctctggcgcc ttgcccgttg ccttgtccgg tgatcgcccc gtagcccgag 340981 taaggtttgc cgatttttcc tgtgatcagc accatgttta agaagccttt cacagccgct 341041 gttccatcgg tttgctgttc aatcccgcgg gctgtaaaca gcatgccgga cgtttccttg 341101 gcaaacttca cagcagcttt tcttatatcc accagcgaga cactcgtctg ttcggcgatg 341161 tcattcaggt ccaacgagtc agtatgctgc ttcagctctt cgaatccatt tgttcgtgat 341221 tgaatgaaat cctcgtttat aagctgttcg tcaatgatga ttttgacgag accgttggca 341281 agggcggcgt ctgtgccggg tttgattttc agatgaagat cggcgatttt cgttgtcgct 341341 gtttcacgag gatcaatggc aatgaagtaa gctccgtttt ctttcgcttt ttcaaaatac 341401 ggcataatcg taggctggca ttccgcaata ttggtgccgg ccagaatgat cacacgggtg 341461 tgggggatgt ctgataaagg attcgttaag cctctgtccg cgccgaatgt ttggttggct 341521 gcggtggctg ctgcggacat acaaagtctc ccgttgtagt cgatgtattt tgtctgtaag 341581 cctactcgtg cgaacttccc taacaaatac gcctcttcat ttgtaatcga ggcgcttccg 341641 tataccgcca tggcgtcatg tccgtgttca gtttggatca ttgtcacttg gtctttgata 341701 tgattcagtg cttcttccca ggaaacaggc ataaactcgc cgtttttctt cagcagcggc 341761 cgggtgatgc gggaggagtt caaggcatgc tggtgagcat tcatgccctt gatgcatagc 341821 cgaccctgtg tcgtaggatt atcaatcccg atcgcagtgt actttttgcg cgtgacgatg 341881 gtttgttcca cgagctgcat tttgcactgc atgctgcaaa acgggcattg agtgtcatat 341941 gttttttctg attggacgtc ttgctgttta tcacggaaat atctaagcag tcgttcagtc 342001 aaaatgcctc atcctttctt atatgcgccc gtctctacag tcgggttttg aatcagtgac 342061 agatctgttt ggaggctttc cagcagctgt gcccttaggt cttcttcgaa tagcacttct 342121 ctgatatgaa cgatcccgag acggtctatc cactgatgaa caccttctaa gtaatgagcc 342181 gtttcccgat aatactggat cagtcctttg atcatgccgg cagtgctgtc ttcgttctca 342241 gtcacgcaaa acaaagctcc tgaacgggca tgagttcccc ggacgccgcc gatgtgaatg 342301 tcccagccag cttgtgtccg aattgcgccg acatcttgca gggcggcctc ggtgcagtct 342361 gtttcacatg ataagctgat agaaatggga gcgggtaagg gaagcatctc aagttgtctt 342421 tcgatttggg ctgccagctg ctgaatcgat cgattttgcc cgcatgtaca tgctttgatg 342481 ctttgcagcg cgtgtcggtg ttcattagtg taaacgggca ttttcaggtc ttttttcatg 342541 ttcgggagat ccgcaggctt gatcccggaa agcttcagcc tttggccgtg agtgatggat 342601 acgtcgggaa tgctgtatgc ctcaatgatg ttggcgatgg ttcttagctg ctccgcgttt 342661 gtccgcccgc cgtacatttg cggaatcagg atgcatgtct cttcagtggc tggctcaggc 342721 tggacaaacc cagggtacag catttccaga tagtattgaa tcgcaggaac acaagtactg 342781 catccgtttt ttgttttcca gtcaagctgg ttcatcactt ctgccggatt agtgaatggc 342841 ctgcgctgaa gctcagcgat gatgtcgtct tctgtaaaat cagtacagct gcaaaacgaa 342901 ggtgtgctgg cgggcttcgt atattcgctg ttggtcatgt atctcaaaag gtcttcaacg 342961 agcggtttgc atcctccgca ggacccagtg gctttggtgc agtgcttgac ttcctcaaca 343021 gttgttaagc tattcgtgtg caccgcgtct tcaatcgcgc ctttcgtcac tgtgttgcat 343081 tggcaaatcg tttcactgga aggcatggat tcaaataaag ggccgcttgt ctccggttcg 343141 atgatctgtt ttttggcaat ggagatgtct cgttgtttaa gcaggctgtc gagaagccgc 343201 tgcttgtcac gggtgtctcc gaataaaata acgccggcca gtttgtcatc tacaaaaagc 343261 gcttttttat aaacgcctgc ttgttcgtcg tagattttga tgctcgtcgt gcgttcatcc 343321 tcttggatct ttcctgctga ccacacatcg attccagcta tttttaacgc cgcagatggt 343381 gctgagcctt gatattcctc acatggaacg ccgcaaatat gactggcgag cgcttttccc 343441 tgctcataaa gcggagccac caatccgtac accgttccgt tatgctcagc gcattcacca 343501 acggcgtaga tattcggttc gcttgtctgc atgaagtcat tcacgatgat cccgcggttc 343561 actttgattc cagcggatac agccaattca atattcggtt tgacgccggc cgccatcaca 343621 atcaagtctg cttttaatga agagccatct ttaaaatgga ttcggtctgc cttcgtggcg 343681 ccggaaatgg agacggtgtc tttctccaaa agaaaggtta ggcctttttg ttccagctct 343741 gtttgcagca gccgcgccgc tgtttgatcg agctgttttt gcataatgcc ggcggagtgg 343801 tgaatgacgc tgacatccat accgagatgc tgtaaaccta ctgcagcttc cagtcctaat 343861 aagccggctc cgattaccgc agccttttga aagtgctggg ccatgttcat cagcgcttgg 343921 cagtcttcta ttgtccgaaa tccatagaca ccttttttgt ctgccccggg gatagggaga 343981 atatgagggg aggagcctgt tgccactatt aatttgtcat acgacagagt gcgtttccga 344041 tctgtgatga cctgctgctg atctgtatca atctgaataa ccgtttcgcc tgtgtaaagc 344101 gtgatcccgt gcttgtcgta ccaatccttg ctgttcagtg taatatcatc gagtgacgct 344161 tcaccctgca atacagagga taagagaatg cgattgtaat tgggatgcgg ctcgcttccg 344221 aaaatgacaa tctcaaacat gtggcgattc agctttaata cttcttcaat acagcggatt 344281 ccggccatgc cgtttcccgc taacactaat ctttgtttct tcatgtatca gacctccttt 344341 ggcgaagctc gtaagttttc tcctattaaa aattatgtca caatgcattg ttaacgcatt 344401 aaacgtgtca caaaaactta cacatgtctt ttccagaaaa taatggtcct atatccttga 344461 ttcagaaaat gtaaaataat gagggtctag aaaggggaat cttatgaagc tgtcggaact 344521 gaaaactagc ggtcatccac tcactttgct ctgttccttt ttatactttg atgtcagttt 344581 tatgatatgg gttatgcttg gggcgctggg tgtttatatt tctcaggatt ttggcctgtc 344641 tccttttgag aaagggcttg tcgtagctgt gccgatttta tctggatctg tgtttcgtat 344701 cattcttggt attttaacgg acagaatcgg accgaaaaaa acggcagtga tcgggatgct 344761 ggtgacgatg attccgctgc tttgggggac attcggcggc cgttccctga ctgagctgta 344821 tgccatcggg attctgcttg gcgtggcggg agcaagcttt gctgtagcgc tgcctatggc 344881 cagccgctgg tatccgcctc atttgcaggg acttgcgatg gggattgccg gagcggggaa 344941 cagcggcacg ttgtttgcaa ccctgtttgg ccctcgtctg gcagagcagt tcggctggca 345001 cattgtcatg ggaattgcgc taattccatt attgatcgtc tttattcttt ttgtatccat 345061 ggcaaaggat tcccctgcac agccgtctcc ccagccgctc aaaagctatc tgcatgtgtt 345121 tgggcaaaag gaaacatggt ttttctgcct gctgtacagc gtcacatttg gcggatttgt 345181 cgggctctca agctttttat ctattttctt tgttgatcaa taccagctgt caaaaattca 345241 cgcaggggac ttcgttacat tatgtgtggc ggcggggagc tttttccggc ctgtcggggg 345301 cttgatttca gatcgtgtcg gcggcacgaa agttctttct gtattgtttg tcatcgtggc 345361 actgtgtatg gccggagtca gtagcctgcc atctctctca atggttattg ttctattgtt 345421 tgtcggaatg atggggctcg gaatgggaaa cggcgcagta ttccagctcg tgccgcagcg 345481 cttccgcaaa gaaatcggca tggtgacggg aatcgtcggt gcggccggag gaatcggagg 345541 gtttttcttg ccgaacatct taggatctct caaacagatg acaggcacat atgctatcgg 345601 ttttatcacg ttttcctgta tcgcgctgct ggcgtttgca cttgtgcttg ccgcaggcta 345661 ttactggcgg aaaagctgga gcgcggaaag cagcccggcg gatgtttagg attttgacgg 345721 acacgcgttt gtgcgtgtct tttttatttt ctcttgattt tcaacagtga accgatcaaa 345781 ataaatagta attattacga tttgttagtg agaggagttt tctgaatgaa tcaacatacg 345841 ctgctcccga aaaaaacgga gcgtcttcaa tactttggat cggtcagtcc gatcaaaggc 345901 gagaaaccag tggaaaaaga gaaaatgaag gacctgcaaa atatcaggaa ggattatttt 345961 tttgacattc agcatgtagg tgtagctaat gtgtcccatc cagtcacaat cacttctgcc 346021 atgatgcctg ccgagcaaac aacggctgcg aactttacaa tgacttgtaa tttgccgaga 346081 aatcagaagg ggattaacat gagccggtta acagagctgc tgcaagtcta tcatcaaaat 346141 ggctggattc tctcattttc ctctcttcag caatttacga aagagcttgc agaaaacatg 346201 gacacatcat ctgccacagt tgaagtgagg tttccgtggt ttttcgaacg gaaaagcccg 346261 aagcttgaga aagcgggttt gatgcatgct gatatattca tgtctgtcac ctatcgcaaa 346321 gatcagccgt ttaaacagcg tgccggcatc tcagcaaaag taacgactct gtgcccttgc 346381 tccaaggaaa tcagcgaata cagtgcccat aatcagaggg gaacggtcag catttgggcg 346441 gatattcacc cggccgcatc gctgccaagt gatgttaaag ctgatttgct tcacgccgca 346501 gaatcaaatg cttctgcgag actgcatccg gtattgaagc ggcctgatga aaaagccgtg 346561 acagaaacgg cctatgaaaa cccgagattt gttgaggatc tcgcccggct gattgctgca 346621 gatttgtttg agcttgaatg ggtgtcagcc tttgagattg aatgccgaaa tgaagaatcg 346681 atccatcttc acgatgccta tgcgaagctg tgtttttcga aggaagtgga taaaatatga 346741 aactctcatt attcattatt gcagttctta tgccagtcat cctgctgtca gcctgctccg 346801 atcatgcaga agaacacgca agtatcaata caaagaaaac ggtcgaaaac ataacggacg 346861 ttcgaaaaac agcaaaaaca agcattgatt ggacaaagcc ttcgggcgga gaatacccgg 346921 atattaaaca gaagcatgtc tggattgatg tgaatgtgaa ggagcagaag gcttacatca 346981 aggaaggaag caacaccatc tatacaatga tgatttcttc tggtcttgat caaacaaaag 347041 atgatgctac gccaaagggc accttttatg tagagcctga acggggagaa tggtttttct 347101 ccgaaggata ccaggaaggc gcagaatact gggtatcatg gaaaaatcac ggtgaatttt 347161 tatttcatag tgtgccaatg actaaggatc aaaaagtcat caaaacggaa gcagaaaaac 347221 taggaacgaa agcatctcac ggatgtatca ggctgaccat tccagatgcg aaatgggtat 347281 atgaaaatat ccctgaacat acaaaagtgg tgatcagctg aattgaaaac cgttgacaaa 347341 aaggaaaaaa gaccatacaa tttaaatcgt aacaattacg ttttatgata aatggcttat 347401 cattgtctgt gcatctgtga aaagcggaaa ggcatcgatt aaggatcttg ctgtcggcaa 347461 aggcaaggat ttgcgatggg gaaaaggatt aaacgcggtt ggagtcttta ctgatttaga 347521 aatcgggcgg cagcgagaaa tgagcgcgaa aagctgctct acaccattgt acatacggcg 347581 aagtattcaa tttaaatcgt aatcattcta ttttaatgga ggcactatta tgaaaaaaat 347641 tccggttacc gtactgagcg gttatctcgg tgcgggaaaa acaacattgc tgaacagcat 347701 tttgcaaaat cgcgaaggct tgaaaatagc ggttatcgta aacgatatga gcgaggtgaa 347761 cattgacgcg ggcttggtta agcaggaagg tggcctttcc agaacagatg aaaagcttgt 347821 ggaaatgtca aatggctgca tttgctgcac gcttcgcgaa gacttattaa ttgaagttga 347881 gaagctggca aaagacggac ggtttgatta tatcgtcatc gaatcgacag gaatcagcga 347941 accgatcccg gtggcccaga ctttctctta tatcgatgaa gagatgggaa tcgatcttac 348001 aaaattctgt cagctggata cgatggtgac ggttgttgat gccaaccgtt tttggcatga 348061 ttatcagtca ggcgaaagcc ttctggaccg caaagaagca ttgggggaaa aggatgaaag 348121 agaaatcgcc gacctcttga tcgatcaaat tgagttttgc gatgtactga tcttaaataa 348181 atgtgatttg gtcagcgagc aagagctcga acagcttgaa aacgttcttc gtaaactgca 348241 gccaagagcc aggttcattc gttccgtcaa aggaaatgta aaaccgcagg agattttgca 348301 tacagggtta tttaacttcg aggaagcgag cggatcggcc ggctggattc aagagctgac 348361 ggcaggccat gcggaacaca ccccggaaac agaagaatac ggtatctctt catttgtata 348421 taagagacgt ttgccgtttc attctacacg attttaccgt tggttggatc aaatgccaaa 348481 gaacgtggta cgtgccaaag gaatcgtctg gtgcgcatct cataacaacc tcgctttgct 348541 gatgtcgcaa gcaggtccgt cggttacgat tgagcctgta tcttattggg tggcggcgtt 348601 gccgaagctt gagcaggagc aagtcaaaca gcaggagccg gaaatcctgg aggagtggga 348661 cccggagttc ggcgaccgcc taacgcagct agtttttatc ggaactgacc tggatgaaga 348721 aacgatcacg aaagagcttg atcaatgcct gttgactgag tatgaatttg attccgactg 348781 gtcgctgttt gaggacccgt ttaaatggaa gctgaatcaa tagaaaaaaa gccgtcccat 348841 ggggaacggc tttttttaat gaaacgtttg tttaaacata atgagcgtat tttttctcaa 348901 ggatattctg aaagaccgcg gcaatggagc agatggccca ataaatgaga gcggtcagaa 348961 tatacatggt catataatca aactctctgc ccccgatgat tttcgcatgc tggagcaatt 349021 ccggcactgt aatcatcgca gcgagagagg acgccttgat caagtcgagc aatacattgg 349081 caagcggagg cagcgcaata cgtatcgatt gcggcaaaat gatgcccctc atcgtctgcc 349141 aataggaaag acccagcgag gatgcggctt cccactgtcc tttttcgacg gatgaaatgg 349201 ctgaacggtt aatttccgca atgtaggcgg cgctgtttag gctaaagccg attaaagcag 349261 ccgtgacagc ggaaaattca atgccgatat aaggaaaccc gaaataaagg ataaacaaaa 349321 tcaccaaaat cggaacgcct cgcataaatg agatatagag cttcgccggc catcttaaca 349381 aagcaagttt agacattctg gcgagtgata tgaacaggcc gatcacagtt cccgcaaaca 349441 tgcttacaaa agagatgagc agtgtataac caatgccttt tatgacataa gggaacgatt 349501 caatggccag cttcgtgttg aaaatatatt cccactgaat gctattgatc atggcgtccg 349561 attacaaatc aacgtcctga acgtcggcat caattttttt tgatacatct gctttattga 349621 agaattgttt cgacagttta gtcaaagagc catccttgct catctctttc aatgcttcgt 349681 tcatcttttt ctgaagtgcc gcattgcttt ttttcatgac aagggcctgt ttgttcggca 349741 tgtacttgat gtcaggatga attgtaatgt tgagatccgg gaatgccgcg agcgcaagtg 349801 tctgcaggta atagtcgttt aaaatgacgt cagtgcgtcc gttggcaaca tcttttaaat 349861 attgctcatt cgtcgcatta tcataaatca cttctttggc gccgtatttt ctcgcgacct 349921 ccatgtagac ggttgtagcc gcgccagccg ctttcttccc ttttaaatcc ttgagcgttt 349981 taatccctga taaatcgtct tttcggacaa ttgccgtgcc gtatgaatat ttatatggag 350041 tggaaaatgc gaacttctcc tcacggtcct tcgtcacatc gatgtcattc gcggctgcgt 350101 caacctgtcc gctgttcacc gctgtcagca tcccgtcaat gcccatctcc ttgaactcaa 350161 ccttcagccc caagcgtttt gccgcttcac gaacaacttc aacctcgtag cccgtcagct 350221 tatcagagcc agagtcagta tcgtgataag aagtgggata gagcgtacct gatgtagcga 350281 ctacgatttt ccctttatcc ttaatctgct cccagcctgt atccttggaa tcggcttcat 350341 ttttgccgga acaggctgcc aatataagaa agaaagccat tgtgaaactg aatataacgg 350401 ctttggaatg catgaatgat ttcacctata gttcccccaa tctgttaatc aactaaaaag 350461 atagcattga acataagggg ttgcaatatg ttgatcgcgt tttcaaaaag ttcgaattgt 350521 gtatacaaaa agcatgggtg ggtgtttaaa agcgtctatg aagggaagag gtgatgaaaa 350581 aaggaattgt ccaaggatga atgccagacg taccaaggaa acgcatgtga aagtgaagga 350641 tgcagcagac ccgtcactca tctatgccaa taccggaaga aatggtcaag aggcatgaaa 350701 ccgatcttca gaataaattt aagtcttgct gatgccccta aggcatatga tatattcgat 350761 gagaaagaaa atggaaacat ttaaaccata atggggagtc aaatgaatat ttacaaacca 350821 gccggatttt ggatcagact tggagctgca ttgttagact acattatagt ctccgtgccg 350881 cttttgctga tctattggct gattacagga aaagacccaa acgacagcat gttcatcagt 350941 ttggttgttc tgctgtattc tattttgctg ccgatgtttt ggcgcggtta tcttatcgga 351001 aaaaggatct gcggaatcag aatcgtaaaa aaagacggat cacaggtcag tctgttaaca 351061 atgtttttac gggttattgt agccggcctg gtttactgta taaccttcgg actcggcttg 351121 atcgccagcc tgattctgat tgccgtacga gaagacaaac ggaccctgca tgatttaatc 351181 gcgggaacat atgtcactta tgcgacacca ggtgaagagg aacttaatgc tgacgaagag 351241 attagaaaga gcgaataatg gttcgctctt tttattttta tgcataaaaa atacaaggca 351301 gcaaaacata tgaaaaatag gattggagga ataaaatgga tgaaacgaat aaccatcaac 351361 attatcacaa tgttcattgc agcggctgtc atttctctga ccggtacagc tgaggccgct 351421 gaaaaacagc agcagtctcc cgcaaatgtt acactgacag atcagcaaaa gaaagagatt 351481 gaacaactgg aagcagagat tcttaaaaag cgcaaagacg tgatctcaaa gtatgtacaa 351541 tacggtatcc tgcctaaaga aagaggagaa cacatcaaaa atcacttgga caaacacttt 351601 gaaatgatga aacaaaacgg ctttgttcca aagcaccatc ctcatccgca taaatttgaa 351661 aaaagacatt aagattttaa gcatccaatg ggaattgggt gcttttgcgt tatttacagg 351721 taggcaatat tagctgagct gttccgcgac taacatcgag ttgatatgaa acgcgtttca 351781 tagcctatga taggtttatc aaataattca ggagtgataa acactatgat ccaccagcat 351841 ccagaatctt ttccgaaaca ttttttgtgg ggctctgctt ctgcagcgta ccagattgaa 351901 ggcgcttgga atgaagatgg caaaggccct tctgtttggg atgtgtttac gaaaataccg 351961 ggcaaaacgt ttaaaggaac caatggcgag attgcggttg accattatca ccgatttaaa 352021 gaagatgtcg ctctgatggc tgagatgggg ttaaaagcat atcgattttc cgtcagctgg 352081 ccacgggttt ttccaaaagg aaaaggagag atcaatgaag caggtctagc gttttacgat 352141 agtctgattg atgaattgct ttctcatcac atcgagccgg ttctgacttt atatcactgg 352201 gatttgcctc aagcgcttat ggacgaatac ggcgggtttg aatccagaaa catcatagag 352261 gattttaatc actactgtat tactctttat aaacgttttg gagacagggt gaaatattgg 352321 gttacgttaa acgaacagaa ctacaatttt aatcacggat ttattacagc catgcatccg 352381 cctggagtga aagacagaaa acgattttac gaagcaaacc atattgcgtt tctggctaat 352441 gcaaaagcca tcgaatcatt tagagaatat gtgcctgaag gcaaaatagg tcctagcttt 352501 gcttattctc cggcttaccc tttatcaagt catccagagg atatactggc atttgaaaac 352561 gccgaagaat ttacgaacaa ttggtggctt gacatgtatt gctggggaac ctacccgcaa 352621 attccattcc gctgcttgga aaaacaggga tgggcgccga caattgaagc aggagatatg 352681 gacctgctcg ccaaagggaa gcctgatttt gtaggtgtca attattatca gacgatcacc 352741 tatgaacgaa atccgcttga tggtgtgtca gaagggaaaa tgaatacgac aggccaaaag 352801 ggaaccaatc aggagacggg gatacccgga gtgttcaaaa cgaaaaaaaa tccgcatctg 352861 acaacgagca actgggattg gacaattgac ccaattgggc tgcgtatcgg tcttcgccga 352921 attacaagcc gctatcagct tccagtgttt ataacagaga acggtttggg tgaatttgat 352981 aaagttgagg acggcactgt acaggatgat tatcgaattg attatttgcg ttcgcatctt 353041 gagcaatgca gacaagccat cagtgacggt gtcgatttaa tcggctattg cagctggtcg 353101 tttactgatc tgttaagctg gctgaacggc taccaaaaaa gatacggatt tgtatatgtc 353161 aatcgtgatg aagaaagcac atccgattta aaacgcttga agaaaaaaag cttttattgg 353221 tatcaagatg tcatcaagac aaacggagaa agtttataaa gagtccctga gagttattct 353281 ctcaggggtt tttcattaca cagaaacagc atcaataata taagtgtcgg cgtgcaaatc 353341 tgacatttca gccggcacag tccagcatgt caattgatag tctcctttag gcagatcaaa 353401 ggacagtctt ttagacatga tgctttcaat atgaattccg ttttctgtga catgaaaagg 353461 aacagtcact tttttttcgt aggagtttac tgtttctgaa ctgttcaggc gaaaaagaat 353521 aaaggccttt gtatttcgct gtgcctcaaa ggaaatggct ccgtctgccg cagcatatcc 353581 tttttcaatc gcttcgtcag tccaatccat tacaggaggt gtagaatcct tttgaaatac 353641 agtaaattga tgatatgaaa tcgaaagttc ttgcggcttc catgatttga tcaatgtgct 353701 gttcctcctc tatgtactgt ttactgaatt gtgaataaaa cctttgtgcc gtctgggtaa 353761 tcggtaagcc gatgcccgac ccaagagcct gctccgcggt tgtcagcggg agaaatgtat 353821 tctacagaag ctccctcacc gccttctttg cacatggcca ttggccattc atctctgtca 353881 tacccctttt tggaaggtac gtcctttaat gattgctcgc ggcgttcttc agctccgtct 353941 ctgtcaatag tgcacacctc tgagtgcccc tcatttatcg catccttaat atgcttggca 354001 gtttcgggat accggtcaga tgggaaggcc attgtttcat catattcttt cgtttgagac 354061 gttttttgat cagctgagaa aaagtctcct tttatcaggc cgacagctgc agctgctatg 354121 atgacgatga cgagaagtat cgtttttatg atgtccgtcg tgatgttcac ctcccgcttt 354181 taaaactgac acaagagtaa tccagaaagc atttggtgta aaggtttaaa ttttatgttt 354241 tacgatcagt ttattgcaga aatcgtaatt ttagcagatc gaaatatttg ttttcagcaa 354301 aatacgattg ccaatttaca ataatgatag taagtcatca gccgttttcg gcttgattaa 354361 tcattttaaa ttggcttatg ataccggtaa gctcctcagc taattgagaa agtgtttcag 354421 aagctgcggt aatctcctcc attgcagcaa attgctcctc tgttaatgca gccgcttgcc 354481 gggtattttt agtagattct ttaatgtcgg ccgtattggc tgcaaaggaa tcatttattt 354541 gatgtgcact ggctgaaatg tttgttacag atgctgataa atcactaatc tcggcgctga 354601 tttcacctgt tgcagctgca atttccttaa atgcatctct ggtgcgctgg atcatggtga 354661 ctccttctgc agcttctgtt ttcacatgct caacagatct tgcagaccgg ttcatatcct 354721 tttgtatttc tatgatcagt tttgaaatct gccccgcaga ctgttgagac tcttctgcta 354781 atttccgtac ttcatcagca acaacagcaa agccttttcc ttgttcaccg gctctggcag 354841 cttcaatcgc tgcattcagc gcaagcaggt ttgtctgatc agcaatttgg gtgatgaccg 354901 ataaaatttg ctcaatttgt ttagagcggc cgtctaactg gtgtatgatt tctccgcttt 354961 tctgaattga ctggtgaatc gcatccattt gcgcctgtac atttgcaatt tccttttgtc 355021 caatgtctgc ttttgattga gcgagctgcc ctttgtcagc gatagcggca gtatttgcag 355081 aaatatcccg gatgtctgct gaagcttgtt ttaatgagct ttcactattt tcaattcggg 355141 tgatctgatc ttgggctcca tttgcaatct gctgtacagc ttctgtgatt ttttctgaag 355201 cttgatttgt ttcctctgct ccggctgaga gctgctgaga ggctgacgca agctgaaggg 355261 ctgattgttg tacggtttgt atggtatcgt tcagcttcat tctcatctta ttataataga 355321 cgcttagttc tgaaagctcg tcaccggttt tgtctgacac ctctattgtc atatctccgt 355381 ttccggcact ttcaaaggcg ctttttaaag cgttcagccg cttgttgatt tttctggtga 355441 aaaccaagac aaggatgact gataccataa tgacgataac aagaacgata gcgaattgag 355501 tgaaaagtga ttgtgtaagt gatgctaaaa tactttgatt agctccggta tacagcatgc 355561 cgatgatgtt cccattttga tcttttaacg gcatgtatgc agtctgataa gaagaacctg 355621 ctacatctgc ttgtccgtaa aaacgctttc ctttctttaa aacagcggca ataacttcag 355681 aagaagcctg ggtgccgacg gctctttcgc catttttcat gacattggtt gcaacacgag 355741 tatcgccttg gaaaatggta atggtatcac ctgtcttttc accaagcaga tcaacaatat 355801 cttcatttcc attgatttgt gtttgccctt tatagagctt attgtttttc acctgccagt 355861 cgcctgacat gacatcatca atataagtgc tgcttaaagc gagatcacct ttcgcttttt 355921 cagttgccat ttgtttcatg ctttctgtaa tttccttaag catcacagtg ccaactgatg 355981 ccgaaaacaa aagaatcacc acgaaaacga ggcaaagaat tttagttcct agcttcatct 356041 taaatcgttt tatcaacata attcctccct ttacgatttg caggtcatat tacttatcgg 356101 gtttttgggt ttaaagtttt attttagaaa aaataaaacc ggcctgatct tcaggccggt 356161 tgtgtgatgc tattcaaggt ttgcgtggtg agtgaacata gtttcagaat cgagaccttt 356221 tttctccatg agttttaaaa tcactgcatc atagaagagc agcaaagttt gttcaaataa 356281 tgatcccatt ggctgaatgg ttttatagct tccgttagac tggtctttag gggaaccagg 356341 cattctgatg atgaggtccg cttgttttcc gatgcttgat tccggattga tggttaaagc 356401 ggcaacaatt ccgtgtaagc tttttgcttt tgctgcggta tgaatcaagc tctttgtctc 356461 gcctgatcct gagccgataa taactagatc tccttcggcg agcggcggag tgagaatctc 356521 acctactata tgggcgttga agcccatgtg catcagtctc atcgcgaagg attttgccat 356581 caggccagac cgccccgcac ccgcggtgaa aatttggtgg gatgaaagaa tgtgatcggc 356641 aagctggtca gcttcttcat tagaaatata agctgctgaa ttgtgtaact cattgagaat 356701 ttccgctacg tattcagtcg ttttcatcgg agttatcctt ggacaatcag ctgcttcatt 356761 tttgaagctg tttccgcctt atcagctgcg cttgtaattc cgcccccgac aatgacaagg 356821 tcaggctttt gctggatcac ttctggcagt gtatcaagtt tgatgccgcc cgcgattgcg 356881 gtttttgcgt tttttacggt atttttgatt gtcgttaatt cttcgaaaga gtttttgccc 356941 tctgcttgaa gatcatagcc agtgtggacg cagatgtagt caacaccgag tgcgtcaatt 357001 tctttcgcac gggattcgat atctttcacg ttaatcatgt ccactaagat tttcttcttt 357061 tgttttttgg cttcttctac tgcgccttta atcgttgcat cgtctgtagc ccctaaaacg 357121 gtgatgatgt cagcgcctgc ttccgacgct ttcataattt cgtagcctcc ggcatccatg 357181 attttcaggt ctgcaagaac cttcaattga ggaaatgctt cttttatttc tttaacggct 357241 cttaggcctt cattgatgac gaccggtgtt ccgatttcaa ctacgtcgat gtattgttct 357301 acctctttga caagctcaat ggcttccggg atgttgacga ggtctaatgc aagctgtaat 357361 tccattgttg atccactccc tttttcgaat tattgttcat tctataggtt ccttcttttg 357421 ttgagaagta ggcactttga agtcaacaag ttacttggag gatactgtga ggagagacaa 357481 tcagatttct ttcgcttgat tttatgagtg agtataatga aaaaagagtc tgcaaaaaag 357541 taagtaagtg atgatacgta tctaacatac aaaaaggtta ctaagggggg ggattctatt 357601 gagccggatg gacgacaaaa ggtttaattg tgagaaggaa ttaacgcttg cagtgattgg 357661 cggtaaatgg aaaatgctca ttttatggca tttaggaaaa gaaggcacaa aacggttcaa 357721 tgaattaaaa acattgattc ctgatattac gcagaagatc ctcgtgaatc agctgagaga 357781 gcttgagcag gatatgattg ttcacaggga agtgtatcca gttgtcccgc cgaaggttga 357841 atattctctg accccgcacg gagaaagcct catgcctatt cttgaagcca tgtatgagtg 357901 ggggaaaggc tatatggaat tgattgatat cgacaaaaat gtcatgaaag aatcgttgta 357961 agacgctctt cgcaagggtg tctttttttg cctttttttc ggtttttgcg cggtacacat 358021 agtcatgtaa agattgtaaa ttgcattcag caataaaaaa agattgaacg cagcagtttg 358081 gtttaaaaat ttttattttt ctgtaaataa tgtttagtgg aaatgattgc ggcatcccgc 358141 aaaaaatatt gctgtaaata aactggaatc tttcggcatc ccgcatgaaa cttttcaccc 358201 atttttcggt gataaaaaca tttttttcat ttaaactgaa cggtagaaag ataaaaaata 358261 ttgaaaacaa tgaataaata gccaaaattg gtttcttatt agggtggggt cttgcggtct 358321 ttatccgctt atgttaaacg ccgcaatgct gactgacggc agcctgcttt aatagcggcc 358381 atctgttttt tgattggaag cactgctttt taagtgtagt actttgggct atttcggctg 358441 ttagttcata agaattaaaa gctgatatgg ataagaaaga gaaaatgcgt tgcacatgtt 358501 cactgcttat aaagattagg ggaggtatga caatatggaa ataacttttt accctttaac 358561 ggatgcacaa aaacgaattt ggtacacaga aaaattttat cctcacacga gcatttcaaa 358621 tcttgcgggg attggtaagc tggtttcagc tgatgcgatt gattatgtgc ttgttgagca 358681 ggcgattcaa gagtttattc gcagaaatga cgccatgcgc cttcggttgc ggctagatga 358741 aaacggggag cctgttcaat atattagcga gtatcggcct gttgatataa aacatactga 358801 cactactgaa gatccgaatg cgatagagtt tatttcacaa tggagccggg aggaaacgaa 358861 gaaacctttg ccgctatacg attgtgattt gttccgtttt tccttgttca ccataaagga 358921 aaatgaagtg tggttttacg caaatgttca tcacgtgatt tctgatggta tctccatgaa 358981 tattctcggg aatgcgatca tgcacattta tttagaatta gccagcggct cagagacaaa 359041 agaaggaatc tcgcattcat ttatcgatca tgttttatct gaacaggaat atgctcaatc 359101 gaagcggttt gaaaaggaca aggcgttttg gaacaaacaa tttgaatcgg tgcctgaact 359161 tgtttccttg aaacggaatg catccgcagg gggaagttta gatgctgaga ggttctctaa 359221 agatgtgcct gaagcgcttc atcagcagat tctgtcgttt tgtgaggcga ataaagtcag 359281 tgttctttcg gtatttcaat cgctgctcgc cgcctatttg tacagggtca gcggccagaa 359341 tgatgttgtg acgggaacat ttatgggcaa ccggacaaat gcgaaagaga agcagatgct 359401 tggcatgttt gtttctacgg ttccgcttcg gacaaacatt gacggcgggc aggcgttttc 359461 agaatttgtc aaagaccgga tgaaggatct gatgaagaca cttcgccacc aaaagtatcc 359521 gtataatctc ctaatcaacg atttgcgtga aacaaagagc tctctgacca agctgttcac 359581 ggtttctctt gaatatcaag tgatgcagtg gcagaaagaa gaggatcttg cctttttgac 359641 tgagccgatt ttcagcggca gcggattaaa tgatgtctca attcatgtaa aggatcgatg 359701 ggatactggg aaactcacca tagattttga ttaccgcact gatttatttt cacgtgaaga 359761 aatcaacatg atttgtgagc gcatgattac catgctggag aacgcgttaa cgcatccaga 359821 acatacaatt gatgaattaa cactgatttc tgatgcggag aaagagaagc tgcttgcgag 359881 ggccggcggt aaatctgtga gctaccgtaa ggacatgacg ataccagagc tgttccaaga 359941 aaaggctgaa ctgctttctg atcatccagc ggttgtattt gaagatcgca cattgtccta 360001 tcgaacgtta catgagcaat ctgcacgcat cgccaatgtg ctgaaacaga aaggggttgg 360061 cccggacagt cctgtcgcgg ttttgattga acgctctgaa cggatgatta cagctatcat 360121 gggaatttta aaagccggcg gagcctatgt gccgattgat ccgggttttc ctgctgagcg 360181 cattcaatat attttggagg actgcggggc ggatttcatc ctgactgaat cgaaggttgc 360241 ggcgcctgaa gccgatgctg agctgattga cttagatcag gcgattgagg aaggtgcaga 360301 agaaagcctg aatgcagatg tgaacgctcg gaaccttgcc tacattattt acacatcggg 360361 aacaaccgga cgcccgaaag gcgttatgat cgagcatcgc caggttcatc atttggttga 360421 atctctgcag cagacgattt atcaaagcgg cagccaaacc ctgcggatgg cattgcttgc 360481 gccgttccac tttgatgcgt cagtgaagca gatcttcgcg tcgcttcttt tgggccaaac 360541 cctttatatc gtaccgaaga aaacagtgac gaacggggcc gcccttactg catattatcg 360601 gaagaacagc attgaggcga cggacggaac accggctcat ttgcaaatgc tggcagcagc 360661 aggcgatttt gaaggcctaa aactgaagca catgctgatc ggaggagaag gcctgtcatc 360721 tgttgttgcg gacaagctgc tgaagctgtt taaagaagcc ggcacagcgc cgcgtttgac 360781 taatgtgtac gggccgactg aaacgtgcgt tgacgcgtct gttcatccgg ttatccctga 360841 gaatgcagtt caatcagcgt atgtgccgat cgggaaagcg ctggggaata accgcttata 360901 tattttggat caaaaaggcc ggctgcagcc tgaaggcgtg gcgggtgagc tttatatcgc 360961 gggagacggt gtgggccgag gctatttaca tttgcctgaa ttaacggaag agaagttttt 361021 acaagatcca ttcgtgccgg gcgatcgcat gtaccggacc ggggacgtgg tgcgctggct 361081 tccagatgga acaatcgaat atttaggcag agaggatgac caggtcaaag tccgcggata 361141 ccggattgag cttggggaaa ttgaagccgt gattcagcag gcgccagacg ttgcaaaagc 361201 cgttgttttg gcacgccctg acgaacaggg aaatcttgag gtttgcgcat atgttgtgca 361261 gaagcctgga agcgaatttg cgccagccgg tttgagggag catgcggcca gacagcttcc 361321 tgactatatg gtgccggctt actttacaga agtgacagaa attccgctta caccaagcgg 361381 caaagtcgac cgccgcaagc tgtttgcact agaggtgaag gctgtcagcg gcactgccta 361441 tacagcgccg cgaaatgaga ctgaaaaagc aatcgcagcc atttggcagg acgtgctgaa 361501 cgttgagaag gcggggatct ttgacaattt ctttgaaact ggcggacatt cattaaaagc 361561 catgaccctt ttaacaaaga ttcataagga aacaggcatt gagattccgc ttcaattttt 361621 gtttgagcat ccgacgatta cggctcttgc agaggaagct gatcacagag aaagcaaagc 361681 ttttgcggtg attgaacctg ctgaaaaaca ggagcattac ccgctttcat tggcacagca 361741 gcgaacatat atcgtcagcc agttcgagga tgcgggagtc ggctataaca tgccagcagc 361801 agcaattctg gaagggcctt tagatattca aaagctggag cgcgcatttc agggattaat 361861 ccgacgccac gagtcattga gaacatcatt tgttcttgaa aacagcacgc cgagacagaa 361921 aattcacgat agcgttgatt tcaacatcga aatgattgaa agaggcggcc gctcagatga 361981 ggcaattatg gcttcattcg ttcggacatt tgatttggcg aaagctccgc tgttcagaat 362041 cggtttgctg gggcttgaag agaaccgtca tatgctgctg tttgacatgc accatttgat 362101 ttctgacggt gtatccattg gcattatgct ggaggagtta gcacgcattt ataaaggcga 362161 acagcttcct gatcttcgtc tccagtataa ggactacgct gtatggcaaa gcagacaggc 362221 tgctgaaggg tacaagaagg accaggctta ttggaaggaa gtctttgcag gcgagctccc 362281 ggtgcttcag cttctgtccg attacccaag accacctgtt caaagctttg aaggggatcg 362341 ggtgtcaatc aagctggatg cgggggtaaa ggatcgcctc aatcgtttgg ctgaacaaaa 362401 cggcgccact ttatatatgg tgatgctttc cgcttactat acgcttttgt caaagtatac 362461 ggggcaggat gacatcattg tcgggacacc gtcagcgggc agaaatcact ccgatacaga 362521 gggcattatc gggatgttcg tcaatacgct tgcgattcgc agtgaggtga agcagaatga 362581 gacgtttacc caattgatct cgcgtgtccg caaacgggtg ctggatgcct tttctcatca 362641 ggactatccg tttgagtggc ttgttgaaga tttgaacatc ccgcgtgatg ttagcaggca 362701 tccgctgttt gacacgatgt tcagccttca aaacgcgaca gagggcattc cggctgtcgg 362761 cgatctttcc ttgtctgttc aagagaccaa tttcaagatt gccaaatttg atttgacggt 362821 gcaggcgaga gaaaccgatg aaggcattga gattgatgtg gattacagca caaagctgtt 362881 taaacaaagc acggcagaca ggctgcttac gcattttgcg cgtttgcttg aagatgctgc 362941 ggctgatcca gagaagccga tttctgagta taagcttctt tctgaagagg aggctgcttc 363001 gcaaattcag cagtttaacc cgggcagaac accttatccg aaagataaaa caattgttca 363061 gctgtttgag gagcaagcgg cgaatacgcc agaccacact gcgcttcaat atgaaggcga 363121 atcactcact tatcgtgaac tgaatgaacg ggccaatcgt ttagcccgcg gcattctttc 363181 tcttggagct ggcgaaggca gaactgcggc tgtcttatgc gagcggtcaa tggatatgat 363241 tgtgtcgatc ttggcagtat taaaatcagg ttcggcttat gttccgatcg atccggaaca 363301 tccgattcag cggatgcagc atttcttccg tgacagcgga gcaaaggtgc ttctcactca 363361 gaggaaatta aaggctttgg cggaagaagc ggaatttaag ggcgttatcg tgctagccga 363421 tgaggaagaa agctatcatg ccgatgcgcg aaatctcgca ctgcctcttg attctgcagc 363481 aatggccaac ctgacgtata cttccggaac gactggaaca cctaagggga atatcgtgac 363541 acatgccaat attctccgca cggtgaagga aacgaattat ctcagcatta cagaacagga 363601 tacgattctc ggtctttcca attacgtgtt tgacgcgttt atgttcgata tgttcggctc 363661 tttgttaaac ggagccaagc tggtgctgat accgaaggaa accgttttgg acatggctcg 363721 cctgtcccgc gtcattgaac gggagaacat cagcattctc atgattacaa ccgctttgtt 363781 ccacttgctt gtggacttga atccggcatg cttgtcaacg cttcgcaaga ttatgtttgg 363841 cggggaacgg gcttcggttg agcatgtcag aaaagctttg caaacggttg gaaagggcaa 363901 gctccttcat atgtatggac cgtctgaaag cacggttttc gcgacgtatc atccggttga 363961 tgaattggag gagcacacgc tgtctgttcc gattggaaaa ccggtcagca atacggaagt 364021 atacattctt gaccgtacgg gacacgtgca gcctgccggg attgccggag agctttgcgt 364081 cagcggcgaa ggactcgtga aaggctatta caaccgtcca gaactgactg aggagaaatt 364141 tgttccccat ccgtttacat ccggcgaacg catgtataaa acgggagacc ttgcgagatg 364201 gctgccgaat ggcgacatcg aatttatcgg gcgaatcgac catcaggtga agattcgcgg 364261 acagcgcatc gagcttggag aaatcgaaca tcagctgcaa acccatgatc gtgttcagga 364321 aagtgttgtg cttgccgttg atcaaggagc gggagataaa ctgttgtgtg cttactatgt 364381 cggagaagga gacatctcat cacaagagat gagagagcat gctgcgaagg acttgccggc 364441 atatatggtt cctgcggtgt ttatccaaat ggacgagctg ccgctgacag ggaacggaaa 364501 aattgaccgg agagcgctgc cgattcctga tgccaacgtt tcaagaggtg tttcatatgt 364561 tgcgccacgc aatggaacgg aacaaaaagt cgcggacatt tgggcacagg tacttcaggc 364621 agaacaagtc ggcgcttatg accacttctt tgacattggc ggacattcat tagcaggcat 364681 gaagatgctt gccttggttc atcaggaact gggcgttgag ctgtcactca aggatctctt 364741 ccagtcaccg acggttgagg gcttggcaca ggtgattgcc tctgctgaaa aagggacagc 364801 cgcaagtatc agcccggcag agaaacaaga tacgtatcct gtttcttcac cgcaaaaacg 364861 gatgtacgtg cttcagcagc ttgaggatgc gcaaacgagc tataacatgc cggcggttct 364921 gcgcctgaca ggtgagcttg atgttgaaag gcttaacagc gtcatgcagc agttaatgca 364981 gcgtcatgaa gccttgagaa ccacgtttga aataaaagat ggagaaacgg tgcagcggat 365041 ctgggaagag gctgagtgcg agatagccta tttcgaagcc ccggaagaag agacagagcg 365101 gatcgtttct gagtttatta agcctttcaa aatcgaccaa cttccactgt tcagaatagg 365161 gcttatcaag cattcagaca ctgagcatgt gctgctgttc gatatgcatc atattatttc 365221 tgatggtgca tctgtcggtg tgctgattga ggagctttca aagctgtacg acggagaaac 365281 ccttgagccg ctccgtattc aatataagga ttatgccgtg tggcagcagc agttcattca 365341 gtctgagctt tacaagaagc aagaagagca ttggctgaag gagctggacg gagagctgcc 365401 ggtgctgacg cttccgactg attacagtcg gcctgccgtt caaacatttg agggagaccg 365461 cattgcattt tcattagaag caggcaaagc tgatgctctg cgcaggcttg caaaagaaac 365521 ggattccacg ctttacatgg tgcttctggc ttcatacagt gcgtttttat caaaaattag 365581 cgggcaagac gatatcatcg tcggttcacc tgtggccgga cgatctcaag cggacgtcag 365641 ccgcgtcatc ggaatgttcg tcaatacatt ggcgctgcgc acgtatccga agggtgaaaa 365701 gacgtttgct gactatctta acgaagtgaa agaaacggca ctcagcgctt ttgatgcgca 365761 ggattaccca cttgaggatt tgatcggaaa tgttcaggtt cagcgtgaca caagcagaaa 365821 tccgttattc gatgcagttt tttcaatgca aaatgcgaat ataaaggatt taacaatgaa 365881 agggattcag cttgagccgc atccgtttga acggaaaaca gccaagtttg acctcacgct 365941 gacggctgac gaaaccgacg gagggcttac attcgtactc gaatacaata cagctctgtt 366001 taagcaggaa acgattgaac gatggaagca atattggatg gagcttttag atgcagttac 366061 tgggaacccg aaccagccgc tttccagcct gtcactggtc accgagacag aaaagcaagc 366121 gcttcttgag gcatggaagg gcaaagcgct gcctgtgccg acagacaaaa cggttcatca 366181 gctattcgaa gagactgccc agcgccacaa agaccgcccg gctgtcacat acaacggcca 366241 gtcttggacg tacggcgagc tgaatgcgaa ggcaaaccgt ctcgcgcgga ttctgatgga 366301 ctgcggcatc agcccggatg accgcgtcgg cgttctcacg aagccgtcgc ttgaaatgtc 366361 cgccgcggtg ctcggcgtct tgaaagccgg agcggcgttt gtgccgattg atcctgacta 366421 tccggatcag cggattgagt atattttaca ggacagcggc gcgaagcttc tcttgaaaca 366481 ggaaggcatt tcagtgccgg acagctatac gggagatgtc attcttctcg acggaagccg 366541 cacgattcta agcctgccgc ttgatgaaaa cgacgaggaa aatccagaaa ccgctgtaac 366601 cgcggagaac ttggcgtaca tgatttacac gtctggaacg accggacagc cgaagggtgt 366661 catggtcgag caccatgcgc ttgtgaacct gtgcttctgg caccacgacg cgttcagcat 366721 gacagcggag gaccgcagtg cgaagtacgc gggctttggg ttcgacgctt ccatttggga 366781 gatgttcccg acctggacga tcggtgccga acttcacgtc attgaggaag cgatccgcct 366841 cgatatcgtc cgcctgaacg attattttga aacgaacggc gtaacgatca cgttcctgcc 366901 gacacagctt gcggaacagt tcatggagct tgagaacaca tcacttcgcg tattgcttac 366961 tggaggagac aagctgaagc gcgcagtgaa aaagccgtac acactcgtca ataactacgg 367021 gccgacagag aatacggtcg ttgccacaag cgcagaaatc catccggagg aaggctcgct 367081 ttccatcgga agggccattg ccaatacgag agtatacatt ctcggcgagg gcaatcaggt 367141 gcagccggaa ggcgtagccg gagagctttg cgtggcgggg cgcggactgg cacgcggcta 367201 tctgaatcga gaagacgaaa ccgcgaagcg gtttgtcgct gatccgtttg tgccgggtga 367261 gcgcatgtac cgcaccggcg atttggtgaa atggacgggc ggcggcatcg aatacatcgg 367321 ccggatcgac cagcaggtca aggtccgcgg ctaccggatc gagctctcag aaattgaagt 367381 ccagctcgcc cagctttctg aggtgcagga tgcggcggtg acagctgtca aagataaagg 367441 cggcaacaca gcgatcgcgg cgtatgtcac accggaatca gctgacatag aagcactgaa 367501 atcagcactg aaggaaaccc tgccggatta catgatcccg gcgttctggg tgacgctgaa 367561 cgagcttccg gttacggcaa acggcaaagt ggaccgcaaa gccttgcctg agccggacat 367621 cgaagcggga agcggagaat acaaagcgcc gacgaccgac atggaagagc tgcttgccgg 367681 catctggcag gacgtgcttg gaatgtctga agtcggtgtc accgacaatt tcttctcgct 367741 tggcggagat tccatcaaag gaattcaaat ggcgagccgc ttgaaccagc acggctggaa 367801 gctggaaatg aaagatctct tccagcaccc gacgatcgaa gagctcaccc agtacgtaga 367861 gcgtgccgaa ggcaaacagg cagaccaagg cccggtggag ggcgaagtca tcctgacgcc 367921 gatccagcgc tggttctttg aaaagaactt cacgaacaag caccactgga accaatctgt 367981 gatgcttcac gccaagaagg gctttgatcc tgaacgggtg gagaaaacat tgcaggcgct 368041 gatcgagcat catgacgcgc tccgcatggt ctatcgtgag ggacaggaag acgtcattca 368101 atacaacaga ggtcttgaag ctgcttcagc tcaattggag gtcatccaga ttgagggcca 368161 agctgcagat tacgaagacc gaatagagag agaagcggag cgtttgcaaa gcagcatcga 368221 cttgcaggaa ggcggcttgt taaaagcagg cttgttccaa gcggaagacg gagatcactt 368281 gcttcttgcc attcaccact tagtggttga cggcgtgtcg tggcggattt tactggagga 368341 tttcgccgcg gtatatacac agcttgagca aggcaatgaa ccggttctcc cgcagaaaac 368401 acattcattt gcagagtatg cagagagatt gcaagacttc gcgaactcca aagccttttt 368461 gaaagaaaaa gagtattgga gacagcttga agaacaagct gttgcggcaa agcttccgaa 368521 agaccgcgaa tctggtgatc agcgaatgaa acatacaaag acaattgaat tctcgctgac 368581 tgctgaagag acagaacagc tcaccacaaa ggtgcatgag gcatatcaca cagaaatgaa 368641 tgatattttg ctgacggcat tcggattggc aatgaaggag tggacgggtc aagatcgagt 368701 aagtgttcat ttagaggggc atggacgtga agaaatcata gaagacctga ccatttctcg 368761 cacagtcggc tggtttacaa gtatgtaccc aatggtgctc gatatgaagc atgcggatga 368821 tctgggctac cagctgaagc aaatgaaaga agatatcaga catgtgccga ataagggagt 368881 cggatacggc attctgcgct atctgacggc accggaacat aaagaagatg tggcgttctc 368941 gattcagccg gatgtcagct tcaactattt aggtcagttt gacgaaatgt cggatgcagg 369001 tttgtttacg agatcagagc tgccatcagg acagtcatta agccctgaaa cagaaaaacc 369061 gaatgcgctg gatgttgtcg gatatatcga aaacggaaaa ctgacgatgt cactggccta 369121 tcattctctt gaatttcatg aaaaaacagt acaaacattc agtgacagct ttaaagcgca 369181 tcttctcaga atcattgaac attgcctatc tcaagatggt acggaactga ccccgagtga 369241 tcttggtgac gacgatttga cgctggatga gctggataaa ttaatggaaa ttttctaata 369301 gaggtggcat atgagcaaaa aatcgattca aaaggtgtac gcactgacac caatgcagga 369361 gggaatgctg tatcatgcga tgcttgatcc gcattcttcc tcgtacttca cacaattaga 369421 gcttgggatt cacggcgctt ttgatcttga aatctttgag aaaagcgtca atgaactgat 369481 tcggtcatac gatattctcc gtacggtatt tgtgcatcag cagctgcaaa aaccgcgtca 369541 ggtcgtgtta gcggaacgca aaacaaaagt gcattatgag gatatcagtc atgcagacga 369601 aaaccgccag aaagagcaca ttgagcgtta caaacaagac gttcagcgcc aaggctttaa 369661 cctggcaaaa gacatattgt tcaaggtagc ggttttccgc cttgctgcag atcagctgta 369721 tcttgtctgg agcaatcatc atattatgat ggacggctgg agcatgggcg tcctcatgaa 369781 aagcctgttc caaaactatg aagcgctcag agcaggcagg acaccggcaa acggtcaggg 369841 caagccttat tccgattaca tcaagtggct tggaaaacag gacaatgaag aagcggagag 369901 ctactggagc gagcgcttgg cgggttttga acagccaagc gtgctcccgg gccgcctgcc 369961 tgtgaaaaaa gacgaatacg tcaataaaga atattcattt acatgggacg aaacactggt 370021 tgcccgtatt cagcaaaccg caaatctcca tcaagtgaca gggcctaacc tatttcaggc 370081 cgtttggggc attgttctca gcaaatacaa ctttacggat gatgtgatct tcggaacggt 370141 cgtctcggga cgaccgtctg aaatcaacgg aatcgaaacg atggcggggc tgtttatcaa 370201 caccattcca gtgcgggtga aagttgaacg agatgctgca ttcgctgata ttttcacagc 370261 tgttcagcag catgcagtag aggcagagcg ttacgattac gtgccgctct atgagattca 370321 aaaacgctca gctcttgatg gcaatctctt aaaccatctg gtcgcgtttg aaaattatcc 370381 gcttgatcaa gagcttgaaa acggcagcat ggaagaccgc ctcgggtttt cgattaaggt 370441 agaaagcgca tttgaacaaa cgagcttcga tttcaacctg attgtgtatc cgggcaaaac 370501 gtggaccgtc aaaattaaat ataacggagc cgcctttgat tccgctttta tcgaacggac 370561 agcggagcac cttacccgca tgatggaagc agctgtcgat cagccggccg cttttgtgcg 370621 tgagtacggg cttgtgggag acgaagagca gcggcaaatt gtcgaggtgt ttaacagcac 370681 gaaagccgaa ctccctgaag gaatggctgt tcaccaagtg tttgaagagc aagcgaaacg 370741 gacgccggcg agcaccgccg tcgtatatga aggaaccaag ctgacgtacc gcgagctgaa 370801 tgcagcggct aaccgtctgg cgagaaagct tgtcgaacat gggcttcaaa aaggggaaac 370861 agcagcgatt atgaacgacc gctcagtaga aaccgttgtc ggcatgctgg ctgttttaaa 370921 agcaggcgcc gcatatgtgc cgcttgatcc agcgcttcct ggggatcgtc ttcgtttcat 370981 ggcagaggac agctccgttc gaatggtttt gatcggaaat tcttatacag ggcaggcaca 371041 tcagctgcaa gtgccggttc ttacactgga cataggcttt gaagagagtg aagcggctga 371101 caatctcaac ctgccatccg ccccgtctga tttggcgtac atcatgtaca catccggttc 371161 aacgggcaaa ccgaaaggcg tcatgatcga acataaaagc attctgcgcc tcgtcaaaaa 371221 tgccgggtac gttcctgtta ctgaagaaga ccgcatggcg caaacgggag ctgtcagctt 371281 tgatgccgga acgtttgagg tattcggcgc actgctgaat ggcgcagcac tttatccggt 371341 caaaaaagag acactgcttg atgcgaaaca atttgctgca ttcctgcgtg agcaaagcat 371401 cacaactatg tggctgacat cacctttatt caaccagctt gctgcaaagg atgcgggtat 371461 gttcggcaca ctgcgccatt taatcatcgg cggagatgcc cttgtcccgc atattgtcag 371521 caaagtaaaa caggcatcgc cgtcgctttc attgtggaac ggatacggcc cgacagaaaa 371581 cacgacgttt tcaaccagtt ttctgatcga ccgcgagtat ggcggctcta tcccaatcgg 371641 gaagccgatc ggaaattcca ctgcctatat tatggatgag cagcaatgcc tgcagccaat 371701 cggcgcgcct ggtgagcttt gcgtaggcgg aatcggtgta gcgcgtgggt atgtcaatct 371761 ccctgagctg acggagaagc aatttctgga agacccgttc agaccgggtg agagaattta 371821 ccgcactggt gacttggcaa gatggctgcc ggacggcaat atcgaatttt taggcagaat 371881 cgacaaccaa gtgaaggtgc gcggcttccg aattgagctt ggcgaaattg aaacaaaact 371941 gaacatggct gagcatgtga cagaagccgc ggtgatcata cgcaagaaca aagcagacga 372001 aaatgaaatt tgcgcgtact tcacggcgga tcgtgaagtg gctgtgagtg agctgagaaa 372061 aacactgtct cagtctttgc ctgactatat ggtccctgcc cacctgattc aaatggacag 372121 cctgccgctc acgccaaacg ggaaaatcaa caaaaaggaa ctgcctgcac cgcaatcaga 372181 agccgtgcag ccggaatacg cagcaccaaa aacagagagt gaaaagaaat tagcggagat 372241 ctgggaagga atactcggcg tcaaagcagg cgttaccgat aacttcttta tgatcggcgg 372301 ccattctttg aaagcgatga tgatgacggc gaaaattcaa gagcattttc ataaggaagt 372361 tccgataaaa gtgctttttg aaaagccgac tattcaagaa ctggcactgt atttggaaga 372421 gaacgaaagc aaggaggagc agacgtttga accgatcagg caagcatctt atcagcagca 372481 ttatcctgta tccccggccc agcggagaat gtatatcctc aatcagcttg gacaagcaaa 372541 cacaagctac aacgtccccg ctgtacttct gctggaggga gaagtagata aagaccggct 372601 tgaaaacgcg attcagcaat taatcaaccg gcacgaaatc ctccgtacat cgtttgacat 372661 gatcgacgga gaggttgtgc aaaccgttca taaaaacata tcgttccagc tggaggctgc 372721 caagggacgg gaagaagacg cggaagagat aatcaaagca tttgttcagc cgtttgaatt 372781 aaaccgcgcg ccgctcgtcc gttcgaagct tgtccagctg gaagaaaaac gccacctgct 372841 gctcattgat atgcatcata ttattactga cggaagttca acaggcattc taatcggtga 372901 tcttgccaaa atatatcaag gcgcagatct ggaactgcca caaattcact ataaagatta 372961 cgcagtttgg cacaaagaac aaactaatta tcaaaaagat gaggaatact ggctcgatgt 373021 ctttaaaggc gaactgccaa tactggatct tcccgcggat ttcgagcggc cagctgaacg 373081 gagctttgcg ggagagcgcg tgatgtttgg gcttgataag caaatcacgg ctcaaatcaa 373141 atcgctcatg gcagaaacag atacgacaat gtacatgttt ttgctggcgg cgttcaatgt 373201 actcctttcc aagtacgcgt cacaggatga tatcattgtc ggctcgccga cagctggcag 373261 aacacatcct gatctgcaag gtgtgccggg tatgtttgtc aacacggtgg cactcagaac 373321 ggcaccagcg ggagataaaa ccttcgcgca attccttgaa gaggtcaaaa cagccagcct 373381 tcaagcattc gagcaccaga gctatccgct tgaggagctg attgaaaagc ttccgcttac 373441 aagggataca agcagaagtc cgctgttcag cgtgatgttc aacatgcaga atatggagat 373501 tccttcatta agattaggag atttgaagat ttcctcgtat tccatgcttc atcatgttgc 373561 gaaatttgat ctttccttgg aagcggtcga gcgtgaagag gatatcggcc taagctttga 373621 ctatgcgact gccttgttta aggacgagac gatccgccgc tggagccgcc actttgtcaa 373681 tatcatcaaa gcggccgcgg ctaatccgaa cgttcggctg tctgatgtag atctgctttc 373741 atctgcagaa acggctgctt tgctagaaga aagacatatg actcaaatta ccgaagcaac 373801 ctttgcagca ctttttgaaa aacaggccca gcaaacacct gaccattctg cggtgaaggc 373861 tggcggaaat ctgttgacct atcgcgagct tgatgaacag gcgaaccagc tggcgcatca 373921 tcttcgtgcc caaggggcag gaaatgaaga catcgtcgcg attgttatgg accggtcagc 373981 tgaagtcatg gtatccattc tcggtgtcat gaaggcgggg gcagctttcc ttccgattga 374041 tcctgataca cctgaagaac gaatccgtta ttcattagag gacagcggag caaaatttgc 374101 ggtcgtgaat gaaagaaaca tgacggctat tgggcaatat gaagggataa ttgtcagcct 374161 tgatgacggt aaatggagaa atgaaagcaa ggagcgccca tcatccattt ccgggtctcg 374221 caatcttgca tacgtcattt atacgtccgg tacgaccgga aagccaaagg gcgtgcagat 374281 tgagcatcgt aatctgacaa actatgtctc ttggtttagt gaagaggcgg gcctgacgga 374341 aaatgataag actgtattgc tttcatctta cgcatttgac cttggctata cgagcatgtt 374401 ccctgtactt ctgggcgggg gcgagctcca tatcgtccag aaggaaacct atacggcgcc 374461 ggatgaaata gcgcactata tcaaggagca tgggatcact tatatcaagc tgacaccgtc 374521 tctgttccat acaatagtga acaccgccag ttttgcaaaa gatgcgaact ttgaatcctt 374581 gcgcttgatc gtcttgggag gagaaaaaat catcccgact gatgttatcg ccttccgtaa 374641 gatgtatgga cataccgaat ttatcaatca ctacggcccg acagaagcaa cgatcggcgc 374701 catcgccggg cgggttgatc tgtatgagcc ggatgcattt gcgaaacgcc cgacaatcgg 374761 acgcccgatt gcgaatgccg gtgcgcttgt cttaaatgaa gcattgaagc ttgtgccgcc 374821 tggagcgagc ggacagctct atatcacggg acaggggctc gcgagagggt atctcaacag 374881 gcctcagctg acagccgaga gatttgtaga aaatccatat tcgccgggaa gcctcatgta 374941 caaaaccgga gatgtcgtac gaagactttc tgacggtacg cttgcattta tcggccgggc 375001 tgatgatcag gtgaaaatcc gaggctaccg cattgagccg aaagaaattg aaacggtcat 375061 gctcagcctc agcggaattc aagaagcggt tgtactagcg gtttccgagg gcggtcttca 375121 agagctttgc gcgtattata cgtcggatca agatattgaa aaagcagagc tccggtacca 375181 gctttcccta acactgccgt ctcatatgat tcctgctttc tttgtgcagg ttgacgcgat 375241 tccgctgacg gcaaacggaa aaaccgacag aaacgctctg ccgaagccta acgcggcaca 375301 atccggaggc aaggccttgg ccgcaccgga gacagcgctt gaagaaagtt tatgccgcat 375361 ttggcagaaa acgcttggca tagaagccat cggcattgat gacaattttt tcgatttagg 375421 cggccattca ttaaaaggga tgatgctgat tgccaacatt caggcggaat tggagaaaag 375481 cgtaccgctt aaagcactgt tcgagcagcc gacagttcgc cagctggcgg cttatatgga 375541 ggcgtctgct gtttcaggcg gccatcaagt actcaaaccg gctgacaagc aggatatgta 375601 tccattgtca tccgcacaga aacgaatgta cgtgctcaat cagcttgacc gccagacgat 375661 aagctacaac atgccatctg ttcttctaat ggaaggagag cttgatattt cgcgcctgcg 375721 cgactcactc aatcagcttg tgaaccgtca cgaatcattg cggacgtcat ttatggaagc 375781 taatggtgag cctgttcagc gcatcattga gaaggcggag gttgatcttc atgtgtttga 375841 agccaaagaa gacgaagcgg accaaaagat taaggaattt atccggccat tcgacttaaa 375901 cgacgcaccg ctcattcgcg cagctttgct tcgaatagaa gcgaaaaaac atttgctgct 375961 tttagatatg catcatatca tcgcagacgg cgtctcaaga ggcatctttg taaaagaatt 376021 ggcgctgctt tacaaaggag agcagcttcc ggagccgacg cttcattata aagatttcgc 376081 cgtttggcaa aatgaagctg agcaaaaaga acggatgaag gagcatgagg cgtactggat 376141 gtcagttctt tcaggcgagc tgccagagct tgatctcccg ctcgattatg cccgtccgcc 376201 tgtgcaaagc tttaaaggag atacgatccg tttccgtacg ggaagtgaga cggcaaaggc 376261 ggtagaaaaa ctgcttgccg aaaccggaac gaccttgcac atggtgctcc atgctgtttt 376321 ccacgtcttt ttaagcaaaa tttccggaca gcgggatatc gtcatcggct ccgttactgc 376381 cggccggacg aatgctgatg ttcaggacat gccgggaatg ttcgtcaata cacttgccct 376441 gagaatggaa gcgaaagaac agcaaacatt tgcggagctt ttggagctag caaagcagac 376501 gaacctgtca gcccttgagc atcaggagta tccgtttgaa gatctggtta atcagcttga 376561 tctccctcgg gatatgagcc gaaacccatt gtttaatgtg atggtgacga cagaaaaccc 376621 tgataaagaa cagcttacat tgcaaaatct gagcatttca ccttatgagg ctcatcaggg 376681 aacttctaag tttgatctga cactgggcgg atttactgat gaaaatggca ttggcttgca 376741 gctcgaatat gcgacagatc tgttcgcaaa agaaacagct gaaaaatgga gcgaatacgt 376801 tctgcggcta ctaaaggctg ttgcggataa cccgaaccag ccgctttcca gtctgttact 376861 ggtcaccgag acagaaaagc aagcgcttct tgaggcatgg aagggcaaag cgctgcctgt 376921 gccgacagac aaaacggttc atcagctatt cgaagagact gtccagcgcc acaaagaccg 376981 cccggctgtc acatacaacg gccaatcttg gacgtacggc gagctgaacg cgaaggcaaa 377041 ccgcctcgcc cggattctga tggactgcgg catcagcccg gatgaccgcg tcggcgttct 377101 cacgaagccg tcgcttgaaa tgtccgccgc ggtgctcggc gtcttgaaag ccggagcggc 377161 gtttgtgccg attgatcctg actacccgga tcagcggatt gagtatattt tacaggacag 377221 cggcgcgaag cttctcttga aacaggaagg catttcagtg ccggacagct atacgggaga 377281 tgtcattctt ctcgacggaa gccgcacgat tctaagcctg ccgcttgatg aaaacgacga 377341 gggaaatcca gaaaccgctg taaccgcgga gaacttggcg tacatgattt acacgtctgg 377401 aacgaccgga cagccgaagg gtgtcatggt cgagcaccat gcgcttgtga acctgtgctt 377461 ctggcaccac gacgcgttca gcatgacagc ggaggaccgc agtgcgaagt acgcgggctt 377521 cgggttcgac gcttccattt gggagatgtt cccgacctgg acgatcggcg ctgaacttca 377581 cgtcattgat gaagcgatcc gcctcgatat cgtccgcctg aacgattatt ttgaaacgaa 377641 cggcgtaacg atcacgttcc tgccgacaca gcttgcggaa cagttcatgg agcttgagaa 377701 cacatcactt cgcgtcctct tgaccggagg agacaagctg aagcgggcag tgaaaaagcc 377761 gtacacactc gtcaacaact acgggccgac agaaaatacg gtcgttgcca caagcgcaga 377821 aatccatccg gaggaaggct cgctttccat cggacgggcc attgccaata cgagagtata 377881 cattctcggc gagggcaatc aggtgcagcc ggaaggcgta gccggagagc tttgcgtggc 377941 ggggcgcgga ctggcacgag gctatctgaa tcgagaagac gaaaccgcga agcggtttgt 378001 cgctgatccg tttgtgccgg gtgaacgcat gtaccgcacc ggcgacttgg tgaagtgggt 378061 gaacggcggc atcgaataca tcggccggat cgaccagcag gtcaaggtcc gcggctaccg 378121 gatcgagctc tcagaaattg aagtccagct cgcccagctt tctgaggtgc aggatgcggc 378181 ggtgacagct gtcaaagata aaggcggcaa tacagcgatc gcggcgtatg tcacaccgga 378241 aacagctgac atagaagcac taaaatcaac actaaaggaa accctgccgg attacatgat 378301 cccggcgttc tgggtgacgc tgaacgagct tccggttacg gcaaacggca aagtcgaccg 378361 caaagccttg cctgagccgg acatcgaagc gggaagcgga gaatacaaag cgccgacgac 378421 cgacatggaa gagctgcttg ccggcatctg gcaggacgtg cttggaatgt ctgaagtcgg 378481 tgtcaccgac aatttcttct cgcttggcgg agattccatc aaaggaattc aaatggcgag 378541 ccgcttgaat cagcacggct ggaagctgga aatgaaagat ctcttccagc atccgacgat 378601 cgaagagctc acccagtacg tagagcgtgc cgaaggcaaa caggcagacc aaggcccggt 378661 ggagggcgaa gtcatcctga cgccgatcca gcgctggttc tttgaaaaga acttcacgaa 378721 caagcaccac tggaaccaat cggtgatgct tcacgccaaa aagggctttg atcctgaacg 378781 ggtggagaaa acattgcagg cgctgatcga gcatcatgac gcgctccgca tggtctaccg 378841 cgaggaaaac ggggacatcg ttcaggtgta taaaccgatc ggtgagagca aggtcagctt 378901 cgaaatcgtg gatctgtacg gctccgatga agagatgctg agaagccaga ttaagcttct 378961 cgcgaacaag ctgcaaagca gtctcgatct gcgaaacggg ccgcttttaa aggcggagca 379021 atatcgcaca gaagctgggg atcacctgct cattgctgta caccatctcg tggtcgacgg 379081 tgtgtcatgg cggattttgc ttgaagactt tgcttcaggc tacatgcagg ctgagaaaga 379141 agagagcctt gtcttcccgc aaaaaacaaa ctccttcaag gattgggcgg aagaactggc 379201 ggcattcagc caatcagcgc atcttttaca gcaggctgaa tactggtcgc aaattgccgc 379261 tgaacaggtt tctcctttac ctaaggattg tgaaacagag cagcggatcg tcaaggatac 379321 atcatctgtc ctatgtgaat taacggcaga agacactaag catcttttaa cagatgttca 379381 tcagccatat ggaactgaaa tcaacgatat tcttctcagc gcgctcggtt tgacaatgaa 379441 agaatggaca aagggggcca aaattggcat taaccttgag ggacacggcc gggaggacat 379501 tatcccgaat gtgaatatct ccagaacggt cggctggttt acggcacaat accctgttgt 379561 gctcgacata tctgacgcag atgcctcagc tgtgatcaaa acagtcaaag aaaacctgcg 379621 ccgcattccg gacaaaggtg ttggctacgg cattcttcgt tatttcacag aaacagcgga 379681 aacaaagggc ttcacaccgg agatcagctt caactatttg ggccaattcg acagtgaagt 379741 caaaaccgat ttctttgaac cgtccgcttt cgatatgggg cgccaagtaa gcggagaatc 379801 agaggcgctg tacgcattaa gcttcagcgg catgatcaga aacggccggt ttgtgctttc 379861 ctgctcctac aatgagaagg agtttgaaag agctacagtc gaggagcaaa tggaacggtt 379921 taaagaaaac ctcctgatgc taatccgcca ttgcacggaa aaagaagaca aggaattcac 379981 accaagcgac ttcagcgccg aagaccttga aatggacgag atgggagata tctttgacat 380041 gcttgaggag aatttaaaat aaaacgcaag ggaattacag aaggcgggag cgaaacatat 380101 gagtcaattt agcaaggatc aggttcaaga tatgtattac ctatcgccga tgcaggaagg 380161 gatgcttttt catgccatcc tgaatcccgg ccaaagcttt taccttgaac aaatcacgat 380221 gaaagtaaaa ggcagcttga atatcaaatg tcttgaagaa agcatgaatg tgatcatgga 380281 ccggtacgat gtatttcgta ccgtgttcat tcacgaaaaa gtaaaaaggc ctgtccaagt 380341 cgtattgaaa aaacggcagt tccatataga agaaatcgat ctgacacact taacgggcag 380401 cgagcaaaca gccaaaatca atgagtacaa agaacaggat aagatcaggg gttttgattt 380461 gacgcgggat attccgatgc gggcagccat tttcaagaaa gctgaagaaa gctttgaatg 380521 ggtgtggagc taccaccaca ttattttgga cggatggtgc ttcggcatcg tcgtacagga 380581 tctatttaag gtatacaatg ctctgcgcga acaaaagccg tacagcctgc cgcccgtcaa 380641 accgtataaa gactacatca agtggcttga aaagcaggat aaacaagcat cactgcgtta 380701 ctggcgcgaa tatttagagg gctttgaagg acaaacgacg tttgcggagc aaagaaagaa 380761 acaaaaggac ggctatgagc cgaaagagct gctcttttca ctgtcggagg cggaaacaaa 380821 ggcctttacc gagcttgcaa aatcgcagca taccactttg agtacggcgc tgcaggcagt 380881 ctggagcgta ttgatcagcc gctatcagca gtctggcgat ttggccttcg gtacagttgt 380941 ttcagggcgt cccgcggaaa tcaaaggcgt tgaacatatg gtcgggctgt ttatcaacgt 381001 tgtcccgaga cgtgtgaagc tgtctgaggg tatcacattt aacggcttgc tcaagcggct 381061 gcaggagcaa tcgctgcagt ccgagccgca tcaatatgtg ccgctttatg acatccaaag 381121 ccaggccgat cagccgaaac tgattgacca catcattgtt tttgagaact atccgcttca 381181 ggatgcgaaa aatgaagaaa gcagtgaaaa cggctttgat atggtggatg ttcatgtttt 381241 tgagaagtcg aattatgatc tcaacctgat ggcttccccg ggagatgaga tgctgattaa 381301 gcttgcctat aatgagaatg tgtttgatga ggcgtttatc ctgcgcttga aatctcagct 381361 tcttacagca attcagcagc tcatccagaa tcctgatcag cctgtcagca cgatcaacct 381421 cgttgacgac agggagagag aatttttgct aaccggctta aacccgccgg ctcaagctca 381481 tgaaacaaag cctctgacgt attggttcaa ggaagcagtg aacgccaatc cggatgcacc 381541 ggcgcttacg tattccggcc agaccctgtc ttatcgcgaa ttagatgagg aagcgaaccg 381601 cattgcacgc cggctgcaaa aacacggtgc gggcaaaggc tctgttgtag cgctgtacac 381661 gaagcgctca cttgaactgg tgatcggcat tctcggtgta ttaaaggcgg gagcagccta 381721 tctgccggtt gatccgaagc tgccagagga ccgaatctcg tatatgctgg ctgacagtgc 381781 ggcagcctgt cttctgacgc atcaggagat gaaagaacaa gcggctgagc tgccgtatac 381841 aggcacaacg ctcttcattg atgatcaaac acggtttgaa gaacaggcaa gcgatcctgc 381901 aaccgcgatt gatcctaatg atccggcata tatcatgtac acgtccggca caaccggaaa 381961 gccaaagggc aatatcacca ctcatgccaa tattcaagga ttggtcaagc atgtagacta 382021 catggcattt tctgatcagg atacgttctt gtctgtttcg aattacgcct ttgatgcatt 382081 tacctttgat ttctatgctt ctatgctgaa tgcggcacgg ctcattatcg cagatgaaca 382141 tacgctgctt gatacagaac ggctcacaga tctgatcctg caagagaatg tcaatgtcat 382201 gtttgcgaca accgcactat ttaatcttct cacagatgcg ggagaggatt ggatgaaggg 382261 gcttcgctgt atattattcg gcggagagcg cgcgtcagtg cctcatgtca gaaaagcgct 382321 gcggatcatg gggccgggca agctgattaa ctgctacggg ccgactgagg gaacagtgtt 382381 tgcgacagct cacgtcgtgc atgatctgcc ggattccatc tcctcattgc cgatcggaaa 382441 gccgatcagc aatgccagtg tttatattct gaatgagcaa agccagctcc agccattcgg 382501 ggcggtcggt gaactgtgca tcagcggaat gggcgtgtca aaagggtatg taaatcgtgc 382561 tgacctcacg aaggaaaagt ttatcgagaa cccgttcaag ccgggagaaa cgctttaccg 382621 tacaggggat ttagcgcgct ggctgccgga tggaacgatt gaatacgccg gccgtattga 382681 cgaccaggtc aaaatacgcg gacaccggat tgagcttgaa gaaatcgaaa agcagctgca 382741 ggaataccca ggtgtgaaag atgcggtcgt tgtggcggac cgccatgagt ctggcgatgc 382801 atcaatcaat gcctaccttg tgaaccgaac gcagctttca gctgaagacg tgaaggcgca 382861 cctgaaaaaa cagcttcctg cttacatggt gccgcaaacc tttaccttct tggatgagct 382921 tcctttaacg acgaacggga aagtcaataa acggctgctc ccaaaacctg atcaggatca 382981 gctggcggaa gaatggattg gaccgcggaa cgagatggaa gaaacaatcg cacaaatatg 383041 gtctgaggtt ctcggcagaa agcaaattgg cattcatgac gatttctttg cgctcggagg 383101 gcattccttg aaggccatga ccgccgcgtc ccgcatcaag aaagagctcg ggattgatct 383161 tccagtgaag cttttgtttg aagcgccgac gatcgccggc atttcagcgt atttgaaaaa 383221 cgggggctct gatggcttgc aggatgtaac gataatgaat caggatcagg agcagatcat 383281 tttcgcattt ccgccggttc tgggctatgg ccttatgtac caaaatctgt ccagccgctt 383341 gccgtcatac aagctatgcg cctttgattt tattgaggag gaagaccggc ttgaccgcta 383401 tgcggatttg atccagaagc tgcagccgga agggccttta acattgtttg gatattcagc 383461 gggatgcagc ctggcgtttg aagctgcgaa aaagcttgag gaacaaggcc gtattgttca 383521 gcggatcatc atggtggatt cctataaaaa acaaggtgtc agtgatctgg acggacgcac 383581 ggttgaaagt gatgtcgaag cgttgatgaa tgtcaatcgg gacaatgaag cgctcaacag 383641 cgaagccgtc aaacacggcc tcaagcaaaa aacacatgcc ttttactcat actacgtcaa 383701 cctgatcagc acaggccagg tgaaagcaga tattgatctg ttgacttccg gcgctgattt 383761 tgacatgccg gaatggcttg catcatggga agaagctaca acaggtgttt accgtgtgaa 383821 aagaggcttc ggaacacacg cagaaatgct gcagggcgaa acgctagata ggaatgcgga 383881 gattttgctc gaatttctta atacacaaac cgtaacggtt tcataaatga agtgatgaaa 383941 ggaggagaca gccaatgagc caactcttca aatcatttga tgcgtcggaa aaaacacagc 384001 tcatctgttt tccgtttgcc ggcggctatt cggcgtcgtt tcgccctctc catgcttttt 384061 tgcaggggga gtgcgagatg ctcgctgccg agccgccggg acacggcacg aatcaaacgt 384121 cagccattga ggatctcgaa gagctgacgg atttgtacaa gcaagaactg aaccttcgcc 384181 ctgatcggcc gtttgtgctg ttcggacaca gtatgggcgg aatgatcacc ttcaggctgg 384241 cgcaaaagct tgagcgtgaa ggcatctttc cgcaggcggt tatcatttct gcaatccagc 384301 cgcctcatat tcagcggaag aaagtgtccc acctgcctga tgatcagttt ctcgatcata 384361 ttatccaatt aggcggaatg cccgcagagc ttgttgaaaa taaggaggtc atgtcctttt 384421 tcctgccttc tttccgatca gattaccggg ctcttgaaca atttgagctt tacgatctgg 384481 cccagatcca gtcgcctgtt catgtcttta acgggcttga tgataaaaaa tgcatacgag 384541 atgcggaagg gtggaagaag tgggcaaaag acatcacatt ccatcaattt gacggcgggc 384601 acatgttcct gctgtcacaa acggaagaag tcgcagaacg gatttttgcg atcttgaatc 384661 agcatccgat cattcaaccg tgatcaaaag cggacagctt cggctgttcc gctttttttg 384721 tgttgaatgc caatttctgc atggtataat agtcgaaata ctcaaataaa ggcaggtcga 384781 aacatgcgca cgtctcccag gatgaaatgg tttgtattgc tgtttacgtt tgttttcgcc 384841 atcggaatga actcattcag aaattccttt caatttttta tgctgccaat ggcagacgcc 384901 ttccatgccg acaggtcgct gatttcggtt tctgtcagca tttttatgat cacaaccggc 384961 atcgtccagt tttttgtcgg tttttttatc gaccgtttca gtgtcagaaa aattatggcg 385021 ctgggagctg tttgcatcag cgcaagcttt ttggtgcttc cttattcacc gaatgttcat 385081 gtgttttccg ccatttacgg tgtgcttggc ggaatcgggt attcctgcgc ggtcggcgtg 385141 acgacccagt atttcatcag ctgttggttt gacacacaca aaggtctggc gcttgctatt 385201 ttgaccaatg ccaactctgc gggcctgctg cttctctcgc ccatttgggc tgcggctccg 385261 tatcatgccg gctggcagag cacctatacc attttgggaa tcgtcatggc ggctgttctg 385321 ctgccgctcc tcgtctttgg gatgaagcac ccgccacatg cgcaagcgga aactgtgaaa 385381 aaatcttatg attggcgagg gttttggaac gtgatgaagc aatcccgcct cattcatatc 385441 ctgtacttcg gcgtgtttac ttgcggattt acaatgggaa ttattgatgc tcacctcgtc 385501 ccgatactga aggatgcgca tgtctctcat gtcaacggaa tgatggccgc gttcggggca 385561 tttatcatca ttggcggatt attggcgggc tggctgtcag atctcctcgg cagcagaagc 385621 gtcatgctat ccatcttatt tttcattcgg ctgctcagcc tcatttgcct gctcattccc 385681 attctcggaa ttcatcacag cgacctttgg tacttcgggt ttatcctgtt attcgggctc 385741 agttacacag gcgtgatccc gctgaccgcg gcgtcaattt cggaaagcta tcaaacagga 385801 ttgatcggat cgctgttagg catcaatttc tttatccatc aggttgccgg agctctcagc 385861 gtgtatgcgg gcggtttgtt ttttgacatg actcatggtt atttactgat tgtcgctgtg 385921 tgcatcgtgt ttgtgggttt atcggctgta atagagctgg tgccgttttt agataaacag 385981 aaggcaaaag aaacccacca ttcaatataa aaggatcagc actgtcaatg ctgatccttt 386041 ttaaatttga gtttttttgt ttcggtattt ttaaggataa tctccttgaa tctgttcatc 386101 tcctcttcgg agtgaaaaaa atgtttgggg atcgcaatat attggccact tgatgtattg 386161 accctgaaga tatttttata ttcgaaaaca gctgtaattt catcccaatt gaaaatgagg 386221 tcatattttt tagaacatat acgaattcct tcttggttca gagtatatgt tcttttggat 386281 ttcatccgtt cgttcttctt gtatgctctg gaaaacttca catatagaag aaggaggagc 386341 agcagtgtaa acagaacgga catcacgata atcaacatac tgttcataaa caagttaagc 386401 gcgtcacttc cataaacgat acggggccat ccgttaatga agttaactgc agcaaatatg 386461 gcgcaaaaca atagaaagta aaagcatgat atttttgcga tttgataaaa aaagatttct 386521 cttacatcct taaaagtgat ttctcctgga agattgatac tttcactagc atattgaatc 386581 atacggtaaa cctacacctc taaccatgtt tttcctttta gtctagcata atttctcatt 386641 tttttgcagg cataccaggg cgctttgttt ttttctccag attgatattg ctccccacca 386701 cgccaatcat aatacaaaca gccccggcaa gatgatacca ggccaggctt tcgttgagaa 386761 tcacaaatcc tgcaatcatc gtcacaatgg tagatacatg attaaaagcg ctcattttaa 386821 acgcctcaat tcgcgacagc gtatagttag acagaaatga agtgacaagt gaagacagca 386881 cgcccaaata cacaatggcg agaacgaagc cgggctcccg gaacggcaga aaataagtgc 386941 cgactgttcc cgccgctccg tgacgcacaa gggcgatggc gttgaagacg acaaagccga 387001 tggctgacat gatgtaggtg agctcggtca gcttgaaccg ctgcgtcatt tttctggcag 387061 cagtattgta catcgctgaa gacaaagcgg acaataggat cagcaaagac ccttttaagc 387121 tggctgattc cacgtcaacg cctttcatca caaaaataaa catgacgccg gcaacggata 387181 aaaccgtgaa ccccttttgc gtccacgttg ggcgttcctt taaaacataa gcggcaaaga 387241 ccatcgtgaa aatcggaatg gctgcctgaa taattcccgc ttcagaggag gacgagtaca 387301 caaggccgaa tgcctgaaag ctgaaaaata acgcgggata cagcagggcg agcggcaaaa 387361 tgtcaatgac gtcctttacg cggattgata gctttaccca gccgaataag atcggtacag 387421 tggccgcagc aaacgcaatg gtgaaccgat gcgccaaaat atcaaacggc tctgctgttt 387481 gcagtgcgat ttttacgaat agaaaggata aaccgataat gaacgaatat aaaatagccg 387541 ctatataagc gggggtttgc tgatgtttaa ccataatggg aagggctcct ttacctgaat 387601 tgcagcgccg gtcgctccct ttattgtatg gccgcggtca gaacggtaca atgagaaaaa 387661 caatgaactg taccggtaca aaacaggggg agaaggcatg gagaaatata tgagtctatt 387721 aacgaggata gaggagatga tgcaaagcac ctcatatcaa gaaggagaca ggcttccatc 387781 tatccgtcag ctgtccgccc gctaccaagt cagcaaaagc acagtgatcc gcgcgctgca 387841 ggagctggaa aagcgccacc ttatctattc tgttccgaaa agcggctatt atattgtgaa 387901 aaagtcaggg aaatcaaaaa gcgggcagcc tggccccatc gactttgcca catctgcgcc 387961 ggatcccgat gtgtttccgt atcttgattt tcagcactgc atcaacaaag cgattgatac 388021 atacaaaaac gatttgttta tttatgggac gccaaagggg cttccatcac tcatccgcgt 388081 actccgaaag ctcttggcca ctcaacaggt atttgcggat gaacggcata ttttcattac 388141 atcaggtgtc cagcaggcgt tatccttgct ttgtgccatg ccgttcccaa atgggaaaga 388201 gaagatcgcc attgaacagc cgggctacca tttgatggtc gaacagcttg agacacttgg 388261 gattcccgcc atcggggtga aacgaacgga agaagggctt gatatagcca aggttgagcg 388321 gttatttcaa acagaatcga ttaaattttt ttatacgatg ccgcgcttcc ataacccgct 388381 tgggtgctca ttgtcagagc gtgataaaca ggagcttgtg agactggcag aagcgtatga 388441 tgtctatctc gttgaggatg attacctcgg tgatctggag gaaaataaaa aggcagatcc 388501 gctgtacgca tatgatctgt cctcacatgt catctatttg aaaagcttct cgaaaatgat 388561 gttccccggc ctccgcgtgg gggcggctgt tttgcccgaa gcgctgactg acacgttcta 388621 tgcgtacaaa aagctgaacg acatcgactg ttcgatgatt tctcaagcgg cattggagat 388681 ttacctgaaa agcggtatgt acggcaggca taaggagaaa atcagagatt cttataaaga 388741 gcggtcgctg aggctacatc aagccattcg aactcacagg cagctgggaa gcggacgctt 388801 tacgttctcc agcgggcagg caccctgtat gcacacccat ctggtgcttc ctcaggatct 388861 gcccgcctca agagtgattc atagactgga aaaacaaggg gttctccttg aggcgataga 388921 ccgtcattat ttatcagatt atccgaaaga aaatctatta aaaatcaata tttccaatgt 388981 gaaaacggaa gatattgagc gcggtgtcaa gctgttgatg agccatttat aaaagctctt 389041 cgtacgagac cattgtgata tcctcgggga aatcagggtg tacggcgcat acagccattt 389101 tgtagccggg atcgacctca tacgttttga tatagcatgg ggaatggctg tccggaagct 389161 caatggatac ttgtccgtcc tggtgcaggc gcactgaaaa ggaatcaagc ggaagcgata 389221 agcctttgcc ttccttgttt gataaagctt tctttcattg accatagatg ataaaaatag 389281 tctgtctgct cgtccttgtc ttttgctaaa aggtcgctgt actctgtttt tgaaaagaag 389341 cgcttggcga tctcaaggct gatcggtttc gttttttcga tatctatgcc gatcggctgt 389401 gaatcaaacg cgcaaatgac ccagcgtccg gagtgagaaa tgttgaaatg agcgtcggga 389461 agatcaggga tgcacggctt cccgtattcc tgcgtgctaa agcggatatc ggatttgtcc 389521 aactgatact gcctgcttat gactgagcga acgagcacat ctcccagcag ggtgcggtga 389581 gcatcttctt tatgataaaa tctccggcat ttctcccgtt tttcaggtga tatgaaagac 389641 atgaaccgtt cattttcttc ctgtgaaagc gggcggtcca tataaattcc gtaaatcttc 389701 attctagatc ctccgtctgc aaaagattgt caaaaccatc ctatcatact tccacaagac 389761 tcatatagag gagaaaataa aaaaacaaag ccaaggcggc tttgttttag tgtacaggcg 389821 gagatgcttt cactgcggct gtccgccttg ccacagcata attcagcaac tggattgact 389881 ggggcaatga aaaacgcaaa ataagtccgg tgaggatggc ggtcaaaatg gtgccaaaac 389941 cgatcggtcc gcccatgccc catgccgcaa acaaaatggt taattccatg ccgttccgca 390001 cccattgcac attccagccg gttttttctg taatcagcat catcagtgaa tcacgcggcc 390061 ccgcgccaag gcctgctgat acataaacac cgacgccgta accaatcagc accacgccta 390121 gagagaagac gatgatcgag cctgtgtagg tcgagagggc aggcagaatg aaattgaaaa 390181 aatctataaa tacaccaatg agcaccatat tcaggagggc accaattttc ggccaagctc 390241 tcgtaaacaa tgacgtgaat ccgacgatga gcgctccaat aatgatggac cactggccga 390301 cggtaagccc gaagtgctga aacaggctgt aatgaaatgc atcccacgga ctaatgccga 390361 gtgcttttcc ttctatcgtc agggatacac caaaagccaa aatgatcaaa ccggcaaaat 390421 aaaatgtcca gcgcagaaca agttcttgct tcacgtgagg tcccttcttt cgtaaaaatc 390481 agtcgattgt cattgtagca catctgacag aagggcggaa taggcgaaag gggctcaaca 390541 aaaaaacagg gccgccggag gcgccctgtt tcagcgtgtt ggcaaaccct tgcattcgtt 390601 gtcaggcctg tgcttcggtg ctcacgaatt taacattagc tgtgctccaa tgctcgccct 390661 tcctagactt caaaggtttt caatcacgct gaaaatcaca aaatcctaaa acgaatatcg 390721 ttttaggatt ttgtcaataa tctgaaacag ggcgctgacg ctctgttttt cttattacag 390781 cgggttcaaa atccggttta agaaccgctg tgtccgttct tcttttggtg cggagaaaat 390841 ttgctccggc ggtccctgct ccacgataac gccgccgtcg atgaagatga cttcatccgc 390901 aacctcctgc gcgaacttga tttcgtgggt cacgacgacc atggtccagc cttcattggc 390961 caagtccttg ataaccttca gcacctctcc gacaagctcg ggatcaagcg ctgaggtcgg 391021 ttcgtcaaac agcatgagct caggctgtat cgccagtgcg cgggcgatgc cgacgcgctg 391081 ctgctggccg ccggaaagct ggaacggata taaatccatt ttgtccttca atccgacttt 391141 atcaagaagc tgaatcgctt cttttctgac ttcctctttg ttccgttttt gcacctgaac 391201 agggccctcc atcacgtttt cgagggctgt gcggtgcggg aacaggtgat acgcctgaaa 391261 caccattccg gattttcggc gaagctttag gatatccgcc tgtttcacct ttttggagaa 391321 atcgatggag aaatcatcaa atgcaagctc tccgcgattc gggatctcca gagcgttcag 391381 gcagcggagc agcgtcgttt tccctgaacc tgaaggccca agtatggcga tgacttttcc 391441 tttttcaatc ttcatatcta tcttttttaa aatttcattt tcaccgaatg atttgtttaa 391501 tcctttaacg gtaagcatac tcggaacctc cttatttggc cacgtagcgg tcaagacgcc 391561 gttcgatgac atgctggacg agtgagagca ggaagcagat aatccaataa ataaaggctg 391621 cttcaatata gatcactaaa atttgatcaa gattccgcgc gccgatttcc tgggcttttc 391681 tgaacagctc agcgaccaga atttgagagg cgagggatgt atctttaatc aggctgataa 391741 aggtattgga taatggcggg atcgacacac gaaacgcctg cggcaaaatg acgcggaaca 391801 gcgttttttg atgtgtcatg ccaattgtgt agccggcttc ccattgccct ttcggcacgg 391861 ataaaataga tgcccgaatg atttcagatg cataggcgcc gacgtttaat gaaaaggcga 391921 taactgcgct tggaaatgga tctaatgtga cgttaaaggc cgggaacaga tagaaaatga 391981 tgaacaattg aacgagaaga ggagtgccgc gtattgcgga tacgtatacg ctgaacaccc 392041 atctcaaagg tctcactttc gacattctgg caagcgccgt aatcagcgcc aggatcattc 392101 cgaatataaa ggaaagaatc gtaaggggaa tcgtatagta gattccccct gaaagtatcg 392161 gccagaatga ctgctgcacc agatcccacg ggatcgccgt gccaagcgtc aatgccggca 392221 gattatttag aaacatcttc gccgaaccat tttttagaaa ttttagaaag agtcccgtcc 392281 tctttcattt cttttaatgc tttgttgact tgatcaacaa cctcgccgct tcctttacgg 392341 aacgtgaaat atgttgactg aggctcacct gtttcaaacg cgattttcac gtttttattg 392401 ccagatgttt ttaagtagtt caatacggca agcttatcgt tgtatgtcat atcgacgcgg 392461 ccttgctgga tcatttgaag ggcctgcgcc atgccttcaa cgccttctac tttagcgccg 392521 gcatttgtag ctaatttgtt gtagttgctt gtcagtgatt gagctgacgt ttttcctttt 392581 acatctgctt cagacttaat atcgttgttg tcttttttcg ttacgacaac ggctcttgat 392641 gttgtgtatt tatctgagaa atcatatttg tcttcacgat ctgtttttcc gacttggttg 392701 gcaacaacgt caaaccgttt ggaattcagg ccggcaaaca tactgtccca ttgtgtttcc 392761 ttaaagtcga ctttaagccc gaggcgtttt gcgacttctg tgataacttc gacatcatag 392821 ccagtcagtt tatcagtgtc tttgtcgtgg taagtgaacg gctcatatgt tccttccgtt 392881 ccgactgtga gcacaccttt tttcttaatt gaagcccaaa gatcgccatc tttggcatta 392941 tcttttgact gattgtcatt tcctgctccg caagctgcaa gagctgcaat acttacgacc 393001 atgaataaag ccaataatgc ttttttcatc ttattcccca cttttctggt tgattttatt 393061 gaaataaaaa attagcttac aaatctaaag gataactttt ttttagtatg agtcaagtat 393121 ttggttttca taagacaaaa tcttttaaaa taaatccaaa aattgctgtg ccggtttagg 393181 caaataactg tccgttctcc acatgacagc cggtgtcata atgaagggat tattttcgat 393241 atggacggtg tgaacgtgat ttctcatatg aacgggaatc attgtgacag gcaaaataga 393301 cgcgccgaat ccggatgaca cgaggctgag caaagttgca gagtcgtggc attcacaaac 393361 aatgcgcggc tccaggttca aacgatgaaa ttcattcatg acctgattat agacgccttt 393421 tccgttgaca ggccgcagca ggatcagcgg aaatgaagga atgtccacca tcttaatggt 393481 gtctccgcac ggatatccgg cttcatctga aagcacgagc acacatggaa tgtcatcaag 393541 ctgcttgaat tgtactgtgt cacttttgat cagtgttgtc gtgaccgccg catcgatttg 393601 ccggctttcc agcagttcca acagtgtcgc gggttcattt tcccaaatat taaaggtgag 393661 atgggggtat ctctctttga tctgtgttac tttttcaagc atcagagccg cgcaataaat 393721 cgttgatccc acggcaagtg taccggctac ttcctccttc agctcctgta cctcaatgac 393781 tgcatcttca aacctatgca gaatctcttt tgctcttttt agaaaaacag ctccttcata 393841 tgtaagagtc atttgttttt tcttgttacg gtcaaacaga acaacaccaa gttcgtcctc 393901 cagctgtttg agctgcctgc ttaaaggcgg ctgcgccatg tgaagctttt tggctgcgga 393961 cgtaattttc tgttcttggg caatggtaat gaagtatcga agctggcgaa tatccaaaag 394021 aaagcgcctc cttatcatac cttttaggta ttaattatag atttaataga tatttttcat 394081 atggatatat caggagtatg attgaaatga aagcagaatt caagcgtaaa ggagggggca 394141 aagtgaaact cgttgtcgga atgacagggg caacaggggc cattttcggg gtcaggctgc 394201 tgcagtggct gaaggccgcc ggagtggaaa cccatctcgt tgtgtctcct tgggcaaacg 394261 tcacgatcaa acacgaaaca ggctatacgt tacaagaagt agaacaactg gccacataca 394321 cttactcaca taaggatcag gcggcagcca tttcaagcgg gtcgtttgat accgatggaa 394381 tgattgttgc gccgtgcagc atgaaatctc tcgcaagcat tcgcacagga atggcggata 394441 atctgctgac acgtgcggcg gatgtcatgc tcaaggagag aaaaaaactc gtcctcttaa 394501 cgagagagac gcctttgaac caaattcatc tcgaaaatat gctagcgctt acgaaaatgg 394561 gcaccatcat tcttcctccg atgccggcat tttataatcg gccgagaagc ttagaggaaa 394621 tggttgacca tattgttttt agaacgttgg accaattcgg cattcggctt cctgaagcga 394681 agcgctggaa tgggattgaa aaacaaaaag gaggagcttg atcatggctt atcaagattt 394741 cagagaattt ctcgctgccc ttgaaaaaga aggacagctg cttacagtga atgaagaggt 394801 aaagccggaa ccggatttag gggcctccgc acgggcagcc agcaatcttg gcgataaaag 394861 ccctgcgctc ttatttaaca acatttacgg ctatcataac gcgcgaattg cgatgaatgt 394921 catcggctct tggccaaacc atgccatgat gctgggcatg ccgaaagaca caccggtaaa 394981 agaacagttt tttgaattcg caaagcgtta tgaccagttt ccgatgccgg tcaaacgtga 395041 ggaaacagcg ccatttcatg aaaatgaaat cacagaagat atcaatttgt tcgatatact 395101 gcctcttttc agaattaacc agggtgatgg aggctactat ttagacaaag catgtgtcat 395161 ttcccgtgat cttgaggacc ctgacaactt cggcaaacaa aatgtcggca tttacagaat 395221 gcaagtcaaa ggaaaagacc gccttggcat tcagcctgtc ccgcagcacg atattgcaat 395281 ccatctgcgc caagctgaag aacgcggcat caaccttccg gtcactattg cgctcggctg 395341 tgagccggtc attacaacgg cggcatcgac tccgcttctc tatgatcaat cagaatacga 395401 aatggcaggt gcgattcaag gcgaaccata tcgcatcgtc aaatcaaagc tgtctgatct 395461 tgatgttccg tggggcgctg aagtggtgct tgaaggtgag attattgccg gagagcgcga 395521 atatgaaggg ccgttcggtg aattcacagg ccattattcc ggcggacgca gcatgccgat 395581 tatcaaaatt aaacgcgtct atcacagaaa caatccgatc tttgaacatt tatacttagg 395641 catgccttgg acagaatgcg attacatgat cggcattaac acatgcgtgc cgctttatca 395701 gcagttaaaa gaagcgtatc cgaacgaaat tgtggcagtg aacgccatgt acacacacgg 395761 tttaatcgcg attgtttcca caaaaacccg ctatggcgga tttgcgaaag cggtcggcat 395821 gcgcgcactc acaacgccgc acggactcgg ctactgcaaa atggtcatag tcgttgatga 395881 ggatgtcgat ccattcaacc ttccgcaggt catgtgggcg ctttcgacca aaatgcatcc 395941 gaaacatgat gcggtcatca ttccggactt atctgtcctg ccgcttgatc cgggatccaa 396001 tccatcagga atcactcaca aaatgattct cgacgccact acaccggttg cgccggaaac 396061 aagaggccat tattcacagc cgcttgattc tccgctaaca acgaaagaat gggaacaaaa 396121 actaatggac ttaatgaata aataaggaaa ggatgttcga aatgcataca tgtcctcgat 396181 gcgactcaaa aaagggagaa gtcatgagca aatcgcctgt agaaggcgca tgggaagttt 396241 atcagtgcca aacatgcttt tttacatgga gatcctgtga accggaaagc attacaaatc 396301 ccgaaaaata caatccagcg tttaaaattg atccaaagga aacagaaaca gcaattgaag 396361 ttccggcggt gccggaacga aaggcttgat ccgcgtgaac tgtatgtcag accgtctctt 396421 tgagctgctt gacgggagct gcctgaatga gaagcagcat gaggccttcg ttctgcaaac 396481 agtatcagag gatggctggc cgcatgccgc tatgatcagt gcaggtgaaa tcatcgcgct 396541 gagccgaact gatatccgaa tcgctctgtg gaaaaacaca atgacttcgg ccaacatcct 396601 tcgcacagga aaagcacagt tcacggcgtg gtggaaggga gcggcctatt atgtaaagct 396661 tgaatgcgcg cctttaccgc ctttgaaaga tgccgaatat gaaagagacc gtttttcctg 396721 ccgcatcgtt tcagtgaaag aggacgttgc gaaatacgct gatttgactt caggtgtccg 396781 tatacagctt cacagccctg aagaggtgct gagcagatgg aaaaagaccc tggaagattt 396841 aaaacggtaa tatcgatagc ctgacgccat gcgtcaggct ttttttatat aatgaaaaca 396901 aaagggggcg tgagaaatgg aacgtgcggg gatctgtcac tcggacggct ttgatttagc 396961 ttatcgaatt gagggcgagg gcgcacccat ccttgtgatc gggagtgcgg tttactatcc 397021 gcgccttttt tcctcagata tcaaacagaa atatcaatgg gtctttgtcg accatagggg 397081 atttgctaag cctaagcggg agcttcgtgc ggaggattcg aggcttgatg ctgtcttggc 397141 tgatatcgaa aggatgagaa catttcttca gcttgaggat gttactatcc tgggacattc 397201 cgggcacgct tttatggctt tagagtatgc caggacatat cccaaacaag ttcggaaggt 397261 ggcgctcttt aatactgcgc ctgataacag tgaagaaaga cagcgaaaaa gcgaatcatt 397321 tttcatggaa acagccagtc ttgagagaaa gaaacgcttt gaaaaagaca tcgagaattt 397381 gccgcaggac atcgacaaag atcctgaaag gcgctttgtg cacatgtgta ttcgcgctga 397441 agcgaaaagc ttttatcaag agcggccgca tgctgctgcc ttatgggacg gtgtattcac 397501 gaatatgccg atcattgatg aattatgggg caatacattt gcccggattg atcttcttca 397561 gcggttagct gatgttcgta tgccggtgta tatcggatta gggagatatg attatttggt 397621 tgcgcccgtt tcgctatggg atgctgttga cggtttatat ccccatgttg ataaggttat 397681 ttttgaaaag agcggccatc agccgatgct ggaagaaccg gaagcctttg atcaaagctt 397741 caggaaatgg cttgatcaat aaaaaacagc ccgcagatca acatccgcgg gctgtttctg 397801 attataagac ccctttcatc gcgcgtttga tcaccggcga gagcagcagg agaatgccgc 397861 caagaacgat agaaatcaaa ccgatggtgc cgaagtacat tgtttcagga attttatcaa 397921 acaatccggc tacttgggca ttgatcgctt gggctgctgc gttcgtcaga aaccacatac 397981 tcattgtctg tgcagagaag gcagctggtg ccagtttcgt tgtcacggat aaaccgactg 398041 gagacaggca cagctctcca agcacgacaa gcaggaagct gagaacgagc caaagcgggc 398101 ttacgagtgc ttcttttcct tgcatagcag ggaataccat aatgataaat gacaatccgg 398161 ctaaaataat tccgattgag aatttaactg gtgtagacgg ctgacgtttg ccaagcttca 398221 tccagagcca tgcgaatatt ggcgcaaaaa tgacaacaaa caatggattt aatgattgga 398281 accatgatga ctgaagttcg aatccgccca atgaaagtct tatgcgttca tcagcgtata 398341 ccgcaagaat ggtcgctccc tgttcctgaa tggcccagaa catgacagca ccgataaaca 398401 aaggaacgta agcggcaaga cgggattttt ctgttttgtc cgcttttttg cttgtaaaca 398461 tgatgatgaa ataaatcaca ggaatcaaaa taccgagaat acttacaagg tcaatgaaac 398521 gtttgatcgt cagcacgcct gtttgtacag agataatcac tgcgatcgcc acaatgataa 398581 caccgattcc ggtgccaatt gcagattttt tagacagcgg attcggcaca ttggaacctg 398641 caagcccgag gtttttcttt cttgtcaaag caaatacgat aagtccgaga agcattccga 398701 ccgcggcagc tccgaatccg agatgatagt tgtacttctg tccgagtgtt ccgacaatta 398761 acggcgcgag taaaccaccg aggttaatcc ccatgtagaa aatactgaaa cctgagtcgc 398821 ggcgcgggtc ttctttcgtg taaagatccc caactacgct tgaaacgttt ggttttaata 398881 agcctgttcc gacaatgata agcaccatac tgatatagaa tgctatcgaa ctgcccggat 398941 aggcgagtgc aatgtggccg aacataatga atatgccgcc gtaaaacacg gtgtttgcgg 399001 taccgaatac ccggtcagcg agccatccgc caataatggt ggacatgtat acgagtgatc 399061 cgtaaatcga cataatggca accgcagtgc ccttgtcaaa gccgagccct ccgtttaccg 399121 tctctgtata caaatagtaa agtaagattg ctctcattcc atagtaagag aaacgctccc 399181 aaaattcggt gaaaaatagt gtaaatagtc ctcgcgggtg accaaagaac cctttttgcg 399241 ggacgctttt aatgatactt tcgttatcaa tcgaagccat gtcagccaaa ccctttctaa 399301 aaaaagtgta ttataaaaat catattctta tataatactt gtgtcaatat aatttatact 399361 catttcaaat agttccatat tggaaaaatt ataaatacct aaaaatagtg atttcctcct 399421 aatttttaaa ctttttatcg tgagattttc ttacacaact attcctttat atttttttaa 399481 taaaatttta gagaaatgta caagcagatc gggaggaccg ctggtgaatc aatcccctgt 399541 aacggggatt tttttatgtc cgtaaaccgc tttgaaaagc cgctgcacac cctcctgaat 399601 atcttcttcc ttcagccgtg caaagccgat aatgagagca ggcctgcccg tttgccgctt 399661 gttttccttc aagttaaatc ggctcattcc gaatatttca agctgcagcc cggcagcatg 399721 tgacaggatg tcttgttcgg tgcgcctggt atcaaattcg gtaacaaaat gcagccccgc 399781 atttgcccct tttacggtaa cctctccgct gaactctgct tctaaagcgg tgatcaggcg 399841 ttctctcttt tctttataat gctgcttcat tttttttata tgcttctgat attcaccaga 399901 ctcgataaat tcctgcaggg tgagctgtgt gagtgatgag caagtctgca gatcatagcc 399961 ccgctgtttg tatgccctca acagctcagg cggcaacacc atatagctga tccgtaagcc 400021 ggggagaagg gactttgaaa aggttcccat atagatgaca ttttgaaaac ggtcgaggct 400081 ttgcagcgcc ggaatactgt ctacatcata tgtgaattca ctatcataat cgtcctcaat 400141 gatatatcgg cgcggctcct cggctgccca gttcagcagc tgaattcttc tggatacagg 400201 cataatcgtt ccggacggaa actgatgcga cggggtggtc accagcacat ctggctgctg 400261 tctggtgatt tcagcaatcg acatgccttt ttcatccagc atgatcgtct ttacttgttt 400321 tccggcattc ttcaaaagct gatacatgcg cctgtagcca ggctcctcca tcgcatacac 400381 ggcttccttg ggtaaaagct cagtcaacag ctgcatgagc acctgtgtgc ctgcccctat 400441 gatcatttgt tccggcctgc attttacacc cctcgtcagg gaaatgagcc tcgtaatggc 400501 cgctctcact tcatatatcc cttgcggatg tgacatatcg ccgagcgtgc ggtatgagcg 400561 ggaggccgct ttttgctcgc agcggaacca gcttttgatc ggaaaatggt ctgtatcgga 400621 actcatgtgt gaaaacgata tccaatcgct ctggtcgatg tgaatctctt ttaggtcatc 400681 cggcagtgca aatggagggt gctcctcggc ggaaaacatg tctagttcct ccacgaagaa 400741 accctttcgt tcaatggcgt acaaataccc ctcagccagc agctgctgat aggctgaatt 400801 cactgaattt acgctgacct tgagattttc agccagctcc cgcttggagg gaaccttcga 400861 gtgcggcagc agattgcggc tgaggatttc ttttttcagc ttttgataaa tttgctgata 400921 gatataatcg gcttgttctg aacgatcgag tgtaatcgtg atatccattt tgtagtttct 400981 ccttctgata ccatcaaaaa gttataattg gtacttttca tcataccaaa gagaagtcag 401041 aatgataaga aaataccgac agggggatat tcacatgagt caaacaacag caagcatcac 401101 aactgcacaa tggcagcaaa aacgggatca atttgtgtca aaaggtgtga gcaacggcaa 401161 ccgcagtctg gcggtcaaag gagaaggggc cgagctgtac gatctggatg gccggagatt 401221 tattgatttt gcaggcgcca tcggcacgtt aaatgtcgga cactcgcatc cgaaggtggt 401281 tgaggctgtg aagcggcagg cggaggagct gattcatcct ggttttaatg tcatgatgta 401341 cccgacttat atcgaattag cagaaaaact gtgcggcatc gcgccgggca gccatgagaa 401401 aaaagcgatt tttcttaact caggggcaga agcggtcgaa aacgctgtga aaatcgccag 401461 aaagtataca aagcgccaag gcgttgtctc gtttacacgc gggtttcacg ggcgcacgaa 401521 tatgacgatg agcatgacaa gcaaggtaaa accttataaa ttcggtttcg ggccttttgc 401581 gccagaggtt tatcaagcgc cgttccctta ttattatcag aagccggccg gcatgagtga 401641 tgaaagctat gacgatatgg tcattcaagc attcaatgat ttctttatcg cttcagtggc 401701 gcctgaaacg gtggcgtgtg tcgtgatgga gccagtgcag ggagaaggcg gatttattat 401761 tccttcgaaa cggttcgtac agcacgtcgc ttcattctgc aaagaacacg gcattgtttt 401821 tgttgctgat gaaatccaaa ccggctttgc cagaactggc acttatttcg caattgagca 401881 ctttgatgta gtgcccgatc tgatcacggt ttctaaatcg cttgcggcag gcctgccatt 401941 aagcggtgtg atcgggcgtg cggaaatgct tgatgcggca gcgccagggg agctgggcgg 402001 cacgtatgcc ggcagcccgc tcggctgcgc ggcggctttg gcagtcttgg atattatcga 402061 agaagaagga ctgaatgagc gatctgaaga aattggcaaa atcattgaag acaaggcgta 402121 tgagtggaaa caagaattcc cgttcatcgg tgacatccgc agactcgggg cgatggccgc 402181 aatcgaaatc gtcaaggatc ctgacacgcg tgagcctgat aagacaaaag cagcagcgat 402241 cgcggcctat gcgaatcaaa acggattact tttgctgaca gcgggaatta acggtaatat 402301 catccgcttt ttgacaccgc tcgtcatctc agacagccta ttaaatgaag ggctcagcat 402361 cttggaggcg ggcctgcgag cttaatcatt ggaaagaaaa tggccgggtc tgctatcatt 402421 ttaagtaatc atgaaaagaa aggaatgttc aatatgccag atcaattaac ggtctacaac 402481 ccggctacgg gcgaggagat caaaacgatt cctcagcaat cagccacaga ggtagaagaa 402541 gccattgaac gttcacatca agcgtttaaa acgtggtcta aaacatcagc gaacgaaaga 402601 acgtctcttt tgaaaaaatg gtatgagctg attgttgaac ataaagaaga gcttgcagat 402661 ttaattacaa aggaaaacgg aaaaccatac caggaagcag tcggcgaggt actttacggc 402721 gcaggctata tcgaatggtt cgcagaggaa gcgaagcgtg tgtacggaag aacggtcccg 402781 gccccgacaa ctggtaaacg aattgttgtc acacgccagc cggtcggccc cgttgctgct 402841 atcacgccct ggaatttccc gaatgcgatg attacacgca aagcggcgcc tgctcttgcc 402901 gccggctgta catttatcat caagccggcg ccggacacac cgctgtctgc ttatgaacta 402961 gcgcgcctcg catatgaagc gggcattccg aaggatgttc ttcaggttgt gatcggcgat 403021 ggagaagaaa tcggaaatgt gttcacaagc agtccgaaaa tccgcaaaat cacgttcaca 403081 ggctcaacac ctgtagggaa aatccttatg aaaaacagcg ctgacaccgt aaagcacgtc 403141 tcaatggagc tcggcggaca cgccccgctg atcgtagatg aagatgcgga cattgacctt 403201 gccgttgaac aggcgatggc gtccaaatac cgaaacgccg gccaaacctg cgtatgtgcc 403261 aaccgcctga tcgttcatga atccattaaa gatgaatttg ctgcgaaact gagcgagcaa 403321 gtgtctaagc tgaaagtcgg aaatggactt gaggaaggcg tcaatgtcgg cccgattatc 403381 aacaaacgag gcttcgaaaa aatcgtcagc caaatagatg atgcggttga aaaaggcgcg 403441 aaagtgattg ctgggggcac atatgaccga aacgatgaca aagggtgcta ctttgtgaat 403501 ccgacagtgc tcaccgatgt cgatacgtcc atgaacatca tgcatgagga aacattcggc 403561 ccggtcgccc cgatcgtcac gttttctgat attgatgaag cgattcagct tgccaacgat 403621 acaccgtatg gcttggctgc ttacttcttc acagaaaact accgccgcgg catctatatt 403681 tccgagaatc tagagtatgg cattatcggc tggaatgacg gcggaccgtc agcggttcaa 403741 gcgccattcg gcggaatgaa agaaagcggc atcggccgtg aaggcggttc agaaggtatc 403801 gagccgtacc ttgaaacaaa atatttgtcc atcggtttat aaaagaatgc acgctcctga 403861 gagctgccgg attttccggc agctcttttt gtgttccggc gaataatcac aacaattcca 403921 gccaaaataa cagcaaatac attttgaaag aaggttcccc aacaatggat ttattattgg 403981 ctcttctccc ggctttgttt tgggggagca ttgttctctt caatgtgaaa ttaggcggcg 404041 ggccgtacag ccagacactg ggaacgacga tcggggcact cattgtttct atcgttattt 404101 acttttttgt tcagcccgtt ctgtcccttc gcatttttat tgttggaatc gtatccggct 404161 tattttggtc acttggacag gccaaccagt tgaaaagcat tcaattgatg ggcgtgtcga 404221 aaacaatgcc gatttccaca ggaatgcagc tcgtttccac ctcgctgttc ggtgtgatcg 404281 tgttccgcga atggtcaaca ccgattgcga ttacgcttgg cgttctcgct ttgatcttta 404341 tcattgtggg aatcattctc acgtccttgg aagataagaa tgataaaaaa gagggcgagc 404401 caagcaattt gaaaaagggc attttgattc tccttgtttc gactcttggt tatttggttt 404461 atgtagtcgt ggctagatta ttcaatgtgt ccggctggtc cgcgctgctg ccacaggcaa 404521 ttggcatggt ggtcgggggg ttagttttaa cctatagaca caaacccttt aacaagtatg 404581 cgatcagaaa tattctccca gggttaatct gggcaggcgg aaatatgttt ttgtttattt 404641 ctcagccgcg agtcggcgtt gcaacgagct tttccctttc acaaatggga attgtcattt 404701 ctacgctcgg cggtattttc atcctgcgtg aaaagaaaac gaaacgccag ctaatagcaa 404761 ttgcgatcgg gattatcctg attattgccg ccgccgtatt cttaggaatc gccaaaacaa 404821 attcataaca aatggaggag gatgtatatg tatccggatt taaaaggaaa agtcgtcgct 404881 attacaggag ctgcttcagg gctcggaaag gcgatggcca ttcgcttcgg caaggagcag 404941 gcaaaagtgg ttatcaacta ttatagtaat aaacaagatc cgaacgaggt aaaagaagag 405001 gtcatcaagg cgggcggtga agctgttgtc gtccaaggag atgtcacgaa agaggaagat 405061 gtaaaaaata tcgtgcaaac ggcaattaag gagttcggca cactcgatat tatgattaat 405121 aatgccggtc ttgaaaatcc tgtgccatct cacgaaatgc cgctcaagga ttgggataaa 405181 gtcatcggca cgaacttaac gggtgccttt ttaggaagcc gtgaagcgat taaatatttc 405241 gtagaaaacg atatcaaggg aaatgtcatt aacatgtcca gtgtgcacga agtgattcct 405301 tggccgttat ttgtccacta tgcggcaagt aaaggcggga taaagctgat gacagaaaca 405361 ttagcgttgg aatacgcgcc gaagggcatt cgcgtcaata atattgggcc aggtgcgatc 405421 aacacgccaa tcaatgctga aaaattcgct gaccctaaac agaaagctga tgtagaaagc 405481 atgattccaa tgggatatat cggcgaaccg gaggagatcg ccgcagtagc agcctggctt 405541 gcttcgaagg aagccagcta cgtcacaggc atcacgttat tcgcggacgg cggtatgaca 405601 caatatcctt cattccaggc aggccgcggt taaacataaa aagcgaccca gacatgacat 405661 ctggatcgct ttctttatta ggcacgcttt ttctttacaa gtgctgctac agataaaata 405721 atggcagccg cagacagcac catcgctgta atgtctagag ctgaagaacc tgagttttcg 405781 gaatcgtctt ctgttttcgt ggcgccgtgc tcatctgtca cttgctttgc agacgtgatg 405841 tttgtaatgg aatgaggtgt atcggcatcc tcgtcacctg tccactcaac aatgctgccg 405901 tctttgtaat attggtatgc gtcccaagca gcttcctccg ctttgtcagg gtttttggca 405961 acaaaggtaa actgctggaa ctggccttcc tgaatgcctc cgtcagtcgc ctcccatgtc 406021 acggatactg atttgtcatc atgtttttga gtggaaacct tccagcccgg aattggctca 406081 tattgctgga attcaacatc cttcggcatt ttgaggacaa ccttcgttgt cggcagattt 406141 ttctcagaag gaaccttcat tgtatacgtt tcccaagagc ctgcagcaga ctcagccggt 406201 tttacagaaa catgcgcgct ggcaggggcc gtaaagaata agagggagcc gacaatagcc 406261 ggacatagtg tcaatgcgat ttttttcaac aacgtaaaca ctccttaatt ggtctttgta 406321 aacatgatat tgatttcgtt aaagtcgccg gtcaggccgt ggactttgat cttccagttt 406381 cctttttcat taatcgacag gttttgatct tggaagacgc cttttgtttt ttcttttaat 406441 gtaaaggtgc ttttgttttc gctgcctgac aggcctgttt tataaacggt taacgtgatt 406501 tgctggatgt ttttcacggg atcaccgtta tggtcggtga cccgcagctc aaaaacattt 406561 tttccaggct ggtttgggct gatgctgaga gaaacgcttt gtccgttctc tatcgctttg 406621 gtttggtaga acggttccgg cgctggctca ggcgggcttg gcaggcttgt aaacacggcc 406681 gctgtgatca atacagcgat gccgattgcc cactccgctt tcaacgttcg gctgattcct 406741 gtgcggcgct gctttctggt aagcagaaaa tgaattgcgc ctaagaccag catgaaaaca 406801 aacagcccgc ttttcactaa aagagcttgt ccgtacgctg tatggaacag tgaatccatt 406861 gaacgaatga tgaaaaatcc attgagcaag cctgaaaaca aaatgacgcc gactgcagtg 406921 agcgcccatg gggagaaccg tctgaccgtc tcccacgcga gcgttttgtc aggctgcctc 406981 cattcttttg agagcagcaa aacgagtgcc gctattccgc cgacccagat ggaagcggaa 407041 gttaaatgaa ggaaatccat caaaatgccg accgtttttt cttcaacgac agcagcatgc 407101 ccggtaaacg ccttggcaag caggagaccg aaaaagaaaa tgagcggcgc tgtccaatag 407161 ccaaaggatg aaaagcggtt tttccgtatc gcagggatga cagacagtgc gagcagcacg 407221 aacagcgcag cctgtatgat ccaaatggag ccgcctgctg tctcaaacag tgtttctctg 407281 atgtagcccg gctggaatgc gctgccccag ccgccgcctg cgttcgcttt tgtctgaatc 407341 ggaagctgaa gcaaaagcgc cagccccaat gctgcgatcg agccggtcag gatacgtctc 407401 gtccgtttga cgagctgttc tgatttccct ttataccaga aaagatggaa gaaaaccgtt 407461 ccgataaaca gagataaggc tgtatacaga atcgcgcgat ctgctgctgt tcccggattc 407521 agcgctgaat cggctgcttt ttggctgctg aatccgccat ccgctttccc gatactgaac 407581 ggaatgacgc cggaaacagg atgtccatcc gcggatacgg cattccattc cgctctgtac 407641 acatctttag gcagattctt cttcagcttc actgtcatga tgtgatgatt atcttttttg 407701 atttcagtct tgtccgtatc cacacggtcg ccgtttgaat tatagacttt aatgtaatga 407761 aacccttctt caaccggttc attaaattcg atttccacct gcgcaggggc gctttttaat 407821 tcgctgtttt ccccaggtga agatttgaca atataggcgt gagcaaagct tgttttcggc 407881 aggaaaacaa gaaaaagcag aaggatgatc caccatctgt ttcgcttcat cactcagaca 407941 ccaccttccg ctgtatgtgt tgtgttattt cttggtgcag gtgcagcgtt tctttcggtc 408001 ttgaagcatg tcttccagcg cttggtcgaa agtgcagacg gctccgccga atcctttttg 408061 aaatcgttcg gcatggtcaa gtgtcgcaaa cggaatggcc tgcggctggc agcagtgcag 408121 gtttaattca gcatttacga cgaaataagc cgaaccggca ctgacggttg tctgtaacag 408181 aaaatctctg caaatcaagt gtgaaacctc ttccgtttta tccgcgtaac gcaaaaacgc 408241 gcaatgtgcg cagcatagct gttcaatgtc ttggtttacc gtaatcagct gaaccgaatg 408301 agcttgattg acgggcttca agcaatagct gcacatatga tctgtttgag gtgttcggac 408361 ggggagcgtg atgccgccgg ccgttttaat gacctgattt gactgaacca gctgattgac 408421 atctctatat accgtcattt ccgaaacgcc gaaccttgcg ctgatgtcag aaattctaag 408481 cgagccttct tctttcagcc acttcagtat gtgttgctgt ctattaatcg gaagcattca 408541 tacaccctct tcattaagat ctatttaagc gtagaggatt ttagagacgg agacaagtaa 408601 gtggatgata aaaaatgtga aaatgtgttg aacagcaaca aaacgaaaca gaagggactc 408661 tggtataata gacagatgga atagaaagtg aggaataccc tatgaaagaa acaccatgcc 408721 cgaactgcgg caaacctttg acaggcgata tggtcagatc atcaaatgtg ccttgtcaat 408781 ttcgctgcgg ccactgccgg gaacggcttt atgaatataa agtttcagct ccgattatgc 408841 tggtatcatt agcggccatc gtgctgctta tttatctttt gatgctcctc cgcaatgcgg 408901 caggctcagt gctgccagct gtacagcacg tgccgatggc tgtatttgcg cttgtgtgcg 408961 cgtatcccgt ttttattgtg agtgagcgga tgattgcaaa gtacgtgatt caaaatggca 409021 acatcattta tagaggaaag agaaaaggct cctgaaacca ggagcctttt tatttttaaa 409081 aaattgtcac agtcatgtgc caaagtcctc tttactttca attgtatagg gactgtaagc 409141 gttttaacat agagtcaaag ggaagcatca ttctctgaac atatttttgt atcttacagc 409201 gacaaacaaa acagggaggg tttatatatg cagcagcaag aacagcagca aggcggcatg 409261 aaagtgaaag tgcaacgctt tgggagttat ttgagcggaa tgatcatgcc gaatatcggc 409321 gcgtttatcg cgtggggtat cattaccgcg ctgtttattc cggcaggatg gtttccgaat 409381 gaacagctga acacgctggt cagcccgatg attacgtatt tattgccgct tttgatagcg 409441 tatacaggcg gaaaaatgat ctacgaccac cgcggcggag ttgtcggagc gacagcggca 409501 attggggtga ttgtaggatc ggatattcca atgtttttag gcgcaatgat tatgggtccg 409561 cttggcggat acctcattaa acagactgat aaattattca aggataaagt caagcaaggc 409621 tttgaaatgc tgatcaacaa ctttacggca gggattgtcg gcgcggcttt aacgattctc 409681 gcgttttacg ccatcggccc ggttgtcttg acgctaaata aattgctggc ggctggtgtg 409741 gaagtcattg tacacgctaa tttactgccg gtagccagtg tttttgtaga accggcgaaa 409801 gtgttgttcc ttaacaacgc cataaaccat ggaatcttaa gcccgatcgg aatcgagcaa 409861 gcatctcaaa caggaaaatc aattctgttt ttagtagaag caaaccctgg accggggctc 409921 ggcattttgc tggcctacat gttctttggc aaaggatctt caaaatcaac ggctcccggt 409981 gcggcgatca tccatttctt cggagggatt cacgagattt acttcccgta cattctgatg 410041 aaaccggccc tgattctcgc agccattgcc ggcggagcaa gcggactctt aacatttacg 410101 atctttaatg ccggacttgt cgcggcagcg tcaccgggaa gcattatcgc attgatggca 410161 atgacgccaa gaggaggcta tttcggcgta ttggcgggtg tattggtcgc tgcagctgta 410221 tcgttcatcg tttcagcagt gatcctgaaa tcctctaaag ctagtgaaga agacctggct 410281 gccgcaacag aaaaaatgca gtccatgaag gggaagaaaa gccaagcagc agctgcttta 410341 gaggcggaac aagccaaagc agaagaagcg tctgagctgt ctcctgaaag cgtgaacaaa 410401 attatctttg cgtgtgatgc gggaatggga tcaagtgcca tgggggcatc catcttaaga 410461 aacaaagtga aaaaagcgga gcttgacatc agtgtgacca acacggccat taacaatctg 410521 ccaagcgatg cggatattgt catcacccac aaagatttaa cagaccgcgc gaaagcaaag 410581 ctgccgaacg cgacgcacat atcagtggat aacttcttaa acagcccgaa atacgacgag 410641 ctgattgaaa agctgaaaaa gtaatcttat agaaagagag tgattgtcat gcaagtactc 410701 gcaaaggaaa acattaaact caatcaaacg gtatcatcaa aagaagaggc tatcaaattg 410761 gcaggccaga cgctgattga caacggctac gtgacagagg attacattag caaaatgttt 410821 gaacgtgaag aaacgtcttc tacgtttatg gggaatttca ttgccattcc acacggcaca 410881 gaagaagcga aaagcgaggt gcttcactca ggaatttcaa tcatacagat tccagagggc 410941 gttgagtacg gagaaggcaa cacggcaaaa gtggtattcg gcattgcggg taaaaataat 411001 gagcatttag acattttgtc taacatcgcc attatctgtt cagaagaaga aaacattgaa 411061 cgcctgatct ccgctaaaag cgaagaagat ttgatcgcca ttttcaacga ggtgaactga 411121 catgatcgcc ttacatttcg gtgcgggaaa tatcgggaga ggatttatcg gcgcgctgct 411181 tcaccactcc ggctatgatg tggtgtttgc ggatgtgaac gaaacgatgg tcagcctcct 411241 caatgaaaaa aaagaataca cagtggaact ggcggaagag ggacgttcat cggagatcat 411301 tggcccggtg agcgctatta acagcggcag tcagaccgag gagctgtacc ggctgatgaa 411361 tgaggcggcg ctcatcacaa cagctgtcgg cccgaatgtg ctgaagctga ttgccccgtc 411421 tatcgcagaa ggtttaagac gaagaaatac tgcaaacaca ctgaatatca ttgcctgcga 411481 aaatatgatt ggcggaagca gcttcttaaa gaaagaaata tacagccatt taacggaagc 411541 agagcagaaa tccgtcagtg aaacggtagg ttttccgaat tctgccgttg accggatcgt 411601 cccgattcag catcatgaag acccgctgaa agtatcggtt gaaccatttt tcgaatgggt 411661 cattgatgaa tcaggcttta aagggaaaac accagtcata aacggcgcac tgtttgttga 411721 tgatttaacg ccgtacatcg aacggaagct gtttacggtc aataccggac acgcggtcac 411781 agcgtatgtc ggctatcagc gcggactcaa aacggtcaaa gaagcaattg atcatccgga 411841 aatccgccgt gttgttcatt cggcgctgct tgaaactggt gactatctcg tcaaatcgta 411901 tggctttaag caaactgaac acgaacaata tatcaaaaaa atcatcggtc gctttgaaaa 411961 tcctttcatt tcggacgatg tgacccgcgt agcgaggtca cctctcagaa aactgggaga 412021 aaatgataga cttgtaggcc cggcaaagaa aataaaagaa ccgaatgcac tggctgaagg 412081 aattgccgca gcactgcgct tcgatttcac cggtgaccct gaagcggttg aactgcaagc 412141 gctgatcgaa gaaaaaggat acagcggcgt acttcaagag gtgtgcggca ttcagtccca 412201 tgaaccgttg cacgccatca ttttaaagaa acttaatcaa taaccgacca cccgtgacac 412261 aatgtcacgg gcttttttta ctatctcgca atctagtata atagaaagcg cttacgataa 412321 caggggaagg agaatgacga tgaaacaatt tgagattgcg gcaataccgg gagacggagt 412381 aggaaaagag gttgtagcgg ctgctgagaa agtgcttcat acagcggctg aggtacacgg 412441 aggtttgtca ttctcattca cagcttttcc atggagctgt gattattact tggagcacgg 412501 caaaatgatg cccgaagatg gaatacatac gcttactcaa tttgaagcag tttttttggg 412561 agctgtcgga aatccgaagc tggttcccga tcatatatcg ttatgggggc tgctgctgaa 412621 aatccggagg gagcttgagc tttccattaa tatgagaccc gccaaacaaa tggcaggcat 412681 tacgtcgccg cttctgcatc caaatgattt tgacttcgtg gtgattcgcg agaacagtga 412741 aggtgaatac agtgaagttg gcgggcgcat tcacagaggc gatgatgaaa tcgccatcca 412801 gaatgccgtg tttacgagaa aagcgacaga acgtgtcatg cgctttgcct tcgaattggc 412861 gaaaaaacgg cgcagccatg tgacaagcgc cacaaagtct aacggcattt atcacgcgat 412921 gccgttttgg gatgaagtct ttcagcagac agccgctgat tatagcggaa tcgaaacatc 412981 atctcagcat attgatgcgc tggccgcttt ttttgtgacg cgtccggaaa cgtttgatgt 413041 cattgtggcg agcaacttgt tcggtgatat tttaaccgac atcagctcaa gcctgatggg 413101 aagcatcggc attgcgcctt ctgcgaacat caatccatcc ggcaaatatc cgtccatgtt 413161 tgaaccggtt cacggctcag ctcctgacat tgccggacag ggccttgcca atccgatcgg 413221 ccagatttgg acagcgaagc tgatgctcga ccacttcgga gaggaagaat tgggggcgaa 413281 aattctggat gtaatggagc aagtgactgc cgacggcatc aaaacacgcg acattggggg 413341 acaaagcaca acggctgagg tcactgatga aatctgttcg cgcttaagaa agctctgatg 413401 aatcaggccg gtggcagatg gctgccccgg cctgtccatt tccttacgaa aatttccacg 413461 aaagtctaac caagcagatc caaatgctgt ataataattt ggaattctta ggaaagcatc 413521 gggtgaagga agttgaatgc aaaaacaatc acgttaaaga aaaaaagaaa aatcaaaacg 413581 atcgttgtac tcagtatcat tatgatcgca gctctcattt ttacgatcag attggtgttt 413641 tacaagcctt ttcttattga aggatcatca atggccccaa cgcttaaaga ctcagaaaga 413701 attctggttg ataaagcagt caaatggact ggcgggtttc acagaggaga catcatagtc 413761 attcatgaca aaaagagcgg ccgctcattt gtcaaacgtt taatcggttt gcctggtgac 413821 agcattaaaa tgaaaaatga tcagctatac ataaatgata aaaaggtgga agaaccatac 413881 ttaaaggaat ataaacagga ggtcaaagag tcgggtgtaa ccttaacagg tgacttcgaa 413941 gttgaggttc cttccggtaa atattttgtg atgggagata accgtctcaa ttcactggat 414001 agcagaaacg gaatgggcat gccttctgag gacgatatca tcggtactga atctctcgtc 414061 ttttatccat tcggtgagat gagacaggca aaataaaatg caatgcaaaa agaacatgga 414121 acatgacggc accgataata aagcgccgtg cacgtttaaa aaaatgatga tgaaacggtg 414181 cggagccggc tttccgcccc gttttttatg atagaaagcg ttttgaagaa aagggccctg 414241 ttgaaataaa cagaatcagg attggcgaag ccgtgaagcg catcgaattg gtaaatctca 414301 agatgggtat gctgtttttc ccgcagtttt ttgataagaa gcgctacgtc aaacgacggc 414361 tcataattag ggaaaaacaa taggaccggg caggctggca tgtgatgaag agagtcgcgt 414421 atccgggaac cgtaataaca aaccgatccg ctcacctcag gcatactgct gcatttccat 414481 gcgatagtag cccccacgct gaatccaatc acaaagatgt gccgtccggc gttttgcctg 414541 atcacattct ggatgatggt ttctcccgtt ttcagccttt cgtgttttgt aaattgttcg 414601 tatgccgttt tttcttcttt cagtgtgtag acttcatcct cgccgagcag gttgggcgtc 414661 aacacatcat atccagccat tttgatcagc cggcccatct ttttcatatg gctgtttaca 414721 ccatatattt cgtgtgcgag aatgacaagc ggttttggga acataacggc ctccttttgt 414781 gttttttcca ttatatccta tcgtttcact ttaggctgag atataatggt caaaaaaagg 414841 agatataaaa tgaactcatt atctttgcct caccgctatc catttttgtt tattgatggc 414901 gtgacggata gcgagcccgg caaacatgcg gcagcttata agctgattag tgagaacgac 414961 tggtttatca ctgatacgca aacagaaatg ccgttttcac ttgtgattga agcgcttgcg 415021 caaaccgcgg cttttacagg aattacagat gagaacagct tgggattatt gtcttcggtg 415081 aagaaagcgg aaaagctggg agaagctgtg cctggtgacc ggcttgatct tacgtttgaa 415141 gtcacgcgca atcggcgcgg gtttgtgttc ggacatgcca aggcatcagt tggagagcag 415201 cctgttgctg aagctgaaat cggcatctat attgaaaaat gaaaaaaacc cttcacaaca 415261 ttttgtgagg ggttctattt tgtgtcgtaa tcccgttcgc tttgagagtt atctctttgc 415321 tggcgtttgt gtttttcatc attcatattt tccttcagct cttcattagg aatcggatcg 415381 gttaagtcgt tgtgctcggg gttttcattt ggtttgtttt gctgtttttt ttctgtcatg 415441 tttgatcacc tcaccgtttg ttttcctctt attcattctc ctcaaacata ggaaatcgct 415501 tttttgtccc gctgggtata atgtattaga atagagagaa gcacaacaaa aagataaaga 415561 gaggtacata tatgtctgtt caaagagaag atgtagatat caagctgatc gcaattgata 415621 tggatggtac actgctgaac gacgagcagc tgatctcgga tgaaaaccgc aaagccattc 415681 gtgaagcgga ggataaaggt gtgtatgtgg tgatcagcac gggccggacg ctgatgacgt 415741 gcagggagct ggcggaatcg ctaaagctgt catcctttct aatcacggca aacggcagtg 415801 aaatttggga ttcgaatttt aatttggtgg aacggaagct gcttcatacg gaccatattc 415861 aaatgatgtg ggatttgcgg aataagcaca acactaattt ctgggcttct acggtgaata 415921 aagtatggag aggcgagttt ccggaaaaca ttacggatca tgaatggctc aaattcggct 415981 ttgacatcga ggatgacgat atccgaaacg aagtgcttga ggagctgaga aaaaacaaag 416041 agctcgaaat cacaaattca agtccgacaa acattgaagt caacgcgctt ggcatcaaca 416101 aagctgcagc ccttgccaag gttacggaaa aactcggctt tacaatggag aatgtgatgg 416161 cgatgggcga cagccttaat gacattgcga tgatcaaaga agcgggtctt ggcgtcgcaa 416221 tgggcaatgc gcaagacatc gtaaaagaaa cggctgatta tatcacggat acaaatattg 416281 aggatggtgt cgctaaagcg attcgccatt gggtactata aaaaaagaga gtcctaagat 416341 ggactctctt ttttagtttg gcaggtttta ttctgggacc atggtaggtt ttctgacaaa 416401 agtatttcac aaactgatat gattcactta taatgaaata aagttcaaaa attcggaata 416461 gtcgttccga atttcgggac aataaatgac ataaagcata tcgtttgctt tggcaggagg 416521 gattctgtgt ttcagattga tttaaactgt gatttaggag aaagcttcgg agcctacaag 416581 ataggccttg accaagatat tttagagtat gtgacatcag cgaatatcgc atgcggattt 416641 catgcaggag atcctagtgt tatgcgaaaa accgtcgcgc ttgcagcaga aagaggcgtg 416701 aaaatgggtg cgcatccggg cttgccggat ttactcggtt ttgggcgccg caatatggcg 416761 atttctcctg aggaagcgta tgatcttgtc gtttatcaaa ttggcgcgct ctctggcttt 416821 ctaaaagcag agggacttca catgcagcac gtcaagccgc atggcgcttt atacaatatg 416881 gcggcagtcg atcaaaaact gtcggatgct atcgcgaaag ctgtctataa ggttgatccc 416941 ggcctgattc ttttcggtct tgctgagagc gagcttgtaa aagcgggaga acggatcgga 417001 cttcagaccg caaatgaagt gttcgccgac agaacatacc aatcggacgg cacgctgaca 417061 ccgcgctccc agccggacgc actcattgaa agtgatgatg ccgccgtcac ccaggtcatc 417121 aaaatggtga aagaaggggc ggtcaaatct cagcaaggac atgatgtgtc attaaaagca 417181 gatacagtct gcattcatgg agatggagcc catgcgctga catttgcgca aaaaatcaga 417241 aaacagctca aagcggctgg aattgaagtg acagctattt cagaacagag gtcaacataa 417301 aggaggaaca atagatggag cagcagaaaa agacagcagg aaaaaaagcg ggcagctggt 417361 cattgctgat gggcgccgcc tttttaatgg cgacatcagc aatcggaccg ggtttcctca 417421 cccaaaccgc aacattcaca aacacactcg cagcaagctt cggttttgtc atcttaatct 417481 ctattatttt agatattttc gcccaaacca atgtgtggcg catcatcgca gtttctggaa 417541 aacgaggtca ggaaattgcg aatatggtgc ttcccggact ggggtatttc atcgccattc 417601 tcgtcgtgct tggcggacta gcttttaata ttgggaatat cggaggggcc gggctgggac 417661 ttcaggtgct gttcggcatt acacctgaaa caggcgcttt aatcagtgcc gttatcgcca 417721 ttttgatttt tgtcatcaag gaagcaggaa aagcgatgga ccgttttacg caaatcgcgg 417781 ggttcgtgat gattatttta acggtctacg ttgcggcgac gacagctcct ccggtcggac 417841 aggcagtcgc aaatacattc gtcccggaac acatcagcat atttgccatt gtcaccctag 417901 tgggcggaac cgtcggcggt tatatcacat ttgccggagg acaccgtttg cttgatgccg 417961 gaattaaagg aaaggaatcc attccgcagg tgacaaagag ctcggttgtc ggcattttaa 418021 ttacatctgt catgcgtatc gctctttttc ttgcggttct aggcgttgta tcgaaaggcc 418081 tgcacatcga tgaaagcaac ccggcggctt ctgtcttcaa gctggctgct ggaaatgtcg 418141 gttataaaat tttcggattg atcatgtggt ctgcggcgat tacgtctgtt attggagcag 418201 cctatacatc tgtttcattt tttaaaacct tttctccaaa aattgaaaag aattcacgcg 418261 gtattattat cggatttatt gtggtttcta cgttagcttt tgtcacaatc ggccagcctg 418321 cgaagatcct cgtccttgtc ggttcactga acggcttaat tctgccgatt gcgctcggaa 418381 cgctgcttgt tgccgcctac aagaaaaaca ttgtcggtga ttataagcat ccgctttggc 418441 tgacaagcac aggcgcgctt gtagtgattg taatggcagt tatgggaatc tacacgttat 418501 gtacacaact tcctcaattg tggagctgat ataagtggag caattaaaca aaatggcgcc 418561 aaaggatgta cgcgccctga tacgagaggg gaaaataaac gggccgaccg caggcatgtc 418621 cggcggctac gcccaagcga atcttgtggt tttgaaaaag gaccttgcgt ttgattttct 418681 gctgttttgc cagcgaaatc aaaagccctg ccccgtgctg gatgtgactg aagcaggttc 418741 gcctgtgccg tctctggctg cgccggatgc tgatatcaga acggactttc cgaaataccg 418801 tatttacagg cacggtatcc taacggaaga agtatctgat attacgccat actgggagga 418861 cgattttgtc ggctttctga tcggatgcag tttctccttt gaacaggcac tgatcaataa 418921 tgggatagct gtccggcata ttgatgaggg gacaaacgtc tcaatgtata aaacgaatat 418981 cgattgtgtt ccggcggggg cgtttcacgg acagatggtt gtcagcatga ggccggttcc 419041 tgaacggctg gctgtacgtg ctgcacaagt gacctcgcgt tttccggctg tgcacggagg 419101 gccgatccat attggcaatc cgggagcaat cgggattcgc gatctcggga aaccggattt 419161 cggagatgcc gtttccattc gtgacggcga ggttcctgtt ttttgggcat gcggagtgac 419221 cccgcaagcc gtggctatga atgtaaagcc tgaaatggtc atcacacatg cgccggggca 419281 tatgctcatc acagatattc gagacgagtc gcttgcggtg ctgtagcctc tcgtcatcct 419341 gatgaacgag aattaaaaga ggtgagaaag atgactgtac gatatcaaat cgaacagctc 419401 ggtgattctg caatgatgat ccgattcgga gaagaaatca atgaacaggt caacggcatt 419461 gtccatgcag cggccgctta tatagaagaa cagccatttc cgggattcat tgaatgtatc 419521 ccggctttta caagtctaac cgtattttat gatatgtatg aagtgtacaa gcatttgcct 419581 caaggcataa gctcaccttt tgagagtgtc aagcgcgatg tcgaagagcg gctggcagaa 419641 atagccgaag actatgaggt caaccgccgt attgtagaaa ttcccgtttg ctatggcggt 419701 gaattcggtc cggatttaga agaggtggcg aagatcaatc aactgtcacc ggaggaagta 419761 atcgacattc atacaaacgg tgaatatgtg gtgtatatgc ttggcttcgc gcccggtttt 419821 ccttttctag gcgggatgtc aaaacgcatt gcagctccga gaaaatcatc gccaagaccg 419881 tcgattcccg caggttcggt cggtattgcg ggattgcaga caggcgttta tccgatttca 419941 acgccgggcg gctggcagct gatcggcaaa acgccgctgg ctcttttccg gccgcaggaa 420001 aacccgccga cattgctgcg ggcgggagat attgtgaaat tcgttcgcat ctcagaaaaa 420061 gactatcacg cctataagga ggagtccaat tgagcatgaa agtattaaag cccggactgc 420121 tcacaacggt tcaggatata ggcagaacgg gttaccaaaa atacggcgtt ctggccagcg 420181 gcgctatgga cacggtttca ctgcgcattg ccaatctgtt gataggaaac ggcgaaaatg 420241 aagcaggtct cgaaataacg atgatggggc ccggtccgtc gtttcatttt tcaaaacaga 420301 cactgattgc tgtgacaggg gcggacttca cgctgcgtat taatgacgag gaagcgcctt 420361 tatggaagcc tgtgctcatc aaggaaaaca gcacggtcag ctttggcccc tgcaaactcg 420421 gcagccgtgc ttatttggcg gcagctggcg gcattgaggt gcctgccgtc atggaaagta 420481 aaagcacata cgtcagagga agcattggcg gacttcatgg cagagcgctt caaaaagaag 420541 atgaactgaa cattggagag atgtcagctc tttcgcaaac catcctttct cgcttaagtt 420601 cgcagcttgg aaaacaggga tttgcagcac cgaagtggtc agtcagccgc ggcagatttc 420661 tgccattgaa gaagaatccc gtcattcggg tgctggaagg aaagcaattt gcctttttca 420721 cagaagaatc aaaaacgcgt ttttatgaag aagcatttcg tgtcacgccg cagtccgacc 420781 gtatgggcta caggctcaaa ggagaaccgc tcgaactgaa ggccccgctt gagatggtgt 420841 cggaagcggt ttcattcgga acagttcagg tgccgcctga cggcaacccg attatcctgc 420901 ttgcagaccg gcagacgact ggcggctatc cgaggatcgc gcacatcata tccgctgatc 420961 ttccgattgt ttcccaaatc atgccgggcg agcacgttca gtttgagcct gtgtccctcc 421021 aggaggcaga agcgcttgcg gtagaacggg aacagcatat aaaagaactg aaaacgagaa 421081 tgaagatgga atggctgaca tagcaaaggg gatgaatgat gcagaataaa aataaaaccg 421141 tagtcaaatc tatggcgctg cttaatttgt ttttgcataa accaagccta accttaagtg 421201 aactggtgtc gctgacggga atgccgaaga cctctgttca ccggatggtc agctccttgg 421261 aggaaatggg gttcctcagt cgggatgcgt ccggcgctta ttcgctggga ttggtgtttt 421321 tggaattcgg acagcttgtc gctgacaggc tggatatcag aaaaatagcg aaaccggtga 421381 tggaagagct gtgccgggaa gtggatgagg ccgtgcagtt gatcatgagg gacggcaatg 421441 aagcgatata cgttgagaaa atagaaggga cacagactgt gcggctgtat acggcgatcg 421501 gcaggcgttc ccccctatac gcgggagcgt gcgccagaag cattctgtcc tttcttcccc 421561 gtgaagaaat cgaagcatac atcaaacaaa ccgagctcat ttcgattggc tccggaacga 421621 ttaccgatcc cgaaaaactg cttcaggaga ttgatgcctc tgtgcaaaat ggctatactg 421681 tcagctattc agagctcgaa aactatacgg cggcgatcgg cgccccgatc tttaaccatg 421741 agcgccaggt ggcagccggc attagcattg caggctttga agcgagattt acagaagaca 421801 ggctgcccta tttaacagaa aaggtgaagg acgccgcttt acagatttca agaaaaatag 421861 gatatacata agtagccaat cttttctctg ctgcgtacat taacgtatcg acgttcaaga 421921 gtggaggaaa gaacatggtg cttcgatata cagctctggg cgattccttg acgacaggga 421981 gaggctccgg gctgttttca cccggcttcg tccagcgttt tggggacatg atggaagctg 422041 acttgaaaac aagaacggca ataaacatat ttgccagatc aggtctgaat acagaagaga 422101 ttttgggact cctgtcatat ccctatgtgc aaaaatgtat tcgagatgct gatatgataa 422161 cgatcacagg gtgcggaaac gatctcatcg attcggtctt agcctaccaa acctctaagg 422221 atgaaacgat tttcagccgt gtatccgccc attgccatga gaattttgaa aagatgattg 422281 ccaaagtcgc cgagattaaa ggagaaaatc cttccccgta cgccattcgt gtgttcaact 422341 tatacaatcc gtttcccgaa attgatatcg ccggcaaatg gatcacttcg tttaattcac 422401 atttagaaac acttgcatca gcaccccatg tcaaaatcgc ggatgcctat agcatcttca 422461 aaggcaaaga acaggaatat ctgtcctttg acggtgtcca tccgaacagc aaaggctatc 422521 aagcgatggc tgaagccgtt cacaagctag gctataaaga attatcagtt tcatagaaaa 422581 cgcgcctcat gacaggcgcg ttttttatgt gtgatcgaaa tattaaaaga aacttaaaat 422641 tctctgtctt ctgttctaca gacaaacaaa gtgcgctaga ataatggagg gcgtaggcaa 422701 atatagccat aacgttcaat atttcgtata taaggaagga tggtcctttt gtttcggatt 422761 tttaaaatgt cttttgcggt tatcattatt atactggcgc ttattgcttt taactatacg 422821 gaacacacct ctgtaatcca atcggtcatg ctcgtctttc ttggtgcggt catgtttatg 422881 caggggcttg aagagcgcaa aaaagaaaat gacggctcag gcgcttttaa tatttatacc 422941 gccgtttttg tatggtctgt ctcccttatc ggttttacac ttcatattat ataaatctat 423001 tacacatcct gaaaatgctc gaccgtcggg aacggggtat agaaccgatg aagcaaggct 423061 ttccactctt gatactctga agaaccgcga aagccttccg tatggtcctc aagtgtttcc 423121 cactccacaa gaagcagata tttatgcgtt tcctccatgc attttgataa cgagtgagtg 423181 atatagccct tcatgccgga aataatcggc gcagcttgcc ggaatgcatc ctcaaactct 423241 tgttcaaggc cttctttaat gtgaagcatt gctgcctctc tgaccatgct atcccttctt 423301 tctgtctttt caaatagtct acagcaaacg ataggagatt tctgcaaaat cggtgaactt 423361 ttccttcatt ttcaaaaaaa tcttgcacgc accaattcaa ttaagagaaa ataacaagtg 423421 gaaggcaggg gaaagtcatg ttaaaaaagt gtattctact agtatttcta tgcgtcggat 423481 tgattgggtt aatcggatgc tccaaaacag attcaccaga ggatcgcatg gaagcattcg 423541 tgaaacagtg gaacgatcag caattcgatg acatgtatca aagcctgact aaagatgtca 423601 aaaaagaaat ctccaaaaaa gatttcgtca acaggtataa agccatctat gagcaggccg 423661 gcgtaaaaaa tttgaaagtc actgcgggag aagtagataa ggacgatcaa gacaacaaga 423721 cgatgaaaca tatcccgtat aaagtcagca tgaacacaaa tgccggcaaa gtcagcttca 423781 agaatactgc tgtgctgaaa ttagaaaaaa cagatgacga ggagtcatgg aatatagatt 423841 gggacccatc gtttattttc aagcagctgg ctgacgacaa aaccgtgcaa attatgagca 423901 ttgaaccgaa acgaggccaa atttacgata aaaatggaaa aggcttagcc gtcaatacag 423961 atgttccgga aattggaatt gttcccggag agcttggcga taaaaaagag aaagtcataa 424021 aagaactcgc caaaaaactt gatttgactg aagacgacat caagaaaaag ctggatcaag 424081 gctgggtaaa agacgattcg tttgtgccgc tcaaaaaggt caagcctgac caggagaaat 424141 tagtttctga agcgacgtca ttacaaggcg taacaagaac gaatgtcagc tcccgctact 424201 atccgtatgg cgaaaagaca gcccatttga caggctatgt ccgcgccatt acagcggaag 424261 aactgaagaa aaagaaagaa ggaacgtaca gcgatacgtc taacatcggt atcgccggac 424321 ttgaaaatgt gtatgaagac aagctaagag gcacaactgg ctggaaaatc tacgtgccgc 424381 aaaccgggga agtcatcgct gaaaagaaag caaaggacgg cgaggatctt cacctcacaa 424441 ttgatatcaa aacgcaaatg aagctgtatg atgaactgaa ggatgacagc ggggcggcag 424501 tcgcgctgca gccgaagaca ggcgaaacac tcgcccttgt cagcgcgcct tcctacgatc 424561 caaacggatt tattttcggc tggagcgata aggaatggaa aaagctaaac aaagataaaa 424621 acaatccgtt ttcagcgaaa ttcaataaga catacgcgcc aggttctacc attaaaccga 424681 ttgcggctgc tattggaatc aaaaacggca cccttaaagc cgatgagaag aaaacaatca 424741 aaggcaagga gtggcaaaaa gattcaagct ggggcggcta ttcagtgaca cgtgtgtctg 424801 agagacttca acaagtcgat ttggaaaacg cccttattac gtcagacaat atttattttg 424861 cccagaatgc gcttgatatg ggagcggaca cctttacaaa aggcttgaag acattcggtt 424921 tttcagagga cgttccgtac gaattcccga tccagaaatc gtctattgca aatgacaagc 424981 ttgattcaga cattttgctt gcggatacag gctacggaca agggcaaatg caaatgtctc 425041 cgcttcactt ggcaactgct tacacgccat ttgttgacaa tggagacctt gtcaaaccga 425101 cgctgatcaa aaaagattca caaacagctg atgtttggca caagcaagtg gtcacgaagg 425161 aaggagcggc agacattaca aaaggtctga aaggcgttgt ggaagatgag cgcggatcag 425221 cgtatcagcc tgtcgtgaaa ggaatcacag tggctggaaa aacaggaaca gccgagctga 425281 aaacatcaaa agatgataaa gacggcacgg aaaatggctg gtttgtcggc tacgattacg 425341 aaaacaaaga cctgcttgtc gccatgatga tccaaaatgt gcaggaccgc ggcggcagcc 425401 actatgtcgt tgagaaagcg aaaaagcaat ttcaatcgaa ttaaaatgtc tttttaaaag 425461 gagcgaaagg aaaaagggga tctgaggccg aatgaactag taagggggca aaacccggtt 425521 tatacaaaga aaagagggat tttgcatgca gcgtattcaa ttggcggagg atcttcaatt 425581 ttcaagagtc atacacgggc tttggcggct gaatgaatgg aactattcag atgctgaact 425641 tctaagcctc attgaatggt gtatcgatca cggcatcacg acctttgatc atgcggatat 425701 ttatggaggc tatacgtgcg aaaagctgtt tggaaacgcc cttgcccttt cgcctggatt 425761 aagagaaaac atagagttgg tcacaaaatg cggtatcgtt cttgaatcgc ctgaacggcc 425821 cgctcacaga tcgcatcatt ataacacaag caaatcgcat attttggcat ccgttgagca 425881 atcgcttatg aaccttagga cggattatat cgatatgctt ttgattcaca gaccggaccc 425941 gctcatggat ccggaggggg tagcagaggc gtttcaggcc ttgaaatgct ctggcaaggt 426001 caggtacttt ggcgtttcaa attttaaaga tcaccagtat cggatgctgg aatcatattt 426061 gcctgagaag ctcgtaacca accagattga gctttccgca tacgaattag aaaatatgct 426121 cgacggcact ttgaacctgt gccaggaaaa acggattccg ccgatggctt ggtcgcctct 426181 ggcaggcggc aaagtattca ctgaaaacac ggataaagac cgacgtgtcc gtacggcgct 426241 tgaatccgtc caaggggaaa tcggcgccgc ttcattggac gaggtgatgt acgcatggct 426301 gtatacgcat ccggccggca tcatgccgat tgtcggaagc ggaaagcgcg agcggatttc 426361 cgccgcgata aatgcgttgt catacaagct tgaccaggat caatggttcc gcatttttac 426421 agccgtacag ggttacgata ttccataaaa agcatcagtt taccagctga tgctttttca 426481 atattgtcac accgcttagt gccaaattac catttataag tgattgattc tttcttgaaa 426541 gcgttttata ttaaaaggaa acctctctat atcctctact gcatctcctt gcgacttcat 426601 ccgcacatca agattggcta ggaggtcttt tttatgtata tgactgccag agaacaaaag 426661 ctgttaaagc acttattatt acaaaacaga tatataaccg taactgagct tgctgagctg 426721 atgcaagtca gcacgagaac cattcacagg gaactcaaat caattaaacc gctgatggaa 426781 accgtggggc ttacgttaga taaacagccc ggtaaagggt tgaaagcagt gggaagtccc 426841 gagggtaaac aaaagctgct tactgattta tcatatgaac agcatgaata cagcgccgac 426901 gaacggaaac tgctcattct ttgttcgtta ttagagtctc aggagcccgt caaactgtac 426961 acgcttgctc atgatctcca ggtgacgaat gccacggtca gctatgactt agatgagctc 427021 gagaagtgga tttctccctt tggactgaca ctgatccgca aaagaggttt tggcatccag 427081 ctcatagggc cggagaatgc gaaacggaaa attgtcggca acttgattgt gaaccgtctc 427141 gacatccaaa tgtttttgga agcggttgaa ttaaacatca aaggaaaaac cgattcttca 427201 gagaaaatgt tcggggttgt cagcaaaggt gagctgttaa aaatggagcg catcttattt 427261 cagctcaaag aaaaaatcgc tttttcattg tccgacagct cctatatagc gctcgtcgtc 427321 catctgacgt atgcgatcga acgaattaag cttggggaaa ctatcaccat ggagcaaaat 427381 gagcttgagg aactgatgaa tgcgaaggaa tacagctccg ctcttgaaat cgcgggcgag 427441 cttgaacgtg ccttcggcgt gacgattcca gaggcggagg tcggctatat tacaatccat 427501 cttcgaagcg ccaatcgaaa atacaaaaca gaatacaaag cgcaggaaat tgagctggaa 427561 acagccctgc aaacaaagcg gctcattgct tttatttcag acaaaatcag aatggatctg 427621 acgaaaaact actctttata tgaaggcttg attgcccatt tggagccggc cgtcagccgc 427681 ataaaagaaa atattgagat atacaatccg atgaaggaac agatcaagcg cgattatttt 427741 ctgctttata tggcgatcga agaaggtgtc gaaaagtatt ttccgggcat gtccttttct 427801 gatgatgaaa tcgcttttat cgttcttcac tttggctcgg ctcttgaaat caaaaaagaa 427861 gaagcaaaag tgaaagcgct tgtcgtctgc tcaagcggga tcggctcctc gaaaatgctt 427921 gcctccagac tgaaaaaaga gctgccggaa attgaatcgt ttgatatgtc atctctgatc 427981 gagctaaagg ggaaggatgt tcaagcctat gatatgattg tgtccactgt accgattcct 428041 tatgaaaaca ttgattacat catggtcagc ccactattaa atgaggaaga cgcaaaccag 428101 gtcaagcagt atatcaagcg gaagattccc cttattctta acaaaaaaag aagctcgaag 428161 gaagaggcgc agcaagctga tgtacctgac atgctggagg cggcggaaag catagggcgg 428221 tatatggaag ttatccaaga tgttctgcgc cattttacgc tagctcaact caaaacaaac 428281 ccggaccata gcatgcttct gctagagctt tttcaacagc tgaagaagga tggcctgatc 428341 cgtgatccgg aaaaagccgc ggtttgcctg gctgagcggg agaaacaagg gggattggga 428401 atccccggaa caaacatggc gctttatcat ctcaaaaatg atgaaatcgt cctgcctttt 428461 ttcaaaatgt ttgatctcag caccccctat gaagtggatg gcatggacgg aaataccctc 428521 aggatgacac gcattctcgt catgatggcg cctggctcat tatctgctga aggctcggag 428581 attttaagcg cgatcagctc ggcaattatc gagagcggag aaagcatggc ggggtttcag 428641 gaagaaggag gacaagaatt gtatcagcgg ttaaaccgca tatttttcac atggatgaaa 428701 gaaaaaaaca tactgtaaac ctgcatggca cacgtcaaaa atttggcgtg tgtttttctg 428761 tggatgggga acaaaataag aaaatgtggg actattttat cattcagtat tggaataatt 428821 ccaaaatgaa atagttttac aagttatctt ttttgggtta aaatgggtga ggtaaggaag 428881 aaaatctaac aaattattga agattcaaga gaatatagga gatgacgata tggaaacatt 428941 acagcatctg attctgcatg acatgccgaa tagcgaagaa atagaggctg taaaaagcgg 429001 agaccataca ctgacatata aaggttaccg taaacggatt aatcagctgg cgaatgccat 429061 gcttcaaaaa ggaattcaaa agggcgaccg tgttgcattg ctttgcaaaa acggccatcc 429121 cgcctcaact gttatgttcg ccgcacttga aataggtgct gttgtcgtac ctgtcagctg 429181 gcagctgaaa ccatatgaaa tgacaggcat tttaaaagca agtgaaccaa aagcgatgtt 429241 ttacggagcg gagtttaaag agatactgga tgaagttctt cctgaattgt cctcactgtg 429301 tgtaacaatg gaaacaggaa cagcttacga aacatctgct gaatttgaag cgctgtttgc 429361 aggtcctgat catttgccag agacggaaat ggtttcacct gatgatacag cacttctgat 429421 gtttacatct ggaacaacgg gaaacccgaa aagatgcatg attacacatg gcggcatata 429481 cagatacgtt aaaaaatcca acagctcaat agcacgtatg aagggccttc gttttctcgc 429541 gtgccatccg atttatcata cgagtgcgct catttgcatc atgcttggaa cgtttgcaga 429601 aacaacattt gtgtttacaa aggatcaaga tcctgttcac atgctgaagg tcattgaaga 429661 agagaagatt cagaccgtga tggctcttcc tgtgttctac acgtatttgc ttgaggcgtg 429721 ggaaaagcac caaactgact tatcttcgct tgttatttta atgacaggcg gaacaaaagt 429781 gccgagcagc ctaataagcc gctatcttga tattggcatt ccgcttgcgc atggctatgg 429841 aagtactgag gcttggggca tcagcacatg gacgcctgat atgggaatgg ataaagcggc 429901 atctgcagga aaacctgtgg caggtgttaa agtcaaagtg gaagatcctc tgaccggaga 429961 agaacttcct caaggagaaa tcggcgaaat cgttgttcat actccattct tatttaaagg 430021 ctatgaagac aatcctgaag caacagcgaa agtgctgcaa aatggatggt ttagaaccgg 430081 agattcagga tatgtagatg aagatggctt tattttcatc acgggacgct acaaggatgt 430141 cattatttac ggaggcgata acgtctatcc tgatcaggtt gaagaagtta tccagcagat 430201 cccgggaatc cttgaaacgg ctgtggtcgg tattcctgac ccgctttacg gtgaaaaacc 430261 gaaagctttt atcgtgaaaa atggcggcca gcgcatcacg gaagaggatg tcatcgcatt 430321 ttgtaaagaa cgcctgtccg cttacaaaat acctgaagtt gaatttgtta acgaactgcc 430381 gaaaaacaac cttggcaagg tgaaaaaaga cgtcctgcgc aatcaggctg tacattcata 430441 aaagaagaag cccgtccact ttatgtggcg ggcttctttg cagttgcaca gacggaaagc 430501 tcaggcttaa tgttcttaaa ttgtatatca atgtcttcga agccggctgc tttaaagtca 430561 gcaatcatct gtcttccaaa tgatttggtt ttctcaggac tggcatccgc ttcccgcggc 430621 tgcatcgtaa tggctgcttt gccgcctggc tttaatgccc gataaatctg ttttatgcct 430681 tttgtttggt cattccaaat ggtgtagttg ttaacggaaa tcactttatc ataaaacgag 430741 gcggggagag gaaatgtctc gatgcttcct tgtatcaggc gtacgccctt tggtttcact 430801 ctgcgggcgg ccagcttcag catggcctct gatacatcaa tcccatgaag atgaacatcc 430861 ttctcgcgtt tcagcatctg ctgcatgcag tatcccgggc caaacccgac ttctaaaatg 430921 ctgtccccgc gcgtgatacc cagctgattg attgtccact gattcagtgt ttgattttca 430981 gcagccatga tgtacccggc aatcatgccg atgacgccct ttggcctgct gaatcttcta 431041 gaaagcatgt taatcattca gcaaccaacc ccctttttga gttaatttcc tctcagcgtt 431101 ccatgtgaaa catttttctg ataaagcaat gcgaaggtgc caagccatgt ttatccaaag 431161 agtgtgtgag gtacacaaca aatagacatg aaaacaaagg aggagaatca tcatggcaaa 431221 ttatccaaaa gaactgccgg cacaaactca aagtcgccag ccgggaattg aaagcgaaat 431281 gaatccaagt ccggtgtatg agtacgagga ttataaagga gcagacaaat taaaaggaaa 431341 agtagctctt attacaggcg gcgacagcgg gatcggacgc gcggtttccg tcgcttacgc 431401 aaaggaaggc gcagacatcg ccattgtgta taaggatgag catgaagacg ctgaggagac 431461 gaagaaacgt gttgaacaag aaggcgtaaa atgcctgctg attgctggtg acgtaggtga 431521 agaggaattc tgcaatgaag cggttgaaaa aacggtcaag gaactaggcg gccttgacat 431581 ccttgtcaac aatgcaggtg aacagcaccc gaaggaaagc atcaaagata ttacgagcga 431641 acagcttcac cgcacattca aaacaaattt ttattctcaa ttttatttga ctaaaaaagc 431701 aattgattac ctgaaaccgg gcagcgccat catcaatacg acatccatca acccgtacgt 431761 agggaacccg acactgattg attatacagc gacaaaaggg gcgatcaatg cctttacaag 431821 aacaatggcg caggcgcttg tcaaagacgg catccgtgta aatgcagtcg cgccgggtcc 431881 aatttggacg ccactaatcc cagctacgtt ccctgaagaa acagttgctc aatttgggca 431941 agatacgccg atgggccgtc ctggacagcc tgttgagcac gtcggctgtt atgtgcttct 432001 ggcatcagat gagtcctctt acatgacagg tcagaccctg catgtcaacg gcggaaactt 432061 tgtgacgaca taagagggag tgagacatat gggcatcacg aaagaagaag tgaacagcta 432121 ctatcaaaaa gcagggattg tattaacgga cgaggaagta gaccaaatcc agctgatgga 432181 ttacggctta ggaaaagaaa gaaaagtcgg gctccagctc ttcgtctacg tcaatacaga 432241 ccgttattgt tcaaaggaat tggtgctgtt tccgggacag acttgcccgg aacaccgcca 432301 tccaccggtc gacggccagg aaggcaagca ggagaccttc cgctgccgct acggaaaagt 432361 gtatctttac gtagaaggag aaaaaacgcc gcttccaaaa gttctccctc ctcaggaaga 432421 cagagaacac tatacggtct ggcacgaaat tgagctagaa ccgggcgggc aatacacgat 432481 tccaccaaac acaaagcatt ggttccaggc cggggaagaa ggtgccgtcg tgacggaaat 432541 gtcatcgacg agcacggata aacatgatat ctttaccgat ccaagaatat aaggatgggc 432601 ttaacagccc atcctttttg tattgaaaaa aacagaatca tcgctataat gggtaaaaaa 432661 ggaaagaggg cgaggcaatg ttcacttgca aggtaaatga gcacatcacc atccgattat 432721 tggagccgaa ggatgcggag cggctggccg aactcattat ccaaaatcag cagcggcttg 432781 gcaagtggct gttttttgcg gaaaatccaa gcagcgctga cacgtaccga gaaacaatca 432841 ttccagattg gcggcgccag tatgccgacc tgaacggcat tgaggcgggt ctcctttatg 432901 acggcagcct atgcggcatg atcagcctgc ataaccttga tcaagtgaat cgtaaggcgg 432961 aaatcggata ttggattgcc aaagaatttg aagggaaagg cattattaca gctgcctgcc 433021 gaaaactcat tacgtatgct tttgaagagc ttgagctgaa tcgtgtggcg atctgtgcgg 433081 ctgtcggaaa cgaaaaaagc agagcggttc cggagcggat cgggtttcta gaggaaggaa 433141 aggcacggga tggcttatac gtaaacggca tgcatcacga cctcgtctac tacagtctgt 433201 taaagcgtga atgggaaggc gaaaaataaa gagcacactt tcttgtttaa atcttccccg 433261 gatgtggaaa agtaacagcg gagacgttaa aaaggagtga ttcgagatga atcagcaaga 433321 cattaaacaa aaagtgcttg atgttctaga tcaccataaa gtaggttcgc tcgcaacagt 433381 tcaaaagggc aaaccgcatt cccgctacat gacttttttc catgacgggc tgacgattta 433441 cacaccgaca agcaaggaaa ctcataaagc ggaagaaatt gagaacaacc ccaatgtcca 433501 cattttatta ggctatgatt gtgaaggttt tggcgacgca tatgtcgaag ttgccggaaa 433561 agcaaagatc aacaattcgg cagaactcaa ggacaaaata tggagttcca aattagagcg 433621 ctggtttgac ggcaaggatg atccgaatct ggtgattctt gaaattgaac cggaggatat 433681 cagattaatg aatgccgggg agaaaacacc ggtctcactc gaactataaa aaatttgtgt 433741 tttcaggggc gatatgttat tatgaatagc tagtaagaaa aataagcaaa taaaaaagaa 433801 agtaaacttc ttttttctgt tttgagagag aagcttaccg cttcccaagc agcataacca 433861 gctgccctta ttcttttcct tcataacaaa tcgcccctaa cgatgagatg gaaaaaagac 433921 ttttttgttt tacaattcac accggcgcgg cttcggagcc gcagtgacga ttgagaggta 433981 gggctttcgt tgtcttgtgt tcaagaaatt tccatggtgt ttactttcca gaatgattct 434041 tcggaacaat gctttatgaa tctaacccgc ctgacttggc ggatgatata atctttattt 434101 gcgtatagaa aagaataaga caaaccgccc ggcgtacgcc ggacggtttt tttattgcaa 434161 aaaacacatc gtactgaaac ctccttgtct tctttccagt cttatctcta ggatgaaatt 434221 ggaggaagaa taacgtgcat gtcattacaa cacaagtact ttttattttt tgttttttat 434281 tgctgattca ctcgatagaa accttagcct atgcgacaag gctttccgga gctcgcgttg 434341 gatttattgc gtccgcgctt tctctgttta atgtcatggt catcgtatcc agaatgtcga 434401 atatggtgca gcagcccttt actgggcatt taattgatga tgctggaaaa aacgcactgg 434461 cgattgtagg ggagcagttc cgctttttaa ttttcggatc gacagtcggc accattttgg 434521 gcattatcct gctcccgtct tttgtcgctc ttttttcacg ggcgattatt cacttggcgg 434581 gcggcggcgg ctccgttttt caagtattcc gaaagggatt ctcgaaacaa ggattcaaaa 434641 atgccctttc ctatttgcgt ctgccgtcca tttcatatgt aaaaggattt catatgcgct 434701 tgattccgaa gcgtttgttt gtcatcaaca tgctgatcac atcgatttat acgattggtg 434761 tgctttcggc tttatacgca ggccttttgg cgccggagcg cagcacgaca gccgtcatgg 434821 cttcgggttt gatcaacgga attgcaacga tgctgctggc tatttttgtt gatcctaagg 434881 tatccgttct tgctgatgat gtggcaaaag gaaaacgaag ctatatctat ttaaaatgga 434941 cctctgtcac aatggtcaca tcaagggtgg cgggcacact cctcgcccag ctcatgttta 435001 ttcccggggc ctactatatc gcgtggctga caaagtggtt ttaataagaa aggctggatc 435061 ataaagatcc agcctttttg cgcttcctta tttatagttc cttaatccgc ggtcgtacaa 435121 aaaatttccg aatgggacga aagcggcgat gaagccggca gctgaccatt tcagcggcca 435181 tttgacagag aaggttgcat aagccaagac aagcaaatac aaaatgaaca acccgccgtg 435241 aaccgaaccg acaattgtca ccgcaagcgg aaggcctgcc caatatttaa gcggcatagc 435301 gatgaacaac aggattaaga gtgacattcc ttcaataaaa cccatcgtgc gaagtcttcc 435361 gatcggcgtg tgcagcataa atcgccctcc ttgtggacac gttttcattt tatactataa 435421 acaatccggg ggggcatatg acagctttca aaaaatgttc ggaaaacatt catttttaca 435481 tgccttttct agggaactgt acttgtcatt tacaaaaata cccgagataa tgtgtacaaa 435541 atcaaaaaag aaggatgttg aaatgaaact tgaccagatt gatctgaata tcattgagga 435601 gctgaagaag gacagccgtt tgtcgatgag ggaattaggc agaaaaatta agctgtcgcc 435661 tccatctgta acagaacggg taagacagct tgaatcgttt ggcatcatca agcaatacac 435721 gctggaggtc gaccagaaaa aactggggct tcccgtttcc tgcattgtgg aagcaaccgt 435781 taaaaacgcg gattatgagc ggttcaaaag ctatattcaa acattgccga atattgaatt 435841 ttgctaccgg attgcgggtg cagcctgcta tatgctgaaa atcaatgccg aaagcctcga 435901 agcggtagaa gatttcatta acaaaacatc gccctacgcg caaaccgtca ctcacgtcat 435961 tttctcagaa attgacacga aaaacgggcg cggttagaga gtgccgcgcg aagtctgtta 436021 taataacagg atgagcgtga aagaaagaga agtgatcaag catgtcaaaa acagttgtat 436081 tagctgaaaa accttcagtc ggccgggatt tagcccgggt actgaagtgc cataaaaaag 436141 gaaacggtta tctcgaaggc gatcaatata ttgtgacttg ggctttaggc catttggtga 436201 cgcttgctga tccggaaggc tacggaaaag aatttcaatc atggcgccta gaggatctgc 436261 cgattatccc agaacccttg aagcttgtgg tgataaaaaa aaccggaaag cagttcaatg 436321 cagtcaaatc ccagcttacc cgtaaagacg tcaatcagat tgtcatcgcg actgacgcag 436381 gccgggaagg tgagcttgtt gcgcgctgga tcattgagaa agcgaatgtc cgaaaaccaa 436441 tcaagcggct gtggatttca tctgtgacgg ataaagcgat caaggaaggt tttcaaaagc 436501 tgcgcagcgg caaagaatat gaaaacctgt accattctgc cgtcgccaga gcggaagcgg 436561 attggattgt ggggatcaac gccacccgtg cacttaccac aaaattcaat gcccagctct 436621 catgcgggcg tgtgcagact ccgacgcttg ccatgattgc aaagcgcgag gcagacattc 436681 aggcgtttac gcccgttccg tattacggca tacgtgctgc agtcgacggc atgacgctga 436741 cgtggcagga taagaaatca aagcagacga gaacgttcaa tcaagatgta acaagccgtt 436801 tgctaaaaaa tctccaagga aagcaagcgg tcgtagctga gctgaaaaaa acagcgaaaa 436861 aaagctttgc gcctgcgctt tatgatttaa cggagctcca gcgtgacgcc cacaagcgct 436921 tcggtttttc tgccaaagaa acgctttctg tcctgcagaa gctatatgag cagcataagc 436981 tcgtcacata tccgcggacg gactctagat ttttatccag tgacatcgtc ccgacgttaa 437041 aagaccgtct ggaaggcatg gaagtaaaac cgtatgccca atatgtcagc caaattaaaa 437101 aacgcggcat taaatctcat aaaggatatg tcaatgacgc gaaggtgtca gaccaccacg 437161 cgattatccc gaccgaagag ccgctcgttc tcagcagtct gagtgataaa gaacgaaagc 437221 tgtatgacct gattgcgaaa cgtttcctgg ctgtattaat gcctgcattc gaatatgagg 437281 aaacaaaggt catcgcagaa atcggcggag aaacctttac ggcgaaaggc aaaaccgtgc 437341 agtcgcaagg gtggaaagcc gtttatgata tggcggaaga ggatgatgag caggaggatg 437401 acagagatca gacacttcct gcgcttcaaa aaggcgacac acttgccgtc cgcacgttaa 437461 cggaaacaag cggccaaacg aagccgcctg cccgctttaa tgaagggacc ttgctgtcag 437521 cgatggaaaa cccaagcgcg tttatgcagg gagaagaaaa aggcctcgtc aaaacgcttg 437581 gagaaacagg cggcctcggc acggtggcaa cgcgtgccga cattattgaa aaactgttca 437641 acagcttttt aatcgagaaa aaaggccaag atatttttat cacatctaaa ggaaaacagc 437701 tcctgcagct tgttccggag gatctgaaat caccggcctt aacagcagaa tgggagcaaa 437761 agctgtctgc gatcgcggcc ggcaaattga aatcggctgt ttttattaaa gatatgaagg 437821 cttacgctca ccaaacggta aaagaaatca aaaacagcag ccaaaccttc cgacatgaca 437881 acattacggg aacggcatgt ccggaatgcg gcaaaatgat gctgaaagta aacggcaaac 437941 gcgggacgat gctcgtgtgc caagatcgtg aatgcggaag cagaaaaacg attgcccgaa 438001 aaacaaacgc acgctgccca aattgccata aaagaatgga gcttcgcggc caaggcgagg 438061 gccaaacctt tgcgtgtgtg tgcggtcacc gtgaaaagct ctctgtattt gaaaaacgaa 438121 aaaacaaaga caaagcgcgt gctaccaaac gggacgtatc ctcttatatg aaaaaacaaa 438181 ataaagatga gccgattaac aacgcgctgg cagaacagct gaaaaaactc ggtttggata 438241 aataataaaa aaacctgtgc ctatcgcaca ggttttttat tggacttagg tcctgttttc 438301 ttaatgttca aaaagggaaa aaaaagctag caatctgcat tttttttctt ttatagtaaa 438361 tgtactttgt aacatggcag tcatattttc gtctataact atttgtgagc gtctgatttg 438421 cttcaggcga caaaggggga tttgcctgtg aggcatgtac taattgctgt catcttattc 438481 ttcttatcta tcggactttc cgcagggtgt gctgaagctg gaaacaagac ccaaaatcag 438541 tcggcgacag aagtgaatgc cagcccgctc cagccggcgg aatatttcat ctatcacaat 438601 ttaatgaatg acaaagggct gatcaaaacc gatttttcag accagccttc ttacttgtcg 438661 gaatctctcg gactgtggat ggagtttctg ctcagcaaaa atgacgcacc acatttccag 438721 gatcaatatc agcatctgac tgattcattt ctgatgagca atcacttggt gacgtggaag 438781 attcaaaatg gccaagcgag cgggacgaat gcgctgatag atgatatgag aattatgctg 438841 tctcttgacc aagccgccgc aaaatggggc cgcagcgact acgcgcaaac ggctagggat 438901 atcggcacgt ctttgaagac atacaatatg aacaacgggt tttttacaga cttttacgac 438961 tcacaggccg cttcaaagga tgtgacgctt tcatacgtca tgcctgatgc cttagctgtc 439021 ttaaagaaga atggaatcat agacgaagaa acagaacagc ggaatgccaa tgttctctat 439081 tcagctcctt taaaaaatgg ctttctgccg aagacataca gctcggagac gaaggaatac 439141 acatatgata gtgaaatcaa cctgattgat cagctttacg ctgcttggca tttgccggaa 439201 ggggatgaaa aagcatctgt tttagcggac tggatcaagc aggaatttca gaaaaacgga 439261 aagctgtacg ggcggtattc ggcatatacg aaggagcctg ccgtccaata tgagtctcca 439321 tccgtatatg ccttagccgt attgtttttg acaaaacagc atgaaaacag ttctgtcatc 439381 aaagccatat atgatagaat gaatgacttt gaaattcatg atccggtgaa atcgtattat 439441 ggaggctata tgagcggcac tcagacgcat tcatttgaca atctgctgcc gctgttagcc 439501 gaaaggaagc tttttaatga aaatatcatt cagtgaatca caaaaattat ttgcttattt 439561 ttcagggctc atcgcggccc tgtctttgtt tatttattat gtgtcagccc agcaatcaga 439621 aggtgctctg atcctttgca tcacatttgg cgtcatcgcc gcaggcatct ggttcggccc 439681 gatttacgcg ctggcagtga ccttaatcgt actctttgtt ctcggcacct taatgatgtt 439741 tttccagact ggacagacat cgctctttcc ggctgaggaa gggctgcgaa tgcttgtcgt 439801 gtggggaatc gcgcttttgc tgttttcttt tatttctgga agaatccacg atattacagc 439861 agagcttcgg cgctcaatga cacggcttca atccgaaatt aaaagctatg ttgctgttga 439921 cagagtgact ggttttgata acaagcaaag gatgaagctg gaactttcag aagaaatcaa 439981 gcgggcggag cgctacggca attcttttgt gtttttgctg ctccatatgc attatttcaa 440041 agagtttaag tctttgtacg gtgaaaaaga aacggaccgc ctcttccaat atgtcggtca 440101 gcaaatcagg acaagcgttc gggaaacgga taagaaattc cgtccctctg acgagcgtat 440161 cgggatcgtg ctgacgcaca cgcctgctga acatatgccg gccgttctga ctaagctgaa 440221 gaaacaattg gatacatatc agctggaaaa tggaaagtat gtgtcgctta cgttccacgt 440281 ttgctatttg ccctaccgca acgatatcca aacagctgat caatttttag aagaactgga 440341 aaacgagatg atgatgaatg aactataaag gaatcacatt gctatgcgtc atgatgcttc 440401 tattttcagc tattgcgtct tttcccgttt ctgcgcaagc gaaagatcag gatgccggca 440461 ttctcatcat ctactcaacc ttggacggca aagagtcgtc acaagtcaaa atgctcgatt 440521 tgcttgcggg ccactttaca tcccatgtga cagtcaaaaa agattcagac gttgaagcgt 440581 cggatttcaa agggaaagac catgtgattt attacggcca aacgaaaaga aagctcagcc 440641 aaaaattgct gtctcttatc agcggcgtga aaaaaccggt tgtcgccatt ggctataacg 440701 caggccaaat cagccaattt tctgggcttt cattagcccg caaagaaaat gtgtttcagg 440761 ttcacagcag gtcagaaaag gccgatgtgt ctctggaaag cgggcttaac gtgctgagtg 440821 tatcaggcct gaaaggaacg gcgctttaca ccttcaaagc ggatgaaggc acaacgcatt 440881 cttttatatg gaaaacaaaa aaagggaatg tgtacattgg attaacaaat ttgttaaatg 440941 acaatttgat cgtggcgaaa cagctcagag aagctttcgg agagaaggcg gggacgacgt 441001 tattgtattt gcgtctcgag gatatcagcc cgatgtctga tgaaaaactg ctgcttcaag 441061 ccggtacata cctgcataag cggcatattc cttttatcct ggcggtcatt ccggtttact 441121 tgaatccgga aacaggcgac aaagtgtatt tgtctaatca accgaagatg gtcaaggtgc 441181 tgaagaagct gcaaagcatg ggcggcagta tcatagttca cggctatact cacgcttatc 441241 gctacagtga aacaggagag ggatttgaat tttgggatgc aaaggcggat cagccgatta 441301 catccggaaa tgccgaagac cccccgtcca ttttggagaa agaacaggac ttcccgaacg 441361 aacaagccta tcacagctat cttgaaccat ttcgggaaaa ggaagaaacg tatacaaaac 441421 aaaaactgac gcgtgccatt gaggatttga catcatcggg tctttacccg ctggcgtttg 441481 aagcgccgca ttacacgatg tccgaatatg gctatcaaat cgcctcgcag tattttacaa 441541 gcattttcgg ccaggtccag ctcagcagca caacatggaa aacatccggt gcacctccgt 441601 ttgtgactgc tccttcgatg ctgcacggaa tgacgcttta tccggaaacg atcggctttg 441661 tcgacacatc gaagcaaaac ccgctcggtg agatggagga gcatatctcc cagatgattg 441721 attttgaagg cggagtagcc ggaggatttt atcacccgta ccttgggatg aaatatctgc 441781 ctgagctggt tgatcagatg gaacgcattc cagacagtga atggcttgat ttaaagaaaa 441841 cgaaacaaac cgtcaaaaca gacaaagtgg aaattcatac aagcggtgac ggaacgattc 441901 aggtgaaaaa cggcgtaagc cccatttacg agtttttcga tcatcaccgg caaacccctc 441961 tggaaaaggc gttatggatt ctctccgctg ttgtgctctt atttgtcatc atgtttgtca 442021 gttatacgtt ttacttgaga gccacattga aaaaacgaat ttttaaggag agaagaagcc 442081 ttgggtaata cgctgttctt tatctcgcta agtttaatat gggttatgct tctctaccac 442141 atgttcctca tgcagggcgg gtttcgccac tatatgacct tcgaacggaa tatcccgaag 442201 tggagagaaa atatgaagga actgccgaag gtcagcgtcc tcatcccggc gcataacgaa 442261 gaggttgtga ttcggcagac gctgaaggcc atggtcaacc tttattatcc gaaggaccgg 442321 ctggagatta tcgtcgttaa tgataattca tcagaccgga cgggtgatat cgtcaatgaa 442381 ttttccgaga aatacgattt catcaaaatg gtgattacga agccgccaaa tgcaggaaaa 442441 ggaaaatcct ctgcacttaa ctcgggtttt gccgaatcga acggcgatgt gatctgtgtg 442501 tatgacgccg acaacacgcc tgagaaaatg gccgtgtatt acctcgtgct cggcctgatg 442561 aatgacgaaa aggcaggcgc cgtggtaggg aaattccgcg tcatcaatgc ggcaaagacg 442621 ctgctgacga ggtttattaa tatcgaaacg atctgttttc agtggatggc ccagggaggc 442681 agatggaagt ggttcaaaat cgccacgatc ccaggcacca acttcgcgat ccgcagaagc 442741 attatcgaaa agctcggagg ctgggatgac aaagcgctcg ctgaggatac tgagctgacc 442801 atccgggtat ataatctcgg ctatcacatc cgctttttcc ctgccgccat cacgtgggag 442861 caggaaccgg aaacatggaa ggtatggtgg cgccagcgca cccgatgggc gcgcggcaat 442921 caatatgtcg tgctcaaatt tttggcgcag ttttttaagc tgaaacgaaa acggattatc 442981 tttgatttgt tttatttttt ctttacgtac ttcctgtttt tctttggcgt gatcatgtca 443041 aatgcgattt ttgtagtgaa tttgttttat gatttgcatt tgtctgttgg atttttggca 443101 atgattctct ggattttggc gtttttctta tttatgacag aggtcatgat tacgttgagc 443161 attgaaaaaa cagaaatgaa caagcaaaac ttttttatcg tatttctcat gtacttcaca 443221 tactcgcagg catggattgt gcttgttatc tactctttat tcgtagaaat caagcaccgt 443281 ttattcaagc aagaggtcaa atggtacaag acagaacgat acaatcaaca taaaagcggg 443341 tgaccttttt gaaacaaata atgatttttc tcacaagctt catgctgctg gcgatgactg 443401 gacaaacggc tcttgccaaa gacgtacagg tcagcggttc gctccttggg aaaagcagcc 443461 aagaacaagc caaacagcag gtgctgacaa gcgagctgat tacactgtat ggatcaaaag 443521 acagcgcaga gctgacgtat cagatcccgg caggcgcctc ttcgggcaat cagcaattgg 443581 taatcgaata cgaggcatca aatcttttaa tttctccatc atcgttaacg gttgtcattg 443641 atgatgaacc ggtcaagacg ttaaagcttg atggtgattc caaacggaaa acagtgaagc 443701 tgaatctgaa taaaagccag tctgcgcaag gctatcacaa cgtatcgctg aaattctacg 443761 gcgtaatgaa agagggcgtg tgcgtcagac aggatacatc aggcaactgg atcaaaattt 443821 atccggacag ccggctgaca cttgctgaca gcagtgaagc gaagggaacg tcgctggacc 443881 attatccgta tcctttcgcc caatctggaa atacagcgga agaaacagct atcgtcattc 443941 cggataaccc aagttcagca gaaatagaag ctgctgttaa aacagaaggc tatttgaaaa 444001 cggtggacag cagtgtcagt attgcgtatg tcacggaatc tgaactgaaa aaaatcgata 444061 agccgacgat tgttatcggc gtggacaagc attggaacgg caaagtgaaa aaactgttga 444121 aacaagccgg gctacaggca aaaggagaaa accttctgct tgcggagcgg gtgctgaaag 444181 cagagggcaa acagcagccg gttctgtttg cgcaagcggc gtccgaggac gcgctcacaa 444241 aaaaaatcag cgtgatgaca gatcagacat atacaggcca gctcagcggc gatacacttt 444301 caatcagcaa gcttcagcag actgaaaaaa aagaaagcga taagctgacc cttgagaatt 444361 ttggagcggg tgatatcaca attggagccg acaaaacatc ttcagcacat tatttttatc 444421 cggcttcggc tgttttagat gaaaaccaat cggcgaagct gtcgcttaaa ctgaaaaagt 444481 ctgaaacgat tcaagcctca acggctgaaa acgagtcagc ctctcaggct gcagaactga 444541 aagtgatgat caacggccag ccgcactcgg tccggcttga tgaattagga aaagaagata 444601 aaaacggatt ctatcatgtc acagtgaaag tggaccctaa gctgctgcaa aaaaaccgct 444661 acattgatat tcagttcgtc acgaccggtt taaaggaaaa caacccttgt aacaccactg 444721 atgaagaaaa gtgggttttt atcgataaaa acagtacatt atcatacgcc atcaaaggca 444781 tgtccccgtc agcggatttt caagagtggc cgctgcctta cgccggaaac caggatcaaa 444841 caacgttaat cgtgcttcct gacaccgtaa gccaatcgaa gctagaggag ctttctctcg 444901 taacagaatc ctttggcaac gaagcacagc attcatatac ggtaaagaaa tcatctgacg 444961 ttacagcaaa tgatgcgaaa ggacgaaacc tcattttcat aggagggatc aatcaatttt 445021 ctcttctgaa ggagaaatca tcagatctgc ttgtgccgca ggaaaagaac ggctcgtttg 445081 atgtatctag tttcgagatg ctgaatgaga cgacaaaaca agtggtattt acccaagcat 445141 cggtttggga ttcacgctat acaatggctg tctttgcacc gtcaaaagga gatggcacgg 445201 ctgtcacaaa agagatcatc agttatctga acagcaacga tgagtcggca accgtcctta 445261 atgaaacaaa cagccagcag gtgtttacaa accaccagca gctcaaatcg gaaacaaaca 445321 gttccgatgc agaacaacca acacaggatc atagccagaa atggatgtat attggtgtgc 445381 tggcactcat tatggtggtt gcggcagtgt tcatttggat tgccgtaaga cgcaaaaaaa 445441 gaaagacaga tacagaataa aacagaggcg attttagcct ctgttttttt atttttggta 445501 agtaaattcc atttgtggaa cctgtcattt tatttttttc tctcagccaa taagcctctt 445561 tacaacgtgc gggaacggga gtatgatctc ttttagaaaa caaatcgctt aatctgaaat 445621 cagagcgggg gacccaatag aacggctttt tgccgttggg gtgaatcctt tttaggtagg 445681 gctaactctc atatgcccga atccgtcagc taacctcgta agcgttcgtg agaggagatg 445741 aatgaaacct gtgttcgatg ttatggcaca ggggcatccg tttgcctctg tgttttttgt 445801 tgttcatttt tgaatgcaaa tcgcatacag agacatcata gcagaaagga ctatcatcaa 445861 catgtgagag caagacactg atggatgttt tattgtttta attgaaaaat gagaaattaa 445921 aaggggaaga catcgatgta tcattcaatc aaacgttttt tgattgggaa accactaaaa 445981 tcccaagcag ctggagagca aaaactgacg aaattaaaag ccttggctat gctttcctca 446041 gatgcgctgt catctgtcgc atatgggaca gaacaaattc taatcatttt ggcaacaatc 446101 agtgcagccg cattttggta ctccattccg attgcggttg gcgttctcat cttgctgctc 446161 gcactgattc tttcatacag gcaaattatt tacgcttatc cgcagggcgg cggggcgtat 446221 atcgtttcta aagaaaatct cggtgaaaaa ccgggattga ttgcgggcgg ttcattgctt 446281 gttgattata ttttaacagt agcggtaagt atttccgcag gcacggatgc catcacgtca 446341 gcctttcctg cattgcatga ttatcatgtg ccgatcgcta tttttctcgt gttagtgatt 446401 atgattttga acctgcgcgg gctttcggaa tcagcatcca tacttgccta cccggtttat 446461 ctgtttgtgg tggcgctttt ggttctcatt gcagtcgggt tgtttaaact tatgacagga 446521 caaatagacc agccagccca tcatacatcg ctcggcacac ctgtagccgg cattacgcta 446581 tttttgctgc ttaaggcttt ttcctccgga tgctcagcgt tgaccggggt tgaggccatt 446641 tctaatgcga ttcctgcatt caaaaacccg cctgcgcgaa acgcggcaag aacgcttgcg 446701 atgatgggga ttttgctggc gattctgttt tccggcatca cggttctcgc gtacgggtat 446761 ggtacggcgc cgaaacctga tgaaacagtg gtttcacaaa ttgcgtccga aacctttggg 446821 cggaatgtgt tctactatgt catccaaggt gtcacatcgc ttattttggt tcttgcggca 446881 aatacgggat tctcagcctt cccgcagctt gccttcaacc tggcgagaga ccagtatatg 446941 ccgcgaatgt ttacagtcag gggcgaccgc ttaggcttct caaatgggat tatcttttta 447001 ggctttgcct ccattgttct cattatctta ttcgggggac agacggagca cttaatcccg 447061 ttatatgctg tgggcgtatt tattccattt acgctttcac aaaccggcat gtgcatgaaa 447121 tggatcaagc aaaaaccaaa aggctggatc ggaaaaatgc tgatcaactc ctgcggcgct 447181 ctgatatcat ttatggttct atccattctg tttgtgacga agtttaatgt cgtatggcct 447241 gtgttaatct ttatgcctat cgtcgttttg ctgttttttg cgattaaaaa tcactatact 447301 gcggttggtg aacagcttcg catcgtagac aaagagccgg aagaaatcaa aggcaccgtt 447361 gtgattgtgc ctgtggccgg tgtcaccacc gtcgtgcaaa aatcgattca ctatgcgaaa 447421 tcactgtccg atcaggtgat cgccgttcac gtgtcatttg acagagaaca ggaaaagaaa 447481 ttcgaaaaac gttgggaaga gcttaataac ggagtgcgtc tcgtgacgct tcactcctct 447541 tacagaagcc ttgtccatcc gtttgataag tttttggaaa cagttgaggc aaaagcgaag 447601 aaggagcagt tttccgttat ggtgctgttt ccgcaattta taacgaaaaa acgctggcac 447661 accatccttc acaaccaatc ggccttcctc ctcagagtcc ggctgttctg gaaaaaggac 447721 ataatggttg ccacactgcc gtatcatttt aaaaagtaaa gctctaggac caagggaatc 447781 accttggtcc tttttagcgg gaaaaggagg tatgggggtg tatacacaag gtgcttttgt 447841 gatcgtattg aacgaaagtc agcaaattct gctggtgaaa cgaaaagatg tccctctatg 447901 ggatttgccg ggcggcaggg ttgatcccgg ggaatcggct gaggaagcgg cagtgcggga 447961 gatattggaa gaaacgggat acaatgcagc gctttctgcg aaaataggtg tttaccaaag 448021 gccaaagttt caagatgaac agcatctgtt tttcggaagc attacaggcg gacaagcaat 448081 ggctgacggc acagagacag cgggattaaa gtgggtttcc ccggggcgtt tgccgctttt 448141 tatggtgccg aatcgaaaaa ggcagatcaa tgatttcaag aacggcgctc aagatgtaaa 448201 tgtcaccgtc aaggatagcg ggttgctcgc ggcgatcgac ctgttgaaaa gaagactggg 448261 caagtgattc aggtctccgg gttttaaagc ctttctcctg tggtattgaa aaaaggaaaa 448321 aggaggatac gttatggcac acaaaactgc aggacaagca atgacagagc tgcttgagca 448381 atggggagtt gatcatgtat acggcatccc cggagacagt ataaatgagt ttatcgaaga 448441 attaagacac gaaagaaatc aactgaagtt cattcaaacc cgccacgaag aggtagcggc 448501 actggcagcc gcggctgaag caaaactcac cggcaagatc ggagtctgtc tgtcaatcgc 448561 agggccggga gcggtgcact tattaaatgg tttatatgat gctaaagccg acggcgcccc 448621 tgtgctggcg attgcaggac aggtttcttc tggcgaagtc ggacgggact atttccagga 448681 gattaagctg gagcaaatgt ttgaggacgt ggccgtgttc aacagagagg tacatagcgc 448741 ggaatcactt ccggatctct taaatcaggc gatcaggacc gcctacagca aaaaaggcgt 448801 tgcggtattg agcgtgtcag atgatttgtt tgcggagaaa atcaaacggg agcccgtgta 448861 tacttcaccg gtgtatattg aagggaacct agaaccgaaa aaagaacagc tcgtcacctg 448921 cgcccaatat attaataacg ctaagaaacc gattatcctg gcagggcagg gaatgaaaaa 448981 ggcgaaacgg gagctcttag aatttgcgga caaagccgcc gctccgatcg ttgttacact 449041 cccggcaaag ggtgttgttc ccgataagca cccacatttt ctcggcaacc tcggtcagat 449101 cggaacaaag ccggcttacg aggcaatgga ggaatgtgat ttattaatca tgctcggaac 449161 gtcattcccg taccgtgatt atttgcctga tgacacgccg gcgatacagc tcgattcaga 449221 cccggcaaaa atcggaaaac ggtatccggt gacagcgggc cttgtctgtg attcggctct 449281 cggtttgcgc gaattgacag agtatattga acgcaaggaa gacagaagat tcctgaatgc 449341 ctgcacagaa catatgcagc attggtggaa cgaaattgaa aaagatgaga cagaggcaac 449401 aacaccgctt aaacctcagc aggtcgtggc ccgtcttcag gaagcggcag ccgatgatgc 449461 ggtgctctct gtagatgtcg gcactgtgac agtctggatg gcgcgtcatt tcaaaatgaa 449521 cgcgaatcag gatttcatcg tttccagctg gcttgcgaca atgggctgcg gcctgccggg 449581 agcgattgca gcgagcttgt ccgaaccgga acgccaggcg atcgccgtct gcggtgacgg 449641 gggattttcc atggtcatgc aggaccttcc gaccgccgtt aaatataagc tcccgatcac 449701 agtcgttatt ttaaacaacg aaaatctcgg catgattgag tacgagcagc aggtcaaagg 449761 caatatcgac tatgtcacaa aacttcaaaa tgtcgactat gccgcatttg cagaaagctg 449821 cggagcaaag ggcatcaaag tgaccaaagc ggaagagctt gcgccggctt ttcatgaggc 449881 gctgcactct gaccaaccgg tcgtagtgga tgtcatgatt ggaaacgaac cgccgcttcc 449941 tggcaaaatc acctacgggc aggcgaaagg ctttagcaag tacatgctga aaaacttctt 450001 cgaaaaccaa aaatttgaaa tgccgtcact gaagaaaagt ttgaaacggt tattttaaaa 450061 aaacaggggc cctaagagcc cttgtttttt tttttttttt tggaaacaaa tgtattttca 450121 gcatgtttga attcataaaa tgatcggtat atgtattagg aactgatttc gccatactcg 450181 aaacagacaa aaggacaaat gcatcttgtt tcaaaggaag atgcatttgt ccttgcatgc 450241 ttattcttat caaatcttac agaactcttc tcataatagg ttatttttct tttttcttca 450301 gcccgaagaa gaaaggaaaa gcagaaccga ccaagaaggt gccgaataaa aacatgccgc 450361 cgataaacac gtggaaattt gtgtgtccgg ccgtaaacgc cgtgattagg gaaatgatac 450421 tgagcacgat catggcaatg ccgggcgcga ctctcatttt tcccttggat ttatgggcag 450481 caacagaaca taaaatgccg ataacaatag gaacaatcca caaataaaac agaataaata 450541 ctgacatcat caaaactccg atttttcttc tatcataaca aatttctgtc aaaaagggta 450601 tcaatgagct tttgcggaaa aataaaaacc ggctttagaa gccggttttt ttatcgaaac 450661 gtatctacaa ttaaaaacac attcaaagca acgatcaata cagcaatcag ccaagacacc 450721 actgtgatcc atttggcgtt gatcagagat cccatgatcc gtttattgct tgtaaacata 450781 ataagcggaa tgagggcaaa ggcgatcccg aaggacagca cgacctggct cagtacgaga 450841 gcggtcgtcg gattaacacc tgacgcgatg atcaagatcg gcggaatgat cgtgataaaa 450901 cgccgtacat acagcggaat gcggtagttg ataaatcctt gcataatcac gtcgcctgaa 450961 agtgtgccga cagacgaact ggatagaccg gcaacgagca gcccgatccc gaacaaagcc 451021 gcagacatag ggctgacaag atgtccgaat tgctgaaatg cgacgtcgag atcctcaaca 451081 aacaggccgt ttttgaagaa taatgcggca gccacaatca gcatacttgc attaatagcc 451141 cctgcaatca gcatcgctat taaaatatca ataaattcaa acctaaagat ttttttccgt 451201 tctgcatcag ttttgccaac cacccgccgc tgtgtaaggg cagagtgtaa ataaatggcg 451261 tgcggcataa cagttgcgcc aagaataccc gctgcaagaa gcacactgtc ggtgccatga 451321 aacgccggga caaaaaggcc cttcatcact gacacggcat caggctttgc gaaaaaggtc 451381 tgcaacgcaa aggcgatcac gaccacaaac agcataccgg caatacctgc ttcaagtgag 451441 cgataaccac ggcgctgaag ctccaatatc gcgaaagaac cgatcgccgc aataatagac 451501 gcttcaagca tcggaatgcc gaacagcaaa tacagtccca gagccgctcc gataaattcc 451561 gccagatcag ttgcgataat gaccaactcg ccctgaatcc ataatccgat cgagacaggc 451621 ttcgggaatt cttcacgggc aacctcaggc agatttttgc ctgtcgcaat accgagtttg 451681 gcggataggg attgaattaa aagcgccatg atattggaaa ataagatcac ccataagagc 451741 atatatccgt atttagaacc cgccgaaata ttcgttgcga agttgccggg atcaatatag 451801 gcaatggctg ctataaatgc agggccgaga aaagggagca gccctctgaa tcctctgatt 451861 ttcccgtcaa gcgcatcttg gacggctttg gaacggggag attgtgctgt gatgtccttg 451921 ttcatcatgt ctcacctgaa ttctgtttgt ttttgccgta caacaaagag tttccttaag 451981 gcaaattatt ttatctacat catatgacca tcccggtttc ttgtcaaccg aaaatgttca 452041 aaatacactt ctgaattttt ccctgttatg taacatgata tgtagggatt cgtgataagg 452101 tcccatataa aaagacatcg tttcatttcg aaacgatgcc tcctgtatct aatgagtcta 452161 ggcttccttc cgcagcccgc ggaatataag gcccagcaag aacacgaaga tggctgcccc 452221 gatgatggcc gggaaaatag caaagccggc gaggctcggt ccccatgtgc caagaagtcc 452281 gtgcccaatc caagcgccga tcagcccggc aatcatagag ccgaaaattc ctcccggcag 452341 ccggtttcct acaatggcgc tcccaattaa tccgataaca attgcaacaa ctaatgaaac 452401 caaaaagcta agcatcatga tcacctctca taaatgattt accaatcaat aaccgctcct 452461 gatcatttcg aaacacttga aagcatattc ctttatgatc ctgttttaat ctttctctgc 452521 acactgccgt cagctaaatg aacaatgacc tcagtgcctt tatgcgccgc gatttccttt 452581 gcccgttcaa tcgcttcttt ctttgtatcc ttgatttcag acacacgttt ggcgccctcg 452641 gctttgactg cccagccttt tttatgctta ataacatgct ctgctttatt catgagctcg 452701 gggccgctgc cgctgcttgg atcagcatcg cgttctgtct catcatcatg cgtcaggaaa 452761 tcatcaattt catctgtaga ggcgttttcc gcccattcct tcgctttgct tgtcgcaatt 452821 ggaatcgcgc gcccttcctc atagccttca tcaatcatcg cattcgcaat gtctatcgcc 452881 ttttttctca ccggcttctc aagatttttt aatgaagcag gataatcctt catcgaccaa 452941 ggcatgtcta tcactccttt tccttttata aaaatggtac ccgcaggtga aaaataaaaa 453001 cgcatccgaa aaaatgaagg tatactatat agtagaaaaa acggaaggga agtgcgggtt 453061 gggtgccaac agaacgaaaa gaagacttac atcagcaatt aaaagagata gagaaatggg 453121 aaaaagatca gcaaaaagtc tggttttggg aaaagctcag ccgtctcccg tttcaactcc 453181 tggacaagct gacaccagaa ttcatccaga aaaagatcgg caagctcttg gatgaggtcg 453241 gcagctttgt tcaaacaggc ggacagtacc tgacatctga aaaacagatt atcaggatgt 453301 ttcaaaagaa actgccggag gagatctttg aatcgctgga ggacatccgg aaagcgcctc 453361 ttcctgtcat ggatgaaatt gcggaaggaa tgggcaaaaa cagaaccaac gcagcaaccg 453421 ttcaaggcgc gacaaccggt gtgggcggcg tgtttacgct ggcggcagac attccggcag 453481 tgcttggctt atcactaaaa acattacagg atatcgcagt cgcatacggc tatgacccaa 453541 aggagaaaaa agaacgagtc ttcattgtga aatgcctgca gcttacgtcg gctgatgttg 453601 tcggcaaaag atcgattttg caggaattaa aacactacga tcaagaccgt acatataaga 453661 atgtcgcttc tcaaatccaa ggctggcgag aagtcgtttt gggctatcga gacacgtttg 453721 gctggaaaaa acttttccag atagtgccgg ttgccggaat ggtttttggc gccgctgcca 453781 atcgctcaac attaaacgac attaccgaga caggcatgat gctgtacaaa aagaggcgca 453841 ttcttgaacg actgaaagaa acagaacgag agatggaata gcagaaagca gacggacacc 453901 gcgatccgcc tgcttttttt agtggaaaca tacccaatgt gttttgtttg tttaaaagaa 453961 ttgtgagcgg gaatacaaca accaacacca attaaaggag gaattcaaaa tggcagacaa 454021 taacaaaatg agcagagaag aagcaggtag aaaaggcgga gaaacaacaa gcaagaacca 454081 tgacaaagaa ttctatcaag agattggtca aaaaggcgga gaagccacta gcaaaaacca 454141 tgacaaagaa ttctatcagg aaatcggcga aaaaggcgga gaagccacta gcaagaacca 454201 tgacaaagag ttctatcaag aaatcggtga aaaaggcgga gaagccacta gcgaaaatca 454261 tgacaaagaa ttctatcaag aaatcggccg aaaaggcgga gaggcaacaa gcaaaaatca 454321 tgataaagaa ttctaccaag aaattggctc aaaaggcgga aacgcccgca acaacgacta 454381 atcaaaagca taaaggcaga caacctgtaa ataaaaaagc gatccggcac atcagctgga 454441 tcgctttttt ttggaatctt ctcaatttat gccgctattg agatacaata agtgaaaaag 454501 gggttttcgc taatgtccaa gatgcaaaac ttgctcgcca tcgcaaatga agtcaaagaa 454561 aagcacgcca atttttcaat ctcagaggtc aacgaccact gcgtgcgcct tgcggtgttt 454621 acgggagaat atgactggca ccatcaccct gactcagacg aattgtttat tgttcttgaa 454681 ggggagctgc tgatcgattt taaggacaaa gaaaccgcgg tgctcaaagc aaatgacagc 454741 ctgctgatcc ctaaaggcac ggttcaccgc acacgctctt acgtcagaac ggtaaatctc 454801 tgtgtggagc ataaacaagc cgaaaccgtc atcatagagg agcagccatg ctaatcaaaa 454861 agatgatatg tgaagtagat gctgcaaacg ctgaagcatt tgcaaaagcg cagtcacagt 454921 gggaagcgtt atcgcatata agcggcttta tcaaacaggc cggcggctgg cgaaaaacga 454981 tagacgagcc gctcaccgca gaaatcatca gtgtatggga aaacagagaa gcctatgatc 455041 attttatgga gaacgaacat gacagcatat acgaggaaaa cgatcagaag gctgtaattc 455101 tttcgataga ggtgacggtg tacgaagagg ataaaccgtt cgttcacgat ctgttacata 455161 accccgatat ccggtacgaa ccaaactgga cggttctgaa ggcataatca aagcccaaaa 455221 catcatgttt tgggcttgtc tctttactcg cgtcccggaa gtgtattatg aacaaaaggc 455281 ggtgctggtt ttaactccgg tttttctcca aacgtttttg cttctttcac atattcaaag 455341 gcttctccgt ccggcgcttt ttcattcagc cagttttgct cggcgcttac ttcgccttca 455401 gagaaattga taagctgatg tgagaactct tgtttttcga gcgctttcgg gaatgtaccc 455461 ggcacaaccg gaccttcctg tgcttctaat tctttaatgg cggcgagcca ttggttctgg 455521 tgcatcgtgt cacgcgccag caggaagctg agcatatctt tgacgccttt gtcatccgtc 455581 atttcaaaca ggcgtgcgac ctgcagacgg ccctgagatt ccgcattcag gttggcgcgg 455641 aagtctgcca gcaggtttcc gcttgctacg atataaccgc cgctccaagg tacgcctgta 455701 ctgctttccg gcatggcgcc aagtcctgat acaatcgcat ggtgagggtt catgccgcct 455761 aggatggagc cgatgaccgg atcttcagca gctttttcct gctgatcaag aggggcatcc 455821 tcaagaagtc tggcaatcat cgttgcgatc atttcaacat gcccgagctc ctcagttgcc 455881 gtatccatca gcaagtcctt gtatttttca tttcctcttg tgttccagcc ttgaaataag 455941 tactgcatgg caactgaaat ttctccgaat tgcccgccta aaatttcttg cattttttta 456001 gcgaataatg gatctggacg atctggttta gcaggatgct gcagcatttt tgtgtgctta 456061 aacatgtacc catctccttt ttcgtttatc tctttttata tttccgatcg atagaaagat 456121 aaacgaaaaa cagcgtatcg agatgggaac tatgaatctt ttcgcagctc caacagttcc 456181 cggatcagct cccggccaaa gatgggctca tactgccggt aaacagggtc aagacgcttc 456241 atccattctt gtttctcttt atctgacagc tcataaatat gtatagcaga attctttttg 456301 atttcttcca gctgctcctt gttcatttgt tcggcatacg tttcattcca ctccgttgtc 456361 tccttcatcg cttcagtcaa aatgcgtctt gtttctggtg tttgcgcctt ccagaagtgt 456421 tcatcagtca tgacagcgta gccgagataa ccgtggctgc ttattgtcaa atagtcctga 456481 acattataaa attttttaga atagatgttt gaaattgtat tttcttcgcc atcgactaca 456541 ttgttttcta acagctgaaa ggtagaattg aaggattcct gatgaggtgt tgcgccaagc 456601 agcttgaact gatcctcaat cacatcgctt tgcataatgc gcagatcctg cccttttaag 456661 tcatccggtg ttttgaccgg cccttgattt gttgtgattt gcttaaagcc gttcgtccaa 456721 taggccaatc ctttcaattg gtttttcttt agagaatcaa acagctgtgt gccgatgctt 456781 ccgttcagcc cttttttgac ggcgttgtaa tctgtaaatg catacggcag atccagcact 456841 ccccattcag gcgagagcat gccgagcttc gatgtggagg gggcgataaa ttgaacatcg 456901 ccgttttgca atgcttcaat ttcttcaatg tccgagtaca ggcttccatt cggaaatact 456961 tctattttta tttttccgcc tgatttttcg ttcaccagat cagcgaattt attggcggcc 457021 agcccttttg gcgtattttc agcaaccacg tggctgaatt taaacacgat ttgatcctgc 457081 aggccttcct ggtcgtcatc ataaacaatc tttttattgc cggtatgatc atggaatccg 457141 ataaataaag cggttgcaat tccagcgatc atcagtgcga gacatgcaag caaactcttc 457201 atgaaaagcc ctcccctatg ttaaggataa tgggggctat gacattcgta aagacctgaa 457261 aggagaagct gatgaacaaa aagaagctct caatccgttg gaaaatcacg atcttatcct 457321 atatactcgt cattttctcc tttttgatcg gcggcattgt gctcatcggc aacattcagc 457381 atacagagga gcgggagctg aaaaagcggc tgatgaatac ggcccggacg gtgtcagaga 457441 tgacagaagt gaaagaagcc ttggcgcgaa aaaaacaaac agaagcggtt cgccatgcgg 457501 ttgaagaaat caggatgatt aatgaagcag actatattgt cgtcatggat atgaatcaca 457561 tccgatatac gcatcctgtc agcacaagca ttggcaagaa atcagaaggt gcagacgagg 457621 aggcagcttt tgcggagcac atttatttct ctgaagcaaa gggcgagatc ggcacggcgg 457681 ttcgcgcttt ttatccggta aaggatcaag acctgaacca aataggcgtg gtgcttgtcg 457741 gaaaaacgct gccggggatc gctgacatcc tgcttcattt aaagcgtgat atcgccttca 457801 tcgttgtgct gacactcggc tttggccttg ctggttcctt tttgctggcc cgccatatca 457861 aaaaacaaat gtttcagctt gaaccccatg agattgtccg aatgtatgaa gaacggacag 457921 cgacgtttca ctcgatgaat gaaggggtga tcgctattga caatcgtctc gtcattacga 457981 tcttcaatga aaaagcgaaa cagatctttg aagtgcaggg ggatctaatc ggcaaggtga 458041 tttgggaggt tctcaaggat tcgcgcctgc ccgaaatcgt ggagcggaac aaagcggttt 458101 ataatgaaga aattcgtgtc agcggtaagg tgatcatgag cagcagaatt ccgatcgtca 458161 tgaagaaaaa agtgatcggc gccgttgcga tttttcagga cagaacggaa gcggccaaga 458221 tggcagagga attgactggt gtcagaaact ttgtggaggc gctccgtgtc caaaaccatg 458281 agcatatgaa taagctgcac acgatcgccg gtctcatcca gctggggaaa tctgaaaaag 458341 ccttgcagct tgcattccag gcgtcaactg agcaggaaaa tgtgactgaa tttctgcacc 458401 gctcgattca aaatgacgct gcggcaggcc ttctattaag taaaatcaga aggggaagag 458461 agctcggcat tgctgttcat atagatgaaa acagcagtct tcagcaattt cccgagcatg 458521 ttgatcagca tgatattgtc gtgcttttgg ggaatctgat tgaaaatgcc ttcggctcat 458581 ttgaaaccgt tcaatctgaa gacaaacgaa ttgacattag tatcgaacaa acagatgata 458641 tccttgctat tttaatagaa gataacggct gcggaattga accgacacat atgcctcgcc 458701 tttatgacaa aggttttacg gtcaataaaa ctggcggcac aggctatggc ctgtatctag 458761 tgaaacaaat catagacaaa ggatcgggca cgatagaagt tgattcacat gcggggcagg 458821 ggacatcttt ttctatcgtt tttccaatga agggggagga agcacagcat ggctcgtaaa 458881 gaatggaagg ttctgctcat tgaagacgat ccgatggttc aagaggtcaa taaggatttc 458941 attacaactg ttaaaggcgt tactgtctgt gcaacggcag gaaacggaga ggaaggcatg 459001 aagctgatta aagaagaaca gccagatctc gtcattctcg atgtgtacat gccgaaaaaa 459061 gacggcatca agaccttgca ggagatcaga aagcaaaagc ttgaagtgga tgtcattgtc 459121 gtctccgctg caaaagacaa ggaaacgatc tcactcatgc tgcaaaacgg ggcggttgac 459181 tatatcttaa agccgtttaa gcttgagcga atgagacagg cactcgaaaa gtacaagcaa 459241 tataaacaaa aaatcgaagc gaatgatacg ctgtcccagg aacagctcga tgcgatcctg 459301 aatattccgc agcaggccgt acaggatctg ccgaaagggt tgaatcactt cacgatgaat 459361 gaagtcactg cttttttgaa acagcaaacc gcatcccttt ctgctgaaga ggttgccaag 459421 gcgctcggca tcgccagagt gacagccaga cgatatcttg attacttaga aaaaaccggg 459481 atcatcaaat tggacgttca atacggcgga gtcggccggc cggtcaaccg ctacgtgtta 459541 aaaggataaa cctgagacca aaaagaccaa aatgtccgtt atgatcataa acttccccag 459601 actgtatgaa aacgctatca ttctagtaag aaagacacaa aaggcgaata ggacaggggg 459661 atgaaggata tgaaactgtt taaaaattta acagttcagg tcataaccgc ggtcatcatc 459721 ggggtcattg tcgggctggt ctggccggat gtcggcaaag aaatgaaacc gcttggtgat 459781 acatttatca acgctgttaa aatggtgatc gcaccaatca ttttcttcac aatcgttctc 459841 gggattgcaa aaatgggcga tatgaagaag gttggaaaag tagggggaaa agcgtttatc 459901 tatttcgagg ttgtcaccac cctcgcactc attatcggtt tatttgtcgt caatattatg 459961 aagccgggtg cgggtcttga ttacagcaag cttgaaaaag gagatgtatc acaatacacg 460021 caaaatggcg gtcagggaat cgactggatt gaatttatta cacacattgt tccgtccaac 460081 atggttgatg ccttcgcaaa aggggacatt ttgcaggtct tattcttttc tattcttttc 460141 ggagtgggtc ttgcggcatt aggcgaaaaa ggaaaaagcg tcattgattt cttcgacaag 460201 gtttctcacg tttttttcaa aattatcggc tacattatgc gtgccgcgcc aatcggggca 460261 ttcggggcga tggcgtatac aatcggacac ttcgggctcg attccatcaa accgctggca 460321 agcttaatga tgtctgttta tattacgatg ttcctgttcg tatttgttgc tttaaatatc 460381 atctgcaagc tttacggatt cagcctgtgg aattaccttc gcttcattaa ggatgagctt 460441 ttgatcgtgc ttggcacaag ctcttccgaa tcggtgcttc cgcgtatgat ggataaaatg 460501 gagcgctacg gctgttccaa atccgttgtc gggcttgtta ttccgacggg ctattcgttt 460561 aacctcgacg gcacatccat ctatttatca atggcgactg tctttttggc acaggtgttt 460621 ggagtagacc tcagcatcgg ccagcaaatt acgattatcc tcgttctgat gctgacatcg 460681 aagggagcgg caggtgtgac gggaagcgga tttatcgtcc ttgcctcaac gctgtcagcg 460741 ctgcaggtca ttccgctgga ggggcttgca ctcctgctcg gggtcgaccg tttcatgagt 460801 gaaggaagag ccattgtgaa cctgatcgga aacggaatcg ccacgatcat tgttgccaaa 460861 agcgaaaatg aatttgatga agcaaaaagc atagaggctg ttgaaggcat gaaaaaaatg 460921 aaaacagcag tctgaaaaaa gaacggccca tccatgggcc gtttttttaa ttgtttaaga 460981 attattaagg taaggacaga gacctcagca tttttttgtt atataattta caaatggata 461041 ctatattgaa tgaaggacgt ttgtcctaac aggagtgtat aaatggccgc tttagttaaa 461101 ttttttcagc acccgggagt aaggcgtttc tccatctttg tcgtgttaac tggtgtgtta 461161 tatctattta agagcatgat caacttaata ttgcttacct tcattttcac atttctaatg 461221 gatcgtttgg agcttgtcgt gcggcagttt gtaagccagt tcttccgcgt gagccagcgg 461281 gttgtcatta cgtttcttta catgttgctg gctgtgctgc ttacagtcgg gggctttgtg 461341 ttttatccgg tcgtcgcggc gcagatccag cagctggtaa agcagattaa acatattgcg 461401 tatcatcctg acagcatccc tttctttgat gagatcacca gtgtcttcgg agatattaac 461461 atcagttcat atgtcaaaga gggcttcaat gtagtgtata cgtatctggc cgatatcagc 461521 acattcggct tgcaggtcgt gatggcgctc attcttagca tgtttttctt atttgagaaa 461581 aaacggcttt ctgaattcat ggcgaaattt aaaacgagca aacttagggt cttttatgag 461641 gagattgctt ttttcggaag caaatttgca agaacgttcg gcaaggtgct cgaggctcaa 461701 tttatcattg cgctcgtcaa ctgtattctg acgtttatcg cgctttggat tatgcatttt 461761 ccgcagctgt ttgggctttc gattatggtg ttcttccttg gattgatccc tgtagcaggc 461821 gtcgtcattt ccctgattcc gctcagcatt atcgcctaca gcactggcgg tggaatgtat 461881 gtgctctaca ttgtccttgt catattcgcc attcatgcga tcgaaaccta tttcttaaat 461941 ccgaagctga tgtcggcgaa aacagagctg ccaatctttt tcaccttcac agtactcatt 462001 ttctctgaac acttcttcgg catttggggt ttaattatcg ggattccgat ctttgtgttt 462061 ctccttgata ttctggatgt caccaacaag gaagataggt ctaaaggacc ccgagagaat 462121 agcgataaaa agtagtttaa aatcgaataa tgagtgtgcc tcgatctgcc ggcctgcctg 462181 ttcagggcat ggaattaaga ctcggaatcg gagcttggca ttgccttgca cagtggtgaa 462241 cacaacaggt gacaatgctt gtcatcagta cggaaactga aaagaacaaa cagtcggagc 462301 aaacgctcat catcggttta accaaacatt tggaagcaac aaatgctata atacaaacag 462361 tgcctaatgt tgggcactgt ttattttttg tcgaaaaagg aggaaggctt tatggctgag 462421 ccgattttac atattgaagg cctcgataaa aaaattgggt ctaaacagat tttaaaacag 462481 atcagcatgg acgtcatgga gggtgaaatc atcggccttc tcggtccgaa tggttccgga 462541 aaaacaacac tcatccgtat catcgtcggg ctgttgaaac aaaacagcgg aagcgtgaca 462601 atcagcggat tccagcatga tacagagttt gaaaaagcga tggaagcggt tggagcgatt 462661 gttgagaacc ctgagttcta tccgtacctg acaggctggg aaaacctcaa gcactttgcg 462721 aatatgcaca aaaaaatagc ggatgaacgg cttgatgaag tggtggaacg tgtcgggctg 462781 acgtcagcga ttcatgataa ggtgaaaacc tattcccttg ggatgcgcca gcgtctggga 462841 atcgcccagg caattcttca ccggccgaag cttctcattc tagatgaacc gacaaacggc 462901 ctcgatcctg cggggatgaa ggattttcgg gatcatatta aggaactcgc agaaatggaa 462961 ggaacagctg tcctgttcgc cactcattta ttgcgcgagg ttgaagactt gtgcgaccgt 463021 gtcatcatca ttcaaaaagg tgagatcaaa gcggaagtca gcttacaagg aaccgatcaa 463081 accacagaaa aagcgattat agaagtgcag ccgcaagaaa aagcgctcaa ttggctgaca 463141 ggcaatcaat atcaagctga gagccaagac gggacgattg tagttgaggt ggcaaaagaa 463201 aacataccgg agctgaaccg atcacttgtc ggacaagatc tgaatgtatt ttccattacg 463261 ccttacacgc agtcactgga agacgaattt ataaaagcga caacagctca tcaagaggag 463321 ggagaagagc ttgtctaaat taatttggaa tgaacatatg aaacttttta atcggaaggt 463381 cactttggtt tctcttatcc tgatggctgt ctttcaattc ttcatggcat tgatcattaa 463441 acggattgtc atcagtgccg gaacagatga aaacttcatc ggctatttat cgtatacacc 463501 gagcctgaac attttgctgc aggctttaac gatcgtaatt gcagcaacaa ttgtttcgat 463561 ggaatttgat aaaaagacga tcaaattttt gctcattcgt ccggttaaac gccaaaaggt 463621 cttttggtca aaattaatca cagtcgtgat ggtcagcttc tatttgtatt tggcatacta 463681 cattctggca ttattattcg gtctcttgtt ttttggcaca tcggtgactg cggaatcaaa 463741 gacattgctg gtcaacacct tggcgctgat cgggtcaaac tggcttgaag ctgtaatgat 463801 gggattattc gggctgcttt gttcttcgct gttccgcaat agcgcggtag cagttgttgt 463861 ttcttttgtc gttttatacg gagcgagtac acttgttcag ctcatgaagt tgtttgaaaa 463921 caagtggggc agctttttgc tttttgcgaa cactgacttt acgcaataca gaagcggaga 463981 gacagcgttg ttttcaggca tgacgccatt gttttcaatt ggaattctca tcatacatgc 464041 catattcttc atcgttgttg gctggtggtg cttctgtaaa cgggatgttc gggtctaaag 464101 gcaaggaatg acatttttgt gaaaaagctc acgtaaatca atatcatttg atattttggt 464161 ttatactaaa ggtactgacg gaggtgtctc gattgaggaa ctttattacc gctttaccga 464221 tcgtattgct gcttggattc tcatttgtgt cattcatgtt tcagtttgaa catcttgttt 464281 atttcaggct cgcgcttggg ttgttttctc tcgtgggact gtacatgata tataaaatga 464341 agacgggcat ccgctatttt atcatctatc tgtatgccag ctggattgtg ttggccgcag 464401 tgaccgcttt tgaagagccg attttctcaa gctttttctt tggcggcctg gtgatgacga 464461 tgggttacct gacatatatg ctgatttatc tcggcatgaa acaagaccgg gatgcaaatc 464521 ctgtgtaatc gcgctgttcc cttggggaac ggcgtgtttt tctatactgg gcaaaaggtt 464581 aacagttgcg gaaaaatggc aggaaatcta taatacatat taaatttatc ggaattaaaa 464641 ctggggggct gccggatgtc attatttata caaaacgatc aacagcggca atggatggag 464701 aaaatcggac ggattgcgga tgaatttcag caaacagctg ctgaagatga cgaacaggga 464761 cgttttcctg cagagaaaat acaaaaactg cgtgatgctg ggtatacagc attaacattg 464821 ccggcatctc atggcggagg gggcatttct gtttacgata tgctcttgtt tcaagaacgg 464881 cttgcacggg gagatgctcc gacggctctt agcatcggct ggcatttgag cgtgatcggg 464941 gagcttggag aaggcaacag ctgggatgaa gacgtatttg catttgttgc caaggaagtc 465001 caaaacggag ccgtcattaa cagggcggcg actgaagcga aaaccggaag cccgacaaga 465061 ggagggcgtc ccggtacaca cgccgtcaaa aaggatggca aatgggcagt gaacgggaga 465121 aaaaccttta cgacgatgtc acaagctctg gattattttt tagtaaccgc atggattgag 465181 gacaaacaaa caacaggcgt gtttctcatt cataaagatg atcccggctt gtcgattgaa 465241 gaaacgtggg atatgatggc gatgcgggcg actgggagcc atgaccttgt actgaacgaa 465301 gtaatgcttg atgagaataa gctggtggaa ctgcttcaag ggcctcgtgg agctaagccg 465361 aatggctggc tgcttcacat tcctgcgatt tatcttggtg tggctcaagc tgctcgtgac 465421 tatgcagtgc aatttgcatc tgagtattct ccaaacagct tgaatggacc gatcaagaat 465481 gtcccggccg tacagcaaag aacaggcgaa atggagcttg aactgctcaa tgccagacac 465541 tttcttttcc atatcgctca attgtatgac gatccggtgc ggcgtccaca cttgaccagc 465601 gagctcggtg cggcgaaaca tatcgtcaca aacgctgcgc tgtctgttgt tgataaagcg 465661 atgagaattg tcggggccaa aagcctggaa cgaaccaacc cgcttcagcg ctattaccgt 465721 gatgtgcgcg ccggtcttca caacccgccg atggatgacg ccgtgataca caagctggca 465781 gctgaagcgt ttgagtcata aaaaaaagag ccttaccggc tctttttatg tattgttttg 465841 ctcttgcaga tttttttgat gcttgcggtc gatcctgtca taaataacgt tcatcagctt 465901 tggattgccc ataatcgcct ctttgttttc ctggatcagc tgttggtaag ttttcacttt 465961 acgcttcggc atgctccggc gccctcctga catgtttgta ttcactttct aactccgtca 466021 gcgacaattc atacagatga cgctttgact ttttgtatat accattctgt attaacagat 466081 gaatgagctg tttttttctg atttctgcag actgaggtgt cattgtgtca ccaacctcca 466141 atcaaacgat attgataatc attatcaatt aacttcagta tacaatgtcc gcaatagcct 466201 gtaaagatga aaagagtcct attcttggcc aatttacaaa cattcaacaa atcgacaaaa 466261 agtttcccgg gcaataattt gctgtcgaaa tattccgctt cattgaacgc accctgctat 466321 ttttcatgtt ttgaaccata ctatgtaata gaatggaggc tggtattcaa tggagcggac 466381 agaaaatctg aaaaagggag aaaaaggggc gctcctcaat atttttgcat atgtcatcct 466441 tgctgttgta aagctagtta tcgggattct atatcattct gaagcgctga gagcagacgg 466501 gttaaataat ggaacagata ttgttgcgtc agtagcagtg ctgataggat tgcggatttc 466561 tcaaagaccg gctgacagcg atcatccata cggccattat cgggctgaaa caatttcgtc 466621 tcttgttgcg tcttttatta tgatggcagt cggcattgaa gtgttaatcg gcggaggaaa 466681 agcgattgcg ggcggcacaa cggaaacgcc aaatcttatc gcggcatgga cggcgttagg 466741 cagtgctgtg tttatgtatg gcatctattt atataacaaa aggctggcag cgtccattaa 466801 aagctctgcc ctgatggcag cggcaaagga cagcaggtca gacgcttttg taagtgccgg 466861 cgcgtttatc ggtgtttttt cgtcccagct gaagctgccg tgggttgatc cggtaacggc 466921 ttttatcatc ggcatcatca tttgcaaaac tgcgtgggat atctttaaag acgcttcaca 466981 ttccttaaca gacggcttcc atttaaaaga tcttgagcct tacaaacaga ccgtcggcag 467041 gatcgaaaat gtgcatcgcc taaaggatgt gaaagcgagg tatttaggca gtacagttca 467101 tatcgagatg gtgattacgg ttgatccgaa gcttacagta gaagaaggcc atggagtggc 467161 ggatgaagta gaagacaaaa taaaacatga acacgatgtc actcatgttc atgttcatgt 467221 agagcctgac gacataaaat aaggctgttt aacgaattag cttatatgtt cagataaaaa 467281 ttcagtcact tcttcaggcg ttttggcatt ggcgctgtga aggtgagctg ttttttcacc 467341 gttcttgaaa ataagcaggc tgggaatgcc cattacttgg tatttttcag ccaggtcagg 467401 aagctcgtcc ttattcagct cataccagtc gttttggttg tattcttcca aaatatcgcc 467461 gatgaacata ttcatgcgtg tgcagtctgg gcaccaatca gcataaaact ttacaatgat 467521 ttctttatca gattgaatca gttcattaaa ttgttcgttt gttgtgattt ttttcatatg 467581 tcacatctcc ttttcaatgc cattttaata taaaataaaa aggaattaca tacaaatgca 467641 ttcaacatca gcatgcccaa aaataattag atcattttcc ggtgaaaatg ataagatagt 467701 aaagatgaat tgtagtgggg ggagtatcca ttgaaaacaa gtctaggatt agtgtacgga 467761 ggaaagtcgg cagaacataa tgtttccctg cagacagctc tggctgtaat caaagcgcta 467821 aatactgaga agtttgatat acatccgatt tatataacag aaaaaggcga atgggttaga 467881 ggcgcccgtt taactgaacc tgtttcaaac gtgaaaatgc ttcaatttga gcaaggaggc 467941 agtgcttttt ctccagctgc cctgaaccag gagatgtttc cgcaggaagc gtcacagcaa 468001 aatgaagcca tcgacgtcgt attcccgctc ctccacggac cgaacggaga agacggtacg 468061 atccagggaa tgctcgagct gttgaacatt ccttatgtcg gcaacggagt gcttgcttcc 468121 tcagctggca tggataaagt tgtcatgaaa catttatttg cgcaggttgg ccttgctcag 468181 gctaaatacg cagctttcct taagaaagac tggactcgtt ctccgaaaga aagctgtgag 468241 gaggttgaac aggaattagg ctacccttgc ttcgtaaaac cggcgaacct cggctcaagt 468301 gtcggaatca gcaaatgccg aaaccgtgaa gaactgcaaa aagcgtttga gcttgctttc 468361 caatatgacc gcaaagtcgt cgttgaagaa ggaattaacg gccgcgagat cgaaatcggc 468421 gttcttggaa atgatgatcc taaatgctct gttgtgggag aaatcgcacc gaagacagat 468481 ttctacgatt acaaagcgaa atatgaggat ggagatactg atctgatgat tccggcgatt 468541 gtgactgatg aggaatacgc aacaatcagt gatatggcga tcaaagcgtt taaagcgatc 468601 gacggttcag gactcgtcag agcggacttt ttcctgacag ctgacggcga agttctgatc 468661 aatgaagtca acacaatgcc tggctttaca cctttcagca tgttcccgtt gctctggaaa 468721 gaagccggag tggaatatgc tgacctgatt gaacagcttg tggagcttgc aaaagaacgc 468781 cacgctgaaa aacaattgat taagcataca ttctaatgaa gaaggacact gccggtaaaa 468841 gggcagtgtt ttttcccgta tatacaaaag aaagagaggg accttacttg attaagcgaa 468901 cagtaaaaaa cattgccgaa atggttaaag gcacactagc aaatccgcaa tatgaacaaa 468961 cagtcattca tggagtggca accgatacaa gaaaactgga acaacatcag ctctttattc 469021 cgctgaaagg ggaacgtttt gacggccact cttttgtgga gcaggccttt gaagctggtg 469081 tagcggctgt tctttgggat cggtcagtac caaatccgcc cgagaatcac gccgtcattt 469141 tagtggacga tacccttact gcacttcagc agcttgcaaa agcttatttg caggagcttg 469201 gcacgcgtgt catcggagta accggaagca atggcaaaac gacaacaaaa gatatgattc 469261 acgccgtatt ggggacccag taccgtgtcc acaaaactgg aggaaacttc aataatcata 469321 tcggtttgcc gctgacggtt ttagcgatgc ctgaaaatac ggagatcgcc gtattggaga 469381 tgggaatgag cgccaaagga gaaattgacc tcttgagccg actggcaaac ccggatgcgg 469441 cagtgattac gaatatcggc gaatcgcata tgcaagacct cggctctaga gagggcatcg 469501 cggaggcgaa gcttgaaatc ataaacgggc ttaaagaaga cggagtgctg atttatatcg 469561 gggacgaacc gcttcttcaa aatgcataca gctgccagac gaaaacgtac ggtacgggaa 469621 cgcataatga ttatcagctt caggatgtca gccagagtga ggaaggaacc cattttacaa 469681 tcaaagggat agaaaacacg ttttttattc caatactcgg caagcacaat gtgatgaacg 469741 ccatggctgc aattgctgca ggggcttatt ttggcatcgc gcctgaggat gcggcaaaag 469801 gactgagcgg cctaaaggta accgggatga ggcttgaact catcaaaaca gacagcggcc 469861 tttcgataat caatgacgct tataatgcga gcccgacttc catgaaagct gcaattcaat 469921 tgacagaaag ccttgaaggc tacggcaaaa aaatgctcgt gctcggtgat atgcttgaac 469981 tcggcgatct tgaagaaacg ttccataaag agtgcggcgc tgtgatcagc cctgataaaa 470041 ttgaccgcgt ctttacgtac ggaaaactgg gagcttttat cgcggaaggc gccctgaaac 470101 actttgagaa agaccgcgtc agccattaca ctgagaaaaa agatctcctt caagctgtga 470161 aggaaaacgc atcaaaaggc gatttgattt tattcaaagc gtccagaggt atgaagcttg 470221 aagaaatcgt taaagattta atagagagcc cgctttcata agaaaatatt ttgcgaaaaa 470281 acgcatattg catcataaaa taacctgata tgcaaacact aatgtatgcc ggccgaaaat 470341 tatgtatatc tggccggctg cggctatgat acaatatata taggttattt cgcgatacga 470401 acatattcgt ccggactttt catcgtgacc cgaagttctc cgctggattc ttgggagcgg 470461 atggagcagc agccggcata ttcgagatgc cgatctgctt ctcatcttat tgaaaaacaa 470521 atagtgtaat ggtaagataa aacttaaagt aattcgggct ttgtatacgg atggatcctg 470581 tccttcttgt ctaaagggca gttttataag tggtaaatca cgacattact gaaacagcaa 470641 ttagaaggag tttgaataat ttgactataa cgtttcaaga ttttaattta agttctgatc 470701 tcatgaaagc aattaatcgt atgggatttg aagaagcaac accgattcag gcacaaacga 470761 taccgctcgg actttcaaat aaagacgtca ttggacaagc gcaaacaggt acaggtaaaa 470821 cagctgcgtt tggtataccc cttgttgaaa aaattaaccc cgagtctcct aatattcaag 470881 caatcgtaat cgcgccaacc cgtgaattag ccattcaagt atctgaagaa ttgtataaaa 470941 tcggacaaga taaacgtgcg aaggttcttc ctatttacgg cggacaggat attggacggc 471001 aaatccgggc gttaaagaag aatccgaata ttattgtcgg aacacctgga cgtcttcttg 471061 accacatcaa ccgccgcacc attcgtttaa acaatgtaaa taccgttgta atggatgaag 471121 cggatgaaat gctgaacatg ggattcattg acgatattga atctatcctt tcaaacgtgc 471181 caagcgagca tcagacactt ctgttctctg ccacaatgcc tgcgccgatc aaacgcattg 471241 cagagcgctt catgactgag ccggaacacg taaaagtaaa agcgaaagaa atgacggttt 471301 ctaacattca gcagttctat ttggaagtgc aagaacgtaa aaaattcgat acactgactc 471361 gccttcttga tattcagtct cctgagcttg cgatcgtatt cggacgtaca aaacgccgtg 471421 tcgatgagct ggctgaagct ctgaaccttc gcggatatgc agctgaaggt attcacggtg 471481 acttaacgca ggcgaaacgt atggttgcgc ttcgtaaatt taaagaaggc gcaatcgaag 471541 ttctagtcgc aactgatgtt gccgctcgcg gacttgatat ctcaggtgtt acacacgtat 471601 acaacttcga cgtgcctcaa gatcctgaaa gctacgttca ccgtatcgga agaacgggcc 471661 gtgcaggaaa aacaggtatg gcgatgacgt tcattacacc gcgtgagaaa agcatgcttc 471721 gcgcaattga acaaacaaca aaacgcaaaa tggaccgcat gaaggagcct acacttgatg 471781 aagcgttaga aggtcagcaa caggttactg ttgaacgtct tcgcacaaca atcagtgaaa 471841 acaacctgaa cttctacatg acagcggcag ctgagctgct tgaagatcat gatgcagtaa 471901 cagtggttgc ggcggctatc aaaatggcta caaaagagcc agacgacaca ccggttcgct 471961 taacagacga agcgccgatg gtcagcaaac gctacaagaa ccagcgctct tctaaacgca 472021 gagacggtca aggcggcggc taccgcggcg gaaaagggaa aagcaacaac cgttcttcct 472081 atgacaaaaa gcgttcaaac gatcgccgtt cttcaggtga cagacgccag aaaaaatctt 472141 actaatttga tcgattcaga gcccaaaaca tgatgttttg ggctttttta tgttcgtgat 472201 ttgttattca gcaaactttc agctgacgga agccattttt ctctgtatgc ttaagaatga 472261 aacctttctg taaaagagac gtataaataa cgacgaaaaa aagggaggta ggtatttttg 472321 agagagcagc caaaaaacca aatcagtcca gacggattaa aggtttggcg acttcaagag 472381 atcatcatat ccgctgtttg cttgcttatt gtcattgcag ttgcagtgtt aagctattat 472441 tttcattggc cgtactggat cagcggcgtg ctcggcgctg tttggctgct gggatcgatt 472501 gtgacggtct ttatcattcc gaaggtccgt cataaggtgt ggcgatatga agtccatgaa 472561 catgaaatag atattcagtc aggtattttt gtggtgacac gtgtgattgt tccgatggtc 472621 agagttcagc acgtcgatac gtcacaaggg ccattattaa aaaaatacaa cctggcaacg 472681 gtgaaaattt ccacagccgc gaccgttcat tcgatccccg ctttagagat ggaggaagcg 472741 gatcggctaa gagactccat ttcccgtctg gcgagggtga ctgacgatga tgtctgaacc 472801 gaaacgcctg cacccggtgg cagtcatttt gaatttatgc cataccatta ttcaaacgat 472861 aaaaaatatc attctgccat tcttttttgt gtatattgtc aattcaaacc atactgtccg 472921 tttttacgga gccattgcgc tcggtgtgct gttcatctgg cttgtagcgg caagcattat 472981 caaatggaga aggtttacct atcgaattga agatgatgaa tttagaattg aagaaggctt 473041 atttgttacg aaaaaacgat acatatcgat tgatcggatt caaacaatga atacgagcgc 473101 gggccttgtc cagcaaatct ttaagcttgt gaagctgcaa attgaaacag caggcggagg 473161 caaggaggca gaagccgttc tttctgctat ttctgttgaa gaagcggaac gcatcaaaga 473221 agctgtcttt aagaaaaaag cgcaaagacg agaaaatgaa cttgatgaag aacggcttga 473281 agctgaagag gagttggatc cgtccgttga ggtgcaagag cactatcgca tgaacgcgaa 473341 agaattgctc atggccgctt ctacctccgg cggaatcgga gtcattatct ccgctgtatt 473401 tgcacttatt tcccagcttg atgaagtgct gccgatggat tggttattcg ataaattttc 473461 cttccttcag cacgccagca tcggtattta tgcggtactc atttttatcg gtttatttat 473521 cgcctggatt ttcagcatcg cgggcatgat gtttagatac gcgaactttc aaatcataaa 473581 aaaagagcag gaactggtga tttcaagggg aattattgaa aaacatcaag tcacgattcc 473641 gctgcgaaaa atacaagcca ttaaaatcaa agaaaatatc attcgccagc ttttcggctt 473701 tgtaacggtg tccatcgtca gcgcaggagg cggcgaccgg gaaaaagaag aaggcgcttt 473761 gaccattctc tttccaatga ttcataaaaa aaagcttccg cacatgctcc gaacatttac 473821 gccggaatac acgctggaag aaaactgccg ccgcctgccg cggcgcgcgt tgaaacgcta 473881 tttgttccgt tctgtcattt tttcactctt tttgatcatc ccgttatgta tcttctttca 473941 gccatggggc tatctgtcag tgatcctgct gccgatagaa ttgctcttcg gctatctcgc 474001 gtataaagag gctgcatgga cgatcaacgg ggaccgtctt cagctgacgt ctagatttat 474061 aggcagaaca accgccattg tactgaaaaa acgaatgcag gtctgcaagt tcagccaatc 474121 ctatttccaa aagaaaggcc gcttgtatac catttctact tcggtgaaat catcgagcca 474181 tatggaagag ttaacggtga gggacgtagg tgaagaggat gcagccttca ttttaaagtg 474241 gtactcatat gaaaaagcgg acggttaata ccgccgctcc agcgtgtcgg caaaccctcg 474301 cattcgttgt caggactgcg cttcggtgct caatgcgaag tggatcaacg gctaaattct 474361 caggcgtcct gcctaaacgc cgtcgtcatc acatcctgtg aaagtccgct cctatgctcg 474421 tccttcctag acttcatggg ttttcaatca cgctgaaaag atgacaaaat cctaaaatga 474481 aaaccatttt aggattttgt caacaatctg aagcggcggt taataccgcc gctctttttt 474541 ttgcacgcat aaaaacgaaa gaagaaaccc gccgcatagt ccaaacaaat gggccatcat 474601 gttaatattg gagttgataa acgacatgag aacggcaaat gcgagcagtg tgatgatcat 474661 tttggaatgc tcctgcccaa ttaactcatt gcgaaaaaga accataaaca ggtatacgcc 474721 aaatagcccg aaaatggcgc ctgaagcccc gacatgcacg taatcaagcg gctctgtaac 474781 ataagtgccg atattgccga tgatgccgga gccggcgtat acaagaagga aacgcgcttt 474841 tcccagcatg cgttccaaag ccggggcaaa taaaaagatg gacatggaat taaacagcag 474901 atgtgtgaaa ccggcgtgca gcaaaatcgg tgtgataagc cgccaccatt caccgtttgc 474961 gacacctaga ttatagcctg tgacggtatc cctccataac acgactgaat gggcaggaag 475021 tgaaaaaaac agccagagaa cagcttgcaa agccaatata aaggtgacaa cggggtaaag 475081 cctgataaat gtttgaaaat tttcagtccg tataaacatt ccgagcccct tttcttcatt 475141 ttggtatatc tatagtaaca cgtttatgag acaaaccatt taaatagtac gtacgcaaag 475201 gaggttatca tacatgattt acggcattgg gctggacatt accgagctta aacggatcgc 475261 ctctatggct gggcgccaga aaaggtttgc cgagcggatt ttgacgcgaa gcgagcttga 475321 ccaatactat gagctttcag agaaaagaaa aaacgaattt ctcgcgggca gattcgcggc 475381 aaaagaagcg ttctcgaaag catttggcac cggcattggg aggcagctca gctttcagga 475441 cattgaaatt aggaaagacc aaaatggcaa gccctatatc atttgtacga aactgagcca 475501 ggccgccgtt cacgtatcga tcactcatac aaaagaatac gctgccgcgc aggttgtgat 475561 tgaaaggttg tcaagctagt ctgcatatta gggaaacccc actcatatat ttgatagtgc 475621 attaagggag acaagttgtt tgaggctttt atggtacgca tctgttctgc ctaaacgtgt 475681 accgagcgta ccgttaaagt caaacaagcg atttcttcct tttacatcaa ttgagaaaaa 475741 ggggttgaaa aaggtgagaa aaagctttgt tttgctttta acgggactgc ttgctgttct 475801 tattctttct gcctgcgggc aaaaaacaca gcaagatatt gtggccgggt tagatgaaaa 475861 ggcgaaagaa tacacctcgt acaaagcaaa agcgaaaatg accatcgaga cagggagtga 475921 gcctcaagta tacaatgtgg aaatctggca caaaaagccg tctctgtaca gggtttattt 475981 agaaaatccg aaaaaggacc aaaaccaagt cattttacga aatgaaaacg gagtattcgt 476041 tctcacgccg tctttaaata agagcttcag atttcaaagc gattggccga acaacagcag 476101 ccaggtttat ctgtttgaat cgctcgtaaa ggatgttcaa aacgattcgg atgcagtttt 476161 cacagcgaaa gaaaagaaat acgtatttga aacaaaaaca aactatcagc ataacaaaat 476221 gctgcccacg caagaaatca catttaacaa aaaagatatg agcccgtcat ctgtcaaagt 476281 gatggatact gaccggaaag tgatggtcaa agtagaattc agcagctttg aatttaataa 476341 acaatttgat aaagaatcat ttgatgaaaa gaaaaatatg accctttctc aaatggatgt 476401 cgccacaagc gcaaagcctt ccgatacatt tgcggtcaaa acgccgctgg aactgccgct 476461 tggcgtcaag ctgcttgaag aaaaagatat atctactgaa gacgggaagc gcatcatcat 476521 gacgtacgga ggagaaaaat catttacgtt aattcaggaa aaagcccaga ttgccaaggc 476581 ttcctcctcc gttacgctga acggcgaacc ggtaaatctc ggctacacca tcggcgccct 476641 gtcggatgca tcattatcat ggacatatga cggcgtagat taccttctct cttctaaaga 476701 tctttctaaa gaggaaatgg tgacagtagc gaaaagcatg cagggacaat catcgaaata 476761 accgccaaag gccaaacatg atttggcctt tttttcgtta gacatcgttt ccctttagcc 476821 tttaatttta gtatgatatg taaatgatat tgaataaaag ctaggaagtg tcgtaatgag 476881 cacaaaacct ttttacagag atacgtgggc ggaaattgac ttgtccgcga taaaggaaaa 476941 tgtcagcaat atgaaaaaac atatcggtga acatgtccac ttgatggcag ttgtgaaagc 477001 aaacgcctac gggcatggtg atgcagaaac agcaaaggct gctcttgacg caggtgcttc 477061 atgcttggcc gtggccattt tggatgaagc gatttcactg cgcaaaaagg gattgaaggc 477121 gcctatattg gtgcttggcg cggttccccc ggagtatgtg gcaatcgctg ctgagtatga 477181 cgtgacctta acaggttatt ctgttgaatg gcttcaggag gcagcccgcc acacgaaaaa 477241 aggttctctt cattttcatc tgaaggtcga tacggggatg aacagacttg gtgtaaaaac 477301 agaggaagaa gttcagaacg tgatggcaat tcttgaccgc aaccctcgtt taaagtgcaa 477361 aggggtattt acccattttg cgacagcgga tgaaaaagaa agaggctatt tcttaatgca 477421 gtttgagcgc tttaaagagc tgattgctcc gctgccgtta aagaatctaa tggtccactg 477481 cgcgaacagc gccgctggac tccggctgaa aaaaggcttt tttaatgcag tcagattcgg 477541 catcggcatg tatggccttc gcccgtctgc tgacatgtcg gacgagatac cgtttcagct 477601 gcgtccggca tttaccctgc attcgacact gtcacatgtc aaactgatca gaaaaggcga 477661 gagcgtcagc tacggagccg agtacacagc ggaaaaagac acatggatcg ggacggtgcc 477721 tgtaggctat gcggacggct ggctccgaaa attgaaaggg accgacatcc ttgtgaaggg 477781 aaaacgcctg aaaattgccg gccgaatttg catggaccaa tttatggtgg agctggatca 477841 ggaatatccg ccgggcacaa aagtcacatt aataggccgg cagggggatg aatatatttc 477901 catggatgag attgcaggaa ggctcgaaac cattaactat gaggtggcct gtacaataag 477961 ttcccgtgtt ccccgtatgt ttttggaaaa tgggagtata atggaagtaa gaaatccttt 478021 attgcaggta aatataagca attaacttac ctaaatggag aattcataaa acagctttgc 478081 ttgaagagtg aataatggta tcattatcac tggatggata aaagagtcgt atccgtaagt 478141 ttggtggagg tgtatgtttt ttgtctgaat ccagcgcaag aaccgaaatg aaaatcagct 478201 tgcccgaaaa cctagtagct gaattggatg gtgtagcgat gcgggagaaa cgaagcagaa 478261 acgaactgat atcacaagca gtgagagcgt atgtcagcga acgaacaact cgtcacaacc 478321 gtgatttgat gagacgcggc tatatggaaa tggcgaaaat caacctgaat atttcttctg 478381 aggctcactt tgcggagtgc gaggctgaaa cgacagttga gcgcttagtc agcggaggat 478441 aatcatttga ttgtgaaacg cggcgatgtt tattttgctg atttatctcc tgttgttggc 478501 tcagagcaag gcggggtgcg cccggtttta gtgatccaaa atgacatcgg aaatcgcttc 478561 agcccaactg ctattgttgc agccataaca gcacaaatac agaaagcgaa attaccaacc 478621 cacgtcgaaa tcgatgcaaa acgctacggt tttgaaagag attccgttat tttgctggag 478681 caaattcgga cgattgacaa gcaaaggtta acggataaga ttactcatct ggatgatgaa 478741 atgatggata aggttgatga agccttacaa atcagtttgg cactcattga tttttagaca 478801 tatttgcagg ttgctcaaat agagcaactt tttttgtttt caaaaaacat aaacgatata 478861 atagtgaaat aacgaaaaaa tatgttgttt tttattggga ggtaagcgaa tttgatgtcg 478921 aaccagactg tataccagtt cattgccgaa aatcaaaatg aactgctcca actgtggact 478981 gacacactaa aagaattaag cgagcaagaa tcctatcagc tgactgacca agtgtatgaa 479041 aatatatcta aagaatatat cgacattctg ctgctgtctg ttaaggacga aaatgctgct 479101 gaaagccaaa tcagcgaact ggcgcttcga gcggtccaaa tcggactgtc tatgaagttt 479161 ttggctactg cacttgccga attctggaag cgtctctaca cgaaaatgaa tgataagaga 479221 ttgccagatc aagagagcac ggaattaatc tggcagattg atcgcttttt cagcccgatt 479281 aacacagaaa tttttaatca atactcaatc tcatgggaaa aaacagtatc cctgcaaaaa 479341 atcgcgctgc aagagctgtc tgcgccgctt atcccggtgt ttgaaaatat cactgtgatg 479401 cctcttgtcg gaacaattga taccgaacgc gcgaaacgaa ttatggaaaa ccttcttaat 479461 ggcgtcgtca aacaccgttc ccaagtcgtg ctgattgaca ttacaggtgt ccctgtcgtc 479521 gatacgatgg ttgcccatca tattattcag gcatcagaag ctgtaaggct tgtcggagca 479581 aaatgcctgc tggccggaat ccgtccggaa attgctcaaa caatcgtcaa cctggggatt 479641 gatttatccc aagttataac taagaatacc ctgcaaaaag gaattcaaac agcattggaa 479701 atgacggatc gaaaaatcgt ttcattgggg gaataacatt ttgagacatc cgaaaatccc 479761 gatcttgaaa ctgtataatt gcttattagt gtccattcag tgggaacttg atgaccagac 479821 agcattaact tttcaagaag acttattaaa taaaatatac gaaacaggtg ctaacggagt 479881 cgtcattgac ctgacatctg tggatatgat tgattcattt atcgcgaaag tgctggggga 479941 cgtcattaca atgtctaagt taatgggggc taaagtcgtc ttgaccggca ttcagcccgc 480001 tgtggcagtg acgctgattg aacttggaat cgcgcttgag gaaatcgaaa ctgcgctcga 480061 cttagagcag gggcttgaga cattgaagcg ggaattgggg gaatagcgaa tgaacgacca 480121 atcctgtgta agaatcatga cagaatggga tattgtggcc gccagacagc tgggacgaaa 480181 cgttgcgaaa gaactgggtt tcggcacggt agaccaggct agaattacaa cggctatttc 480241 agaattagcc aggaatattt atttatatgc cggcaaaggg cagattggaa ttgaacaggt 480301 cgcagacaga ggaaaaaaag gcctgaaaat catagcggaa gaccaagggc cgggaattcc 480361 tgatatccga aaagtcatgg aagacgggtt ttcaacgtct ggaggacttg gtgcgggact 480421 tcccggggtc aaaaggctga tggatgaatt cagcttaaat tccgtagcgg gggaaggaac 480481 agagatacaa gccatcaaat ggcttcggta ggaggtaaga acgtggattt tagggaggtt 480541 attgagcagc ggtatcatca gctgcttagt cgatatatag ccgaattaac agaaacatct 480601 ttatatcaag cccaaaaatt cagccgaaaa acaatcgagc accaaattcc tccggaagaa 480661 atcatcagca ttcacagaaa agtgctgaag gagctgtatc caagtctccc ggaagatgtg 480721 tttcattcgc tggatttttt aatagaagtc atgattggct atggaatggc ttatcaggag 480781 catcaaaccc ttagagggat acagcaggaa atcaaatcag aaattgaaat cgcggcaaat 480841 gtccagcaga cgcttctcgg aactaaagtt cctcaggagg aagcgctgga tatcggcgcc 480901 atcagtgttc ccgctaaaca gatgagcggt gattactacc actttgtcaa agacaaggaa 480961 tccatcaata tcgcaatcgc ggacgtgatc ggaaaaggca ttccagcggc tttatgcatg 481021 tccatgatta aatacgcaat ggactctttg ccggaaacgg gcatacaccc ttctcaagtg 481081 ctgaaaaatt tgaatcgtgt tgttgaacaa aacgttgatg ccagtatgtt tattacgatg 481141 ttttatgcga attacaatat ggacaagcat caatttacat atgcttcagc gggacatgaa 481201 ccgggattct attattctca aaaagacaac acgttttacg atttagaggc caaaggactc 481261 gttctcggca tctcgcagga ctatgactac aaacaattcg atcagcatct ggaaaagggc 481321 gatatgattg ttttattttc tgacggcgtc acagaatgca gaacggaaaa cggtttcttg 481381 gagcgtcctg atctgcagaa gctcattgag gaacatatgt gttcctctgc gcaggaaatg 481441 gtcaaaaaca tttatgacag cctcctcaaa ttgcaggatt ttcagcttca cgatgatttt 481501 acgttaattg ttttgcggag aaaggtttaa cgtctgtcag acgagggtat aaagcaacta 481561 gtgatttgaa ggaaaatttg aggtgatacg aatgaatata aatgttgatg tgaagcaaaa 481621 cgagaatgat atacaagtaa acattgcagg agaaattgat gtatactcag ccccggtgct 481681 tagagagaag ctcgttcctc tggcagaaca aggagctgac ttaagaattt gcctgaaaga 481741 tgtcagctac atggacagta ccggattggg cgtttttgta gggaccttta aaatggtgaa 481801 aaaacaaggt ggttcgctga aacttgaaaa tctttctgaa cggctgatcc gactgtttga 481861 cattacaggc ttgaaggaca tcattgatat ttctgcaaag tcagaaggtg gagtgcaatg 481921 aagaataatg ctgattacat cgaaatgaaa gtgccggccc aacctgaata tgtgggaatt 481981 ataagactga cgctgtcagg ggtcgcaagc agaatgggct atacgtacga tgaaattgaa 482041 gacttgaaaa tcgcagtcag tgaggcgtgc acaaatgcgg ttcagcacgc ttacaaagaa 482101 gataaaaatg gggaagtgtc aatacgattc ggtgtgtttg aagaccgttt agaggttatt 482161 gtggcggatg aaggagacag ctttgacttt gatcaaaagc agcaggatct agggccgtac 482221 acaccttcgc acacagttga tcaattatca gaaggagggc tcggtctata tttaatggaa 482281 acgctcatgg atgaagtcag agtgcaaaac cactccggcg tcaccgtagc gatgacaaag 482341 tatttaaatg gggagcgagt tgatcatgac acaaccatca aaaactacga aactaactaa 482401 agatgaagtc gatcggctca taagcgatta ccaaacaaag caagatgaac aagcgcagga 482461 aacgcttgtg cgggtgtata caaatctggt tgacatgctt gcgaaaaaat actcaaaagg 482521 caaaagcttc cacgaggatc tccgccaggt cggcatgatc gggctgctag gcgcgattaa 482581 gcgatacgat cctgttgtcg gcaaatcgtt tgaagctttt gcaatcccga caatcatcgg 482641 tgaaattaaa cgtttcctca gagataaaac atggagcgtt catgtgccga gacgaattaa 482701 agaactcggt ccaagaatca aaatggcggt tgatcagctg accactgaaa cacaaagatc 482761 gccgaaagtc gaagagattg ccgaattcct cgatgtttct gaagaagagg ttcttgaaac 482821 gatggaaatg ggcaaaagct atcaagcctt atccgttgac cacagcattg aagcggattc 482881 ggacggaagc actgtcacga ttcttgatat cgtcggatca caggaggacg gatatgagcg 482941 ggtcaaccag caattgatgc tgcaaagcgt gcttcatgtc ctttcagacc gtgagaaaca 483001 aatcatagac cttacgtata ttcaaaacaa aagccaaaaa gaaactgggg acattctcgg 483061 tatatctcaa atgcacgtct cgcgcttgca acgcaaagct gtgaagaagc tcagagaggc 483121 cttgattgaa gatccctcga tggagttaat gtaatgatcc aggttgaaga aaacgagcat 483181 attcaaactc tagtatatca actgaataaa gaagggaaat cgatttgcgg tgacagtttt 483241 tttatgaaag ctgatgataa ggagttaatt tgcgcggttg ctgacggact gggaagtgga 483301 tcacttgcta acgaatcctc tgcagccatc aaagacttag tggaaaacta tgcgagtgaa 483361 gacgtagaaa gcattatcga acgctgtaat caggcgatga aaaacaaaag aggcgctaca 483421 gcatctatcc tgaaaatcaa ttttgagcaa aggcagttta cgtactgctc tgtcggaaat 483481 gtacggttta ttctgcattc cccgtctggt gaaagctttt atcctctgcc gatttcgggc 483541 tatttatcag gcaagccgca aaaatacaaa acgcacaccg ccacctatga aaagggttca 483601 aagttcatta tacatacaga tggactcaac gtacctgata tccgctccca tttgaaaaaa 483661 ggccaatcgg tagaagaaat atcgaattcg ctgaaaatgt atacgacatc gagaaaagat 483721 gacctgacct atattctcgg acagctgtcc taaaaaacca gaaaaagaag ctggacatcc 483781 ggcttctttt ttttgcggtt gactattaat aagtgcgctt attatactta ataagtgaac 483841 ttatcattct gggagcttat gggatgtgga attatgaata cacagcgata gctgatgtgg 483901 atgtgggaaa acctggaact gttatcagga aacagaaaca atggatcaat gggagacggg 483961 tattgcatca gattctttga aaggacaatt tcaaaatgga acggaaggaa cattgcttct 484021 gcaaggaaaa acaattctct tatggcttga gcatgtggag aaacatcggg cgttttctgt 484081 catggtcaac atgcccgcat agcaatgtaa taatggagtt ttttcacgtg cttcaaaagc 484141 aaaaagaaga tttgtgtatc acatatggaa ttgtattaga aggcgctgaa gcaaaaaagt 484201 ggggagaaat cattgggact gaactgtcta aagacatgcc gacggctgtc agcaggcttg 484261 tccatcttta cggaggagtg ataaaatgaa cacaaattac tggatcggcg ttgtgtcaga 484321 gcaacatgta ttaaaaggcg ctgccggcgg ttttgcacag ctgtgccatg gaaaaaaagc 484381 cccgctcgcc aaaatgaaag agggagattg gctgatttat tattctccga gagacgcata 484441 tccagacggc aaactgctgc gaagctttac tgcgatcggc aaagtaaaaa gcggaaacat 484501 ctatccgtat caaatggctc cgaattttat tccataccga ttagatatag actattatcc 484561 atgccataaa atcggttttt acgacattaa atcaaagctt gaatttgttc aggaaaccaa 484621 gcatcttggc tttttatttc gcagaggaca ctttgaaata agcaaaaaag attttttgac 484681 aatagcacaa gcgatgggag ttaacataag tggaatggca ctctaaattt agcggtccga 484741 acacaagccc gggcttttta ttatggcagg ccacgcaaag ttggcagcgg aaagtaggaa 484801 aagcattggc tgagtttgac ctgacccacg ttcaatttgt tctgctgacc tcgtgcaagt 484861 atatgattgc tcacggagaa accgtcacgc aaaaaaaact tgcaagcttc agccagacca 484921 atatcatgat ggtttcggag gttgtgcgga cgcttgagaa aaaaggattt atcgaaagaa 484981 gcaaaaatcc ccaggataaa agagaggtcc tcctgtctct tacagaaata ggaggagaaa 485041 aagtaacagc ggctttgcca attgttgaga agattgatca agccttcttt gcagctgcga 485101 tgaaaaaaga gaattttctg agcggcttac aggaactatt gaaacatgag taaagatacg 485161 ggcagcgcca gctgtctttt tttatgtgtt tttttcggtt tttgatacac tagagaaaga 485221 acgacaaaat tggaggcttt ggttacatgg aaacgtcagc ccttttaaaa cagcaaattg 485281 cgaaagaaat aggtttatca caaaaacacg ttgaaagtgt catccgcctg cttgaggacg 485341 gcaatacagt cccgtttatt gcccggtatc gaaaagagca gacgggttca atggatgagg 485401 ttcagattca gacgatttct gaacgctggc aatacataca aaacctgaat cagcgaaaag 485461 aagaagtcat caggctgatt gcagagcagg ataaactgac agataatcta aaacgtaaaa 485521 tcgagcaatc ggtgaagctt caggaagtgg aagaccttta ccgcccttat aaacaaaaac 485581 gtaaaacaaa ggcgacagtc gccaaaagca aaggccttga gccgcttgcc gactatatcc 485641 tgacacttcc ccaagatgat catctggcag caactgcaga ccaatacatc agcgaagaaa 485701 aagaagtgtt cacacgagaa gaagcgattg aaggcgccaa gcacattatt gcggaacaaa 485761 tctcagacga gccgaccttc agaaagtgga ttcgccagga aaccttcaaa agaggaacca 485821 ttaagtctgc agccggaaag tcggcagaca ccgatgagaa aaatgtgtat gaaatgtatt 485881 acgagtatga agagccaatt gcaaaagttg ttccgcatag ggtgctggca atgaaccgcg 485941 gcgaaaaaga agacatttta aaggtagcga tcgaaccgcc tgcggatcac attaaggcgt 486001 atttagaaaa acaaatcatc aaaaatcgct caacatccgt aagagagatt ttgcaggaga 486061 caattgaaga cagctataaa aggctgatcc agccggcaat cgagcgtgaa atcaggaaag 486121 agctctcaga aaaagctgat gaacaggcga ttcatatttt ctcagagaac ttgagaaagc 486181 ttcttttgca gccgccgatg aaaggcaaaa ccgttctcgg tgttgaccca gcctttcgaa 486241 ctggctgtaa gctcgctgtg tcagatgaga ccggaaaagt cttgaaaatt gatgtgatct 486301 atccgcatgc gccagtcaac aaaacaaaag aagcccatga aaaagtgaaa aagattcttg 486361 agcagtatca agtcgagatg gtggcgatcg gaaacggcac agcatccaga gaaacagagc 486421 aattcatcgt caatgtactc agagacatgc cgcgcaaaat ttattatgtg atcgtcaatg 486481 aagcgggagc aagcgtctat tcggcttcag agcttgccag agaagaattc cctgacctta 486541 aggttgaaga gcgcagtgcc gtatctattg ctcggagact tcaagacccg ctcgcggagc 486601 tcgttaagat cgatccgaag tctgttggtg tcggacagta tcagcatgac gtcagccaaa 486661 aacgcttaaa tgaatctctg cggtttgtcg tcgaaactgt cgtaaaccag gttggagtaa 486721 acgtcaacac agcctccgcc gcgctgcttc aatatgtagc tggattatcg aagtctgtag 486781 caggcaacgt tgtcaaaaaa cgtgaggaaa tcggaaagtt ttcaaatcga aaagaactga 486841 aggacatccc aaggttaggt gcgaaaacct atgagcaatg tatcggtttc ttaagagtgc 486901 aggaagggac agagcctttg gatagaacag gcatccaccc ggaaagctat aaagaaacaa 486961 aagcactttt gaaaaaactc ggactttcaa cagaacatat cggcacggcg gaattgaagg 487021 acaaaatcaa tcagctggcg ctctctgaaa cggcaaaaga gctgggaatc ggcgaaatca 487081 ctctgaaaga catttgtgaa cagctgacaa ggccggaacg cgatccacgc gataaggtgc 487141 ctaagccttt gctgaaaaca gacgtccttc agctggaaga tttgaaagag ggaatggaac 487201 tgcagggcac cgtgcgcaat gtagtggact tcggagcgtt tgttgatatc ggagtcaaac 487261 aagacgggct tgtgcatatc tcaaaattga gcaatcaatt cgtcaagcat cctcttgatg 487321 tcgtatctgt cggcgatatt gtgacagttt gggttgacgg cgtagatgta caaaaaggca 487381 gagtatcgct gtctatggta aaataaaagc actgcttacg agcagtgttt tttcctatag 487441 aaataccagc attgattcag cagtttaatt tggtaattat ctttttcaag gaacgctttt 487501 tgcatctgct ttttaagcca atttggcata ggctcattcc tcctcagctt ttatcataag 487561 agggacagtg attaccatat tgtatgcgaa cggtgaattg tcccgttcaa tgttttttaa 487621 gtgaggtgca ccatggataa caaagagctt caaaagctga cagaggatat ttctgaaaca 487681 tattttaaaa agccgttccg ccatcaggcg ctttttaatg accggcttaa aaccactggc 487741 ggcaggtacc tgttaacctc ccataacatt gaattgaaca gaaaatattt gattgaacac 487801 ggcagggagg aactgattgg catcatcaag cacgagctct gccattatca tcttcatctt 487861 gaaggaaaag ggtacaagca cagagacaga gattttagaa tgctattgca gcaggtcaac 487921 gcgccgaggt tctgtacacc ccttaagaaa aaagcggaaa acaaaaaaac ttatatgtat 487981 atctgtacga cctgcggcca acagtatata aagaagcgcg ccatgaaccc tgacagatac 488041 agatgcggaa aatgccgcgg aaaaataaaa agaatttttt cgtgaaaaag gttgacgaat 488101 atggcaagcc tatgttacat tataaaagtc gtcacgagag ataaataaaa acatttacct 488161 cttgacactg caaatcaagg ctgatataat aagtcttgtc tcattattcc acagtagctc 488221 agtggtagag ctatcggctg ttaaccgatc ggtcgcaggt tcgaatcctg cctgtggagc 488281 catattggag aagtactcaa gtggctgaag aggcgcccct gctaagggtg taggtcgcgt 488341 aagcggcgcg agggttcaaa tccctccttc tccgccataa gatttcgata taagttctca 488401 accatcggcc cgttggtcaa gcggttaaga caccgccctt tcacggcggt aacacgggtt 488461 cgaatcccgt acgggtcatt ccatttcgtt gggctatagc caagcggtaa ggcaacggac 488521 tttgactccg tcatgcgttg gttcgaatcc agctagccca gccattttta tttttgaaat 488581 ctaatagtaa gagccattag ctcagttggt agagcatctg acttttaatc agagggtcga 488641 aggttcgagt ccttcatggc tcaccatttg tctttttgcg ggtgtggcgg aattggcaga 488701 cgcgctagac ttaggatcta gtgtcttacg acgtgggggt tcgagtccct tcacccgcac 488761 tttatttaca aagtgcacgc aaatctgttt tactaggtta agagcctact aaaccagcac 488821 aacacaattt aatgatcacg cggtcgtggc ggaatggcag acgcgctagg ttgagggcct 488881 agtgggtgaa taacccgtgg aggttcaagt cctctcggcc gcatctcaat aataccaagg 488941 gtttaaccac ctttggtatt atttttttgt gtggaaaata cggctatggg agaagacttg 489001 ctcaccaaaa ctcaccagtt acttaaagta agtcatccaa acggtcggcg gttccttctg 489061 tttattagga aaaagatatc cgttcattgt aaaagaaacg aaccatgtcc tattcgttca 489121 aaaaaactaa agggtgatac atattataca tgattaatat gtatcaccct tttctttctt 489181 gttcaacaat cgcgcttgag gagaacataa gctaatacaa ctgactcgat ttctaaagtt 489241 gctccattct ttttttaaac aactcatcca caacctgttt taaaatctcg tacgactgaa 489301 tttccttgct caattcgtaa atattagata acacaattaa ttcatctgcg tgatacattt 489361 gttggaaatc aattagttcg cgacgaattg tttctcgatc acccatgatt gtatacccca 489421 gtcgactgtg gagaatttct aattcaaact gtgataacga ttctaggaag ttttcagtgg 489481 gtggaataag cttacttaaa ttatttgtat aaatatcaat atacacctgc aaatgacttg 489541 cagaaataaa agatgcctcg tctatagatt ctgctgcaat cacattaatg caagcgatca 489601 cataaggttc ttgtaaataa gaagacggtt ggaaattttc tcgataaata gagagcgctt 489661 cttccatcga atggggtgaa aattgagcgc caaatgcata gggtaaacca agctttgcag 489721 caatttccgc tgaatccgtt gaggatccta acacaaaaac aggcacatgc gttccaatac 489781 ccggataagc gcgaacctca ccctgtacac tcttatcccc gacaaaacgc aaaatatcat 489841 ttacttctct ttcaaagaaa aacactccat tatggttgga acgacgaatc acatcggccg 489901 ttttttgatc cgttccgggt gcgcgtccta atgccaaatc tacacgattt ggatataatg 489961 tttcaagtgt tccaaattgc tccgctacga ttaatgggga atgatttggc aacataatac 490021 cccctgaacc tacgcgaatg tcttttgtat ttgctaatat atgttgtaca attgatacgg 490081 ttgctgcact tgcataagcg tcgtgattat gatgctctgc aaaccaaatc cgtttatagc 490141 ccatattatc tacagcttta gctaatgaca ctgcagaatc aatcccttgt ttcattgttt 490201 ctccttgtct taatggagca actgataaaa cagatatatc aaattttttc ataatttcac 490261 ctctaaaata atgaacttat acaagatcaa tggaaaaaac attttgaaaa attgtttcat 490321 attaaatggt gtccattcct ctttgatttg catgcaaata aatatatact ttctcaaacg 490381 atcaatacat aggcaaaata aagttatttc acaatttcac tttactttta aagttttaag 490441 caaacataaa aaaatgttca gtgaacaaaa tatgtaaaat acatcttatt tttcagaaag 490501 gatacaagaa aatgattgat gaaatagata aaaaaatact tgatgagctg tctaaaaata 490561 gtcgccttac aatgaaaaaa ttaggggaaa aagtacatct cactgcacca gcaaccgcat 490621 caagagtagt aaagttaata gacaatggca taataaaagg atgtagtatc gaagtgaatc 490681 aagtgaaatt aggcttctct atacatgctt ttcttaatat ttatatcgaa aaaatccatc 490741 atcaacccta tttagctttt atagaaacac aagataacta tgtaataaac aattataaag 490801 ttagtggaga cggttgctat ttgcttgaat gtaaatttcc ttcaaacgag gtattagatc 490861 aatttttaaa tgacttaaat aaacatgcaa actataaagt gtcgattgtt attggtaaat 490921 agttaacttt ataaaacgga gatgtgcggt catataacat gatatatatg ctctaaaaaa 490981 gccctaggtt ggatatggaa tttaccaagc tggggccttt ttatacatta taataacaag 491041 cgcattattc atcagacatt aatgaagtat tataatgctt ttttacttcc ttaatagaca 491101 aataaagctg atagtttcca tacttcaata aatcattcag aaggtgattt aaaacttctt 491161 gtgaatgaac cgttaccttc agaagataac atgcatctcc cgaaacacga tgagcttcgc 491221 taatttcatt acgagtagca ataaatttca ataaatcatc atgcatatat gcattcatga 491281 aaaagaagac aaaggctgta aaagaaaacc ccatcttcaa ttcatcaacc acaatcgaat 491341 atgctttaat gataccgtta tcctccattt ttttgatgcg attgcctacc gcttgtcctg 491401 tcatatgaat tttttcaccg atttctttcc attgtatccg agcattttta tttaataatt 491461 ggagaatttg aaaatcaatt gaatcaattt gcatagtaac tcctttcaca gtgaaaaagt 491521 tttacaaaat agtatttcat gagaccatcg aaaattcaat ggaaattata tatccttata 491581 cagtataaaa attttaagag gtgaaaaaat gacaacagct ttattagtga ttgatattca 491641 aaatgattac tttccaaatg ggaagatggc tttaacaaac ccagagaaag cagcacaaaa 491701 tgcggctaaa ctactttcac actttagaaa cacaggcgca cctgtctttc atgtacagca 491761 tatcacagaa ggtaacatcg ctcatttttt ccatccaaat acagaaggtg tcgaaattca 491821 tgagtcagta cgtccattag agaaagagac agtcattgta aaacatatgc cgaatagctt 491881 tttcaataca gatttaaatg gaaagctaca agaagaaggg gttaaagaat tagttgtttg 491941 cggtatgatg tcccatatgt gtattgatgc aacagttcgt tctgcagttg aacatggtta 492001 tgtatgccaa gtggtagaag atgcttgcgc aacaacaaca ttgcaaattg aagataaaat 492061 cgttcctgct gagcatgtcc attacgcatt tatggccgca ttaaatggtg tctatgcaac 492121 agtaaaaacc acagaggcat ttttaaaata aaagaatttc ctgcgcgaac ataacgtctt 492181 tcttttcaca agaaagatga ttcaacaact taaaaaagga tgttcagaaa aatacttctg 492241 gacatccttt attcattatc ttttattgtt tttcagtatc attattccca tctgataaaa 492301 gatcaagatg tcctgttttt gatccatagt aagaccatat acagggattg tttttgccat 492361 aaatatagat attgatgaag gtttacataa agcacctaat tgcttgattt actttaatgt 492421 tagatccctc aataactcca ttctcttcta atttctctac tctagctgta gctgctgggc 492481 atgttaaatg tactctctcc cagatctttc attgaattcg gctattatac ataatttctc 492541 tataattttt tatctgtttg atctatttga acgttaattc ctttcgaaaa taaagtcaaa 492601 gagttaaaac actttttttt atctatgtat tcgaacactg ctgatattat acacttaact 492661 ctgtcgatct aagacaaata aaaaaagaaa gtgagttgta aatatgaata ttacacaaat 492721 tcgaaatgca acaattgttg taaaatacgc aaataaaaaa tttttgatag atcctatgtt 492781 agcagagaaa ggtacgtacg ctactttccc tgaaacgatc agacaagatt tatttaatcc 492841 tttggtgagt ttgccaacat caattgataa cattctggat ggcgtagatg cggtaattgt 492901 tactcatcta cacctagatc actttgatga tgtggcaaaa aacgtattgc caaaaaacat 492961 caaaatgttt gttcaaaatg aagcagatgc aaaagaagta aaagcaagtg gtttcaaaaa 493021 tgtagaagtg ctacatcaag acactgtttt tgaagggatc caattagtaa aaacaaaagg 493081 tgaacatggc agaggggaag agttattaaa cttaatgggt gatgtttgtg gattagtatt 493141 caagcaccca agtgaaaaag ttttatatgt agctggggat acagtttggt atgatgctat 493201 cgaagacgag attcatacac atcaaccaga aatcattgtg gttaatggtg gagacaatca 493261 aagattagat ttaggttcac tcatcatggg aaaagaagac atctatgaag ttcacaaggc 493321 tgctcctcat gctaagatta tatctgttca tatggaagct gttaaccatt ggacactatc 493381 tagagaagaa ttaaaaaact ttagtaaaga aaaaggattc tcaagtaata ttttagtgcc 493441 agaagatggc gagtcttaca cattttaata tgaacaccga caaataaata gaagaagctc 493501 ataattataa aaactaatca tgagcttctt ctaataatga atattttaaa ttttaaatat 493561 atcgaaaatc ctaaatatac ggaataacaa aaatggaatg ttccaatgat gacaaaaaaa 493621 cttgaaaagc aacaaagatg tgtcgttagg aggtagaatt catggtaatg acaaaaaaag 493681 atacaaatat atcaacacag cagcctcttt ggttacaagg ttatattgat tcaccagaaa 493741 aacaaaacca actttataaa aaaacattaa aaatcttgat tttttcacaa atatttgggg 493801 gagcaggact tggagctggg ataacagttg gggcgcttct tgcacaagat atgataggat 493861 cggaaaatgt agcaggaatt ccaactgccc tctttacttt tggatctgcc gtagctgccc 493921 tgcttatagg agcatcctca caacgttttg gtcgcagagc tggacttgca ggtggtttcc 493981 ttataggcgg attaggtgct ataggtgtga taatcgcggc tttaattaac agcgttgccc 494041 tattatttgt ttctcttctt atttatggag caggtatggc ttctaatctt caagttcggt 494101 atgctgggac agaccttgca aatgagaaac aacgggcaac tgctgcaagt atggccttag 494161 tttctactac tttaggagct gtagtaggtc ctaacttagt taatacaatg ggggaatttg 494221 cagattcaat tggtgttccc aatttagctg gtccgtttat tatgtcagga gcagctttta 494281 taattgctgg aattattctc ttaatttttc ttcgtccaga tccgctgttt gtatcaacag 494341 ctattgcgaa tgctgagaaa aaagacgata aagtacaaat aggaggaagt ctaaaaaatc 494401 ctgctataga caaaaaagga ataatggtag gagctgtcat tatgatttta gctcaactaa 494461 tcatgacagc tattatgaca atgacaccgg ttcacatggg tcatcacggt catggtttaa 494521 gcgaagtggg attagttata ggactccata ttgcagcgat gtatcttcct tcaccattga 494581 ctggtttatt agtagataag tttggtcgca caactatggc tattgcttca ggtgccacac 494641 ttcttgccgc tgggttggtg gcagctattg caccggcaga ctcattatca ttgctaatcc 494701 tagcactagt attactaggg gtaggttgga actttggttt actaacggga actgccctta 494761 ttatagattc aacacatcca tctctacgtg caaaaacaca gggaacattc gatgttttat 494821 tagcactatc aggagcagca ggtggagcct tgtcaggaat ggttgttgca cattctagtt 494881 atacaatact atcaatttct ggagccgttt tatcattgtt actcattcca gtagttattt 494941 ggtattttag aaggattcag gaaaaagcat aagcttatat aactgtcttt gaagaaccta 495001 agtagacatt actttaccgg aacctccttt ttctatttat tatagtaagg agttgacatg 495061 gcattagtgg catgtgtata actacacaat tatttgggat tcagagagca tgtaatgaac 495121 ggaagagata attatttatc acttttatta ttgtacggtg ttcttgtggc attaagttca 495181 gtcaattttg gtctaactgt tttctttttg ttttcatcac ctctccatat tattaacaaa 495241 cacgaaaagg attttaatga aaataaaatg attagcgtat gtatctctaa ttttcaaaat 495301 gaatgaatag tcctttttaa gatttacaca cttattctcc aaggaaaaat gactcaattt 495361 ttcgattttt tatgtaaatc aaaaaagaat catgttagag taggtgtgct gaaaataatt 495421 caaaaaatta ttttgcgata tgattaaagt aatattgcca gagagtttca attggacaaa 495481 attgtaagtg tttaatacac tggggctgca atcaaatatg cacctggaat caattgctaa 495541 acgggggagt ttatatgaac aacaagaaaa atatctttga tattgttatg tacattattt 495601 tcggtgtgtt aagtcttttt ctagttgcaa aaactgatta tggcactgga gttttagtgt 495661 ttgttgcaat tttatacctc gctgttattg cttataaaat taagcaagta tttagtaatt 495721 cagattctta aggtgtaaca caaggaggat ttcaattgag aaagaaaaga gttattactt 495781 gtgttatggc tgcatcattg actttaggct cacttttacc tgcaggttac gcttctgcaa 495841 aggaggactc taagacaacc ccttcttacg aagaactagc tctacattac aaaatgaaaa 495901 gtgaaaagat ttcatcgaac gggaaattag ttgaaattga gtatgtgagt ggaaatgaaa 495961 ctcacaaagt tcagatgaac ggaaataatc atactgtaaa agtcgatggc atagaacaaa 496021 aaggtttaaa ctttgagtat gatgaaaatg ttgctaaaag aacaaattat gaaaacaata 496081 atttgaaatc aaatgaattc acaacacagg ctgcaaaacc taaaaaggga taccattatg 496141 tggggacttt atctgggcat acaaaagcag ctaaaaatgc gttatcagtt acaatgtcat 496201 tagtcggtat tgtccctggc ttgggatggg ggagtaaggc tgccactatt ttattctctt 496261 attgggcaaa agaacaaatc cctgatgcgt attataaata tgatttatac gaaaaaggag 496321 caatgactga tagttggtat cagtatgcta cagttcaatt ttttgaagat aaagctcata 496381 aaaagaaaat gggcaaacct tggacaagta ctcctgcaaa agtagattta cctaatagct 496441 aattttaaaa tcactttgtc tttataaagg acaaagtgat tttttgttat acagaagtaa 496501 aatccctcgt ctgaggaatc ttggaaaaaa cttggttcaa ttttgatata acatgttttt 496561 ttcttgctaa tttagttttt ctatgtatcg ctacacattc taaataataa gatattagcc 496621 ggacggttga tgccaagctc aaaagtttat atggaagtca aagcataaaa aagggtgtta 496681 caacgtgtag tcttcttttt attttgccaa cgtaacaagt gtgaaagtaa tgatttgtag 496741 gatcagttaa gaaaggttta agattagata ttgaaaaatt ttatatattt tcaataaaat 496801 actggtacta taataaatgt atacagattg tatggagatg taattaatta aaaaggagtt 496861 ttttaattgc gttggagtaa atggttcaat gttttttgta tagtagcatt gggatcaata 496921 tatggttata aattatttac taaccaagaa gtcagtacta ctcgtttaat aatagcttct 496981 gtaattgtgt tgtggaatat tgttggactt tttagcaaag aatcagtaaa acaagcacag 497041 caagcaaatt aaaagtcata aagttgggaa agaaggatgt tacttatgta gtatccttct 497101 ttattattcc ttgaaaaatg aaacaaattg gagattacag cttatataat caattgaagt 497161 cgttgattat tttcatgaac aggagattta atgctttctg atgaaatatt atcgtatgaa 497221 tgttgcaaga ggaaacgtta ctcaaagatt acagggatgt gatgaacact cctctttatc 497281 gcactcacct gaccccaaat tgttggggaa gggcaggtac ggaagataga gtattttttc 497341 ttcgtaacaa atcgaaaagg ttggataata aaaaacttat aatctaaggc ggtatatagt 497401 tgtgaaaaag gcgttatttc ttatattaga ccagtatgca gattgggaag gtgtttactt 497461 agcatctgca ttaaatcaaa gagaagattg gtcggttcac actgtttctt tagaccctat 497521 tgtaagctca ataggtggtt ttaaaacatc tgtcgattac ataatagggt tagaacctgc 497581 aaattttaat ttgctagtta tgattggcgg ggattcctgg agtaatgaca ataaaaaact 497641 attacatttt gtaaaaactg catttcaaaa aaacattcca atagcagcga tatgcggtgc 497701 agtggatttt ttggcgaaga atggtttgct gaataatcat agccatacag gtaattttgt 497761 ttacttatgg aaagattaca aacaatataa accgattagc agttttgtag agaaacaagc 497821 agtaagagat aaaaatttgg ttactgctaa tggaactgcc cctattgaat ttactaattt 497881 aattttagag atgattgatt ttgatactcc tgagaacata gagaaaatga tgtatatgaa 497941 tcgttatggt ttttatcatt tttgtgataa atatggaaat ccatttgttg attaatttgc 498001 tggaaatgat tttcccgaat agggggcttt gcgattgagt tgaatttcct aataaagcaa 498061 agaaagatga tttgaggtca agtttaacaa ataatgccat caatattaat ttgcagttat 498121 ttccgattcc tgatataata aagaagaatt atttttgttc ggtgtaaagg atagtatgaa 498181 gattgacttt tcgtcttgat gatactttgg gcaaggatag tatatactgt gtggttacac 498241 actaggaggc aacaaaaatg gaacaaggta cagttaaatg gtttaatgca gaaaaaggtt 498301 ttggctttat cgaacgcgaa aatggagacg atgtattcgt acacttttct gcaatccaaa 498361 gtgacggatt caaatcttta gacgaaggtc aaaaagtatc gtttgacgtt gagcaaggtg 498421 ctcgtggagc tcaagctgct aacgttcaaa aagcttaatc ttcaatcgtt tatacaaaca 498481 ggctctttat atagggcctg tttttttatg tctatatcat actcaataaa aaaccctact 498541 caacgttcga gtagggagat gctacaaggt aatagaaaaa gatttaaaac ttcaaaggtt 498601 tgtttacagt ataacatact ggattgacaa tatgcggaat gtatataaat tatttaatgt 498661 tttgttcaaa tatagataac tgactctttt tttcactaac ctgttcgttc atttaagtaa 498721 gattagatga attataaaaa tggtttcatc taaatgttat caactcgcat atctctttta 498781 tgagaagaag ataaacaatt attattcaat gttgcagtgg atataagaaa ttcttaaaaa 498841 taatgaggag atcgattgtt tttttctcct ggaaataatc acttagagat acctaaaaca 498901 atgaaagccc tacctctctt ccatccttac ggctccttgt ccgtgccagt gtgaatcagg 498961 atactaaaaa aagtgactat tttattgagt tttttggtaa aacttcaatc ttcgcagaag 499021 aaatgtaaat aataaaaatg gattagaatg taggaataac aaaagaggtc gttaatgttc 499081 taaacataag ttggagaaga tttgcttttc atcataatat tccgaaatat cttttgggat 499141 gtatctaacc aaaacttttt atttgttttt cagtgattcc tttaattact tccagttcac 499201 taatcaaaaa ttcatatgca ttatccagca tttttttttc gcttgcatta agtgcttttt 499261 ctttcttcat acgcattaaa tcacgtacaa cttcagcacc ttcttgtatt tcacctgttt 499321 ttattttgtc cgtgtttatt ttgtaccttt gcttccatgg cagtaaccta tcggattctc 499381 catgctgaaa aatgtgcata atgtgtttta atgcaagtat atcggtaact ggtcgtatat 499441 tcgaactcaa tattttactc gttggaatca taactgtcat attactgatt gacattctta 499501 tgacataata ctgttgtttt tcctctaaga attctttttc ttctatggct tcaattatac 499561 ctgctccgtg cattggataa acaatgttat cgccaatttg aaacatatca tccacctcca 499621 tatatggtat ccttcttaag attaccatat atggaggtgt aatatcaaaa ttttaataat 499681 aacatgatcg aatttttgat gtcaataact tttttgaaaa aacagatcaa gcaaaaacaa 499741 tagggaacgt gtcggatttc caatcaggaa aaggtcaatt gatccgtgtg agcagttttt 499801 cattggctca atgacattac agaaatgatt tgagtagata agaaagaacg atattcgtga 499861 aatgtcagct aaaaatattt aaagcacatg attaagttct aatttcttta ccgatttgat 499921 atggataacg gccgacttac ttaatgatgc attttcactt atcttgcaag cagaaaaagg 499981 tttgttgata aacatttagc caccaaattg gcattattat cagggaaatt gacaaccttc 500041 aaatgggtat tgaggcgaga agaaaaataa agaaaggaga gattataaat gaagaccaga 500101 acataaagaa gtaaagggga aagaacaagg ttaattgaaa agcaaactat ataaaatagt 500161 ttgctttttt ttgttatgac ttcacttctt tttctttctc tttaatgact aataaaacac 500221 cgctcagaat taaaaacgaa cctatccaaa atgtcccgcc tatttgttct ccaagcagaa 500281 tccatccgag taaggttcca accagaggct gaaaaaagaa aaagaggcct ccacttgagg 500341 catttaataa ttgtaagccg tggttccaca ataaaaatgc acaagctgtt gaaacaattc 500401 ccaaatacaa aaggccacct agaattttag ggtcaagcag tagtggcgta aaaatcgtgc 500461 taggggagta ccattaacag ggactccatt tattaataga ataaacttta tgaattcatt 500521 tttttgtatg ataatggcgt catattcatc gcttgttgaa atttacttat gaaataactg 500581 gtactgttaa atccaacttg ataagacact tctgtcacat tggattcagg gtgttgcagt 500641 aataataagc ttttttgaat tctataatcc attacataac gtaatggcgt cttattcagc 500701 attcgtttaa aataacggca gcattcagaa cggctcagtt ggccagcttt tgcaatgtcc 500761 tctaatgtga ttttttcaac ataatggaga tggatccagt ttaacatttg tttcattcga 500821 tgacttttta tcatttcaga ttgatcgtac tctaattgaa aaccattaac gaccaggttt 500881 ttccacatta acgttaattg catcgtaatg tcaatctcat agagcgatgt cttttgttga 500941 atcaattgat ttattttttt aacagcatct agaatatttt ttgcccactg ttgatttcca 501001 gccaaaaata aatagggcaa attggttgaa aacatatagg gctgaacata gcttgaatac 501061 agttcctgag ataaaacgaa atggggtgac acattcaagc aaatatacgt acaatccgag 501121 ccttcctttt cttcggccat gtgcaggtag ccgctattga taaataatcc atccccttcg 501181 tgaacctcta ttttttcttc atttatttga aagagagcta tcccttttag tatcaaaaca 501241 aattggattt catcatgcca atgaagcgga atatagccat ttatattttg attgatcgtt 501301 gtcttgtagc aggcaactgg caattctacc gttcggtgct ctgttaattc ttttaaattt 501361 tgatcgatca caaaattctt cattctgact tcacacctca atatatttat attttttcat 501421 tcaatttgag tattttttat catgttttgc atttattata acactattat tatatttatt 501481 agtgaggagt catgtatgaa tacttccaat agaagaatgg gattgttcta tgttatcaca 501541 ggggcgacat gttgggggat tggaggcaca gtagccaaaa aactttttca agaatatcaa 501601 attgatgtca attggcttgt aacgacacgc ttgcttacgg ctggaatgtt acttttaatg 501661 ctgcaactgt tcagaaagga tcgttcccag gttattgagg tgtggaaaca caaagcgtcg 501721 gctggccagc ttctaatttt tggcctattg ggaatgctag ctgtgcagta cacatatatg 501781 gcatccattc aacatgggaa tgctgccgtt gctacgttat tgcaatattt atccccagta 501841 atcgtcatta tctacacgct gttgcgaaaa caaacggttc ttaccaaaca agatatcata 501901 actgttgtac ttgctttagt gggttgcttt tttttgttaa caaatggttc aatgtctcaa 501961 ctttcagtgc cggcagctgc agtagtatgg ggagttttat caggattcgc ggcagctttt 502021 tatactttgt atgccgttgg tttattaaat aaatttgatt ctcttgtcgt tgtaggttgg 502081 gctatgatta ttggcggttt tgcattgggt tttatccatc cgccatggca actggatttt 502141 caacgattaa ctgctgaggc gtatgcatat atcttattcg tgatattatt tggaacaatg 502201 attgcgttct ggttcttcat aaaaagcttg gaaagcctct ctccaaaaga aacaagccta 502261 ctaggcagtc tagagcctct atcagctgtt gtaacaactg tcgtttggtt aaaagcgcca 502321 tttggttctt ttcaatggat tggtgctatt tgtattatag ggataacttt aatattggct 502381 ttacataaag agccttctat ggagagtgaa aaatcgatat taaagattag gaatcatgca 502441 aatcgggata tataggggct ttttttgctt acatgaccgg tccggcaatg aaaaacactg 502501 gtggagtttg agccctctcg gcagtatcaa aaataccaag ggttttgacg ccctaggtat 502561 tttttcttca agaaccttca atttttcttc tctgattgaa aaacgtatta cttttttgtg 502621 attggtatcc aaatttcact tttaaaagat ggtgatgtta catccttatg ctcgttccac 502681 aatatttctg gaccttctat ttgttcgtaa tttgacgatg gaaaccattc ggaataaatg 502741 cgtccccata cttcttgcag tgtatccgga aatggcccga ttgattcgaa tacagcccat 502801 gttgaggcag gaacttcaag ccgtgagaag ttatctggac accgtttcgt tgtggctgcg 502861 ccaatatagt gatcgagctc tccgttttcc tctgtccgac cttcagaaaa attcgtggat 502921 gcactaatga ggcctgatgg tgctacatta gatagctctt ttagtttatt tattgctttt 502981 tcatctaaac tttcccacat agatgcaatt tccggattaa ttcctttgaa aataatagga 503041 actctttttt taatgccaac gatgcgaaat gcctcttttt cttcaatacg gtagttcatt 503101 tcatttcctc ctttaattgt tagctggaag gtcattcgtg gataagcttt aagggaatgg 503161 ccattaaatc tggcttttga tgggtttatg ccatgtaaat tttggaatgc ccgtgcaaaa 503221 gaatctggtg agttataacc gtactttatt gcaatatcaa tcacttttac attgctgtct 503281 ttcagttcaa aagctgcaag agtaagacgt ctgcgacgaa tatattccga taatgaaata 503341 cctgcaagga aggaaaacat ccttttaaaa tgatattcag agcagaaagc aagctttgct 503401 gcctcttgaa aatcaatatc attagtgagg ttttcttcaa tatactttaa cgccctattc 503461 atacttttaa gcaaatccat ttatttggcc tcctttaacc aaagaataac aggagtgaaa 503521 tgtatttatc cgacattctg tgcacagttt tgcaggatga cttatatgaa ataaagtaag 503581 tgattcactt gtatttgtac aggttttatt gaagcatgct gttcataaaa aggcatcaat 503641 aaaagaaagt tataattgtc ttataaacgg cacattcata taattgagtg aaaaaggatg 503701 cgtatcatgc ctatcaattc ttttgaaaat tatccgatga gctggaagcc atcgattgat 503761 aaagctgaaa agcctattta taaagcactt gcagggcaat tggaacagga tattttaaac 503821 ggagttttat tacctggaac aaaacttcct ccacagcgag aattggccga ttatctagat 503881 ttaaatgtga gtacgatttc aaaagcattt aaagtgtgtg agttaaaagg gctgctgagt 503941 gcgactgtag ggagcggcac atttgtatcg tatgatgcgt tgtcgaatgc gtatttactt 504001 gaggatacta agccgacaca tttaattgaa atgggagcaa tacttccaga tcacgcttca 504061 tatgagccct tgttatacca actgaaaaac atggttcatg aggaggatta tgaaaaatgg 504121 tttagctatg gccgggcagg tgaaagcctt tggcaaaaag atgcagctgt aaagctcatc 504181 caaagaggcg gatttgaaac atccgttgat cacattttat ttgcaaatgg agggcaaaat 504241 gcgattgcag cgacattggc gagtctttgt aagcctggag atcgcatcgg agttgaccat 504301 catacgtacc ctggattaaa aactgttgca tcattgctta gtgtgcaaat cgtaccgata 504361 aaatcagaaa acgatgaaat gagtccggag tcacttgaat atgcgtgtaa aaacgaaaat 504421 attaaaggtt tgtatttaat cccggattat cataatccga cgacttcctt tatgtctgtt 504481 gagaatcgaa gaatggttgc agacattgta aagaaatata atctgtttgt tattgaggat 504541 gcatcgtacc atcttctcaa caaaaatccg cttccggcac tcgcctcatt cgcaccgcaa 504601 caggttattc atattgcaag tttatcaaaa tcgttagcgc caggcctgcg tttggcttat 504661 gtagcagtgc cgagacaata taaggagcca atatcaaagg cgctttataa tttaaatata 504721 actgtttccc cgctattagc tgaacttact gctcgcacga ttgtatcaaa tcaatttgaa 504781 gtcttaattg agagtcatcg tgaacaaacc attcgcagaa atcaactcgt aaaccgatat 504841 gttgcgggat atacatgttt aggtgttgaa acaggcattt ttcgttggtt gttgttaccg 504901 ggtaaaatgt ctggtgccga atttgaagaa ttggctgctc gacttggcgt gcaagtgtat 504961 gcggctgaac gctttgtagt gggaaatagt tgtcctgaaa gggctgtaag ggtttctgtc 505021 tgtgcaccaa aaacacttga agagcttgaa caaggattaa tgatcctgag acgtttgcta 505081 gacgatctta cctaatattg tttgccatac aattatgaca ttgtatggct tttttgtgcg 505141 tgttatgatg atccacatct agagggaggt ttatacaaaa ttggctttta gaaaggaagg 505201 tcagatgatg ttagacaagg acagcgtaaa agcaatagat gttcaaactg cttcattaca 505261 gagctacatc agttcaccag aaaaacaaaa atcgttatac aagcgtacac tattcgttgt 505321 gagtatctca caaatttttg gcggtgcggg gctggcggca ggagtgactg tcggtgcgct 505381 tattgcacag caaatgcttg gcactgatgc gtttgctggt ttgccttctg ctttatttac 505441 tttagggtca gcaggatctg cattaattgt tggaagactt tctcaacgtt atggccgtcg 505501 aacaggtctt tcagctggct ttatgattgg cggacttgga gcaataggcg ttattatggc 505561 agcaatcata aatagtattt tcttgttatt tatttcgttg cttatttacg gtgcaggtac 505621 agccactaat ttacaggccc gttatgcagg tacagactta gcaaatcata agcagcgagc 505681 gactgctgtt agtataacca tggtttttac tacatttggc gcagtggcag gtccaagctt 505741 agtgaatgtg atgggggatt tcgctctttc tattggtgtt ccatcacttg ctggcccttt 505801 cattttagcc gcagcagcat atatgttagc aggtgtggtc cttttcatta tgcttcgtcc 505861 agatccatta gttatagcaa gaacaataga agcggcaaat gaagagcctg gtgataaagg 505921 acatttggcg gcaactgagc atacagaaaa caaaaaaggg ataatcgttg gggcaacggt 505981 tatggttctt acccaaatag taatggtagc tattatgaca atgacaccgg ttcatatgag 506041 acatcatggg catgacttgg gtgcagtcgg tcttgttatt ggttttcata taggtgctat 506101 gtatctccct tcacttgtta caggtgttct tgtagatagg ttgggacgta ccgcaatggc 506161 tatttcctct ggaacaacgt tgcttttggc aggtgtaata gcagcatttg ctccgggaga 506221 atctatgatt cttctcgtca ttgctctttc tttactggga ttagggtgga attttggttt 506281 gataagcggg actgccctta ttgtagattc aactgatact gccacacgag ctaaaacgca 506341 ggggacagtg gatgttctga ttgcgttgtc aggagctgct ggcggagcat tatctggaat 506401 gattgtggca ggttcaagtt acctcgcatt atcacttatt ggagggattt tgtccttatt 506461 actcattccg gtggtggtat ggtctagggg ccgctaaagg gtaggattgt ttaatttaca 506521 ttaatttgtt atattgttag ataaagtata ttgcagcatc taatattcta acgaactata 506581 gttgctccat taaatctatt ataaagattt gaccaggatt ccttatagct gtgtcactca 506641 ctgcatattc tttaattgaa tcacataaaa tggttatcgg atttgaaaaa ggcaggatta 506701 ctcgctttag gtaaaggagt cataacgttg ttaaaaaggt tttctcttgt tattgttaca 506761 ctaatgatgt ctatcgttgt tgttttagcg gctgctaaag agtcgcctgg agatcatgtc 506821 atctcatttg atgaacctat tatcttgatg atctcaattg gaatcgttgt atttttattg 506881 atccctccat tagtcatgtc cttttttggc aatttggttg taagaataat atctggtgta 506941 taccaatgtt ttatcgtttt cacttttctg gggctcattc caattggatt tcttattccc 507001 aatggctttt tgacaattct agtttctatt gcaggaactt tagtcagtat agctagtgtt 507061 gccgtaacct tatgcattgg caagaataaa aaagatatat aatcatcgaa ttgttatttt 507121 ttcagattgt cagtgaaata attatacaaa aagagaaggc ttgtgggcct tctttttttg 507181 ttgttgcatc atccccactt tgagcttaat ctattgaata ataagagaag gaacctatag 507241 aagaataaaa taaataccga gatgtcaaaa ataaaactgg acttcattat tgtgaattca 507301 cgtaaatgta aaaagattgg aaagagggga attccttcat gacaaatagc agaacaaatc 507361 cgaaggttga tgaattttta agtaaagcga aaaagtggaa ggaagaattt gagaagttga 507421 gaaccatcat tcttgactgt gagctgactg aagattttaa gtggatgcat ccttgttaca 507481 catatcataa taaaaatatt gttttaatac atgggtttaa agaatattgc gcgcttctgt 507541 tccacaaagg cgtcttatta caggatacag atggaattct cattcaacaa acggagaatg 507601 tacaggcggc gcgccagatt cggtttacaa atgttcagga aataaatgag ctagaaaaca 507661 ttttgaaagc ctatattcac gaagccattg aagttgaaaa agccggtttg aaagtggatg 507721 ttaacaaaaa tattgaattg aacattcctg aagaacttca aaataaattc gatgaaatcc 507781 ctgcattgaa aattgctttt gaagctttga ccccgggacg gcaaagagcg tacactcttt 507841 atttttctca agccaaacaa tccaaaaccc gagaatcgag agtcgaaaaa tatgtgcaaa 507901 aaattctcga tggaaaggga ttaaaggatt aggcacgcca aggttcaggc taaaggaata 507961 gcatcatagc gtaataagat catttctata gaagaaaaac aagcatagta agatgcttgt 508021 tttttcttag gacaacattc acttactgct gaaatgcttc taacattgta tgccactaga 508081 cagcgttata aaatattaat gcaacaccta gaaatctatc caatgaaata gctcaatggt 508141 atggctcatt acatttagaa tgcctaggag aactaataga accggaagat ttttagcaag 508201 ttactacact ccaaactttg tttttgtatt aatatacctt attaaccatt gtttttagtc 508261 aggtgcagac aaacgaatac tgattaatga atcatcatga tatcaatgag ccgcttgatt 508321 ttttcatcgt cgcctgtatc aacgtacact gtttttctgt tttttatgat actctcagtc 508381 acttcccgca tgacgccttt ttctatatca tcagcggaat cccagcgtaa aggcacatta 508441 tatacatgaa ttgtgccatc cccattgcca tgataagtga ctgatccatc cactaaacga 508501 gaacctgcca actgggtcac attttctgga tagctggcac ttgtatcatc attaggatta 508561 attggctcgc cagccgcaat atgtcgaaca tttaattcat ctatctcttg attaggtcca 508621 agttgaagcc aaactctggc atattcaatt ttttccgaag agtatgctgc caatacattg 508681 tcttctttgc ttttctcttc tgctgaagag gtatcatttg cagcttttgt tgcggattct 508741 tctgattctg ttattggctc cgcttcatcc ttgcgtattt tggtgctctc ttcaggctca 508801 gtgtgttttt cgtcagtttg cacagcagaa gcttgatttg aaggttgttg tgcttctcca 508861 tccttactgt ccgtacatcc agcaagcaaa atcataagca gcagggcagt attgcaataa 508921 catatctttc tgcgtttctt cattttttca ttcctctcta ttaattcagg tcagcttcat 508981 atataagttt atgtatctaa atattaccat ggaatagata ggatgatatt gaaaactgtt 509041 taagaagagg aaacgatctt gaatagcatc gcgaaaacct aagaatctta agaagttttg 509101 cccctttttc ttcaggtatt gaatgtaaag tgggatataa atgcaaacaa aaacgaaatg 509161 ccttatccac ctcgtgtcat ggcagaaaaa gtgggggatt tattagagcg gatttgataa 509221 tggcggcagg taaatgggtg ttgacttata tgtctaagcg ggagactcaa gtctgctcga 509281 tcgcatacaa aataccaagg gccagcaacc cttggtattt ttataccttc atgcattttt 509341 gaagtttatg cttaaaggtc tgccttactt tgcaaatcgc cgagctgctg caacgcacat 509401 gataacggcg atattcactg ctacgagtgc ccagcccact ttctcgtgca gaatcactga 509461 ggcaagcagc agtccaaaaa aaggctggag aagctggagc tgcccaaccg ctgcaattcc 509521 cccttgggca agacctcgat accagaacac gaagccaatc agcatgctga ataaggatac 509581 atatgcaaga ctgagcagtg cgggaacgcc gatcgccgac catgagtccg gcgtaaaaaa 509641 gaacgacaat ggcagcataa gaggaagcga cagaacgagt gcccatgaga tcacctgcca 509701 attccccaga cgccgtgaaa gtttggcccc ttctgcataa ccaagaccgc atacgacaat 509761 agaagccagc atgtacgcgt cgccaagcgg ggatgaacct cccccctgaa tgagggcgaa 509821 acctgctact aacaagctgc cggcagctga gaaaatccag aagacggggc gagggcgttc 509881 acccccgcgc agtacgccga agactgccgt tgcgagtgga agaagtccaa tgaagacaat 509941 ggcgtgtgcg gatgtgacat gctgaagcgc taaagctgtc agcaacggga aaccaatcac 510001 tacgccgaac gctaccacta acaatgaaat gagatctctt ttggcaggat gctgctgccg 510061 gaagatgaga aggagacctc ccgccagtac accagctatc gcagcacggc aaactgtgag 510121 aaataacgga tcgaagtctg acacagccaa acgggtcgca ggcagcgagc cgctgaaaat 510181 gagtacgcct ataaaaccat ttatccagcc atttgttgtt ttgttcatta taatcactcc 510241 acatatcttt cttgttcatt gtctgtattt tcttaacaaa accagcagct aaggattaca 510301 atgactataa actggaattg gccttttata aacagccagt tttcataaaa aaatgcatac 510361 cagttaggag aacaacgcgc aaatggatat cacgcctttt ttgaatagaa ctctggatat 510421 tccgctttat cagcagcttt atcggtattt taaagaaaat atgcatcggg gccgtattca 510481 aaaaggaatg aagcttcctt caaaaagact cctggcgaat cagctttcca tcagccaaac 510541 gactgtagaa cgtgcctatg aacagctcgc tgctgaaggt tatattgtga gcaagccaag 510601 aagcgggtgg tttgctgatt atcatgattc tgattttgct tatgatagaa tgccaagcac 510661 aacacccatt caacaagaag cagaagaaaa taaacaatgg attgattttc attatgggaa 510721 tgtagattct tcttacttcc ctttttccgc atggcgaaaa agcatggtca atagcttaga 510781 ccaatatgga cacgagcttt atcggccggg acatgtttta ggagagtttg agctgagaac 510841 actcattgca gagtacctgt atcaatctcg gggggttcat tgcggccctg aacaagtgat 510901 tataggtgcc gggaacccta ttctgctgca aatcttgtgc caagtttttg agccgaatat 510961 ttctataggg tatgaggatc ctggttatcc aagagcacgc aagatttttg aagccaaccg 511021 catgaatatt gttcctatac cagtcgatga tgagggaatc tgtatacaga agatcaaaga 511081 acagcagcca aaccttgtat atgtcacacc ttcccatcaa tttacgctgg gaaccataat 511141 gacaataaac agaagaattc agctgctcaa atgggcggcc gaaaatcaat cctttatcat 511201 agaggatgat tatgacgggg aatttaggta cacaggacag ccggttcctt ctctgcaagg 511261 gcttgatcag cataaccgtg tcatttatat gggcactttt tctaagtctc ttttgccctc 511321 gctgcgtatc agctatatga ttcttccttc gcctctttta aaaaagggtc atgaaatcac 511381 gtccttatat aagcagacag tgtcctgcca cagtcagcta accctagctg aatttataaa 511441 aaatggagag tggcaaaaac acatcaacag aatgagaaaa ctttaccgca aaaaaagagc 511501 cattgtatta gaggcagtgc aaagggaatt aggagagcat gtcagaatcc gcggagaaaa 511561 ctctgggctt cgtatcttac ttgacgttta tttgccattt ggtgaaaaag agttaattga 511621 gaaggcgaaa aaacatggag taaaaattta tcctgtttct ctttcttatc aacatcatcc 511681 tcctacaaaa acggtctcgc tcgggtttgc aggggtttct gaatccgaca taagagaagg 511741 cataaaaaaa ctgaaggctg cctggaagat atgagggagc tttcagttta gcaaaacggc 511801 caagtgacga ctaagtgttg agagctgttc aatatttttt aagtatatga tgagtgcctg 511861 cagtccaggc cacgatacgt ctgtttagcg aaaaacagaa ttttttattt gctcctcaca 511921 gtgctaaaat aaacaaaata gacaattgaa aaaatagagg tgtaagaatg aagttagatg 511981 agtttacaat tggccaggtc ttcaaaacga aatcattaaa agtatcaaaa gatgatatta 512041 tgcggtttgc gggtgaattt gaccctcagt atatgcatgt agatgaagaa aaagcgagta 512101 aaggcagatt taatggaatt atcgcttccg gcatacaaac actggccata tcttttaaac 512161 tttggattga agaaggtttc tatggagacg atattatagc cggaacagag atgaatcata 512221 tgacattcat aaaacccgta tatccggatg atgaattgtt tacaattgtt gaggttcttg 512281 ataagcagcc aaagagaaat gaattgggaa tactcacagt attgctatct acttataatc 512341 aaaaagaagt aaaagtgttt gaaggtgagt tatctgtatt gatcaaacga taactcagaa 512401 agcccgcttt tcgcgggctc gattgaagca gatgggtgaa agatgttagc gggtttcctt 512461 tgaaaaataa gaggttaaaa catcataaac aataggcaaa gaagtaaatc cctcatcttc 512521 tagaaaatga cctccgtgct gaacttcata taacgcagca tcaatttgtt gtgccagatc 512581 cttgctgaat gaaaaaggca caatttggtc gtccttagaa gcaatgacag cacggtgctt 512641 cgcggactcg atgatttttt gatgatcaaa cgatccctgt gtaaattcat ctaacatctg 512701 taaagtgggc aatgatttgg caaagccgga aacaagtatg attccgccaa gctgttttcg 512761 taattgaaga tgttccaaaa atctcaaaat ggcggggcaa cctaagctgt gcgcaaccaa 512821 atacgtattt tcatgtaaag tgtgctgata taaagagagt gtatccagcc aatcctcaag 512881 tcttggctgg agcggattag gcatgtttaa aatgtctgct tggaccccat ctgcgagcag 512941 acgttttttc agccaaggga accaatgatt tgttgaggag gctctgtagc catgaatgat 513001 atagacttgt tttgtcatta tttcctccta agaaatattt tcattcagta taaaattcct 513061 ctcattggga aacaagtacg cacttttttg taagtagctt tacatatgag gccctccttg 513121 tgccattccc cacttacaca tctcatctat gaggggatac aaagatcgcc ctctgtcaga 513181 taacgaatac tctactttca gtggggtgtg agaaacctca gaccgatgaa taaggccgtc 513241 agtttgcaat tccttaagct gtgcgcttaa cattttatgg gtgatgaagg gcatagccct 513301 tttcagctcg ccgtatctca tcgttttttc acaccctaac tcatagagaa ttctcatttt 513361 ccatttgccc cctataagag ataaggtgta ttcaaatggg gcttgtttac tgcggcacag 513421 gctattcatt gtaatcaaac ctcctttttt aagtatcata tcagaataaa ttaggatttt 513481 cggtgttgaa gtttgagggc gattcacgat ctgaagtgaa aggggccgct tgctcaacag 513541 gcggcacggt acatgaatgt tctaagtcaa agagggttac cttactgtta gttactttat 513601 ttaaaaaaac gcatgttttt agctgaaaat atctattatg gtatatttaa atataaagaa 513661 atatttgaga aatgaggaat ggtatgaata cacccaaaaa acataagaaa tttaaagcga 513721 aaatgattct ccaaatcatc atggttatca ttggaggaat catagcggca tatggactag 513781 aaacagtgct cattccaaac agtgtatctg atggaggggt gacgggtctt agcatcgttg 513841 gttcacagct attcaacttg ccgctgggga ttttgattgc tgtgatcaac attccatttg 513901 tctggttagg atataagcaa attgggaaaa gctttgcatt attatcaatt atcggaatcg 513961 tatcgcttgc cgcggggaca agctttttcc accacacacc cgctatcata gaaggagata 514021 ccctgttaat taccgttgtc ggcgggatta tccttggatt cggaatgggg ctggcgctgc 514081 gtaatggcgg cgcattagat ggaattgaca tgcttgctgt gctgctatcc cgaaaactgc 514141 cattcggaac gagcgatctc attctattct taaacctatt tgtgtttatt tttgtttcca 514201 cagtatttgg cttacaaggg gcattgcttt cagtcattgc ttactacatt gcatccaaag 514261 tgattcatgt tgtggaggaa ggcttaagcg gctctaaaac ctttcaaatt attacaaccc 514321 aacctgaatt aatggtagag acaatacgtg atcaattagg ccgaagcgcc acatataaag 514381 aagcttacgg gggtttttcc cacgagaaat ttaaagaaat cacatgtgtc atcaaccgtt 514441 tagaagaaac caaactaaag gaaattatta atgatattga taaaactgcc tttgttaccg 514501 tgtatgatgt agctgaagtg aagggcagca attttagaaa tcttaatcat cactaaaaaa 514561 tagaatgacc tttttaaccg taactgacat gccgcgggta atttaatcaa aaacactttt 514621 ttgaggcttg tgggtgaata accggtgaag gtctgaatca cagaaatacc aagggcgtca 514681 aaacccttgg tattttttct ggttattaga ttttatcttc agctttacgt gctgcttcga 514741 gcttatcaat cctgtcttta tatttttctc cccagtcctt catgtgcagg ataacaggtt 514801 ctaatgttct tccaaactca gttaaagagt attcgacttt tggagggacc tgtttataaa 514861 cctcgcggtg aatcacgcca tcccgttcca attctcttaa ttgtagcgtg agcatacgct 514921 gggtaatttt tgggtatagt tttcgaaact cattaaacct ctttttaccg tcaatgagat 514981 gataaagaag aatgcctttc cacttacctc cgatgatatc taatgttgtc tccaccggac 515041 atccttcaaa gtcatcagaa gaataatcaa tgccgagttt acgatttctc aagctgttca 515101 ctcctaatag tatacttttt gatactatat acattcaatg tgcgtacttt ttatatttta 515161 atatacatca tataatgatg tcacatctaa ggaatgaaag gaatggatca tatgaaaaca 515221 ctcgtactcg ttgtacatcc gaatatagaa tcctctcgta tcaataaaaa gtggaaagaa 515281 gccgttttaa gtgaaccaga tgtaactgtc catgatcttt atgaaaaata tcgcgatcaa 515341 ccaattgatg tggaatttga acaacagcag ctcctggccc atgaccgtat cgtttttcag 515401 tttccattat actggtacag cagcccaccg cttttaaaac agtggtttga tgaagtgttt 515461 acgtttggct gggctcatgg tcccggcgga aataaattga aggggaaaga gtgggtaact 515521 gccatgtcca tcggttcacc tgaacactct tatcaagccg gcggatataa cttgttttcg 515581 ataagcgagc tgacaaaacc gttccaagca tctgcccatt tagtaggcat gacctatctg 515641 ccttcctttg ccgaatatcg cgccaataca atcagtgacc aagaaattgc cgaaagtgcg 515701 aatcggtatg taaagcatat tacaaatata gaattaaacc cgaaggttcg cctgcaaagg 515761 tatttgaaac agctggagag tgtcgattta acataaagat tgatttttga aaatcctgta 515821 ctcaccaagc aggatttttt cttgttcagc agagggattt taacatatag caaaaaaaga 515881 agaagccacc aaaaataagc tatttgcttg gtcctgactg cttatttttg gtgaaatact 515941 tatttctctg tgatgaaata aagcaaagcg atgaccggaa aagcgattcc aatccataat 516001 gctgtactcc atccgcctga ggcatatgcc catcctccaa ttgatgaccc tatcgcaccg 516061 cctagaaaga agatcgccat gaataatccg tttaatcgac tgcgaatttc aggcgccaac 516121 gaaaaaatag cacgttgact gagcacaagg tttgcagata cacccatatc taacagaata 516181 gcagcggcca ctagaactgt tataccgacg ggggagctgc tctgaatcat gagcggcagt 516241 aataaagaga caacgacaac accgagagcg attccagtgg caagcctggt taagcctcga 516301 tcagccaggc ggccgcctat tggtgcagtg actgcacccg caatgcccac caatgcgtag 516361 agtgctattg ccttctgaga aaaatgaaaa tcaggaccgg acaataataa aggaacagtt 516421 gtccagaaca agctgaaagc tccaaataca aacgcatgat agatggcacg gcggcgtaag 516481 actggagtcg tgcgcagcag cttccacatt gaaccgagta aggcagtata gtttgtattt 516541 gctgttggtt ttctggcagg aagcactttt gataatacga tggccaggat aacacttacc 516601 acggcggaca aagcgaatat tgcattccac ccccagatat cagcgactag actagatatc 516661 ggacgggaaa gcataatacc gagtaataag ccgctcatga cattgccaac aacccggccg 516721 cgtgcagcgt ctgatgcaag gtatgatgca aatggaacaa gcacttgggc tgcgattgat 516781 cccaatccga cgaaaaacgc agctgctaaa aacagtgttc catgcttcac aaatgctgtt 516841 agtgtcaaag ccgctgcgct tagaaggagc gatacaacaa taagtttttt gttttcgata 516901 atatctccta aagggacaag gaatagtaag ccggcaacgt atccgatttg ggtgagtgtg 516961 acaatcaatc cagcaccgct tggagaaagt ccaattgcct tactaattaa tccgaccaag 517021 ggttgtgcat agtaaagatt agcaacaatg ataccgcatg cagttgcgag aagaagggtt 517081 aaactgggtg aaatcctctg acctgcttgt ttgtttccat tagccatatg aatgaactcc 517141 tttttaagtg gttttttgag tgtaatcatg acttctcaca agtgatttta taaactgaac 517201 gttcagtttc gtcgattaat aaaaataata tactaaacgt tcagttttgt aaatggattt 517261 ctgttttctt tttttattca atttaagtat actgaacgta tagtttatat tgcgggaagg 517321 aatgatttat gtgcagagta aacgagggcg gccgcgtgat gaaggaacgc ataaggcgat 517381 tctctctgca gcctatgacc tattgctgga aaaaggcttc gatgcggtga cagtcgataa 517441 aattgccgag cgtgcgaaag tgagtaaagc aacgatttat aaatggtggt ctaacaaggc 517501 tgccgttatc atggacagct ttctttcgac cgcgacggac aggctgcctg tgcctgatac 517561 agggtcgtca gtacaagata tagtaaccca cgccacgaat ttagctaggt ttttgacaag 517621 ccgggaagga accgttatta aggaattaat aggtgcaggg cagttggatg aaaaattggc 517681 agaagaatat cgcacgcgat ttttccagcc tcgccgcctc caagcgaaag gccttctaga 517741 aaagggaatt cagaaaggtg aattgagaga gaatcttgat attgaagtaa gcatagatct 517801 catttacgga ccaattttct atcgtctgct tataacaggg gatgaggtga atgattccta 517861 tgtgcgtgat ttggtgatga atgcgtttaa gggagttcaa gctacctctg ctacagagag 517921 tatgtagctg ataagaactg caaaagctgc ggattatatg acaaattggt tccatcgtac 517981 agtgaaatat aagatttttg ttgctgagcg gaatcatcga gggaaaagtt ctcttatcgg 518041 atgtcgaaaa agaagtcatt caatcgtgaa tacataacat catattatta cattcctttt 518101 catcgattgg aacaagggtt ctatacttca atggaatacc gcaaagttgg agtatttaaa 518161 caacagggga aaatcgatgg ccattatgta ggtgtcatgg caatggaaaa aatacttgca 518221 atgtaaacag gcctctaaag agacctgttt tttaatatcc agatgattgt ctagtttcag 518281 cttgggctct atgaccactc ccataactga aatagtctaa tatttatacc agaagggatt 518341 gtttatataa ataaaagttt atataatgac gggggcgcta aggaaacgcg gggagcgact 518401 caggttttcg tttcaaagtt ttgatcctta agatatacgg agcgctacat atggaaacgt 518461 aaaggggaat gtataatcat ttggcgtgta tataacgatt tgcttatata ttgatttggg 518521 aaggaggagc tcatatgacg attgatgttg cggcgatgac tcgttgtttg aaaacactta 518581 gtgatcaaac taggcttatc atgatgagat tatttcttga acaagaatat tgtgtctgtc 518641 aattggttga tatgttcgaa atgagccagc ccgccataag ccagcatttg cggaaattaa 518701 aaaacgcagg ttttgtgaat gaggacagaa gaggccaatg gcgttattat tcaataaatg 518761 gttcctgtcc tgagtttgat acattgcaat tgatcttaca tcaaattgat caagaggatg 518821 aattgttaaa ccatatcaaa caaaagaaaa ctcaagcgtg ttgccagtaa ggaggcatta 518881 gattgacatc aatgattttg gcagtattca tctttttatt aactctagta ttggtcatat 518941 ggcagccgaa aaatttatct atagggtggt cagcctgtgg aggcgcagtt ttagctctaa 519001 tagcaggtgt tgtcaatttt catgatgtgt taactgtgac agggattgtt tggaatgcga 519061 ccttggcttt tgtggccatc atactgatat cgttaattct tgataatatc ggtttctttg 519121 aatgggcagc gcttcatatg gctaaggctg caaaaggata cggtgtgcgg atgttcgttt 519181 atgtatctct attaggagct atcgtcgccg cgttatttgc aaatgacggt gcagctctta 519241 tattgacacc aatcgtatta gcgatggtca gagcattaca ttttaatgaa aaattagttt 519301 ttccttttat cattgccagc ggatttattg cggataccac ttcgcttcct tttgtagtaa 519361 gcaatttggt caacattgtt tcagcggact attttcatat tacgtttatt gattatgcat 519421 ccagaatggt tgtcccgtac ctgttttcgc tgctggcgag catcattgta ctttaccttt 519481 tctttagaaa aagcatacca aaacgctatg atctgactga ggttaaaaaa cctgttgaag 519541 caattaaaga tcaaaacatg ttcagactgt catggtatat cttagggctg ctgttaattg 519601 gatattttgc aagtgaattt ttttctatcc ctgtatcagt ggtagcgggc agcattgcaa 519661 tcattttctt aatcgctgcg caaaagagtc cggccgtcca tacaaagaaa gtggtgaaag 519721 aggcgccatg ggctatcgta ttcttttcaa ttggcatgta cgttgttgtg tatggtgtcc 519781 gaaatgccgg attaacggat gtcctttcag atgtgattca agccgcagct gatcaaggat 519841 tgtttgctgg gacaattgga atgggcttta ttgcggcgat tctttcttcc attatgaata 519901 acttgccgac tgttatgatt gacgcattgg ccattgccgg tacagataca catgggatga 519961 tgagagaagc gcttatttat gcaaatgtga tcggttcaga tttagggcct aaaataacac 520021 cgattggttc cttagcgaca ttattatggc ttcatgttct ttcgcacaaa ggtatgaaga 520081 tttcctgggg cacgtatttt aaaacaggaa ttatcctcac gatacccact ttattgatca 520141 cacttgtcgg cctgtatatt tggctgctga taatccattc ttgtttctaa aaggacaagg 520201 tcactatatc aaggaaaaca atgcactggt aactcttgcc gcagccaaat ggctgaaggg 520261 tgggggagaa aataccttgg ggctaagtgg aatgtgtaca gcgcaggaat cgaagctcaa 520321 ggatgacatc gagtgctgtc aaagcaatga aagaagcagg gattgatatt tcaaatcaaa 520381 catcggagaa atttgatgat ccggcaaaag cacacggaac agaagaagtg tttccaaagg 520441 gtccgtgatg aaattggtga ccgtttaaaa cagtttgctg taactgggga ataaagaatc 520501 gatatattca gcgttttctt gggttatata atacaatgtg ttgttcaaca ggtgtctgcg 520561 agctgagtgc agacacctgt ttttgttttt atttgtctga gattcgtaac agggaagtta 520621 tttagctggt gacagaggaa aattgatttg tgaacagaat catgaaggag acggtgtttt 520681 aaaggagttg tctgttttgc aggaattaac aaaaaaaaaa tacagtagct taaaaacaat 520741 gtttgatgac aaatattgtc ccacatttgt ctattcaata ttagaccaaa ccattccggg 520801 agctgtttat gcagatgatc aaacctttcc taaatcgttt tttataggaa ctgaatcagg 520861 catttatttt attgcgggag accaagggaa tcgggatttt catgatttca ttgcaggata 520921 ttatgaagaa caagtgaaat catcaaaacg atttaccttg ttttcttcca gtgatacatg 520981 ggatagcgta ctgaaaccca tactgaaaga tgacttaaac caaatgagaa gagctgcatt 521041 ttcttatcaa ccaaaatctt tcaaaaagac tttgcaactg ccaaaggggc ttgtattgaa 521101 aagaattgac gaagacatca tttcacatag cacagcgttt aacagcgcgt attatgagga 521161 gtattggaat tctgtctcac agtttgcttc aaaaggtttt ggatttgccg tattacatgg 521221 caatcacgta gtaagtgagt gtacctctat atttttaggg cataatcgag cggaaatgga 521281 tatctataca cttgaagaat atagaggact ggggttagct tattgcgtag caaataggtt 521341 tatagcgttt tgtatggaaa atgggattgt tcctagctgg gattgtgata tttgcaacaa 521401 ttcgtccatt gcattagcag ctaaactagg gtttaagacg gtaacggaat acactattta 521461 ctactctggc taaccttaat gaaagaacct taaaaggaga taccaaccga tgttggtatc 521521 ttttttgttt tagagttttt ttaccctttt agcagaaaaa tgggtgatga aaatcttatt 521581 cattttattt acttttaggt aggtaaaaca taccccgcca actgtaacca ctccgcctag 521641 cagagagagc agtgtgggta tctcgccgat ccagagccaa gatatgatca aggctaaagc 521701 cggtgtaaca taaagtgaaa gggttgcttc tgaagcaccg acgaatgaag tgacatatgc 521761 tagtgcgaag taaggaataa ccgtcggcaa taatcctaag taaacgatag acaaagttgc 521821 gcttattgaa gcgttcatca tctcttcgcc taagcctggc agaaacacaa gcataggtat 521881 tgttccgccc caaatggtga atgtaacgaa tggaataaaa ccatattttt ttatatagcg 521941 ggcttgaaaa acgaaataaa tactctccga aaatgctgcc agcaggatga ccaagatacc 522001 gctcattgaa tatgtaaagt ctcccgcccc aaatgcaatc aataatacac ccaataaact 522061 gatcatagag ccaagccatt tcgtaaatcc aaaatgctct ttataaaaca ggcgggatag 522121 catggctgag aagatcggtg ccgtagtaac gagtaagctt gcaactccgg cactaactgt 522181 tttttcaccg atgttcagca aaatgtgata gaatgcaaat cctaaaaacc ctaaaagaaa 522241 aatggcagga atgtctttca agtcgggtag gcgcatctga gtcaaaacag caaaaagcaa 522301 taatgccata gagccgatta acaaacgaaa taaagcaagg tgttctggcg tgtacccttc 522361 aagtcctgcg cgaattcccg gaaaagcaga tgcccataaa ccaatcatga gactatgaga 522421 tatcattatt tgaactgttt tctttcgcat tcctctcact cctctttaca aaaaccaacc 522481 agttatttaa tgtgtttcta tactaataaa gatttgatga tatggcttca accagttcaa 522541 tagattttga cccaaccaat ttattttaag gagaccgatt ctatgagctt tccagaagaa 522601 aaaaagatga aaaagctccc taagtacaga caaatcgttc attttattaa agagaaaata 522661 ggaaatggag agtggccgat tggaagcaag attccaagcc agcgcacgct tgcaaaagat 522721 tttcaggtaa atcggagcac agtgattaca gcgttagagg aattgatggc cgatgggcta 522781 atagaaggca caatggggaa aggcacagtt gttatcaaca acacatggac actgatggct 522841 aagaattctg ctcccgattg ggatcaatat gtcacctctg gcattcagat gccaagccga 522901 aaaatcgttc aagagataaa tcaatcagaa tcaaatacag accttataca gctcagtaaa 522961 ggtgaacttt cagctgagat ttttcctttg gctgttatga aagagatgat ggggaaggta 523021 tctcaacaca tggaggcatt cggatatgaa gaaccaaaag gttacttacc tttgagggag 523081 gcattaagca actatttaaa aaccattgga atcaacgtct catcttcttc cattctgatt 523141 gtctcaggag cgttgcaagc cttgcagctg atatcaatgg ggctgttaca aagaggatca 523201 accgtttatc ttgatcagcc ctcctacctt tattcattac acgtatttca atcagctggt 523261 atgaagctga ctggacttcc tatggataat gaaggacttt tgcctgaaaa tgttcattta 523321 acaagaggag agcggggaag ggctatctta tatacaaatc catgttttca caatccgact 523381 ggtattctta tgtctaaaaa gcgacgggaa gaaatcctag cagtaagtga gaatacacag 523441 cttcctatta ttgaagatga catttatcgt gagttatgga tcgatgaaat tccgccatat 523501 cctattaaaa caattgataa aaatggacac gtactgtaca taggaagttt atcgaaaaca 523561 ttaagcccag gtttgaggat tggatggatc gtcggaccgg aaccggtgat tgaacgttta 523621 tctgacatta aaatgcaaac agattacgga tccagttcgc tatcccagag agtagcggca 523681 gagtggttta cttccggcca ctaccagcag catgtagaaa aggttaggca gcaattaaag 523741 gtgagaagag aattggcctt gagtgcttta gaaactcatt tgaaagaagt ggcgacatgg 523801 aatatcccaa aaggagggtt ttttgtctgg ataaaaatat tgccttccat atcaatgaaa 523861 ttactttata ctaaagcctt atcaaaaggg attctgatca atctcggcag tatctatgct 523921 caggaaaaag ggaattatat tcgcttatca tatgcttatg catctcttga agaccttcaa 523981 aaggggattt atgagttggg tttaatgatt aaagaattgg caagcaggta acttttatat 524041 ccttaaatgg atgtttcact aaaaaagaga tcaagcctaa tgatcgcttg atctgataat 524101 aacaagggtt actagaatag accaaatcat ggttcggtct taaaataatc atgtctctga 524161 acgaaaagtc tttccgactt ctcttcctaa accaaagtag tgtctgaaat tatagataag 524221 cgggctccat ttggaagggt tgatatggtt ttcgtccaga atgatacttt cctcggcatg 524281 aaaatgtagt gcctgcgtct ctacaattgc gaatgacgat tcatattctg gaagccgaat 524341 gtgtttcact tcggcttcga tttggatagg gcattcttta attcgtgttg gtgatactgt 524401 ttttgattgt aaaggcgtta accctgctgc ctcgtatttt tcttttttat atgtaaatcc 524461 gatctgcttc tttaaaggcg gtatactctt ttttccgcta taagatgaaa ttctttcaac 524521 gttttcccat aaatccgggc caggcaagtt tatgacacac tctttgtgtc tttccaaatt 524581 gtcgatggct tttcctccca gtcctactcc aaggattata taatgtccaa gagcccaaga 524641 agaagacata ggactaatat tagtggttcc atcctcattc aatgtggtta gaagaaatgt 524701 cgaggtacca taatacatga tcttgggttt gatttcctta aatcgacgag tgtcttgttt 524761 tttgatgtcc aacgtttttt cctccttgtc acgcttacat ttatattgta aaggattaac 524821 atttcaacta tcatcgaaat atgaatgtaa ggaggaaaat catgaatcct aatattgcaa 524881 aaatctcttc gttgctatca gatccctcgc gttcttccat tcttctcagt ctgatggatg 524941 gaaggataca ccctgcggga gagcttgcat atctcgctaa cattaaacct caaactgcaa 525001 gttttcacct gaataaattg cttgaagcaa agctgattag cgtagagaag catgggagac 525061 atcggtatta cagattggct gactcagatg ctgcaaatgt gatcgaacaa ttgcttcata 525121 ttgcgcctaa agcaaaagtc aaatctttaa aagagtcaaa agagaaaaag gacttgcatt 525181 tcgcccggac ctgttatgat catttggcag gttatgtggg cgtgcaaatg gcacattcac 525241 tagttgagca ggggatgtta aaaaaagttg atttaaactt tgaggtgact tcagagggtg 525301 ctttattctt ttcgaagtta ggcatcaatg aagagcaaca acggaataag aggagagcct 525361 ttgcccgctg ctgtttggat tggagtgaac ggcagcatca tattgcagga gcattaggaa 525421 acgccctatt ggtgcgcatg ttagaagaag aatggatcgt tcgtatgcct aaaacgagag 525481 cgattaggat tacacaaagc gggaaaatcg cgtttgaaaa gcacctaaac gtgaagattt 525541 aggattttga agcggaaaca tcagatgatg aggcacgata tctaggagga gtaagatttg 525601 ttctaatctt actccttctt cttattttga agcagctcga ttccccattg caatagagat 525661 gcggttccaa ctgtttattt gattaatgat cagaacaagg tcaacatatt gttcctcatc 525721 ataatgttcc cgcacccgat gatatagctc atcaggaacc cttttagatg gaatgagcgt 525781 gatgtgttca gatagttcga gagccgcttt ctcttcaggt gagtaaaaat cacattcatt 525841 ccaagcatgt aaacagtaaa ttcgctgttc agtttctccc attttgcggg catcggacgt 525901 atgcatatct atgcagaagg cacagccgtt catttgagag actctgattt tgattagttc 525961 tctcgtcgtt cggttaattg aggattgttt cgtgtatttc tccatatcca tcatgatttt 526021 cataccttca ggtgcaatct catagtagga cactctttga ctcataaagc aagactcctt 526081 tccatagaat acctagattg tatcccggta ttgatcattt taccaatgtg cggtttgaat 526141 gacagctgtt tcagcgtctt ttggaaagaa gcttctttga ataaaaataa gggtagccag 526201 caatgatgag tggagctgct aatgcaagca gtatccatga gcctgattgg ctgtctctag 526261 tgactctaat gaatatataa gtaccgatca gaaaatataa taaagcacct agaaaccaat 526321 acatgttcat tcctcttttt ccttgctttt tggttgcgca tttttgtctg tcatatggct 526381 taatcgatca gggttctgat tttttaatac cttttcggtc cggattcctt ttctctttaa 526441 tgataaaatt gtgagatcaa tcgatttcaa tgatgatcat tccttcaatg aatagtaagt 526501 tccttatgat tttaaaggta aatttgaaaa gataaaacgt acatagaggc agaacgttca 526561 tgtacgtttg ggcaatgatc acttgttgga aactctaatg tttccctgca cctgatattg 526621 ttgtgttcct tctcttccta taaaatgatt ggatacatgt atgtttgcac gttgaaatat 526681 gggttcgatt ttcatgaatc tctattcggt gaaacaggta aaggaagtgg ataaggtttg 526741 cttataagga atccttttaa agataaatat tactcacatg ataggcgggc attaaacatg 526801 cttgcactca gagtgccggg cctggctttt attctcatga tctatatagc ctctatcgtg 526861 ctgcaatttg tttctggggg ctggtccatt ttattgcttt atgcgtttac catattaatc 526921 gccatttttg ctttgcttca ttggcactca tatcgctggg ttaagaaaag agtgattctg 526981 tatttcgcgg tacaaggttt gatcaccttt gcacttgcta atctcatgac tggcttcttt 527041 atacttgtga ttatcggcct ttatgcattt ttaattggac aaattatagg aatggcagac 527101 agaagaagga cttttctcat tctttatcta ttgctgctgc tggtcataaa ttcggcgtat 527161 caccttcata aaggtgaagt tttgcatttt attgttattg ctgcgccgat catgattgtc 527221 atcatcactt atgccgcaac attttttgcc caagtcgatg aaaaaataaa agctcaattg 527281 actcttgaaa ggctggagct ggctcatcag caggtagaac agctgacgct gcagaacgaa 527341 agacagcgga tggcccgaga cttacacgat acgcttgctc aaggtcttgt cagtttaaat 527401 atgcagctgg atgcgattca tgttcatctc gccaaaggca acacagagag agcgaaggaa 527461 atcatacaac aatcgatgaa aagagtgaaa agcacaatag ctgatgcacg ttcagctatt 527521 gacgatctcc gcagcaaatc agaagaaatc ggtgttttaa aagaaagaat tacctcgcta 527581 atggatcatt ttatagagtc gacaggcatg gcttgtttat tagattacag attgcatcag 527641 gtgctggatg tgcgtacagc tgaaaactgt tattacatca ttggagaatg catgacgaat 527701 gcggcaaagc atgctgaggc gaaaacaatc tggatatcca tttgggatga tgaaaaggga 527761 aggctccatt taacagttaa ggataacggc aagggatttg atgttgaaaa aggaaagaaa 527821 aagagaggac attatgggct tcttggcata caagaacgcg tcagggcaat aaatggccaa 527881 ttcaatatca agagtacaaa attgaaagga acacaaattg agatcactgt accaattcag 527941 ggagagatgc aagatgaata aggttttaat cgttgatgac catcttgtcg tgagggaagg 528001 tctgaagctt ttaattgaaa cgaatgatca atacaccatt ataggagagg cggaaaatgg 528061 aaaagtagca gtccgtcttg cagatgaatt agaaccggat atcattctga tggatttgta 528121 tatgccggag atgagcgggt tagaggccat taaacaaata aaagaaaaac acgatacccc 528181 catcattatt ttgactacat ataatgaaga tcacttaatg atcgaaggga ttgaattagg 528241 agcgaaagga tatctgttaa aagatacgag ttcagaaacc ctttttcaca caatggatgc 528301 agccatcaga ggaaatgtgc tattgcagcc tgatatcctt aaacgtctgc aagaaatcca 528361 atttgagcgg atgaaaaagc agcgcaatga gacgcagctg acagaaaagg aagtcattgt 528421 tctaaaagca attgctaaag gtcttaaaag caaagcgatt gcctttgatt tgggcgtctc 528481 tgagcgaaca gtaaagtcca gattaacgtc catttacaat aaattaggcg cgaattcaag 528541 aactgaggca gtaacgattg ccatgcaaaa aggtattctg acaatagaca actaaactgc 528601 atatttgaaa attgcccaaa cgtacatgcc cgaatgtacg tttttttcat ttcattgtca 528661 actacaatga gaaagaatgt gatcaagcaa tgtgttgaaa ggagattatc atgtcaaaaa 528721 tgttatatac attaggagga tgggttgctc gcaatcgcat aaaagcaata tgtgcgtgga 528781 tcgttgtgtt agttgctgcg ataggccttg cagtgacctt gaaaccaagt ttttctgagg 528841 atatgtccat acctgacaca ccttcggaaa aagcgatgga tgtgattcaa aaagaatttc 528901 ctcatggtcc tgataaaggg agcatacggg ttattttcgg tgctggtgat ggggagaaac 528961 ttactgggaa gccagcaaaa aaagcaatag aagatacgtt caaagaaatc agtaaagatg 529021 attctgttga ctcgattgca agtccttttg tgacagggac aatcgcgaaa gatggcacag 529081 ttgcctatgc tgatatccag tataaatcat cagcagatga tataaaggat tactctatca 529141 aacacttaaa agacagtttg aaaatggctg atgatgaagg attgcaaact gagctaagcg 529201 gagatgtacc gggagcggag atggagatag gcggtgtctc tgaaattgtc ggcattatct 529261 tggcttttgt cgttttagcc attacattcg gttctttatt aatagcaggt ttgccgattt 529321 taactgcact gattggttta ggtgtaagta ttggactggt tttgattggg acacaagtat 529381 ttgatattgc ttctgtcagt ctttcattag ccggaatgat tggccttgct gttggtattg 529441 attatgcttt atttattttt acgaaacacc gccagttttt aggcgaaggc atacaaaaga 529501 atgaatcaat tgcgagagcc gtgggaacag cgggaagtgc agtggttttt gccggactta 529561 ctgttatcgt tgcactttgc ggattaactg tcgttaacat tccttttatg tctgcgatgg 529621 ggctgacagc agggcttagt gtactgatgg ctgttttggc ttccatcaca cttgtgcctg 529681 cggtcttatc gattgcaggg aagcggatga ttccgaaatc aaacaagaaa atagaaaaac 529741 aaagcactga aacaaatgtc tggggacgct ttgtcaccaa aaatcctatc atgctaagtg 529801 tatgcagcat tctgattttg atcgtcatta gtatcccatc tatgcatttg gaactgggct 529861 tgcctgatgc tgggatgaaa gctaaggata atccggatcg ccgggcatat gacttgcttg 529921 ccgaaggctt tggagaagga tttaatggcc aattaacaat cgtagcggat gccacaaatg 529981 ctacagaaaa taaggcggag gctttcgcag atgcagtgaa agaaataaag ggcttagacc 530041 atgtagcaag tgtcactcct gcaatgccta ataaagaagg gaactttgcc atcattacgg 530101 tcgttcctga aacaggtcca aatgatgtca caacgaaaga tttggtacat gatgtacgca 530161 gtttatcaga taaaaacgga gtagatttgc ttgttactgg atcaactgca gtgaatattg 530221 acatttcaga tcgcctgaat gatgcgatac cggtgtttgc tgtacttatt gttggctttg 530281 cgtttgtatt gctgaccatc gttttccgtt cgctgcttgt gccgcttgtt gctgttgcag 530341 gtttcatgtt gacgatgaca gccactcttg gaatctgtgt atttgtcttg caagacggga 530401 atctcatcga ctttttcaaa atacctgaaa aagggccgat actcgcgttc ctgccgattt 530461 tatcgattgg gattctgttc gggttagcca tggattatca agtattcctt gtcagcagaa 530521 tgcgtgaaga atatgtaaaa acaaacaatc cagtacaagc cattcaggct ggattaaaac 530581 acagtggtcc tgttgttaca gcagccggct tgatcatgat cttcgttttt gcaggattta 530641 tctttgcagg cgaagcttct attaaagcca atgggctggc tctttccttt ggtgtactct 530701 ttgatgcctt tattgtaaga atgacactga ttccaagtgt catgaagctg atggggaatg 530761 cagcctggta tttgccgaaa tggttagaca agattattcc gaatgtggat atagaagggc 530821 atcaactgac aaaggaaata cagccggaaa tagatcatga acaaaagaaa caaatcagtg 530881 tgtaatagaa aaagcagatc ttttatgatc tgctcttttg cttatggtag tatttagaag 530941 atgaagtcgg cagttaaaag gagacgctta tggcgccatc actcattttc gatatggatg 531001 gaactttgtt tcatattggc agaagctgca tcatactagc aggcatccca ggagaagtga 531061 catgattttt tgactttgca ttcactactt gatgccaagg atcttgagaa tccttcttga 531121 aaataaagga ttttacaact gatcatataa gaaacctaaa gaaacaagca cacaaaacca 531181 gctgcgggtt ttgtccaaga aaaatagagt ccataagagg gactctattt tttgaagtgc 531241 ccggctagaa gcatattgca ggactttatg aatgcaaatc actatcttat aagcccttac 531301 cgtgaaatgc ctgtttctgc attgaaaaaa cgcattacac gttcatttac gtaagtgggt 531361 tgttccatcg ataaaacatg tccggcattt ttaatgactt ccgcctcaat atctggaacg 531421 aatgaagagg ctcggtgcag ggctgagtgg ggatcataga tgacttcatg ttcaccaagt 531481 aataatagga taggaactct tgctgaacgt aattcctcat cggtaaaaac atacggaaat 531541 ccgtcggcat taggatttgg atttcttgat ccatcctgcc acattacccc tgccttaaac 531601 tgcttcacaa aaatcgggtg cagcacattc tgatcattca tcatccaatt taagaatgtt 531661 tcaactccat ttgacgctgt aaggccaaga gcgtatttgt agaaatcgtg atgaaatggc 531721 aaaaacgttt ctgccggact cagtatagct gcgcttttta ctctctcagg catacgtaaa 531781 aggaaattca tcgtatggag accgccaagc gaaagtccga tcatgtggga cttttcgatc 531841 cccagattgt caaacacatc aagaagccaa ttggcgtaat ccgttcttgt accgcttaca 531901 ttctcaggaa tactcttgtt tttatcacct atgatatcaa ctgcataagt tctgtattta 531961 ctgctccaat cggcgatgtt gggataccac atcgtcgagc tgaataatgc tccgtggagt 532021 aatacaagcg gcggggcatc ctctgggccg cttgcaatca catgtgtttg accaaaacga 532081 gtagatatat agaatgattt acaacggacc ggccaaagac taaggctttc attataagtt 532141 tgataatagc ggataccgtt gtcacttaat tcgggaatac tagatgaatg gtttgacata 532201 caaatgcccc tcccaatttt gtttaaatga atgtgccgtt tcgtgatggg gaatctgatt 532261 ttgatataac agactttatt tacaatataa tacagttgtt attagacgtc aaatccaaga 532321 tgaaaaggaa aaaaacgatt gaaacagatt attgaaaatc aatataacag aatattaacc 532381 tcctttgtgg agccgcttca ttaaaaccgc aatccaaatg catgaatcac aaaaatcaca 532441 acaggaggga tcaggaggga aggcagcaga ttcagtgttt tgaacttctt gattccaaga 532501 atgcttagac ctgaactgag gatgagtatg cctcccacaa ttgtgatttc attaataagg 532561 tctgtattga ttgcgctctc cattacttgt gcaaataaat agatggagcc ctgccaggaa 532621 aataatacaa gtgcggcagc cgctattcca aaaccaaaag ttgaagcgag cacaatggag 532681 gtgatcccat ctaacatccc gtttgtcaga aggtatgtat aatctccatg caaagcggct 532741 tcaacagggc ctaatattga cagcgaacct atacaaaata ataagaccgc agttgataag 532801 ccctctgcta aattgctttt agaaaatttg ttcaccagct tgttgaatcg taattctaaa 532861 ttgatgatct ggcctagcaa acctccaatg gctaaactca cgatgaatag aatggggtat 532921 ttactatcag gcaaatgctg tgtaatggcg ttgatcccca gtgcgaccgc agcgaatccc 532981 attgcctgca tcaaaatatc ctggtattca tctttaatgc cttttttgaa tatccccccg 533041 attatgcttc ctgcaatgat catcactgtg ttaaaaatcg ttccaaacat aagctttctc 533101 ctccaaaaat cattcctgca taaaaaataa accctctagt tagtagagag tcaagggaga 533161 tcaaaacata ttcatgagat tatttgatgg gcagcaggat ttcagtcacg taattatcta 533221 ggttattcgt aatgccataa tcaatgagtg tgatttcgat tgagtcccct gctacctcat 533281 aatgatgttc tttcatatat gccagtaatt ttttgtagta tggttcggct tctggatgtg 533341 accctttaaa cctaatttgc agatattctc ttgaaggaaa gatgatttct gaagaagttt 533401 tttcattttc atcttcaaga atcataaata tactggaata tttgtcaaac tgttttgctt 533461 tcacatttgc tgcagaaatg gataaaccaa tcttgcctat gaatatatct tcgtttacat 533521 tcaggtgggt tctcaattca gctaacgaat gttcgatatc atggccgaga acatattcat 533581 gctgcaaata ggccacacgc attgcgggaa gtttgatttt tgaaatttga tgtaacggca 533641 tgttaacggc atcttctata tgtgtgatgc gtcgggagat ctttcgttca atgcgttcca 533701 attctttctt cttgcgatca atttcaacct gctggctttt tagtaaatga agaagagtgt 533761 ttgtattttg agagttataa aaatcaagaa gcttattgat tggcaggcct agggccctca 533821 aatacttgat ggtatccagc cgctcaaact gttgggtaga ataatatcta tagttcgttt 533881 gctcatcttt atattccggt ttcaaaaggc cgatttcatc ataataccga agagcagaga 533941 ttttcacatt gaataacttt gacacttctc caatcgaaaa aaattccttc attctaacaa 534001 cctttctgtc ctatgattga tatacacaca ttatatagta cggcgagtac taaaggtaaa 534061 gtttgcagca taaagaaaaa actccttcta aaaaggagct tttcattctt cgaaataagg 534121 atttacatgg atgagcactt cttctacatc tgaaaactgt cttttgattt catttcgaat 534181 ttcgcgggca atgtcgtgtc cctgcttaat tgtcaaatca tgatccaaag ataaacggac 534241 atcaagcaat ttatagtggc catgttctcg cgcgcggatt ctatcaattc gttttacctg 534301 atcacattga aaaataacag ctttatattc ctctatcagc tcgggatcaa cactcttttc 534361 catgagcaca tcaacagacg gcctgattaa ttccattgaa atcttaaaaa tgaggtaagc 534421 aacgattgca ctggcaatgg catcggcgta caacagatag gaccatccac ggctgtttcc 534481 gatgatagcc aacaggacgc cgataaaagc ggcaagagag gcaacgatat cgcctttatg 534541 atcgtacgca atcgctataa tcgctttgct gttccatttt ttcccttgct ttatagaata 534601 acgatataag atttccttag ccacgtacga aatcagagcc gcaaacaatg cgctgtattg 534661 gggaacgctt ggccctttaa caaaggacag aatcgcttct atgaggatat aaacggatac 534721 gatcactaag ataattccta caatcgcctc actaatgact tcagcttttc cgtgaccaaa 534781 aggatggtct tgatcgggcg gtttattgga aattccgatc actgccaaga ctgcaatcga 534841 agcaacgaca tctgccgcgg aatgtattcc gtctgcaaac acggcttcac tatcgcctac 534901 cagcccaaaa aagacctttc ctgccattaa gatcagattg gcgatcaatg caatcaaagc 534961 aacttttctg cttatttgtt ctctttcact tgccattttt tcctcctata aaactgcaca 535021 aaaaaatagg agtgctctat atacgctctc cgtatccttt cctgtgtaat cactttgttt 535081 atcataccaa ttcaatttcg agtgggtcta tagcaacgtt gtttcctgtt tactaataaa 535141 taaggtgaca gaaaaaaagt tggagctatg ctaaaaaggt catacagcaa acaaatgagt 535201 tcttatgtaa caacagtgat gattcgctat taaaatgctg ccgtcagtga aaaatttcca 535261 cctaattttc aaaaacctat tgacatgaga agatctgtat tttactatta tctcatattc 535321 aagatatttt aatttgagat atttggtcgg aaagatcagc gatcaagcgc aactctaagt 535381 gttcaatcgt tgtcagttct tttacacaat attcaatatg attttttata acataatatc 535441 tcgaattcga gataaaaggg agtgtagcgt aatggctgaa tttactcatt tagtcaatga 535501 aagacgatct gcaagcaatt ttctttcagg tcatccaatc acaaaagaag atctcaatga 535561 gatgtttgaa ttggttgcat tggcaccatc ggcttttaat ttgcagcata caaaatatgt 535621 gacggttctt gaccaggacg taaaggaaaa gctgaagcag gccgcaaacg gacaatataa 535681 agtggttagc tcttctgcgg ttctcttggt attaggggat aagcaggcat atcaacaagc 535741 ggccgatatc tatgaaggtt taaaggtatt ggggatatta aataagcaag agtatgacca 535801 catggtgcaa gacaccgttt cgttttatga aaacagggga gaacaattta agagagatga 535861 ggcgataagg aatgcttcac tttctgcgat gatgtttatg ctgagtgcta aggaaaaagg 535921 ctgggatacc tgcccgatga tcggctttga tgcggaagcc gtaaaacgga ttttgaacat 535981 agacgaccaa tttgaggttg tcatgatgat tacgattgga aaagaaaaaa cagagagcag 536041 aagaccgcgc ggctaccgga agcctgtgaa tgagtttgtt gagtatatgt aaaaggagcg 536101 gataaaaatg gctaaaaaaa cgatgggaat tcatcatatt acagcgattg tcggtcaccc 536161 tcaagagaac acagattttt acgcaggagt gcttgggctt cgtttggtca agcaaactgt 536221 caattttgat gacccaggta cgtatcatct ttattttggg aatgaaggcg ggaagccggg 536281 aacaatcatt accttctttc cgtgggccgg agcccgccaa ggcgtcattg gagacggtca 536341 agttggcgtg acttcgtatg tcgtgccgaa aggggctatg gcattttggg aaaagagact 536401 agaaaagttc aacgttccct acaccaaaat cgagcgcttt ggggaacaat atgtagaatt 536461 tgatgatcct catggactgc acttagaaat cgtggaaaga gaagaaggag aggctaatac 536521 gtggactttc ggagaagtaa cgcccgatgt tgccattaaa ggttttgggg gtgcaaccct 536581 attatcagag cagcctgaca aaaccgctga ccttttagaa aacatcatgg ggctggagcg 536641 agtcggcaaa gaaggagact tcgttcgtta tcgttccgcc ggtgatatcg gaaatgtgat 536701 tgaccttaag ttaacgccta ttggccgcgg gcaaatgggg gccggaacgg tgcatcacat 536761 cgcttggcgg gctaacgatg atgaagatca gttagattgg caaagatata ttgcttccca 536821 cggatatggt gtaactcctg ttcgggatag aaactacttt aatgccattt acttcaggga 536881 acacggggaa atcctgtttg aaatcgcaac tgatccccca ggctttgcac atgatgaaac 536941 acaggaaaca atgggcgaaa aactgatgct gcctgtgcaa tatgaaccgc atcgcacaca 537001 aattgaacaa gggctgctgc cgtttgaagt aagagagtta gattgatttg acacataaaa 537061 aataaagaaa catatattca attgatgatt gctggatggt actgtcagca aagaatcaga 537121 taaaatcaaa gatgaggaga gatacaaatg gaagatgcag gactgttgct tattcgtata 537181 atgattggtg tggtgttttt gttttatggc acacaaaaat tattcggctg gtttggcgga 537241 tacgggatta aaggaaccgg acaatggttc gaatcaattg gggtgaaacc aggaaacgtt 537301 gcggccgctc tatcaggtct tggggagtta gtaagcggaa ttctatttat tttaggcgta 537361 ttcctcccgc ttggagctgc tatcataaca atcatcatgt taggtgctat cgtaaaagtc 537421 catggagcga aaggttttgc gaatggcgcc ggaggttttg aatataacct ggtgctcatt 537481 gcagtttcca taggggttgc actcatcggt tcaggagctt acgctttgca tttttaatac 537541 gaaagtatgt aagaacagtt gctgcttgtc agtaactgtt cttttatttt cacattttcg 537601 gcaagcttgc aggtactctg caaagcaaaa aagcggatat cataaatata aatctgtata 537661 gtgaatgata cgtattgatg agcttggtca tgaaaaacag acctatttga aggagtaaat 537721 ggatgaaaga gatgacagga ttacattcat tagtttctat agaaaacttt atcaaacagc 537781 acaaattcag ttttatttat atatcaaggc ctggctgtac agtatgtcac gcagttctgc 537841 cccagctcag aatagtattg gatcagtttc caaacatcaa attggggcat atcaatgctg 537901 acgatgtagc agaggtcgcc ggcagatttt cagttttcac cgttcctgtg cttcttttgt 537961 tcattgatgg gactgagttt ctaagagaag cccgttttgt tcattttgaa cagcttgaac 538021 aaaagctgaa aagggtttat cgattatatg aaggcgaata aaggaataag gcaaaaaaag 538081 aactcaaatg agttcttttt ttattcttca ctaggcgaag aagggttatc aacctgccct 538141 tgatcacttg tatcattatc acaacttgct gaaataataa ttgaatgaga aggagagtaa 538201 tctcctaatg tgaaattcac tccgtaattt ttgctgttcg cagtatggct gttttgcaag 538261 ttttgtccga tatctgtatt ggcgttttgt gtcattccat ttatcgtgag atttgagatg 538321 ttgatttgag atcgcatgct tcaaaaactc ctttcactca gaagtagctg tcataaagga 538381 cgctggcagt ctatttactt ctatgatatt gcgtttttat atcattgcat caacataatg 538441 gtaaaaataa tagcgagtga atgatcatct tttgaagatg atcaacctat cagcagaaat 538501 aaagccgcct gataaagagg cggcagatcg ttatatgtca tctatgaatt tgatgtatcg 538561 tttttcgttt gcctgaagga taagatagtc gtttttaatg atgagtagga gcctatagca 538621 gcgtagccat aaaaccagcc cataaatacg ccagaaaaga ggctgtgtcg atggcttatg 538681 aaaacagaaa tgacaaggcc tgttattaag gcaactgacg gtacaaaagt tttggggatt 538741 ttcaataata ttttgaggat ttgggttatc aatatgatga ttggaacagc tatcacagca 538801 tcccaaaagt tcgtgtgaat aattggaaaa gccatacggc acctcatgaa gtgtttattt 538861 cttaattttt acgctaaaag cttggaaagc agctcttgga tcgcatatgt tacattttgg 538921 gcttgattgg cggagcttgt ttggcttaaa gcattggatt caaaaaccaa acctgtatta 538981 ctcccaccgg aaccctctgt tgttttagac acagagaacg ggctgatgga aactgcaaat 539041 ccgttattaa aaacgctgtt cccggatatc gaatgaatat aaactgggaa tttcatcatt 539101 catctctcct ctctgttatg actgtttata caatatggtg tgtgagcagc agttgcttaa 539161 acaaaacggc aaaaactttc agtaagagac aaaaacctgc aaaatgccac aagcgccttt 539221 tgttaatgca gctttttagg gacgtttttt ttattttttt tgccaacttc atcaaaaata 539281 ttctgattgc cagactgggc ttgtccgtcc ttatttatga aatcggggtg aatgagtttt 539341 ttcagatccc tgactgttaa aggcttggcg tcatcagtta attctattcc taattgcccg 539401 tttgcctcta atgtcgcaat tttgacatct tgtatagccg taacgccgtg aagccttagc 539461 tgcatttcaa gctggtcagc tgtaagtctc atcttcttta agttttcgat atgaagctgt 539521 ccgttttcaa tgacgatttt tgcttttccg gttaacatct tttcaatggt gttcgatttc 539581 atttggatcc attccataac gatgagtgtg cttgtgaaaa ttgccgctgc aattaatgtt 539641 ttgaagaggc tgtactcgat gattggctga acgataatag ttccgatcga aatcatgaca 539701 accgtttgag tcgacgtcat ttgtgcgatt gatttccttc ctgaaattct cagcaaaatg 539761 accccggcta caatgagaac aagagattcc caagtgaaat tcatgctacc acctgaccaa 539821 tgatgaatta gatttgtcat gggattggct tttcttccgg ccaatcgcaa tttaatatat 539881 ccgaaaggca gtcggttcat tctgtcctga accgaacaat atttttggta tagatggata 539941 tattaagcca aacaatgata gcaacaggag ttttttggcc gaaacaatct gggaagcggg 540001 gagcgccata acatgattga acttgaagtt gtcattagaa cggttgccag ctttggcttg 540061 ctgttaatcg cagaacgaat tttaggcaaa cagacaatct ctcaaatgac gatttttgat 540121 tttattgcgg cgatcacact aggggcgatt gctgccggat tagcttacaa tacttcaata 540181 aaaccgcaca atatggccat ttcgtttagt atttttgtgc taaccatttt tctaatttcg 540241 tttctgtcga taaagaacag gaagctgagg aaattttttg ccggagatcc aacagtgctg 540301 attcaaaacg ggaagatact tgaatcaaat atgaggaaaa tgcgttacac acttgattat 540361 ttaaatcagc aattacggga aaaagaaata tttaatatcg aagaagttct ttttgccatt 540421 cttgaaacga atggtcagct gactgtgtta agaaaaccgc aattccggca tgtgaccaaa 540481 caggatttaa tgattgcggt aaaccaagaa caaaggcttc cgatagaact tattatggac 540541 ggagaaatca ttgagaataa tttaaagcag aatcgtttga cggaatcctg gcttttggaa 540601 gaattgcgaa aaagagacat aaaggtgaaa gagaccgtgt acgcagtgct gctgggtaat 540661 ggggatattt atgtggatca atataaagac catatatcag tccctatgga taaggaatga 540721 aggaacaatc aatcttaaag ccccttattg aacgcaacgg tttcaacttg tcttgggtac 540781 gaaatatgca gaagcccgtt taacagctga atctgtaaca aatgagtttc agcggcttcg 540841 ggaagctgaa tgattcgctc aatttctccg taataccgtt cacgcagcac ttccatttcg 540901 gctggaaaaa caggcgtgat cgttcctttg atcagcagct gggttttaga cagtaaacgg 540961 atcgttaatt cttcctcata cacaccgggc atttccacaa tgataaaatt atattcctca 541021 tcttgataaa agtcgtaaac aaacgtagaa gcttcggaat caaaaaaatg ttccggggct 541081 ttatatttga gcacatttgt ccaaaagtca ctttgtttat attcattcgt aatctcaagc 541141 cactttcgaa ttttttcgaa atccatatga gattctcctt aaatttgatt tgaaatcggc 541201 gcagaagggt ttccgatttg gtcttggtca ctaacgtctg aatcaatatt tccagtgttt 541261 aaaagtgaag acgtaggcga aagatcccct aaggaaaagt ttgctccaaa atatttgctg 541321 ttcgcagtat ggctgttgtg cacagtcgga ccgacatcta tatttccgtt ttgcgtgacg 541381 ccgttgatct taatatttgc gatattaatt tgatatggca tagacgaaac ccctttaatc 541441 taaaattggc ggtggtgcaa tcggaggagc attaacgttg gatgtatcag agttgccgat 541501 agatgtctgg tcatttacat caggatcgtt taagaagttt tccattacgg attctgtagg 541561 tgatgtatca ccgaaagaag agttggtccc ttgagatttt tgattgttgg tagggctgtt 541621 ataagcagct tcgcctattg taattgaacc attgcccgaa atactgttga tcttcaaata 541681 atataggttg attactgtag acggcatccc atcacaccct tccatctttc tgtacagtac 541741 attatgcgcc gctgcaccca attgttcctt gcatttacgg gcaaaactct atctggcccc 541801 ggagtgatgc tcaattatca gtgaatgaaa agccattgat ataggaatca atgaattgat 541861 tcagttattc gaaatgcatg agacctttta ataaaggaag ctggcaaaca ggatcagttt 541921 gaaataattg acaatgaagc taatgccatg aaataatact cgtgagtaac attactcgtg 541981 ggtattattt ttggggtggt cctagttgaa aagtaaagga gtagaaagcc gaaaacgatt 542041 acttaaagct gccgctaatg aattttcggt tcggggattc catgacgcga aggtaagtga 542101 aattgtgaaa aaagctgggt tcacgcagcc ttcattttac ctgtactttc aaagcaaaga 542161 agccatcttt gccgagttaa taaccgattt tcactctcga gtcagaaagc tgacagagtc 542221 acttcttctg gaaaacggat taaacacgga ggatgtgtca aaacgggtac tgctagctgt 542281 agagactgtt tttcaatttt tggatgagga caaggattta accaagatcg gcttttttct 542341 caacccggaa gcaaaacaaa tgaaaaaaga cttggcgatg gttttgaaag agaacttaga 542401 agcagaacag cggcttggct attttcactc tgaactggat atggaaactg tcgctgagtg 542461 tttggtcggc atgattgaac atttaaccga atcatttttg ttaaccggaa tcaaagatcc 542521 ggcaagcctc gcagcagagg ttgtgaatct tttaatttac gggatgcttc cgaaagggaa 542581 tgatgtaaga tgatatctat tatgatgaaa gtcagtttgg cagtttttat gcttgcggga 542641 ggcatcataa aggtaagccg cgttcccttt caagttgagc attggcggca ttatcaatat 542701 ccattatggt ttctgactgt tactggcatt cttgaaatag ccggggcact tgctatgaca 542761 gcgggaattt ggaatcggta tgcagcaatt ggagcaggtg ttctgtttgt cgttctcatg 542821 gcgggagcaa ttcatgcgca tatgtttcga gcaagacaat ctgtcatcat ggcgatacaa 542881 gcgatgattt gtttgattgt ttcaatcatg atcatcatgg ggagttacac gtaagctttt 542941 cactaatgtt taagaacaag cccatttgca ggaaatctcc ttttcttatc gaataataga 543001 aagtccagga attaactgaa tcagtaaaat agagctccat ttctgtgtta ttcgtccggc 543061 atcagctggg ctttttttat aaaggaggaa tacaggatgg cattcacttt ggaagacatg 543121 actgaggaag agttcgaagc ctttcgcggg atgtccgtgc aaaattttgc gaaacaaaac 543181 ataacgtcag gaacttggac ggaaaaagag gcatttgaga aatcggagca ggcatatgag 543241 aacatgattc cgaatgggcg agacagcagc aatcattatt tttggaacat cacaaatgac 543301 caaggagaaa gaatgggctg gctctggctg tatgctgatc cattacatcc gcaaaaggaa 543361 gcgtttatct attcctttgg attgtatgaa gcctttcgcg gaaaaggact tgctcaattg 543421 gcgcttcaaa cgcttgatga aagagcaaga gagcttggtg cggaaaggct ggctctacat 543481 gtatttgcac acaacgagac agccgtctat ctttatcaga agatgggcta tgccatgacc 543541 aatatacgta tgcggaaaca gctatgctga aaagccgctt acgttaccca aatacaacat 543601 gcctatctgg aagcggtggc agggtactat aagtcatcat tagaaagatt aaggtcatgg 543661 gaggcttgaa catataaaga aaaaggacaa cagctgttgt ccttttcaat gccgcttgaa 543721 ctttctccct cagtcttttt tgtcttgatg atccagctct tttattcgtt tcgtaagctc 543781 attgaaagcc tgatcaagct ccttataccc tttatcattt ggcgtcataa aactgagctt 543841 tcccagcact tcttgtcttt ctgtctcaag ctttaaccga agctcctccc gctcatttct 543901 ttctgaagga acgtcgttta actgcttttc gatgccgttg tttgagatga cgagtttact 543961 gtttgttgtt ttttcgagaa agtatcggtc atgtgaaacc gccagcaatg tgccgctgta 544021 ttgtgacagt gtttcttcca gctgttcgcg tgacggcagg tcgagatggt ttgtcggctc 544081 atctaaaatc agcacgtctt tttcctccag aatatatgcc atcagcttga tctttacacg 544141 ctcacccata ctcatatgct tgatcggttc agtccattgg gcggctgtaa aacctaagtg 544201 cctcatcaga ttttgaacgt gcccccttgc tttgaatgtt tcattctcaa ataactcttc 544261 cggtgtttgt tctaaaggca aatcaaacac ctcctgcgtt aaatagccga tgtttgcgga 544321 cggcgacacc catacacttc cttctgctgt ttcctgtccc agaatgatgt tcagtaatgt 544381 cgtttttccg ctgccattgg ggcctatgat cgcaaccttt tcgccgtgct gaattgtaaa 544441 gtttgcgttt ttaaagagag tcctttctcc aaacgctttt gttacattct gaacttctaa 544501 aaaacgtttt cctgttttgt gggttgtatc gattgaaaag cggactgtat attctggggt 544561 aacgggttcc gcctttgctt tttcaagctc tttttcaagc cgcttctgct tggattttat 544621 ctgggcatcc gtacgcttcg cttttacccg gtgatattct ttaaaccctt cctttttcgt 544681 cgattgagca tgggcttttt ccgaccaaga agcgagccca ttcatttgtg cttcaatccg 544741 ttcaaccatt ttttgctgct tttcatattc acgctgctgg gtgagtcttt tcttctcccg 544801 gaacttcata tacccggagt aattcccttt gaattcaatc agcgtctgat cctcaagcga 544861 ccatattttt gttgcggctt cgtctaaaaa atatcgatcg tgagaaacga gaatcacagt 544921 gccgttataa tgtttcagct gttggatgag aaattgcaag cttttttcat caaggtggtt 544981 tgtcggttca tctaacagca gcagatctgc atcctctgat agtcctttcg ccagccgcgc 545041 tttcagtttt tcaccgccgc ttaactgatg aaaatcacga agaggcacat gccatttctc 545101 cagtaacttc ttttcggcag gtgtctgatc cgcaaaggaa tacgccgcgg tttcctgttc 545161 aaccaaagcc agttttatat ccttccgaag gatttgaccc tgtgcagggg ctaagtcatt 545221 gtgaatgagg tgcagcaacg tagatttccc agcgccgttt ttgccgataa tcccaatgat 545281 atctccttgc tgaacactgg cgtttacatg tttaaaaaca gtttgatcct ttacttcata 545341 gctaacgttt gttaatgtta cgatctcttt catccatatc cctcgcttta aagggagaat 545401 aaaaaaatcc tcccaaatgt gttggaagga ttagccgtgc ctgtgcatga tcaaataagc 545461 tattttttat aaatagcagt gtcgtatata tagaaaatgg gcagactaat cctatttttt 545521 gatttgaaat attgatttca aacggtaaaa ataagattag ttaatcattg tccacccatc 545581 atcccttctt gttttgatta caaacactat agcatacctt taaattcaaa agcaaaggtc 545641 attttcatca aaaaaactcc tgctctcatt tttgaggcag gagttttgag tcttattgat 545701 gcttcgcttt tctcacttta taaatcacaa tcagcaaaat aaaccaaacc ggtgtgacaa 545761 ataaggaaac acgagtatcc tgtgccagtg ccagcacaac cagaacaaac gccaggaacg 545821 caagaatcag gtaatttgta aacggataaa gcggaagctt aaacttgttt gttttcgcta 545881 attcaggtct tgttttgcgg tatttcatat ggcagatgac cgtaatcccc caaatgtaga 545941 taaagcatac ggttgaaata cttgtgatca gggtgaatac gccttctggc atgatgtagt 546001 ttaacgtaac accgattaaa atcacgatag ctgaaaagaa taaagcattt ctaggcactt 546061 tacgctgagt cagtttcgcc attgactcag gcgcattgtg atctttcgcc agggaataga 546121 ccatacggct tgtactgaat acagcgctgt tgcatgctga agcagcggat gtcaacacaa 546181 caaagttgat aatacttgca gccccgacga tgccaacagc gacaaatact tgtacgaatg 546241 ggctttcgct gggattgatg atatcccaag gatagatgct cataatcacg agaagagccc 546301 cgatataaaa aagcagcaca cggacaggaa tattgttgat cgccttaggg attacttttt 546361 cagggttttc tgtttcaccg gccgtaagcc cgacaagctc aatgccgaca aaagcaaaca 546421 caaccatctg gaacgagagg ataaacccgt gcatgccatt cgggaacagg cctccgtggc 546481 tccagaggtt tgtgaagctg gacactcctg agcttgtgga aaagcctttg aaaatcatca 546541 caaggccaat gacgattaac gccaaaatgg caatgacttt aatcaaagcg aaccaaaatt 546601 ctaattctcc aaaaagcttg actgtcgcca gattcataat cagtaaaata ataagagcga 546661 ttaagccagg cacccattgc ggcacacccg ggagccaata ttgagtgtag agcccgactg 546721 ctgtcagatc agccatcgca atggaaatcc agcagaacca atatgtccag ccggtgataa 546781 aagctgccat atcgcctagg tagtcttgta caaaatccac aaaagagtga tagttcaagt 546841 ttgataacag cagttcaccc agcgatctca taattaaaaa gcaaatgatc cctgtgatca 546901 tataagcaaa taaaatcgaa ggtccggcaa aatgaatcga tttgcccgag ccgagaaata 546961 agcctgtccc aatggctccg ccgatggcga tgagctggat atgcctgttt ttcaagcctc 547021 tctgcaacgt ttgctgattt atattgtctt tcgtcatgtc gtctgtcact ttatgtgttc 547081 ctccattgaa aattgtttat tgagtcagca atctattttt aatgattatt ataacactaa 547141 aatttctatc ttttttacta aaaaaggatt gatgaaaaga attttaatgt gatttggact 547201 atttcccgaa aaaagcggct ccatttaggg agccgctttt ttatgctttt tcagtttttg 547261 tcataaacag gtagagcccg taatctgtcg gtgcggatgc gtagcctgcc tgccgcagca 547321 ttgctgtgat attgccgcgg tggtatgtcc cgtgattgac aacgtgggga agcagttcgg 547381 aaacagttgt tttcatgatt ccgcttgagg gattttgaat ctggagtggc ttattgagct 547441 gttctttttg ctgtaaaaat agtatatagc gctcggataa cctcagaaaa aggtcttcca 547501 tttcctctat ttctttagcc tctgtctgtt ctttaagctg ttcagctaaa gccaacgcat 547561 cgctcaaggt tttgccggaa aacacttcaa tccagccgag atcagaaaga taaacatgag 547621 acaatacatg ggatattgac ggaaacacgc tttgaatttc ttgatggtat atctcttttg 547681 gaagctcttt taatcggttg aatatttgtt gattggccca gacgttatat tcatacaatt 547741 tgaatgcaaa atctgacatg ttaaaattcc ccctttcgtg tgtatagctt tcattataca 547801 cgaacatgag ttcttatgta gagtgctcga aaataaaatt tgttgacata tatagtttag 547861 aggaataaac taattgacat tgaacataaa gtttagcggg gtaaactata atgcgtctga 547921 ttagagctca tttcataaat tcttgttttt tgcagcacac ctgtcgactc aagaagcagg 547981 ttatccagca ggtcagtaat taagtttccg tggttataca cccacgaccc gttccacgga 548041 ttgccccctg catcaacagg aagggaactt tgcgctccaa taatataatg atgaggatta 548101 gcatgtttaa ccgcttcatc aagtggcgct tgatctgtac cttgactgcc gacaccttca 548161 ccgcctgatt catctaataa agcattgatt gtgttttgaa ccagttcaac gtgggcaatc 548221 tcctctaaaa aaatgccgcg aagcagatcg cggtactgtt tctgctttcc tctgaaatta 548281 gagctttgga aaaaaactgc atcattgtac gcatttctcc gtaatgaccg cctaatatct 548341 cctgcaggac cttagcagct gccgggtctg gcttgtccgg tttaatgata ttaatcagtt 548401 cctctttgta gtaatacata acacgcctca tttcttctta agagattttc ttatattatt 548461 tgtaagatga gataaaatat atacatgata agcatgggaa ggcgtgaaag aagaaaataa 548521 aaaaatacag gaaaagtgtt gaccaaataa aacaggcatg gtatattatt aaacgtcgct 548581 gatgaacagc gtgaaacaaa acagaaaaac aaaaaagttt tcctaaggtg tttacaagat 548641 tttaaaaatg tgtataataa gaaaagtcga attgaaaaag attcgaaaaa acattaaaaa 548701 acttcttgac ttcaacatca aatgatagta tgatagttaa gtcgctcaat aagcgcccgt 548761 agctcaattg gatagagcgt ttgactacgg atcaaaaggt taggggttcg actcctctcg 548821 ggcgcgccat ataagatacc acgcgggtgt agtttagtgg taaaacctca gccttccaag 548881 ctgatgtcgt gagttcgatt ctcatcaccc gctccattat tgaatgatct ttgaaaacta 548941 aacaagacaa aacgtacctg ttaattcagt ttttgaaaat cgcacagcga tgtgcgtagt 549001 cagtcaaact agggcctgca cgatgcaggt cacacaggtg tcaccgcggg atgcggtgga 549061 cttaacctgt gatccattta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc 549121 gtgcctaata catgcaagtc gagcgaacag atgggagctt gctccctgat gttagcggcg 549181 gacgggtgag taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg 549241 ggctaatacc ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta 549301 ccacttacag atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc 549361 aacgatgcgt agccgacctg agagggtgat cggccacact gggactgaga cacggcccag 549421 actcctacgg gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa 549481 cgccgcgtga gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt 549541 accgttcgaa tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt 549601 gccagcagcc gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg 549661 gctcgcaggc ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat 549721 tggaaactgg gaaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa 549781 tgcgtagaga tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc 549841 tgaggagcga aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa 549901 cgatgagtgc taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc 549961 actccgcctg gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca 550021 caagcggtgg agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac 550081 atcctctgac aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca 550141 tggttgtcgt cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct 550201 tgatcttagt tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga 550261 ggaaggtggg gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta 550321 caatggacag aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc 550381 tcagttcgga tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg 550441 atcagcatgc cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga 550501 gagtttgtaa cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg 550561 acagatgatt ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac 550621 ctcctttcta aggatattat acggaatata agaccttggg tcttataaac agaacgttcc 550681 ctgtcttgtt tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa 550741 cagtagacat cacattcaat tagtaataca agatatcaca tagtgattct ttttaacggt 550801 taagttagaa agggcgcacg gtggatgcct tggcactagg agccgatgaa ggacgggacg 550861 aacaccgata tgcttcgggg agctgtaagc aagctttgat ccggagattt ccgaatgggg 550921 aaacccacca ctcgtaatgg agtggtatcc atatctgaat tcataggata tgagaaggca 550981 gacccgggga actgaaacat ctaagtaccc ggaggaagag aaagcaaatg cgattccctg 551041 agtagcggcg agcgaaacgg gattagccca aaccaagagg cttgcctctt ggggttgtag 551101 gacactctgt acggagttac aaaggaacga ggtagatgaa gaggtctgga aaggcccgcc 551161 ataggaggta acagccctgt agtcaaaact tcgttctctc ctgagtggat cctgagtacg 551221 gcggaacacg tgaaattccg tcggaatccg ggaggaccat ctcccaaggc taaatactcc 551281 ctagtgaccg atagtgaacc agtaccgtga gggaaaggtg aaaagcaccc cggaagggga 551341 gtgaaagaga tcctgaaacc gtgtgcctac aagtagtcag agcccgttaa cgggtgatgg 551401 cgtgcctttt gtagaatgaa ccggcgagtt acgatcccgt gcaaggttaa gcagaagatg 551461 cggagccgca gcgaaagcga gtctgaatag ggcgcatgag tacgtggtcg tagacccgaa 551521 accaggtgat ctacccatgt ccagggtgaa gttcaggtaa cactgaatgg aggcccgaac 551581 ccacgcacgt tgaaaagtgc ggggatgagg tgtgggtagg ggtgaaatgc caatcgaacc 551641 tggagatagc tggttctctc cgaaatagct ttagggctag cctcaaggta agagtcttgg 551701 aggtagagca ctgattggac taggggcccc taccgggtta ccgaattcag tcaaactccg 551761 aatgccaatg acttatcctt gggagtcaga ctgcgagtga taagatccgt agtcgaaagg 551821 gaaacagccc agaccgccag ctaaggtccc aaagtatacg ttaagtggaa aaggatgtgg 551881 agttgcttag acaaccagga tgttggctta gaagcagcca ccatttaaag agtgcgtaat 551941 agctcactgg tcgagtgact ctgcgccgaa aatgtaccgg ggctaaacgt atcaccgaag 552001 ctgcggactg ttcttcgaac agtggtagga gagcgttcta agggctgtga agccagaccg 552061 gaaggactgg tggagcgctt agaagtgaga atgccggtat gagtagcgaa agaggggtga 552121 gaatcccctc caccgaatgc ctaaggtttc ctgaggaagg ctcgtccgct cagggttagt 552181 cgggacctaa gccgaggccg aaaggcgtag gcgatggaca acaggttgat attcctgtac 552241 cacctcctca ccatttgagc aatgggggga cgcaggagga tagggtaagc gcggtattgg 552301 atatccgcgt ccaagcagtt aggctgggaa ataggcaaat ccgtttccca taaggctgag 552361 ctgtgatggc gagcgaaata tagtagcgaa gttcctgatt ccacactgcc aagaaaagcc 552421 tctagcgagg tgagaggtgc ccgtaccgca aaccgacaca ggtaggcgag gagagaatcc 552481 taaggtgatc gagagaactc tcgttaagga actcggcaaa atgaccccgt aacttcggga 552541 gaaggggtgc tctgttaggg tgcaagcccg agagagccgc agtgaatagg cccaggcgac 552601 tgtttagcaa aaacacaggt ctctgcgaag ccgtaaggcg aagtataggg gctgacgcct 552661 gcccggtgct ggaaggttaa gaggagcgct tagcgtaagc gaaggtgcga attgaagccc 552721 cagtaaacgg cggccgtaac tataacggtc ctaaggtagc gaaattcctt gtcgggtaag 552781 ttccgacccg cacgaaaggc gcaacgatct gggcactgtc tcaacgagag actcggtgaa 552841 attatagtac ctgtgaagat gcaggttacc cgcgacagga cggaaagacc ccgtggagct 552901 ttactgcagc ctgatattga atgttggtac agcttgtaca ggataggtag gagccttgga 552961 aaccggagcg ccagcttcgg tggaggcatc ggtgggatac taccctggct gtattgacct 553021 tctaacccgc cgcccttatc gggcggggag acagtgtcag gtgggcagtt tgactggggc 553081 ggtcgcctcc taaaaggtaa cggaggcgcc caaaggttcc ctcagaatgg ttggaaatca 553141 ttcgcagagt gtaaaggcac aagggagctt gactgcgaga cctacaagtc gagcagggac 553201 gaaagtcggg cttagtgatc cggtggttcc gcatggaagg gccatcgctc aacggataaa 553261 agctaccccg gggataacag gcttatctcc cccaagagtc cacatcgacg gggaggtttg 553321 gcacctcgat gtcggctcat cgcatcctgg ggctgtagtc ggtcccaagg gttgggctgt 553381 tcgcccatta aagcggtacg cgagctgggt tcagaacgtc gtgagacagt tcggtcccta 553441 tccgtcgcgg gcgcaggaaa tttgagagga gctgtcctta gtacgagagg accgggatgg 553501 acgcaccgct ggtgtaccag ttgttctgcc aagggcatcg ctgggtagct atgtgcggac 553561 gggataagtg ctgaaagcat ctaagcatga agcccccctc aagatgagat ttcccattcc 553621 gcaaggaagt aagatccctg aaagatgatc aggttgatag gtctgaggtg gaagtgtggc 553681 gacacatgga gctgacagat actaatcgat cgaggactta accatatttt tgaatgatgt 553741 cacacctgtt atctagtttt gagagaacac tctcaatttg tttggtggcg atagcgaaga 553801 ggtcacaccc gttcccatac cgaacacgga agttaagctc ttcagcgccg atggtagtcg 553861 ggggtttccc cctgtgagag taggacgccg ccaagcatta cttttatcat cgcggggtgg 553921 agcagttcgg tagctcgtcg ggctcataac ccgaaggtcg caggttcaaa tcctgccccc 553981 gcaaccaaat atatggttaa ataaggagtg ccctaagggt gcaaccaaaa taatcctata 554041 caaatatggt ccggtagttc agttggttag aatgcctgcc tgtcacgcag gaggtcgcgg 554101 gttcgagtcc cgtccggacc gccattaatg taaacgaaac gatcatgttt tcgttttttt 554161 tgtgttttct tttactgtat cttctgcttg gtgtcatagc caagctttct ttatatcggg 554221 aacatcttgg atattccagc aaaattcgat aaactaggaa gagcacaaat aggcataagc 554281 agggttgaaa ggaggttttg gttcatggat gaatttgatt tgatacatag cattactccg 554341 cggaccattc accattcttc cgttgatgta ggaataggtg atgatgcagc gctctacact 554401 gcgaaacacg gcgttcagga aattgtttgt gttgatacta tggtagaaga cgtgcacttc 554461 aaattacact attcctcacc tgaagatatc gggtacaagg cgttagccgt taatataagt 554521 gatattgccg cgatgggagg cattcctaag ttttatctgg tatcacttgc ggtaccttca 554581 aaatggactg aatctgaaat caaggcgatg tatgaaggaa tgaatgaact ggcgaaacta 554641 tatcatatgg atctgattgg cggcgataca gtttctaccg ctgacaaatt agtcgttaca 554701 gtcactgtaa tcggtgaaat tgaaaaggga caggcctgtt tgcgcagctt ggcaaaaccg 554761 aatgatattg tgtttgtaac cggtgaaatc ggttcttctg cagcagggct ttctttattg 554821 ctggaagaga ctaatcctca aaactcatct gtggaaacgg attactttat ccacaggcat 554881 aaacggcctg agccaagagt aagcgtcggc agattatgct cgatttttaa acgggcagct 554941 ttaaatgatg ttagtgacgg attggctagt gaactgaacg agattgcaga agccagctgt 555001 gtttcaattg aaattgttga aagcatgctt ccaattcatt ctgatttgcc taagcttcat 555061 cctaactgga aagaatgggc tttgtttggc ggtgaggatt ttgagctgac agggacggtt 555121 tcaaatgagg agtgggaagt gttgaagcag gagtgcgcag cgcttcatct tcccattaca 555181 aagattggct atgtcaggga aaaaacaaaa tctaaagtga tcctaaaaac agatcaaaca 555241 tcaatgatct tagagaaaaa gggatataat cattttaaat aagacgggtg actcgtgtga 555301 agcaattaaa atggagaact gtaaatccag aagaaacaaa agcaattgcc aagctgacgg 555361 cagcgtttgc taaaccggga gacgtcctga cattagaggg cgatttaggt gcaggaaaaa 555421 cgacttttac gaaaggtttt gcagaagggc tgggaattac acgtattgta aacagtccga 555481 cttttacaat tataaaagaa tataacgatg gcgtacttcc tctttatcac atggatgtgt 555541 atagaatgga agatgaaagt gaagatttgg gacttgatga atattttcac ggacaaggtg 555601 tctgtctcgt tgaatgggct catttaattg aagaacagct gccacaggag cgactgcaaa 555661 ttgtcatcaa aagagctggt gatgatgagc gggaaattac ctttactgct gtcgggaatc 555721 ggtatgaaat gctttgtgag gagttaagta gacatgacaa tattagcaat tgatacatca 555781 aattatacat tgggcattgc gctgcttcga gaagacactg ttatagcaga atacattaca 555841 tatttgaaaa agaaccactc tgtaagagcg atgcctgctg ttcattcatt gctgaatgat 555901 tgtgatatgg caccgcagga cctttctaaa attgtcgttg caaaaggccc tggttcatac 555961 acaggagtaa gaataggtgt gacgttggcc aaaacacttg cctggtcttt agacattcca 556021 ataagtgctg tatcaagtct tgagacgctt gcggcaaatg gccggcattt tgacggtctg 556081 atcagcccaa tctttgatgc tagacgggga caggtgtaca caggtctgta tcaatataaa 556141 aatgggcttt tagagcaagt tgttccagat caaaatgtga tgctggcaga ttggctggag 556201 atgctaaaag aaaaggaccg ccctgttttg tttttaggcc atgatacttc tcttcacaag 556261 cagatgatcg aggatgtgct tggaacaaaa ggattcattg gaactgccgc ccagcataac 556321 ccgcgccctt cagaattggc ttttctcggg aaggaaaagg aagcagctga tgttcatggg 556381 cttgtcccgg attacttgcg gctggcagaa gctgaagcga aatggattga aagtcaaaag 556441 tagggtgata ggatgaaaac aaaagcagcg gtcagaaata tgcggcttga agatatagat 556501 cacgtatacg aaatcgaagc atcctccttt acgtctcctt ggacgaagga ttcgttttat 556561 catgagctgc tggaaaatcc gtatgctcat tatctcgtga ttgaaaagga cggccatctt 556621 gctgggtatt gcgggatttg gattgtgatg gacgatgccc agattacaaa tatagcgata 556681 aaaccagagt atcgcggcca gtctttagga gaaacgcttt ttcgctcagc tgttgaactg 556741 tgcaaagaaa aagacgcaag gcggctttcg cttgaagtga gggtttcgaa tcatcctgct 556801 caaggcttat ataagaaatt cgggatgcag cccggcggaa taagaaagaa ctattatact 556861 gataacgggg aagatgcgtt aattatgtgg gtgacgataa atgagtgagc aaaaagacat 556921 gtacgtatta ggaattgaaa caagctgtga tgagactgct gcagctattg tgaaaaacgg 556981 gaaagagatc atttcaaacg tagtagcctc tcaaattgaa agccataagc gcttcggagg 557041 cgttgttccg gaaattgctt caagacatca tgttgaacaa atcactttgg ttatagaaga 557101 ggcgtttcgc aaagctggca tgacgtatag tgatattgat gcgattgcag taacagaagg 557161 tccgggactg gtgggagcgc ttcttatcgg agtgaatgcc gctaaagcat tgagctttgc 557221 atataacatt ccgttagtag gcgttcatca tatagccggt catatatacg cgaaccgtct 557281 tgtagaagac atcgtgttcc cggcactggc attggtcgtt tcaggaggcc atacagaact 557341 ggtttatatg aaggaacatg gatcatttga agtcattggg gaaacccttg atgatgcggc 557401 aggagaagcc tacgacaaag tggcgcggac gatgggattg ccatatccgg gtggaccgca 557461 aattgacaag ctagctgaaa aagggaatga caatattccg cttcctcgcg catggcttga 557521 agaaggctct tacaacttca gctttagcgg attgaagtct gcggtgatca atacgcttca 557581 taatgcatcc caaaaagggc aagagattgc tccggaagat ttgtctgcca gtttccaaaa 557641 tagtgtgatc gatgtcttgg taaccaaaac ggcgcgcgcg gcaaaggaat atgatgtcaa 557701 acaggtcctt ttagccggag gagtagctgc aaacagaggc ctcagagctg cattagaaaa 557761 ggaatttgcc cagcatgaag ggattacgct tgtcattcct ccattagctt tatgcacgga 557821 taatgctgcg atgattgctg ctgctggtac aattgctttt gaaaaaggaa ttcgcggtgc 557881 atatgatatg aatggccagc ccggccttga attgacttct tatcaaagtc tcacgagata 557941 atagcgtgag actttttatc tgtttgttat taacagacaa ttcacaattt atccacatat 558001 ctgtgagtaa ttatagagat attgatggat aaagggctga ggtcactgtt aataaagtgg 558061 ataaattcag aatattttgt ggatagtgtg tataaagcgc ttactttgtt tatttattag 558121 gggatgttct gtggataaaa agcacctcta aaaagaggtg cttgactttt ttaatcttct 558181 tctgtggata gttcttccca ttcggacaaa agagattcca gctcctgatt aagcttctca 558241 ttgtctgcat ggatagcttg tactttttca tgatcctgat agacttcagg gtcacatagc 558301 aattcatcat tgcggctgat gttctcctca atggtttgaa cggtggtttc aatttcttca 558361 atccgacgga gtcgttggcg ctctttcttt ttccattctt tttcttcctc gtaggaacgt 558421 ttggagtcag acttcactgt agctggcgtt ttatcagttt cctcttgctg attcattttc 558481 tccaattcaa gctgctctgt ttttttctct gtataataat cgtaatctcc cagatactcc 558541 tctatatggc ttgaagaaag ctccaatact cttgtggcga ttctgttaat aaaatatctg 558601 tcatgtgaga caaataacag tgtgcctgga taatcaatca gcgcgttttc gagaacttct 558661 ttgctgtcta aatccagatg gttcgtcggt tcatcaagga tgagaaagtt ggctttttga 558721 agcatcagct tagctagagc caatcttgct ttttcgcctc cgctcagtga atgaactggt 558781 ttcagcacat catctccgga gaataagaaa tttccgagac acgttctgat ttctttttct 558841 gggagcccgg ggtactcgtc ccacagctca tcaaggacac gtttagagga agtcaactca 558901 gcctgttcct ggtcataata gccgacactg acatttgagc cgtaagaaat tgttccctga 558961 tctggtttta gggtgtctat taatgttttc agcaatgtcg atttacctat tccgttaggg 559021 ccgacaagcg cagcgctttc tcctcttgtg agcatgaatg acacttctgt taaaagcggc 559081 ggctggtttt catagctgat tgtgagatcc tgaacacgaa ggacttcatt tccgctctgt 559141 tttgtaatat caaaatgaaa gtttgcggat ttttcatcgc caagcggttt tgacatgaca 559201 tccattcgct caagctgctt tctgcggctt tgcgcccttt tggtggtaga ggctctcgcc 559261 agatttcgat ctacgaagtc ctgcagcttt gcaatctcgt cctgctgctt ttcatacatt 559321 ttcagatctt tttcatactg cgcggctttt tggtcgagat aagcgctgta gttgccgtga 559381 tactttttgc tttctgctct tgatacctcg tatacctggt ttactacttt gtccaaaaag 559441 tagcggtcat gcgaaacgat gagaatggcg cctgaatagc cttgtaaata atgctcaagc 559501 caggtaagcg tatcaatatc cagatggttt gtcggctcat caagaatgag caaatcaggc 559561 tgtgttaata gaagcttacc taaagccagt cttgttttct ggcctccgct gaggctttga 559621 acctgtgtag aatcgtcaaa atggctgaag ccgagaccat gcagcacaga tctaacatcc 559681 gcttcatatt gataaccgcc tttatctttg aattcctgct gaagacggtc gtaggttttc 559741 atgatgcttt ctaattcacc cgggtcagct gccgccattt tttcttccat agcccgcatt 559801 tccttttcca ttgcttttaa gtggtcaaaa acagtcagca gctcttcttt tatggtaagc 559861 ttagaatcca agccagtatg ctgggcgaga tatcccattg taatatcttt cggtttaata 559921 atttcgccct tttcatacga aagctggcct gcgataattt taaggagcgt ggattttccg 559981 gcgccatttc ttcctacaat ggcgatgcga tcacgatttc tgacttccag ctttatattg 560041 tttaaaatag tatcagcacc aaatgatttg gacagctgat taacttgtaa gatcatcata 560101 ttatttcacc tctgctataa taagttaagt gtagcttatg aaccagaagt cagcaaacaa 560161 tacattggcc atataagaca tagagaagaa aatagtgtat gatctgttta aggagcgttt 560221 taatatgaat ggattttctc attttaatga acagggcaga gcccagatgg tggatattag 560281 cgaaaaatct tcgactgtcc gtactgcggc ggctgtttca agcgtacaca tgaagaatga 560341 agtgtacgag aaaatacaaa gtcacgatat cggcaaagga gatgtactgg ctgtcgcaca 560401 ggtggcaggc attatggccg caaagcaaac gtcgaatatc attccgatgt gccatccgct 560461 ttcattgagc ggggtagata tatcgtttga ctggaaaata aaagaagcag aagttatact 560521 tcatataaaa gcacaggtca aaacgaaagg gagtacaggt gtggaaatgg aagcgctcac 560581 ttctgcatcg gtgtgcgctc ttaccgttta cgatatgtgc aaggcccttg ataagggaat 560641 ggtcatcggc cctactttct tgctggagaa gacaggcggg aaaaacggtg actttaaaag 560701 agaactatcc gagtataatt tggaggacca aaaatgaata aggatcaatc aaaaattccg 560761 caggcgacgg cgaaacggct gccgctttac tatcgctttt taaagaatct gcatgcgtca 560821 ggaaaacagc gtgtatcatc cgctgaactc agtgatgccg taaaggttga ttctgccacg 560881 attcggaggg atttttccta ttttggagct cttggcaaaa aaggatacgg atataatgtg 560941 gattatttgc tgtctttttt ccggaaaacg cttgatcagg atgagatgac agacgtcatc 561001 ttgattggtg tcgggaactt gggaacggca tttcttcact ataatttcac aaaaaacaat 561061 aacacaaaaa tttctatggc ttttgatata aatgagagta aaataggaac tgaggtaggc 561121 ggcgtgcccg tctataacct tgatgacctt gaacaacacg taaaagatga atcagttgcc 561181 attcttacag tgccagcagt tgccgctcaa tccattacag acagattggt cgcattagga 561241 atcaagggaa tccttaattt tacgccggcc cgtttgaatg tgccggaaca cattcgaatt 561301 catcatatag atttagcagt tgagcttcag tcactggttt attttttgaa gcattattca 561361 gttttagagg aaatcgaata gagggaaagg aggagcccaa atatgccgat cggtcctgga 561421 agccttgctg ttatcgcaat cgttgctctg attatcttcg gtcccaaaaa gctgcctgaa 561481 ttggggaaag cagcgggaga cacacttcgt gaatttaaaa acgctactaa aggattaacg 561541 agtgatgaag aggaaaaaaa gaaagaagat cagtaagtta ggatgacacg aatgaaagtg 561601 aatcaaatgt cgctgctgga gcatattgct gagcttcgaa aacggttgct gattgtagcg 561661 ctggcgtttg tcgttttctt tattgctgga ttttttttag caaagccgat tattgtgtat 561721 ctgcaagaaa cagatgaagc gaagcagctt acgcttaacg cgtttaacct gacagacccg 561781 ctttatgtgt ttatgcaatt tgcgtttatc atcggcatag tcttgacctc gccggttatt 561841 ctttatcagc tttgggcttt tgtgagcccg ggcctctatg agaaagagcg caaagtaacg 561901 ctcagctaca ttccggtctc tattttgctg tttttagcgg gcttatcttt ttcatattat 561961 attttatttc cttttgttgt tgattttatg aagcggattt ctcaggactt gaatgtcaat 562021 caggtgatcg gaattaatga atattttcat tttcttctgc agctgacgat tccgtttgga 562081 ctgctgttcc aaatgccggt catcctcatg tttttgacaa ggctcggaat tgtgacaccg 562141 atgttcttgg cgaaaatcag aaagtatgcg tattttacgc tgctggtgat cgcagccctg 562201 attacaccgc ctgagcttct gtcccatatg atggtcacag tcccgctttt gattttatat 562261 gaaatcagta tccttatatc gaaggccgct tatcggaaag cacagaaaag cagtgctgcc 562321 gatcgggacg tgtcttctgg gcaataataa aaaatccatt tctcatgcga gaaatggatt 562381 ttctttattt ttggttcttt ttgattttaa atgaaaaggc gaacatctta aaagaaatgc 562441 tgatgttgta agcggcgaac accatcagca ggatggagta aaatgaccac atgctgcctg 562501 gcgagcttgc ggcaagataa gtaaagatgc accctacggc aaagtagatc attccccaaa 562561 ctaccgggtt tctcataaaa ataatcctcc aataatcaat tgcatttgtg tgctctgctg 562621 ttcaaggtaa ttacgaacag gctcaagctg catgatgacg acgaatgtat tcatcattaa 562681 atgggcgaaa atcggcaccc atatccgttt tgttctcgca tataaaaagg caaaggtaaa 562741 gcccattgct gtatatagaa ggagatgctt caaatcagcg tgaacaatac cgaagataac 562801 cgagctgatc agtcctgcga aaaagaaatt cgttttttcg tacagcgcgc cgaaaatgat 562861 ttttctgaag atgatttctt ctaatatagg cccgacgatg gaagaaacga taatcatgag 562921 cgggactgcc tgaatgacat ccagaatcgc ttgtgtattt tctgattctc ttccgatgcc 562981 aaaaacataa tattcaatag agcctgctat tccttgagag aaaagggcaa tgaaaaaacc 563041 ggctatcgcc caaaggatag aaagtccgat tgagtccttc tgtccgtttc gcagcgtttc 563101 tttcggaacg gttctcagaa tgagcagaac aacaacgaga caggcgataa agctgataac 563161 ggaccataat ccttgtgcat gcagcatatt ttcatctgta ggctgtcctc cggcataacc 563221 gaatttaaat aacaagggaa tcgcgattaa tgcggaaaac tgcatgatga tatatgtcaa 563281 aataataaac caatactgtt ttctcaaatg gtatgtactc ctttgttaag tgggtttcgt 563341 tcatctacag ctattgtaac ataatcggta cgggggtgaa aaagctaacg gaaaagggag 563401 cggaaaagaa tgatgtaagc gtgaaaaatt ttttatctta tcacttgaaa ttggaaggga 563461 gattctttat tataagaatt gtgttagcac tctttagtgc tgagtgctaa aattacatat 563521 tcatactatt gaggaggtta tttcattgtt aaagccatta ggtgatcgcg ttgtcattga 563581 actcgtagaa tctgaagaaa aaactgccag cggaattgtg ttgccggatt ctgcaaaaga 563641 aaaaccgcaa gaaggcaaaa tcgtggcagc tggttcaggt cgcgtgttag aaagcggaga 563701 gcgcgttgct ttagaagtaa aagagggcga ccgcattatc ttctcaaaat acgcaggtac 563761 tgaagtgaaa tacgaaggta ctgaatactt aatcttacgt gaaagcgaca ttttagctgt 563821 tatcggctaa ttcttaaata aacaatactt aaaacatttg aggaggtctt gtaaacatgg 563881 caaaagaaat taagtttagt gaagaagctc gccgcgcaat gcttcgcggt gtcgatgcac 563941 ttgctgatgc tgttaaagta actttaggac caaaaggacg caacgtggtt ctagagaaaa 564001 aattcggttc tccgttaatc acaaatgacg gtgtaacaat cgctaaagaa atcgagctag 564061 aagacgcgtt tgaaaacatg ggtgctaagc ttgttgctga agtagccagc aaaacaaacg 564121 acgttgccgg tgacggtaca acaactgcaa cagttcttgc gcaagcaatg atccgtgaag 564181 gccttaaaaa cgtaacagca ggcgctaacc ctgtaggcgt gcgtaaaggg atggaacaag 564241 ctgtagcggt tgcgatcgaa aacttaaaag aaatttctaa gccaatcgaa ggcaaagagt 564301 ctatcgctca ggttgctgcg atctctgctg ctgatgagga agtcggaagc cttatcgctg 564361 aagcaatgga gcgcgtagga aacgacggcg ttatcacaat cgaagagtct aaaggcttca 564421 caactgagct tgaagttgtt gaaggtatgc aattcgaccg cggatatgcg tctccttaca 564481 tggtaactga ctctgataag atggaagcgg ttcttgacaa tccttacatc ttaatcacag 564541 acaaaaaaat cacaaacatt caagaaatcc ttcctgtgct tgagcaggtt gttcagcaag 564601 gcaaaccatt gcttctgatc gctgaggatg ttgaaggcga agcacttgct acacttgttg 564661 tgaacaaact tcgcggcaca ttcaacgcag tggctgttaa agctcctggt ttcggtgatc 564721 gccgtaaagc aatgcttgaa gacatcgctg tccttactgg cggagaagtc atcacagaag 564781 atcttggcct tgacctgaaa tctactcaaa tcgctcaatt gggacgcgct tctaaagttg 564841 tcgttactaa agaaaacaca acaatcgttg aaggcgctgg cgaaacagac aaaatttctg 564901 cccgtgtgac tcaaatccgc gctcaagtgg aagaaacaac ttctgaattc gacagagaaa 564961 aattacaaga gcgtcttgct aaacttgctg gcggcgtagc tgtcatcaaa gtcggcgctg 565021 cgactgaaac tgagctgaaa gagcgtaaac ttcgcatcga agacgccttg aactcaactc 565081 gcgcagctgt tgaagaaggc atcgtatccg gtggtggtac agcgcttgta aacgtatata 565141 acaaagtcgc tgcagttgaa gctgaaggcg atgctcaaac aggtatcaac atcgtgcttc 565201 gcgcgcttga agagccaatc cgtcaaatcg cacacaacgc tggccttgaa ggatctgtca 565261 tcgttgagcg cctcaaaaac gaagaaatcg gcgtaggctt caacgctgca actggcgaat 565321 gggtaaacat gatcgaaaaa ggtatcgttg acccaacaaa agttacacgc tcagctcttc 565381 aaaacgctgc gtctgtagct gcaatgttct taacaacaga agctgttgtc gctgacaagc 565441 cagaagaaaa cggtggcggc gcaggaatgc ctgatatggg cggcatgggc ggtatgggtg 565501 gaatgatgta ataaagggat attaaccctt atacatcaat gttttaaccg tcttaaaaaa 565561 ctagacaaag cgtgaataaa aaaagagaag gtctttcatc agtttactaa actgttggga 565621 gaccttttct ccatattagc ggtcatatga gcataaatgt ccatcgtcgt atttatgtcc 565681 gaatgaccaa attgttgctg gatttcttta atgcctactc ctgcctcaat tagtaaggag 565741 gtatgggtat gcctaaaaga gtggggggtg acattctttt tatcccagct tttttgagca 565801 gccgtttaag tctagtctca ataacctttc ttaattgcgg atgaccatcc tcccgctcaa 565861 aaataaatga tgagtcttga taaatcaatc tatttttaag cttaatttca ttttgataaa 565921 ttttattttt ttttagtaga ttgacatcgt ttcatcaatt cgaacgatat caacagatcc 565981 tgttgtttta ggtgttagca attggtattt ttcaatttga ttgttagggg tgtatagggt 566041 ctttgtgacc tggcttatca ttgaaatctg tccattttaa agcaagaagt tcaccaattc 566101 ttaggtcggt ctaggcaagt acggtaaaga ccaaatggtc catttctagc ccgtcagatt 566161 gagcgagctt tagaaaatgt gtcagcacct ctttttccaa tgctttgttg cttcttgggt 566221 aattgaaaat ccccagttgg gttcatttta ataatccctt gagttttagc ttttcggaaa 566281 atcatacggc cgcaggcatg aatacctccc aaacaattgt gactgtattg ctcgttcagt 566341 tctaacgtgc ggtcttcata catttttttg tgttttgcta atcgggtatt gacccaatac 566401 tgcgataaaa tgcatcattt tcttttcact ggcccgtaca ctgcttattt ttaccccact 566461 ccggttgtaa atcttaagcc aaccttttgc aaatgttttg aagggcatat ctgactcctt 566521 aataaaagtc ccgttgtcgt tttggagttc tacgtgacgg gctgctactg gggcttcttt 566581 ctttgtttta aatcttcctt tggatatttc tagacgtttt ttggttaaag ggtcaatgcc 566641 tagtagatat gataactcca cgtcttaccg cattgcttga gttttgccat ttatttgtcc 566701 ctaactaatt ttttttcatc aaattggtct ttaagtgagt ttaataattt ttgtttctct 566761 cgactggtca ataattgccc ttcatatttc aaaagattgg ataaatttga gatggaatca 566821 atcctgatgg atggtaccgt agactttaat aagaaacgaa aggccaactg cgacttcagt 566881 tggcctttcc tatttataat aaagaaattg agtgagattg ctgacagaac tacgtactac 566941 tcgttttctt tagttgccct tgctaatcgt tcaacctctc cccgaatccc aatcgcaggc 567001 tcccacgaat caatcaaacg aatcgccttc tgattagatt ccaccgcttt cgttttctct 567061 cctttacgat acaacagctg cgccattccg tagtgatagt agatcagttc aacttgattg 567121 gcgttatgtt tgtcatagag catttgctca aaggcttctt ccgctttttc aaactgatca 567181 catttcacgt aagcgacacc cagattgaaa taggcttcta tcgttttttc gccgccgtat 567241 gtggagctga tttcatttgc cgcttcgtat aattgaatgg cttctacatg ataacctctc 567301 gcaaagctta agtcaccgcg aaccaataga actctgtgtt gaatggtagg ggaaatcggt 567361 tgattttcga tttcgtttaa aattgtctct gctttttcct gttgcccgtc ttttaaaaac 567421 agccttgctt tgagtgcatg tccccaaacc tttagatcat aggcatcgtg agcgtctgat 567481 tgttcaagaa tcttcagccc ggcttctatt tgctgaagcg ctccgtctaa atcattgact 567541 tccatcaatg cccagcctga ggtgtcgatt cggaagtacg cttctcgtgt gtgttggcct 567601 aagtgatggg cggcgtcggc cgctttgcgt ccgtattcga ttcgcagggg caggttgatt 567661 ctgcttagaa aatggctaat gcgggtgatg agttcgatta ggatttcttt ttgttcagtt 567721 tcacttgccc attggatgac ctttaagatg tttggccatt cttgtttcat ttgatctaag 567781 ttccgtccca gcaggtagct ccaatagata gagttgggct gttcccgctt taaatgggtt 567841 tcggcataat caatataata gtgcgcccag cgattgcggg cttctttttc atattcgtgc 567901 tgttcggaca agtgctgttc tccgtaagcg acaacggttt ggtgcgctaa gtattgtgtc 567961 ctgccttggc ttcgttccgg ctgaatcagc gcatatgacc gcatttgttc catagcgtaa 568021 tgaaaacggc gggcgtctaa tccggctgct gccgccaggc ttttttcatc aggcggcttg 568081 ctgaaaaagc aaagcgtctg ccagagcttt cgcgtatctt cattgcatct atcccaggtg 568141 cggccaaaga ggaattcaaa caattccagc agtgagtagc ctgcttttcc aagctcatga 568201 atcagctgct gagcggggat gtcatcgtct gacatatagg caatgctgag tgccatggct 568261 ttcgggtttc cggcagtcgc tgaaatgaat tcgtttttca ggtcagatga tagatgtaac 568321 agctgctcca gcttttcccg tttacgtggg aggttgcatg tttgtaagca gtgatgcact 568381 tcttgttgaa aaaattcgtg ggcatctgtt tggtcaagac cgcttagctg aatggctgtc 568441 atttctccga agctttcccg ataagtttgc tttacgtttt cccgcgctgt aaggagaact 568501 tttacgcctt gcggaaggct ggtgataaat tcatgaatgt cacgttctgc agtatcaatg 568561 ctgtcaacga tcagcaggat cggtttttct ctagtgtaat tggctaacgc attgcggacg 568621 acaaaccgtt ttacattgat tgatttatcg atttgttctt tgcgtccgag ctgataggcg 568681 atcgtattta aaaaatcgct aaagcttaat cctttccaat cagcgctgac ccagatgatg 568741 ctgttgaatg ccggccaaac tgaagtatcg tcgacacagg aataggcggc ttcaagagca 568801 attgtggttt ttcccatgcc ggcccagccg gtgattaaac agactggtga tggagaaagc 568861 atccattgcc gtatcgcttc catatcaaag ctgcgtccga taaagcgtcc ggaccagcgt 568921 gagggtaaat tatgcgtgat gggctgttct gtaagcgcat tcgtttcttg gccgggtctg 568981 tcatgaaaca gccgttttac tacattttca atttcgcctt cactcggagc cccgaataat 569041 ccgtcttttc gcagtatttt cgcttttttc aaacaggatg ctgcccatac aggcaatgcg 569101 ggtttgatga ctgggatagt ggtggcttcc agcaagtcgg tcaaccactc gatatccaag 569161 tcggtctttt cgagaatgat ccagatcatt ccgaacagtt ttccgtcgtc gattcttccg 569221 ggaatgtagt ttgcccccat ctgtccgatc cagcttttga tcgtgtttgg ggagactccc 569281 agctggagtg cgattttatc tatgtaagac tgtcctgttt tttcattctt tttccttctg 569341 actttataat caggatgaag ttttagcgtt ttgacgccag gtgccagcat ttgtgcaaat 569401 tgttttcggt tttcaagttc agccataagc ctgcacctcc tattagtact attttatcaa 569461 tccagcgttt tttgtatatg aaaaaataaa agtacagtgc cgctgtcctt ttatacagca 569521 ggaaaggctg ttgaacgtgt taaaaagcag ataaaatggg ggcagtaaca gagaaaacaa 569581 aaatgtatgc acttacattt tattttctaa agaaaggaac ttgccaaatg actcacacag 569641 tacctcaaaa catgaaagcg gctgttatgc acaacacaag agagatcaaa attgaaacat 569701 tgcctgtgcc tgatatcaat catgatgaag tgttgattaa ggtgatggct gtcggaattt 569761 gcggatctga tctgcattac tatacaaatg gccgaatagg caactatgtt gtggaaaaac 569821 catttatcct tgggcatgaa tgtgcgggtg aaattgccgc tgtcggatca tctgtcgatc 569881 aattcaaggt gggagaccgc gtcgctgtag agccgggtgt tacgtgcgga cgctgtgagg 569941 cgtgcaaaga aggacgctat aatctttgcc cggatgtaca gtttttggct acaccgccgg 570001 tagacggtgc gtttgtccaa tatattaaaa tgcgtcagga ctttgttttt ttaatcccag 570061 actcactttc ttatgaagaa gctgctttga tcgagccgtt ttctgtcggt atccatgcgg 570121 cggccagaac gaagctacag cccggatcaa cgattgcgat tatggggatg ggccctgttg 570181 ggttaatggc tgttgccgca gctaaagcat ttggggcagg cacaatcatt gtcaccgact 570241 tagagccgct gcggttagaa gctgcgaaaa aaatgggagc gactcacatt attaatatac 570301 gtgaacagga tgcacttgaa gagattaaaa cgatcacgaa tgatagaggc gttgatgttg 570361 cttgggaaac agcagggaat ccagcggcat tgcaatccgc actggcttct gtgcgccggg 570421 gcggaaaatt ggcgattgtc ggtttgcctt cacagaacga gattccgctc aacgtgccgt 570481 ttattgcgga taatgagatt gatatttacg ggatcttccg ttatgccaat acgtatccaa 570541 agggaatcga atttcttgct tcaggcattg tggacacgaa gcatctagta acggaccaat 570601 attcgctgga gcagacgcaa gatgcgatgg agcgggcgct tcaatttaag aatgaatgtt 570661 taaaagtgat ggtgtatcca aatcgctgag tgaacaggga ggatcttcgt attctccctc 570721 ttgtttactg gaaatgaaaa cggattcttg gggtgggaaa tgatgattgg aacagaaaaa 570781 gtaacggcat tgaaggcgaa gcatcagtca aaatccagca ccggcctgtc ctggtttgaa 570841 cgaatcggtt atggattcgg cgatatgtcg tataatatta tctttcagtt tgtaaacgca 570901 tacttattat tttattatac agacgtcggc ggcattcagc ctgcggtaat cgcaactttg 570961 tttcttgttg tgcgtgtgct ggatgctatt tttgacccga tcatgggatt gattttagat 571021 aaaacgaata caaggtgggg aaaagcaagg ccatatttgc tgtgggtggc atttcctttt 571081 gcgctattca cattcttatg tttcacgacg cctcatttcg gtgagaccgg aaatatggta 571141 tatgcgtatg tcacttatat tctgcttggg atgtccttta gtatgcaaac gatcccggtg 571201 aacagcttaa cggggcggat gacgaattcg gtggaggaac gaacggttct gaccacaacc 571261 cggatgattt tggtgtatat cggcattctt ttatccattt cctgtgcgac accgcttgca 571321 actgctatcg gaggagagga tcaggcgttt ggatttcaga tgacggcgct catctatgcg 571381 gctgtcagca tcgttttgaa tctatttagt ttctttactg tacgggagcg gattcagcct 571441 aaaaagagaa aaaaacaagg gatcaaaaag acgttatccg ttttattcaa aaacaaaccc 571501 ttgctcatgt taatttcatc atttttggct tttgcgatcg ggtttaatat taagctcagc 571561 acgatggtgt attattttac gtataacgta aaccataaag agttcgtgtt tatgggcacc 571621 gttttatttt tcggggcagc gctgatcagc aatttgttta ttcctttctt ttctgagaag 571681 tggggcagaa aacaagtcat gattatcacg gcagctctat cgcttatttc ttatgccggc 571741 ctgcatttta cgccgtattc ttcaattcca ctcattttca tttggctttt cgcttcggga 571801 tttttcacaa cgcctttaaa tacgcttgct tggggaatgg ttgcggattg cgtcgattat 571861 gcggaatgga aaaccggaat tcgcgcggat ggtgttgtga tttcgagcat gagctttatt 571921 aataagctgg gtgttgcgtt agccgggtca ttttcggcca tttatttagg aatcgccggg 571981 tatgtggcga atacagacca gacagttgcg tcgttgaatg cgattaaaaa tatgaatgct 572041 ttgattccgg gatttttcat tttgctttct attattctta tcgccttcta tcctttaacg 572101 gaaaaaagat ataaacacat catctctgag ctggagcaaa ggtctgcgag ataaatagat 572161 gtaaaatttt taatattcaa tgttgtattt atggcaaaaa gtaatatact gagactgtaa 572221 tctagacttt ataaatgagt gtgataatat gcgtagtcat tctgtagttt gtattgggga 572281 attgttgatt gatttctttt gtaccgatgt tgacgttgat ttaatggaag ggcgccaatt 572341 cctgaaaagt gccggcgggg caccggcgaa tgtgtcggca gcgattgcca agctgggcgg 572401 agacgccgct ttcagcggaa aagtaggaaa ggatccgttt gggtattttc tgaagcgaac 572461 attggacgct gtacatgtcg atacctctat gctggtgatg gatgagaaag cgcctacaac 572521 gcttgctttt gtttcattaa aacaaaatgg agagcgtgac tttgttttta atagaggcgc 572581 ggacgctttg tttacgctgg aggacattga ccaggaaaaa ctaaacgaag cgaaaatcct 572641 tcatttcggc tctgcgacgg cactgttatc ggatccgttt tgctcagcct atttacggtt 572701 gatgtcgatt gcgaaagaca atggacagtt tatttcgttt gaccctaact accgtgaaga 572761 tttatggagg ggaagagtct cagagtttgt aagtgttgcg aaaaaagcga tcgctgtaag 572821 tgattttgtg aaagtcagtg acgaggaact tgagattatc agcggtgtga aggatcatga 572881 aaagggagtt gcgatccttc atgagatcgg agccaacatt gtcgctgtga cacttgggaa 572941 aagcggaacg cttctttcca atggaaaaga ccgtgaaatc attccaagca ttccggtgac 573001 atcaattgac tcaacagggg cgggagatgc ttttgtcggt gcggctttat atcaattggc 573061 aaacacggat cagattcaat ctgtagatgc tgattttgtg aaactgcgtg agattgtggc 573121 gtttgccaat aaggtcggag ctcttgtgtg cactaaaatt ggagcgattg atgcactgcc 573181 gagtttggat gagattggag tttctttgta aatcattgaa gatgtttctt gaaagtcttt 573241 ggacttttgg gggcatcttt ttttattgct tacatttttg ttcaggtaaa aagttgtata 573301 ttttttgttt gaaatgtcat tttttattaa aaaagtgaaa cttttaacga taataaatag 573361 tatatgtaac aagggttacc gaattagctt taggaggaac gatataatga gtataattgg 573421 aagatttaaa gatattatgt ctgcgaatat caatgcttta ttggacaagg ctgaaaatcc 573481 ggagaaaatg gtagatcaat atttaagaaa tatgaatagc gatttggcta aggttaaggc 573541 agaaacagca gctgttatgg ctgaggagca gagagcaaaa agagaatatc acgaatgcca 573601 ggcggatatg gaaaagatgg aaagctatgc aatgaaggcg ctgcaagccg ggaatgagag 573661 cgatgcgaga aaatttcttg aaagaaaaac atctttggag tcaaagcttt ctgagctgca 573721 ggcggcgaat caaattgctg caaccaatgc cgcacagatg agaaagatgc atgacaaatt 573781 ggtatctgac attggagagc tggaagcacg caaaaatatg atcaaggcga agtgggcagt 573841 agcgaaaacg caagaaagaa tgaacaaact gggcgcttct gtttcaagta caagccaatc 573901 aatgtctgca ttcggccgaa tggaggacaa agtaaataag gcacttgatc aggccaatgc 573961 aatggctgaa ctgaacagcg ctccgcagga tgatatggct gatctgtctg caaagtatga 574021 cactggcggt tcaagccagg ttgatgatga acttgcggcg ttaaaagcga aaatgatgct 574081 cgataagtaa tacataggag gccgcagctt tcggctgcgg cgtcatttta tcataaaatg 574141 tgagagggaa cggtaatgat aatatcttat aagtgtccga actgcggcag tgatatggca 574201 tttgacagtg aaaccggctc gttatcctgc agcagctgcg gaagacagga caatattgaa 574261 agccttccga aagaaaacat tgcggcacgg ttttctgatg atgaagcaaa agaatatcaa 574321 tgtaaaaact gcggtgccgt tttgatcacg gaagctgaaa cgacagcaac gacgtgcagc 574381 ttctgcggag gtgctgcaat acttgccgat cgtttatcag gacatttggc gccggcgaag 574441 gtcattccat ttacaatcag caagcaagaa gcggagcagg catttcgaaa gtggtgcaaa 574501 aaaggccttc tgacaccaag aggtttcatg tctgctgatc gtatcaaaag catcaccggc 574561 atgtatattc cattttggat gtttgattta aatagtgaag tacaggtgag agcaaactgt 574621 accagagtcc atcaatatga agaaggggat tatatttgca cggaaacaga gcactttgaa 574681 gcgtttcgtg atatcaatct cgattatttg aaaatccctg tcgatgcctc tgaaaaaatg 574741 aaagacgaat taatggacaa attggagcct tattcatacg aagagctgaa ggactttcaa 574801 acggcatatt tggccggtta tattgcggaa aagtacaatt ataccgatga ggagcttttt 574861 ccgagggcaa aagagaaaat cagcagttat atagattcat acatccattc tactttttcc 574921 ggatatacgt cagtcaatgt gagggacaaa catattcaca cgaaaaacgt gaacagcttt 574981 tacgttttgc ttcctgtttg gatggtcagt tacgattatg aaagagcgga gcatatcttt 575041 gcgatgaacg ggcaaacagg aaaggtcgtt ggaaagccgc cgatcagtcg aggaaaagtg 575101 gctgcatggt ttagcggaat agcaggcggg acatttcttg cgttgaagct cgtctcattg 575161 atgatgggag gcggattttg atgcgtggat tttttgggaa agcgatcttt gttgtgctgg 575221 ctgttttcat catgatgcct ttactgggta tcgaagcggt aagagcctct gaattgcagc 575281 agcatgtgta cgatcgcgct catctattgt caaaagcgga gatcggaaaa cttgaatctc 575341 tctcggcaaa gctgggtgca aagagggaca ctgatttcat cattattacg accaaaagca 575401 caaacggtga agatattgca gactataccg gcgattttta tgatcgttac ggaaaaggca 575461 gtacagccat tctgacgatt gatatgacaa acagagaagt gtttatcgca ggctttaaaa 575521 aagccgaaca gtatttggac aacagcaggc tcaatagcat cagaaatacg atttcatctg 575581 atttatccaa tgaaaattat tttgaagctt ttgagacata tattcagctt tcctataaag 575641 atatgggcat aaaaccggga gtaaaccctg acaacatatt ctttacatgg tggtttcagc 575701 tgattgctgc catcgcagtc gggggaattg cggtttcaat catgctttat catgcaggcg 575761 gcaaagtaac ggttaatgga agtacatata tggatcagcg tacgtctgat gtgattgatc 575821 aatacgacac ttatattaga acgactgtaa caagagaaag aaaaccatca gataaagaca 575881 gcggcagcga tggcggtgtt acgaaaggcg gcacgtcata cagtgggagc cggggcagtt 575941 tttaaatgta agaaatagag aaagggagag gcgtaatgtc gtttttcaga aatcaattag 576001 cgaatgtagt agagtgggaa gaatttagag atgatatgat tttttataaa tggaacaatc 576061 gtgaaatcaa aaaagggagc cgtttaatca ttcgtcccgg acaggatgct gtctttttga 576121 acaatgggcg ggttgaagga gtctttcaag atgatggcga ttatgatatt gaatcagaaa 576181 ttattccatt cctttcaacg ttaaagggct ttaagtttgg ctttaacagc ggcatgcgag 576241 ctgaggtgct gtttgtcaat acgaaggaat ttaccgtaag atggggaaca aaacaggcga 576301 taaatattcc ggcagcggga atgccaggcg ggatgcccat tcgcgcaaac ggcacattta 576361 atttcaaggt gcaggactat atcagcctga ttgataaaat cgctggcgtg aaagatcaat 576421 attttgtaga ggatattaaa acccgtatca tttctattct ggatcagctt ctcatgaagt 576481 ggatcacaag agaagggaaa gatatgttta atcttcaagc aaacgctttt gatattgcca 576541 agggaattca agaggactta gatatgcaat taataagcga cgggatgacg gtcactggtt 576601 ttcaaatcat gagctttaat tatcctcaag aggttcaaga tatgattaca aagaacgctt 576661 cctacggtat ggttggggat gtgaacagat accagcaaat atcaatgacg gatggaatgg 576721 catccggaaa gatgagcgga agcggagcgg cttcggatat ggctggaatg atgatgggaa 576781 tgaatatggc caatcagatg atgaaccaaa tgaatcagaa tcagcaggca cagtcatcag 576841 gcccacagtc aactggcagc ggaagcaaac cgaatttctg tccaaactgc ggaacaaaaa 576901 cgggcgaagc caatttttgt ccgaattgcg gccagaagct tgtataagaa tcatacagtg 576961 aaaagtccgg agtgatcagc actcgggact tttttattta ggagaataag cattacctat 577021 tgcttgctcc tgaacaggcc attttcgagc ccccgcttgg ataattccca gcagcaattg 577081 acgacgttcc tttattgaat tgacggcaat ttgaaatgtt tgctttgata aagccggtat 577141 gcctgattgt tgaagctttg agatgtctgg ttctggcggc gcttgttctg caggatggat 577201 ataggcagta tgaacggtat ccagatagtt tttgatactt gagcgcgctt ctttgatatg 577261 aagctgattc ggctgatatt gttcaggaat tccgtatttg aaaatggtta gagcctcatc 577321 caatacagca acagctataa tggatgattc ctgatgctgc gtgctgtggt aaaaatgaag 577381 gatggggaag gcgttatgct gagcggtcag ctttcccagt tctgatgagg cagcgacaag 577441 aagaaaatca atgtcgtgaa aatctttgcc attccatgca ttatggacga tttcagttcc 577501 gtcatgccct agacttaata cactttgggc aaaggagcgt ttttgattaa ccgcactcaa 577561 gacggaaatc aaatacgtga cagaaaatgt gatggtaagc agtccttgag ctgtttcaat 577621 aatcgtgaca agcttccata ggcctccgtt cggagcgagg tcgccatttc ctaatgtaaa 577681 catgacatag ccggaaaaat aaattcggtc tgaccaggaa gccggttctt ttgattgagt 577741 ttccataagt gagtgagggt cactcgagta aatcaaaacc cacccgctcc aaaatagact 577801 gatccatatc actaacgtca ggcataacag cagaggacca gccatactta gaacctttgc 577861 gtggtcaccg ctgattttgc ggcagccctt ccacagccag gcagacaggc atcttgtgat 577921 cgggccggca ccgctctcta accataacgt ggtccataaa aaatcaatca tccccgctgt 577981 caataataaa aggcctgcaa tgatataacc ctcattcatt ttggttgcct cccttaagtc 578041 agccttcttt tattttcttc tctatttcct tttatcctga gtctgaaaca attgaacgaa 578101 tgtttgattt tacagagaaa aataggtggg agttacccaa cacttactca tttttcaata 578161 tgaacagaaa atcacaagat ttttgacttg attcacacat tttcatgaag aaaaacgttc 578221 attttcccct tgaattggtg attttccttt tatagagtaa aaaattttca gaaatttata 578281 ttgactgaaa gcgtttttat aattatgata atatcagata taacaaaaat gtcactataa 578341 catcactaca attgaactat taagtgacta ataaatacca aatgaacgag gttatgcaca 578401 aagaaatgac cattgttctt ttaacgagaa atgaaatcgc ttccataggg attgacatgc 578461 taagaagaag ggaaggttat gaggttattg gataaaaaca tgaacaacta ttttctgaag 578521 cctgcttacg aaatgtgagg aaggcagcag ccctggaata agtttttgac atacgcattt 578581 tgaaaaagac tgggggaaac agtatgaata aacaaggaaa tcaaatgtca tttttacgta 578641 caattatttt agtctccact ttcggcgggc ttctttttgg ctatgatacc ggtgtgctca 578701 atggagcttt gccgtatatg ggagagccgg atcagcttaa tctcaatgcc ttcacagaag 578761 gccttgtcac cagttcactt ctttttggag cggcactggg tgctgtgttt ggcggcagga 578821 tgtctgattt taacggccgc cgcaaaaata ttttgttcct cgctgttata ttttttattt 578881 caacgattgg gtgtacgttt gcaccaaatg ttacggtcat gattatttcc cgttttgtgc 578941 tcggtattgc ggttgggggt gcatccgtaa cggtgcctgc ctatttagca gagatgtctc 579001 ctgtggaaag caggggacgg atggtgacgc agaacgaatt gatgattgta tcaggacagc 579061 ttttggcctt tgtttttaat gcgatccttg gaacaacaat gggagacaac tcccatgtgt 579121 ggaggtttat gctggtcatt gcgtcacttc cagccttgtt cctgtttttc ggcatgatca 579181 gaatgcccga gagtccccgt tggcttgttt ctaaaggaag aaaagaagat gctttgcgtg 579241 tattgaaaaa aatcagggac gaaaaacggg cagcagctga gctgcaagaa attgaattcg 579301 ctttcaaaaa agaagaccag cttgaaaaag cgacatttaa agatctttca gtcccatggg 579361 tgcgccgtat tgtgtttatt ggattaggga ttgcgattgt acagcaaatt acaggtgtga 579421 attcgattat gtattatggg actgaaattc taagaaattc cggtttccaa acggaagccg 579481 ctttaatcgg aaatattgcg aatggcgtga tttcggtatt ggcaacattc gtcggaatct 579541 ggctgctggg aagagtgggg cgccggccga tgctgatgac aggcttgatc ggtacgacaa 579601 cagcattatt gctaatcggg atattctcac ttgtacttga aggatcaccg gcacttccgt 579661 atgtagtcct gtcattaacg gtcacatttc ttgcttttca gcagggcgcc atttcaccag 579721 tgacttggct gatgctatct gaaattttcc cgcttcgcct tcgcggactg ggaatgggtg 579781 ttacggtatt ctgtctgtgg atggtgaatt ttgcagtcag tttcacgttt ccgatattgc 579841 tggcagctat cgggctgtcc acaacgttct ttatcttcgt tggattagga atttgctctg 579901 tcttgtttgt gaagaggttt ttgccggaaa cgaaagggct ttcgcttgag cagctggagg 579961 aaaacttccg cgcttatgat cacagcgggg caaagaagga ttctggggct gaagtgattg 580021 gataatttaa aaaagaatcc gcacccgagt gcggattctt tttggtttca aattagttag 580081 gtctaacaag gattttgact tggcttttct ctttaataag agccccgaag ccttcctcga 580141 tcaaatcatc tagtacgatt tttttcgtta cgagtttgtc ggctgagaaa tagccttctt 580201 tcattaatga caatacagcc gggaagatgt cgcggtatcc gataattcct tttactgtac 580261 gttctttgat tacgatatcg ttcggatgga tttcagcacc tttttcccaa atgctgacga 580321 tgacggtttc accggcaatt gtagtggact ggatggcttg tcgtaacacc actgggacac 580381 cagtgacttc gaatgctacg tcaacaccgc ctcctgtacg ttctgcaatc tcagcgacta 580441 catcgtctgt tttagacgga tcaacgatga tcgcgccaag ctcctcagct ttttgctggc 580501 gttcaggaga aagctcaaca gcgtaaatat cagttgcacc ggcagccttc agcgcttcaa 580561 tgacaagaag tccgatcggg ccgcagccga atacagccgc tttgtcgcct gctttgagtt 580621 tgcttgagcg gacagcgtat agagcaactg cagaaggttc aacgagcgcg ccttgttcat 580681 atgataattc atcaggaagt ttgaacaaaa gctcttcatc cacagagacg tattcagaga 580741 aaccgccgcc tccgccggct aagccgagga atcccatttg ttcatcaagg ttgtaggcgc 580801 cttggtggcc gtgtgtagca aaaatcggct cgactacaac gcggtctcca actttataat 580861 tttcaacgcc ttctccgact tcgacaactt caccggagaa ttcatgcccc attgtgacag 580921 gtgccgtttc atttgttaat gggtgcggtt tgtcaaccgg aataaagatc gggccgccca 580981 gatattcgtg taaatcactt ccgcagatgc cgcaccattt gactttgatc tttacttttc 581041 ccggctccgt ttttggctct tcgatatgtt caatacggat atccttttgg ttatgccatc 581101 ttgctgcctt catggattac cactcctata acttttgatg tgagtaattc cgcaccggtc 581161 aatatgaact gttcacaaaa tcgccatttt taaaaccaaa aaagaaatga aatttttata 581221 taatataatc tacgtttttt tgaaaaaaag aaactttaaa gaaaaaaggg tctcgcacac 581281 tcttttttct ttatatgaga gtatcaatcg tttacatagc tatgaatttg gtttgaacaa 581341 tacggtaatg gttcgttcat attgaatgcg acaactactc tatcaataat tataactcta 581401 atactgctat tataatagga taatcttcca tggtttattt tagcagaggt aacttttttg 581461 actttgtaac attactgtaa ggatattgaa ataaaaaata gctggttgat cgtgtataat 581521 cttcctagat gttaacaaac agggggacga aatgttgaag aaagtcattt tagccgcttt 581581 tatcttagta ggaagtactt tgggagcttt tagtttttca tcagatgcca gtgcgaaaca 581641 tgtgaacgga aatattactt ggtataatgg agtcgggaaa aaaggctctt caggtaagaa 581701 acttggacat tgggattgtg cgaccaaaat cggatttgat gttcctagaa acgggacaaa 581761 aatcagagct tatgcaaaag cgaagcctaa aaaggtgatt acggtttata aaaatgatgt 581821 tggcagaatg cctaatgcag tgctggatgt tagccctaaa gcgtttaaag cgcttggata 581881 cccattaagc aaaggtaaag tagcggggca ttacagctat taatgtacat atataatctg 581941 gaaagcaaga agtcacattc ttgctttttc tattggtgga gataaaagat gaaaaaaaga 582001 atcatattat tattagcagt gataatagcg gcagctgccg cgggggttgc gttttatgtt 582061 gcaaaggata aaggccatga gaaggctgct gatgtttcag tcaataccga aagcggtgat 582121 gagctgctgg tttcaattac agatacggat ctgctgacaa agtattatga aaatgacaag 582181 gtgatccatg aggagaagct gaccagctat ccggcatttg ccttggatca aaaacagcag 582241 gtgctctatt atacgggcaa taatgaacag aatgaaatga ggctttttaa attggatctg 582301 aagtctcata aaaaaacgat gctttataaa ggcgcggaga gtgcggacag tttattttta 582361 tcaaaggacc gttcaaccat ctatttccgc ttaggaaaag cggacgaaag caattttcga 582421 atcgccgctt ttgatctgaa gacgaaaaag tataaaaatc tttatcctgc cgctaatgat 582481 caggatgaca ccgtcagcag cttcttttat aaccaaaaaa acgattcatt tgcattgctt 582541 cattattctg tagaagaaga ctacaagaaa acagatgaag caaacgaaaa gggcatcgac 582601 cctgaaccga caacgattca ttttgcggaa ggccgccaaa ataaatttaa tgagctgaaa 582661 agcctgaacc aatttatcag cgatattgct gtttctgatg atgataaacg tattttattc 582721 acatcatata cgcaaaaagg aacggagcaa accgcttcta ttcaaatgct caatgcggat 582781 acgaaaaaat atgaaagcat catctcaaat caaaaatcat ttaagctgtt aattgacgca 582841 cagcctcagt tttctaagga tgggaagaac atttattttc ttgccgaagc caagggggct 582901 aaaaagctga aggacgaaac agggcgtgaa gctaaggtgc ggacgattta ttcctatagc 582961 cttgagaata agaccttcaa aaaagtatgg gaaaatccga acggcatcat caacagcttt 583021 tttgtgatta actaataaaa accactcggc atgagctgag tggctttttt aatggatgag 583081 gtgcagggct aatgatccga gccatttaaa gatatgaatc agaggtaccg acaaaaacag 583141 aagttcaaca tatgagttca ttgcaacatt cagctttttg aacgcagctc tttttttcaa 583201 gtctttttgc tgctggtttg agatcacgtt atcactcctc ttatatccat attataccat 583261 taaaacagac aaaaaagccc taaacgttta cagttttggg cttctttctt cgtatttggc 583321 ctcttgcaat gagaggcttt tattctgaaa tatagaattt tgtctccgtt cggggtttgt 583381 ttgcttgcgg gagactgcat ttgttatagg gaagaactag cttgttttcg tttggctgtt 583441 gttttggaga ttcactaatg aacggatgcc gtcgaccatt ttacttccgc acaaagggca 583501 caatggcgta tcactgctgg cgaagttttt tcgggtccag ccattacagt cttcttttgt 583561 gcattcccaa gtactcacat cttcctttgg cagcggttct tgatttcgtt tgttatagta 583621 agacataaag tcacttcttc cctcatgtat tttactgcac atttcctatt gtctcatact 583681 tttccctaat ctcctaattc ctttttcttt atgactttcc aataacccca tctaaaaagg 583741 agaggagtgt gctgttaaaa gcatctggct cttctaaaaa cgggcaatgg ctgcttttag 583801 gaaaggtaac gagtgtcgcg tttggaatat tgctgcgcaa gtgttcccca gctgctgtag 583861 agaaaaattt cttgtcttcc ccgaagcaca gcaatgccgg cacattgatg ttttggaggg 583921 tgccccggta atcagcggcc gtttggttaa ataaaatcgt gctagaaatg gcagccggct 583981 gtttgaggat ttctgccagc atccattctg tttcggtctc ggcaggcggt tctgcgaaca 584041 tattctggat gaagctttcg tagaaaggca gcgggtcagt ttgaatggcg tgcatcgctg 584101 tttttaagcc gtcaaaatca aatggaccat gttcccagcc ctcccattga tagtccgaag 584161 cggattgatc gatgatcaca gcggcttgaa tgttatcatt cccaaactga ttgagataat 584221 cccatacgac aaaagcaccc attgaccagc cggcaagaac gacatgatca agctccattg 584281 catttagaaa ttcccttatg tcacgggcat attgggaaat ggtgtggccg tgaagcactt 584341 tgtcagattc gccgtgtcct ctaagatcaa gacgaataca ttgataattg gcagaaagca 584401 ccgaaaattg tttgtggaaa aattgtccgc tcatcagcac cccatgtata aacaggatcg 584461 gcgtcccgct cccgtgtgtt tcatagtaaa ggcgtgtctg atcttctaat atgatgtatg 584521 gcatgtttct cctcctttag tttccatcat gagtatggct ggctgctgtt gagctgatga 584581 tggcagctgt cgcggctgcc tgctgcgctt gaatgactgt ttcgatagcg gtgtatagtc 584641 ctgattccat cagcagattt ttctccatat gctcactgag atagaggctg acagcaattt 584701 taaagttcat ttccttttgc catttaaaag ctttttcctg gtttaattcg tcagtgatgc 584761 acaaaacggt tttgatatct ggctcttcca gaaatgtgag gagagcaagg tctggataat 584821 gataatcctt tgtttttttg acagattcag tgatcgattg atatatctgt ttgcaagcgg 584881 aaacaagcat ttcgggctct ttttcacttt gcaaggccag aatatggctg acctgatgta 584941 agtactgtcc ttttttaaag ccgttggctg ccagcagttg atagcatgtt tccgccttct 585001 gtagcgcctg caaacctttt ccgttttctc caagcagtac ggcaagcgga acattctgag 585061 ttgaagtgag gaaataatga tttttcttca tctgctgata aacagctagc cccatgttca 585121 tctgttcttt ttggtttgtc gtttcagatt tgccggtgag caagatcaga gcggaaaggt 585181 atgtgaacat atcccgctta taccctagct tcaccatttc attgtataca tcgatgaaag 585241 tctgaaatgt ttgttttgcc tcatgctgaa aatgaatgtc cagaatagat gcaacagtaa 585301 agcggtggtg tgaattgagt gttgagaagc tgccgatgtt tgatttgata tagctgctca 585361 aatcataaaa gcgctgaaaa tcaaactctc ttttattcac aatatatgca gaagaaatga 585421 gcattaatat ctgatcgtgt gaaactttcc attttaattt tgtttttaat tcagcataaa 585481 tggaaatgta atgctttgtt ttttcatgta gatcgtgtgt gagcataaaa agcagctcct 585541 tttgttgttt ttacgtaata cgataaatag ggccaaaggt ttcataaaga aaaaacttgc 585601 ctgctagagg caagtttgtc gggttattta tggggatcag ttatatccat cggtctcatc 585661 atgtcatagt cttcatgctc tagaatatgg caatgccata cgtatcgtcc gctgtacgga 585721 ccgaatgtcg ccgcgattct caggacttca cctgcatgcg cttgaatggt gtctttccag 585781 cccttttcac ttggcggcgg cgggacagcc ggaccggtat aggacaattc cccgctttct 585841 tgataacggg cgatatcaaa cggccgccgg tctaatacac ggaaggagac tagatgcagg 585901 tggatcggat gtgttccgcg tgtcgggttg ataatggacc atatttcagt tgtgccgact 585961 tttggtgttt ctgtgacggg atcgtgccag cgtttgttat taagcagaag gacgggtctg 586021 ccgtattcgt cctgggtgcc tgccagtttt aacgttctga tgttttgtat tctttcatgc 586081 tgtaccgaag ggtatgaggc gaggtacttc ggctttctgc tttcgtcttt ttgtgccaat 586141 ggttttgtga ctctgaattg catgatattc gcatctgttt caggattgac gtcaccgccg 586201 cagcccgcgc tgtttgccaa aatgatcgat tctccttcat atgctgtgaa gtcaatgatg 586261 atatcgtaac gttcagcagg cgcaaggctg aaagaattca gtttaacaga tcgcggcagg 586321 agccctccat ctgaaccaat ctgaataaaa tctccgccat tatcgagtga caggttatag 586381 gttcttgtat tggaggcgtt gatgacacgg aatcggtatt tccttggctc gacttccaag 586441 tatggccata ccttcccgtt gacgagtatg gtttctccgc aaaaagccgg aacgattgaa 586501 ggattaggca gtgacggaga agggttttcc ggtgcgctcg gataaaacaa agaaccatcc 586561 tcattgatcg tgcggtctgt gataagaagc ggcacatcgt attcgtctga aggcagtttt 586621 aagcgttttt cctttgggtc atgaatgata tatgcaccga caagtccggc atagacattt 586681 agcctggtga gcgccatggc gtgatcgtga taccacaata tagccccgcg ctgctggttt 586741 ggataatgat aaacctctct tttgaaataa ggtcctgttt gttcaaagtc tttggaaaac 586801 caagcctccg gatacccgtc actatcatct ggcgtgacgc cgccgtgtaa atgaacaaca 586861 gtctttacct cgggctcttc atgctggctg tcactgtgat gaatggtgtg atcaatcgga 586921 aggaaatgcg tggaaggaag gttattcatc cattttacat atacgttttc atttctttta 586981 acctcaatgg tcggtcccgg aaataagccg ttgtagcccc acaggcgggt tggagggaga 587041 tcgcgatgga gctgatgagt gcattcctcc atggtgactt cgtagtatgt tttttctttt 587101 gattgctgta ctggctttag tgtatctggg attgggagag catccacaaa tttttcaagt 587161 gtcattttca tctgtcctta tctaaatttt ccaaattggt actatagtta atgacaataa 587221 ggacgtgatg gttacaaaaa atcttcgtgc tgcagcccgc ccgaagaaga aaataacaaa 587281 atcctaaacg gcaggccgtt taggatttga tcagcattaa ggcaggatat cgggttgctg 587341 ctgtgtgact gggttggcag ccgctttctc gctcaccttg cgttttctga acacaaggta 587401 agaaatcaga acgattcccg tgatgacgcc tgtcagcagc agctcgtctc tcatggaatc 587461 aataaacgcc atggacacta aaattccgca aatggcgatg atggtcaagt aggttaggaa 587521 agggaagagc cacattttga tcttcaatgc ttctgggttt gttttttcga gttttttccg 587581 cattttcagc tgggaaacgg cgatgacaag atagacgagt aaagcgattg cgcctgatga 587641 gttgactaag aataaaaaga cggtatccgg tgaaaaatag ttcattacga ccgcgatata 587701 agagaaaaat gtcccggcca caatggcttg tacgggaacg ccttttttgc tcaatttcat 587761 aaaacggcgc ggcgcttcat ttctttctgc aagtgaatac agcattctgg atgtggtata 587821 caaacctgaa ttcaggcaag agagtacggc tgtgaggacg ataaagttca taatctgtgc 587881 ggctgcgggc actcctatat gctcaagtac agcgacgaaa gggctttcta aaatatttgc 587941 tgaattccat ggcaacagcg ccacgacaat ggcgattgag cccacgtaaa agacgatgat 588001 gcgccataca acggatctgg tggcttttgt cacagattcg atcgggttgg atgtttcccc 588061 tgctgcaatg gcaacgattt cagttcccat aaaagagaag atgacaacga caatgccgag 588121 caatacggag ctgatgccct ccgggaaaaa tccgcctttg cctgtaagat tcgaaaaacc 588181 gactggctca ctgcccggtg caaagccaaa aataaaggca aaaccaacga ttagaaaagc 588241 aatgatagtc acaactttaa tgagggagaa ccaatattca aactcaccga aagacttaac 588301 ggagtagacg tttgtcaggg tgagcacaat ggtcaagatc aaacttgtca gccacagcgg 588361 aatatcatgg aaccagtatt gaataatgcc agcaccggca atggcttcga tcgctatgac 588421 gatcacccag aaaaaccagt acagccagcc gattgtaaat cctgcccacg gtccgatggc 588481 gtcgtgagcg tattgagaaa acgatccgct cgtcgggttt acggcagaca tctcaccgag 588541 cattctcata ataaaaatca ccaataatcc ggctaacgcg taagaaacaa cggcacccgg 588601 accggtcgag tgaatcactg aaccgctgcc tacaaatagg ccggctccga ttacaccggc 588661 aatcgaaatc attgtcatat ggcgggtctt taattccttt tttaatcctg attgagactg 588721 gttcataagt tacctccttt taaaatgcaa tcattactga atattatgat aattgaaact 588781 ctatcataaa tatacagttt gtcgaaaatt cgtgtaagaa aatataccag cttatttcaa 588841 atttgtagtg ttttgtttgc gctttcagcg aatgtgtgga aaaaatgttt cgttttttat 588901 tcgctgtgtg attttgcgta atatttacaa ttcgatagaa tgcgagaagc actggtgtcc 588961 ttgggtttga tgggattttt ggcggagcaa ataaattgga tgagagaaaa agtgttcctt 589021 cgtcactatt tttctgtggc gggtgaatca tgtttctgta gacccactgc ggatcagctt 589081 tgtaagataa taataggaaa atgtgagcga gaggaggttt tgtatggaga gatatgatga 589141 actgaaaaag ggagaatccg gagcgctggt cagcattgcc gcgtatctag ttctttccgc 589201 aattaaactg atcatcggtt atctttttca ctcggaagca cttacggcag acgggttaaa 589261 taacacaact gacattattg cttctgttgc tgtgctgatt ggcctgcgca tctctcaaaa 589321 gcctcctgac gaagatcatc catacggcca ctttcgagcg gaaacgattg catcgcttat 589381 cgcatcgttt attatgatgg ttgtcggact gcaagtgctg ttcagcgccg gagaatctat 589441 tttttctgct aaacaagaga cgccagatat gattgcggct tggacggcag cgggcggggc 589501 agtcctgatg ctgatcgttt accggtacaa taaaaggctg gccaaaaagg tgaagagcca 589561 ggcgctcctt gctgcggctg ctgataataa atcagacgca ttcgtcagta tcggcacatt 589621 tatcggcatt gtggctgctc aattccatct tgcttggatt gatacggtca ctgcgtttgt 589681 gatcggtctg cttatttgca agaccgcatg ggatatcttt aaagagtcat ctcactcttt 589741 gacagatgga ttcgacataa aggacatttc cgcttataaa cagacaatcg aaaaaatctc 589801 cggtgtgagc cgtttaaaag acataaaagc aagatacttg ggcagtacgg ttcatgttga 589861 tgtggtggtt gaggtatcgg cagatttaaa tattacggaa agccacgata tagccaatga 589921 aattgagcgg agaatgaagg aggagcatgc gattgattat tcgcatgttc atatggagcc 589981 tttagaacaa aaataatgga gcttcctgtc acaggaagct tcagcgtgtc gacaaaccct 590041 cgcattcgtt gtcaggtctg cgcttcggtg ctcacgaatt agaacattcg ctccgctcct 590101 atgctcgtcc ttcctagact tcaagggttt tcaatcacgc tgaaaagatg acaaaaccct 590161 aaaatgaaag ccattttagg attttgtcaa caatctggag cttcctgcca caggaagctt 590221 ttttgtgtgt tttggccagc tttattggta acaatttgct agaatcgttt ttttatacag 590281 attgcttttt gtggtaaagt taggttacat tatgatgaat tttgtagatg actaggagga 590341 aaataatggc atatcaagaa gacctgcatc ctttgctggg gaaagcagtt gaacatatta 590401 atagagtaat ggttggaaaa cgagacatcg ccatactcag cttagcagcc cttcttgcca 590461 aagggcatgt gctgcttgag gatgtacccg gagtcggaaa aacgatgatg gtccgcgcgc 590521 tggcaaagtc aatcggcgcc gatttcaaaa gaatccaatt cactccggat ttgctgccat 590581 ctgatgtaac aggggtatct atctataatg cgaaaacgat ggaatttgaa tatcgtcccg 590641 gcccaattat gggaaatatc gtgctggcag atgaaatcaa ccgtacctct ccgaagacac 590701 agtcggcttt gctcgaagcg atggaagagg ggagcgtcac ggtagatggc catacgatgc 590761 agcttgccga tccgtttttt gtgatggcaa cgcaaaaccc ggtcgaatat gaagggacct 590821 atcctttgcc ggaagctcag cttgaccgtt ttttattcaa acttcggatg ggttatccgt 590881 cctttaatga agagcttgac gtcttatctc ttcaggaaaa aagccatccg attgagacgc 590941 ttgagccggt tattgcaaaa gaagacttca tctttttaca gagggaagtg caaaatgtcc 591001 gtgctgatga cagcattaag gaatatatcg ttgaaattgt gcagaaaacg agacagcatc 591061 cttctgttca attaggcgtc agtccgcgcg gctcaatcgc cctcatgaaa gcggcacagg 591121 catacgcgct gctgcatcat cgcgactatg tcataccgga tgatattcaa tatttagctc 591181 ctttcacgct gccgcaccgg atgatgcttc atcctgaggc aaaatttgaa gggattcagg 591241 cagaagcgat cgtaagggag atcatgtcag ctgtgaaggt gccggttcaa aggtcggcgg 591301 tccgctgatg aataagaaat ggcaatggct cgtatatggt tggaagctga ttatattaac 591361 tttattgacg gctgctgttt tttcttatgc gatgtttcag ggcggctttg tcagctggtt 591421 tttgttttac gcgtttctcc cttttgtctt gtatgccggg ctgttggcct tgtatccgct 591481 ccgttctttt caggcttcaa ggcaaatgga taaaacacaa ttgcatgcgg gggacaggct 591541 gggcgtaacg gttacgctga gaagaaagct gccatttccg ctgatgtata tggtgattga 591601 agattgcctg ccagaaggta tcgagtcatt aaatcgagac ggagccgcgg ccaaacggct 591661 cgtttttcct tggtttaaac ggagcatgac gatgtcgtat gaattagctc gggtaccgcg 591721 cggagagcat cactttcatt ctgtcagggt gcgaaccggg gatgttcttg gcttgattga 591781 aaaaacagca ttttttgagc tggatgatac cttgtttgtt tatccattct atcagcgttt 591841 ttcctatcag gtgaatgaga ggcatcagga agacggtgta agcggttctt ctcctattca 591901 tcagcaccat tcctcagtcg cagcaagtgt gcggaattat cagccgggag accggtttgc 591961 tgcgttagat tggaagacat ctgcacggcg gagccagctg atgacgaagg aatttgagcc 592021 ttctcgcagc aaaaatctgt ttctgctgat ggaccgtttt tcctcagacg cattcgaaga 592081 ggtcgtttca gtgacagctt cgattcttca ttctgtttta aaaaacggcg cgggtgctgg 592141 tctggcttcc atcgggaagg aaaaaaacat tttccctatt caggaagggg atcagcattt 592201 taagcacatg cttcggcatt tagccatcgc tcattgtgat gcggcagacc cgataagccg 592261 atatgcacgg gaagagctgg gaaagccatc tgttcgccaa gctgatcaag ttgttgtcac 592321 gggacagtta acggaagata tgctgcacct cgcagaaata ggaggcggcc gggttacggt 592381 gatactggca aaagagaaag atgctgagct ctctcaagct gaaaatgtca tgattgaacg 592441 catgatgaaa cgccaaatca gagttcggat catgaggggc gggcgagttt cgcgtgttgt 592501 ttagaaagag aggtgactgg ttcacatgcc gcacgatgat cacaagggaa gccgtttgag 592561 cttgctgtta ttttattttc tggctttttt attgctgtgg gagtggctta ggccgcttga 592621 cagttttact gaaacgaaac atacaggctt ttttagtgtc tttatcggct tgacgtttct 592681 gctgactttt ttcaggatga ggtggtttgt caccgttcct ttttgtgtca tatttacatt 592741 gatctcgata cacatcctgt tttatcaagg atctatattc gacttgagct gggtcagctc 592801 ttttttgcag gatgtctatc tgaatatcac gctgattcaa tcagggcaat ggaatgacat 592861 gattccttca tttcggaccc tgctgttttt tgtgctgctg tggctgctgg tctatctcct 592921 gcattattgg gtgatttacc agagaagaat tttgtttttc tttttgatga cagtagcgta 592981 tattacgatt cttgatacct ttacgccata tgatgccact tttgccgtaa tccgtatcgt 593041 gctgatcggc ttctttatgc tgggcctttt atacttggaa cgcattaagc tgatggaaag 593101 aatcacactg ccaaaaacat ctgtcctgaa atggtttctt cctttatctg tattggtttt 593161 ggctgcaacg ggattcggac tcgccgctcc aaaatcagag ccggcttggc ctgatccggt 593221 gccttttctt aaaaaaatca ctcatcaaga ccgcgtgtct gcaggggaaa gcaaaatcgg 593281 atacgggaat catgatgaat cactcggcgg cccgttccag caggatgcta cacctgtttt 593341 tacatggcag ggaaaagagc gtacgtattt ccgtgtggaa acgaaggaca cgtataccgg 593401 aaaaggctgg attgaaacag acacaggcat gtcgtatcag cttagcaatg gaaaagttga 593461 aaatctgtgg tttgaccata aggttgcgac agagcgccgc accgtccgtg taaaagtcga 593521 taagcactac gggtataacc atctgatgta tccgattggt gcggaaacca ttcagccaaa 593581 gcaggctgtc tcacttgaaa tgaacggcaa cacggagcaa atttctccga tcagtgaaca 593641 agccggtgaa atcagaaata tggggaatta tacagtaacg tacaattccc cggtctataa 593701 gctggatgaa ctgagaaagg taaaagtgag aaaaaacagt gaggagtaca cattcagcga 593761 tcgctacatg cagcttccag attcactgcc agagcgggtg agaacccttg cgatcaaact 593821 gactcaggat cacgacaata tgtttgataa ggtgaaagcg gttgaggact atttagggtc 593881 aaatgcgttc acatatgaaa cagaaaacgt gaccattccg aagaatgatg aagattatgt 593941 cgatcaattt ctctttgaaa cgaaaatggg ttattgtgat aacttttctt ccgccatggt 594001 ggtgctcttg cgctcggccg gcattccggc ccgctgggta aagggttata cgtccggcga 594061 atacaaagaa gcagggaaca aaaatggcag catttacgaa gtgacaaata acaatgccca 594121 ttcctgggta gaggtgtatt tcccggaaca gggctgggtt acatttgagc cgactaaagg 594181 gtttacaaat ccggctcaat ttacatcttc tgacacaaaa gactctggca gcgatagcag 594241 cagctcgccg aagaaagcaa aagagaaaca gaaagaagag aaaaaacagc cgcaaaaaga 594301 ggaaaaacaa aaggaaaagc gggagccagc tgtttctaaa aagccgtccg cttcgcatac 594361 taatgccggt gcgggcttgt atgcagcgct tgcggttctt gcagtcctcc tggtggcagc 594421 tgtattgctg tatgttttcc gctcgttatg gattcctgtt ttcgccgtga ggaaattgaa 594481 gcggcgcagt gatcagcacg cgttttttga ggcatatggc gcgctgctga aacaactgaa 594541 gagaaaagga ctgccgaaac gagacagtga aacgctgcgt gattatgcaa aacgaattga 594601 tgaaaaatac gacatagaag acatgtcaaa gctgacatta agctatgaaa gggcgcttta 594661 cagaaatgaa gattcttcgg cgctatggaa tgattcgaga gagttatggg aaaatttaat 594721 taaaagaaga tggtcttgac cgcttatcga cgtgttgtta gaattagtga atattatcgg 594781 agtctgggag cgagttggcc tgactccggc aaacggcctt gccaaagagg gcggagcgag 594841 cttcatatct gtcctcgttt ttttctgtgt caaaaaactt agaggagatt aggtgacaac 594901 catgacaaag ttagtgaatg aaatgattct tgtccttgat ttcggcagtc agtataacca 594961 gctgattaca cgccgtatcc gtgaattcgg tgtttacagc gagctgcatc cacatacatt 595021 gacggctgaa gaaattaaaa aaatgaatcc aaaaggaatt attttatccg gcggtccaaa 595081 cagtgtgtat gatgaaaact ctttccgctg tgacgagaaa atcttcgagc ttgatattcc 595141 tgttttggga atttgctacg gcatgcagct gatgactcat taccttggcg gtaaagttga 595201 agcggcaagc cagcgtgaat acggaaaagc aaacatccgc atcgaaggca cacctgattt 595261 gttcagagat cttccgaatg aacaagtggt ttggatgagc cacggcgatt tggttgtaga 595321 agttcctgaa ggcttcactg ttgacgcgac aagccatcac tgcccgaact cagcaatgag 595381 caaagcggac aaaaaatggt atggcgttca gttccacccg gaagtgcgcc actctgaata 595441 cggcaatgat cttctgaaaa actttgtatt cggtgtttgc gaatgcgaag gcgaatggtc 595501 aatggagaac tttatcgaaa tcgaaatgca aaaaatccgt gaaacggtcg gagacaaaca 595561 ggttctttgc gcgctaagcg gcggcgttga ttcctctgtt gttgctgttt tgattcataa 595621 agcgatcggc gaccagctga cttgtatctt tgtagaccat ggtcttctcc gtaaaggcga 595681 agctgagggt gttatgaaaa cattcagcga aggctttaac atgaatgtga ttaaagtaga 595741 cgcaaaagat cgattcttaa acaaactaaa aggcgtttct gatcctgagc aaaaacgcaa 595801 aatcatcggt aatgaattca tttacgtgtt tgatgatgaa gcggacaagc tcaaaggcat 595861 cgactacctt gcacaaggta cgctttacac agatatcatc gagagcggta cagcaacggc 595921 gcaaacgatc aaatctcacc acaatgtcgg cggacttcct gaagacatgc agtttgagct 595981 gatcgagccg ttaaatacgc tcttcaaaga cgaagtgcgc gcgcttggca cagagctcgg 596041 cattccggat gaaatcgtat ggcgtcagcc gttcccagga ccgggactcg gaatccgcgt 596101 tcttggcgaa gtaacagaag aaaaacttga aatcgttcgt gaatcagatg caatcttgcg 596161 tgaagaaatt gcaaatcacg gcttagagcg tgatatctgg caatacttca ctgttcttcc 596221 tgacatccgc agcgttggtg ttatgggtga cgcaagaaca tatgattaca caatcggaat 596281 ccgcgccgtt acatcaatcg acggcatgac atctgactgg gcgcgtatcc cgtgggatgt 596341 gcttgaagtc atttcgacac gtatcgtaaa cgaagtgaag cacattaacc gcgtggtgta 596401 tgatattaca agtaagccgc ctgcgacgat tgagtgggaa taagaatcaa ttaatggaaa 596461 ccatcttttt ggcaattttg ccgggaagat ggttttattt gtttattacg aacaaaatcc 596521 gattttgcgc gactattgtt cgctttttgt attgtttttt caaaatgaac ttggtacaat 596581 agacacagaa atcaaataag atgaattcgt ataatcgcgg gaatatggct cgcaagtctc 596641 taccaagcta ccgtaaatgg cttgactacg taaacatttc tttcgtttga tataaataaa 596701 acacggttat ttattcaaac tgaaatccgt ctgtagtcaa gcgtcccaaa atgtattggg 596761 acgtttttta tttggcgttt tcaggacaga ataaatagca aagagtgaag ggagtcaaat 596821 agcttgaaaa cgttttttca gtttgatgag ctgggcacca gctatcgcaa tgaaatcatt 596881 ggcggattaa cgactttttt atctatggca tatattttgt tcgtcaatcc gattacgctt 596941 gctttggaga gcgtgaaaga ttttccggag gcgctgagaa ttgaccaggg tgcggtcttt 597001 acggcgacag cgctggcgtc tgcagcaggc tgtatcttaa tgggattaat agcgagatat 597061 ccgattgcca tcgcgccggg tatggggctg aacgcgtttt ttgcgttttc tgttgtcctt 597121 ggtatgggta tttcatggca ggcagctttg tccggtgttt ttatttcagg tcttattttc 597181 gttgctcttt ctttaacagg ttttcgtgaa aaaatcatca acgccattcc gcctgagctg 597241 aaattggcag tcggtgcggg gatcggcctg tttattacat ttgttggatt acaaggttca 597301 ggaatcatta cagcgaatcc ttctacgctc gtcacgatcg gaaacattca cagcggtcct 597361 gtgctgttaa cgattttcgg tgtgattgtc acggttattt taatggtgct tcgcgtgaac 597421 gcaggcgtgt ttatcgggat gctattaaca gcggtagccg gcatgatttt cggtttggtt 597481 ccggttccga ctcaaattat cggcagtgtg ccaagccttg cgccgacttt cggacaagcg 597541 tggattcacc tcccggatat tttctctgta caaatgctga tcgttatttt aacattcttg 597601 tttgtcggat tttttgatac agctggtaca cttgttgctg tggcaacaca agctggttta 597661 atgaaggaaa acaaattgcc gcgtgcgggc cgtgcgcttt tagctgattc atcttctatt 597721 gtgatcggtg ccgtgcttgg tacgtctaca acaacttctt acgtggaatc aagctcaggt 597781 gtcgctgcgg gtgcccggtc aggatttgcc gcaattgtaa cagggattct ctttttactg 597841 gctacgtttt tctcgccgct cctatcagtc gttacgtcaa atgtaacagc gccggcgctt 597901 attattgttg gtgcattgat ggtggcgccg cttggcaaaa tcgcttggga taagttcgaa 597961 gtggccgttc ctgctttcct taccatgatc atgatgccgt taacgtacag catcgcgact 598021 ggtattgcca tcggatttat tttctatccg attacaatgg tgtgcaaagg aaaagcaaaa 598081 gaggttcatc caatcatgta cgggctgttt gtcgtattta tcctgtactt tatcttctta 598141 aaataaggaa tgaaaaacca gctgcactgg cagctggttt ttttgttgca aaagataaaa 598201 ccatttcata cgatataccg tcatgtagat gtgccgccat gctttactta aatggaaatg 598261 acttgactgt tcaggaaggc ttcggtacct tatataagtg ttttattttc ttgctgaatg 598321 gtattccgcc gtattttttt gataggagtt gctgacatga cggaagaaag aaaagaaacg 598381 tttgaagaag aaattaacca gagtgaaaga atagatgcag atgaagaacc gctatcgaga 598441 atgtccagaa aggcgagccg gcaaagcaag cagaagcaaa aacaaaagca gaaaccgcgc 598501 caggaacgcg gtgaatcaac tgttaaagac aagcttgcgt ctgtttgggc agccatcaac 598561 agatattgcg gttttgcgtt ctcgatttta aaatctccgg cgaaaactgt cgtaacggat 598621 ggtttttctc attataagta cggtctgatt tcaatgctta tattcagtat cattttttca 598681 attgggaatt ggtttcagtt aaaggcaagc tggaatcggc cgctcggttt cggagaacgc 598741 catcatgctt tctatgacgg gtttttagtt gttcttgtgt atttgctgat ctttttcgcg 598801 gtaatggtct ttgctatatg ggctgtctcc cgctatatga tgaagcagaa ggtgacgttc 598861 agagaagcgg ctgccgtatt gggttcattg cttgtacccg taattgctgt ttcaatcctt 598921 tggctgatct ttgcgatcgt aaatatccca atgctgacag tactgtttac ggtgctgatc 598981 ttgttttcca tcttttttat catcgcgctg tatgtacagc gtgtgtacca ggcggcacaa 599041 gatgcaccaa ttgattatat ctattgtgta tttgcagtag ttgcgatagc gctgctgttt 599101 acggcagtga cttggccgtt tatttctgaa tatattacgg cgtcgttgat tccgctttaa 599161 tgaaaaaacc ggctaatcct agccggtttt tttatgtcac actttttaca aatatatcta 599221 aaaaacatag ttgatttgta ggattaaccc gtgtatgatg gggaaaatgc tgaaaacgtc 599281 cagcgcaaaa acctttatgt ttaaggagga tgatggacat ggctgatgta cttcgccgag 599341 caattaacca aaagaagcaa tttttaaaaa ccaaattact gctctcggaa ttttatcaag 599401 gaagagggga acagcttgct gactacacgc tgagtgagct tgagaaagaa tacaagtccc 599461 ttcagaaaat gaaaaaagag atctgacaat agatataaag aggtgagtct gctgaaaagc 599521 gggctttttt gttttgattt tgaaaaggcg agaaagaggg taaactacta ctgttcaaca 599581 cataaaagcg tgtcgaaata ttttgcttaa gcttacgggc gaagctgatt gtaaacggct 599641 catttctcta gtagaatatg aatgctttgt gcaagctgaa gagtaggggg atgaataaaa 599701 tgatgcaaac catcttatca aatgggatag ccatggttct cataattctc attattaata 599761 ttgtctatgt gtcatttttt acgataagaa tgattttaac gctgaaagga cagcgttatt 599821 tagcggccgg catcagtacg attgaaatac tggtttatgt gacaggactg agtctggtgc 599881 tcgataactt agaccagatt caaaatgtga tcgcgtacgc gctcggttac ggtcttggcg 599941 taattgtcgg catgaaaata gaagaaaaat tggcgcttgg ctatattatg gtcaatgtga 600001 ttacgaagga gctcgatctt gatcttccga agcagctccg tgaaaaaggc tacggcgtga 600061 caaactgggt ggcaggcggg cttgaaggcg accgcacagc ccttcagatc ctgacgccga 600121 gaagatatga actccagcta tatgatacga ttaaaacact tgattcaaaa gcctttatta 600181 ttgcgtacga accaaaaaca atccacggcg gcttctgggt caaagcggtg aagaagagga 600241 gaattaaaga ataatggcaa agccgaagaa gaaaaagttt gaagtgacag agcagcaaac 600301 gattgatgcg gtgcttcagc aaatgaaaga agaaggatat ctgcctgtaa ggcgaatgga 600361 agagcctatt tttatggaaa aaaaggaaaa tgggtcaatt cagatcgttc cgtgcgggaa 600421 aaaaatcgta tttgaaggga aattgatcta aaacacgaac attagtagaa tgaatttttg 600481 tatcgttcga taatatcgtt gacattatcc atgtccgttg ttaagataaa catgaaatca 600541 aaacacgacc tcatataatc ttgggaatat ggcccataag tttctacccg gcaaccgtaa 600601 attgccggac tatgcaggaa agtgatcgat aaaactgaca tggatatatc gcagaagcga 600661 acgactgacg atacatgtac catgcccggt ttgtattgct tcctcataag tgcaatgcag 600721 agcgggtatt ttttattttc tgaaaacaaa agcattagaa ggtggggaac agaatgcagc 600781 cgctagtagg aatcatcatg ggaagcactt ccgattggga gacaatgaaa cacgcatgcg 600841 acatacttga cgaactcaat gttccgtacg aaaaaaaggt cgtttccgct caccggacgc 600901 ctgatttcat gtttgaatat gctgaaactg ctagagaaag aggcatcaag gtgattattg 600961 ccggtgccgg aggagcggcg catctgccag ggatgacggc tgcgaaaaca acactgccag 601021 tcattggagt tccggttcag tccaaggcgc tgaacggaat ggattcactt ctttccatcg 601081 tccaaatgcc tggaggcgtg cctgttgcga caacatccat cggcaaagcg ggtgctgtga 601141 acgcaggcct gttagcggcg caaattttgt cagcatttga cgaagacctt gcccgtaagc 601201 tggatgagag aagagaaaat acaaaacaga cagtgttaga aagcagtgat cagcttgtct 601261 aaacaaatca tctatccggg agctgtaatc ggcattatcg gcggcggcca gcttgggaaa 601321 atgatggctg tgtccgccaa acaaatgggg tataaagtcg cggtcgttga tccggtgaaa 601381 gattcgccgt gcgggcaggt tgcggatgtc gaaattaccg ctcattataa tgaccgtgaa 601441 gcgattcgaa aattggctga aatcagcgat atcatcacat atgagtttga aaacatcgac 601501 tatgatgcgc tgcattggct aaaagatcat gcgtatctcc cgcaaggaag tgagctgctg 601561 cttattaccc aaaaccgtga aacagagaaa aaagcaattc aatccgcggg ctgtgaagtc 601621 gcaccgtaca gcatcgtcaa aacaaagaat gaattgaaac aggcagtaca ggagctcagg 601681 cttccggcag tgctgaaaac atgccgcggc gggtacgacg gcaaaggcca atttgtgata 601741 aaagaagagg cgcaaatgga gcaggcagcc gctctgttag aacacggaac ttgcattctt 601801 gaaagctggg tttcttttaa aatggaactg tcggtgatcg tcgttagatc ggtaaacggt 601861 gaaatttcaa catttccgac agctgaaaac attcaccaca acaatattct tttccaaagc 601921 atcgtgcccg cacgggtaga gaaagggatt cagcagaagg ctgctgatct cgcagttaag 601981 cttgcagatg agcttaacct tgtcggaccg cttgctgttg agatgttcct gacagaggac 602041 ggagagcttt tggtcaatga actggcgcca agaccgcaca attcagggca ttatacgctg 602101 gacctttgcg agacgagcca gtttgagcag catatcagag cggtatgcgg gcttccgctt 602161 gggaagacag atttgctgaa gccgggcatg atggtgaatc ttctcggcga tgaagtgaag 602221 cttgttgagg aagacccgga gcttttaaaa gaggcaaagc tatatatata cggaaaacat 602281 gaaatcaaaa aaggccgcaa aatggggcat attacattta tgaagcagcc tgaagacgaa 602341 tggattcagg agatcacaaa taaatggatg aatagagacg gaggacaagc agaatgatcg 602401 aacgttattc aagacctgaa atgtccgcga tttggacgga tgaaaacaga tttcaagcat 602461 ggttagaggt tgaaattctt gcctgtgaag cgtgggcgga gcttggcgtc attccgaaag 602521 aagatgtaaa ggttatgcgc gaaaacgcgt catttgacat caaccgcatt ttagaaatcg 602581 aaaaggacac gcgccatgac gttgtcgctt ttacgcgcgc tgtatccgaa tcactgggcg 602641 aagaaagaaa atgggtgcat tacggcttaa cgtcaactga cgttgttgat acggctcttt 602701 cctacttatt aaaacaggca aacgatattt tgctcaagga tcttgagaga tttgttgaca 602761 ttataaaaga aaaagcgaaa gaacataaat acacagtcat gatggggcgc acacacggcg 602821 tacacgctga gcctacaaca ttcggcttaa aacttgcgct ttggcatgaa gaaatgaaac 602881 gtaatcttga gcgcttcaaa caagcgaaag caggcatcga ggttggaaag atttccggtg 602941 ctgtcggcac atatgcgaac attgatccat ttgttgaaca atatgtctgt gagaagctcg 603001 gattgaaagc agcaccgatt tccactcaaa cccttcagcg tgaccgccat gctgactata 603061 tggcaacact tgctttgatc gcgacaagca tcgagaaatt cgctgtggaa atccgcggac 603121 tgcaaaagag tgaaacacgt gaagtagagg aatttttcgc gaaagggcaa aagggttcat 603181 ctgcaatgcc gcataaacga aatccgattg gctctgaaaa catgacaggc atggcgcgcg 603241 tgatccgcgg ctacatgatg acagcttacg aaaatgttcc attatggcat gagcgcgata 603301 tttctcattc ttcagcagaa cgaattattc ttccggatgc gacaattgcg ctgaactaca 603361 tgctgaaccg cttctccaac atcgtgaaga acttaacggt cttcccggaa aacatgaagc 603421 gcaacatgga ccgcactctc ggccttatct attctcagcg tgtgctcctt gctttgattg 603481 acacaggcct gactcgtgaa gaagcctatg atacagttca gccgaaagca atggaagcgt 603541 gggaaaaaca agtgccgttc cgcgagcttg tggaagcgga agagaaaatc acgtcacgtc 603601 tttctccaga aaaaattgct gactgctttg attacaatta ccatctgaaa aatgttgatc 603661 tgatctttga acgtttaggt ttagcataga agaagctttt agcggcttct tctaagccgc 603721 cgcagtttga aaattcccaa cattcgggtt aggaggcctt ccgtgaatat tgtgaagaat 603781 gaacttttat acgaaggaaa agcaaaaaag atctacaaaa ccgatgacga aaacacgctg 603841 tatgtcgtgt ataaagactc cgccactgcc tttaacggcg agaaaaaagc agaaatcagc 603901 ggaaaagggc gcttaaataa tgaaatttca agcctcattt tcaaacacct tcatgctaag 603961 ggcattaaca atcattttat cgagcgcatt tcggaaacgg agcagctcat taaaaaggta 604021 acgattgtgc cgcttgaagt cgtggtaaga aatgttgtgg caggaagcat gtccaaacgt 604081 ctcggcattc cagaaggcac ggagcttgag cagccgatta tcgagtttta ctacaaggat 604141 gacgcgctgg gtgatccgct catcacagaa gatcatattt ggcttttgaa ggcggcgact 604201 cctgagcagg tagaaaccat taagtccatt acaacaatag taaatgaaga gcttcaaagc 604261 atcttcgacg attgtcatgt cagattaata gatttcaagc ttgaattcgg tttagatgca 604321 gaagggcaag tgcttttggc ggatgaaata tctcctgaca catgccgctt gtgggataaa 604381 gaaacgaacg aaaagctgga caaagattta ttcagacgca atctgggaag cttaaccgac 604441 gcatacgaag agattttcaa tagactggga ggcattcatc atgtataaag taaaagttta 604501 tgtcagctta aaagaaagtg tactagatcc acaagggagc gctgtccagc atgccttgca 604561 cagtatgact tacaacgaag ttcaagatgt gcgcatcggg aaatacatgg agcttaccat 604621 tgaaaaatct gaccgtgatc ttgacgtgct agtgaaagaa atgtgcgaaa aacttcttgc 604681 gaacacagtg attgaagatt atagatatga ggttgaggag gtagtcgcac agtgaaattt 604741 gcggtgattg tgttacccgg ctccaactgt gatatcgata tgtatcatgc tgtaaaggat 604801 gagctcggcc atgaagtgga atacgtctgg catgaggaaa caagccttga cggcttcgac 604861 ggcgtgttaa ttccgggagg attttcttac ggcgattact taagatgcgg cgccatcgcc 604921 cgatttgcga atattatgcc agctgtcaaa caagcagcgg ctgaaggaaa acctgttctt 604981 ggcgtctgta acggattcca gattttacag gagcttgggc tgctgccagg cgcaatgaga 605041 cgcaacaaag atctgaagtt catttgccgt ccggttgaat tgattgttca gaacgacgaa 605101 accttattca cagcttccta cgaaaaggga gaatcgatta caatcccggt tgcccatggt 605161 gaagggaatt tctactgtga tgacgagacg cttgctacat taaaggaaaa caatcaaatt 605221 gctttcacat acggctctaa tattaatgga agtgtcagcg acattgccgg tgtcgtgaat 605281 gagaaaggca atgtattagg catgatgcct caccctgagc gcgcggtcga tgaactgctt 605341 ggaagcgccg acggtcttaa attgttccag tctatcgtga aaaattggag ggaaactcat 605401 gtcactactg cttgaaccaa gtaaagaaca aataaaagaa gagaaactgt atcagcaaat 605461 gggtgtcagt gatgatgagt ttgcattgat agaatccatt cttggaagat tgccgaacta 605521 cacagaaatc ggaatttttt ctgtcatgtg gtctgagcat tgcagctata aaaactcaaa 605581 gccgattctg cgtaaattcc cgacaagcgg cgagcgtgtg ctgcaggggc cgggggaagg 605641 cgccggaatc gttgatatcg gtgataacca agcggttgtg ttcaaaattg aatcacataa 605701 ccacccatca gctctcgagc cttaccaagg cgctgcgact ggcgtaggcg gaattatccg 605761 tgatgtattc tcaatgggtg cacgcccaat cgctgtattg aactctcttc gatttggtga 605821 actgacttca ccccgcgtga agtacttgtt tgaagaagta gtagcgggta tcgccggata 605881 cggcaactgt atcggcatcc cgacagtcgg cggagaagtg cagtttgaca gcagctatga 605941 aggaaatccg ctcgtcaacg caatgtgcgt cggtttaatc aaccatgaag acatcaaaaa 606001 aggccaggca aagggtgtcg gcaacacagt aatgtacgta ggagcgaaaa cagggcgtga 606061 cggcatccac ggcgctacgt ttgcttctga agaaatgtca gactcgtctg aagaaaagcg 606121 ttctgctgtc caagtcggcg atccgtttat ggagaagctt ttgcttgaag catgtctgga 606181 agtcatccaa tgcgacgcct tagtcggcat tcaggatatg ggagctgccg gtttaacaag 606241 ctcaagtgca gaaatggcaa gtaaagccgg ttctggcatt gaaatgaatc ttgacctgat 606301 tcctcagcgc gaaacaggca tgaccgcgta tgaaatgatg ctttctgaat cacaagaacg 606361 gatgcttttg gttattgagc gcggacgtga gcaggaaatc atcgatattt ttgacaagta 606421 tgatcttgaa gcggtttctg tcggacatgt gacagatgat aaaatgcttc gcctgacaca 606481 taaaggagag gttgtgtgcg agctgcctgt tgatgccttg gcagaagaag caccggttta 606541 ccataagcct tctcaagagc ctgcttacta tcgcgagttt ttggaaacag acgttccggc 606601 tccgcaaatt gaagatgcga atgaaatgct gaaggccctt cttcagcagc cgacgattgc 606661 gagtaaagag tgggtttatg atcagtatga ctacatggtg cgcacgaata cagttgtcgc 606721 tcctgggtct gatgctggtg ttctcagaat ccgcggaacg aaaaaggcgc tggcgatgac 606781 gacagactgt aacgcgcgtt atctctatct tgatcctgaa gtcggaggga aaattgctgt 606841 cgctgaagca gcgcgcaaca tcatttgctc aggcgcagaa ccgcttgcgg tgacagataa 606901 ccttaacttc ggaaaccctg agaagccgga aatcttctgg cagatcgaaa aagcggcaga 606961 cggcataagc gaagcgtgca atgttctcag cactccggtt atcggcggta acgtatcgct 607021 ttataacgaa tcaaacggca cggcgatcta tccgacacca gttatcggca tggtcggcct 607081 aattgaagat acagcgcaca ttacaacaca gcatttcaaa caagcaggag atctcgtata 607141 cgtgatcggc gaaacaaaac cagagtttgc cggaagcgag ctgcaaaaaa tgacagaagg 607201 ccgtatttac ggcaaagcgc cgcaaatcga tcttgatgta gagctgtctc gtcaaaaagc 607261 actgcttgac gcgattaaaa aaggcttcgt tcaatctgcg catgatgtgt ctgaaggcgg 607321 cttaggcgta gcgattgcgg aaagtgtcat gacgacggaa aaccttggcg ctaatgtgac 607381 tgtagaaggg gaagcggcgt tattattctc tgaatctcaa tctcgcttcg tcgtttcagt 607441 gaaaaaagaa catcaagctg cgtttgaagc aactgtcaaa gatgcagttc atattggtga 607501 ggtaacagct gacggaattc tggcgattca aaaccaagac ggacaacaaa tgattcatgc 607561 gcaaacgaaa gagcttgaac gcgtatggaa aggagctatc ccatgcttgc tgaaatcaaa 607621 ggcttaaatg aagaatgcgg cgtttttggg atttggggac atgaagaagc cccgcaaatc 607681 acgtattacg gtctccacag ccttcagcac cgaggacagg agggtgctgg catcgtagcg 607741 actgacggtg aaaagctgac ggctcacaaa ggccaaggtc tgatcactga agtatttcaa 607801 aacggcgaac tcagcaaagt aaagggaaaa ggcgctatcg ggcacgttcg gtacgcaacg 607861 gctggaggcg gcggatacga aaatgttcag ccgctcctct tccgttccca aaacaacggc 607921 agcctggcgc ttgctcataa cggaaatctt gtcaacgcca ctcagctgaa gcagcagctc 607981 gaaaatcaag ggagcatctt tcaaacctct tcggatacag aggttttggc tcacctgatc 608041 aaaagaagcg gacacttcac gctgaaggat caaattaaaa actcgctttc tatgctgaaa 608101 ggcgcctacg cgttcctgat catgaccgaa acagaaatga ttgtcgcact tgatccaaac 608161 gggctgagac cgctatccat cggcatgatg ggcgacgctt atgtggtcgc atcagaaaca 608221 tgcgcatttg acgtcgtcgg cgcaacgtac cttcgcgagg tagagccggg agaaatgctg 608281 atcattaatg atgaaggcat gaaatcagag cgtttttcca tgaatatcaa tcgttccatt 608341 tgcagcatgg agtacattta tttctccaga ccagacagca atattgacgg tattaatgtg 608401 cacagtgccc gtaaaaacct tgggaaaatg ctggctcagg aatccgcagt tgaagctgac 608461 gtcgtaaccg gggttccgga ttccagtatt tcagcggcga tcggctatgc agaggcaaca 608521 ggcattccgt atgagcttgg cttaatcaaa aaccgttatg ttggcagaac gtttattcag 608581 ccgtcccagg ctctgcgtga gcaaggcgtc agaatgaagc tgtctgcggt gcgcggggtt 608641 gtagaaggca aacgcgtcgt gatggtggat gactctatcg tgcgaggaac aactagccgc 608701 cggattgtca cgatgctaag agaagcgggt gcgacagagg tgcatgtgaa aatcagttca 608761 ccgccgatcg ctcatccgtg cttttacggc attgacactt ccacacatga agaactgatc 608821 gcgtcttcgc attctgttga agaaatccgt caggaaatcg gagccgatac cctctcattt 608881 ttgagtgtgg aagggctgct gaaaggcatc ggcagaaaat acgatgactc gaattgcgga 608941 cagtgtctcg cttgctttac aggaaaatat ccgactgaaa tttaccagga tacagtgctt 609001 cctcacgtaa aagaagcagt attaaccaaa taaaacttga aaaatgacat aaaggcagcg 609061 cagttcggct gcctttctct ttctgccctc gttcggggag atattttgaa aagcgcctta 609121 aaggagtgaa taggatgtct gaagcatata aaaacgcagg agttgacatc gaagccggat 609181 atgaagctgt aaaacgaatg aaaaaacacg tggagcgcac gaaacggctt ggcgttatgg 609241 gcagccttgg cggttttggc ggcatgtttg acctgtctga gctttcttat caaaaaccag 609301 ttctcatttc gggaacggac ggtgtcggca caaaattaaa gctcgctttt tccatggata 609361 agcatgacac gattggcgtg gatgctgttg caatgtgtgt caatgacgtg ctggcacaag 609421 gtgcagagcc gctgtttttc ctcgattatt tagcggttgg caaagcggac ccagtgaaaa 609481 ttgaacagat tgtacaaggt gttgcggaag gctgtgagca gtcaggttca gccttagtcg 609541 gcggtgaaac ggctgaaatg ccggggctct atacagctga tgaatacgat attgccggtt 609601 tctcagtcgg agtggcagaa aaggacgaaa tcgtgactgg agaaaaaatt gaagagggcc 609661 atctgttgat cggcctcagc tccagcggcc ttcacagcaa cggcttttcc cttgtcagaa 609721 aagtgcttct ggatgatgcg gagctggacc tcgatacaac atatgagccg tttgaacgcc 609781 cgcttggcga ggaattgctt gaaccgacaa ggatttacgt gaagcctgtg cttgccgcgg 609841 tcaaaagcgg aaaaatcgac ggcatggcgc acgtgacagg cggaggattt attgaaaata 609901 ttccgcgtat gcttccggaa ggcttaagtg cggaaattga tcatggctca tggccgatcc 609961 cgccgatttt ttctttcttg caagagtacg gcaagctaaa ggaagaagac atgttcaacg 610021 tctttaatat gggtatcggt tttgttttgg cagtcaaaga agagcatctg acagatgtga 610081 tcggaacgct tgaaagccat ggcgaaaaag cctatttaat cgggcgtgtg aaaaaaggtg 610141 aaggcgtcac attcggcggt gcggcacttt catgaaaaag tttgcggtat ttgcatcagg 610201 aaacggttca aacttcgaag ccatcgtcac gcgtttgaag gaggagaact gggatgcgtc 610261 agcagcgctc ctcgtttgcg acaaaccgca ggcgaaagtc atcgaacggg cggaagcatt 610321 ccacattcca tccttcgcat ttgagccgaa gtcttatgaa aacaaggctg catttgaaca 610381 agccatcatt gaacagcttc gtcttcacga ggttgaattg attgctcttg ccggctatat 610441 gaggctgatc ggtgatacgc tccttcaagc atatggggga aaaatcatta acattcaccc 610501 atcgcttctt ccggcgtttc ctggaatcga cgcagtcgga caggcgttcc gggcgggtgt 610561 gaaggtggcc ggaatcaccg tgcattatgt cgatgaagga atggatacag gtccgatcat 610621 cgctcaaaag gcaatcgaaa ttgatgaaca tgatacattg gaaacaatcg aacagcgaat 610681 tcacaagctt gagcataaat ggtatccgag tgtgattaaa cagctattag gattaaataa 610741 cagaggtgaa aaggcatgac cattaaacgt gcattaatca gtgtttcaga taaaacaaat 610801 ctcgttcctt tcgtaaaaga actgacagag cttggcgttg aagtcatctc cacaggcgga 610861 acgaaaaagc ttcttcaaga aaacggtgtg gatgtgatcg gaatttctga agtgacaggc 610921 tttcctgaaa ttatggacgg ccggttaaaa accctacacc cgaatattca cggcggcctt 610981 ctggcggttc gcggcaatga agagcatatg gcgcagatca atgaacacgg gattcagccg 611041 attgacctcg ttgtcgtcaa cctctatcca tttaaagaaa cgatttctaa agaagacgtc 611101 acgtatgaag aagcgatcga aaatatcgac atcggcggac ctggcatgct gcgcgcggca 611161 tcaaagaacc atcaggatgt cacggttatc gtcgatccgg ccgattacag cccagtgcta 611221 aatcaaatca aagaagaagg cagcgtatct cttcagaaaa aacgcgagct cgcggcaaaa 611281 gtattccgtc atactgcggc atatgatgca ctgatcgctg actatctgac aaatgttgtc 611341 ggtgaaaaag aaccagagca attcactgtg acatttgaga aaaaacaatc gcttcgctat 611401 ggagaaaacc cgcatcagga agcaactttc tatcaaacag ctcttcctgt caaaggctcc 611461 attgcgcaag cagaacagct tcacggaaaa gagctttctt acaacaacat taaagacgcg 611521 gatgctgcag ttcaaatcgt tcgtgaattc actgaaccgg ctgctgttgc tgtgaagcat 611581 atgaacccgt gcggcgtggg aacaggaaaa acgatcgcag aagcgtttga cagagcgttt 611641 gaagcggata aaacatctat cttcggcggc attatcgcgc tgaaccgtga agtggacaag 611701 gcaactgccg aagcgcttca caacattttc ttagaaatca tcattgcgcc ttcattcagc 611761 caagaagcgc tcgacgtcct gactgcgaag aaaaatctcc gtctgctgac gcttgacgta 611821 tccgccgctg ttcaaaagga aaaacagctg acatccgttc aaggcgggct gctgattcaa 611881 gatttagata tgcacggctt cgatgatgct gagattagca ttccgacaaa aagagagccg 611941 aacgagcaag agtgggaaga cttgaagctt gcttggaaag tcgtgaagca tgtgaaatca 612001 aatgcgattg ttctcgcgaa ggacaacatg acagtcggcg tgggagcagg ccaaatgaac 612061 cgcgtcggat cggcaaaaat cgcaatcgag caagcagggg aaaaagcgaa gggcagcgcg 612121 ctcggttcgg atgcatattt cccaatgcca gatactgtcg aagaagcggc aaaagcgggc 612181 gttacagcca tcattcagcc aggcggatcg atccgagatg aggattccat caaaaaagcg 612241 gatgaatacg gcattgccat ggtattcacc ggcatcagac acttcaaaca ttaaggggat 612301 gaaaacgacg tgaatgtatt aattatcggt aaaggcggaa gagaacatac gctggcgtgg 612361 aaggcagcgc aaagcagcct cgtcgagaat gtatttgccg ctcccggaaa tgacggcatg 612421 gcagcttccg ctcagcttgt aaacattgag gaaagcgacc acgcagggct tgtctcattt 612481 gcaaaacaaa atcaggtcgg cctgaccatt gtcggccctg aggttccttt aattgaaggt 612541 ctggtggatg aattcgaaaa agcgggctta catgtgttcg gtccgtcaaa agctgcggcg 612601 atcatcgaag gaagcaaaca gttcgctaag gatttaatga agaaatacga cattccgacc 612661 gcagaatacg agacgtttac atcctttgat gaggcgaagg catatgtgca ggaaaaaggt 612721 gctccgattg tgataaaagc agatggactt gcagctggaa aaggcgttac tgtggctatg 612781 acagaggaag aagcaattgc gtgcttgcat gactttcttg aagatgaaaa gttcggtgat 612841 gcgagcgcgt ccgttgtcat tgaagaatat ctttctggtg aagaattttc tctaatggcc 612901 tttgtcaaag gggaaaaggt gtatccgatg gtgattgccc aggatcacaa gcgggcgttt 612961 gacggagaca aaggcccgaa tacaggcggc atgggcgcct actcgccagt tccgcaaatt 613021 tcggaagaaa cggtccgcca tgctgtagaa acgatcgtta agccggctgc aaaagcaatg 613081 gtacaagaag gccgttcctt cactggcgtt ttgtacgctg gattgatgct tactgaaaac 613141 ggctcgaagg tcattgaatt taatgcccgt ttcggcgatc cggaaacaca ggtcgtgctt 613201 ccgcgcatgg aatctgatct ggtacaggtg cttcttgatc ttttagatga taaggaagtt 613261 gacttaagat ggaaggatac cgcggcagtg agtgttgtgc ttgcatcaga agggtatccg 613321 gaaagctatg caaaaggcac gccgatcggc agccttgcag cagaaactga gcaggtcgtg 613381 gtcttccatg ccggaacgaa agcagaaggt ggagagttcg ttacaaacgg ggggcgcgtc 613441 gccaatgtga cggcttttga tgaaacgttt gaagcggcta gagaccgagt gtacaaagcg 613501 gttgatgaaa ttttcaaacc gggactcttt ttcagaaaag acattggggc acgcgcttta 613561 aaggctgccc aaaaataagt gaggaaaacc cgcagaatag ctgcgggttt tttgttatca 613621 aaaagcggga tggcagctag aagaagaaag cacaacgagc gtggttggtt ttccatgggc 613681 catcgaggtg tcaataaaat cctcaagcgt atgtaccgat tcagtcacga cctttgtcac 613741 atagctgtac atccccgtga tgcggtggtt ttctgctaca tcaggatgcg atgttgcaaa 613801 ggcggcgtag tgcttgcagc ttttcggctc catgagaata aaagcggtga catgcttgtt 613861 tagtttttcg taacagatat tcgcgctgta gccggtaatc actcctttgt cttccagctt 613921 cctgacacgc tccgccgcgc ttggcgagct gagtccgaca agctttccca gctcaaccat 613981 cgttaatctg ccgtttcgct gcaaatgcga gagaatctga aggtctgtat cgtccatttg 614041 tctggctcct ttacatattt aggcgaatga atgaaaattc ctttgatcgt aaggtaatgc 614101 tgttgattta acttcattgt agcatatgga tgccgtctta ttttttctat aataaagcca 614161 tcaatcagag agggggcatc atgttgccag aattgcagcg ctctattact tggatacaag 614221 ggacggcgtt aacgattggg gcggttttag gatgcgggat attaatcctg ccgtctgtca 614281 ccgcggacac ggccggcccc gcttctttat ttgtttgggt gttcatgtcc ttcttatcct 614341 tttttcttgt cggcacgctg gcccggcttg tgaaaatagc gcctagcgcg ggaggaatca 614401 cggcttatgt gcagctggcc tttcagaaaa aagccggggc tattttgggc tggatcatgt 614461 tagggtccgt tccgatcggc gttcccatca tcgctttgac tggcgcgcat tacgtcagtt 614521 acatcacaga ggcggccgat tggcagatta cattgattgc tggttgcatg ctggctatat 614581 ctattttgct tcatatgaga gggattcaac tatcagcaaa cattagtaca ctcgttatat 614641 gtgtcatcgt atttctgctt gtcacttcta ttgctgtgtc attgccacac gtcacgatag 614701 cagaattcaa gccgtttctt ccgcatggct ggtctgccgc tggatctgtt tctgttatga 614761 tttttttctc ttttgtaggc tgggaaatga ttaccccgtt ggctgaggaa tttcatcgtc 614821 ctgaaaaaga tgtcccgctc agcttgtttt tggcagcgtc ttgtgtggcg gggctgtata 614881 tcatgctgtc atttgtgacc gtgggtactc attcatatgg agagaatgga gaaattgcat 614941 cgcttgccat gctcatttca aaaggagcag gagaaagcgg tgtatatgtc acggtatgtt 615001 tagcgctgtt tattacattc gccaccatcc atgccaatat tgccggtttt tcaagaatgg 615061 tgtacgcatt ggcgagagag gggcacatac ccgtattttt tggaaaactc agtgcgacaa 615121 aacgtacgcc tattcgcgtt ttgacagcga tggccgcagt gtttggctta gtgcttgcag 615181 cgcatggtct gtttcaaatc gatttgacga ctctgttgaa agggccgagc gcggctttta 615241 tcgcatctta catatgtaca atggcggcag cactgaaact gctgggcagg agagatatag 615301 gctggtggat ggcgctcggg gcatttgtgg cgtgcgcggt gatttattca ttcagcggct 615361 gggcactgct ttatccggca gtgctggcag ctgcaggata tttctatatg aaaacaaagg 615421 gtgggcataa aaaaaagctt gatcacgttt tgtgatcaag cttttccatt tatccgtttt 615481 gatgctcgtt atttccagaa tcgctgtgtt gaaacatgta ggtcacagga cagaagcgca 615541 agattcccga acccgctttc atggccccca taaagatgta aaagagatgc attctgcacc 615601 aaggtttttt cgtaaacttt gcactggcgg ctgacataat cgtcaatccg caggcgattc 615661 tgaacacggc attgatgaga ctgatgtttg gcttcaagga aatccgctcc ttttacttaa 615721 aaaagttttt taatcgaacc ttcaaaaatt tgtaacgttt ttatcgtgcg tgatgaggaa 615781 ggatgtgata ccatgagtct aatacatgta aaggagagta tgtgaatgtc cgaacgcacc 615841 tttaactgga aaaacaaaga catcagggca caggttgatg ttgtagactc aaagctgctt 615901 ccaacgctcc ttttacggaa tgctctcgtc ttaaatccat atgtaaaaca atggctgaaa 615961 aaaaacattt ggatttatca ggaccgcatt gtttatgtgg gtcatgaact tccgaataga 616021 gccgaagaaa ttcatacgat tgattgtgaa ggaaaataca ttgtgccagg ttatattgaa 616081 ccgcacgcac atccttttca aatatataat ccccaaacac tggcggaata tgtgtctcaa 616141 tacggaacaa cgacattcgt gaatgataac ttatttttgc ttttgcaaag cggaaaaaag 616201 aaagcgctta cgattttgaa tgaactcaaa aagcagcctg tccagtattt ttggtggtca 616261 cgctatgacc tccagaccga ggttctgaac gaggaccacg tccttccatt tgacgtcaga 616321 aaacagtgga ttgaacatcc ggatgtgatt caaggcggag aaatgaccgg atggcctcgc 616381 ctggtagatg gtgatgattt aatgctccac tgtatgcaag ctacaaagaa acagagaaaa 616441 cgtattgaag ggcattttcc cggcgcttct gataaaacgc ttacaaaaat gaagctgttc 616501 ggtgcggatt gtgatcatga agcgatgaca ggtgatgaag tgatgagaag gctggaactg 616561 ggctattatg tttcccttcg gaactcttcc attcgccccg atgtaagaaa aatcttgcaa 616621 gagctgcatg agaagggctt ccgctattat gaccacttct tttacacgac agatggcgca 616681 accccgaatt tctataaagg cggcatgaca aacgagctga ttcgcattgc gttagaagaa 616741 ggcgtacctg caatcgacgc ctacaatatg gcatcattta atatcgcaaa gtattaccaa 616801 atggatgatt atttaggagt tgtcggaccg ggcagactgg catcgctaaa catactggaa 616861 gatccgttaa atccgaatcc agtgactgtt ctgtcaaaag ggaccattct gcgtgaaaac 616921 ggctgtgatt tgaaggcgtt tacaaagacg gactggcaca aaggcggtct tgtcccgctt 616981 gagctttcat atgatatgac gatggatgac ttgcagtttt ctatgccgat gggcgtgaaa 617041 atgcggaatg cggttattat ggagccatat atgattgaga tcgacaattc gatggaacag 617101 ctctcgtttg accatgatga aagttatttg acgatgctcg acagacacgg gaaatggcgc 617161 gtcaatacga tgataaaagg gtttgcctca agcgtgcagg gatttgtaag ctcctttacg 617221 acgacgggcg acattgtcgc gattggaaaa aataaagcgg atatgctgct cgctttcgcc 617281 cgcatgaaag aaatcggagg aggaattgtt ttagcggaga acggaaacat tctgcatgaa 617341 atcccgcttg cgctgtgcgg ctgcgcctct tcggaagcgt atgaagacgt gcttgagaag 617401 gaacaaaagc tgagagatct tttgactgaa agaggctatg agttttgcga tcctatctat 617461 acgctgctct ttttgcaaag tacgcacctt ccgtatatac gcattacgcc aagaggaata 617521 ttcgacgtca tgaaaaaaac tgtactcttt ccatcgataa tgcgttaaaa tataaaagag 617581 cagggagccg acatatgaaa aaatggatga cagtttgcgc gctgtgtttc gtgttttttc 617641 tgctggtatc ctgccagcag aaggatgctg tcccggatac tgcaaagaag ctgaaagctc 617701 ctttaacggg gctaaagact gaacagaaag tgactgaacg ccgccctgtt gctgttgtgg 617761 tgaacaatca cccgaaggcg aggccgcagt cgggtctgtc taaagccgac attgtcatag 617821 aagcgctagc cgaagggcaa atcacaagat ttctggccat tttccaaagc cagatgcctg 617881 aaactgtcgg acctgtgcgg agcgcgcggg aatatttcgt cactctcagc aatggctttg 617941 acagcatatt tgtccatcac ggctggagtc ccggcgccaa aaagcagctg gaatccggag 618001 ctgccgatta tatgaacgga ttggattttg acggaagctt attttggaga gctgatttca 618061 gcaaaccgcc ccacaattcc tatacgtctt atgattacat aaaaaaggcg gcagaacaaa 618121 agggttataa gctgaagcag gaaacaaatc cgctgctgtt tcaaacatca gatgcaaaac 618181 ctgcaaatga atcttacaat gttcgggtag attatggaac aaataacgtt acaaatcttg 618241 tcgaatacaa ctatgataaa aaagctgaat tttatacaag aagctctgat ggtgtcataa 618301 cgacagaccg ggaaaccgga aagccggttg caatgcaaaa tattttcatt gttgaagcca 618361 gccatcatat tattgatcaa gatggaaggc gggacatcga cttggaatca ggaggaaaag 618421 gtctgttgtt tcagcacgga aacgtcattg aaacagactg gaaacaagtg aatggcagaa 618481 ttgtgccggt aaaagacggc aagtggcttc cgtttgtgcc aggaaagact tggatcaata 618541 tcgtacctga tcttgatgcg gcttccatta gtaaaggaga aggtgtgtaa cgatgcaaat 618601 cgataaatta cgcggcaaag agctggacca gttatttaac tcgatcttat cgctgaaaga 618661 cctggaggaa tgttaccgat tcttcgatga tctatgcaca attaacgaaa ttcaatcgct 618721 ggctcagcgc cttgaagtgg cgcgcatgct tcgcgaagga aacacgtatc ataagattga 618781 aacagaaaca ggcgcttcca cggctacgat ttcccgtgtg aaacgctgct taaattacgg 618841 aaatgacgct tatgaaatgg cgcttgaccg tgtgaaggag acggaaacag agtcttcttc 618901 caaataaaaa accgccctgc cgtctggcaa gggcggtttc tttatgaaac aaattgatgg 618961 atcaggttgt cgatattgat gatactgcca tcctctttcc gatagacaac atgctccttg 619021 gaaaaatgaa tcggcgaatt aatccctgct gcggctgcaa ggttaaatag tccctcgcgc 619081 aatgaaataa cgtagttgca gacacgatgc tgtttttcct caacgctcag tgctttttgc 619141 aatttcggat ctgtcgtcgc cacacctgcc ggacaggtgt tggtgtggca gacgagagcg 619201 cggatgcagc caacggaaaa catcatgccg cgtgcgatgt taacaaagtc agcgccgagg 619261 gctaaggcga ccgcgatttt atcaggagtc aggagctttc cggaagcaaa gattttcagc 619321 tggctgcgca agccgtactg tttaagaagc gtgtccacaa taggcagcgc tgtcataatc 619381 ggaaggccga ctgtatccgc gagctcgtaa aaggaagctc cggtaccgcc ttcacttccg 619441 tcgatcgtga taaaatccgg atgctttccg cttttctgca tatgagagaa aagctcatgc 619501 aattcttcag gatgccctgc gaccagtttg atgccgactg gcttttgtcc gacatctcta 619561 agtttttcaa taaagtcgag catttcagga gggtttgaga attcataaaa gcggttcggg 619621 ctgtcaatcg actttccagg ttcgacattc cgaatgtctg ccacttcctc tgatactttg 619681 gcgccgtcca catggccgcc gcgggttttc gctccttgtg ccagctttag ctcaaacgct 619741 ttaatctggt caatcctgct ttttctttta aattcctccc acgaaaattc cccgtttctt 619801 ttgcgcacgc cgaataggcc cggtccgatt tggcaaatga tatcggcgcc gccctttaag 619861 tgatattcag acaatccccc ttcacctgta ttcatccagg tgccgcctgc cagatggagc 619921 ccttttgaga gcgccgtaac agcccgttct ccaagagaac cgtagctcat ggcagactgg 619981 ccgactaagc ccttcacata aaatggcttc tcgcatgtat gctcgccaat cacctgtaca 620041 tcatcaggat ggagaaaata cgggtctgcc ttgatatgtt cggcatgctc cttgcgtttg 620101 aacagattgt cagcatccat tttatagatt tgggtttcaa tttttggcgt ttgatttaca 620161 tgcatttctt ccctttgttt tggaaacata gcgttacgga tataatagcc aggtttatca 620221 aaatctctta cagatccaaa gcccatcatt ctgcttttgt atttgccgga gatgacggtt 620281 tgctcatatt cctttcgtga aaatggctgc tcttcattgt cattgctgta taaatactgt 620341 ctgagctccg gcccgatttt ttcaaggata taccgaaacc ttccgatgac gggatagttg 620401 cgaagaattg agtgctcctg ctgtttttca tcctttatgt agatccaggc aaacaagacg 620461 atcgggatag cgatgatccc aatgataaat gcgatgagtg ctattatgat ggtttccatc 620521 tctcagcctc cctttttatg taaccatttc cacagtagaa cactttccaa acaatagcag 620581 aaggaatctg gtgaaaaatg tgtgctcctg ccgatacagg actcaccatg caggtactgc 620641 catatgctct ctttttttat gaaaaaagaa tcaaaacacc tttttcagtg aataacgaga 620701 ttaacggctt tttccgtttt tccgcgctat gtgaatttgt tataatgttt aaatggtaac 620761 aaacgaatgg aggaacgtat gacgtgtacg atgtaacgga gtggaagcat gtctttaaac 620821 tcgatccaaa taaagatttg cctgacgaac agctggagat tctttgcgaa tcaggaacgg 620881 atgcggtcat tatcggagga agcgatggtg tgacagagga taatgtcctg cggatgatgt 620941 ctaaggtaag acggtttttg gtgccgtgtg tcctagaggt atcagcgatt gaagcgattg 621001 ttcccggctt tgacttatat tttattccga gtgtattaaa cagcaaaaac gcggattgga 621061 ttgtcggaat gcaccagaaa gccatgaagg aatacggaga actgatgtct atggaagaaa 621121 tcgtggcgga gggctactgc atcgcaaatc cagattgcaa agccgcggca ctgactgaag 621181 cggacgccga tctgaatatg gatgatattg tcgcctatgc gcgtgtgtcg gagctgctgc 621241 aactgccgat tttttattta gaatacagcg gcgtgcttgg agacatagaa gctgtcaaga 621301 aaacgaaggc tgtattggaa acgtccacct tgttttacgg cggcggcatc aaggatgcgg 621361 aaacggccaa gcagtacgca gagcatgcgg acgtgatcgt tgtaggcaat gcggtgtatg 621421 aagattttga cagggctttg aaaacagtag cggctgtgaa aggcgagtag taaattgtac 621481 ggatttggtt tatgatagaa cgtatgtttt gtataggcgg gtgaacaaat tttgaattat 621541 attagcaatc aattactaag cggtttaaac cccgttcagc aggaagcagt caaaacaacg 621601 gacgggcctc ttttgctgat ggcgggagcg ggtagcggaa agacgcgtgt cctgacccat 621661 agaattgctt atttaatggc agaaaagcat gtggcgccgt ggaacattct ggcgatcaca 621721 tttacaaata aagcggcacg cgaaatgaaa gaacgtgtgg aaagcatcct cggacccggc 621781 gcggacgata tctggatctc cacattccac agcatgtgcg tgcggatctt gcgcagagat 621841 atcgaccgga ttgggatcaa ccgaaatttc tccatccttg atacggctga ccagctttca 621901 gtgatcaagg ggattttgaa ggagcgcaat cttgatccga agaagtttga cccgagaagc 621961 atcctcggca cgatcagcag tgcaaaaaac gaattgaccg aaccggagga attctctaaa 622021 gttgctggcg gctactacga tcaggtggtc agcgatgtat atgctgatta tcagaagaag 622081 ctattgaaaa accagtcgct cgatttcgac gatttaatta tgacgacgat taaactgttt 622141 gacagagtgc ctgaagtgct tgaattttat cagcgcaaat tccagtacat ccacgttgat 622201 gagtatcagg atacgaacag ggcacaatac atgctcgtta agcagcttgc cgagcgtttc 622261 cagaaccttt gcgttgtggg ggattctgat cagtcaatct acagatggcg cggcgcggat 622321 atcaccaaca ttctttcatt tgaaaaagat tatccgaatg caagcgtgat tttgctagaa 622381 caaaactatc gttcaacgaa acggattttg cgcgcggcta acgaggtcat taaaaacaac 622441 tctaaccgca aaccgaaaaa tttgtggacg gaaaatgatg aaggcatcaa gatttcctat 622501 tatcgcggtg ataatgagtt cggtgaagga cagtttgtgg ccggcaaaat tcatcagctt 622561 cacagcacag gcaagcggaa gctgtcggat atcgccatat tataccggac aaacgcgcag 622621 tcccgtgtga ttgaggaaac gcttctcaaa gcgggcttga actataacat tgtcggcggc 622681 acaaagttct atgacagaaa agaaattaaa gacattcttg cgtacctgcg cctcgtatcc 622741 aatccggatg acgatatcag tttcacgcgc attgtcaatg tgccgaagcg cggagtcggc 622801 gcgacatcac ttgaaaaaat cgcttcgtat gcggccataa acggcttgtc ctttttccaa 622861 gcgattcagc aggttgattt tatcggcgtc agtgccaaag cggcaaacgc gcttgacagc 622921 tttagacaga tgattgaaaa cctgaccaat atgcaggatt acttatccat tacagagctg 622981 acagaagaaa ttcttgataa gacggaatac agagaaatgc tgaaggctga gaaatcgatc 623041 gaagcccaaa gccgtttaga aaatatcgac gagttcctgt ctgttacgaa aaactttgaa 623101 cagaaaagtg aagacaagac actcgttgcg ttcctgacag acttggcatt gatcgcagat 623161 attgatcagc tcgatcagaa ggaggaagag tcaggcggca aggatgcgat caccctgatg 623221 acactgcacg ccgcgaaagg actggagttt ccggttgttt tcttgatggg gcttgaagaa 623281 ggcgtcttcc cgcatagccg ttcactcatg gaggaagcgg aaatggaaga agaacgccgc 623341 cttgcgtacg ttgggattac aagggcggaa caggagcttt atctgaccaa tgctaaaatg 623401 cgcaccttgt ttggccggac aaatatgaac ccggaatctc gcttcattgc tgaaataccg 623461 gatgatttat tggaaaacct aaatgagaaa aaagaaacaa gagcgacgtc tgcgagaaaa 623521 atgcagccga gacgcggccc tgtttcacgc ccggtatcct acgccagcaa aacaggcggc 623581 gacaccttga actgggcagt cggagataag gcgggccata aaaaatgggg aacaggaact 623641 gtcgtcagcg tgaaaggcga aggagaaggg acagagcttg atattgcctt cccgagccct 623701 gtcggcgtga aacgcctgtt agcagcattt gctcctattg aaaagcagta attgaagagg 623761 aaaggaagaa gcagatggac aaagaaacag cgaagcagcg ggcagaagaa ctgcgccgca 623821 ccatcaacaa gtatagctat gaatattaca ccttagatga accgagcgtc ccagatgccg 623881 aatacgacag attgatgcag gagctgatcg cgatcgagga ggagcaccca gacctcagaa 623941 cgcctgactc tcctacgcag cgcgtcggcg gagccgtgct tgaagcgttt cagaaagtca 624001 cccacggcac accgatgctc agtctgggca acgcctttaa tgctgatgat cttcgtgatt 624061 tcgaccgccg tgtgcgccag tccgtcggcg acgatgtggc gtataatgtg gagctgaaaa 624121 tagacggtct tgctgtttct ctccgttatg aagacggcta ttttgtcaga ggggccacaa 624181 gaggtgacgg gacgacggga gaggatatca cggagaatct gaagacgatc cgcaatatcc 624241 cccttaaaat gaaccgtgag ctgtcgatcg aagtgcgcgg cgaggcgtat atgccgaagc 624301 gttcgtttga agcactcaat gaggaacgga ttaaaaatga ggaagaaccg ttcgccaatc 624361 cgcgaaatgc cgcggcggga tctctcagac agctcgatcc gaaaattgca gcgaaacgaa 624421 acctcgatat cttcgtctac agtatagcgg agcttgacga gatgggtgta gagacgcaaa 624481 gccaagggct tgattttctc gacgaactcg gatttaaaac gaatcaggaa cgaaaaaaat 624541 gcggcagcat agaagaagtc attacgctga tcgatgagct tcaggcgaag cgcgcggacc 624601 tgccgtacga aatagacggc attgtcatta aagtcgattc tctcgatcaa caggaggagc 624661 tcggttttac ggcgaaaagc ccgcgctggg ccatcgcgta taagtttcct gctgaagagg 624721 tcgtgacgaa gcttctcgat atcgaattaa atgtcggcag aacgggtgtg attacgccga 624781 ctgcgattct tgagccggta aaagttgccg gcacaacggt ctcaagagca tcccttcata 624841 acgaagattt aattaaagag aaggacattc ggattttgga taaggttgtc gtcaaaaaag 624901 cgggcgatat catcccggaa gttgtgaatg tcctcgttga ccagcgcaca ggagaagaaa 624961 aggaattcag catgccgacg gaatgtcctg aatgcggcag tgaactcgtc cggatcgaag 625021 gagaagtggc gcttcgctgc attaaccctg aatgtccggc gcaaatccgg gaagggctta 625081 tccatttcgt ttcccggaat gccatgaaca ttgatgggct cggcgaacga gtgatcacac 625141 agctgtttga ggaaaacctt gtccgcaatg tggcagattt atataagctg acgaaggaac 625201 gagtcatcca gctcgagcgc atgggcgaaa agtccactga aaacctgatc agctccatcc 625261 aaaaatcaaa agaaaattcg ttagagcgcc tgctgtttgg gcttggcatc cgttttatcg 625321 gatcaaaggc cgcaaagacg cttgccatgc attttgaaag cttggagaac ctgaaaaaag 625381 cctctaaaga ggaacttctc gcggtagatg aaatcggtga aaaaatggct gatgctgtga 625441 tcacctattt tcataaagaa gaaatgcttg aactcttgaa tgaacttcag gagctgggcg 625501 taaacacgct ctacaaaggc ccgaaaaaag taaaagcaga ggacagcgac tcttactttg 625561 ctggtaaaac aattgttctg acaggaaagc tggaagagct gtcaagaaac gaagccaaag 625621 cgcaaatcga agcgctgggc ggaaagctga ctggaagcgt cagcaaaaac acagacttag 625681 tcatcgccgg agaagcggcg ggaagcaagc tgacaaaagc acaagagctg aacattgaag 625741 tgtggaatga agaacagtta atgggagagc taaagaaata agaggagtgt tttctattga 625801 aaaagacgtt ggcattggcg gcaacggcgg cagtattaat gctgtctgcc tgctcgtcag 625861 gtttcggggg ggagaaggag gaagagatta cgcaaaagac ggcgaaatcg tcagaaaaag 625921 cgattgtccc gaaatataat atctctgact cctattacaa aatggtgctg ccgtttaagg 625981 caggcaaagc gcgcggctta acaacggaac agctgaatac aaggctggac attgacgaat 626041 ttgaaacagg gctgatgcgc cttgcccaag attctttctc aactgacgat tatctgttcc 626101 aagaaggaca atatttagat gaggatacag tattaagctg gctggcacgg aaaaaaacgg 626161 gctctgattt gaaaaaagcc gaaaaagaag ataagaactt caaaaatgaa ggcttgaacc 626221 cggcgctccc gagttctggt tcaacagaag aaaagaacga aagcagccca atttatttag 626281 catccatgct tgagcacgat tatttagtca gaaaagacaa gaattctatc cagcttggcg 626341 gcgtcatgat cggactggcg ttaaactcag tgtattacta tcgtgaaaaa actggcgacc 626401 cgcaaaaaga agtggagatt aaagacagca cgcttcgcca gcagggagaa aaaattgcac 626461 aggaggttat taaccgcctc cgcaaaaaag ataacttgaa gaatgtgccg attaccgtgg 626521 cgctctacaa gcaggcgtca aaaacatcga ttgtgccggg gaacttcatc gccaaaacag 626581 aggtcaaagc aggctctact gatatctcaa attgggatga catcaatgaa aaatatgtat 626641 tctatccggc ggatacaacc acagcagaaa agtacccgga tgacaccgag gtctttaagc 626701 ggttcaaaaa ctcaattgaa gaatatttcc cgaactatac aggcgttgtc ggtacagcgc 626761 tgtatgaaaa tgatgaaatg aagaaaatga agattgacat accaatgcaa ttctacggaa 626821 aaagtgaagt tgtcgcgttt acccagttct taacgggtga agtgatggac tactactcta 626881 agagctcagt tgatgtcgaa gtcaatatca cgtcctcaga cggacaggaa gcggtcatta 626941 tccgcaatgc cggagataaa gagccgactg ttcacattta tgactgatag aaaacccttg 627001 tgccatattg gcacaagggt ttttatgtta caattaacag gaaaagggaa aatattttca 627061 cttctgccga aacacaaatc aaggggaggt atgttgatgc tggaaatcgt gtgaaaacaa 627121 tcattatcaa atctatagca atgaaaggat gttagacgtg cataaagata tcaaaaaaat 627181 atttcatgaa gagcaggttt tggcagaagc tgcagcgaga tacggtttct caaaagatca 627241 ggtgcgtttt ctggctgatg cggaaaacta tgtatatgaa tgtatgaaag acaatcaacc 627301 ttatatttta aagattaccc atacgattcg gagatcttct gattatatga tgggagagat 627361 ggaatggctc cgtcaccttg caataggggg aatttcagta gccaaaccgc tcccgtcgct 627421 gaacggaaaa gacgtagaag cagtgccgga cggaaacggc gggtcatttt tattgagagt 627481 gtatgagaaa gcgccggggc aaaaagtgga tgaatcggac tggaatgaaa cgctatttta 627541 tgagcttggc agatacacag gcagcatgca cagcctgaca aaaagctaca aattgagcaa 627601 tcccgctttc aaaagacagg aatgggatga agaggagcaa ttaaagctga gaaaatatgt 627661 gcctgaagat cagataaagg tgtttcagca agccgattct ttgatgaatg aactgcggag 627721 gctcccgaaa agccaggaca actacggctt ggtgcatgcg gatctgcacc atggcaattt 627781 taactgggat catggcaaaa tcacggcatt tgattttgat gatatcggct acaactggtt 627841 tgttaacgat attagcattc ttctctacaa tgtcctgtgg tatcctgttg tgccatatga 627901 tgataaagct gcgtttacag aagaatttat gacgcatttt atgaaagggt actgggagga 627961 aaatgagctt gaccctgcat ggctgatgat aatacctgat ttcctccgcc ttcgccatat 628021 gctgatttac ggattgctgc atcagatgtt tgaccttaac acaataggag aagaggaaaa 628081 agaaatgctg gccggtttca gaagagatat agagaatggc acgccgatta cagcatttga 628141 tttttcagca ctggtgtaga tagaaaaagc caatgggatt ccagtcccat tggcttttat 628201 aatgtatcac acttcacgcc gactacgcct tcaatggctt taatgtcata gtagacatcg 628261 gtcgtgtatc tgtttttatg gacgcggacc ttcacttcca taattggaaa atccttttcg 628321 cctaggtcgt cgatccgaac ggagtgtgct ttgatatctc ttcttttcat ttcttttaaa 628381 atctctgtca ttttgtcttt atcagaaagt gacattctga tgcggatgtc tttttcctgc 628441 aggcggtcgg ggccgatttt tctgaccacc catgggagaa attccacact gatcaggatg 628501 aacagaagac tggcaaacgc ttctttataa aaaccggctc ccgtagcaag cccgagcccc 628561 gctgcccccc agatcatggc cgatgtcgtc aggccggaaa tgacatcatt gctttttcgc 628621 aggatgacac cggcgccgat aaacccgacg ccggagatga tttgtgccgg cagacgaagc 628681 ggatccatca tgatgcggta gtatttaggg aaatgatatg ccgcattaat actgacgatc 628741 gtcagcatgc atgagctgac tgcgatgaca atacaggttt ttaatccgag cggcttattt 628801 tttaattcgc gttcaagccc gatgaccatg ccaatcaatg tggcaatgcc caatttcaat 628861 aaaatatcag gatcaatata ccagctcaac agcaaacttc ccccttctct atggtgtttt 628921 taaataaata tgattttctc acagtattta tagcaaaaca agagcacaaa agccaccaag 628981 ctgcgcttga tggcttattg cttacttttt gcgttttaac agcttttcca tgacaccgaa 629041 taatcggtaa gaggcttttg caggacgttt tgtgatcatg ctgacaatga tgccggcaat 629101 catactgaga ataaacccag ggatgatttc gtacacaccg gttgattttg ccaggccggt 629161 tgtaatccag atcaacacgg tcgcagcccc gacaatcatg gcagcaagcg cgccccattc 629221 gttcattcgt ttccaataca gactgagcag aatcgcaggc ccgaaagctg aaccgaagcc 629281 ggcccaagcg tatccgacca aatcaagaat ggtgctgttc gggttcaatg acaagagtac 629341 cgcgataacg gcaatgacta agacggacaa tcgcccgatc atgaccaatt ctttatcaga 629401 agcttttcgt ctgaaaaatg accggtataa atcctctgtt acagcacttg ctgtgaccaa 629461 gagctgtgag gaaatcgaac tcatgatggc agccaaaata gctgacaata agaaccctgt 629521 aattaatggg tggaacaaga ttttagagaa gataatgaaa atcatctccg gatcttttac 629581 agcaactccg aatttatggg cgtatgcaac accgattaaa cccgtcagca cggaacctag 629641 aactgtaatg atcatccagc tcatgccgat tcggcgtgca ggttttaaat ctttaatgtc 629701 tttaatggcc ataaatcgga cgatgatatg aggctggccg tagtagccca acccccaggc 629761 taaataggaa ataatgctaa tgacgctcgc gcctttaaaa atatccaata aatgtggatt 629821 aacagcgtcg atttcatgga aagtcggagc aacgccgccc acatgggtaa aagcaacgat 629881 cggcacaagc actagtgctg caaacatgat cgcaccctgc acgaagtcag tcagactgac 629941 agcaaggaaa ccgccaaaca gtgtgtataa cacgacaact gcggtggtca gaaacaggcc 630001 taatttgtaa tccgcaccaa aagcagattc aaacagccgt ccgccagata ccataccgga 630061 agaggtatac aatgtgaaaa agatcatgat gatcaatgca gatacgattt tcagcagtga 630121 tgaagaatgc tggaatcgtt tatcaaagaa atcaggaatt gtaatcgcat catctgccgc 630181 ttctgtataa gcacgcagcc ttggagccag cagcaagtaa tttgagtacg ccccgattgt 630241 aagacctaaa gcaagccata aggtggacag ccctgtcgca aacatcgcgc cgggaacacc 630301 catcagcatc catccgctca tatcggccgc gccggcagac aaagcagtaa cgaatggtcc 630361 gaggcctctt cctccaagca tgtaatcatt gatgtcagtg gttttcttga atgcatacca 630421 gccgattaac agcatggcaa taaagtaaat tcctaaagat ataataattt caatactcac 630481 gttttaccct ctcttcattt ctaataatgt tgcatcacct ctcaaattga tggtgccagt 630541 taagcagcct ggcgtaagtg caaaacaaaa gaaattcttt tgcgggtgca cttggtaact 630601 taacctaaca aagtattccc ggccattcaa gcgatgaaac attgatcata agctggaaat 630661 accgttgcaa acctagaagg gaataaagaa taaaacgctt tcaaaaaata attaaagtaa 630721 aaatattcag aaaaatattt cgtttctcct tctcctcatt ttagtataaa atatataggg 630781 tattgtttcg aaaacacagg cctgtctcaa ggcgttttgt tgctttaaag ggcttgtttt 630841 tgatatgatc agtattatat gacttaacgg agaaatatgt ggaggtggat catatgtcac 630901 gaatttcaat agaagaagta aagcacgttg cgcaccttgc aagacttgcg attactgaag 630961 aagaagcaaa aatgttcact gaacagctcg acagtatcat ttcatttgcc gaggagctta 631021 atgaggttaa cacagacaat gtggagccta caactcacgt gctgaaaatg aaaaatgtca 631081 tgagagaaga tgaagcgggt aaaggtcttc cggttgagga tgtcatgaaa aatgcgcctg 631141 accataaaga cggctatatt cgtgtgccat caattctgga ctaaaggagg gacacaagaa 631201 tgtcattatt tgatcataaa atcacagaat taaaacagct catacataaa aaagagatta 631261 agatttctga tctggttgat gaatcttata aacgcatcca agcggttgat gataaggtac 631321 aagccttttt ggcattagat gaagaaagag cgcgcgcata cgcgaaggag cttgatgagg 631381 cggttgacgg ccgttctgag cacggtcttc ttttcggtat gccgatcggc gtaaaagata 631441 atatcgtaac aaaagggctg cgcacaacat gctccagcaa aattctcgaa aactttgatc 631501 cgatttacga tgctactgtc gttcagcgcc ttcaagacgc tgaagcggtc acaatcggaa 631561 aactgaacat ggacgaattc gccatggggt catctacaga aaactcagct tacaagctga 631621 cgaaaaaccc ttggaacctg gatacagttc ccggcggttc aagcggcgga tctgcagctg 631681 cggttgctgc gggagaagtt ccgttttctc ttggatctga cacaggcggc tccatccgtc 631741 agccggcatc tttctgcggc gttgtcggat taaaacctac atacggacgt gtatctcgtt 631801 acggcctggt cgcatttgcg tcttcattgg accaaatcgg accgattaca cgtacggttg 631861 aggataacgc gtttttactt caagcgattt ccggcgtaga caaaatggac tctacgagtg 631921 caaatgtgga cgtgcctgat tttctttctt cattaactgg cgacatcaaa ggactgaaaa 631981 tcgccgttcc gaaagaatac cttggtgaag gtgtcggcaa agaagcgaga gaatctgtct 632041 tggcagcgct gaaagtcctt gaaggtctcg gcgctacatg ggaagaagtg tctcttccgc 632101 acagtaaata cgcgcttgcg acatattacc tgctgtcatc ttctgaagcg tcagcgaacc 632161 ttgcacgctt tgacggcatc cgctacggct accgcacaga caacgcggat aacctgatcg 632221 acctttacaa gcaaacgcgc gctgaaggtt tcggaaatga agtcaaacgc cgcatcatgc 632281 tcggaacgtt tgctttaagc tcaggctact acgatgcgta ctacaaaaaa gcgcaaaaag 632341 tgcgtacgtt gattaagaag gatttcgagg acgtatttga aaaatatgat gttattgttg 632401 gaccgactac accgacacct gcgtttaaaa tcggtgaaaa cacgaaggat ccgctcacaa 632461 tgtacgcaaa cgatatctta acgattccgg tcaaccttgc cggcgtaccg ggaatcagtg 632521 tgccatgcgg attagcagac ggacttccgc tcggcctgca aatcatcgga aaacactttg 632581 atgaaagcac tgtataccgc gttgctcatg catttgaaca agcaacagac catcataaag 632641 caaaacctga actgtaaggg gtgaaaagaa ttgaactttg aaacggtaat cggacttgaa 632701 gtccacgttg agttaaaaac aaaatcaaaa attttctcaa gctctccaac gccattcggc 632761 gcggaggcga atacgcagac aagcgttatt gacctcggat atccgggcgt cctgcctgtt 632821 ctgaacaaag aagccgttga attcgcaatg aaagccgcta tggcgctcaa ctgtgagatc 632881 gcaacggata cgaagtttga ccgcaaaaac tatttctatc ctgacaaccc gaaagcgtat 632941 cagatttctc aatttgataa gccaatcggc gaaaacggct ggatcgaaat tgaagtcggc 633001 ggcaaaacaa aacgcatcgg catcacgcgc cttcatcttg aagaggatgc cggaaaactg 633061 acgcatacgg gcgacggcta ttctcttgtt gacttcaacc gtcaaggaac gccgcttgtt 633121 gagatcgtat cagagccgga catccgcacg ccggaagaag cgtacgcata tcttgaaaag 633181 ctgaaatcca tcatccaata tacaggcgtt tctgactgta aaatggaaga aggctcactt 633241 cgctgtgacg ccaatatctc tcttcgtccg atcggccaag aggaattcgg cacaaaaaca 633301 gaattgaaaa acttgaactc ctttgcgttt gttcaaaaag gccttgagca tgaagaaaaa 633361 cgccaggagc aggttcttct ttccggcggc gtcatccagc aagaaactcg ccgttatgat 633421 gaagcaacga agaaaaccat tcttatgcgt gtcaaagagg gatctgacga ctaccgttac 633481 ttcccagagc cagatctagt cgagctctac attgatgatg aatggaagga acgcgtaaaa 633541 gcaagcattc ctgagcttcc ggatgagcgc cgcaagcgtt atatcgaaga gcttggcttg 633601 cctgcatatg acgcaatggt tctgacgctg acaaaagaaa tggctgattt cttcgaagaa 633661 accgttcaaa aaggcgctga agctaaacaa gcgtctaact ggctgatggg tgaagtgtca 633721 gcttacctaa acgcagaaca aaaagagctt gccgatgttg ccctgacacc tgaaggcctt 633781 gccggcatga tcaaattgat tgaaaaagga accatttctt ctaagatcgc gaagaaagtg 633841 tttaaagaat tgattgaaaa aggcggcgac gctgagaaga ttgtgaaaga gaaaggcctt 633901 gttcagattt ctgacgaagg cgtgcttctg aagcttgtca ctgaggcgct tgacaacaat 633961 cctcaatcaa tcgaagactt taaaaacgga aaagaccgcg cgatcggctt cctagtcgga 634021 cagattatga aagcgtccaa aggacaagcc aacccgccga tggtcaacaa aattctgctt 634081 gaagaaatta aaaaacgcta ataaaaaagc agcccttaga ggctgctttt tttatggtca 634141 aattgagata aagacaagat gagggcccga agcctttcaa cttctttgtc gttggttccg 634201 gccaaattgg acagcatgcc tttaataatc ggcttgcgcg gtttatcctg agtcaattct 634261 tcctcgataa catcaagtga cacggtgata tcctcgggca gcgtgctgtt ttctttcact 634321 ttctgaatgt cctcaagcag ctggtctttt cccgcaggca tcgggttaaa aatgtctttt 634381 gatacaatcg gattgagtgc agaacggctc agcccctgta caagatcatc cagtctctca 634441 ataataaagg ctgagatttc ttctgcatcg atattaagct caccgttaaa taccatcacg 634501 ttcatatagg aatgcacaat gcctcttgcc atgatggaca gatctgcgac ataccgctcg 634561 attccttcgc cataggatac cagcaaggcg ttccggtaca gcttatccgt ctccatggtt 634621 actttgtaaa agtattgctt gatttcttga ttttccggaa tgatattttc ggtaagcaaa 634681 agaacgataa aatctttatg atcgcgaaaa tcctcaaatt gagcgccaat ttgctttttt 634741 aacacttcct taggcggctt tccggcgaga tcttcttcta tatttttcat tttgttcata 634801 gacataccga tataatattc acaggcagat aacagcagcg cttctttcga tttgaagtgc 634861 aaataaaaag cgcccttcga aatgccgcat tcactggcga tttcttggat cgtcgtagct 634921 gcgaatcctt ttttcgcaaa taaacgaatg ctggttttta tgattctctc ttttttttca 634981 ttcatgacgt gcttcccctt aatccttgaa aaatttagta aaattttctg gtatatgagt 635041 tgacgttgtt gcgttataac gtttagtatt atatagaatg accagtcagt caataaaaaa 635101 tgtaatggag gatatgatga accacgttat taatttcgtt ctgaaaaaca aattcgccgt 635161 atggctgatg acgattattg taacggcagc cggcttgtat gcgggtatga atatgaagca 635221 agagtctatt cctgacgtga acatgcctta cttgacgatc agcacgacat atccgggtgc 635281 aacaccaagc caagtggctg atgaagtgac caaaccggtt gaacaagccg tacagaactt 635341 ggacggtgtc agcgttgtga cgtcgacgtc ctatgaaaac gcatcgtcgg tcatgattga 635401 atatgattat gagaaagata tggacaaagc gaaaacagaa gcagctgaag cgttagaaaa 635461 cgtcaacctg cctgatgacg cgaaggatcc ggagatttca cgctacagct tgaactcatt 635521 cccgattctg acgctgagcg tgtccagtga taaagataat ctgcaagagc tgacgaaaca 635581 agtggaggac agcctcgttt ctaagcttga aggcatagaa ggcgttgcgt ccgtccaagt 635641 atcaggccag caggtggaag aggttgaatt ctctttcaaa gaagacaaac tgaaggaata 635701 cggccttgat gaagatacag tcaagcaagt gattcaaggt tcagatgtga caactccgct 635761 tggattgtac acattcggaa atgaagaaaa atctgtcgtc gtcagcggcg atattgaaac 635821 aattaaagat ttgaagaata tgagaatccc gacggcatct gcttcaagtg caggcagcag 635881 cgcagcatct caagcaggtg cgcagagtgc tcaagcagcc caaagcgcgc aagcggcagc 635941 acaggtgcag caaagcgcaa gcacagcagt gccgacggtc aagctttctg acattgctac 636001 aattaaagat gtgaaaaaag ctgaatccgt ttcacgcaca aatggcaaag acagcatcgg 636061 catcaacatc gtcaaagcaa acgatgcgaa tacggtagag gttgccgacg atgtcaaagc 636121 tgagctgaaa aagttcaaag aagaccataa aggcttcaat tacagcgcaa ctctcgacat 636181 ggcggagccg atcacacagt cagttgacac gatgttaagc aaagccatct tcggtgctat 636241 ttttgcgatt gtgattattc tcttattctt aagagatatc aaatcaacat taatttctgt 636301 tgtttcaatt ccattatcat tgctgatcgc actccttgtg ctgcagcagc ttgatatcac 636361 attgaatatt atgacgctcg gcgcaatgac cgttgccatc ggacgtgtag tcgatgactc 636421 catcgttgtg atcgagaaca tttaccgccg catgagactc aaagatgagc cgctccgcgg 636481 aaaagccttg gttcgtgaag cgacgaagga aatgtttaaa ccgatcatgt catcaacgat 636541 tgtgacaatc gcggtattcc tgccgctcgc acttgtaggc ggacaaatcg gtgaattgtt 636601 tattccattt gccttaacga ttgtttttgc gcttgccgca tccctagtga tttcaatcac 636661 gcttgtgccg atgctcgcac acagcctgtt caaaaaatca ttaaccggtg cgccgattaa 636721 agcgaaagaa cacaaacctg gcagacttgc aaacatctat aaaaaagtat tgaactgggc 636781 gctgagccac aaatggatca cgtctatcat cgcggttctg atgctccttg gaagcttgtt 636841 cctcgtaccg ttaatcggtg ccagctacct gccgtccgag gaagaaaaaa cgatgcagct 636901 cacatacagc ccagaaccgg gtgaaacgaa aaaagaagcc gaaaatgaag ctgaaaaagc 636961 ggaaaaaatc ctgcttgacc gcaagcatgt cgatacggtt cagtattcat taggctctgg 637021 cagcccgctt gccggaggag attctaacgg tgcgttattc tatatcaaat atgaaagcga 637081 cacacctgac tttgataaag aaaaagataa cgttctgaag gaaatccaaa agcaatctga 637141 ccgcggagaa tggaagtcac aggacttcag ctcttcaggc aataataacg aattaacata 637201 ctatgtgtat ggcgattctg aaaacgatat taaagacacg gtcaaagaca ttgaaaaaat 637261 catgaaagat gaaaaggatc tgaaaaacgt aaattcaggc ctttccagca catatgatga 637321 gtacacattt gtcgctgacc aagaaaaact aagcaagctc ggtttaaccg cgtctcaaat 637381 ttctcaggcc ttaatgtcac aaacatcgca agaaccgctc accactgtga aaaaagacgg 637441 caaagagctt gatgtgaaca ttaagacaga aaaagacgag tataagagtg tgaaagattt 637501 agagaataaa aagatcactt ccgcgactgg ccaggaagtc aaaatcggcg atgtggcaaa 637561 agtgaaagaa ggatcaacat cagataccgt gtcaaaacgt gacggaaaag tctatgcaga 637621 tgtcacaggt gaggttacct ctgacaacgt cacagccgta tcagctgcta tccagaagaa 637681 aatcgataag cttgaccacc ctgataacgt atcgattgac acaggcggcg tatcagcgga 637741 tatcgctgat tccttcacga agctcggttt agcgatgctg gcagcaatag cgatcgttta 637801 ccttgtgctc gtgattacct tcggcggagc actagcgcca tttgcgattc tgttctcatt 637861 gccgttcaca gtcatcggtg ccctggtcgg actttacgta tcaggtgaaa cgatcagtct 637921 gaacgccatg atcggtatgc tcatgctgat cggtatcgtt gtcacgaatg ccattgtctt 637981 aattgaccgc gtgattcata aggaagcgga aggcctgtct acgagagaag cgctcctgga 638041 agccggctct acacgactcc gtccgatcct gatgacagcc attgcgacaa tcggcgcctt 638101 gattccatta gccctcggct tcgaaggcgg aagccaggtc atttcaaaag gactcggcgt 638161 aacggttatc ggcggtttaa tcagttcaac gcttctgacg ctcctgatcg tgccaatcgt 638221 atatgaagta ttggcgaagt tccgcaagaa aaaaccggga acggaagaag agtaaaaaac 638281 aaaaagcctc agctctgctg aggctttcag cttgttgaaa aaccctcgca ttcgttgtca 638341 ggtctgcgcg tcggtgctca cgaattctac attcgctccg ctccaatgct cccccttcct 638401 agactacaag ggttttcaat caagctgaaa gaatgttaag gatgacaaaa gctcaaaaca 638461 agaatcagtt ttgagctttt gtgcgttttc acctgtaaga ttatgtacat tttgttgcga 638521 tttttttaac tcatagtata attaaaggtt gttagtgtaa aaatggatcg gatactctta 638581 agtaggatga tgagataatg aaacgtgcac gcataatata caatccgact tcaggacggg 638641 agatctttaa aaagcatctt gcccaggtcc tgcaaaaatt tgaacaagcc ggctatgaaa 638701 cctccaccca tgcgacgaca tgcgcaggag acgctacaca cgctgccaag gaagcggcat 638761 tgcgtgagtt tgacctgatc attgcggcag gcggagacgg aacgatcaac gaggtcgtca 638821 acgggcttgc gcctttagac aatcgtccga cactcggtgt gattcctgtc ggcacaacga 638881 acgacttcgc cagagcgctc ggaatcccac gcgaggatat tttaaaagcg gcagatacgg 638941 tcattaacgg cgttgcccgc ccgattgata tcggacaggt caacggccag tattttatca 639001 atatcgccgg cggaggccgt ctgacggagc tgacgtacga cgtgccaagc aaactgaaaa 639061 caatgctcgg ccagcttgct tattatttaa aaggaatgga aatgctgcct tcacttcgtc 639121 cgacagaagt cgagattgaa tatgacggca agctgtttca aggtgaaatc atgctgtttt 639181 tggtcacgct gacaaactcc gtcggcgggt tcgaaaagct cgcgccggat tccagcctga 639241 atgacggcat gtttgatttg atgatactaa agaaagcaaa ccttgctgaa tttatcaggg 639301 tcgccacgat ggcgcttcgc ggagaacaca tcaacgacca gcacattatt tatacaaaag 639361 cgaaccgcgt gaaagtcaat gtatcagaaa agatgcagct gaacctggac ggcgagtacg 639421 gcggcatgct gccgggcgaa ttcgtgaatc tgtaccggca cattcacgtc gtcatgccga 639481 aggagaaagc ggaacagttg gatgactaaa acttggcttg gtaagccaag ctcagaatgt 639541 tgacaaaatc ctaaaacagt tttcgtttta ggattttgtc atcttttcag cgtgattgaa 639601 aacctttgaa gtctaggaag ggcgagcatc ggagcacagc gaatgttgaa ttcgtgagca 639661 ccgaagcaca ggcctgacaa cgaatgcgaa ggtttgccta cacgctgaaa cttggcttga 639721 ataggccaag tttttctttc gcttaaaact agaggtgatt atagatgaaa atgaaacccc 639781 cagtagaaaa aaatgaatac tacgatgtga catttgagga tttgacacat gaaggagcgg 639841 gcgtcgcaaa ggtccaaggc ttcccgatct ttgtgccgaa tgccctaccc gaggaaaaag 639901 cccaaatcaa agtgacacgc gtcaaaaaag ggttcgcctt cggccgcctg attgagctga 639961 aggaagaaag cccgcataga acggacgccc catgcccgat ttacaaacaa tgcggaggct 640021 gccagcttca gcacatgacc tacgaaggcc agctcctgtt taaacagaaa caagtcaaag 640081 acgtcttaga acgcatcggc aagctggacc tttcaaaagt caccgtgcac ccgacactcg 640141 gcatggaaga cccgtggaac tacagaaaca aagcacaggt gccggtagga gaacgggaag 640201 gcggactcgt cgcgggattc tatcagcaaa gaagccatga catcatcgac atgagcgcct 640261 gcctgatcca gcaatccaaa aacgacgaag ccgttcaagc tgtcaaagac atttgcgcaa 640321 actacggtgt caaagcctac aacgaagaac gccacaaagg ctggctccgc cacatcatgg 640381 tcagatacgg cgttgttacg ggcgaaatga tgatcgtctt catcacaaga acaagcgact 640441 tcccgcacaa agcgaagatc atcgaagaca tcacagcgca attcccgcac gtcaaatcca 640501 tcgtgcaaaa catcaaccca aacaaaacaa acgtcatttt tggcaacgaa acaaacgtca 640561 tctggggcga agaatacatc tacgacctca tcggagacgt caaattcgcc atctccgcca 640621 gatcgtttta tcaggtcaac ccagagcaaa caaaagtgct ctacgacaaa gcgcttgagt 640681 acgctgagct tcaaggggaa gaaaccgtca tcgacgctta ctgcggcatc ggaacgattt 640741 ctctcttcct ggcaaagcag gcgaaaaaag tgtacggtgt agagattgtg ccggaagcaa 640801 ttgaggacgc gaagcgaaac gccgaattaa acggcaacac aaacgcagag tttgctgttg 640861 gagaagcgga aaccgtgatt ccaaagtggt acgaagaagg cattacagct gatacgctgg 640921 tcgtcgaccc gccaagaaaa ggctgcgacg aagccctcct gcggacaatt gtggagatga 640981 agccgaagcg ggtagtgtat gtgtcctgta atcctggcac gcttgcgaga gatttgcggg 641041 tgcttgagga tggcgggtac gtgacgcgcg aagtgcagcc tgtggatatg tttccgcata 641101 cgaatcatgt ggagtgctgt gtgttgataa aattaaaaga ataaatagtc aaaaatctat 641161 gctgatggaa ctgttggttc tctaaaacga taattgattt caatggttcc atttgcatgt 641221 acttctattt catctactaa caaatgaagc atttcggggg taagtgtacc ttccttcatg 641281 aatttatcta agctcttttt aaaatcaatt atttcttttt caatcttttg aaattctagg 641341 tccttagata gttggtgaag ggtagtttca aaatttgaaa tatcttcatt ggtgatattt 641401 atggctaatt ggtaatcttc tttagatata acaccattag caagagagat aactaaattg 641461 gatttatctc tctttttatc gtttaatttt tcattaattt cgattatctt agattcgatt 641521 ttttctttgt actttaacgc tttttcactt aattctttaa aataattttc cttactgaat 641581 ttcaaatata tcttatttag gttggttatt actttatcag ttaaatctat ttcacttacg 641641 taatgatcac tacatgcttt taaaccatgt ttattataac ttccacaaac ataacctttt 641701 cgattctttt taaaatgcat tgacctcctg caatctttgc aaaccgcagt atttgtaaag 641761 agatgtactt cagcttgagg tctccttctt tttctagtta ttaaaatctc ttgtacaata 641821 agaaagtctt ctaaaggtat gattggttcg tggctttttt caataattat ttggttttct 641881 aggttaactg accttcttct tttactggta acactcggtc tatattctct acattgttgt 641941 agtgtcccag tatagtgagg attttcgaga atttttctta ttgaagatcc gtgccatttg 642001 tcagtagcgt tctttttgcg ggcaagctgc gagggactag tgaccccttc gttatacaat 642061 ccccttgcta ttgcatcaaa gccttttcca gcaatatatt ctgaaaagat tctaatattt 642121 actattttct ctgcgtttgc tgaatttgag agagatatga ttgtagaacg aactcaagaa 642181 ggtaaaatgt tggccaagca gaatccggat ttccgagaag gaagacccaa aaagttcaca 642241 aagcagcaaa tcaatcatgc attaacatta ctagaaaatc attcgtataa acaagttgaa 642301 gatatgactg ggatatcagt ttctacactt gtaagagcta aaaagaagaa agctgctgaa 642361 gctataaatg gataaatatt gtgaattaat tattcaatat cttgagaaat ttttataaaa 642421 gtaatcaaaa gtttaatggg ggaaacgaaa tggcgctcat tgatttagaa gataaaattg 642481 ctgaaatagt gaatcgagaa gatcattcag atttcttgta tgaattactc ggtgtatatg 642541 atgttccacg agctacaatt acgcgcttga aaaaaggaaa tcaaaacctt acaaaacggg 642601 ttggtgaagt acacttaaag aataaggtgt ggtttaagga ggctaagaaa ggaaagctct 642661 ttgacgccct tattgatata gaacaacaag ttgaatatct ttcagctaag ccacgatatt 642721 tattagttac tgactatgat ggagtattag cgaaagatac aaaaacatta gaggctcttg 642781 atgttaaatt tgaagaactt cctcagtatt tcgatttctt ccttgcttgg aaaggtattg 642841 agaaagtaga gtttgaaaag gaaaaccccg ctgatattaa agcagccgaa cgttttgcac 642901 ggatatatga tgtacttcgt aaagaaaaca atattattga gactaataga gggttagatt 642961 tatttcttat tcgtttactg ttttgttttt tcgcagaaga tactgacatc ttcaaacgaa 643021 atagttttac gaatttaatt aagactttga ctgaagaaga tggttcaaat ctaaataaat 643081 tatttgctga tttatttatc gtgttagata aaaatgaacg agacgatgtt ccatcttatt 643141 taaaagagtt tccgtatgta aatggccagt tgtttactga accacataca gagttggaat 643201 tttctgccaa atccagaaag ttaattattg agtgcggtga attattaaac tgggctaaaa 643261 tcaatcctga tatctttggt tcaatgattc aagctgttgc ttctgaagaa agccgtagtt 643321 atttaggtat gcactacaca agtgtcccca atataatgaa ggttattaaa ccgcttttcc 643381 tagataaact taatcagtct tttttagatg catacgatga ttatacaaaa cttgaaaatc 643441 ttctaacacg aatcggcaaa attaaattct ttgatcctgc atgtggttca gggaactttt 643501 tgattattac ctacaaagaa ttacggcgta tggaaatcaa tattataaaa cgacttcaag 643561 aactcttggg agagtatctt tatgtacctt cagtaacttt atctcaattt tacggaatag 643621 agattgaaga ttttgcacat gacgttgcaa aattatcact ttggattgct gaacatcaaa 643681 tgaatgaaga attaaaaaat gaagttcata atgcagtacg cccaacgtta ccacttcata 643741 cagcagggga tattcgttgt gcaaatgcta ttagggttga gtggactgag gtttgtcccg 643801 cacaaggatc tgaagaagta tatgtttttg gtaatccacc gtatcttggt tcaaaaaaac 643861 aaaacaaaga acataaatct gatatgttat caatttttgg aaaagtcaag aatggtaaaa 643921 tgcttgatta tatttctgct tggttttact ttggtgctaa atacgcttca actacaaatg 643981 caaaagttgc ctttgtatca acaaattcag ttactcaagg ggaacaggtt tctatcttat 644041 ggaatgagtt attcaagttt ggaattcaaa tcaattttgc ctataaatct tttaaatggg 644101 cgaataatgc taaaaataat gctgcggtaa ttgttgtgat tgtaggtttt ggcccgttag 644161 ataccaaagt aaacaagtat ttatttgttg atgaaacgaa aaagctagtt tctaacatta 644221 gtccctattt aactgatggt gaaaatattc ttgtttcttc taggacgaag ccaatttcag 644281 acttacccaa actgcatttt gggaacatgc ctaatgatgg cggaggatta ctctttacca 644341 ttacggaata tacagacgca atcaataagt atcctgaatt agttccctat tttaaaaagt 644401 ttataggttc agtagagttt attaatggtg gtttacggta ttgtttatgg cttaatgaag 644461 caaaatatga aaaaataaag tctaatcctc taatacaaga aagaatctca atttcaaaaa 644521 atcacaggga aaaatcaaca gataaaggaa cgaataaact tgcattaact ccgtggaagt 644581 ttagagatac tcatgaaaca actaattatt ccattgttgt tccatctgtg tcttctgaaa 644641 atagatttta tattccaatg ggattagcag gtgcagatac aattttgtca aatctaattt 644701 atgtaattta cgatgcagaa atttaccttc taggcatttt gatgtcacgg atgcatatga 644761 cttgggtaaa agctgtagcc ggaagattaa aaactgacta taggtactct gcaggtttat 644821 gttataacac tttccctatt cctgaattat caacaagaag gaagaatgaa attgaagaag 644881 caattcttga aattcttgat cttcgtgaag agcagggtgg tacattagca gagctttata 644941 acccttcaac aatgccaatt gaattaaaag tagcacatga aaagttggat ggaattgtag 645001 aaagagcgta tcgtcaaaaa caatttgaat ctgatgaaga acgcttagaa gtattgctta 645061 aattgtatca agaaatgaca gaacggtagg tgtaaggtgt atggaaaata taattgaaat 645121 taattataac caaactggta aaagtaagaa aacaaatgaa tacggtatgc gtgaaatgca 645181 ggcaagagct tttgaaaaac gtaactcaca atatctctta gttaaagcac cgccagcttc 645241 tgggaaatct agagctttaa tgtttatcgg tttggataag ctcataaatc aaggtttgag 645301 gaaagtgatt gttgctgtac ctgaacgctc tataggttct tcatttaaaa atacggattt 645361 aaaaagttat ggtttctttg aaaattggaa agttgatcct agaaataatt taactgttgg 645421 cggagataac tctaaggtta aatcttttgt tcgttttatg gaatcggacg atcaggtgtt 645481 aatatgtacg cactctactt tgcgatttgc gtttgaaaaa attgatgata aagcatttga 645541 taattgttta cttgcaatag atgaatttca ccatgtatcg gcagatgtca attctcgatt 645601 aggtgaattg ttaagaagta ttattcataa ttcatcagca catattgtag cgatgactgg 645661 gtcgtatttc cgtggagatt ctgtaccaat tttattacca gaagatgagg aattatttga 645721 caaggtaact tattcctatt atgaacaact tgatggatat gaatatctaa agggatttgg 645781 tataggatat cacttctatc aaggccagta cacatcagct attaatgaag tattggatac 645841 aaataagaaa acaatcgttc atattccaaa tgtaaactca ggggaatcga caaaggataa 645901 gtacgatgaa gttggtaaga tacttgatat gattggtgaa gttgaatatc aagatgatga 645961 tactggaatt atttatgtta agcgacattc tgacggtaaa acattgaaaa ttgcagattt 646021 agtagatgac caagttggaa gagaaaatgt cgttgcgtat ttgcgtaata ttgaagccct 646081 agacgattta gatataatta ttgctcttgg tatggcgaaa gagggctttg actggccgtt 646141 ttgtgaacat actttgacag ttggttatcg tggctcactt acagaaatag tacaaataat 646201 tgggcgctgt acacgtgata gttacaataa aacctatgct caatttacca acctaatcgc 646261 aatgcctgat gcaaaggatg aagtagtgac ttatacagtg aatacaatgc ttaaagctat 646321 ttctgcctca cttttgatgg agcaggtcct tacacctgac tttaaattta aacgtagaag 646381 aaatgaaagt gaaaaatctt ctactacagg agaattattc gttaagggat tgaaagaacc 646441 atcaacagaa aatgtcaaaa agattattga aaatgatatt aatgatttaa aagcaaaaat 646501 catgcaagat tcacaagtcc aaaaaacatt tagtggagaa gtagatccca aagtattgaa 646561 caaagtgttg attccgaaag ttattcaaaa agtatatcca aatttatcag atgaggaaat 646621 tgaggaagtt agacagcacg ttgttctaga tacagttatg aaaggtgcta agtctgaagt 646681 tgtaggaagt aaagaattta taagaatggc agataagttt ataaacattg aggatttaga 646741 tatcaatctg attgattcca tcaatccgtt ccaaaaagca tttgaggttc tatcgaaaga 646801 attgaactca ccagtgctaa aactgattca ggaaactatt gatgcaaaac gtattaattt 646861 tgatgaagat gaactagtat tcatatggcc aaaggtttag gaattttatc gttcaactgg 646921 tagaagacct gattcaaaat ctgaagaccc acttgaaagg cgtatgggtg aagctgtatt 646981 atacatgcaa gagcttagga ggaaacgtga aaatggcaag taatagatac cattctatta 647041 atgaaatcat ggaaagtcag ctgttttacc aaatcacaac accacctaag aaaacacaaa 647101 aagcccagta tgatcctgaa gttgaaaagt ttttggagat tattgaattc gtcaaagaaa 647161 atgggcgaga accccaaaaa gtccctactg atttaactga aagaagttta gcaagtcgat 647221 taattgggat tcggaaagat cctgatcgta tggaatattt gaaagagtat gatgaaattg 647281 gattacttga agtaagatcg aaggaactaa caattcctaa aatttcttca attgatgata 647341 ttctaaaaag tggcttatct gcattattag gtgataattt aaataatgat ataactaggt 647401 caatttttga tacaagttca cttcaaaagg ttacgacaat gcctgaatac gttgcaaagc 647461 gtaaaaaaat aaaagatttt ggaaagtttg aagagctatt caagaagtgc cacaaggaaa 647521 ttacagaggg taaacgaaaa attttaactt tcaaaaatga acaagacata cagtcaaata 647581 gtttttatat attaaaagga gttcttcttt atgttgaaga tgtgggagaa cgtaaaaaag 647641 caaagggaaa aaccaatgct agacttcgat gtatatttga aaatggaacg gaatcagata 647701 tgttactacg ttccttatca gcggagttat ataaacatgg tagacgtgtg accgacaatg 647761 aagatacatt gttggataat gttagagaag atgatgtttc gactggcttt atttacgtac 647821 taaaatcttt gagtacagat ccgcaaatta gttccattaa gaatttatat aagatcggtt 647881 ttacaactgg ttcagtagaa aatagaatca ggaatgcaga aaatcaatca acttatcttt 647941 atgctccagt agaaattgta accacatatc aagtgttcaa tatgaatgct agcaaatttg 648001 agacggcaat ccatcatgcg ctagcaaata ataatttgga tgtttctatt ttgggggcaa 648061 atggaaagat gttagttcct aaagagtggt tcgttgtcac acttgaagat ttacaagctg 648121 taatagatga gattgtgatg atggttcatc tttatgacta aattagtata ttaggatttt 648181 agtattaata ataattttat agtagactat gaaaaaattt gatgccataa caataacttg 648241 ttccgctttg gagtttgtca caattgtaga attatgtgtt gcgagtatta ataggaaggg 648301 gttgagcgac cgcaaaaaaa attttcggtg ctgtccgcaa aagggagttt gggtgttttg 648361 cgttatattt ggttgtgtga aggttagcgg aaactcaatt cgtgaagtta ggattgcggt 648421 tattacgact gagtagtttc gtcatactct tttagcagtt tttctgtctt atgcatttct 648481 ttgagcatcg gattcatgta gtcgttagct gattctagat atgctctcgt cagagtgtct 648541 agtttatttc taactttaga gaggtcttct tcgaattttc catccgatga ttgaaggata 648601 aattcttttg cctcttcata tctttttaat atgtttttca ccattggagt tggattcttt 648661 tgatttattg tttttattac agtgattgtt aaatttattt gttttattaa ttcttttctt 648721 actgtcaagg tgatgctcct tttaaatctc tattctattt gagagttgct atatctgttt 648781 aatggtttga tagactactc atctttataa tttagagcaa tttttacaac ttgttccgct 648841 gtgtaatctt cattgctcca gaaaattaaa tcacttggtg ccggataagg aacatttttc 648901 tctaataaat cgagatattc actgactttc tcatcatcta atgttgggtt cattaattcc 648961 tttacaagaa agatcaactc ttcttttgtc agtttatcca ttgtttgccc tccaatagat 649021 tgtatctcca ttgattttac aaatgacttt atttcttctg ataatgttat aggttgtttg 649081 cataatgata gataattgtc ttgagaaaag ttagtctcat tatagagttt attaattgta 649141 tttataacaa tatattcata tggaaaacct ctaaaatatc tttattttag attggtttat 649201 aaaaaatagc tcagcagagt agggctgagc cattttttaa ttatagaccg aggtaactaa 649261 ttacaaattc tttatcatcc tcatcttcag gcaaaatacc aaggttttta tattcccata 649321 ttgcgattct ttcatatcca tctaattctg aggctaaaat atcatcataa ttataatcta 649381 attggaattc tccgctacga tccaatgtta gtgtaaggtt agtccaaaca tcatcgttat 649441 tatttctgtg ttcagttctt aattcttcaa aaagttctct tagttctctt aacaacgtct 649501 tgaaaatatc cttgcttacg ttgtaatggc taggtatatc ttgtgaataa ataatttgat 649561 tattttctgg tgttctgaaa tgaaaaagaa ccattgtgga atcatctaat acttctgcat 649621 aaagatatat ctttgtccat tcaccaggta tgatgtcatt gagtttttct ccaataagtt 649681 gatacaaatc ttgcatcttc ctagtttcca ttcttctaac ccccaggctg atttttaata 649741 gagacgctta tttcttttct gctcccaatt ttgtaggtta catcgaaata tgatggtcta 649801 agtgaatccc cagaatagac tggttctatt tgaactgcta cttttttagg tggttttttg 649861 cttagggctt ttgcccactc ctgctccatc tcataccatt tcccaccgct cctattaatc 649921 tgagaattca tcggcacgat attgtcaaac tggcctgagc ctttgaattg ggtggcgatt 649981 aaatggccgc cgtcatcgtc aggctttcgg tcctggggct ttccagcatt cgtttgtgca 650041 tattggtttc gtttcgcttc tcccagctgc aagtctgctt tgacacttgt aattctacca 650101 tagttgtcag tcgtgtacgt gtagccttct tttgttttgt agatgatatt aggcttcagc 650161 actttctttc tgctccatct tgcgaaatgc tcgccgtatt tgacggttac cggcggtaca 650221 tgtggcgctg gagttcgtct tccgcttgat gacgttccgt atggtttcgg caggatgacc 650281 ttggcgaatt tttgcagtcc ttctttaagc gtgaccccgt tgactgcgtt gtaaggaacg 650341 cctgccggca ctaaatcatg acggggatga tacgggagaa tatccgcaag tgtgagatct 650401 ccgatttgat ttaacttggt tttgacgtgt ttttttgata cttcaatgcc tgtgtttact 650461 ttttgtttga tgtgatcaac ggtttgtttt gagactgtta tggctttttg ggctgttgct 650521 gatttgcttg ctgctgtttt gactttggtc gtcactttgg cggctgtgcc agtttttgag 650581 acggctccta cgccttttgt gccgacaatt gatgtgacaa cagtgccaac cgcatatgac 650641 acccatcttg ctcttgagta ggtgtcacca ttcaccatgt ctttttgata cgattcttcg 650701 attgccgctg aaatggcttc atacgttttg atcgggtgag ccatcgctcc ggtaatcgct 650761 tcaacggttc ctcccggatc tgtgaccata tcccacaggc ctacgaccgc gtctttcccg 650821 gaatcataaa ggccgacggc aacccctttg aagcctgctt caagctcacg cgtgttttca 650881 atttgggtga agtatctctg ttgttcagct gtcagatttt catagccgat cgtttttgcc 650941 atttcgtaga attcatcggc atctgcataa tcgtagtttt tcagtctttc tttcagtttc 651001 tcaatctcgc gttccttcgc ttcctctttc ttaatcttca agtaagcctc agtccgcttt 651061 tcaatgtcgc cttttttctt atgtatgtca ctctcacggt acgccttggc gttgtagtgg 651121 atgggtgtgg cgtttttgcc tttacccgtt gcttcttgga gcttttggaa gtcggatttg 651181 atgaattgtt cgtttggttc agacagggcg tattctgttt tcaggtcttc gtccaaggcg 651241 tccaattttt ccagtgtttt tttgcgtttg tcgttggcat cggccagctc gtctttgaag 651301 gtttctgttg aaaacaggtc gagcgggagg atgtcgtcga tatcgtttag gatgtctttc 651361 atcgcttttt tctgttcgga catgatggat ttagattttt tattggcatt tgccagttcg 651421 tgctccagga aggattcttc gatgtatgcg tctgagaggc ctttgtcttc ggcggctccg 651481 gcgatgctgt tgaaaaatgc gattttcatg tcgatgtagt cgatccactg gtcggcgacg 651541 ccgacgtggt cgtgatagaa tgccttgatg ttgctggcgc cttttcctga gaattcactg 651601 tcactgagat cagcgactcc ttttaacgct tttctcaagt tgaccatttg cgttcttagt 651661 tctttgtact cttttgcacg gtctgtcgct tccgaaagca gtgttttcgc ttcaaatact 651721 ttcatgacca tttcccttct tttgttcgct caatatcaaa attttaccac gggtcgggat 651781 aaggtggggg tgagaacgtg ttttggtgga aaaatgagtc atttggcatg tgtctttatt 651841 cgtggaggga ttggaggaaa catggtcgaa atgatattga ttgctacaca ttttttggaa 651901 gtttgtattc tatattgttt tttaaggagc atgttgatga cgaaaaaacg gattacattt 651961 ggtttattag ttttaatggt atgtgtcatc ctgtttgttc tgtatgttca gttacgcaat 652021 aaagatagta ttcctgtcca atcttccgcc attcaccccg aagaagaccg catctttttt 652081 atttactcca atcctttcat aaaagaaagc gtgctgcttt caacctctac aggcgaacgg 652141 tttaacaggc gtacgtttaa ggtggcggat gtgccttata ttcaaacgaa atcttatgca 652201 tcaacagacc ttgtattatt ggcggaacac gagccttttt actacacgct ggagaaggat 652261 gtgatcaaag agcatccgct gtcagatcca tttgcgtttt ggtatgaggg gaaggatgtc 652321 actattgagg cctataatgt tgatacgacg ggaaatgaga tccacataaa cgacagaaaa 652381 acgaaaaagg aatataccct taccttgcct ccgcttgtca caatgggggc cagtgatgag 652441 aactttattt atatcattca aagcatgtct atttacgtga ttgacagaaa aacagaggaa 652501 atgattgaga ccctgagctt agcctcatac gctgatcaat tcgcagactc ggaggaattt 652561 atcgtcgcga gctcggatca taaattgact gtgattgaaa aagggacatg gaagacgaca 652621 tatattgcgt atcctgaaga tcttgaatat gcagatactg tgtactatga caaagaaagc 652681 ggcagttttt acgtggcgta cgaggacaaa gagggtggag cgaacttgct ggaatatggg 652741 gaggattttt ctattcacac atacagcttg aaattccctt atatggaggc gaagtttaag 652801 gggaatctat tgtatatagt tgcccaggaa gagcataaaa agggcatcgg cggatacgtg 652861 ggtgtgtttg atatccattc taaggagatg ctttatcagt ttgatttgcc tgaggaacag 652921 gtgaaggttc aggattttgt tgtggttgac aataagtgaa tactatatga aatagaatga 652981 caaagaccct tgcataaagg gttctttttt atgaaaaaaa caaattgaca ggatgaaaaa 653041 acaatttctt ccttctatat tgttttcaaa atttgggatt gatagaatat gacatatctc 653101 atagagaagg agggaagccg ttgagtcaag ccataccgtc ttcgcgtgtt ggtgttaaga 653161 ttaatgaatg gtataaaatg attcgccagt tcagtgttcc ggatgctgag attctgaaag 653221 cggaggttga gcaggacatt cagcagatgg aagaagatca ggatttactg atctattatt 653281 ctctgatgtg ttttcggcac cagctgatgc ttgattattt ggagccggga aaaacatacg 653341 ggaatcgccc tacagtgaca gagcttcttg aaacgatcga gacccctcag aaaaaactca 653401 caggtctttt gaaatactac tctttgtttt tccgcggcat gtatgaattt gaccaaaaag 653461 aatatgtgga agcgatcgga tattatcgcg aggcggagaa agaactgccg tttgtgtcag 653521 atgatattga gaaagcggaa ttccatttta aagtggcaga agcgtattat cacatgaagc 653581 aaacccatgt gtcgatgtat catattcttc aagccttgga catttatcaa aaccatcctc 653641 tatacagcat tagaacgata caaagcttgt ttgtgatcgc cggcaactat gatgatttca 653701 aacattatga taaagcgctc ccgcatttag aggcggcgct ggaattggca atggacattc 653761 aaaatgacag gtttatcgcc atttctctat tgaacattgc aaacagctat gacagatcag 653821 gagacgatca gatggctgta gaacatttcc aaaaagcggc gaaagtaagc agagagaaag 653881 tgcctgatct gcttccgaaa gtcttgtttg gattaagctg gacattatgt aaagcgggcc 653941 aaacacagaa ggcgtttcag ttcatagagg aaggattaga ccatatcaca gcacgttctc 654001 acaaatttta taaagaattg tttctgttct tgcaggccgt gtacaaggag actgttgatg 654061 aacgaaaaat tcatgatctt ttaagctatt tcgaaaaaaa gaacctgcac gcttacattg 654121 aagcatgtgc ccggagtgct gccgctgttt ttgaaagcag ctgtcacttt gaacaagcag 654181 ctgcgtttta tcggaaagtg ctgaaagccc aagaagatat tctaaaagga gagtgtttat 654241 atgcctatta agaaaaaagt gatgatgtgt ctggctgtta ctctagtttt cggaagcatg 654301 tcgtttccaa ccctgacaaa ctccggtgga tttaaggaat cgacagatcg aaatacgacg 654361 tatatcgatc attcccctta caaacttagt gatcagaaga aagcccttag ctagggcttt 654421 ttcttgcttt acggaagacg ttccattttc cacatcgcgg cattccttct atttctaacg 654481 caagacactc gaaacaacca aaccatttga ggtataatgg ataaagtgaa taacagtatt 654541 tagattgata tatatgaaag agagtggaac atcatgggcc gtaagtggaa caatattaaa 654601 gagaagaagg cgtctaagga cgcaaatacg agtcggattt atgcgaagtt tggccgtgag 654661 atttatgtgg cggcgaaaca gggcgagcct gatccggaat ccaaccaggc gctgaaggtt 654721 gtgcttgaac gtgcgaagac ttacagcgtg ccgaaaaaca tcattgaacg tgcgatcgag 654781 aaggcgaagg gcggagcgga agagaattac gatgagcttc gttatgaggg cttcgggccg 654841 aacggatcaa tgattatcgt tgatgcgctg acgaataatg taaaccgtac ggcgccggaa 654901 gtgcgtgcgg cgttcgggaa aaacggcgga aacatgggtg tgagcggatc tgttgcttac 654961 atgtttgacg cgacggctgt aatcggtgtg gaaggcaaaa cggctgacga agcgcttgaa 655021 atcctgatgg aagcggatgt tgatgtacgt gacattttag aagaggatga cagcgcgatc 655081 gtgtatgccg agcctgatca attccatgcg gtgcaagagg cgtttaaaaa cgcgggtgtc 655141 gaggaattta cagtagcgga gctgacaatg cttgcgcaaa gtgaagtaac gcttccggat 655201 gatgcaaagg aacagtttga aaaattgatt gatgcattag aagatttgga agatgttcag 655261 caggtatatc ataacgttga tttaggtgag taaggagtga gcaggctgtt atggcctgct 655321 ttttttgtcc cggaaattgt tttagctgta tgtaggcggc cgcctatacg atctataaga 655381 tattctcata ctctggactg taacctatgt gaaggagaga gtaaatatga ctgatacaag 655441 acatatgtat ggcggacctg gttttggtca ttatcagggc tttggtattg gccacccggg 655501 ctatggcatg caaagcacag gctatccggg ctatggcatg tatggaggcc acccgggcta 655561 tggcatgcaa ggctacccag atcacggcat acatggagga gtcggcggct atccgggata 655621 tggtgggtac ggcggttacc caagcggcgg ctatggaggc tctccgggaa ctggaagcta 655681 tccgagcatg caccatgaaa atgatggcca tcaccactat tatcaccatc atcatgatgg 655741 aaaagataat cttcatcacc atcatcacca tgttggaaag gataatcatc accaccatca 655801 tgatggtcat tatggccacc atcatcacca tatgggccac tggggaaaag acggttataa 655861 ataaagaaga tgatgataaa aagaggacac tcttgcagat caagagtgtt tttttagctt 655921 ttttcttgac tgttcagtct ggaaaatggt aacatttgtt tcaggaggtg atcatttttt 655981 ggggaggaat aaagaatttg atacggcgct tgttcttcac agggcgatag aggtttttgg 656041 agagtatggc tacgaaggaa cgtctcttca ggatctgctc tctcatttag gcattgcgcg 656101 ccaaagtttg tatgatacgt atggaacgaa gcgtgatttg tttttgtccg ctgtgaaatc 656161 gtatcttgaa gggaaaaacg ctgccgttat ggaaaggctt gaagcgccag gatctgtaaa 656221 ggaagccatt cgtgatattt ttcaggaggg tgtcaatgcc ctgagggatc cggaacgggc 656281 gaaggcgtgc tacattatta acagcgcgat tgaacagatc ccgcatgacc ctgagcttgc 656341 ccggtatttt gaaagacaat ccaagcagct tgaggacgct ttttatcacg ggcttttaag 656401 agcgaaggat caaggagaat tgaatggcga agatactgat atatctgcgc ttgctcggta 656461 cctgaatcag agcaggctgt cactgacatt tattgcaaaa gtgacggcag atatggatcg 656521 gcttcaggac catgttgacg tgagtttatc agtgcttgat taacatgtgg taaaggattc 656581 tttgcccatg tatgtacttt ttggactgaa tagtctagaa ataaaaatga ggtgatgatg 656641 aatgttgatg aatgagtttg aaaaagcatg tgaaacattg agaaagttta tggcttatat 656701 gcttgagaag gacatgaaga gctggacgga gctttgggat gagaatgctg tatttgagtt 656761 tccttatgcg ccggagggat caccaaaaag aatagaagga aaagcggcca tttacgatta 656821 tattaaagat tatcctaagc agattcatct ttcttcattt accgctccga cagtgtaccg 656881 ttcagcagac tcgaatacgg tgattgcgga gtttcaatgt gacggccatg tgattgagac 656941 tggactgcct tatcgccaaa gctatatcag tgtcatcgaa acgagagacg gccgcattgt 657001 gcgttatagg gattattgga atccgcttgt tgtaaaagag gcctttggag gatcattttt 657061 gcaaacagag gagagtggga aatgatgaaa cagaatccga ttttaatcac gggcgggacc 657121 ggcacagtcg gcagccgaat cgccagccgt ttaataaagc tgggatacag agtgcgtatt 657181 gcaagccgga aaaagggcgc gcttgctgat gctgagtatg tgtattttaa ttggaagtac 657241 gcctccagtt ttacgcctgc tctggaacag gtaaaacaga tctatcttgt tgctccggtc 657301 ggtgtatttg atccggctcc ctatgtgctt ccctttttaa aggaagcaaa gcgtctcggc 657361 gcaaagcggg tagtgatgca aagtgcgtct gttgtctccg agaacggtcc cgtgtttggc 657421 gcgcttcacc aggcagtgcg cgagtttcca gaatggacgg tgctgcggcc ctcatacttt 657481 atgcaaaatt tcatcaatgt ccagcaccgc atgtctattc aaacggaggg gcgcatcaca 657541 acggcttcgg gtgaaggaaa acttgggttt attgacgctg atgacatcgc agaaacagcc 657601 gtcagggctt tgattgatga tgttcctcat caaacacatc atattctgac aggtcccgag 657661 gcgctgagct atgccgaagc ggcggagatc attggagctg cggcgggacg ccgggtggag 657721 catgtcagca tttctcgttc cgagctgcag cataaaatgg aggcaggagg tttgcccgcg 657781 gattatgccc attttatggc gaagcttgat gaggcaatta gccatggtgc ggaacatcgg 657841 gtaacggata cagtgaagcg tgtgacggga aaagaacctc gttcgctgtc agagtttgcg 657901 gctgctcatg ctgcatattg gacctcattt tggactgaat agtctagaaa gaccttcggc 657961 gcttccgaag gtcttcttat tgaaaaagct aagtcgtgtt ttagtcataa tcatgcctcc 658021 tgcctcatac ctattaaggt cattgttttt gagaaaggag gagccggaat gaaggatatg 658081 cagccgttta cgcctgtcaa atcatatacg ccctttcaca gccgttttga tccctgtccg 658141 cccataggga agaaatatta cagaacgccc cctaaccttt atatgacctt tcagcctgag 658201 cacatggagc agttttcgcc gatggaggct ttgaggaaag gcaccctttg gaaggatctc 658261 tatgattttt atgaaaaccc ttatcgaggg ggagacgcac atggcaaaaa aggttgacgc 658321 cgaatattat cgtcagctag agcaaataca ggctgctgat tttgtgcttg ttgagctgag 658381 tctttattta aatacacatc ctcatgatga agatgcgttg aagcaattca atcaatattc 658441 cggctattca aggcacttaa aaagacagtt cgaatcctct tacggaccgc ttctgcagtt 658501 cggcaacagc cccgcgggca aggattggga ttggggaaaa gggccatggc cgtggcaagt 658561 ataaggagga atgcctgaat gtgggtgtat gaaaagaagc tgcaataccc tgtcaaggtc 658621 agtacgtgca acccgacgct ggcgaagtat ttgattgagc agtatggcgg agcggacggc 658681 gagctggccg cggctctccg gtatttgaac cagcgttata cgattcctga taaggtcatc 658741 ggccttttaa cagatatcgg cacggaggag tttgcccatt tggaaatgat tgcgaccatg 658801 gtctataagt taacgaaaga cgccacaccg gagcagctgc gtgaagctgg gcttggcgat 658861 cattacgtca atcacgacag cgcgcttttt tatcataatg cggcgggcgt gccgtttacc 658921 gcgagctata tccaagcgaa gggcgatccg attgccgatt tatacgaaga tattgccgca 658981 gaagaaaagg cgcgggcgac gtatcaatgg ctgattgata tttcggatga tcctgattta 659041 aacgattccc tgcgtttttt gcgtgagcgt gaaatcgtac actctatgcg cttcagagaa 659101 gcggttgaaa ttttaaaaga agaacgggat aaaaagaaga ttttctaata ggcagattgg 659161 cctctctttc atacaccctt ttacatacag agaaaatggt ctgtttttgc agtttggtct 659221 gcattataat caaggtgtgt gtgcaagctt actttttgat tgggaggcct ttatgacagc 659281 ttttaagatt gagaacgaaa cgattgcaga tggattttac gcgtgtccgg ccgtctatga 659341 ggatgcagaa tcgattaccg ggttgctcgt ccgaacagct gaatggctcc gggatcgggg 659401 ttctaaccaa tggagcggac ttctcaaagg gcaagatata catgatatca cggggtcaat 659461 tgaaaaggga catgtgtttg tgtttaaaaa agatgaagag cttgcggctg tcgtgatgct 659521 gctgcctgca ccgagcgagt gggaccggac gctttgggga gacgatgggc atgaggagtc 659581 catttattta caccgcctcg cagtaagccg ccggtttgcg ggacaggggc ttggagcccg 659641 cgtccttcag tgggcggaga cgggcataca ctttccggaa aaaacgcgga tccggcttga 659701 ctgtgtcgct gatagtgacg ccctgcattc cttttatcgg cgtatgggat atgaattcat 659761 gggtgctgat gcgtccggat atcatttgtt tgagaaagag attacggcag aataagcgtc 659821 ctttgcaggg ggcttttttg tctttttcta aaagggaggc aggcgatgtg tggtcaatat 659881 tatttgtgac agggattgtg acggcttgtc tgtttgctgg cgtatccgta ttgatgcgga 659941 tgagatttcc tgacaaaagt cggccggaat ggatgttggc cgggctgatc gtccttggtg 660001 tgtttgcgat ctggtacagc ctcgtgtatg tacgcggctg ggaaggggct gcgctcggaa 660061 tgcttggatt caatgtcatt ttcggagcca ttgccggata tttgatcgat aaggccatcc 660121 ggcgttacag gaaaagataa ggctgctgcc gtctctcaac aggtcgaaat tttcacagac 660181 cggcaggaat tttctttcga aaggagaaat acatattact ttaaaatgaa agcgttttcc 660241 aaagcaggaa ggtgatgttg atgatacaca gtgtggcaaa tgggctgaat catttttgta 660301 cgtgggtgat gagactggcc tatttgaatg tgctttggat tttgttttct cttgcaggcc 660361 tggttgtatt tgggctgatg cccgctactg ccgcgatgtt tacagtggcg agagaatggg 660421 cgaaggggaa tacagatgcc ccggtgtttt ctgtcttttt tcggacgttt aaaaaggaat 660481 ggcgggcatc acagatcctc gggcttatcg ttgtgacggc tgccctgttt ctgtttgcgg 660541 atatgcggat agcggctcag atggaccagc ctgtgctcgt caatgtattc gtgagcatta 660601 gtttgatttt cgcgtttgtt gtgctgtatg tgttcccggt attttctcat tttgacgtaa 660661 aaatcagaga ggtgctgagc atcagctttt tcattgcctt cagtcgtccg gcggtgacgc 660721 ttttgatggc agcgggcgct gtcggtgtgc tttgtctcgt tctgtttcat gtcacgtttc 660781 tattgttttt cagcgggagt ttactcagcc tgatcttaac gaagctgtcc tttaaagcgt 660841 ttcggtcaat ggatcagcgg caggagaaag aaaaggcggc atgaagaaaa gagttgctgg 660901 ctggtacagg cggatgaaga ttaaggataa gctgtttgtg tttctatcgt tgattatggc 660961 cgtatccttt ctgtttgtat acagcggggt ccagtatgcc tttcatgtgt atgatgagca 661021 gatttaccgc aagtcctcgg aggtgcttcg gatgtcttct gaaaggatcg aagacgagct 661081 gaagaagata gaggatgtgt catatgaaat cattacagac gaacagattc agcgcatcct 661141 gagcatgcaa aatcgggatg atacgtatga tcaatatcaa atgaagcagg agctgtggga 661201 tcagcttgcg ggatatgcca gcgatgaaaa gtacatcgat tccattcatg tgattgatgc 661261 ccgcggctca gagtattcag ccggaagcag ttcttcagat cttttgcagc aggagcagga 661321 agaggtattt aagcgagcga aagcgaaaag tggaagaaat ctttggatga cgctcggcgg 661381 gtcagacccc gtcctgattt cagcacggca gatcaggtcc tatcaccagc tgagtctgaa 661441 cggcttgggc atggtactga tccaggtcaa tgtaaaacag atgattcgtg atgtgccgaa 661501 ggattggggc gattcagtcg gagacattat gattgctgac caaggcggta atttggtgta 661561 tacggcacat gcatcagcgc atgttcctga ggcagcaaaa gagacgttga agcaccccgg 661621 ttatgacttg ataaaaaaga atggcaaacg ttactttatt tcttatcttc aatcatccta 661681 ccaaaattgg agctactata acgttatccc ctttgatcag atgttcgcaa aaatttcctt 661741 tatgaaaaca gtgatcggca catgctttct tctctttttc tgtgtggttt tgcttttcgg 661801 aaggaaaatc gccaacagca tcacggagcc gattgaacag cttgtgaccg cgatgaaatc 661861 ggtacagcac agcggcattg aagcaggtgt gtcgctttct ctgccggaac atacacagga 661921 tgaggccggc atgctgaacc gccattttac tgtcatgatg aaacggatta atgagctgat 661981 ggaagaaaat gtggaaaaac agctcatcat taaagaaacc gaattgaaag cactgcaagc 662041 ccagatcaat ccgcattttt tatataacac gctcgagtcc atcaattggc tggccaaggc 662101 gaatcagcaa aagcaaatct caaaaatggt ggaatcgctc ggttttcttc tgcgaaacag 662161 catacatatg aagaaggata tcgtgaccat tcaggaggag gcggacattg tacgtcacta 662221 tatgaccatt cagcgatttc gatttgaaga gcgcctgaaa ttcacgttgg atattgacga 662281 tgaggtgaag cattgcctca ttccgaaact gacgctccag ccgcttgcgg aaaatgcgat 662341 tcaatacgcg cttgaaccct ttacaaggcc atgcgccatc cggattcagg cgaaaaaggc 662401 gaagggctgt gtctgtatta cggtcgaaga taacggccct ggcatggatg gacggattct 662461 tgaatcaacg ggtggaagag gaatcggact ttggaatatt cgcgagcgca tcagcctgac 662521 attcggagag ccatacggat tgcggattca tagtgagcat gaaaagggga cgaggattgt 662581 gatcacaata ccgtgccgaa atgaggtggt gtgatgtata aaatactgct ggctgatgat 662641 gagaggatta tccttgatgg aatggcggga atcattgagt gggagtcgct tggcgcctca 662701 ttgatcggaa aagcgcagaa cggacatgaa gcatatgaaa agattgtaca taagcagccg 662761 catatcgtca tcacagacgt caaaatgccc ggcatggacg ggcttgagct gatcaaaaag 662821 gtgtcagccg tcagcccgtc ggtgcaattt atcgtcctgt ccgggtttgg agagtttgag 662881 tacgcaaagg aagccatgaa atatggggtg aagcattatt tgctgaaacc ctgcaatgaa 662941 cagcagatta tcagctcgct ggaggaaatc attgctgagc tgaagcggca agatgtgcac 663001 aaaaagaaaa cagcccatct gaaacacgag ctggaccata tccgttcctt tgcagccgat 663061 caatacttgg aaggcttgat cgccggtgtg gcccagcttt ctccgccgcc ttcacttgcc 663121 ggaaaaaaga tccgcctctt gatcttaaaa ggggaacaat ctattgatgc tgcagccaga 663181 gaggcactcg gatcggcact gacagcggtt tgcagcagcg gtgaatggac cgtgctcgcc 663241 gtagaggaga acgccgctga aaaggtggcg gaggtttttg cggaccgcaa gatggccatc 663301 agtcaggcgg gagaactccg gcacgcgggg cagctgtttc gtgacacagc tgaagcgtct 663361 ggtgacctgc atgggagcgc agtgatttca aaaatgatca ggcttattgc cgacgagctc 663421 ggaaatccga atctgtcctt aaaatgggcg gcgaaggata tgctgtttat gaatcctgat 663481 tatctcggga agttatttaa gcaggaaaca ggcgagaaat tttcccaata tgttacacgg 663541 gtgcgtcttg agcatgcgat gaagcagatg aaaataagga gggacgtgag cgtttcagaa 663601 attgctgaag aaatcgggtt tggcgataat ccgaagtatt tcagtcttgt ttttaaaaaa 663661 tataccggtc tgacaccgtc agaattcaga agaaaacagg gaggcgcttc cgcaggatag 663721 ccatctctgt ttttttgact ttcgccactg ttttttgagt gtttcgccct atccgaacgc 663781 tttaaaataa aatgtaagca cttacattaa aggggggatt ggtttgaaga agatttgtta 663841 cgtgctgtta tcccttgtct gcgtcttttt gttcagcgga tgttcagcgg gtgaagaggc 663901 ctcgggaaaa aaagaagatg ttacactcag aatcgcgtgg tggggcgggc agccaaggca 663961 tgattataca actaaggtaa ttgaactata cgagaaaaag aatccgcacg tccatattga 664021 agcggaattt gcgaactggg atgactactg gaaaaagctt gcgcccatgt ctgccgccgg 664081 ccagcttcct gatgtcattc aaatggatac cgcttactta gcccaatacg gaaagaagaa 664141 ccagctggaa gatttaacgc cgtatacaaa ggatggaacg attgacgtca gttcaatcga 664201 cgagaatatg ctgtcgggcg gaaaaatcga caataagctt tatggattta cgctaggtgt 664261 caacgtgctg tctgtgattg ccaatgaaga tttgctgaaa aaagccggtg tgtctatcaa 664321 tcaggaaaac tggacgtggg aggattacga gaagctggcg tatgatcttc aggaaaaagc 664381 cggtgtctac ggttccaacg gaatgcatcc gcctgatatt ttcttccctt attatttgcg 664441 cacaaagggt gagcgctttt ataaagaaga cggcactggc ctcgcgtatc aagatgatca 664501 gctgtttgtc gattactttg aacggcagct gaggctagtg aaagcgaaaa cgtccccaac 664561 acctgatgaa agcgcacaga ttaaagggat ggaagacgat tttatcgtca aaggcaaatc 664621 agcgattaca tggaactact ccaatcaata tttgggcttt gcccggctga cagactcgcc 664681 gctgtctctc tatctgccgc cggagcaaat gcaggaaaag gcgctgacac tgaagcccag 664741 tatgctgttt tccattccga aaagctctga gcataaaaaa gaggcagcga aatttattaa 664801 tttcttcgtg aataatgagg aagcgaacca gctgattaaa ggcgagcgag gcgttccagt 664861 ctccgacaag gtggcggatg cgattaaacc gaagctgaat gaggaagaaa ccaacatcgt 664921 ggagtatgta gaaaccgcgt caaaaaacat cagcaaagcc gatccgccag agcctgtggg 664981 aagcgcggag gtcatcaagc tgctgaaaga tacgtcagat cagattctgt atcagaaggt 665041 atcgccggaa aaagccgcca aaacgttccg gaaaaaggcc aatgagatat tagagaggaa 665101 taattgacgg gaaatggggc tgacgcaatg aaaaaaagcc ggagtataag aaaagacaat 665161 ctggcgggat atgcttttat ttctccgttt atcatcgggt tcctatgctt tacggtgatt 665221 ccgatggggg cgtccctgtt tctgtccttc acgagctatg acttgtttac ggcgccgaaa 665281 tggatcgggc tcgacaactt taaggaaatg tttacgggtg acgaaaagta ttggcagtct 665341 ctgaaggtga cgtttacgta tgtgcttgcc ggggttccgc tccgcctcgg cttcgcgctt 665401 tttatcgctg tcattttaaa caatgcagca aaaggaacgg ccatttacag aacgctcttt 665461 tatctgcctt cgatcatcgg cgggagcgtc gccgtggcga ttatgtggcg caatattttt 665521 ggcaatgacg gggtcatcaa tgcgctgctg ttttttgtcg ggattgatca aaaaattctt 665581 tggtaccaga atccgacaag tgcgctgtgg acattgattc tgctgtccgt ctggcagttc 665641 gggtcgtcaa tgctgatttt tttggccggg ctgaaaaaca ttccgtcttc gtatttggaa 665701 gcggcaagtg tggatggggc aaatcgggtg cagcgtttct tcaagatcac gcttccgatc 665761 cttacaccga ttattttctt taacctagtg atgcagacga tttctgcttt tatgacattt 665821 acacctgcct atatcatttc gaagggcgag ggcgggccgc ttgacgggac acttctctat 665881 tcgctctatt tgttccagcg tgcgtttaac tattttcaaa tgggctacgc atcggcgatg 665941 gcgtgggtca tgcttgtcat tgtcgggctg attacgctca tattgtttaa aacatcgtca 666001 tattgggttc attacgagtc aaaggaggaa tgacggatgg agccggtcaa ccagcctgtc 666061 agagaagccc cggtttttga gagaaaaaaa gccgggcgcg tcagtcccaa acgcatactg 666121 ttccatgttt ttacggcaac gctggcggtg ttgctgctgt acccggttat ttggctgttt 666181 gtcagctcgt ttaaagaaag cgccagtatt tttacaacct cacattctct cattccagac 666241 ccttttattc tcagtaacta tgctgaaggg tggaagggca ttgcgggaca gccgtttctg 666301 acgtttatta aaaactcggc gattattgtc gggctgtcaa caatcggtgc cgtcatgtca 666361 tcggctgtca ttgcgtacgg atttgcgcgt ataccgttta agggaaaaaa attttggttt 666421 gcgtgcatga tggggacgtt aatgctgcct catgaagtgt tgatgattcc gcagtatatt 666481 atgtttgcga aattagactg gctgaattcc tttaaaccaa ttgtcgttcc gcaatttttc 666541 gggcatgcgt tttttatctt tctgatgatc cagtttatcc ggacgattcc cgaggagctg 666601 gatgaagccg cgcgaatcga cggatgcgga cgctttgcct gcttttggcg gatcattctc 666661 ccgctgattg cccccgcgct tgcgacgtct gcgattttct ccttctattg gaagtgggag 666721 gagctgattc agccgctctt gtatttgaat aagccggagc tttaccctgt ttcacttgcg 666781 ctgaagcttt ttctcgatac agagtcggct tcgaactggg gcgcgatgtt tgccatgtca 666841 gccgtctcgt tattgcctgt gattcttgtt ttctttttgt ttcagaaata tatcgttcag 666901 ggcatcagta cgaccggatt aaaataaaaa ggagtgttgc agatggcaca gcttatcttt 666961 gatgaagaaa aggtgacgtc ggttattgac cggatcgtga aacggacatt tcagatggat 667021 tttgcgtggg attggccggg cggcgttgcg ttttacggtg tggcggaggc ctatgaagcg 667081 acggaaaacg aggaatatat caatctgtta aaaacgtggg tggatgaaca gctggaggat 667141 gggctgccgc cgctttcgat caacggagtt tccattgggc atacgctttt gttcctccac 667201 aaggtgacag gtgatgacgt gtatttggaa acagcggccg agatggcgga atatgtgctg 667261 cataaggcgc cgcgctttgg cgagggtatc cttcagcata cggtgaatgc ggcagaatac 667321 gtattccctg aacaggcatg ggcggatacg ctgatgatgg ctgggctgtt tatgctgaga 667381 atcgggcggg tcatggagcg tgaggattat tttgaagacg gcctgcgcca gtttcacgga 667441 catgaggatg tgcttcagga ccctgtcacg aatttgtact accacgcctg ggacaacaaa 667501 gcgcaaaatc atctgtcggg gatttattgg ggcagggcga acggctgggc ggcactcacg 667561 atggcaaagg cgctcccgct tattgaggtg acacatcctt cctttatgat catcgacgga 667621 tcgctcagag accagctgag cgcgcttgtc cggcttcagg atgaatcagg gctgtggcat 667681 acaattttgg atgatccgga ttcttatctg gaggtttcgg catcagcggg tattgcttct 667741 gctctgatgt cgagcggaaa gctgtataca aaatatgtgc agaaatcgct tgccgccatt 667801 ttggatgcag tggaagagga cggacgggtc agcagggtat cggccgggac agccgtcatg 667861 aaaaatgccg aaggatacaa acaggtgcct tacaaacgaa tacaaggatg ggggcaggga 667921 cttgcgctga cgtttcttgc tgatgttttg aaaacgaaaa aacgcttgta tcagtaaaga 667981 tagcggcggg gggagaggga tgaaaaaaca gcctcaacag aaggaacggg tttctcgctg 668041 gaagggaacg tatttcaaaa gaaactttgt cttcattttg ctgattgcct gtattcccgg 668101 attgctgact ggcggcgcaa tctactttct ttcgatcgac aaggtggaga aagagctgca 668161 gagatcgcat gaaacacagg tggcgcgtga ggtcagccga atggatgaga agctgggagt 668221 gcttgaactg gcactcaccc agatggccta cgattcttca ctgatgaacg gattggccga 668281 gagggatttg gagaaagact ttacgttctc ctatcaatta acgaaaaagc tgtttctttt 668341 gcgggatcag cagccgctga tcgagcaggc ttccatcttt ctgaacagcc cccggccact 668401 tgtgctgagc cctgaataca gcgctttgac agaacaggag gcgcttcgca agtatcgctc 668461 gctgcttgcc tcagaccaca gcatttattg gaaacggtcg ggaaaccaag cgatgctgat 668521 ccagctcatt ccgggcgcgg cggagaaacc gttcggcgcg atcatgctgg cggttgatcc 668581 gaaagaaatg gaatcaatcc tgcaaagctt gtccccctat cctgatggca gtgcgttgct 668641 tttagatcaa aatcgagagg tgctgtttca tgagggggaa aaagattttg aaaagacttt 668701 acttcatgag ataaaaaaac agcctgctga gaacggccat tttcagatgg aatggaaagg 668761 caaggtgtat tctgtctcct ttggagaaat gaaccggatg catcagcaat ggacctttgt 668821 gtcagcggcg cctctttcag ctattacagc gccgatggtg tttttatcaa aagtgatcat 668881 cgtgatgctg gtcatttgca tcggtttggc ggtgtgcatg acatggtatg catcaaaaaa 668941 aatctatcgt cccatccagc atttgcttgg cttgtttacc ggaggagaga agaaaacatg 669001 gcaggcgtcc gggcaggatg aattcaaatg gattgaaaag agatggcagg atctatccct 669061 tgaaagccgg aagctccaac agcagctcct gcggcagacg ccccatatga aaaagagttt 669121 tttgcagcat ctcttacaga gcgattttta ctatgacaac gaggaaagcc tcagatttcg 669181 gatggaggag gctggctgga acatcggcgg aaacgtgttt catgtgcttg atctacaggt 669241 gacagggctc cgctgtgaaa aaagcatctt ccgtgaaggt gatgaacagc ttgccgtgtt 669301 tacactgact aatatcgctg aggaattggc ggctaaacgc gtttttcagc tctccatact 669361 tgatatcggc cggctttctg tcaccgttct tgtgatgaaa acaaacagct ctgatctgaa 669421 ggcgtatata acggagctgg cacgccaatt tggagatgta accggactat gcctgacctc 669481 gacattgagc agcaagacgg agcgtgtcac ggaaattcct tctttatttc aggatgtgaa 669541 atgcggcaaa tcccgcagga agtttgctaa ccgggatcag gtcattgatt tgcaggccga 669601 cttccctcgg gatgagcagt tcgctcctta ttaccctttt gagctggaaa aacaaattgt 669661 tcagaccatc cggctggaaa gaaaacagga agccaaggaa ctgatagatg gatgtatgaa 669721 ggaactgtcg gaaaaagcgg ccatagacag gcatgtgcat tccgccctga ttcagctgtt 669781 ttcccgcatt caggaggata ttttgcattc cgggctcaat cccagcgaac tgtttcagca 669841 ccggaatccg tttcttgata tttcagaatt gcgcgaacct aacgaagcgg cggcctggct 669901 gatggatgta gtggtgacgc cttacctttc caagcttgag ggcagaaaaa acagacagca 669961 aaagcagctg gcagaacgtg tgattgcgat gattcacgaa cagtatatgg cggacatttc 670021 attggaaagc tgtgccgatg cgcttggcat gaattcctat acgttaagca aggcatttaa 670081 gcaagtgacc ggcattaatt ttatcgatta tgtgacccag atcagaatcg aaaaggcgaa 670141 agaactgctg gtcaatacga ataaaaaaat tcatgatgtg tctgaagaag tcggctatcg 670201 ccacaattat ttcaatcgga tttttaaaaa acaggtcggc atgccgccgg gtgtcttcag 670261 gcaaatgtat caggaaacgc cgtgaaagga gagaacatgt gatgaagaaa ccgattcaag 670321 tatttttagc gggggattcc actgtgagtg actgcccgcc tcatgaagcg ccgatggcgg 670381 ggtgggggca ggtattcggg caattgtttt ctgaaggtgt gctggtccgc aatcatgcca 670441 aaggaggagc gagcaccaat tcttttgtgg aggaaggaag gcttcaagca attgccgagc 670501 acatcacaca aggcgattat ttgttgattc aattcggcca caatgaccaa aaaccgcggg 670561 ggacgaagcc gtactccaca tttcagcagt ttcttacctt gtttgcagat acggcacgcg 670621 aaaagggcgc gcatcctgtg ttcgtcacat cggtgcagcg ccgccgcttt gatgaaaacg 670681 gacggatcga gcatacgctc ggtgagtatc ccgatgcgat gaaagcactg gcgaaggagc 670741 tcgatgtacc tgtgattgat ctgcttgcga aaacaaaggt gctgtatgaa gcatacgggc 670801 cggaggagtc gaagcgattg ttcgtttggt ttcagccgaa tgaacatccg aattacccgg 670861 acggcattga ggacaatacg catttttcgg aaaaaggtgc aatggaggtt gcgaagcttg 670921 tggcagaagg cattgaagag ctcggacttc cgcttaagga ccaccttgtg agccgggagg 670981 gaaaagaaca tgtataagga aggcgcttgc ttgtaccgca atccgctccg gtctaaaagc 671041 gatgtgaagg attggcggat ggagggaggc ggacagatct catttgacga tcacagcttg 671101 cacctgtcac atgtccagga tgaagcgcac tttgtctttt ggtgtccgga aacctttcca 671161 gacggcatca ttgtgacatg ggacttctct ccgatcgagc agcctggact gtgtatgctg 671221 ttttttgccg ctgcgggtat tcgcggcgag gatttgtttg acccaagtct caggaaaaga 671281 acaggaacat accctgagta tcattcagga gatatcaatg ccctccacct gtcgtatttc 671341 cgcagaaaat acgcggagga aagagcgttc cgcacctgca atttaagaaa aagccgcggt 671401 ttccatctcg ccgcaatggg ggccgatccg ctgccttctc cagacgacgc tgattctccg 671461 tatcgtatga agctgatcaa agacaaaggc tatgtgcact tttcaatcaa tggtctgccc 671521 attcttgagt ggatggacga cggcagcaca tatgggcctg tgttaacaaa aggaaaaatc 671581 gggttccggc agatggcccc catgaaagcc gtttacaggg attttgccgt gcatcaagcg 671641 gtgagaagat gaagacgact gtaacggatg cgctttatgc aggctgcgaa gcggtggtga 671701 aaatagcatg gctcaacggg ctgtggctgt tgtttacact tttgggcggc gttcttttcg 671761 gatgggcgcc gagcacagct gcgatgtgtg ccgttataag gaaatggctg atggggcaaa 671821 aggatgtccc gatattttcg ttatttctcg atacctataa aaaagagttt ctcaaggtta 671881 atgcgatcgg attggcgttt tcggctcttt tgctcatatt gtctgccaac tatcattatt 671941 tttctgccag tacgaattgg ctgtcctttg ccgtaacaag ctgcacgctg cttgcagggc 672001 ttttgtatat catcgcgctg atgtatgtgt ttccccttta tgtgcattac cagctcccgc 672061 ttcgcaaata tattccgcag gcactgctgt ttggcgccat gagaccgctg acaactggct 672121 gtatgctgat cgggtgcgga tttgtccttt atttgctgta tacgcttcct ggcctgatcc 672181 cattttacgg cccgtgttta tttgggcttg tgttgatgtt ttttgctctt aggggatttc 672241 aaaagacgga ggcccagcac catcaagccg ggtaacaaaa aaatgacaaa taagcaaaaa 672301 agtgcagtgt ccgaaatagg cagatgcaaa aaagtgaaat tgaagacagc tcacaaagcg 672361 cataaaatcc aatttaagta agcgcttaca gataaatgag aaggagctgt ctgatgatta 672421 gacgaaggaa acgcatgttt accgctgtta cgttgctggt cttgttggtg atgggaacct 672481 ctgtatgtcc tgtgaaagct gaaggggcag cgcggcagat ggaagcgctg aaccgggggc 672541 ttgtagcggt caagacggac gggggcattt ttgtcagctg gcggtttctt ggaaccgaaa 672601 acgcatctgt tttgttcaat gtgtacagag acgggcaaaa actgaatgct gcgcctgtca 672661 aaacaacgaa ctatgtggat aaaaacggtt cggcgggctc aacgtatacg gttcgggctg 672721 ttgtaaacgg taccgaacag ccggcttctg aaaaagcctc cgtatgggcg cagccgtatc 672781 attccgtccc gctggataaa ccggctggcg gcacgacgcc aaagggtgaa tcttacacgt 672841 acagcgctaa tgacgcaagt gttggcgatg tggatggtga cgggcaatac gagctgatcc 672901 tgaaatggga cccgtccaac tcaaaagaca attcacagga tggctatacg ggtgacgtgc 672961 tgattgacgc gtataaactg gacggcacaa agttatggcg gatcaatctc ggcaaaaaca 673021 tcagagcggg cgcgcactac acccagttta tggtgtatga ccttgatggt gacggaaaag 673081 cagaagtggc aatgaaaacg gcagacggga caaaagacgg cacgggcaaa gtaattggaa 673141 atgccaatgc agattacaga aatgaacagg ggcgtgtgct ttcaggccct gaatatctca 673201 ctgtgtttca aggttcaacc gggaaagagc ttgtcaccgc aaattttgaa ccggcgcgcg 673261 gcaatgtgtc ggattgggga gacagctacg gcaaccgtgt tgaccgtttt ctcgccggca 673321 ttgcctacct tgatggacag cggccgagcc tgatcatgac cagagggtat tacgctaaaa 673381 ccatgctagt tgcctataac ttcagggacg gaaagctgtc aaagctttgg acgctggact 673441 cctcaaagtc aggaaatgaa gcgtttgccg gacaggggaa tcacaacctg agcatcgcgg 673501 acgttgacgg ggatggaaaa gatgagatta ttttcggctc aatggctgtt gatcatgacg 673561 ggaaaggcat gtactcgacc ggcttaggcc atggggatgc cctccataca ggagatcttg 673621 atccgggccg gccggggctt gaggtgtttc aagttcatga ggacaaaaat gcaaaatacg 673681 gcttatcttt ccgggatgct gcaactggaa aaatcctttg gggcgtttat gccggcaagg 673741 atgtaggccg gggaatggct gctgatattg acccgcgtta tccgggacag gaggtgtggg 673801 caaacggttc tctctactca gcgaaagggg tcaaaatcgg aagcggggtt ccgtcctcga 673861 ccaacttcgg catctggtgg gacggcgatc tgctccggga acagctggac agcaaccgaa 673921 ttgataagtg ggattatcaa aacggcgtat cgaaaaatat gctgactgca tcaggcgcag 673981 cggctaacaa cggcacaaaa gcaacaccaa cgcttcaggc tgatctgctc ggtgactggc 674041 gcgaggaagt ggtgtggaga acggaggaca gcagtgctct gcgcatttac acgacgacca 674101 ttccgactga gcacaggctg tatacgctga tgcacgatcc ggtgtaccgg cttggcatcg 674161 cctggcaaaa tatcgcctat aaccagccgc cgcacacaag cttcttttta ggagacggca 674221 tggcggaaca gccaaaacca aatatgtata cgccttaact gaaaggggga aggaacgggc 674281 tgcgcgcagc ccgttcccat caaatgaaac caaaaaagag gcaaatggaa tacctgacca 674341 gaggtttgat tgcggtacag acagaacagg gcgtgtttgt cagctggcgt tttctcggca 674401 cggatcatga gacgacggct tttcaccttt atcgggatgg aaagcggatc acccgcgatc 674461 caatcgctga aagcactaat tttctcgatc aaaacggaac ggctgactct gtttatcaag 674521 tggcggctgt caataaagga cgggaagaaa agctttccaa gaaagctcgt gtttggcagg 674581 aaaatgtcct ggaggttcct cttgccaaac cggaaggcgg tgtgacgccg gacggaaagc 674641 cgtacactta cagcgccaat gatgccagtg tcggggatat agacggggat ggagaatatg 674701 aaatgatcct gaagtgggac ccgtccaatt caaaagacaa cgctcatgac ggttataccg 674761 gggaggtgct catagatgcc tataaactgg acggcacctt tttgtggcgc atcaacctcg 674821 gcagaaacat cagagcgggt gctcattaca cgcaatttat ggtgtatgac cttgacggtg 674881 acggaaaagc agaaatcgcc atgaaaacag ctgacggcac aacagacggg aaaggacata 674941 tcatcggtga tgagcaggcc gattttagaa acgaacaggg cagaattttg tccggtccgg 675001 aatatttgac cgtgtttaaa ggagaaaccg gtgaggcgct cacgaccgtg gaatatgaac 675061 cgccccgcgg caagctggag gattggggag acggctatgg aaaccggatg gaccgttttc 675121 tcgccgggac cgcttatttg gatggggagc ggccgagcct tgttatggcg cgcggctact 675181 atacgagaac cgtgctcgtg gcatacgatt tcagaaacgg aaggctcaaa aaacgatggg 675241 tatttgactc caaccagccg ggacatgaag catacgcagg acaggggaac cacagcttga 675301 gcgtggcgga cgtcgacgga gacggaaagg atgaaatcat atacggcgca atggctgtcg 675361 atcatgacgg aaccggcctg tactcaacgg gcctcgggca cggagacgcg atgcatgtag 675421 gggatctgga cccgtcacga aaagggcttg aagtgttcca ggtgcatgag gacgccacga 675481 agccgtacgg actgtcgctg cgagatgccg gaaccggtga gatattatgg ggcgtccatg 675541 ctggaactga cgttggccgg ggcatggcgg ctcatattga tccaagctac aaaggatcgc 675601 tcgtctgggg aattgatccg ccgggcaatg atggcatgtc gtacgggctt ttcacgagca 675661 aaggcgaaaa aatcagcgac aaagcgccct cttcagccaa tttcgccatc tggtgggacg 675721 gtgatttggt cagagaactg cttgatcatg actgggacgg aacgatcggc aggccaaaga 675781 ttgaaaaatg ggatgctgaa aacggctgtc tgaagacgat atttcagccg gccggcgtgt 675841 tgtccaacaa cggcacgaaa ggaaacccgg ttcttcaggc caacctgttc ggagactggc 675901 gggaagaagt gatatggaga acggaagaca gcagcgcgct ccgtatctat acaacaacac 675961 atctcacccg ccactgcttt tacacgctga tgcatgatcc ggtttacagg ctcggcatcg 676021 cctggcagaa taccgcctac aaccagccgc cgcacacgag cttttacctc ggaacgggaa 676081 tgaaaaaacc gccgaagccc gccctgtaca tagcgggaag caaagcggag gcgccgctgt 676141 aggaggacta agggataaga cgcaaaggct gaacgctacg ccaagatgat tagagaactg 676201 gcaggacgaa ccaatgctca agcgctgtac gcaccggttt tttcaaggga agagctatcc 676261 gtgatggaag ctgtataaaa aacgaggagg aatgaaaaaa tggcaaatca tatttatctt 676321 gccggcgatt cgactgttca aacgtatgga gacagcacaa atcaaggggg ctgggggcag 676381 tttctcggct cgcatctgcc ggagcatatt caagtgatca acagagcgat cgggggaaga 676441 agctcgaaaa catttgtgga agagggcagg cttcaggcaa tcctcgatgt gattgagccg 676501 gatgattggc tgttcgtgca gatgggccat aatgacgcgt caaaaaataa gccggagcgc 676561 tacaccgagc cctatactac ttataaacaa tatttaaagc agtatatcgc aggcgcgcgg 676621 gaaaaaggcg cccatccgct tctcattacc cccgtagccc gctttcatta cgaaaacggc 676681 gtgtttttga acgattttcc tgattactgc attgccatga agcagacggc cgctgaggag 676741 aatgtccagc tcattgatct gatggagaaa agtctcgctt tctttactga gaagggcgag 676801 gaaaaagtgt acacctattt tatgatttca gaagggatta acgattacac gcattttaca 676861 aaaaaaggcg caaatgaaat ggcgaaactt gtggcaaaag gcataaagga gctcggcctg 676921 ccattgacag aatcgatcat caaagaaagg tgaaaatgtg atgagaaaac tgtatcatgg 676981 cgcttgctat tatccggaat tatgggatga agagacgatt cagcaggaca ttgacatcat 677041 gcgtgaagtt ggcgtaaatg ttgtgcggat cggcgaattt gcctggtcag tcatggaacc 677101 tgaagaagga aaaattgacg tcggtttttt caaagaaatc atcgcccggc tgtatgatag 677161 cgggatcgaa acgattatgt gcacgccgac gcctaccccg ccgatttggt tctcacatgg 677221 ccggcccgaa cgcatgcatg ccaatgaaaa aagagagatc atggggcatg gctcccgtca 677281 gcatgcctgt acgaacaacc cgtatttccg aaaaaaagcc gccatcatca ccacagccat 677341 cgccaaggag cttggccggc tcccggggct gatcggatgg cagctagaca atgagtttaa 677401 atgccatgtt gcagaatgca tgtgtgagac atgcttgcgc ctatggcatg actggctcaa 677461 aaatcgctac ggggtaattg agcgcttgaa tgaagcttgg ggaaccgatg tgtggagcga 677521 gacctatcag acgtttgagc aagtcccgca gccgggaccg gccccgtttc tgcatcatgc 677581 ctctctacgc actatgtatc agctgttttc gatggagatg atcgcttcgt ttgcggatga 677641 acaggccaaa atcatccgct gctattcaga tgcgccgatc acgcataacg gatcagtcat 677701 gttcagcgtg gacaatgagc gaatgtttca gaatctcgat tttgcctcct atgacacgta 677761 cgcttcgcag gaaaacgcct ctgccttttt attgaactgt gatttatgga gaaatctgaa 677821 acaagggcgc ccgttttgga ttttggaaac gagtccgtcg tatgccgcct cgcttgaaag 677881 ctccgcttac ccgcacgcag acgggtattt gcaggccgaa gccgtatcgt cctacgcctt 677941 agggagccag gggttttgct actggctatg gcgacagcag cgttcaggca gcgagatttc 678001 ccacggttcg gttctcagtg cctggggcga acccaccatc ggctatcaaa atgtgctggc 678061 ggttgagcgg gcaagaaagg aaatcgagcc tattattcta tcgactgaac ccgttcaagc 678121 cgaggcggcg atgacttact ctgacagagc aaaagcattt attaaaactg agcctcaccg 678181 gggactccgg catcgttcgc ttgtgacgca tttttatgaa cgtattctca acacggggat 678241 tcaccgtgac cttattccgg aaggcgctcc actggacggc tatcgcttgc tgtttacgcc 678301 atttgtgccg tatttgtctt ctgaatttat caaaaaagct tcggcattcg ctgaagcggg 678361 cggcatctgg atcaccgggc cgctgacagg aggacgcaca tgcgagcata ccattcatac 678421 cgattgcgga cttggcgaac ttgagaaaac gtcagggatc aaaacacttt ttacctttcc 678481 gatgaatgag aacgtgaata caggaaaagc gtttggcatc acggcgccgc tcggactgtg 678541 gagcgcggtg tttgacacag agagcggaaa cacccttggc acggttgaag caggaccggg 678601 ggcgggccat gcttttctga cggaacggaa ttacggcgag gggaaaattg tcatgctggg 678661 ctcgcttcca tccgggaaag aaggggatgc gatgctggaa gcgctcgtca ggcattatgc 678721 ggaggaagct gttatttcca gccggtcgga tgtgacaccc ggcacgatcg ttgccccgcg 678781 tataggcgaa aacggccttg tgtggatcgt tgtgaatatg gatggaaaag gcgggagcgt 678841 gacattgccg gaatcgggaa cggatttgtt gacgcaccgc ttggaaaagg cggggagact 678901 ggcggtcgga ccgcatgaat accgtgtgat tcaatttgac aatcacagct gattctttgt 678961 atcgaatcag cttttttcta tggagggaga gacagatgaa aaagatcaaa tggttatcag 679021 gacagccaaa ggtgacaagc ggcgtgacgt ggggcatgcc atggaaaaaa ggagaattaa 679081 aaaaaggaga ccgtctggcg cttatgaatg aaaacgcgga aacgcgatat gtgcaaagcg 679141 aaccgtcggc ctattggccg gacgggagca tcaagtggac gaagcacgcg gcggtgtttg 679201 gcggtcagga aaaccaaagc tttacagtgc acaaaagaga agtgccgcag ccaactgaat 679261 cgctcagcat tcttgagaca gagcatgata tccaagtgga tacaggagca ctcgtttgta 679321 ccattcataa aacaggatct gatttcattc aatcattgca gatcaatgga aagccgatcg 679381 ccgcaggcgg gaggctcgtt gcgataagag aaacgagaaa agagtcagcg gcgaaaatgg 679441 ttcttttgca tgaaaggtct gtcagcttta tcaaacgggc ggcgattgag cagagtggtc 679501 ctgtcaaagc agtagtcaaa atcgagggag tgcatgtgct tcataaaacg tatgaggaat 679561 ggctgccgtt tgtcatccga ttaacgtttt atgccgggct gtctgagatc ggccttgtgc 679621 acacgcagct gattgacagg agcggtaaac tagaattcgt taaggggctc ggcatcgaat 679681 tcgacctttt tttggaggga gagccgtaca accgccattt ccgctttgcg ggagagaaag 679741 ggatgtataa agaacccgcc cagctgtttg gcacacgtaa attcaatgaa cgatatccgc 679801 tttatgaaaa acaaatcaat ggcgaaatgc tgtctccaga tgaagagcat aaggaatggt 679861 ttgcacatgg cacacagaat gcggtttggg acgatgtcaa gatcgtgcaa gattccagcg 679921 atcattacag cctgtcaaaa cggaccggaa aagattatgc gtgggttgga atgctgcatg 679981 gcagccgggc gaaggggctc tgctatgcgg gcggaaaaaa tggcggtgtg gctctcggcc 680041 tgcggtattt ctttgagaaa tatccttcag cactggaaat cacaggtctt gccggcagcc 680101 gccccaaaat gactatctgg ctttggcctc cggacggcga agcgatggat ttgcggcatt 680161 atacaggaaa cactcacgtg gccagcgcgt atgaaggctt tgatgaaatg cgctctgatc 680221 cgacaggcat tgcgaacaca aatgaaataa gcctggcgtg cttttcgcac atgccgtctg 680281 acgaagtcct caatgcgctg gctgacaaat ggcaggcgcc cccgctcatt gtatgcgagc 680341 cggacgtcta ttacgaatca aaagcactcg gggtatggag catcattgac acatcccatc 680401 cgctcaaaaa agagctggaa gaacagcttg atgcggcctt tctgttttat aaaaaggaag 680461 tagagcaacg cagatggtac ggtttttggc attatggcga tgtcatgcat acgtatgacc 680521 cgatccggca tatgtggcgg tacgatctcg gcggatacgc atggcaaaac aatgagctcg 680581 ttccgaccct atggctgtgg caggcgtttt tccgctcagg cagagaggat atcttccgaa 680641 tggcagaagc catgacccgc catacgagtg aaacggacag ctttcacctc ggtgaatatg 680701 ccgggcttgg ctcacggcat aatgttgtgc actggggatg cggctgcaag gaagcgagaa 680761 tcagcatggc cgggcttcat aaattctatt attatctgac gggtgatgac cggacgggag 680821 atcttttgac agaagtgaag gatgccgatt atgcccttgt caaaaccgat ccgatgcgcg 680881 ctttttacga gaaaggcaag cacccgactc acgccagaac gggaccggac tgggcggcgt 680941 tttgctcgaa ctggctggcg gaatgggagc ggaccgaaaa ttcggaatat ctcaaaaaaa 681001 tcgaaacggg aatcaactgt ctgaagcggc tgccgctccg cttattatct ggcccgacat 681061 ttgaatatga tccggcgacc tcgatgcttc atcatatggg agacggcatt gcgggcggat 681121 atcatatgat cattgccttc ggcgcgccgc aagtgtggat ggagctggct gagcttcttg 681181 atgactggga atgggaggat atgctgagtg aattcggcga attttacaca ctcagtgatg 681241 aggaaaaacg aaaaaaaagc ggaggcgctc ttcatgacgg gcattttcac tggccgatgt 681301 tcgccgccgg tatgacagcc tacgccgcaa gaaaaaagca agatcctcat ctcgccgcca 681361 aagcgtggaa tcttttgcta gaagataagc tcagccatac gccgcttccg atcaaaccgg 681421 agcgcatcga gacatggacg cagctagagg agcttccatg ggtgacaacg aacactgtct 681481 ctcaatggtg tttaaatgtc atagcggcgc tggaactgat cggagattcc cttccggcaa 681541 aaaaagaaac atcgggcaaa aaaggataac agccggaatt tcataggaga aatggtgcaa 681601 aaaatgaaga ttgcaagaat ttatgtaagc gctttatatt gagaggggca aaggggaaat 681661 gcaaattgaa aaaaggggga cttacgcaac atgaaaataa gaatgcgaaa aaaatggatg 681721 gccttgccgc ttgctgccat gatgatcgcc ggatgcagcc attcggaaac atccaattca 681781 gcaagcggtt cgaaagatac gatcaaaatt atggcgccgc tcttatcgcc ggaaagccca 681841 agtgataaga gcccttcatt aaaagcgctc gaaaaataca caggcaaaga gattaaggtc 681901 acatgggtgc ctgattcatc ctacaacgac aaattcaaca tcgtcatggc ttcaggagag 681961 atgcctcacg cgattgtcat taaagataag tcagccggct ttatcaaatc tgtcaaagca 682021 ggggcgtttt gggagctgtc tccttattta aaagactaca agaatttaag ccaggcagat 682081 gaaaagattt tgaagaacag ctcggtgaac ggcgaggtgt acggaatcta cagaacgagg 682141 gatctgatca gggcgtgtat gatcatcaga accgactggc tgaaaaatgt cggtctggat 682201 atgccggaaa cgcttgatga tttctatgaa gtgctgaaag cctttaagga aaaagatcct 682261 gacggaaacg gcaaggatga tacgtacggc atggtcgtgc cgaaatggat gggactcggc 682321 aacggaagcc catgggatgt tctgcaaatc tggttcggcg ctccgaaccg ctacggtgtt 682381 gaaaacggaa agctgattcc agattttaca acgaaggaat acatggatgc gctcacgttt 682441 tttaaaaagc tctatgatga gggcttgatc aataaggact ttgctgtcat ggattctgcg 682501 aagtggaatg atccggttgt aaaaggaaaa gcgggtgtca tcgttgatac aggctcaaga 682561 gcgtctcaaa tccaaagcgc gatggaggag gcggatgagt cgaacaagga tatcattgat 682621 atcgtcggct cgcttgaggg accgaatggc aagcgcacct tcccgacatc tggttattca 682681 ggcatgatca cgataccaaa atcaagcgtc aaaaccgaaa aagagctgaa agaggtgctg 682741 tccttcctcg ataagatgaa tgataaggaa gcgcagattc tcacgaacaa cggagtgaag 682801 ggccgcaatt acgagctcaa ggacggcgta ttcacctcac ttgaaaaaaa caataaatct 682861 ctcctgtatg agcatgaagg cttggcacag ttcagcatgt cgattccgaa aagcgagtat 682921 tacatcgaag accagaaaac caagctcttc cagcatcgca aggacatcat aaccgaagga 682981 gaaaaaatag ccgtctttaa ccctgctgag tcgcttgtat ctgatgtcta tacccaaaaa 683041 ggagcccagc ttgacaacat catcctcgac gcgagaacac aatttatcat tggagaaatt 683101 gatgaaaaag ggttcgatga tgcggtggag ctttggaaaa aaagcggcgg caatgaactg 683161 atgaaggact tgaacaaatt gtaccaatcg tcaaaataaa ccgatgcgcc tgcctttcgg 683221 cgggcgcccc ggtatcacga aaggagaaca gatatggaaa cagtgccgaa gaagagagat 683281 gcacctgttc tcaccgctgg aaaaggcatc agctggatgg ctgcgctcaa acgggacaaa 683341 tggctttatc ttcttcttat tcccggtctg ctttatttct tgattttcaa atacttgccg 683401 atgtggggtg tgctgatcgc ttttaaagac tattcgccat atctcggctt ctggaaaagc 683461 gaatgggtcg gctttgatta tttcaaagac ttttttatga atccggattt tttccggctg 683521 ctgcgcaaca ccctcatgct ggcgagtctg gatcttttgt ttgcctttcc cgcgcctctc 683581 attttggctc tgcttttgaa tgaggtaaga aaggccgtgt ataaaagatg tatccaaacc 683641 tttatttacg taccccattt tgtatcatgg acaattgtgg tcagcatcac cttcgttttc 683701 tttactgtcg atacaggtgt gatcaacaaa ttgattatga gcctgacagg tgagcagatt 683761 tctttcttgt cggatgcaga ctggttccgg ccaatgattg tgatgcaaag catttggaag 683821 gagacaggct ggggaacgat tctatttttg gcagcgcttg ctacggttga tcaagagcag 683881 tatgaagcgg ccatcatgga cggagcgggg cggttcagga gaatgtggca tattacgctg 683941 ccggcgatta gaagcaccat tatcgttttg ttgattttaa gaatcggcag ctttttgaat 684001 cttggctttg aacaggtgta tttgatgacg aactcactca accgcagtgt ggctgacatc 684061 ttcgacacgt atgtgtacat gatggggatt acccaagggg cgtatagcta cagcacggcg 684121 gtcggtttgt ttaaatcagt tgtcgggatt atcttgattt ttggcgccaa ttacattgcg 684181 aaaaagtttg atcaggaagg attgttttag aggagggaga ggtatggctg aaattcacac 684241 gatgcacaac accaaagccg gacgggtgtt tgacgtctgc aacattctgt ttctcggcgg 684301 tgtcggcgcg attaccattt tgccgttttt atatattatc gccggttcct ttgcgacaga 684361 agcggaactc gcccagcgga gcttctttat tttcccgaaa acctttacac ttgatgctta 684421 caagtatgtg ttttcgacac cgacgttcct tcgaagcatg ggcgtgtcca tcttcatcac 684481 ggtggttggg acggctgtac agctgttttt taccttcacg atggcgtatc cgctggcgaa 684541 acggcatgtg aagggacgga atctgctgtt gaatctggtg attttctcca tgctgttttc 684601 aggcggcatg attccgacgt accttgtcgt aaaatcactt ggccttttgg atacgtattg 684661 ggcattgatt ctgccgatgg cgattaatcc gttcaacctt attattatca aaaacttctt 684721 tcagcagctg ccgcgcgagc tggaggaatc agcaaaaatt gacggctgtt ccgaaatcgg 684781 cgtcttctgg cggatcgccc tgcctctgtc aaagccagtt attgcgacct ttgcgctgtt 684841 ttatgcggtc gggatttgga atgatttctt ccacgctctc ttatatatca atgacagtgc 684901 aaaatggccg ctgcaaatgg tgcttcgcca agtcacaatt ttatcggatt taacggcgac 684961 caatggtgat acgatgcaaa atgcagttcc gccggagcag ggaattaaac tcgctgtcat 685021 tgtcattgcg acgctgccga ttttggcggt ctatccattt ttacaaaaac actttgcaaa 685081 aggaatgctg atcggttcgg tgaaaggctg agaaagggag tgtttcatat cagtacatta 685141 gatcagatta agattgccta tatcggcggg gggtcccaag gctgggccag aagcctgatg 685201 agtgatttgt cgattgatga acggatgtca ggcacggtgg cgctctatga tcttgatttt 685261 gaagccgctc agaaaaatga agtgatcggc aatcacagcg ggaacggcag atggagatat 685321 gaggctgttt ctactttgaa aaaggcgtta tcagccgcgg atatcgtcat tatttccatt 685381 ttgccgggat cactggatga tatggaagtc gatgtgcact tgcctgagcg ctgcggtatt 685441 tatcagtctg taggtgatac tgtcgggcct ggagggatca tcaggggctt gcgtgctgtg 685501 ccgatatttg cggaaattgc ccgggcaata agagactacg cacctgaatc atgggtcatt 685561 aattatacaa acccgatgtc tgtctgtaca agagtgctgt ataaagtgtt tcccggcatc 685621 aaagcgattg gctgctgcca cgaggtattc gggacgcaaa agctattggc ggaaatggtc 685681 acggaaaggc tggggattga ggtgccgcgg cgtgaggata tccgcgttaa tgtgctcggc 685741 attaaccatt ttacatggat cacaaaagcc tcttaccgcc atattgacct gttgcctata 685801 ttccgtgaat tcagcgcgca ctatggggaa tcaggatatg agctggaggg ggaatgctgg 685861 agggacagcg tcttttgttc ggcacaccgt gttgcgtttg atttatttga aacgtatggc 685921 gccatccctg ctgcgggtga caggcatctg gcagagtttc ttcccggccc atacctcaaa 685981 cagcctgaag tatggaaatt tcatctcaca cctatatcat tcagaaaaca agacagagct 686041 gagaaacgac aagaaacaga acggttgatc gtgcaacaac ggggcgttgc tgagaaagct 686101 tcgggagaag aaggcgtgaa catcatagcg gctcttctcg gattgggtga actcgtcaca 686161 aatgtaaata tgccgaatca aggccaggtc ttaaaccttc ctatacaagc cattgtcgaa 686221 acaaacgcat tcatcacaag gaaccgtgtc cagccgattt tgtccggagc gcttccgaaa 686281 ggtgtggaaa tgctggcggc taggcatata tccaatcagg aggcagtggc ggacgcaggt 686341 ttaacaaagg atactggcct cgcgtttcaa gccttcctca atgacccgct tgtccagatt 686401 gaccgcagtg atgcagagca gcttttcaat gacatgctcc aatgcatcat gcaaagctga 686461 gcttgccgat tagctctttc cggtttagaa aggaaagcat tgaccatact gatagtataa 686521 tcaagaagta ggtgctatca atatgggaaa ttatttaagt gttgcggtag aactggtctg 686581 cggtttaggc attttattta tcatcttaaa gcttctcggg aaaacccaat tttctcaaat 686641 tacgccgttt gactttattt ctgctttaat tttaggtgaa ttggtcggaa atgccgtcta 686701 cgatcatgaa atcaaaatca aagaaattat ttttgcttcg ctattgtggg gcgtgctgat 686761 ttatattatt gaatttatca cgcaaaaaat gaaatcatcg cgaaagttct tggagggcga 686821 gccgaatatc gtcatccgca aaggggagct tcaatataaa gtaatgaaga aaaataagat 686881 agacattaac cagctgcaaa gcctattgag gcaagctggg agcttttcga tccaagaagt 686941 agaatatgcg attcttgaaa caaacgggat ggtcagcgtg cttccaaaat cagactttga 687001 caaaccgaca aataaggatt tgcagattcc ttcgaagtcc gtttctctgc cgatcacgtt 687061 aatcatagat ggagagattg tgcgggataa tttgaaggaa gcaggtgtgg atgaacagtg 687121 gctgaaacaa gaattgaaaa agaagaacat tgataagaca gaggacgtgt tatttgcaga 687181 atggcataaa aataagccgc tgtatactgt aacgtacgaa caaagcagat caacatgact 687241 cttagaaaaa agcttgcagc aaggcgcaag ctttttattg attgtatgtc ccttgtttga 687301 cagcacgtac atggtacatg ctcacttcag tgctgatcag atagtcaggc tttggtttgc 687361 ctttgtttgc tttatggccg gcgatatgcg catcgctttt ttcccattgc ttccagtgat 687421 cctctgattc ccagcgaatc atgacaacaa cttcttcatc accgcggcgc acatttttct 687481 caagcactgt cacatcaatt aaaccttctt gtttttcaat gattccttca gcgctgaaac 687541 gttctatgac tttatctgca aagccttctt taaccgtcat ttttctcaac tgtacaaaca 687601 tttgtctcac tccaatcatt ctcacatatg aataattgta aatgaaattc attctcaatg 687661 tcaaagaaag cgcagggcgg aatcgaaccg ccgtgcgcaa cagtttattc ttttaataaa 687721 aacacatttc cgtcttcgtc cttaaattga acgaaggtgc cccactccat ttgattgggc 687781 tcaccgagaa attctacacc gtttgtcttc attttctcgt atgtaccaaa gatgtcttcg 687841 cattcaaaca caatagaagc cttcatttgc tctgagcctt tcatcatggc tttcgggtaa 687901 atgactaaac gagtctcggc tccttttggc gcaacctcca gccagcttgc ttcaggtccc 687961 attgggtgat ccgctgcaat atcaaagcct accttctctg tccaaaattg cttcgctttc 688021 tgctggtcct cgacatatac agcaacagtg ccaatttgtt tgatcatagg gaaacctcca 688081 agttgaaaag ataataatac tataacctgt ttacggccga agtaacataa aaaaatcagc 688141 cgggaaaccg gctgattatt aaaatgagca gcttacaaca tcgatgtgat ttgtgtctaa 688201 ggcgaaataa acccagcggc gccgtgagga atcccaataa aagccgccga cggatcttct 688261 gccaaggatg atcgggtaaa accaaaatga gcggccattg gttaaccaga cataggtaaa 688321 tcggaaaagg caaggacgaa tggtgattgg ttcaactaac aaaacggctc cttgagaacc 688381 ctgcggtttt gggggtttcg ctggtatttg ggaaggagga ggtccctgcg gcgcaccgcc 688441 gaagcctggg ctggcaccgc tgccaatacc agggccggag ccgccgccaa agcctggaac 688501 agcaccaccg ccaatgccag gaccggagcc gccgccagag cccggaacag cgccgctgcc 688561 aatgccaggc catggatatc ggtattcata ttcaaaagca ggccaaggct cataaaaatg 688621 ccccgcaaac atataaggat caacataata catgtgataa cgtcctttct cattgtaaac 688681 tgtacattgc agtttatgcg ggcggactct tattggtgca ttcgcctaag gatatgaagc 688741 tggaatgctc tcagagagca gaatcatttg atttttctct agtcttattc acaattccga 688801 tttatcattt tataatgaaa gtgcttctat tacgaaaaag gagacagacc gtgaatatcg 688861 atcaattatt atatcaatat atcatagaca acactgcgga tattactgag aaatggttca 688921 gtttgcgttg ccagctaaaa ggcgagctat attccgccag ccatttaagt gaagaaacga 688981 aaacactttt aaccgagcag catacattta ccaatataac aatcgcaagc gcatttctgg 689041 aggatcaaac cgattttcaa gaaaacatga caaaatgggc gcaaaacgtt gcgaaaaaca 689101 gggtagagca ggatgttcaa gtgcatgagg tcgtagaagc catatccaat tcaagaatct 689161 cattctggga cgcagtcgcc acatttataa aagagaatca ggagattgtg acaaatgagg 689221 atgcagaccg atggaaccgc attgtgaatc agtcgttcga taagctgatt attgaattct 689281 ccgagcagta ccaaaaattc atgctgatga ggcttacatc tcagcaggaa ctgatctcag 689341 agcttggctg cccggtcatt tccattgccg atggaatcgg gatattgccg cttatcggct 689401 ccattgatac aaaacggcac aggtcatttt agaaacagtg ccggtccgct gtgtcgagag 689461 aaaaatcaca agcctcgtcg ttgatctttc gggtgttccg attgtggata ccatggtggc 689521 tcagcaattg tacaacctgt ctaaaacact tttcttatta ggcgtcaaag ccgtattttc 689581 aggaattcgc ccggatgtgg cccaaacatc gattcaattg gggcttgatt ttagtgaata 689641 tgaaacgtac ggcacgctga agcaggcatt agaaaacatg ggtgtccgct gtattgttga 689701 ggaattggaa gaaaacaaat aggaagtttc caggcatatg attgtccgtc accgggtgat 689761 catatgcctt tttgatttga acagaaatca ccattgattt atcgaaaaaa acataatatt 689821 ataattctta taagaatact gtgaattaaa acctattcaa caggggggaa ggtcttttgg 689881 tttctaaatc aacgattgat ccggaagtga ttgaaaaaat catcagctcg ctggaaacac 689941 tcgatttcgg cacggttcag attacggttc atgattctca gattacccaa attgagaaaa 690001 tagaaaagca ccgtttttcg ctgaaaagga aagaatcaaa atgataatgt aaagggcgtt 690061 tgttttcatt aaattctcct taaaacatat acatatttca tccaattttt atataataga 690121 cctttaagat cattttttag gaggattttt gacatgcaag ctacggttca cgagagtaag 690181 caatcgatca tgcaacgcat tttgacagtc tttgtcttca cattgctgat cgcgactgtc 690241 ggccttttta tcggccaatt tgttcctgtc gctttgatgc tgccgctttc tattcttgaa 690301 gtggcgatga ttattctggc cttctggatg cgcagaagaa aagcggtcgg gtatgcgttt 690361 gtatatacat tcgcgttcgt ttccggcatt accttatttc cgatcgtcag ccattacgct 690421 tccatcgccg gcgcctatgt cgtgctcgaa gcctttggct ctacatttgt catttttgcc 690481 gtcttgggca caatcggcgc aaaaatgaag aaggatttat ccttcctgtg gtcgtttctg 690541 ctggttgcgg tgctcgcact cgcagtggta gggattttca acattttcag cccgttaaac 690601 tcagcggcga tgatggcgta ttccgtgatc ggaaccatcg tcttttccct ttacattttg 690661 tatgatttga accaaatcaa gcaccgccac attacggaag acttgattcc ggttatggcg 690721 ttatcgctgt acctagactt tatcaacttg ttcatcaacc tgctccgctt cttcggcatt 690781 ttgagcagtg atgattaatg aaaaagcgtc tgtcattgga taggcgcttt ttgccataca 690841 tcaaaaaggc aggtggagta ttggtgaaaa aacaaatggg cgcatatgta tctctggcag 690901 cagctatggc gatcgtcggc agttctgtcg ttgtcggcaa gctgatggtc gaacggattc 690961 cggtctttct ttcctcagga ttgcgttttt tgatcgcttc tgtcgtattg ctcatgctgc 691021 tgttttgcat tgaaaaaggg tttccggctt tgacgaaaaa agatgtgttc gtattactgg 691081 tgcaatcatt cacaggcgtg tttttgttca gtatttgcct gctgtatggg gttcaatata 691141 cgacgggaac ggaaagcggc attttgacaa gcacaacccc catgttgatc ggtattttat 691201 cctttttcct gctgagagaa aaaattgaga aaaagacgct gatcggcatt ttgctggcgg 691261 tttgcggcgt aatggcgatt aatttgtttg gagccgggag ccaagacggg acgccgcacg 691321 ccttattcgg gaacatgctg atcattgctg cagtcattgg cgaagcgttg tttacattga 691381 tggccaagct gctatccccg catatttcgg cactggcgat ttcgaccttc gtatcgctct 691441 tcggcttcct gttttttctc ccgtttgctt tgtttgaggc ctcttcattt gattacagcg 691501 tgccgactgt tttggattgg tcgtatgtgc tgtattacgc gctttttgtc actgttttgg 691561 cgttttactt atggtatagc ggggtgacga aggtgccggc gggtgtatcg ggcattttca 691621 catccgttct tccggtctca gctgtcattt tgtcaggcgt gatattgaag gagccatttg 691681 agtttgtgca tttcatcggc attgcatgtg tcatcggcgg catatttgtt acggtcataa 691741 agaaaaaaca gccggatgcg tatccggctg cagaagaaaa gacgctatag cctgtccgga 691801 tcggacgggt tttttagtct ttaaacacgc tcagcctttc aaaaagatca ccaagcatct 691861 tcacgaacat gtctttttcc tcgtcgctgt agttttccat gacagcggat attttgctga 691921 aatggccggg cagaaattgc tccaggcgtg ctttgccttc tgttgtcagt tcaatgctga 691981 tttttcgttt atcctctgtg tgatgcctgc ggctgacaaa accgtctctc gccagcccgt 692041 ctagcaggcc tgtaattgtt gctttcgtga catttgaccg cttggcaagc tctgtcggac 692101 ttaacctatg atccttggca tcaaagagca gcatcaggat tttgaatttt ccttctgaaa 692161 gccctcggcc agcaaagtaa tgctccatca catgattcat tttttttgaa atatcaaaaa 692221 gagataaaaa caattcaaga gagccggcgt caatattggc atacgtttcg gcgtgctctg 692281 ttatatgctt atatttcggt aaatgtttta attccatcgc aattagctcc cgtacattcg 692341 ttgtgacacg attataaagg agggaaaacc ataacgcaac ttggcttgga gatgattgac 692401 agcttttctt gggacatagt aaggtaatat agttaggcgc ctaactaata catatagagc 692461 tgaaaaggtg gttattgata tgaaacatat gttaatagca ggaggcggaa tcggcggctt 692521 gtcagcggcc atttctctcc gtaaggcagg gttttccgtc accttatgtg aagcggcttc 692581 agaaaatcga aaaacaggtg cggggattct tcagccgcaa aacgcactgg cggtgttgaa 692641 agaactgggc gtattcgaag attgctgtaa gcacggcttt caaacagaat ggtttaaaac 692701 gtttgatgaa caggggaatt tgctgtttca agtcagtgaa tcctttttag acgattcact 692761 tccgggacgc aataatatcc tgcgcaaaac gttaaatgac attctcatga agcatgccga 692821 ggcagtgggt gtagacatca agtgggggaa aaaggttgtc gcctatgaag aaactgctga 692881 atcggtcact gccttatgtg aagatggaga aaagatgcag gctgacattc tggcgggctt 692941 tgacggcatt cactccgttg ttcgtgataa gatgctgcaa aaggaaacgg aaaaagagca 693001 tctcggcatg ggagcgtggc gcttttatat cgaacttcct gattacacat tcgaggacgc 693061 aacattcatg tatagaagcg gagacacaca aatcggggtg gtgccattgg cacaacacgc 693121 tggctatgtc ttcgtcctcc agccttgcac gagcgattac tgggatgagg aagatacccg 693181 gtttgataga gtaaaagaga ttctttctgg ttttcggggg ctggattttg tcacaaagca 693241 catgtcaaaa cagcatcctg tcatctttaa caaactggag caggtcgccg tgcaggagcc 693301 atggcataaa ggccgcgtca tcatcggagg agacgccgcc cacgccggtg cgccaaccct 693361 ggcacaagga gcggcaatgg cgatcgagga tgccatcgtc ctcgccgaag aactccaaaa 693421 ccacgccgac cacgaaacag cattacaggc gtactataaa agaagagccc cacgagcgct 693481 caaagtccag aacctatcat ctgaaatcgt ccgccgcagg ctgaaaggag agccgggagc 693541 ggaagaactg attggggagt gctatgcggt gttgagggaa gggtattaaa taggaaaagt 693601 ccagaaagtg atttctggac tttttagtct tgctctgttt tattccttat ccgctcaatc 693661 acctcatgca gcccctcagg cttataaaac tccaccggtg aactgccttt ctcaaacgaa 693721 atcgtctcgg cttcaatcag cgcgacatag cgcccgttta cttttgcgag atgaatagaa 693781 tcgccaaaat ccgctagcaa tcccttaatc tctgtttctc cgactttcat tttcagctgg 693841 gcctctggcg tgtgctcgat gatttgggcg gaggcttcga tgacttgatg ggtgtcgagg 693901 cgctcttgga tttcccgttt ttcgcttgct tcccaaatct caatgtcgtg ctcgaactgc 693961 ttgagttctt cgctgttgtc ttcaaatgtc tcgtagacgt gctcttgtac catgttcatg 694021 acctgatttt tcatgatttc tggcatcgat tctccgtact cgacgaattt cagaaagtcc 694081 tcaaaatagc gggcgtgcga ggcctggtgg attttcagtt caccttcctc gaccattcct 694141 tcctctggca tgtacgggta ttggatgctt ttcatgtttt ttgtcgtgat cgccatttcg 694201 acttttttaa tgagagaaga cgcgtcagag atgcgggcga ccttcggctc aaaatcacat 694261 ttcataatga agacaaatga ctcatcaaag tattttctcg gcacggccga agcgacgaga 694321 aacacgccgc cgcgaaccgc gcttgtgtca aggtacgtgc ggacgaactg ctcgctcagc 694381 tcattgaagt cttcttttgt ttccgccaga cgcgcgcggt tgaacatgtt gtagtttggg 694441 ttggaatcga gctcgtggcc gggctcgacg ataaaatggc cgattttcgt cggcacctgc 694501 tcggactgcg gatggcggtc ggctttccgt ttaacgattt ttttcagttc cccgtcgaga 694561 aagtccttca gctcgctttc ttcaaattct cccgtatcaa gggtctggaa gtgcttgaac 694621 tgcttgttcg cctgctcatc tttgccttcc acctgtatga cataaaagga taaaaaccga 694681 atttcaaaat ccatatataa actcacctta ttcgcgtatt gtacagcttc tcaagtatag 694741 aaaaaacagc gatcatgcgt caattgggag aacggaataa tcatgaccat gaaagggaaa 694801 tgtagtcaaa tagaaggcat ttcatacgga aaggaatggt tcgatgaagg aaacaagccc 694861 gattcctcag ccgaagacgt ttgggccgct cggcaatttg cctttaattg ataaagacaa 694921 accgacgctt tcgctgatca aactggcgga agaacagggc ccgatttttc aaatccatac 694981 acccgcgggc acgaccattg tagtgtccgg ccatgaattg gtgaaagagg tttgtgatga 695041 agaacggttt gataaaagca ttgaaggcgc cttggaaaag gttcgcgcat tttccggtga 695101 cggattgttt acgagctgga cgcatgagcc taactggaga aaagcgcaca acattctgat 695161 gccgacgttc agccagcggg ccatgaagga ctatcatgag aaaatggtcg atatcgctgt 695221 tcagctcatt caaaaatggg caaggctcaa cccgaatgaa gcagtcgatg tcccgggaga 695281 tatgacccgg ctgacgctcg acaccattgg gctatgcggg tttaactacc gctttaacag 695341 ttactacaga gaaacgcccc acccgtttat caacagcatg gtgcgggcgc ttgatgaagc 695401 gatgcatcaa atgcagcggc ttgatgttca agataagctt atggtcagaa caaagcggca 695461 attccgctat gatattcaaa cgatgttttc gttagtcgac agcattattg cagagcgcag 695521 ggcgaatgga gaccaggatg aaaaagattt gctcgcccgc atgctgaatg tggaagatcc 695581 ggaaactggt gaaaagctcg acgacgaaaa tatccgcttt cagatcatca cgtttttgat 695641 tgccggccat gaaacaacga gcggcctgct ttcctttgcg acttactttt tattgaagca 695701 tcctgacaaa ctgaaaaagg cgtatgaaga ggtcgatcgg gtgctgacgg atgcagcgcc 695761 gacctataaa caagtgctgg agcttacata catacggatg attttaaatg aatcactgcg 695821 cttatggccg acagctccgg ctttcagcct ttatccaaaa gaagacacag tcattggcgg 695881 aaaatttccg atcacgacga atgacagaat ttctgtgctg attccgcagc ttcatcgtga 695941 tcgagacgct tggggaaagg acgcagaaga attccggccg gaacggtttg agcatcagga 696001 ccaagtgcct catcatgcgt acaaaccatt cggaaatgga caacgggcct gtatcggcat 696061 gcagtttgcc cttcatgaag ccacacttgt gttaggcatg attctaaaat atttcacatt 696121 gattgatcat gagaattatg agcttgatat caaacaaacc ttaacactta agccgggcga 696181 ttttcacatc agtgttcaaa gccgtcatca ggaagccatt catgcagacg tccaggcagc 696241 tgaaaaagcc gcgcctgatg agcaaaagga gaaaacggaa gcaaagggtg catcggtcat 696301 cggtcttaac aaccgcccgc ttctcgtgct gtacggctca gataccggca ccgcagaagg 696361 cgtcgcccgg gagcttgctg atactgccag tcttcacggc gtaaggacaa agacagcacc 696421 tctgaacgac cggattggaa agctgccgaa agagggagcg gttgtcattg tgacctcgtc 696481 ttataatgga aagccgccaa gcaatgccgg acaattcgtg cagtggcttc aagaaatcaa 696541 accgggtgag cttgagggcg tccattacgc ggtatttggc tgcggcgacc acaactgggc 696601 gagcacgtat caatacgtgc cgagattcat tgatgagcag cttgcggaga aaggcgcgac 696661 tcggttttct gcgcgcgggg aaggggatgt gagcggtgat tttgaagggc agcttgacga 696721 gtggaaaaaa agcatgtggg cggatgccat caaagcattc ggacttgagc ttaatgaaaa 696781 cgctgataag gaacgaagca cgctgagcct tcagtttgtc agagggctgg gcgagtctcc 696841 gctcgctaga tcgtacgaag cctctcacgc atccattgcc gaaaatcgtg aactccagtc 696901 cgcagacagc gatcgaagca ctcgccatat cgaaattgca ttgccgccgg atgttgaata 696961 tcaagagggc gaccatcttg gcgtattgcc aaaaaacagc caaaccaatg tcagccggat 697021 tcttcacaga ttcggtctga agggaaccga ccaagtgaca ttgtcggcaa gcggccgcag 697081 tgcggggcat ctgccattgg gccgtcctgt cagcctgcat gatcttctca gctacagcgt 697141 cgaggtgcag gaagcagcca caagagcgca aatacgtgaa ctggcgtcat ttacagtgtg 697201 tccgccgcat aggcgcgaat tagaagaact gtcagcagag ggtgtttatc aggagcaaat 697261 attgaaaaaa cgaatttcca tgctggatct gcttgaaaag tatgaagcgt gtgacatgcc 697321 gtttgaacga tttttagagc ttttacggcc gttaaaaccg agatactatt cgatttcaag 697381 ctctccaaga gtgaatccgc ggcaagcatc gatcacagtc ggtgtcgtgc gcggcccggc 697441 gtggagcggc cgtggcgaat acaggggtgt ggcatcaaat gatttagctg agcgtcaagc 697501 cggtgatgat gtcgtgatgt ttatccgcac accggaatcc cggtttcagc ttccgaaaga 697561 ccctgaaacg ccaattatta tggtcgggcc aggcacggga gtcgcgccat ttcgcggttt 697621 ccttcaagcc cgcgatgttt taaagcggga gggcaaaacg ctcggtgagg ctcatctcta 697681 ttttggatgc aggaacgatc gggattttat ttaccgagat gagcttgagc ggtttgaaaa 697741 agacggaatc gtcactgtcc acacagcctt ttcccgaaaa gagggcatgc cgaaaacata 697801 tgtccagcat ctcatggctg accaagcaga tacattaata tcaatccttg accgcggtgg 697861 caggctttat gtatgcggtg atggcagcaa aatggccccg gatgtggagg cggcacttca 697921 aaaagcgtat caggctgtcc atggaaccgg ggaacaagaa gcgcaaaact ggctgagaca 697981 tctgcaggat accggtatgt acgctaagga tgtctgggca gggatataga taaagaagac 698041 tggagacatc cagtcttttt agtcctttcg aaaaaatggt gatcgcgcta aacattgatg 698101 catacaataa cttcagtccg ccggaagggc gggctgtctg caaaacctat ttttcgtttt 698161 tgctagttta tgttattctt atactcggta tctatttctt ttttcaaagg cacacatgac 698221 aaaagaaatc ctttttttat ttccgagaaa aaaatgtgaa acgaaatgaa ggtttctttc 698281 gtccagtgat tggtttccaa atggttgtaa taaaaatgat atggtgcgaa acataaatat 698341 tccggcttgc cgcggtgtat ttattgttgt gtgatgcctt gattttgttt ggaaagaagg 698401 aattggaagg caggatataa agagcaggta aatatgaatg aagaacttaa agtgtttaag 698461 aaagtagagg ttgccatgaa gaaacttttt tcttacaaac ttagcttttt tgtgctggct 698521 gttatactgt tttgggcaaa aacgtattta tcctacaaga ctgagtttaa tcttggggta 698581 aaaggcacaa ctcaggagat cctcctgata tttaacccat tctcaagcgc cgtcttcttt 698641 ttaggactgg ctttgctggc gaaagggcgt aaatcagcca ttattatgct gattatcgat 698701 ttcttgatga catttgtgtt atatgcaaat attttattct atcgtttctt tgacgatttc 698761 ttgacgttcc cgaacattaa acagtccgga aacgttggaa acatgggaga cgggattttc 698821 agtatcatgg ccggtcatga tattttctat ttcttagata ttatcatttt gattgcggta 698881 ttgatctgga gacctgaatt aaaagaatac aaaatgaaaa aacgctttgc atctttagtg 698941 atcctttctg ggatcgcact gtttttcatc aacctgcact atgcggaaaa agaccgtccg 699001 caactgctga caagaacgtt tgaccgcaat tatattgtga aatatttagg tttatacaac 699061 tacaccattt atgacggtgt acagacggct caaacagaga cgcaaagagc ctatgcaagc 699121 agcgatgatt taacaagtgt cgagaattac acgacgtctc attatgcgaa accaaacgcc 699181 gagtacttcg gctctgccaa aggcaaaaat atcattaaaa ttcacctcga aagcttccag 699241 tcattcctga ttgactacaa gctaaacggt gaagaggtga cgcctttctt aaataaactt 699301 gcgcacggcg gggaagatgt gacgtatttt gataacttct tccatcagac aggccaggga 699361 aaaacatctg atgccgagct gacaatggat aactcgatct tcggtcttcc tgaaggctcc 699421 gcgtttgtga cgaaaggcga aaacacctac cagtcgcttc ctgcgatttt agaccagaag 699481 gaaggctata caagcgccgt cctgcatggt gattacaaat cgttctggaa ccgtgaccag 699541 atttacaaac atatcggata tgacaagttc ttcgacgcaa gcacgtatga tatgtcagat 699601 gaaaatgtga ttaatatggg gcttaaggat aagccgttct ttacagaatc gattccaaag 699661 cttgaatctc ttaaacagcc attttatgcg catttgatta cattgacaaa ccattatccg 699721 tttaaccttg atgaaaaaga cgcgtctctt aaaaaagcga caacaggcga taacacagtt 699781 gacagctact tccagacagc gcgttacctt gacgaagcgc ttgagcaatt cttcaaggag 699841 ctgaaggaag ccggcctgta tgacaactca gtcatcatga tttacggtga ccataacggt 699901 atttctgaaa accataaccg agcgatgaaa gagattcttg gaaaagagat cacagattat 699961 caaaacgcac agaaccagcg tgtgccgctg atgatccgcg ttcctggcaa aaaaggcgga 700021 gtgaaccata cgtatggcgg cgaaattgac gtcatgccga cacttctgca cttagaagga 700081 attgattctc agaaatatat caactttggt actgatttat tctctaaaga ccacgacgat 700141 acggtggcat tcagaaacgg agacttcgta acgccgaagt acacatcagt cgacaatatc 700201 atttacgata cgaagacagg tgaaaaactg aaagcgaatg aagaaacgaa gaatctgaaa 700261 acaagagtga accagcagct gagcctttca gacagtgtcc tgtacaaaga cttgctgagg 700321 ttccataaac taaatgattt caaagccgtt gatccgtcag actatcatta cggcaaggag 700381 aaagaaatca aataagatga aaaagagcct tgagcgggcg cattgccttc gctcaaggct 700441 ctttttttgg ttatacaacc aacttgaaaa aatagattcc atttggtcac caaggctggc 700501 tttctctcat atcattacag tagattttga aaccggattg aaatcggaca aattatcggg 700561 gaaatgcctt gatagattgt gaagatgtac caggtttcga actcaatatt catagagatg 700621 aggggtagag atgaaagcgg tcattctctg cggcggaaaa ggaacgagaa tgagtgaagt 700681 cacgaatgac attcctaaac cgctcgccat gataggcggc aaaccgattc tatggcatat 700741 tatgaaaatt tatcagtact acggagtaaa cgagtttatt ctgcttttgg gctataaagg 700801 agaaaaaatc aaggaatact ttctcgacta tgaatggaag cacaacagcc tgacactcga 700861 cagctctacg ggagaggtac agatgctggg gcagcctgaa acgtggaaaa ttacgttttt 700921 ggagactggg gtagatacgc tgacagccgg aagaatcttg caggcgaaag actatatcgg 700981 tgatgaaaca tttctgctca cctatggaga cgggctggcc aatatcaatc ttttccatct 701041 catcagctat catcagacaa aaggtgctgc cgcgactgtc accggcattg acaaagtctc 701101 gcagtttggc accttgacag ttgaggatgg catggcgaaa acattttctg agaagacatc 701161 aagtgatgga atcatcaacg gcggattctt cgttcttagt ccaaaggttt tcgattattt 701221 gccgaaggac gggaacacga tgttcgaaga tgaaccgctg aagaaccttg ccaaagatgg 701281 ggagcttgct gtgtaccgcc attacggatt ttggacggcc atcgatacgt ataaaaatct 701341 cttagaagtc aacaaaatgt ggaatcaagg acaacaagta tggaaggtat ggtgaattga 701401 tttgagtttc tggaaaaata aaaacgtatt tgtcacggga tgcacaggtc ttttaggaag 701461 ctatttggtg aaagagctga tcgaacaggg cgcaaacgtt acggggctag tcagggatca 701521 tgtgcctcaa tccaatcttt atcagggaga acatatcaag aaaatgaaca tcgtgcgggg 701581 ctctcttgag gacttggctg tgattgaacg cgcgcttggc gagtatgaga tcgacacagt 701641 ctttcatctt gctgcacaag cgattgtcgg cgtggcaaac cgcaacccga tttctacctt 701701 tgaagcgaat atcctcggca cctggaatat tctcgaagcc tgccgcaagc atccgttaat 701761 taagcgggtc attgtcgctt caagtgataa agcttacggc gatcaagaaa accttccata 701821 cgatgaaaac atgccgctgc aaggcaagca cccgtacgac gtctcaaaaa gctgcgcaga 701881 tctgatcagc cacacctatt ttcacacgta cgggcttccg gtctgcatta cgcgctgcgg 701941 aaacttatac ggcggcggag atttgaactt caaccgcatc attcctcaga cgattcagct 702001 tgtgctgaac ggggaagcgc cggaaatccg aagcgacggc acatttgtac gggactactt 702061 ctatattgaa gacgccgttc aggcttatct gcttcttgca gaaaaaatgg aagaaaacaa 702121 tcttgccgga gaggccttta acttcagcaa tgagatccag ctgaccgtac ttgaactggt 702181 agagaaaata ttaaagaaaa tgaacagtaa tctgaaacct aaggtgctga atcagggaag 702241 caatgaaatc aaacatcaat atttatccgc ggaaaaagca agaaagctgc tgaattggac 702301 accggcctac actattgatg agggacttga aaaaacgatt gagtggtata cggaattctt 702361 caaaaagtaa tgtgaaacga ggtgaacaag actgtgacca gcgcgtattg caccgtttta 702421 tcaaaaggaa gattatatca ggcagtcgct ttgtttaagt cgttagagca agttgatcaa 702481 gacagtccca tttttatact ttgcatggat gaagatacgc accgcgtgtt acagaagctg 702541 aagatgaagc agctgaacct tgtgccggtg gccgctcttg aaaatgaatt gctgctgaag 702601 ctgaaggaaa ctagagatca aagtgagtat tgctggacga tgaagccgat ctttctgcaa 702661 gctgtgctga acagcaatcc tgagctggag cgtgtgacgt atattgacgg ggatctcttt 702721 ttctatgcag atccatcgcc gatttttgaa aaccagccgg actgctcggt gttgctttca 702781 cgaggggata ttgtaatccc ttcttttgag aaagagcaga ttgacatgct gcagcgtctt 702841 ttaggcagat ataattccgg gtttatcagc ttcaagcatg atgatgcagg cacggattgc 702901 ttggagtggt ggaaggaacg ctgtcttgag gaatgcaaaa atgcaccggg tgaagggaaa 702961 ttcggtgatc agggctattt ggattatatg tctgagctgt ttccgaatgt gtgtgacatt 703021 acaacacccg gcgtgaacat cggccattgg aattatggac agcatacgtt ttcctggaaa 703081 gatggccgga tcgtgctgga ggatggcagt ccgctgatct tttatcattt cagcggatac 703141 cgaatcgtca gcatcaatga aatcaaacag attcatgaaa caacccgcac agatctgccg 703201 tttgtgcatg aactgtatca agagacactg ccgcatatca ttcagcacat gcaaacgtta 703261 gaccctgaat ttaacggttt tgcttcaaaa gatgacaaca aataaatgag taaatacagg 703321 aagtgaaaat gaagtgaaag caagcgttat tattcctgca tataattcga aggagcgtct 703381 ttacaacagc cttctgtcat taaaccagca ggagtgcgat gaagaatttg aagtcattgt 703441 agcggacaat ggctctgagg acgggacgct ctcgatgctt gagtcatttc aagctgattt 703501 tccgctgatc tttacacgga ttaaagaaaa caggggcatt gcgtacggac gaaatcaggc 703561 gcttcgcaat gccagaggag acatcctgat tttccatgac agcgatatgc ttgcggcaaa 703621 ggaccttgtg gcaaaacata ttaaagccca tgagaacgaa gagaatctcg tcgtgtgcgg 703681 gttgttttgg aaacggatct acagttttta ctatgaacga tttgaagaag aacataagga 703741 acagctcgca aagctcacag gtgaaatgcc gaagaaagac aaacaaaagc tgctggagga 703801 agcggacatc aaaaacggaa gctttcttga taaaagcttt gacctcgata ccgactttat 703861 agacgtgctc aagaagattt tagatgagta cggcgatgac ttgaaaggct atcatatgcc 703921 atggcgcttt tttatcacga ataattcctc tgtgaaacgc aagcatgtgg ttgacctcgg 703981 tttatttgac gaaggcattg tgcggtacgg gtttgaggat tatgacctcg ggatcaggct 704041 tcatcaggcc ggattgacct tcaggcttcg ccgtgatatt gtcagtgttc atcaggaaca 704101 tccaagcaat tgtaagtctg tagacgatat tcgggcaaac attgcctata tgtgcgataa 704161 atacaataac atccgctcct tagacgttca tctcgctttt aatgggccgt tcccgcctga 704221 catgacgaac agaatcatgg ctgatattca aaagctgctg gaatcacaga aatatgatat 704281 gctgctgaat ctgtttcttg agcttctgca tgttgttaaa gagcgcaaca ttgatccgga 704341 ttggcgaaag aaatccccaa gggtgacggc gaaaagcttt gatttgcaaa ctgtccgcaa 704401 gcttctgcct aaggcgaaga aaaagctagg cgtgaacgat tttgccaacg cactgtatgc 704461 gcttgtcaac gatttgctgc acgtggatct tagatcattg gatgtggtat aagtgagtac 704521 atttcatttt tcaacgatag tgtcaaggac acatatcttt aagctcatgc ctatgattca 704581 ttctctccat gagcattgcg atgattttca tttatatgtg ctgtgtgtcg accagaaagc 704641 gtatgaattg cttcagcacg ttccatggga gcatgtaacc tttgtgcagc tgcatgaaat 704701 ggaagacccg gagctgttga aagcgaaaag caacagaacg tttcatgaat attgctggac 704761 gttaaagccc gcctttttgt ttcatgtgat gagcaagtgg gatgacgctg aatactttgc 704821 ccatatggat acggatctat ttttcttttc tgatccggca cgtatttttg cagaaaaccc 704881 aacggcgtct ctgtatttga ctgatcatcg taattcgccg cgcttcatgt cctactacga 704941 ccgaaccgga cgctttaata caggctttgt cggcgccggt aatacaaagg aagcatatga 705001 agcggtgtgg cagtggagac aggactgtat tgaattttgc acggtcgaaa tggatacgga 705061 acgaaagaca tatggtgatc aaagatatgt ggagaaatgg ccggagcagt ttaaaggtgt 705121 tcatgttgtc aaatccatag gagccaatac agcgctttgg aatatcgaaa actataaggt 705181 cgggcaaaag gacggccgcg tgtatataga tgaaacgccg ctgattttct atcatttctc 705241 tgggtttacg ctggtgacag aaaaagagtt taatctttgc tggtactacc ggattgaaga 705301 cgaagcgaca attaagatga tttatatgcc ctatatatta aatctgaaaa gatggattga 705361 tgaaatacag tcggcgtttc cggactttgc ggatggcttt atcccgaagc acgcagtgcc 705421 tgacactcat tttatccagc tggattaaaa aaccccctgc cgcctggcag gggttttttc 705481 agctatgcca ttctctcagc ttctggtcac ttggcaatag gaaggcaagg atgccgagga 705541 cagggagaaa ggcaatggcg atcatcgtcg gggtcagtcc cgcggcatca atcagagcgc 705601 ccagcgccac agcgccgatt gcgcccatcc cgaaggcaag cccgacggtt aaaccggaca 705661 ttgtgccgat ttttccagga actagctcct gtgcgtagac gaccgttaca gaaaagctcg 705721 acatcagaac caagccaatc aatgcgagca cgccgtaggc gagaaccggg ccggcaaatg 705781 gcagcacaat cgccagcggc gccgagcata acagcgaacc gaggataacg aagcgttttc 705841 caaaacggtc tgcaagcggg ccgccgagaa acgtgccgat cgcgccgaac agcaagaaga 705901 caaaaatata gctttgtgcc tgctgaatgc ttacgtgata ggtatccatc gcgtaaaacg 705961 tgtaaaagtt accgatcgca ctcgtatacc aagaacgagc aaaaatgaga aatataataa 706021 taataagagc agatacaaca gatttggtga tggccgtgtt ttcagccgtt ttcttttgct 706081 tgcctgattt ctgggcaagg ctgccgagac gtgaggcgta ccatttcgca atatacatga 706141 gaaacataac agcaagcgcg gcgacaagcg tgaaccaaac agcgccgaat tgcccgagcg 706201 gcacaaggat cagcgcggtg atcagcggtg ccatcgcctg gcctgagttt ccgcccacct 706261 gataaatcga ttgggcgagc ccgcgttttg tgccggcggc catatacgcc acacgggagc 706321 cctccggatg gaaaatggcc gagcctaatc caatgaaaaa cacacagcat aagatcgtta 706381 tgaatgacgg ggcaaatgca aggcccaaaa tgccaagcat gctggcggtc aaaccgactg 706441 gcagcgcata cggccgcggc cgtttatcgg tataccagcc gacaacaggc tgcatgacgg 706501 atgacaccat gtttaatgtg aaagcaatga tgccgagctg tgtaaacgtc aggctcatgg 706561 agcgttccaa aatagggaac atggccggaa tcacagcctg aagcgaatcg ttgagcatat 706621 ggcaaattcc gataataatc aaaatcggat acaccgtggt gcctggtttt tgaactgttt 706681 tttcttttaa cggggcggcg atagccattg agtctcctcc ttacatatat aaccaaagca 706741 taccaccata ttattcataa ggtgaagaat ttatcaagag gaaaaaagat tcttatgaaa 706801 gaaataccgt cagcctgatt agcagctgac ggtattttcg atattcaaaa tgtgatatag 706861 ctcttcaagc ttacgaatct cataggttgg tatgatctct ggcacattcg gcttcatgtc 706921 agggttcatc cagcaagtat caagcccggc gagctgtccg cctttgatat cagcagttag 706981 tgaatccccg atgattaatg tgtgctctgc tgaaaattga ggaatccgtt caaacacgta 707041 attgaaatat tccttcatcg gcttttggaa gccggtgtct tcagaaacga aaatgtcctt 707101 gaagaatgga aataatcctg aatcacggag acgcttatat tgtgtgtgag acacgccgtt 707161 tgtcacgatg tacaaatcaa actgttgctg cagatttgag atgagatcaa atgcaccgtc 707221 aataagctga tgtccttctt caagaaagcg gcggtatttt tgctcaagca aagcgccgtc 707281 cgcttcgtaa ccgtactcct tgagcaaagc ggaaaaacgt gtgtttacga cttcatcccg 707341 tgtcatctta ccttcttcaa aggctctcca gagaccttga ttgatggttt tatactgcgc 707401 cttcatgtca tttgttaaag gaatgttctg atcttcaaac agcaaacgca gggctaaagc 707461 ttctgccgct tgaaaatcaa ggatggtatc atctacatca aataataaag tgcggtatcg 707521 cttcatctgt gtgtctccct ttctcatatg tattcaaagt atagcacata aaaaaaggaa 707581 aaagccggcg ggtgaggcac cgccggctga aaagagatta tttgtttaat aagctgtgtt 707641 ttctcgaata taggaagtaa accagcgttc cgacagcgat ccagatgaca aatgaaagcc 707701 atgtgacgcc gggaaggctg tacatgaacc aaaggcagat gcctgcgctg ataatcggca 707761 caaccggaac gaatggcact ctgaaggacg ctttgatttc aggatgtttc tttcttaaca 707821 caatgacagc aatggaaatg accgtaaacg cggcaagtgt tcccatgttc accagatggg 707881 ccagcgttcc gaggttaata aagccggcga ttcccgctgc aacgatccct gtcagccatg 707941 tgttgcggaa cggggtttta aatgacggat gaacctttgc gaacaatcca ggcagaaggc 708001 cgtctctgct catggcaaat gtcaagcgga cctgtgcgta cagcaaagcg agcatcaccg 708061 tcgtaatccc gataatcgca ccgacagaaa taattccggc aacagcgtcc tgtccgacga 708121 atttcagcgc aaaggataca ggatctccga cattcaattt ggcataaggc atcatgcctg 708181 tcagcacaag cgataccgcg atgtacagaa ccgtacagac ggctagagct gaaataatgc 708241 cgacgggcat gtttttttgc ggatttttca cttcctctga tgcgttagaa accgcgtcaa 708301 acccaaggta cgcgaagaat acagtggcag cgctaagtat gacgcctttc atcccgaatg 708361 gcataaaagg agaccagtta tccggtttca catagccgat gccgacaata atgaacaata 708421 atatgatcgc gattttcatc agtacgatga cgttgttaaa gcgtgtgctt tccttgacgc 708481 ctctgctgac aatcgcagtg atgaggagaa tgatcaccgc agccggaagg ttaaatacgg 708541 cgcccgccat gcttcccggc gctcctgtca gtgcagccgg aatatgaaga ttgaagccgg 708601 caagcagtga ttgaaagtat gaagaccagc cggtggcaac cgccgacagt gcaatgacat 708661 attcaagcat gagatcccat ccgatcaaaa aggcgagcag ctctccaagt gtcacgtatg 708721 agtatgagta cacgcttccc gaaatcggaa tggaagacga aaactcagca taacagaaag 708781 cagccagcgc acaggcgagc cccgctaaaa taaacgatat gatgagggcg ggacctgcac 708841 cggtcgctgc cactgttcct gtaatgacaa aaatccctgt accgatgaca caaccgatac 708901 cgagcaaggt taaatcaaat gcgcttaacg tacgggcaag gctttttgac ttgctctgcg 708961 cactcaatgt ttcaagcggt ttttttctaa ataatgaact catcaaaagt tcctcctaga 709021 aatattcaaa atattctaat cattatatgc agttcttgtt gtattatatt gtcgaaattt 709081 gacgtagtca ataaaatatt tttctgcttt aaatgataga agcgaaacag cgttgtcgta 709141 tcataggata gtaattttta ctaatcgtat attcaatttt atgcaagatg aaccgataga 709201 aaaaatagat tcgcccatat tttgatttgc ggttataaag gagatgctga ccatgtttca 709261 atatgaagag ttgaataaac agtttatcgg cgggaaatgg caggagggca gcagcccaaa 709321 tgtattggaa aacaaaaatc cttatactca aaaaacattc acaacattcc gtaaagcgac 709381 tgctgacgat gtagatgaag cgtatcgggc agcggcgctg gcaaagaaaa aatgggatgc 709441 ggtcaacccg ttcgagaaaa gaaccatttt agaaaaagcc gtcacgtata ttgaagaaaa 709501 tgaagaagcc attatttatt tgattatgga ggagctaggc ggtacaaggc tcaaagcagc 709561 ttttgaaatc ggtcttgtca aaaacatcat aaaagaagcg gcaacgttcc caatccgcat 709621 ggaggggaaa attcttccgt caacaataga tggcaaggaa aacagattat atcgcgtgcc 709681 ggcaggcgtt gtcggtgtca tcagtccgtt taacttccca ttctttttat ctatgaaatc 709741 agtggcgcct gcactcggag ccggcaatgg cgttgtgcta aagccgcatg aggaaacgcc 709801 gatttgcggc ggaacgctga ttgcgaaaat ttttgagaac gcgggaattc cagcggggct 709861 gctgaatgtt gttgtcacag acattgctga aatcggcgac agcttcgttg agcatccagt 709921 gccgcggatc atctcattta ccggttctac gaaagtcggc agctacatcg gacagcttgc 709981 gatgaagcat tttaaaaagc cgcttcttga gcttggcggg aacagcgcct tcatcgtact 710041 tgaggatgca gatatagaat atgcggtcaa tgcggcggtg ttcagccgat ttacacatca 710101 agggcagatt tgcatgtcag ccaaccgcgt gcttgttcat tcttctattt atgacaagtt 710161 ccttgagctg taccaggcaa aagtggaatc gctgaaagtc ggcgacccaa tggaccctga 710221 tacgattatc gggccattaa tcaacagcag acagacggac gggctgatga agactgtaga 710281 gcaagcaatt gaagaaggcg ctgtaccagt gaagcttggc ggatttaacg ggacgatcgt 710341 ggaaccgacg atcttaaaag acgtcaaacc gttcatgagc attgccaagg aagagctgtt 710401 cggaccagtc gtctccttta tgaagtttga ttcagaagac gaagcggtgg atatcgcaaa 710461 cgaaaccccg tttggcttga gcggtgccgt acatacgtca aatcttgagc gcggcgtggc 710521 ttttgcgaaa cgcattgaaa caggcatgat tcacgtcaat gacacgacca tcaatgatga 710581 accgaatgta gccttcggcg gtgaaaagca atcaggcctc ggccgtttaa acggtgagtg 710641 gagcctcgaa gaatttacaa cgctgaaatg gatctcggtc cagcacgaaa aacgcagctt 710701 cccttattaa tgaaaaggag tgaatggaat tgaccataaa tacggaaaaa gaaaccgcag 710761 atattctgga cgcatttatc aaagtagccc cttatttaaa cagcctggtt caggatgata 710821 ttacaatcgg catttatgat acggaaaaac tgctcgtgaa tataccggcc aaaacctttt 710881 cgctgaacgt aaaagccggc gatccgctgc aggaagggga tatcatcaca gatgccatcc 710941 gcagcaatca gaagaagacg agcatggttc cgaaagaatt gttcggcttc ccattgatcg 711001 cgcgtgccat cccgctgcac gacgagaatg gaagagtcat tggaggcgtc ggcctcggaa 711061 cgagccttga ggagtcgtca aagctgcatg atgtcgcgga aagcttatca gctgttgttg 711121 aacaaacagc cgcggctatt tccgacattt ctgaatcaat taacgggttt tcaactcaaa 711181 tgtcgggcat ttcctctcag gcgaaaaaag taagcgaaag cgccggtgaa atcgccgata 711241 tttcagtaac tgttaaaggc atctcggacc aaagcaatct gctcggcttg aacgccgcga 711301 tcgaagcggc aagagcaggg gagtccggaa aaggattctc tgtcgtcgca gatgagatca 711361 gaaagctagc gacgcattca aaagaaaatg tcggccaaat tgaccagatt acgaaaaaaa 711421 tccacagcct gctgaaaggg ctggaggaat ccattgagtc gattaaccag catacagacg 711481 gacaagccgc tgctgttgaa caaatttccg ccacgatgca ggagatttca ggaagcgcgc 711541 agcatcttgc gaaaatggcc gaaaaagcgc ttgaggaaga gtaagagacc ggggacaaac 711601 atccccggtc tttttcttat cctgcatttc catgaaattc gtctgacgtt ttactagttt 711661 tattccagcg gctgatttaa aatgtacaca tgaacttacg tgaggattga taggaaccat 711721 gagcatatta aaagcggaaa atctttataa aacatacgga gataaaacat tatttgacca 711781 tatctccttt catattgaag agaatgagag aatcggatta atcgggccga acggaacagg 711841 aaaatcaacg ctgttgaaag tgattgccgg cttggaatct atcgaagaag gagaaatcac 711901 gaaatccgga agcgtgcagg tcgaatttct tcatcaagac ccggagctgc ctgcggggca 711961 aacagtgctg gagcatatct attccggtga atcggctgtg atgaaaacct tgcgtgaata 712021 tgaaaaagcg ctgtatgaac tggggaaaga tcccgaaaat gaacagcgcc agaaacacct 712081 gctggcagca caagcgaaaa tggacgcgaa caatgcatgg gatgcaaaca ccttggcaaa 712141 aaccgtattg tctaagctgg gcgtcaacga cgtaacaaaa ccggtcaatg agctctcagg 712201 cggccagaaa aaacgggtgg ccattgccaa aaacttaatt cagcccgctg atttgctcat 712261 tttggacgag ccgacaaacc atttggataa tgaaacgatt gagtggcttg aagggtattt 712321 aagccaatat cccggcgccg tcatgctggt gacgcacgat agatatttct taaaccgtgt 712381 caccaaccgc atttatgagc ttgaaagagg cagcctctac acttacaaag gcaactatga 712441 agtgttttta gaaaaacgcg cggaacggga agcgcaggct gagcaaaagg aaacgaagcg 712501 gcaaaacctg ctgcgccgcg aactggcttg gctcagacga ggagcgaaag cccgctccac 712561 aaaacaaaaa gcgagaattg accgggtaga gacgcttaaa gagcagacag gccctcagtc 712621 atcaggttca ctcgattttg ccattggctc gcaccgtctc ggaaaacagg ttattgaagc 712681 ggagaacgtc atgatcgctt atgacggccg catgctcgtc gaccgtttta atgaacttgt 712741 cataccaggt gaacggatcg ggatcatcgg gccgaacggc atcgggaaaa caacgctgtt 712801 aaatgccctt gccggccgtc atacgccgga cggaggcgat attacgatcg gacagacggt 712861 cagaatcggc tactatactc aggatcatag tgaaatgaac ggtgagttaa aagtcattga 712921 ctatataaaa gaaacggcgg aggtcgtaaa aacggcagat ggcgatatga ttacagctga 712981 acaaatgctc gagcgtttcc tcttcccgcg ttcgatgcag cagacgtata tccgcaagct 713041 gtccggcggg gaaaaacgcc gtttatactt gcttcaggtt ctcatgcagg agccgaatgt 713101 cctgtttctc gatgagccga cgaacgattt ggatactgaa acattaagcg ttcttgagga 713161 ttatattgac cagttcccag gcgtcgtcat caccgtatcc catgaccgct atttccttga 713221 ccgcgtcgtc gaccgtttga ttgtatttga aggaaatggt gtcatttccc gctttcaagg 713281 ctcctatagc gactatatgg aggagtcaaa agcgaaaaaa gcggccccaa aaccggcagc 713341 tgaggaaaaa acggctgaag ccgagccgaa gaaaaaacgg aaaaagcttt cttacaaaga 713401 ccagttggaa tgggacggca tcgaagataa aattgcccag ctggaagaaa agcatgaaca 713461 gcttgaagct gacatcgccg cagcaggcag tgattttggc aaaatccaag agctgatggc 713521 cgagcaggcg aaaacggcgg aagagcttga ggctgcgatg gaccgctgga cagaattgtc 713581 cctcatgatc gaagaactgg aaagctaaaa agcgtggccg cagcaggccg cgcttttttt 713641 cacataatgg acaaaaacga accggcctgc ttatgttagg ataaagttgt gtgtcagcgg 713701 cacatggaaa actaacggag atgatgaagt atgacatggg cgatcgtgat gttaattctc 713761 atgagtctgg tgaaaatcgt attaacctgt cttcctacag gcgtcataga atggctgctc 713821 ggcaaatttg aagtgcacgc caagctgagt gacgaaaatg cgagtctctc tctagatgga 713881 aaacgcctcg agggtgcaga gaagcagaaa gtgattgatc aatttaacga agctatcttc 713941 ctggaaaaat attatatcta tccaggtgat gaagagcgtt atttacatcc ggaaaacggc 714001 ggcacgcctc tggtgataga tacaaaaaaa ggaaaaaaag acgtgaagct gttcgtgtac 714061 cgctacgacg accatatcga cgtcgtgaaa cagtacaaga agaaagtgat cgcgtatcga 714121 gtgctttctg aaagccttca aaaagagtct ctgtcagtgg cgggaagttt agcttaaaca 714181 ggaaagtgaa agacgggtgc tgtatgctgc tcgtcttttt tattgttttt taaaacttaa 714241 cgtttacgtt aaggttcaaa aggtgtataa tggtaacaga aacggcgaag ggggatttac 714301 cttggaatgg atgaagattg atcaagtggc caaaagaagc gggctgacaa agcggaccat 714361 ccggttttat gaagaaatcg gcttgattcc ggcgccgaaa cggacagacg gcggtgtaag 714421 gctttattca gaggatgata tggaggagct tgagaaagtc atcagcacaa aagaggtgct 714481 cggtttttcc cttcaggagc ttcagcattt catggaaacc agccgccagc tagagttaaa 714541 caaagagggg tatttgttgt cactggatcc taaggaacgg aaagaaaaac tggaggaaat 714601 tcaggaaacc ctgaatcacc agctggattt gattgatgag aaaatccgca cattccaaag 714661 ctttaaagaa cgcctgcagg gcatgaaagg caaagcggaa cgcgccattc aatcaatcga 714721 atgaaaagtt tgttaaacgc tatttttgta gcgtttcttt taatggaata aagatggagg 714781 ttaggtcaaa tggataagac aacacaagtg aatcagaaaa cgggtttgct cagccagcca 714841 aaagcggtat gggctgtcgc gtttgcctgt gtgatttctt ttatgggaat cgggctggtc 714901 gatccaattc ttccggccat tgccgcacaa ttgcatgctt cacctagtga agtatcactc 714961 ttgtttacaa gttatttgct tgtaaccgga tttatgatgt ttttctcagg agccatttcc 715021 agccgcatcg gcgcgaaatg gacattaatt ctcggactta tttttattat tgtgtttgcg 715081 gggcttggcg gcagctcaag ctcaatcgct cagttagtcg gctatcgcgg cggctgggga 715141 ttagggaatg ctttgtttat ttcaacagcg cttgcggtca tcgttggcgt gtcagtcggc 715201 ggcagcgccc aagcgattat tttgtatgag gccgcgctcg gtctcgggat ttctgtcggg 715261 ccgcttgcag gcggagagct cggaagcatt tcatggcgcg caccgttttt tggagtatct 715321 gtcctgatgt ttattgcgtt aatcgcgatt tctttcatgc ttccgaagct gccgaaaccg 715381 gcgaaacgcg tcggtgtgtt tgatgcgatg aaggcactca aatataaagg cctgctgaca 715441 atggcggtat cggcattcct atacaacttt ggatttttta ttttgctagc ttattctccg 715501 ttcgtactgg atttagatga acacggtctt ggatatgtct tcttcggctg gggccttctg 715561 ctggcgatta cgtcagtctt tacggcgccg ctcgtgcaca aagcgctggg cacagtgcgt 715621 tcgctagtcg ttctctttat cgcctttgcg gccattctcg ttattatggg gatctggaca 715681 gaccatcaga ctttgattat tacatgtatc gttgtcgctg gtgctgtcct cggtatggtg 715741 aatacgatca tgacaaccgc tgtgatgggt tctgcgccgg ttgaacgttc aatcgcgtct 715801 tcagcctaca gctcagtccg cttcatcggc ggcgcgctcg ccccgtggat tgcaggaatg 715861 ctgtcagaac actttactgc aagcacacca tatacagtag gcggaatcgt cgtttttgtc 715921 ggcatgcttg tccttctcat gggacgtaaa catcttgctg gaattaaggc ggggcattaa 715981 taacgaaaga cactgcgcat atgcagtgtc tttttattcg ttataatgca tcataatcga 716041 attggtgcag gaaaggacaa cctttatgac acaattttac tattttccgg ctgaaaactc 716101 cctttagaaa ccggtttttt cggtcagcaa gaacggcgtt cgcggaaagg gcatccgctt 716161 cggtcaggca ttgatgcggc tgggatttat cttgcagaag ctgagaatgt gtccgttcat 716221 ttacgattgc catttcagtg atggttcatg ctgtagaggg gacgtttgcc atggataagg 716281 caaaacctga cgaatatgat cagaaatgtt tagaaacgct ctatcaatac atacacagcg 716341 tcatgaaaaa cagcttttct cggtcgagtg gtttaccgct tgggaagatg aggaggattt 716401 tgagctgtct gccaaaagag agctgacact tgatgaattc acatctccat tgcagctcat 716461 tttaaaagac agagagcttt tgagaatcgt tcagaaaaaa tggcagtaaa aaacccgccc 716521 tttagcaggc gggttttttt ataaattaaa gcactttcgt cgtccaagac tcgcagttcc 716581 acgtttctgt cgcaatatcc atataaaagt ctggctcgtg ggaaatgagc agaatggagc 716641 ctttatattc tttcagggcg cgcttgagct cttccttggc atcggcatcc aagtggtttg 716701 tcggctcatc gagcaccagc aggtttgttt ctgagttgat tagcttgcac aatctgactt 716761 tcgctttttc gcctccgctt aatacggaga cgcggctttc gatatgcttt gtcgtcagcc 716821 cgcattttgc cagagcggca cggatttcat actgcgtata agaagggaat tcgctccata 716881 cttcttcgat gcacgtattg ttgtttgttt ccttgacctc ttgctcgaaa tagccggtat 716941 agatgtgctc accgcgttca acagagcctt cgagcggctg gatttcacca agcaaacttt 717001 tcagcaatgt cgtttttccg atcccattcg cgccgtaaag ggcgattttt tggccgcgct 717061 ccatgcggag gttgagcgga cgggacagcg gggaatcgta accgatcacg agatccttcg 717121 tttcaaaaat cagcttgcct gacgttctcg ccggcttaaa gtggaattcc ggctttggct 717181 tttctgccgc aagctcgatc atatccatct tatcgagttt cttttggcgg gacatcgcca 717241 tgtttctcgt gctgacacgc gctttgttgc gggcgacgaa atccttcagc tccgcgactt 717301 cctgctgctg ctttttgtag gccgcttcaa gctgctgttt tttcacctcg tagacttcca 717361 taaactgatg gtagtcgccg acataacgtg tcagctcttg attttcaacg tgataaatca 717421 ggttgatgac actattcaag aacggaatat cgtgggaaat caggatgaac gcgttctcgt 717481 attcctgcag gtagcgtttc agccattcaa tatgctgttc atcaagatag ttggtcggct 717541 catcgagaag cagaatttcc ggcttttcaa ggagaagctt agcgagaagg acctttgtgc 717601 gctgtccgcc gctcaaatcg gtgacatctc gctctaaacc gatatcgctc aaaccgagac 717661 cgcgggcgat ttcttccacc ttggaatcaa tgacataaaa atcattgttt gtcagcgcgt 717721 cttgaatgac gccgacttct tcaagcagct tctcgagctc gtcgggatca gcctcgccca 717781 ttttgttgta aatctcgttc atttcctctt ccatcgcaaa taaataatgg aatgcgtctt 717841 tcaggacgtc gcgaatggat tttccttttt ccagcacggt atgctgatca aggtatccga 717901 cacggacatt ttttgaccat tcgacttttc cctcatcagg ttcaagcttt ccggtaataa 717961 tattcatgaa ggttgatttt ccttcaccgt ttgcgccgat caagccgacg tgctcgcctt 718021 ttaacaggcg gaaggaaacg ttattaaaaa tggcccggtc cccgaaaccg tggcttaaat 718081 cctttacaga taaaatactc atgtttacac ctctatcgtt atcaaacacg cacaatcggc 718141 gtgtaatatt cacccttttg attataaagg aggattcgga atgttgaaag gtataggaaa 718201 gaaaaagaaa aattgcgttc cgggcgaggt tttgagatac tatggaatag atttcaggaa 718261 ttgaggagaa caaaatgacg caaacttggc catttttaca taatgcacaa tcatttatac 718321 aagagaattg gaatgcttcc ggctttcaaa agccaacccc tgttcaggag caggcagccc 718381 agctgatcat ggacggaaag gatgtcattg cagaatcgcc gacaggcaca gggaagacgc 718441 tggcgtatgc gctgccggtc ttggagcgga tcaaaccaga gcaaaagcat ccgcaggcgg 718501 tgattttagc gccttcccgt gagctggtca tgcagatttt tcaggtgatt caggattgga 718561 aagcgggctc agagctgcgc gcggcttcct taatcggcgg ggcgaatgtg aagaaacagg 718621 tcgaaaagct gaagaaacat ccgcatatca tcgtcggcac gccaggcagg gtgtttgaac 718681 tgattaaagc gaagaaactc aaaatgcatg aagtgaaaac gatcgtgctt gatgaaacgg 718741 atcagctcgt cctgccggag catcgcgaaa cgatgaagca aatcattaaa acaacattaa 718801 gagaccgcca gcttctatgt ttttctgcca cgctcaaaaa ggaaacagag gacgtgctcc 718861 gcgaattggc gcaagagcct gaggtgttga aggtgcagcg aagcaaggcg gaggcaggga 718921 aagtgaagca tcaatacctg atttgcgacc agcgcgacaa agtgaagctg ctgcaaaagc 718981 tgtcaaggct tgaaggcatg caggcactcg tatttgtgag agacattggc aacctgagtg 719041 tatatgcgga aaaactggca tatcaccacg ttgaactcgg cgttttgcac agtgaagcga 719101 aaaaaatgga gcgagcgaaa atcattgcca cattcgaaga cggagagttt cctcttttat 719161 tggcgactga cattgccgca cgcggtttag atattgaaaa cctgccatac gtgattcatg 719221 ctgatattcc agatgaagat ggctatgtcc acagatcagg acgaacaggc cgggccggaa 719281 aagaaggcaa cgtgctgagc cttgtgacaa aattggagga atctaagctg aaaaaaatgg 719341 cgaagaagct tggtgttgag ctgagtgaag ctgtgtatgc aggcggaaaa ctgaagacga 719401 aataaaaaga agggcgaaga gccctttttt tgttgtaaaa taatagaaaa gattttgcgc 719461 ggaggtggga aaatggcttc aatagacagg tttcaagtaa tgcaggagcc agagctgaaa 719521 atccttgaac actggtttga gaatgaggat accagacgga gaatggatgg gatgctgcta 719581 ttagatgagt ggtatgcacg agtaaataaa gataaacacg atactgtcat catggcgtat 719641 gatggacagc tgccggcagg gatggtcgtt attgagttcg gagaggagcg gacatatatt 719701 ggattgatcg tcaatccttt gtaccggctt aaagggtatg gaaaacagat actgcaaaag 719761 ctgatgaccg aacctgattt tactagcgtg cgagaatggg tggcatgcat tgaagaagac 719821 aatcgaatca gtttagcttg ctttcaagca gcaggattca ctttagaaga cacggaacct 719881 gatgaagatg gttttcttac gctgattctt cgcaactgat ctcatcgaaa cacaaaagga 719941 gggcaaaaag ccctcccgtt ttcatcttca ttcagctcgg atcactgacc ttgatcagct 720001 gtttcccttt attttctccc ttaaataaac cgagaaacgc gtcaggaatg ttttcgaagc 720061 cttctgtgat ggtttcctcg taatggagtt taccagcctt cagccattct gccagctgtt 720121 ttgctccctc agaaaaacga tcggagtagt cgcttacgat aaagccttgc atcagcgact 720181 tcgttttaat gagttttgat tggacacgag ggcccatgtc atctgcttcg ctttctgcgt 720241 tataggaaga aatggcgccg cacaccggaa tgcgggcaaa ttcattgagc agattcatca 720301 ccgcgtctga aatcggtccg ccgacattgt caaaatacac atcgacaccg tcaggacaag 720361 cgttttgaag cgctttttgg atatcatccg ctgttttgta attgatggct tcgtcaaact 720421 gaagctcctg ttttaaatag tcgatttttt catcagagcc cgcgatgccg acgactcgcg 720481 cgcctttgat tttggcaatt tgcccgactg ttgaaccgac ggctccggca gctcctgaga 720541 caaccacggt ttcgccttcc ttcgggcgtc cgatgtccag caatccgaag tatgctgtta 720601 agccggtcat tcccaaaatg ccgagatagg ccgaagcggg agcaaggctt gtatcaattt 720661 ttcgcaaggc agactcgctc acagcggaaa attcctgcca gctgagattt ccgatgacga 720721 tatcgccttt tttcagatga ttcccgtctg acacaacttc agcgataacc cctccagaaa 720781 gcgctttatc caaggcgaac ggctcaacat atgacttcgt atcctgcata cggccgcgca 720841 tataagggtc aaccgataca taaagcgttt tgacaagcac ttccccttgc ttgggttcag 720901 gaaccggaat ggtttcaaag cgaaagtctt catgaacagg aataccttgt ggacgtcttg 720961 ctaattgaat ttgctgctga gatgctgtca ttttcatcct cctatcactt ggttgacacc 721021 actgtaacat ggacaggaga ggaaatacaa aaggtaagct ggcatacaaa aaaggttata 721081 gatgagctta tgctttctac aagctctttt gttttaaaag ttctctttag tcatttatca 721141 ttattagaaa acagaacaga aaaagagctc ctgtacacct agctaagatt ggctagtgtg 721201 tatgtcgatt ctttttcata ttcttgcaag catctgcgag ggggagctta gtcgttcaca 721261 ttttgctttc gcatcaatct gcaatagcaa agtctatgcg atttttttac atcagcaaag 721321 atttgttcaa ttttttcctt ttatgccgag tttttctgaa acagataatt gatggtactc 721381 aaccattttc ttttggtcaa taaagtaatg tttacttatt aattaaacac gcgaaaaagc 721441 aaacgaaaac ataattaaat tttatatatt tattaaaagc ttatatgttt atttaccttt 721501 tttttgaatt gtaattgaga aaatccatat attgcggaca ctaataaaag aatacctgct 721561 gaaacataaa ctaaacgaac tccaaggaaa tctgaaatag cccctatagc cagaattgaa 721621 aacataaaaa tgaactgtac taaagaagac cttgcagaca ttatattaat tcgagtttgc 721681 tcggttgtta tgttctgaat aagtgtttct tgtgtaagat ctcttaatat ataagccggc 721741 cccataaaga gaaccaaaat tagagctaag tatgaattac ttataaaacc atatattaaa 721801 gttaaacttc catatgagac agcgccaatt aacataaaat taattaactt attttgaaat 721861 ctctccgaca gcttatatat tataaatccc cctatcatcg aacctaaata atatgctcca 721921 ttaataaatc cccaccatga ttctccttta tgcaagactt cgttaacgaa agctaaagag 721981 acagatccta tccaaatcat tcctgcccat gactcaatta aatccataat aataattgtt 722041 ctaagtttct tttggctaaa taaataccgc caaccactta ctatactctt attgggagaa 722101 tttttttcac gtatgacaga attagcgtgg ccatgtggta gacaaaataa aagagaaaga 722161 agagatgtaa acaacaaaaa gatagtaagt ataatggtat atccctcacc taaaaatgca 722221 attatgagac cacctaaaga ccagcctaca aattgaaaag tttggtccac tgtagataat 722281 aatccatttg cttttactct tctatcagga gagattattt cccctataat tgcacttttt 722341 aaaggtgaga accatccatt aaaaaaggaa atacagctaa taataataaa gactaaaatg 722401 agagtttgat tagagtaagt tcttaataaa gcatagaaca aacatattaa taacagcatt 722461 tgtatcaatt gagaaataat tattgtaaga ggcagtttta atcgaattgt tattaacggt 722521 aatatagcac ttccaaaaat acgaaaaata atacttatta atgtcaccat agaggcgatg 722581 gttgtcgaat tggtcatttt aaacaaaaac gaaatcacta ccatagtata tagagaaaaa 722641 cctaaatttg tagtggtctg gctaaataaa atagaataat aacctttact catatgtatc 722701 ctcccttgga ataatttttc tcggtaaaga gcttaaacat atttaaacac cttaaaacaa 722761 caaaagtaaa gaaaaaattt ccttgtaaac tatttacttt tattctattt attgttattg 722821 tttatttaag ttctctgact attctatcaa tattcaggga accacatatc ttattaaagg 722881 ggggaaaacc atgagaaaat taagaaaaaa ctggagaaaa tcgattgtta gcccggttct 722941 ttatactaat gaaaaatggt aaacacttag ggaatagcat ttaatgctat tccttatttc 723001 aacaaacaaa tcgggaggtt atcgtaattt gactctatta atgcaagatc ataaatcaat 723061 ttacaataaa gatatagaaa tattaattga agttgaagaa cttattactt ctgttccaga 723121 aaataaaaaa aatgatttta agagtttaat cgataataga attatgactc tactaaataa 723181 aattcaacac cctgtagcag cggaaaatgt gtttgggatg tgtattgctt atccgaatac 723241 ttacataagg tatagattaa ttgatttcgt tgaaaaatgg gtaccttatt tctctgctgt 723301 agaaactata atcaatctaa cccaggatcc ggatgattta gtttctttta aagctatgga 723361 tgtctgtgca aatcataaaa ttgaagaatc tgtagcatat ttgtcttcga ttattgatga 723421 tgtccgggag agtataagct accctaaaaa acctgtggga ttaggggccc aaaaagtatt 723481 aagtacatta ttagatatat tcggtgttga aaaacatgaa gagctagtaa tgctaaaaaa 723541 ttattttgat caaaatggta tacttcctaa taactttgac tttgaagaaa aaattcctca 723601 aagtctaata gaggaattcg aaaaaacaga agaagatggg atgattttaa ttccgggtgg 723661 cttttttgaa ttcggtttaa atgaaaatga aattcctgac aaaacattta attggaaaga 723721 tgctgttcct agacaaaaag tatggttacc tccatttttt atcgataagt atcctgttac 723781 aaataaagat tatgatatct ttaccgagtt catagaggaa aatgggcata tattctgtca 723841 tcctaatgaa ccgcagaata aacaacatag aagaaataca tattgggatg ataggtattt 723901 agataatcat cccgttacag gtatagattt ttatgatgca tttgcttacg caagatataa 723961 ggggaaagaa ttgccaaccg agtttcaatg ggaaaaagct gctcgaggcg aaaagggtaa 724021 tgtctggcct tggggagata aatttgatcc tgcaaaggtt caatatgctg gaagtcttta 724081 taatgaaccc attacttctt taaagtcctg gagagaaaat ttattaaaag ctcatgctga 724141 taaagaatta aatcatttaa caagtgatat ttttgaacaa aatggtgaaa gtccctatgg 724201 agtatgcggt atgatcggcg gaacatggga gtggactaga agtgagctta aaacaaagag 724261 agctttccac cctatttttg agaatgtacc atttaatagt gttaactcat ttgccgttct 724321 taaaggagga tcattcttct ctcatccagg cttaatgttc ccttctttta gagcaaaaga 724381 tattcctttc tgtcgacaca atgaaatggg gattagatgc gtaaagaata ttccagtata 724441 taaaattaga gaatcaatta atgggccaat tactaataaa gcaatttatt aatcattcta 724501 ggttagagac ttgataaaag tatactaaca ttgtgtagta atgttcagct tgtagaaaaa 724561 acaatgtttt ttctacaaga ttttatttta aatgcttttc aaaattatca gggattgaga 724621 atcagaaaaa gagccattaa gctcgatctt agctaggtat tacgatcttc tgtatattat 724681 tgtgagaaat atagaagatt cagttagtta gcatttcgat tttaagctga gcctgcaata 724741 gcaaagcatc tgttttgatt attctttttc tgatacataa gctaattttg tcgcttttct 724801 tttttgtctt ttcacgcatt tcgaggatga cttactataa ttctttcagc ttttctatgt 724861 gttaagattc gaatagatga aataacttta acaagttggt caataagaac agatttaact 724921 ttatgttaaa agagtatctc gtatagaaca taagaagaat gacgagtttt ttaagattat 724981 catcaattat gtgagaataa aatattataa gggaaaatga aggctgtcac gtttctcgac 725041 agccctaggg aattcctctc cttttcattt cgcccgtaat ttcgggcaca gtcccgtcgg 725101 caggcacatt ggcttctggt cgatcgggct tctcatgatg cagcattcca agccgaagac 725161 ttcacggaaa aatggctggg tgaacacatc ttccggtgtt ccggcgttgt atatttttcc 725221 gtccagcaca ctgatcagat agtcagcata ttgagcggct tggtttaaat catggagcac 725281 catgacaacg gtgcggccat ggtcgcggtt cagctttttc agcagttcaa gcacttcaat 725341 ctgatgtgag atgtctaaat acgtggtcgg ctcatcaagc aaaagcaaat cagtgccttg 725401 cgcaagtgcc atggaaatcc aggctctttg tctttggccg cctgagaggg catcaagtgt 725461 ccgatccttc agttcaatca tgcccgttgc ttccagcgcc cactctacca tgtcatgatc 725521 ctcttgggta tgcttggata acagcttttt gtgaggatgt ctgccaaaat agcataattc 725581 ctctaccgtc aatccttcag gagcctgagg agattgtgga agaatggcca gtttttttgc 725641 gacttctttt gatggctggc ggtggatgtc ttttccttct agtagcactg taccgctttt 725701 tggggccatc agcctggcga gcgatttgag gattgttgat ttaccgcagc cattagcgcc 725761 gatgagcgca gtgatttttc cttcttctat ctttaagtcg actccgtcaa taatcactgt 725821 actgtcatat gaaagagtga gctggtctgc agccagtttt cccatggtat cctctcccta 725881 ctgtttcctc gcttcgaatt tcaataaata taagaaataa ggcgcgccga tcacggctgt 725941 cagtattccg gcaggtattt caaccggagg catgatgccg cgccctaacg tatctgcaat 726001 taataatata atagcaccaa tcaatgccga tgcaggcagt aaatatttag ctttttctcc 726061 ggtaagccgt ctggcgatat gcggagcaag caagccgata aaaccgattg agccgacgac 726121 ggctacacag cttcccgcca gcgccaccgc ggtgaaaatc aggatgaatc tcagccggtt 726181 tgcgttttct ccgagaccct gtgcaagctc atccccgagt gacataagat ccagcttcgg 726241 tatgagtatg cagacgatcg gaaaaagaat caaaagccat ggcgcaagca gcttgacttc 726301 ttcccagttt cttccccaga ggcttcctgt cagccaaatg agtgcagcat tcacgtcgcc 726361 tggaaacttg accatcatat attgcattcc ggcgtggcag accgcgccta aagcaatgcc 726421 tgataaagcc agtgaagagg gctgaatgct cttttttcgg gctatcatta ataatagtac 726481 agcaataatg gcggctccgg caaatgcgga gaacggaagc acgtataccg gcgactcagg 726541 aaagatgaga atcacagcca tcgccgcaag tccggagcct tttgaaatgc cgacaacgtc 726601 cggggaagcg agcggatttc ggatcacacc ctgtaaaatc gctccggcag cggcaagtcc 726661 agcacctgcc aaaatcgcta atataatgcg gggaaggcga tattgctgga tgataaattc 726721 aaaggaatga tccagtccca gcagattcgt cactaccgca tcaggtgaaa tgtataatgc 726781 accgattcca atgctgatga cggacagaac gattaaaatc acggccaata tgagtatcgc 726841 cagtaagggg cgtttttgtt ttctggttgt tttcttcatt tcaggtttcg ccctttcctt 726901 gccaaatata agaaaaacgg cgttccgata atcgcggtga caatgccgac cggtgattca 726961 taaggaaatg caatccatct ggccagaaca tctgcgtaca ccagcaaaat ggcaccgaac 727021 agtgccgaaa acggaagcac gtattgataa tgttctccga tcagcttgcg gacaatatgc 727081 gggacgagca gcccgacaaa gccaatcggc ccggcgacgg ctacggaagc gccggaaaga 727141 attaaaataa tcaaactgat cagaatcctg atgccgttca tattttgtcc aagccctttt 727201 gctgtttcgt ctccgagacc gagaacagaa acagaaccgg aaaatacgag ggcaagcccg 727261 atgccaatga cagaaaaagg agcgatggtt atgacgtcct gccagttgct gccgtcgatt 727321 gcgcctgtca tccagtacag aacatcctca cctgactcat ttaaaataat gatggcctgt 727381 gtcatagagg agaggaacaa gtgcacggcc attcctgaca gcgccagctt gacaggcgtc 727441 attccgccgg atgaggcaat catatacaca atcgcgccgc ctgctgccgc acccgcaaaa 727501 gcgaatataa cagatgaata gggcgatgcc ggcagaatga cgagagaagc aacaacaaaa 727561 agcgatgcac ccgcattcac accgaaaatt tggggtgaag ccagaggatt tctggtcata 727621 gcctgcatca gcgcccctgc tacagctagg ctggcgccga caaaaacgcc gattaatgtg 727681 cggggaaggc gaagagtaga gatgatgagc tgttcctttg aaccgtccca tacaaaaaga 727741 tatttcaatg aatctatgat gctgatgtct gaggctccta ctgaaagatt cagcccaagc 727801 ccaaatataa aaataatcag tgcaatgata aacatcatca gtcttgatga tgagcgccgt 727861 ttggctgaat gatacaacag tctcacttcc ttactgcgtc tggttgcaaa aacgaagaag 727921 caaggattcc cctcgcttct catttgtcct atttattata cactttttta agcacatctt 727981 tggcgcttgt ttcactagac ttgatgcctc tgaatcttgt ccaagtgtca cggtccgcat 728041 catagacttg tccatttttc accgctttga gatttttcca gagcgggttc gttttccact 728101 catctacaat ggttttgcct tcgttggctg agatgaacaa aatatcagga tcgattttgc 728161 tcaattgctc aaggctgacc tcttgatagg cgttatctga cttcacagcg tgtgtaaagc 728221 ctagcatttt aaagatttct ccgtcatagg atgatgatgt atgaagctgg aaggaatccg 728281 ctcttgcaac gccgagaacg atgttgcggt tttcatcttt cggaagttcg gcttttagat 728341 cgttgatgac ttttttgtgc tcggcaagct tttcttttcc ttcatcttct ttatttaatg 728401 ctttagcaat ggtcgtaaag ctgtcgatcg tttcgtcata tgtcgcttca cggcttttta 728461 attcaatcgt cggggcgatt tttttcagct gtttataaat gtttttatgg cgctcagcgt 728521 cagcgatgat taaatcaggc ttcaaggaac tgatgacctc aagattgggt tcgctgcgtg 728581 tgcctacaga tgtgtaatca atggagctgc cgacaagctt tttaatcata tcttttttgt 728641 tgtcatctgc gatgcccacc ggcgtaatgc cgagattgtg aacggcatcc aagaatgaaa 728701 gctcaagcac aaccacccgc ttaggtgtgc cgcttactgt cgtttttcct tcttcgtcat 728761 ggatcactct ggaatcctta gactcgcttt tgccgcttcc gttgttattc tggcttgatg 728821 aacagccgga tacaatgagg caggcgagca ataaaacact catgatggca atcaacttgt 728881 tagaataggt gcgcatgtca ttcttccttt tttcagattt agtaatgaga atcattatca 728941 catgtaacac tataatagca tggcttatca tgtcaatatt tttttagtaa agaaagctgc 729001 gtttttactg ctttctcatg aaagcatcat cagacacaaa taagtggtat gcagcgttac 729061 cgtgtcttcg agacaaaaac gcatgggcgt tggctttaga ggtttcgaac atatcagcag 729121 tgacataagg aaggagagtg ctgagataac cggacaattt cttttctatt tcatctgtta 729181 gtgcaaattc aatgtcgccg atattcatga taatcgagaa aacaaagtcg atatcgatat 729241 gaaaatgttc ctcggcaaaa accgcaagct cgtgaattcc tggtgaacat ccggcacgct 729301 tatggaaaat ctgtttgact aaatcactca caatccaagc attgtattgc tgttctggtg 729361 aaaagtattg cattagacat acctcctgct cgtacggata aaggcagcgt ttcatggtcg 729421 tgtgctccgt gcagcggctt ctccttaatt ttgatttttc tgaaaatagg tcccgttcct 729481 atcactttac catggacgga aaacaaatag ctactaccat tcctcctgtt tttctcttca 729541 atgttctgga atctgtttca ggtacagacg atcgggtatg aaagaaatat agaaaacatg 729601 aaggaggaat atcgacatga aaccagttgt aaaagagtat acaaatgacg aacagctcat 729661 gaaagatgta gaggaattgc agaaaatggg tgttgcgaaa gaggatgtat acgtcttagc 729721 tcacgacgat gacagaacgg aacgcctggc tgacaacacg aacgccaaca cgatcggagc 729781 caaagaaaca ggtttcaagc acgcggtggg aaatatcttc aataaaaaag gagacgagct 729841 ccgcaataaa attcacgaaa tcggtttttc tgaagatgaa gccgctcaat ttgaaaaacg 729901 cttagatgaa ggaaaagtgc ttctctttgt gacagataac gaaaaagtga aagcttgggc 729961 ataaagcaag gaaaaaacca aaaggccaat gtcggccttt tggttttttt gcggtctttg 730021 cggtgggatt ttgcagaatg ccgcaatagg atagcggaac attttcggtt ctgaatgtcc 730081 ctcaatttgc tattatattt ttgtgataaa ttggaataaa atctcacaaa atagaaaatg 730141 ggggtacata gtggatgaaa aaagtgatgt tagctacggc tttgttttta ggattgactc 730201 cagctggcgc gaacgcagct gatttaggcc accagacgtt gggatccaat gatggctggg 730261 gcgcgtactc gaccggcacg acaggcggat caaaagcatc ctcctcaaat gtgtataccg 730321 tcagcaacag aaaccagctt gtctcggcat tagggaagga aacgaacaca acgccaaaaa 730381 tcatttatat caagggaacg attgacatga acgtggatga caatctgaag ccgcttggcc 730441 taaatgacta taaagatccg gagtatgatt tggacaaata tttgaaagcc tatgatccta 730501 gcacatgggg caaaaaagag ccgtcgggaa cacaagaaga agcgagagca cgctctcaga 730561 aaaaccaaaa agcacgggtc atggtggata tccctgcaaa cacgacgatc gtcggttcag 730621 ggactaacgc taaagtcgtg ggaggaaact tccaaatcaa gagtgataac gtcattattc 730681 gcaacattga attccaggat gcctatgact attttccgca atgggatccg actgacggaa 730741 gctcagggaa ctggaactca caatacgaca acatcacgat aaacggcggc acacacatct 730801 ggattgatca ctgtacattt aatgacggtt cgcgtccgga cagcacatca ccgaaatatt 730861 atggaagaaa atatcagcac catgacggcc aaacggatgc ttccaacggt gctaactata 730921 tcacgatgtc ctacaactat tatcacgatc atgataaaag ctccattttc ggatcaagtg 730981 acagcaaaac ctccgatgac ggcaaattaa aaattacgct gcatcataac cgctataaaa 731041 atattgtcca gcgcgcgccg agagtccgct tcgggcaagt gcacgtatac aacaactatt 731101 atgaaggaag cacaagctct tcaagttatc cttttagcta tgcatgggga atcggaaagt 731161 catctaaaat ctatgcccaa aacaatgtca ttgacgtacc gggactgtca gctgctaaaa 731221 cgatcagcgt attcagcggg ggaacggctt tatatgactc cggcacgttg ctgaacggca 731281 cacagatcaa cgcatcggct gcaaacgggc tgagctcttc tgtcggctgg acgccgtctc 731341 tgcatggatc gattgatgct tctgctaatg tgaaatcaaa tgttataaat caagcgggtg 731401 cgggtaaatt aaattaagaa agtgaaaaac acaaagggtg ctaacctttg tgttttttaa 731461 ttaattaaaa tgtttattaa cttagttaag gagtagaatg gaaaagggga tcggaaaaca 731521 agtatatagg aggagaccta tttatggctt cagaaaaaga cgcaggaaaa cagtcagcag 731581 taaagcttgt tccattgctt attactgtcg ctgtgggact aatcatctgg tttattcccg 731641 ctccgtccgg acttgaacct aaagcttggc atttgtttgc gatttttgtc gcaacaatta 731701 tcggctttat ctccaagccc ttgccaatgg gtgcaattgc aatttttgca ttggcggtta 731761 ctgcactaac tggaacacta tcaattgagg atacattaag cggattcggg aataagacca 731821 tttggcttat cgttatcgca ttctttattt cccggggatt tatcaaaacc ggtctcggtg 731881 cgagaatttc gtatgtattc gttcagaaat tcggaaaaaa aacccttgga ctttcttatt 731941 cactgctatt cagtgattta atactttcac ctgctattcc aagtaatacg gcgcgtgcag 732001 gaggcattat atttcctatt atcagatcat tatccgaaac attcggatca agcccggcaa 732061 atggaacaga gagaaaaatc ggtgcattct tattaaaaac cggttttcag gggaatctga 732121 tcacatctgc tatgttcctg acagcgatgg cggcgaaccc gctgattgcc aagctggccc 732181 atgatgtcgc aggggtggac ttaacatgga caagctgggc aattgccgcg attgtaccgg 732241 gacttgtaag cttaatcatc acgccgcttg tgatttacaa actgtatccg ccggaaatca 732301 aagaaacacc ggatgcggcg aaaatcgcaa cagaaaaact gaaagaaatg ggaccgttca 732361 aaaaatcgga gctttccatg gttatcgtgt ttcttttggt gcttgtgctg tggatttttg 732421 gcggcagctt caacatcgac gctaccacaa ccgcattgat cggtttggcc gttctcttat 732481 tatcacaagt tctgacttgg gatgatatca agaaagaaca gggcgcttgg gatacgctca 732541 cttggtttgc ggcgcttgtc atgctcgcca acttcttgaa tgaattaggc atggtgtctt 732601 ggttcagtaa tgccatgaaa tcatccgtat cagggttctc ttggattgtg gcattcatca 732661 ttttaattgt tgtgtattat tactctcact atttctttgc aagtgcgaca gcccacatca 732721 gtgcgatgta ttcagcattt ttggctgtcg tcgtggcagc gggcgcaccg ccgcttttag 732781 cagcgctgag cctcgcgttc atcagcaacc tgttcgggtc aacgactcac tacggttctg 732841 gagcggctcc ggtcttcttc ggagcaggct acatcccgca aggcaaatgg tggtccatcg 732901 gatttatcct gtcgattgtt catatcatcg tatggcttgt gatcggcgga ttatggtgga 732961 aagtactagg aatatggtag aaagaaaaag gcagacgcgg tctgcctttt tttattttca 733021 ctccttcgta agaaaatgga ttttgaaaaa tgagaaaatt ccctgtgaaa aatggtatga 733081 tctaggtaga aaggacggct ggtgctgtgg tgaaaaagcg gttccatttt tccctgcaaa 733141 caaaaataat ggggctgatt gcggctctgc tggtctttgt cattggtgtg ctgaccatta 733201 cgttagccgt tcagcataca cagggagaac ggagacaggc agagcagctg gcggttcaaa 733261 cggcgagaac catttcctat atgccgccgg ttaaagagct cattgagaga aaagacggac 733321 atgcggctca gacgcaagag gtcattgaac aaatgaaaga acagactggt gcgtttgcca 733381 tttatgtttt gaacgaaaaa ggagacattc gcagcgcctc tggaaaaagc ggattaaaga 733441 aactggagcg cagcagagaa attttgtttg gcggttcgca tgtttctgaa acaaaagcgg 733501 atggacgaag agtgatcaga gggagcgcgc cgattataaa agaacagaag ggatacagcc 733561 aagtgatcgg cagcgtgtct gttgattttc tgcaaacgga gacagagcaa agcatcaaaa 733621 agcatttgag aaatttgagt gtgattgctg tgcttgtact gctgctcgga tttattggcg 733681 ccgccgtgct ggcgaaaagc atcagaaagg atacgctcgg gcttgaaccg catgagatcg 733741 cggctctata tcgtgagagg aacgcaatgc ttttcgcgat tcgagaaggg attattgcca 733801 ccaatcgtga aggcgtcgtc accatgatga acgtatcggc ggccgagatg ctgaagctgc 733861 ccgagcctgt gatccatctt cctatagatg acgtcatgcc gggagcaggg ctgatgtctg 733921 tgcttgaaaa aggagaaatg ctgccgaacc aggaagtaag cgtcaacgat caagtgttta 733981 ttatcaatac gaaagtgatg aatcaaggcg ggcaggcgta tgggattgtc gtcagcttca 734041 gggagaaaac agagctgaag aagctgatcg acacattgac agaggttcgc aaatattcag 734101 aggatctcag ggcgcagact catgaatttt caaataagct ttatgcgatt ttagggctgc 734161 ttgagcttgg ggagtatgat gaagccattg atctgattaa agaggaatat gcgatacaaa 734221 atgaacagca tgatctttta ttccataaca tccattcgca gcaggtgcag gccattttgt 734281 tagggaaaat aagcaaggca tcggaaaaga aggtcaagct ggtgattgat gagaacagct 734341 cactcgcgcc tcttcctgcg catatcggct tgtcccatct tattacgatt attggcaatt 734401 taattgataa cgctttcgaa gctgtagcgg agcaaagcgt gaaggaagtt ttgtttttta 734461 tcacggatat gggccatgac attgtcattg aagtatcaga cacagggccc ggtgtgccgc 734521 cagagaaaat agaagctgtg tttgagagag gctattcttc aaaggggatg aggagaggct 734581 acggtctggc caatgtgaaa gactcagtgc gtgaactggg cggctggatc gaactggcga 734641 atcaaaaaac tggcggggcg gtattcactg tatttatacc gaaggagaaa caaaggggga 734701 atccatttga ttcacatcgc gattgcggag gatgattttc gagttgcgca aatccatgag 734761 agattgatta aacagcttga tggattcaag attatcggca aggcggctaa cgcaaaagag 734821 acattggcgc ttttgaagga acacaaggct gatttgcttc tgctggatat ttatatgccg 734881 gacgagcttg ggaccgcgtt gattcctgat atacgaagcc gatttcctga agtggacatt 734941 atgattatca cagcggcaac agaaacccgt catttgcagg aagcgctaag ggcgggaatt 735001 gcccactatt tgatcaaacc cgtaacagct gacaagttca ggcaggtgct gcttcagtat 735061 aaagaaaaaa ggaagctgct catgtctcag ccggaggtca gccaatccat gatcgaccat 735121 atttttggga acggtgtgaa gacagctttg ccggcagagg atttgccgac tggcattaat 735181 tcgattacac tgcgaaaaat taaggaagcg cttcagactg cgtcagaagg attgacagcg 735241 gaggaacttg gggaaaaaat gggggcgtca cgaacaactg cccgccgtta tgccgagtac 735301 cttgtgtcaa aggaagaagc aagagccgag cttgaatacg ggattatcgg caggccggag 735361 agaaaatatt atttggcggc ggattagata tgaaaaaatc tataatccta ttgaatattc 735421 tattgatctt tatgcagggt gatatcaggc aggcggctgc gccgcgcctg ccggacgggc 735481 cgatagaaat tgtcgtccct gccgaacctt ctggcggctg ggatgtcaca gcgcaggcga 735541 tccaatcagt tttgaggcag aagcagatcg tgaaggatga tgttcatatc gtctataaat 735601 ccggcggcgg gggagagaaa ggctggaaat atgtcaacaa aagcagcaaa caaaccatca 735661 gcatgacgtc cagcctaata ttgagcaatg atcttctcgg gcaaagcaaa ttaaaaatgt 735721 ccgattttac gccgctcgcc attctctcca aggaatggca gacggttgca ttgccaaaag 735781 gatcagcgtt aacaaatggc aaggatgtgc tgaatgagat caacatgcat cccggcaagg 735841 tgagaatcgg ctttgccccg gggtttggca atgatgatca gctctcgttc gtcagagcgg 735901 cagatatgta cggcattgac ccgtttgaca ttcaattctc acagtatgac agcagcgaac 735961 agctcattca ggcgctgatc agacatgaga tagaagcggc ttccatgaca ctttctgaag 736021 cgaaaccata tgaacgaaac ggcgatatca cgttagccgc tgtaacgtct gataaaagac 736081 ttcccggttt tccaaatgta ccgacgtgga aggagcaggg aatcccgttt gttttttctc 736141 attggagagg gattttgggc ccgaaaaata tgtctgagga agagatttct tactgggatc 736201 aagcgctaaa gaaggtcacc tcctcacctg aatggaagcg gaaaataaac gaacaggact 736261 gggaaagctt ttatttaaac agcagggaaa cgaaacggtt tttagaagag caatctgctt 736321 tttatcaaag catcatgaca ggaaattaaa atcccgacat cccgggattt ttttcatgcc 736381 gaaaattgat caaaaagaac aaaacggttt taaaaaatta aaaatacaaa aaaaccaaat 736441 tatttacttg cggttggttt tcccatacga tggcaaaaag gcaagacaaa aaggggagta 736501 agggagaaaa aaatgtaagc ggattcattt aagggggaat ggatgtgtta gcaatcttag 736561 gctttctcat gatgcttgtg tttatggcat tgatcatgac aaaacggctt tctgttttaa 736621 cagcattagt tttgacgccg attgtgtttg cgcttatcgc cggatttgga tttactgaag 736681 ttggggacat gatgatttcg gggattcagc aagtcgcgcc gactgcggtc atgattatgt 736741 ttgcgatctt atattttgga attatgattg atacaggcct gtttgatcca atggttggca 736801 aaattttaag catggtcaaa ggagaccctt taaaaattgt tgtcgggaca gcggttctta 736861 caatgctcgt cgccttggac ggagatggct cgacaacgta catgattacg acaagcgcca 736921 tgcttccgct ctatttgctg ctaggcatcc ggccaattat cttggcagga atcgcgggag 736981 tcggcatggg aatcatgaac acgattccat ggggaggtgc gacgccgagg gcggcgagtg 737041 cgctgggggt tgatccagct gagcttacag ggccgatgat tcctgtcatt gcaagcggga 737101 tgctttgtat ggtggcagtt gcgtatgtgc ttggaaaagc ggaacgaaag cgccttggtg 737161 tgattgaact gaaacagcca gccaatgcca atgaaccggc tgctgcggtt gaagatgagt 737221 ggaagcggcc gaagctttgg tggttcaatt tattgttaac gctttcttta ataggatgtt 737281 tagtatcggg taaagtcagt ttaaccgtac tgtttgtcat tgcgttttgt attgcgctga 737341 ttgtgaatta tcccaatctc gagcatcaga gacagcgcat cgcggcgcat tccagcaacg 737401 tgctggctat cggttcaatg atttttgctg cgggggtgtt cacggggatt ttgacaggca 737461 cgaaaatggt tgatgaaatg gcgatctcgc tcgtgtccat gataccggaa caaatgggcg 737521 gattgatccc ggcgattgtt gccttaacaa gcggcatttt cacatttttg atgccgaatg 737581 acgcgtattt ctacggggtg ctgccgattt tatcagaaac agctgtcgca tacggtgtgg 737641 ataaagtgga aattgccaga gcctctatta tcggccagcc gattcatatg ctgagtccgc 737701 ttgtgccatc cactcatttg cttgtcggac tcgtcggagt ttctattgat gaccatcaaa 737761 aattcgcatt gaaatgggcg gttctcgcag tgatcgtcat gacggctatc gctctattga 737821 tcggtgcgat ctctatttcc gtatgataat tcaggcgtaa tgacacacac taacggcata 737881 caacattccg gaggtgtcat tatgagtgat ccttatatgc cgctgacttc agtcagaagc 737941 ggagcggggt tcgaagcggc aaaaggggtg cacggcctga ctgtgcaaat tgcgaatgtc 738001 tattttattc agctgccttc tgaacctcac tcatttgttt taattgatgc cggcatgccc 738061 caatcagccg gcgtgattgt caatgaagcc aaacaaagat tcggtgaagg gtttcagctg 738121 aaggcgatta tcctcacaca cgggcacttt gaccatattg gggcaatcga agagatcctt 738181 gagcattggg atgtgcctgt ttatatccat tctcgggaaa tgccttatgt aacaggtaaa 738241 gaggattatc ctccggctcg tcctgacagc aagagcgggc tggtcgctaa gctgtcgccg 738301 ctgtttccgc ggcactctat cgatatttcc tcacatgtcc aggcactgcc ggaagacggt 738361 tcagttcctt ttcttgacga gtggatgtgg atcgcgacac caggacacac gccgggccat 738421 atttcgttat tccgcgatga cggccgcgtg cttgtggcag gtgatgctgt tattacagtg 738481 gaacaggaga aaatggctga cgtcttgata caaaaacagg agcttcacgg gccgccggct 738541 tatttcacgc ctgacacaga gacggccgct gagtccattc taaagctggc cggtcttgaa 738601 ccggaagcgt tattgaccgg gcacggcata ccgatgaccg gcaaaaactt tcgaagtgac 738661 ttaactgaat tggcaaatcg gttatcgtct atttgacacc cgcaccacgc gggtgttttt 738721 tattgttttc caggaagttg cagaaaaatc atttgtcttg ccgcttaaaa acgatacaat 738781 gaaaagcatg aagtgatgtg aaggggagag tttgttggaa gaaaaagaaa tactctggaa 738841 cgaagcgaaa gcgtttattg ccgcatgcta tcaggaattg ggaaaggagg aggaagtgaa 738901 agaccgtctc gcggacatta aaagtgaaat tgacctgacc ggaagctatg tacatacgaa 738961 ggaagagctg gagcacggag cgaaaatggc ttggagaaac agcaaccgct gcatcggcag 739021 attgttctgg aattcgctga atgttatcga cagacgagac gtccggacga aggaggaagt 739081 gcgtgatgcc ctctttcacc atattgaaac cgccaccaat aacgggaaaa tcagaccgac 739141 cattacgatt ttccctccgg aagagaaggg tgaaaagcaa gtcgagatct ggaatcatca 739201 gctgatccgg tacgctggat atgagtcaga cggagaaaga atcggcgacc cggcttcctg 739261 ttccctgaca gcagcctgcg aagagctcgg ctggcgcgga gagcgaacgg attttgacct 739321 gctgccgctc atttttcgca tgaaagggga cgagcagcct gtctggtatg agctgccgcg 739381 ttcacttgtg attgaggttc caatcacaca tccggacatc gaggcgtttt ctgatttgga 739441 gctgaagtgg tacggcgtgc ctattatttc tgatatgaag cttgaggtcg ggggcattca 739501 ttataatgcc gcgccattta acggctggta tatgggcacg gagatcggag cgagaaacct 739561 cgcagatgaa aagcggtacg acaagctcaa aaaagtagcg tccgtgatcg gcatcgccgc 739621 tgattacaat acggatttat ggaaggatca agcgctagtt gaattgaata aagctgtgct 739681 gcactcgtat aaaaagcagg gtgtcagcat cgttgaccat catacagcgg caagccagtt 739741 taaacggttt gaagaacagg aggaagaagc gggcagaaag ctgacggggg actggacgtg 739801 gctgattccg ccaatttcac ccgctgccac tcatatcttc caccgctcct atgataactc 739861 aatcgttaag ccgaactatt tttatcaaga taagccttat gagtaaacaa tagaaaatcg 739921 atgatggcct tcaaggctgc gggattcagt cacagagatg tcggtaacct ttgagaaagg 739981 gcttccgttc tttacagcct caacaaacga ttgcagggcg ttttccggac cctctgccaa 740041 aatctcgaca cgcccgtcat cacggttttt gacccagccg gccagttttc gcttatcagc 740101 ttccatttga acaaaatagc gaaagcccac accttgaacc cggccgtcta caatgattcg 740161 gtattgaagc atgtaaaaac caccttttct ttttatgata atcaatcatt ttacaacctg 740221 taaaggggat gtgtttgtat gaaacaagag cgctattcag ttctttctct taatctggga 740281 aaaccgcaga cgcttgaata tgacggaaag aaaatcgaaa ccggcatcat gaagcggccg 740341 gctaaatcag ccgtcatgct gtatcgggag aattttgaag gagacggaca ggcggacctc 740401 gtcaaccacg gcggacctga taaggctgtc tgtgtctacc cggcggagca ttatccgttt 740461 tgggaagagt tcctctcaag accgctgtca aatgccgcat ttggagaaaa tctgacggtc 740521 gcgggcctga ctgaggagaa tgtttgcatc ggggatgtgt tcagacttga tgaagctgtt 740581 gttcaggtca gccagccgcg ccagccgtgt gtaaagctgg cgaaaaagtt tggtgtaaaa 740641 gaaatggtgc tgaaggtcca gcaaaccggc tatacagggt tttattttcg cgtgctggag 740701 gagggcaggg tgtctcccgg cgcgaacctt gaattgctgt ccagaggaga gaaaggcata 740761 tccgtccagt tcgcgaaccg catcaactac catgatgcaa aaaatctcac cgccattgaa 740821 cggattttaa gtgaggctgc actatcggaa agctggagag cgtcctttat gaaaaaaaag 740881 gacaggctgc tgccggttga atagaaaaaa gccgcgcata tcaacgtgcg cggctttgcc 740941 atatttaaga ttgttttttc tttgattcaa gcaggttggc aagaaaatag gttttatagc 741001 tttgaagctt tcttccttca tggtgcgtga tcccctgctt ttttagttct gccacatacc 741061 agcctttact gccgtaatgc atgtcagaaa actcctttcc ctatctgatt tcgaaacgat 741121 tggcattgta acatctataa aaagatgctg aaaagagatg cggggaaaac tgagcctttc 741181 gcactagatg tacgaatgtt cttctgaatg tatatgcgga gcaaaagccg aatatgattt 741241 aatggccggt tagtttgatc atgacaacgc caaatgtcat aatggcgaaa acaatgccga 741301 tatatgtgag catcccgttt tttttcttaa cgccgtaaac ggtcataatg atgccttcaa 741361 tgaaaaaaat gatgccgaaa ataataaacc acatgcagat aaaggctcct ttcacagaca 741421 taatagtagt gtagcatatc tgaaagagcc gggctgtgac aatatcaaga aagccgggcg 741481 catatcgccc ggctcatgtt ttattgttta tcaaccaatt tgaccagaag ctgtgccaaa 741541 tgttctttct catcttcgtc tgcaacgctc caaagctctt gcagcagcat ttcttcaccg 741601 ttttgcggct cttcatgctt tgcgaggtag tctcccagga tcgcagcgct ttttacaagc 741661 ttgccgtcat ccaatcccag ctttttgcct cggttgactt gttttttcag gtagccttta 741721 aattcctcaa agtcttttaa aatgtcttct tttattgtgc catgcatcgc gttcatttcg 741781 ttttcaattt ggattttttc ttgatctctg ttcattgcaa gacctcctcg tacagaataa 741841 tgatgcttta cctgcaattg gaggaggtta aacctgccgg aagcccggaa tgtgttttac 741901 agtttcgtca ggataatcgg ttcatctttt gtgatgacga tcgtgtgttc aacttgggca 741961 accatgcttt tatccggcgt cttgaacgtc cagccgtctc cagcttcaac aatcgtttct 742021 gctttcgttg aaataaacgg ttcaagcgcg atgactgtgc catttttgaa cagcgcatta 742081 tcaaacggat cataatagtt catgatgtgg ttcggcgctt catgcaggct tcggccgatt 742141 ccgtggccgg tcagggtttt gatgacggta aagccttgag agcgtgcttc atgataaacg 742201 gctcttccga tctggttttg gcgcttgccc gcttttgcct gctgaagccc cttttgaaaa 742261 gcgttttccg cgcattggca aagcttatga aggcgttctt ctccttcacc gagcacaaat 742321 gagatgcctg tgtcggaata gaagccgcca aattcagcgg agatgtcgat gttgacaagg 742381 tcccctgctt ttaaaatttt ggatgtgctt ggtatgccgt gagccacttc atcatttacg 742441 ctgatacatg tcacacctgg aaaatcgtat tccttctcag gagctgaaac ggcgccgtgc 742501 tcatcaagca cagcttttcc gataaggtca aggtcttttg tgctcatgcc gggctctgcc 742561 ttccgcttca tttcttcacg cgcaagcgcg acgattcttc cgattttttt caggccttct 742621 aattcttgat cgtttgttac aatcatctgt cattcccgct ttctttttaa ataatctaga 742681 ttaagcttac cacaactgtc ttaaaaatag gaaacacacg gacctgggaa aaaagaaata 742741 cccccgggaa aattggtata gatcactaga tatcttatat ggtatatttg aaaaaaaagg 742801 gtatgagggg gatgggtatg ctttcatttt tacaaaaact cgggaagtca tttatgctcc 742861 cgattgcggt tctgcctgcg gttggaatta tccttgcgct tggcagagag gatgtattta 742921 atatcccgtt tgtctatcag gcggggacgg cggtttttga tcatctgccg cttatttttg 742981 cgatcggtat tgccatcggc atttcaaaag acagcaatgg ggcagcgggt ttatcagggg 743041 cgatatcgta tctgatgctt gacgcggcaa caaagacaat tgataaaaca aataacatgg 743101 cggtgtttgg gggaattatt gccggtttaa ttgccggtta cacctataac cgcttcaagg 743161 ataccaagct gcctgaatat ctcgggttct tcagtggcag acggcttgtg ccgattttaa 743221 cagccattat tacgatcatt ttagcgggca tattcggagt ggtctggccg ccgattcaat 743281 cgtgtatcaa ctcgtttgga gagtggatgc tcgggctcgg cggcatcggg gcaggcatat 743341 tcggcctatt caacaggctg ttaattccgc ttggccttca ccatgtgctg aacaatattt 743401 tctggttcca attcggagaa tataacggag tgacagggga tttggcgcgc tttttcgcga 743461 aagatccgac tgcgggcaca tatatgaccg gatttttccc aatcatgatg ttcggtcttc 743521 cggcggcgtg tctggctatg gttgtgactg cgaagccgtc taaacggaaa gcgacggctg 743581 gaatgatgat tggatttgct ttaacggcgt ttatcacagg gattacggag ccgattgagt 743641 ttgcatttat gtttttatct ccgcttttat acgctgttca cgcggtctta accgggttat 743701 ctttatttat cgtcaactgg ctcggcatcc gctcaggctt ctctttttca gccggagcta 743761 tcgattatgt gctcagctat ggaatcgcgg aaaaaccgct gcttctgctt ttggtaggta 743821 tatgctatgc ggcagtatac tttatcgtgt tttatgtact gattaaggct ttgaatttaa 743881 aaacgcctgg acgggaagac gatgatgtgg atgaagtgct ggatgaaaat actgttcagg 743941 atgtaaatga aaacatcatg ctgaaagggc tcggcggaaa agaaaacctt caaaccattg 744001 atcattgcgc cacaaggctg cgactgactg tgaaggatac cgctttggtg gatgaagcac 744061 tgctaaagaa agcaggcgca aaaggggttg tcaaatcggg cgggcaatcg gttcaagtca 744121 ttattggccc gaatgtggaa tttgcagctg aggaattgag ggctgctgtc aaataaaaaa 744181 gcggagaggg caacctctcc gctttttctt atttatcttc gttatccttt gacgtttcgg 744241 aagaatcttc gtcatgtttt gtgtaatcat aatcagaagg attcaccttc ttaaaacctt 744301 tcggctcgta gaaccgcagc aggtctccgt ttatgatttt atcggacatt tcaagttcct 744361 tcttgacgag tgagtcttct gacttgtcga cttcggattc atcgagttct tttccggttt 744421 tcgtgtcgta atacttaccg gatattttcg tgtacttcgg tgaaataaag tctccgtttc 744481 ggaacggaat cacttcacgg tgttctttcg ataaaatatc agaaccggac atcagatagt 744541 ccttcgtatc cactccgagc agatgcagaa tggtaggagc cacatcaacg tctccggcat 744601 atttatgaac tttctcgccc ttcacgccgg cagcgtggat aaagagcggc acccgttgaa 744661 gctgggcgtt gtcgtaatca gtgatttcat ccttgccaag cactttcgcc atcgctttat 744721 tgtggttttc agagatgccg tagtggtctc cgtacatcac aataatcgat ttatcatata 744781 acccgtcttt tttcagatca ttgaagaatt gttcaatgga ctgatcaagg taatgggctg 744841 actggaaata gttatcgacg acagagtcac caaagtctcc agccgggaag tctgtatccc 744901 cctcatccat tccgaatggg aagtggttgg aaagggtaat gaacttcgta tagaacggct 744961 gcggcaggct ttccagcagc ggcattgatt ctttgaagaa cggtttgtct ttcatgccgt 745021 agtttttcgt gttttcttcg ttcatgtcat agtaagcaga atcaaagaat ttatcaatgc 745081 cttccgcctt gtacatttcg ttacggttcc agaacgtctg cgtgttcccg tggaaagtag 745141 cagatgtgta attcttagac ttcagaatcg ccggaacgga ttgcagcgtg ttttgcgctt 745201 tgtttacgaa aactgaacct tgagccagcg ggtacagaga gttttccatc ataaattcag 745261 catcagatgt tttaccttgt cccgtttggt ggaaaaagtt atcaaagtag aacgtttcgt 745321 tatcatgtgc cagtttattt aagaatggtg tcacttcttt gccgtcaatt ttatagtcga 745381 tgataaatga ctgcaaagat tcaagtgaaa cgtaaatgac gttttttcct tccgctttgc 745441 cgaaatacac gttattcggc acatcgtaat tggctttcat gtagttttct acttccgtta 745501 cgtcgctgga atcggcaagc gcgcgctggc tgttggactt gatattctgt acagcgtcat 745561 aaatcgtgaa attgtatgtt cccaagtatt tcacaagata gttccggtcg aatgatcttg 745621 tcagcaattc aggacggtct gattccgcaa ctgccaggtt gatcaagaac acaagaattg 745681 aagacgcaaa aataattcgg aacgattttt tgcttgacgt ttcggcaggc ttgtttactt 745741 tgatcgccaa gatgatcagg atgatcgtat cgataaagta aaaggcgtca gtcggtctca 745801 tcagcgaaaa tgcgctgtca ccgagttggc cgccgtttgt tttagcctgc ataatgaccg 745861 gaattgtaat aaaatcattg aaaaatctgt agtacacaat gttggcgtac agtaaaaaag 745921 acattaaaaa atgaatcact ataatggctg tctgctgtaa ttttttcttg aacaagagtc 745981 caaagccaag aaagaacaag cttgagctaa gaggattcac aaaaagcaat attttttgta 746041 tcgtgttgtc tattcctaag ttgaaattca ggacataacc gacatacgtt ttgatccata 746101 acaggacgac cgcaattaag aagaaggcca gtcctctttc ttttataaat gttttcattg 746161 ttacactcct tttttccgat ccagttcgag cgaaacgata gaaaaaacga acgtatccaa 746221 tataacacga atcagcagat tagaaaagtg aaaatcgtat gagggagaaa gtggcgaaaa 746281 acgccgtcga atcaacgttt cgctttgata ttaccaaatg taaaacaagg tatctttcta 746341 gaaataaagg aataaaatgg tacattgaga attgtatgat aaaatataag gtatagataa 746401 aaagaggtga aatgatggat ttttcccata ttgtgtctga agataaaatt aagcgcgcca 746461 tcaaagacgg ggactttcaa aacctcccgg gaatggggaa gccgctgccg aaggatgacg 746521 cggcacactt gccggaatcg ctgcgcatgg gctatcgtat tttgaaaaac gcgggaatgg 746581 cagaggacga gggcgcgctc aaaaaagagc ttatgaccat cgaccattta atcgaaaagt 746641 gctatgacga aaaagaacgc gagcaattaa tcagaaaaaa atctgaaaag caattgctgc 746701 ttgataagct tgtcgacaaa aaaggcatgt tttcaaagcc agcatccgct ttttataaga 746761 ataaagtata tgaccggctt ggacgaaaca gaccttcttc cagctgattt gtcttgtctg 746821 caggatggcg attgataaaa gccatccttt ttatgttcca agttctatgt caaaaggttt 746881 atgtttttcc atctatggga aatgattcat aaacgaaaaa agggtgatgg gatggaacga 746941 ctattagtat ggatagagca tatatctgat tggctgtggg gtccgccgct aatcatcctg 747001 ctgacgggga cgggcttgta tttcactatt ttgctgaaag gttttcaatt tcgctatcct 747061 ttatacattt tcaaacagac aatcggcagt gtaggaaaaa agccgaaggg agaaggcaca 747121 gtcacaccgc ttcaggcatt gacctcagcc ctcagttcaa cgatcggtgc agcgaacatt 747181 gtcggtgtgc ccgccgctat tatgtttggg ggaccaggag cggttttttg gatgtggctt 747241 attgccttat ttgccatggc gattaagttt tctgaaagtg ttcttgctgt tcattacaga 747301 gaaaaaaatg agcagggtga atacgtcggg ggaccgatgt attacataac aaaagggctg 747361 cgcatgaaat ggctcggcgt attcttctct gttgcgctga ttgtggagct gattcccagc 747421 attatggttc agggaaattc ggtttcagtc tcgcttgccg agacgttttc tttcaataaa 747481 atatacgcag gaatcggaat tgcatttttg attgggttag tggtgatagg aggggtaaag 747541 cggatcggaa aagtaacaga gtttgtcgtg cctcttatgg caggggcata cgcaggtgcc 747601 ggtctcctga ttgttctcat gaatctatca tcagtgccgg cgtttttctc tctcgttttt 747661 tcaaatgcgt ttacctcttc ttcagcagtt ggagggttcg caggtgctgc gttggcggaa 747721 accgttcgct ggggatttgc ccgcgggctg tattctaatg aagccgggat gggaacagcc 747781 ccgattgcac atgcggcagc aatgactgat catcctgtgc ggcaagggtt ttggtctgtg 747841 atcggcattg tcattgacac cttaatcatc tgtacgacta ccgcttttat cgtccttgca 747901 tccggtgtat ggacagggaa gaacgcctca aatgacccgg cagcactgac aacggccgca 747961 tttcagcact atttcggttc tggaggagga tacttcgttt cggtttccct ggtcttcttt 748021 gtcgtatcaa ccattatggt tgtcattttt tacggcgtaa agcaagctga atttctgttc 748081 gggcggctgg caggacatgt gattaaattc gtttatttag cggctattat cataggtgcc 748141 gcaggcggag caaaagccat ttggggcgta ttggacttag cattggtttt tattgttgtc 748201 ccgaatgtga ttgcgctctt gttattgagc agaaaggtaa aagcgctgta caccgaattc 748261 tttacatctg aacagtacta cctgaaagat ataagaaaaa cgaaacaaaa gcctgtttat 748321 ccaacaaaag aagctaaaaa ttcctagtgt tttgcttttg cgccgaacaa tgctttgctt 748381 tttatgatca aataaatgag taaaggcagc aaaagagaaa tcactacatt aatgattggt 748441 ttgattctgt taaagtcgat tagctgattt gtatttaaaa aaaaccaaaa gccgcatacg 748501 actgagaaca tgccggttgg tgtatacatg gctttcgggt cgatttttga gtgtaaaaac 748561 gaaaggccgt ataccacgat atatagggaa cctgctatct tcaccataat gaccggaatc 748621 caaaaagccg cgatgatcag gtctgagcga tccagaaaat ccgtaatgcg gatctgcctg 748681 atgaccatat aagcaggatc aaagaaagta gatgtcaggt tgggaccaaa gacagaaatt 748741 gaagaaaata acatcacggc cagcaataaa gcgcccagca gtatcgcgaa aatggtgtat 748801 tttagcggga cgctccggtt tgagaagaga agcggaagga taatcaattc ccccattgtc 748861 ccaaacgcgt aatagcctga ttgaaggtat gggattagac cttcaaaaac aggtgtcaag 748921 ttttgaagct caatttgtgt ggccagcgta aatggaagga acaagaccag gatgccgaat 748981 ggaaatagga atatctgcgc cattctggtc aatgtttctt ttccctctct ggcaatacag 749041 atcgccacaa agataataac accgccaaga acagccattg gtgttctcgg gagaaataaa 749101 atgttaatca aattgatgaa aaaacgtata tcatgagcat tgattaacag gaaatacaaa 749161 gaaaacagta aaatgataat ccggcctgcg attggtgagg aatcgctcag cagctcatag 749221 atatttttat cctgatgctt tttcatcagc ctatgcatga gccagagtgc cggaatcacg 749281 atgacaacgc cgaggatgta gctgtgccag gcattttgtt ttgctgattc gatcatgaga 749341 atcggagcat gctttaatcc gactgctaac gtatacagag ctccgaaaaa taatccttgg 749401 tatgcagagg tcttgtccat aaagcacatc ctttctgtca tgttcaaaac ggaatatatt 749461 taaacaggtg ccccagccgc ggaagcaggg gattcactct catataaatc catagaaaag 749521 cacttcctgc aattagcagg ctgaaggccc attttgttag attgttagcg gaacgaaaat 749581 tcttccattc atatgcgtat atggcaatgc acacaatcaa tgtctgtacg atatagctga 749641 tcatgctgac gcacctccat taatggctga tcgttttgta taggacaccg ccctgctcaa 749701 tcgtcacaat tgggacgacg tgaacctcca tatccttata tacctcttcc cattcctttt 749761 tcagcagatt cttcgtggtt gccgtgcttc tgatggtcct gtcttgaaag ccggccgggt 749821 ccgcctttag cttttgcaaa cgatgaacgg tgctgatcac gtccttcttt atggttctgt 749881 ttaatgcttt ttgaatgatg taatactggt cattttctct cgtctcatag gttgattggt 749941 tttccataat aattcctttg gctctgatct cgattgtcat tgacagcttt ccgttttttt 750001 cagcggcatg aaaggatgca ttggactttt gaagctgaat ggatgcttgc cccatttgat 750061 tcggcaggtc tactatgaat tctggctggc gggcttgatt cagcaacatc agggctgctg 750121 tcatgtgttc atctttgaaa atatccatca atctgtcctt tttaaagatc gcaagcccgt 750181 caattttcaa attagatttg cctttccctc caggttttgt tttagatgca gagatgaccg 750241 gtgcatacgg atcactgcct atttctacta gatcagacat gaatctgctt aagaaaacgg 750301 ggcggctcgt tgcgataatg gccagctccc gaatcatttc cgccggaaac tgttcaagct 750361 gaacatcggt atttaaaatg tcccgcgctt ctccccggct gactaaaatg agcgccgtta 750421 atctgttctg cggatttcgc gttaaaatat caaagactgg ggcaacgccg tctctcgcca 750481 tatcctctcc aataatgact gtacgtctgt gggacgtatt gattgtccgt gacaaggagg 750541 tttgcagctt gttgttcgct tctctgatcg tagtgccgga agctgaatca acataccatg 750601 tttttgaacc ggcagttccg ccgccgcccc ctgtttgtcc gcctaattgg ccgaccaagg 750661 gaatctgcat ggccactcga tactgatctt ttttcttatc aatggctgag ctgacaacaa 750721 atgcaatgtc attgatttct gtccggtccc agcaccccgt tagaaggata caaatgagaa 750781 gcggcaaaac acacttatat attgttttct tcatcttttg ggtcctctct tttcgctccc 750841 ttctgtccgt tgccgcgcga atacgtgccc ggccttctgg tcatcgtcca ccaaggcgcc 750901 ctgacaaaaa tatcttttac ttcatctcgt ttaaacggag aaatcccgga taaataagga 750961 atgccgaaag attgcagctt gcataaatga agcactaaga taatcgtgcc gagcataatg 751021 ccgaatatcc caaaaatact cgccaaaaac ataagcggga aacgaagcat cctgatggag 751081 atagctaagt taaaccgcgg aattgtaaat gacgcgatcc ctgttaacga tacgatgatc 751141 accatggggg cagacacaat tcccgcttca acagcggctg tcccaatgac tagggccccg 751201 agaatactga cggtctggcc gatggttttc ggcaggcgca ctcccgcctc acggagagcc 751261 tcaaaagaaa tttccataat caatgcttct atgatggcgg ggaaaggaat cggttcacgc 751321 gcagaggcca cactgaacat taagtttgtc ggcattaagt cctggtggta tgtaataacg 751381 gcaacataaa tagccggcaa atataaagca acgaataaaa acatatagcg aagccagcgg 751441 attaagttag acatcaaata acgctcatag taatcttcac tggcctgcat aagctgccaa 751501 aacgtaatcg ggcctgttaa gacaaagggc gtattatctg tgaaaatggc aaatcggcct 751561 tcgagaagct gggcggcgac ggtgtccggc ctttctgtgt attgcagctg ggggaatggc 751621 gagtacgtgt cgtcttcgat aaattcttca atatatccgc tttctaagac agcatcaatc 751681 tttatctttt tgattctttt ttttgctttg tcaataacct ttggatcggc aagcccgtca 751741 atataggcca agacaacatc ggttttggtt ttcgtgccga ttttaaaaga gatcatttta 751801 agctgaaacg ttttgacgcg aaagcgcaca agagcggtat tgaccctgag gctttcagtg 751861 aagccctctc ttgaccctct gatggtcgat tctgttatcg gctcttcaat gcttcttctt 751921 tgtccgcctt ttatatttaa gatcaggcct tttgagtgcc cgtcggcaaa taaaaccgcg 751981 ttcccctcaa tgatggatgc agccactttg ctcatactcg tttctaatgc aacacttgaa 752041 attgatagag tattttgcag cgcctcttca tgttcatcta tttgatccgt caaatgcatt 752101 aagaaagggc ggagggcgtg atcctgaata tgttcagatt ttacaattcc ttcgatataa 752161 acaataaatc cgcacagccc gtttccaaag tcaaattgtc taaatacgat gtctgagcag 752221 ccttctgtta ataaggtcag attttcgagg ttttccttca aattgggaga gatcggtctg 752281 tcctgattgt cttcaagctc tttgatgagc tgaagcgctt tgtcgcgttt attcatagag 752341 gctcaccctg ctttttaatg tcatattcaa taagtgcttg tgacttttag ggtaaccttg 752401 tctgtttcat atattccaga ctaggatgaa agcgctataa aaaagtgttg actacctgta 752461 tatacaggaa tacaatatga ttataagttg tatatacaag ttataaaaac ggatacggag 752521 gggttggcat gggggaactg aacaaatcgg cacgtcagat tgtcgaagca gtcggcggtg 752581 ctgaaaatat tgcagcggca actcattgtg ttacacgttt gcgttttgct ttaatagatg 752641 aaagcaaggt tgaccaagag atgcttgatc aaattgatgt ggtaaaggga tcattctcga 752701 caaacggaca gtttcaggtc gtaatcggcc agggaactgt caataaagta tatgctgaac 752761 tggttaagga aacggggatt ggcgagtcaa caaaggatga agtgaagaag gcctcagaaa 752821 aaaatatgaa tcctttgcag cgtgctgtga aaacgcttgc agatattttt attccaatat 752881 tgcctgcgat tgtcacggcg ggtcttttaa tggggatcaa taacatttta acggcggaag 752941 gcattttctt cagcacaaaa tcgattgtgc aggtttatcc gcagtgggcg gatcttgcta 753001 atatgattaa cctgattgca ggcacggcct ttacgttttt gcctgcgtta atcggatggt 753061 ctgccgtcaa gcggttcggc ggcaatccgc ttctcggcat tgtgctcggg gttatgctcg 753121 tgcatcctga tttgctgaat gcgtggggat atggcgcggc agaacaaagc ggagagatcc 753181 cggtatggaa tctattcggc ctagaggtgc agaaagtcgg ctatcagggc caggtgctcc 753241 caattttgct tgcttcttat atgctggcga agattgaggt atttttaaca aaacgcacac 753301 ctgagggcat acagctgctc gttgtcgcac caattacgct tctcttaaca ggatttgcct 753361 cttttatcat tatcggcccg attacatttg cgatcggtaa tgtactgact tcagggctta 753421 tctcggtgtt tggttctttt gccgcactgg gcggtctgtt atatggcggt ttctactcag 753481 cgctcgtgat taccggtatg catcacacgt ttcttgcagt cgacctgcag ctcatcggtt 753541 caaagctcgg cggcaccttt ttatggccga tgctggcgct ttctaatatc gcacaaggtt 753601 cggcggctct ggccatgatg tttatcgtga aggatgagaa acaaaaaggc ctctccctca 753661 catcagggat ttctgcttat cttggcatta cagagcctgc catctttggg gtgaatctgc 753721 gatacagatt cccgtttatc attgcaatgg tcagctctgg cctggccgga atgtatattt 753781 cttctcaagg tgtgctggca agctccgtcg gtgtcggcgg cgtgccgggg attttctcaa 753841 tcatgagcca gtactggggc gcgtttgcaa tcgggatggc tattgtattg atcgtgccgt 753901 ttgccggaac atacgcgtat gcgagattca aacataaata acaagtgggg agcgggacgt 753961 gttgaacgtt cccttttccc gttttcaatt taaatatggt ggtggaaaca gatgaaaaca 754021 gaacaaacgc catggtggaa aaaagctgtg gtttatcaaa tttatccgaa aagctttaac 754081 gatacgacag gaaatggtgt tggcgatctg aacggcatta ttgaaaagct ggattactta 754141 aaaacgctac aggtggatgt gctttggctg acgccgattt atgattctcc ccagcatgat 754201 aatgggtacg atattcgtga ttattactcg atttatcctg aatacggaac gatggaggat 754261 tttgagcggc tagtgtccga agcacataaa agagacctga aagtcgtcat ggatcttgtt 754321 gtcaatcata cgtcaacaga gcacaaatgg tttcgcgagg cgatctcttc aatagacagc 754381 ccgtaccgtg atttttatat atggaaaaaa ccgcaggaaa acggttctgt tccgacgaac 754441 tgggaatcga aattcggcgg ctcggcatgg gagcttgacg aagcatcggg ccaatactat 754501 ttgcatctgt ttgatgtgac gcaggctgat ttgaattggg aaaatgaaga ggtcagaaag 754561 catgtctatg acatgatgca tttttggttt gaaaagggaa tagacggctt taggcttgat 754621 gtcatcaacc tgatttctaa agatcagcgc tttccgaatg cggaggaagg cgacggccgc 754681 tctttttaca ctgacgggcc gcgggtgcac gaatttctgc atgaaatgaa cgaaaaggtg 754741 ttttcacatt acgacagcat gacggtcggt gagatgtctt caacaaccgt agaccactgc 754801 atccggtata cgaatcctga caataaagaa cttgatatga cattcagctt ccatcatctc 754861 aaggttgact atcctaacgg cgaaaaatgg gccttggcgc cgtttgattt tttgaagctg 754921 aaggagatcc tatctgactg gcaaacgggg atgcacgcag gagggggatg gaacgctctg 754981 ttctggtgca atcatgatca gccgcgcgtc gtatcaagat atggagatga tggcgcatat 755041 agggtgaaat cggcgaaaat gcttgctacg gccattcata tgatgcaggg cacgccttat 755101 atttatcagg gcgaggagct ggggatgacg aatccgaagt tcactgacat aagctcctat 755161 cgggatgtcg aatcgctgaa catgtatcac gcctttaagg aaaaaggaat ggctgatcaa 755221 gatattacag ccattttaca ggcgaaatcc cgtgacaatt ccagaacccc cgttcagtgg 755281 gatgctacgg aaaatggtgg ttttacaacg ggcacaccat ggataccggt tgcaggaaat 755341 taccgggaaa tcaatgctga agcggcgctg agggatcaga attcggtgtt ttaccattat 755401 caaaaattga ttcagattcg caaaatgtat gacattgtga cagagggtac gtatgagata 755461 attgcaaagg atgacccgaa catttttgcg tatctcagac acggcagcaa tgaaaagctg 755521 ctcgtgatca ataattttta cgggacagag gcggccttta cactgccgga ctctttagcg 755581 cctgacgaat ggaaggcaga ggtgctgttg acgaacgatg aagcaaggga agggcttcag 755641 aacatgacgc ttcgcccata tgagtccatt gtttatcgtt taacgaaacc gtgttaaact 755701 aagctgggtg gtccataatg aaggtgaata aattcatcac aatttataaa gacatcgcac 755761 agcaaattga aggcggccga tggaaagcgg aggagattct tccgtctgaa catgagttga 755821 ccgcacagta cggtacatca agagaaacgg tccgaaaggc gcttcatatg ctcgcgcaaa 755881 acggttatat ccagaaaatc aggggaaaag gctccgtcgt gctcaatcgt gaaaaaatgc 755941 agtttcccgt ttcgggcctt gtcagcttca aggagctcgc gcaaacgctt ggcaaagaaa 756001 cgaaaacaac tgtacacaaa ttcgggctgg agcctccgtc agagctgatc caaaaacagc 756061 tccgggccaa tctggatgac gacatctggg aagtcatcag gtctagaaag attgacgggg 756121 aacatgtgat tttggacaag gattactttt tcagaaagca tgtccctcac ctgacgaaag 756181 aaatttgtga aaactccata tatgaatata tagaaggaga gctcggtctt tcgatcagtt 756241 acgcccaaaa agaaattgta gccgagccgt gtacggacga ggacagagag ctgctcgatt 756301 tacgcggcta tgaccatatg gtcgtggtga gaaactacgt ctttttggag gataccagtt 756361 tgtttcaata tacggaaagc agacaccgtc tcgacaaatt ccgatttgtt gattttgcgc 756421 ggcgggggaa atgagagagg cgcctgcctg cggcagcgcg cttttttgtt tggtatcaaa 756481 attgatacta tccaacaaaa atgtgcgtac ttttactttt tatcataatg gctacaatag 756541 agatgagagt aatctaaagg agaggtgttt tacatggcag atctaaagac acaaattctg 756601 gatgcataca atttcaggca tgcgactaag gaatttgacc cgaataaaaa agtgtcagac 756661 agcgattttg aatttatttt agaaacagga agactgtctc cgagctcact cggccttgag 756721 ccttggaaat ttgtcgtcgt ccaaaatccg gaattccgcg agaagcttcg tgaatacaca 756781 tggggcgcgc aaaagcagct gccgaccgca agccatttcg tcctgattct tgcgcgtaca 756841 gcgaaggata tcaaatataa tgcggactac atcaaacgtc atttaaaaga agtaaaacaa 756901 atgcctcaag acgtgtacga aggctattta agcaaaacag aagaattcca gaaaaacgat 756961 ttgcatttgc ttgaaagtga cagaacattg tttgactggg catcaaaaca aacctatatc 757021 gcgcttggca acatgatgac tgccgctgcg caaatcggtg ttgattcctg cccgatcgaa 757081 ggcttccagt acgatcacat tcaccgtatt cttgaagaag aaggccttct ggaaaacgga 757141 agcttcgata tttctgtgat ggtggcattc ggctaccgag tgagagaccc tcgtccgaaa 757201 acaagatctg ctgttgaaga tgttgtgaag tgggtttaaa agaagaaagc tgctcgcata 757261 gcgagcagct cttttttatg cctgattcgc tctattctgt tttctcctct gatgtaagta 757321 cattgccgtt ccgagtgcgc tgatcagaaa tccggccaac aggatcgagt acatggatgt 757381 ggctgtgtcc ggaagcaggc cgccagccgg accgtctgtt cctgatccgc ccgaaccgtt 757441 tccaccagag ccgttagtcg gttgagtgcc gggaggcgta tcatttcctc cgtttccgtc 757501 agttggctgt tttccgcctg gtttgtcgga gcctccgcca tgattgccgt catcaccgcc 757561 tgtcggttga tctgacggga atgccggcgg tttgttgttt gaaccggaat ttaagatcgt 757621 gtattcgctg aagtggtttg tatatcctgt caccatatca tcatcgactg atccgtgacc 757681 tgtctttgtg aaagctttct tttttctatc gacgtgataa atggcagggt tatgggcttc 757741 ttcaatatca aacatgcgaa gcgaaagctg tacgggctcc ttgaatgatt ttatttcttt 757801 tcctttttgc ttcactgtaa agtcatatac atctgacagt gacacatcca attctcccgt 757861 agacttgatt ccgattgcag tgtctgcggt tttaaggttc gccattggca tcttcatgct 757921 gtaccagtag ttgaacatcg tcaatgaagg atctgactct ctttctttca aaagtttgac 757981 ctgatctttt ttcactttaa gattgatagg cttctcttga gatccttcat gtattccata 758041 atagacaaat ggcgtgttgg catttttagc ataaatcgca aatttgtctt catcaagtgt 758101 ccagctgccg tccttctgct ttgtcggcag gaatacttct ttgattcgtc cttcaacttt 758161 aggagagacc ttgtttccta gttttttcag ctgttcggtg aaaatctcat aatcaacgta 758221 gccaaggtct tcaccatggg aggcttctgt aaagacagaa tatccgtctc ctccggcacc 758281 gacaaaatta tttgttgcca cgcggtaggt atcatccgta tttatagcaa ctttgtctcc 758341 gttaggcgat tcaattttca cttctaacac acggtgtcca ggtttgttgt ttaatgtaaa 758401 ggtatattcg attccggcca cctgagggaa agcgccgccg ccattttcca cattgcttag 758461 gccttgttca agggcttctt taatttgttt tccggttaaa tcggccacgt aaagcgtatt 758521 gccgaacggc atcacgttga gcacctcgcc gagtgtgata tcacctttgt caatgcctgc 758581 tctgatgccg ccgccatttg ttatcgctat tctggcgccg gctgcttctt tcgcttttgc 758641 cagcataccg tccgcgatga agtttccgag attcgtttct ttcgtgcgca catgctcacg 758701 ctggccgtca agcgccacat ccgtgtagcc gactttttca tttttcacgt cctctaattc 758761 atttttgaac tgatcgagct cttgttttgc ttctgggttt tcttctgtat gttcatcaat 758821 tggcagcacg ctcagatttg atttatctgt ttgcacaacg cctttttcat caaacgcgac 758881 atcaacgcgc cccaagaatt ggccgtattc ttttgcctgc gccacgatcg tcggttcttc 758941 gttgttcacg acctccattt tgtctacgag ggtgtgagtg tgtccgccga tgatcaaatc 759001 aatgcctttt acttttttgg ctagctcaag atcccggtta tgtccgatgt gggttaaagc 759061 aataatttta tttacctttt cttcttcttg aatcgctttg acggtgtttt gtgctgtttc 759121 aaaggcatca ttgaatacga tgcttttgcc cgggcttgat gtggtggctg tatcttctgt 759181 tgtcaggccg aatacggcga ctttctcccc gtcaacgtct aacagaatgt aagggtgaat 759241 gccggcctct ttcttttcac ctgccgtaaa ggtttgcggc tttttgacaa atgatttcag 759301 cttgggctca tttgacacat ctacgtttgc actgacaatc ggaaattccg gcgcttcaaa 759361 gtgatagcgg ttcgccggat caacggttgc gctgtttccg cttagaaaat cagaaagcac 759421 cgtcgggcct ttgtcaaatt catggtttcc gaaggtcatg gcgtcatagc ccatcatgtt 759481 catcattttc agatcggcca aaccgttcca tttagtaaaa tacagatcgc cggaaaacac 759541 atctcccgca tcaaggagaa tattgtgatt tgtttcgctg cgtacttcgt tgattttcgt 759601 cattcgtctc gctgcatcat cgagatgggc gtgcgtatca ttggtgtgca tgacggtcag 759661 atcccacagt ccgtctttag gaggatctgg atttgaatca tcatcgaatt gcagcttata 759721 cacaccatag ccttcattcg cagacttgcc tacataagcg acatcgtctg ctttatcggc 759781 aaatggcttg gccaaaagcg aggattcaaa cgtcagattc gtgccggaaa caggcgcgat 759841 tgaccagttg ttgtctgctt ttggattgac tgttttttgt tcaataatgt aatccatcag 759901 cacctgccta ttttcaactg cagagccgtg gacaatttta tcgctcgtca gatgagggaa 759961 cccgccgcct ccggacgcac gatagttatt ggtgactacg agaaattcct ggcttgggct 760021 gatcggcttg ccttcatagg aaagattgat gatacgggat gaatccgcat tgatcacttt 760081 tccgttctca ttgtatttag ccggttttgt cacatcgacc tgatatgtga caccgtcaat 760141 cacgtcaaaa ttataggagc ggaaattctc gttcagcaag gcctggtcgc cgcctttagc 760201 tggatcaatt tgattgaatt ggcctgctga catctccagc cagtccttga cctcgctgcc 760261 tgtcagcttg acgatttgaa cagtattatc gtaaagatac aagtcaccga catttttaat 760321 cgcaagatct ccggctggaa tgtttgtata gtaattggct ccgtttctgc cgcctgcttt 760381 aaacggcgct ccagcggata aaatcggcag gttcttgtac tcggtatcct tcatttcttt 760441 ttcagcgtac cacttttgcg cgtcagtcac gatctgaatg gaaggatcat ctttgacctg 760501 tgcaaagaag ctgttaatat ctgcttcggt tttgccgact ggctttcgga catactccag 760561 tgtgttttgg tgtgtttgct gaatggtgtt tgtaacggtt tcgtttcttg atgtgacgtt 760621 gccagcaata gattcaatac ttcctttgga atctgctacc ttccatgagc cgtccgcctt 760681 ttcaagcttg aggtcaatca cgcctaaata tttgccccag ctgcttggca tgacgacagg 760741 aatgccgtta attgttccct tttccacatt gaactgagca acacccgcat actcggcgga 760801 aggaaagagt ccgtgctgat ggcccgagat aatcgcgtca atgcctttcg ttttggtggc 760861 aaggtcaaac acggcgtttt ctgcgcctga tgattgcgcc tgcttttcaa tgccggtgtg 760921 ggcgagggca ataatgacat ctgcgccttc cgccttcatt ttcgggatcg tttcattggc 760981 ggattctacg atatcctgca cctgaacttg cccctcgaga ttctttttgt cccatgtcat 761041 gatttgcggc gggacaaagc ctatgtagcc gacttttact ttctgctcat taccgttttc 761101 atcaatgagg gttttttcat taatcacata cggcgtataa cggttttcgc cgctagttgt 761161 tttgacgttg gcatttacaa tcgggaaatc ggctcctttg attgtgccgt cgagaaagtc 761221 gagcccgtag ttgaattcat gattgccaag cgttccggcg tcgtatttca gcgcattcat 761281 gacgctgata atcggatggg ttttcgtgcc ggagataatg tcgtcttttt gatatttcac 761341 cgcgtattca cccagcggat tcccttgaat caagtcgccg ttatccacaa gcagggtgtt 761401 agggttttgc tcgcggtgct tttggatcaa ttgcgctgtt ctcgccagac cgaaatccgc 761461 cgtttctttg tcgctgtagt aatcgtaatc catcatgttg gcatgaatat cagtcgtagc 761521 caaaatactc agatgcacct gaggagccgc gctttcttct gcatgaatgg gtggtgttgg 761581 gaggattagg ctaagtatca taattggggg caaaagaata cggagaatgt tttcgacgtg 761641 tgttcgtctt ttctgtattc tcaccagttc tccacctttc aacgaaattt gtgttacagc 761701 tcctattgta agaatatttt gtaactattt gtaggtgttt ctttatgatt attgtaaaag 761761 ggagaaaaat gagtattatg tagcagtatc aaacgacaaa tactgggcat ttatgcttat 761821 cgtttgtcac aatcgcggaa tgtttatttt agtgtggctg gggtagagtg ttttatgtag 761881 acatataaag cgggaggtta tgaatcatgg ggaaaaaaat tgcagttgtt ttaacatatt 761941 attttgagga cagcgagtac actgagcctg cgaaagcctt taaagaagcg ggacatgaac 762001 tgactgtcat cgaaaaagaa aaaggaaaaa cagtaaaagg caagcaggga acagcggaag 762061 tgacggttga cgcgtccatt gacgacgtaa attcttcaga ctttgatgcg cttttgattc 762121 ctggaggatt ttcaccagac cagcttcgcg ctgacgatcg tttcgtccaa tttacaaaag 762181 cgtttatgac tgacaaaaag ccggtatttg ccatttgcca cggcccgcag cttttaatca 762241 atgcgaaagc gctcgacggc cgaaaagcga cgggctatac gtccattcgt gttgacatgg 762301 aaaacgccgg tgccgacgtt gtggacaagg aagtggttgt ttgccaggat caattggtca 762361 ctagccgcac accggacgat ataccggcat ttaaccgcga gtcattggca ttgcttgaga 762421 aataagaaaa aacggacgct cttgggcgtc cgtttttttg ttgcttaggc ttgagcacct 762481 gtcagtttct tgtacctgta atacaagaaa gcagctgcag ccgttccgat gaccgcaatg 762541 ccgaagtcga atatgaaaat atgggcgatg ccccccgctt ttgcgataag ccctgttgca 762601 atcggcagca gaatcgatgc aagacttgaa gcagtcgcta caattccggt aacggttcct 762661 tttcgcttcc agaaaagctc tgtcattaac gtaatggtaa tttgaaacac acccgcagtt 762721 gaaaagccta agaaaaaggc agtgatgtcc agcacaactg ggatatgaac ggtcagcatg 762781 actgcgagcg tacataaagt aataatagga tataagagcg ttatgaagac aggtttgacc 762841 catctattca gcaaaacggc taataataaa acagatgcca gagatcctat actataatag 762901 ctcagcaatt gtacagatgc tgattcagct aaaccggctg ccttttgcgc gtagctcggg 762961 agccagattt gagaaaccgt aaataaagcc gtggatgtaa aaccgatgat aatcagtgcg 763021 gtgccttcct tctgaaaaac gggttcagac aagaaaacgg gagattcctg ttggccgcta 763081 ttagttggtt tcttatgttt tttaggaaac gaaagcgttg ataaataaat aatattcagg 763141 agatagaccg ctgccggcag ataaaaagca aatccgtaaa acatgctgtg gtctgctaaa 763201 aatgtgatca aaagcggcaa aagtgcggcc cccacagaca taaaggcttt aaccaagaca 763261 tttgccgaac cggaagcaga cggaaagagc tcggttaggg ccggatatgt tccggcatcc 763321 atggctgaat tagcgactcc ggctaataaa gcgaacacaa acgccagctc atagctcggt 763381 gataaaggaa taccgactaa aaagacggcc ataattcccg cagaagcgac aacaagcggc 763441 tttctgccga ttttatctga tagaacgccg gaaatgccgt atgtcagcag tttgccaaac 763501 ccgatagcgg caatgacata actgatgccg gtcggatcgg tattccactg ttttgttaat 763561 gaagacatat tggatgcgag aatgatgttg accatcccca gaaagaagta gttgatatac 763621 attccggatg ctgttttgat agatgtcgtt tgcatgcttg tactccttca aatcttattc 763681 gaacactttg ctgttttggt ttggggaaat gataaaaaag actcgccgag tttccggcca 763741 gtctccatta tttacgaagc gaggctaatt cttgagcaat cgcctgcatt tcacttgggc 763801 tgaatgattc ttttttcatc accattctgt gaaggtacgt gaggtcttca atcttctcat 763861 cactgaaatc ctccgctttg attacgccga cgttcagcat gttcagcttt tgggaaatct 763921 cttcaatcat ttgagttaat gtttctgtat ttgggctgga caaagggttc catcctttct 763981 atgcgcaata taggtatgtt ttattctaac agaattccat cagaaaaaaa ccctattcta 764041 aaagcaggct gttcattcca aaaaagtgaa gacatcagtt gaaaagaaaa tgaacatcct 764101 actaagatat tcatgaaggt ttctttttag agaaataggg gcaaagaata gggaggttgc 764161 acatcatgat aagcgtgtta tttgtttgtt taggtaacat ttgccggtct ccgatggcgg 764221 aagcgatttt tagggacctg gcagccaaaa aaggattaga ggggaaaatc aaggcggact 764281 cagccggtat tggcggctgg cacatcggca accccccgca tgagggaacg caggagatat 764341 tgcgcagaga aggaatcagc tttgatggca tgctggcgcg tcaagtcagc gaacaggatc 764401 tggacgattt tgattacatc attgcaatgg atgcagaaaa tatcggaagt ctcagaagca 764461 tggcgggttt taaaaacacc tcgcatatca aaaggctctt ggactatgtt gaagattcag 764521 atctggctga cgtacccgat ccttactaca cagggaactt tgaagaggtc tgccaattaa 764581 tcaaaacggg ctgtgagcag ttgcttgcat ccattcaaaa agaaaaacaa ttgtgagtga 764641 aaggagaatt tgcatgaaca acgaacgttt aatgctgaaa gggatatttc tcggagctgc 764701 ggcaggcgcg gcgttatcac tgctccataa gccgacaaga caggcgtgcg ggatgagatg 764761 gctgacatgc aagcataaac tttcactgta caaaagcaac ccagagctgt taaaaaacac 764821 tgtcatcaca aaagtggatg aggccaaaaa gctcgcccga acgctttcaa aggaagtcga 764881 ctttgtgaac cagcaggtga aagagctgaa gaaaacaacg ccgcaagtga tggaactcgt 764941 gcaagaaacg aaagagcatt tttcaaaaaa atgatcaaac atgcgaggtg agacgacatg 765001 agttttttga aagagctttt cagcagatac acccttcatg aaggacaaag taaatcagcg 765061 gagctggcgt atttttttct attgtcactg tttccgtttt tgatttttat gctgacgctc 765121 accgcgtatc ttccgctttc taccgatgat gttttaggag tcatagaaca atatgctccc 765181 gccagtgcga tgtcactcgt tgaatccatt acccatcaaa ccttaaataa tcgaaatggc 765241 ggtttgctgt cattcgggat tatcgccgca ttatggtctg cgtctaatgg aatgaatgcg 765301 atcgtccggt cgctgaacca cgcgtatgat gtggaagaaa accgctcttt tatcattgtt 765361 cgtctaacct cgattttttt gacgattgcc atggtattta cgattttagt ggctttgctt 765421 ctgccggtat ttggccggga gattggaagg ctcgcttctg actttgtcgg cgcgtcggat 765481 ctgtttttat ccgtctgggc cgccattcgc tggggtgtca gcccgcttgt gcttttgatt 765541 gttttttccg cgctgtatgt gattgcgccg aacaaaaagc tgtctctccg gtttgtcatg 765601 ccgggtgcgg tctttgcgac tatcggctgg atcattgtca gcacattgtt ttcattttac 765661 gtcagcacgt ttgcgaacta tagcgccact tacgggagca tcgggggaat catcgttctg 765721 atgatttggt tttacttgag cggcatttta attatcctag gcggagaaat caacgctctt 765781 ttacataaac gtaaaaagct tcctgatgaa aatccctacc attagcgcac cctataaacg 765841 aacttcggtt caaaaagaag tcggggggat atcgtgatga ccaagcatac gaaaaaaggc 765901 ggaagccata acaaacaaaa ctcgaaaagc aaatcgagcc ataaaacaag cggaagcgcc 765961 aacggacaaa acggctacca ttagcataaa agcctcctga catgatgtcg ggaggctttt 766021 tgattaagaa gatgaagaat aggtttcagc cggtgaccag cttttcggtt tgcccagcac 766081 aagggccagc cacacagagc taagcgtgag agtaatgaag tagaacaagt ttgcgctttc 766141 aaatgtctgc atataccagc cgccggcaac tgggccgagg atgctaccga gactgaatgt 766201 aatgccgcaa agcaggtttc ccgccggcag gaggtgaggc ggaagaaggt ctgtcatata 766261 gctgatgcca agtgtaaagg ttgatccgac tgccattcct gcaataaaaa agcagccgcc 766321 gatcacgtag ggcgaaggaa atacaccggc gatgaaaaag caaagagccc cagtcagtaa 766381 aatcaccagc agcacattcc gcctgccgta tttatcgctg aggatgccga gcggaaactg 766441 aaagataatg cttccaatcg caaatgcggg aaggatgatc gctactgcgt ctactgatat 766501 ccccaaacgg agcgcgtaca ccggaaagct tccgttcagc gccgtttcca gaaagccata 766561 gccaaatgta ggcataaagg caacccaccc aaacagcatg gcctgataaa atcgcctgaa 766621 actattgtct gatttggttt catgaggact ggtttccggg tatgcatttt gtagaaagaa 766681 aacaaaaagc cacgcaaaca gactgatgca gccggacacg ataaaaggaa gcgacggact 766741 cagcttgaca agcggcacca tgaacgggcc tgcggcaaag ccaaggccaa aggaaagccc 766801 ataaatagac aggtttcttc cgcgattttg ttttgatgac atggaggtca cccacgtttg 766861 cgtagaaaag tgaagcatgt ggtcgccgat tccaatgaac aggcgaagca ggaaccagac 766921 ccaaactgac tgaagccaaa taaatccgaa taagcttaaa atgacaatgc ttccgcccat 766981 gacgatcagc ggcttgaacc cgagctttct gagcggtgct tccataaacg gcgaagccaa 767041 aagcacaccg atatacagcc cggtcgcgtg caggccgttg atagcagcgg attctccatt 767101 tgtttcaaaa atgattgaaa tgacaggcag cagcatgcct tgtgaaaacc cggaaatgga 767161 aacgagcaag acaaggataa agaaatgaaa tcgtgacatc gtgtcagttc tccttatatg 767221 gaatctatgt tgatcgtaca acgttttcca aaagcaggca acctgaaaaa agcctatatc 767281 acgctataca tttgccctcg tgtaatcatg aaggtttttg tgaagaataa aaataaaaca 767341 agtcataaaa aaggagctat ttcaccatga atcgtatctt ttttatttta gtggcggccg 767401 gtgttccgct ttctgtgatt ggcagtttga tgcattggcc ttccgcggtt ctatttgcag 767461 tttattgcgt gacgattatc gcgcttgcaa gctatatggg gagggcgaca gaatcactgt 767521 ccatcattgc aggaccgcgt atcggcggtt tgttgaatgc aaccttcggg aatgcggtgg 767581 agctgattat ttcccttttt gcattaaaag aaggcctgac aggaatcgtg cttgcctctt 767641 taaccggttc agtgctgggg aacctgttgc tggtagcggg cctatcgttt tttgtcggcg 767701 gtttaaaata taagcggcag gaatttaata tccatgatgc ccgccataac tccgggcttc 767761 tgatttttgc catcattgtc gcctttgtga ttccggaggt attctctgtt ggtatgggaa 767821 acgccagcaa gctcaattta agcatcggca tcagcatcat tatgattctg ttatatgtgg 767881 cggcgctgta ctttaaactt gtcacgcatc ggggcgttta tcagccgaat aatgccgctc 767941 agactgaaga agaggaagag ccagaatggt cagggaaggt tgcgacgatt gtcttgtttg 768001 cggcaacgat tgtggttgca tacatatccg aaaacctggt ccataccttt cactcggtgg 768061 ctgaacagtt cgggtggagc gagctgttta ttggggtcat catcgtggcg attgtaggaa 768121 atgcggcgga gcatgcgtca gcgattatta tggccttcaa aaataaaatg gacattgctg 768181 ttgaaattgc agtaggctct acgctgcaga tcgctatgtt tgtcgcaccg gttctcgtca 768241 tctgttctat cttttttccg acaagcatgc cgcttgtatt tacattgcct gagctcgtcg 768301 cgatggtatc agcggttctc ttgatgatcg cgatttcgaa tgacggggat tccaactggt 768361 ttgaaggggc gacactgctt gctgcatatg tcattatggc gatcggcttt ttccttcttt 768421 aacctgaaaa aatgatggat aacaacaaag cgggatgaaa agactaaggg aaaatgccat 768481 agaaagagtg atatgatgaa aaagctattt cattccacac ttattgtgtt gttattcttt 768541 agttttttcg gcgttcagcc catccacgcg aaaaagcagt ttaaggttcc taattctgtc 768601 gcaagcattt caaaggaaaa cacgtatccg aatgcttcac aggatcagcc aatgcttcag 768661 ccgagcaagc tggcaaagga attgctcgat cattctgagg taaagattga aaatccgcat 768721 ctcatcaaaa tgctgaatga atccaacata tccggcacac cgcttgcagt agggtaccgg 768781 gcgacaatat ttctcgggaa atgggcgctc ggctatgaat caaatgaaac agtcgcaaac 768841 tgggaatata aaaaaatcaa tacaaaccgt gcggataacc gcggcgggaa agaaacggct 768901 gaaatgcatt atgcccagga acagcagtac agagtgaagg gcggcttgac agctaaagtt 768961 ccaaatgctg aagatgtcaa aagcatgatg atgcaaaaag caatgaagaa aacgaacctc 769021 ccgcttgcat ttgagacggt catcggggct ggcacaaaac gggatcagat ttataaagtc 769081 gctcctaaaa aaatcggtta tctacatgca tatgcaccgg ctgtgaatga aaaaggaaaa 769141 gtgacttacg gagaagtgta cttagtgctg aaaggaaata aacgaaaact cgtcgtgaaa 769201 aatgtcacgt cacagggaat cggcgcgtgg attccggttc aagatcatgt cacgtttggc 769261 tttcagcttt cctcactgcc aagataaata aaaaactgat tccaactcgg aatcagtttt 769321 tttgtttatt gggttctctc gattcggacc gcttcctcaa gcatttgcac attgttttgg 769381 tagagctggc gaacgagaac ccgtcttact gcaaggctgg cactgaaata atcatcatct 769441 ttcaccatgc ctttaaccgt aaattcgacg ccgcgattga ttttattcaa tgcggtgatg 769501 ccgtggattt gaaacggttc tgtcggattg ccgaattcat cccgcttcaa tgaatcacga 769561 agctcttcat tcagcatgtc acatgcctct tccaacacgc tgtacacgcg gtccggatct 769621 tctttaaagc tgataagaaa ggattcggta atccgcataa aatcaatatt atagttctct 769681 atttgtctga cctcgccgtt gctgatggtg agcagcttcc cgctccattc ccggatttgc 769741 agcgagcgga ggccgatttc ctccactgtc ccgttgaaca agttgttgac ggtgacataa 769801 tcgcctttgt gcagctggcg ttcatatatt aagaatacac cagccagcac atctttgatc 769861 agcgattggg cgccaaaacc gatcacgata cctgctacgc ccgccccggc caatatcttg 769921 ccgaaatcat gcacaaataa agaaataacg taaaagataa aaccaattgt tgccgtatac 769981 tgggtgacag aacggacaag gctttcaatc gttttttcct ttttttcttc aataaagtcc 770041 gtccgtttaa aaaatagctg taccagccgg ttgatgataa agacaccgat ccaaaggata 770101 acggcaacga ggagaatatc gacgatttta ttttgaaaaa tctccgtaag tgtttctttc 770161 atccgcatct aactcctggc ttgacgtttt gtgaagtctg tatcctgata ataactgttt 770221 ttgacaagaa cattcggtcc gaggcaccgg acattcgggc agtggcaact cagttctttc 770281 gcaagcttgg tctctctcca cttttcatag gcggaaggga ggctgtccgt ctgaatgttg 770341 ccaagcggcg gggtatcacc gaaatcggtc acgataatgt ttccgtcgaa aatgttcaca 770401 ttcaggcggg atcggccgtc agggtcattt cgcactgtga cgtttttcgc cgcgcgaagc 770461 cggcgaagca gcttttggtc gtcttcgtcc ggactgcagg cataaaacgg cagcgttccg 770521 aacagcatcc acgtattttc atcacgaata tccagcaagc ggtgaatggc ctgtctcatc 770581 tctttcaggc tgagggattc aagagcgctt gcgaaatcgc ttggatacat tgggtggacc 770641 tcgtgacgct gacatttcat atcttctgtg atttggcggt gaatatgctc aatatgcgga 770701 agtgttcgtt tgttcagcat cgtttccgca gataccatta ctccggcatc cacgagcgtg 770761 cggctgtttt cgatcatttt ttcaaaatag cgcgcgcgct gttcgaaggt cggttttctg 770821 tccatcatgg caaagccgat ttcagcaaaa tcttcaactg ttccccagtt atgtgaaata 770881 tgtagcacat cgagatacgg aatgatccat tcgtaccgct cgatgtcgag ggtcagattt 770941 gaattaattt gtgtccgcac accccgttca tgggcatatt tcaataaagg aacaacatat 771001 tcttttactg atttcaacga aagcatcggc tctccgcctg tgatgctgat ggatctgagg 771061 cgcgggattt cctccagccg ttttaacaga agatctattg gcagagcatt cgggtcttta 771121 ggctgcaatg tatagcctac agcacaatgc tcgcatctca tattgcacag tgtcgttgtt 771181 gtgaattcaa cgtttgtcag ctgcatgtct ccgtattggt caacatccat ataggcttcc 771241 caagggtcaa actcgggcgt aatcggacgc agcttcgtgt tttgtgtcat gactatctaa 771301 ctcctttata aatgggcata ctaacgctgc caacagttaa ttttagacct gatttgccaa 771361 gatcgcaagt agcgcggcga ttgaaaaacg gcaaaaaatg agctaccata ataaaaaatg 771421 aatggaggaa cagaatgggg aacgccgtaa acaataaaga tcagcagatt gattatttaa 771481 agaacagact tgacatgttt atgaacgtca tcgattcatt agaccctgaa gcaaccgacg 771541 ttgaagatat agacaggctt atcagcatgc ttgatgacct ggaagccaaa tacgaacgtt 771601 ttaaaaaaga ttgggaataa aaccgcgtgc ccgccgcggt ttttttattg gcataaagca 771661 acagtataaa acaaagtctc tatctgtaaa ataagaaaaa atgcagaagg agcgctggcc 771721 atgaagtgga tgtgttcaat atgctgcgcc gccgtattgc ttgccggagg tgcagcacag 771781 gcggaagcgg tgccgaatga gccgattaat tggggcttta aacgaagtgt caatcatcag 771841 ccgccagatg ccgggaagca gctgaacagt ttaattgaaa aatatgacgc gttttattta 771901 gggaatacaa aggaaaaaac gatttactta acgtttgata acggatatga aaatggctat 771961 acgccaaaag tgcttgatgt cttaaaaaaa catcgcgtaa caggaacgtt ttttgtcacc 772021 gggcatttcg taaaggacca gcctcagctg atcaaacgaa tgtcagatga gggccatatt 772081 atcggcaatc attcctttca ccatccggat ttaacgacaa aaacagctga tcagattcag 772141 gatgaacttg attcagtcaa cgaagaggtt tataaaatta cgggaaagca ggacaacctg 772201 tatttgcgtc cgccgcgcgg cgtgttcagt gagtacgtac tgaaagaaac gaaacgcctc 772261 ggctatcaaa ccgttttctg gtcggtcgct tttgttgatt ggaaaatcaa caaccaaaag 772321 ggaaagaaat atgcctacga tcatatgatc aagcaggcgc acccgggagc catttacctg 772381 cttcacaccg tatcgaggga caatgcagaa gcgctggatg acgcgattac agatctgaaa 772441 aaacagggct acacttttaa aagcattgat gatctgatgt ttgagaaaga aatgaggctg 772501 ccgtctttgt aaaagagaaa gacctctcct taaacggaga ggcttttctt tattttatac 772561 atttaatcag tgcggcccag tccagatccc cgaagccttt ctcaatcccg ctttcaaaat 772621 ggctcttggc cagctcggca agaggaagat ttgcagaaac ccgttttgcg gcggcgagtg 772681 ccaggttggt atccttcagc cctaaagaca ttttgaagcc ggccggctca aatttctgct 772741 cggccataat ggttccgtaa ttttgataga ctggagaacc aaagagcgcg ctggcgattt 772801 ctaaaaattg tttttgttct aagccgtatt tctccatcat taaaaaggat tcagataacg 772861 cctccagcat ggacacaagc aagaaattaa tgctgatttt ggctgcattt gccgtcttgc 772921 tttcttcgcc gacgtcaaat atctgctggc tcaggctgtc gagcagaggc ttggcagctt 772981 gctttgcttc cgccggtccg gctgttatga tacggagcgc ggctttggct gcggcatccg 773041 gtctgccaag gacaggagcg gcgagaaaaa attgtccttt ctctgcatga gccgctgcga 773101 gcttttctga gaactcaaca ctgattgtgc tcatcgagat gtgtatgccg ttctctgcta 773161 atccttcaag cagcccgtct tctccgaatg tcacggtgct gacagaatca tcatctgcaa 773221 gcattgtgat gacaatatca gcggactttg ccgccagccg cggcgtatca gctgcctgtg 773281 cgccttctgt gacaaggtct tctgtctttt gtttcgtccg gttatagaca gtcaattcgt 773341 agcctgcttg aagaacattt cgggcaatgg gctgtcccat attgccgagt ccgatgacag 773401 caattttcaa tctaatcact ccctgaatat tttttccatt ataaacaata tgaacagaat 773461 atgcatagcg atcggcttac aacaaaaaag aacagctgct cgctgtcctc atttaaaaat 773521 attgaaccat cctttatgta caaaccaaat cagcattcca atcacaagcg cggccatcag 773581 gccaagtaca gcgaaatatc cgtatttcca atgcagctcc ggcataaagt cgaagttcat 773641 accgtataca ccggcaataa aggtgagcgg gatgaaaatg gttgatacga tcgtcagtgt 773701 catcataatc gcattcatcc ggtttgagtt tagcgtcacg tagctgtcac gcaagtcgga 773761 cgtcatgtca cggttggatt ccacaatttc agacaacttt aacaaatgat catatatgtc 773821 gctgaaatag gctttcgttt cccgctgctc tttcacatgg tcaaggctta aaatccggta 773881 gagcaaatca cgcatcggga taatcgtccg tctcaaatgc aataggtctg ttctgagatc 773941 aaacacctcg ttcatcagcg ttccatacgt tttgtgggga cggctttctt caatttcatt 774001 cagccggtct tcaattttat acacgagagg aaaatattca tcaacaagct gatccatgat 774061 catataagaa atatgcccgg gccctttttt caatatgtcc ggtgaagcat acaaacgctc 774121 ccggacttta gcgataccgg gcgtttcgtg taaatgaaag gtgacgacaa atttttcgcc 774181 ttgaaagata tcgacttcct ccgtctcaag tgtttcctta ttcagcgcat gaatcacgta 774241 aaaacgatag ccgtcataat ggtcaagctt tggccgctgc atatgctgga agcaatcctc 774301 aatggcaagc gggtgaaaat gaaaaaaatc tctcaataac gccgtttccg tatcctccgg 774361 gccgtaaaaa tcaacccagt accatgcaat atcaggctgt tccactcgtt cgatcggtat 774421 atttttcagc agctgatgct ctgttgtgat tgcggtaatg ttgatcataa acaaccctcc 774481 acctgccatt atatcatgcg gtctttatga gaaaagtata cggtactctc tgcctaattc 774541 cagcggcatg ttatactgaa caaaaacgga aaaaagggtg gatctcatgt ggaaggaaaa 774601 agtatctgtc acgcctccgt atcattttga ccgcgtgctg gacaggctgt ctttagaccc 774661 cctcaatgct gttgatcgag aggcgaggga agtccgtgtg ccaatcagaa atcaagcggg 774721 ggacgtatgt attgtaaagg tacaggcgtt aggccatgcg ggcgagcctg agttcctcgt 774781 cagcggggaa acggatcagg gagaaatgat gaaggaaatc aagcggattt ttcaatggga 774841 aaatcatttg cagcacgttc tggatcattt ttcaaaaacg agcctgtccg ccatttttga 774901 agagcatgcc gggacgccgc ttgttctgga ctacagcgtg tacaactgca tgatgaaatg 774961 cattatccac cagcagctta atctttcctt cgcttacacg ctaacagaac ggtttgttca 775021 tgcgtttggc gagcagaagg atggcgtgtg gtgctatcca aagccggaaa cgattgcgga 775081 actcgattat caggatctgc gtgatctgca attcagcatg agaaaagcgg aatacaccat 775141 tgatacatca aggatgatcg cagaaggcac actcagcttg tcagagctgc cgcatatggc 775201 ggatgaagac attatgaaga aactgatcaa aatcaggggt atcggcccgt ggaccgtgca 775261 aaacgtcctc atgttcggac ttggccgtcc caatttattc ccgcttgccg atatcggcct 775321 ccagaatgcc atcaaacgcc actttcagct ggacgataag ccggcaaagg atgtcatgct 775381 ggcgatgagc aaggagtggg agccttattt aagctatgcg tctttgtatt tgtggaggag 775441 tatagaataa ttcgtctgac aatgaaggaa atcctgcaaa cgtgttatac tagaaagatg 775501 tgaaaaaacc atttcacttt ctgccatccg cagaaagctt catatagaaa cggagagaac 775561 aacgtgaacc aacaaaagaa acaggcgccc gtcgaactga aggtcggaca aacttttccg 775621 ctgacgatta agcgtctcgg cattaacgga gaaggtgttg gctattttaa gaaaaaagtc 775681 gtcttcgtgc ccggcgcgct tcctggcgaa gaagttgttg tgcaggccac aaaggtccag 775741 ccgaagtttt cggagggccg cattaagaaa atccgcaagg catctgagca ccgggtggca 775801 ccgccttgcc ctgtttatga acaatgcggc ggctgtcagc ttcagcacct tgcatacagc 775861 cagcagcttc gggaaaaacg tgatatcgtc attcagtctc ttgaacgcca tacgaagttt 775921 aaagttgaaa acatggaaat caaagaaacg attggcatgg acaacccgtg gaattaccgc 775981 aataaaagcc aattccagat cgggcgctcg caaagcggca gcatcatcgc cggcttatac 776041 ggccttgatt ctcatgatat cgtgccgatt aaagactgta tcgttcagca tccggcaacg 776101 aacaaaacaa caggcatcgt ccgccgcatt ttagaggact tcaatgtgtc tgtttataat 776161 gaaagaaaac gaaaaggcga cgttcgcacg atcgtgacga gagtcggctt tgaaacaggc 776221 gaagtgcagg tcgtgcttgt aaccgcaaaa gaaacgcttc cgcacaagga agaaatcgtc 776281 aaagcgattc aaaagcgatt gccagaggtc aaatccatta ttcagaatgt aaacggggcg 776341 aaaacctcag tgatttttgg tgagaaaaca aaacagctcg ccggaaaaac agtgattcaa 776401 gaagtgctcg gcgacgtatc ttttgaattg agcgcccgcg ctttcttcca gctcaatccg 776461 gaacagaccg tcaagctgta tgatgaagtg aaaaaagcgg cgcagctgac cggaaaagaa 776521 aaagtcgttg atgcgtattg cggcgtcggc actatcggca tgtgggttgc ggacggagcg 776581 aaggaagtcc gcggcatgga cgtcatcaag gaatcaattg acgatgctaa gaaaaacgcc 776641 aaaaaacacg gcatggcaaa tgccacatac gtaacaggaa cagccgagca ctggctcccg 776701 aaatggacga aagaaggctt ccgcccggac gtcgtcattg tagacccgcc aagaacgggc 776761 tgtgacagca cgttcttgga cacgatcaaa aaagtcaaac cgaaacgctt tgtctacgtt 776821 tcctgcaatc catccacgct tgcgaaagat ttgcagacgc tgtcgaagga ctatcgcgtg 776881 gactatattc agcctgtcga tatgtttccg cagacggcgc atgttgaagc agtggcgagg 776941 cttgtattaa aatcgtctaa ctaaaaagaa catttcccag tcataaaata gttttcctaa 777001 taagacctgg atttcggtaa aataaacaat tccgatttcc gggtcttttt cgtgcgcagc 777061 tcttgtccta acggtctgtt ctcaatttta tcttccttct tttcgcggag atctttattt 777121 taactggcga aaagaattga aaaaacgtgt tgaaaagcag gtgaaaaaaa gcgttattta 777181 accggaaaaa tatcctccca gtatgtttaa aatacatgag tagaatgatg taaaatcata 777241 gatgtatttt cataatttgt aaaattatat attgacttgc agttattacg tgtgaaatat 777301 tgatgatagg aatataagga aagtatggcg tatatcattt caagagtcat tcgatgtaaa 777361 aagttgaaac attgtaataa atgaaagagg tgaaaatgat ggccaacccc attttaaaat 777421 gcataacgta tgagcactac aacaattaaa taatagtgcc gagacgataa caactattac 777481 agtaatacct acaatggtta tatccttgcg acaatcatgc ttcataatat aatgatttta 777541 gattgacact tggctaaaaa gtattgcaga gaaggaaatg gataattaaa tggataaagt 777601 atataaaaga agttggtttc aaacattttt ggcattttta gtatctcagc tttattttaa 777661 ttttgtagaa ttaacgggat ggggtcctaa gtatagagaa atgaatggat tcccagcaaa 777721 catagttgaa ctagatttct ttcaaacata tctttcattc tatgataatc catggtttaa 777781 tattattact gttttcttgg gagttttcac tattatacaa ataattacag ggataacaaa 777841 ggatattcga aattaaagca ataacttctg atgccttatt taatgatgaa agaaaatgta 777901 cactttctta attatcttat gagtgaagac tgcgacactt agtcagcagt ctattttatg 777961 gttctggatc aggattaccg aattataacc ctatacaaat atatagtagg ttgccacttg 778021 ctgcgttggt tattttctaa atcatgagca aatcccaaat gattcagatt gaagttcttg 778081 aattctttta aataagggtt tattttctct tctcatcctc tttactccat gtgattcaca 778141 agtggtagca gcttaagtag gttttttcat tctcttgagt actcagttat accaccccca 778201 actcaatttg ctttatctct attagttttt ccgcaaatat gatatagaga tacggatatg 778261 gtgtagtgtt aaatatctta tcttcaataa cagggcaatt attttgcgtt ggtaatatgg 778321 agaactcata tgatattcta tttaggttgg aatccttttt atccaaaaag ttcaaaagca 778381 aggccactaa gaaagacgaa ggtcagcgcc agttaaccag aatataaaaa atagggtaga 778441 taatcatccc acgtgaaatc ttcaaaattt actatagatt gataagaaat gctttcgcat 778501 gcgataagtg taaaagaagc atggtcagtt tttaatttgg gataaaggtt cagccgtatc 778561 ccataatgaa aggatttgat ttttgttatg acagaaaatt tctggcgtga attaccacgg 778621 ccgttttttg tactggcacc aatggaagat gtgacagatg ttgttttccg gcatgtagta 778681 agtgaagcag gcagaccgga tgtgtttttt acagagttca caaactcaga gagctattgc 778741 cacccggatg ggaaggatag cgtgcgcggc cgtttgactt ttacagagga tgaacagcca 778801 attgtggccc atatatgggg agataagcct gaaaacttcc gtaaaatgag tattggcatg 778861 gcagagttag gatttaaagg actagatatc aatatgggct gccctgtgcc taatgtggcg 778921 gggaatggaa agggaagcgg ccttatttgc cgtcctgcag ttgcggcaga attaatacaa 778981 gctgcaaaag cagggggatt gcctgtaagc gtgaagacaa gacttggata cacggatgtg 779041 gatgaatggc gcgagtggct gacacacatt ttgaaacagg atattgcgaa tctttctatt 779101 catctgcgta caagggcaga aatgagcaaa gtagatgcgc attgggagct catcccagag 779161 attaagaaac ttcgtgacga ggtggcacca gatacattgc taacaataaa cggggatatt 779221 cctgaccgtc aaactggctt gaaacttgct gaacaatacg gcgtcgatgg aattatgata 779281 gggcgcggta tttttacaaa tcctttcgct tttgaaaagg agccgaaaga gcatagcagc 779341 aaggaattgc ttgatctctt aaggctgcat ctggatctcc atgatgaata ttcaaaagaa 779401 gaagcccgtc catacaagcc tcttcctcgc tttttcaaga tttatctccg cggattccga 779461 ggggcaagtg aattaagaaa tcaatgcatg aacacaaagt caacagatga agtgcgtgca 779521 ttgctcgacg actttgagag aaagtatctt gatgggatag agtaacagca gtgcttgatt 779581 caaaaaaggc taacaaaata aagggatttt tacacaattc ttgactaaaa taaacctgga 779641 ttttcggtaa atccgggtct tttttgtacg cagcttttac tcagcctgtc ttttctctaa 779701 tttattgtaa gaaaataatg gtatatttag tggagatatc atataaaggg ggagaggaaa 779761 atgaaacggc tatgcatcat cccctgcggc aagaaaaaaa tctgggatgt ccagcctgat 779821 gccgggccgg taagagcaga ggacgcttat ctcagcccgt ttcatcaggc gtgcgagcgg 779881 tatgcaaaaa catttttcga tgagtgggtg attttgtcgg cgaagcacgg gttcctccgc 779941 cctgatgatc tcgtttcggg aaattacgat gtcacttttg gcaccggtca tccggaaatc 780001 atgacagcgg acgagctgcg ccgtcaattt cacgaaaaag gcttttctga tatcgaagag 780061 ctagtcatgc ttggcggaaa aaaatatcga agcgttctaa acgccgtcat cggagaacac 780121 cagcatatca gctggccgct atcatcatac aaaggcatag gctatatgct ccaagcgctg 780181 aaccgggctg ttgaagaaaa gcatgaactg tagcacgtac atatgaggaa aagagtggga 780241 acatgaaaaa acttgtgttt ggcttgcttg ccattgtgtt attcggatgc ggactatata 780301 tctatcatgt atggttcggt gatccatttt cgaaaaatgc tgcagaacag aagctagtgt 780361 cttatgtgaa acaaacctat cctaagaaag aaatcaagat cacgaatggg gtatataacg 780421 ctaaaacgtc tgaatatgta tttgaagcaa cctcccaatc tcatcgctac ccaatgtgta 780481 cgaagggatt tctgcatcct aaagtaacgt gcgatggaat tgaagaagcg tataccgaat 780541 cagtagcaaa acatgtaaat gaagaagcaa cgaaggcaat cgaagcagat ctgaaaaaag 780601 cggttcctcg atttataaaa gctgatgctg ctttgagtat cgaaaacgga cagttcacgt 780661 tagatacaaa atggaacaaa aagctggctg aaaaagcgcc tatgagcatg acgattcagt 780721 tagacgccag cgggttatca aaaacagatg ccgcaaagat ggcggaaacg gtcagaaaaa 780781 cgcttaatga aaagggatat acatactcaa acggcacgat agactgtatg cagaaggacg 780841 gggacggcgg tattggatat gtcaaatatt caattgattt tctttcaaaa gcagctattc 780901 agtcaaacga tgcagaggaa ctaggaagtt aaaaagattt ccaaggaaat aaatacgtcg 780961 atcattgtca aaggccgggt gatatccggt cttttttttg catgctgtaa aacgagacaa 781021 atgaatcagt ttgagacaaa acgagacaca cgtctcaaac tgtctccaaa gtgaagatga 781081 gaagactgat tttacgggct caaaagactg gcacacttct tgcatttata atggtgaacc 781141 ctaaatagaa ggaggcgcac aaaatgaaat tgttaaaacg agaaggcttg tcattaactg 781201 aggaaaaagc gctgtggatg taccaaaaga tgctggagat caggggcttt gaagacaaag 781261 tgcatgaact gttcgcccag ggagtgcttc ccggattcgt tcatttatat gccggtgagg 781321 aagccgtggc tgtaggggtg tgcgctcatt tacatgatgg cgacagcatt acaagcaccc 781381 acaggggaca tggacattgt atcgccaaag gctgtgacct ggacggcatg atggcggaaa 781441 ttttcgggaa agcgaccgga ttgtgcaaag gcaagggcgg ttctatgcac attgcggatc 781501 ttgataaagg catgttaggc gcaaatggaa tcgtcggggg cggctttacg ctcgcatgcg 781561 gatcagcgct cacggctaaa tataaacaga ctaaaaatgt aagcgtttgc tttttcgggg 781621 acggggcaaa taaccaaggt accttccacg aagggctgaa tttagcggct gtatggaacc 781681 ttcctgtcgt atttgttgct gaaaacaacg gctatggcga agctacccca tttgagtacg 781741 catcagcctg tgattcaatc gccgatcggg cggctgctta taacatgccg ggggttacag 781801 ttgacggcaa agatatttta gcagtttacc aggcagccga ggaagcgata gaaagagcaa 781861 gaaacggcgg cggcccgtct ttgattgaat gtatgaccta cagaaactac ggccatttcg 781921 aaggagatgc ccaaacctat aaaacgaagg atgaaagagt tgagcacctt gaagaaaaag 781981 atgccattca aggttttaaa aactaccttt taaaagaaac agatgctaat aagctgtcag 782041 acattgaaca gcgtgtcagc gaatcgattg aaaaagccgt ctcgttcagc gaagacagcc 782101 catatccaaa agattcggag ctgctgacag atgtgtatgt gtcatatgaa aaaggaggaa 782161 tgtaagagat ggcgagagtc ataagcatgt cagacgcgat caatgaagca atgaagcttg 782221 cgatgagaaa agacgaaaat gtgcttttga tcggtgagga tgtcgccggg ggagcggcgg 782281 tcgatcattt gcaggatgat gaagcatggg gcggtgtatt aggggtcaca aagggactcg 782341 tacaggaatt cgggcgtaca agagtgctgg acactccgat ttctgaggca ggctatatgg 782401 gagcggctat ggctgcggca tcaaccggtt tgagaccgat tgccgagctg atgtttaacg 782461 attttatcgg cacgtgcttt gatcaggtga tcaaccaagg ggcgaaattc cgttatatgt 782521 tcggcggaaa agcgcaagtg ccgattaccg tccgcaccac atacggagca gggttccggg 782581 ccgctgccca gcattcacaa tcgctgtatg gccttttcac gagcatccct ggactgaaga 782641 cagttgttcc atccaatccg tatgatgcca aaggtctttt gcttgcagca atagaagata 782701 atgatccggt gtttttcttt gaagacaaaa cgtcctacaa catgaagggc gaggtgccgg 782761 aagattatta tacaattccc ctcggaaaag cggatatcaa acgcgaaggc aatgatgtta 782821 cgctctttgc agtcggcaag caggtcaata ctgcgcttga agcggctgca cagctttcag 782881 agaggggcat cgaagccgag gtccttgatc cccgcagtct gtctcctctg gatgaggatg 782941 cgattttcac atcgttagaa aaaacaaacc ggctgatcat cattgatgaa gccaatccgc 783001 gatgcagcat tgccacggat attgctgcgc ttgtcgctga caagggcttt gatttgcttg 783061 atgcgccgat taaacggatt acagcgccgc atacaccggt tccgttttca ccagtgcttg 783121 aagatcaata tttgccgaca ccagataaaa ttgtcagcgt cacgcttgaa ttgcttggcg 783181 agccggcatt gaattaaagg ggggacacaa atggcggtaa aagtagtgat gccaaaattg 783241 ggaatggcca tgaaacaagg ggaagtatcg atatggaata aaaaagtagg cgacccggtt 783301 gaaaagggag aaagcattgc cagcattcaa tcggagaaaa ttgaaatgga gatcgaagcg 783361 cctgaaaaag gaacgctgat cgatatcaaa gtgaaagagg gagaagaggt tccgcccggc 783421 acagctatct gctatatcgg ggacgccaat gagtcggtgc aggaagaggc gggggcgcct 783481 gttgctgaag acaatatgcc gcaagccgtc cagcccgtca aacaagaaaa caaacccgca 783541 gcctccaaaa aagatcgaat gaaaatatct ccagtcgcca ggaaaatagc agaaaaagca 783601 ggattagacc taaaacaact gaaaggaact ggaccaggcg gacgaatcgt gaaggatgac 783661 gtaacaaagg ctcttgctga acagaaaaaa gatcaagcaa agcctgtttc ggagcagaaa 783721 gcgcaggaaa tcccggtgac aggcatgaga aaggtcatcg ctgcccgaat gcaggaaagc 783781 ctggcaaaca gcgcgcagct gacgatcacg atgaaagctg atatcaccaa gcttgccact 783841 cttcaaaaac agctttcacc aactgcggaa gagagatacg gcacaaaact gacgatcact 783901 cattttgtct caagagccgc cgttctcgct ctgcaagctc accctgtgct gaacagcttt 783961 tatcaaaatg agcgcatcat cacacatccc catgtgcacc ttggtatggc tgtagccttg 784021 gaaaatggct tagtggtgcc tgtcatccgc catgctgaaa agctatcgct gattgaactg 784081 gctcaatcca tctcagaaaa tgccaaaaaa gcacgcgagg gacgtgcggg aagcgaagaa 784141 ctgcaaggat ctactttctc cattacaaac cttggcgcgt ttggagttga gcatttcaca 784201 ccgatactaa atccgccgga aacaggcatt ctcggcatcg gagcaagcta tgacacaccg 784261 gtgtatcaag gggaggagat cgtcagaagc acgatcctgc cactcagcct gacatttgat 784321 cacagagcgt gtgacggcgc ccctgccgct gcattcctga aggcgatgaa aacatatttg 784381 gaagaacccg cagcattaat tttataggaa aagcaggtga aaacgacatg acattagcca 784441 ttatcggcgg cggacctgca ggctatgcgg ctgcggtttc cgcggcacag cagggcagaa 784501 acgtgctgct cattgacaaa ggcaagcttg gggggacctg cctgaatgaa ggctgcatcc 784561 cgacaaagtc tttgttagaa agcgcaaacg ttcttgataa aatcaagcat gccgacagct 784621 ttggaatcga acttccggca ggtgcgatat cagtcgattg gagtaaaatg caaagccgaa 784681 aacaacaggt tgtcagtcag cttgtccaag gcgttcagta cctaatgaag aaaaatcaaa 784741 tacaggttgt aaagggaaca gcctcctttc tttctgaaag aaagctcttg atcgaaggag 784801 aaaacggaaa agaaatcaga gaggcggacc aagtattgat tgcctccggg tcagagccaa 784861 tcgagctgcc ttttgcccca tttgacggcg aatggatcct cgacagcaaa gacgcgcttt 784921 ctctttccga gattccgtct tcactagtca ttgtcggcgg cggtgtcatc gggtgtgagt 784981 atgcagggct gttcgccaga ttgggatcgc aggtgaccat cattgaaaca gcggaccggc 785041 tgatcccggc tgaagatgaa gatattgccc gtctctttca ggagaaactt gaggaagacg 785101 gtgtcgaagt gcatacttca tccagattag ggcgggtgga tcaaacggcc aaaacggcaa 785161 tatggaaaag cggtcagcga gagtttaaaa cgaaggccga ttatgtgctg gtggcgatcg 785221 gcagaaaacc ccgtcttgac ggattgcagc tggaacaggc cggagttgat ttttctccaa 785281 agggcattcc ggtgaatggg cacatgcaga cgaacgtgcc tcatatttac gcgtgcggag 785341 atgctatagg gggcattcag ctcgcgcatg ccgctttcca tgagggcatc atcgctgctt 785401 ctcatgcttc cggaagggat gtcaaaatca atgagaaaca tgtgccgcgc tgcatctata 785461 cgtccccgga aatcgcgtgt atcggaatga cagaacgaca ggcaagaagc atatacgggg 785521 atgtgaagat cggcgaattt tcattttccg caaacggcaa ggcgctcatt aaacagcaag 785581 cggaaggaaa ggtcaaaatc atggctgaac cggaattcgg cgaaatcgtg ggtgtctcga 785641 tgattggccc ggatgtaacc gagctcatcg gccaagcggc agcgatcatg aatggtgaga 785701 tgacggcaga tatggcggag cattttatcg ccgcccatcc gactttatcg gaaacattgc 785761 atgaggcgct gttaagcacg atcggccttg cggtacatgc ataataaagg aaaaagcagg 785821 cgcatggata taaggcgcct gcttttttat tgttgaaagc gctttatttt tcccctacaa 785881 tagatgaaaa cggcgtgtaa gggaggagcg atcaaggaaa tgaattcggt cccaaacgat 785941 ttgcaaacct ggaaacgttt tgtgaaagac ggtgtgcttg acgaagcccg attaagaaaa 786001 cggattgcag agtcatggca tcgctgcaaa aaagctgagg tcaatcctta tttagaaaaa 786061 ggcccgaagg ttttacagca aacggagctg gatcagcagt caaaaaaaca ttcattcttc 786121 ttgacgaccg caaagcctta cctcgaaaaa ctgctgcctg ccataaaaga aatggaaatg 786181 atggcgctgt taattgattc agacggtgtt gttctggcat tggacggcca tccgcgcgcg 786241 ctctatgaag ccaaacgcat caatttcgtc gaaggggcat gctggacaga aacggctgtc 786301 ggaacaaatg cgattggcac ggcgctccac atcagcgagc cggttgcaat acaaggatca 786361 gagcattact ctatcgcttc ccatctttgg aactgttcag ctgctccgat tcaccatgag 786421 gatggcagcc ttgcgggtgt aattgacata tcatgcccgg cggcaggcgc gcatcctcat 786481 atgcttggta ttgccacggc gattgcctat gccgctgaac gggaactcgc agctaaaagc 786541 cgtgagaaag agctggagct gatcagccgt tttggggaga gagctgcatc cagtgtgccg 786601 atggtgctct gtaataccaa gcagcacatc atcagtgcga gcatgccgat tcgaacctca 786661 atgccggatt ggcagggccg gcacctgtac gagttgaagg aacggggcta ttcaatcgaa 786721 aatgctgtca ccataggaga tggcggcact tgtttttatc tttcggaaca aaagaaaaag 786781 aaggcgtttc gattcaatgg agtgatcggg caaagcggcc gatcgcaagc gatgctgatg 786841 caccttgaac gagcagctgc gacggatgca tcggtctgtt tgtcgggtga aacgggtacg 786901 gggaaggagg tcgcggctcg cgcgcttcat gagaacagtg agagacggca cggtccgttt 786961 gttgctgtca attgcggagc gattccgtct gatttgattg aaagcgaact gttcggatat 787021 gcagagggcg cttttacggg agcgaaacga aatggctata aaggcgcctt tcaaaaagcg 787081 aatcaaggca cattattttt agatgaaatc ggagaaattt cccactcgat gcaggttgca 787141 cttttacggg tgcttcagga acgcaagata acgccaatcg gcgggacgaa agaaattccg 787201 gttgatatca gagttattgc cgccacacat tgtgatttac gcgagcttgc cgaaaacgga 787261 aaaatcagag aggacttgtt ttaccgtctt catgtctatc caattgaact ccctccatta 787321 cgcgatcgca ccgaggatat cccggatctc tttgagtact acaaacagaa gaatcattgg 787381 ccaggcgatc ttccttctga tttttgtaat gtgctgaagc aatggaagtg gccggggaat 787441 atccgcgagc tgtttaatgt gtttgaacgt ctttctatca gatttccgga cggccggctg 787501 agagatgaat cgcttcccgc tttactggaa gccgctggat tgccggccag ctctgcagaa 787561 aaaaagccgg ctgctgccgg cgtgcttact tttcgtgagc aaatccaaaa ggatatgatg 787621 atcaaagcgc ttgaatctgc aaaaggaaac gtctctcaag ccgcaaaaat cagcgggatc 787681 ccccgaagca ctttctacaa acgcctgaaa aaattcaact tgtccgctga atcataaagc 787741 atacttcctt caggaaatgg aaacgttatg tattgaagga gggtgttacg atgaatattc 787801 aaagggcgaa agaaattgta gaatctcccg acatgaagaa agtaacatat aacggcgttc 787861 ctatttacat tcagcacgta aatgaagaaa ctggaacagc aagaatttat ccgcttgacg 787921 aaccgcaaga ggagcatgaa gtgcagctga acagcttaaa agaggattaa acaaaaatgg 787981 cccgcttcat aagcaggcca ttttgttatc cgcgcggcgc aaataaaata acacagacac 788041 cgatgagaca aatgaatgcg ccgatccagt catacagatc aggtgttttc cggtcaacaa 788101 gccatcccca caggaccgca agcacgatga atactccgcc ataagcggcg tatacacggc 788161 cgaaagatgg gaaggactga aacgtcggaa gaatgccgta tacaatgagg atcagcgccc 788221 cggcgattcc gtagccagct ggctttgcct ctctcagcca tagccaaacc agatatccgc 788281 cgccaatttc agcaagccct gccgcgagaa ataaaagaat ggtaatcagc atcatgagca 788341 ctcctcaatt tgcatttatc tttcattata gaggaggaga gcttttaaag cttcggatga 788401 ttctcaaatt ccttcaaata cgcttttcgc tgaacctctg taaattggct gatccaattg 788461 ttttgagcct cttcattcaa atggggaagg atatagcgtt caaccgcttc gaaaaacagc 788521 ggattcgtga tgatgttcca ggtcgggatt cgaacgattt tgccgtctgt tttctcgatg 788581 ataatatcct caaaaaagat ccctttcaaa ctgtattgat ggcgtcccat ataaagccgc 788641 ttcacctcgg aaaacagcac gctgcgcttt ctcaagaaga tttcgccact aggtccggtc 788701 tttatggtga aaatgacatt tccacggctt gtgaacgcag gaaaagccat aaagaatgtg 788761 atcaatccat aaatcatcgc cagtaatccg ccgcccaaat aaagcagggc atatttagat 788821 tcaaacgtga gggcttcaga caccagccag actcccacaa taaaggcgcc ccctgtagcg 788881 aggaacagcc aagcccttag aaacatcatg ctttttactt caatcatgtg ctgcccctaa 788941 agcttcggat gattctcaaa ttccttcaaa tacgcactgc gttggatgtc tgtaaactgt 789001 ccgatccaat tgcttttcgc ctcttcattc agatgtggaa ggatatagcg ttcaaccgct 789061 tcgaaaaaca acggattcgg aatgatgttc caagtgggaa tgcgaatggt cttctgatcc 789121 acggtttgga tcaatatatc ttcttggaag attcctttta gactaaattt atggcggctc 789181 atctcaattt tcttgatatc agtaaacgta acagacactt tgtcagtgaa cacttctcca 789241 ttttttcctg tcttgatgcg gaaaatggta tttccccgcg gggtgaaagc cggaaagaag 789301 atgataaata aatataaaca aaacaaggtg aacagaaagc cagcaggaat ggctaatagg 789361 taatatttcg tttgaaacgt aatacccata taaaagagcc acaaacatgc taatcccata 789421 ccggcagatc cgacaaaagc ccatattctc aggaacattt tgcttttgac ttcaatgatt 789481 tcttggtttt tcaatgcttt tctccttttg ttaattcaat tcttatcatt ttgaaatgat 789541 ttgatttaca acatccttat gagcagggag gatagaaaat tcattctggg tgatgcctgt 789601 gacaagccaa gtatggtggg cccccggcag gacgaatgcc atgtcagcca cttcaggagt 789661 gttatctttt ccatatgcca gacgcataag tgtatccatt ttccctttcc gcaaagccag 789721 atcatttgca aatcgggtaa cgtcctcttg gtggtcatgt ttttcaagga actcttttag 789781 atatgaaggg ttgtctgaag cgccctccaa gagtttttca aattcatttg atgtcaatgt 789841 tacaatcgat tctcttttat cctctgtatc tattatatgt aaaaactcat ctgtcttagc 789901 aagtaaccct tcacttgatt ccatttttgt aatgcgatgg acttgttcat caaaaaggag 789961 ttcgtgagag taggtgccga attttgatac atggcatgac acattctgtt cggcaccttg 790021 cccgttaaat ttagaaagct tcactgtata gtcagcgtcg tttaatacat ggataaacgg 790081 acagtactcg tcctttaacc gatattgatg gttccgatat tccgctgcat ccttggctaa 790141 gagtgagcgg cacgcggctt caaataaggc gccgagctgt tcatcttcta tttccggaaa 790201 ataggcctgc ttcaaggcca ttccctgttc aaaaaaccct tcgctgtaaa agcaaaacaa 790261 gagttcttct atgctaattg taaactgctt cattgtttat tctcctatcc aaatgaaaat 790321 ttccctttaa ggaaatgggt tgcgccgtgt ataagcgaat ccgctgtttt ctttgctttt 790381 tccattcctt ttttcgcgct gtctatccct ttatgtatcg atttattcgc cgcatctatg 790441 ccgtcattca ctgatttgac gactttgccg gctgattcca gccctttttt ggctgtatca 790501 acaacagcat ggatcggttc tttcagcttt aaggctgctt tttcagcaaa accggctgta 790561 tatttggcga tttgttctcc gacgactccg ccaatgtatg aacctgctgc cccaagaagg 790621 acagtaccca caggtcctgc aaagcttccg attgcaccgc cgatgacagc accagctgtg 790681 gcaccgccgg caacaaaaat cgtattattc acagcattcc cgacggcctt ggcgttttca 790741 cgcttgagaa cttccggttt atcctggtat tttgcataat tttcagcaat tttcacgcct 790801 gctccgaatg tttcggtcgc tccggtaatc agtgtggcgg taatggcatt tcctttcgcg 790861 aatctcaagc ccgtttttcc cacatccttc aaagtggagc gtacgccggc ttcattaaga 790921 aatccttttg tgtagcttct gacgctgttt gaaaaatcca ccgtgtcctg aggaaagtat 790981 tttgtaaact ttttatgtac caaatctgaa aatggacggt ttgtcttttt caacaaatat 791041 ttaggattca aaagcactct tgccgctttt tgataacgtg agctgtcaac ggccctggaa 791101 atatccaaga gcagttttga gtgctgggct gtatgcaagc cgcttggttg tttcacaaat 791161 ttcgtaagcc ctaatccgta atattttccc tgcgtcagca taagagcggt taagcttgtc 791221 atcgtaccgt atttgtcgta ggcattgtag agctttcgca aaatatcatc ttgttccaca 791281 aatttatcgc ctgtttttct gatgaaaatc tcattgtcac tcagcttagt gacgagcgcc 791341 tttcctgagc tccacgcatc gcccactcca gaaaaacagc tgctgtagcg gggatcgcat 791401 tgcaaaatca tctgccccag ctccacatgc aggtccttat atttgttttc catatcagtt 791461 aattcagtga ctacatcatt tgcaagctgt tcgagcttat ccggatcaac tgcaatgttt 791521 cctgacacac cgttcacctc ccgagtttat gtctttcctc tcttgcttta cgctccagtt 791581 cttccattct ggcaatttca gcttttcgtt cttctatttt gacagcggca gccttcagct 791641 cttggcttgt ttcaagcagc tcctgttcga attgatcgta ggcggctttc gtttcctcga 791701 aatcctggtc aaacgaatct cttgctttgc cctgccaagc atctcccaat gcagataacc 791761 gggattcaag cagcattttg gagcttctga cctcttctgc ggccgcacta tacttgtttg 791821 ccagctcaat gactttatat gagtccaact tttgtcccct gccttttcta aattcacgca 791881 caattggatg ttttatataa atgattataa ataattcggc atgtatccga atcgtacaaa 791941 agaacctttt cataagaatt ggaagggcgt atattcactt aaaattcaca gttggtgaga 792001 ctttaagatt acaaaaaagg taaaaaaacc aaatctctca gacataaggc aaatgagaaa 792061 tttcccgctc tatgggaaaa aacactaaag ttgatcaaat gacctaagtg cgccaaacgt 792121 gttacgggac gagctatctc atggtataaa tggaattgta aacgttatca aggaggtcgt 792181 catatgaaga aaaaatcatt ctcaatcgta atagcgggcg gagggagcac tttcactcca 792241 gggatcgtac tcatgctctt ggaccatttg gaggagtttc cgatcagaaa gctgaagctg 792301 tatgataatg ataaggagag acaggatcga attgcaggcg cctgtgacgt ttttatcaga 792361 gaaaaagcgc cggatattga atttgcagcg acgactgacc cggaagaagc ttttacagat 792421 gtcgattttg ttatggcgca catcagagta gggaaatacg cgatgcgcgc gcttgatgag 792481 caaattccgt taaagtacgg agttgtcggc caggagacgt gcgggccggg cgggatcgca 792541 tacggtatgc gttcgatcgg cggtgtgctt gaaatattag attacatgga aaaatactcg 792601 cctgatgcgt ggatgctcaa ttattccaat ccggcggcaa ttgtggctga agctacgaga 792661 cgccttagac cgaattctaa aattctcaat atctgtgata tgccggttgg gatcgaagac 792721 cggatggcgc aaattcttgg cttatcctca agaaaagaaa tgaaggtccg ctattacgga 792781 ttgaatcatt tcggctggtg gacatcgatt caggatcaag agggcaacga tttaatgccg 792841 aagctgaagg aacatgtatc ccaatacggt tatattccga aaacagaggc tgaagctgtg 792901 gaggcaagct ggaatgacac gttcgccaaa gcgcgtgacg tgcaggctgc agatcctgac 792961 acactgccga atacgtattt gcaatattat ttgttcccag atgatatggt gaaaaaatca 793021 aatccgaatc atacgcgggc gaatgaagtc atggaagggc gcgaagcttt tattttcagc 793081 caatgtgaca tgatcacacg tgaacagtcc tcggaaaaca gcgaaattaa aatcgatgac 793141 cacgcatcgt atatcgttga tcttgcccgg gcgattgcct acaacacagg tgaaagaatg 793201 ctgttgattg ttgaaaataa cggtgcaatt gcgaactttg acccgactgc gatggttgag 793261 gtgccatgca tcgtcggctc aaatggacct gaaccgatta ccgttggcac cattccgcaa 793321 ttccagaaag ggctcatgga gcagcaggta tccgttgaga agctgactgt tgaagcgtgg 793381 gcagagaaat cgttccaaaa gctgtggcag gcgctgatcc tgtcaaaaac agtgccgaac 793441 gcgcgtgtgg caagactcat tcttgaggat ttagtggagg ccaacaaaga cttctggcct 793501 gagcttgatc aaagcccaac ccgcatatca taaatgaaat tcccccattt tcgaatctgt 793561 aattgtatat aatagaaaga aaatgggggg atctgatatg cagctcgaag aactgatcaa 793621 tcagcactac agcaaattga atgacaacga ttttcatatt ttaaaatata tattgaatca 793681 taagcacaca tgctatcacc ttggaatcga cgcgctggcc aaagcttgca gtgtatcgcg 793741 ttcctcaatt ttacggcttg cccaaaagct cggtttcagc ggttacagtg aatttcgcgt 793801 ctttttaaag tgggaagatc agccggaaga aggcgagagt atgagttttg aaaagctgct 793861 tgatgatatt gaagcaaatt tgaagttttt acggacaaag gacatgacgg acatgtgcca 793921 gctgattgat gcagctgacc gcattttcgt ctacggttct ggaaatgcgc aaaagatatg 793981 cgcccgcgac ctgcaaagaa tgtttattcc gcgccatcgc tatcttattt tgattgaaga 794041 cacaaatgaa tttaatttga tgcgcgatga ttttaaagtg aacgatctgt ttatcatcat 794101 ttctctttcc ggagaaacac cggagctgat tcctcaggca agaatgcttt ctgcaaaggg 794161 tattcccttt atttccatta cgaatttaaa aaacaatgtc ctcgcccagc tgactccgca 794221 taatctttat gcgacaagca aacctgtgac attaagcgat agaacggaaa ttgtcgcttt 794281 tgcaccgttt tttctcgttg gcgaagcatt gttccgcgca tatgttgatt acaaagaggc 794341 agaaaaaaat gacaatgagt agcagggggt tctggtatga tgcaaaaaat tcagcgcttt 794401 ggaagcgcga tgtttgtgcc tgttttatta ttcgcgttcg ccggcattat cgtcggtatc 794461 agcacgctct ttaaaaataa aaccctcatg ggaccgctcg ccgatcctga cggtttttgg 794521 tatcagtgct ggtatatcat tgagcagggc ggctggactg tttttaacca aatgccgctc 794581 ttattcgcca ttggcatccc ggttgctttg gcgaagaaag ctcaggcacg cgcctgtttg 794641 gaagcgctta ctgtctacct gacattcaac tattttgtca gcgcgatatt gacggtatgg 794701 ggaggagcat ttggcgtcga catgaatcaa gaggtcggcg gaacgagcgg gttaacgatg 794761 attgcgggca taaaaacgct cgataccaac atcatcggag ccatctttat ttcttcgatt 794821 gtcgtctttt tgcataatcg ctattttgat aaaaaactgc ccgattttct cggcatcttt 794881 caaggctcaa catatatcgt gatgatttcc ttctttatta tgatcccaat tgcgttggct 794941 gtgtcttata tttggccgat ggttcaatcg ggaatcggct cgcttcaaag cttcctggtt 795001 gcttctgggg cggtgggcgt ttggatatac acgtttttgg aacggatttt aattccgacc 795061 ggccttcatc actttattta cacgccgttt atttatggcc cggctgtagc ggaaggcggg 795121 atcgtcacgt attgggcaca gcatctcggc gaatattcgc aaagcgccaa accgctgaag 795181 gagctctttc cgcaaggcgg attcgcgctt cacggcaact cgaaaatctt cggtattccg 795241 ggtatcgccc tggcttttta tgtgacagcc aaaaaggaaa agaaaaaact cgtcgcaggg 795301 ctgctgattc ctgtcacact gacagcgatt gtcgccggta ttacagagcc gattgagttt 795361 acgttcttat tcatttcacc tttcttattt gcggttcacg ccgtgcttgc cgccacaatg 795421 tcgacagtta tgtatatggc cggcgtcgtc ggaaatatgg gaggcggact gattgaggcg 795481 gtaaccttga actggattcc gctctttggc agccacggta tgacatatgt gtatcaaatt 795541 ttgatcgggc tctcgtttac agcaatttat tttttcgtct tcagattttt aatcctcaaa 795601 ttcaatatcg ctacaccagg acgggaaaag gatgaacagc aggaaacaaa gctatattcg 795661 aaaaaggaat acagagaacg aaaaaacaag gatgaaacgg cctccgctgc tgaaacggct 795721 gatgacaccg cttttctgta tattgaagcg ctgggcggaa aagacaacat cactgaagtc 795781 acaaactgcg ccacccgcct cagagtcagt gtcaaggatg aaacaaaggt tgaacccgac 795841 agcgtattcc gcgcgcttgg cgcacacggc gttgtcagga acgggaaggc gtttcaggta 795901 attatcggat taagcgtgcc gcagatgcgg gagcgtgtgg aaaaaatatt gaatcaataa 795961 agactgccct ccttttcggg agggttttcg tttgccgtca aaaagaccgc catagtaaag 796021 taaagaaaga gacaatcgag taaaaagggg tttggaggct tttacatgca aaaggctttg 796081 tcgtttttaa aaccatattc attgctggcg ggaattgctc tgattcttat gctgacggag 796141 cttgcagttg aactgatgca gcctttattg attgcaaaaa tcatcgacga tgggatattg 796201 aagcaagatc tgcggcatgt atggatatgg ggcacggtca tgatcgggct gaccgtgtta 796261 tcctttgcgg cggggatgct gaattccttt tatgccgccc atgtcagcca aagcttttcc 796321 tatgatacga gaaaagggct ttttcaaaaa atccagtcct tctcctattc cacatttgga 796381 cagttttcgt cctcttctta tattacaagg ctgacaaacg acgtcacaca ggttcaaaat 796441 atgattttta tgagtttgcg gtttatgctg cgggctccct taatgattgc aggcggcatt 796501 gtgctgtcgc ttgccgttaa tgtgaaactc gggttttttc tgcttgtgac cattccgatc 796561 ctgatcttgt ttttgctatg ggtattaagg aaaggcgggg cactgttccg ctcagtgcag 796621 aaaaggctgg atcaagtgaa caccatcatg caggaaaatt taattgcaat caagctgatc 796681 aaagcgctgc ttcgcggcag ccacgaagtc aaacgattta tcaaagccaa cacaaggctg 796741 atggaaaaaa cggtttcggc ctttcagctt gtggaattca cgatgcctgt actgatgctg 796801 ctgatgaatc tctgcatcct tttgattttg tgggcggggt cctacagtat tacgagcgga 796861 agcactcagg ttggcgatgt tgttgcgata attaactacg caacacgaat tacaggcgcg 796921 ctttcgatgt ttccgttttt gattatgatt ttcacccggg cgaaggcttc aggggataga 796981 atcggtgagg tgcttgaaac agaaggcgac gagcgggagg aaggcaccat atctgatcgt 797041 ttgtcaggac ggattgagtt tcagcatgta tcctttcgct atcctgaaat ggacagagaa 797101 gcgctcagga atgtctcatt ttccgcaaag ccaagagaaa cgatcgcgat tctcggtgcg 797161 acgggctcgg gcaagtccac gctttttcag ctcattccgc ggctttatca gccggattca 797221 ggccgcattt acatagatga aaagccggtt caagatattc cggctgaagg gctgcgcagg 797281 caaattggat atgtaccgca ggaagtcctc ttgttttccg gcacaatcaa agaaaacatc 797341 gcttggggca aagaaaatgc ttcactagat gaaataatgg atgcggcaaa acttgcgcaa 797401 attcatgaaa cgattttaaa gctcccaaat ggatatgaca ctgttttggg gcaaagaggc 797461 gtcaacctgt ccggcggcca aaagcagcgg atttccattg cgcgggcgct gattcgaaaa 797521 ccggctatcc ttctattaga tgacagcaca agcgcgcttg atctgcaaac ggaggcgaag 797581 ctgcttgaag caatcagcac ataccattgc acaactttga tcattacaca aaaaataacc 797641 acggcgatga aagctgatca gattttgctg cttgaggacg gcgaactgat tgaaaaaggc 797701 actcacagtg agctgctttc tgaatctcag ttatacaagc gcatttacga gtcacaattc 797761 ggaagggagg ggagcgagtc atgctaaaag acatccgcaa gcctttccaa tatcccaaac 797821 tgccaattga caaaaaagaa ggcgcgaaaa agcgggcgaa agcaaaggat acaaagggca 797881 cactgagacg aatctggtct tacttggctg aaagaaaagg actgctcata cttgtcatgc 797941 taatggttgt catcagcgcc atattcggac tccttggtcc ctttgtgatc ggaaaggcca 798001 tcgaccattt tatcgtcggg aaaacggtca gcggcttgat tcctgttttg cttcttctgc 798061 tcgctatcta tatcattcag tccctgtcgc tttggtttca aaactattgg atgattacga 798121 tctcgcaggg cacggttttc agaatgagaa gcgaattgtt cacccatctg catgagctgc 798181 cgattccatt ttttgataaa cagcggcacg gcgagctgat gagccgggtg acgaatgaca 798241 tcgaaaatgt cagttctacc ttaaacacgt cagtcattca aattttgtca agtgtgatca 798301 cctttgtcgg gacgattgcg gtgatgctgt acatgagccc gctccttact ttgattacgc 798361 tgaccattat tccggtgatg gcagcgagcc tgaaatggat caccaaccga acgggaaagc 798421 tgtttaaaga acagcagaaa aaccttggtg atctgaatgg gtatattgag gaatctgttt 798481 caggcgcaaa ggtcatcaaa gcatattcac gtgagaagca gattactgct gaattcctcg 798541 aaaaaaacgc tgcactcaag acgtcgggct tttgggcgca gacgatttcc gggtttattc 798601 cgaaggtcat gaactctttg aataacttaa gctttacaat gattgcggca atcggcggtt 798661 tgtttgcgct gaaaggctgg atctcgatcg gctccatcgt tgtctttgcc gagtattcaa 798721 gacaatttac acgcccttta aacgatctgg ccaaccagtt taatacgatg ctgtccgcaa 798781 tcgccggcgc tgaacgggtg tttgacgtgc ttgatgaaaa agaagagcgc gaggatgaaa 798841 agaacgccgt gcatcagccc atccaaacag gcagcattga attccgggat gtgtccttcg 798901 gttacgataa agggcagcag acactgaagc atttacagtt taccgtgcct gcggggcagt 798961 ccatcgcgtt tgtaggaccg acgggggcgg ggaagacaac cgtcactaac cttctcgccc 799021 gtttttacga gcctaacgat ggaaaaattt taatcgatgg tacagatatt aaaaccctta 799081 ctagagcaag cctaagaaaa aacatggggt ttgttcttca ggattctttc ttatttcagg 799141 gaacgatcag agaaaacatt cgctacggca ggcttgatgc ttctgatcag gaagtcgaag 799201 ccgctgcaaa aacagcgaat gcccatagtt ttattgaaag gctgccaaaa gggtatgaca 799261 ccgtactgac gcaaaacggt tcgggcatca gtcaagggca gaagcagttg atttctatag 799321 cgagggcggt gcttgccgat ccggttcttc tcattttgga tgaagcgaca agcaacattg 799381 ataccgttac agaagtcaac attcaagaag cgctcgcccg tttaatggaa ggaagaacaa 799441 gcgtcatcat tgcccacagg ctgaacacca ttcaaagagc ggaccagatt gtggtgctaa 799501 aaaacggtga aatgattgaa aaaggcagcc atgacgagct gattcggcaa aaaggatttt 799561 acagtgactt atatgaaagc caatttgaga aatagacctt tgtcctgcac agaggtcttt 799621 ttttgttaca gttttatagt acttttattt cattttcgta aaatgtaaca aaattacttg 799681 acgtaaacaa gttatgtata tatactagct tacattaagt aagtgataac atttatcaag 799741 gaggataaaa tgaataaatc atttgaaatt ggcacattac ttttaagagt tattacaggt 799801 attatctttt ttgttcacgg tttatcaaag tttcagggaa tggagggcac catccaattt 799861 ttcggcagca taggccttcc aagctttatg gcgtatgtca tcgcagcgat tgaactgatt 799921 ggcggagtgc ttgtcttctt cggattggct acacgtattg tcggtgtact gttcgctctt 799981 acactgatcg gcgccatcat cactgttaag ctgaaagcgc cattcatggg caatgcagaa 800041 tttgattacc ttctgctttt gacatccatt cacctggcgc ttactggaag tcgattcctg 800101 gcgctggacc catttgtgtt taaaggaaaa aagaacggaa acgtttcagc ataagaaaag 800161 aggcatgcag catgaccagc attcatgagg atacacacat tggctatgcc aaactcacaa 800221 ttcgcagtct ggagcgttcg cttcagttct actgtaacgt catcggtttt caagtcttaa 800281 aaaagacgga ccgccaagcg gaattaacgg ctgacgggaa acgcgtactg cttattcttg 800341 aagaaaatcc gagcgctgtc gtcttgcctg aacggtctgt gacaggcctt tatcactttg 800401 cgattcttct tccggacagg aaagaacttg ggatcgcgct cgcccgcctg attgaacacg 800461 gcattgctat cggacatgga gaccatgctg tcagcgaagc gctctacctg tctgatcctg 800521 acggaaacgg cattgaaatg tacgctgacc gcccccgcag cacgtggcag cgtgatcggg 800581 aaggaaacta cgtcatgacg acaaccgctg ttgacattga gggccttctg gaagaggcag 800641 gagatgagcg gaaaacatcg cttccgaacg atacaatcat cggacacatt catctgcatg 800701 tcagtgattt gaaagaagca aaggcgtttt atacagatgt actgggcttt gacattgtcg 800761 gaaactatgc gggcatgtcc gccctcttcg tttcagccgg ggggtaccac catcatatcg 800821 gcttaaacat ttgggcggga agaaatgcgc cgcctaaacc gacaaatgcc agcggactag 800881 attattatac tgttgtcctg ccccaccaag aggagctgga tttggtggca aaccgagtca 800941 aacatgccgg gtattcgatt gaagagacgg aaaacagctt tcgtgtgaaa gaccctgttt 801001 ccggcgccta tattacattt gtgatttaac tgcaatcccc ttgccgaaat aacggcaggg 801061 ggatttttta tttttgtccg ccttgttatg atgagagaac caacttgtta ggaggcgttt 801121 acatggaact caaccacctt gtgacgggca aaatagcatt aaatcaatat gtgcatcgct 801181 tagagcaaaa ggatgtttca ttttacgtcc actactgggg agcgatgacg aaccactata 801241 acacactgct tcataagcat tccttttatg aaatttgtta cgtggtaaga ggtgaaggat 801301 attaccttga aggcgatcgt acatatccgc ttcgtgaaca gacgattttt ttgtcaaagc 801361 cggagcattt gcaccaaatc aaaagtgaaa cagggctgtt ccttttttac gtcgctttcg 801421 agctgagcga ggatcagtca agcgccgaat ggatcaaagt gatggaagaa gtgaaacaaa 801481 gcccctttat cacaatgcaa ttgaaagatg gcgaaccgcc gggcctgctt tggaaaacgt 801541 taatgctgca agcagcgcaa cctgtcaatg cttttgacaa agagatccta tctcatttgt 801601 cgcatgcatt gatcctgtca ttaatccaaa cctttctccc gtacgcccaa cgcccgaaac 801661 aaaagcagcc cattcacaca tcttctgctt tgctgacaga ggtgaaactg cacataaaag 801721 acaatctgtc acagccgtta aagctgacgg atgtcgctag ccactttcat atctcaggga 801781 ggcatttatc acgtttattt gcagcagaac tgggcgtcag ctactcagaa tttgtccaaa 801841 atgaaaaaat aaacaaagct gccgaactgc tgaaatcaac gaatttgtcg attaaagaaa 801901 tagcggaaga aatcggtttc tcagtacatt atttcactcg cgtcttttcc gctaaaatcg 801961 gcagctctcc agggcttttc cgctcccttt ataaagactc aaaaatgacc gcatttcaaa 802021 tcaataaacc ttttcaaaaa atcgaacagg ccaagccgca cgaataagat gtcctgaaat 802081 gacaaaacaa tgtcttcata tgataaagac gcgagaaatc tcgttgtctt ataatctttt 802141 tagaaagcgg ttacaacaag gggtattgct gaaggaggga tgcattggct tatgcttggt 802201 gtcgggtgct ctgccattct tgaaagaagg ggaagaaagc cgtgagtaca aaaaagaaag 802261 aggctgtaat aggaaaagaa agcttagctc ataaagggct tttacgaacg attacattgg 802321 tatctacatt cggcggcctg ttgttcggtt atgatacggg tgtcattaat ggggcacttc 802381 cttttatggc aactgcaggt cagctgaatc ttacacctgt tacagaagga ctggttgcga 802441 gttccctgct tctcggggca gccttcgggg cgatgtttgg aggacgtctg tccgatcggc 802501 acggccgccg aaaaacgatc ctttatttag ccttactctt catcgcagcc acacttggct 802561 gtaccttttc accaaacgcg tccgtgatga ttgcctttcg ttttctgctt ggactggcgg 802621 ttggctgcgc ttctgtaacg gttccaacct ttttagcgga aatttcgccg gcagaacgca 802681 ggggacgaat cgtgacacaa aatgaactga tgatcgtaat tggccagctt ctggcataca 802741 cctttaacgc cattattggc agcacaatgg gggagagcgc aaatgtatgg cggtatatgc 802801 tggtcatcgc gacacttccg gctgttgtgt tatggttcgg aatgctcatc gtgcctgaaa 802861 gcccgcgctg gctggcagct aaaggcagaa tgggtgacgc cctgcgggtg cttcggcaaa 802921 tccgtgaaga cagtcaggca cagcaggaaa taaaagaaat caaacatgcg attgagggca 802981 cagcaaaaaa ggccggcttt catgattttc aagagccgtg gataaggcgc attctattca 803041 ttgggattgg aatcgccatc gtacagcaaa ttaccggtgt caattcgatt atgtactatg 803101 ggacagaaat tctgagagaa gccggttttc aaacagaagc tgcattaatc ggcaatattg 803161 caaacggtgt tatttcagtt attgcggtca tttttgggat atggcttctc ggcaaagtcc 803221 gtcgccggcc catgctgatc atcggacaga ttggcacgat gacagccctt ctgctgatcg 803281 ggattttatc cattgtcctt gaaggaacac ccgccctgcc gtatgttgtg ctgagtttga 803341 ccattttgtt tcttgcgttt cagcagactg ccatttctac ggtgacgtgg ctgatgctct 803401 cggaaatctt tcctatgcat gtgcgggggc ttggcatggg gatcagcacc ttctgcttgt 803461 ggacagctaa ctttctcatt ggattcacct ttcccatttt gctcaatcat attgggatgt 803521 cggcgacatt ttttatcttt gtcgctatga atatcctagc gattctattt gtgaaaaaat 803581 atgtgcctga gacaaaaggg cggtcacttg aacagcttga gcattccttt cgccagtatg 803641 gccgccgcgc tgatcaggaa atccaaaatc aaacaactca cttatcgtaa cctgagatac 803701 caggaggaat ctatcaatga aactatctta tgtaacagac agcctagggc atttgccttt 803761 tgaagacatg ctcaattttg ccgcaaagct tgggatcgat acacttgaaa tgacaaccgg 803821 gggctggtcg ccggcacctc acttgaatct tgatgaattg ctgcaaagca gcgaaaaaag 803881 aaaagaattt tcacaagcgc tggaaaagcg gaacatgaca ctttgcgcat taaactgctc 803941 ggggaaccct ttagatccgg gtgaattggg caaatcgcac agagacataa ctgacaaaac 804001 gatggagctg gctggattat taggcgtcaa aaaagtgatc atgatgagcg gtttgccagc 804061 cggcggcccg gacgacaaag tgccgaactg gatcacatac acagtaagct ggcctcccgt 804121 tttaaaagat atcctcaact atcaatggga agacgttgcg atcccatatt ggaagaagct 804181 tgtcaaaaaa gcggaggcct gcggcgtggg gaaaatagcg cttgagaact tcagctctca 804241 attagtctat aatcctgaga ctctctttcg gctcagaaat gcagtcggcc cgatggtcgg 804301 tttgaatctt gacccgagcc atttgttatg gatgggcgca gacccgatca tcgcagcaag 804361 ggagctcggc tcagccattc accatgtcca tgggaaagat gtcagaattg aaagatattt 804421 atcggcggtc aacggacttt tagaaacaaa agaagtgaca gatcctgcaa accgggcgtg 804481 gaattacgta gctgtcggct gtggacagga tttacagtgg tggaaggaat ttttttcagt 804541 tgtaaaaatg atgggatatg aaggtgaggt ttctttagaa atggaggatc tgacgatgtc 804601 acctgaagcg ggcatccgta cttctgtaga agctttaaaa caaaccatca gccaatagga 804661 ggttttcatg atgctaaatg gagaaagaat catctctaag ccgcttcgct gggcaatggt 804721 aggcggcggg cggctcagcc aggttggata taaacatcgt attggagcgc tgagagacaa 804781 tactgctttt caattaactg ctggcgcttt tgatatcgat gccgaaagag gaaaagattt 804841 cggggtgaac cttggagtgg atgcggaacg ctgttatccc aactatcaaa ccatgtttgc 804901 cgaggaagcg aaaagacagg atggcataga ggtagtatcg attgccactc cgaacggcac 804961 tcattatgag atttgtaagg cggcgcttga agcaggagtg catgtcatct gtgaaaaacc 805021 gctgttcttc acttcagcag aggggcagga aatcaaagcg ctcgcagaga aaaaagggaa 805081 aattgtcggc gtgacgtacg gtttttcagg caatcaaatg cttcttcaaa tgcgtgcgat 805141 gattgaacaa ggaatgatcg gcgatattcg cgtggttgac ttgcagtaca cacacggttt 805201 ttgtgcaaca gatgaaggtg aaaagataag cgctgcacag aaatggcgtg tcgaccctgc 805261 gatcgccggg ccaagctttg tgctgggcga tttatctacc cacacgtatt atatgtcaca 805321 gcttattatg ccaaagatga aaattaagga gctgctgtgt gaccgacaga gcttcgtcgg 805381 cagccgcgca ccgctagagg ataatgccca tgtgctgatg cattatgaaa atggagcggt 805441 cggaacgatg tggacatcgt caatcaatgc cggatgtatg gatggccata gaatccggat 805501 tgtcggctca aaggcaagca ttgagtggtg ggacagcaag ccaaatgaac tgacgtatga 805561 agtgcaggga gagccgggcc agacactcgt tcgcggcatg ccgtatttag atgatgtttg 805621 caacgccgat gaacgactgg gcgccttaca cagcgaaggg ctgtccgaag catgggccaa 805681 tatttatctt aaatttgcca ttgcgataga cgccaaaaac cgtgaagatg aagaaatctt 805741 gaacaacttg gtttatcctg acattgatgc agggatcgag ggcattcgct ggattgagaa 805801 ctgcgtgcgc tcggcaaacc aagggtcagt ttgggttgaa tttaaataaa tgagggaatg 805861 cgccgcatat gacataaagt tcatatgcgg tttttatttt ccagaaactc ctgtcaaaaa 805921 tgccctgagg caggtatgat aagaagggaa ttgggtatcg ggagtgatga gcgtgaaagc 805981 tctttttttt acgagaatgt tcaccttgat ggtgagctgt ttaatgtatc tgtccattgt 806041 gaaagaggat aactggtttg gatatgtatt tatagcagca ggtgctgcca tgtatgcagc 806101 caatcatgtt ttgctgacaa aagagacaaa tgccatctgg ttctgcctga ttgatattgc 806161 aatcggcttt tcgttcggat ttatctttcc cggcacaggt ttgttcatta ttatgctttg 806221 tccggttgcg gtcgcctttt ttctgcgggg gtttcctaaa agaacagcat ggtctgtctt 806281 atgtctttcc tctattttat ttttgaccgt cctcatccgt acatatgcga tgttcggcaa 806341 tgaatttgtc attgatcatt tgactagcat gacattcgtt gtcttctgcg gtgtcgtggg 806401 caaattaatc cgcaagctgt tggatgcgca ggatacggca aaacagcagt ttcaggaact 806461 gacggagtcc catctggcgc tgtctgctgc acatcaggag ctccatttat atgcgaagca 806521 ggttgaagag ctgactgcca tttacgagcg gaacagaatg gcgcgtgaaa tccatgatac 806581 agtggggcat aaaatgacgg cccttctcgt ccagctgcag cttttgcgtg aatggcaaaa 806641 aagagacagc caaaaagcgg atgagacagt aggtgtctgt gaaacacttg cccgtgaagc 806701 gcttgatgat gtccgcttat cagtacgcac tctgcaaact gaaaacgatc cttcgctaat 806761 cgaatcgctg aaacagctga cagaggactt ttgcaaaaat gcaggagtca caacagaatt 806821 tgcggtcagc ggtgatcctg caatcatccc gctgtctctc catccgaccc tgatcagaac 806881 ggtgcaggaa gcactgacca atgccaaacg gcacggcggc gccgcagcct gttcgataca 806941 gcttgcctgc acaacggaca gcatcagcct tgtcattaag gatgacggca aaggcaatcc 807001 tgaggcagca cttggttttg gtctcttgaa tatgaaaaag cgggcagcgg agcatggcgg 807061 aatgatccgc tttgaaagcg aacgggatca aggatttact gtaaatgcag aattttcact 807121 tgccaataaa aaatggagct tcgggcccgt gcagcaaaag gagagtttat catgattaag 807181 atcatcatta ccgacgatca ggatatcgtc agagaagggc tggcatccct gctccagctc 807241 cgagaagagc tcgatgtgat cgcaacggcg cgaaacggac aggaagcctt cgaaaaggcg 807301 aaagagctgg agccggatat cgtgttaatg gacatccgca tgccggtttc caacggggtg 807361 gagggaacaa aattaatcac aagctcgctg ccaagcgtaa aggttttgat gctgacaacc 807421 tttaaggatt cagcgctgat tgctgaagcg cttgaagagg gagcaagcgg gtatctgctg 807481 aaggatatgt ctgcagatac gattgtaaaa gcagtgatga ctgttcattc tggcggaatg 807541 gtgcttccgc cggaattgac tgcccaaatg ctgaatgaat ggaagcgtga aaaacagctg 807601 aaaggaataa atgagataga aaaacctaac gagctgctcg acctgaccga gcgcgaaatc 807661 gaagttctgg ctgagctggg atacgggctg aataacaaag aaattgccga aaagctttac 807721 attacagaag gcacagtcaa aaaccacgtt tcaaatatta tcagcaagct ggctgtcagg 807781 gacagaaccc aagccgccat ttactcggtc agatatggtg tatctgtctt ttgacatatg 807841 acgttttgca tatacgcttc tctgaaaagg ccttttacag gccttttttt catgccctat 807901 gttctatctg ccgctacatg ccgcacgcct ttctttcttc tacaatggca atggatcaaa 807961 aaaaggagtg agacgacgtg ctgcaagcag aaaacatcaa aaaggcatac ggaaaaaaaa 808021 caatcgtgaa aggcatttct ttttccctca aaaaggggga gtcgttcggt ctgctcgggc 808081 ctaacggtgc ggggaaatcc acaaccatct cgatgatttc cggccttgtg ccgcatgaca 808141 gcgggaacat cacggtgggc ggctatgtta tcggaaaaga aacggccaaa gcgaaacaaa 808201 aaatcggcat tgttccgcag gaaattgcat tatatccgac gctgacggct catgagaatc 808261 ttatgttttg ggggaaaatg tacggactta cgcacggtga ggccaaaaaa agagcggctg 808321 aggtccttga atatgtcggt ctgactgagc gggctaaaga taagattgaa acattttccg 808381 gggggatgaa acgaagaatc aacatcggtg cggctttaat gcataagccc gagctgctga 808441 ttatggatga accgactgtc ggtattgacc ctcaatcgag aaatcacatt ttagaaacgg 808501 tcaaacagct caacgaaacg ggcatgacgg tgatctatac gagtcattac atggaagaag 808561 ttgagttttt atgcgaccgg atcgggataa ttgatcaggg ggaaatgatt gcgattggca 808621 caaaaactga tttgtgcagc cgccttgggg gcgataccat cattcagctc acggtcagcg 808681 ggatcaatga agcgtttctt gtggcgatcc gatctctggc ccatgtgaat gatgtaacag 808741 tacatgaatt agagctcaaa attgacattt ctgcggctca tcatgagaaa gtcgtcacaa 808801 gcctgcttgc tgaagccact gctcatcata taaacctgct gtctcttcag gtgcaggaac 808861 cgaatctgga gcgcctgttt ctgaatctga ccggccgcac gttgcgggat tgaggaggga 808921 cggcaatgaa aaaaagcata tggatcgcat ggaaagatgt gaaaatcaga atcacggaca 808981 gaaaagggtt tatgatgctt atcctaatgc cgctcatcct aacctgtatt ttaggcgcag 809041 cgctcggatc agttgttgac ggaggcagcc ggattgatga tatcaaagtc ggctacattc 809101 aatcagacca gtcagataca gcaaacatgt ttacaaaaga tgttctcaaa aaaatgaagt 809161 cgataaaggt cacaaaagtc ggcagcaaag acaagatgaa aaaactgatt gatgaaaaga 809221 aaatcgatgt aggcatcgtt atcccgaacc attgggaagc cggcaaaacc tcagctgttg 809281 ttaatgccgc tcctgatcaa acattgaaaa gttccatcat tgaaacagct gcaagctcat 809341 ttatagagca atataaagcg gtaaaggaag ccgcgtcagg ctcaatggac tacatcagta 809401 aaacggaagc tgtaaagcaa ggaaaacttg accctgcaca gtttgcagaa aagctggcaa 809461 agacgctaga aaaagaaaca ggtgacaagc ttactattgc ggaaaaatct gtcggcagca 809521 aagccgttac cagttttcaa tactattcgg cggcaatgct ttgcatgttt atgctgtttc 809581 atatcacagt cggggcgaaa tcatttttac aggaaaagga tacggagacg cttgccagaa 809641 tgctgatgac gcctgcgcaa aaatccgtca ttctcttcgg aaaatggctt gggacgtatc 809701 tgtttgccat catacaattt ttcatatttc tgatcgtcac aatcaacgta tttggtgtgg 809761 actggggcgg taatctgctg ttagtgagtg tactcgggct ttcttacgcc gcagctgtat 809821 ctggtatttc aatgctgctt gcgtcgtgca tcagcgatat gaaaactgca gatgcgatag 809881 gcggcttcgg cattcaattg cttgcggttc tcggcgggtc catgctgccg ctgtaccaat 809941 ttccggacgt cttgcagtct gtatccaaag cggtgccaaa tcgctgggcg cttgacggct 810001 ttctttcttt aatggaaggg ggaggctggg ctgaccttca aaagcctgtg cttctttttg 810061 cggcgatcgg cttttgttca cttgtaattg gtatcagacg gcttcataca agataaggag 810121 gtacaaaagg tgaaaaaaat tctagccatt tgcggcattg agctttctct catttttaag 810181 aagccacaga actatttgat catgtttgct gccccgcttt tgcttacctt tgtatttggg 810241 agtatgctca gcggcaatga tgataaggtg cggcttgcaa tcgttgatca ggacgatacg 810301 attctctcac agcattatat tcggcagctg aaggcacacg atgatatgta tgtattcgaa 810361 aacatgtctg aaagcaaagc gtcagaaaag ctgaaacaaa agaaaattgc cgggatcatc 810421 gtcatttccc gctcgttcca gacacagctg gaaaaaggca aacatcctga gctgattttc 810481 cgtcacggcc ctgagctgtc ggaagcgccg atggtcaaac aatatgcaga aagcgcattg 810541 gcaacgctca atattcaggt gaccgcggca aaaacggcat ctcagacagc gggagagaac 810601 tggaaggcgg cgtataaaac ggttttcgcc aaaaaacatg aagatatagt tccggctgta 810661 acacgacaga cgctcagtga taaaaaagag ggtgcggaag caagtgacac agcctccaga 810721 gcagcagggt tttccatcct gtttgtcatg ctgaccatga tgggagcggc tggaaccatt 810781 ttagaagcaa gaaaaaacgg cgtatggtcc agattgctta cagcctctgt cagccgagcc 810841 gaaatcggtg ctgggtatgt gctgtccttc tttgtcattg gctggattca atttggaata 810901 ttgcttcttt ccacccattg gctgtttggc atcaactggg ggaatccggc tgcagttatt 810961 gtattagtgt cactttttct attgaccgtt gtcggcattg gattgatgat tgcggccaac 811021 gtcagaacgc cagaacagca gcttgcgttc ggcaacttgt ttgtcatcgc aacatgtatg 811081 gtgagcggga tgtattggcc gatcgacatt gaaccgaaat ttatgcaatc catcgctgaa 811141 tttcttccgc aaaagtgggc gatgagcggg ttgacagaga ttatcgctaa cggtgcccgc 811201 gtcacagata ttctcggaat ctgcggcatt ttgcttgcat ttgctgcgat cactttcgca 811261 gcggggctga aagcgctccg agcctaaaaa acatctgccg tttaggcaga tgtttttttg 811321 catgtgggta cattcgtatg ggtgcagcct gaactgcggt taatccttat ctatcatagc 811381 taaaattgat tccagccaag aaacgtaatt tttctcccgc tccagcgctt tcgttagcac 811441 aagatagtgg ccgaagtccg gtgaagaaaa tgacatcggc tctgctgaag ccataagctt 811501 ttcatagctt ccctgtaagt cagaaagctt ggcctggcgt ttttgcagct ggtctttgaa 811561 caaatcagaa gcctcctggc gcgatagaca agaaatgaaa taagccttca gcataaattc 811621 atccttcacc gtctcgggta tcggctggtg gcggatcagc cagtcatgca gctcctgctt 811681 tccgctgtct gtcagggtgt acatcttttt ctccagcttt gtgccctgaa tcgttgtccg 811741 gaacgtgata aatccttcat ccgtcagctt tttgagctca gggtaaatct ggctgtgctt 811801 ggcgctccaa aactggccga gctcctcttt aaaataactc gtaatatcgt atccactcaa 811861 ttcgcctttt cgcaaaagcc ctaatatggc gtattttaat actctcatgc tatcctccgt 811921 gtctggctgt ttcgcaaaac agatgagccg gtgctcaact gtgattctaa ctgcctattc 811981 cccttattat agaaaaggga ggaagggaac acaaccgggc tctttggaaa tgaagataaa 812041 aggtttgtca gaaggtatcc gatttatctc cgtcaatata aaagagattt aaatttaatt 812101 ttcagaaaaa atagtaacga tattgatttt ttatatataa taggaaattg gtggtatgaa 812161 aattttttgg gggaataaac gtgaaaaaag tacttatggc attcattatt tgtttatcgc 812221 tgattctatc tgttttagcc gctccgccgt ctggcgcaaa agctgagtca gtacataatc 812281 ctgtcgttct tgttcatgga ataagtggtg catcatacaa ctttttcgct attaaaaact 812341 acttaatttc tcaaggctgg caaagcaaca aactgtacgc aattgatttt tatgataaaa 812401 caggaaacaa cctaaataac ggcccgcagc ttgcttcata tgttgaccgt gttttaaaag 812461 agactggggc aaaaaaagta gatattgtgg ctcatagtat gggaggcgcc aatacgctgt 812521 actatattaa atatttaggc gggggcaata agattcaaaa tgtcgtaacg cttggagggg 812581 ctaatggttt agtgtcatca accgcgctgc cgggcacaga ccctaatcaa aagatcctct 812641 atacatctat ttacagtctc aatgatcaaa ttgtcatcaa tagcttgtct cggttacaag 812701 gagcgcgaaa catccagctt tatggcatcg gtcatattgg cttgctttct aatagccaag 812761 tgaacggcta tatcaaagaa gggctgaatg gcggaggcct caatacaaat taatatcttc 812821 aaaaaacaac ctgctgtctc cgttacagtg ggttttttcg tctgagaaag ccatagggtc 812881 ttatgacctt agtctatcat gcatacgtca atttatgaca tcaggcactt tttcaaatag 812941 agcggacatg ttaaggtaca accatcgatt tctatcaatt tgaaataaaa ggagcgctgt 813001 tatgcaaatt aaagaaattt ttatgatccg ctgcatttcg tgcttaagtg tcgtcttgct 813061 ccatatcatt tcaatggtcc tgatgcttca ggcagaagct cttgcagata tttctcacac 813121 tgttgattct ttccgcacac tcctgatgtt cagcacgccc gcttttattt tcatctctga 813181 atttttactg gcccgttctt atcctgatgg ggtgcctgac ggttttttaa agaagcgggg 813241 aaaagtgatt tttgttcctt ttttatttat cgcagccatc gatgcgctgc tgatgaccag 813301 tgcgatgggg ggagaggtaa cctttctcgc gtttgtgcaa aaatatctgg cgaacgtatt 813361 cttaggaaac tttatcggat acttcattct cgtcatcttt caattttaca tgctgcatat 813421 gatgtttcat gagtatttga aaaaagcatc gccgaaatgg gtgctgtcta tctcatttgt 813481 ggtgacagcc gcttatttag gctatttctc cgcagccagc ccggctcctg cttctgaaga 813541 gggaggggca tttccgttct tctgggttcc gttcgcaggc tggcttttct acttttgtct 813601 agcctactat tgcggaaaag aatacaagcg ttttttagcg ctgctgaacc aataccgctg 813661 ggtggtgtac ggcgccgcaa ttgcttctgg ggcgctggtt gtcactgttt cttatgtcgg 813721 tgaaatcggc atgatcagct cgaagcggcc tgatatcatg ctgtattcaa caagcatgat 813781 tttcctgtgt tttcatttgt tttccaaaat gaagcatgtg ccgaaaatca tgatgtttat 813841 cagcaactat tccttttcga tttatctgct tcatgcctat tttatgatta taggctacgt 813901 gttgcttttg aatatgcccg aaattcctgc cgtaccggct gttctcctgt tgtttgccgt 813961 gtgcacagcc ggcccgatta tgacctcatg ggcgctgaat aagttcaaat acgggtattt 814021 atttgtgggg aaaatttatc agccaaaaca gaagaaggta acagtcgaag tgcgtgatca 814081 cgcagggtga aaaacaagcg gcaggagggc tcctgccgcg tttctttact tctcatccgc 814141 ttgcagaact gtttttaaat atagttttgc agactcagca agtccagata catcagcctt 814201 ttcttcatcg aaatacaggg cgttttgaat gatgccgtca ttcatattga ggaaaaactt 814261 ggcgatagtc gcaagaggct gaaccggctg aaactctccc tgatcgatcc ctttttgcaa 814321 tagccttgaa aacctttcca caaaaagatc ataccttttc tccaaatact gccgccgttc 814381 ttcattgcgc caagctgtca ctaaatattc aaattgcacc ggcgccagcg tatctgctac 814441 atctcgcagg ccctcagtca gttcatccaa atagctggaa atggaggccc aaacactttg 814501 gtgttcagct gatttatcaa gctttcggag tccttcatcc agccctgttt caataatgcg 814561 gcgaaacatc tcctcagtgc ttgaaaaata aagatagaca ccgccccggc tgaaacctga 814621 ctcttctaca acatccttca tcgtcgttaa ttcgaatcct tttcgtttaa aaaccgtttt 814681 ggcagcctct aaaatctctg cctgccgttt atccttgtgc tcctttgtta cttttggtga 814741 caagatatcg cctgctttct gcaattttct tacctataag tgtaatcaac ccaatcatga 814801 tcagcaagca gccacagaca agaaaagcaa gtgatacacc gatccattcc gccagcacgc 814861 ccccgcccgc catgccgagg atagaggcga gggttgtcgc actctgaata gcgccgaaca 814921 ccctaccgct gtaatcgaca ggcactgttg tttgcacgag aatctgaaat ggaatatgga 814981 cgaggccgaa agccgccccc atgatgaaaa aagcaaatat aaagagagtg atgccggcaa 815041 ttcccatacc gcttaggaat ggcgcacctc cagttgctag tccaagaaga agggttccag 815101 ctgagaaata aagcaaataa gaagtgattc gccgtctgcc ggtaatggcc gctgtaagga 815161 gcatcccggc tccgcttacg gccatgcacc agcctgccag ctcgggcgga gctcctgaaa 815221 aggagcggat aagaataatc gcttgggaat caccaatctg caaaacaaag agaacgacac 815281 aagctgttag taagcctgtt aatagaagcg gcatccgttt caaaaactga aggccttcct 815341 tgatagaagt aagtgctgct gttttttctt gaggtgtatt ggctttttgt aaaaaagcat 815401 ctctgggaag gaaaaacaaa atgacagcgg aaagaaagaa ggcgccggcg tttatataaa 815461 aaacagagtg tatcgagaaa gcagcgatca gcgtgccgcc aagggcaggg ccgaagattt 815521 ttgagctgtt atcaatgatg ctgctgacgg aaacggcctg ctgaatgtgt gcttccggag 815581 ccaattcctt aagctttccg tttttagcag gtaaaaaaag tgaagaaaaa cagctctgaa 815641 cggatagcaa tacgtaaagc tgccaaagct cactgacata aacgcagctg ataacagtga 815701 gggcacggcc gatttcagat agaaacatga tcgtttttct gtcaaaacgg tcggcaagca 815761 gacccgatac aggtccgagt acaatgacag gcaaagcaaa cgacatcatt aaaagcgaca 815821 tatctaatgg agaagcatga agctgaaaag cggctaatgt tagcacggcc aaaatgtgaa 815881 gccagtctcc aagtgaagaa atggtttgcg aggctaacag tgtcatcagt cctttttgat 815941 tgcgaaacaa cggtttttcc atgattcatc ctcctgatta ttaaaatgac actagtgtcg 816001 tttttaattg tatgggaaaa agacacaata tacaatcttt ttcttgtaaa ataaaggaga 816061 agattgaata gaagggagaa cattcatgac atcagtcaat ctaagctacc caataggaga 816121 atacaagccg agggaatcca tatcgaagga gcaaaaagat aaatggattc aagtacttga 816181 agaagtgccg gcaaaattga agcaagctgt agaggtcatg acggacagcc agcttgacac 816241 accgtaccgg gacggtggat ggaccgttcg gcaagttgtt catcatctgg ctgacagtca 816301 tatgaacagc tatattcgtt ttaaattgag cttgacggaa gagacaccgg ctatccgtcc 816361 gtatgatgaa aaagcatggt cggagctaaa agactcgaaa acggcagatc cgagcggctc 816421 actcgcgctt ttgcaggagc ttcacggaag atggacggct ctgctccgca ccctgacgga 816481 tcagcaattt aagcgcggat tttatcaccc tgatacaaag gagatcatta ccctggagaa 816541 cgcgctcggc ctgtatgtct ggcactcaca tcaccatatc gctcatatta cggagctttc 816601 cagacggatg gggtggtctt aacgcttttg ccggcggaaa gccggaatac tgatagcagc 816661 aatcaccaga agtgagacca cagcagccgc tgcatataaa tgatcatagc cgctggcgac 816721 actcgcatga atggcgtcgc ttatcgcggt tttgacttca ggaacgggaa tgcgttcgat 816781 ttgttcttgt aaagaagaaa cttcagaact gtcgatctcc ggaatcatct gcatcgcctt 816841 ttctgaatat ccgctgtccg ataagcggct gttgatctca tcacctattt ggtcaaaccc 816901 ggctgtgata aaacctgcat aaagagtagg cgccaaggtc agtccaattt gccttactaa 816961 tgaaagcgtg ccaagagctg tacccttatt tgtttttgcc gcttctgata caaggacgtt 817021 cagcggagcg cctaacagaa agccaaaacc gatcccagct gccacacttg cgatcacaaa 817081 ctcccatttt tccgtgaccc agagcggaaa taaagcaaac cccgcacatg agatgattcc 817141 cgaaagaata acggttttta caggaccttt tttgtcggta agtgctccgc caagccaagc 817201 gccgattccg gaagccaacg caagcggtgt catccaatag cctgcttttg cggcagggac 817261 acccaaatac tgttcgacat atgacgggat aaaaatgact gccgccaaga gccccccgga 817321 taacaaaccg atgataagcg tgcgctgaaa catatggttt cgcagcagag aatacgccaa 817381 aatgggatcg cctcctcgca tttcaactct cttttcatac gagataagcg ctgcaaaaca 817441 gagtatgcca aaaataatac atccataaac ctccggattc cccaagctgt gtaagagatt 817501 tgccccgtca agattggtca tgccgtacat cacagctaaa atcgacaggg acaaaaggaa 817561 gattccggcc gcatcgaggc gcttagcctc aggtgctttt gtttccgcga taaaacatgc 817621 gccgaaaaca accaatagca cggcaatcgg caaattaatc aaaaatagcc aatgccaaga 817681 cccggtccaa tcaagcagaa agcttccgat atttggcccg agcacagcgg ccatcccgtt 817741 cattgcgcca agcagcccaa gcgccttccc ctgtttttcc tttggaaggg tcgcgagaat 817801 gtgagagctg ccgatgatga aaatcccgcc gcctccaagc gcctgaatca gccgcgatat 817861 cagaaagagc gggaagcttt ggctcaaagc aacaagcaaa gaaccaagtc cgaacaggca 817921 aacctcaatg agaaagagtt tttttctgcc gtagcggtcg gaaagttttc cgacgattgg 817981 cacactgacg ctaagaccga gcgtataaag ggtaatgccc catgatcccc aggaagggga 818041 aacggaaaac gactcgttta tcgttgttaa agcagccgaa ataattccgt tatctaaagc 818101 agccataaac acgccaatcg taaacaggct gattgcccac ttttggcttt tctgctctgt 818161 taatgcttca gacattttcg tcaactcctt ttagttcact tgaaatatat tattcatttt 818221 aaatgaacta aatgtcaaat aaaaaaagcc tgctcccgca gtttgcggat gacagactta 818281 ctgatttatt cttttttcgc attctctaat gctcttgaaa ggatagacag cccttcgtaa 818341 acagcctgct tttcttcagg ggacagcagc tctaatgaac gcttcaattt caggtggccc 818401 ttttcataca aaccccggaa aatctttttc gcattctctg tcaactgaac aactacagag 818461 cggcggtcct cttcagaatg tgagcgtttg acaaatcctg atttttcaag ccggtcaagc 818521 agcccagttg tattggacag ggaagccccc attttttcag caatgtcgct cactttcaat 818581 gttccatggt tgtttaatag catcagcacc ttcatttgcg gcatgctcat atccagtttc 818641 atccactcgg acacatcacc gagcccggcg gacgttaaga ctttcatata gagcacccat 818701 atttcccgtt cctccgatga aagaatgttt tcgtttaaga ctgttgtatc gtgtaaatta 818761 tattccattt catcacttcc tcatcattca ctcctcttac catattactc gattttcact 818821 cctgaaagaa agtgagcaga aaccgcatgc gggactttgt ccgaaaaata acggtagtgt 818881 ataatgagtt ggagattatt gggggagagg atcgaactag aatatgattg gagagaccat 818941 tgctgattaa aaagaatgct ttatcaatat taaaaatcgt ttttcctatt gctgttttgc 819001 tatttgttat ttatcaatcg aaaaaagaac tgacaaatct gtcattcaaa cgtacgctca 819061 tggtcatcaa cggactggaa cgaacggatt tattcatgct tgtgttgatc ggcttgctgg 819121 ctgttgcggc tatgtcgctg tatgattacg tcctgaagta ctcactgcgc ctatcgatca 819181 caaacggaaa agttttcagg gtttcctgga tcgccaattc atttaataat gtgttgggat 819241 tcggcggttt agccggagtc gggttaagaa tgatgttcta taaggagcat acgaaagacc 819301 ataaggcact cgtgaaagga atcgcctggc tcacatcatc tatgctgctc ggattatctg 819361 ttttcagcat tttcgttgct gcgagagtgc tgccagttga tgaagtgatt catgagaagc 819421 cttggctgtg ggcggtcgtt atcggttttg cactgatatt gccgttatct ttagcggtgt 819481 ccaaaataaa agaccgcaaa gctggggacg aagagaatgc ggataaagtg aaaaatccga 819541 ttttcgcata tattggagct tcagttgttg aatggctcat ggccgggacc gtcatctatt 819601 ttgctttgtt cgctatgggc attcatgcag atatcaggta tgtgttcggg gtgttcgtca 819661 ttgcggcgat cggaggaatg atcagcctcg tgccgggcgg cttcggctcg tttgaccttt 819721 tatttttgct ggggatggag cagcttggct atcatcaaga ggccatcgtt acttctattg 819781 tgttgtacag gctcgcctac tcatttatcc catttatctt gggactgttc tttgccgccg 819841 gcgacctgac ggaaaataca atgaagcggc tcgaaacgaa cccgcgcatc gcaccggcaa 819901 ttgagacgac aaacgttctg cttgttgttc agcgtgcggt attagtgaga attttgcaag 819961 gctcgctttc ccttattgtg ttcgtagcag gtctgattgt cttggcctca gtttccttgc 820021 cgattgacag gctgacggtt ataccgcaca ttccgcgccc ggcgcttttg ctgttcaacg 820081 gcctgtcctt aagctcagcg ctcattctgc tcattttgcc gatcgagctt tataaacgga 820141 caaaacgttc ctacacgatg gccattacag cgcttgtcgg cggctttgtg ttcagctttt 820201 taaaagggct taacatcagc gcgatattcg tactgccgat gattatcgta ttgcttgtgc 820261 tattgaaaaa acaatttgtc cgcgaacagg catcctatac actgggacaa ttgatattcg 820321 ctgtggcgct gtttactgtg gcgctcttta actacaatct gatcgcgggc tttatttggg 820381 accggatgaa gaaggtgctg cgtcacgaat atttcgtcca cagcacctcg catattacac 820441 atgcaaccat catggcgatc atcattgtgc cgctgttctt cttgatattt acagtggtct 820501 atcataagag aacgaaaccg atcggagaga aagctgaccc tgagcgtctt gctgcgtttc 820561 tcaatgaaaa aggcggcaac gcgctgagcc atcttggttt tcttggagat aagcggtttt 820621 atttttctag cgatggaaat gcactgcttc tgtttgggaa aatcgccaga aggctggtcg 820681 tgctcggcga tccatctggc caaagagaat cattcccgct cgtgctggaa gaatttctga 820741 acgaagcgca tcagaaggga ttcagtgttt tgttctatca aattgaacga gaggacatgg 820801 cgctgtatca cgattttggc tacaacttct ttaaattggg tgaggaagca tatgtagatt 820861 taaatacatt taccttgact gggaagaaaa aagccggcct tcgggcaatc aataaccgct 820921 ttgagcggga ggagtatact ttccatgtgg atcatccccc attttctgat gcgtttttgg 820981 aggagctgaa gcaaatctca gacgaatggc tcggctcgaa aaaagagaag ggattctcgc 821041 tcggattttt tgatccttcc tatttacaga aagcgccgat cgcctatatg aaaaatgcag 821101 aaggagagat cgttgcattc gcaaatgtca tgccgatgta ccaggaagga gagatatcgg 821161 tcgatctgat gcgctatcgc ggcgacgctc caaatggcat tatggacgca ttgtttatcc 821221 gtatgttttt atgggcaaag gaagagggct gtacgtcatt taatatgggg atggcaccct 821281 tggccaatgt cggcactgcc tttacatcct tctggtccga aaggtttgcc gctgtcattt 821341 ttaataatgt cagatacatg tacagtttca gcggcctaag agcctttaaa gaaaaatata 821401 aaccggagtg gcgagggaaa tacttagcgt atcggaaaaa cagatctctt tctgtcacca 821461 tgttcctcgt tacacgtctg attggcaaaa gcaaaaaaga ctccgtctaa taagacggag 821521 tcttttttta tttcgttttt aagaagtagg tttcaatatc atcaagcagg tagtttgcgg 821581 ctttaattcc gcctgcggtt gtccatacga cgtcatcgac ttcatgtgca ttacctgact 821641 tcacggcctt caggtttttc catagtgaac tgcttgtcca ctgattggcc catttttcat 821701 tttcttttgc attatcggct ttataagtga aataaaacag cacatcagca tccatatcag 821761 gaatagattc tttactgtcg gttgagaacg taaattggtc cttttgtttc ttaaacagtt 821821 ccacttgttt ttcagggcgt ttgaagccaa gctggtctaa aataatccca ggaaatgaat 821881 cggtataata gattcttgat tcaccggata aaaagcgtac gactgaaacg gttttgtttg 821941 tctggtcgcc cagcttgttt tttaaatcag aaacacgttt atcaaaatcg gcaatgactt 822001 ccttgccttt gtccgcctta ttcaccgcgt tggcgtatag agtcaggtta tccttccagt 822061 tcccggccaa agattcagca aaaacagtcg gcgcaatcgc atttaactga tcataaattt 822121 tttcctggcg cactttgttt ccaataatca aatcaggctt taattctgcg atggcttcca 822181 cattcggttc cgtttcaaga ccgacgtttt taacaccttt catgtcatct ttcagatagt 822241 cataccacgg gtcgcccttc catgacttta cggctccgac cggcttaatg ccaagcgcta 822301 agagcgcctc tgttccttca ttagttaaaa caacaatccg ttttggattg gcggggatgt 822361 tgtctgatgt ccccattgca tgtttgaccg ttcttgtttt gctgcttgac acctcgctgt 822421 tgcttgaact ttctgaacta ttacaggcag aaagtaccat aacggccatt aaaaatacga 822481 atagcatgct gatatgcttt ttcatctttt tcctcccaat attgaaattc attatcattt 822541 agatcataat aagcagtgtt aagagtgtca atccctaatt gaggattatt ctcaaaaaca 822601 aacattacat agtaaataac taggagaatt agatcatgat ctgcaaaaag gcatcttcaa 822661 aatggattgt gttagtatgt ctgattttca ttttactgac ggctgtctgc gcaagcgtcg 822721 tgtatggcta tacaggtacg tcatggagac aggtctatca ggcgtttact tccttcaatg 822781 gaacaaatga gcatgtcatc atcaaggatg tcaggcttcc gcgcgctttg gttgcgacag 822841 tcgtcggcgc ctcgcttgca gccgcgggcg ctctcatgca ggcgctcaca aaaaatccgc 822901 ttgcgtcacc ggggattttc gggattaacg ccggtgcagg tttttttatt gttgccggat 822961 cgttttttct gcatattcag tcacctcagg cattagtatg gagctcgttt ctgggggcag 823021 catttaccgc tgcgatcgtc tatgcagcag gctcgcttgg gagggaaggg ctgacgccaa 823081 tcaaactgac gctggcggga gctgccatgg cagccatgtt ttcttctctg acacagggct 823141 tgctgtctgt caacgaactc gagcttgccc aggtgctttt ttggctgact ggctctgtgc 823201 agggccggag tctggatctg ttgatgacga tgtttccata tgcagcggca gcgctggtaa 823261 tctgcttctt tctcggccaa aaaattaatc tcctcgttat gggagaagat gtggcaaaag 823321 gactcggcca aaaaacaggc ctgctgaaat ttgtgatggc gctttgtgtt gtcatgcttg 823381 cagggtccgc tgtcgccatt gccgggccga tttcttttat cggcatcatt attccgcatt 823441 ttgcccgctt tgtcgttggt aatgattatc gctgggttct gccattttcc gctgttttgg 823501 gtgccatttt gcttgtttgc gcggatatcg gtgcgcgata tatcattatg cctcaggaag 823561 ttcctgtcgg ggtcatgacc gccatcatcg gaatgcctgt gtttgtgtac atcgcaagaa 823621 ggggggcgaa gctatgaaac ttcgttttgg cgttactgcg gctgaaaaga aagcatggat 823681 cgtctttttg gttttactgg ggttaacagc tgctgtactc atcataagcg ctggtctcgg 823741 acaaaggttt attcctccct gggatgtagc aaaaacattc tttggtgcag gttccaagct 823801 ggatgaactg atgatcatgt cgttccgcat gccaagaatt ttgacggctt tatgcgccgg 823861 tgtctgcttg gcagcggcag gcgcgatatt gcaggggctc gtcagaaacc ctctcgcatc 823921 tccggatatt atcggaataa caggaggagc ggcggtagcg gtcgtgcttt taatgatgtt 823981 cttctcagac cgcagcagtt cacttacgat cagtctgtca tggcttccag cagccgcatt 824041 tatcggcgca tcggctgtcg ggctcatcgt ctatttactg gcatacaaaa atggcgcctc 824101 cacatttcgg ctggtgctta tcggaatcgg attttcaatg tcggcgcagg cgatgactac 824161 cctgttgatg atcaaaggcc cgatttaccg agcatcacaa gccaatgtgt atatcactgg 824221 gtcagtttat gggtcaaact ggcagcatgt aaaaatagct attatcttat ctgtcattct 824281 cttattcatt tgttttgtcg cgctaaaaaa tatgaatata caggtgctgg gtgaagatat 824341 tgcggcgggt gcaggaagcg ctgtgcagcg aaatcgtttt ttcttgctcc ttttgagtac 824401 ggctcttact ggttgtgcag tttcagttgc cggcacaatc ggttttgtcg ggctgatggc 824461 gccccatatt gcaagacggc ttgtcggctc atcttatggc gcgctgctcc cagcgtcggc 824521 acttattgga gctctgctcg ttttaacagc tgatatcgtc ggcagaacct tatttgctcc 824581 ggtggaagtg ccggccggcg tctttacagc ggctatcggc gcaccttatt ttatttattt 824641 gctctataaa acaagaaatt cttaatcgtt acacccattt tcttaaaaaa gaaaatgggt 824701 ttttttgata atgactgaag attcgtaatt atttttgcta tactgacaga gacattgata 824761 aagaaagggc ggcagatgaa tgaaagaagc agaggtatta aaatatgaag catttacaag 824821 cagtcccggc aaaggaaacc ccgcaggcgt cgttttgcag ggagacgatt atacggaaga 824881 cgagatgcag atcatagctg aacgtgccgg gtattcagaa acctccttta tccgaaaaag 824941 cgagtcggcc gatcttgaac tccgttactt tacccctgga cacgaaatga atttgtgcgg 825001 tcatgcgaca gttgcttctc tttacgcatt atgtgagaaa ggaatgctgg agagcggtaa 825061 aacgtacagc atccaaacga aagcgggtat cctgcctgtg aagatttctg aaaaagatgg 825121 ccgcattcat atcacgcttg aacaggcctc tccgcaattc aaaccattta caggcgatcg 825181 gaaaaaactt gcggacgcac tgggtatcac cgatgaagat tttcatgaag accttccgat 825241 tgtgtttggc agcactggga tatggacagc catcgttccg cttaaatcat tggaggcttc 825301 caaaaaaatg gtgccagata acaaacaatt tccggaagtg ttagttgatc tgccaaaagc 825361 ttcagtccat ccgtttacct ttgaaaccgt ccatcccgac agcgacctgc acgggcgcca 825421 cttttcatcc ccgtattcgg gaacgattga agaccccgtg accggcacag catccggcgt 825481 gatgggggct tatatgaaac attatggcaa tgccgagcag cataaattta tcattgaaca 825541 agggcaggaa attggaaaag acggaaaagt ggagatcgaa atgaacgaag ccggcggcca 825601 tgtgaaagtg aacatgacag gaacagccgt ttactcagaa acccgtattc ttaaaatcta 825661 atacggatga tggtttacaa aaagatgcac tttccgttat cattatgaaa tgataatcat 825721 tttcaattgc ataggaaggt gagacggtat gcctcaaacc gaacaaatac atcagcattc 825781 agtactgagg gacatcatac gcagcagaag atcgattcga aagtttaaac aagagccagt 825841 accttcagca gtcattcttg acatgcttga aacggcaaaa tatgcgccaa atcacagagt 825901 gacagagcca tggagattta tttacgtttc cagtgagaca ggtaaagcga acctcattaa 825961 tacatttgca gcgttctcta agaaatccaa gccggatatg acagaggaaa agcttcaaaa 826021 tttcaaaaac acacttgggc gcgttccggg atttctcctc gtcgtgtttc aggaagatga 826081 aaacgaaaga gcgcgggacg acgattttgc ggcaacaagc tcgttgattc aaaatcttca 826141 gcttctcgct tgggaaaaag gaatcggcat ggtttggaaa agcggaaaaa tcctttatga 826201 caaagaagtc catcaggcct ttggtttaca ggataatgag cgtttcgccg ccatcataca 826261 aacaggttat cctgacgagg cgccggaagt gaaaaaacgc acaccgatcc gcgaccgatt 826321 cactgaaatg taaaaaaccc cttgtctcaa acggagacaa ggggtttttc attaacgaga 826381 tttctttttc gctctgttgt cggctgcttt cgcacgctct tgcgcttcgc ggtcatctgc 826441 atcagcaagc tcggttgaat attcttcgta aacgccgtca gtttcccttt ttaaggcatc 826501 gggaacttgt ggaagctttt gtttgttttt atcacggttt ttgtggatat gatttctgcc 826561 catatcaaat tccccctaaa aagtgatatc aaacaaatat agtatttggt tttaaggggc 826621 tatgtattcc tacttccgct tagcagcttt ttccgctttt ttaaattcgc ctgaataaag 826681 aacttcctgc atttttttca ggttggcgcc ttgctggtgc ttctccctct ttttttccat 826741 aaaaaggacc tccttcaacc atgttattct taaggttgac gcttcctgct gtttttatac 826801 agtctttcgg tccgctatca gctgtgagag tgcaaattca agatccgaat atgtaaaacg 826861 aaatccagag gttatcgctt ttttcggaag agcgcgctgt cctttcacaa tcaaaagact 826921 catttcaccc aatgcttttg ataaaaagaa ttccgggacg gggagccagt gcgggcggtg 826981 cttcacccgt gcaatcgttt ttccgaattg cttcatgtcc acaggattgg gcgcggtgac 827041 attcattggg cctgagatgc cggcgttttc caccgcatat cggatcatct gggccgcatc 827101 ctcgacatga atccatgaca gccactgcct tcccgttccg atcgttccgc cggccagaaa 827161 cttatagggg agaatcatga gcgggagagc gcctttttct ccaagcatca cgccaaatct 827221 cgcataaact gtccggatgc ccatcgcttc aatatgctgt ccttcctttt cccacaggtg 827281 tgcagtatgg ctgagaaaat cctcatctga cgttgcagaa tcctctgtga aagttttctc 827341 aaggcttgtg ccgtaaatgc ccacggcact ggcttggatc aatgtcttcg gcttctcctt 827401 ctgtttctga ataagccgct gcacttcacg cgtcgcattg atacggctgg agagaatgtg 827461 ctgcttcgtt ttttctgtcc agcggccaaa aatcgatttt cccgcaagat ttatccagac 827521 atcaatatga ggaagttcct gctccggtgc ggctccttcc gacagccatt ggacatatgt 827581 catatttttt tgttcagttt cccttgcgtt tcttgataaa atataaacat ggtgtccctg 827641 gcgggtaaga acgcctgtca gatgctggcc gagaaaaccg gttccgcccg tcattgcgat 827701 attcatgaac atctctcctc atcgttctaa taaatatact ttacctcatt gtaataaaag 827761 aaaacgcgtt tcaggcctga gaagggagat taagatgccg tttattacaa aaatatcaac 827821 gcaaaaaaag aatacggaac gcttcaatat ttttctggat gataaatacg ccttcagcgt 827881 ggacgcggat gtgctcgtga aatttgagct caagaaggga aaagaactcg atgatcttga 827941 catcattgag attcaatacg gcgatgaagt gaagaaaggc ttcaaccgtg cgcttgactt 828001 tttatcctat cgaatgcggt cgacgaaaga ggtcgaggat cacttaaaga aaaaagaaac 828061 ctcgcccccc gtcattgcgg aagtcatcca taggcttaac gattacaagt acttaaacga 828121 ccaggaattt gccgcagcct atgtcagcac tcacaaaaaa acaaacggaa aaggccctga 828181 tgttttgttc agagagctaa gagcgaaggg aattgatgac gatacaatta aggaggcgct 828241 aagttccttt tcctttgaag atcagacaag agaagcggtc aagcatgttg aaaagcttct 828301 caaaaaagat aaaaagcttt cgacgaaaga actcaaacag cgcgcccagc tgcagcttca 828361 gcgcaagggc ttctcatttg atgttatcag cgcggcgatg gatcagattg aatatgaaaa 828421 tgatgaagac acagagaaag aagcgctgcg ccttcacgcg gaaaaagcgt ttagaaaata 828481 ccgctatgac ggctcatatg aaagcgccat gaaggtcaaa caatttttat tccgcaaagg 828541 attctcactc gatttaatcg agcaattact gcaggaagag gagtactgaa atggagaaac 828601 gatacagtca aatgacaccg catgaactca ataccgaaat cgcattactt tctgaaaaag 828661 caagaaaagc cgaacagcat ggaatcataa acgaactggc agtgctcgaa cggaaaatta 828721 cgatggcaaa agcatatttg ctgaacccgg aagattactc accgggagaa acatatcgtg 828781 tggaaaacac tgaggacgag tttaccatca gttatttaaa tggcgttttc gcatggggat 828841 acaggacctc ttcccctcag caagaggaag cgctgccaat ctcagtattg caagaaaaag 828901 aataaagcgt aacaggaggc tgatgatcag cctctttttg tttgcagcac atttacacga 828961 attcttaaag aaaaaatcat tgaattcact tgaaaaatct tttaagatga aactcgttgt 829021 tttttaaaat caaaggaggc gatgacgttg agtatcaaaa acccatctgt aaaatttatt 829081 atatttgttc ttatgatttg tacattttca atcggctata cagaatacgc ggtgatgggt 829141 attttgacgt cgattgccaa tgactttcat atacaggttt catccgcagg gcttcttgtc 829201 acggcttatg cggcaagcgt ttgtttgaca gggccgctcg tcaccatcat ttccgtcaag 829261 cttccgagaa agcctgtgct tcttgggctg atggcgatat ttatcctttc caacctgatg 829321 agcgcactgg cgccgaattt tgcggtattg gccatttcaa gaattttatc tgcgtccatt 829381 cacggcgctt tcttcgcgat tgccatggta ttcgcaagtg aaatggttcc gccggaaaag 829441 cgtgctgcag ctgctgcttc aatgaacggc ggactgacag tggctctaat gcttggtgtt 829501 ccattcggct cttatctcgg agatgtcctg aattggagag cggtgttttc catcattacg 829561 gcacttggtg tcatcggatt tttaggcctt atggctgccg tgccgaacag aaaaccaaaa 829621 gtgatcccaa tgcttatgaa tgagtggggt gtttttaaac acaaacaagt gctgttttcc 829681 ttcgcgatta ccattttagg ctattccggt gtctttatcg cctacacctt tatcgaaccc 829741 attttgaggc attcagccgg attcagcacg gttggcatta caggtgctct ctttgcgtat 829801 ggattgggag gcgttgccgg gaatttcttt gctggaaagg taccgctgcc tttgctgact 829861 cggacgatga tcggcgtaat gatcggttta atcggtgttc tggctgtatt tccttacatc 829921 gccatttacc cggctgcagc cattgtggca acgttcctat tcggggcatg cgcattcggc 829981 acgccgcctc ttctgcaaac aaaggtcatt tcctcatctg agggcggcac aaccattgcc 830041 gcagctgtca gcgtatcagc atttaacctt gccaatgccc ttggtgcatg gatcggcgga 830101 atgattttaa acggaacagg ctcttattcc tggctgtttg caggaggtgc gcttatgacc 830161 gcatgcggac ttgtgctttc taccttcgca cacttatcag aaaagaagag cgtctacgaa 830221 tatcaagtca ataaagggta aaaaacagct gcagtgtatg cagctgttct tctttaccgt 830281 ttgcctgagg ctctcattct ttcttgagga tgctgattga tagatccgtc agcacgcttt 830341 gaagcatagt cgtcctttgc tctcggttca ccctgaaatt tgttttcgtt ttcgtaagga 830401 aatccttttt ctttatttcg gaccatgtca tatcccccta ggttcgagat caaaaagttg 830461 cgtcttttca gatgaagacg taaggttagt atatggagaa caccacgtaa taaagcgtta 830521 tttttttcct gaagaaagga gactgcacac atgaatatgt acattgagaa actgactaat 830581 ctgcttctgg aaaagaacga gatgatcagc tatatacagg caaaaacgtg ggtggaattg 830641 ttatggagcg atttcgaagc aacctacgca aaagccggac acgcctatca aggtgaaaaa 830701 atgactgaaa aaatcgtcac acaatggatt gaaaactatg gcggccagct ccaccttttt 830761 caaagctccc gtaacgacgt gaatgattac ttaaatcaaa gcagaggcct tttgcattaa 830821 aaacctgccg ttaacgaccg gcaggttttt tcattttctt aaaattacct taacaggaag 830881 aaatcataaa caaaacatgt ttcaccagcc tgtcaatcag ggaataccac ttatatcttg 830941 tcaaaatgcg aggaggagct ttatatgaaa aagaaacaag taatgctcgc tttaacagct 831001 gccgcaggac tgggtttgac agcacttcat tccgctcccg cagcaaaagc tgcgcccctt 831061 cacgacatat ctgtcagcat gccatcatcc gatacttaca tcataaaagc aggaaagctg 831121 aatgtccgga ctgagccaaa tcatgaaggt gatattctcg gcactgtatc atcagaacaa 831181 aaggtaaaag tcgataggtt cgtaaatgcc gattgggctc aaattcattt caaaggaaag 831241 aaagcatata tttcaactca ctttttaatg aaaaccgcaa gccaagcgaa aacaacgaaa 831301 cagacagcct tctatacacc gacgcccgaa aacggaaaag ctaagcagct ctcatctgga 831361 acagaggtga caatacttgg gtggggattc agtgaaaacg gcggatttga cttcacttgg 831421 gcgttcgtgg attatggcgg agttaaaggc tatattcaca caaaggattt acaaatgcga 831481 taaaaaggca ggccgaggct tgtctttttg cctatgcatg aaacatttct tctttctgca 831541 cgtaacaatg agaaaggaga tgatgatatg acgggtttag tcggcggagg gcttatgatc 831601 attgcgggca tactgatcaa actgtttcct cccaaatcga tcaacagtgt gtacggatac 831661 agaacgagac gctcaatgtc agatcaaaga ttatggaatg aagcgaaccg ttacagtgca 831721 tcattaatga tcctgtcagg cttggtgatt gcgggaatgg gtttgctgct gggatcaaac 831781 ttgtttattc ttcagcttat cctgctgatt gccgcctgtg tcataacatt tatgctaacg 831841 gagaaaaggc tgaaaatcat gacgcacagt caaggaggag atagaagtgg acggagttaa 831901 atgccagttt gtcaatacga acggaatcac gcttcacgtt gcagccgcag gacgggaaga 831961 tggcccgtta attgtcctgc tccatggatt tcctgagttt tggtacggct ggaaaaatca 832021 aatcaaaccg cttgttgatg cgggttaccg ggtcattgct cctgatcagc ggggctacaa 832081 tctcagtgac aaaccggaag gaattgattc gtatcggatt gatacattaa gagatgatat 832141 catcgggctt attacgcaat tcactgatga aaaagcaatt gtcatcggtc atgactgggg 832201 aggagctgtc gcatggcatt tggcttccac acgcccggaa tatcttgaaa aactgatcgc 832261 gatcaatatc ccgcacccgc acgtcatgaa aaccgtaacg ccgctttatc cgccgcaatg 832321 gctgaaaagc tcgtatatcg catacttcca gctgcccgat ataccggagg catcactaag 832381 ggaaaatgat tatgatacat tagacaaagc gattggatta tccgaccgtc ccgcgctttt 832441 tacatccgag gatgtcagca ggtacaaaga agcgtggaag cagccgggcg cgctgacagc 832501 tatgctgaac tggtacagag ccctcagaaa aggaagcttg gcagagaaac cctcttacga 832561 aacagtacct taccgaatga tctggggaat ggaagaccgc tttttgagca gaaagcttgc 832621 gaaagagacg gaaaggcatt gcccgaatgg acatctcatc tttgttgatg aagcttccca 832681 ttggattaac cacgaaaagc cagccatcgt caatcagctg attttggaat atcttaagaa 832741 ccaataagct aaaatttctc tccatccgtc tgtcataatg gcagactttt tctgtgcgtt 832801 ttttttcata gtctgtttta aacatgacaa aataacatta aaaatcatga atgtcaccat 832861 aaaattgtaa caaaaaacag gtttaaacga ctttaaaaaa aggaatagcc ttactgaaga 832921 tttgtgtaaa actcccctaa ggcaatactt aaaaagaata ataaaaagaa ggtgccttaa 832981 tgaagcaagg attaatctcg attattatcc cgtcttacaa tgaagggtat aatgttaaac 833041 tcattcatga atctttaaaa aaggaattta aaaacattca ttatgactat gaaatattct 833101 tcataaacga cggaagtgtt gatgacacgc ttcagcagat caaagacttg gcagcgacgt 833161 gcagccgggt aaaatatata tctttttctc gaaactttgg aaaagaagcc gcaattttgg 833221 cgggctttga gcatgttcag ggcgaggcgg ttattgtcat ggatgccgat ctgcagcatc 833281 cgacatattt gctgaaggaa tttatcaaag gctacgaaga agggtatgac caagtcattg 833341 cccaaaggaa cagaaaaggg gacagctttg tccgctcact cttatcatct atgtattaca 833401 agttcattaa taaagcggtg gaagtcgatt tgcgtgacgg tgtcggtgac ttcagattgt 833461 taagccgcca agctgtgaat gcacttttga agctgagcga aggaaaccgc ttctcaaaag 833521 gccttttttg ctggattggc tttgatcaga aaattgtatt ttatgaaaat gtcgaacgaa 833581 aaaacggcac ctccaaatgg tcgttcagca gtctgtttaa ctacggaatg gacggcgtcg 833641 tttcatttaa tcataagccg ctgagattat gtttttatac aggcattttc atcctgctgc 833701 tttccatcat ttatatcatt gccacattcg ttaaaattct gactaacggt atttctgtgc 833761 ctgggtattt caccattatc tcagcagtgt tatttctcgg cggagtacag ctgttaagtc 833821 ttggaataat aggtgaatat atcggccgaa tctattatga aacaaaaaaa cgcccgcatt 833881 atttgatcaa agaggcgaat atcccgaaca aagacctgcc tgaaacgaac gaattaaaaa 833941 gcatgcggcg tctgacaaaa atgcactgaa aataccaagc gccattggca gtgctttttt 834001 tgcgtgtcta ttatcttaaa agcaagactg gagaattcat atgaaaagaa aacatatcat 834061 gatctatgcg gccagtttgc tggtgtccgt tctggcacac gctttttttg tgaaagaatg 834121 ggcggaaggc aggtatatga caggtccggg tgacgggctt gcgcaaatga tcgtatttaa 834181 aaaattatta tttgaccaat atacacacgg gaattttttc tacaattatt cattcggact 834241 tggcggcggc acattcagtc agctcggcta ttatttttct gcgtcttttc tttttcttgc 834301 tgtgtctgcc gctgtttggc tgcttcaagc cgtccagctg atcggagaaa cggatacgct 834361 tttttgggca gagtcagctg tttttatcag tattttcaaa ttgagcttga tcatctttac 834421 gtccgcttct gtttttcatt atcttcttaa gcacagggcg gcatcgttca cgggagccgt 834481 gttatacggc gtctcaatta tttatttccg tcacgaagcg tattgggaat ttttcaccga 834541 tacaatggtt tggcttccgc tgcttgtgct tggcgcagaa aaaattatta gagagcggcg 834601 tccggcgtgg tttatcgttg cgtgttcgct gacgttaatc aacaattttt actttgcata 834661 cataaacctt atattcatcg gaatctatgt gctgttcaga tggctgatcc gtttggaacc 834721 acatgaagag aaaagatgga ttcaaatcag attatttctc gtttcaggct tcatttcttt 834781 tggcatcagt gcggcggcgt ttgtgccggt agtatacggt tttttaaaca acctgcgccc 834841 tccatacagc cagaaaatag agtggctcaa tttcgatgat aatatcttat tttcgagccg 834901 gatcatcatt gtgccggccg cttttctgct gtttttgttt attatttctt tttacaaaaa 834961 ccgtgtgttt cgtctctttg ccgggttgag cctgctgttt attctgtttc atttcagtcc 835021 gtatgcggca agcgtcttta acggtttttc cgccccgcaa aaccggtttg aatatgttct 835081 ggcctttacc attgcgggag cagctgcggc tggtttgtca cagctgtctg aattgaaacg 835141 gaaagaactg ctcccggccg cagctgtcgt cctgcttctt tacttgtatc atatccaaag 835201 gtataagctc gatatatgga agcctgcgaa tgaaagtatt ctattgctct tactcatgac 835261 aatcgcagcc ttgtttgctg cagcttttgc gaaaaaacgg gcaaaaatgg ctgtgtacgg 835321 tataatcatt ctttcttcgc tgtttgtcgc caactcctat caaaaatacg cgctctcaga 835381 aggcggcgat ttggacagtg tgacaaaaga atatcttaca agtgaggaat acagagggcg 835441 ggaatcatct gagctcatca gacgtttaca gaaggaagac gatgacccgc tcatgagaat 835501 cgactggatg aacggggtcc gcaataatac gccaatcatt tacggattta atggcttcag 835561 cgcgtattcc agcattttaa acaaagatct gctggccttc tattggaatg atttaagcat 835621 cgatatgggc agggaaagcg tcagccgtta cgcgtcattg ggagacaggg cgaatttata 835681 cagcctgctt tacggcaaat attatatgac cgaaaaaaca aacgaagcca gcgtcccgta 835741 cggcttcaaa aagcatttag aaacagagca ttatgcagtt tatgagaatc agtacatgct 835801 tccattcgtt aaaacagcgg atgccatata cagcgaaagt gagctggacc gattgcccgc 835861 tcttgcgaaa gaacaggcga tgctgaaagg aattatatta aaagatccat caggaaaaac 835921 ggagcagaca ccaaaaccgt ccaatttgat caccaagtcg gacatcaccg caaaacaagc 835981 ccagtatcaa aacgggctgc taaccgtaac tggagaaaac ggaggagagc tgatcatcac 836041 cccgaaacag ccatcatccg ctccgggaga ctactatgtc agcttttatt tgaaaagcaa 836101 agcaaaagac aaaggattta cattaaaggt aaatgattat gtcacaacaa ggaaatcgaa 836161 caaatcgatc tataaaaccg gagtaaataa tataacggta agagtgccta aatcaggcca 836221 tatctcaatc aatcttccga aaggaaccta tgagctgaga aacatagcgc tctatgaaga 836281 aaattaccaa acgctgaaaa acgctgtaat gcaaaataaa acagagaaag cagacaaact 836341 gaattggaac aaaaatcgac tgaccttttc ctatcatctg tcaaaagacc agtacatcat 836401 gcttccgatc ccatatgaaa aaggctggga gctgaagatc aacggaaaaa cacagaagat 836461 cgaaaaagcg gattatgctt ttataggctt caaggcgcaa aagggagaca atcacattga 836521 gctgacttac tatccgccat acttcaaaat atcggcgatc atatctctcg tcagtctgct 836581 gcttgctgtt ttttatataa gacgtaaaaa gcccggctct atatagagcc gagctttaat 836641 tttttctgaa gtttttcttc gctgaatatc catcccgtat aggatgaacg aatcgtgaga 836701 tcatggccga tatgaacaat tgcgacaaac ggataatggc ctttgctccg ataacgcagg 836761 tcgataaatc tcacctcata atgatcttta aacgtatcca cttcccaccg gtataccgga 836821 gaaaaggaca gaaacgccgc gatgttatca tcctgctttg ccgcatgcat tacatcggtt 836881 tcaggaacag gcacccgatt aaatgtatcc agaatcacga catgtccttc catgcttctt 836941 cctacataga aagcatgtgc tgtcgtcact gcgattcgcc attgcctgaa tttcatcgtt 837001 ggagaaataa taatgctttc gatctcatca tgaatcatct catgaagctt ccgtttaatt 837061 ctcagctgca tgatcaggcg caccaagtag tagcctacca atatgatata taagctgaga 837121 aacgtgatgc cgggactccc gcctgcatac caaatcgcga tagctgccag atggctgata 837181 aaaataaacg gatcaaacgt attaatcagc ccgagcgcaa cccatttttt cgaaaacgga 837241 cgaatggctt gtgttccata ggcgttgaat atatcaacaa agacatgcag aacgactgcc 837301 agcagtgtcc acagccacag gtgcagaaaa tcggcctgag gataaaataa atacagaatc 837361 gccgggatga tgacagacca aaacaaaacg gcgggaattg aatgggtaaa tcctctgtga 837421 ttccttatat aaacagcatt gtttttaagc tttaacacag tatcaatatc cggagcctga 837481 gagcccgcaa gcgttgcgat cataacagcg tgagccattg ccggatctga tccgacaaca 837541 ggatcaagcg tcgcaatacc gcccagtgcg atgcccataa cgacatgtgt gcccgtatcc 837601 ataggtgacc tccttgcagg gtgatcctgc acattcactt tgtaagaaat tccccatttt 837661 catataccca atttttaaac tgattcaatc gttctcatat gtttccgctt tttctttatt 837721 actatttaat gtaacatatt atcgtactgt gcccttagtg tacaacaaaa aacagtctaa 837781 agaaaagcgg ggcgcgaaag actggggaga aacacatatg aacgtacttg aagacaaatt 837841 aaaacaaaaa gacatacagc aatttcgcga tgatttaatc tcatggtttg aacgagagca 837901 gcgcgttttg ccgtggagag aggaccaaga tccatataag gtgtgggtat ctgaagtgat 837961 gctgcagcaa acgagagtag agacagtgat tccttacttt ctccggtttg tagaacaatt 838021 cccgacagtg gaagcgctcg ctgatgctga tgaagaaaag gtgctgaaag catgggaagg 838081 gctcggctat tattcgcgag tcagaaacct gcaaagcgcg gtaaaagaag tgaaacagga 838141 atacggcggc attgttcctc cagacgagaa agattttggc gggttaaaag gcgtcggccc 838201 ttatacaaag ggagcggtgc tcagcattgc ctacaataaa cccattcccg cggttgacgg 838261 aaatgtgatg cgtgtcatgt ccaggattct atctatttgg gatgatattg ccaaaccaaa 838321 aacaagaacg atctttgaag acgccatacg agcttttatt tccaaagaaa aaccatctga 838381 atttaatcag ggcttgatgg agcttggagc cttgatctgt acgccaaaat caccctcatg 838441 cctgctttgc ccggttcagc agcattgctc agcatttgaa gaaggcactg aacgggagct 838501 tccggtaaaa agcaaaaaga aaaagcccgg gatcaaaacc atggccgcga tcgtactgac 838561 tgatgaagac ggacaagtgt atatccacaa acggccgtct aaaggtttgc tcgccaacct 838621 gtgggaattc ccgaatcttg aaacacaaaa agggatcaaa actgagcgtg aacagctcat 838681 tgctttctta gaaaacgaat atggcataca agctgatatc agtgatctgc aaggtgtagt 838741 cgagcatgtt ttcacccacc tggtatggaa tatttcagtg tttttcggta aagtaaaaca 838801 agtgtcggat accagcaagc tgaaaaaagt aacgaaagaa gagctcgaac aatttgcgtt 838861 cccggtgtca catcaaaaaa tctggaagat ggcaggagaa gcagccgcca tctcggctgc 838921 tccgtaaacc attcttaatc gtaagagacg cgcgtgccgt ggctgtagtc cgcttcattg 838981 cgcttcattc cgccgcgcgc ttcaatttct tgcgttaatt cccggtattt tgattggcct 839041 tcttcgttca aataaggcat aatttgctga aaggcatgat gaaaataagc gagttcactg 839101 ttcttccaat cttttttgga aaccatgttc aattcgctca tatcacgtcc gacatacata 839161 acagaagacc ccctttaaag ttcttgccat tattgtttgt ggaaataaaa gaactatacg 839221 ctacaaggag atgaggaaaa atggaacaaa ataaatgtgc actcgtaaca ggaagcagcc 839281 gcggtgtcgg aaaagcggcc gcgatcagac ttgctgagaa cggctataac atcgtcatta 839341 actatgcacg cagcaaaaaa gcagcattag aaacagcgga agaaatcgaa aagcttggcg 839401 ttaaagtgct tgtcgtaaaa gcaaacgtag gacagcctgc aaaaatcaaa gaaatgtttc 839461 agcaaattga tgaaacgttc ggcagacttg atgtttttgt caataatgcc gcttcaggag 839521 tactaagacc tgtcatggaa ttagaagaaa cacactggga ctggacgatg aacattaatg 839581 cgaaagcatt gcttttctgc gctcaggaag ctgccaagct aatggagaag aacggtggcg 839641 ggcatattgt cagcattagt tcattaggct ctatccgcta tcttgaaaac tacaccacgg 839701 tcggtgtatc aaaagcagcg ttagaggctt taacccgtta tcttgccgtt gagctttcac 839761 caaaacaaat tatcgtcaat gctgtttcag gcggagcgat cgacacagat gcgctgaagc 839821 acttcccgaa tagagaagat ctgcttgagg atgcgcgcca aaatacgccg gcgggacgca 839881 tggtcgaaat taaagacatg gttgatactg tggagtttct agtgtcttcc aaggctgaca 839941 tgatccgcgg acagacaatt atcgttgacg gcggacgctc actgctcgtt taaaaatttt 840001 taaaaaagag gaatagctat acgatcacct gcacattcta atgaccgtgg aggtgataac 840061 aatggctaac tcaaataact tcagcaaaac aaacgctcaa caagttagaa aacaaaacca 840121 acaatcagct gctggtcaag gtcaatttgg cactgaattt gctagcgaaa caaacgctca 840181 gcaagtcaga aaacaaaacc agcaatcagc tggacaacaa ggtcaattcg gcactgaatt 840241 cgctagtgaa actgacgcac agcaggtaag acagcaaaac caatctgctg aacaaaacaa 840301 acaacaaaac agctaatcac tgaaacagaa aaaagcactt catcttcggg tggaagtgct 840361 tttttctgtt tgaaaaacga caaaacttgt ggaaggtcta cagaatgagt caaagggttt 840421 gctttatgga gatcgaaatg attaaaggag gaaatgttta tactttcatc aggctgaagg 840481 aggaaccgat gaccgaattt gaaaagctgg taagtgaaca gatgaaaacg atggataagc 840541 ttctcgatct ccaatcagag ctcgaccgct gcaaacaaat tgaggcggaa ctccggcatt 840601 tggaaaggga tgcaaggctg cgtgggattc aggctgaaat tgcggtaaaa cggaaacacc 840661 ttgccgatat acaggatatg tttcaaaagc agacagagca ggtcattcgt tcatatcgca 840721 gctcagaaaa gccgtcttcc tttgtgtagt gcaggaatgt gccattcccc ggccggaatg 840781 gctcttttat tttcattttt caatttgtaa cgttataata ggtaaaagac gttgtcggta 840841 agcaaatttg gacatactaa ctgtagggct ttatagaaag taggggagaa atatgggcta 840901 tcccaaggaa ggagaaacca ttcaaattca cagctataag cacaacgggc tgattcatag 840961 aatttggaat gagacaacaa tcttaaaaag tacagaaatg tgtgtcatcg gagccaatga 841021 ccggacgatg gtaaccgaat cagacggccg gacatggata accagagagc ccgcaatctg 841081 ttattttcac gcaagacaat ggtttaatgt catcgggatg ctgagggaag acggggttca 841141 ttattattgc aacatcagtt ctccgtttgc ctatgatggc gaagcaatta aatatattga 841201 ttatgactta gatgttaagg tttttcctga catgacctac aatattctcg atgaagacga 841261 atatgatgat catcggaaag ccatgaatta tccaaaagaa atcgacagta ttttaagaga 841321 ctacttaaat acgctgctcc attggattca ccagcgtcag ggaccgtttg cgcccgagtt 841381 tgtcgatatg tggtatgaac ggtatttgcg ctatacaaaa taatggttac gtaaaaacct 841441 gttgcggggt acaacaggtt tttcacatgg gctcacacac atcatgataa agagagaggg 841501 ggaatcaacc gtgggggtta tgaaacgcta catgcaattc gtcaaacctt ataagaagca 841561 aattttcgtt acagtgttaa tcgggatcgt aaaattctcc attccgcttg ctctcccatt 841621 gcttctgaag tacgtagttg acgacattat tcaaggaggc ggcacggcca gtgacaaaac 841681 cacgtcattg ttcacgatta tggcgatcat gttcgcctta tttttaattt tgcgcccgcc 841741 tgttgaatat taccggcaat attttgccca gtggactgcc agcaaggtgc tttatgatat 841801 aagagctaag ctgtttgacc atatacaaaa actgagcctt cgtttttacg cgaatacaag 841861 aacaggggaa gtcatttccc gagtgattaa tgatgtagaa caaacaaagg atttcgtcat 841921 cacagggctg atgaatatat ggctcgatat gctgacgatt ttgattgtaa tctctatcat 841981 gctcacactg gacgttaaat taacgctgat ctctatcgtt ttattcccat tatacggaat 842041 atcagtgaag tatttttacg gccgtttacg aaagctgaca agggagcgct cacaggctct 842101 tgctcaagtg caggggcatt tgcatgaacg cattcaaggc atgcctgtca tcagaagctt 842161 tgcgatagaa gatcatgaac aggctcaatt taatgagaaa aacggtcatt tcttagataa 842221 agccatccgc cacacgaatt ggaacgcgaa aacctttgcg gtcgttaata ccattacaga 842281 tttggcgccg ctcatcgtca tagcgtgcgc cgggtatttt gtcattaatg gaccgctgac 842341 agtcggaaca atggtcgcgt ttgtcggata tattgacaga atgtacaacc ctgttagaag 842401 gctgatcaat tcctctacaa ctttgacaca gtcaatcgca tcaatggaca gggtgtttga 842461 atttattgac gagccctatg aactcactga caaaccaaat gcgataaagg ccgatcagat 842521 tcgcggagga gtggagtttc aaaacgtttc gtttcaatat gagaaggaca aagaaaatat 842581 tcttcatgat gtatccttaa aagtaaatag aggagaaact gtagctctcg tcggcatgag 842641 cggaggagga aaatcaacgc tcgtcagcct gatcccaaga ttttatgatg taacaagcgg 842701 cagactgctg attgatggga cggatattcg cgattatgaa gcaagaagcc ttcgcaacca 842761 ggttggtatg gtgcttcaag ataccttttt atttagtgaa acgattcggg aaaatatcgc 842821 gatcggcaag cctgatgcca cacttgaaga gataatcgaa gccgccaaag ctgcaaatgc 842881 ccatgaattt atcatgagtt ttccagaagg atatgagacc cgggtggggg aacgaggcgt 842941 taagctttca ggcggacaaa agcagcggat ctcaattgcg cgggtattcc tgaaaaatcc 843001 gccgctcctc attttagatg aagctacatc agctctggat ttggaaagtg agcattacat 843061 tcaagaagcg atggacaaac tggcgaagga tagaacaact tttgttgtcg cccaccgttt 843121 atcgacaatc acccatgcgg ataagattgt tgtcatggaa aacgggacaa tcattgaaat 843181 cggaacccat gatgaactca tggactatga gagccaatac aagcacttat ttaccattca 843241 aaatttgaac taaaacatca atcttatatc cttttaacga aggatataag atttttttgt 843301 atataaaaaa acccggctgt ttaaccgggt tactcttctg tttctatttc gcagtctttc 843361 ggatgatacg tttgaaaact tgtgataagt gtttctaaat gttcaagctg ctcgcgatat 843421 tccacggcgc ttgccataat attgagcatg ttgtaatcaa taagctcctc atccgtattc 843481 tgctgatttt ttaaaaatga ctttgttaaa agctgcttat accggatgcc ttcttcaacc 843541 gcgtcatcat gcggcttgat ttttccgaca aacctcatca aaatccgctc gtgccagtaa 843601 agcaggtaat caagttcttc agtcaatgtt tcctgaaact cttccggcat atgatagatc 843661 tcgttttcca gacgatgcag cttcttcaat gtatcaagcg cccgatttgc agtaataatg 843721 gcctgtctga acaggacaag ctttcttgat ttcacataag tcgttttctt aaagtaactt 843781 ctttcttctt tatatagaag atatgtctga tcaagcttga tcattttttc tttcagtttt 843841 tcaatatcct ctttcaaaat cgaatgctct gtcgactgcc gcatggacaa tctgatccac 843901 ttcataattt cttcggtgtt ttcgacggta ttatgaatca gctttgtttc gtacttagga 843961 ggcaaaaaca caaggttgac gataaaggaa gaaagcaccc ctaagatgac tgtgcttgtt 844021 ctgatcagcg cgaacattaa aaagtcgtca ccggcagatt ctaatatcgc aatgactgtt 844081 acaagagcaa ttgaaattgt atgttcaatt ttaagtttca gcatgattgt aatgacaata 844141 actgctgtta acccgatcat aatcgggctg ggtccgaaaa taaggccgaa cactgtggca 844201 atcacagctc cgatgatatt tgcttgaacc tggtcaataa taatgagaaa agagcggtaa 844261 atcgacggct ggatcgcaaa tatcgctgca attccagcga aaatcggcgc gggaagcccg 844321 atccacgaag ccaaataaag ggcaagtgta atcgcaatcc cggttttgaa aatgcgggca 844381 ccaagtttca ttggtttgtg cgtgcattcc tttctatagt aaattgtgtg acatagcaaa 844441 tgggctaatc cttaaaattc ccggttagtt tatttgctaa acaattaagt aatatacagg 844501 gatcgataca aatattcaag ctatttttct agaaaaagac caaaatctta cacgctgttt 844561 gattccataa aaaaacagga gctcaaagct cctgttcaag gtatttgatt ctagtttttt 844621 agatgtttaa atgcatcctc gaccgctgta agcgtgtctt taatatcctg ctctgtatgt 844681 gctgtggtaa taaaccaagc ttcatactta gaaggtgcta aattaattcc gcgttccagc 844741 atcagcttga aaaacgtaga gaatgtttct ccgtcactcc gttcagcctg ctcgtaattt 844801 tccactttct catcagagaa gtataccgtg agcgcacctt ttaaccggtt gaccgtaatg 844861 gtgatgccgt gtgtttctgc gtgcttcaaa atgccttcct caagcatagc gccaaggtga 844921 tcaagctttt catacacgcc tttttctttg agcacttcca gacaagcgat gcctgatagg 844981 atggaagcgg ggttccctgc cattgttcct gcctgataag caggccctag cggagctacc 845041 tgctccatga tttcttgttt gccgccatag gccccaatcg gaagtccgcc gccgataatt 845101 ttcccgagtg ctgttaaatc tggtttcacc tgtaagagat cctgcgcgcc gccatacata 845161 aagcggaaag ccgtaatgac ttcatcgtaa ataacgagag cccctgcatt atgtgttaat 845221 tcatttactt gttctaagaa gccctctttc ggctccacga taccgaagtt gccgacaatc 845281 ggttcaacga gaaccgccgc gatttcactg ccccattttt caagagctgc tttatagcta 845341 tcgatatcat taaatggtac tgtgatcact tcgtttgcaa tgcttttcgg tacaccggct 845401 gagtctggtg tgccgagagt agacgggccg gagcctgcgg cgacaagcac aaggtccgaa 845461 tgcccgtgat agcagcccgc aaatttaatg atttttgtcc ggcctgtata tgcgcgagcc 845521 acgcggatgg tcgtcataac ggcttctgta cccgaattga cgaatcttac tttgtccata 845581 gcgggaatgg cttctttgag catttttgca aatgtaacct cgtgtttcgt tggtgttcca 845641 tacaatacac cgttctctgc tgctttttta atcgcttctg taatatgcgg atgggcatgt 845701 cctgtaataa tcggaccgta cgccgctaaa taatcgatgt atttgttgcc gtccacatcc 845761 caaaaataag cgccgcttgc tttctccatt gcaacaggag aaccgccgcc gactgcttta 845821 tatgatctag acgggctgtt tacaccgccg acaatgtgct gtaatgcctc attgtgaagt 845881 tcaattgatt ttgtatgcaa gaataaaaac ctcctatatc tccatgcgtc ctttctattg 845941 tagcatgctt ccgaacaaga acaatggctt cgggcttcag attcagctga gatggttgta 846001 atctggacaa gaattggata cgcttaataa aaaaacatcc ggaggtaacg taatgactat 846061 agaaatcgga caaaaagcgc ctgatcttga gttaaaaggt gatcatgggg aaacagtaaa 846121 attatcggat tataaaggaa agtacatcgt gctttatttt tatccaaagg acatgacacc 846181 gggatgtaca actgaagcat gcgattttcg ggacagtcac gaaagcttcg ccgaactgga 846241 tgccgtcatt atcggcgtca gcccggacag ccaggaaaaa cacggaaaat ttaaagagaa 846301 gcataacctt ccatttctgc ttcttgttga tgacgagcat aagctggcgg aagcatttga 846361 tgtgtggaag ctgaagaaaa acttcggaaa agagtatatg ggaatcgagc gttccacttt 846421 tttaattgat aaagaaggcc ggctcattaa agaatggaga aaagtaaaag taaaggacca 846481 tgtagccgaa gcgcttcaaa ccctcaaaga tatgtctgaa aagtaaatct ctatgagcct 846541 atgcttactt ttaccctgat atcaattgac aaattatcgt agaaagagtt acactaatta 846601 taaacattac aatgtaagaa ttttttttag aagagaggtg catgacggat ggctgcacat 846661 gaactaaaag aagccttaga aacgttgaag gaaaccggag ttcgcattac tcctcaacgt 846721 catgcgattc tggaatatct cgttaactct atggctcatc caacagcgga cgatatatat 846781 aaagctctgg aagggaaatt tcctaacatg agcgtagcga cggtatataa caatttgcgt 846841 gtgttccggg aatcaggttt ggtaaaagag ctcacatacg gtgatgcttc cagcagattc 846901 gattttgtca catccgatca ctatcacgcg atttgcgaaa actgcggtaa aattgtggac 846961 ttccactacc cgggccttga tgaagtggag cagctcgctg cccacgtcac gggcttcaag 847021 gtaagccacc accgtttaga aatttacggc gtctgccaag agtgttcgaa aaaagaaaat 847081 cattaaaaat aagctgaccg cacgaaacgg tcagcttatt ttatttcgac attttctttt 847141 tattataaga ctcatcaaat tcttttcctt ctaatccctt atctaaagtc agcggctctc 847201 ggcaatgcat gcacatatcg actactccta aaacctttgt ctctttatca cagcctggac 847261 aaatgacgcg aaccgcttta gtcgaaagca ttccgatcca aaagtaaact accgtgctga 847321 gaccgatgga taaaagccca agtatcataa acaaactaga aagcaaaact gactctttga 847381 aaaagatccc gatgtacata atgataaacc caacgaaaac caaacttaac gcaaatgttc 847441 tgattttatt aattttgctg gagtatttcg ccatgtccat ccccctctgt tttaactata 847501 gcacaaaccc gatgggattt tcttcatgtt ttcggttgaa ctggaattta catatggaga 847561 gttactgtga aattgtttat aatagttcaa tgtgtttaga aaaaaggaat ttcgttttaa 847621 ccatagaatt gaatcaaata gagaataaaa aaatttgaac aattgcattg gaggaatagt 847681 gatggaaaat cttctccgtc caatttacca agaaagagca agtcacccca atacattggc 847741 tgtcattatg attgagagaa gaaacaaaac atcttcctta acagataact ttgatgcagc 847801 tttgctggtg attgtaaagg atgctgatga gccagttttt ataaagcatt atgaatttga 847861 tcatcaaaca gcttctttgc atgtggtaac agattctcag attcaagaat ggattttgct 847921 tggaacaaat agaagaatca tagattggat tgtaaatggc agagtcttgt ttgaccgtaa 847981 tgaatacgta gttgaactga ttgacaggct gaatacattt ccgtttgccg aacgtaaact 848041 gaagatcgga ctcgaatacg gcaaattaat cagaaggtat gttgaaggga aagctttttt 848101 tgaagccaat caatttttag atgcctacaa tgccgttgtt catgcgctgc atcatttagc 848161 acgtattgaa gtaatcgaca gaggattcca tcccgaaacc acggtgtgga gccaagtgcg 848221 ccagatggag ccccaagtgt acaaattata ttccgagctg attgaaagtc atgagagcct 848281 ggaaaaaaga cttgaattat tattcttagc aaatgatttt ctcatccatt ccaaagccga 848341 gatcggttcg gcgcatcttt tcgaagtaat gaaagaaaaa gacatttggc aattcggtga 848401 gcttcttcaa catcatgacc taaagcactt tacccaagat cttggcgtta tgcttgatta 848461 cttgacggaa aagggactta tcaacgtctg ccagatagaa acgaaaggac aggctgtcta 848521 tcaccgagga tattctttta aaaaaggtgt tgactctgat tcttgaccgt gttatattat 848581 taaacgtcgc tgatgcgctt ctgagaaaac aagctcacag cggcgggaaa ataaatcaaa 848641 aaaacatttg acaaaagaaa gtcaaaatgt tatattaata aagtcgcttc aacaagaagt 848701 gaaaatgatc tttgaaaact aaacaagaca aaacgtacct gttaattcag tttttaaaaa 848761 atcgcacagc gatgtgcgta gtcagtcaaa ctagggcctg cacgacgcag gtcacacagg 848821 tgtcgccgca ggatgcggtg aacttaacct gtgatccatt tatcggagag tttgatcctg 848881 gctcaggacg aacgctggcg gcgtgcctaa tacatgcaag tcgagcggac agatgggagc 848941 ttgctccctg atgttagcgg cggacgggtg agtaacacgt gggtaacctg cctgtaagac 849001 tgggataact ccgggaaacc ggggctaata ccggatggtt gtttgaaccg catggttcaa 849061 acataaaagg tggcttcggc taccacttac agatggaccc gcggcgcatt agctagttgg 849121 tgaggtaacg gctcaccaag gcaacgatgc gtagccgacc tgagagggtg atcggccaca 849181 ctgggactga gacacggccc agactcctac gggaggcagc agtagggaat cttccgcaat 849241 ggacgaaagt ctgacggagc aacgccgcgt gagtgatgaa ggttttcgga tcgtaaagct 849301 ctgttgttag ggaagaacaa gtaccgttcg aatagggcgg taccttgacg gtacctaacc 849361 agaaagccac ggctaactac gtgccagcag ccgcggtaat acgtaggtgg caagcgttgt 849421 ccggaattat tgggcgtaaa gggctcgcag gcggtttctt aagtctgatg tgaaagcccc 849481 cggctcaacc ggggagggtc attggaaact ggggaacttg agtgcagaag aggagagtgg 849541 aattccacgt gtagcggtga aatgcgtaga gatgtggagg aacaccagtg gcgaaggcga 849601 ctctctggtc tgtaactgac gctgaggagc gaaagcgtgg ggagcgaaca ggattagata 849661 ccctggtagt ccacgccgta aacgatgagt gctaagtgtt agggggtttc cgccccttag 849721 tgctgcagct aacgcattaa gcactccgcc tggggagtac ggtcgcaaga ctgaaactca 849781 aaggaattga cgggggcccg cacaagcggt ggagcatgtg gtttaattcg aagcaacgcg 849841 aagaacctta ccaggtcttg acatcctctg acaatcctag agataggacg tccccttcgg 849901 gggcagagtg acaggtggtg catggttgtc gtcagctcgt gtcgtgagat gttgggttaa 849961 gtcccgcaac gagcgcaacc cttgatctta gttgccagca ttcagttggg cactctaagg 850021 tgactgccgg tgacaaaccg gaggaaggtg gggatgacgt caaatcatca tgccccttat 850081 gacctgggct acacacgtgc tacaatggac agaacaaagg gcagcgaaac cgcgaggtta 850141 agccaatccc acaaatctgt tctcagttcg gatcgcagtc tgcaactcga ctgcgtgaag 850201 ctggaatcgc tagtaatcgc ggatcagcat gccgcggtga atacgttccc gggccttgta 850261 cacaccgccc gtcacaccac gagagtttgt aacacccgaa gtcggtgagg taacctttta 850321 ggagccagcc gccgaaggtg ggacagatga ttggggtgaa gtcgtaacaa ggtagccgta 850381 tcggaaggtg cggctggatc acctcctttc taaggatatt atacggaata taagaccttg 850441 ggtcttataa acagaacgtt ccctgtcttg tttagttttg aaggatcatt ccttcgaaac 850501 gtgttctttg aaaactagat aacagtagac atcacattca attagtaata caagatatca 850561 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 850621 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 850681 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 850741 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 850801 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggattagcc caaaccaaga 850861 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaagaac gaggtagatg 850921 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 850981 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 851041 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 851101 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 851161 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatccc 851221 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 851281 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 851341 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 851401 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 851461 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 851521 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 851581 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 851641 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 851701 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 851761 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 851821 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 851881 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 851941 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 852001 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 852061 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 852121 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 852181 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 852241 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 852301 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 852361 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 852421 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 852481 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 852541 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 852601 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 852661 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 852721 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 852781 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 852841 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 852901 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 852961 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 853021 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 853081 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 853141 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 853201 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 853261 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 853321 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 853381 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 853441 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgagggct 853501 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaat aagtttttca 853561 aaaaaacact tgattttctc aagaatacat agtataatgt taaatgtcac tgaaattgtc 853621 tggtgatgat ggcgaagagg tcacacccgt tcccatgccg aacacggaag ttaagctctt 853681 cagcgccgat ggtagtcggg ggtttccccc tgtgagagta ggacatcgcc aggcagactt 853741 cattccgcag tagctcagtg gtagagctat cggctgttaa ccgatcggtc gtaggttcga 853801 atcctacctg cggagccatt attggagagc tgtccgagtg gtcgaaggag cacgattgga 853861 aatcgtgtag gcggtcaact ccgtctcaag ggttcgaatc ccttgctctc cgccactgat 853921 acttatacat aattacaatt gaaagtctgg gcccgttggt caagcggtta agacaccgcc 853981 ctttcacggc ggtaacacgg gttcgaatcc cgtacgggtc attatatgat ggaggattag 854041 ctcagctggg agagcatctg ccttacaagc agagggtcgg cggttcgagc ccgtcatcct 854101 ccaccattat atcatcgcgg ggtggagcag ttcggtagct cgtcgggctc ataacccgaa 854161 ggtcgcaggt tcaaatcctg cccccgcaac caaattttaa aatggtccgg tagttcagtt 854221 ggttagaatg cctgcctgtc acgcaggagg tcgcgggttc gagtcccgtc cggaccgcca 854281 tttgaatact taggctcggt agctcagttg gtagagcaac ggactgaaaa tccgtgtgtc 854341 ggcggttcga ttccgtcccg agccaccacc tatgccggtg tagctcaatt ggtagagcaa 854401 ctgacttgta atcagtaggt tgggggttca agtcctcttg ccggcactgt tttttcaaaa 854461 tttaatgtgg aggggtagcg aagtggctaa acgcggcgga ctgtaaatcc gctccctcag 854521 ggttcggcag ttcgaatctg cccccctcca ccatttatag gggcatagtt taacggtaga 854581 acagaggtct ccaaaacctc cggtgtgggt tcgattccta ctgcccctgc caaatttatg 854641 acatcttgag attatggcgg ttgtggcgaa gtggttaacg caccagattg tggctctggc 854701 actcgtgggt tcgattccca tcaatcgccc catattatca ttgggctata gccaagcggt 854761 aaggcaacgg actttgactc cgtcatgcgt tggttcgaat ccagctagcc cagtctcact 854821 ttttatatca actgcatata atgtattaag tccattaaaa atgcggaagt agttcagtgg 854881 tagaacacca ccttgccaag gtgggggtcg cgggttcgaa tcccgtcttc cgctccaatt 854941 acggcggcat agccaagtgg taaggcagag gtctgcaaaa cctttatccc cggttcgaat 855001 ccgggtgtcg ccttcttatt gccggggtgg tggaattggc agacacacag gacttaaaat 855061 cctgcggtag gtgactaccg tgccggttca agtccggccc tcggcaccaa ttttacttac 855121 atggtaagtt gaattggtgt ttgtgtttta tcattataac taatcatatt aatgatctac 855181 ataagtagat cattttttta atgctttgat ttatcataac aagttaagtt ccgaggccta 855241 ttataaagcg gctgtatagc tagtctttca acacttttat tttatatttc cataaaaact 855301 tttttgaaat acgttgacac tttatgagat ccatgatata tttatattcg tcggttagat 855361 acgacgtaaa acttgccggt gtggcggaat tggcagacgc gcacgactca aaatcgtgtt 855421 ccttctggag tgtcggttcg accccgacca ccggtatact gaaaaacccg tttcttaaca 855481 gaaacgggtt tttatttttt attaaagaaa aggagcctcg gctccttttt atacttactc 855541 agcgtattgg tctaggatct cttctagcac ctcttctagc tcttctgtat cttcaagctc 855601 tgattggctg aaacggacgc gtacaagctg ttctccgtca ttatacatct cttccaacca 855661 ccctcggagt cctcttgctc tgcggtcgac ttcgaaaatg atttccaaac cgtcttcgtc 855721 taaaaggaaa atgagctcta attcatcaag catctgacga taatatccgg aagtcggaac 855781 gaattcgaat tcttgaacga acggaagacg acgctggaag tagggcgctt gttcgcagtc 855841 tgcttcgtta agacggaagc ccaggttttc gattgcttca agcacatttt caatccaagg 855901 gtgcgcttca acgaaaatgc ggtcatgatc ggatttatcg ataccgcctt gaatgtcaag 855961 gtctgtcacc acggcaacct ctactttccc tacagtgatc ggcgtatcta gaggcagagt 856021 gaatgtgaac ggaaattgat gctcttcacc aggctgtatg gtaaatgaac cagtgacccg 856081 gaaagaatga attgtagcgt atttccggtg ctcttcatcg tcttttacaa tgacataccg 856141 tgtgctaagc tgtaaatcga tataacggat gtcctgagcg atttttccgc ctttgacatg 856201 taccgttccc tgtacttctt ctcctggaaa atatgcgtct ttttctaaaa ttgtatctac 856261 ttttgcagct ccaattccgg cacttgccgc aagcttctta aaaaatgaca tgttagatct 856321 tccccttttt cttttttctc aacagatata cgtaagaagg aggaaaaaag attcgtttga 856381 ttcatacttt tttcctatta ttcgtctcgg cctagggaca gactaagaat aatattgaaa 856441 ataaaggagt cgatggaagt gaataaagaa agtttggttg cagatgaatt acacagaatg 856501 tttttggctg gtgagctgca aatcacagta gaggaggata taaacaatat ttccgaaagg 856561 ctgagaaacg gcgatctcag tttagaccga ttaagcggtg aagacgtgtt tataaaagaa 856621 acggtaaatg aggctttaag aagagtggag caataaaaaa gagacggcat ctcatctttg 856681 agatcccgtc tctttttgtg gtctttgctg taagataaaa gcgaatcgat ttggaattgc 856741 tcacccgagc cacccctttt ctaacagaag atctgacagt tcatcatgga gataaacagc 856801 tgtatctaat tgatcatgca atgctcttct gatgtgggga ttttcggttg ctgttgttgc 856861 gacagtgtat ttgttaatgc tggtttttat tgttgttaac aaatcaagaa tatctttggg 856921 acaaagactt tgttcaatgg gaaaccacct cctttgtttt tttagcagct cctgataaga 856981 aagtatttga ctttgtttct tgcttctata caaaatgcta taataagcaa caaattttgt 857041 tggggggtgt gatgatgaag cagattattg cgatgggggg cgggggtttt tcgatggagc 857101 cggataattt gtccctcgat caatatatcc tcaatcaatc aaaacgagag cagcctcgta 857161 tttgtttttt gccgacggcg agcggagatt cccaaaacta tattcagcgg ttttatcatg 857221 catttcaaac attggattgc gtgccgtctc atttatcttt gtttaagcca ccatcatcag 857281 atttagtttc ttttgttatg gaaatggacg tgatttatgt tggcggggga aatacgcgga 857341 atttacttgt gttatggaaa gagtgggggc tggaccatat tctcagggaa gcatggaaga 857401 acggtgtggt tgtagctgga ataagtgccg gtgcgatctg ctggtttgaa gaaggggtga 857461 cagattcagc cggaccgctg acaagtttga aaagtttagg ttttttgcaa gggagctttt 857521 gtccccatta tgacggggaa aaggatcgga gaccggcata ccaccagctg atatctaaca 857581 agttcttatg cagtggctat gcagcggatg atggggctgc tctccatttc ataaatgatc 857641 agctgtttca gactgtgagt tcaaggtcgg gtgcaaaggc atatcgggtg atgatggctg 857701 aacatgaaat agctgaaatc ccgttgccgg tcaaatattt agggtgaaat tggctgaata 857761 ttatctatat tcctcttttt ttcagattga ttttatgata agatgagtgc gaaatcaata 857821 gttactgggg gtgcccgctt tcgggctgag agagaaggca agcttcttaa ccctttggac 857881 ctgatctggt tcgtaccagc gtggggaagt agaggaattg tttttgttat tgtcttgctg 857941 ggcaataata tgtttctttc tgactgtaac cgggttcatt tatatgaatc cggttttttg 858001 tgctggttat gggcttgatt ttgtcctttc aaacgtagaa aggggaagga aaagtaatgc 858061 aaaacaattc agtgcagcaa gccaacattt ccattatgtc aagtttttca ggcagcaaga 858121 aggtatacgt ggagggttct tcttcggaca tccaagtgcc gatgagggag attgcattga 858181 gtccgacgac gggatcgttc ggcgaagagg aaaacgcgcc tgtgcgtgtc tatgatacaa 858241 gcggaccgta tacggaccct gaagtaacca ttaatattca agaaggatta aagccgctcc 858301 gccaaaaatg gatcacagag cgcggtgacg tggaagagta tgaaggtcgg gctataaaac 858361 cagaagataa cggttataaa aaagcaaaac caaacgtaag ctatccagga ttaaagcgga 858421 aaccgctgag ggcgaaggca ggtcaaaatg tcacacaaat gcactatgca aaaaagggga 858481 tcattacacc tgagatggaa tttatcgcca ttcgtgagca tgtgtctcct gaattcgtca 858541 gagacgaggt agccagcggc cgggcgatta ttccttcaaa cattaatcac cctgaaagtg 858601 agccaatgat tatcggccgg aattttcatg tgaagattaa tgcaaatatc gggaattcag 858661 cggttacgtc atccattgaa gaagaagtgg aaaaaatgac gtgggccatc cgctggggag 858721 cggatacgat gatggatctc tctaccggaa aagatattca tacgacgcgt gaatggatta 858781 tccgcaattg ccccgtgcct gtgggaactg ttccgattta tcaggcgctt gaaaaagtaa 858841 acggcgtagc tgaggattta acgtgggaga tttatcgtga tacgctaatc gagcaggcag 858901 agcagggagt ggattatttt acgattcacg cgggtgtttt gcttaggtat gtaccgctga 858961 ctgccaaacg gacaactggt atcgtgtcac gcgggggagc gattatggcg cagtggtgtc 859021 tggctcatca tcaagaaagc tttttataca cacattttga agaaatatgt gagattatga 859081 aaatgtatga tattgctttc tctcttgggg atggtttgcg tcccggatca attgctgatg 859141 ccaatgacga agcgcagttt gctgaattag agacgcttgg agagctgacg caaattgcct 859201 ggaagcatga tgttcaggtg atgattgagg gtcctggaca tgttccgatg cataaaatca 859261 aagagaacgt cgataaacaa atggacattt gtaaagaagc gcctttttac acattggggc 859321 cgttgacaac ggatattgct ccgggatatg accatattac ttcagcgatc ggagcggcga 859381 tgatcggttg gtacgggaca gcaatgcttt gttatgtaac gccgaaggag catttggggc 859441 tgccaaaccg tgatgatgtt cgtgaaggag tcattacata taagatcgct gcgcacgctg 859501 cggaccttgc aaaagggcat cccggagcgc aaatccggga tgatgcgtta tcgaaagccc 859561 gttttgaatt ccgctggcgg gatcagttta atttatctct tgatccggag agagcccttg 859621 aataccatga tgaaaccctg cctgctgaag gagcaaaaac cgctcacttt tgttccatgt 859681 gcggtccgaa attttgcagc atgagaattt cacaggatat tcgggattat gcgaagaaaa 859741 acgatctcag tgaagcagaa gccataaata aaggattaaa agaaaaagca aaagagtttg 859801 tcgatacggg aagcaattta tatcaataaa aaaaatgaag atggagaatg ctccatcttc 859861 atttttttag aaaaacagag agcgtcgaag cggaggaata ctctgttcaa agcggaaaac 859921 attttctgga tcatatgtcg ttttgacacg gcggagtcgt tcaacgtttt cgccgtaata 859981 tgttcttggc cagtttctga tttcgatatc tggccaattt acgtagtctc ccatcgtttc 860041 tttcgaaagg gacgttctca gcccctcaat ccagcggaca ttttgtcttt tttctccagg 860101 ggatgtccag tttgttaagt attcctgggc gatgattgcg tcacgataat aaaatgccgt 860161 ttggtcggga gcgacccgtc cggctgcccc gccgagtgct tgctgccaga cactggcgtt 860221 ttgattcgga gcgtgctcta aaaagtgttt tattgttgag atcgcacgtt ctgataatgg 860281 cttttcaatg aaagagccgg agcgtttcat tttttgaggc tgattgcctc ccgggctgtt 860341 aaaaaaggtt accgcttcaa tgaatggcgt tgtttttacc attccgcttg tcggacttcc 860401 tgctttcaat aaaggcttta acagtttttt taactctgtt tttggcccga caaattggcc 860461 gagggcttct atgcggttta cttctttagg ccaaaactct attgatgatg taagccggtc 860521 atctgtatac ggggcccagt tctgccacgt gttatatact tcctcaaaat catcccatcc 860581 ccatgtaata gaaaaaatcg acacttgaga gatgggcact gctttaaatg tcatggaggt 860641 gactatgccg aaattgcctc ctccgcctcc ctgagacgcc caaaataagt ctggatgatt 860701 tgaacagctg actgtaatca gatcagcgcc ctctttttcg tctgctacga tcatctcaag 860761 ctgcacgagg ctgtcgcaag taagaccggc agcccttgtt aaaagtccaa ttccccctcc 860821 gagagttaaa cctgtgagcc ctacattagc aatggtgcct gcgggaagcg tcaggccgta 860881 ttgccagagt gtccgataga cttctcccaa ttcagccccc gcttcaatat aggccagctt 860941 tttatcctga ttcacagtta tttttttcat ctcgcttaaa tcaataacaa gaccgttatt 861001 taaaagggaa aagttctcat agctgtgtct gccgcctcta atacggaaag gcacacggtt 861061 ttcacgcgcc catttcagcg cattgagtgc atcctgtttg ttttggcaaa acacaatgat 861121 gtcaggatac ctttctaagc ttaggttaat attggttctt gcttcgttat agtccggatc 861181 atcccgtgtc acgatacgtc cggtcaattt tgtcttttcc acactcccac atctctttct 861241 ctcgtattct agtttctcta gcttatgcgt caggggaaaa gagtgtataa ggaaaaagcg 861301 gggatgcaat ctgatacagt gtcaacaccc tcaaaaaata gttgacaggt cggtattgta 861361 tgaattaaca tggtcagtac aaatttttca aatttatcgc gctgatcgga acaccgaagg 861421 ctcttatcgt ttagataagg gccttttttg tatgaaaaag gggggattat tgatgggagt 861481 caaaaaagaa aaggggagaa aacgattcag gaagcgaaaa acctacggga atcagatttt 861541 gccgcttgag ctgctgattg aaaaaaacaa acgagagatt ataaacagcg cggaactcat 861601 ggaagaaatt tatatgaaga ttgatgagaa gcatacgcaa tgtgtaacta aatataaaaa 861661 aacccgctga ctacaacggg tttttgcatt tctccattaa gaatcttttt taatcggcaa 861721 tccaaggcct tctgccacgc gttttccgta ttcaggatcc gctttgtaga agtgctcgat 861781 ttggcgcagc ttgatttctt ctttttctac cggcttcatg gcattaacga tattttcaac 861841 aaggcgggta cgttcatctt cactcattaa acgatacaga tcgccggctt gagtgtagtg 861901 atcgtagtga tcgtagctta cgctgtcagc gataccttgt accggatatg ctgcttgctt 861961 atcctcaggt gactcttttg gaccgccgaa gctgttaggc tcgtaataca cagatccgcc 862021 gccgttatca tcaaaacgca tttgcccatc acgctgataa ttgtttactt tgttgcgtgc 862081 gcggttgatt ggcagcgctt gatggtttgc accgacacgg tagcggtgtg catcatgata 862141 agcaaaaagt cgaccttgaa gcattttatc cggtgaaaca tcaataccag gcacgagggt 862201 tccaggtgaa aatgtcgctt gttctacctc tgcaaagtag ttttccggat ttctgtctag 862261 aaccatgcgt ccgacctcga ttaacgggta gtctttttga gaccaaactt ttgtgacatc 862321 aaacggatcg aaacggtacg tatttgcatc ttctaaaggc atgatttgca catatagttt 862381 ccatgcagga taatcaccgt tttcgattgc gttgaaaagg tcttctgtat ggtaatcagg 862441 gttttcaccg gcaatttttg ctgccgtatt gacatcaagg tttttcacgc cttgttctgt 862501 tttaaagtga tatttaatcc atacgccttc gccttcggca tttgtccatt tgaatgtatg 862561 gcttccgaag ccgtgcatgt ggcgaagtgt cgcaggaatt ccgcggtcag acatcaggat 862621 tgtcacttgg tgcagtgact ctggtgaaag tgaccagaaa tcccatacag ccgtagggtt 862681 tttcaggtgt gtttttggat ctcttttttg tgtatggatg aaatcaggga acttaatcgc 862741 atcgcggata aagaatacag gcgtattgtt gccgacgatg tcgtagtttc cttcttcagt 862801 ataaaattta acagcaaatc cgcgcgggtc gcgaactgtg tcagcagagc caagttcacc 862861 ggcaactgtt gagaaacgga tgaacaacgg tgtgcgtttg ccgacttcag aaaggaaagc 862921 ggctttcgtg tattttgtta cgtcgtttgt cacttcaaaa tatccgtgtg cgcctgctcc 862981 tttggcgtga acaacacgtt caggaacacg ttctcggttg aaatgggcca atttttcgag 863041 taaatgtaca tcttgaatta aagttggtcc gcgagaaccg gcagtcattg agttttgatt 863101 atctccaacc ggagcgcccc agctagttgt cagtttattt gaactcatgt tatcacctct 863161 tggaatttat aagaacataa tatcatctct aagtaaaaag tcaatattat tttataatta 863221 ttataaaata gttatctcta ttaatcgata tatagtatcg aaattgttga aaaaccttgt 863281 tgtaacagct ttttatgaca cttaataatt tttggagaaa taatttttcc ttctctattt 863341 gcgaaacaag cagagtaagt gataaacaag gatatcaaaa atcgtattta aaaaagagtt 863401 gacatatcgg aataatttga attaacatgt tattcaaaca aaaaaacaat tgggcagctg 863461 atcggaccgc cgaaggctct catctctaca agaacagaga tgggggcctt tttgtttttt 863521 ttgaaggcgg ggttggcaga aagagaggga taaaagtggc tgtgaccatc agcatcaaag 863581 aaaaggcatt tgttcaagaa ggccgcaaaa acacggtctt agaaaacata gaattatcaa 863641 tcgcaccagg cgaatttcta acgcttatcg gaccgagcgg gtgcggaaaa agcaccctgt 863701 taaagattat tgcagggctt gattctgaat atgacgggag tgtggaaatt aacggccgca 863761 gcgtaacagc tccgggtatt cagcaaggat ttatttttca ggaacaccgc ctctttcctt 863821 ggctgactgt tgagcagaat attgcagccg acttgaattt gaaggaccca aaagtcaaac 863881 aaaaggtgga tgaactgatc gagattgtca gattgaaagg atcggaaaaa gcatatccgc 863941 gcgagctgtc aggcggcatg tcacaaagag tagccatcgc ccgggccctg ctgcgggagc 864001 ctgaggtgct gcttttagat gaaccgtttg gtgcactcga cgcttttaca agaaaacacc 864061 tgcaggacgt gctgctggat atatggagga agaaaaaaac aacgatgatt ctcgtgactc 864121 atgatataga tgaatctgtt tatttaggaa atgagcttgc gatccttaag gccaaaccgg 864181 ggaaaatcca taagctgatg cccattcacc tggcgtatcc gcgaaaccgg acgactccgg 864241 atttccaagc gatcagacag agagtgctgt cggaattcga gaaaacagaa gatttggagt 864301 acgcagaagg atcagggata tagaaagggc ggaagcggaa atgaaaaaag gactcattgt 864361 attggttgcc gttatttttc tgctcgcagg ctgtggagca aatggagcca gcggtgacca 864421 caaacaattg aaggaaattc gtattggtat tcagcaaagc ttaagccccc ttttgattgc 864481 aaaagaaaaa ggctggttcg aagatgcatt tgaaaaagaa ggcatcaaag tgaaatgggt 864541 ggagtttcaa agcggtccgc cccaatttga aggccttgcg gcagacaaac ttgatttttc 864601 tcaagtcggt aattcgcctg tgatcgctgg acaggcggca ggcattgact ttaaagaaat 864661 cggtttgtct caggacggct tgaaagcaaa cggcatcctt gtcaatcaaa acagcggcat 864721 tcaagacgtt aagggcttaa aggggaagaa aattgcagtc gccaaaggca gcagcgggtt 864781 tgattttttg tataaagcgc ttgatcaagt ggggttgtca gctaacgatg tgacaattat 864841 tcagcttcag cctgatgaag cagcttccgc atttgaaaac ggatctgttg atgcctggtc 864901 catttgggag ccgtacttgt ccttagaaac aatgaaacac ggagcaaaaa tccttgtgaa 864961 cggagaaagc acagatttat attcaccggg ttttacttta gtaagaacaa agttttcaga 865021 agagcatcca gacgaagtgg tccgttttct gaaggtgttt aataaagccg ttgtatggca 865081 aaaggaacat ctggatgaag cagcggactt atattctgac attaaagatc tcgataaaaa 865141 ggtcgtcgaa aatgtgctga aaaatactga gccacttaat gagatcatca gtgacgacat 865201 tgtgaaagca cagcaggaaa cagcagattt tcaatttcga acaaaggcga tagataagaa 865261 gattgatgtg aaggatgttg tcgataacac ttttatcaaa aaagcattag aggagcattc 865321 ctcaggaggt gatcaatgat gaaagcagag gctgcgggct cgctgcccaa aacgaatgcg 865381 gaagcggtgc gaaaaaagcc cggaaggaag agatacggct ggatgaaggg gcttttactg 865441 cccgctgtca tcattgccat ctggcaggtc atcggcgggc tgggggttgt gtccgctaca 865501 gtgctgccta cacctgttac gattgttctg acctttaagg agcttatttt gtccggcgaa 865561 ctgttcggcc atctgcaaat cagcatttat cgggcggcac ttggtttttt gcttggcgcg 865621 gggcttggat tgatgatcgg gattttggcc ggattttcca aacggacgga gctgtatctt 865681 gatccgtcgt tgcaaatgct tagaaccgta cctcatctgg ccgtcacgcc gctgtttatt 865741 ttatggttcg gatttgacga agtatctaaa attttgctga ttgcgctcgg tgccttcttt 865801 cctgtctata tcaatacgtt taacggcatc cgcggggttg acgcgaagct gtttgaagtc 865861 gcccgggtgc ttgaatttaa atggcatcag cagatatcca aagtgatatt gccggcagcc 865921 ctgcccaata tattgctagg cattcgctta tcgctcggca ttgcatggct cgggctcgtt 865981 gtggcagagc tgatgggctc aagctcggga gtcggctata tgatcatgga tgcgagacag 866041 ttttcacaaa cgaataaagt ctttgcaggg attatcattt ttgcagtggt tggaaagctg 866101 acggattcct tcgtcaggct gcttgaacga aagctgttaa agtggagaaa cagctacgaa 866161 ggataaaaga tataaagggg agatgaatat ggaaattctt tggtttatac cgactcatgg 866221 agacgcgaga tatttaggat ctgaaagtga tggacggact gcggatcatc tttactttaa 866281 acaagtcgcg caggcggcag acaggctggg atatacagga gttcttctgc caacgggaag 866341 atcgtgcgag gacccgtggc ttacagcgtc ggcactggca ggagaaacaa aggacttaaa 866401 gtttttagtc gcggtaagac ctggtttaat gcagccttct ctggcagcca gaatgacatc 866461 caccctagac cgcatttcag acggccggct gctgatcaac gttgtggcag ggggcgatcc 866521 gtatgagctg gcaggcgatg gcctgtttat cagccatgat gagcgctacg aggcaacaga 866581 cgaattttta accgtttggc ggagactttt gcagggagaa acggtttcct atgaaggaaa 866641 gcatataaaa gtggaaaaca gcaatctgct tttcccgccg cagcaagagc cgcatccgcc 866701 catctatttc ggtggttcgt cacaggctgg aattgaagct gccgcaaagc atacagacgt 866761 gtacttgaca tggggtgagc cgcctgaaca agtaaaagaa aagatagaaa gagtcaaaaa 866821 gcaagcggca aaagaaggga gatccgttcg atttggcatt aggctgcatg tcattgcccg 866881 tgaaactgaa caagaggcat gggaagcggc agagcgcttg atcagccact tggatgatga 866941 caccattgcc aaagcgcagg cagctttgag ccgttacgac tcttcaggcc agcagcggat 867001 ggccgtcctt catcaaggcg atcggacgaa gcttgaaatc agcccgaatc tgtgggcggg 867061 gatcggcctg gtcagaggag gggcaggaac agctcttgtc ggtgatccgc agacgattgc 867121 cgaccggata gcggagtacc aggcactcgg catagaatcg tttatattct ccggctatcc 867181 gcatttagaa gaagcgtatt attttgcaga gcttgtattt ccgcttttgc cgtttgaaaa 867241 tgatcggacg agaaagcttc agaacaaaag gggagaagcg gtaggaaaca cttattttgt 867301 caaagagaaa aatgcatgag tttaactaaa atacagcccc ccgaacatgg tatgatattc 867361 aaaaaaaggg ggcttttttt ctgaaaacat tgagaagcgc ggcagtcatt tgcctcatag 867421 ctatgctgtc agcatgcgga cattcaaaac agatggaaat caaagcggcg gacatatcag 867481 atcttgaaaa aaacagaatg gatgtcgcag cttcacaggc attcactgcc gaagccgtca 867541 atatcggtga aggtatttct tcagctgaca tgtacatcga acattatcaa aagggaaagc 867601 ttgttgagag gtttggaccg gttcgtgcag attattcaga ggaaaaaact gataccatac 867661 aatttgttta ttttgagaat gaagaggggg aaggaaagaa taaacatacc accattcatt 867721 ttggcattgt ggataaacag ggaactatag cggctgattc atcggtgaaa cgcgacgata 867781 gcacaacaca ggaaatgact cagaatattt catcgccgga accgattact ttcgagaagc 867841 ctgctttgat cggcagcagt attagaggga ctgacgagac aatgcacacc tctgaacata 867901 aaaaagagct cattaagcat caagatgcgt tactgtatta tgtggaattg catcattaga 867961 atgggcggct tcaggccgtc tgttttacaa agcggtatgc ttgctttttt gaatggtgaa 868021 tgatacattt taaatcgtaa caatttcgat ttaaagggag gctatgtgac ttggctaaaa 868081 aatcaaaagt ggcaaaagag ttaaaacgcc aacagcttgt tgagcaatac gctggtatta 868141 gacgcgagtt gaaggaaaaa ggagattacg aggcactcag caagctgcca agagattcag 868201 caccgggaag gcttcacaac cgctgcatgg taacggggcg cccgagagca tatatgagga 868261 agtttaaaat gtccagaatc gctttcaggg agctggccca taaaggccag attcccggtg 868321 tgaaaaaagc aagctggtaa gaaaaaactc cggccgatta cagcgcgccg gagttttttt 868381 cgtttttctt gaaagagatg acgtaggaaa ggtgctggat gatcatgatg ataaacacaa 868441 taataatagg gaaaaacgga atgcgcgatt gaaatagcgg ataaaaaatg agaagaaccg 868501 ctgcggcagg cagcgagaag tagacagcga tatatgacgc gcgacatgct tttgccgtca 868561 tcatctgctc tctttcatcc tgctcttcaa actcatcagg cagaagtagc tgctttctgg 868621 cagggcggct ttttttctgt aagtacaaat aaaccgcaga cgccgcaaca aacagaataa 868681 agggagtgag gtttaaatca aataccatcc cgccgctctt tgtgccgaaa aaagatgcta 868741 tgccttctga ggcttcaaag tatgaaatca gcgcccagca tgcaaggcca aataaaacaa 868801 ggtgaaaagc tgcttttgtt ttcatgctca tcttagtttt cctcctctaa ccaaaagaca 868861 tcctccattt tcatggagaa ggctttgcag attttcagtg ctaacagcag tgagggaaca 868921 taatcgcctt tttcaatcgc tgccacagtc tgtcttgtga cgccgaccgt ttctccgagt 868981 ttttcctgag aatagccgaa gcgtgccctc agctctttta ctttattttt catcatgacg 869041 tctgtcccct tcacaatctc gattgattat attgtatagt atacttaaca ttatgtaaat 869101 ggaacttaac aactttacaa aaagataact ttttttcgac aaaattttta tattcccttg 869161 acgaaaaata aataaacatg taatataaaa aaagtcagag cggtactgtt gctgacaatc 869221 acaaatgcgg gtgtagttta gtggtaaaac ctcagccttc caagctgatg tcgtgagttc 869281 gattctcatc acccgctcca tacatacgtt attaacgcag tgtttcgttt ctcagataaa 869341 cgaagtattg cgttttttta tgtgaaaaag aacacggtat tcgtgttctt ttacgtaagc 869401 caatgtactg tatgggtgcc gccgtgaatt tgttcaaaca ttttcgttaa tgatgataag 869461 aggttaacag cgctgctttt ctcaatcgat ggcgggaaaa aaatgatttg cagcatattc 869521 ttagtctcgt ttgaaacggg atagtggttg acgctgtttt tgaaatcgcc aaaaatgccg 869581 ttttcatcag agaaaagcag tatgttttct ttttctccca atgagatccg gaccggctca 869641 tgaagctttc cggcatcata aatcataata ggcagagaat attttaatgc gaaaaaatcg 869701 attgtgtcat gggccgagtc tttactttcc atgaattgtt ccttggatat cgggaccagc 869761 atgtcctcca ttggggttgt ttctccctca aatgaagggt taagctgttt aaagagtttc 869821 tgccattcct tgacgaagga ttcatcggat ataccgccgt ccgcatagtc gaaaaacaag 869881 gattcttgaa acaggcggag tctgcctttc agcatttgcg gtgaggagcc gacttcgata 869941 ttctcataaa tgacagcagc tgcatgtaag ccggccgcac gttcagtaat aacagaatca 870001 agtttgatat tcactagcat tcactccagt tacgtgatat caacctatta taaacgctgt 870061 gtcgttttat cacaaagaaa ggaggctgtg caaaacatga acgtttatca gctcaaagaa 870121 gaattaattg aatacgcgaa aagcattggc gtagacaaga ttggttttac gaccgctgat 870181 acttttgaca gtttaaaaga ccgtttgatt cttcaagaat cactcggcta tctctccggc 870241 tttgaagagc cagatatcga aaaaagggtg acgccgaagc ttcttttgcc gaaagcgaaa 870301 tcaatagtgg caattgctct cgcatatcct tccagaatga aggatgcgcc gagaagcacg 870361 agaactgagc gcaggggcat tttttgcaga gcttcctggg gaaaagacta tcatgatgtg 870421 ctgagggaaa agcttgatct gctggaggat tttctaaaaa gcaagcatga ggatatcaga 870481 acgaagtcaa tggttgatac aggtgaattg tctgatcgcg ccgttgcgga acgtgccgga 870541 atcggattca gtgcgaaaaa ctgtatgatc acaacacccg agtatggctc ttatgtgtat 870601 ttggcggaaa tgatcacaaa tatccctttt gagcctgatg tgccgattga agatatgtgc 870661 gggtcctgca cgaaatgctt ggacgcctgc ccaacgggag cactggttaa tcccgggcag 870721 cttaatgcgc agcgctgcat ctcttttctg acccagacaa aaggattttt gcctgatgaa 870781 ttccggacaa aaatcggaaa ccgcctgtac gggtgcgata cgtgccaaac ggtatgccct 870841 ctcaataaag ggaaggattt tcatcttcat ccggaaatgg agcctgatcc tgagattgcc 870901 aaaccgttat tgaagccgct tttggccatc agcaatcggg aatttaagga gaaattcggg 870961 catgtctcag gttcttggcg cggaaaaaaa ccgattcagc gaaacgccat tctcgcgctt 871021 gcccatttta aggatgcttc cgcactgcct gaattgacgg aactgatgca caaggatccg 871081 cgtcctgtca tcagggggac agccgcatgg gcaatcggaa aaatcggaga ccccgcctac 871141 gcggaagagc ttgaaaaagc gctggaaaaa gagaaggatg aagaggcaaa gctggaaatt 871201 gaaaaaggaa ttgagttgct aaaagcttca ggcatgacta aacaaggcct gtcctgacat 871261 acgtatagag cagaaggaaa aaacacttga gatcatccaa gtgttttttc tctataaaaa 871321 agtatggcgg gtggggtgag cttgaagtac attttagaac aattagcgga ggagcggctg 871381 ggctttctgg ttaacgggca tgctatgaga caggagtctc aagtcggaga ccttaaagtc 871441 atggagcgta agaaaaagct tctggaaaaa cgtaaagttg acatcataaa agcgaaagca 871501 aaggccgtga ttaatcatgt gcgggttgag gatgacggaa cgacctgcct ttcgtatacc 871561 atccattacg aatacgtgtg taaggaacaa gatgacagct tgtatataga agagcacata 871621 gaggagcgaa tggctttcct gtatgatcac attttgatta gtgatcagga aattgcgaaa 871681 aagccggctg gatttcatga agggaccagt attattgact attctgaagc tgaagaggaa 871741 agagaagcgt ttggcagggc ttttcaatac gatcgtctcg gcgctgtcca atatgccgag 871801 aaattttgga acaagcgcaa tcctgcttat aaaaatttca gcgataactg tacaaatttt 871861 atttctcagt gtcttcatgc aggaggcgcg ccgatgcgcg gtcatccgaa caggggatca 871921 ggctggtgga tgaaacaaag ctcatggagc tacagctgga cggtggctca ctctatgaaa 871981 atgtatttgt cgaattcaaa ggccggactg cgtgcggtgc gggtgaaatc agcggaagaa 872041 ctgatgccgg gcgatgtgat ttgctatgac ttcgaaggag acggccggtt taatcataca 872101 acgattgtcg tggcaaagga caaaggcaat atgccgcttg tcaacgccca gacttatgac 872161 agcaggatga ggtattggtc atatgaggat tctacggcat acacgccgtc aatacgatat 872221 gccttttttc atatcgttga tgatacgaca aaagagtaat taatgttata atgatgggcg 872281 gataagaaaa acagaggtga acattgtggc attacatgtc gttttatatc aaccagaaat 872341 tcccgctaac acagggaata ttgcacgtac ttgtgcagca accaatacaa cgctacacct 872401 gattcgtccg ctcggctttt caacggatga taaaatgctg aagcgtgccg gactcgatta 872461 ttgggagttt gttaacgttg tgtatcatga ttcgttagaa gaattgtttg aggcatataa 872521 aaaaggcaag tttttcttta ttacaaaatt tggccagcag cctcatacat catttgatta 872581 cactgatctt gacgaggatt atttcttcgt gttcggaaga gaaacaagcg gtttgccaaa 872641 ggatttaatt caaaataata tggaccgctg cctgcgtctt ccgatgacag agcatgtcag 872701 atcgttaaat ctgtccaata ctgccgcgat tcttgtttat gaagcgctgc gccagcaaaa 872761 ttaccgtgat ttaaaatagt gaaaaacccg ctcatcgatg atgggcgggt ttttttgcgg 872821 atgttgaaat gctttgtttc gtttttgggc ttaacaacgt aacagtgtta tgttacaatg 872881 tacccatcaa aggagctgga cttatggaag aacaattaat ctctaaaaaa gaattacttg 872941 aaagaacatc gatttcatac ggtcagctgt atcgatggaa gcggaaaaac ttaatacctg 873001 aggaatggtt tattcgtaaa tccacattta cagggcaaga gacgtttttt ccgagagagg 873061 agattttaaa acgtatatca atgattcaaa agatgaaaga aaatttgtct ttggatgaaa 873121 tgagggaaat gctgtcgccg aaaatgaagg atgtcagcat gaccgctgat gaattgcttc 873181 ataaaggttt ggtttcaagg cctgctcttg aagcctattc agaagacgga ggaagtccgg 873241 ttttttcatc cagcgatttg ctttcgctgt ttgtgcttga gggcctgctg cagtctggaa 873301 atgtcagcct tgcagaagca aaaatggctg cagaggtatt aaagaagcat gatactgaag 873361 agattgaaaa acagacggag ctgattgtgc tccgcaagct cggtgtcaca acttgtttta 873421 tagcggctgc ggcggacagc attttgtttg aatcatccgt aaaggttgtg gaacgggtag 873481 atttattaaa agcttcagag gaattaaaaa caacatttat gcaggagggc catcaatgga 873541 tgtagtggaa aagctggtga taaatggatc aggaagttct aagggaggaa catttcaatc 873601 agttgagatt aatggcagcg ggacagtggc cggggacgtg gagtgtgaca ctttttcttt 873661 taatggaaac ggaaaagcgg acggcagcgt caaagcgaaa gcggtaacta tcagcggttc 873721 aggaaagata catggagacg ttgaagcaga atctatccgg atgaatggca ctggttttat 873781 tcaaggagag gtatctgcaa aacaattgaa aatcgctgga tcatcaacat ttggcggcac 873841 tgtcaaggct gatggaattg acattagcgg aaaagctgtc atggaagcag attgtgaaac 873901 agaaaccttt caatcagaag ggaaatgcaa aatcagcggg cttttaaatg cagaccaggt 873961 gatcattaag ctttctgcag gggaaagcta tgcgcgggag atcggctgcc gccatcttca 874021 agtgacctgc agaaaaggaa tgctgacatt gctcagattg atgccgcagc ctgttctaac 874081 agcagagctg atcgaaggtg acgtgattga attgacaaat acaaaggcga aaaccgtgcg 874141 cggtaataaa gtgatcatcg gcccggattg ccagattgaa accgtcgaat acagcgggga 874201 ctatacctgt gatccaagcg cgtcggttga aacatccaca aagttgtaag gaggatcgta 874261 atggagacaa caaaactggg aaatttaaaa ttatatggcg ctgggcatgc cgcaggaggc 874321 gcgtatcaca atgtcagcat caaaggagaa ggtatagttg gagaagggct gtctgctgta 874381 ggctgccgca tatacggaac gggccttttt ctcggaaaag cagagactga gcggctgcgt 874441 gtgctcggag aaagtgaatg taaaggcgat ctgacagccg gcaaaatcaa tatatatggg 874501 acaatgaaag tcagcggctc acttcaattt gatcgattca atctgaaagg ccagactgaa 874561 attggcggga atatgactgg agaatcctgc gatgtgaaag ggaagcttag cgtaataggt 874621 gattgtgaaa cagaaatgtt ccatgtcaca ggctgtgttg atgtatcggg gttattaaat 874681 tcgggtgaga tcaagctggg attgagccat gatataagcc atgtgcagga aatcggcgga 874741 acaacaatta cagtgaaaag acgcgcgagt ttttttagcc ggaagaaagg gaagctgatc 874801 gccgatgtca tagaaggaga tcgggtttat ttggagaata ccgaagcggc agttgtcagg 874861 ggaaaagaag tgatcatcgg gccgggatgc agcatcggaa cgattgagta cgaatacaaa 874921 tgtgaatgcg atccgcattc acagattaaa gaaaaaacaa aactgtaaaa cattgttctg 874981 ttatacaaaa agggtgctct ttcaggagca ccctttttta ttcttttcca ggcttgcttt 875041 cgtatcctgc ggtaaaaatt gatactaaaa aagtgacaat gacacccatc atgatgattg 875101 ttttcaccgt ctctccccct cttcaatttt tccgtgctgt ccgagtctgg atgattctgt 875161 atttttcttt attatgaacg gtcgcagtct gccttgtcaa cgatgtatga gtatctttat 875221 ttttaagaaa ccaaagcatg tatcacgaga tggcggcata gattgtatca aagtacctta 875281 tttgcatagt gtatcaaaca tgatagagga ggtccttatg gatatattaa agaaaattga 875341 aaagtacaga gaggaagagc agcggctgaa atgggaagga actttcgccg attatttgga 875401 gattattaaa gaaaatccga tggtcgcgca atctgctcat tctcgagttt ttaatatgat 875461 aaaagacagc gggatagagg agattgacgg acgcaagaag tacagttttt ttgaccgcga 875521 gctgttcggg cttgaagaat ctctggagcg tcttgtggaa gagtattttc atccggctgc 875581 caaacgtcta gatgtcagaa agcggattct attgctgatg gggcctgtga gcggcggtaa 875641 atccacgctg gtcacaatgc ttaaaaaagg tctcgaagcg tacacgctga cagataatgg 875701 cgctgtatat gcgattaaag gctgcccgat gcacgaggac cctctacatt taatccccca 875761 tcatttacgc gatgactttt acagagaata cggcattaga atagaaggaa gtctttctcc 875821 tttaaatgtc atgaggctgg aggaagagta cggaggaaga attgaggatg tgaaggtgga 875881 gcgcatcttc ttttcagaag ataagcgtac gggaattgga acattcagtc cctctgatcc 875941 gaaatctcag gatattgccg atttgacggg gagtattgat ttctcaacaa tcgccgagta 876001 cggttcagaa tcagatccgc gcgcttatcg atttgacgga gagctgaata aagcgaaccg 876061 cgggatgatg gagtttcagg agatgctgaa atgtgatgag aaatttctct ggcatttgct 876121 ttccttgaca caggaaggga attttaaagc tgggcggttt gcgttaattt ctgctgatga 876181 gctgatcgtg gctcacacga atgaaacgga gtatcgctca tttatttcta ataagaagaa 876241 tgaagccctg cactcaagaa tcatcgtgat gccggttcct tataatttaa aagtgtctga 876301 ggaagagaga atttatgaaa aaatgattgc agaaagcgat gtggcggatg ttcatattgc 876361 cccgcatacg ttgaaggtcg ccgcgatgtt ctcaatcctt acccggttaa aagagccgaa 876421 gcggtcggat attgatctgg tcaagaaaat gagactgtat gatggggaaa gtgtggaagg 876481 atataactct gtcgacgttg aggatatgaa aaaagaatat aatgatgaag gcatgagcgg 876541 aattgatccg cggtacgtga tcaaccggat ttcttcaacg attatcagaa aaaatatgga 876601 atcgattaat tctctcgatg tccttcgctc cttaaaagaa ggtcttgatc agcacccatc 876661 aatttcaagc gaggacaggg agcggtattt gaattttatc tctgccgccc gcaaggaata 876721 tgacgatatt gcgaaaaagg aagttcaaaa agcgtttgtt tattcatatg aagaatcagc 876781 aaaaacactt atggacaatt acctcgataa cgtagaggcc tattgcaata aaaacaagct 876841 tcgtgatcct ttgacaggag aggaaatgaa ccctgacgaa aagctgatga gatccatcga 876901 agagcagatc ggcatttcgg aaaacgccaa aaaagcgttc cgcgaagaaa ttttaatccg 876961 catctcggcc tatgcgagaa aaggcaagcg gtttgattac aattcccatg aaagactgcg 877021 tgaagctatt cagaaaaagc tgtttgctga tctgaaggat gtcgttaaaa ttacgacctc 877081 aacaaaaacg ccggatgagc agcagctgaa aaaggtaaat gaagtcgtgg cccgtttaat 877141 tgatgagcac ggctacaact cgacgagcgc caatgagctg ctgaaatatg tcggcagcct 877201 gctgaaccga taagcaacgt gacccgtccg aatagggcgg gttattttgt cccattttct 877261 aaatagtttg tcaattaaac gtgcatatgt gcatatgatg aatataaatc ttttcaaaag 877321 acttgtttca taatctggca caagccggaa tacgtatgta tcacgaccac aaatggttaa 877381 ggaggggaat tcatgtccca aaatgacagc ggccattttt tgatttctga ggaaaactgg 877441 tccctccatc gcaaaggctt cgatgaccag cagcgccacc agaaaaaagt gcaggaagcg 877501 atcaaaaaca atcttccgga cctcgtaact gaggaaagca ttattatgtc taatggaaaa 877561 gatgtagtga agatcccaat ccgttcactt gatgagtata aaatccgtta taactatgat 877621 aaaaataaac atgtagggca aggagacggc gagagccagg ttggagatgt tgtggcccgg 877681 gatggatcag acaaaaaaca agggcctgga aaagggcagg gtgccggtga tcaggcaggc 877741 gaggattatt atgaagcgga agtttcatta atggatttag aagaagcgct ttttaaagaa 877801 ttagagcttc cgaatctcca gcaaaaagag cgggacaata tcattcatac agatatcgag 877861 tttaatgata tccgtaaaac agggttaacc ggtaatattg ataagaaaag aacgatgatg 877921 tcagccttta aacgaaacgc aatgtcagga aaaccgtcgt tctacccaat ttatccggag 877981 gacctgaaat ataagacgtg gaatgacatc acaaagcccg aatcaaaagc cgtcgtttta 878041 gccatgatgg atacaagcgg cagtatgggg gtttgggaaa aatacatggc cagaagcttc 878101 tttttctgga tgacccgttt tttgcggaca aaatacgaga ctgtggaaat tgaatttatt 878161 gcccatcata cagaagcaag agtggtctcg gaggaggatt ttttctcaaa gggagaaagc 878221 ggcggaacaa tttgttcttc cgtatatcgg aagtcgcttg agcttattga tgaaaagtac 878281 aatcccgccc gctataacat ttacccgttt catttttctg acggtgacaa cctgacatct 878341 gataacgcgc gctgtgtgaa gctggtcaat gatattatga agaaggccaa tctgttttgc 878401 tacggcgagg tcaatcagta caacaggcat tcaacgttaa tgtctgcata taaaaatgta 878461 aaagatgaga aatttaagta ctatatttta aaacagaaat ctgatgtttt tcaggctcta 878521 aagaactttt tcagaaatga agagtctggt gtaagccatc aattttcgta atgaaaagcc 878581 catttcaggg ctttttttta tttaataaaa gcaagaaaac gcttgcgaaa aaaatacggg 878641 agaaaaagaa atttttcctt tgacaaatct tctttcattt attaatattt tatcttgtga 878701 actattattg aggaatgagg tgaaaaggag ttgactgaat cagaacgtgc tttgctcact 878761 tttgaacagc tcttcgatac gtctcgggcg atatataaaa aacagaagaa gatattggag 878821 attgtgcttg agccttttga tattacagtc cttcaatatt tgctgatgtt taaaattcat 878881 caaagcggaa gcaccccgct aagcaagctg gcaatgtcgc ttgatcttaa gcctgcttct 878941 gtgacgcgga tgacagatat tctgtataag cgccaattga tgaatcgata tgacagtccg 879001 gatgaccgcc gtatcgtcat gattcagtta accgaagagg gggaagaact gatagaaaaa 879061 gccgctgtgc aatatgcaaa aatgggtgct ggcttgtacc aaaagcttga tacctcccag 879121 ctgcagtatt tgcgcaaact agccggaagt ttaacgaagc ttgctgaagg ctgttcagaa 879181 aaaagcggta attaaaaact tctcacatat tttcaccagc tttccgcaaa atgatagagg 879241 atgaaacgaa aggagaaaac aaaatgaaca gaggacgttt aattctgacc aacattatcg 879301 gtttgattgt tgttcttgca attatagctg gaggtgctta ctactattat caaagcacaa 879361 actacgtaaa aacagatgaa gcaaaagtag cgggcgatat ggctgctatt actgctccag 879421 cagcaggtaa agtatctgac tgggatctgg acgaaggaaa aacagtgaaa aaaggcgaca 879481 cagttgcaaa aatcaaaggt gaacaaactg ttgacgtaaa atccattatg gatggcacaa 879541 ttgtgaaaaa cgaagtgaaa aacggacaaa ccgtacaagc tggtacaaca attgcacaaa 879601 cgattgacat ggacaaccta tacatcacag caaatattaa agaaacagat attgcggata 879661 ttgaagtagg aaatagtgta gacgtagtag ttgacggaga ccctgatact acatttgacg 879721 gtactgtaga agaaattggt tatgcgacta actcaacttt tgatatgctt ccttctacaa 879781 attcaagcgg aaactacaca aaagtaacac aaaaagttcc tgtgaaaatt tcaatcaaaa 879841 acccatctga taaggtgctt cctggaatga atgcatctgt taaaatttct gagtaaaaca 879901 gatcagtcat caaaccatga aaggaggttg tcttagatgg ctacaggcaa agaaaaaaat 879961 gcaaaaaacc ctatgtcatt gctgattgtg ctaatggcgg gtttattttt ggcaattcta 880021 aaccaaacac tgcttaatgt tgcaatgccg cacttaatga ctgaatttgg cgtaagtgca 880081 acgacgattc agtggctgac aacaggttac atgcttgtta acggtgtatt gattccgtta 880141 tctgctttcc tgattacacg atttggccag cggagtctct ttctcgtcgc gatgttttgt 880201 tttacgctcg gtacgttagt ctgcggtatc gcacctaact tctctacaat gctgatcggc 880261 cgtttgattc aggccgtggg cggaggtatc ttgcagccgc tcgttatgac aaccattctg 880321 ttaattttcc cgcctgaaag cagggggaaa ggaatgggga ttttcgggct agcgatgatg 880381 tttgctccag cggtcggccc gactctttcc gggtggatta ttgagcatta tacatggcgc 880441 attatgtttt acggacttgt gccgatcggc gcaattgtta tcattgtggc tttcttcatc 880501 tttaaaaata tggtggagcc gcaaaaaatc aaactcgata ctcttggcgc aatcctctcg 880561 attgtcggat tcgcctcctt attatacgga gtcagtgaag ccggatctga cggctggacc 880621 gacccgattg tattgtctac agttattatc ggagccattg caattgttgc ttttgttgtt 880681 cagcaattgc gtcatgatga tccgatgctt gatttcagag tgtttaaata tgacattttc 880741 tcactctcga gtgtcattaa tatcattatt acagtggcac tttacactgg tatgttcctt 880801 ttaccgattt atctgcaaaa cctggtcggc tttacggcgc ttcaatccgg tctgcttctg 880861 cttccgggtg cgatcgttat gctgattatg tcaccgatct caggtatttt gttcgataaa 880921 ttcggaccga gaccgcttgc gattatcggg cttctcgtga cagtggtaac aacgtatcaa 880981 tacacgcaat tgacaattga tacaccatat acacacatca tgctgatcta ttcaattcgt 881041 gcatttggta tgtctctctt aatgatgcca gtcatgacag ccgggatgaa ccagcttcct 881101 gcccgtctga acagccacgg aacggcgatg agtaacacgc ttcgccaaat cagcggatca 881161 atcggaacaa gtttaattac gacgatttat acaaaccgga cgacattcca ttattcacaa 881221 attgcagata aaacaagcac ggcggacccg aacttcctcc atgcgttcca aaatgcagtt 881281 tcgaatttaa tggtgaatat gaatgtgtct tatgatacgg cgaaaacata tgtgtactca 881341 catatttata aacacgcatc actcgattcc aatgtcatgg ggataaatga tgcctttatg 881401 tgggcaacct tattctgtgt agcaggtttg attttaagta tcttcctgcg tgacgtcaga 881461 aaagataaat tgcgtaagaa gaaaaaagag gagctttcat tacttcctgc tccaaaagaa 881521 gctaaggaat cttaatctgt acagggaggt ttcctgaatg aaaatttatg tagtgtatga 881581 tagtgaaggc gaacatacta aagtgcttgc agaagcgatt gctgaaggcg cgagagaaaa 881641 cgacgcggct gaagtgttca tcgaccatgt agatcaggct gatatccgca agcttaaaga 881701 tatggatgcg attatttggg gatgcccagg gcatttcgga acaatcagct ccggtcttaa 881761 aacttggatc gacagacttg gctacttgtg ggctgaaggc gagctgatca acaaagtcgg 881821 tgctgtcttc tgcacaacgg caacaacaca cggcggcttg gaaatgacaa tgcacaattt 881881 aatcacgccg atgttccacc aaggcatgat tgttgtcgga ctgcctggca acgtgcctga 881941 aaacgcactt tatggctctt attacggagc aggtgtcact tgtccggtag acagtgatga 882001 gttaatgtct gaggaaggta ttcagcttgg acgcgcgttg ggaagacgtg tcagccaagt 882061 cacaggaaac ctaacagcag gacagtaagg agaggttgaa atggccatta ttatagcaat 882121 aattgctgct gtcattgtca ttgcggccct tattacattt aacgtccgca acgcctcacc 882181 tggacctgag aagcaagaag caaccgatag aatcgcacct ccagaagagg aaaaaaacga 882241 agcgcattac cctgctgaag caagggctgc cgagcatacg ccatccgttg tcaaaaacga 882301 ttctccaaaa gagaagcgtg acacaatggg tgatgatatt tacaggcagg cgctgcaaaa 882361 gtttaagcat tctgatgaag ttcatgcaga agaagaggtc actgaggaaa gtgacaaaat 882421 gcaggaccgc agctatcgtg atgcgctgct ctctatgaaa aataagaaaa agtaatgaaa 882481 aaggcaaatc cgtttactca tgcgggtttg ccttttttgc tgtttccatc aattatgttt 882541 ttatcaaata aatccatgga atatgttgta ttccaccttg atctagtgta ctatgttact 882601 catacaccga ggattttttc cgggaggtaa agacatgaat tcttttttag gtttattaaa 882661 gaaagatatc aagctttcaa gaatgtggct gctagtatgg atatgcggaa tcattttctt 882721 attgggaaca ggccatatta tagcttctcg cacgaaagaa cctctagtca tttttggttt 882781 ttttgttgca gttgcttttt ttctgctttt cttatctcct gtttttgttt tttatcacct 882841 tcgcaaggaa gggaaatcac agctttggct gtacaatcca aatggcggct tatggctgtt 882901 ttcttctaaa ttggcagcat ctttgctcta tcaatttgtg attcagttgg cattaacagc 882961 ctatggcata tggatgtatc atatgctctc tgtaaaaaat ctgctggagc atcaagttga 883021 tataacgagt acagtggctt tgctgaatat gtatgggctt atttcttcgt tagatatgtc 883081 agtaacagtc attgtgtttt ggactgtttt tcactctctc agaaattggc gcggaatgcg 883141 gtgggctgcg atggttctgt tggtcgcaat gtggttattc ttcgatgaat acatcataag 883201 ccctttggtt gaatctcaaa agcatttctg gcctgtaaca gtctattgca attttgattt 883261 ccacttccac aatgtttgga gattggaact aaaacctatc catctgtctg tgctagggtt 883321 tcctattgct atagtcatca cattcttgct gctcatcatg gcttcaaaac tgcttgatcg 883381 taaagtagag gtgtaaatat ggacaatcaa ttccaatcct cgaaaccgat ttatctgcag 883441 atcgctgatc agatctttta taggctggtc aggaaggagc tgctcccagg agacaagctt 883501 ccttcagtaa gagaaatggc gattcaaact aaagtaaatc ccaatacaat tcaaagaact 883561 tacagtgaga tggaaaggct gggtattgtg gagacaagaa gaggtcaagg gacgtttatt 883621 gcggaaaaag cagaaatcgt agacgagctg aaagacaagc tgacacgaga ggtgctggaa 883681 ggctttgtca agcaaatgaa agagctgggg ctaacgaaag aagaaatgtt agaagggatt 883741 aaaacattca cagagggagg ctaaaatgga aatcaagcta gaacatgtat caaaaaaata 883801 cggccgccat acggccgtca atgatgtgtc aatcacccta tcatccggac ggatttatgg 883861 cctgattgga ccgaacggca gcggcaagtc aacgaccctg aaaatgatgg ctggccttct 883921 gtttccgact tcaggatttg taaaagttga tgaagagcag gttacgagag aaatggtgcg 883981 tcaaacggct tatcttactg agcttgatat gttttatccg catttcactg ttaaagatat 884041 ggtgaatttt tatcagtcgc agtttcctga ttttcataca gaacaggttt ataagctatt 884101 gaatgagatg cagctgaatc cggaaaaaaa gatcaaaaag ctatcaaaag gaaatcgggg 884161 caggctgaaa atcgttcttg ctttagcgag acgggcagac gtcatcttgc ttgatgaacc 884221 tttttccggg cttgatccga tggtcaggga ttccatcgta aacagccttg tgtcgtacat 884281 tgattttgag cagcagattg tcgtgatcgc gacacatgaa attgatgaaa ttgagacttt 884341 gttagatgaa gtaatcatcc tcgccaatgg agaaaaagtt gcgcagcgtg aagtagaaga 884401 tattcgtgaa caggaaggca tgtctgtttt gcaatggttt aaatcaaaaa tggaagtttg 884461 ctagaaagag gaggaatatg atgaaaacag tgttggaatt gaaaaacgtg actaaaaaca 884521 tcagaggccg aacgatcatt gatgatctca gttttacgat tcgtgaaggc gaggtattcg 884581 gttttttagg accaaacgga gcggggaaaa cgacaaccat ccggatgatg gtggggttaa 884641 tgaagctgtc gaaaggtgat gtcctcattt gcggccaatc aattacgaaa gaatatgcca 884701 aggcgattaa gcatatcgga gcgatcgttg agaatcccga gctgtataaa tttttgagcg 884761 gatataaaaa tctccagcaa ttcgcaagga tggtcaaggg tgtcacgaag gaaaaaattg 884821 atgaagttgt tgaactggtc ggtttaacag acagaatcca cgacaaggtg aaaacatatt 884881 ctctggggat gagacagcgt cttggcttgg cacaatgcct tctgcacgat ccgaaagtgc 884941 tgattttgga tgaaccgaca aacggccttg atccggcggg gatcagagaa atcagagatc 885001 atttaaagaa gctgacccga gaaagaggaa tggctgtcat cgtttcaagc cacctgctgt 885061 cagaaatgga actgatgtgt gatcgaattg cgattctgca aaaaggaaag ctgatcgata 885121 ttcaaaatgt aaaagatgaa aacattgatg agaatgatac atatttcttc caggttgagc 885181 agccgagtga agccgctact gttttaaatc agtacgattt gctgagtaag acaaatggtg 885241 tagaaatcaa actggctaaa gaggaagtcc ctgcggttat tgaattgctg gtgatgcagc 885301 aaatccgtat ttatgaggtc aaggtcataa caaaatcatt agaggaccgt ttcttagaaa 885361 tgacaggtga aacaaaagag gaggttcagc atgcttaatt tgatttataa tgagtggctc 885421 aaaattttca gccgtgccgg aacatgggtg atgatcggaa ttctggggct gacaatggtt 885481 ggatttgcat ttttggcgaa tcatttttct gccggtgaat caaattccca ttggaaacaa 885541 gagcttcaag cacaaaacgc cgaattaaag aaagaaatca aagaagatcc ttcactgaaa 885601 gatgggtata aagaaacaat cacactcaat gactatcgca tcgagcataa tatccctagt 885661 gacacgggct atacggtatg gtcttatgta acggattcag caaactttac catccttacc 885721 ggtctgttta ctattatcat cgcggccgga attgtcgcga acgaatttaa ttggggaacg 885781 attaagctat taatgattcg gccgctcagt cgttttcaaa ttttgatgtc caaatatatt 885841 acagttctcc tgtttgggct cctgttgctg ttgattttat ttatcggttc tactttatta 885901 gggttgatct tcttcggaac gggtggtgaa accgccgcga atattcattt aatctataag 885961 gatggccatg tcattgagca aaacatgatg gggcatttgg ctacaacgta tctttctgaa 886021 tccgtctcgg ctttaatggt ggcgacgatg gcgtttatgc tgtctgcggt attcagaaac 886081 agctctcttg cggttggttt ttccatcttc ttgttggttg ccggtacgac tgcaactgca 886141 tttattgcag cgaaatttga ctgggcaaag tatatattgt ttgctaatgt cgacttgact 886201 cagtatgtgg atggcacacc gttaataaaa gggatgacta tgacgttttc tctcgtcatg 886261 ctggcgatct actttatcat cttcctgttg cttgctttcg gaatcttcat gaagcgggat 886321 attgcaaact aataaaaaaa gctgttttgc ttatgcaaaa cagctttttt gtcaaaataa 886381 aaactgcagg tttgcacctg cagtttttca tatcaattta tgcttacgct tctttagtaa 886441 cgttagcagc ttgtggtccg cggtttcctt caacgatttc aaaagaaaca gcttggcctt 886501 cttctaaagt tttgaagcct tcgccttgaa tagcagagaa atgaacgaat acatcgtctt 886561 gaccttctac ttcgatgaat ccgaaacctt tttcagagtt gaaccatttt actttacctt 886621 ctaacatgaa atttcctcct aaagcgatca taacgcttaa attcactatt cttgctctta 886681 acaaactttc aagacgaaaa ctcttacaaa actttcttct taaagatagt tcgaacaaaa 886741 ataattacct ttactctacc agtaatcttc agaaaaaaca actgcttatt gaaatttttt 886801 tcggaaaata ccatatttat ttttcaattt gatatttatt tacggaaatt catctgtttt 886861 ctcgatatgt gatcatacgt ttgccttagt attccttcat tttgggaaga taagtaatag 886921 gaattgacaa ccttattgga tatgagtaag gtaaaagtta atcaatatta caaatgacaa 886981 cgtttatcaa ctaagagagc gtatgatttt tatgtctgat attgcttgca tgctctaata 887041 catagatagg agtatggtca caatgaaaaa gtggcttata tgcagtttcg tccttgttct 887101 tctcgtttca tttactgcat gttcaccgtc tgcagaacat gaatcgataa aaatcgggat 887161 tgctgagtct gacggggcaa tatggaacta tattgctcaa aaggctgaag aggcagggct 887221 ggatattcag ctgatccctt tttctgatta tgcggagtct gatatcgcac ttgctaacaa 887281 agaaattgat gccaacgcct ttcaaaccat ttcatatttt cagtcgttca ctgaaaaata 887341 caaacttaat ttggcaccgc tcgggacgac atacataacg cccatgggca tttattcaaa 887401 acgatatgaa cgaatccgag atatatcgcg gggagctgtc gtttctgttc cggataaagc 887461 gttcgatttt ggcagggcgc ttacggtgct ccaggaagcg ggtttgctaa cgctgaaaaa 887521 cggatttaac ggaacaggtt cagttgatat gattaaagat aatccgagac acctgaaatt 887581 aaaagctgtc cggcaacagg atgcagtgag cggtgccgac gtgtttgtca tgaaaccatc 887641 agaagcaaaa aaagcgggct tgaacccgaa aaagcatacg ctaaagagcg gcggactcat 887701 gtctgaggaa gagatgaatt tgattgttgt cagagcggag gatcaagatc gggaagcgct 887761 gcaaaccatt cttgagcttt atcaagctga tgatacagcg gcatttatag aaaaagaata 887821 tcagggagat cttgtcccgg cttttctgcc tttgaaacgt ctttcagatt ggaagaatga 887881 attcgaacat tgaattcatt cttttttttc tgaaaaacac actctgttcc gtcccgtttc 887941 tttcgctttg taaagcattt gatcggcaag aatgggcaag gatcctggct gttccgtatt 888001 attggggtaa tgagcggccc ctagtgatat cgtaactgaa agctcgtcgc cgtttgttaa 888061 tacaatcggt gcatcactta cagtgctcct gatccgttca gcgatccggg ctgctttatc 888121 aagagaacag ttcggcagga gcacggcaaa ttcttcaccg ccgatccgag cggcaggatc 888181 agtatttcgg atggtctgct tcagacgtaa ccctagctct ttgagcacct gatctccttc 888241 atgatggcca tattggtcat tgatggtctt aaaatgatcg atatccatat aaatcagtgc 888301 aaattgaaaa tgcggggtat cggccgcctg ctgatacaga gcttttgtgg tttcttcaaa 888361 ttttcttcgg ttatacacgc ctgttaaaaa gtcaaagtgc gcctgaaact tatattgttt 888421 aaaaagaaga tgtgcatttg tttcatgatc aataatatat aaactgagca tgccgcccgc 888481 tattgatatg atccaaaaat acaaatgaag ttcgtatgaa tgtaaatcta taagaaaata 888541 aaaggaaaag gagatcaagc tatttgtgat tattaaaaga tagaaagcat gttttagttg 888601 aacttttttt cttctagaaa caatgagtga cggaatggca gcgatacaaa tgataataac 888661 cgagtatagt gcagatgtgt tcatcgtaat cagcaagcgg cctgcagtga tcatggccag 888721 ggccgttgcc gttgaaaccc agcctccata aagagcggca atcataatag ggatatttcg 888781 aagatcaata attgaatgct gataggtaaa tccaaaaacc atcagaataa ccccgagcaa 888841 accgcaggcc agtcctttaa cagcttgaaa ggatatgctg tcttttttat gtactagcct 888901 ttctttaaac aggtgggtga agagataatt aaatgtgatt aaaatggtca aatttacaaa 888961 cagttctttc agcaaatatt atcaccctta tataaggtac taaagatgga agggaaagaa 889021 aagaacaaaa aaggcattat ataaggtttt tttacttgaa ttgataagtt aaaataattc 889081 gcacttgacc catcggaatt agtgtaatat agtaaatgag aaaatttgaa gggagagttt 889141 acctgctttg gagactttac tggttgtatt acatgtattt attttatttt tacttatctt 889201 agggctcttt gttatgcaga aaaaacatgt ttccttctct aaacgtgtat ttactgcgct 889261 ggggctgggg attgtattcg gatttgcgct tcagctgatt tacggcccga cttcaaatat 889321 agtcattcaa acagccgact ggtttaatat tgccgggggc ggatatgtca aattgcttca 889381 gatggttgtc atgccgctcg tctttatttc gattctcggc gcctttacaa agctgaagct 889441 gacaaaaaat cttgggaaaa tcagcggttt gattatcggg attttagtag caacaacagc 889501 agttgctgca gctgtcggta tcgcgtccgc gctttcattt gatctgcagg cgattcaggt 889561 tgaccaagga agtacagagc tttcacgggg acaggagctt cagcagaaat cagaggatat 889621 gacagcgaaa acgctgccgc agcagattgt tgaactgctg cctggaaacc cgtttttaga 889681 ttttacggga gctagaccga cttcaacgat cgctgtcgtt atttttgccg ctttccttgg 889741 agtggcattc ctcggcgtaa aacacaaaca gccggaacag gcagaaacat ttaaaaaact 889801 ggttgatgcc gtttatgcca ttgtcatgcg tgttgtcaca ctcattttga gactgacgcc 889861 ttatggggtg ctggccatca tgacaaaaac aattgcaacg agtgatcttg acagcattct 889921 aaaactgggc atgttcgtga ttgcatcata tgccgcgtta atcactatgt ttatcattca 889981 tttgctgctg ctgacgttca gcggcttgaa tccggtgatt tatttgaaaa aagcggtgcc 890041 tgtacttgta tttgcattta cgtcaaggtc tagcgcaggt gctttaccgc tgaatattaa 890101 aacacagaga agcatgggtg taccggaggg aatcgcaaac tttgccggtt cgttcggtct 890161 ttcgatcggc caaaatggat gtgccggcat ttatcctgcg atgctggcga tgatgattgc 890221 tccgactgtc ggccaaaatc catttgaccc ggtgtttatt atcactgtta tcgcagtcgt 890281 tgccatcagc tccttcgggg ttgccggagt cggcggcgga gcgacattcg cggcgcttct 890341 tgttttatca tcattaaaca tgcctgtcgc gctcgccggt ttgttaatct caattgaacc 890401 gttaatcgac atggggcgta ctgctttgaa tgtcagcgga agcatgacat ccggtcttat 890461 tacaagtaag gtcacaaaag aaattgatca aggggcattt catgatcaat ccagagtgat 890521 tgaagctgaa gaagcgtaac atatgaaaac gtgtaatcca agaggattac acgttttttt 890581 aacggccagg ctctaagtcc tccagcattt ccatcatcgt gttgtcgtcc atgacattca 890641 ttgcgttttg ttcaaaatga atgggttcag cataatgcgg ctgtcttttt ttcgcggctg 890701 tctcagtttg cctagtttga gactgtgtat gctgatgctg tggttgctgc tgtccagcgt 890761 gctggtgctg acggccattt tgccgctggc tttgatgctg cgaacggtcc tggttatcac 890821 cgctgcttcc gctgcttccg ctaaatgctt gtttgaccat gtttcctaca ttagaagcat 890881 caaacgtgtt attttctgaa tttcgtctgt tcatttgtcc tgtgataaac ccgctgattc 890941 tttggcggat ctgaggtgat aatgcagtaa taagcatagt tgatcctatg atcaatgctg 891001 cggggctgat tcctcttcgc tggttgaaca acatgatccc tcctttgcag tgtattcata 891061 ttttccccct cgttagacaa attaaccgtt atatttcccg ggaaagcatt tcctccagat 891121 ttgcatgcat aattaaagcc agttagaaaa acctataagt aaagtgataa aggaggaatt 891181 cacatgtttg gaaaaaaaca agtccttgcg tctgtgcttc ttatcccttt gcttatgact 891241 ggctgcggtg tagccgacca aggtgagggc agacgtgata ataatgatgt aagaaacgta 891301 aattatcgaa atccggccaa tgacgatatg cggaatgtaa acaatcggga taacgttgac 891361 aacaatgtta atgataatgt caataacaat cgtgtaaatg acgataataa caacgaccga 891421 aaacttgagg ttgctgatga agcagctgat aaagtaacag acctaaaaga agtaaagcat 891481 gccgatatca ttgtggctgg aaatcaagcc tacgttgcag tcgttttaac caatggaaat 891541 aaaggtgcag tagaaaacaa tctgaagaaa aaaatagcca aaaaggtaag atctactgac 891601 aaaaacattg ataatgttta cgtttcagct aaccctgatt ttgtagagcg tatgcaagga 891661 tatggaaagc gtattcaaaa tggtgaccca atcgccggat tatttgatga atttacacaa 891721 actgtacagc gtgtattccc taacgctgaa taaatgaaag aagccgcaca atttgtgcgg 891781 ctttttcttt gcgttaatga cacactgcga actcaggctg catagagtaa aaataaaaag 891841 gtacaagacg gaccggctca gggagggaga cgtttgcggg atggcatagg aaagcgtgcg 891901 gcatccgctc tattcctgtg cggagtcctt gtgatgctgg ctgtaagctc agccatcgta 891961 tcaagcgcga tgtatatcct gtcttttcca ggtcaggcat ctggaataac aaaagaacaa 892021 gtgacgaagc acatgaagaa agagtcattc aaacaggccg atatttatta cacttctaag 892081 gaaaagtcct tactgccatt gacgaaagaa acgcttgaat atgcggtcag tattaatcag 892141 attatgattg gatattcgaa tcaaaagcct attgacatta ttttttttcc taatgaaaaa 892201 cagatggagg cttactccgg tttattggat gtagttggtt tttattctga acgggagcag 892261 ctgatcggat tgttgcctga agagaaaaag aaactgttag aaggggacga ggtagcggtt 892321 tatttgtacc agagattgtt gattcatgaa tactcgcacc atgcgtttca ccagaaattg 892381 aaggagcttg agacggatcc cgatgagttt ccgttatggt ttcatgaagg gttaagcgag 892441 tggattgcga actatgaatt gctcatagat ccgatcacgt tttctgtcgt gccctttgac 892501 cgtttgcaga ctgatcgaga ctggcaggaa gctagagccg aatatgacac tgatgtctat 892561 ttgcaaagct tttatatgat cgatgagctg acggacaaat acgggaaaga cattatttca 892621 gaaatgatta aggaaacggc aaaaaaaggg gactttgaaa aagggtttaa atcagcaaca 892681 aaggaaagtc ttgatcaatt tgaaaaagat tttaagaaaa aatttgaaaa aaacagtgcg 892741 gcattggata gtatctatcc aatgcctttg ttattagtga agtccttgct gacccattcc 892801 gccttgtgtc ggaggcattt gtccttgggc aggggcgaat gaatttcgca gctgttccat 892861 atcctgcgca tcaagctgag gaacctggta atagccgtgt ttgttttggt ataggaaaat 892921 ttcaaatgcc atttcaacat actcctgaat ttgcgcagac agtacgcgtc ttacggccgg 892981 atttgtcatt tccagagaag ccatcgtcag catagaagct tgtgctttaa tcgcgcaaag 893041 catttgtcgg ctgatgatgc tgtcatcaat atcattcatg gattgaacag gttttttagg 893101 ctgtgacggc tgcatgccgt aaacagtctg gttgtcttcc ttcatcatat aagttgctgt 893161 tttttgtgaa ggttcgcttc ctgttttgaa gcattctgca gttatattgt attgagatgt 893221 gatgaattga tgttgacgat caaggatgtt tagtaattct tgatccttac agaattgtct 893281 cagcatcata aactgatcaa gcacagtaag tgttccggaa agcacctcat gcatatcaaa 893341 catttcatgt ccgccgtggt ttttatgcgg tttgccagga atacctttgt tcatttggga 893401 ttgctgctgc tgattgaact gatccaaacc gaattcctcc ttttttttca gatcagctgt 893461 attttgtgtc agtctgccgt gtattatgca gaagcctgaa aggaattata tgctgtctgt 893521 cgaaatgata agcagacaaa atcgttgtca ttatgtgtat aagggaggaa atatgatgag 893581 gcgtattctg catattgtgt tgatcacggc attaatgttc ttaaatgtaa tgtacacgtt 893641 cgaagctgta aaggcagctg aaccgcaaca gcctatatcg attgagaagg caatacagca 893701 aaaagaagga caggcacttg tcgaaggata tgcagtcggc caggctgttt ccccgcagca 893761 ttataaactg acaagccctt tttcaaatga ttataatgtt gcgctggcag accgtaaaaa 893821 caaaacatcg cccgaacaca tccttcctgt gcaaatcccc tccgccttca gaagccaatt 893881 tgggctgcaa accaatccgc ttcttcttgg gaaaaagata acggttcaag gaaagcttga 893941 aaattacttt aacacgacag gacttaaaaa cgttcagtcg atgaacgtaa ccgatgacac 894001 aaaaactccg ccggctgaac agcaagtgac cataaatgaa gcacggggaa ggctgaatga 894061 agaagtaacg ataaaaggga tcattacagc tgatcaaaac gcaatcggag gcgggaagct 894121 gtcgaccttt ttgcaagatg aaaccggagg cattaacatt tattcgccat cccctgaaca 894181 atttcccgaa ttaaaagagg gtatggatgt cacggtgaca gggaaaatca cgtcttacca 894241 ggggctgaaa gaaatcgttc caaactcatc aggcatcaaa atcaaccagt caaatcaatc 894301 cctccccgcc cccaaacact taacaatcaa tgaacttatt aacggcagcc taggtgatca 894361 gtatgaagga cgccttgtga aactaaccgc ttttgtttcc tcaattccaa gttctcctgc 894421 cggcggcggt tacaatgtaa caatgattga tgacgaccat catgcaatga cgctccgggt 894481 tatgaatgaa acaggggtga taaacgagct tgatgagggc aaatggtatg aatttaccgg 894541 tgtgttaagc agataccaaa cctttcagct gcttccgcga aaatcggctg acctgaagct 894601 gcttgaagag cagcccgcac ctccgtctgc agagggagaa tatgaaggga ttgttgaccg 894661 ggtagttgac ggcgatacca ttcatcttaa atctccggtg cttggaacga caaaaatccg 894721 gtttgtaaat gtagatgcac ccgaaacata tcacacacca aaaaatgacg cagatgaaaa 894781 tcaattaaga tttggcaaaa aagcatctga ctatctaaaa acggttctgt ccccgggtga 894841 taaaattact gtcaaggtcg ggagtgaagc caaggacagc tatggcagat tgctcggaca 894901 agtcataacc gaatcaggtt caaacgtgaa cttagagctt gtaaaaaacg gctatgctcc 894961 gacgtatttt atttggccgg ttgacaatga agaggattat cagcaatttc aggccgcagt 895021 agccgctgca aaaaaagatc aaaaaggaat ttggaatgaa aacgatcccc tcatggaaat 895081 gccgtttgaa ttcagagcca gagagcaagg gaaaggcctg acaagatatg tgggggactc 895141 gtcgaataaa acatatgtgc agccagctga ctggaagaag atagctgtgg aaaacagaat 895201 tttcttcgcc tcagcaagtg aagcggagag cgcgggatat aaaaaaaggc aaacggcacc 895261 tcaagaacat gtgccgctta gaattctcag catgaatgat ttgcatggca aaatcgatca 895321 gcaatatgag cttgatcttg atggaaatgg aactgtagac ggcacgtttg gacgcatgga 895381 ttatgccgcc gcatatttaa aagaaaaaaa ggctgaaaag aaaaactcgc tgattgtgca 895441 cgcgggagat atgatcggcg gaagctctcc agtttcctct cttcttcagg atgaaccgac 895501 tgtagaactg atggaggaca tcggatttga tgtcggaacc gtgggaaacc acgaatttga 895561 tgaaggcacg gatgaacttc tgaggatctt aaatggcggt gatcatccga aaggcacaag 895621 cggatatgat ggacagaact ttccccttgt atgtgccaat tgtaaaatga aatcaactgg 895681 agagcccttt ttgccggctt acgacatcat taatgtggag ggcgtacccg ttgcttttat 895741 cggagttgtc acacagtcgg cagctggcat ggttatgcct gaaggaataa aaaatatcga 895801 gtttacagat gaagcaacag cggtgaataa ggcggccgaa gagctcaaga aaaaaggcgt 895861 gaaggccatc gcggttctcg cacatatgtc agctgaacaa aacggcaacg ccattaccgg 895921 tgagtctgct gatcttgcaa acaaaacaga ttctgaaatt gacgtgattt ttgccgcgca 895981 taatcatcag gttgttaacg gtgaagtgaa tggaaaactg attgttcaag cgtttgaata 896041 tggaaaagcg ataggtgtcg ttgatgtaga gatcgataaa acgacaaaag acattgtcaa 896101 aaagtccgcg gaaatcgtat atgttgatca aagtaaaatc gaaccggatg tcagcgcgtc 896161 agccatttta aagaaatacg aaacaattgc ggaaccgatt atcagcgagg tagtcggcga 896221 agccgctgtt gatatggaag gggggtattc aaatgacggc gatacacctc ttggaaacct 896281 gattgcggat ggtatgagag ctgccatgaa aacggatttt gcccttatga atggcggcgg 896341 catacgtgaa gcgctgaaga agggtccaat tacgtgggga gatctttaca atattcagcc 896401 gtttggaaat gtgttaacga agcttgagat taaaggaaaa gatttaagag agattatcaa 896461 tgcgcaaatc tcgccggttt ttgggcctga ctacagcatc agcgggttta cgtatacgtg 896521 ggataaagaa accggaaaag cagttgatat gaaaatggca gatggcaccg agatccagcc 896581 cgatgccaca tatacattga ccgtcaacaa ctttatggcg acggcgacag gagccaaata 896641 tcagccaatc ggactgctgg gaaaaaatcc ggtgacaggg cctgaggatt tggaagcgac 896701 agttgagtac gtgaagagtt ttgatgagcc aattgcgtat acaaaagagg gaagaattaa 896761 gcttgctgaa gccagtgata ttgaagaccc tgtaacagaa gacccgataa cggaagagcc 896821 tggagatgat ccggggacgg aggatccgat taaagaggat ccaaggccag gtgaagattt 896881 gcctgatata aaagaaactc cgggaacagc accggttcat cagcttccgc cttcagccat 896941 ttcgagattc aatgaaatac caatcaacaa cacaaaaacc gctgatactg ctaatagcat 897001 cagcacattg ccgttacaaa ccgagactgc ggaaagcggg tctgatcatc agcttccgga 897061 tacgtcagcg ggctactata actttatggt aatcggtgcg gcggtgacat tgtcaggaac 897121 ttatctatat gtcagaagaa aaaggagcgc ctccagaacg tgaaaaaagt tattccacta 897181 ttcatcattg ctgccggcct agtgatcgca ggctatggag gctttaaatt gatcgatacg 897241 aatacgaaaa cggaacagac attaaaagaa gcaaagctgg cggctaaaaa gccgcaggaa 897301 gcttcgggga cgaaaaatag cacagatcaa gcaaagaaca aagcatcatt taagcctgag 897361 accggccaag cgagcggcat tttagaaata ccgaaaatca atgcagagct tccgatcgtg 897421 gagggcaccg atgctgatga tttagaaaaa ggtgtcgggc attacaagga cagctattat 897481 cctgatgaaa acggacaaat tgtgctgtca gggcatcggg ataccgtgtt tcgccggacg 897541 ggagagctgg aaaaggggga tcagctccgt cttctcctgt catatggaga attcacatat 897601 gaaattgtaa aaacaaaaat tgtcgataag gatgacacat ctattatcac gctccagcat 897661 gaaaaggaag agctgattct gacgacctgc tatccgtttt catacgtcgg aaatgccccg 897721 aagcgctata ttatatatgg aaaacgagtg acttaaaaag ccgaggcagt gcctgcggct 897781 tttcttcatg aaaaatatgt gcggcaaagg tttttcatat cagcagggaa aggggcttca 897841 gcaactatga gctcgtctgt tatcgggtga accgcttgta ctttattggc gtgcagtgcc 897901 tgcctgttta gcagcttgct cccgcctccg taaagcgagt ctcctgtcaa cggatggccg 897961 aggctcgcca gatgaacacg gatttggtgt gttctgcctg tttccagctc taattcaacg 898021 agcgacagcc gttctttcgc attgctggcc attaccttga aatgagtgac ggctgtttgc 898081 ccgcctggtg aaacccggcg tcttgtcggg tgtgagcggt ctctgccgat cggtgaatta 898141 attgtccctt ttttcgtccg tagcttacct tcagcgatag cggtatacgt acgcttcagc 898201 gtctttttct ctaactgctg gtctaagatg gcgtgtgcca aacgatgctt ggcaaaaacg 898261 atagcgccag atgtatcctg atcaagacga tggacgtggc gcaccttaca tgtttcgcca 898321 tttatctgat aatgatacgc gatcaaatta gccagtgtgc cggtttgccc atcctcattc 898381 ggatgcgtcg cgatgccagc gggtttattg atgatgagca tatgattgtc ctcaaataaa 898441 atatcaagct cgccatactc cggaatgacc gaagatgctt cactttcctg aagatcaatg 898501 aacacgcggt ctcccttttt tacaatcata ttgtttaaga cggattcgtg attgaccttt 898561 atctgttgat gggacatcca gtcttgtatc actggtttag aagctttgag cgctgttttg 898621 agtacggaaa acagccattg gccgtcctgt ttttcattga tgaggatctc aagccctctg 898681 cctttttggt tcatgttaaa tggctccttt tcgaagcgga aggctgctgt ttctcatagg 898741 aaacacttac cttagctttc gcgttttttt ctgtgctatt cttgagtaag acttaggata 898801 ttcgatggca agaaaggtga ttgacgtgag aattgtgaac gcagcaactg cagaacagga 898861 gagctttatc aaggagctgt ctatggagct gatccatgat gtatttcctc tttatttctc 898921 cgaactggac attcagcgct ttaaaaagaa aggcgttctg tctttaaata accattatta 898981 ccaaggaaca ttaaaagaag catttcaaat tatggcttgt ctgcaaatga tacatattat 899041 cctgaccaag ccttcgccgc actctgattt gagtgatcag gcgatttttg aaaaaaacag 899101 caagatgctg aatgattttg ggatttattt tccgtttgct ttttctgact ttcaaaagaa 899161 gactaacaaa gcctttttcg gtcaaagaag gctgatataa tcatgcggca agggcttttc 899221 tatttttaga aaagctcttt ttgtatcaga gaaatcatat cataaaacct ttcctctaac 899281 tcccttttta aacggctcgt gtctgaacat actaatgatt gaaaggggtg ctgacaatga 899341 gttcagttaa agatacaatg acaacgcagg tggcaaccgt ttctccgaat caaacgattc 899401 aggaagcggc ttctctaatg aaacagcata acgtcggggc gatccccgtt gtagagcaag 899461 gtgttttaaa aggaatgctg actgaccgtg acattgcatt aagaactaca gctcagggcc 899521 gtgatggcca gacacccgtt tcagaagtga tgtcaacaga actcgtatca ggaaacccta 899581 atatgagtct ggaagacgcg tcgcagctga tggcccagca ccaaatccgc cgccttccta 899641 ttgtagatca aaacaatcta gtcgggatcg ttgcgcttgg agacctggca gtcaatcaga 899701 tgtcgaacga gtctgcggga tcagcgctga caaacatttc tcaccaaaac attcattaat 899761 aagaaagagc ttgcagtgtg caggctcttt cttcacataa aaccttactt tttgaaagca 899821 gacttgtttc ggggtatagt gagtgtatac atatgtctca attcgtacta aaggagttgt 899881 acccagtgat taaagcgtta atttttgatt ttgacgggct tattctagat acagaaacac 899941 acgaatatga ggttcttcag gaaatatttg aagagcacgg ctcagtgctg ccgctatctg 900001 tctggggaaa ggtcatcgga actgctgcgg gtttccggcc ttttgaatat ttagaagagc 900061 agatcgggaa aaagctgaac catgaagagc tcacacaatt gagaagagag cggtttgcca 900121 aacgcatgga atcagaaaaa gcgagacctg gtgtcgaagc gtatttgaat gcggcaaagg 900181 atttaggctt aaaaataggc cttgcctcca gctctgatta taaatgggtg tccggccatt 900241 tgaagcaaat cggcctgttt gatgattttg aagttattca aacggcggat gatgtggaag 900301 aggtgaagcc gaatcctgaa ctctatttat tggcggcaaa gaacctgggg gtatcgccag 900361 cggaatgtct cgcgtttgag gattctgtca atggttcgat tgctgcgaaa cgtgcaggca 900421 tgaagtgtgt cattgtcccg aataaagtaa cgggtacctt gatgtttgaa gactatgatc 900481 acaggcttga atcaatggcg gagatggagc tcgccctatt gcttgatcat ctgaactcac 900541 aaaactagaa aggagcgagt aggttgtctg agaaattaga tttgacccgg tttgaaaaga 900601 aaatggttat ccgcaatatc gaagagaaag acatcgacaa gattatcgat cttcaaaagg 900661 actgctttcc aggaatggag ccttggaagc gggagcattt aatcagccat ttggagcatt 900721 ttccggaagg acagttttgt gcagaattcg aaggtgaaat tatcggttcg tgctcaagtc 900781 tcctgattaa ctttgatgaa tatgatgacc gccatacgtg gcaggacatt acagatgacg 900841 gttatatcac caaccataat cctgacggct tgaatatgta cggaattgaa gtcatggtgc 900901 acccgaaata cagacgaatg aagatcggcc accgtttgta cgaggcgaga aaggacttag 900961 ccagacgctt aaacctgaaa agcatcatca taggcggacg gattccaaac tatcacaaat 901021 atgcagagga aatgacagcg agagagtatg ttgaacaggt gacacgccac caaatttacg 901081 atccggttct ttcttttcag ctgatgaacg gctttaccct tatgcgaatt aacccgaact 901141 atctcccgga tgatacagct tcgatcaagt atgcgacgct gatggaatgg aataatgtcg 901201 attatctacc gcagcagaca aaacgctatt ataaatcggc gttccctgtt agaatttgtg 901261 tgatccaata cgaaatgaag aaaatttatt cctttgagga atttgcgaat caagtagaat 901321 actatgtcga tgttgcttcc gacgcaagat ctgattttgc ggtgttcccg gaaattttca 901381 caacccagct gatgtccttc cttgaggaac ggtcaccgag cttggcggtg cagagaatta 901441 ccgagtatac agaagattac atcagcctgt ttactgactt ggctgtgaag tataacgtca 901501 acattatcgg cggatctcat ttcgtcgaag aggaaggcaa gatctataat atcgcttacc 901561 tgttcagacg ggacggaacg atcgagaagc aatacaaact ccatattacg ccgaatgaac 901621 gcaaatggtg ggggatcagc gcaggagacc aagttcgcgt gtttgatacg gactgcggga 901681 aaatcgcgat ccagatctgt tatgacattg aatttcctga gcttgcccgg attgcggctg 901741 ataaaggagc caaaatcatc tttacgccat tttgtacaga agaccgtcaa ggctatctgc 901801 gtgtcagata ctgttcgcag gctagagcgg ttgaaaatca aatttatacg gttatctctg 901861 gaacggtcgg aaaccttccg caaacggaaa acatggatat ccaatacgcc cagtcaggca 901921 tctttgcccc gtctgatttt gaattcgccc gagacggcat tgtcggcgaa acaaacccga 901981 atattgaaat ggtcgtcatc ggcgatgttg acctggaaat tctcagaaga cagcgccaaa 902041 acggtacagt gcgccagcta aaagacagac gacgtgatat ttatcatatt caatataaaa 902101 aataattccc aaaaaacccg cctgaattgg cgggtttttt taaacaaaag cggaattgtt 902161 taggtgcttt ctttaaaata aaagtaaatt gtatagtgga tgtgccttat ggagtttctg 902221 tattttcgcc atttcctata tcatacagaa aacggctagg cttcacattg ctattgcaat 902281 ggctgtccaa gttgtttcga gtgcgacctt tatcagtacg atgctgagca ttgtcacttt 902341 gcctgttttg ctttggaagc tgcatcctct ttcttcttga gaaaggggat gttttattat 902401 ttacgcggtt tattgactct gacccggtct ggctttatat tgaaggcagg gaaatcatca 902461 ccaagacatc acataaagag aaggtctgtt tcaattgaat tggcattata gggaacgcta 902521 atgaaatgga gatgatgggg atggaaaaca ttcagcaaaa tcagggatta aagcaaaaag 902581 atgagcaatt tgtgtggcat gccatgaagg gagcgcatca agcggacagc ctgatagccc 902641 agaaggccga aggggcctgg gtaaccgaca cagacggacg ccgctatttg gatgcgatgt 902701 ccggtttgtg gtgcgtcaac attggttacg gcagaaagga gcttgcggag gctgcctatg 902761 agcaactaaa ggagctgcct tactacccgt taacgcaaag tcacgcaccc gcaattcaac 902821 tggcggaaaa gctgaatgaa tggcttggcg gcgattatgt tatttttttt tccaacagcg 902881 gatcggaagc aaacgaaact gcttttaaaa ttgcccgcca gtaccatctg caaaacggcg 902941 accacagccg ttataaattc atctcaagat atcgggcata ccacggcaat acattgggag 903001 cgctctcagc taccggacag gcgcagcgga aatataaata cgagcctttg agccaagggt 903061 tcctgcatgc agctccgcca gatatatacc ggaatcctga tgatgcagac acgcttgaaa 903121 gcgcaaatga aatcgaccgc atcatgacat gggaattaag cgaaacgatt gccggggtca 903181 ttatggagcc catcattaca ggcggaggca tcctaatgcc gccggacgga tatatgaaga 903241 aggtggagga catttgccgg cgccacggag cccttttgat ttgcgatgaa gtgatctgcg 903301 ggtttggacg gacaggtgag ccgttcgggt ttatgcacta cggtgtgaag cctgatatca 903361 ttacgatggc aaagggaatc acaagcgcgt atctgccatt gtcagcgact gctgtgaaac 903421 gggacatttt cgaagcgtat cagggggaag ctccttatga ccgtttccgc cacgtgaaca 903481 cgttcggcgg aagcccggct gcctgtgctt tggcgttgaa aaacctgcaa attatggagg 903541 acgaacagct gattcagcga tcccgtgatc ttggagcaaa gcttttaggt gagcttcaag 903601 ctctgagaga acacccggca gtcggggatg ttagaggaaa agggctgctg atcggaatcg 903661 aactcgtcaa agacaaattg actaaagagc cggctgatgc cgccaaagta aaccaagtgg 903721 ttgcggcgtg caaagaaaaa gggctgatca tcggcaaaaa cggcgataca gtcgccggct 903781 acaacaatgt catccagctt gcgccgccat tttgcctgac agaagaggac ctttccttta 903841 tcgtgaaaac ggtgaaagaa agctttcaaa cgatataata taaaagtgaa ttattaaagg 903901 agcacatgat gagttttcac aaccagccga tcttaccggc tattcgcaat atgaagcaat 903961 ttgatgagtt tttgaacagt tcattctctt acggtgttat tcttgatatt catctcggcc 904021 agctgaaggg cgtgatcaaa gaagcgcaaa agcacggaaa gaacatgatg gtgcacgtcg 904081 atctcattca agggattaag catgacgaat acggtgcgga atttatatgt caggatatca 904141 agcccgctgg gattatttcc acaagatcga atgtgattgc caaagcgaag cagaagaaaa 904201 tttatgccat tcagcgcctg tttttgcttg atacaagcgc gatggagaaa agcatggagt 904261 ttatcggcaa gcataagcct gacttcatcg aagtgcttcc cggcatcgtt ccgtcactca 904321 ttcaggaaat aaaagagaaa acagggattc ccatctttgc cgggggtttc atccgtacgg 904381 aagaggatgt agagcaggca ttgaaagcgg gggctgtagc tgtcacaaca tctaatacca 904441 aattgtggaa aaaatatgaa aactttttga cggaaagtga ttgacaccgc tttcatgcac 904501 tgatacaatt gcactaggtt aatacattgt gatggagaac tcggagacca cagcagctct 904561 ttacggcaaa tgtttatgca cccgtaaagc ggtttgttgt ggttttttta ttctcttctt 904621 ctctatcatg ctttttaatc gtgactttag gaggaatgtg ctatgacagc attttgggga 904681 gaagtcatcg gtacgatgct gcttatcatt tttggtgcag gtgtttgtgc aggtgtcaat 904741 ttaaagaaat cgctttcatt ccagtctggc tggattgttg ttgtatttgg atggggattg 904801 ggtgttgcca tggcggcata cgcggttggc ggcatcagcg gtgcccattt gaatccggcg 904861 ctaacgatag cgcttgcatt tgtaggagat tttccttgga aagaggttcc ggtttatatt 904921 gcggcgcaaa tgatcggagc gatcatcggt gcggtgatta tttatctgca ttacctcccg 904981 cactggaagt caacggatga tcccgctgcc aagctgggtg ttttctcaac agggcccagc 905041 attccgcata catttgcaaa cgttttaagc gaagtgattg ggacatttgt ccttgtactt 905101 ggaatcttgg ccataggtgc aaatcaattt acagaaggac ttaatccttt aatcgtcggt 905161 ttcctcattg tagcaatcgg tatttctctg ggaggcacca ccggctatgc tatcaatcct 905221 gcacgtgact taggtccgcg gatcgcccac gcttttcttc cgattccggg gaagggctca 905281 tcaaactgga aatacgcatg ggttccggta gtcggcccga ttttaggcgg atcattcggc 905341 ggtgtatttt acaacgctgc atttaaaggg cacatcacaa gcagcttctg gattgtaagc 905401 gttatattgg ttgtggtatt gttaggactc tatgtttata cgaaatcaca ttctgctaaa 905461 acattatcaa attctaaata tatttaatca aaggggagac atcttatgga aacgtacatt 905521 ttatccttag atcaggggac gacaagttca agagcgattc tgtttaataa agaaggcaaa 905581 attgtccact ctgctcaaaa ggaatttaca caatacttcc cgcatcctgg ctgggttgag 905641 cataatgcca atgaaatttg gggctctgtc ctcgcggtta tcgcctcagt catctctgaa 905701 tcaggaatca gcgcttctca aattgccggc atcggcatca cgaaccagcg cgagacgacg 905761 gttgtgtggg ataaagatac aggaagtcct gtctataatg caatcgtttg gcagtccaga 905821 cagacgtccg gcatttgtga ggaacttcgt gaaaaaggat ataatgataa attcagagaa 905881 aaaacagggc ttttaatcga tccttacttc tccggcacga aggtgaagtg gattttagac 905941 aatgtggaag gcgcaagaga aaaagcggaa aaaggcgagc tgctgtttgg aacgattgat 906001 acgtggctca tttggaaaat gtcaggcgga aaagcgcatg tgaccgatta ctccaatgcc 906061 tcaagaacac tgatgtttaa tatttacgat ttaaaatggg acgatgaact gctcgacatt 906121 ctaggcgtac cgaaatccat gctccctgaa gtgaagccgt cctctcatgt gtatgcggag 906181 actgttgatt atcacttctt cggaaaaaat atcccgattg ctggagcggc aggcgaccag 906241 cagtccgcat tgttcggcca ggcatgcttt gaagaaggca tggggaaaaa cacttacggc 906301 acaggatgtt tcatgctgat gaataccggg gaaaaagcaa ttaagtccga acatgggctt 906361 ttgacaacaa tcgcttgggg cattgacgga aaagtgaact atgcgttaga agggagcatt 906421 tttgtcgcag gctctgccat ccagtggctt agagacggtt tgagaatgtt ccaggattca 906481 tcgctaagcg aatcttatgc agaaaaagtg gattcaactg acggcgtgta tgttgttcca 906541 gcatttgtcg gactgggaac gccttactgg gacagcgatg tgcgcggttc ggttttcggc 906601 ctgacaagag ggacaacaaa agagcacttt atccgtgcga cactggagtc attggcttat 906661 cagaccaaag atgtgcttga cgcaatggaa gcagattcaa acatttcatt aaagacgctc 906721 cgtgtagacg gaggagctgt aaaaaacaat ttcctaatgc agttccaagg agacctgttg 906781 aatgttcctg tggagcgccc ggaaattaat gaaacgactg cacttggcgc ggcttatttg 906841 gcgggtatcg ctgtgggatt ctggaaggac cgttctgaaa tcgcgaacca gtggaatctg 906901 gataaacggt ttgagcctga attggaagaa gaaaaacgaa atgagctgta taaaggctgg 906961 caaaaagccg tgaaagcagc tatggctttt aaataaagta atactatggt ataatggtta 907021 caagttaata agaacggtcc tgagatgagg agagaccaca gcaccaaagt gtaagcatgc 907081 actttggctg ttgtggtctc tttttctatt taccgtgaca acaaggagga aacgtaatga 907141 tgaatcatca attttcaagt cttgaaagag atcgcatgct gacagacatg acgaaaaaaa 907201 catatgacct atttattatc ggaggaggaa ttacaggagc cggaacagct cttgacgcgg 907261 catcaagggg aatgaaggtc gcactaagcg aaatgcagga ctttgcggcg ggaacatcaa 907321 gccgatcaac gaagctggta catggcggct tgcgctattt aaaacaattt gaagtgaaaa 907381 tggtcgctga ggtaggaaaa gagcgggcga ttgtgtatga aaacggcccg catgtcacta 907441 caccggaatg gatgctgctt ccgtttcata aaggcggcac attcggttca tttacaacat 907501 ctattgggtt aagggtttat gacttccttg caggtgtgaa aaagtcagaa cgaagaagca 907561 tgctttcagc aaaagaaacg ctgcaaaaag agcctttggt gaaaaaagac ggcttaaaag 907621 gcggcgggta ctatgtggaa taccgcactg acgatgcgag actgaccatc gaagtcatga 907681 aggaagcggt taaattcggg gcagagcctg tgaattactc caaagtgaag gagcttcttt 907741 acgaaaaagg caaagccgtc ggcgtattaa ttgaagatgt gctgacaaag aaagaatata 907801 aagtgtatgc gaaaaaaatt gtcaatgcta caggcccttg ggtcgatcag ctcagagaaa 907861 aagaccattc gaaaaacgga aagcatttgc agcatacaaa aggcattcac cttgtatttg 907921 accagtctgt ctttccgctg aaacaggctg tatatttcga tacacctgat ggccggatgg 907981 tatttgcgat tcctcgtgaa ggcaaaacat acgtgggaac aacagacact gtttacaaag 908041 aggcgctgga gcatccgcgg atgacaacgg aggatcgtga ttatgtcatc aaatcaatca 908101 attacatgtt cccggaactg aatatcactg cgaatgacat cgaatccagc tgggcggggc 908161 tgcgtccgct gattcatgaa gaaggcaaag atccttctga aatttcacgg aaagacgaga 908221 tttggacatc tgactcaggc ctgatcacca ttgccggcgg aaaactgact ggatacagaa 908281 aaatggcgga gcacatcgtt gatcttgtcc gtgatcgctt aaaagaagag ggcgaaaagg 908341 attttggacc atgtaaaacg aaaaacatgc caatctctgg cgggcacgtc ggcggttcga 908401 aaaatcttat gtccttcgtt accgcgaaaa caaaagaagg aattgcagcc ggtttatcag 908461 aaaaagacgc aaaacagctt gcgatcagat acggctctaa cgtagatcgc gtctttgacc 908521 gggtagaagc gctgaaagat gaggccgcga aacgcaacat tccggttcat attcttgctg 908581 aggcagaata cagtatagaa gaagagatga ctgcaacccc tgctgacttc tttgtccgca 908641 gaacgggacg tttatttttt gatatcaatt gggtaagaac atataaagat gccgttattg 908701 attttatgag cgagcgattc caatgggatg agcaggcgaa aaacaaacat acagaaaacc 908761 tcaacaagct tttacacgat gcggtcgtac cgcttgagca ataaatcata acgggctgtc 908821 tgcagcccgt tatttctttt tacgtgccga aagggggaga tctcaggtta tcaagtgaca 908881 gaggcacccg cttcatataa aataatggca taagctgata cataggagga cgaatatgac 908941 ttggagaaag agctatgaac gctggaaaca gacagaacat ttagatctgg aattaaaaga 909001 gcgccttatt gaattagagg gagatgaaca ggcccttgag gactgtttct ataaagacct 909061 tgaattcggt accggcggaa tgcgcgggga aatcggcgcc gggacaaatc ggatgaatat 909121 ttacactgtg cgcaaagcat cggccgggtt tgcggcatac atctcgaagc aaggtgagga 909181 agcgaaaaaa cggggcgttg tcattgctta tgattcccgc cataagtctc cggagttcgc 909241 gatggaagcg gcaaaaacac ttgcgacaca aggcatccaa acatacgtgt ttgatgagct 909301 tcgcccgacg ccagagctgt cattcgctgt tagacagctg aacgcttatg gtggaattgt 909361 ggtaacggca agccataacc cgcctgaata taacggctac aaagtatacg gggatgatgg 909421 cggccagctg cctccaaagg aagcggacat cgtcattgag caggtaaacg cgattgaaaa 909481 tgagctgacg atcacagtgg acgaagaaaa taagttaaaa gaaaaaggct taatcaaaat 909541 catcggtgaa gatattgata aagtttatac agaaaaactg acgtccattt ctgtacatcc 909601 tgaattatcg gaagaagtag atgtaaaggt tgttttcaca ccgctgcatg gaactgcaaa 909661 taaaccggtc agacgcggtc ttgaagcact cggctacaaa aatgtaacgg ttgtcaaaga 909721 acaggaactg ccggattcaa acttctccac tgttacatcg ccgaacccgg aagagcatgc 909781 ggcattcgaa tatgccatta agcttgggga ggagcagaat gcagatattc tcatcgcgac 909841 agatcctgat gctgaccgcc tcggcatcgc ggtgaaaaac gatcaaggca aatatacagt 909901 gctgacagga aaccaaaccg gagcgttgct gcttcattac ctgctttctg aaaagaaaaa 909961 acaaggcatc ctgcctgata acggtgttgt tctcaaaacg atcgtcacaa gcgaaatcgg 910021 ccgtgctgta gcttcttcat tcggccttga tacgattgat acgctgacag gctttaagtt 910081 tatcggtgaa aagattaagg aatacgaagc atcaggccag tataccttcc aattcggtta 910141 tgaagagagc tacggttatt taatcgggga ttttgcccgc gataaggacg ccattcaggc 910201 tgcgcttttg gcagttgaag tttgcgcgtt ctataaaaaa cagggaatgt cattgtatga 910261 ggcgctcatc aatctcttta acgaatatgg tttttatcgt gaagggctga aatccctgac 910321 gctgaaaggc aaacaaggag cagagcaaat tgaagcgatt cttgcttcct tcagacaaaa 910381 tccgccgcag aaaatggcgg gcaaacaggt tgtcacagca gaagattacg ctgtaagcaa 910441 acggacgctt ctgactgaaa gcaaagaaga agccatcgac ttgccaaaat caaatgtatt 910501 gaaatacttc ctggaagacg ggtcttggtt ctgtctccgt ccttctggaa ctgagccgaa 910561 ggttaaattt tatttcgccg taaaagggtc atctttggaa gacagtgaaa agcgacttgc 910621 cgtcctttct gaagatgtaa tgaagacggt ggatgaaatt gttgagtcaa cagcaaaata 910681 attcaagtat gagctgggtc attgtaaatg atccggcttt ttctttttct catccaaaag 910741 tctgaaagaa aatcatccta caagtgaagc aatgaaatac aaaaaactgg tataatctta 910801 aatacaagat caatgccgga gtgagaaacg tgagcaaaac gaggatggaa aaattaaaaa 910861 cgctgaaaac gattgcggaa accttaaatc aagggcacga tatcaaagca acactggatg 910921 aggttttaaa agagttgctg agtctgacaa accttcaatc cggatggatt tttctgatcg 910981 aagaagatgg gtcttatacg ttagcggccg acgcttatct gcccccggct ttaagccgca 911041 aggaaaaagt gctgatgtgc gaaggggagt gttactgcct gacgaaattc aataacggag 911101 ggcttagaaa agctgcaaat atcatgaact gcaaacgcat cgaatcagca gaaaacctgc 911161 attgttttga cacagaaggg attacgcatc atgcaactgt gcctttagaa gacggggaca 911221 gaagattcgg attgttaaat gtagcggcgg ccggaaaaac catgtttgat gaggaagagc 911281 tgcatttact cgagtctgtc gcctttcaga tcggaacggc aatccagcgt atgaggcttt 911341 ctgaatatca acaaaaaaat gctcttttaa tggagcgtaa ccgcctcgct caggagcttc 911401 acgattcagt caatcaaatg ctgttttccg tcagtttaac tgccaaagct gcgaagacac 911461 taacaaaaga tgaaaattta cagcagatga ttgatttcat ccaaaaccta tcacaggacg 911521 cgctcgcaga aatgaaagcg ttaatttggc agcttcgccc cggaggattg gaaaaagggc 911581 tggctgaagc cattaaaagc tatggtgcgc tcattggatt gaagatcatt tttacacaaa 911641 aaggctgtcc tgttctgact gatgagcagg agcatatgct atggcgtgtc gtacaggaag 911701 ctttaaataa ctgcaaaaag catgccggaa cggatacggc gtatgttagt ctgactgctt 911761 ctttgtgcca tgcggagctg gatatcatcg atcatggggc aggatttcgc tatgaagcgc 911821 atgccggtct gccttcactt ggcataaaag gtatgaaaga gcgagcggaa aaagccggag 911881 ctaagttttg gattgagtca gcgcttggaa ctggaacaaa gctgtccatc aggcttccgc 911941 taaaaagccg aaaaggaggg gcggtatgaa aattgtcatt gctgatgatc atcatgttgt 912001 cagaaagggt ctgcgttttt tctttgccac ccaggatgat attgaagtcg tcggagaagc 912061 tgcaactgga ttagaagccc tccgtgtcat cgaagagaca aagccggatc ttgtgctaat 912121 ggatttgtct atgcccgaga tggacggcat tcaagccatt aaaaaagcaa tacagcaatt 912181 tccggatacg aatatcattg tgctgacgag ctactctgat caggagcacg tcatccccgc 912241 gcttcaggca ggcgcgaagg cgtatcaatt aaaggatacg gagcccgagg aattggtgaa 912301 aacacgacaa gtgcatggtg gcgaatacaa gctttctaca gctattatgc cccatgtgct 912361 gacacatatg aaaaatcagc acgacccgga aaaagaaaaa tactatcaat taactagaag 912421 ggaaaaagac gttctgactg aaatagcgaa cgggaaaagc aataaagaaa tcgcagcagc 912481 cttgtttatt tcagaaaaaa cagtaaaaac ccatgtatcg aatcttttag caaaacttga 912541 agtggccgat cgcacgcaag cagcgctttt cgcagtgaaa tataacctga atggagagat 912601 ctcaaaatga acatgttagt cataaatggc acgccaagaa aacatggcag aacaagaatt 912661 gcagcatcct atattgcagc tctgtatcac acggatttga ttgatctaag cgagtttgta 912721 ttgcccgttt ttaacggtga agcggaacaa tctgaactgt tgaaagtaca ggagcttaag 912781 caacgcgtta cgaaagcgga tgcgattgta ttattatcgc ctgaatatca cagcggcatg 912841 agcggcgctt taaaaaatgc cttggatttt ctaagcagcg aacaattcaa atataagccc 912901 gttgcattat tggcagtagc gggaggcgga aaaggcggca tcaatgcgct gaacaatatg 912961 agaactgtga tgcggggtgt ctacgccaat gtcattccga agcagctggt gcttgatccg 913021 gtgcatattg atgttgaaaa tgctacagtg gctgaaaaca ttaaggaaag cataaaagag 913081 cttgtcgaag aactcagcat gttcgcaaaa gcaggaaatc ccggcgtcta aacgccggga 913141 tttgtttatg tgagaagggc tatttgatct tcataagtca gctctgtggc atgatcaata 913201 tatcggagaa gggaatacag catcttttct aaaacggcgt aatcctgttc aaaatgatac 913261 gcatgcagaa aatgctcaat tcgttttgat aacaaatcgt cctctgtacg caccattaaa 913321 attaataaat tatcccattg agaacgatgg gtgtaataaa gcgctttatc gtaatcggca 913381 taatccatga atcgcttctc ctttcttggg tgagaagttc atgattagtt tatgccgcat 913441 cctctgttat tgacggggca aaacttgccg tctgcgtcag taaaggggta gcaatatgag 913501 ggagacataa aatcaaaatg cctgaatgaa gatatcgctt ttggtaaacc tatgagggaa 913561 tatattctgg gtacaggaga ctgaaaaaat gaaatccctg ccgtatacca tcgcacttct 913621 tttttgcgga ttgattatcg tgtcaatggc tgcaaaaggt cattcaacgg acacagacga 913681 gtccgttcaa aagtgggaac agcttgcctg gagcaaaatt caggatgaat ataagggcgc 913741 ttcattttct gattatgctt atatggggcg tacagaggtg aatgatcagc agactaaaga 913801 tgtctttcgg gtgacagtca gacagaaaga tgacactttt tctgttcggg ccgaagtcta 913861 ttttcatccg gtgacaaatc atatgatcag catcaacgtc tttaggctct aataaaaaac 913921 tgtacagccg ttaaggccgc acagtttctg tttttagaaa tatcgttttg caccgagata 913981 gcgctgtttc cagtaagagt tgttcatatt ggaaatgaca actccggaat cgttggcatt 914041 tatgaattcc ccgttgccta ggtaaattcc gacgtgggaa gggccggctt tatatgttga 914101 aaagaaaacg aaatctccga cagcaggctg gctaactgat ttcattgtgt tccaatatcc 914161 cgctgccgtt aatctagata cggatgtgac tttgttcagt acatagtaaa tgaatccgct 914221 gcagtcaaac ccggacggtg tcgtgcctcc ccagcgatac ggaaccccaa gctgcgcttt 914281 agcggccgaa atcattgtgt taatcttcgc actcgttgag ctggtggtgt ttgaagaacc 914341 ggatgaagac gatgatgaag cttttccgga aatgaccagc ttttggccaa cctgcaagac 914401 atccgttttt aaattgtttt tctcacgaat ctgctgagct gttacattaa atttttgagc 914461 aatcacccat aaggaatcac cgcttttcac cgtgtatgta gtcgtcgtgc cggagcttgc 914521 atttgacgaa gaagacgacg atgatgaaga gcctgaagat gctttacctg tcagcttcaa 914581 tacttgtcca acgtaaagca catctgattt cagattgttg atatttcgga tttgctgtac 914641 agtcaggtta tagttgtttg cgattttcca aagtgaatca ccgcttttaa cggtatattt 914701 agttgttgct gaagtttggt tcgatttgga tgaattgtct ttagaagacg tatcagagcc 914761 gcttgatttt gttttcaaca cctgattcac gtaaatggtg tctgatttta agttgttcaa 914821 gaccttcaat tcagcgatgg acatattgac tttgtttgca attttccaaa gtgaatctcc 914881 aagctgcacc ttatatgttc ccgtagaaga tgaagaactt gaactcttat tagaactgct 914941 ttttgaactg gagcttgaac tcttattaga gttgcttttt ttactggaac tagagcttga 915001 agaaacagta ccggacacct ttaatttctg cccagcacga attaaatcgc tgcttagtcc 915061 gtttaatttt ttcagttcct gcaccgtcat tttaaactca tttgcgatca gccaaagtga 915121 atctccgctt ttcactgtgt aaacagaact tccgctcttc ttggttgttg agcttgaagt 915181 agatgaagaa gtgctggatt tgctgcctgg aatagtaagc gtctggccga tcgacagaac 915241 agtagtcgaa agatgattgg cggatgtgag ggccgccaca cttgtgttat aggtttgggc 915301 cagtttccat aaagaatctc cgcttttgac cttaatcgtt gctgcttcag ctggtgtcac 915361 tactaaagtt gtgccgacaa tcgcagatgc tgtcagccct gctgctaatt tctttttcat 915421 cttagctctc ctttttcccc caatgatttt gcatttgctg tttctttttt atatcggcac 915481 atttgtctca tcgttttgcc tttttataaa aatagccaaa ttatcttaac aataaggggg 915541 aaaaagggca taaaaaaaga aggaatctta atctattcct tcatttttaa aagcttcatg 915601 atatcttctt tgtttttgac gaggtcgcgc agtgtgtatt tgtctaaaac tgcgaggtag 915661 gctaaaagcg cttcattcag cacatgtttt aagccgcaaa ccggggaaat aacacagaga 915721 ttcttgttcg catcaaaaca ttcaacaata ttaaaatcgt cctccgtttt tctgacaacc 915781 tcaccgatgt tgatgtcttc agggtccatg cctaatcgta tgccgccgcc ccgtccgcgt 915841 atcgtttcta cgtagccgag ctggccgagc ctgtatatga ctttcatgag atgatttttt 915901 gaaatagaat acgtttcggc aatctgtttt atatttgaaa gttctccggg acgctctgca 915961 gccagaaaaa tcaacactct taatgaataa tctgtataat tggttaactt cataataaga 916021 cctcagaata agacattttc tatatcttat cataatcgat tgaaaaatga aaaaaaagga 916081 attaaaaaac atgcacccag ctgggtgcat gttttttgct tacatgtcat tcggcggatt 916141 ttggttttta cggttttttt cgatttctgt gttttgcatt ttgcgttcaa atgtagacag 916201 ataacgtgat gcaaaatcct taccgccaag gccgaaggat aaaccaaaag caagtgcgaa 916261 gccgctaaga acgatgatga acgcggaatt gacgattgtc gcagcgacac ccagctgatc 916321 cagggccata aagaaagcaa gtgcgataat cgtatattta gcaataggcg ctaaagactt 916381 gaattcctga ccttttatca tgcttgcgag cacttttctc accaattctc ctgcgtaaag 916441 gccgagtccg agaatgaata ctgcgacaag gacattcggc agatacgcga tgatgccggt 916501 ggcaatttct acgaggaagt gcagccgaac aatttgaagc gcctcagctg taaagagcag 916561 aatgacaatg atttgcgcaa tcataccgac aacttgagac aaggacagct ttgcaggcgt 916621 tccggcttcc atgcccattt tccctaagac agaatcaaag cctgcgcgat ggagcagtcc 916681 ggacaccatg gatttcaccc attttcctgc ccagataccc gctaatacaa gcacgatggc 916741 aatcatgatg ttcggaagca tgtttaaaat cgtattcagc atagagacag ctggttttga 916801 aatgccggcg acatccagct gatcaagcgc tgaaatgacc accggaatca taatgagcac 916861 ataagcgatt gttccgatga ctgctgaaag gcttgtgtct tttaagtaaa ttgataaacc 916921 catacgtgcc gcgaatcttt cggtgccgat gcttgcaagg aaattcgtaa tgatatcacg 916981 gacaaggcgg gcaacaagcc atccgattaa tacgataagc gccgctgcaa ataatttcgg 917041 cagaaaagcg agcacgcttt ccatcatatt tgtaaaagga cctgaaatgc cgctgatttt 917101 caaagaagat aagacccctg gcagaaaaac aagcagcacg agataaaaga caatttgtga 917161 agcggtattg acagcctggt gaatatcttt tccttcagac accaaattcc acttgcgcag 917221 tttgtcactc gtgttcagct tcatcccgat ttttttgaca aggaagctca aaacagaagc 917281 tgcagcccat cctaacagca gaatgagtcc ggctttcagc acgcttggga tcgcagctgc 917341 aatcgccgaa agcatactga caaacggcga tgccactgtt gtcaggtgca aaatgttaaa 917401 gaataaaata aagacgatga tcagtgcgat aaaataaacg accttgctta tgactttttc 917461 cgaggaatag cgtgaaggct ttttcccagc aaagagcttg tcgtcgattt ttgttttgct 917521 gagtcctttg tataccgctt tttcaatgat tttagcaata gcccagccga ttaataagac 917581 gagtaaagca atgattacgt ttggcagctt actgagataa gaagaaaaca cgtctgctac 917641 attcaattgg tatcgctcct ttttcgtagt atggtgtgtg tttacccact tatccaataa 917701 gcaaacagat gaatgtgccg ggggaatttt ttcttgcccg agtgagacta tcatcttttg 917761 tctggcgggc tcatacatta tagataagtc caagtagggg ggattcggtt gaacgcggag 917821 gagaagaagg gattacagcg ggcaattgag gaaattaccg aaattgcaaa aggattcggc 917881 cttgatttct acccgatgag atatgaaatc tgcccggctg aaattattta tacatttggc 917941 gcgtacggga tgccgacaag attcagccac tggagcttcg gcaagcagtt tcacaagatg 918001 aagctgcact atgatctagg gttaagtaag atctatgagc tggtcattaa ctcagatcca 918061 tgctacgctt ttttgctgga cagcaactca ctgatccaaa ataaattgat tgtcgcacac 918121 gttcttgctc attgcgattt cttcaaaaac aactgccgtt tccaaaacac gaagcgcgat 918181 atggtggaaa gcatggcggc aacagctgaa cggataaaac actatgaaca ggttcacggg 918241 ataaaagaag tcgaatcttt tttagatgca atcctttcga ttcaggagca tatcgatccg 918301 tcgttggtcc gaccaaagct ccaatggagt gtggatgatg aggaagagga gattgaagag 918361 gcagccacgc cttacgatga tctatggtct ttagatgaaa agaaaccgaa aaaacaagtg 918421 aaaaaatcga aaaaaccgtt cccgccgcgg cctgaaaaag atatcctgct ttttatcgag 918481 gagcattccc gggagctgga gccatggcag cgtgatatat taacgatgat gagagaggaa 918541 atgctttatt tctggcctca gctggaaacc aagattatga atgagggctg ggcttcctat 918601 tggcaccaga gaattatacg tgagcttgat ttaacctctg atgaagcgat cgagttcgcc 918661 aagctgaatg caggtgtcgt tcagccgtcc aaaacaggca ttaatcctta ttatttaggg 918721 ctgaaaatat ttgaagacat tgaaaagagg tacaacaacc cgacggagga aatgaagaaa 918781 atgggcgtgc agcctgactc cggccgggag aaaatgtttg aggtcaggga gattgaatcc 918841 gatatctctt tcatccgcaa ttatttaacc aaagaattag tcatgcgcga ggatctttat 918901 ttgtttcaaa aacagggccg agattataaa atcatcgata aacagtggaa gtcggtgcgc 918961 gaccagctcg taagcatgcg ggtaaatggc ggttttccat atttgacagt aaacgacggc 919021 gattatatga aaaataacga actctatatt aagcattggt atgagggcat agagttggat 919081 ttgaaatatt tggagaaagt gcttccttat ttattccagc tttggggaag aagcgtgcac 919141 attgagtctg tgcttgagga taaggaagtc atgttttcgt acgacggaaa aggtgttcac 919201 cgcagatatt tataaaaaag aggatgcagc gttctgcatc ctttttattt tccagttttt 919261 aaaatcttaa atatgatgtt tgcctggtcc gtattgttaa tcaatccgcg gaatttttct 919321 tttccggggc cgtacgcgta taccggtact tcttcgccgg tatgatcggt actcgtccat 919381 ccgctgttgg agcgggtatt aaaaatcttg atgatggctt tggaggcccc tttgcttttg 919441 tcagcctgtg cagctgcttc aacgcttttg atttcttcag atgtgacttt cagattggca 919501 tagcgggcga gcacatcttt aaccggcttg ccttcactga tttttttggc catgaattca 919561 ggtgttttct tagcggagag aatcggttct gcgtgccaat tcttttcccc gtttgcgcca 919621 atggtaaagc cgccggttgt atggtcagca gttgcaatca caagtgtatg tttgtctttt 919681 ttcgcaaatt caatcgcggc tttataggcc tgttcaaaat ctttaacctc gctcatggct 919741 cctactgtat cattgtcatg ggccgcccag tcaatctggc tcccttcgac catcaagaaa 919801 aatccttttt tattttggtt caggcgatca attgctgaaa ccgtcatgtc tttgagagac 919861 ggtgttttac tgtcacggtc gagcgcttta gcaagccctc catctgcgaa aagcccgagc 919921 acctgctgat ctttattttt tttcaatgct tgtttagttg tcacatagct gtagccggct 919981 tgtttgaatt cctttgtcaa gtttctgtcc ttgcggttaa aataagattt tccgccgccg 920041 agcagcacgt ctattttatg tttgcctttt atcttgtcat ccatatagct gttggcgatt 920101 tggtccatgt ttttccgtga ttcattgtgg gcgccatatg cggctggagt ggcgtggtta 920161 atttcagacg tggcgacaag ccctgttgac ttgccttgct gtttggcctc ttcaagtaca 920221 gatttcactt tttttccgtt tttatcgacg ccaattgcat tgttatatgt cttaacgcct 920281 gtcgctaatg ctgttccggc tgctgctgaa tctgtaatat tatagtcagg gtcatccgga 920341 tgcgtcatca tcatgcctgt caggttccgg tcaaattctg ttaacttcgg gttattcggt 920401 gtgtcaccgt tatttttcat ggaacggtag gctcttatgt aaggcgtccc catgccgtcg 920461 cctatcatca caatgacatt tctgatctca gctttgtctt gttttttggc gctggccttt 920521 tctgtttgct gaagctcagc tccggcaaag attccagctg taaggacaga aacagcggcg 920581 attggcagaa gttttgattt catattttga aacaaactca tttttttcat gcctccttta 920641 atgtattccg tttatcatgt tagggaaact ttgttaaatg cggctgttga tcatgtaaac 920701 aataagtaaa gccttgtaag gaaatgaaaa aacgcttttc gttatcttgc cttatttgat 920761 gtaaagcatt catttttcag aaaaatcttt acctctctgt ctttgcatga tatgtttgtt 920821 taaataaaaa aactgcggat aaccacagct ctcctcgaat atactttatc actcattttt 920881 ccgatatatg agccgacccc gaaagttttt catttatttc ctttatgttg aaaaacatcc 920941 cataaaacat gacaaaagca ctcgtttttt gtcacctttg caatgaaaat gaaatattta 921001 atacccttaa aaactttttt ttagaacgaa taattaagaa atttgtcaca tgaagtcaag 921061 actatttctg atgggaatct atccttataa tagaaatcaa taagattaat ttaaaaaaag 921121 agatacatat atatagagtt aacatttggg gaggaaaata tgaaaaagca aatcattaca 921181 gctacgacag cagttgtttt aggatcgacg ttatttgcag gagcggcatc tgcacaaagc 921241 attaaggtga aaaaaggcga cacgttatgg gatctttcaa gaaaatacga cacaacgatc 921301 agtaaaatta aatcagagaa ccaccttcgt tcagacatta tttatgtggg acaaacttta 921361 tcgattaacg gcaaatctac aagttcaaaa agcagcagtt cttcttcctc ttcttctaca 921421 tacaaagtaa agagcgggga cagcctttgg aaaatttcaa aaaaatacgg catgacaatc 921481 aatgaactga agaagctgaa tggcttaaaa tcagatttgc ttcgtgttgg acaagtcctg 921541 aaactgaaag gttcaactag ttcaagcagc tccagctcat caaaagtgtc atcgtcttca 921601 acttctactt ataaagtgaa gagcggagac agcctttcta aaattgcgag caaatacggc 921661 actacggtta gcaaattaaa aagcttaaac ggcttaaaat cagatgtaat ctatgtcaac 921721 caagtattga aggtgaaagg aacaagcaca agcagctcaa aacctgcttc atcttcatcg 921781 tcttcaagca gcaaaacgtc atctacatca cttaatgtga gcaagctggt ttctgatgca 921841 aaagcgttag tcggaacgcc atataaatgg ggcggaacga caacttcagg ctttgactgc 921901 agcggattca tttggtacgt actgaataaa caaacaagtg tgggcagaac aagcactgca 921961 ggatactgga gttctatgaa gagcattgcc agcccgtctg ttggtgattt cgtcttcttc 922021 acaacatata aatccggccc ttctcacatg gggatttaca ttggaaacaa cagtttcatt 922081 catgcaggat ctgacggcgt acaaatcagc agcctgaaca acagctactg gaagcctcgt 922141 tacctcggtg cgaaaagatt ctaattttta gagaaaaccc gttcattgga acgggttttt 922201 ttcattagac ggagcacagg cgttttggtt gctcctaaaa atgaaaatgt gataaaaaat 922261 ccaagaactt tttttctttc ttattttcat aaagggcaat cgcgtaagcg ccggcatagg 922321 gcagctgtac agactgataa ggaattctga tcatctgttt ctctgctaac tcacgcttta 922381 ctgtagataa aggcagaaat gaaactccga gtccttcctt gataaaccgt ttcgttatat 922441 gtgtttgagt gaccttcatt gttctcacaa atggaaatgt cattctgact tgacggagca 922501 agtcgtccca gtaatcagga tgattgtggg tcaaaagcag gtattgttcg agcacctctt 922561 tggcatcaat ttcgttgtct tctatgaaac gcttatcggg cggggcaaca aggacgacag 922621 ggtctttgta taagcagtgg cagcttaaag aagaagactg tacctttaaa cagcttagtc 922681 cgatatctgc ttccccggct ttaatcagtg acgcgatttc cgctgattcg aaaatcgtaa 922741 ccgccatttc tgtttccgta ttcattgctg tgtaccgctt catgacagaa ggaagcactg 922801 tatctgcaat aagcggagaa accgcgagct gtaaggtttg agagtagcct tgtctcactc 922861 tgtgaagctc tgccatgctg ttttcataat catcaagaag cctgagcgca tacggcaaat 922921 acgccctgcc ttcatcagtc agctggattt gcctgccttt acgctcgaac agcttgcagc 922981 tgatttcttt ttctaattgc ttgatatgta cggtcacagt aggctgagat aagaaaagcg 923041 tttccgccgt ttttcggaag ttctcatatt ttgcagcggt cacaaaggtg tgaagccatt 923101 tgaaatccat ttctattctc cctctgatta atatttttaa ttaattccct ttaaaatatt 923161 gattattttt taaatattat atttactata ataacagaaa aggatagggg gaatacaaat 923221 ggtacattac ggattaaagg gaattacatg tgtagaaaca tccatcagcc atattgatgg 923281 tgaaaaaggg cgtctgattt acagaggaca tcatgcaaaa gacatcgcac tgaatcacag 923341 ctttgaagaa gcggcttatt tgattttatt tggaaaactg ccttcaactg aagaattgca 923401 ggtatttaaa gataagctgg ctgcggaacg gaatcttccg gaacatattg agcgcttgat 923461 tcaatcactg ccaaacaaca tggacgatat gtcggtgctg agaacggttg tttcagcatt 923521 gggggaaaat acgtacacat tccatccgaa aacagaggaa gcaatccggc tgattgcaat 923581 cacgccttct atcattgcat acagaaaaag atggacgcgc ggtgaacaag caattgcacc 923641 ttcttcccag tacggacatg tcgaaaacta ctattatatg ctcacaggtg aacagccttc 923701 agaggcaaaa aagaaagcgc ttgaaaccta tatgattctg gccacggagc acggcatgaa 923761 cgcatcgact ttttcggcac gagtcacgtt atctacagag agtgatttag tgtcagccgt 923821 cacggctgct ctcggtacga tgaaaggtcc gctgcacgga ggtgctcctt ctgcggtgac 923881 aaaaatgctt gaagacattg gagaaaagga acatgctgaa gcatatctga aagaaaaact 923941 cgaaaaagga gagcgcttga tgggattcgg ccacagggtg tacaaaacaa aagacccgcg 924001 ggcagaagct ttgagacaga aagcagaaga ggtggccggc aatgaccgtg atcttgatct 924061 tgcgctgcat gtagaagcag aagcgattcg tttgctagaa atctacaaac cgggacgaaa 924121 gctgtacaca aatgttgaat tttacgcagc tgcagtgatg agggccatcg attttgacga 924181 tgaattgttt actccgacct tttcagcaag ccgaatggta gggtggtgcg cccatgtact 924241 ggaacaggca gaaaacaaca tgattttccg cccgtcagcg caatataccg gtgccattcc 924301 cgaggaagtt ctttcataac atattttggc gtttattcat ttctgtcgtg tggtaacgtt 924361 cagtatcaac cacatgtcta ggagtgatga atgtgaaccc aatggacaga caaacagaag 924421 gacaagaacc gcagcatcag gacagacagc cgggcattga gtcaaaaatg aatccgctgc 924481 cgctgtcaga ggacgaggat tatcgaggaa gcggaaaact gaaaggaaaa gttgcgatca 924541 ttactggagg cgacagcgga atagggagag cagcagctat tgcctttgct aaagaggggg 924601 ctgatatctc cattctatac ttagacgagc attcggacgc agaggaaaca cgcaaacgga 924661 tcgaaaagga gaatgtccgc tgcctgctta tcccgggaga tgttggggac gagaaccatt 924721 gtgaacaagc tgtgcagcaa acagtggacc attttggtaa actcgatatc ttagtgaaca 924781 acgccgctga acagcatccc caggacagca ttctcaatat ttcaacagaa cagctggaaa 924841 aaacctttcg cacaaatatt ttttccatgt ttcatatgac gaagaaagct ttgcctcacc 924901 tgcaagaggg gtgtgccatt attaatacga catcgattac cgcttatgaa ggggatacgg 924961 cgttaattga ttattccagc acaaagggtg cgattgtttc ctttacgcgt tccatggcga 925021 agtcgcttgc agataaaggc atcagagtga atgcggtggc gcccggtccg atttggacac 925081 cgcttattcc ggcgacattc cctgaggaaa aagtgaaaca gcacggcttg gataccccaa 925141 tgggaagacc gggacagccg gttgagcatg caggcgccta tgttctgctg gcgtctgacg 925201 aatcttccta tatgacaggg cagaccattc atgtgaatgg cggccgtttt atttcaacgt 925261 aatcaacgaa aaaccagctc aagagctggt tttttgtgtg gtgaaaaatt tcaaaataaa 925321 aaatttgtcg atttttctaa caattttgtt ttcatttttg caattttata tataatattg 925381 agtaggagaa aggaatgatt cgcgaccagt acaaatatag tagaaaaaaa agaataatga 925441 ccattgttac tcatgaattc agaaaattca aataaaatat ataaaaatag atgatcggga 925501 gttgaagggg aatgaaaggg agcgttttta ggaagaaaag cattcaggat ttaatcgctg 925561 cgacgagcgg ggaaaagtct ttaaaaagag aattaggggc atttgattta acgttgcttg 925621 gaatcggcgc cattattggc acagggattt ttgttctgac gggaacaggc gcagtcacgg 925681 ccggtcccgg gctgacgatt tcatttgttg tggcggcgtt ggcttgttta ttcgccgccc 925741 tgtcttacgc ggaatttgcg tcaagtgtgc ctgtttcagg ttcggtgtat acattcactt 925801 atgcgacatt gggagagctt atggccttta ttatcgggtg ggatttaatt ttagaataca 925861 tgctggcggt aagtgcagtg tcggtcggct ggtctggtta tttccaatcg tttttatcag 925921 ggcttggcat tcatcttccg gttgctttaa cagcggcacc gggcgcagtg aaaggcacct 925981 ttaccctgtt taatcttcct gcattcgtca ttgtaatggc gatcacatat ttgctttatt 926041 taggcatcaa agaatcaaaa agagtcaaca atatcatggt tatcttgaag atactggttg 926101 ttctgctgtt tatcgcggtg gcagccgttt acgtgaagcc gcacaactgg cagccgttta 926161 tgccaatggg ctttggcggc gtgttcagtg cagcggcgct cgtattcttt gcttttatcg 926221 gatttgacgc tgtatcctct gctgcggaag aaacgaaaaa tcccgcgaag gatctgccta 926281 aaggcattat tttctcttta ctggtctgca cgattttata tgtcaccgta tcagccatca 926341 tgactggggt tatcccgttt gctcaatttg cgggtgtgga tcatccggtt tctcttgttc 926401 ttcaaagcgc agggcaaaat tgggtggcag gcatcattga tattggcgcc gtgttgggaa 926461 tgacaacagt tatgctcgtg atgctttacg ggcagacccg cgtcatgttt gccatgtcgc 926521 gtgacggact tgtgccgggt tcactttcta aagtgcatcc aaagcacaaa acaccttatg 926581 tagccacttg gtttttcgga acgatgtcgg cgcttctcgg ctcacttgtt ccgctggatg 926641 aacttgcaaa gctggtgaac atcgggacgt tgtcggcatt tgtcctgatt tctgtggcag 926701 ttatcgtttt gagaaagaaa cagcctgatc ttccgagagc ttttaaatgc ccgggagttc 926761 ccgtgatccc aggcctggcg attctgttct gcctgttctt gattttaaat ctgggatggg 926821 tgacgattgt ccgcttccta gtgtggctgt taatcggctt ggtaatctat ttcctgtatt 926881 caagaaagca ttcaaaatta aatcaataac cttttgataa agagagcggc catacaggcc 926941 gcctcttttc tgttcttggc aaatgaatct atagaaatga agacaaaaat aagagataat 927001 ataggctgga aaggaagtga cgtttattgt ctgagcaaaa accagtccaa tgggcttcga 927061 aaattggttt cgtcatggca gcggccggct cggctatcgg cttgggcgcg atttggaagt 927121 tcccttacgt agcggggacc aatgggggag gagccttttt tcttatcttc gtgttattta 927181 ccatcctctt aggctatccg cttttggtgg gggaatttat ttttggaaga cggaaccaga 927241 cgaatgccat tgatgcatat aaaaaagaag cgccgcgatc agcttggttt cttacggggt 927301 ggatcggcgt agcggcgtgt ttcttagtgc tgtcgtttta cagtgtaatc gggggatgga 927361 ttttgctgta tatcgtgaaa acagcgtcag gatcactgtc cgggctttct caagcacagt 927421 atggcgctct ttttgcttct attatccaaa atccggtgca gacgctcgcg gctcagcttg 927481 tctttatggc actgactgta ctcgttgtcg caagaggggt tcaaaaaggg attgaacggg 927541 taagcgcggt gatgatgccg attttgtttt tattgtttat tctgctcgtt cttcggtctc 927601 ttacgcttaa tggtgcaatg gaaggcgtaa agtttctgct tgtgcctcat ttcggcgatc 927661 tgactccgga atccatatta ttcgcgctgg gacaggcctt ctttacgtta acactggggg 927721 tttcggtgat ggtgacctac agctcctatt tgccgaaaac acaaaatatc cctcgttcgg 927781 cagcctccat tgtcttgatg aatatcattg tgacactctt ggcaggtttg gctatttttc 927841 cggcggtttt ctcattcggt tttcagccaa atgaaggacc gacattgctg tttacagtgc 927901 ttccggccgt ttttgaacag cttccgttcg gcacattgtt ttttatcggc tttctcgttg 927961 catttttatt tgcagcctta acctcagcat tttcgatggt tgaaattatc gttgccacaa 928021 tcggaaaagg ggacgaaaag aagagaaaaa aactgtcatg gacgagcggg cttttgatct 928081 ttttggtcgg aatcccatgc tgcttgtctt atggcgtttt gagtgatgtg cacctatttg 928141 gcaaaacgtt ttttgatatt gccgatttta ccgtcagcaa tgttttgatg ccttcaggcg 928201 ctctgttaat ttctctattt atcccgctga aaatttcgaa aagcgaactc ttggctgaaa 928261 tgcgaaatgg atcaaatgca ggtaaagcat tcttttacac atggttttat ttgcttcgtt 928321 ttatcgtgcc gcttgccatt attatcgtgt tcttaaattt aatcggaatt ttatcatttt 928381 aaaaaacagg ctccgtttcc ggggcctgtt ttttatttaa taagatgata tcaacggtgc 928441 ccatgccgtt ttcagttttt ggatgccgag cctgatgtcc tcttctgaca aaccgccata 928501 accgattaag acagaagtaa aaggcgtctg ttctatatat gagggagaca cgggatagag 928561 ggttacaccg tggtcagcgg ctgcttgtat tgcttcttcc tcacttgctg gaaacaaaag 928621 gcgcagcaga atgtgaagcc ccgagttctt accgagaatc tcaacggtgt ttcccagttc 928681 agagcgaatg gcttctaaca ggacagcgtg tttttttcgg tataagcttc tcattctatt 928741 tatgtgtttt tgccactctc cggtttcgat gaagtctgcc agtgccaatt gcgagtgggc 928801 agaaacggtc tgcttcatta actgaacatt gttttggatc ggttccatga gttcaggggg 928861 cacaatcatg aagctgagcc gcaaggaagg cagaagtgac tttgaaaaag tgcccagata 928921 tatgactctg ccattcggat caagaccctg taaagacgga atgggatggc cgctgtagcg 928981 aaattctcca tcgtaatcat cttctataat gaatgaattt gtttctgccg cccatgccag 929041 cagctcctgt ctgcgggtaa tcgtcataat ggtcccaatc ggaaactgat gcgaaggagt 929101 cgtatacatg agataaggat tctgacggta gagctcatcc ggcaggacgc cttctgcatc 929161 agaacaaatc ggagtgacat ccatgtgatt tgcttcaaac atccttcttg aacggtgaaa 929221 gcccggttct tcaaagccga tttttgtacc tggctttagc gaaaggcaaa gattttgcag 929281 aagcacggtg gttcctgcgc cgatgataat ctggccgggt tcacaattta ctccccgaga 929341 cagcctgacg aatcgggcaa tcatgtgcct gagttcgtat tctccttgag ggtcgccaga 929401 ggtgtgaaac gatccggaat agcgatcaag actttttact atgctttttc tccatgcgtt 929461 aaagggaaag agggtcggat caacgctgcc ctgatggaag tcaatagcag gtgcgttttt 929521 ttgatgtaat cccggctgta cagactgctg aaaatggtca ggagctgtcg ggaatcctgg 929581 ttctacttcc gccgcgaacc agccgatttt cggcttgctt ttgacatagc cctcagcagt 929641 taattgctca taagctcgtt ctatagttgc cgtgctgaca tcgagcaagc tggagagcct 929701 gcgttttgac ggaagtcttg ttccctttgt gattcgcgca tgtgaaattt cttgtttaaa 929761 aaaggtataa agctgttcat acagcggtgt tttgctcttt ttatcaagaa acggcgtaat 929821 atccatctca tgtctccttt gtagctggca tggtcatttt ttctgatatt ggctatttgg 929881 caaatgccat ttattagcta tgatcattgt aacgaaagga aaggggattg agaagatgat 929941 ccatatgaaa caattaacct cgaaagaaga atgggctgag tcgtatccga ttatgagtga 930001 attgagaaca gaactggata tagagacgta tttacaaagg cttgaagcct gtgtgcagaa 930061 agaatcgtat atgctgtttg ccttatatga aaatacagca atcagagcgc tgtgcggggc 930121 tctgccgaga gtttccattc ataaaggaga gcacttgtgg attgcggatc ttgttacaac 930181 ggcaccttgc cgatcaaagg gatacggcaa aatgcttttg gattatgcct cagactgggc 930241 gagaaaagcc ggactcggtt ttgtcagtct ttcatctggc cttcagcgta aagacgcaca 930301 tcgattttat acagataaaa tgggttttac tatagaaagt tatttgttcc gaaaaccggt 930361 ataacgaaaa aagacgcctg aaaaggcgtc ttttttaaaa gccaaactgt aaattcgtat 930421 ctacagatac aatggtatac acacaaataa tcacaaagag attaaggatg acgccgagca 930481 ggcctggacc tgtgcgccct ctcttgatga agagttcaac aacgccgaac ggaacggcag 930541 ccatggcgaa cggaagcatt tgataggaat aaaacgtgac gttgctgata atggccaaat 930601 tcagcaacag cagggacaga accgctgtcc cgacagagat ccagccgaat acattgtgtt 930661 ctttaaaaat tcttaccagt tccataattc cacctcgccg acattcgctg attttacaga 930721 tttatttttc agcatgcgct ggatttcctt ggttggccct gtaacgaccg aaccgtatac 930781 attgacaccg tttttctcta cataatctaa tcggttatct acattcaggt ctttccgttt 930841 tgaaatgacc tgagcccatt tttcgtgttt ggacatgaat ttcagggcgt tgataaactg 930901 atcgccattc gacttgcctt ttgtattaag ggcggccaag aactttgaat cctttccagg 930961 atagccaaga ggttctgtgg aagctgtctt atttgtgttt ttctctgttt cgattgcgtt 931021 ccacaaaaag ctcacatcat agcctttgaa tttgttatac acgtcttttg tcggatatgc 931081 acggtcatat gaaaggtaga cctctgatac cgttccttca ggcaatgtgc ttaacgtttt 931141 ttctgctttt gcggtcgttt gttcagactt gtttgaagga tgtgtaaagt aatggccggt 931201 tttattcact tctaagtcat agtagtttac tgccggcgct tttactttgt tataaaacat 931261 ttcaacccgt tcattcccta cggcagccgt cttcgtgcca atctgctttt gcagcgggaa 931321 ttccgtattc attccaaata gcttcacttg gcttttcagt ccggaagtat caacaagaac 931381 attcggcatg gtcagggcta cagtgactgc ggcagtttcc ataaactcat tgccggtgct 931441 gtgttttcca cccattccgt aatagaggta gcttcccagc gtacaaagcg gcaaaatcat 931501 caatgtcgaa atgacggcaa gcacagaaat tcgcaaataa gacttgcgtt tgccgtaggc 931561 taaaatcgct ttttgttttt caggactgat gctgagatcc caatcgttat cgtcctctag 931621 ttcgctgtca atcagttcct gatatacttc aagcttctcg agttcttcct caaatgcagt 931681 catttcctgg tcgctcattt ccccattttt atattgatca aaacgctttt taaattcttc 931741 attcatcatt aacacctcta ttataaagtg ctttcagccg ctgtctggca cgaaataaaa 931801 cacttttaaa attcgcctct gaaatattca taatatggga tgcttctttg tagtttaact 931861 cttttaaata atatagcgtt aaggcctccc gataattatc ggggagctcg gacatataac 931921 cagtcagcac ttcctttatc tctacctgat gggcaggact ttgaacagca ttttgaaaga 931981 ggcttccgat taagtcatca gaaatggtta cttctttctt atgctttctg acgtaatcaa 932041 tgaaggcgtt tcgcgccact tgaaaaagcc agggctttac tttgctgtga tcataggagt 932101 gaatgtgtat gtatgcccgc ataaaggttt cctgcagtaa gtcttcagca agatgcttgt 932161 cttttgtcat ggagagcagg aacctgtaaa catcattcat gtacatttgg taaatttcat 932221 cgatcgtcac tgccttttct cccctctatg ttatacacgc ataagaaagg tttaaagttg 932281 cacattacat gcaaacggct tttttatacc taatcaaaca ccattactat atagtaccca 932341 aaaatggccg caaaagatag tgcggagaaa ggtttaacat tttttccaga ggggaaaaga 932401 tagtgaaaaa gtgaaggagt ggcacaatgg aatataccag tatagcagat acaggaatag 932461 aagcctccag aatcggcctc ggcacatggg ccattggcgg aacgatgtgg ggaggcactg 932521 acgaaaaaac atcgattgaa acaatccgcg ccgctcttga tcaggggatt acactgattg 932581 acaccgcacc ggcttacggc ttcgggcagt ccgaggaaat tgtcggaaag gcaatcaaag 932641 agtacggcaa aagagaccag gtgattctcg caacgaaaac ggctctggac tggaagaaca 932701 accagctgtt ccgccatgcg aacagagcga gaattgtaga ggaagttgag aattctttga 932761 agcggcttca aacagactat attgatcttt atcaggtgca ttggcccgat ccgcttgtgc 932821 caattgaaga aacggctgaa gtcatgaagg aattatatga tgcgggaaaa atccgggcga 932881 ttggcgtcag caatttttca attgagcaaa tggatacatt tcgcgccgtc gcacctctcc 932941 atacgattca gcctccatat aatctgtttg aaagagagat ggaagagagt gtccttcctt 933001 atgcgaaaga taacaagata acaacattat tatacggcag tttatgcaga gggctgttaa 933061 caggcaaaat gactgaagaa tatacatttg agggcgatga tctgcgtaat cacgatccaa 933121 aattccagaa gccccgcttt aaagagtatc tttctgctgt gaatcaattg gataagctgg 933181 cgaagacacg ttatggaaaa tcagtgattc acttggctgt cagatggatc ttagatcagc 933241 cgggagcgga tatcgctctt tggggagcaa gaaagcctgg gcagcttgag gccctatctg 933301 agattacagg ctggacgctg aacagtgaag atcagaaaga tatcaatact atattggaaa 933361 atacgatatc agaccctgtc ggaccggagt ttatggcccc gccgaccaga gaggaaatat 933421 aacaaaagct gagggcgaat cctcagcttt ttggcgttta aacgagagaa atcttaaaaa 933481 ttagtaccag gtaataaaaa atattgttat aatagatgac agaaagaatc attgattacg 933541 acaaaggaag tgcgatatgt ataagttttg tgcaaatgct ttaaaagtta ttctttctct 933601 tcgcggagga gtgaaggtgt ataacaaaga aaaccttccg gccgattcag gttttgtcat 933661 cgcgtgtaca cattccggct gggttgatgt gattacactc ggagtcggga ttcttcctta 933721 tcaaatacac tacatggcga aaaaagagct ttttcaaaat aaatggatcg gttcgtttct 933781 gaagaaaatt catgcctttc cggtagatcg ggaaaatccc gggccaagca gtattaaaac 933841 gccgattaag ctgctgaaag aaggagagat cgtcggtatc ttcccaagcg gaacaagaac 933901 ctctgaggat gtgcctttga aaagaggtgc ggtgacgatt gcgcaaatgg ggaaagcgcc 933961 gcttgtcccc gctgcatatc agggcccttc aagcggaaaa gaattattca aaaaaggaaa 934021 aatgaagctg attatcggtg agcctcttca ccaggctgat tttgcccacc tgccttcaaa 934081 ggaaagactt gcagcaatga cagaggcttt gaatcagcgg attaaagaac tagagaataa 934141 acttgatcag ctataaggcg ttctgagaga ttgtcctgaa actgtgaaaa taagaaaagc 934201 accctataca aggtgctttt cttattatgc ttcctgctgg ttagctgtct ccagaagttc 934261 ttcttcttga agctttttca cttcaatata tgcgacgtgg tggccgtcaa tttcattaat 934321 gatgaattcg cagccctctt cgatgatgga atcatctttt tcaacatcgt atttttgagt 934381 aaggaaccag ccgccgattg tatcgacttc ttcgttctct aaatggatgc ctagcaggtc 934441 gtttacttgg tcaattaaca cttttccgtc aagaatataa tggccttcgc cgattttgcg 934501 gatttcgcta atttcatcaa tatcaaattc gtcgcggatt tcaccgacaa tttcctcaat 934561 gatgtcctca accgtcacaa gcccggcagt accgccgtat tcatcagaca aaatggccat 934621 gtggaccctc tctttttgca ttttgacaag caggtcttgg atcggcgcag attcaatgac 934681 atgaatgata gggttgacga attgagaaat ggtggaatca acagatacct caccgctgat 934741 gcaggcggtc agcacttctt taatgttaat aaccccgata atgttatctt tatcgccctc 934801 ttccacaggg tagcgggtat atttttcaat ctgaatgatg tccatcattt cagaaatctt 934861 gatatcatgc ggaaggctga caatttcggt ccgcggaatc ataatttctt tcgcgagcct 934921 gtcgtcaaat tcaaagattt tattcacata tttaaactct gattggttga tttcaccgct 934981 tttatagctt tcagacaaaa tgattcgcag ctcttcttct gagtgagcca gttcgttttc 935041 tgaaacggtc tccaggccaa atgctttggt caataaccgt gcggaattgt tcaaaagcca 935101 aatgaatggg aacgcgatgc ggtaaaacca aatcagcggt ttcgcaaaca gcatagacac 935161 tgcttccgcc ttttggatag cgactgtttt aggtgcaagt tctccgacaa caacgtgtaa 935221 gaacgtgata atggcatacg caaaaataaa cgatatgaca tgtgaaaggg aacctggaac 935281 gttcatttgg acgaaaagcg ggtgaagcag cctttcgatc gttgattcac ctaaaacccc 935341 taatccgatg gaagtcaatg taattccgag ctgacacgca gataaatatt catcaagatg 935401 cgtggtcact ttttttacgg ctattgctgc tttatttcct tccgcgatca gctgatcgat 935461 ccgtgagcct ctgattctga taatggcaaa ctcagatgcc acgaaaaatg ccgtcagggc 935521 gattaaaaca gcaactaaaa tcaaattcac tatgtccaat tagaaccttc actctagcaa 935581 tgagaatgaa ggtaacacct cctgttagat aaaatggttt taacttaaca gcagcataaa 935641 tgattggaac acggcgagct tttcaggcgg gagtttgctt ttcagcttgt cacgatcctc 935701 gggcttcagc cgttcaaacc gatgcaagat tccggagatg ttttgattca tatgatcaat 935761 ttctaatgcc agatttccaa tttcatcatc aagtttagct gaagagggaa actggttctc 935821 cagtcgatct ttaatatcgg acagggccaa tcgctgcttc ttgcaatcta caataaatat 935881 aagtcgtttg agtgcatttt cgtcgtagta acggtaattt gaacaggatc tggccggcgt 935941 aagcagaccg agattcgtat aataatcaac tgtccgtttc gttactccgg cgagtgccgc 936001 tagttcactg atgcgataag tctcagcccc atctatatcc ctcccaacca tcacgttata 936061 gttatgagaa tagtttaata tatgaacggt gtcttgcaca agtttattgt tttttttaga 936121 ccggaattgg aagttgtgga attcatcatc tgattgaagt aacataggaa gatagaattt 936181 tcaaattttt atatgcggaa gggacagatg aaattggctg ggttatcccg ggaagttgaa 936241 gaaaacttaa ataaaggatc atggattcgc aagctgtttg atgaaggtgc aaggctgaag 936301 aaggagttcg gggaagacca ggtatttgat ttttcactcg gcaacccgat tgttgaaccg 936361 cctgaagctt ttaagagagc gttaatagag gaagctgaaa aaggcagcca cggatacata 936421 caaaaccaag ggcttcttgc agcgagagaa aaagtcgcgc aatttctggg ctcgcgtttt 936481 gaagctgatt tctcagcgga gcgcatcgtc atgacggtgg gcgcgggagg cgctttgaat 936541 gttgcgttaa aaagcatcgt aaaccctggg gaagaggtca ttattcttgc accttatttt 936601 gccgaatata agttgtatat tgagaactac gggggaaaag ccgtcagctg cccgttgaca 936661 agccggtttg agatcgacat tgaagcggta aggcaatcga tcactccaca gacgaaaggg 936721 ctgattctca atacaccgca taaccccaca ggcactgttc tcagccagaa aaatatagac 936781 gatttaggcg ctttattaaa agaaatagaa gagaagagcg gccagacgat ttatgtgctg 936841 tttgatgaac cgtacagtca attaatctat gatgaagagc tggcaaatcc gtttcaatcg 936901 taccatcgtg tgatattggc cagctcattc agtaaagatc tcggcatagc cggagagcgg 936961 ctcgggtata tcggattgga cagccgaatg ccggatgcgg accttttgat caacgctttt 937021 gtgtattgta atcgaacgct tggatttgtg aatgcccctg tcatgatgca gcgggctgtg 937081 gcacgaatgg atgatttaag agtagacgcg agcgcttata aagagcgccg ggatttaatg 937141 gtagacattt taaaagaagc cggttttgaa tttgaaatgc caaagggagg tttctttgtt 937201 tttccgaaat cgccgattga agatgaagtt gcattttgcg tgcatgccgc ccaaaaatac 937261 aaattattaa ttgtgccgag cagcggtttt ggaatgagcg ggcatttccg attatccttc 937321 agtgtgccga tcgagcagat taaaaactca cgggacattt tcatttcttt atataaagat 937381 tttgcttaag aaggcaaaga aaagaaaaca gttttcaagg ctgttttctt tttatatccg 937441 caaaatcctt cctcttccaa tccagacagg cgcagaattg acaagcaggc atgcagttaa 937501 ggctttcttc atgataaaag tctaaaaatt aaaaatcatt tttggaatga gttgtgttac 937561 aataaaatat acaatttata atcaaacttt gacttttgga ggtggtatga tggggccctc 937621 tgcttaggca acaatacacc gcgtacctca atgttaagga aaaatgatta tatcaggagg 937681 tgactcctta tcctttgttg agaggatagg gttaaatgga cgatattgac agtctgattt 937741 taattggcgt gctcattgct ttaaccgcgt ttttcgttgc aagcgagttt gcgattgtta 937801 gagtgaggag atccagaata gatcagctta tcacagaagg aaacaaacgg gcgatactcg 937861 caaggcgtgt cattacagat ttggatgaat atttatccgc atcccagcta ggcattacat 937921 tgacatcaat cgggcttggc gtactgggtg agccggcctt tgaacggctg ctgcatccac 937981 tgtttgaacc gctcggcttg ccggactcgg tttcacatgc agtctctttt gcagtcgcgt 938041 acggcttgat cacgttcctg cacgttgttg taggtgaact ggccccgaaa acggtcgcga 938101 ttcaaaaggc agaacagctg actttactga tagcgggccc tttgcgttta ttctatttgc 938161 tcctgtttcc gtttatttgg atcctcaatg gatcggcgcg gcttttatgc gggatgttcg 938221 gtttgaagcc tgcgtcagaa catgatggtt cccattctga ggaagaactc aggatgctgt 938281 tatctgagag tttaaaaaac ggagagatta atccgtctga atataaatat gtgaataaga 938341 tttttgaatt tgataatcgg atcgccaaag aaattatgat accgcggaag gaaatggctg 938401 ctgtgtcaac tgagatgacg atggccgaga tgcttgaagt catgctgaag gaaaaataca 938461 cgcgctggcc agtcacagat ggagacaaag acagtgtgct cggtttggtc aatacgaagc 938521 atttgttttc tgatttgctg tttatgacag aagaagaacg aatgaagatg acgatccatc 938581 cgtatgtgag gccggtcatc gaagtgattg aaacgatccc ggttcatgac ttgctgatta 938641 aaatgcagcg cgagcgcatt catatggcta tattgtcgga tgaatacgga ggaacctcgg 938701 gacttgtgac gacagaggat attcttgagg aaattgtcgg agagatccga gatgaatttg 938761 atgaagatga acagccgctg atccaaaagc ttggcgacgg ccattatgtg atggatggaa 938821 aggttcggat cgatcaggtg aacagccttc ttggcgcatc gattcaagaa gacgtcgata 938881 cgatcggcgg gctgatatta aaagaaaaca tcgatattga ggctggtgaa tccattcgca 938941 tcggttcata tacgataaag gtgctgaaga tggacggccg attaatcaag caaatcgata 939001 taaaagaaga agccggcaac acaaccggga ttacggcgca ccacaagctg ccgctgcccg 939061 agcctgtgat gctgaacagt gcaaccttga gcgagaaata agctcaaggt ttttttatat 939121 tgtgattgtc cagccgcacc aaaatgcaaa aagcgacccg caaagtgtca ggacgatgta 939181 caagatgctt tcttttacac gtttggccat aaggagttga atagtttcaa cgctgaatgt 939241 ggaaaaggtc gtaaaggcgc caaaaaaccc cgtgccaatg ataagcgaga ccgaagcatt 939301 tgcaacgtga agtcctgtaa atattccgag cccgagagct ccgagaatat tgactgtcag 939361 tatgccaatg ggcaggctga gacctttggt tttggcggtt atgacattgc caagccagaa 939421 gcgaagcatt gcgccaagtc cgccccctat gaaaataccc gctagtgtca tttttcctgc 939481 agcccctttc tttgctgaat gcctgctatg cgccgtccca caaaaacacc aatcagtgca 939541 aatatgatcc ctgatatcaa tgaggctgcc acatataaaa gagccaatga gggttgtcct 939601 tgcaaaagca tcactgtttc cttagaaaac gtggacattg ttgtgaagcc tccgcaaaag 939661 ccggtgccta aaaaagccga cagcagaggc cgttttgccc cgatcataaa aaatccggtc 939721 aaaatgccta atagaaggct gcctgccgca ttttccagcc aggttgccgc cgggaactga 939781 ccggtgtgta tccataagtt taatccgtat cggaggcagg cgccaagcgc gcctccgata 939841 aaaaccgcgc tatatatttt catgtttgcc atcctttatg atgaaatccg ggtaatctgt 939901 aacgatgccg tccacgccca tggcttgtaa ttttgccgct gtcttttgat tgttgacagt 939961 ccatgcaaat atgtttaagc catttttatt gatggagccg atcatcagac ggttaagccg 940021 tgtgtgtttt atattgacat agtttgcaaa agagcggaag gccttcatct gatttctgga 940081 cagcatgcca aagttgggcc ttgtaatgac cgctgtcgga atcgaaggat aaagctcgcg 940141 gaacctttgg acggagcgga actgaaagga ttgaacaata ttattgatag aaaaagaaaa 940201 ttgccctaat agctgtccca cctcttcttc aattccgact tgagacggat ggccttttag 940261 ttcaattaaa aggccgattt ttttgtggta gcgcttgagc accgcttcca gggttggaat 940321 acgctctcct tgaaaagcgg gaccgtacca gcttcctgca tcgagttttt gcaattcctc 940381 caaggtaaaa tccttaacaa agcccgatcc gtttgttgtt cggtcaaccc tgtcatcgtg 940441 tatcacaaca atctgcctgt cttttgtaag ctggacatcc agttcgatca tatctgcatt 940501 cattttcacc gcaaggtcaa atgcggcaat cgtattttcc ggagcgtagc cggatgctcc 940561 gcgatgggca atgatgtaca agctaagtca gctcctcgta tgggcatttc tgttattgta 940621 tcaaatccat atatgcaccg cgatacaaac tggtgaattt tttctgccat atcggaatgg 940681 tccgggctga ggaatgcgta taactaaaaa aagacactca gcgtatcaga acacatttcg 940741 tcagaaaatt aggtctttcg acatgttcac aacaaaatat gatcctttat aatagcaaaa 940801 aaggaggcga gatcatggga aaagggagaa tcagagtgga ggaaagaatt aaagccgaaa 940861 cggatgctga aatgcaaaaa gcaactctcc ttgatcagac acaaacgaaa aaaggtaagt 940921 gactgtccct attgaatctg gctgatagat gaattgagaa atgaccccgg cgtttcgccg 940981 gggttttgtg ctgcataaga catttaaatg aacatcctta cgaatatttt agtataataa 941041 acaattgatt gggatagagg ggagacagtc atgccggatt atctgcagca gtattttacg 941101 cttgataaca tcatacaaat cggcatcagc ttggcgattt tgctggtgtt tcttatactt 941161 agaaaattat tcacaagata tttttttaac ctgcttttta atttgacaaa ccggccgaaa 941221 acagaaattt ttaaacaggt ggttctggcg tttgataagc cggccagatg gttttttgtt 941281 gcccttgggc tgtttttagc gatccggtat tcaccgtttt tagatgagca aatgccggtc 941341 atcagcaaaa tataccgctc actgattgtg gcgctcttgt gttggggtct ttgtaatttg 941401 accgcaacat cgtcgtttat cttccataag gtgaaccagc gcttcgagct tgacatggat 941461 gacattctgg ccccgttttt atccaaattg ctccgttttg tgatcattgc gctcagtgtc 941521 agtgtgatcg ctcaggaatt caattatgat gtcaacggat ttgtagcggg ccttggtctt 941581 ggcggactgg cttttgcgct tgccgcgaag gataccatca gcaacttctt cggcggtatt 941641 atcattatta ctgaaaagcc gtttacaatt ggtgactggg tggagacgtc gacagtaaca 941701 ggatcagtcg aggatattac ctttaggagc acgagattca gaacagcaca gggggcgctt 941761 gtaacggtgc cgaactctac gctgtcgatg gaagcgatca cgaactggac aagaatgacc 941821 aaacgccaga ttacgttttc catccatgtg tcctacgcta cgccgattga gaaccttgaa 941881 cgctccattc attctctcag aacaatgctc ttagagcatg agggcgttga taatgaaata 941941 atcatggtca actttgatac gtttgccgac agctactaca atttattttt taacttctat 942001 acaaaaacga cggtttgggc tgaaaacctt aatattagag aggatatcaa ctataaaatt 942061 attgagattt taggtgcaga aggcgttcag tttgcatatc ccggccaaat ggttgttgtc 942121 aagcaaaagc acgaaagcga ccaattccag gtgaatctaa ataaagagga aaaggaacgg 942181 gcttaaaaga gagacttcgt ctgacagagg cggagtcttt ttcatggtaa aataagagaa 942241 aaaggcggtg ttgagttgga aacattcaaa agtattctac atgaagcaca gagaattgtt 942301 gtgctgaccg gagcgggaat gagcacagaa tcagggatcc ccgactttcg ttcagcaggg 942361 ggcatttgga cggaggatgc ctcaagaatg gaagcgatga gccttgatta ttttttaagt 942421 tatccgcgtc tgttttggcc caaattcaaa gaattgttcc agatgaaaat gagcggcagc 942481 tttgaaccga atgaaggcca tttgctttta gctgagctgg agaagcaagg gaagcaggtc 942541 gatattttca cgcaaaacat tgacggtctt cataaaaaag cggggagcag gcatgtgtac 942601 gaactgcatg gttctatcca gacagcagct tgtccggcat gcggcgcccg atatgatctt 942661 ccccatttgc tggagcggga ggtgccggag tgcacggcgg ccggaaacaa tggggacatt 942721 tgcggaacgg tattaaaaac cgatgttgtt ctctttggcg atgccgtcat gcactttgac 942781 accctttatg aaaagctgga tcaagcagat cttttattgg ttatcggcac gtctctcgaa 942841 gtggctccgg ctagatttgt gcctgaggat gcaagcctga ttcccggcat gaagaaagtc 942901 atcataaacc ttgaaccaac gtattgcgac agcttgtttg acatggtcat ccatcaaaaa 942961 atcggcgagt ttgcccgaag tttgggcatg aaaaagtgag ccgctttatg cgcctcactt 943021 ttttattcat gaacaggaac cattgtgtcc tctaacactc cgaaggaata gcctttttct 943081 tttaatttat tgattagtac cggcagcgca tttacagtag caggaagatc atgcatgaga 943141 attacatttg ggcggcttga agagctgtgt tccatattct caagctgctg taatacggcg 943201 gtcacatact gtgaattccg gtatttccag tccatgctgt cgatcgtcca atcccagtac 943261 acaaacccat ctttctccag attgcgaatt tgtgaggcgg ttagtgacgg cttgcttccg 943321 tatggcgttc tgacaagatc ggttttatat cctgtaatgt cctgcagcgt gtcacgcgcc 943381 tcctgcattt cttttagcgg agatgtcggt gtttgataga acaatctgtt attgtgggta 943441 acgccatgta aaccgagtgc gtggccttcc ttttctgctc ttttcacagc ctgcttgaat 943501 tcgttcatcc gcggtgacag cataaaaaac gtcgctttta catcagcgct tttcagtacg 943561 tcgagcaagc gggttgtaac ggctgaaggg ccgtcgtcga aggttaagta aaccgtttta 943621 tctcccatgt tctgctttgt ctgcagatgt tttatcagga gatcggggga gtcgtttttc 943681 agcttaaggc tttccttctc atctcgaagc tggccgtttg ttgtgacagt gacttccttt 943741 gctttcgttg aactgttgga ataacccaaa atcaccataa gcaaaagcag cacacataaa 943801 actgctaaac ttgcaaattt aaaagcaagc gaaactgcag aaggagaagc ctctcctctc 943861 gtttgtcgca taacaatctc tccattggca taaaatctct acataatgct gtacagcagg 943921 cagcttatga agatgcctta tgtttacaac ctatgtatta ccagtcaagt atacaggaat 943981 aaaactggaa agcacataga aaatttgtcg aaatgtcaga ttttaaggaa aaaataaact 944041 cctttccgct atagatctct tgatctttct gtttttcagc ttgtccaata tggtagaatt 944101 agtgataatg acagcttgaa tgacatcagg gacatctcga aaagggaggg cttttatgaa 944161 ggttttagtc aatggccggc tgattgggcg cagtgaagca tcaatcgatt tggaagatcg 944221 cggttatcag tttggtgacg gcatctatga agtgatcagg gtgtacaaag gagtattgtt 944281 cggcttacgt gagcatgcag agcgtttttt cagaagtgct gctgaaatcg gaatttcact 944341 gccattcagt atagaagatc tcgagtggga cctgcaaaag cttgtacagg aaaatgcggt 944401 cagtgaggga gcggtataca ttcagacaac aagaggtgtg gccccgcgaa aacaccagta 944461 tgaagccggc ctcgagccgc agactactgc ctatacgttt acggtgaaaa aaccggagca 944521 agagcaggca tacggagtgg cggccattac agatgaggat cttcgctggt taagatgtga 944581 tatcaaaagt ctgaatttac tgtataatgt catgacgaag caaagggcct atgaagccgg 944641 agcatttgaa gccattttac ttagggacgg cgttgttacg gagggtacat cctctaacgt 944701 ttatgccgtt atcaacggca cagtgcgaac acatccggct aatcggctca ttctcaatgg 944761 aattacacgg atgaatattt taggactgat tgagaagaat gggatcaaac tggatgagac 944821 tcctgtcagt gaagaagagt tgaaacaggc ggaagagatc tttatttcgt caacgacggc 944881 agaaattatt ccggtcgtga cgctcgatgg acaatcgatc ggaagcggga aacccggacc 944941 ggtgaccaaa cagcttcagg ctgcttttca agaaagcatt caacaggctg ctagcatttc 945001 ataaatgaac gaagaaaaga gcccgctttt tacagcgggg ctctttttat tttttaacaa 945061 atccaatcaa aatggagatc attggcgata tatagaggaa gaacgtaaat gggatgtagt 945121 ctatgactgg aacaccaagt gcgctcgcca taaatgcgcc gctgacgccc caaggaatca 945181 atgggttaat taatgttccg ccgtcctcta atgatcttgt cagaaatttt cgctggatgt 945241 ttcgtttgtc atataaagat ttaaatgatt gtcccggtat taatatcgat aaatactgtt 945301 cgcccgttgc caagttgacg ccgatgcttg agcagacagt tgctgcaaca agacggcctt 945361 ttgagcggat gcctttcatg acgccttcca atagtgcaga aatcaatccg attttctcca 945421 tcaatccgcc gagtgcaaaa gcaatcataa tgagagagac agagcccatc atggattgca 945481 gtccgcctct gttaataatt ttagcggctg cctcattgtc agtttcgaaa gttgtgccat 945541 tttgtaaagc tgtcataaac gcctgcaggc tgctgtaggg tacaaaaata gcagtcaaaa 945601 ttcccgagga aataattccg gcagtcagaa cggggattac tgatacccgt ttcattgcca 945661 gcaaaacgac taagagcgga gaaagaaggg cccacggtgt cacgtttgca gcatctttta 945721 ttccggttat gacctgctga atattatcgg ttgaagcagc gtccgctgac actgatgaac 945781 cgagaaagta aaacagaacg acagtgatga gcaaagctgg aatggttgtg cccatcatat 945841 ggcgaatgtg ttcaaagatt ggtatttcgc ctattccggc tgcaaagttg gttgtgtccg 945901 acatcggcga cattttatcc ccaaaacaag cgccgcatat gactgcgcct gctgtccatt 945961 caagcggaac gccagccgcg ctcgccacgc cgatcagcgc tactccgatt gtgcttacag 946021 ttgtcagact tgagccaaca agtgtgctga tgatcataca tgaaaacaaa gcagtcaaca 946081 gaaggtggct tggttcaata aaggataggg cataaactgt catagtcggt attgcgccgc 946141 tgtacatcca ggcgccgatt aagatgccga tcagcgctag aacaataatc ggctgtacgc 946201 cgtttttgat cccgtctaca atcccttttt caatgctctt ccagggaaat ccaaaccata 946261 aagctgctgc tgaaagcatg acaacactta aaaacagcgg gatatgaggt tctacatgaa 946321 gcaagaataa gcaagaaata ataatgcaca acatgaatat aaataaaccg acggctaacg 946381 gaaacgtcag ctttttttga gaatccaaaa taacacccca tatttatctt taatgctttt 946441 gtgcttttgg gcacgaaagc attataacag aaaaaaacga aaatctatgt tttttcacaa 946501 ttatgaatat aaaagaagtg agcacagggc gtgctcactt tacaatcagg acgggtatat 946561 ccgatttcgc tgaaagcttt tcacttacac ttccgaatat tagctttttc agcctgtttt 946621 ggtctctgct tccggttacg atcatatcgg cagaaatgcg gtttgcatgc tcgataattg 946681 attcagccgg atcgccttct aatatatcga tatctccatc tgcctgctgt tcattcagca 946741 tcattctggc ttcggcgatg acttcttccg tacggtcttc atagatcatt ggctcaggtg 946801 atgttacatc cgatatcagc ggatcaggaa cacttgtcat gcctccgctg atatagcttg 946861 cctcagctgc gggtctgggc gggtcgatga cggtctgatt gtctttcata tcatgtgaat 946921 gggcgacggt aatagcggca tttacggttt tagcaagatc aatggctgtc agaagcgctt 946981 tcttactatt ttcacttccg tcaaacgcaa caatgatacg gtcagcatgg aacatccttc 947041 tcaccctttc aaagcgtctt acaacactac tacccgaatt tgagcacaat taaccttttc 947101 ctattcaagt aatgattgac aataaaaggt tttgtttata tgatgataaa aagatgaaat 947161 cagaatggaa ggagggtttg ctatgccaag gaatttgcgt gtttatcaaa cagtttcata 947221 ttggcgcggc aaaccttttg ttctgttttc gtgaacggtt ttttaggtcg gaccgcgcgc 947281 tgaaaagcgc tgtgcgtaac atatcggtta aaaaaggcat ggagctgacg cttcatgcct 947341 tttttatata caaaatctaa ggaaagacag gtgtatggga tgtgaagaca aatacagagg 947401 cgagggcagt tcgtgccaaa ctggatgaaa aaagctgcaa ggaaaaaata gaaggcggct 947461 gatgaggaga tggggataga tgttttcagt tttgaaaaag cttggctggt tttttaaggc 947521 gtactggctg cgctatacga ttgcgattgt ccttttatta gcagtcaatg tcattgaaat 947581 gtttccgcct aagctcttgg ggaacgccat agatgatatg aaagcagggg catttactgc 947641 ggaagggctg ctgttttata tcggtatctt ttttgtgctg acggcggccg tgtatatcat 947701 gtcttatttt tggatgcatc agctgtttgg cggagcgaat ctgatggaga aaattcttcg 947761 tacgaagctg atggggcatt tgctgactat gtcgccgccg ttttatgaaa aaaaccgaac 947821 aggcgattta atggcacgag ggacaaatga tcttcaggcc gtcagtttaa ccacagggtt 947881 tggcatcttg acgttagttg attctacgat gtttatgatg acgatctttt tgacaatggg 947941 gtttttgatc agctggaagc tgacctttgc cgccattatc ccgcttccag tcatggcgat 948001 tgcaatcagt ctatatggaa gtaaaattca tgagcggttt actgaggccc aaaacgcgtt 948061 cggggcgctg aatgacagag tgctggaatc tgtttcaggc gtgcgggtga ttcgcgcgta 948121 tgttcaggaa acaaacgatg ttcgccggtt taatgaaatg accgctgatg tttatcagaa 948181 aaatatgaaa gtggctttta ttgattcact gtttgagccg acggtaaaac tgcttgtcgg 948241 cgcaagctat ctgattgggc tcggctacgg agcgtttctt gtattccgga acgagctgac 948301 gcttggagag ttagtgtcct ttaacgttta tctcggcatg atgatttggc cgatgtttgc 948361 aatcggtgaa ctcattaatg tgatgcagcg cggcaatgcg tcattagatc gggtaaatga 948421 aactctttct tatgaaacgg atgtgacaga tccaaaacag cccgctgatc ttaaagagcc 948481 tggagatatc gttttcagtc atgtcagctt tacatatcca agctcaacaa gtgacaatct 948541 tcaggatatt tcatttacgg tgcgaaaagg gcagactgtc gggattgcag gtaaaaccgg 948601 gagcggaaaa acgacaatta ttaagcagct tttgcgccag tatcctccag gtgaagggag 948661 cattacattt tcaggtgtac cgattcagca aatccctctt gaccgtctcc gcggatggat 948721 cggatatgtg cctcaggatc atttactgtt ttcacggact gtaaaagaaa atattttata 948781 cggaaaacag gatgcaactg ataaagaggt tcagcaagcc attgccgaag cacattttga 948841 aaaagatttg cacatgcttc cgtccggtct ggagacaatg gtcggtgaaa aaggcgtggc 948901 actgtcaggc gggcagaaac aaagaatttc gatcgcgaga gcactcatgg cgaatccgga 948961 aatcttgatt ctggatgatt cactttccgc tgtagatgcc aaaacagagg ctgcaattat 949021 caagaacatc agagaaaacc gcaaaggaaa aacgacattt attttgacac accgattatc 949081 cgcggtagag cacgctgacc tgatccttgt gatggacggc ggcgtcattg ctgagagagg 949141 cacgcatcaa gaactgctgg ccaataatgg gtggtaccgg gaacaatatg aaagacagca 949201 gctgttcact gcggaagaag ggggagcagg ggcatgaaaa taggaaaaac gttatggaga 949261 tacgcacttc tttatcgaaa attgctgatc acagccgtcc ttttgctaac tgttgccgtc 949321 ggtgcagaac tgactgggcc ctttattggc aaaaaaatga tagacgacca tatcctcggc 949381 attgagaaaa catggtatga agctgcggaa aaagataaaa atgccgttca gtttcacggc 949441 gtctcatatg tcagagagga ccgattgcag gagcctgttt caaaagcaaa agaagcgcat 949501 atttatcaag tgggaatggc gttctatttt gttgatcagg ctgtcagctt cgacgggaat 949561 agaacggttt ctgacgggaa gctgacgatc acaaacggag acaagagccg ggcatatgct 949621 gccgaaaagc tgactaagca ggaacttttc cagttctatc agccggaaat aaagggaatg 949681 gtgttactga tctgcctgta tgggggcttg cttgtgtttt cggtattctt tcaatacgga 949741 cagcattatc tgctgcagat gagcgccaat cggattattc aaaagatgag gcaggacgtg 949801 ttttcgcaca tacagaaaat gccgattcgc tattttgaca accttccggc cggaaaagtc 949861 gttgcgcgga ttaccaatga tacggaggct attagggatt tatatgtcac agtgctttca 949921 acatttgtga caagcggaat ctatatgttc gggatattca cggctttgtt tctgcttgat 949981 gtgaagcttg cgtttgtatg tctggcaatt gtgccgatta tctggctgtg gtcggtcata 950041 taccggagat atgcgtcata ttacaaccaa aaaatccgct cgatcaacag tgacattaac 950101 gcaaaaatga atgagtcaat tcaaggcatg accattattc aggctttccg ccatcaaaag 950161 gaaacaatga gagaatttga ggaattaaat gaatcacatt tttatttcca aaacaggatg 950221 ctgaatttaa actccttaat gtcccataat ctggtcaatg tcatccgcaa tcttgcgttc 950281 gtctgtctga tctggcattt tggcggtgcg agcctgaatg cggcggggat tgtttctatc 950341 ggtgtgctgt acgcgtttgt cgattatttg aaccggttat ttcagccgat cacaggcatc 950401 gtcaatcagt tttcaaagct ggagcttgca agggtctccg ccgggcgtgt ttttgaactg 950461 cttgaagaaa agaatacgga agaagcgggt gaaccggcga aggagcgcgc gctggggcgg 950521 gttgaatttc gtgatgtgtc atttgcgtat caagaaggtg aagaggtatt aaagcatatt 950581 tcctttactg cgcaaaaagg cgaaaccgta gcgctcgtcg gccataccgg atcaggaaaa 950641 agctcgattt tgaatcttct gtttcgtttt tatgatgcgc aaaaaggtga tgtcttaatt 950701 gatggaaaaa gcatttacaa catgtcaaga caggaactca gatcccatat gggtattgtg 950761 cttcaggacc cgtacttatt ctcgggcaca atcggatcta acgtaagtct ggatgacgaa 950821 agaatgactg aagaagaaat aaaaaatgca ctgcggcaag tcggtgctga gcctcttctt 950881 aagaagcttc cgaagggcat taatgagccc gtgattgaaa aaggcagcac gctatcctct 950941 ggagagcggc agttaatttc tttcgctaga gctttggcgt ttgatcccgc gatcttgatt 951001 ttagatgagg caacggcgca tattgataca gagacagagg ccgtgatcca gaaggcgctt 951061 gatgtcgtca aacaaggacg caccaccttc gtcatcgctc accggctttc aacaatcaga 951121 aatgctgatc agattttggt tcttgataaa ggagaaattg ttgagagagg gaaccacgag 951181 gaactgatgg cattagaagg ccaatattat caaatgtatg aactgcaaaa gggacagaaa 951241 cattccattg cataacgctc aaaaacccaa aacaatcgtg ttttgggttt ttggtttatg 951301 tagtcaataa gccagtccga cacggtttcc gacatactca cctgtaacga gctcacgata 951361 taaaaagtcc gcagtatcgc cgaccgaaat gcttgtgccg ccctcaggca aaacgttacg 951421 ctccgtacga taaacgccgg ttgctgttcc gtccgggagg taagtggggc agatgattgt 951481 ccagtctaat gatgattctt taagcatttc gtatactttt gcatgctcct tggctgcgcg 951541 ggtctgcttt cgtttcgatt catttgtttc aaaccggtat tttcccggtt catatcggga 951601 atctaggatc cctgcggtgc cgatcgtaat aagccgtttg atatgctgtt cctccataac 951661 ggagagaatg tgtgccatag cagttgacaa ggtatcatca ccatctgtgc ctagacagct 951721 gatcacgatt tcagcattct ccattatttt tttcacatct tctaagcggc gggcgttccc 951781 catgacagtt ctgtcttttg aaaggggaag atcagcatgt tgagatctga tcagagcgaa 951841 aatatcaaat ctttcatctg ctgcagcttg tgttaaaaag gcttgtccga cgcggccgct 951901 ggctcctaat aaagcgattt tcattaaaaa acctcctcgc ctttcattat aaaaggatgt 951961 tctcagtttg aacagcgcgg gaaagaatac ctgtacaaat aaacagaacg atgggaaaca 952021 tattcatgaa tcatggatac acttacgaat tgaaccagct cccaattcac aatggtgatg 952081 aatgacaccc cgattccctc cctttttttc taggatatgt ggagcaggaa aaaagggtga 952141 caaaataaag agagcgcgga aaccgcgccc tctatagcca tatattgaat tgttattgaa 952201 ctctgccgcc catttgctgc tgagcgaaag atactaaacg ttttgtgatt tctcctccga 952261 cagaaccgtt agcgcgagaa gttgtgtccg ctccaaggtt aacgccgaat tcagaagcga 952321 tttcaagttt catttgatcg atagcctgag ctgcgccagg aactagtaag tcatttgaag 952381 agttttggtt agccatgtgt aaaatctcct ttttatttag tatggttggg ttaactggag 952441 ttgcaccaat ctgtgaaccc ttctcgggtg tcactgccgc ctcggcgtaa cccaatgctt 952501 tgccggcttg ttactacgta ttatgttaaa atggccggaa aatcatgcgg agaattgtgt 952561 ggtaaatctt gagaaataaa aaaagcttag ccgtttaggc taagctagtc ataaatatga 952621 aaaagcatca gttcatgtat ctcgtttgta agagcaggct cgtcagcgcg ggcgggaaac 952681 aagtctcccc attcaatctc accgctctta tgatagatgc cttcataatg ggtcccttta 952741 taataaaatg aaattttcca tccgggcagc ttttcttttg ggaacaaagg tttccagctg 952801 aaatgagaaa tcattacggc cacgctcctt acatttggta tcaattgacc taaataaaaa 952861 cggcttatgt tcattgtatc attgtttcag aacatcattg aagaggccta aatatgcagt 952921 ttgtcccagc tttggataaa gataagcccg ctttattaaa aaagcggaca ggttacgaag 952981 gccacaatgc ttccggagat gtgattgcct tctcagataa atatgacgcg tattcaaaac 953041 ttcttcgttt tgtaagagaa tcaacatgat gcaaatttgg atgagaaaaa atgcttcggc 953101 ccgggcgcga attcgcttca aacatccata ctttaccgtt ctgatcaatg ccaaaatcga 953161 aaccaatctc cccgataaat ccctcgatat gatcatgaag gacatggctt gcagtcagtg 953221 ccgctgcaga aagcttttta atgacctcaa ctctttcagc gggatcatcg tatacttccg 953281 caagtgtctt tacagtgccg ccgttagaaa gatgtgttgt aatgctgttc tttccggaaa 953341 tttttacggc gattgctgtc actgtccatt ttccttttct gtttttattg gtatggacac 953401 ggaaatccgc tggtttgcct tgaaattcga tgagatcaac accttgctga atgagaaagt 953461 cggacgggtt gtgatgtttt tgaaattctg caaggaatga ggcggcatcg gaataatcaa 953521 ttgatgtaaa agttttggcg tcattcgtat gctttaccgt caggccgcca tctgttcttg 953581 tcagctgata aatgccggtg ccgagtgctc catttgccgg tttgatatag acttttttgt 953641 atgcgccaca gagctcatct atcagctcca cagacggtgt cagctcggat ctaggcaaaa 953701 agggtgccgt tcttggatct ttttcgagca attgatgaac gttccattta ttgaaaaacg 953761 ttttattaaa ccatgggatc tgatattcat cgatcagcct cttttttgta tgttgcaaga 953821 gaagtgaatc ttcaattttt cggttcggca aacggtcata aacgacgttc ggcaatggaa 953881 cgattttttt ctcccagccg ttttccctgt aaaggaggcc ttcaatcgtg ccttcctccc 953941 aattgatttg gtgcgcgcca aaaacgaagc agtagccccc ggcttgctcg tgtaacgtga 954001 caagtttaga aaaaaagagg gaacgatcct taaatgggcg ttcaagagat acagtaaacc 954061 ctgccgtaaa gatgccgact aacggcccga tatgcactgt atgatcatga atcagtatat 954121 ctgccctgct tcggtgggga agcaaaagct catgaaacag attttcagag agaagcacgg 954181 tttgttccag atgccgtctg taagcaacgt ggcatctgac aaccttcgtt ccgaatgcgg 954241 catgcaaaag tccgtcttgc ttcagcgaag agggcagaaa cagggtgttt tcactggttt 954301 tgtctatgcc gatcaaaaac cgtttaggat tcacgcggaa gaactccttt ctggctttgc 954361 tcagaaaaca gatattggca gcgttttagg ggacaagtgt acagctgttc tttttgctcg 954421 ggagagacac gcaggattga cttcctgcct ggtttggaat tgatatctaa aatccaaatt 954481 ctcccgtcct ttgcaagaca tatatcaaga ccgagttcaa acaacggccc atagcgctcg 954541 tcaagataat acggaaccga ttgggtaatt gaaaacacat catctagtaa aaccacttgc 954601 tgttttttcg gtatatcttc aaaccaggag tcaaatgtca gcgcatcaga tccgcctgac 954661 aaattggcca gcagcccgtg tttgtatccg cgtcttactg cctttccgac tgtattccat 954721 tcacctgctt cgtttttttc cataaacaga cgaatatcac aagggtattg ttccttatct 954781 tgaatgttta agtaaggctg aagcaaatat tgatgctgaa gcactttttt gcaccatgtt 954841 ttaaaagaag tctggttgga aaacgttttt gtctgcttat cctttccgat gtgataagta 954901 gcagtgatgt ttttcttgcc cagcttcaaa agaatcacgc ctctgcctcc cgcgccgaat 954961 gccggtttaa ggatgcaggc tttttctttg gataaaaagg agtgaatttg ttcgtagcgg 955021 ctcaccttta tcgtttcggg aatataggga ttgattacag agtgctgctg caaatcgtga 955081 aggacggtcc acttatcggg aagaccccgc ccgataaatt ccgttttcgg atattttttg 955141 agccactcaa cgattggttt tgctttttgg gaatgtgaat ccttgccgta aaaacagcga 955201 tcataaatat aatctggaat cgccatttca gtttcgttcc atgtgctgct ggccgaatga 955261 tagaccgatg ctttgacacg caaagtgtca ggtgaaatat caaatggtgt aaaccggatg 955321 aaacgtatgc cgaattcggg tgctcttttg gccagttctg cggaataatc cgcttcatgc 955381 tggcgggata aggacataaa accgagtgtt atcatggtga gactccccct tttattcaaa 955441 agctgccggc gggtgtccgc agctttacac taaatacatg taagacgaac gcagctgacg 955501 gtattctact ttacagaata cgattctcca ccttgcccta ttccaaaaga acaagctgat 955561 tttctaagaa caggaatttg tctcctcgtt tgctaagtga ttgcatgagc ctctataata 955621 cgtataggta cataatctat atgaaaaaag ctgaagcaca gatggaggaa gatgaatagg 955681 aatgggtatt gcaggaacct ttatttttat gatcgtgatc ggcgctgcca ttggagcggt 955741 gaccaatcat ttagcaattc aaatgctgtt taggccgtat aaagcgtact atttgtttgg 955801 gaaacgagtt ccttttacgc ccgggctgat tccaagacgg cgagatgaac ttgcaaaaca 955861 aatgggactg atggtagtca atcatctctt aacccctgaa ggcattaaaa agcggctcgt 955921 ctctgatgca gccaaaacgc aggctcttcg agtgggggaa cagctgattc aaaagctgtc 955981 actttctgaa gtgacagtaa aagaagcgct tgaaaaagcc gggatgaagc gccccgaaaa 956041 agctgctgat gcatggatca gcagctggac cgatgataag ctgcatgagc ttttccgcca 956101 atacggggac caatcgttaa aagagctggt gcctatagag gtgcaggaaa agcttgagga 956161 aaaaattccg atgatttcag gatatatatt gtcacggagt gtccgttatt ttgaaagtga 956221 tgaaggaaaa atccgtcttg gcaatatgat tgatgacttt ttaaaagagc gcggcatgct 956281 tggaagcatg gtgcaattgt ttcttggcaa ttcaagcctt gcggatcgcg tgctgccgga 956341 gctgctgaaa ttcttgcgca atgaggaaac aaataaattg ctttctgatc tcttaaaaaa 956401 cgaatggggc aagctgaggg agtatacgtt taatgaagca gatgaaaaat ggaatgcaaa 956461 ggcgctcatt ttcagtttga aacgaagagt gctgcaagca ttttcgactg cccctttctt 956521 caacaatacg attggcacgc ttaccgtccg ctatgaatct gagctgaccc agcaaatgct 956581 gccggcacta ttagacaaat tgcttgaagg tatttcgtcc aaccttgaaa gtgtcttaaa 956641 acggttgcgt cttgaggaaa tcgtcaagga gcaggtggat cagttcccgg tggagcgtct 956701 tgaagaaatg gtgctgtcca tttcaaaaaa agaatttaaa atgattacct atttgggggg 956761 ccttctcggc ggaattatag gcgcgattca agcattgttt gtcatccttt tttaagaaga 956821 aatggttttt gattaatgaa aggagctcca tagtctgtta tagtggagtg gtatgtcaaa 956881 cggcaatgat gaaaggagct atttacaatg gctgttaatt tttatgatgt agcgtatgat 956941 ctggaaaatg cattacgcgg gagcgaagaa ttcacccgtt taaaaaacct ttacgacgaa 957001 gttaacgcag atgaatcagc gaagcgcatg ttcgaaaact tccgtgatgt acagcttaga 957061 ctccagcaaa aacaaatggc aggagaagag attacacaag aagaagtgac gcaggctcaa 957121 aaaacagttg cgcttgtaca gcagcacgaa aaaatttctc agctgatgga agcggagcag 957181 cgcatgagca tgctgattgg tgaattgaac aaaatcatta tgaagccttt agaagagctt 957241 tacggcagtg ttgaaggcta ataagcaaaa tcccttcttg gataagaagg gattttttat 957301 tcactcagca aacttggaaa tccaatgaat cttttacctc tccattgatg atgactgata 957361 atgtatgaat tcctttgtaa tgctttctgg tggttaaatc cttaaaggat tggattcttg 957421 tgtatgactt cgtttcgttt tttcgtatat ttgtttctgt tattttaaat actttctgat 957481 gacgctggcc tcttgctttt acaaaatcaa ttgcgtactc aattcttact ttttgatccc 957541 tgtctgaatg aatatagaaa gaaaattcaa ggctttcgcc aataactata cgtttgggct 957601 ggcatgttaa atcatgtagt tgtatcgaat cagcattttc ataaccaaaa agcgctaagg 957661 cctgtttatc accctttttt aataaggtcc gataggcgtg tttgataatc cagtctgtat 957721 ggggatgtgt tccgtaccat tgatctgcga cttttctcag taaatgagga tgcgtttttg 957781 atatatcatt aaggttgttg gccacgcttt ttcttacata taaagactcg tcctgcatca 957841 gcttctcaag gatcggcaat acgggggaag ggtccgattt caaagccggt atcgattttc 957901 cccatggcag gcggggcctg ctgccttcgc tcgcaagtct tctcacgtgt tcatttttat 957961 gctcagacca tgcaagcaat tgtgcaatca tcttttcttg atctaacagc aaaaaaggcc 958021 ttacagcaaa ttctgaggtc gaatattgcg taaaggattc caatgccttt attgattctt 958081 cccaatgcgc taacccgtac tgttccacat aatctggaaa taaaattccg ctgagtcctt 958141 taaaatgagg ggctgtatcc cgtaaaattg tgagcgcttc aacgtattgt tttggcaaag 958201 tttcgtataa agaaactgtc acgcggcgca tccgctcttt taaagtgagt tcaggccagt 958261 cctccagccg taatgtatcc aagaatctgt ttttgttaaa atcaggatag gatgacctta 958321 catgatggat caactgagat atcagttctt cattatatat ttcttttaaa tcagccatat 958381 aaacaccgct ttttcgttta ttatttatat tgtatgggaa tgtacgttct ggatcaagtg 958441 tatagtccta aaaattaaca actgatccta ccacggatat acaaaagttg gttacttttt 958501 ttagttaaaa aaacccttgt catcggaaag gaaaactgag ataataacat tgaaagcgcc 958561 tacacttacc tatttcaaat ggatacggtc gcatatcatg ccgttatata gaggggataa 958621 gcaacagaga gtaagtgttc ggagcgcatc attggtcaaa caaggggttc ctgatacatg 958681 atttttcgta aatcgaaata acgatattag ggagaatggc tgcttcgatc gtatcctatc 958741 aacaagccat acataaagtc tgctgagcca ggcttttttt gctttaagaa aaggttgttc 958801 taaacacaga gacagggtca tatcctatac acaagtacag tcatcaagga gggggacatc 958861 tctgtgtcaa aacaattgct tgccttaaat atagatggag cgctgcttcg gtcgaacggg 958921 aagattcatc aggcaacgaa agacgcgatt gaatatgtaa agaaaaaagg gatttacgtc 958981 acacttgtga ccaaccgtca ttttcgctca gcacagaaaa tagcgaaatc gctaaagctt 959041 gatgccaagc tgatcaccca tagcggggca tatatcgctg agaaaattga cgccccgttt 959101 tttgaaaaaa gaatttctga tgatcatacc tttaacattg ttcaagtgct ggagagctat 959161 caatgcaata ttcggcttct tcacgaaaag tattccatcg gaaacaagaa aaaggtgaat 959221 tcgaatttat tagggaaagc actcattcat ccgtctgacc cgatctttta tccagtccag 959281 ttcgttgaat cattaagcga tctcctcatg gatgagccgg tgagtgcacc cgtcatcgag 959341 gtgtacacgg agcacgacat tcagcatgac attacagaaa cgattacaaa agccttccct 959401 gcggtggacg tgattcgcgt aaacgatgag aaactgaata tcgtcccgaa gggtgtctcg 959461 aaggaagcgg gtttggccct cgtcgcttca gagctgggcc tgagtatgga tgatgtcgtg 959521 gccattgggc atcagtatga cgatctgccg atgatcgaac ttgccggtct tggggtagcg 959581 atggggaatg ccgttccgga aattaagaga aaggcagatt gggttacaag gtccaatgac 959641 gagcaaggtg tcgcttatat gatgaaggaa tatttccgaa tgcagcagcg aaaaggattt 959701 cttgataagt tccacatgaa acgtgtgtaa aaaagccgct cgcgccctga caggtgcggc 959761 ggcttttttg ccggattgat tttagcagtt tatttctgta cactaaagaa agttttgaat 959821 ctgataaatt aggtgatgaa gttgcaaatt aaaatagaag gcatacatga tgaccgcctg 959881 catcggcctc tgcaaaatat tgcaaatttg ttttatgaag agtgcgagct tgcgtatggc 959941 ggagaggagc ccgcagattt tgtcatttct ttagcgttgt cacaaacgga tgagcatgtg 960001 acggtttctg gagaagtgaa gggtactggc ataaaggaac agcatacaaa attcttttct 960061 ccagacatga ctgaaaaaga agcttttaag caagtgaaaa acacaatttc ttatgtgtat 960121 ctcaatcttc ttcaggcgca tacgggcatt acgcagaagt ggggaatcct cacaggaatc 960181 cggcccacaa agctgcttca taaaaaactg caaagcggaa tgtccaagga gcaagcgcat 960241 gctgagttga aaaaagacta tttaattcat gatgaaaaaa tcatgctaat gcaggaaatt 960301 gttgaccgtc agctggcggc agtgccggat ttgtaccgag taaaggatga agtcagcatt 960361 tatatcggca ttccgttctg cccgacaaaa tgcgcgtatt gcacattccc tgcgtacgct 960421 atccaaggac aggcgggcag agtcggctca ttcctatggg gactgcatta cgaaatgcag 960481 aaaatcggtg aatggctgaa ggagcatgat gttaaggtta caaccattta ctttggcggc 960541 gggacgccga caagcattac agcggaggag atggatctgc tgtatgaaga aatggtccgc 960601 tccttcccgg atgtgaaaaa cattcgtgag attacggtgg aggccggtcg tcctgacacg 960661 attacagaag aaaaactcgc cgttttaaac aaatatgaca ttgatcggat cagcatcaat 960721 ccgcaatcct acgaaaacga aacgctaaag gcgatcgggc ggcaccatac ggttgaagag 960781 accattgaga aatatcatct gtcacgccag cacggcatga ataatattaa catggacttg 960841 attattggtt tgcctgggga aggcgtgaag gagttcaggc acagtctttc agaaacagaa 960901 aaactgatgc cggaatccct taccgttcat actctttcat ttaaacgggc gtcagaaatg 960961 acgagaaaca agcataagta caaagttgcc ggcagggaag aggtttctca aatgatggaa 961021 gacgcggtag cctggacgaa agagcatggg tacgtgcctt attatttata ccgccagaaa 961081 aacattcttg gaaaccttga aaacgtcgga tactctttgc cgggacaaga aagcatctac 961141 aacattatga ttatggaaga ggtgcagacg attattggca tcggctgcgg cgctgctagt 961201 aaatttattg atcgggatac agggaaaatt acgcattttg cgaatccgaa agatccgaaa 961261 tcgtacaatg agcgcttcga gcactacacg gacgaaaaaa tcaaatattt agagcagatt 961321 tttgaaaaaa cgacaaagca gcactgatta cagtgctgct ttttttatcc ctgttttttt 961381 gcgggctgaa cctcaggctt ccatttaaat accttgttca gcaagcggta aattcgtttt 961441 gattcctttg tgacaagcgg tcccaaaatc gccagaatga ggacatataa tgcggcaaac 961501 ggctttaatg tggccgacag tccgccggct atcccgagat tcgcaacgat aatcgaaaat 961561 tctccccgcg atacgatcgt cagcccgata ttcgatgaag ccttatgaga aagccctgcg 961621 cgtcgtcctg ccaccattcc ggcgataaaa tttcccagaa tggtcaaaat cactgcaccc 961681 aacgcaagcc aaaccgcttc accaagcgaa aacggatcga tgctgaggcc gaagctgaaa 961741 aagaacatcg caccgaagaa gtcgcgaaac ggaacaacga ggtgttcaat cctatcggaa 961801 tgctctgttt ctgaaaagac caaaccgagc agcagcgcgc cgattgcttc tgctacatga 961861 atcgtctctg aaaaaccggc gataaaaaag agtgctgcga aaatgacgat aataaacact 961921 tcgtttgagc gaatgtccaa cagtttgttc aacagcggcg ggagttttct tgctgcgata 961981 aaaaacagca gcatataacc gaaggcgatc aaaatggaca agagtgcact ccctacggat 962041 gtcgcatcac ctagtataag gccggaaaca acggacagat atacggcaag gaaaatatct 962101 tcaaacatga tgatgccgag aatcaattcg gtttccgggt tggcggttct ttttaaatca 962161 acgagcactt ttgcgacaat cgcacttgac gagattgtga tgacgcctgc gaggatgagg 962221 acttccagaa aggaaaatcc ggtgataaac ccgtaaagca gtccgaggct gaagttaatc 962281 aaaatataaa tcgtcccgcc gaccgcgatt gattttcctg atttgattaa cttcccgaca 962341 gagaattcga gtccgagata gaagaggagg aacagtacgc ccattcgccc gaaaaactcg 962401 atgatttcac tgctttgaat aaatgttaga tcaataatcc ccattttcgg cgcgtgcggt 962461 ccaacaagca ttcccagcac aatcagaaac ggaataatcg aaaatttaat tttattggcg 962521 atcacactgg cgattgccac aagcacaagt gcagttccga cttcaaatac aagatggtcc 962581 atcggggctc acacgccctc tccagaaaga aaatcgtgaa tcagtttctt cagatgcttt 962641 ctctcacctg agaggacaag ggtgtcattt tcttcaataa tcgaatccgc tccgggattt 962701 aggagctttt cctggttgtg tttgataatc gcaataacag tgacatcgta attctggcga 962761 acatcaagct caccgagtgt gcgtccgatc gatttggcgc ctttttcgac cttaaaccat 962821 tcaataataa gatcgctgaa ggccatttcg atggactcca gagcttgcgg tttatagacc 962881 atgcccccga gaatagctgc aatttgcctt gcttcagaat catccaatga aatatttgaa 962941 agaagctcat ccgggtcccg gtcattaaac cggtaaattt cccttcttcc gtcatcatga 963001 atgataatcg tcattttttc gtggcttctt gtttcgattt caaacttttt gccgatgccc 963061 ggcagatcgt tttctttaat attcaatgaa aatccctccg aatgtagtgt tggcagtatg 963121 gggtgagtta caaataaaac ttgagcaaat tatattcgga ggtaattaga ctggtatttg 963181 acagggacgg ccaaagcctt ttccagcctg tttatcagcg gttcgtcaag tggtttgaca 963241 gagagctgcc tgacagactg cgccagcggg ctgtactctt tgatcagctc agccgggtgc 963301 atgctgcccg gcgatggcgt ttttgccgat tgtgtttcct gcggatatga agacataggc 963361 acatagctgt cagtgcttgc ttcaaactgg gaaggcagaa ccacgtccga agggggaaag 963421 tacaccataa ataaacttaa cagaaaactg atcagcaatt tatccatgtt cctttcctcc 963481 cttctcatca agatatccct tctttttcac tatataaaac tttatgtttc cattcaaaca 963541 atatgcattt ttcagtatct attgaccttg aaaaataaaa aggtttattt ggggatggcg 963601 gggaatgtat aggagaaaga aaaaagtaag cgcatacatg gaggtgcttt taatggagtt 963661 tgttcaatat gcatgtaatg gggccgttgc agagattatc ctgaatcggc ctgatgccca 963721 tcacgccctg aatgaacaga tgctgtctga attgaaggag gcagtcgaaa tggcggctgc 963781 aagcgaggcg ctcatcgttc tcctgagagg aagcgggaaa ggcttttcgg ccggcggtga 963841 tatcaggatg atgacgtcag agcatgaccc tgaccaattt aaacggctga tggatacgat 963901 tgaggctgtc accctgaatt tatatcagat gaagaaagtg acaattgcag ccattcatgg 963961 tgctgctgcg ggactgggcc tgagtttggc gctttgtgcg gacattgtgc tcgctgaaaa 964021 aaacgccgtt ctcgcgatga attttatcgg cattgggctt gttccggacg gcggaggaca 964081 ttatttgctg aagaaaagaa tcggtgaagc aaaagcgaaa aaactgattt ggagcggaaa 964141 aaaactatct gcctcggaag ctgccgatat ggggcttctt gatgggacat ttgccggaga 964201 ccctgccgaa ggcgcaagac ccattatcga aaccctgttg gcctcccctc ttttggcgat 964261 gatcgaaacg aaaggtattt ttcaaagcct ccaaattgaa gaactgaaaa aagtgctatc 964321 ccttgagcgc agcgcccaag agagaatgag aaggaccaag gatcaccaag aaggaatccg 964381 tgccttttta gaaaaacggg agccgaagtt tcaagcgtaa cagatcagcc ggaaagctga 964441 tcatctgtga aacaaaatca gctttccggc tgcattgact aaacgatgag tatgactatg 964501 aagctctttt tcttttaaga gggcttcacc atgcgttttt gccgcttctt catgttctgc 964561 ctcgaattgc tcgtttacca gcgtgttccc cgaaggatca aatacggtaa ggaaataatc 964621 agccatcagg tttctcctcc attttaaggt ttatcagtct ttcttcattt atattctaaa 964681 aaggaaatca aaatccttta ttatgcttta tccaaaatta gtatataatg ggtcagggaa 964741 ggaggagatt cagtgcttac aattgatcac gtaacgaaga catttggaga ttataaagcc 964801 gttgacggat tggacttaga tattccggaa cagcaaatgt tcggtctatt aggcgcaaac 964861 ggagcgggaa aaacaacaac gtttcgcatg atcctaggat tattaagcat tacggagggc 964921 tcaatcagct ggaagggccg tcctgtgaat tatcatatca gcaacaaaat cggttatttg 964981 ccggaagagc ggggccttta tccgaaaatg aaggtaaggg atcagctcgt ctatcttgcc 965041 agattaaaag ggatggagaa gcgagaggct gtaaaagagc tcgggacatg gcttgaacgc 965101 ttcaatatta cagattacga gaataagaag gtggaagagc tttcgaaggg gaatcagcag 965161 aaaatccaat tcatttcggc agttttgcat aagccggagc tcctgattct tgatgaacca 965221 ttcagcggct tggaccctgt caatgttgag ctgctaaaag aggccgtgat ctcgctgaaa 965281 aacagcggtg tttctatttt attttcaagc catcggatgg aacatgtgga ggagctttgt 965341 gagaaccttt gcatattgca gaaaggaaaa ccggttgtac aaggcaagct gaaggagatc 965401 aagcgttctt tcggtaaaaa gaatgttacc attcactccg atgacgatct gcgctttttg 965461 cagtcccatg aaggcattct tcaatggaag gaaacggcag acggcgtcaa gctgcagatt 965521 gccaatgaag acatttctca agagattttt gcgatgctcc aaggaaaagg gtttatcaga 965581 aagtttgagc ttgaagagcc gtcactgcat gatattttta tagaaaaggt gggggccgtc 965641 tatgaataaa ttttggatca tgctttctca tacatacaaa aataagatta tggcaaaatc 965701 ctttattatt tcgactgtca tcacggtgct gcttgtttta gttgtaacga atctggagtc 965761 gatcatttct ttgtttcaag gtgacgatgc gaaagaaaaa atcgccgttg ttgatgaaac 965821 aaacgaatta tatccggttt tttctaagca gctgaaagcg gtggatacag acggcgatct 965881 tgatgtgaag ctgtcgaagc aatcggagga tgaggtcaca aagcaagtca aagatgaatc 965941 actcgatggc atgctcatca tcaaacgaga tgaaaaaggg accatttcag gaacatataa 966001 agcgttaacg atttctgatg aaagcacgta tcaaacactg cagcaggcgc tgacgcaaac 966061 caaaacagct gtcggaacag cggagctcgg cgtgtcgcag gaaacgatta gcagccttta 966121 tgcgcctgtt actgtggggc agaaggcgct gaaagaaggg gcaaagtctg aggaagagct 966181 tggccagacg gtagggcttg tttacattat gctgttcgtc atttatttct cggtgattat 966241 gtatgccagc atgatagcga tggaggtcgc aaccgaaaaa tcttcgcgag ttatggaaat 966301 cctgatctca agtatgccgc cgatccagca aatgtttgca aagctgcttg gtatcgggct 966361 tgtcgggatc acacagcttg ctattattat aggagccggc tctctgtcgc ttaagctgaa 966421 ccaaaagagc gaaacggctt catctgtcgg cggattcctt aatttgaccg acgtatctgc 966481 aaccactgtc atctatgctg tcattttctt tttgctcgga tactttttgt acgcgacact 966541 tgccgcgttt ctcggcagtg tcgtcagcag aatagaggac gtgcagcaaa cgatcacgcc 966601 gatgacgctt ttggttgtcg ccggttttat gatcgcgatg ttcggtttga atgcgcctga 966661 cgcaggattt attacggtaa cttcgtttat tccgttcttt acgccaatga ttatgttcct 966721 gcgcgtcggc atgcttgata ttccgttctg gcaggcggct gtcggaatcg gaatcacact 966781 gctcaccatt gtcatactgg ccgttatcgg cgccagaatt tataaaggcg gtgtattaat 966841 ttacggcaat tcaagcgcgt tcaaagcgat caaacaagcg ctacgtttag cgaaaaactg 966901 attggaaaac agcctgggga ttctcaggct gtttctttat tgacagaacg tgcattcgca 966961 agaattcggt gctaaaataa gggtacttca tcctggaaag gagcagaatg ttgactgatc 967021 taacctttat tcatgcggca gatcttcatc ttgacagccc gttttacggg atatcgcatc 967081 tgccggagcc gatttttgcc cggattaaag aaagcacgtt tgcaagcgtg agacatatga 967141 tagacgccgc agtgagagag cacgttgatt tcattttgct tgcgggagat ctgtttgatg 967201 aagccaatcg aagcttaaag gctcagctct ttttgaaaaa acagtttgaa agactcagag 967261 agtgcggaat ttcggtatac gtcatctttg ggaatcacga tcatcttggc ggggagtgga 967321 cgccgattga atggcctgag aatgtccata ttttttcgtc cgctgttcca gaagaaaaat 967381 cgttttttaa agaaggcagg cgcatagcaa gcatttacgg cttcagctat caagccagag 967441 cattgatgga aaaccaagcc gcccgctatc ggagatcaac tgacgcaccg tttcatatcg 967501 gcatgctcca cggcacgctg tcaggatctg aaggacacga tccgtattgc ccgtttacac 967561 atgacgacct cgtgaaaagc gggatggatt attgggcgct tggccatata cataaacgcc 967621 aggttctatc tgccgagcat ccggcagtca tttacccggg aaacacgcaa gcacgccata 967681 taaaggagac gggagataaa ggctattatc tcgttcatgt gacaaacgga gatatatctt 967741 atgaatttca gagagcgcat gatgtcctgt gggaaaaagc ggcggttgat gtgacggagg 967801 caaagaatat gacagccctc ttccaaatgg tggaggacac gttttcgaag ctgcggaaaa 967861 aggggagccc tgtttgtgta aggcttgttt tacaagggac ggcgccggaa tggctgctgg 967921 aggcgccaaa aggcaccttg gatgagtttc ttgaagctct tcaggaacaa gaagcggaag 967981 aggaacgttt cgtttggcct cttagattgg acgatgagac agaaaacgaa gcaaacctaa 968041 caaaccttga tccttttttt ggcggtttat ttgaagacat tgatcgcagc gatctgtcag 968101 acgtgctgga agggcttgag cggcatccag tgtatagaag gcacgcggac cggtttagcc 968161 aagaggaggt aaaggaaata aaagagcagg cacagataat attgaaaaga cagcttaagg 968221 tgcttgatac atgaggcggt gacagctttg cgaattatat ctttacatat ctaccaatac 968281 ggaaaatttt ccaatcggac ctttgacttt tccgcctctc ctgtccaagt catctacgga 968341 ttaaatgagg caggaaaaac gacgatgatg tcattcattg aaagcatgct gttcggtttt 968401 ccgaaaacga aaaagtatga accgaaaaca ggcggtgtct acggcggtgt tcttgaagct 968461 gaacatcctg agtatggggt gctgaagatc gaacggacga aagggactgc cgaaaaacta 968521 agcgtgtaca cagaaaaggg cgaagtaaag cagggagatg ttttaaagca gctgttccag 968581 ggcacagaca ggtcgttgta caaagccata tattcgttcg acgtattcgg gctgcaggaa 968641 attcacgcct ttaatcggga caagataggg gaatttttgc tcttttccag cttgtttggt 968701 gctgaagccg tatcaaagct tgattcaagg ctgacgaagg aaagcgaaag gctctataaa 968761 ccaaatgggc gaaaccctca attgaatcag gagctggaaa cgcttaagca gctggcagtt 968821 aagctaaaac aggctgaagc agaggaagcg ggctatcatc agcttctcga ggaaaaacga 968881 acgcttgaag cccgccttgc agccgcggaa accgaattga aagagacggc gggacatatc 968941 cgaatgattg agggagcgat tgagcgaaag ccgctgctaa atgaaaaagc gacactcgaa 969001 caggtgattg cagaatttcc ggaacacgca ggacaatttc ctgctgacgg actgcatcag 969061 ctggaaaaat atgaatccca tcttcacccg aaatcagcac agcttgaggc gcttcgggtg 969121 aagatggcgg agttggacaa acagaggcaa aagcttatcc ccgataaaga actattggcg 969181 aaagaaacgc tgatacaaga gctttcggca gcgtttcata tgtaccaatc ctggggagaa 969241 cagctggcag ccattcaggc acagctgcgc cagacgtctg cgcagacagc ggcagggctg 969301 gaacagctca ataaaacgga tgaaaatgag ctcctgaata tgaacacctc atatgattat 969361 gaatggcagc ttcagcaagc ggtgcagcaa tatgtacagg caagagacag aaaacggcag 969421 cttgacgaga cgtttgaact tgcccggcaa gagctggaag acgcggaaaa ggccgttcgt 969481 gccgcttcgt ccgcgattct tgaaaacagc caaagaaaag ataaagaagc agctcttaga 969541 gcatatgatg aaacacaggg gcagcaccaa gagcaagcga agctcagaga acagctaacg 969601 ttttttgaaa gacagcaggc taaacagaaa aagactgtca ttgcagctgg tatgttgttc 969661 atcgttctct tttctctgct gcagcaatgg attcccgcca taagtttcgg cgctgcactt 969721 attgtgtatt ggcttgtttc aggaaagtcg tcttctcgaa acagccgaga gacaagacag 969781 cccatgacgg atatttcacc agcagaagct gaaatgctta gagaagcgtt atgggaggat 969841 gaccgcaata agcagcacct tctcacacag cgtgcagcgc tccagcaaaa agaggcggcg 969901 tatgaaaggg tcatccagca gtttgaacag tgggaagccg aaatggcgcc gtcctttaca 969961 caggttgagc gttttatgaa tgagctcgga tttaaggaag atccatcatt tttgcttgat 970021 gcatacagct taatgaagga tgttaaaaaa gaagtgaaga aaaagcatga gctgaccata 970081 gaagcaggca ggctgaaaaa gcaccggaga acattcgaag aacgcgtcag tatgcttctt 970141 cccgtgaatc agagtcagga tatctccatt tcggacgccc ttcacacatt gcggaaaaac 970201 attgaacgtg aaaaagaaat tgagaagcaa aaaaaggaaa ttgaaacaga tattcattat 970261 acaaaggaac agatgcttga acttgagcaa gaaatacagt atttccacgc acagattgaa 970321 cagttatttg ccgcggctgc tgcaaaagac agagatgcgt tttttgccat agccgccatc 970381 agcaggcaat tgaaggatac ggagaacaag cttcatcacg taaacgcaca gcttcaaggc 970441 gggtacccgg aggaacttga actggcggat tccaatacgc tttctgaatt gaaagataag 970501 caatttgttg agaatgaaag aaaagagcgg ctgactgagg agatcgagca gctccgcagc 970561 caaatcgcac tgctctcagt caaacaggaa caattagagg cttcgggaat ggtctcagac 970621 ctcaagcttc aaaccgaaat gcaaaaagaa cgtgtgaaag aaacggctaa aaaatgggcc 970681 tccatacaaa tggtcaaaca ggtgatcaga aacaaattgg agcggcataa aaaaatcgag 970741 cttccgcgcc ttctggagac ggcaggagaa tttttccgtc ctctgactga cggaaactac 970801 caaaccattt atttttccga aacggatgat tcgatcatgg ttatgcatcg cgatggcact 970861 gtctatcatg cggaagagct gtcacaaggg acgtgtgaac agctgtatac agcgatccgc 970921 tttgctttgg ccgttacgcg ccagggtgag tcaaagcttc cgttccagct tgacgacagt 970981 tttgttcatt ttgatcagga aaggctgaaa cgtgtattac atgttctgta tgatttatct 971041 gaaggcggta ggcagatttt gtattttaca tgccatgagc acgtaaaaga tgcatttcat 971101 agcagccaaa tcatccattt ggtgtcataa aagaggttct atagctgaaa atcggtatgt 971161 gatatactgg tattatgtaa gatacggagg gagctttaat agaatggcta aagggattat 971221 gctacatgag gttggcgaac aggtggacca gtatctattg attaaatcct cgacgaaagg 971281 gattgcaagc aatggaaaac cgtttctgac gctgatgctg caagaccagt caggcgatat 971341 tgaagcgaag ctgtgggatg ccaagcaaag tgatgaagtg acctatgcgc cgcagacgat 971401 tgtcaaggtc gtcggcgatg ttcaccatta tcgcggacgc acccagctga agctaagaaa 971461 tatcagaccg gtaagcgagc aagaaaacgt caatattgat gattttttag aaaccgcgcc 971521 gattccgaaa aatgaaatga tggataccat cactcaatat atatttgaaa tgaaaaatcc 971581 gaatatccag cgaatcacaa ggtttttggt taaaaaacac gaagctgagt ttatggatta 971641 tccggcggct acgaaaaacc accatgagtt tgtctcaggt ttggcgtatc atgttgtctc 971701 tatgctgaac ctggcgaaag caatagcaga tttatatcct tctcttgatc gtgatctgct 971761 ttacgccggt gttatcctgc atgatcttgg aaaagtgaag gagctgtccg gccctgtttc 971821 cacttcatat acggttgaag gcaatttgct cggccatatt tccatcatgg tgacagagct 971881 ttcaaaagcg gctgaggagc ttcaaatcga ttctgaagag gtgttaattc ttcagcattt 971941 gattttgagt caccacggca aagcagaatg gggcagcccg aaaccgccta tggtgaaaga 972001 agcggaaatt cttcactata tagacaatct ggatgcaaaa atgaatatga tggacagagc 972061 gcttgagcgc gtgaagccgg gcgagtatac tgaacgtgta tttgcactgg aaaaccgttc 972121 cttttataaa ccgacatttc ataaataact taaaaaggac tgatgctgac atattcagct 972181 cagtcctttt tgatgcgtct ttcccgcaca taactcgtct cattcccgca tatggttaag 972241 aataaagaat ctatgcaaag ggggaggagc ccgtgttatt ttttccgtgg tgggtgtatc 972301 tttgtattgt aggcatcatt ttcagcgcat ataaacttgt ggcggcagcc aaagaggaag 972361 aaaaagtaga ccaggctttt attgaaaaag aaggacagat ttatatggag aggatggaaa 972421 aggagcgaga acgccgcagt tctcagcagc atgaagaaga aaatcaaaac cattccatcg 972481 cataaaaaaa gctgtgcggc tcaatgagcc gcacagcttt ttttattatt tagaattgct 972541 tgaagatgaa gaagtgctgt tgcttgttga agatgtatta aatgtgtctt tcagatcttt 972601 atcttttact tcgatgtcag ccttcttcat gactttttga acagcttcct gaacagctgc 972661 gttgtcattt aatttttgtt caagcacttc agatttcagt tcttttttca tatcatcata 972721 tttgccgcgt tcttctgtct ttttaatgat atggtagccg tattgcgttt tgacaggatc 972781 actgacttca cctgttttta atttgaatgc agctttgctg aatgtttcgt ccatttggcc 972841 ttcttttgcg aaccagccaa gatccccgcc ttttgaagca gagctgtctg ttgagtattc 972901 tttcgcaagg tcttcaaact tctcgccttt tttcagcttt ttctctactt cttcagctgt 972961 ctttttatca gcaacaagga tgtggcttgc acggattttg ccttttaagc cttcccagta 973021 ctctttgata tcggcgtctg ttactttgat gttatcttta gccgcttttt gtgtcagcaa 973081 ttcatatttt acttgttctt tcaggtaatc tttgccatat tgcttttcga gggcagtata 973141 ttgatcgcca agctgcgttt tgtattcttt cagcttgttg tcaatttctt tatccgaaac 973201 tttatacttc ttgtccaata ctttttcttg cactagctgt gtcagtacgc ttgcgccagc 973261 tgttttcttc atgtttgtgt aaagctcgcc ttttgtgaca tcgcctgcgt ctgtttttgc 973321 gataacttct ttgtcgccgc tgctgcaagc actgagagcg aggatgcttg tagcagtgat 973381 agctgctatt gcgattttct tcattgtttt caaacactcc taatcattcc aaattaaatt 973441 acctatgcgt atcataacat attgtggctt tctgtaaaaa gattttaaat aaagggcatt 973501 cgtctagtca aacttttgct gatgacatac ttatatattg atcaagaaaa ggaggtatgt 973561 aacatgagcg gaggatactc taacggattc gcgttgctcg tagtactgtt cattttgctt 973621 atcatcgtag gtgcagctta catctactaa gcagcccgag gatcgcttgc aacataagcg 973681 atcctttatt ttcactagcg cctaatcgtt tcaaacatga attgcataac atgtaattgg 973741 taaataaagc ttattacagg aggtgctatt taagatgggt gaagtatttg caggcggatt 973801 cgctttattg gttgtgttat ttattttatt gattatcatc ggcgcttctt ggctgtacta 973861 atcaacataa aaaagcatag ctgcttaatc agcagctatg ctttctttcg tatttacact 973921 gtaaaggaga tctccacaaa cgaagagatc agtaaaatta atatagatac attaataaat 973981 cggaatacct tatcttgccg ctcttcagga atctctctga caaggcataa tgtattggtg 974041 agcctgttta tgaaatataa aataaacacg gcagccacga taaaatagaa taaaatgatg 974101 ggagattccc cctctctctg aactgtccca tattacatta ccaaatattt attaaaaaag 974161 atagaatgca aattgaaaaa tcgccaccag caccagggtt tgactacttt tcaacaagaa 974221 tatccaagcc gtcagcttcc tgatcaataa aagcggtttt cggtgctttt atcagcttga 974281 gagccagcag gaaatcaggc agacagtagc cggcgtgaat gcccgagatc atgcaaaaat 974341 aatgagcgtg attcggaaat gccagtgctg cgtaaaacaa taccggtgta atcagcaaga 974401 acgggctgac gagtgaaatc agcattgttg tttttggtat acgtttccat gtgcgcatgc 974461 gcaatatgta aaactttttt tctatttttc tttttttgca gatgattggc aggacatgga 974521 tgactttatg tacaaataaa ataacgacga gcaaaccgcc gaataaagat acatattcat 974581 cgcttaagct tgtgccaggc cgcagcagct caaaagctaa aaaggtagat ataaaaacca 974641 aaatcataaa acatacagca gttaatatta tgcgaacggc gccataatcc ttcatgagat 974701 ttatggtctt ccagcaattc atcaaagtca tccttccata catcttgaat agaatctcaa 974761 aataatttac tcctcccaag agaaaaaatc aatgcttttt taagaaaaaa tatcatccgg 974821 caggtatttt tttgaaacaa gcaaacaaac tgcgaaatat ggggttagaa ctttcttctc 974881 agtgaattat cagctaaaat aagattaaag atagaaagaa gtggtgtgga tggattcgat 974941 ggatcatcgc attgagcgat tagaatatta catacaatta ttagtgaaaa cagtagatat 975001 ggacaggtac cccttctatg cgcttctcat tgataaaggg ctgagcaagg aagaagggga 975061 agcggttatg aggatatgcg acgaattgtc ggaagagctg gcaacacaaa aagcgcaagg 975121 atttgtaacc tttgataagc tccttgcgct ttttgccgga cagctgaatg aaaaattaga 975181 tgttcatgaa acaatttttg ccctgtatga gcaggggctt tatcaagagc tgatggaagt 975241 ctttatcgac atcatgaagc attttgatta actgtttaca ggttcgagct cttcagccgg 975301 ttcatccgcc gcactgtcct ttgctttttt cttcaatttt ccgtttacgc tttcaaagtc 975361 attgtcaata ttggtgagtg acgtttcgaa aatttccata aaatcatcgc cgtagatatg 975421 gcgtatcata cacatcattt ctgccacttc aggaaatttt ccgaataaat gatataaagg 975481 ctgtgaccct ttaaaaacag cgttgcgtgt cggatcaaat tcctcaagca agctccagaa 975541 tacctcggta ccttcctcag tcaattggac atatgtgttc cgtttatcat tcagccgttt 975601 ggagaacctt aaatatcccc gttcttccag cttttttgaa aagttgaatg cggttgatac 975661 gtgcatgacc ccgaatttcg cgatttcaga aatggaagct ccattcaatt gatacgcaat 975721 ccataaaata tgatgctcat taatattcag gtcatacggt ttgagccatt gctgccaatc 975781 cttctcgatc gatttccaaa gagccttgct aagctgagcc attttctggg tgaaaaccag 975841 agcttctttc acatcatagg gcggttccac tcgattcatt acgtcacctg cttctctttt 975901 tctttttctc tattatgcca ataaaataaa gattaataaa gatgaaaatg taagaatttt 975961 ttaataaatt cacaaaccat tgcgacgaaa gggtttttcg gccaaaaaaa atacgggtcc 976021 aattttggcc cgcatttttt tcttttgaat aggatattag ttttgtaagg ttttctccag 976081 ctgtctgatt ttctcttcga tatcggcaat ttctttttgc agatcctgct ggtgaggctt 976141 gatctcttcc tgccattttt taattgatgt ttggagctcg ccgcccacgt ctttaataac 976201 atccgtgctt tcttttgccg ctttgatcag ctggtctttt aatgcaagcc cgtctgactt 976261 taagcgtttg attgtttctt caaaagaatc ataattggtt ttcatttttt cacgcagctg 976321 ctttcctgag gaaggtgcag taagaagaac cgctgctcct ccgatgatgc cgcctacgaa 976381 tagtcctgtt aatagagaac gtccgctcgc cattacaatc accccgtctt tttcttcaaa 976441 ataggattca ttcagcattt ttcatttttg ttgaaagcct gaacttctat acatagcttg 976501 ctttatttta gcatattttt taagtgaaaa ggagggagaa ggttgtctgt ctttttgatt 976561 gtattatcct gcatcaccct tgccttcgct tcaggcgctg tttactatat caaacttctc 976621 agccaggctg cttcttatcc gcccaagagg gttatccggc agaaagcgct tgtttgttca 976681 accggaaccg cctttacact atgtcttatc tttttcacaa aactcctcgc ttaaaacatg 976741 ctgacatgct gcgggcgctc tgttcaaaaa aacctctccc ggaagcggaa gaggttttgt 976801 gtgacaatta tttagcagct tccataaagc ttgaacgcct taaaatggtt tgcacaatcg 976861 gataaataat gatcattgag attgtattca gcacagcggc cggcagaaca acagccgcga 976921 acaatgcggc gaaaccgccc ggtaaaccga cgatcaataa agctgacgat agaaacacaa 976981 ttcctgataa gatggtcccg atcactgtca gcacagcggc tgcacctgtt ttccggctct 977041 ttctgaacaa gagaaacagg gagaagaaca gaaacgctga tacgggttta tcaatgatgt 977101 tagggatctg tccggctgga aacgcggttg taagcgcgga aatgattccg gtcacgatcc 977161 cgatgacgag tacattttgc acccgcggga acagcagaat gcccatgaac atcatgatca 977221 gcatcatatc tggtttcatg ccgcctaaaa agggcggaat aatggaatga agcgctgcgc 977281 cgattgcggc aaacagagcc ataatgacta actcttttgt tttcataact atgctctcct 977341 ctgctaagct ttttgccctc caataatatg ctcatcattt attgcgaagg ctttacagaa 977401 tgtgttatgc aaacagtata ccaaacggac ggtttgcata gccagacttt ttactcattt 977461 tcctgctgga atttcttcat gaacgcagct aatttttcac agtcttcgag agagaccgcg 977521 ttataaatag aagcgcggca gcctcccacc gaacggtgtc cgccaaggcc gatcatcttc 977581 gcatcttttg ctttctgaac gaatgttttc gttaattcgt catcccgaag cgtgaatgtg 977641 acattcatgc gtgagcggct gtcttttctg gcatgtcctt tatagaagcc gttgctttca 977701 tcaatacagc tgtagagaac ctgcgctttt tgttcattgc gctgttcaac agcttccaca 977761 ccgccgtttt ccttgagcca ttccagaacg aggctcagca tataaatcgc aaatgtcggc 977821 ggagtgttgt agagtgaatc cgctttgaca tgcgtggaat atttcaagat ttttgggacg 977881 ttcgcatttt cattttgcag ccagcttttt ttcatgatga ctacagtcac gccggaaggg 977941 ccgaggttct tttgggcgcc tccgtagatc acatcaaatt tggacacatc gatttttctg 978001 cttaaaatat cgctggacat gtcggctacg agcggaattg gagaattcgg aaactcctgc 978061 cactgagtgc cgaaaattgt attgttggat gtgatatgta aatatgcgcc gtcttttaca 978121 tccgtaaggt caacctctgg aatataactg taattgtctg tttcacttgt agcggtgata 978181 gacgtgttcc cgaacagttt cgtttctgcc agtgcttttt cagaccaagc gccggtcatc 978241 acaaaatgtg cggttttttc aggtgttaaa aagttcatcg gaagcattga gaattgaagg 978301 cttgccccgc cttgaagaaa caagatatcg taatcttccg gaatgcccat cagttcgatt 978361 aagaggcttt tcgctttttg gtgcaccgct tcatactctt tgctgcggtg ggaaagctcc 978421 ataacagaca tgccggattc gttaaaatca ataaattctt tctgtgcttt ttgcagaact 978481 tccagtggca gcgctgcagg acctgcgtta aaattcgttg tacgttccat tatgatctct 978541 ccctgttttc cacgttaatg tataaaataa tacaattatc ctatcacaaa aattcagttt 978601 tttgataaaa aattagaatt atcaaaagaa attgacggat gtttgcgaaa tgttcacaaa 978661 ataaaataac ctcatcttat gatgaggcca ggcgttttgc gatagaggaa gagatgttct 978721 gcagatcctc cggtttataa tcatcagcat gcgttttcca aaccgctccg aatccatctc 978781 cttttccgta gcgagggata atatgcatat ggtagtggaa cacagattgt ccagcttttt 978841 cgccgttatt gttcagcgta tttaagccga tcggttcaaa ttcatcccgg atagcgcggg 978901 cgatttttgg aacagcatgg aaatattgtt ttgctaattc atctgtaaat tcatatacat 978961 tctcaatatg tgttttcgga atgacaagcg tatggccttt tgtcacttgg ctgatatcaa 979021 gaaaggcaag tacatgttca tcttcataca ccttcgctga tggaatgtcg ccggcaataa 979081 ttttacaaaa gatacaattc tctgcacaat gcatgagggt tcctccttat gaaattgttt 979141 agtatgtata cattcatcgt accacagaaa tgcagaaaat agaaaacagg atgaacggcg 979201 agcgttcacc ctgaatgcag aggaagagct tatatgaaga aaatgtgtta tgcctttggt 979261 aagcacctca tttgtcaata aaatgaagac ttgtttaatg cctaacgatt cctgcgataa 979321 acacctcatt tgacaatttg cttcatacat gaagaattca tcaattcagt gaagagaaat 979381 ggtttgagca ttggacatgt ttattttcta tccaactgtt tctaagacgt ctttgacaaa 979441 cacctcattt ttcagttgat atgcttttcc tctacaactt ttatgatgtc cagaaccctg 979501 tctctttatg acagcaaatt catcatttgt taaaagggaa ttgtttcaaa tcaggccttg 979561 tttttggtac tatgaagaaa aacactataa ggggagaaac tatgtctctg ctatcggtaa 979621 aagacttgac cggcggatat acaaggaatc cggttttaaa aaacgtatca ttcacccttg 979681 aaccgaatca aattgtcggc ttaatcgggc tgaatggtgc tggtaaaagt acaacaatca 979741 gacacatcat cgggctgatg gacccgcata aaggttcaat cgaattaaac ggtaaaacgt 979801 ttgctgagga tccggaaggc taccgttcac aatttaccta tatacctgaa acacctgttt 979861 tatacgaaga attgacgctg atggagcatc ttgaactaac agccatggca tatggactgt 979921 caaaagaaac gatggagaaa aggctgcctc cgctactaaa ggaattccga atggaaaaga 979981 ggctgaagtg gttcccggcc catttttcta aaggaatgaa gcagaaggtt atgattatgt 980041 gcgcattttt ggcagagcct gcgctctaca ttattgatga gccttttcta gggcttgatc 980101 cgcttgccat taacgcgctg cttgaacgga tgaatgaagc gaaaaaaggc ggggcgagcg 980161 tgctgatgtc aacacacatt ttggcaacgg cagaacgcta ttgcgattcg tttattattt 980221 tacataacgg cgaggtgcgg gcgcgcggca cgctgtcaga gctcagagag cagtttggaa 980281 tgaaggacgc ggcgctggac gatttgtatc ttgagcttac aaaggaagac gctggccatg 980341 aataatatgc ttgatatttg gcagtcgcgg ctgcaggagc atatcaaaga aacaagaaca 980401 tacatgaaat atatgctcaa cgatcacctc gtcattgttt tgattttttt tctagcgggc 980461 gctgcaagct ggtacagcaa atggatacgg gacattcccg ctcactttcc gtccttttgg 980521 gtgatggccg tgctgttttc gctcgtattg acaagctctt atgtgcgaac gcttttgaag 980581 gaggctgacc ttgttttctt attgcctctt gaagcaaaaa tggagcctta cttgaagcag 980641 gcgtttgtct acagctatgt gtctcagctg tttccgctga ttgcgctgag catcgttgcg 980701 atgccgcttt atttcgcagt cactccggga gcttcgctcg tatcgtatgc cgcggtcttt 980761 gtccaactgt tgctgctgaa agcgtggaat caggtaatgg aatggcgaac gactttccaa 980821 aacgaccgca gcatgaaacg gatggacgtc atcattcgct ttgcggcgaa tacactcgtt 980881 ctttattttg ttttccaatc tgtttatatg tatgcgcttc tcgtctatgt cattatggct 980941 gttctttatc tgtatatgtc ttccgcagca aaacggaaaa catttaaatg ggagagccat 981001 attgagtccg aattgagacg aaagcagcgt ttctatcgga ttgccaacct gtttactgat 981061 gtgccgcatt tgcgaaagca agccaaacgc agagcttatc tcgacttttt gctgcggctt 981121 gtgccgtttg aacagcgcaa aacatttgcc tatatgttca cccgcgcctt tttgcgttcg 981181 agcgattatt tgggcattct tgtcagatta acgatcgttt tcgcgctgat cattatgtat 981241 gtctcagcca gcccgctgat tgccgcggtt ttgactgtgt ttgccatttt cattacgggc 981301 attcagcttc tgccgctctt cggtcacttt gaccatctgg cgcttcaaga gctgtaccct 981361 gtgcaaaaag aaacaaagct gaaaagctat ttctctctat taaaaactgc acttagtatt 981421 caagcgctgc tgatgtctgt tgcatctgcc tatgcagccg gcttgaccgg ttttctgtac 981481 gcgctgatcg gttctgccgt tctgattttt gttgttttgc ctgcttatat gacgaccagg 981541 ctgaaaaagc acggaaagct gtgaactgaa aagaggtaat caaatgacag ataatcagct 981601 gctgatgcag gaagctttgg aatggaaaat gcattttttg cgaaaggatt ccatgtttga 981661 acgcttttcg aagcgtgtcc agacgaaggt gaatgaacgg attcctgaaa aaatccatac 981721 ggtcgtcacc gagagtgtga aaaaaatggt agaagcgaca atggccggct ctaatatcat 981781 cacctataaa aaggatacaa gtgcactgtc gctcagtgaa aaaaacgaat tggcgaaaaa 981841 aacgattgtt tcttatcaaa aagtggcagc tgctgaggga gtcggcaccg gagcgggcgg 981901 cattttttta agcattgctg attttccgct gctgctttca attaagatga agtgtttatt 981961 taccttgtct tccatttacg gctttgatgt caaggatgca caagaaagga tatttttgct 982021 gctcgtgttt cagcttgcgt tttcgagtga tgatggccgt aagtcgcttt tttctgtcat 982081 cgaaaattgg gagacggaga aaaagagcat cgactggaga gtgttccagc aggaatatcg 982141 cgattatatc gacgtcgtga agctttttca gcttttgccg ggcgtaggag cggcagtcgg 982201 cggaattgcc aattataagc tgcttgctca gcttggagaa acggcaagac atgtttttca 982261 tctgaggata ttaaaggaaa cagccggaga ataaacactc cggctgtttt tttatagctg 982321 atgataggtg atcgcagcgc cggcaaggac cttggccgct gtcagcatgg ctttttcgtt 982381 gatatcaaat ttcggatggt ggtgggaata gactcgctct ggctgttcgg gagcggcgcc 982441 tgtaaagaaa aaagtgccct tcacgttttg taagtaataa gcaaaatcct cgccgcccat 982501 ttgtggttca ccgtcaatga cctgctgaac gccctcggta ttctttgcgg tgctcaccaa 982561 gtggttcgtt tctgcaggat ggttcacaac cgctggataa ccctgttcat aggtgtactc 982621 ataggacgcg ccgtgcatgc tgcatattcc ttttacaacc gcttcaattt ctttctccag 982681 aatgtcccgg acattttcat caaaagaacg cgctgtgccg atgagtactg cttggtctgc 982741 gatgacatta aacggattgt cggcgatgaa ggagcctgtc gaaatgacgg cggattgaat 982801 cggattgact ttgcggctga caatgtgctg caaagaggaa acgatttgcg aaccgattag 982861 gacggcgtct ttagtatcat gcggatgagc gccgtggccg ccctttccga agactttaat 982921 cgtaaatcgg tctgccgccg ccattacggc gccggggcgg cagagaatag ttccgagcgg 982981 ctcagttgcc caaagatgag tgccgaatat cacatccgtg ttttcgagac atccgtcatc 983041 aatcattggc tttgcgcctc caggataata ttcttctgca tgctggtgga tcatcacaaa 983101 tgttcccttc agttcatgtc tgttttggtg aaggaccttg gccactgcga gaagagctgc 983161 ggtgtggccg tcgtggccgc atgcatgcat gacaccaggc actttggagg cgtaagggac 983221 atctttttca tcttgaatgg ggagagcgtc aaagtcggcc ctcaaagcga ctgtagggcc 983281 gggttcgctt ccttctatat ttgctaaaac ccctctaccg ccaacgtttg tgcggattgg 983341 gactcctaac gattcataat aggaagcaat aaatgcggcg gttttttctt cttgaaatga 983401 gagctcagga tacatatgaa aatggcgcct gatctcaacc atttcttcaa aacagccgtc 983461 gagctgtttg tttatctctt tctgcagtgt ggatatggac aaagccgctt cccccttttc 983521 tatgcttttc catgattgta tagaaaaagt ctgaatattt caactcatgc tgttttaaag 983581 catcatcaca gctgcgaggg ttgtcaccaa aaggccaatc gcgacgggaa tgaagttttt 983641 tctggcaagc tcaaaaggat caactttgca aatggccgcg gcgggaatca aagcccatgg 983701 gaccagtgtt cctccgccca cccagatggc agagatttgt ccgagcgcgg tcagaatagc 983761 gggatcggca tggagagcgg acgaaaagag ctttgcgatg gagccggcga gagaaatgcc 983821 agaaaatcct gagccgtcaa ggcctgttat ggctccagcg gcagttaatg cagtggcggc 983881 aagctccttt gacataggca tcatatggga taaagcaatg ccaagatcgt tgacaatgcc 983941 gtgggaacct ttagggagtg aagtgcccag tatgctttca tagcctgagt cgccaagata 984001 aaagaaagcg gcaatcggga tgacggggcc gaaaacctta aaaccgaact taaatccgtc 984061 aataaaatag ccggtgattt tttcaagccc tttatgctta tacacgaaaa aatgaacggt 984121 aaagaggata caaattgcag acccgccaat taacgcggtt gcatcatttc cttgtaggtt 984181 aaacaagagc atgcaggcga tatctgcaag aaaggcaagc ggaatcaaaa aagccagtat 984241 ggaccgcagg cgttttggca agtacagcga gttgtcttgt tcgccggaaa gaacggggga 984301 aaaagaagtg ggatgctcct gttttttgcg ttcgcgctga atcatgataa aggcagcagt 984361 tgttgttgtc acacccataa tcagcacaag cggaatactg gccgagacga catcaccgac 984421 tggaatgcct gctgcatccg cagtcagctt tggcgccgcc tgaatgacaa agtctcctga 984481 cagggcaaaa ccgtgtccga ataagttcat ggccatggcc gcggcaagag gcgtcaaacc 984541 ggcacgtgcg gctgcgggga gcaggacggc gccgatcaaa gcgacacccg gagaaggcca 984601 gaagaataga gaaatggcga acatcaggcc tccaatcagc caataggcag tcacaggccc 984661 tctcacaagg cttgcaaagg gagaaatcat cgcttcattt atccctgttt ttgttaacaa 984721 atcactcatt gaaacgataa agcaaatgat gaaaatcgtg ggcagcagtt cgccggccgc 984781 atagataaag ctgtggaata aactgctgac agaagctgaa agtgaatggc tggcccatag 984841 cgatatgata aaaatgccga atagagaaat aaatgtcgtg tcttttctca gcagcataaa 984901 taggataatt gcaccgataa aaaacacata cagaacatgg acaggcaaaa tcccgacttc 984961 catcatcgat cactccttcc gcttacagat tattcatagg cgggcggaag gtgccgggac 985021 agaggggagg gttatgatgg aagatgaaca ttgatctgtt tcagctgctc aatcagatga 985081 tgccttaatc ctctattcgc tttttgcaga tgttttggga agcattcagg agaaaaaatg 985141 acgcaccctt cagcaagcca gttttttcta taggcgatga tgctttccga tggctctata 985201 tgagttatcc tcgtgctgca tctcgtactc atcaaatccg aactgaaaac cgcagcacgg 985261 gcagatttca tgagaatgat tgccttcatg atcatatggc ggttcagcca atccttaaac 985321 ccgcagactg ggcaagtatg cttcattttg ctttcctccc aataaaataa gctgccggac 985381 atgccggcag ctattcgaca gcgaaatatg tggtgacata ggaaggccgg gagaagatcg 985441 acgttgtgtc aattccggca gatgtatcgc gttttttgtg ggcttctttg taagaaccgg 985501 actgctgcca gtcttgaaag gcgctttccg tttcccacaa ggtcagaatg acataggtgt 985561 cactgtcaag cggacggagc actcgaattg cttcaaagcc aggctcgttt tcgacttttc 985621 ccgctctgtt tttaaatctg ttttcaaaca gcggacgccc ttcctgagta acggcaatat 985681 tgttcaatac tgcaaaaccg ggatgtttga tctctccgac ttggtcaatg acttcataag 985741 cgtgtggtgc ctggaaaacg gtatctccgt ttgtttcatg aattaaaatg gcgttttcct 985801 gcccctgcat caaaaggata ttttctgagg gatgcttctg tacgatcgtt tttaaaaaat 985861 cggctgtccc atatgtaata taaaccttca tatcagccac ctcctgcttg ctagtatatc 985921 aaaacaatgg tataagtttc tattggcgag tgcttcgaac ataattccaa acaatttttc 985981 ccatactacc tttagaaagg cgaggtgagt tcatgtttaa gataaagaaa aagaaacttt 986041 ttatacctat cattatttta gtgttaactg cttttctcgc tttaatagga tatatttcaa 986101 ttatttttct cggccattat gtcatagatg aaaaaaagct tattcttcat gcttcttcaa 986161 aaattgttga tcaaaacgga gatgaggttg caagcctgta tacagaaaat cgcgagccgg 986221 tctcgatcaa tgagattcct aagcaggtca gagaagcgtt tatcgctgtt gaggataaaa 986281 ggttctatga gcatcacggc attgatgcaa aatccgtcgg aagggcagtg taccgcgata 986341 tattagcagg cggaaaggtg gaaggcggaa gcacgatcac ccagcagctt gccaaaaata 986401 tttttctgac acatgacaaa acatttctaa gaaaaacaaa agaagtgatc attgcgatta 986461 atcttgaacg ggattacagc aaggacaagc tgcttgaaat gtatttaaac cagctttact 986521 tcggacacgg ggtttacggc atacaagcgg cgtcccacta ttattttaat aaagaagtaa 986581 aagatttgac tgtatctgaa ggcgctgttt tggccgctat tccgaaggcg ccttctacgt 986641 actctccaat tttgcaccct gataaaaata aggagcggcg tgatacaatt ctaggtatga 986701 tgaatgacca aggctatatc agtgcgaaag aggctgtcac cgcacagggc cggacgcttg 986761 gactgcatgt gaagaaacag tcggaaacac cttggtttga cagctacatt gaccttgtga 986821 tcaaagaggc ggaagacaag tattccattt ccggagagca gcttcttcaa ggcggataca 986881 cgatcaaggt gccgctcgat tcgaagctgc agaagacggc ttaccaggtg atgaaagagg 986941 gaagctatta tcccggaaca gatcagaatg ccgagggaag cgcggtcttt attaataaca 987001 agacaggcgg tgtagaagcg gccatcggcg gaagggatta cacatccaaa ggatataacc 987061 gtgtcacagc tgtccgccag ccgggttcca catttaagcc gcttgctgta tacggaccgg 987121 cgatgcagga aaagaaattt aagccatatt ctctattgaa ggatgagttg cagtcctacg 987181 gagattatac gccgaaaaac tacgacagcc ggtatgaggg cgaagtcact atgtctgacg 987241 ccattacgta cagcaaaaac gcgccggctg tctggacgct gaatgagatc ggcgtcgaaa 987301 cagggaaatc ttatttgaaa gcaaacggca ttgatatccc tgatgaaggc cttgctcttg 987361 ctctaggcgg cttggaaaaa ggcgtttcac cgctccagct tgccggcgcg tttcatacat 987421 ttgccgcgaa tggaacgtat actgaaccct tctttatctc gagcataata gatgaagacg 987481 gagaaacaat agccgatcat aaagaagaag gaaagcgggt attcagcaag cagacgtctt 987541 ggaatatgac gagaatgctg cagcaggtag tcaaaaaggg aacggccacg tccggcacct 987601 atcacggcga cctggcggga aaaacaggtt caacatctta tacaggcgtc tccggcgcga 987661 caaaggacgc ctggtttgca ggctatacgc cgaaaataac cggggcagtc tggatgggct 987721 atgacaaaac ggatcaaaac cattatttga aagccgggag ctcatacccg acgcggctgt 987781 ttaaggatat tttgacacag gcaggagaaa ccggtcatgt gttcacaaag cctaaaaacg 987841 ttaaagaact ggaaagcccg attgagctga agccggtcaa aacactcaca gccgattaca 987901 catttaaagc agcggggctc tttactattg aattaaagtg ggacgctcaa gaggatgatc 987961 gggccgtata cagaatttat gtaaacaagg acggcgagga gacgcttctt gattcggttg 988021 aagggaaggg aagctatgaa attccttatg ccaacttatt ttcgggcgcg tcttataaaa 988081 ttgtgcctta taatacacag acaaaaagag aaggggaagg aaccgattac gttcagccaa 988141 aattgttttc ctcttaatgg aattcggcga ttttttgaac tttgagctac atttctatac 988201 catttgccta aaacaaggta tagtgtaata agtcaagaaa tacgaacgta tggttgccgt 988261 atgaaaggtg gaaatcagat gagtaaacga gaaacgttta acgagacgtt tttaaaagct 988321 gcgcggggag aaaaagcgga tcacacgcct gtgtggtata tgaggcaagc agggcgctca 988381 cagccggaat accgcaagct gaaggaaaag tacggattgt ttgagatcac acatcagccc 988441 gaactttgtg cgtatgtcac aagactgccg gttgagcaat acggagtcga tgctgcaatc 988501 ctttataaag atatcatgac gccgctgccg tcaatcggtg tggatgttga aatcaaaaac 988561 gggatcggtc ctgtgattga tcagccaatc cggtctctgg cggacattga aaaactcggc 988621 cagattgatc cggaacagga cgtgccgtac gtgcttgaga cgattaaact gcttgtcaat 988681 gagcagctga acgtcccgct catcggtttc tcaggtgcgc cttttacgct tgcaagctat 988741 atgatcgaag gcggcccgtc gaaaaactac aataaaacaa aagccttcat gtacagcatg 988801 ccagatgcat ggaatctgct gatgtccaag cttgccgaca tgatcatcgt gtacgtgaaa 988861 gcgcagattg aggcaggcgc aaaagcgatt caaatctttg attcgtgggt cggcgcattg 988921 aatcaggcag attacagaac atacatcaaa cccgtgatga accggatctt ttcagagctc 988981 gcaaaggaga atgtgccgct gatcatgttt ggcgttggcg caagccatct tgcaggtgat 989041 tggcatgacc ttcctctcga tgttgtcggg cttgactgga gactcggcat tgatgaagcc 989101 agatcaaaag gaattactaa aacagtgcag ggcaacctgg acccgtccat tttgcttgcg 989161 ccatgggaag tcattgagca gaaaacgaag gaaatacttg atcagggtat ggagtcagac 989221 ggcttcattt tcaatcttgg ccatggggta tttcctgatg tcagtcccga ggttttgaaa 989281 aaactgacag catttgtcca tgaatattca caaaacaaaa aaatgggtca atattcctaa 989341 gcatatcttt tggtatctta atgatatcct gtcaaaatgt ttgtatcaga tcattaaaga 989401 gggtgtaaac agtgagtaga aagaaaatgg ggcttctcgt gatggcgtac ggcacgcctt 989461 ataaggaaga agatattgaa cgttattata cacatatcag aagaggcaga aagcctgaac 989521 ctgaaatgct tcaagatttg aaagacagat acgaagcgat tggcggcatt tcaccgcttg 989581 cccaaatcac agaacagcag gcgcataatc tggaacagca cttgaatgaa attcaggatg 989641 agattacgtt taaagcgtat atcggactga agcatatcga gccgtttatt gaagacgccg 989701 tagcagagat gcataaggat ggcattacag aagcagtcag catcgtgctg gcgccgcatt 989761 tctccacgtt cagcgttcag tcctacaaca aacgcgccaa agaagaggct gaaaaactcg 989821 gcggcttaac gattacgtca gttgaaagct ggtacgatga accgaagttc gtgacatatt 989881 gggttgaccg agtgaaggaa acatatgcgt caatgcctga ggatgaaaga gaaaacgcaa 989941 tgctcatcgt atccgcacac agcctgccgg aaaaaatcaa agaatttgga gacccgtacc 990001 cggaccagct tcatgaatcg gcgaaattaa ttgctgaagg cgcaggcgtt tccgaatatg 990061 ctgtcggctg gcaaagtgaa gggaacacgc ctgatccttg gctcggaccc gatgttcagg 990121 atttaacacg tgatttattc gaacaaaaag gctatcaagc atttgtatat gttcctgttg 990181 ggtttgtcgc ggatcactta gaagtgcttt atgataatga ttatgaatgc aaagtggtta 990241 ctgacgatat cggcgcaagc tattaccggc cggaaatgcc aaatgccaag cctgaattta 990301 ttgatgcttt ggcaacagtc gtattaaaaa aattaggacg ttaaagaagg cgatgaacat 990361 gagtgacggc aaaaaacatg tagtcatcat cggcggcggc attaccggtt tagccgccgc 990421 cttctatatg gaaaaagaaa tcaaagaaaa gaatctgccg cttgagctga cacttgttga 990481 ggcaagtccg agagtcggcg ggaaaatcca gactgtcaag aaagacggct atatcatcga 990541 aagagggcca gactcatttc tggaacgaaa gaaaagcgcc ccgcagcttg ttaaagactt 990601 aggtcttgag catttgcttg tcaacaatgc gaccgggcaa tcctatgtgc ttgtaaaccg 990661 caccctgcat ccaatgccga agggcgctgt aatggggata ccgacaaaaa ttgcgccgtt 990721 tgtttctacg ggtctgtttt ccttgtccgg gaaggcgaga gctgctatgg atttcatcct 990781 gcctgcaagc aaaacaaagg atgatcagtc attgggagaa ttcttccgca gacgtgtcgg 990841 agatgaagtg gtcgagaact taatcgagcc gctactatca gggatctacg caggcgacat 990901 tgacaagctc agcctgatgt cgacatttcc gcaattttat cagacggaac aaaagcatag 990961 aagcctgatt ctcggcatga aaaaaacaag gcctcaaggc tcaggccagc agctgacggc 991021 aaaaaaacaa gggcagttcc aaactctgtc aaccggtttg cagacccttg tagaagagat 991081 cgaaaagcag ttaaagctga cgaaggtgta taaaggcaca aaagtgacca aacttagcca 991141 tagcggctct tgctattcgc tcgaactgga taacggcgtc acacttgatg ctgattcagt 991201 aattgtgact gctccgcata aagcggctgc gggaatgctt tctgagcttc ctgccatttc 991261 tcatttgaaa aatatgcact ccacatccgt ggcaaacgtc gctttaggtt tccctgaagg 991321 ctccgtccaa atggagcatg agggcacggg ttttgtcatt tcaagaaaca gtgactttgc 991381 gatcacagcc tgtacgtgga cgaataaaaa atggccgcac gcagcgccgg aaggcaaaac 991441 gctgcttcgg gcatatgtcg gaaaagccgg agacgaatcc attgtcgatc tatcagataa 991501 tgacattatc aacattgtgt tagaagactt aaagaaagtc atgaacataa acggcgagcc 991561 ggaaatgaca tgtgtaaccc gatggcatga aagcatgccg cagtaccatg tcggccataa 991621 gcagcgtatc aaggagctgc gtgaagcact tgcatctgcg tatccgggtg tttatatgac 991681 aggcgcttct ttcgaaggtg tcggcattcc cgactgcatt gatcaaggaa aagctgccgt 991741 gtctgacgcg cttacctatt tattcagcta aaacctccgc tttatcgcgg aggttttttt 991801 gatgtgcaat ggcaatattg tgtaaaaaat gattgaattg aacagcaggt tatgatacat 991861 ttgcatatgt acttaatgac taaaatgttc aaacggtcag tttcgaggtg aatacaatgt 991921 caatagatcg aaaaaagctc attttggagg cggctacaaa gtctttcacg cagttcgggt 991981 ataaagcgac gacaatggat cttgtcgcaa aacttgcgaa cgtggggaag ggaaccattt 992041 atactttttt caaaaacaaa gaagagctgt ttgacgagat tttcactact ttattaaagg 992101 aaatgaagca aaaagcggat gaagcgatgg agccgagcct tccgttccat gaaaatgtgc 992161 acagagcgct gtttgccatt ctggagttca ggaaaacaca tcagctgacg attaaaattt 992221 tccaagagaa tgccgagatt ggtacaatgg cagttcagga agtgatccag aaaatggagc 992281 gatccatcct gtcttatatc aaaagcaaga ttgaagacgg gatcaaaagc ggcgcaatca 992341 agccgtgcga ccctgagctg acagcctttg tgatgctgaa gctttatatc gcgctcattt 992401 ttgactggga aaaacaacac cccccgcttg ataaagagac aattgcggga ctgcttgaat 992461 tgtatgttgt caaaggattg tcagcgaact agataatcct ttctctttgc aagaaaatga 992521 ccatttttta tgatgagtca gttttagaat ggaggcatca ggatgaacac aatacgaagt 992581 cagtggaaag acatcgtaac aagtaaaaaa ttattgattc ccatcatcgc cattttgttt 992641 gtcccgctta tttacagcgg cgtattctta aaggcttatt gggacccgta cggcacagtt 992701 gaccagctgc ctgtcgttgt cgtcaaccaa gacaagggag caacgtatga aggagaaaaa 992761 cttcaaatcg gtgatgatct ggtcaaagaa ttaaaggata ataacaactt tgattggcat 992821 ttttccaatg atctcgacca atcgttaaag gacttattga atcaaaaata ttatttagtt 992881 gtcgagattc ctgaggattt ttctaagaat gccagcactg tattagacaa aaatccgaaa 992941 aaattggatc tgaaatacca tacaaatgca ggttctaact atgtaggggc aacgatcggc 993001 gaaaaagcga ttgataaact gaaagcctct gtttcaaaag aagtgaccga gcaatatacg 993061 aaagttattt ttgataactt taaagatatc gcaaaaggtt tgagcgacgc gagcagcggc 993121 gcgaaaaaaa ttgatgacgg cacaaaggat gcgaaaaacg gaagcgccca gctgaaagaa 993181 aatctggcga agctgaagga aagcaccgct accatcagtg acaaaacagc gcagcttgca 993241 gatggagcgg ctcaggtgac gagcggcatc caatcacttg acagctcgct cggtaaattc 993301 caggacagca gcaaccagat ttatgataaa tctagtcagc ttgcagcagg atcaggcgag 993361 ctgacaagca agatgaatga acttcttgcc ggacttcaaa atgtgcagaa gggtacgcct 993421 aatcttacta acgggttgga tcagctcaac agtaaagtcc aagaaggttc tgagaaagcg 993481 gcaaaagcgg aaaagatcat taatgcgctc gatttaacga agcttgaaac tgctgtaaac 993541 aatctggaaa agtcagaaac tgcgatgaag gaattcaaaa aacagctgac tgactttgaa 993601 aacagtttga aaaaccgtga tcaggcattt aaaaatgtca tcaattcgag tgacttctta 993661 acagcggagc aaaaaagcca gctgattaat tctgttgaga aaaagcttcc gcaagttgat 993721 gcgcctgatt ttgatcaaat attaagccag ctacctacag ctgatcagct gcctgacatc 993781 gcaacgataa aaagctctct tgaagacgtg aaagcgcagg tggcgcaggt gaaagccatg 993841 ccggaagcta catctaagct ttataacggc gcaaaaacaa tccaagatgc gattgacaga 993901 ttaactgagg gagctgataa gatatacaac ggttctcaga agctgacaga tggccaaact 993961 aaactgacag cgggcatcgg tgaatataat aagcagttcg caaaagcaaa agcgggctca 994021 gagcaattgg tgacaggaag cagccaagta tccggcggat tgtttaagct gttagacggg 994081 tctaaacagg tccaaagcgg atcatcaaaa cttgcagacg gatctgcatc acttgataca 994141 ggtttaggca agctattgga cggcacagga gagctgtcta gtaagctgaa ggatgcggct 994201 gaccaaacag gagatatcga tgctgatgat caaacatacg gcatgtttgc ggatccggtt 994261 aaaaccaaag atgatgccat tcattccgtt cctaactatg gaacagggct gacaccttat 994321 atcctgtcaa tgggcttgta tgtcggcggc atcatgctga cggttgtctt cccgctgaag 994381 gaagcgtcag gacgtccgag aaacggtttt gagtggttct tcagcaaatt caatgtcatg 994441 atgcttgtag gaatcattca atcattgatt gtggcgacgg ttcttctatt gggaattggt 994501 cttgaggtag agagcacgtg gagattttac gtgtttacga tcattacgag tctcgctttc 994561 ctggcgataa ttcaattttt ggctacaacg atgggcaacc cggggcgatt tatcgcagtc 994621 attattttag tgctgcagct gggagcgagc ggaggaacct tcccgctgga attgcttccg 994681 aatttctatc aggtcatcca cggcgcattg ccgatgacct acagcattaa cggattcaga 994741 gcagtcattt caaacggtga ctttggctac atgtggcaga tggccggcgt cttaatcggc 994801 attgccctcg tcatgattgc actaagcatt acttacttta caatgttaag ccggaaggaa 994861 gaaacatcag aagaacagcc ggcttcataa agaaaaagaa cttgtttcct tggaaacaag 994921 ttcttttttt gttacatccc ccatttaata agcaatcctg tataggttaa tccgccgcca 994981 aacccgaaaa gcaaaacgat ttgatctttt ttcagcttcc cggctttcac tgcgagatcg 995041 agcgccaaaa caattgaaac cgaagacgtg tttccgtagt gctcaacact agtgagcgtt 995101 ttttcaatcg ggaacggtgt tttttcacaa attgactcga tcatgcgcaa gttggcgctg 995161 tgaggaacaa accaatcgag atcatcggag ctgagtcctg ctttatgtaa aagccgttca 995221 aattcgccag ggacggttct tgcggcccat ttatatacct cgcgtccgtt ttgcaccatt 995281 tttccggaac cgacaagctg cacaccgttt atttcatttc gcagtccggc acgatacaaa 995341 atatcgccgc cgttcccgct tgttccttgt acagacgcaa gaaatcccgg cgtctcttca 995401 tctcgttcta ctaacagcgc acccgcggca tcgccgaaca gtacgcatgt cgttcgatcg 995461 gtataatcgg ttacctttga taacgtctct ccggcgatga cgagaatttt ttgatgaagg 995521 ccagatgtga tcaatccatt tgccaaatgg aggccgtatg tcagcccggc gcatgtcgca 995581 ttaatatcca gcgcgccggt gctttcccag ccgaaatatt cctgtacgcg gcatgccgta 995641 ctcggaaagg cgtaatcgga tgtggttgtg gcaacgagga tcatatcgac atcatcaagc 995701 gttcctttat aacggctctt gagattcttc accgcttcta tgcataaatc agaggtaaat 995761 tgatgttcat ccgcaatccg gcgttctctc attcctgtgc gctgaacgat ccattcatca 995821 gaggtatcaa cgatcttttc taaatctgca ttggttaaac gtctgctcgg cgcataggtg 995881 ccgatagctg taatttttgc ttttgacata tgaatcactc cttatggtca gattataaca 995941 ctagatatta gtatctggta ctaaaaagaa ggttttttta caaaaaaaga gaagtgtaga 996001 taggaatcta tgaaaaagaa aaaggaggct gaaaaatggt cagtcaagaa gcagtagtct 996061 ttttggcatt atccggggct attgcgtttc tgttgccaat cgggctgatt gtatggttta 996121 agcgaaagta tggtgcctcg cttaaagtgt tttttattgg cgctctcacg ttttttgtct 996181 tcgctcagct gctggaaggc ggcgttcatg tttatgtact gcaagtgaat gaaatgacga 996241 aagaagcgat gcagcatcca ttatggtatg gcatttacgg ctgcttgatg gccggcattt 996301 ttgaggagtg cggaaggtat ttgatgatgc gattttttat gaagcgccat catacttggg 996361 cagatggtct ggctttcggg gcaggccatg gcgggcttga agccatcctg attacaggct 996421 tgtcctctat ctcacttatt gtatacgcat ttgcaatcaa tagcgggacg tttgaacagc 996481 ttttggtcaa tggcgacgtc aaacaggcgc ttttgccgat acaggagcag ctgctgcata 996541 ctccttcgta tgaatggatg ctgggcggaa tagaaagaat cagtgccatt gccgtccaga 996601 ttggtctgtc tctgcttgtt ttgtacgcgg ttaaaaaccg ccggccgctg tttttgctgt 996661 attctattct tttacatgca ctgtttaatg tcccggcggt tttatatcaa agaggaatca 996721 tagagcatgc tgcagctgtt gaaatcattg ttgctcttat agcggcttta tcagtttatt 996781 ggattgtaaa agcaaaaagg gtgtttcaat aaaaggtcca agcagcagca atgcccgctt 996841 ggaaaaatgt gaatggaaat attcattaag catgggtcat cagaatattt ctgattcagt 996901 ctttagcaat gacagcaaga atgtctgtgt tttttacaag agaaacaatg gtgtttcttt 996961 ttcttcttct cgcaagggtc atggcattct ttctttttct tgcaatggtc gtggaaatct 997021 ttatcgaacc actcgtcaaa gaaccaaaaa tcatcgaacc aatcgtgaca acgacatttc 997081 tgttcatgtg aatgacgaca gcacatagaa atccctcctc ttcccatgct ctctacagca 997141 tatgagagat tgataggaaa agattggacg ggtccctcgg gaaaagagta tattttaagt 997201 agaaaataaa aggaggaatg ccctatgacg tccgtacgta aaacgatgga gctcattaaa 997261 gaacttgtat cgatcccaag cccgacagga aatacatatg aggtgatcaa ttatattgaa 997321 agccttttaa aagaatggaa ggtagaaacg gttcggaacc acaagggcgg cttaattgca 997381 acgcttccag gacgcgacac atcccggcat cgcatgctga cagcgcacgt tgacaccctc 997441 ggcgctatgg tgaaggaaat taaagcggac ggccggctga aaatcgactt aatcggcggg 997501 ttccgctaca actcgattga gggggagtat tgccaaattg aaaccgcctc gggaaaaatg 997561 tacacaggca caatcttaat gcatcaaacg tctgtgcacg tatacaaaga cgcgggaaag 997621 gctgagcgga atcaagagaa tatggagatc cgcctagatg aacctgttca ctgccggaaa 997681 gatacggagg agcttggcat tggcgtcgga gactttgtgt cgtttgatcc acgtgtcgag 997741 atcacatcaa gcggatttat taaatcgcgc catttggatg acaaagcaag cgtcgcctta 997801 ttgctccgct taattcatga aattcaaaca gaagacattg agctgccgta tacaacccat 997861 tttcttattt ccaataatga agaaatcggt tacggcggga attcgaatat tcctcctgaa 997921 acagttgaat atttggcggt tgatatgggc gctatcggtg acgggcaggc gacggatgaa 997981 tattcagtat caatctgtgt gaaggatgcg agcgggccgt atcattatca gctcagaaag 998041 catttagttc aattagccga gaagcatcat attgactata agcttgatat atatccgtac 998101 tacgggtctg atgcgtcagc agcgatcaaa tccgggcatg atattgtgca tggcctcata 998161 gggccgggaa ttgacgcttc ccatgcattt gaacgcaccc ataaatcatc tcttcgccat 998221 accgctaagc ttctgtatta ctatgtacag tcaccaatgg tataaggggg aggaccaatg 998281 aagatttata agctgaaaag cacattcggt tgggaaggtg atgacgggtt gggagaacag 998341 ctgattcagc agatccttgc cggagaaaaa agcgccacgt gcgcgccgaa atcattgtat 998401 tcaaaagatg aattgaggga cgtttatcaa acagcgggtc agcttgttac cgtttatgat 998461 aaacatgaca atccaagatg caatataaaa gtaacagatg tctttgaaac cacctttggt 998521 gcgcctgata tgaggttagt caaaggagag ggcaatggag accgaattga ggagtttcaa 998581 gaggatcatc ggatggcatg ggcggaactg atcaaaagcg gtgaactgga gctgaatgag 998641 gatactgttt tgattacaga gttgtttgtg cttgttaaag attaaaaaag cctgcggggc 998701 aagaaccccg caggcttttc attaaccaga aatggttgcg ttttgttctg ttttcgattg 998761 ggacataaca gtttctgctt tcgcaggatt aaacatgcct tcccatttag acatcacaac 998821 ggcagcaagc gcgttaccag tcaggttgac aactgtacgt gccatatcca tgatgcggtc 998881 tacgccggca ataaaggcaa gtccttcagc cggaacgccg atggtgccaa gcgttgcaag 998941 caagacaaca aaagaagtac caggtacggc agccatccct ttggatgtca ccattaagac 999001 gagcacaagc gtaatttggt gccaaatcgt caaatcaatg ccatatacct gtgctaaaaa 999061 gagtgcggca atagattgat agagaacgga accgtctaag ttaaacgtgt aaccgatcgg 999121 aatgacaaat gaaacaatgc cttttggaca tccgattttc tccatttttt ccatgatacg 999181 cggaagaacc gtttcagagc tggacgtact gaacgccagt aagatttcgt ccttcatgta 999241 agcaaggaac ttgaagatgc tgatgccggc aatttttgcg acaatcccga aaataacaat 999301 taagaagaaa gcaagcgcga cataaaccaa tccgacgagc tttccgagag agataagaga 999361 accgagtccg aatttagaca cagtcactcc gataagagcg aaaacgccga atggcgccac 999421 tttcatcaca aggtttacaa cgtggaacat ggcatgggat acaccttcaa aaaaggctaa 999481 tacaggcttg cctctttcac cgatcgcgga aatacccaat gcaaatagta ctgtaaagca 999541 gatgatggct agaagatccc cttcgaccaa tgactggaag aagtttgtcg gcacaatatg 999601 gaggaacgtt tccgccactg atttattact ttgttctttt tcagtttcaa catattgact 999661 gatgtccgat ttttgagctt cgtgtatatt aactcctgta cccggatgga agatgtttgc 999721 aagggctagt ccgagaataa tggcaaaagt cgtgatgatc tcgaagtaca gaatcgttct 999781 gaagcctaat ttaccgactt gctttccatt tcctgcaccg gctacaccga tgattaagct 999841 ggagacaaca ataggaatca ctatcatttt gattaagcgt aaaaagagat ccccgattgg 999901 ctgcaggtaa gtaggcaatg ctgggttgcc ataccaaatg acgccaacaa tgacacctag 999961 aataagtcca acgaatattt gtgtggctaa tccaaactta attcttttca tagattacct 1000021 cccaaaaaac aaagtatcaa catatatcat gaatagacat atatttaatc tcactattag 1000081 atcaaattat aatagataag aaatcaattc gtctatagta aattatattt cgaaaataaa 1000141 gaatattcaa tgacattatg ataatcacca gaattatcta aaaacaggtg agctttgacc 1000201 taacctgact attatttcaa aattaagaga tatgtgaaaa aataagaaaa tcccacgcgt 1000261 aaggcgcggg attttcgctc attacaaatc gtttactttt atacagtcat tgcagatatt 1000321 accataacac tcatgctgct cttctatctt ttttccgcat tccgcacact ttttcgaagg 1000381 caggtttcta aaaaattctg tgattttccc cagcataacc aatccctctt tcccctttgt 1000441 agtgatttca ttgtaatata acagattaca aaaatcaata actgttttga tacaatgttt 1000501 aaaacatgct tttttcaaga aaaatgggta tattgaagga ggaccaattt ttttgaaaag 1000561 ataggaggac attatgaaag ttacagttat cggatgctat ggcggttttc cggccgcaaa 1000621 tgaagcgacg tcaggctatt tgtttcagtc aggtgattac tctctgcttg ttgattgcgg 1000681 cagtgccgta ttgtctaagc tgttcggata tgtgccggcg gaaaagctgg atgcggtcgt 1000741 tctgtctcat tatcaccatg accatatcgc tgatatcgga ccgctgcaat ttgccaagca 1000801 agtcggttcg tttctcggca aaggagagca tacgcttccg atttacggac atgatgctga 1000861 tatagaacag tttcaaaagc ttacatataa aacacataca aaagggatcg cctatcagcc 1000921 ggatcagccg ctgactgccg gtccgtttac gatcaccttt ttaaaaacga ttcacccggt 1000981 gacgtgctat gccatgcgga ttactgacgg cagccacact gtcgtttata ctgctgattc 1001041 cagctatcag gattcattta taccgttttc gaaagatgct gatttattga tctcagaatg 1001101 caatttttat gccgatcaag acggaacaag tgcaggccat atgaacagcc tggaagctgg 1001161 gcgcattgca aaagaagccg gagcgggaga actgctgctg acacatttgc cgcattttgg 1001221 cgtgcatgac aaccttcgca aagaagcgaa aaccgttttt aacggagaag tgaatattgc 1001281 gaaatcaggt tttgtgtggg aaggataaag gaggagcacc atgttattta tagacaatca 1001341 aaatatcaat gatccgcgga tcaatcttgc tatcgaggag tactgtgtaa agcatttaga 1001401 ccctgaacag caatatttgc tcttttatgt gaatcaaccg tctattatca ttgggaaaaa 1001461 ccaaaataca atagaagaaa tcaatacaaa atatgttgag gaaaacggga ttatcgtcgt 1001521 ccgccgttta tcaggcgggg gcgctgtgta ccatgatctg gggaacttga acttcagctt 1001581 tattaccaag gatgacgggg acagctttca taactttaaa aaattcactg agccagtgat 1001641 tcaggcgtta catcagcttg gggttgaagc cgaattaagc ggccggaacg acattgtagt 1001701 agatggccgg aaaatatccg gaaacgctca gtttgcaacg aaaggccgta ttttcagcca 1001761 cggcaccctc atgtttgatt cagccattga tcatgttgta tcagcattaa aggtgaaaaa 1001821 ggataaaatt gaatcaaaag gcatcaaatc gatcagaagc cgagtggcaa acatcagtga 1001881 gtttctcgat gataaaatga ccaccgaaga attccgcagc catttgcttc gccatatttt 1001941 taacacaaac gacgttggaa acgtgccgga gtataagctg acggaaaaag attgggagac 1002001 cattcatcaa atttcgaaag agcgctatca gaattgggat tggaactacg gccgctcacc 1002061 aaaatttaac cttaatcatt cgaagcgtta tccggttgga tcgatcgatt tgcacctgga 1002121 agtcaagaaa ggcaaaatcg aggactgcaa aatcttcgga gatttcttcg gtgtcggtga 1002181 tgtatctgaa attgaaaacc tgctggtcgg aaaacaatac gaacgcagcg tcatcgctga 1002241 tgtgctcgaa ggtgtgaatc tcaagcatta ctttgggaac attacgaaag aggatttcct 1002301 tgatctgatt tactaaggca aaacacatcg tttgaaagag cggttgtgtt tttgaaataa 1002361 tggaggcagg agggattcac atgaaagtgt ttttaatcgg agcgaacgga caaatcgggc 1002421 aaagactcgt ctctttattc caagataatc ctgatcattc catcagagcg atggtcagaa 1002481 aagaagaaca gaaagcgtct cttgaagctg ccggtgcaga agctgtgctt gcgaatctgg 1002541 agggcagccc ggaagaaatc gccgctgcgg caaaaggttg tgacgcgatc attttcacag 1002601 ccggttccgg cggcagcaca ggctatgata aaacgctgct ggtggatctt gatggagcgg 1002661 caaaagccat tgaagctgcg gccattgccg gaatcaaacg gtttattatg gtcagcgccc 1002721 tgcaagccca taaccgtgaa aattggaatg aggcactcaa gccttattat gtggccaagc 1002781 attatgctga taaaattctg gaagcgagcg gtttaaccta tacgattatc cgtccgggag 1002841 gccttcgcaa tgagcctgga acgggaactg tttcagcagc gaaggatctg gagcggggat 1002901 ttatttcccg tgatgacgtt gcaaaaacgg tcattgcctc tttagatgag aagaatacgg 1002961 aaaatcgggc ctttgatctg acagaaggag atacgccgat tgccgaagca ttgaagaaac 1003021 tatgacagta ctgacactca gggctttttg ctcttgagtg tttttttctg tttctctata 1003081 atggagaaga aagcttggct tcaataatga atgactattc attcacttaa ggggtgggag 1003141 aatgaatctt gtttcaaaat tggaagaaac agcatctgag aagcccgaca gcatcgcatg 1003201 caggtttaaa gatcacatga tgacgtatca agagctgaat gaatatattc agcgatttgc 1003261 ggacggcctt caggaagccg gtatggagaa aggggaccat ttagctttgc tgcttggcaa 1003321 ttcgcctgat tttatcatcg cgttttttgg cgctttaaaa gctgggatcg tagttgttcc 1003381 catcaatccg ttgtacacgc cgacagaaat tggttatatg ctgacaaatg gcgatgtaaa 1003441 ggcaatcgtg ggcgttagcc agcttttgcc gctttatgag agcatgcatg aatcgctgcc 1003501 aaaggttgag ctcgtcattt tatgccagac gggggaggcc gagccggaag ctgcggaccc 1003561 agaggtcagg atgaaaatga caacgtttgc aaaaatattg cggccgacat ctgccgctaa 1003621 acaaaaccaa gaacctgtac ctgatgatac cgcggttatt ttatatacgt caggaacgac 1003681 tggaaaaccg aaaggcgcga tgctgacaca tcagaatttg tacagcaatg ccaacgatgt 1003741 cgcaggctat ttgggaatgg atgagaggga caatgtggtc tgcgctcttc ccatgtttca 1003801 cgtgttttgt ttaaccgtct gtatgaatgc accgctgatg agcggcgcaa ctgtattgat 1003861 tgagcctcaa ttcagtccgg catctgtttt taagcttgtt aagcagcagc aggcgaccat 1003921 ttttgccggt gtgcctacaa tgtataacta cttgtttcag catgaaaacg gaaagaaaga 1003981 tgatttttct tcgatccggc tgtgcatttc gggaggcgcg tccatgccag tcgcgttgct 1004041 gacggcgttt gaagaaaaat tcggtgttac cattttggaa ggctacgggc tctcggaagc 1004101 atcacccgtc acgtgcttta acccgtttga caggggcaga aagccgggct ccatcgggac 1004161 aagtatctta catgtcgaaa acaaggtcgt agatccgctc ggacgcgagc tgcccgctca 1004221 ccaggtcggc gaattgatcg tgaaaggccc caatgtgatg aagggctatt ataaaatgcc 1004281 gatggaaaca gagcatgcat taaaagacgg gtggctttat acgggggact tggcaagacg 1004341 ggatgaggac ggctattttt acattgttga ccggaaaaaa gacatgatca ttgtaggagg 1004401 atacaatgtg tatccgcggg aggtggagga ggtgctgtac agccatccgg acgtcaagga 1004461 ggcggttgtc atcggcgtgc cggaccccca aagcggggaa gcggtaaagg gatatgtggt 1004521 gccgaaacgc tctggggtaa cagaggagga catcatgcag cactgcgaaa agcatctggc 1004581 aaaatacaag cggcctgccg ccattacgtt tcttgacgat attccgaaaa atgcgacggg 1004641 gaaaatgctc agacgggcac tgagagatat tttgccccaa taaaatgaaa aagcgaagcg 1004701 gttagcttcg ctttttcatt ttcaatcctt tgcttctttt ttaataatat ttagcagcgc 1004761 ctttgtatca tttttgctta atttgtagta tgtgccatcc ttcaaaaaaa cggcttgctg 1004821 gctgccgtca atccatagtc tgaatgagtc ataccggtct ttatgaaact tgattgtccc 1004881 ttcgtaatca ggggctgatg ttttttctgt cttcacctgt tttccctgat tcataatatc 1004941 cagcatatct ttgacgtgct gtcttttttc aatctcgata tcttcctggc cgcttgaaga 1005001 cagtgtgatc aaatccgcgt ctaccgattg atacacatcg cctgatcggc tgtaaagata 1005061 aaaaaatgcg ataaacacaa gaccgattac cacgatggct gccactattt ttttcatttg 1005121 catcactcca aacattgtta gttttcccag cgatcggggt ttccatgctt aaaagggtgg 1005181 aaaagtgcgg aacacagctt ggttctaaga atttgaattt atgattacaa tagaagtaac 1005241 gggttgatgt gaggagtgag gcgttatgcg caagtggatt gcggcagcag gacttgctta 1005301 cgtgctgtac gggctgtttt tttattggta ttttttcctg tcgggtgatt ccgcaatacc 1005361 ggaagccgtg aaagggacgc aggctgatcc ggcttctttc atgaagccgt ctgagttggc 1005421 agtggccgag cagtattcga atgtcaagaa ttttttattt tttatcgggg taccacttga 1005481 ttggtttctg ttttttgttc tgcttgtcag cggtgtttca aagaaaatca agaaatggat 1005541 cgaagcggcc gtgccttttc ggtttttgca gaccgttggt tttgtgtttg tgctttcgct 1005601 gattacaaca ttggtgacgc tgcctttaga ttggataggc tatcaagtat cgcttgacta 1005661 taacatttcc acacagacaa cggccagctg ggctaaggat caggttatca gcttttggat 1005721 cagctttcca atctttacgc tttgcgttct cgttttttat tggctgatca aaaggcatga 1005781 aaaaaaatgg tggttatacg cctggctgtt aacagtgccg ttttcgctgt ttctgttttt 1005841 tattcagccg gtcattatcg atcctttata caatgatttt tatccgctga aaaacaaaga 1005901 gcttgaaagc aaaattttag agctggcaga tgaagccaat attccggctg accatgtata 1005961 tgaagtgaac atgtcagaaa aaacaaatgc gctgaatgcc tatgttacag gaattggggc 1006021 caataaacgg attgtattgt gggatacgac gctgaacaaa cttgacgatt cagaaattct 1006081 gtttattatg ggccacgaaa tgggccatta tgtcatgaag cacgtttaca tcggtctggc 1006141 tggctatttg ctcgtgtcgc tcgccggatt ttatgtcatt gataagcttt acaagcggac 1006201 ggttcgccta acccgcagca tgtttcattt agaagggcgg catgatcttg cggcacttcc 1006261 gctgttattg cttttgtttt ctgttttgag ctttgcggtt acgccttttt ctaatgctgt 1006321 ctcgcgttat caggagaata aggctgacca gtatgggatc gagttgacag agaacagaga 1006381 agccgctgtt aaaacgtttc aggatttggc cgtgacgggg ctgagccagg ttgatcctcc 1006441 ggtgcttgtg aagattttca gaggcagcca tccgtcgatc atggaacgga ttcaacatgc 1006501 ggagaaagaa gagaatgcgc cggaacatca ggatgctgac aaataaaaag aagcaggtat 1006561 ggaggaacct gcttcttttt actattattg tgcagctgct tgtacgttga ttaacccttt 1006621 tccatagtag aaagagtttc caagatatgt tgcagtgctt tctaaacgat cacggacttg 1006681 cgcgtttgtc caagtcgggt gcttagaaag aattaacgct gctgctccgg caacgtgagg 1006741 agtcgccatg gacgttccgt tataagcgcc gtaagtgcct ccaggaagtg tgctttggat 1006801 ggacacgcca ggagccatca catcaagctc agaacctgcg ctggagaatg aagctctttg 1006861 gttgctgctg tttaccgcac ctactgcaat agtagaagga tattttgcag ggtagccgac 1006921 tgtgcttgtg cttccggatg aaccttcgtt tccggctgcg gcagcaacga cgataccgct 1006981 ggaaacggct ttgtcaacga ctgttttcag cgctgtagaa ccagtaggtc cgccaaggct 1007041 catgttgata acatccatat tgttggaaat ggcccactca atgccgttaa taatccagct 1007101 atattggccg cttcctgttg aatcaagcac ttttactgca tataatgatg cgcttggcgc 1007161 tacgcccaga acaccgattg agttattaag agcggcaatc gtaccggcta catgcgtacc 1007221 gtgagaactg ccgtcctggt atgggtttgt ttcagaaggt acgaagcttg ctccgcctct 1007281 gacgtttaag tcaggatgag aagagtcaat tccgctgtcg ataacagcta cttttacgtt 1007341 agagcctgtg tagccttgag agtgaagagc cggcgcttta atttgagaaa tgccataagg 1007401 aacagattgc gcatattcat gtgcaatatg atcttcttcc acatatgcaa cgctcggatc 1007461 ttttttcaat tcttttacag ctttttcatc caatgttgct gcggccgcgt taacatactt 1007521 aaattgcttt tgaacctttc cgcctttttc agaaataaca tcctttttct tggcggaact 1007581 catggcactc attgtctgtt taaatccgac aatgtatttc ttttctgtac tgctttttcc 1007641 ggcagcctgc gcagacatgt tgctgaacgc catcgtaaag attaacgtta acgcaaacaa 1007701 caagctgatc cacaattttt tgcttctcac tctttaccct ctccttttaa aaaaattcag 1007761 agtagactta cttaaaagac tattctgtga atttattgta atagatggaa taatatttta 1007821 gtagacccat ttttttgaga tgattttatc tctatttagg tatatcatct ctcgctattt 1007881 ccgtagagac tcgaaataac tattttcata cagaaaagaa cgaaaataga catgagtaaa 1007941 tgttcattat gctgaaatgt catgcttttt taggttaaat gctcctgagt cccggcaaat 1008001 tcctgtcgaa aaaattcgtt caaatgacct gcgtgtgctt ccgtgagaac aatggatatt 1008061 atcgtgatat tttttcaaag catgatgata aaagtattct gaaaaataaa ctttacagaa 1008121 aagggataga atgaaaaaat tattgagagg gaggaagaaa taagatgaac attcgccaag 1008181 caaagacatc agatgcggcc gccattgcgc cgctgtttaa ccaatatcgg gaattttata 1008241 gacaggcatc cgatttgcaa ggggcagagg cttttttgaa agctcgtttg gaaaatcacg 1008301 agtctgttat tttgatagca gaagaaaatg gagaattcat aggctttacc cagctctatc 1008361 caacgttttc ttctgtgtca atgaaaagga tatacatatt aaatgactta tttgtcgttc 1008421 ctcatgcgcg tacaaaggga gccggcggcc ggctgctttc tgccgcaaag gattatgcag 1008481 ggcaaaacgg ggcaaaatgt ttaacacttc agactgagca ccacaaccgg aaggcaagaa 1008541 gcttgtatga gcaaaacggc tatgaagagg ataccggatt tgtccattat tgtctcaatg 1008601 tgccggcgaa gtgaaaatgg cggcttgatg atttggtttt ttgaacgttc ttcggttacg 1008661 atataaatga aaaggagtgt gccgaatgtc aacgttattt caagccttgc aggcagaaaa 1008721 aaatgccgat gatgtttcag tccatgtgaa aaccatatca acagaggatt tgccgaagga 1008781 tggtgtcctg attaaagttg cttattccgg cattaattac aaagatggtc tggccggaaa 1008841 agcaggaggc aatatcgtca gagagtatcc gcttatttta ggcattgatg ctgcgggtac 1008901 ggtcgtctct tccaatgatc cgcgttttgc ggagggggat gaggtgatcg cgacaagcta 1008961 tgagctcggt gtctcacgtg atggcggatt aagtgaatac gcttcggtgc ctggtgactg 1009021 gctggtgcct ttgccacaga atctttcgtt aaaagaagcg atggtgtacg gaacggcggg 1009081 atttactgcg gcgttatcag tgcatcggct tgaacagaac ggtctgtctc cggaaaaagg 1009141 cagcgtgcta gtcacaggag caaccggcgg tgtcggcgga attgcggtat cgatgctgaa 1009201 caagcggggt tatgatgtgg tggcaagtac cggaaaccgg gaggcggctg attatttgaa 1009261 acagcttggt gcaagcgaag taatcagcag ggaagatgtc tatgacggaa cgcttaaggc 1009321 gctgtccaag cagcaatggc agggagcggt tgatccagtc ggcggaaaac agcttgcctc 1009381 gcttttaagc aaaattcaat acggcggatc tgtcgcagtg agcggcttaa ccggcggagg 1009441 agaagttccg gcaaccgtgt atccttttat tcttcgcgga gtaagcctgc tcggaatcga 1009501 ttcagtatat tgtccgatgg acgtcagagc cgctgtttgg gagcgcatgt cttctgatct 1009561 caagcctgat cagctgctga ccatcgtgga cagggaagta tcattggaag aaacgccggg 1009621 tgcgttaaaa gatattttgc aaaatcgcat tcaaggaaga gtgattgtga agctttaaca 1009681 ggatcagctt gcagagaatg ttatttttct gcaagctttt ttgtggacag gatgatcagc 1009741 tgctgaactg ctgtgtcgcg aaacaagatt ttcctgtaag ccgaactttc tcttctcatt 1009801 ttaaaaataa ttggtgataa tgattctcat tccgtgttat actactcttg gacatcttaa 1009861 ccatagaaac taccaacagg agagactgga acatatgaaa aaaacactga ttattcttac 1009921 agttttactt ctttctgtct taacggctgc ttgctcgtct tcaagcggca atcaaaacag 1009981 taaagaacat aaagtggcgg taacacatga tttagggaag acaaatgtgc ctgagcatcc 1010041 gaagcgggtt gttgttcttg agctaggttt tattgataca ctgcttgatc tcggcattac 1010101 gcctgtcggg gttgccgatg acaacaaagc gaagcagctg atcaacaagg atgtgctgaa 1010161 gaaaattgac ggctacacat ctgtcggcac tcgctcacag ccaagcatgg aaaaaatcgc 1010221 ttcattaaaa cccgatttaa ttattgctga cacgacccgg cataagaagg tgtacgatca 1010281 gctgaaaaaa atagcgccga cgattgcact taataattta aatgctgatt atcaggatac 1010341 aattgacgct tcgcttacga ttgcaaaagc agtcggcaag gagaaggaaa tggagaaaaa 1010401 gctgacggcg catgaagaaa agcttagcga gacaaagcag aaaatcagcg cgaacagcca 1010461 gtccgtgctt ttgatcggaa atacaaatga taccattatg gccagggatg aaaacttctt 1010521 tacatcgaga cttttaacac aggtcggcta ccgatatgca atcagtacgt caggcaatag 1010581 cgattcaagc aatggcggcg actctgtgaa tatgaaaatg acactggagc agctgctgaa 1010641 aacagatccg gatgtgatca tcctgatgac aggaaaaaca gatgacctcg acgccgacgg 1010701 taaacgcccg atcgaaaaga atgtcctttg gaaaaaactg aaggcagtga aaaacgggca 1010761 tgtataccac gtggatcgtg cggtgtggtc tctgcgccgc agtgtagacg gggcgaatgc 1010821 cattttggac gagcttcaaa aagagatgcc ggctgctaag aaataaaaga aaagacaggc 1010881 aaacgcctgt ctttttctta tttgataaag ccggataagt ggctgttgat attatagtct 1010941 tttatccgcc atttttcttc tgcaaattca atgttgctga ggcaggcgtt gacgagacgg 1011001 gtgctttgaa gctccgggtc accgccggat atttctgtca gcagggcgtg aattgccgca 1011061 ccgtgcgcca cgatcagcac cttcttgttt ggatacgcct gattcacttt tgccaaaccg 1011121 cccatcagcc tgtcagtgag ttcttctaag gtttccatat tcggatagat gttatctgga 1011181 tagcgctttg tccgttcctc cagcggcatg ccctccgcgt cgccgtaatc gcgttcctta 1011241 aaatcatcca tctcgactat cggaagatgc agatattcat taataatttc cgcggttctt 1011301 ttcgctcttt tcagcgggct cgtcacaata atatcccaag aaaagtcctt tacatattct 1011361 ccggtttctc ttgcttggcg ttcacctgtt gcgtttagcg ggatatcggt tttgccttgg 1011421 catttttgct gcaggttcca atcggtttct ccatgtctta ctaaacaaac ggctgtcata 1011481 aaatcccctt cctgacttta ttcatatcgc tattatacta aatcgaaagc gtgtgtccta 1011541 tgaaaaagcc tatgcaagaa cttcaaataa taaagccagt ccgattccgc cgccgcttcc 1011601 gatggctgca acagcatatt gacagtctgg ccgtcttttc gcttcataaa acaatctggt 1011661 taccagagct gcacctgatg caccgtacgg atggccaaga gctaaggcgc cgccgcgcac 1011721 attgattttt gaaaagggaa tgccgagttc ttgcgagcag acacaaattt tgacggcaaa 1011781 ggcttcattg atttcaaata aatcgatatc atcaggtgtt acatcgtgtg tatgtaagag 1011841 ctgacgaatc gcgacaaccg gtgccgcggg cggaaagttg gggtgaatgc cgctgacagc 1011901 gctgccgata aaccgaagca caggcttaag tcccagggct gctgcttttt cttcttccat 1011961 taccaaaaga gcggctgctc cgtctgctat gccactgctg ttggctgctg tgactgttcc 1012021 ggagctggtg tcgaaaaccg gctttgcacg gggaataatc gcttctattg gccgcgtttt 1012081 caaaaatgct tcgtccgtct ccaattcccc gagagcaaca acttcttcac ggtaaaatcc 1012141 ttcatcatgc gcgttcctgc tgcgttgatg gctgagaagc gcgtactcat cctgcatgct 1012201 tctgctgatg gaatagcgtg cagccgtata ttctgccgca atgcccatgt ctggatcgcc 1012261 gatcgcatct ggagaaaagc gagcccgttc tgaaaaaggg gattggctgc tgctttctga 1012321 gccgcccgcg atatacatcg tgccggctcc cgcttgaata aggctgcagg catagcgcac 1012381 agcttcaagg ccggagccgc actgtctgtc aattgtcatt ccgggaaccg ataaaggcag 1012441 tccggcttga agggctgaca gtctggccag gttgccgcct ctgccagtag cgtttccgag 1012501 aatgacctcg tcaacttgat cctctagctt tcggctgaga cagcggatga tgggagccgc 1012561 caaatcctcc ggcaggaagg gcttcagcag tccgttttga tttccaaaga tcgttcgttt 1012621 tgcatcaaca ataaccgcat tcatttatac tgtacactct cttccagcca ttttttcact 1012681 ctggaacggg caatttttcc gctgctcgtt tccggcaagc tgtctgcaaa cacccatttt 1012741 ttcggaattt tataggaggc taatttctgt ttacaccagg ctttcagtgt tctggcatta 1012801 gcgtttccaa gaatgacagc tacagcgatt tctccccaat actcgtcggg aatgccaacg 1012861 acagccgcgc tttcaacctc tgggcaggcg agaagcacac gttcaatttc ttctgggaaa 1012921 atatttaatc ctccgtacac gatcatcccg ttttctcttc ctgatatgta tagaaagccc 1012981 tcttcatcaa cgtagcccat atcatctact gtcatccatt catctggtgt gctgccgttc 1013041 acatagccgg aaaacctcat cgggcttttg acaaatattt ttccgatttc tcctggctgg 1013101 cagcgttctc ctccagcgtt gcggatttcg atccggacat tatgaaaagg gcggcccgct 1013161 gaatgcggct tccgtttgct gtcttccggt gaagaaaacg tcacaaaact aagctctgat 1013221 gtgccgtaaa aatcgtacag cttgagatga ggccatgcag cggcaagctt cttcttggat 1013281 tctgccggcc agtctgcgcc ggatgaaatg attttgacgg gactgtcggg aaaaccctca 1013341 atccttgcga gggcgtctgt catcgtcggt acggtataga gaacactgat ggattcacgg 1013401 cacagccatt ccttcgcttt ggcaggagaa aactttttca gcaaacaaac ggttcctccg 1013461 agaaacaaag tgctgacagc cccatatagg aagtgagagg acattaacgc tccgggaatc 1013521 agaaccttat catctgatga aatcgaaaaa tctgtttctg tacaggtaaa gctctccatc 1013581 catgagcggt gagatcgcgt aaaggccttc ggttttcctg tcgagcccga cgtaaatccc 1013641 atataaaaag ggtgctccgg atcaatggta ggcaagggat cagcggctgc ctcagaaata 1013701 tctgccatac agttatccag caatacaaca ggtgtctggc tatctgtcag tttgtttttg 1013761 aaaaaggcta aagtaaccac aagatccgca ttgcttatgg acagccgctc cttacattca 1013821 gccgggctcc agcgtgtgtc gatgggaatg gccgtacatc cagccgctgc ggctccggca 1013881 aacagctgta aaaacgcgag actatttggg agcaggatcg ccacacgatt cggcatgctc 1013941 ggctgtgacc gcagccaatt tgcggtttga gagacaagcc gatcccaatc atggtacgtg 1014001 atttgctccg attcagtctg gatcgctaca cggccgggcg atgtttcggc agtagatgaa 1014061 taggtatgag taattgtcat gtattgtcat cctccttttg taaacatcgt atcagaaaga 1014121 gacaaggctt gagtgatttt tatcgccaga aatgcagata cagccgcttt tatcaaatca 1014181 ccaggcacat atgcaaggct catgaaggcg gcctgtgaca aatcaatatg catgataaaa 1014241 gcttgtaccg gtataccaag cagataaata aagatgatgc cgaatacgat atgagtgaaa 1014301 aagagacgca atactgtcac cttccgcagc ctgttagcgg ctaaactgat cagccatgaa 1014361 gcgaggggat aagcaatcaa aaagcctgcg ctcggtccga aaaacacacc aaaaccgcct 1014421 cgtccgccgg gcaacagcgg cgctccgaag gcgacgagca gcaaaaagac aagctggctt 1014481 aagaaagcag actttggcct gagaatgctg cctgccaaca tgacaccaag cgtttgcaat 1014541 gtaatcggaa cgggtgtaaa ggataagaag agagggggca taaagccgag cactgccatc 1014601 agcgcggtga aaatcgcaat atgcatcatg tcgattaatt tcagcatgtg aaatcctcca 1014661 aaaagtaatc aaatatggtt atacaataaa tgcaggtaat tattatgtca actgattttt 1014721 aatttaagtt tacataatga acgcaaaaaa accggccgta tggcagaccg gtttttgatg 1014781 gttattcttc tgtcaggatg acaagcgaat caacggaagc ggccacatgg gaaacggcgc 1014841 ggctgacttc ctgaagccct ccaagaaagg cttgcagatc gacgtcgatt ttgcctgatt 1014901 gctctttgct gattttcatg ctgtggacga tttcatcgaa taagcggtta atttgcgtca 1014961 ttttttcttt actttcgctg actagctcat tcacgtcttt gatatgcttg gatacaatgt 1015021 tgatttgtgt attcgtattg ttcacaagct cagaaacagt agagacggtt tttttcgtat 1015081 cctcagaaag cttccgcact tcatttgcca cgacagcaaa gcctttgccg tgttctccgg 1015141 cgcgggcgga ttcaatagat gcattgagcg agagaaggtt tgtttgttca gctatgcctg 1015201 tgacgatgcc gaagattttt tcaatttgct gcgcgatttc atccagcttg accatttctt 1015261 tttcgatttg gacaaggctt gtgtcaattt tgttcatctg tttttgctgg acttctagct 1015321 ctttttttcc gccgatcgac ttttcttcaa cagtgctgga tgttacagtg ccggctttgg 1015381 atgcttgaga aatgccttca gatttgtcca caagctcttg aactgatctg cttgtttctg 1015441 aaaacagatt ggcaatcgat ccagaggttt cttgaatttt ctgatgaaga aggtttttct 1015501 tttcttcttg ttcatcacgg gtctggttgt actcgctttg aaacgcttca aggacaagct 1015561 gctgttctaa gttcaagatt tttgttgttg ctttaatggc ttttagcagt tcttgctgat 1015621 ttgtaatgga cgcttcataa atgtcaatca ttgacaaaag gagctcttga aacgcaccca 1015681 tataccattt tggcaaaagg ccgattctta aatggatgga ggcgattcgg ttacgctttt 1015741 caataaattc atcatcgata acgcctgcaa acatttcctg aatatgccgt tttaacgttt 1015801 gttttaagcg gtcaactgag ctgtgatcat taatgatatc catcaatgag ctttcatggt 1015861 caaggttttt ataaaacgca tcgacgatat ttacgatatt ttcttgaatg agtggctgaa 1015921 gctgctctaa cacataaagc tcagcatctc ccaacctgac cattttgagc tgttttttga 1015981 catctgcatg tttgtttgtg agctgaatgc ggtttttttg ttgtccgttt gaatctgaaa 1016041 agtaagctgt ttcttgtttt ctgtcttttt taaataacaa tacaatgatc ccccttggga 1016101 aaaatataat ttttactttt tggcttttta agcctttttc ttttttatcg gccaagggaa 1016161 acatgaatga agctgcagat gaaaaatatt tgaaaaaacg ttcattaaaa tgaacggttt 1016221 aatcgagatc tatttgtttt aatggtttaa tggccggacc ctctacaact tcgccagatg 1016281 gcttaaagcg tgatccgtgg cacggacaat cccacgtatg ctcactgtcg ttccactcga 1016341 cctcgcagcc taaatgggta caagtcgtat caacgagatg gaggcagcct gtctcatcac 1016401 gaaatgctcc cgctcgcctg ccgtttatgg tgacggcttt cccttctcct ggcgaaatgt 1016461 cttcaaattg gacatcaggc ttttcaagct ttccttttat caaatgcttg gcgacatctg 1016521 cattgtagga aatcactttc tgcaacccgg gattcagatg gaaacgggac ggcgtgaaaa 1016581 tgctttcgta tgggttttct tttttctcca caaggtctga caataaagtg gctgcgactg 1016641 ctgaggacgt catgccccat tttttgaacc cggtcgctac tagaatattg tcctcatttt 1016701 ccgacatcgg cccgataaac gggattttgt cgatcgtcac tagatcttgg gtggaccaat 1016761 aatatggaat gctttcgatg ccgatggtgc tttcggccag ttgtctcagt gtttcataat 1016821 gtgtagacat ggcttttccc tggcctgttt tatggcttac tccgctgaag agaatcagct 1016881 tttcaccgtt tacaaccgta tagcggagcg ccactgacgg ctgatcgata ctcaaataca 1016941 tgccctcggg atactcgatc ttcggcttga tggcaaggac ataagatctg tcggagtaca 1017001 ttctcgcagc atataatccg cctccgtcat aaaaagggaa gtgggaacag catatgataa 1017061 agcggctctt aatggcgtgc cggctttttg ttaccacttc gggcctttcg ccttttttga 1017121 tatcaagcgc aacggtctct tcataaattc ggccgccttt ttgaacaatt tgctccagaa 1017181 gcgcttttaa gtattgaagc ggatgaaatt gagcttgatt cttcatgaca agcgccagct 1017241 tagaacctaa gggaattgga agatccttga taaggtctct ttcaattccg agctttgtgt 1017301 atgcctcatg ctcggtgtgg attttttgaa cagcgttttc atttgccgta taaagatatg 1017361 cgtcttgctc gatccattca caatcaattt gatgttcatc cacaatgcct tttatgtaat 1017421 caattgcgtt ttggtttgct tcataataaa gcctcgcatg gtttaatccg aaatggcgga 1017481 taaattcgtc gtatatcatg tcatgctgtg cggtaacttt agcagttgta tgcgcagtgg 1017541 ttccgttaag aacctgattt gcttcaatca aaacgacacg gaagcctctc ttcgtaagtt 1017601 catatgccgt tgtgattccc gtaatcccgc ctccgataat ggtgacgtca cattcagtgt 1017661 cctcttgaag cgcaggaaaa gaaggcaggt cagttgatgt tttccagtat gtttcaggtg 1017721 cttcctttgc aaaatgttga ttagccaagc cgttatacct ccaatcagat ttattcttaa 1017781 tttttccata ttctatcttt tcatacatag gaagcaggca ttgttcataa cataataagg 1017841 ttgaaaagga gtgatttcat tggcgaatca aaaaaagaaa acattaccgc ctcagcacca 1017901 gaaccagcag cctggttttg aatatctgat ggacccgcgt ccggtttttg ataagccgaa 1017961 gaaagcgaaa aaattagagg gcaaaaccgc tattattact ggaggagaca gcgggattgg 1018021 acgcgctgtc tcggtgttat tcgcaaaaga aggggctaat gtggtcattg tgtatttgaa 1018081 tgaacatcag gacgccgagg aaacaaagca gtatgtagaa aaggaagggg taaaatgcct 1018141 gctgattgca ggagatgtcg gggatgaagc gttttgcaat gatgtggtcg ggcaggcaag 1018201 ccaagtgttt ccatccattg atatattggt taacaatgca gctgagcagc atgtccagcc 1018261 cagcattgaa aaaatcacca gccaccagct gatcagaacc ttccaaacaa acattttttc 1018321 catgttttac ttaacaaagg cagtgctgcc tcatttaaaa aaagggagct ctattattaa 1018381 taccgcttca attaccgcct ataaaggcaa taaaacgctg atcgattatt cagcgacaaa 1018441 aggcgcgatc gttacgttta caaggtccct ttcccagtcg cttgttcagc agggcatacg 1018501 ggtcaatgca gtggcaccgg gtcccatttg gacaccgctt atcccggcca gctttgccgc 1018561 aaaagacgtg gaagtgtttg gttcagacgt gccgatggaa cgcccggggc agccggtcga 1018621 agtggcgcca agctatctat accttgccag cgacgattcc acatacgtca cagggcagac 1018681 gattcacgtc aatggcggaa caattgtgaa cggataataa aaagccaatc cttgaaggat 1018741 tggcttattc gctctgcttg agcgctgcat attctttaga gagcgtaaga aacgcatctt 1018801 tatctttttc gtccaaggct ttgttaattt ggtccgtcag catggcaagc cgacggttat 1018861 acaaggattc atcgagcacc atttgaatgt aaatatccgt cattgtgaca tcgaattctt 1018921 ttgttttttg cgtgttgcgg gacttcatga gctcagtgta cgattttttc tctttcataa 1018981 agaatccccc caatgccttt tttatagtat atggataacg gtcgaaaaaa tcaataaatt 1019041 tttataattt ttagacaact aatacttggc aatctatcga catatcctgc aaaatgccgt 1019101 aaaccggcaa gtcttatgaa agtaaaatcg gtttattact agtcatttag taccattaaa 1019161 tatcattaaa agatgatttt atcttaaatg ttaaaaaaac ctgtcgtttt acaaaaacag 1019221 atgatagatt attagtataa attttgcaga aaaaggatgg aggccataat atgagtcaga 1019281 aaacagacgc acctttagaa tcgtatgaag tgaacggcgc aacaattgcc gtgctgccag 1019341 aagaaataga cggcaaaatc tgttccaaaa ttattgaaaa agattgcgtg ttttatgtaa 1019401 acatgaagcc gctgcaaatt gtcgacagaa gctgccgatt ttttggatca agctatgcgg 1019461 gaagaaaagc aggaacttat gaagtgacaa aaatttcaca caagccgccg atcatggtgg 1019521 acccttcgaa ccaaatcttt ttattcccta cactttcttc gacaagaccc caatgcggct 1019581 ggatttccca tgtgcatgta aaagaattca aagcgactga attcgacgat acggaagtga 1019641 cgttttccaa tgggaaaacg atggagctgc cgatctctta taattcgttc gagaaccagg 1019701 tataccgaac agcgtggctc agaaccaaat tccaagacag aatcgaccac cgcgtgccga 1019761 aaagacagga atttatgctg tacccgaaag aagagcggac gaagatgatt tatgatttta 1019821 ttttgcgtga gctcggggaa cggtattaga aaaataggaa ggagctgacc gaacagggca 1019881 gctcctttca taaagctatg ccgtcggaat tcctccggtg atgccatata cctgagatgt 1019941 cacatagctt gaattctctg aagctagaaa tacataaaca tcggccaatt ccactggctg 1020001 cccagcgcga tttaatggag ctggcggcgt gccttgtccg aatttcggga tgttttccgt 1020061 cggctgtccg ccggaaattt gcagcggtgt ccaaattggt ccgggcgcaa ctgaatttac 1020121 tctgatgcct ttggaagcaa gctgttttcc cagtccgacg gtaaagccga taatggcgtt 1020181 tttcgttgct gcgtaatcta acagcatcgg gcttggatta tagccttcaa ctgaggtagt 1020241 tgtgataatt gaagctccct ccggcaaata cggaagcgcc gcttttacaa cccagtaaag 1020301 ggaaaagacg ttcacttcaa atgttttata gatttgttca gtaggcagat cttcgatgtt 1020361 ttcgaccgct tgctgtttgc ctgcaacgag cgctagcaca tcaagtccgc cgagttcgtg 1020421 atgcgactgt ttgactagat cttggcaaaa ggattcgtcg ctcaagtctc cggggatcag 1020481 cactgctttt cggccttctg cttcaatcag ctcttttacc tcttcagcat ctggctgttc 1020541 ctcgggcaag tagttaatag ccacatcggc accttctctg gcgtaagcaa ttgcggcagc 1020601 gcggccgata ccggaatcgc cgcccgtgac aagcgctttt cgacccgtta gtttacctga 1020661 tcctttgtag cttttttctc cgcaatcagg gacaggcttc atgttctttt gcaggcctgg 1020721 cggttcttga tattgttcgg gaaattcatc atgaaaaaat gcttttatag gattcgtaag 1020781 atttgaatca gacatcagca acgctccttt tctgtttggt gtacattcgt atgtgtaccc 1020841 ctgagcataa gcagaaaaac atgttttggc agtttgaata gtgaaggaaa aagaaaacaa 1020901 gaaaaaacaa agccttcttc catatttatc ttgtcaaata agactatatg aattatgata 1020961 aattcgagct ataaatcaac taaatattgg gtgttgggag agtgaatcgt catgaaaaaa 1021021 gcggcggcgg ttttgctgtc actcggtctc gttttcggtt tttcatacgg agctggccat 1021081 gtggcggaag ccaaaacaaa ggtgaaggtc tataagaact gcaaggagct aaacaaagta 1021141 tacaaaggcg gagtggcccg cacatcgaag gtgaaaaaca aaggcggaaa aacgaagtac 1021201 aagccttacg tttctaaggc actttacgat gccaataaaa acaaagaccg cgataaagat 1021261 cttatcgcct gtgaacggta aataagaaaa agcaatctgg tgtccagatt gcttttttta 1021321 tgcttaggcc gcctgatcgg ccgcagcgct tttcgccttc cttgtcataa ggctgactgc 1021381 catcatgacc gtgatattca aaagcagggc gacgatgccg acattcaagt cttttgcggc 1021441 ttgcggcaga gccggaaata aagtgccgat cgtcgtttcc gtcattgtaa tataagtaac 1021501 tgctccgaca cctgcaataa tgccggcgaa agctccttgc tttgtcacca tattatgctt 1021561 gagcaggctg aacaaaaggg cggggaatag ctgtgtgaca aggctgtagc ccatcaaaag 1021621 cagcgtaacg atggtattcc cgcctttgaa ggtaaaatac accgaaatca gcgcaatcac 1021681 cggcactaaa aacttagcaa gcgccgatac ttgctgttct gtcgtgcggg gcgcgattac 1021741 cttgtacaca ttttttgcaa acagtgtgga ggcggacatt aagatcatag accctggcac 1021801 aagtgctgtc agcagtccgg cagcaccgat aattccgaca aaccaagggt caaatgcttg 1021861 cagagacagt ctcaaaagcg acaaatcccc gtctgcgcca ttcagatctg gaacttgcag 1021921 gatagccgca aagccgacga aaaggacgaa gagcaggacc agctggtaca aaggcatgat 1021981 gatggcgttt ttacgaaaca cttttgggtt ttcggctgaa tacgaagcgg aaaacgtgtg 1022041 aggccacatg taaaaaccaa gcgctgtcaa gagtacggtt gaactgaacc aggccacact 1022101 ttgtcccgat tcggggagcg taagaaagcc aggctttgcc gtttcaatct gctgaaacat 1022161 gtcttgaaat ccgccgtagt aatgaattgg caaatacaca cctaaaaaca gaacgacaac 1022221 cagaatcatg atgtccttca caaccgatat ccaggcagac ccgtgaatgc ctgaaaccat 1022281 aacataaacc gtgatggaaa cagcgccgat ccagatggca gcggtcgggg tgattttgcc 1022341 gtacgaggtt tccgatacaa tcagcccgag gcctttcagc tgcagtacaa gatagggaat 1022401 gagtgcggcg atgccgacca gtgaaacgag aatgccaagc agcggactgt tgtatttttt 1022461 tgtgaaaaaa tcagactgcg acatcagttt atgctgtttc gcgtacgtcc aaactgctgg 1022521 aagaagccag taagaaagga tgtaggccag acatccgtag gcgatgatat aaaaggctgg 1022581 accgcctttt ccgtaggccc agccgctgcc gccgagaaac gtaaaagtag tataaatttc 1022641 gcctgccatc aaaaggaaga cgaaaacagt tccgaagccg cgccctccga ccgtccactg 1022701 ctccaggttc atgtcttttc ctttttgggc gcgtataccg agaaaaatac tcaagagcag 1022761 gacaccgaag atgatgatga gagctgcatt cattctgctt cctccttttt attttccttg 1022821 tcgaggacat acacaatcgc catcagcgca gaggtcaaaa gagcccacat cacaatatag 1022881 gcaagaataa acggcatgcc gaacacatag ggggtcacct tatttgcaaa agggatgccg 1022941 agtaagattc cgataaaggg taaagcggca agaacgtgaa tcagtttcat agaatcctcc 1023001 ttctatttag gattgaggtg tacaagccta agcgtactga aaatgatgtc gcagatatcg 1023061 cagcacatgt cattttttgg agtgaaaggc tgtggttcga attataaata aatttatttt 1023121 gtttgtatag tgtgaattgt ctgaaattaa tgctctgaat cgcccgaaga gggaacgggc 1023181 agtatgattc aaaaggctca gagtctgtct ggggcaaata gatagtatgt taataattcg 1023241 ctgacctgct cacggattcg cggattaaaa tagcgatggt tttcttcata accgtcgatg 1023301 acaaatgtat agagtgtaaa ggcctcatcg cgttccgtct cgcggattgc aatttttctt 1023361 ttcctcagtt cttttctgac ctccatcaaa tccttttgtg ctatttttaa tgattcgctg 1023421 ataagctgtt tataaggatg cttcaatttt aatgtgcttt cttcaattcc ggcgagatca 1023481 cggttaaaaa tcgtaatggc catgggcaaa aagagagccc gttcaattaa atcgtatatt 1023541 tcctcctgca gatttggcat attgactcct tctttctaag ggaacgtttg ttctatttgt 1023601 attctatatc ggctggtgaa atgtttcaag acagaaaaaa tcaccaaaac tttttagttt 1023661 tctgctgata atgtgtagaa taaggataga caaacccggt aaggagtata aatgttggag 1023721 cattttttat cctatttgac acaagaacat ttaactgaat tatttcaaag ctatagggct 1023781 ttcggtccgc tcattgctgt gctgctgcct ttaattgaag catttctccc gtttttgccg 1023841 ctgatcgtgt ttgtggtggc gaatacgaac tcgtttggct tgtgggaagg attcatccta 1023901 tcctgggcgg gatcaactgc tggttccatt ctcgtctttt tgattgtccg tcaatacgga 1023961 cagagaaaat tgcttggatt tatccgcagt catccgtctg tcagaaagct gatgttatgg 1024021 gtggaaagac acggcttcgg tcccatgttt cttctgcttt gttttccatt tacaccgtca 1024081 gccgcggtga atgttgttgc cggtttgtca aggatcggaa cgcggccgtt tattttggcg 1024141 gcagcctcgg ggaagcttgt catgattttt atgatcagct tcatcggata tgatctgcac 1024201 gcgctgatta cacagccgat tcgaacggtc atcgccgtat tggtgatcac tgtcttatgg 1024261 tatgtcggca aaaaggtgga gcggtatctg catgtaagag ccagtcagcg tgagcatgat 1024321 ggagggagac agtaacatga aaaaacggtt ttggtttctt gccggtgtag tgtccgttgt 1024381 tctcgccatt caggttaaaa atgctgtctt tattgattac aaggtagaag gcgtcagtat 1024441 gaacccgacc ttccaggaag gaaacgaatt gttggtcaat aaattttcgc atcgatttaa 1024501 aaccatccat cgttttgaca tcgtcctttt taaaggccct gatcataaag tgctgattaa 1024561 acgggtaatc ggcttgcccg gtgaaacgat caaatataaa gatgatcagc tgtatgtgaa 1024621 cggaaagcag gttgctgagc catttttgaa gcatttgaaa tctgtttctg ccggcagcca 1024681 tgtaacgggt gatttttctt tgaaagatgt gacgggaaca agcaaggtgc cgaaaggaaa 1024741 atattttgtc gttggagata atcgcatata cagcttcgac agccggcatt ttggtccgat 1024801 aagagaaaaa aatattgtcg gtgtgatttc tgatgccgaa taaaaagacg ctaattgaag 1024861 aggcgtcttt ttgtatgccg tttggaaaaa tgtgttgaag aaaaatttgt aaggagctat 1024921 aatcaaaatt gttacctgtg taacaaaatt tatatatttt tttgactgga gggccgtttt 1024981 tattggtttt tgttcgtttt tcatgaaaca aaaggagtgg tgaatgatga tgaaatatga 1025041 agcagtgatt ataggaggag ggccggttgg atttatgctg gcttctgagc ttgcaatagc 1025101 cggagtggga acatgtgtga ttgaacggct tgaaaaacct gttccgcatt ccaaggcgtt 1025161 gacgctgcac ccccgaacgc tggagcttct tgagatgaga gggattttag agcggttcgt 1025221 atccaaggga agcaagatac ctaccggaca tttttcaatg ctggataccc gtctggattt 1025281 ttcaggcttg gatacgagct gtccttacac gcttttgctc ccgcagtcca aaacagaaaa 1025341 gcttcttgaa gatcatgcac gaagcctggg aacagaggtg tttcggggtg ccgaggcgct 1025401 ggcggttacg caaaacgggg aagcggtcca aacaattttt aaggatcggg acggcagtgt 1025461 acggacgatc acaagcaagt ttgccgttgg ggcagatggc gccgggagta ccgtccggaa 1025521 acaggcgaaa attgagtttc cgggaacaga cagcactgtc accgctgcgc ttggggatgt 1025581 ggtgctcctt tctccgccgc cgtcaggtgt gctgtccctt tgcacaaaag agggcggtgt 1025641 tatgattgtt ccgttatctc cagaccgata ccgtgtcgtt gtgatcagcc cttatcgcac 1025701 acaaacgccg aaagatgtgc ctgtgactga ggaagagctg aaagctgacc tcctgcgaat 1025761 ttgcggaact gacttcggtt taaccgaccc ttcgtggatg tcgcggtttg ggaacgccgc 1025821 gcgccaagcg aaacggtatc gggacggcag aatctttctt gcgggtgatg ccgcgcatat 1025881 tcattttccg gcgggcgggc aaggactgaa tgtcggcctt caggatgcaa tgaacctcgg 1025941 gtggaaactg gcggcggcca tcaaaggctc tgcgccttct tggcttttgg acagctacca 1026001 tgatgagcgg catccggcag cggaagggct cctcagaaac acggaggcac agacaaagct 1026061 gatcgatttc actcaagcag gcctccattt gcgaagcatg atgtcggagc tgctggcctt 1026121 ccctgatgtg aatcgatatg tagcggggca aatttctgcg ctcgatgtca gatatgaagc 1026181 tgatcgtacc atgccgccga atcgtttgaa cggggcaagg ctccctgaca tgaagctgat 1026241 tctttccgac ggcaattcgg aacggctgta cagctttctc caaaacggga cattcgtttt 1026301 gctgtcattg aggcaggaag ctgatgatca tatcgaagta aaaggcttac gtacggtaac 1026361 cgcctcgctt gcagaaccga atgaaaagtt gcggaatgtg cataccatat tgattcgtcc 1026421 cgatggacat gtagcctggg cggtggatgc atcagcgccc gattgttccg aggtgattca 1026481 aaaagggatc agccgctggt tttccgtcac cagccgagta taattcaatt cgattgtttc 1026541 atctgtaaca aaacggtatg atagaagaaa caatcgaatg aaaaaggatg gaaaacccga 1026601 tgaacacaga tcatacgaaa cgcaatcttt ttgaattgta tgcggagctc attcatcagc 1026661 aggagaaatg ggaggggctt attaaagcct ttttatctga cgaattgagg aagctggatg 1026721 tagagcacgg gagtaaatct caattgacga tgacagaaat tcatgttcta tcctgtgtcg 1026781 gggacaatga accaattaat gtcacgtcga tagcagaaaa aatgaatacg acaaaagcga 1026841 ctgtatcacg catcagcaca aaattgctcg gcgcaggctt ccttcacaga acacagctca 1026901 gcgataataa aaaggaggtc tacttccgat tgacgcctgc tggaaaaaag ctgcacagtt 1026961 tgcacaaata ttatcatcag aaggctgaac agcgttttct gtcatttttt gaccgctata 1027021 ccgaggaaga gattcttttt gcggaacggc tgtttcggga tctggtgaca aaatggtatc 1027081 cgtcgtcaga agaaattgaa ggggggcttc ctagcatttt taaataaaaa acacgcactg 1027141 cggtgcgtgt ttttcgcttt gcggccgcct cgagaattct ttcatttcac cctctggcag 1027201 cactcacttc aaatctgatc cattaacaac gaaatatccg cttatatttc ctcatctcga 1027261 tggtttgcga attaaaagtt cttgaaccct tttttcaact aggcactact gccgctgatt 1027321 gagctctttt tgtctttttt ttcaccatga agatggtgaa gcaggcgata aaacggcggc 1027381 agcagggcaa taaccagaat gacgcgaatg acctgaaccg caacgacaaa ggtggaatca 1027441 gcatgtaagg taactgacgt cgtcgccatc tctgcaatcc cgccgggcgc aaatgccaga 1027501 acagaagtga tgagcgaaat tcctgtcagc tcggaaacga tcacggcgct caaaaacatt 1027561 gctgcgatta aaccgacgga cgagacaaac ccgacgatga taatacgggt gacgccggca 1027621 aacatgcttt tgtacatctt agagccgatc gttgccccga gaaatacttg tgatacatgg 1027681 ttagcttgtg acaaccacca tgccgtcatg tcgtgccctg tcaccgcagc tccgccaaca 1027741 tgtacaattg ctacaccgag catgctgccg agcagccatg gagctggaaa ttttaaaaat 1027801 ttcgcagctt tgcaagctcc ccaggcagcg agaataagaa tgacggtcca caaaacggga 1027861 gcgagcctaa aatctgtcgt tgcagaagaa atcgtctctg ctgcggcact tgcggtacga 1027921 tcttgttttg tatagatcag aatgactaaa aacggaatgg aaagcaccac gagcagcaca 1027981 cgcatcattt gaacgaggct gactatagcg gtattggcgc ctacttcctg tgcgatgctc 1028041 ggcatggcgg aaagtccgcc gggagcggtg ccgacaaagc tagtcatcat atccgttttg 1028101 ctgaaacgcc aaagcacata tcctgacagc atggccagca ggatagacaa tatcagcata 1028161 acgccgactg aaaaccaatg gtctttgaga acagagagaa cggataaatt cagcttttgg 1028221 cccaattcga tgccgaggat catctgcccg agggcgagcc atcgtcggtt aattcctttt 1028281 tggtctggtg ccatcatcag ccatgccggc cgtatcatgg cgaggcagca ggcgacaatc 1028341 agtgttccga tcatccatcc aattgatatt ccggttaatg aaagaataaa ccccccggct 1028401 gcactgattg cgataaacca tagatctttg aggagatttt cgtctttctt caatgtaaaa 1028461 cccttcttcc tttttcacgt aacactccaa ttgttcacgt agtgaatgta tttattacta 1028521 tagtatattt ttgttgataa agaaattatg aattattttc tataagcgat tcacttttct 1028581 tatgaccttg tgttcgagct tttctattgt gtaagtcaga gataaacccg ctgtcagcag 1028641 acacacggca agagcgtaaa aaatcacttc tccgccaaat gatgtcagga tcagcccgcc 1028701 tgccagcggt ccgattgagc gggatatatc ccaatgcaga ccatagacag cataaaaccg 1028761 gcccagcaaa tgaggcggcg ccaatttcga tatgaaggtc tggatgtggg ttagcccgat 1028821 gctttcacca accgtcatca ccgctgccgt cactaaaagc attgtcagag aggttgagca 1028881 tgcaaagccg gctgccgcaa gggagtagca aatataagta atgaagagga tcgttttcat 1028941 tgaaagcttt tcggtccctt tgacaagagg tacttggaga acacagctga ataaagcttt 1029001 tgctgctgaa tagatggtca gcatggacag ataatcagaa aacatgtttt tgctgaacag 1029061 cctgtatgtt gtttctgttt gtgcatataa catgctgatg gggagagaaa gcagcaaaag 1029121 aagcaggaca ggcctgtata ttgtaaagct cgcggacatt ttcggggtaa cagctgggtg 1029181 tagcggcttt gtctcaggca gtttcagtgc agcgatcaga aagtagataa acaatgctgc 1029241 agcatctaat gcgaatatcc acacggggtt atgattgtac agcagcatcc ccactagcgg 1029301 tcctgccgtc agacccgtcg aatagatcgc attgatgacc gcaaacactt ccgaacgtct 1029361 gctttccggc gtgctttcag cgatttgggc gcgggaagcg ggaatgtaca acgatcttcc 1029421 gatgccattc atgacataga gaatagcgaa aacatacgca tgctcagcaa atacaaaccc 1029481 tgtcattgcc gctgattgaa gaagcaatgc ggtcaaaatc gctgtgcgcc gcccaagccg 1029541 atccgtcacc cgtcctgcag cgagcgtcag gaaaatatca gcaaatggct gaaggctgat 1029601 gatcagcatt ggcatcatga tactgccgtt taattgttca tgcagataca gcaccataaa 1029661 aggtcccatc attgcacctg tcaggcttgt cagcaattcg ccgaaaaagc ggagccgaac 1029721 gggagcggta tatctcgatt ttatagagtg aaaactggtc aacatgtgat cgccgccttt 1029781 cgctgtttga tatagtagta gtgtatagaa ggggcggcgg cccaaaaagt gaagaaaaga 1029841 agagataaaa gttccccttt tgtcgggagg tgcggggatt gaagctgata gagcactacg 1029901 tggcgcttgt aaaaacaggc tgcgccgagt atgggcaaat gaacgaaatg acgctcactg 1029961 agattgccga ctgtttattt tgtacagaaa gaaatgcaaa gctcatttta cataagctgg 1030021 agaacagcaa ttggattatc cgggaaagcg gggcggggcg cggccgcaaa tctaaaatcg 1030081 cgtttcttcg gaggcctgag gaactgcttc ttcaaactgc aaaggaatat accatgtcag 1030141 gaaagcttaa aaaggcaaag gagctgcttc agcagtatca gtccgcgttt ccagggcttc 1030201 aaaacgaata taacatgtgg ctatcagagg tattcggatt tgtgacggag acaggcgaga 1030261 atggggcgaa ggatgtcctg cggctgttca tcacgcctga atctgtcagc agtttggatc 1030321 catgccaaat atttttgcgg tctgagggcc atttcgtcaa acagatattt gatacactct 1030381 tcacgtttga ttcggatatg caggagccga agcctcattt ggttcatgga tgggaagagg 1030441 tcggaaaaaa acaatggaga ttttttcttc gaaaaggtgt gttatttcat aatggacagc 1030501 cgctgacatc gcgggacgtt gcgtttacat ttcagcgctt tttggaactg gctgacaacc 1030561 cgtataaatg gcttctgcac ggagtgaaac aagtcttaga aaagggccct tattgtgtgg 1030621 agctcatact cgataagccg aatgcgcttt tgccgtatgc tctttgtgat gaacggctgt 1030681 ccatactgcc ggcagaacag ggcggcggga aaaatggaac agggcctttt cagatgaatc 1030741 agcaacatag cgggatgctt gtgcttgaag ccaatgagcg ctacttcaag ggacgcccct 1030801 atttggatcg cgttgagttt gtgttttctg agcaagccgg agagatgaac ggttttacca 1030861 ttcaagaaaa acaaacatgt cctgagcagc aaactgtctt tgatgagcgg catgttcagt 1030921 atttgtcgct taatctgaaa aagaaggggc ctcttcagca ccgaagcttt agaaaagcgc 1030981 tccggctgct gatttcctct gaacggctcg ttcgtgaagc gggagggcac cgaagaattc 1031041 cggttacgtc ctttttgcat ccgagtcctt ttgagtggga gggcgtttcg ccatctgaat 1031101 tgttgaaaaa aagcggatac gagggcgaaa caatcgtgct ttataccttt tcggaaacgg 1031161 atcatcgtga ggacgccgaa tggattcaaa atatttgcgc ccagcacggt atcaggctta 1031221 cacttcaatt ctgtgatgct gctgatctgc gacggccgga aatcgtgcag atggcggata 1031281 tcattcatga cagtgcgacg ttttatcaag acagcgagtt tggttttctg catttgctgc 1031341 tgtcggagaa cagtttcttg tatcagcatc tatctgaaaa gctgacacag atttgctcag 1031401 gaatgacaga gcggatgttt tccatgcctg accgctgttc gagaatcaac atcctgcgtg 1031461 acattgaccg gcagatgata caggagctga acgcgatccc gctgtatcaa aatgtgctcc 1031521 aggtgacatc aagtaaaaat gtaaaaggcc tggtgcttga tgaagaggga tggattgatt 1031581 tgtactccgt atggctgtcc aaataaaaag agggttcttt tttgaaccct cttttttacg 1031641 ctgccatgct gcggcattgt tcagcacagg tgaagcaggc tttcgcacat gcttggcaat 1031701 gatcatgatc gtgctttccg cattcagtgc cgcatgcttc acaaatatcg gcgcaaagtg 1031761 cacaaatttc tttcataaac gggctgtccg tttgcatggc tttgaccgcc agcgcgcaaa 1031821 tatccgcgca ttccctgtca agccggatgc atccgctgag atgatgctgc acgctttctt 1031881 ccaagcattt agtgaaacaa tgattgcaag ccttcatgca atcgatgcaa gcctcaatac 1031941 aagcctcaga atattgctcc atggttgatt ccccctgtat gacagtatat ggttttatgt 1032001 ttcacggctg catttgaaaa aaacagggga gtgtgttttt agctaagggg atatgtacat 1032061 ataccctgaa tgggtatatc taacgttcca tcagatagta taggaaccag acagcgtgat 1032121 tttgttcatc acgtgctgcg cgcgtaaaga cgcctttcgc ttttaagttt gacgtttcct 1032181 cggccgcacg caagtaaaag tcgacggttt cttgttcatc tttaaaagcg gcgtccagtc 1032241 ctcttgtgaa attgtccggg cattcttccg tttgtttcgg catgatgtgt ttgccggtaa 1032301 ttgaaccata cagtgtggaa aattcacgga ggtggcgaat ctcgtcacgc ctgatttctt 1032361 caatctgttt tctgacctca tcgctgtggg cgagttcggc aagcttgcgg tagcattgaa 1032421 tagcactgaa ttctccgttg atggccttct gcaaattccg aatcaaaaca ggatcttccc 1032481 ggtatggcac cggataggga tagtagctgt aatgcaaggg gattcaactc cattcttagg 1032541 aattgggctt ctgtaaaagt atatgttggg cagggagaga tgtgcggaga taatcagctt 1032601 tttatatgtg aaaaggccgt ttttaccaat agatcagatt ggtcattttc gtcaacattc 1032661 gataaaatat agagagataa aaagagaggg gtcttctaat ttgggagcag agtttttagt 1032721 aggcaggtcc gggagtggaa aaacgaagct gatcatcaac agcattcagg atgaattgcg 1032781 ccgggctcca ttcgggaagc cgatcatttt tctagtcccg gatcaaatga cgtttttaat 1032841 ggaatacgag cttgctaaaa cgccagatat gggcgggatg atacgcgctc aagtgttcag 1032901 tttttcacga ttggcctggc gcgtcctcca gcatacggga ggaatgagca ggccgtttct 1032961 gacgagcacc ggcgtacaaa tgctcctgcg gaagctcatt gaggagcata aacaggagtt 1033021 caaagtctat caaaaagcga gtgacaaaag cgggtttacc gcacaggttg agcggatgct 1033081 gacagagttt aagcgctatt gtctggaacc ggaggatatc cgccggatgg cggaaagcgg 1033141 aacggcttcc gagtatcgcg gagaacgtgt tttatctgaa aagctccatg acttatcaat 1033201 tctgtatcag caaatggaaa aaagcctcgc agatcaatat cttcactctg aggattattt 1033261 gacattgctg gcagagcata tcccgcttgc ggaagatata aaaggcgccc atatctatgt 1033321 ggatggcttt tatcagttta ccccgcagga attcagggtg ttggagcagc ttatggttca 1033381 tgcggagcat atcacgtttt cgctcacagc ggacaagccg tcatatgagc gggagccgca 1033441 tgaactggaa ttgttcagaa tgacggggaa aacctattac cgcctgcatc agaaggcgaa 1033501 ggaactgaat ttggacatta cgtataaaga gctgagcggg actgagcggc atacaaagac 1033561 gccggaattg gcgcatctag aggcacagta tgaagcgcgt ccggccattc catacgcaga 1033621 aaaacaagaa gcccttactg tgatgcaggc cgcaaacaga cgagctgagc tggaaggcat 1033681 tgctcgggaa attcacgccc tagtcagaga gaagggatat cgctataagg atgtagcaat 1033741 tcttgcgcgc cagccggaag actacaagga tatggtgaag gaagttttcg cagattacga 1033801 gattccttat ttcattgacg gaaaagcatc tatgctgaac catccgttaa ttgaatttat 1033861 ccggtcgagc cttgatgttc tgaaagggaa ttggcgttat gaagcggtgt ttcgctgcgt 1033921 gaaaaccgaa ctgctattcc cgctcaatga accgaaggcc aaagtgagag aacaggtcga 1033981 tcagctcgaa aattactgta tcgcctatgg tattaaaggc gaccgctgga caaagggcga 1034041 tcggttccaa tacaggcgtt ttgtgtcatt ggatgatgat tttgcgcaga ctgatcagga 1034101 aatcgaaatg gaaaacatgt tgaatgacac ccgcgattgg attgttccgc cgctttttca 1034161 gcttcaaaaa cgcatgaaaa aagcgaagac ggttcaagag aaggcggagg cgctctatcg 1034221 ttatttagaa gagacggatg tgccgctgaa gctggatcag gaaaggcagc gtgctgagga 1034281 tgacggcaga atcattgaag cgcagcagca tcagcaggcg tgggacgcag tcattcagct 1034341 gcttgaggag tttgttgaaa tgatgggaga tgatgagatt tctcttgatt tgtttcagca 1034401 aatgatagaa gccggcgcgg agtcgcttac attttctcta attccgcctg cgcttgacca 1034461 ggtgtttgtc ggcaatatgg atttgtccag aatgtatggc acctcctgca cctttgtgct 1034521 cggggcaaac gacggcgttc tgccggcacg ccctgatgaa aacggggtcc tgtcggatga 1034581 tgaccgggaa tggctgaaaa cgattggggt tgagctatcc tcaggcggac gagagcgttt 1034641 gcttgatgag cacttcctca tctacatggc gttttcaagt ccgtctgacc ggctttacgt 1034701 atcgtatccg attgctgatg cggaaggaaa aacgcttttg ccgtcgatga tcgttaagcg 1034761 gctggaagaa ctgtttccgc atcataagga gcgcctgtta acaaatgaac ctgaacaggt 1034821 cagcgatgag gaacagctga tgtatgttgt gaataaaagc gtggcacagt cctttaccgc 1034881 gagccagctc aggttatgga ctcgggaata cgacatcagc gacgtctggt ggagcacgta 1034941 caatgtgctg atgagtgagc aggacaggct gcaatcgaaa aagctgttct caagcctgtt 1035001 tttccggaat gaagtgaagc agcttgaacg cagcgtgtcg agacagctct atggtgaacg 1035061 tattcagggc agtgtatcga gaatggaaac ctttaacgca tgcccgtttt cccattttgc 1035121 gtcacacggg ctgcatttga aggaacggca attcttcaag cttgaagcac cggatatcgg 1035181 ccagctgttt cattccagct taaagctgat ttcggacagg ctgcgtgagc aaaagctgga 1035241 ttggcgcgat ttaacgaagg agcagtgcga gctgttttcc tatgatgcgg tagagcggct 1035301 ggcaccgaaa ctgcaaaagg aaattctgct cagctcaaac cggcattatt atgtgaagga 1035361 aaaactgcaa aaaattgtga cacgtgtgtc cggcatttta agcgagcatg cgaaagcgag 1035421 cggattcgta ccgatcgggc ttgaactggg ctttggagga aaagggccgc ttccgccgct 1035481 gacctttcaa ctgaaaaacg gctgtacgat ggaactcgtc gggcgaattg accgtgttga 1035541 taaggctgaa agctcaaaag gcctgctcct caggattgtc gattataaat caagcgacaa 1035601 aggccttgac ttagcggaag tatattacgg attggcactg caaatgctga cgtaccttga 1035661 tttatcgatt acacattcag ctgactggct cgggatgagg gcgacgcctg ccggagtgct 1035721 gtatttccat attcatgacc cgatgattca atctaatctc ccgcttgggc ttgacgagat 1035781 tgaacaggag atctttaaga aatttaaaat gaagggcttg ctcctcggtg atcaggaagt 1035841 ggttcgcctc atggatacaa cccttcaaga gggacgttca aatatcataa acgccggctt 1035901 gaaaaaagac ggctctctca gatcagactc agcagcagtc ggtgaaaagg aatttgatct 1035961 tttgacaaag catgtgcgcc gcaccttcca agaagcgggc gaacaaatca ccgacgggcg 1036021 cgtatccatt gagccgtaca aaatgaagaa caagacgccg tgcacatact gtgcgttcaa 1036081 atcagtatgc caatttgatg aatcactgga agaaaacgag tatcgcccat taaaggctga 1036141 aaaggacaag acaatacttg agtggataaa aaaggaggcg gatggcaatg aacattccta 1036201 aaccggcaga cagcacatgg acagatgacc aatggaatgc cattgtttca accggccagg 1036261 atattcttgt ggcagcggct gcgggctctg gtaaaaccgc tgtgctcgtt gaacgaatga 1036321 ttcggaaaat caccgcggag gaaaacccaa tagatgtaga ccgtcttctc gttgtgacat 1036381 ttacaaacgc ctcagcggca gagatgaagc accgaatcgc agaagccttg gaaaaagagc 1036441 ttgtacagcg ccccggctcg ctgcatatta gacgccagct gtctctttta aaccgggcca 1036501 gcatttcgac gctccattcc ttttgcctgc aagtgctgaa gaaatattac tacttgatcg 1036561 atcttgatcc gggctttcgg atagctgatc agacggaagg cgagctgatc ggggatgaag 1036621 tgcttgacga gctgtttgaa gacgaatacg caaagggcga aaaggcgttt tttgagcttg 1036681 ttgaccgcta tacgacagac cggcatgatc tggatctgca atttctcgtt aaacaggtgt 1036741 acgagtattc ccgatcccat cccaacccgg aggcgtggct ggaaagcttt gttcatttgt 1036801 atgatgtatc agaaaagagc gccatcgagg agctgccgtt ttatcaatat gtcaaagaag 1036861 atattgcaat ggtgcttaac ggggcgaagg aaaagctctt gcgcgcgctt gagctgacga 1036921 aagcgccggg cggcccggcg ccgcgtgctg acaattttct tgatgatctt gctcagattg 1036981 atgaactgat tcagcatcag gacgatttca gtgaactata taagcgggtg cccgccgtct 1037041 cttttaagcg tgccaaagca gtaaaagggg atgagttcga tccagcgctc cttgatgagg 1037101 cgacagattt gaggaacggc gcaaaaaaac tgcttgaaaa gctcaaaacc gactacttca 1037161 cgcgaagtcc tgaacagcac ttgaaaagcc tagccgagat gaagcctgtc attgaaacgc 1037221 tcgtacagct tgtcatcagc tatggaaaac gattcgaagc tgcgaaacag gaaaaatcaa 1037281 tcatcgattt ttcggatttg gagcattact gtttagcgat tttgacagct gagaatgaca 1037341 aaggtgaacg tgagccgagc gaggctgcaa ggttttatca ggaacagttt catgaggtgc 1037401 tcgttgacga atatcaggat accaacctcg tgcaggaatc gattctgcag ctcgtcacaa 1037461 gcggtccgga ggagactggt aacctgttta tggtaggaga tgtcaaacag tcgatttatc 1037521 gattcaggct tgcggagccg cttcttttcc tctctaaata caaacggttt acagagagcg 1037581 gagaaggcac ggggcggaaa atcgatttaa ataaaaattt ccgaagccgg gctgatattt 1037641 tagacagcac aaacttttta tttaaacagc tgatgggcgg caaaatcggt gaggtcgatt 1037701 atgacgagca ggctgagctg aagcttggtg cagcgtatcc ggacaatgac gagacggaaa 1037761 cagagctgct gctgatcgac aacgcagaag atacggatgc aagcgaggaa gcagaagagc 1037821 ttgaaacggt gcagtttgag gcaaaagcca tcgctaagga aattcgtaag ctgatttcat 1037881 cgccgtttaa ggtgtatgac ggaaaaaaga aaacacatcg caatattcaa taccgagata 1037941 tcgtgatttt gctccgttcg atgccgtggg ctccgcaaat catggaggag ctgagagcac 1038001 agggcatacc ggtttacgcc aatttaacgt caggctattt tgaagcggtc gaagtcgccg 1038061 tcgcgctttc tgtgctgaag gtgattgata atccgtatca ggatataccg cttgcctctg 1038121 tgctgcgctc accgattgtc ggagcagatg aaaacgagct gtctttgatc cggcttgaaa 1038181 ataaaaaagc gccgtactat gaggcgatga aagactacct ggctgctggt gaccggagcg 1038241 atgagcttta tcaaaagtta aatacgtttt acggacatct gcaaaaatgg cgcgcgtttt 1038301 cgaaaaacca ctcagtatct gagctgattt gggaagtgta ccgcgacacc aaatatatgg 1038361 attatgtcgg cggcatgccg ggcggaaaac agcgccaggc caatttgcgt gttctttatg 1038421 acagggcgcg tcaatatgaa tcaacggcat ttcgcggctt gttccgtttc ctgcggttta 1038481 tcgaacgcat gcaggagcgg ggcgatgatc ttggtacggc gagagcgctc agcgagcagg 1038541 aggatgttgt ccgcttaatg acgatccaca gcagcaaagg gctcgaattt ccagtcgtgt 1038601 ttgtagcagg tctcggccgg aatttcaaca tgatggattt gaacaaatcg tacctgctgg 1038661 ataaggagct cggatttggc acgaagtata ttcatccgca attacgcatc agctatccga 1038721 cacttccgct cattgcgatg aagaaaaaaa tgcgcaggga gctgctgtca gaggaattgc 1038781 gtgtgctcta tgttgcatta acgagagcga aggaaaagct gtttctgatt ggctcatgta 1038841 aggatcatca gaaacagctt gcaaaatggc aggcatccgc gtcccaaact gattggcttc 1038901 tgccggaatt tgaccgctat caggcgagaa cgtatctaga tttcattggg ccggctcttg 1038961 ccaggcacag agacttgggg gatttggctg gtgtgccagc acacgctgac atctcaggtc 1039021 acccggctcg ttttgccgtt caaatgatcc attcctatga tttgcttgat gatgatctgg 1039081 aagaaagaat ggaagaaaaa agcgagcgcc tagaagcgat ccgccgaggt gaaccagttc 1039141 ccggctcgtt tgcgtttgat gaaaaagccc gcgagcagct gagctggacc tacccgcatc 1039201 aagaagtgac gcaaattcgg acaaagcaat cagtttctga gatcaagaga aaaagagagt 1039261 acgaggatga atacagcggc agggcccctg taaaaccggc tgatggaagc attctgtaca 1039321 gacgtcccgc ttttatgatg aaaaaaggcc tgacagcggc agagaaaggg actgccatgc 1039381 atacggttat gcagcatatc ccgctgtcac atgtgccgtc gatagaagaa gctgagcaga 1039441 cggttcacag gctttatgaa aaagagcttc tcactgaaga acaaaaagac gctattgata 1039501 tagaagaaat cgtgcaattt ttccatacag aaatcggcgg acagctgatc ggtgctaagt 1039561 ggaaggaccg ggaaatacca ttcagcttag cgcttccggc caaggagatc tatcctgatg 1039621 cacacgaggc agatgagccg cttttagtgc agggtattat tgactgtctc tatgaaactg 1039681 aggacggatt atatctattg gattataagt cggaccggat tgagggcaaa ttccagcatg 1039741 gatttgaagg agcggccccg atcttgaaga aacgatatga aacgcaaatt cagctgtaca 1039801 cgaaggcagt ggagcaaatt gcaaaaacaa aggtaaaggg atgtgcgctt tatttctttg 1039861 acggagggca cattctgaca ttatagcgag atccataagc tccggaattt caggcggagc 1039921 gggtctcgtt ttctatataa aagagaggtg aaagcatttg cggattttac atacggctga 1039981 ctggcatctt ggaaaaacgc ttgaaggaag aagcaggctg agtgaacagg ccgatgtgct 1040041 ggatgaactg aatacgattg taaaggatga gcagatcgat gccattgtaa tggcggggga 1040101 tgcatttgac accgtaaacc cgccagcttt agccgagcag ctgttttatg aaagcctgtc 1040161 tgcgcttagc gacagaggaa agcgcccgat cgtcgtcatt gccggaaatc acgataatcc 1040221 tgaccgtttg tccgccgctt caccgctgac acatgaaaac ggcattcatt taatcggtta 1040281 tccgacaaca gagccgattc atattgaagt gccttcagca ggagagcttt tggcggttgg 1040341 agcgctggcg tacccatctg aagcgcggtt aaatgaagtg ctatccgata cgtttgatga 1040401 aaagctgctc cgtgatcact atgatgtgaa aatcaggcag gcgtttgagc atatgacaag 1040461 ccggttccgg accgatgcag tgaagattgc cgccagccat atttatgtgg caggcggaaa 1040521 ccaaaccgat tcagagcggc cgattgaagt cggcggtgca tacacggtgg ctgctgaaag 1040581 cctgccggca gatgccgctt acgttgcgct cggccatttg catcgcccgc aaacgatcaa 1040641 gcgggcgcgg acgcttgcgc gttattcagg atctccgctc gcctacagct tttctgaagc 1040701 gggctacgct aaatcagtga cgattgtgga cgcaaagcct ggggaagagg ccacttggca 1040761 agaggtgtta ttatcaagcg gcaagccact tgtgaagtgg aaagcggcaa atggattaag 1040821 tgaggtgtac agctggctgg atgaaggcag agatcagaat gcttggattg acttggaaat 1040881 ccgtgtcgcg gaccagctgt cacttgaaga gattcacagg ctgcggaagg cgcacccggg 1040941 ctttatccat atcaggccgg tttttgaaga acagaacaaa gaccgggaac ggatcgaggt 1041001 taaacatgtc tcaatcgagg accgctttaa gaaattttat gaaaaacaaa ctggcggtgc 1041061 ggtgccggat gaagaaatgg tgaagctgtt tttagagctt gcatcaggcg ttgaagagga 1041121 ggatgcgaaa tgaagccgat cgccttaagc attaaggggc tccacagctt tagagaggag 1041181 cagacgatag attttgaagg cctttccggt gccggtgttt tcggcatttt cggcccgaca 1041241 ggaagcggta aatcctctat actcgacgca atgacgcttg ctttatacgg aaaggtggaa 1041301 cgggcggcga ataatacgca cggaatctta aatcacgccg aagatacgct gtctgtgtcc 1041361 tttacctttg cgcttcagac gaatcaccaa atctcataca aagtcgagcg tgtgtttaag 1041421 agaacggatg aaatgaaggt aaaaacggca ctttgccgct tcatcgaaat caaggacgag 1041481 catacggtgc tggctgataa agccagcgaa gtgaataaaa gagtggagga gctcttaggg 1041541 ctgacgatcg acgattttac gagagcggtg gtgctgcccc aagggaaatt tgctgaattt 1041601 ctgtctttaa aaggggcaga gcgcaggcat atgcttcagc gtttatttaa tttggagcaa 1041661 tatggagaca ggcttgtgaa aaagctgaga cggcaggcgc aggaagccaa tgcgagaaaa 1041721 aatgaaatgc ttgctgaaca gtccggtctc ggtgaggcga gctcagaggc agtggagcag 1041781 gctgaaaagg ttctcgaaca agctgaagcc cggctggaag cgatgaggaa gaaccgtgat 1041841 caggcgaagg agcggtttac agagcatcag gagatatgga atgtccaaaa ggaaaaatcc 1041901 acttatgaag aagaggaaaa acgtctcgca gaagaacagc cgcatataga cagcatgcaa 1041961 aaacgcctgc tggaagcaga aacagcagca gcccttaagc cctatgcgga ccggtacgca 1042021 gaagcgatcc agcatgagga gcaagctgaa aaggaacaaa cgctagccca aaaggattta 1042081 gcagaccgga cagctttctt tcagcaaaaa catgaagagt atgaagcgtg gcgccagcat 1042141 aaaagcgaga aagagcctga gcttttagcc aaacaggaac agctttcacg cttgcaggaa 1042201 atcgaaatca aactgagtga ggccaagcaa gaggaagagc gcaaaaaggc tgacctccgg 1042261 cagaaagaag aggctcttca atctgtcatg aatgaattag agaccgtaac agaccgcctg 1042321 acacgagggc aaaacagaca gacagaattg aagcagcagc tcaaatccct gcaggtgaca 1042381 tccgatgagc gaaaaagctg ccagcaggcc gcagagatgg cattgcgcat cagacaaacc 1042441 gaggaacaaa tcaaaaaaga gaaaaaacga agtgaagaat tgaacctcgt gctgcagaag 1042501 atgaatgaag agaagaatac actcgttcaa aagacggaag cggaagaaaa caacatcatt 1042561 caggcatatg aggcagttca aactgtgtac catttggtgt gcgaaacgga acgctcatta 1042621 acacgtatga cggaagaggc tagaaagagt caacacacgc ttcacttaca gcgtgaaaaa 1042681 gcaagggtgg cactgctgac aaaagagtta gcccaaaagc tgactgccgg aaagccttgc 1042741 ccggtatgcg gttcaaccga tcatgatcca tctgcctcgg tacatgaaac gtatgaagcc 1042801 gacagccatc ttgaagagga catcaaacgg acagatgtgt tattgacgga agctgcagct 1042861 ctcagccagg agattctttc agccaaaatt atgcttgaag aacagtccgc gcgctttatt 1042921 gaacagtgtc cgtttttgca gacaattcaa gcacagaacc ttgaagcggc agcttccttc 1042981 gaacatcagc cggtgtatga agcatttgaa actgccaaat ttgaatggaa acgaatcaag 1043041 caggacattc tttctgttaa gacacgaatg gcacaaatga ttggcgccta tcaggagtct 1043101 ttaaaaaagg ccgagcagct taatgaaaaa atcggttttg aaaaaagaga agccgaccgt 1043161 attgaaagca tcatcagtga gcttcaatcc tcaatggaca gcagtctgaa catgtttaaa 1043221 gaagcatttc agaatcaatc tgtggacgaa gcagaaaaat ggcagcaagc cattgaagaa 1043281 aaggaccggg ctgcagaaga atgtgaaaaa cgaattgaga agagtatcgc gtttcttgct 1043341 gagcatgaag cacaaaagga aaaactgcgg gaatcgggac accggcttga gcgggaaaag 1043401 ctggagcttc attatgcggc tgaacgcatc aagagcgtga tagctgatta tgagcacgaa 1043461 ctcggagatt atgcaaaagg agattcgatt caaatcaaac tccgctctgt ccagcaggat 1043521 ctaaagctgt taaaggaaaa agaacaatct ttatatgaag aactgcaaag cgcccaaatg 1043581 aagctcaacc aagcgaaaag ccgcgcttct gcaagcgagc tcactcttca agaggcgaag 1043641 ggcagattgg aaaaagcaaa agctgcttgg cttgagcata caaaaaacac ctccattacc 1043701 cggactgagg aggttgaaca aagtctcatc ccagctgatg aacttgaaaa gatgaaaacc 1043761 ggcatagacc agtttatgga taaactgaag caaaatgctg caaacttaaa acgagtagca 1043821 gagatacttg ccggcagagc attatcagag agcgaatgga acgaaaccgt tgcagcatta 1043881 caagaagctg aggacgcatt tggcgctgct atagaggaaa aaggcgcggc cgcaaaagca 1043941 ctggctgtca ttcgcgacca tcataaacgg tttaatgaaa ttgaagctga actgaaaaaa 1044001 tggcagatgc atatcgacag gctggacaag ctgcaagctg tgtttaaagg caataccttc 1044061 gtcgaatttt tagctgagga gcagcttgaa agcgttgcga gggacgcctc agcaagactc 1044121 agtatgctga caagacagcg ctatgccatc gaagtagatt ctgagggcgg cttcgtgatg 1044181 cgggatgacg cgaatggagg cgtacgacgc ccggtttcca gtttgtctgg aggagagacc 1044241 ttcctcacct cgctttcact tgctcttgcg ctgtctgcgc agattcagct tcggggggaa 1044301 tacccgctgc agttcttttt cttagatgaa ggcttcggca cactggatca agatctgctt 1044361 gatacggttg taacggcctt ggaaaaactt cagtcagaca acctggctgt cggtgtcatc 1044421 agccatgtgc aggaactgcg tgcacggctt ccgaaaaagc tgatcgtcca tccggctgaa 1044481 ccgagcggcc gcggtacgcg ggtatcactt gagttgatgt aagggaggag cggatatggc 1044541 aaagcagatt gccggaatat gtgagctgtg cggccggagc gatgtccagc tgacagagca 1044601 tcatcttaca ccgaaagagg aaggcggaac gtttttgccg acagcgatgc tctgtattcc 1044661 ttgtcataaa cagattcatg ccttatatac caatcaagag ctcgctgtac gtttaaatgg 1044721 aatggctgaa ctcagaagcg atccagagct tgcccggttt gtcaaatgga tcagaaaaca 1044781 gccgcctgag aagctgatca aaactaagaa atcaaatgaa cgaaaaaaga aaaaatgact 1044841 aaaaagcagc cctctctttg cagagcggct gcttttatcc gtttccaacc atatccggaa 1044901 gcaaaagttg ttgttgaaaa gtaaccaaaa agcggtgctc gatgcaccgc ttttttattt 1044961 gcgcccccgt tggactgctg tgtacataat ggatcgcttt ccgtttgaag ccgtccattc 1045021 aaaacggtct cctgtccctt cgctgctgta gttgtagtga tgctgcatcg cgcattgtgc 1045081 ggtgtcattt gaaaagtgat aaaaggacac accctgcccc gccgaagtat tcgaaaagac 1045141 tcctttatta taagaaaaga cgcaatcgaa taccgataag ccgaagctgt gcaagtgctg 1045201 cagaaatgcg agaaaggttt cgtcgtcaag cgaatccaaa agcgccatga gcggccgctt 1045261 gactgatttc tcatagcgga tgcgttctcc gccggaaagg gagatgtttt ctgcaccgca 1045321 tgccaaaacc aacttgtcct gaaagccggc ttgctcccac tttcctttat gatggatcca 1045381 gattgggctg tgttggagac tgtccgccag cagtatatcg ccttcaccgt tttcgattaa 1045441 gcagatgccg tcttcaatga ggatggtgcc gtattcccac tttcgttcct ctgtatataa 1045501 caattgtttc cgtttcatcc atgctgtctc ctttttcttc attcctctct tttctttcca 1045561 attcaagcct gtcccataca actcttttat ggacaaatca actatctgcc tatagatgca 1045621 taaacttact aaggtgctga aagaaacgaa attgttacga aagaaacggg attggagctg 1045681 atgtcacatg tgtggaatta cgggttgggt cgattttaaa aagcagctcg tccaggaaaa 1045741 acaaacgatg gacagaatga cagacactct ttccaaacga gggcctgatg attcaaacgt 1045801 ttggggggag caccatgttt tattcggaca taaaagactt gcggttgttg atattgaagg 1045861 cggacgccag ccgatggcgt gtacctataa aggcgatacg tacaccatta tttacaatgg 1045921 cgagctttat aacacggaag atttgcgcaa agaattgcgg gcgcggggcc atcaattcga 1045981 gcgtacgtca gataccgagg tgcttctgca cagctacatc gagtggcagg aagactgtgt 1046041 cgaccatctc aatggcatat tcgctttcgc tgtgtgggat gaaaagcgta atctgttgtt 1046101 tgccgcgaga gaccgtctcg gtgtaaagcc gtttttttac acgaaggaag gctcttcatt 1046161 tctcttcggg tcggaaatca aagcaatcct cgcgcaccct gatataaaag cgcgagtgga 1046221 cagaacggga ctttctgaaa ttttcggtct tggaccgtcc agaaccccgg gcactggcat 1046281 atttaaaggc ataaaagaaa tccgcccggc tcacgcgctg acattttcca aagacggact 1046341 taatatttgg cgttattgga atgttgaaag cgaaaaacat acggacagtt ttgatgacac 1046401 ggttgccaat gtcagatcgt tatttcagga cgcggtgacg cggcagcttg tgtcggatgt 1046461 gcctgtttgc acattcctat caggcggtct ggactcaagc gcgattacag cgattgcggc 1046521 gggccatttt gaaaaggaag gaaaagcacc gcttcatact tattcgattg attacgaaga 1046581 gaacgataaa tattttcaag caagcgcttt tcagccgaat gatgacggac catggattga 1046641 aaaaatgaca gaggctttcg gcacaacgca ccacaaatgc gtcatcagcc aaaaagacct 1046701 cgttgatcat ttggaggaag ctgtactggt caaagacttg ccgggaatgg cagatgtcga 1046761 ctcatccctg ctgtggtttt gccgggaaat caaaaaggac tttgtcgtca gcctatcggg 1046821 agaatgcgcg gatgagattt tcggcgggta cccgtggttc catacggcag atgttgagtc 1046881 tggctttcca tggatgagat caacggagga gcggatcaag ctgctttctg actcatggca 1046941 gaaaaaattg aatctgaaag aatacgtaaa tgccaaatat gaagaaacct tggcagaaac 1047001 gccattatta gacggagaaa cgggtgtgga taaagcaaga agacagctgt tctatttaaa 1047061 tatgctttgg tttatgacga accttttgga tcggaaggat cgcatgagca tgggggcgag 1047121 cctggaagtg cgggtgccgt tcgccgatca ccggcttgtg gaatatgttt ggaatattcc 1047181 gtgggaaatg aaaatgcatg ataatcggga aaaaggcatt ttgcgcaaag cgcttgaggg 1047241 cattttgcct gatgacattt tgtatcgcaa aaaaagccca tatccgaaaa cacatcatcc 1047301 ggaatataca aaaggcgtca gcgagtggct gaaaacgatc agaagccaaa aggactccgt 1047361 gctccatacc ttactggaca gaaaacaatt agatcagctt ttagaaacgg aaggctcctc 1047421 cttcaaggtc ccgtggttcg ggcagctcat gaaggggcct cagctgatcg cccatcttgc 1047481 tcaaattcat acatggtttg aagcgtatcg cattgatatt gacgagaggt aggttcaata 1047541 caaatgtgat taaaagccag agatgtatag atttaaataa gaaggataga tgagcaggga 1047601 aatatatgct ctatctatcc ttttttgtac aacagcacta tcgaattgcc cccgcattcc 1047661 ttcaataaga atgaataggt tttaatgttc tgccgataaa actagctgat accgggctta 1047721 actttaattc cctagcccat acagaaagtt gaccaatatg gtgaatttcg tgagcgatga 1047781 tatggtgtaa tatttcatct cgcgtatata aaacacctgt ctcccaagga acgcttacaa 1047841 gttcatcttt tatttgatct gaatgtgttt gtaaaacatc aattatttca gttcggaatg 1047901 tatttgagag agatttcact ttattgagtg tttgataatc agcgaactga acagcgatat 1047961 cttcttttcc ttggatagca cgaatccaac tatattccac atcaataata tgaaaaaggg 1048021 tatataaaat attctctact ccgccaagac gatttttaag taattcttca gtggttagtt 1048081 gatgacacca agtaaaccat tgatctctaa cctgccagtt atattcaaaa aatttcatca 1048141 ctaaactcac tccaatacta tcatgtatca taacaattag cccttttttc cgtgattcct 1048201 ctattaatga agtgatgatt gagaaatgtt tacattctac ctgttgtatg gcattaaaaa 1048261 taataatgca tatctcgtcg atgatgctgt gcgtcttgtt acttttacaa agtaagaatc 1048321 ggcattttct tcatatacaa ttaggaaaaa acatactaga cttgaagaag cagtgataca 1048381 taggagtgag aaaatgaaag agataaaaga agcttaccag caatgcggac agattgttgg 1048441 cgaatacgcg ccagcctgtt tcaaagcatt atcatatctc ccgctaaagc aaagacaagc 1048501 ctcttgggca gtattgtcgt tttgccacac ggcggccagt gcagacgaaa aggtattgcc 1048561 cgcatttgaa gctaaagctg atcatgttta ccaaaggaca aataacggta aacaacatct 1048621 atggaaggct tttgatcatg cgtatcggac ctttacattg gaaagcgaac cttttcggga 1048681 gtttattgcc gcacaaaaag aagacgccaa gccgtatgat gaccttgatg aactgctcat 1048741 gtacgcatat cggacgggcg gtgctgccgg attgatgctg ctgccgatac tgacacgccg 1048801 aaaacaagat cagctcaaac aagcagccgt ctctctcggc ttggccatac agctggttcg 1048861 cttcttaagt gatcttggca cagatcagca aaaaaaccgc attccccgtc aggtaatgca 1048921 gcaattcggc tatacagagg ctgatctcca aaaaggcacc gtaaataaag cgttcacaat 1048981 gacgtgggag tatatcgctt ttgaagcaga agcctacctt gaagagtgtc aggatgcctt 1049041 gccgctattt ccgcagtatt ctcaaaaaac ggtgaaagcc gctcttcatt tgcaccgggc 1049101 tgttttagaa aaaatccggg cgaagcagca cgatgtattt caatatcact tcgctctcac 1049161 agagaccgaa gtgaagcaga ttctgtctga tatctaaaaa acacccggcc ttgattgagc 1049221 cgggtgttac gccatacctt tttgaatcca gatacgtgag cgccatcttc tgtacattaa 1049281 gattccccgg acccattcat ccgcgataaa agaaatccaa atgccggcaa gaccgaaacc 1049341 gaggtggatg ccgaaaagat aagcaagcgg gaggccaatg ccccacattg aaatcattgc 1049401 catgtaaacc gggaatttcg catcccccgc ggcccgcaga gagttaatga taatgacatt 1049461 aaacgagcgg cctggttcaa ggataatggt catggcaatc aataggcttg cagttgctat 1049521 aatgtcaggg ctttgtgtga agagtccgat caggtctttt gaaaagatcg tcatcaaaac 1049581 agaggtagcc gcagcaattc cgagtgccca atataagctc ttcatgcagc gctcataagc 1049641 ggcatcaaat tgtttgccgc cgatataacg gccgattaag atttgtgtac cctggctgat 1049701 cgcagtgccg aacagcaaaa taaacatcgt aatattttgc gtatacactt ttgttgtcaa 1049761 cgcctgcgcg cccatgatgg cgataaaata cgtgactatc atttgcgaca ggttgtatga 1049821 aagctgctct cccgcagaag gaatgccgat tttcagcagc ttgcgcaaat gctctttatg 1049881 catatgaaag acttttttca gcgacatctt cagctggatg cgtttgttga caatcacaat 1049941 catcgcgatt aatccgatga cgcgggcgat agatgtggac atggccacac cggcaacacc 1050001 gagaacagga aagccgaaca aaccgaaaat cacaacaaag tttccggcaa tgtttaaaat 1050061 gttcatgccg atagtgacaa acattgtatc ttttgtgtag ccgtagcttt ttaagatcgc 1050121 gctgaatgtc atgattaaag cctgaataaa ggacagacct ccgacaactt gtaaaaagac 1050181 tttcgcatca ggcatcagtg cgtctgataa tcccatcata tgaagcagag ggacagccgc 1050241 gaaaaagacg acggcgctga tggccaggct gatgaagaag ttggcgccga ttgacacata 1050301 agcgacttcc atggcttctt tcttttgccg tgagcctaga aattgtgaaa tgataacggt 1050361 cgttcctgtt gcgataaagc tgaacatcac gataattaaa tttaaaatct ggttgctgac 1050421 gccgactgct gccacgctgt tatccgagta ttggctgagc atcagtgtat cggcattacc 1050481 cataaacata tataatgaga cctcaataaa gatcggccaa gtaagcgaaa ataatgagaa 1050541 cgttttgtca gcgggttttt tcaaagcagt tgatttgaag acagcttgtt tcatcgtgtc 1050601 taaccccttt cgtaaataaa atcaacgttt taaagtgtac ctccatttcc ttataataaa 1050661 aagggataga aacgatactt cttgtaaaaa tccgacttaa aaaggaggat gattcaaatg 1050721 cctcgcatcc tgtttacagt cccgcctttt ccggtattta tcgcagctgg ggaaggggtt 1050781 tttaaaaaag gagaaaccca tgtgaaacgt gtattctccg tgtttgatct gatatatgtc 1050841 aaacagggaa cgttatatat aacggaaaat gaaacatcgt tttctgttga aggcggcgag 1050901 tacatcttgc tttctcccgg tcttgaacac tacgggacga agggcagtga tgaagcaacc 1050961 tcctactatt ggcttcactt cgatgaacat cgatatgaat ttacggcaaa gggaggcagc 1051021 aactggtctg agcttcagca ggaaaaaggg agcttcgaag agctggcccg ctacggattg 1051081 gccttgccga gaaaaggcaa ggtgcagcgc ccgcagttta tggcgcagca gtttgaaaag 1051141 ctgatcgatt actccgcgga aaactctgat ttgccgctca gaaagcaaat tttatttgag 1051201 gagctgatgc tgcatcttca aaaagaagcg ttccaaatac cgtctgcgaa agagcgggta 1051261 gcctgggagg cggcccggta tttacaggag cactataagg aaaagacgac aatcaaggat 1051321 ctgtcgctcg cccttcacta tcatcaggat tatgtgagcc gctgcatgca gcaggtgctc 1051381 ggcgtaactc cggcacaata cacgaaccgg gtgagaatga cggaagcgaa gcgtctttta 1051441 tcctctacaa atgataaaat gggcgttatt gcggaaacgg tcggaatgga agatccgaca 1051501 tacttttcaa aactctttaa gcagatagaa ggcatttcac caattgaata ccggaaaatt 1051561 gtcagccgga aagttcaata accagacgag ggatgaacat gaaaacaaca atttacgatg 1051621 tggcaaaggc ggcgggtgtt tcgatcacaa ctgtgtcccg tgtgataaac aatacgggga 1051681 gaatcagcga taaaacacgg cagaaggtca tgaatgtcat gaatgaaatg gcatacacgc 1051741 ccaatgtcca cgccgcggcg ttaacgggaa aacgaacgaa tatgatcgct ctcgtggcgc 1051801 ctgatatttc aaatccgttt tacggcgaac tggccaaaag cattgaggaa agagcggatg 1051861 agctcggttt tcaaatgttg atttgcagca ccgattacga tccgaaaaaa gaaacaaagt 1051921 atttttctgt gctgaaacag aaaaaggtgg atggcattat ttttgcaaca gggattgaaa 1051981 gccatgacag tatgtctgct ttggaggaaa tcgccagtga acaaattccg attgccatga 1052041 tttctcagga taagccgctt cttccgatgg atattgttgt gatagacgac gttcgtggcg 1052101 gatatgaggc tgccaagcat cttctgtcac tcggccacac gaacatcgcc tgcattatcg 1052161 gagacgggtc aacgacaggc gaaaaaaata gaatcaaagg cttccgtcag gcgatggagg 1052221 aagcgggcgt gcccattgat gaatcactta tcatccagac gcggttttcc ttggaaagcg 1052281 gcaaggaaga agcgggaaaa ttgctcgaca gaaatgctcc gactgctatt tttgccttca 1052341 acgacgtatt ggcttgtgcc gccatacaag ctgcgagaat aagaggcata aaagtgccgg 1052401 atgatctttc tatcattggt tttgataata cgatactcgc agaaatggcg gctccgcccc 1052461 tgacaaccgt agcccagccg ataaaagaga tggggcggag cgtcatcgaa ctgctggcag 1052521 aagcaataga gggaaaacga aaggcgaaac aaaaaatagt gctcccgcct gagcttgtag 1052581 tcagacattc tacatcaccg ctcaacacat gagcccgcta atgagcgggt tttttcatta 1052641 tgacagttga agccaaaaaa acatattgcg tgtaaaccaa aggcggtgta aaatataacc 1052701 atcttttgag aaagcgcttg cgcaaaatgg cagagcggat agaaccgctg tttttttagc 1052761 tgttaagaga aaacgctttc tcaaagcgag cccgaaatga gataaaggag aggatgggac 1052821 gtggaacatc aagtaagatg tgcagtattg ggattaggaa ggctcggtta ttatcatgcg 1052881 aaaaatctcg tcaccagtgt gccgggggca aagctggttt gtgtcggtga tccgttaaaa 1052941 gggagagcgg agcaggttgc cagagaactc ggtatcgaaa aatggtcaga ggacccgtat 1053001 gaagtgttag aagatcccgg cattgatgct gtcattatcg taacgccgac aagcacacat 1053061 ggtgatatga tcatcaaagc agccgagaac ggcaaacaga tctttgttga aaaaccgctg 1053121 acattaagcc ttgaggaatc aaaagcagct tctgaaaaag ttaaggagac aggtgtcatc 1053181 tgccaagtcg gctttatgag acggttcgat cccgcatacg cagatgccaa acggcggatc 1053241 gacgctggag aaatcggcaa acctatctat tataaaggct ttacgcgcga ccaaggcgcg 1053301 cctcccgcag aatttatcaa acacagcggt ggaattttta tcgactgttc catccatgac 1053361 tatgatattg cccgttattt gctaggggcg gaaatcactt ctgtttcagg acacggcagg 1053421 attctgaaca atccgtttat ggagcagtat ggcgatgtgg atcaggcgct gacgtatatt 1053481 gaatttgact cgggcgcagc gggggacgtc gaggcaagca gaacctctcc atacggacat 1053541 gacatccggg cggaggtgat cgggacagag ggcagtattt tcatagggac attgagacat 1053601 caacatgtga ccatcctatc ggctaaaggg agcagttttg atatcattcc agactttcaa 1053661 actcgttttc atgaagccta ctgcttggag cttcagcatt tcgccgagtg tgtccggaat 1053721 ggaaaaacac cgattgtgac tgatattgat gcgacgatca atttagaagt gggtatcgcc 1053781 gcaaccaatt cctttcgaaa cggcatgccg gtacagctag atgtgaagcg cgcttataca 1053841 ggtatgtaaa agctaagtat gttgcatttg aggctttccg caaaaaaagc aagggcattt 1053901 tagcccttgc tttctctttt ctcatataaa tagtacatat aatcagtagg tacgcctgaa 1053961 tggtccagct gtctcagcat ggcggttacg ttccctctgt ggtaagtgcc gtgattgacg 1054021 acatgcagga tggtgtctgc ataggttgat tccagtgtac ctagtttcgg atgctgcatt 1054081 gtgaaggtct gttctaagtc cgtctggcgg ctgaagaaat catgatactg tgactccagc 1054141 tcggcagcgt gctgtttaat cgctgccata ttaccttgcg cggactgtaa tttgcctgcg 1054201 ctgtctataa tctcttggta ggccactccc gaaagaacat tcagccaaat gtagtcagcc 1054261 ctgcacatat gaagcagcac gtcgctgaca gaaggaaata cgctctttac ttcttgatag 1054321 gcagtttcct ccggcaggtt ttcgatatgg gtaaatattt tcttgtttgc ccaagaatga 1054381 tagtcataaa actgttttgc atcagtcatc agcatgcccc cttttctaag aaattcgttt 1054441 ttttcatctg tttctccttc aattgcaaaa gagtgacacc ccaaaatatc ctgccgctgc 1054501 ccacattacc gctgcagagc atttgtttac gatcagcata agcctgccgc tcgtatctat 1054561 cgtctgaaac aaccggcccg ctattgcaag gctgatgaac caaatccaag acacagcgat 1054621 gcaggcggcc ataaagagcc atttctcaag ccccgaatat tgaagagagc tcgtgccgat 1054681 gacgccgatc gtgtccagaa tggcatgcgg gtttaaaaga gaaacagcgg ccgcaaacgc 1054741 agcttgcttt tttggtgtga acgtatgttt ctcattttgg cttgtgttcg gacggatgtt 1054801 ccaagtcacc cagcccatat aaagcaaaaa taaaaatccg ccggccatca tgactgtctc 1054861 aaacacaggc agctcctgca caatgacaga cacgcccgca acggctaata caattaacaa 1054921 ggtatcgcag actgaagcac tgatgacagc tgggagagcc cgccaaatat gcttttgcaa 1054981 cgcgccttgc tgaaaaataa acacattctg cactcccagc ggcaaaatta agccaaacgc 1055041 gagcacaatt ccgtgaatga ttgcattcat gctgaaaaag ctcctttcac attttttttc 1055101 aatcataaga gagattgtca ctaaagtctc cagccatttg gttgggttag gaaccagcca 1055161 aatgtataat gtgtaaaaaa ggggggcatg accttgtcgc aatggcagcc aagccgaaag 1055221 tcggatgttc cgctgcatcg gcagatcgaa caatatatga aagacaagat tcttcacgga 1055281 gagtgggctg tagggacgaa aatcccctca cagagaacgc tggccgacat gtttcaagtc 1055341 aaccgcagca cagtcacagc agccatagat gaactcacgt ctcaaggctt gttagaggga 1055401 agaaaaggcg gcggtacgaa ggttgtaaac agtacttgga gcgtgctgac ggctgagcct 1055461 ccgcttgatt ggagcgatta cgtccgttcg ggcattcatc gcgccaattc ttccatcatt 1055521 caagctatta atcagaacga accaagagcg gatatcatca gattaggaac tggagaactt 1055581 tcaccggatc ttgtgcctgc tgacacaatt ggacggatgt ttcagcaaat caatccgggc 1055641 gtcctgtctt taggatatga gcagccgaaa ggaaaccgtc agctgcggga ggcagtggcc 1055701 gaccatttaa aaggaaagaa gatccatgtg tcaccgtctg caattttaat tgtgtccggt 1055761 gcacttcagg cacttcagct catctcaatt ggacttttaa aacgagattc tgtcattttg 1055821 acggagaagc cgtcctacct tcaatccttg catgtatttc aatcagctgg gatgcggctt 1055881 cgcggcttgc cgatggatga tgaaggggtc aaagcggggc ttgtttcttc taatcgaaaa 1055941 caatatggag gacagctgct ttacacgatt ccgtcgtttc ataatccgac aggcacagtc 1056001 atgtcagagc agcgaaggaa agagatcatc agcctgtcaa aaaaagagca gatgcccatc 1056061 attgaggatg atgcgtacgg tgatttatgg tttgaagaaa aaccgccgca gccgttgaaa 1056121 gcaatggatc atgagggcaa tattctgtat ctgggcgcgt tttcaaaaac ggttagcccc 1056181 ggtctgcgaa tcggctggct tgccggtccg gagccggtta ttgaaaggct ggcggacatt 1056241 aaaatgcaga cagactacgg atcaagcggc ctgtcccagt gggcggctgc cgagtggctg 1056301 tcacagggat attatgaaga gcatctgact tgggtacgca ggaagcttaa agaaaggaga 1056361 gacgccgccg ttcattttct cgagcggtat gccggggaca ttgccacgtg gcggattccc 1056421 gcaggcggct tttatatttg ggtgacattt cacaaaaacc tgcctgtcag ccgtttcttt 1056481 tatgaattgc tgaaacggca ggtgcttgtg aatcccggct atatttatga cggtgaagac 1056541 cgaaacagca tcaggctgtc atattcctat gcatctcttg gagatttgga aactggcatt 1056601 aaagcggcag ctgaaacagc acgccgcctg atgatgtcct aggctttggt tatacgatga 1056661 cagctcccag tgccctggcg aaggcaatcg cgtgctcagg tgcgattttg cagcctttca 1056721 atttgtcgag ggagacatga agctgttcaa aacggcacgt gctgatgtcc atgttttgaa 1056781 gggacgtgcc ggtaaagctg gcgccttcca attcgcatcc gtcaaagtgt gtctgctgga 1056841 gcaccgtatc gctgcattca ctttgcataa gagcacagtg atcaaatcga acttgtttca 1056901 tatttgagta cgaaaatgag ctgaaatgtc cgtggcattc ctcgaatgaa acattccgca 1056961 gcgttgcttc cgccacattc attccaacca tttttgactg cttaactgaa gttctgtgaa 1057021 tgacagcccc gctgaaatcg gcgtttgata aatcgcattt ttcaaagatc acatcggtca 1057081 gttcaatatg ccgaaaagac acatcgataa agacgacatt tctgaatacc gttttttcaa 1057141 cacatagtct ttcgatatct tcgccgcaga tggtgcaatc ttcaaacaaa tgcatgctga 1057201 ttacatcatc ctgtgtcacg gcatcatgaa aatctgcggt ttgcaggttt tccggtatgt 1057261 tcggtttttg aattgcgatt ttattcatgt gatgacatcc tttgctgccc gaaaaacaga 1057321 ggcttccggg ttcaatttaa tagatcgtta aggaaattga tacatatagt aaatcgtgaa 1057381 gagccttttc ttggtacagc agcccgcttg ttttgtaagc ataaatggaa agcttcctat 1057441 acgtcaaggc gtttacaggc cgaaaaagcc aaagggaaca ggaggaatgc ggaatggggc 1057501 attacatcaa aaccgaggag catgtgacac tgtttgtaga ggatatcgga catggaaggc 1057561 cgatcatctt tttgcacggg tggccgttga atcataagat gtttgaatat caaatgaatg 1057621 agcttccgaa aaggggattt cgttttatcg gcgttgattt gcggggatat gggcaatctg 1057681 accgcccttg ggaaggctac gattatgaca cgatggccga tgatgtgaaa gcagtcattt 1057741 atacgctgca gcttgagaat gcgattcttg ccggtttttc aatgggcggc gcaattgcaa 1057801 tccgttatat ggcaaggcat gaaggagccg atgttgataa gctgatttta ctgtctgcgg 1057861 cggcccccgc gtttacaaaa cgcccgggtt atccgtacgg gatgaggaag caggatattg 1057921 acgatatgat tgaattgttc aaagctgatc ggcccaaaac actggctgat ttagggaaac 1057981 agttttttga gaaaaaagtg tctccagagc ttaggcagtg gtttctcaat ctgatgctgg 1058041 aggcttcctc ctacgggacg atccactcgg gcatcgcatt aagagacgaa gatctcagaa 1058101 aggaacttgc tgcaatcaag gtgccgacgc tgatcctgca cgggagaaag gatagaattg 1058161 cgccgtttga ttttgcgaaa gaattgaagc gcggcatcaa acagtcggaa ttggttccgt 1058221 ttgcaaacag cgggcacgga gcattttatg aggaaaaaga gaagatcaac agtttgattg 1058281 cgcagttctc caactcataa gaaaaaaccc gacattgatc gggtttttta tataattcct 1058341 ctgttttgca gtgcgttaat gatgagatca gctccatcgg aaatagaggt ctggtcagac 1058401 tcaatgatga aatcgggtga aagcggcgct tcatacggag aatcgatccc ggtgaaatgt 1058461 ttgatctctc cgtttcgcgc ttttttataa agcccttttg gatcgcgctg ttcacaaaca 1058521 tgcagcgggc acttcacata aatttcgaag aactcacctt taggaaagag cgctctaacc 1058581 atgtcccgat cctctctgaa tggagaaata aaagccgtta aaatcatttg cccgctgtcg 1058641 acaaacagct tcgccacttc tccgatccgg cggatgtttt caatcctgtc accagtctga 1058701 aatccaagat ctttgtttaa gccgtggcgg atattatcac cgtcaagcac gtagctctga 1058761 atgcccttgc ggtaaagctt ttcatcgaca gcattggcca gcaccgattt tccggagccg 1058821 gacaaacctg taaaccaaag gacgcagctt ttgtgtccgt ttaaggactg tctgtcagac 1058881 tttgagatgg cagcgggatg ccaaatgatg ttcggattgt gtgtcattgc aattccccgc 1058941 tgttttgctt gatggcaaca ggctgttggt gaagtccctt gatcagcacg gctgcgacct 1059001 caggccggct gaattcttta ggcggctttt tgccttggcg gagaagctct ctcacttttg 1059061 tgcctgataa gtggatgtgg tctctcgggc tgtgcggaca tgttttggag gtgcccatgt 1059121 ttccgcattt tcggcaataa aagctgtgct caaaaaacag cggcttgatg cccagctctt 1059181 cctctgtgaa tgattgaaaa atattttggg cgtcgtatgt tccatagtag ctgccgacac 1059241 ccgcgtgatc acggcctaca ataaaatggg tacagccgta attttttcgg acgagcgcat 1059301 ggaaaatcgc ttcccgcgga cctgcataac gcatggcggc agggaaaacc gataacatga 1059361 cacgatcctt tggataatag tgattaagca aagcctggta gctctccatt ctgatatcgc 1059421 tggggatatc gtctgacttt gtttctccga caagtgggtg aagcagcaga ccgtcgaccg 1059481 tttctaacgc tgttttttga atgtattcat gcgctctgtg aacagggttc ctggtttgaa 1059541 agccgacaat cgtcttccag ccgagttttt gaaaggccgc tcttgtttca gcgggcgttg 1059601 cataaaactg ttcgaaagat ttgtcaggca ggctgctgac cgtgataggc cctccgatat 1059661 agtaatccgg gcgcgccagc aattttttta cgcctgggtg ggcaggatcg tttgttttaa 1059721 aaacagacag tgcttcttgt gttttatcag gctggtatat atcggtgact gtgatcatgc 1059781 cgtaggtaac accgtctttc acaagcttga cgtgatctcc ggcagacagc tgtcttgctg 1059841 ttttttctcc gacaggcagc gtaatcggca ggctccacgg caagccgttt gccagcctca 1059901 tctctttcac aacggaatga taatcttttt ctcccaaaaa acctgttaac gggctgtagc 1059961 cgccgatcgc aataagctcc agatcactca gtgcaagctg atccagctct gcttggcacg 1060021 cgcacccttc aaaatggcat gcgggatcac agcggttgat taatacccct ccgtggggtt 1060081 cgtttccatt caacgtgttc aacctccatt tatacgtttc cttgttttct tttctgcact 1060141 taatgaaagt ttgacatcag cgccttaaca tcatttcgat tctcacatca agaacctgcc 1060201 atccgctatt cttgatgcag gccgcattct gttttctccc gtccggccca tcttccagcc 1060261 ctctcatcgt tcgggtccgg ggaaggcagt gtacacattt cacagcctat gctcggataa 1060321 tgttgatcgt gcagtttgtt ataaggcaaa ttgtgcaggc ggatgtacgt ccaaacgtca 1060381 tcccatgtcc agtggataag cgggcaaatt ttgatgagct caaacttctg gtccaggttt 1060441 acgtattgaa tatgctttct cgttggtgac tgatcccggc gcagtcctga aatccaagct 1060501 gtcatgccgg acaggtgctt tttgagcggt tcgattttcc gcaattggca gcagaggttc 1060561 gggttatgct tccacagctc tccgccgtac ttcgtcccct gttctgttaa gctcagctcg 1060621 ggttcgagca tctggattgc aaatcccgga tatcgttctt tgacggtctc gatcagctca 1060681 tatgtttcct gaaaatgaag cccggtatcc aaaaagatga tgtgtgcgtt tttgttgatt 1060741 tttgatatta agtcgagaag caccattcct tctgcgccaa agctgcaggc gtacacaatc 1060801 ttttctccgt acgttcggta agcccatttc aacacatcga gctcatcgat caattgatcc 1060861 gttatctgtt tggacagcat gtcgttccaa gtgtcatatg tgatggtttc gttcaatgtt 1060921 ttccccccgt ttgcatctgc tttttttatc tattgatcga gttataggca gactattcat 1060981 tttttgcata aaggttcagg ttttaggtgc cgcgcccgcc taaaatgagg tgcggaacca 1061041 ttaagagccc ggctgaatat gctttttagc aaaatggttt tatgcccaag gagaggtagt 1061101 atgccgattg ccatttatca ggggcatcat cattcgcttg ccccggcgga cattaacatc 1061161 gtcattgatg tcatcagagc ctttacggtc gcccattatg cgtttatcgg cggggcgaaa 1061221 gagattttgt tggtccggac agctgatgaa gcctttgcgc tgaaagacac ctatccggat 1061281 tatgttttga cgggagagga aaagggggtc ggtatcagcg gatttgattt agataattct 1061341 ccaaaacgta tggctgggca gaatatgacg gataaaagcc tgatccagaa aacaacaaac 1061401 ggcgtcacag cagcattggg ggcgctgaac gcaaagcatc tgttcgtaac tggattttcc 1061461 aatgccaaaa caacggcaca gcatgtgaaa aagctcgtcg caaacgattg tgtcataaac 1061521 atagtggctt cccatccatc cggtgatgac gatatggcat gtgcggagta tatcaaaggc 1061581 atcattgaag ggacaaatgt ggtaacggct gcggaggcga ttgaaagaat aaaaggctct 1061641 tctgttgcgg agaagttttt tgactgccgc cagccattgt ttgattcgga agacatcgtt 1061701 tactgtacaa aagaactgac gggcgatttc gtgatgaaag tgaaacaaga tggagaagtt 1061761 ccaacgatag agagggtcat aatatgaatg atttttcact agaattgcca gtgagaacaa 1061821 acaagccgag agaaaccggg cagtccattt taattgataa cggctatccc ttgcaatttt 1061881 tcaaagatgc gatagccgga gcgtccgact atattgattt tgtgaaattc ggctggggca 1061941 catcattact tacgaaagat cttgaagaaa aaatcagcac actgaaagaa catgacatta 1062001 catttttctt tggcggcaca ctgtttgaaa agtacgtaag ccagaaaaaa gtgaatgaat 1062061 ttcatcggta ctgcacctat ttcggctgtg aatatattga gatttcaaac ggtacgctcc 1062121 cgatgacaaa taaagagaaa gcggcttaca ttgccgattt ttctgatgaa tttcttgtgc 1062181 tcagtgaggt gggcagcaag gatgcggaat tagcaagccg gcaaagctct gaggaatggc 1062241 ttgaatatat cgttgaggat atggaagcgg gcgcggaaaa agtgattaca gaagccagag 1062301 aaagcggaac gggagggatc tgttccagca gcggcgatgt caggtttcaa attgttgacg 1062361 acatcatttc ctcggatatt gatatcaaca ggctgatttt tgaagcgcct aacaaaacgc 1062421 ttcagcaagg gtttattcaa aaaatcgggc cgaatgtgaa tcttgccaat attccatttc 1062481 atgatgccat cgcgttggaa acgctgcgtt tagggctaag atccgatacc ttttttctgt 1062541 aaaatagcgg ctgcggggct ctcgtcgtga agagagcctc tgcctattat tttttatggc 1062601 ggtacatagg cgtgagatag ggaagtgagg tcaggcggat gttgtagatg aagtcgatga 1062661 ctcttgtcga tatcacctgg catatgaggg cttgaatgac gatgccccag tcaataatag 1062721 acgcggtgac cataaaaatg atgcaattca tgatgagcag gatcgttcca ggattcccgc 1062781 cgcggtagat agaaatcatc agagcaaggg ctccgaatcc tccgttcgaa attttatatt 1062841 tgtataaaag tccgattccg agtcccaata acactgcgcc gcttgccaga tcaagccaca 1062901 ggttagatgt gatatcagga aaaactgcat caaagatcaa taccgagaca gaggtgacgg 1062961 tgatagaagc gagggtgccg gtgaatgttc tcatctccag ccattttaaa gcggtaaaaa 1063021 gcattgatac attcacagcc cacactgaaa atccgtgggg gatttgaaac agataatgca 1063081 atagcaccgc aatacctgct gcaccgcctg tcggaatatc atgcggaaat aaaaacaagg 1063141 acatgccgag tccttgtagt acgccgccta cgacaatcat aaacgtaagt tttgctttca 1063201 tcagcagttc agccattaag tcatttgctc ctttatgaaa agacttgtcc gctgttttca 1063261 ttttatgagg ctgtccatta tttatgtctc aaaataaaga aatggcccag cttaataggc 1063321 tgagccatcc cacttgtagc gattgacgat ctccatattg atctctgtgc caatgccttt 1063381 tcctttcggg atgtggacca ttccttttga aggctgcagg ctgacgagat ctgtaaaagg 1063441 attctccatg acgtcccact cgatcggttc aatgtgatcg ttcttcattt tagaccatgg 1063501 gggcagacag gcttgtgcaa ataaagcata gagccgtgag agcgatccgt catatgcatg 1063561 ggcggatgct ctgacgccga aataacgcgc gagctggagg cagtcccgaa actcatcaat 1063621 tccgttgaca tgcatgacat cgggctgaat gatatccaaa cagcgctgtg aaaggagagg 1063681 cacatattgc gccgggcctt tcatgttttc tccgccggca acaggaacag acaaacggct 1063741 tcgaagcata gcgtaatcct gcggctgatc aaagggcaaa ggctcctcaa gccagccaat 1063801 gttcgtccat tcggagaaat agcgctccca tttaaaagcc gcagcggcat cgtagctttg 1063861 gtttgcgtcc agaatcatcg taatggagct gcctgctgta tgctgcagcg cattgatgtg 1063921 ccggacatcc tccttgaatg aagtcccgcc aattttgact ttgatttgct caaaaccttt 1063981 tttcaactgg gcttcaacat tggagactga gcggctgatc cattgcgggg agtctgagta 1064041 cgattgaaaa gacgcgtaca caggaatctc ctctctgtat cgcccgcccc ataattcgca 1064101 aaccgaacaa tccgcagctt tggctgcaat ctctgtcagc gccatgctta cagcggaggc 1064161 cgcccgctgg tgccattttt gaatcgtgcg cactaatgac aggcggctgc cagcctgttt 1064221 tcctaataga aatgggatga tccgcttcgt aaaaccgaca tggagagcag ggagccaatc 1064281 aacgcattct ccccagccgt ctatcccgct ttcggtgata atcctgatga gataacaagt 1064341 ccgatatcgt ttaaacccat tggcatctcc gtatggcttt tctaatcgat gaaatagcgg 1064401 aaaggtttca atccgtacaa ttttcacact gggtgctacc tttcctcagc gggctggagc 1064461 cgattgccag ccattttagg gtcttctttt tcttttgttt cttcattgtt ttgcttcaca 1064521 tggatgagca tcatcacaag aatcccgaca acgagagtca atcccgcgat gcttaaaaac 1064581 atgccgggtc tggaccattg catcaggcgg ccgaaaatcg gaggaccgat cgctacccct 1064641 aagaaacgta cagagccgta cagcgaggtg acaaatcccc gtctttcttt gccgacagcc 1064701 ccggtaatga aactgttcac acaaggaagg acaagacctg agcctatact gctcagtaca 1064761 agaacactga taaaaaggac aagattttca atgaatgaca gtgccgcgta ggatacggtc 1064821 atgaacgcca atccaagtac gatcagcttt ttcattaacg attgcttttg cccgattttg 1064881 cttcctgttg tataggacgt cacacacata accaaaagcg ggatcgctaa aattaagcct 1064941 tttttcacgc cgtcggtgtc gtatgttttt tcaagaacat ctgagagata aaacaggatg 1065001 ccgaataaag taaacaaaca ggtcgcaccg gctaaataag cggtaaacag ccatctgcct 1065061 tcatgtttaa agacacttaa cagccctttt gcatattgtc cgattggtgg cggttctttt 1065121 tcctttttct tttctttaat aaaaatccaa gtcagtacga tcgaaatgat acaaaacaca 1065181 ggaaaggcaa aaaacgcgcc ataccagaca agcagggcga tcagcgagcc aatgatcggc 1065241 gatagcactt tccccatgcc gtttgaagct tcaacaaggc cgagcacctt gctctcctgg 1065301 gcgcctttaa acagatctcc cgtcagtgcc atggcaattg ggccggttcc ggctgccccg 1065361 attccctgta acgctcgtcc tgccatgacc caaggatagg cattgtcaaa aaaacctgcc 1065421 gcaaacccgg ctaacaaacc gccggcacca tacaaaatta agcagggaat aatgatgact 1065481 ttccttgaga atcggtctgc gagataaccg acaatcggaa tcgcaaatgc tgcaatcaag 1065541 gaaaatactg tgatcacgag actgacttga aattgtgata aatgaagttc agatttcatt 1065601 tttggcaaaa tcggaataag catcgagttt cctagggtta atattaaagg gattgaaccg 1065661 attgccacaa tcgtcattcc gttattttgt tttgatgatt ccatctcaga gcacactcct 1065721 tttcttctgc ttagaatgtc cctgatggct tcgtttattc agcgatcaga cagcaaaaaa 1065781 ccgaacagaa gatacctgtt cgggaaaaaa gagggttaac cgagagcctg tgaaatcaaa 1065841 gcatataagt gtccattttg aataggcgct tttttctgat agaacaaaat cggaggttca 1065901 tcatctttat gaaatcccat ttctatcagg ctgtcatgca gagacgtgtg ttcactcggt 1065961 atatcgattc gcatcggccc ttgtttgccg gccgccagcc ttgtaattat ctgtgctgca 1066021 acatctgatg atggagcgat gatagggccg aatttcaaat tggccggtgt ctgtacagaa 1066081 agtccgtagc caatgagctg tccgtcctga tttctggcga tgatacattc gcatgaagca 1066141 gaaataagct gctgcaaaag gtttgatcga tctccgccaa aggcagccag atccgccgcg 1066201 gttaagtcgt gaaagtcttg ttctctaaag gatgtcagtt cagcatcaag cttttttgta 1066261 taaggttgaa aactgtgaca gctgtacttt cgcactgaac ctgccgtatg aaaacctgct 1066321 ttttcataaa gcggcaaacc ttcttttgtg gcgcaaagcc tgatggcggt gttttcatcc 1066381 gtttgggtaa tacaggcgtt taccatacgc cggccaagac cgagccgttg atattccttg 1066441 tcaacgataa caaggccgat agaagtaaga cggccaaaca aaaacaagcc gatgcaggaa 1066501 ataatatcac cgctgacatt ttgataaccg aaaaagcgtc cctgctgaac aagcagtttc 1066561 agctcttgtt cgccataatc cggccacccg gcttgcccgc aaagccgcaa taagccggaa 1066621 acgtgttctt catgaagctt aatcagttca tctactacgt ccataagatc acctgcttgt 1066681 tctaagtgtt ttgtacatga caatatgatt gccaatgccg ggaatgtcaa atggttcgcc 1066741 aagttccttc cagccaagct tggcatagta gcccttgaca tggtgtcttg cgttgcacca 1066801 taccgcctga acgccgctct ccgccagttt gtgctccgcg tgtttgatca gcgtgcttcc 1066861 agctttttga tcgcgatatc cctcgagcgt tgccatgcct ctcagccgat acgcagaggc 1066921 ttccgttaat aaaggctgac tttgcgggga aaaagaagcg atgctgatca gcgttccatc 1066981 ataaaacacg ccgagatgaa aggagccttc tgcgtgatcc tctttatatt tgcattgttc 1067041 gatggattga tggggacgca gaatgcgatg ccggatttca tatgtatctt ccacggaaat 1067101 ggttttgact tcgagcataa tgttcctcct catgattgtt tttctatatc gtaacacgaa 1067161 tctcgttgaa aaagactgcc cgattcgatc aggcagtctt ttggaaatta atgcaaaaag 1067221 atattttggc gctgctcatc tttttgctga atatatgatg tgagctcagc ggttaagtca 1067281 gatctgagga aaggcgttat caagtagatg ccgttaaaca gctcgcatgc cgtatccagc 1067341 agggagcgtg caattgcaag gccttccgcc ttttgctttt ctttatcttc accggcatgg 1067401 gccatttttt cgcgaatcgt atcagacagc ttaatgccgg gaatttcatt atggatgaat 1067461 tcggcattcc ggctgcttgt cagcggcatg atgccgatat agatcggcgt cttcagatgt 1067521 tttgtttcgt tatggatatc gacaagctgc tgctcggaat agacaggctg agaaacaaaa 1067581 taatctgcgc cgcaatctat ttttttctca agccgtttta ccgctttatc cagatggcgg 1067641 acgttaggat taaatgcggc ggcaactgag aaattcgttt tcttgccgag cggttttcca 1067701 gacagagaca gaccttcatt gaattgtttg atcagcctga ttaaatcaaa agatgttaaa 1067761 tcatatacag acgtcgcccc aggaaaatcc ccgattttag aagggtcacc tgtaatagca 1067821 agcacgtcat tcagccctaa cgtatcaagg cccattaaat gtgactgtaa gccgataatg 1067881 ttacggtcac ggcacgtaat atggacaagg gaacgcatat cgagctgctg cttgacaagg 1067941 gcgccgcagg caacattgct gatccgcggg gtcgccaaag aattgtcggc gagtgtcagg 1068001 gcatcgattc ccgcttcttt taattcagca gcagcggaca gaaatttgtc aaagcttagt 1068061 tttttcggcg ggtccagctc tacgataata gagcgttttt tcgctgcgat ctcatccagg 1068121 ccgggctcgg ttcgctcgtg atgaacagaa atgaattctt tcgcccgggt tttgacttct 1068181 ttttccgtaa tcggagccag cccgccaacc gcttccgcca tcgccctgat gtgattcggc 1068241 gttgtgccgc agcagccgcc gataatccgc gcaccttgct tacggaattc tgacgcgctg 1068301 ttttgaaaat acgtgtcgtc tgtttcatag acgagccgtc cctcttcaag cgaaggaaga 1068361 ctgctgttcg gataaacgga taagaatacg tcatcaaaaa tcggcacttc gcttagcgct 1068421 tcaatcatgt gataagggcc gaggcggcag ttaatgccga caatatcagc tccgagatcc 1068481 gcaatcgagc gcaatgcgtc agaaagcggc gttccgtcct gcaatacgcc ttgctcgtgc 1068541 atggagacat tgagcataat cggaagatca gtctctttgc gcgcgatttt cagcacttca 1068601 cgggcttctt ccaaatcata atatgtttct aacagcaagc catccggctc ttcatgcagc 1068661 agcagataca gctgctcgcg gaagctgcgc ttaatttcgt caagactgta tgcgttttta 1068721 ttaaatgtgc gtatgccgcc catcgttcca agcacgtatg catcgcctgc tgaagcccgc 1068781 gcgatcttta cggcctcctg attcattttt ttgatgtcat cctcaagccc gtgtctggat 1068841 aatttaatat agttggctcc gtacgtattc gtttgaataa tgttggctcc cgcttcaacg 1068901 tacgctttat gtatgcgctg aatttcctcc ggctttgaaa tattgagctc ctcaaaacac 1068961 ctgtcaatgc cataggagta gaggagcgtc cccatggcgc cgtcaccgat taacacctgt 1069021 ctttgcaaat cttctaaaag tcccattgtc tgcctccttt attcacatca gcaaggaaaa 1069081 aagagaaata aaaaaagtcc tcttaagaag aagactttgt cagtgatttt gtctcttctt 1069141 atcttccaag ctgttcgagc ttgctggatt tagcaccttg gtcatggctg atcgccatta 1069201 caccggttgc tgaagcttcg tcgggccagt ccctctgctt ctcttgataa gaacggatat 1069261 gaaattttcg tgtcaggaag tgccaaaaga tatctggcgt ttttcccttt ctccaaattt 1069321 accgaaaata aagacaataa tcaataggaa tcagaaaatt tatctgaaat ttataaattg 1069381 aacgtcaatt ggcagatctg ctccccgtac agctgagata atctgctgca ggtcatcttt 1069441 gttttttccg gtgacacgca cttgatcatc ctgcacctga gactttactt tcagtccgga 1069501 gtttttgatg atcgtattga ttttttttgc gttgtccttg tcaatgcctt gaacaagctt 1069561 tgcacgctgg cgcaccgttc cgcctgacgc gttttcaacc ttgccgtaat caatgttttt 1069621 tgtcggtacg tttcgtttaa tcaatttgct gaccagcaca tctttcagct ggcttaattt 1069681 gaattcgtca tcggaaacga ggaccagctc ctctttatct aaagaaatgt cgcttttgct 1069741 gcctttaaag tcatatcggg tactgatttc cttcagtgcg atttggattg cgttttgcac 1069801 ttcaggcaat tccaccttgg atacaatatc aaatgaactt tcttttgcca tatgaaaacc 1069861 tccataacat ttaacttatg tgttgattat agtagaataa agagaaactt ccaacagaac 1069921 aaagaatcaa tttgtgatga ttggaaaaaa tgttaacaaa atccgcagag aataagcgga 1069981 acaggaagga cgatagcatg agaccagggc agcaattaac cttgagtata gatcaccaaa 1070041 ccgacttcgg ttacttttta accgatgggg aagatacgat tctcttacat aacagtgaaa 1070101 tgactgagga tatcgaggac agagacgaag tagaagtctt tatatacgta gaccagcagg 1070161 aaaggcttgc ggccacgatg aaaattccga tcatcagcgc ggatgaatat ggctgggttg 1070221 aagtggtgga taaagtggaa gatatgggcg ttttcgttga tgtcggttta tcgaaggacg 1070281 cactagtcgc aactgagcat ttgccgccgt acgaagatgt ctggccgcaa aaaggggaca 1070341 aactttactg tatgctgaag gtgacgaacc gggggcgcat gtttgcgaaa ccagcgccgg 1070401 aagatatcat cagcgaactg tttaccgacg cttcagaaga tctgatgaat aaagagctga 1070461 caggtacggt gtacaggctg atcgcatcgg gttcattcgt gatcacggat gacggtatcc 1070521 gctgttttat tcacccgtca gaaagaaaag aggagccaag actgggttca agagtcacag 1070581 gccgggtgat tcaagtgaaa gaagacggtt cagtcaactt gtcgctgctt ccgagaaaac 1070641 aggatgcaat gtcagttgat gctgagtgca ttctaacgta tatgagaatg agaaacggtg 1070701 ccatgccgta cagtgacaaa agccagcctg acgatatcag agaacgtttt aatatgagca 1070761 aagccgcctt taaacgcgcg ctgggccatt tgatgaaaaa cggaaaagtg tatcaggaaa 1070821 atggatggac atacgagaaa aaatagcatg aaaacggctc gcctgcagca gactgcggag 1070881 cgagccgttt ttttatgtct agtttaattc atcaaccagc ggccaactat atcatattaa 1070941 tttgccaaaa tcgtgttcaa atatttgttt taagggaaaa cataataaag aagaaagagc 1071001 ggaggaacat gccatggtac tagatcaaac aaaaaaatta ctcatcgtca tcatcggcgc 1071061 tttactcaat gctgccgggc tgaacttatt tttgatacct gcagatgtat atgccagcgg 1071121 atttacaggt gttgcccagc ttttatcaag cgtcgttgat caatatgccc ccttttacat 1071181 atcgacggga acgctcttgt tcctcttaaa cattccggtc ggtattttag gatggctgaa 1071241 ggtcggcaaa tcgtttacag tgtacagcat tttaagtgtc gcactcacta ctctgtttat 1071301 ggggatcctg ccggaaacaa gcctgtcaca tgacattttg ctgaacgcgg tgttcggcgg 1071361 cgtcatttcc gcagtcggta tcggcttaac attaaaatac ggagcttcga caggcgggct 1071421 tgatatcgtc gccatggtac ttgcaaagtg gaaggataaa cccgtcggca cgtatttctt 1071481 cattctgaac gggattatca tcttgacggc aggattattg caaggttggg agaaagcatt 1071541 atataccctg gttacactat atgtgacaac gagggtgatc gacgccattc acactcgcca 1071601 catgaagctt acggcaatga ttgtgacgaa aaaagcggac gaaatcaagg aagccattta 1071661 cggaaaaatg gtgcgcggca tcacaactgt tccggcaaaa ggagcattta cgaacgaaca 1071721 gaaagaaatg atgattatcg tcatcacgag gtatgaactg tacgatttag aaaagatcgt 1071781 caaagaagtt gatccaaaag catttacgaa catcgttcaa acgacaggga tttttggttt 1071841 ctttagaaaa gactgacgaa agcaggtgga agtcgtgaaa cggctgcttg tgatgctcct 1071901 ccccgtgctg cttttgatag gctgcgggaa agatgagcag acagaacccg ataaggaggt 1071961 atcaggcgga atggagaatc aagaggttgt tttatctatt gacgcaattc aggagcctga 1072021 acaaatcaag tttaacatgt cgctgaagaa ccaaagcgaa cgtgctattg agtttcaatt 1072081 cagcacaggg caaaaatttg aacttgtcgt gtatgattct gagcacaaag aaagataccg 1072141 ttattcgaaa gaaaaaatgt ttacgcaggc ttttcaaaac ctgacgcttg aatctggaga 1072201 aacatatgat ttctctgatg tgtggaagga agtccctgag cccggaacct atgaggtaaa 1072261 ggtgacattt aagggcaggg cggaaaatct caagcaggtt caggctgttc agcagtttga 1072321 agtcaaataa gaggctatgg cgagtcgcca tagccttttt ttattgcagt ttgtccagct 1072381 gattttgaaa ttgatgcaac tgttgacgtt ccgcatctgt cgaattggca tacgcagaag 1072441 atacagcatt tttggctctc agaatcgctt gctcctgatc gccttcctca aagccgtttg 1072501 tcaccatgac cgcctgttga acaaatgatt ttgcctgctg aaacagttca tttctcattt 1072561 aatattcata ctgcctttca gccgagtctc gtgccgcggc atgctggtga gcttcttcta 1072621 aagtagaccg atatggaaat cttgcggcgt gtagcccgat ggagtcttta ccctgctgaa 1072681 taaaccttct ggatttgctt cgtttaccca ttttgagact gcccccttcc atactttgac 1072741 gagatgagtc gtcttcaata gtatggtggg gtaaagtaag gtttatgagt gggaaaaatt 1072801 aatacggacc ttctttaaag tgagaaatat tctttcaaaa accttgccac gccgtcctct 1072861 tcatttgtgg ccgtagttcg gttggcaatc tgcttgaccg cgtcaattcc atttcccatt 1072921 gcaacgccgc agcctgcaaa ttcaagcatt tccaaatcgt tatcctcatc tccaaaagca 1072981 atgatccgct ccctcggcac gccgtaataa tcgctgattt tctgcaggcc gaccgcttta 1073041 ttcatgccgc ttttgataat ttcaatgaca tgccaaggag cggcccatct tctatggtcg 1073101 atcacctcgg catgcacatc cgataaatat gagcgtattg ccggcacatc ctcttccttt 1073161 gcatgtatga gtacggacgt cacatcttca ccgagatttt cccgcaagtc tccgaccgtt 1073221 acatttgttg tgttcatgtt aaaggcatct atcaggtgct catcatggta atgaaagtat 1073281 acgtcgtcaa tcacttcagc aagcacgtta tgtacgttgt agctctcgct gatatccacg 1073341 agctgtttga caacatcaag cggcagtgac gtatgatacc gtccccagct gtcgtcttgc 1073401 ggatgatgga caaatgctcc gttaaaattg acaattggcg ttgtcagctc catctgctgg 1073461 tagtacatgg aacttgaacg atacggacgg cctgttgaga tgcagacata atgcccgtca 1073521 tcttttaggc gctgtatcgt atgaagggtg ttttcagata tggttttatc atcctttaat 1073581 aatgttccat ctaaatctaa tgcgattaaa tagggttttg tctccatgaa aagctccttt 1073641 aaccttagat tttgcttgtt ttgccttact tacagtgtag ctttttacca tctttattgt 1073701 ctacatgtta cacttatgat tatggttatc ctaaggaggg gcacattgtg atacaaattg 1073761 agaatcaaac cgtttccggt attccgtttt tacatattgt aaaggaagag aacaggcacc 1073821 gcgctgttcc tctcgtgatc tttatacatg gttttacaag cgcgaaggaa cacaaccttc 1073881 atattgctta tctgcttgcg gagaagggtt ttagagccgt tctgccggag gctttgcacc 1073941 atggggaacg gggagaagaa atggctgttg aagagctggc ggggcatttt tgggatatcg 1074001 tcctcaacga gattgaagag atcggcgtac ttaaaaacca ttttgaaaaa gagggcctga 1074061 tagacggcgg ccgcatcggt ctcgcaggca cgtcaatggg cggcatcaca acgcttggcg 1074121 ctttgactgc atatgattgg ataaaagccg gcgtcagcct gatgggaagc ccgaattacg 1074181 tggagctgtt tcagcagcag attgaccata ttcaatctca gggcattgaa atcgatgtgc 1074241 cggaagagaa ggtacagcag ctgatgaaac gtctcgagtt gcgggatctc agccttcagc 1074301 cggagaaact gcaacagcgc ccgcttttat tttggcacgg cgcaaaagat aaagttgtgc 1074361 cttacgcgcc gacccggaaa ttttatgaca cgattaaatc ccattacagc gagcagccgg 1074421 aacgcctgca atttatcgga gatgaaaacg ctgaccataa agtcccgcgg gcagctgtgt 1074481 taaaaacgat tgaatggttt gaaacgtact tataaagcac taagttatta acaagagctg 1074541 aatttacgtt atactgtaga aaaaaggagt gagggaacgt ggaagaagca ttaaaagaaa 1074601 acatcatggg cgccctggaa caggttgtcg atcctgagct tggcgttgat atcgtgaacc 1074661 tcggcttggt atatgacgtt gatatggatg aagatggctt gacgcacatc accatgacgc 1074721 taacatcaat gggatgccct ttagcgccga ttatcgtgga tgaggtgaaa aaagcattag 1074781 cggaccttcc tgaagtgaaa gacacagagg ttcacattgt atggaatccg ccttggacta 1074841 gggataaaat gtccagatac gcaaaaattg cgcttggcat tcaataaaac aaaaaaggac 1074901 agcctgacat gtgaggctgt ccttttttac agctgaaagg agtgaaagga aatgatgtac 1074961 ctgctggcag ttttatgccc gccgcttgct gttttgtttt cgggaaaacc gtttcaggcc 1075021 ttgctgaatc tcatattgac ctgtatcttt tggctgccgg gcgcgattca cgcctgcttt 1075081 atcgtcgccg accgccgtgc cgaaaaacgg gcaagaagat aatttggaaa aatgaggacg 1075141 cagtcatggt ataatggtca taaaaacagc agggagagca ctatgaaaaa gaaattgctt 1075201 gcattcgcgc tttgtactgg cgcgtatgcg gccctgtttg cgtactctgt gaactcagag 1075261 caaaaaacag ccacaagcga gatgacggat gtcagccgcc tgatgcctgt aaaaataaag 1075321 cagacagtga aagggcagga agaggaaatg ctcattgaca cagtcaaaga ggcaaatcga 1075381 aaaaacataa aaatttcaat cgccggggcc cagcactcca tgggcggcca tacatattat 1075441 gaggacggca tcgttctcga catgacgggc tacaacaaaa tcctgtcact cgatcaagag 1075501 aagaaaacca tcagggtgca aagcggtgca acgtggaatg atatccagaa atacgtgaat 1075561 ccatacggac tcgcggtaaa agtcatgcag tcacaaaaca tttttacaat cggcggatct 1075621 ctcagcgcaa atgcacacgg acgtgatatt cgctacggct cgctaattga tacagtcaaa 1075681 tcattccggc ttttaaaagc tgacgggatg attatcactg tcactccaaa agatgatttg 1075741 tttacggcgg tcatcggagg gtacggcctt tttggcgtga ttcttgatgt aacgcttgag 1075801 ctgacagatg atgagctgta tgtcatgaag acagaaaaaa tgaattacag cacatactca 1075861 gactattttt caaagcatgt aaaaggaaat ccagatgtcc gaatgcatct ggcgcgaatt 1075921 tcaacagcga aaaaaggatt tctgaaagac atgtatgtca cgaattacgt attggctaat 1075981 catcaggatc agctgtcctc atacagcgaa cttaaagaag acgagtatac gggagccaca 1076041 aagtttgcac tcggcttgtc aagacggtat gaatggggga ggaattggct gtgggacaca 1076101 cagcaatcct atttcctgag ccagaacggc acagagattt cacgcaataa cgtcatgcgg 1076161 tccgaatcaa agtttcttga gtatgaaaac aatgacaaca cagatgtttt gcaagaatac 1076221 tttgtgcccg tgaaggagta tgggtcctat attgatgacc tgagacaaac gctgtcggac 1076281 gaagatctga acctgctgaa cattacgatc cgctacgtgc agaaaaatga aaaggccgac 1076341 ctttcctatg cgaaggacga tatgttttcg ctcgtactat taataaacga gggcttttca 1076401 aaagaagacc aggcagatac cgcccgaatc atcaggcgca tgacagacgt tgccatcaag 1076461 cacggcggca gctattatct gccttatatg acctaccaga caaaagcgca aatgagacag 1076521 gcatatccga aaagtgaagc gttttttcag aaaaaacgaa cctatgaccc ggatgagcgc 1076581 tttatgaatt acttttatca gaggtataaa taatggggaa aaacaaatta aaatggctga 1076641 cattatcaca aagcagcgtg tttttcgcaa gcagcttaat ctttccgttt tatattctgt 1076701 ttgtgaaaaa tatcggctca agctacacac agttcggttt ttcctacgga ttgttcgggt 1076761 tgagcggagc gcttatttac ccgctcctcg gacggctgtc tgaaaggttt gacagccgtt 1076821 attttctgct tctgaactcg tgggggatgg ctgttctgct tttatatgtc ccgcatatcg 1076881 gaagcgtcgt tcaagtgtat atcgtccaag tgctgttagg gctctttgga gcgatgcaaa 1076941 agcatggaga aaaagtgctg atcgctaatt ttacagacag tggagagcgt ggaaagaaga 1077001 tcgggaatta ccatttttgg acagctgtct tttcagcagc agccattatg ctcgggggct 1077061 ttctcgctga ctttttcaca gtgcaaatga ttttttatgc aagctctatt ctatattttt 1077121 tgagtggatt gatgatgatg aaaacaggct gacgcggtca gcctgttttt ttatgcggct 1077181 gaaatgcggc accgcatcaa cgtttttgtg ctggagtcgt gctgattttt tttgagcgga 1077241 attcccattg aacagaaaat ttataaatga ataaaaatat taaatatacg attgaattaa 1077301 tttttattca tgttataatg ttaaataatt tcacaaagac caagagggtg aacttgtttt 1077361 gaaaatagga attgtaggtg ctacaggata tggaggcacc gaacttgtca ggattctttc 1077421 gcatcatcct catgcagagg aatgcatact ttattcatcc agcggagaag ggaatgtcta 1077481 tagcgagggt tatcctcatc ttaccggctt agcggatcag cagctgaagc cgattgatat 1077541 gaatacgatc aaacacgaaa tagatatcat gtttctcgct gcgccgcccg gagtatcaag 1077601 tgaattgact ccaaagctgg cagacgcggg aattacggtt attgatctgt caggtgatct 1077661 gaggataaaa gaaccggctg aatatgaaaa atggtataaa cggacagcgg caccgaaggc 1077721 ggtgattcaa gaggcggtat acggtctggc agaactgaat caactgcaaa ttcaacaggc 1077781 gaaactcatt gccaatccag gctgttttcc aacagctgtt ttgcttggcc tcgcgccatt 1077841 ggctcaaaag aaactgctcg atgaatcttt cgttatcgtt gacgcgaaga ccggtgtttc 1077901 cggagcggga agaaaagcat ccatgggaac tcatttttct gagctgaacg acaattttaa 1077961 aatttataaa gtcaatgaac atcagcacac gccggaaatt gagcaggcgc tgaatgaatg 1078021 gcagccaggt ctcgggccca ttacattttc ggctcacttg gttccgatga caaggggcat 1078081 catggcgacg atgtatacca gattaacctg tgacctaacc gcagatgacc tgcatgattt 1078141 atattcggaa ttttaccaag attcatattt tgtgagagtg aggccaaaag gtcagtaccc 1078201 gcaaacgaaa gaagtgtacg gcagcaattt ctgtgatatc gccgtgaccc tcgatgagag 1078261 aacgaacaga gtcacgatcg tctcggtaat cgataattta atgaagggtg ccgccggtca 1078321 ggcagtgcaa aactttaatt tgatgaatgg ctggaatgaa gaaactggac tcaccatcac 1078381 gccaatttat ccatagaacg ggagagaatc gaaccatgat tcagttaagt gaagatcaaa 1078441 ttgtaaaagt aacaggtgat gtatcctcgc caaaagggtt tcaggcaaag ggtgtgcatt 1078501 gcggactgcg ctactcgaaa aaagacctcg gcgtcattat cagcgagaca ccggccgtga 1078561 gtgcagcagt ttatacccaa agccactttc aggctgctcc gatcaaagtg acacaagaca 1078621 gcttaaagca cggaccgaca ctgaaagccg tcatcgtcaa cagcgccatt gccaacgcct 1078681 gcacgggaga acagggctta aaggacgcat acacaatgcg ggagagcttt gcttcacagc 1078741 ttggcattga gccggagctt gtcgctgttt catcaacggg tgtcatcggc gagcatttag 1078801 acatggaaaa aatccacgcg gggatcgaac tgctgaaaga aacacctgcg ggatcaggcg 1078861 attttgagga agcgatttta acaactgata cggtgatcaa gcagacgtgc tatgaactgg 1078921 caatcggcgg caaaacagtc acgatcggcg gagcggccaa aggctctggg atgatacacc 1078981 cgaacatggc cacgatgctg ggatttgtga caactgacgc ggcaatcgaa gaaaaagcgc 1079041 tgcaaaaggc gcttcgggaa atcactgacg tttcatttaa ccaaatcaca gttgacggag 1079101 aaacatccac gaacgacatg gtattagtta tggcgaatgg ctgcgccgaa aacgagtgcc 1079161 tgacagaaga ccatccagac tggccggtct ttaaaaaagc gctcttgctc acttgtgagg 1079221 atctagctaa agagattgcc agagacggag aaggcgcgac aaaactaatt gaagcccaag 1079281 tacagggagc gaaaaacaat cttgatgcaa acgtcattgc caaaaagatt gtcggctcaa 1079341 atcttgtaaa aacggcagta tacggaacag atgccaactg ggggcggatc atcggagcca 1079401 tcggacactc cgcagcacag gtgacggcag aagaagtaga ggtttatctt ggcggccaat 1079461 gcctgtttaa gaataacgaa cctcagccat tctctgaatc tatcgccaag gaataccttg 1079521 aaggagatga aatcaccatt gtcatcaaga tggctgaagg ggacggaaac gggagagcgt 1079581 ggggctgtga cctgacctat gactatatca aaattaacgc gagctatcgc acgtaataaa 1079641 ggggagcgaa atgaagaaaa caatcgtttt taaatgcggg ggaagcgtca tccgtgagct 1079701 gtcggaggaa ttttatcaaa atctgaaaga gctgagggcg tcaggctgga agctggcaat 1079761 cgtacatggc gggggaccgg aaatcacaaa tatgctgaaa cggttaaata tcaagacaga 1079821 gttttcgggc ggacagagga aaacaacgaa gccggtgctg gaagtggcgg aaatggtttt 1079881 atccggttct gtcaataaat ttttcgttgc tgagcttgcc aaacacggac tgcgagccgc 1079941 gggcatttct ggtaaggatg gcggtctttt ggaggctgat tatctagatc cggaaacata 1080001 cggagaagtg ggagaaatca aaaaagtcga tgcgtccatg gtgaacgcgc tgatggaaaa 1080061 tggcatcatc cccgttattg cgccgctgtc tatgacaagc gactgcaaaa cgctgaatgt 1080121 aaatgctgat ctggctgctt cagcagtcgc cggagcgctt gaagccgata agctgatgtt 1080181 cgtcacggat gtcgatggaa tcatgaagga aaagcagcgt ctggacgtcc tgacccctaa 1080241 ggagattcag atgctgatca agcaggaagt gatcacagga gggatgatcc cgaaggtcaa 1080301 ttcagccttg tcagctttat cagatcaggt gtctgaagtc atgatcgtaa acggtaaagg 1080361 atcattcttc gcagaacaaa cctttcaagg gacaaaaatt gtcaaagcaa aggaggctgt 1080421 ttcatgagca gcttgtttca aacctacggc cgttgggata ttgacatcaa aaaagcaaag 1080481 ggaacgtacg ttgaggatca aaacggcaaa acgtaccttg atttcattca ggggattgcg 1080541 gtatcaaatc taggacactg ccatgaagcg gtgacagagg cagtcaaaaa acagcttgac 1080601 agcgtatggc acgtatccaa cctgtttcaa aacagtctcc aagagcaagc ggcgcagaag 1080661 ctggcagcgc atagtgcggg agatcttgtc tttttctgca acagcggcgc ggaggcgaat 1080721 gaaggtgcga taaagcttgc cagaaaagca actggaaaaa caaaaatcat cacttttctt 1080781 cagtcgttcc atggccgcac gtatgcaggg atggctgcga ccggacagga taaaatcaaa 1080841 acaggcttcg gcccgatgct tggaggcttt cactacctgc catacaatga tccttctgct 1080901 tttaaagctc ttggggagga aggcgatatt gccgcggtga tgcttgaaac agtgcaggga 1080961 gaaggaggag tcaatccggc gagtgctgaa tttttatcag ccgtacagtc gttttgcaag 1081021 gaaaagcaag cccttctcat tattgatgaa atccagaccg gcatcggacg gacgggaaaa 1081081 ggcttcgcat atgagcactt cggactctca ccggatatca tcacagtcgc caaaggattg 1081141 ggaaacggct ttccggtcgg cgctgtcatc ggaaagaaac agcttggaga agcgtttacc 1081201 cctggttctc acggaacgac tttcggagga aacatgctgg cgatggctgc tgtgaatgcc 1081261 acattgcaaa ttgtattcca gcctgacttt ttgcaagagg ctgctgacaa aggggcgttt 1081321 ttaaaagaac agcttgaggc agagctaaag agcccttttg ttaaacaaat ccgaggtaaa 1081381 ggattaatgc ttggaattga gtgtgatggc ccggttgctg acattattgc tgaattgcag 1081441 acattaggct tgcttgtatt gccggccggc ccgaacgtga ttcggctgct gccgccgctc 1081501 accgtgacta aggatgaaat agcagaagcc gtcagcaagc tgaaacaggc aatcgctcat 1081561 cattccgctg taaaccagtg attttttttc gatataaagg cataaaaatt catttttata 1081621 attaattatt catcaagagg tgggctgtta gatggaaggt tatttagtgt tagaagatgg 1081681 gacatcgttc agcggcgagc tggacggtca tgaaaactgc acgggagaag ctgttttttt 1081741 cacaggaatg acaggctacc aggaagtgct gacagatcca tcatataagg gacagattat 1081801 tgtatttacc tacccgctga ttggcaacta cggcataaat gaaaaggatt ttgaaagcaa 1081861 gaaaccgcaa gtaaaagccg cggttgtcta tgaggcgtgt gatcactttt ctcattatga 1081921 agcggtatac agcctcaagg agtatctaca gaaatggaat attccgctgt taacccatgt 1081981 tgatacgagg gctgtcgtga agaaaatccg ggcaaacggg acgatgggtg cgacagtcac 1082041 agcctctaaa gaaggagctg agattgccct tcaaccagag aatgtggcag agcaggcttc 1082101 cgcccaggaa atcagcacat tcggcgacgg gaataaacat atcgctctca ttgattttgg 1082161 ctataaaaag tcaatcgcat catcacttgt caaacgaggc tgcaaggtta ccgtggtgcc 1082221 ataccagcaa atggaggccg tatacaacat caaacccgat gggctatcga acggacctgg 1082281 agatccgaaa gccattcagc catatttagg aaagatcaaa agcatcatca gccgctttcc 1082341 gactctaggc atttgtctcg gacatcagct gatcgcgctc gcgtttggag ggaatacttt 1082401 taagctgcca ttcgggcaca ggggagctaa tcatccggtc atcgaccgta agacgaaacg 1082461 ggtctttatg acaagccaaa accacagcta tgtggttgat gaacagtcga ttaatgaaga 1082521 agagctcacc atcaggtttc atcatgtcaa tgatacgtca gttgaagggc ttgcccataa 1082581 aaaactgcct gtcatgagtg ttcaattcca cccggaagcc catcccggac ctgcggaaag 1082641 cgaatggatt tttgatgatt atctaaagaa tgtgatacca gcaaggagag aaatcgcgca 1082701 tgcctaaaga caccagtatt tcaagcatat tagtaattgg ctcaggcccg atcatcatcg 1082761 ggcaggcggc agaatttgat tattcaggca ctcaagggtg catcgcgctg aaggaggagg 1082821 gctaccgggt aattctcgtc aacagcaatc cggcgacaat tatgactgat gaagccttcg 1082881 ctgatgaaat ttattttgag cctctgacag cagaaagcct gacagccatc attaagaaag 1082941 aacggcctga tgggcttctt gccaatttag gcggtcagac cgcgttgaat ttagcggtgg 1083001 agcttgaaga aacgggtgtt ttaaaagagc acggcgtcaa actcctcggc acatccgttg 1083061 aaacgataca aaaaggagag gaccgggaaa aattccgttc gttaatgaat gaattaaaac 1083121 agcctgtgcc ggagagtgaa attgttgata acgaggccga tgccctccat tttgcggaat 1083181 ccatcggttt tcctgttatt atcagaccag cttacacatt aggcggaaag ggcggaggaa 1083241 tcgcccctga taaagaagcc tttacagcta tgattaagca ggcgctatta gcaagcccga 1083301 tcaatcaatg ccttgtcgaa aaaagcattg ccggctttaa agaaattgaa tatgaagtca 1083361 tgcgtgacag caataacaca tgcattaccg tctgcaatat ggaaaatatc gatccggtcg 1083421 gcgtgcatac aggtgactct atcgttgtgg cgccgtcaca aacattgaca gacgaagact 1083481 atcaaatgct gcggacagca agtctgacga tcatctcagc acttgatgtt gtaggcggct 1083541 gcaacattca attcgcgctt gatccattca gcaagcaata ttacgtcatt gaagtgaatc 1083601 cgcgtgtaag ccggtcatcg gctctcgcat ctaaagcgac cggttatccg attgcgaaga 1083661 tggccgcgaa actggcagtc ggatacactc ttgacgagct gaaaaatccg ctcacaggct 1083721 cgacttacgc aagctttgaa ccggcactgg attatgtgat cgtcaaattt ccgcgctggc 1083781 cgtttgataa attcaaaaac gcagaccgca agcttggcac aaaaatgaaa gccaccggtg 1083841 aagtgatggc gattgaacgg aatttagaag cggcgataca aaaggcagcc gcgtcgcttg 1083901 aattaaaaaa tatcgggaca caccttccag agctcagcgg gttgtcaatt gatacgctat 1083961 gggatttggc aatcactccg gatgaccgca gatttttcgt tgtcatggag ctgttgagcc 1084021 gcagcgtctc gattgatgac atccatgaaa aaacaaaaat tgatccgttt ttccttcata 1084081 cctttgacaa catcatcaaa ttggaaaacc gcctgatgga agcagggagc gatctctctt 1084141 ttgaattatt gaagaaagca aaggaaaagg gattctcaga cgcaacgatt gcctcgctga 1084201 tcagcaaaac agaagaagag gtgcgcgcgc ttcgcaagga gatgggcatt acgccttcct 1084261 ttaaaatcgt agatacatgc gcggcagagt ttgatgcgaa aacaaactat ttttactcca 1084321 catatttcgg agagaccgat ggagacatca gccgcaaaga gaaaaaacgc gcgctcatta 1084381 tcggatcagg cccgattcgg atcggccaag gcgttgaatt tgattacagt gctgttcacg 1084441 gtgtgctgac actgcaagag cttgggttcg aaaccatcat gattaacaat aacccggaaa 1084501 ctgtcagcac cgattatgaa attgcggacc gcctgtattt tgaaccgatg acaacggagc 1084561 atattgtaaa cgtggcggag caggaaaata ttgattttgc aattgtgcaa tttggcggtc 1084621 aaactgcaat caatgctgct gaagcgctcg aaaaagccgg cattactctt cttggcacat 1084681 catttcaaac gctcgacgtg ttagaggatc gggatcaatt ttatcagctt cttgacgagc 1084741 tgggattgaa gcacgcaaaa ggagaaattg cttatacaaa agaagaagcc gcttcaaaag 1084801 cgagtgagat cggctatccg gtgttaatcc gcccatctta cgttatcggc ggaatgggca 1084861 tgatcattgt tgactcgcaa gcccagcttt ctcagctgct gaatgatgag gacagcatgc 1084921 catacccgat tttaattgat cagtatgtgt ctggaaagga agtcgaaatt gatttgattt 1084981 ccgacggcga ggaagtcttt atcccgacat ataccgagca tattgaacgg gcaggtgtcc 1085041 attcagggga cagttttgcc attcttcccg gaccgtccat cacgagcggg ctgcagcagg 1085101 gcatgaaaga tgcggcacaa aaaattgccc gaaaactttc atttaaaggc atcatgaaca 1085161 ttcaatttgt gatcgacaat ggaaacatac tcgttcttga agtgaatccg agagcgagcc 1085221 gcacggttcc tgtcgtcagc aaagtaatgg gcgttccgat gattccgctc gccacacgtc 1085281 tgctggcggg agcgtcctta aaagatctaa atccggcagt tcaaaatcat catggagttg 1085341 ccgtgaagtt ccctgttttt tcttctcatg cgatccagga tgtggatgtc aagcttggac 1085401 cggaaatgaa atcaacggga gaaggcatgt gtgtcgcata tgattctaac agcgccttga 1085461 aaaaaatcta tacaagagtc tggagtcaaa aaggaagcat ttatttgcaa aacgttccgg 1085521 aagatgtgaa ggagttagca gaaaacgcag gttttacaat acatgaagga acatttgcct 1085581 catggatgga acaggaagga aactcgctcc acattaatct gagcggttct gaagaagcac 1085641 gcaaagaacg tttggaagcc atgacgcacg gcatccccgt ctttacagaa gaagaaactg 1085701 tgcgggcgtt tttacaaagc ggttcaggcc atccgcagcc tgtatctctc aaagacctct 1085761 ataaaaagga agtggcatca tgcacacagt gacgcaaacc agtttatacg gaaaagattt 1085821 attaacgtta aaggacctta gtgaagaaga tataaacgcc ttgctcgcag aagccggtga 1085881 gctgaaacaa aacaaaattc agcctatatt ccatggcaaa accttggcga tgatttttga 1085941 aaaatcatca acgcggaccc gtgtttcatt tgaagcgggc atggcgcagc tgggcgggag 1086001 cgccctcttt ctaagccaga aagatctgca gctggggcgc ggtgagactg tcgctgatac 1086061 ggcaaaagtg ctgtcaggct atgtggatgc catcatgatc cggacctttg aacatgaaaa 1086121 ggtggaggaa cttgccaaag aagctgacat tccggtgatc aatggactta ccgataaata 1086181 ccacccatgc caggcgctgg cggatctctt gacgattaag gagataaaag ggaagcttaa 1086241 aggcgtaaaa gtcgcgtaca tcggtgacgg aaataacgtg gcgcactcct tgatgatcgg 1086301 ctgcgcgaaa atgggctgtg atatctcgat cgcttcacca aagggatatg aagtgttaga 1086361 tgaagcagct gaagcggcaa agacatatgc acttcaatcc ggctcttctg tcacgctgac 1086421 agatgatccg attgaagctg taaaagacgc ggacgtgatt tattctgatg tgtttacaag 1086481 catggggcag gaagcggaag agcaagaacg tcttgctgtc tttgcgcctt atcaggtgaa 1086541 tgcggcgctg gtcagccatg ccaagcctga ctatacattt ttacattgtc tccctgcgca 1086601 tcgcgaggaa gaagtgactg cggagattat tgacgggccg aactctgcag tgttccagca 1086661 ggcggaaaac cgtcttcatg tgcaaaaagc actgctgaag gccattttat ataaagggga 1086721 atcatcaaaa aactgctgag ccaaactcag cagttttttt gatggcaaca tattcacagc 1086781 cgcttaggcg catactacag caaaaaggaa aaggaggaaa aacagtggga cagcagcacc 1086841 aattccggcc cggacagaaa gcgcctaata acggtgtcta cgtagaaatc ggcgagacag 1086901 ggagcatggt taaaaaccct caaaaggtcc atctgtcagc aggggaaatg ttccccgaaa 1086961 catcaaacca caaccggctg tggacctaca aaagaaagcc gtgaccacta aaaaacccaa 1087021 aacaataaat gttttgggtt tttggctttt taatgctggc ttgcattttt gttcataggc 1087081 atgatttctg ctaaaaccat gattaagaca tacagtacaa cagcaatgac agatgatgtt 1087141 ttgaaattat acgtaacgct gttcatgctt gcaaccaagt agcatgccat atgtgataaa 1087201 aggaacgtcc aaataaaggc aataatatat cgcacgtttc cacctcgtcc ttctcattct 1087261 attctaaaag ttatcatacc atacaaaaag cgaaggggga atccaatttt agcagaaagt 1087321 gaggtgacaa aagagtctga ttcgtcacac tttaatggta aaatataaaa cgtcaatcag 1087381 tataatagcc aaaaatgtaa aaggctagga ctttacctta ttcgtttctt ttctatttac 1087441 ataagatagc gtgagatgaa gtgtgaaagg aggcgggcaa gcgatgggaa taacggaaag 1087501 atactttcaa ctgggaacgg agcataatgt cattcatctg ccctatcgcc cgaacggctt 1087561 cggcatcttt atcttggggg acagaaccca ctttgtcgga catgattcaa gcttttggca 1087621 gcagcattat ggcagaaatc agcttctgag catgttgatg aatgaaggat acactctttt 1087681 taacagcaat ctgttcggaa ggcattgggg ggcggaaaaa gcagtcacct atgccaaaca 1087741 gctgatacat tctgtgctga agcaggaaat cctcaatccg aagattcata ttttagcaga 1087801 aggcatgggt gctctcgtgg ccgatgaact gcttcgtttt tccccggatc atatccgctc 1087861 agccgcaatg ttgaatcctt gtctcgatct tcaggcacat tatgaatcgg aaaaagaaaa 1087921 taaatttttc tataagcaat ttttgaaaga agtatcgaaa agctacggaa tttctgaaaa 1087981 agaagcggaa gcgattcgtt ataaaacaat tcaaagctac ccgagcggcg taccggttca 1088041 tatatggcag cgtatgaccg gagctccata tccctacagc gtacatgcgg aagttttcaa 1088101 ggaaaaacag caaaagcaag gctcaccggt cgacatgaca tttcatttat ttgagcatcc 1088161 aagcagaatt tatgcatcaa tttgcaaatt ctttcatagt catgaaaaag aattatagag 1088221 aatataatga caacagcctt ctcttttgcg gaggctgttt tgttttggga aatgaaaaac 1088281 cggaagggcg gcagatgcaa tggaatcaac gctgattgta ggtgcggacg aatttttcgg 1088341 cctttcatta tgtgagcgaa tgatggatga aggcatacat gttgacgttg ttctggcgga 1088401 aacagaagat aaaatgagac aaatgtactt agaagaaaga ctcatgtggc ttgggagaaa 1088461 tgaactcttt cgccagcttg aacacattgg agaccaaaat tatgatacaa tttgtatcca 1088521 gttcggaagt tttttgcctt tagaccaata tgattctcct tatattttag tatatgaaga 1088581 agaccgaaaa gaatgggata aacgtgaaaa aacaggctcg gaaaaaaccg tgatcctgcc 1088641 gaaaatgtac gggccatgga aagaagaaac agaggaagac ggctattaca caaacgacgt 1088701 ggctgacgag ttgctgagat tcctgttaga accaagccgt catagcaaag atcagctttt 1088761 tgaattgcaa gtcacagaga aaacctcaaa agaagaagca aaaacaaaaa ttatcgagtg 1088821 gaaaagacaa ttttcatcaa ttttcgacaa atattaagaa aaaccttcca tgtttcgagt 1088881 tttctagata caataaacgt ataaaaataa tacatgttat agcttgtcaa aaggagttga 1088941 acatgacttg atcacaaggc ttgtcatgat cttttctgtc ctccttttat tgagtggatg 1089001 tggacaaact ccgttcaaag gaaaaattga gaaggtcggc atgctctttc ctgatacgat 1089061 taatgacctc gtatggggca caaaagggta taaaggatta ctgaatatac aatccaaata 1089121 caatgtggac gtctattata aagaaggcgt taaaacagaa gaagatatca taaatgcgat 1089181 tgaggatttt cataagaggg gcgtcaatct gctctacggc catgggagtg aatatgctga 1089241 ggtgtttaac ttggtcggcg aagattatcc agatatggaa ttcgtcattt ccaatgcgaa 1089301 agcgaaagct gataatgtaa caagtgtcca ttttagcggg gaagcaatgg gcttttttgg 1089361 aggaatgact gctgcccata tgtcgaaaac gaatcaggtc ggtgtaattg cttcctttac 1089421 gtggcagcct gaggttgacg gttttatcaa aggggccaag tatgaaaatc cggatataga 1089481 ggtaaatacg aaatatacgg atcattggga tgatgataca acagcagtaa agctttatca 1089541 gaaaatgaag aacgaaggcg cggatgttgt gtatcccgcc ggagacgggt ataatgttcc 1089601 tgttattcag caaatcaaaa aagacggtct ttatgccata ggctacgtca cagatcaatc 1089661 ggatctgggc gagaataccg tattaaccag cacggtgcaa aatgtggaca aggcctatga 1089721 aatcattgct gaacaattta ataaaggcac ccttgagggc ggcgatcatt actacgacct 1089781 gaacacggga gtcgttgaga tgggaacatt cagcccgctc gtcgatcaag actttcagca 1089841 aagaatcgcc aagctgatca aaacatacaa caaaacaggc gagctgccaa aaaacgagta 1089901 atggagtgac gtcacatgca gcacgaaaaa tcacttgaat tcttgcaaat tgccatgaaa 1089961 tatctccctg aagcgaaaga acagcttgag aaatcaggca ttgagctctc aatggaggcc 1090021 atccagccgt ttatgaatct atttacaacg gtaatggcgg aagcttatga gcttggcaag 1090081 tctgacgcta aatctgaaac agaataagaa gaagccactt ttttgaaagt ggcttttcac 1090141 atgattttct ttttaatagc ggagagcatg ggcgcaagct cctttaaagc gggcttgatt 1090201 tgatcaagag agttcataat tgaaccgatt tggtccataa tatgcatgta attaatcgtc 1090261 tcttcgtcgt ttgtctgaga aacctgagaa acttcctctt gctgttcctc ctccttctct 1090321 tctgttggtt ttgctgcatc gccgaacatc attcttgaaa acacatccaa ctgcatacgc 1090381 ctcctttcca tataccatac tctatgagta agatgaactg atagtttaga cgaatatatt 1090441 gccatgtgaa aaaaaatagg atagaattag tacctgatac taataattga tcacaacctg 1090501 attgatcttc taaatttaag atataaagga gtcttcccta atgaaagctg gaatacttgg 1090561 tgttggacgt tacattcctg agaaggtttt aacaaatcat gatcttgaaa aaatggttga 1090621 aacttctgac gagtggattc gtacaagaac aggaatagaa gaaagaagaa tcgcagcaga 1090681 tgatgtgttt tcatcacata tggctgttgc agcagcgaaa aatgcgctgg aacaagctga 1090741 agtggctgct gaggatctgg atatgatctt ggttgcaact gttacacctg atcagtcatt 1090801 ccctacggtc tcttgtatga ttcaagaaca actcggcgcg aagaaagcgt gtgctatgga 1090861 tatcagcgcg gcttgtgcgg gcttcatgta cggggttgta accggtaaac aatttattga 1090921 atccggaacc tacaagcatg ttctagttgt tggtgtagag aagctctcaa gcattaccga 1090981 ctgggaagac cgcaatacag ccgttctgtt tggagacgga gcaggcgctg cggtagtcgg 1091041 gccagtcagt gatgacagag gaatcctttc atttgaacta ggagccgacg gcacaggcgg 1091101 tcagcacttg tatctgaatg aaaaacgaca tacaatcatg aatggacgag aagttttcaa 1091161 atttgcagtc cgccaaatgg gagaatcatg cgtaaatgtc attgaaaaag ccggactttc 1091221 aaaagaggat gtcgactttt tgattccgca tcaggcgaac atccgtatca tggaagctgc 1091281 tcgcgagcgt ttagagcttc ctgtcgaaaa gatgtctaaa actgttcata aatatggaaa 1091341 tacttctgcc gcatccattc cgatctctct tgtagaagaa ttggaagccg gtaaaatcaa 1091401 agacggcgat gtggtcgtta tggtagggtt cggcggagga ctaacatggg gcgccattgc 1091461 aatccgctgg ggccgataaa aaaaggtgag gtgcacacaa gatgactaaa aaaagagtag 1091521 ttgttacagg acttggagca ttatctccac ttggcaacga cgtcgataca agttggaata 1091581 acgcaatcaa cggtgtgtcc ggaatcggtc cgatcactcg tgttgacgct gaagaatatc 1091641 cggcaaaagt tgccgctgaa ttaaaagatt ttaatgttga agattatatg gataaaaaag 1091701 aagccagaaa aatggaccgc tttacacaat atgcggttgt ggctgcgaaa atggcggttg 1091761 aagatgcaga tcttaacatt accgatgaga tcgcgccgag agtcggtgtt tgggtaggct 1091821 ccggtatcgg aggacttgaa acactagagt ctcaatttga aatcttctta acaaaaggcc 1091881 caagacgggt aagcccgttt ttcgtgccaa tgatgattcc tgacatggcg acaggccaga 1091941 tttctattgc attaggagca aaaggggtga actcttgtac ggttacagca tgtgctacag 1092001 gaacgaactc catcggtgac gcgtttaagg ttattcagcg cggtgatgca gacgtgatgg 1092061 tcacaggcgg aacagaagcg ccgctgacaa gaatgtcatt cgccggcttt agtgccaaca 1092121 aagcgctgtc tactaatcca gatccgaaaa cagcgagccg cccgtttgat aaaaaccgtg 1092181 atggctttgt catgggggaa ggtgcaggga ttatcgttct tgaagaactt gagcatgccc 1092241 tggcccgcgg cgctaaaatt tacggagaaa ttgtcggcta cggctcaacc ggagacgctt 1092301 atcatatcac agcgccggcc caagacggtg aaggcggagc gagagcgatg caagaagcca 1092361 ttaaagatgc aggcattgca cctgaagaaa ttgattacat caatgctcac gggacaagca 1092421 cgtattacaa cgacaaatac gaaacaatgg cgattaagac cgtttttggc gagcatgcgc 1092481 ataaacttgc ggtaagctct acaaaatcga tgacaggcca cctcttagga gcagccggcg 1092541 gtattgaagc cattttctct atcctggcca ttaaagaagg cgtgattccg ccgacaatca 1092601 atattcaaac acctgacgaa gaatgtgatt tggattatgt gcctgatgaa gcccgcagac 1092661 aggaacttaa ttatgttctc agcaactcat taggattcgg cggacacaac gcaacattaa 1092721 tctttaaaaa atatcaatca taatcaagcc aaaccggctg cccttaaagg gtagccggtt 1092781 ttttttgtgt gcataggatt aaaagaggag gcgatcacat gagtgtagaa caaacatata 1092841 gctggctcag gaaggccggt tcaatagatg atttggcgca ttacattatc ccgctttttt 1092901 caggtgcgga gaaaaagaac tggaagggca ttctggggca tcttcagcat catgggatgt 1092961 ttaaaaacat aaaagagggt attcagacgg tttccaagct gaaggaaaaa ggtttttacg 1093021 gacatatcca aaaggaagaa cagtacctca aaaacaaatg gcaaggtcct gatgtaccaa 1093081 ttgttacgct gccggttgat gaacgaaaca ggagaatccg tttagaattc ggatcaaaat 1093141 caggactcgc ctttcaagac aaaatgttcc tttttctttc gtcagattta gattttgggt 1093201 cggtatctgc ccttatgacg catgagtatc atcacgtttg ccggttaggt catctgacaa 1093261 aagaggaaaa ggatgtcaca ttacttgata caatcatcat ggaagggctg gcggaatatg 1093321 ctgtttatga gaggttcggc cgaagtcaaa cggctgaatg gacgacttgg tatacaccgg 1093381 aacagcttca ggctttatat gaaaaaaaga ttgcgcccca tcgggatatc aaacgggata 1093441 atcgattatt tccccagctg ttattcggca aaggatatca gccaaaaatg cttggatacg 1093501 cagttggatt caatattgta aaaaaatatt taaccgccag caaggcaagc accgcagacg 1093561 ggctgtccat tcctgctgag acctttttgg atgcaatgct ttaaaaggat aaaataatgg 1093621 aatttcatta ataatattac atttatccta aaaaattctt gattttgcaa aatgattgta 1093681 ataatataca actataaaat ttttcgataa ttcaatatta tttattattt ctgaataaag 1093741 ggattgcttt ctcttgaaaa cgtttgacaa caagaggggg gaaaggggag ctagcatgag 1093801 cacactttta gaagtgaata atttaaagac ttattttttc aggaaaaagg agccgatccc 1093861 tgcggttgac ggagtcgatt ttcacatcag caaaggcgaa accgtcgcgc ttgtaggtga 1093921 atcgggctcc ggaaaaagca ttacttcttt atcaattatg ggcctcgtcc aaagctcagg 1093981 cggaaaaatc atggacggct ctattaaact cgaagacaaa gacctcacct cattcactga 1094041 aaacgattat tgcaaaatcc gcggtaacga agtatccatg atctttcagg aaccaatgac 1094101 ctcccttaat ccggtgttaa caatcggaga acaaattacc gaagtgctga tttaccataa 1094161 aaacatgaag aaaaaagaag cccgtcaacg agctgttgaa ctcttgcaga tggtcggttt 1094221 ctcccgggcg gagcaaatta tgaaggagta cccgcatcgg ctgtccggcg gtatgagaca 1094281 gagggtgatg attgccatcg cactgagctg taatcctaaa ctgctcattg ctgatgaacc 1094341 aacgacagcg ctggacgtga caatacaagc ccaggtgctg gagctcatga aagatctctg 1094401 tcagaagttc aatacatcga ttcttctcat cacacacgac ttaggtgtcg tgtctgaagc 1094461 tgccgataga gtgattgtca tgtactgcgg acaagtcgta gaaaacgcca ctgttgatga 1094521 cttattttta gaaccgcttc atccgtatac agaaggcctg cttacgtcaa ttcctgttat 1094581 agatggagag attgataaat taaatgcgat taaaggcagt gtgcctacac cggataatct 1094641 gccgccgggg tgccgttttg ccccaaggtg cccgaaagct atggataagt gctggacaaa 1094701 tcagccttcg cttttgacac acaaaagcgg aagaacggtg agatgctttt tatatgagga 1094761 agagggtgcc gaacaatcat gacagcagct aatcaagaaa caatcttaga gcttcgtgac 1094821 gtaaaaaaat actttccgat ccggtcaggc ctttttcaaa gaaaagtcgg tgatgtaaaa 1094881 gcggtggatg gtgtttcatt ttcgttaaaa aaaggagaaa cactcggaat cgttggagag 1094941 tcgggctgcg gaaaatcgac tgccggcaga acgatgatca gactgtacaa accgacagag 1095001 ggccaaattc tttttaaagg gcaggatatt tccaatctgt cagaggagaa gctgcggaag 1095061 agtgtccgca aaaatattca aatggttttc caagatccat ttgcttcgtt aaacccgaga 1095121 aagaccctgc gttccatcat aaaggagccg tttaatacgc acaacatgta taccatgcgt 1095181 gaacgaaacg aaaaagttga agagctgctt gcaagagtag ggcttcaccc gtcgtttgcc 1095241 ggccgttatc cccatgagtt ttcaggcggc cagcgtcagc ggatcggcat tgccagagca 1095301 ctcactttga atccagagct gatcattgca gatgagccgg tttccgcact tgatgtatcc 1095361 attcaggccc aagtgattaa cttgatggag gaattacagg aagaatttaa tcttacgtat 1095421 ctatttatct ctcatgatct gagtgtcgtc cgccatatca gcgacagagt cggagtaatg 1095481 tatcttggca aaatgatgga actgaccggc aagcatgagc tttatgacaa cccgcttcac 1095541 ccatataccc aagcgctttt atcctccgtt ccggttacaa gaaaaagagg ttctgtcaaa 1095601 cgtgaacgca ttgtcctgaa gggagaactg cctagtccgg ccaacccgcc aaaaggctgc 1095661 gtattccaca caagatgtcc tgttgcaaaa ccgatatgca aggaacaaat accagaattt 1095721 aaagaagctg ctcccagcca ctttgtggct tgtcaccttt atagctaatg ttgcccgcac 1095781 agctttgaga gggggtatgc acactacata aacaacagcc tagaagaacg aacatttcaa 1095841 gagggggaat atctaatgaa aagacggaaa accgcactga tgatgctaag tgtattgatg 1095901 gttctggcca tctttttatc agcctgctcg ggatcaaaat caagcaacag cagcgcgaaa 1095961 aaatcagcag gcaaaccgca gcaaggcggg gatttggttg ttggttcaat cggagaaccc 1096021 acacttttta actctctgta ttctaccgat gacgcaagta cggatattga aaatatgctg 1096081 tacagctttt taacgaaaac ggatgaaaaa ctaaatgtga aattgtcact cgctgaaagc 1096141 attaaagaat tagacggcgg ccttgcatat gatgtgaaaa ttaaaaaagg cgttaagttt 1096201 catgacggaa aagaactgac tgcagacgac gtcgtattta cgtacagtgt ccctttaagc 1096261 aaagattaca agggagaacg cggttcaaca tatgaaatgc tgaaatccgt agaaaaaaag 1096321 gcgattacga agtcttgttt aagctgaaat ataaagacgg taatttctac aacaatgcgt 1096381 tagacagcac agctattctg ccgaaacata ttctcggtaa tgttccgatt gctgatttag 1096441 aagaaaatga gtttaacaga aagaaaccaa tcggttcagg accatttaag tttaaggaat 1096501 ggaagcaggg ccaatatatt aagctcgaag cgaatgatga ttactttgaa ggaagaccgt 1096561 atttagatac tgtgacgtat aaagtcattc ctgacgcaaa tgctgccgtt gctcagctgc 1096621 aggcaggcga tattaatttc tttaatgtgc ccgccactga ctacaaaacg gctgaaaaat 1096681 tcaacaacct aaaaatcgtt actgatttgg cattaagtta tgtgtacatc gggtggaatg 1096741 aaaaaaatga attattcaag gataaaaagg ttcgtcaagc gctaacaacc gctcttgacc 1096801 gcgagtcaat cgtcagccaa gtattagatg gagacggcga ggtagcttac attccggaaa 1096861 gccctttatc ttggaactat cctaaagata tagatgttcc gaaatttgag tacaacgaga 1096921 aaaaagcgaa acagatgctt gcagaagccg gctggaaaga tacgaacggt gacggcattc 1096981 tggataaaga cggaaagaaa ttctcgttta cccttaaaac gaaccaagga aacaaagtcc 1097041 gtgaagacat cgctgtcgtc gttcaggaac agctgaaaaa aatcggcatt gaagtgaaaa 1097101 cccagatcgt tgaatggagc gctctcgttg aacaaatgaa tcctccgaat tgggattttg 1097161 atgcaatggt catgggatgg agtttatcca cattcccgga tcaatatgat attttccatt 1097221 caagccagat taaaaagggt ttgaactacg tttggtataa aaatgccgaa gcggataaac 1097281 tcatgaaaga tgcaaaatca atcagtgaca gaaagcagta ttcaaaagaa tatgagcaaa 1097341 tctatcaaaa aattgcggaa gatcagccgt atacgttctt gtattatcct aacaaccata 1097401 tggcaatgcc ggaaaatctt gaaggataca aatatcatcc gaaacgtgat ttgtataata 1097461 ttgaaaaatg gtggcttgca aaataaattt cccttaaagg ggagggagag cgttttctcc 1097521 ctcttctgtt tttaataagg aaagtaaagg gggacaagta tatggctgca tatattatca 1097581 gaagaacctt aatgtctatc ccgattttat tgggaattac gattttatca tttgttatca 1097641 tgaaagccgc gcccggagat ccgatgacat taatgatgga cccgaaaatc agccaggctg 1097701 acagagagca gtttattgaa aaatacggtc tgaatgatcc tcagtacgtt caatatttaa 1097761 agtggctagg caacatggtg cagggtgatt tcggaacgtc tattgtcaga aaaggaacgc 1097821 ctgtttcaga attgattatg gcaagactac ccaatacgct cctgctgatg ctggtttcaa 1097881 cgattttggc tcttatgatt tctattccgt tcggtgtcct gtcggcaaag cggccgtatt 1097941 caaaaatcga ctatggcatt acatttacct cgtttatagg cctggctatt ccaaactttt 1098001 ggtttggatt aattttgatt atggtgttat cggtaaatct cggctggttt ccaactgggg 1098061 gtgtcgagac actgaatacc gaattcaata tatttgaccg gattcatcat ttaattctgc 1098121 ctgcattcgt tctagctaca gctgacatgg ccggactgac gagatacacg agatccaata 1098181 tgcttgatgt attaaatcaa gattatattc gcacagcgag agcaaaagga tttaaagaga 1098241 acagagtgct atttaaacat ggattgagga atgcattatt acccgtcatt acaattttcg 1098301 gtttgatgat tccttcattt atcggcggat ctgtcgttgt cgaacaaatt ttcacttggc 1098361 cgggattagg aaagctgttt gtcgattcag cattccagcg cgattatccg gttatcatgg 1098421 caatgactgt gatctcggcg gttcttgtcg ttgtcggaaa cctcattgca gacatccttt 1098481 acgcgattgt tgatccgcgg atcgaatatt aaaaggaggg aaacagagat gtcagagctg 1098541 caaacaactc cctcgccgga gatcaggctg aaagaaaata tttcgaaaaa gccagaaaca 1098601 atgacaaaga ttttctggga aaaattctcg aaaaacaaac tggccatttt aggtgccgtt 1098661 attcttttta tcattattat gtctgctgtt ttcgcccctt taattgcacc ttatccccaa 1098721 gagcagcaaa gcctgcttga taaatataag gcgccgggcc ttgaacatct gatgggaacg 1098781 gataaatttg gacgtgatat tttcagccgg atcctatatg gagcgcgtgt ctctttattg 1098841 gttggatttg cgtccgtagt cggttcgatt ttgatcggaa cggttttagg agcattagcc 1098901 ggatatttca gaggaatagt ggatgctgtc attatgcgtg tagttgacat tgtgttatcc 1098961 attcctgata ttttcttgtt gatcacgctg gtcaccatct tcaagccggg tgtggacaaa 1099021 ttgattttaa ttttctgtct cacaggatgg accacaacag cacgattagt aaggggagaa 1099081 ttcttgtcgc tccgttcaag ggaatatgtt cttgctgcta aaacaattgg aacaaaaacg 1099141 cacaaaatta ttttttctca tatcctgccc aatgcgttag ggccgattat cgtgtcagct 1099201 acgctgaaag ttgggtctgt tattctagct gaatcggcgc taagctactt gggctttgga 1099261 atccagccgc caatcgctag ctgggggaac atgcttcaag acgcacagaa tttcacagta 1099321 atgattcaag catggtggta cccgttattt cccgggctat ttattttaat gaccgtttta 1099381 tgcttcaact ttgtcggtga tggcctgcgg gatgcgcttg acccgaaaaa tattaaataa 1099441 aaatgaatat catatctgtt ataaaatatc accaaatcag aaaaaagcag gtctccttta 1099501 gtcagaaaat atacaaagag atctgctttt tatgattctt acataaaccc agtgattcca 1099561 gatttcctca atctctttgg aataatttct ctatcccttg cctatactgt ggacaacagt 1099621 ttttataaaa gtgaggggtt agagatgtta tttcttcatg atgtgtgggt caattggttt 1099681 gaaggggaag aaaatggcta caatgtatgc cactttcacg aatggcgcaa ggaagatacg 1099741 gttgagcttt tggatcaggt gccgctgtta agggtgccgt cagtactgtt tcattacata 1099801 gaaaacgatt tgtcagagct tccgaaaggt ttgcttgaag acgtacatca gaaatcgtac 1099861 attcgaaaaa atcatgagcg gacaaagctt gagtattgtt ttgtcgtaac agacggaatc 1099921 ggcattttag ctgttgacac gatcggctac acgatccctg tcagaaaaag ccgtctaatc 1099981 ccaagacagg agcagctcgt ttatgaaatg gtaaaagatg tagagcctga aacatatgaa 1100041 tttgagccaa agaagctgga atcctccaag gaatatcaca tcttatcatt agcaccagaa 1100101 catgtcagag gactgacaag aaaagaacgg caaattaagc agctgatgtt tatggcgctt 1100161 gaccaattaa aagggctgaa aaaccgagcg gaaattggct actggtacac agagtggaat 1100221 ccgcatatgt atgaacaaat caaaaggatg agctttgaag agatttggga catgctgtat 1100281 aacgaaacaa ttgaaggctg gtcggacaaa cacctagctt tttgcgaaaa cctaataaaa 1100341 ggacagcctt ttttcgaaaa gctttgggaa atggaaaacg aatcaaaggt caactgaaaa 1100401 aaaccgctct ttgcaaagag cggttttttg attagcgtct ttttcttcca agacccatgg 1100461 cattctccat ttttttcagc attttgtttg ctgtccgatt cgctcgttcc gcgccttcat 1100521 caagaatccg gtctaattct tcagattcta tcagctcgta atagcggtcc tggatcggtt 1100581 ttaatgcgtt cactacgact tctgccaaat cacctttaaa ctcgccgtag ccttttcctt 1100641 cgtactttgc ttcaagctct tcaattgtcg tattgccgag gattgaataa attgtaagaa 1100701 ggttggaaac gcccggtttg ttttccttat caaatttgac aatgccttca gaatccgtta 1100761 ctgcgctttt gattttcttt tcaagctgct tcggctcatc cagcaatgta atataagctt 1100821 tctgattcgg atcagatttg ctcattttct tcagcggatc attcagagac atgatacgtg 1100881 caccgacttt tggaattttc acttccggaa tcgtaaagat gtcgttgtat tttttgttga 1100941 agcgttctgc aagattccgc gtcagctcaa ggtgctgctt ttgatcctcg ccgacaggta 1101001 caagatccgt tccgtacagc agaatatcag cggccatcag cggcggatat gttaacaggc 1101061 cggagacgac agcttcattg cctttggatt tgtccttaaa ttgagtcatc cgctcaagct 1101121 cgccgatata ggcgacacac tgcatcatcc atccggcctg cgcatgtgcg gggacctctg 1101181 actgaataaa caatgttgct ttttctggat caagtccgac agctaagtaa agcgccgcga 1101241 gattgcggat attctttcta agctcaagcc ggtcttgagg aacagttatc gcatgctgat 1101301 cgacgatgca aaaatagctg ttataatcat gctgcagttc gacaaactgc ttcattgcac 1101361 cgatatagtt gccgagcgtc actgagccgc ttggctgaat gcctgaaaaa atcgtttgtt 1101421 tcatgaaaac atcaacctca tttcttaaaa cataataaaa aaggctcatt cttcccctgt 1101481 aaaaaaggga cgaatgaacc gtggtaccac cctgattatt ccattaaaat ggaatcactc 1101541 tgacgtttgt aacggagact gctccggctg agcctacttt tttccagttc ggtcagctgc 1101601 tccaaagtcc attccacatt gcccgttatc tgctcccagc accgcagact ctcttcaaac 1101661 aggtgaaacg tgtactactc tttttcatag caagcttttc ttttgattgc ttcattataa 1101721 atcaattata accaattgtc atcatgaaaa aacattcttt tttccagtaa aattgtaata 1101781 atataaataa cacgagtgct gtaaaatcct taaatgataa ctgctatcag cgtaaaaaca 1101841 ggcagatatt atatgtaaaa agcaatatgg gcagaaaaca catgaaaaag tttttaatca 1101901 atttatgctt taaatggtag aaggatatta tgttcatgga agaaaaacta acgaagttta 1101961 aatattttaa attgataaaa taatattgca ataaattatt tgtttcatta taatgaactt 1102021 gttcactcta ttgttacagc ttttttacaa aaataatcag aaaagacgga acagaataaa 1102081 agttgtggaa actcaggttc atttgtctga tatttctgag gatttagccg taaggagctg 1102141 aaaattatta ttagggggtt tgcgaatatg aaaaaacgtt ggtcgattgt cacgttgatg 1102201 ctcattttca ctctcgtgct gagcgcgtgc ggctttggcg gcagcggatc aaacggtgaa 1102261 gggaaaaagg acagtaaagg aaagacgaca cttaacatta atattaaaac tgagccgttc 1102321 tccttacatc cgggattggc aaatgattca gtatcaggcg gtgttatccg tcagactttt 1102381 gaaggattga cacgtatcaa tgcagatggt gagcctgaag aaggcatggc ttctaaaatt 1102441 gaaacgagca aggacggaaa gacatataca tttaccattc gtgatggtgt gaaatggtct 1102501 aatggagacc ctgtaactgc acaagatttt gaatatgctt ggaaatgggc gcttgaccct 1102561 aataatgaat cacaatacgc ttaccagctc tactacataa aaggtgctga agcggcgaat 1102621 accggaaaag gcagcctaga cgatgtggca gtaaaagctg tgaatgacaa aacgctgaag 1102681 gttgaattaa ataacccgac tccatatttc actgaattaa ctgcgttcta tacgtatatg 1102741 ccgatcaata agaaaattgc agagaaaaat aaaaagtgga atacaaatgc cggagatgat 1102801 tatgtatcaa acgggccgtt caaaatgacg gcatggaaac acagcggctc tattactctc 1102861 gaaaaaaatg accagtattg ggataaagac aaagtcaaac tgaagaaaat cgatatggtt 1102921 atgatcaaca ataacaatac ggaactaaaa aaattccaag ctggcgaact tgattgggcc 1102981 ggtatgccgc tcggacagct tccgacagaa tccctgccga ccctgaaaaa agacggttct 1103041 ttacatgttg agccgattgc aggagtgtat tggtacaaat tcaacactga agctaagcca 1103101 ttagacaacg tcaatatccg taaagcttta acatattcgc ttgaccgtca gtcgattgtt 1103161 aaaaacgtta cgcaaggaga gcaaatcccg gcaatggctg cagtgccgcc tacaatgaag 1103221 ggatttgagg ataacaaaga aggatacttc aaagacaatg atgtcaaaac agcaaaagaa 1103281 taccttgaaa aaggcctaaa agaaatgggc ttaagcaagg catctgattt gccaaaaatc 1103341 aaattgtctt acaacactga tgacgcacac gcgaaaatcg ctcaagcagt acaagaaatg 1103401 tggaagaaaa atttaggcgt tgatgttgag cttgataact cagagtggaa tgtctatatt 1103461 gataagctcc acagccaaga ttatcaaatc ggccgtatgg gctggctcgg cgacttcaat 1103521 gatcctatca acttccttga attgttccgc gacaaaaacg gaggaaataa cgatacaggc 1103581 tgggaaaatc cagaattcaa aaagcttctg aatcagtcac aaactgaaac agataaaaca 1103641 aaacgtgcag agctgctgaa aaaagcagaa ggtattttca ttgatgaaat gccggttgcc 1103701 ccaatctatt tctatactga tacttgggta caggatgaaa acctaaaagg tgttatcatg 1103761 ccaggtactg gtgaggttta tttcagaaac gcatatttta aataaggcta cgtctgaaaa 1103821 taaaagacct caaggtatat ggggagaaaa gccccatata cctttcttac tgatggagta 1103881 taaaaatgta aaaaccatgg aggtgttccc ccttgctaaa atatatcgga agacgcttag 1103941 tctatatgat tatcacacta tttgtgattg taactgtgac attcttctta atgcaagcag 1104001 caccgggcgg gccattttca ggtgagaaaa agcttccgcc tgaaattgaa gcaaatttaa 1104061 atgcgcatta tggcttggac aagccgctgt ttgtacaata tgtcagttat ttgaaatcag 1104121 ttgcaatgtg ggatttcgga ccgtcattta aatataaagg tcagagtgtt aacgacctga 1104181 tcagttcagg tttccccgtt tcatttactc ttggagcaga agctattctc ctcgctttag 1104241 cgttaggtgt attgtttggg gtcattgcag ccctttacca taataagtgg caggattata 1104301 ccgtcgcgat tttaacgata tttggtattt cggttccgag ctttatcatg gcggctgttc 1104361 tgcaatatgt gttctccatg aagcttgggc tgtttccggt cgcggggtgg gattcctggg 1104421 catacacctt tttgccttcc atcgcacttg cttccatgcc gatggcgttt attgccagac 1104481 tttcccgttc aagcatgatc gaagtgttaa acagtgatta tatccgcaca gcgaaagcga 1104541 aagggctttc ccgcccagcg gttacagtgc ggcacgccat tcgaaacgca cttttgccgg 1104601 ttgttacata tatgggcccg atggccgcac aggtcttaac ggggagcttc attattgaaa 1104661 ccatttttgg gattccgggg cttggtgcac acttcgtcaa cagtattaca aaccgtgatt 1104721 atacggtcat tatgggtgta acggtgttct tcagtgtcat cttgctattg tgtgtattaa 1104781 tcgtagatgt gttatacggc attattgatc caagaatcaa gctttccaaa gcaaagaaag 1104841 gagcctaggc catgcagaac attccaaaaa acatgtttga accagccgca gcgaatgccg 1104901 gcgatgcaga aaaaataagt aaaaagagcc tttccctctg gaaagatgcg atgcttcgct 1104961 tccgcagcaa taagcttgca atggtcgggc ttatcattat cgtacttatt atccttatgg 1105021 caatttttgc gccgatgttc tcaaggtatg attattcaac tactaatctc ttaaatgcgg 1105081 ataagccgcc ttcaaaagat cactggttcg gaacagatga tcttggacgg gacattttcg 1105141 tccgtacatg ggtaggggcg cgaatctcaa tctttatcgg tgttgcagct gctgttctcg 1105201 atttgctgat cggcgtcatt tgggggagca tttcaggctt ccgcggagga agaacagatg 1105261 aaatcatgat gcgtatcgct gatatccttt gggcagttcc ttcattatta atggttatct 1105321 tactgatggt tgttcttccg aaaggtctat ttacgattat tattgccatg acgattacag 1105381 gctggattaa tatggccaga atcgtgcgcg gacaagtgct gcagctgaag aatcaggagt 1105441 atgtgcttgc ttcacagaca ctgggtgcaa aaacatcccg tcttctattt aaacatatcg 1105501 tgccaaacgc aatgggttct attttggtca cgatgacact gacagttcct actgcgattt 1105561 ttacagaagc ctttttaagc tatttgggac ttggtgttcc ggctccgctg gcaagctggg 1105621 gaacgatggc ttctgacgga ttgcctgcat tgacctatta tccgtggcgt ttattcttcc 1105681 ctgccggatt tatctgcatt acaatgtttg gttttaacgt tgtcggcgac ggattaagag 1105741 acgcattgga tcctaagtta cgtaaataag ggagtgatac gggtgacacg cctattagaa 1105801 gtaaaagatt tagcaatttc atttaaaaca tatggcggag aggtccaggc gatccgcgga 1105861 gtgaatttcc atctggataa aggggagacg ctggccattg ttggagaatc aggttccgga 1105921 aaaagtgtaa cctctcaagc gattatgaag ctgattccaa tgcctccggg ttatttcaaa 1105981 cgcggtgaga tcctgtttga aggaaaggat ctggtgccgc tgtccgaaaa agaaatgcaa 1106041 aatgtccggg gaaaagagat cggcatgata ttccaagatc cgatgacctc tttaaatcca 1106101 acgatgaagg tcggtaaaca aattacggaa gtgcttttta aacacgaaaa gatctcgaag 1106161 gaagcggcta aaaaacgcgc ggttgaactg ctggaattag tcggtatccc aatgccggaa 1106221 aagcgggtga accaatttcc gcatgaattt tcaggcggga tgagacagag ggttgtcatt 1106281 gccatggcgc ttgcagcgaa tccgaaactt ctgatcgccg atgagccgac aactgctctt 1106341 gatgtaacga ttcaagcgca aattttggaa ttaatgaagg atttgcaaaa gaaaattgac 1106401 acgtccatca tctttatcac acacgatctt ggtgttgtgg ctaacgttgc tgaccgggtc 1106461 gctgtcatgt acgcgggaca gattgtagaa actggtacgg tagacgaaat cttctacgac 1106521 ccgagacatc cgtacacttg ggggcttctt gcatccatgc cgacactgga aagttcagga 1106581 gaggaagagc tgactgcaat tccgggcacg ccgcctgatt tgacaaaccc gccaaaagga 1106641 gatgcttttg ccctgcggag ctcttacgcg atgaaaatcg attttgaaca ggagccgcca 1106701 atgtttaagg tatccgatac tcattatgta aaatcgtggc tgcttcatcc tgacgcgcca 1106761 aaggtagagc cgcctgaagc ggtaaaagcg aaaatgcgta aactggcaaa cacgtttgaa 1106821 aaacctgtct tagtgagaga agttgaatga attgactgaa aaactattag aaatcaaaca 1106881 tttaaaacag cactttgtca cgccgagggg aacggttaag gctgtagatg atttatcatt 1106941 tgatatctat aaaggtgaaa cattagggct ggttggtgaa tctggctgcg gtaaatcgac 1107001 aacaggccga agcattatca ggctgtacga agcaaccgat ggtgaggtgc tgttcaacgg 1107061 cgaaaatgtg cacgggagaa aatcgcggaa aaagctgctg gaattcaacc gcaaaatgca 1107121 gatgattttc caagacccct atgcatccct gaatccgaga atgacagttg ctgatattat 1107181 tgctgaaggc cttgatattc ataagctggc aaaaacgaaa aaagagcgga tgcagcgagt 1107241 tcatgaacta ttggaaacag tgggattgaa caaggaacac gcgaaccgct atcctcatga 1107301 attttccggc ggccagcgcc aaagaatcgg gattgccaga gcgcttgctg ttgatccgga 1107361 attcattatc gcggatgagc cgatttccgc tttggatgta tccattcaag cgcaggtcgt 1107421 gaatttaatg aaagaactgc aaaaagaaaa agggctcaca tacctgttta ttgcccacga 1107481 tttatcgatg gtcaaataca tcagtgaccg cattggcgtc atgtatttcg ggaaactggt 1107541 tgagcttgcg ccggcagatg agctttatga aaatccgctt cacccatata caaaatcatt 1107601 gctttctgcg attccgcttc ctgatccgga ctatgagaga aatcgcgttc gccagaaata 1107661 tgatccgtct gtccatcaat taaaggatgg ggaaacgatg gaattccgtg aagtcaaacc 1107721 gggacatttt gtgatgtgca cggaagccga atttaaagct ttttcatgat tcatcaatcc 1107781 ttcaagagat ttctcttgaa ggattttttt gcgtcttcat agaaagtgag aatgataaca 1107841 tttacaatta gaggaaaaag cggaggcgaa atacgattca atttctgcat aacaaaaatg 1107901 tttttgcgct attgctgtct caatcttttc aatctttagc aggagtcctc gtcacaatcg 1107961 ttttaatggt ccggatctat caaatgactg actccgtttt tttggcgggc cttattttat 1108021 cgttcatgtc gtttgcgagt atagcagcaa gcttttgcgt ctctccggtg cttcgcattc 1108081 tcggttttaa aaaggtgctt gcgggagcga atctgctgag agcggtcttt attatactga 1108141 tggcatacag cgtcactcat cacggacagg cattcttttg gattacgctg ctgtttgtgt 1108201 tttgtttttc cttcgcgggc gctttttttc agccggcaag atttgcgctg ctgccgatta 1108261 ttgttccaaa gaagcaatat gtaaaagcga atggtgtgat ctccctctcg aatcaattgt 1108321 tcttaacagc aggctggggc cttggaggcc ttctgacgta cgccgtccct tttgaactcg 1108381 ttgtcggcgc tgccatttgc ctgtttgttc tatcgggagc ttccatcagt gtgctgcatg 1108441 taaatgaaga agaggctgca ggaactgctg aaacagcatc tgtcagaagt atatggaagg 1108501 atttaatgat catccctatt gtaagagaca ttactgtaat ggacatgtta gaagctttgg 1108561 cgggttccgt atggtcatct gctattctcc tcgcatttac tgcggctgtt ttgcatgaaa 1108621 cagaggtgtg gtgggggatg tttaacgctt cctattttat aggcgcaatt gtcggcagtg 1108681 tgattgctat tcgtttttct tctttttttg agcggaatat gggctatgcc attatgttca 1108741 gctcgcttgt aatgtcggcg ctgacccttt tgttttcatt ttctccagtc ccatttttat 1108801 gcgctctggc ttgtgctgca atggggcctt tttatcaggt gcgtgatatt tgccaggaaa 1108861 ccatgctgca ggaagttatt cccgagcaga aacgaatcgg aatcatggct gcaaaaaatg 1108921 cgattttgac tccttggtca ggcgtcacct actccattat ggggctagtg gctgatgctg 1108981 ctggtgcgaa aatagctttt atcgcggctg ctgcattata tatcatgaca tttctgattg 1109041 cactggcgca gccccgtctg gttcattaca ggcgagaaaa tcgagttcaa tgagaaacac 1109101 ttcaaaatga acggagcagc tggctccgtt ttgctgaaaa aaaaatgaaa ccatggcgga 1109161 agttcgcacg tctttataga tgtaaggctg tttaaacaag aagaaatggg gtatatctaa 1109221 aagtatgaag acaacgaact cataaggagc aaatcaatga actggtatga aaagcttagc 1109281 gagtactttc caattgaaga aatgaaatca aaagcgcata tggaagctct tctgaaagag 1109341 cgaagcgata tttatcataa agatgaaggc aaacatcata ttttaatgtt tgcggaattc 1109401 gattctttta tcttcgttga ttatctgtat gtgtctaagg atgcaagagg gcaggggctt 1109461 ggcggcaaat tgatcgcgaa gctgaaaaag aaaaataagc ccatattgct cgaggtggaa 1109521 cctgtggatg aagatgatac tgatacagaa aaacgcctga ggttttatca aagagagcat 1109581 ttcaagcatg ctcagtcaat tgggtaccgg cgccggtcat tggctacgaa tgaagtaaac 1109641 aagatggaga ttctgtactg gtcaccaaaa acagaatcag aagaagaaat tcttgaagcc 1109701 atgaaacaga catatgaaaa cattcatact tataaagatg agaaatggta cggagaatcg 1109761 tacgaaaaaa cggatgaggt cttggaaatc atcgatgaag aaaaacaaaa aaatattttc 1109821 gatcagttaa gctaattgag aataagaaca tatcatgaac attaaaaatt tgctggattg 1109881 acacattttt ttcttaggat actgttcaca cttacttttt tatagtataa tacctgtaaa 1109941 gattcctttt ttagagtaat ttcaatttaa gaataaaata gatgttcatc ctactaatta 1110001 gaggagtgaa gatgaatggt tacactatac acatcaccaa gctgtacttc atgcagaaag 1110061 gcgagagcgt ggctcgagga gcacgagatt ccatttgtag aaagaaacat tttctctgaa 1110121 cctttatcaa ttgatgaaat aaaacaaatt cttcgaatga ctgaggacgg aacagatgaa 1110181 atcatctcaa cccgttcaaa agtattccaa aaactgaatg tgaacgttga atctatgccg 1110241 ctgcaagatt tgtaccgctt gatcaacgag catccaggtt tgcttcgccg tccgatcatc 1110301 attgacgaaa aacgtttgca ggtcggatat aacgaagacg aaatcagacg tttcctgcca 1110361 agaaaagttc gctctttcca attaagagaa gcacagcgtt tggcaaacta atagatcgta 1110421 tcatcaaaag aaggctgagt catcagcctt cttttatttt tcaacctgct ggtaataaat 1110481 gctcgcaagg atgacaaacg caaccgtcaa aatggggagg agcgtttcga ctgtgccgtg 1110541 ctgcgccata aaaagcgaca gctttttgtc tctgacaatc atttctccgc cagtataagc 1110601 aagcagcccg cttcccgcgt aaatcagaag cggtattttc tctagtgcaa tatggatgag 1110661 tttgctgccc caaataataa ccggaaccga tacacacaat cctataacaa cgagagaaaa 1110721 ctcaccgtgt gaagctcccg caactgcgat gacgttgtcc agcgacataa agagatctgc 1110781 aagcacaatc gttcgtatcg ctctccacag ggaggtgctg cttttaatgt gtttcgtgtc 1110841 ttttttttca atcagcagct gatatcctaa atacagcagg aaaattccgc cggcgcactg 1110901 caagaacgga atgttcaaaa gatatactgc tgcacttgtt aatccgattc tcatggcaac 1110961 ggcaataaat gttccgagaa taatggcttg ctgtctttgc ttgtccggca aatgtctgct 1111021 ggccatggca ataacaaccg cgttatctcc gccgaggatc aggtcaatcc caacaatgac 1111081 gagcagagaa atcagatagt catgctccat gaagcggcac ctcgctttca gtccttcgct 1111141 tgtactacta ctatatgaga caggtcatat tttatgatat cagccgcctg atctgccgtt 1111201 ttttaggcaa aggtgcattt ttatttcttt tgtgactgtt ttatcataaa atagaaatac 1111261 aaaggaattc acactggcct tggttaaggt taagatgtgg acggaatggg taaagtgtag 1111321 taaagtacaa ttaatcggga gcttagatgt cccttcaaca tcttatatag aagggaaggt 1111381 tggcaaatgg aaattgaaag aattaacgag catacagtaa aattttatat gtcttacgga 1111441 gatattgaag atcgcggttt tgacagagaa gaaatttggt ataaccgtga gcgcagtgaa 1111501 gaacttttct gggaagtcat ggatgaagtt catgaagaag aggaattcgc tgtggaaggc 1111561 ccactttgga ttcaagttca ggcactggac aaaggattag aaatcatcgt cacaaaagcc 1111621 cagctttcca aagacggaca aaagctcgaa ctgccgattc ctgaggataa aaagcaagaa 1111681 ccagcatctg aggatcttga cgccttgctg gatgatttcc agaaagaaga gcaagccgtc 1111741 aatcaggaag agaaggagca aaagcttcaa tttgtcttgc gatttggcga ttttgaggat 1111801 gttatttctc tatctaaatt gaacgttaac ggaagcaaaa cgactttata ttcgtttgag 1111861 aaccgatatt atttatatgt agatttttgc aatatgactg atgaagaggt tgaaaatcag 1111921 ctaagcatcc tgctggagta cgcaactgaa tcctcaatca gcatacaccg tcttgaagag 1111981 tacggcaagc tgattatttc agagcatgct ctagaaacga taaaaaaaca ctttgcatca 1112041 tagcaaaccg atttccttcc ggaaatcggt tttttttatg cacgaaaatg ccattttaga 1112101 gatgtgaaaa atcaaaaaca tatagacaag cagaaaatac agcgaacagg agttgatcat 1112161 cttttccaga aagtatactt catctggaaa ggagagatga caattgttta gtgctgtgac 1112221 tgaagacggc caaatgtttc accttctagg cgctcagcaa aaccagaaat taaagcggag 1112281 acggttcttc tgtccggtat gcgggggaga gctagctgtg aagctcggac ttcaaaaagc 1112341 gccgcatttt gcccataaac agaacaagtc ctgcgccata gacatcgagc cggaaagcgc 1112401 ctaccactta gaaggaaaaa gacagctgta tgtatggctg aaaacgcaac gggcttcacc 1112461 aatattggag ccgtatataa ggacaatcaa ccaaagaccg gacgtcatgg caagaatcaa 1112521 ggagcatatg cttgctgttg aatatcaatg cgccactatc gctccagatg tctttcaaaa 1112581 gcggacagag ggcttcaaac aagaaggaat catcccgcag tggattatgg gatacagccg 1112641 cttaaaacgg actgcttcgt ccttttatca gctttcaact tttcattggc agtttatcaa 1112701 tgcaagtcca tacagagaac tgatatgtta ttgtcctgaa aggcgttctt ttctccggct 1112761 cagccacatc attccattct acacaaacca ttcttattcc tcagtccaaa cgatccctat 1112821 ccatcgggca ggtgcaggcg atcttttttt cactgaaccg aaaccctcaa ttcaatattc 1112881 aggctggacg aaagcgattc accgttttcg ccataaaccc catcggttta actcaaagga 1112941 aacaaatcgc cttaggctgc tgttttatga gaaacgacag acgccttttt cttttctgcc 1113001 gactgaagtg tttgttcctg ttagaaaagg ggcagttttt aagagtccgg tttttgtgtg 1113061 gcaggggttt ctttatttgt ttatgacgga tcttggaggt aaacgtgcgc caattcgttt 1113121 ttcagccgtt ttgcagcagt gcaaactgca cattcataat aagaacattg cactcaggtc 1113181 cgaatgcagc gaagagtgtc tttcagaagc ggttaaacag tatattgatt ttttgtgcaa 1113241 gaagggattt ttaagggaga ctcagaaaga agtatatgtg ctgaatcagc ctgcaggagg 1113301 catacactcc atgcaggatc tcatagaaag agaccgcagc tgttttatag aatgagtttg 1113361 tcttatttgg ctcaccctaa gacaaaggtg gtgggcaggc tgtgaaaggc acaaaaggaa 1113421 aggtttttcg tgtttttact gcttttttgg cattcgttct cttcattact gcatatgatt 1113481 tgacaaaagg cagtgaaaaa ccggaagata ttcacaacac aagtttattg agaaacagct 1113541 gttttttcaa ttggcttgaa tcaaagaaga cgagggggat caccatggct gaggaaaaaa 1113601 aagcaaacca actgcctgac agaagtgagg taaaggcaga agacacatgg agacttgagg 1113661 atatttttcc tagtgatgag gcctggaata aagaatttca agctgtaaaa gaattaattc 1113721 cgaatttatc taagtataaa ggaaagctgg cagattcagc tgatcattta tacgaggctc 1113781 ttacgtatca agataaagtg atggagcggc taggtaggct gtacacatat gcgcatatgc 1113841 gctctgacca ggatactggg aactcctttt accaggggct gaatgacaag gcgggaaacc 1113901 tgtatacaca ggccgcaagc gcgacagctt atttggttcc ggagatttta tccatagaag 1113961 aagacaaact gcagcagttc attcttgaaa aagaagaatt gaagctgtac tctcatgcga 1114021 ttgaggagat tacaaaggaa cgtccgcatg tgctgagcga gaaggaagag gcgctgcttg 1114081 ctgaagcctc cgaggtactg gggtcatctt caaatacatt cagcgtgtta aataacgcag 1114141 atataacgtt tccatccatt aaagacgaag atgggaatga aaaacagatc actcacggca 1114201 actttattaa tttcttggaa agtgaaaacc gtgaagtccg caaaaatgcg tttgacgcag 1114261 tgtataaaac gtacggacaa tataaaaaca caatggccac gacgctaagc ggcactgtga 1114321 aaaaggacaa cttctacgcg agagtgaaaa agtacaagtc cgcgcgtgag gctgcgcttt 1114381 ctaacaacag tattcctgag gaagtatacg ataaccttgt taagacgatt aataagcatt 1114441 tgccgctcct gcaccgctat attgcgctaa gaaagaaagt gcttgagctt gatgaagtgc 1114501 atatctatga cctgtataca ccgcttgtga aagatgctgg gatgaaggtg acatacgagg 1114561 aagccaaaga ttacatgctg aaaggcctcg cacctttagg ggaagaatat gcctctatcc 1114621 taaaagaagg actggaaaac cgctgggtgg acgtttacga aaataaaggc aaacgcaatg 1114681 gggcttattc atcaggagct tacggcacga atccgtatat tttgatgaac tggcataata 1114741 acgtcaataa tctctttacg ctcgtgcacg agtttggaca ttccgtacac agctactata 1114801 cgagaaagca ccagccttat ccatacggca attacagcat ctttgtcgcg gaagttgcct 1114861 ctacgacaaa tgaagcgctc cttggcgaat atttgctgaa caatttagag gatgaaaaac 1114921 agcgcttata tattctcaac catatgcttg agggcttcag gggaacggtc ttcagacaaa 1114981 cgatgttcgc tgaatttgaa catctgattc atacaaaggc gcaagaaggc gagccgctta 1115041 cacctgagct tctgacaaat gtctattacg acctgaataa aaagtatttt ggagacggca 1115101 tggtgattga taaggaaatc ggccttgaat ggtcgcgtat tccgcacttc tattacaatt 1115161 actatgtgta tcagtatgcg acaggttaca gcgctgccca agcattaagc agccagattt 1115221 tgaaggaagg aaagccggcg gttgaccgtt atattgactt cctgaaagcg ggaagctcac 1115281 aatacccgat tgatgtcctg aaaaaagcgg gtgttgatat gacgtctcca gagccaatcg 1115341 aagccgcgtg caaaatgttt gaagaaaaac ttgatgaaat ggaagagctg ctgatgaaag 1115401 tcaagcagtc ttaaaaaagt aagcctgtgc ggaaatgacg cacaggcttt tttaaaaccc 1115461 tttaaaggtt ttccggtgat tcaagcggta gagggtaaac aaaatagaca gaaacagcag 1115521 aggagaggta atataaagcg gcagcatatg catcatgcct aagatattca agcagaaaaa 1115581 aacagcaatg cacacaattg agatcaaagt agacatcatg gcggtcctcc tcgtcctttt 1115641 tccttataag gatatgagtg aatgcacttc gttatgtttt gtgacaaaaa tatgaacatt 1115701 aagcatagag gttgtcaaaa gtcgacatct tttgttatca taaggatgtg aaattgatca 1115761 caaacaaaca ttaccccttt gtttgaccgt gaaaaatttc tcccatcccc tttgttgtcg 1115821 ttaagacata tgaaaccgcg cttatcccgg cgcggtttct ttagtgctaa aaatggaacg 1115881 tacgtttggt tatggcataa aaaaacagcc tcaagcatat gcacgcctgc ggctattttt 1115941 cacatgattg atattcatca gaataagtgc tgagagactt ccaaaacatt ccgtgtttgg 1116001 cttccacttt ggcaaccttt ttagcaaacg ccagtttttt catttctttt tctacctctt 1116061 caaggctcag gtcatataca agagcaattt ccttcgaggc aacgaagcgg aaatattcaa 1116121 taaaacattc taaaggcggt gtttccgacg gcttcggctc gtcgccaagc atctcaaata 1116181 aaatttcttc atatacatca tatgagtagc tgccaggaac tttaagccct tcatcctcat 1116241 gctgcgtatt aaaaaacgtc agtgtcggat taacagaaac atccatctcg gcagcaattt 1116301 tcatgtcaca ttgaagcgcc ttgaccgcgc tttgagaatg cagatctttt ttgaattctt 1116361 caagatcgag acttgtattt tcagcaatct ccaaaagcac gttttcatcc gtaatatttt 1116421 tctttgaaac aaataggctc tcctgcatat ttctgagaaa ttgcatgccg gcttttcgtc 1116481 cttgcagttc ggctgcttta aaagcgagag cagccatata aggcgatgaa agcggctgat 1116541 cctgttcgaa ccagacattg ccgtcacatg acatgccaga gcggctcgcg atcttttccc 1116601 atgcttctgc gagaagatgc ttttttcgct ttttatttaa agcggtaagg cttgcggaag 1116661 cgataatgcg taaggtgaaa aaacgtccgt atctgatttt cagctttttg atgacgggct 1116721 ctaaggacca gcattcagga cataaagggt ctacaaacat ataaatttca agcggttttt 1116781 ttggatgacc gtggcaatgg gcgaagtata gctcatgctg atagtttgtc aagatgatcg 1116841 atcctccgct tccgtttgat tcaccatatg ccttgctgtc aactccagcc ggccaaacaa 1116901 aaactcacga atttcgccct ccagccctac atggtccatt gcgtccttca tacagctgag 1116961 ccacgcatca gctctctcgt ttgtaattgg aaagggaaga tgccttgctc tgagcatagg 1117021 atggccgtgt tcctcagtat aaagaggagg cccgcctaaa tactgagtta agaattgctt 1117081 ctgtttcctg gcggtttctg tcaaatcgct tggaaaaatc ggcttcagca aaggatgaga 1117141 cgcgacacgc tcataaaaag tatcaacaag ttgcgataga agttcctctc caatcgcttc 1117201 ataaggtgcg ttaaacgatt gtcccatgtt gactactcct ttaaatatgg ctaataggaa 1117261 tcataaatcc tattgcaaaa agtaattttc tgtatttcat tgtttcatct agatttattt 1117321 tagcaacaag gcatcatttc tacaaacaaa ctgcctttta tgcgtttgat gactcatttc 1117381 ggctgacagc cggggtttgt atttcatatc atatcacata aaaatcagga atgcgtaaga 1117441 tttcacttcg caaaaaaacc agagggaaag agcacctctg gttacgcgta ataaactgaa 1117501 gttatttttt ttacatagtt ttgcgtttct tggaaaggag gaatgcctcc gtatcggtca 1117561 acattccccg gtccggcgtt gtaagccgct aatgccatag acacattgcc gtcgtattta 1117621 tccagcattt gttttaaata tttcgttccg ccctccacat tttgctgcgg atcaagcgga 1117681 ttggaaacgc caagtgagct tgctgttgac ggcatcagct gcatgaggcc catcgcacct 1117741 gctccgctga ccgcttttgc attaaagcct gattcctgtt tgatgacggc gcggatcagt 1117801 ttttcatcaa cgccatattt atcagcggct tttttaatcg cactgtcaat agagaagtct 1117861 cccgaacgga tctgatttgc ttcatgtttg tttgaagctg aatctgcaac agctgtttca 1117921 gtgctttctg ccgcttttgt gactgaacct gaattgctgc tcgtatatga gttaagccca 1117981 tacgctgaaa gcagtgacgg cgctgttgta ttcgcgctgt tcagcatgct gagcgggctt 1118041 ggcgatgaag aaggtgctga ttgctgagat gtcagaccgt ttgtatattg gctgagcaaa 1118101 gaactgaaac ttgaaagcgg gctttccgta ttctgagtgt ccgagctgct gcgtgcatta 1118161 gatatggact gtaatgcctg aagctgaagt aatgctgccc aattcgttac attcacgatg 1118221 tcattccacc ttatatagac tttcgttttt cttcataaaa acgcagaatt ttatttttgg 1118281 tttcgcgctg aggaatgctg aattgctgaa gcagcttttc gaaggcttgt ctgccctcat 1118341 gccaatccgc cgcctcaaat tcaatttcat agtcctcttt atttaaatat cggctgtggt 1118401 ctaaaactat taagcctttt tctgtttctt tttccgcacg gtttgttgct aaagatccaa 1118461 agtattgtat ggcatccgta tcgatctgaa gcttgtgcag ctggtccttc acagggccct 1118521 cgggaactga aaatccagcg agatctgata cctctgaaag ctgctggtgc gtttccagaa 1118581 gccccacatc agccggctcc tttaatgtaa ggacatactt tccgtttttt ctgcggatac 1118641 gaagcgcagc atgtttttgt ttcagcgcga agctgtctgt atcaaaataa tgattctttt 1118701 gatctgtaaa atctttttct gtcagctgga gtgccgatgc tatgtttttg aattcttgtt 1118761 tggtcagcat gtttttaaat tcgatttcaa tctcttggct catgatgctc ttcctttccg 1118821 ccctgtaaat cttattttta ctattatctc tttagatgtt aggtttatca atatcgagct 1118881 cgatatgata aaatgaatct gtactttgtt taaaaaagga gagcattatg caaaacagaa 1118941 tcgaaatttt gaatgcaaca ttatcggatg atcagcttcg ccttgcctgt cagacagaag 1119001 gaaacgaagc ggaacgcaag ccgtcaggtc aaatgcttgt tgattctgac cactttgctt 1119061 ttgtatacat acttgaatta gctgattctt ttgaatatgt cattataaag gaacatgtat 1119121 ggccggaact gaagcaggcc catgcacaaa aaataccggt tgttttagag gcaggagacc 1119181 aaacaattga actggcaggc ctgcatgagg agctggaata tcttttagaa aatataaaag 1119241 ataatgcaaa ctatggagaa gaaatggaag aaaaagtgaa acgcgtgttt ttatagaaac 1119301 tggttcggaa ttgggggatg tatgatggat gacaaacaat gggagcgttt tttagtgccg 1119361 taccgccagg ctgtcgaaga gttgaaagtg aagctcaagg ggatccgcac actatatgaa 1119421 tacgaggacg accattcacc gatcgaattt gtgaccggac gcgtcaagcc tgtggcgagc 1119481 atacttgaaa aagcgagacg gaaaagcata ccgctgcatg aaattgaaac catgcaggac 1119541 attgctggcc ttagaatcat gtgccaattt gtcgatgaca tccaaatcgt aaaagagatg 1119601 ctttttgcca gaaaagattt caccgttgtg gatcagaggg attatattgc ggaacataaa 1119661 gagagcggat accgatcata ccatcttgtt gtgctgtacc ctttgcagac ggtatccgga 1119721 gaaaagcatg ttctcgtaga aatacagatc cgtacactgg cgatgaattt ttgggcgacc 1119781 attgaacatt cattgaatta taaatacagc ggaaacattc ctgaaaaagt aaaactaagg 1119841 cttcagcgcg cttctgaagc ggcttcccgg cttgatgaag agatgtcgga gatcaggggt 1119901 gaagtacagg aagctcaagc tgccttttca agaaagaaaa aaggaagcga gcaacaatag 1119961 gtaaagggga agaagagcat gaaatttgcc gtatcatcaa aaggagatca agtttctgat 1120021 acgctgaaaa gcaaaataca ggcgtattta ttggattttg atatggaact ggatgaaaat 1120081 gaaccggaaa tcgttatttc agtcggaggc gacggaacgc ttttgtatgc ttttcacaga 1120141 tacagcgacc gtttggacaa aacagcattt gtcggcgttc acacaggtca tctgggtttt 1120201 tatgccgact gggttcctca tgaaattgaa aaacttgttc ttgccatcgc gaaaacgccg 1120261 tatcatacag tcgaatatcc gcttctcgaa gtcattgtga cctatcacga aaacgagcgg 1120321 gaagaaagat acttagcttt gaatgaatgt acgattaaaa gcatcgaagg aagccttgtt 1120381 gctgatgtgg aaatcaaagg gcagctcttt gaaaccttcc ggggcgacgg cctctgcctg 1120441 tcaactccat caggcagcac agcctacaat aaggcgctgg gcggagcgat tatccatccg 1120501 tctatcaggg cgatccagct tgcggaaatg gcttcaatta ataaccgcgt gttccgtacg 1120561 gtcgggtcac ctctgcttct cccatcccat catgattgca tgattaagcc gagaaacgaa 1120621 gttgactttc aagtgacgat tgaccattta acccttctcc ataaggatgt aaagtcgatc 1120681 cgctgccaag ttgcatccga aaaagtgcgg tttgcgagat tccgtccgtt tccattttgg 1120741 aaaagagtcc aggattcgtt tattggaaaa ggtgaataga aagaggacat atcgtggagc 1120801 atttttttat cagaaagaac attacttccg ctgaggacgg gatgactgta aaagaatatg 1120861 ccggtgaact gggaatttcg aaacgtctgc tgaccgatat taagtttggc gggggagacc 1120921 tgcagattaa cggtgagcat gtgacggtca aatacgtttt gaaagaggga gatcttctta 1120981 tcgtgaagtt tcctgaggag caggtgagcg agacgctgtt ggcagagcct gttccgctcg 1121041 atatccttta tgaggatgaa catgtgcttg tgataaacaa gcagccgtat gtgtcatcaa 1121101 tcccttcgag agagcacccc tccggcagca ttgccaatgg aattattgat cattatcaaa 1121161 caaccggagt gagggcgaca gttcatcttg tcacccggtt agaccgggat acatcaggta 1121221 tcatgcttgt tgccaagcat cgatttgccc actccatttt atcgtctgcg caaaaaaacg 1121281 gccttgtgaa acgccggtat gcggcagtgg ttcacgggcg gatggcacag atggagggaa 1121341 cagtcgatgc tccgattggc agacatcctg acagtattat tgaacggacg gtaacgccag 1121401 acggccagaa ggctgttact catttttacg tcacatgtgc aaatgatgac atgacctcgg 1121461 tggcattgca gcttgagact ggacgaaccc atcaaattcg tgttcatatg agctatctcg 1121521 ggcacccgtt gtgcggcgat acactgtacg gcggaacgag acaggaaatt ggccggcagg 1121581 ctctgcacag cgagcatctt tcgtttatcc atccgctgac acaggagaac atgaggtttc 1121641 atgctccact gcctcaggac atgagcaaac tgataaaagg agagaatcat tgattctctc 1121701 cttttttata tggggcgaaa tcttgattcg tcgtaaggca gggagcttgg aacagagacg 1121761 gtttctattt ctggaaagcg aaagcctgtc agttgatttc cgaacacgca gcctgtatca 1121821 atgttgatgg tgcgattgac cttccgaggc tctttcacag gtgtatgacc gtataccacc 1121881 caagcctttc cgttataggc tgccgcccaa tcacgcctga tgggtctgcc gtccggatat 1121941 gtttcacccg tcacgtcacc gtaaagcaca aagtccttca ctctgcgggt atatttgccg 1122001 atatcgtcag ctcttatgcc agcatgggcg acaactaatt ctccattatg taagatgtcg 1122061 taaagcggcg ctgtttcgta cagcttcata aactgttcgc tgactgattt tttctcatct 1122121 ttggaaagtt cctcaagctc tgccgctgtt gtttcgagac catgcatcac ttttaccgga 1122181 tttcctttta agtaacgata taatttattg caatggtttc ccgggacata acgcacagcg 1122241 cctttttcgt aagcgccggc tacaaatcgg atgacctcta tcgatttggg ccctctgtca 1122301 gttaaatctc cggcaaaaac aagcaccctg ccttcttcat ggacaggtac tccatttttg 1122361 attgtatagc caagcttttg gattaatgca gtcatttcgt catagcagcc atgaatatcg 1122421 ctgatgatat cgtaagccat gcggtctcct ccttaccgat tgttttattt attatgaagc 1122481 aaagtgttgt gagtcatcac aagcttttat gtgcaaatta tagaagaaga atcattttct 1122541 aaacaggatt aagaccttat cactttattt ttcatcatca cccttgttaa aatcgcgtta 1122601 tgttttttaa aaatgaggtt ttgttctctg agtgagaact agcataaccc tgacttaaaa 1122661 aggaggttct gattatggcg catacatctg tcgcatcttt agttgttgta cttatcgttg 1122721 catttttgac acccatcctt ttgcatcggt ttaaactcag catcccggtt gttgttgctg 1122781 aaatcattat ggggctgata attgggaaaa gcggccttaa tttagttgtg gagggtgaca 1122841 cctggctcca gacactctct atgctcggat ttatcttttt aatgttttta agcgggcttg 1122901 aaattgattt ttcgtcgttt gagaaaggaa agaaaaagca gttcctgccg aatggcaagg 1122961 aagcgccgaa tacgtttgct gcggcatctg ttattttcgt cggtattttt attttatcat 1123021 tgctcttgtc ctatgggttc gtcttggccg gatttatcca aaatgcattt ttgatgaccc 1123081 tgattatttc aacgatttca ttaggcgttg tcgttccaac attaaaagaa gaacggatca 1123141 tgaattcgaa tatcgggcag attattttgc ttgttgctgt tattgctgat ttggccacga 1123201 tgattcttct tgctgttttt tcttctttat acggagagga cagcggaaac atgtggctcc 1123261 tgatgattct gtttgcggcc ggagtggtgc tttacttttt cggccgggtc ttcaaacatc 1123321 gctcttttgt tcaatccatg tcaaaaggga cgatccagat cgggacgcgt gccattttta 1123381 cgttaatcat tgtactcgtt gccctgtctg aatcacttgg ggcggaaaat attctcggcg 1123441 ctttcttagc gggggttctt gtttccctgc tttcgccaaa caaagaactt gttcagcagc 1123501 tggactcatt cggttatggg ttcttaatac cgattttctt cgtgatggtc ggtgtgaagc 1123561 ttgatatttg gactcttttc caggataaaa caattttaat catgattccg ctcctgctgc 1123621 ttgcgctgtt agtcagcaaa atcattcctg tcatgtactt aaagaagtgg tatgataacc 1123681 gaaccatttt cgcgtctggt ttcctgctga catcaacgct ttcgctcgtg attgctgctg 1123741 caacaatcgg ccagcagctt cacgtgatca gtacaaatat gtcaggagcg ctaattttag 1123801 tagccgtcat tgcaagtatt tttacgccga tctgttttaa aaaattatac aaacgggaag 1123861 agcagccgga ggagaaaaag acgattacgt tcattggcgc caatcaaatg actttgcctg 1123921 tcacactcga attgccagag gaagagtatg acgtgcgtgt tgtacacgtc taccaagaga 1123981 atgcggagga aaagctgtca gaatcagtgt ttgctgttga aacaatttct gactatgaac 1124041 acgagacgct tgaatcactc ggcatttttg aaacggatat cctcgttgtg gcgacaggaa 1124101 atgaagatat gaatgcagac attgcattac ttgcaaaaga taaaggcaca gaaagagtca 1124161 ttgcaagcgt aggatcaccg gagcatgaag cagctctgaa ggagcaggga atcagcatct 1124221 tttctattct gctgtcgaca aaaacgctgc ttcgcgcact gattgaagcg cctggcgtca 1124281 tgaagctgct cacgaaccaa gagtcttcgc tgtatcaaat taatatggag aacagtaaat 1124341 atgatggtgt cattttacgg gaattccctt taacaggtga cgtcatcttt gtcaggatct 1124401 tcagaggtgt ggacagcatc gttcctcatg gggatacgag gctgaaactt ggagaccgtt 1124461 taattgtcac cggatctcgg gggtacgtaa cggatcttaa gaaaacattg gaaggataaa 1124521 tcttgaccaa ataaggattc gtgttaatat agaggtgcag aacaattcaa tatgtattcg 1124581 tttaaccact aggggtgtcc ttcataaggg ctgagataaa agtgtgactt ttagaccctc 1124641 ataacttgaa caggttcaga cctgcgtagg gaagtggagc ggtatttgtg ttattttact 1124701 atgccaattc caaaccactt ttccttgcgg gaaagtggtt tttttatttt cagaggggga 1124761 atgatttgtg aagttttcag aagaatgccg cagtgcagcc gcagaatggt gggaggggag 1124821 ctttgtccat ccgttcgttc aaggaatcgg tgacggaacg cttccgattg accgttttaa 1124881 atactacgta cttcaggatt cctattattt aacgcatttt gcaaaggtgc agtcatttgg 1124941 tgccgcttat gcgaaggatc tttatacaac ggggcggatg gcaagccatg cccaaggtac 1125001 atatgaggcg gaaatggcgc ttcatcgcga gtttgccgag ctgttggaaa tcagcgagga 1125061 agagcgtaag gcgtttaagc cgtctcctac ggcgtactct tatacatccc atatgtaccg 1125121 ttcggttttg agcgggaatt tcgcagaaat cttagcggcc ctgctgccat gctattggct 1125181 ctattacgag gttggtgaga aattgctgca ttgtgatccg gggcatccaa tttatcagaa 1125241 gtggattggc acatatggcg gtgattggtt tagacaacag gtcgaggagc aaatcaaccg 1125301 ctttgatgag ctggcggaaa acagcacgga ggaagtgcgt gccaagatga aagagaattt 1125361 tgtcatctcc agctactatg aatatcaatt ttggggaatg gcctatcgaa aagaaggctg 1125421 gtctgacagc gccataaaag aggtggagga atgtggagct tcacgccata acggatgaca 1125481 gcaagccggt agaagagcta gcgagaatca tcattacgat tcagaatgaa gttgatttta 1125541 ttcacattcg ggaacgctca aaatcggcgg cggatatttt gaaactgctc gatcttattt 1125601 ttgaaggcgg tatagataaa cgaaaattgg tgatgaacgg gcgcgtggat attgcacttt 1125661 tctctactat tcaccgcgtg cagctgccaa gcggcagctt ttcaccgaag cagatcagag 1125721 ccagatttcc acaccttcat atcgggaggt cggtgcattc actggaggaa gcggttcaag 1125781 cagaaaagga agacgcggac tacgtgctgt tcggccatgt gtttgaaacg gattgcaaaa 1125841 agggtcttga aggcagagga gtatctttgc tgtcagatat caaacagcgg atttccatcc 1125901 cggttatagc catcgggggg atgacgccgg acaggttaag agacgtaaaa caagcagggg 1125961 cagacggcat tgctgttatg tcaggaattt tctcttccgc tgaacctttg gaagcagcca 1126021 gacgatattc ccgcaagcta aaggagatgc gctatgaaaa ggcattatga agcagtggtg 1126081 attggaggcg gaattatcgg ttccgcaatt gcttattatt tggcaaagga aaacaaaaac 1126141 accgcattgt ttgaaagcgg aacaatgggc ggcagaacga caagtgccgc tgccggaatg 1126201 ctgggcgccc atgccgaatg cgaggaacgt gacgcgtttt ttgatttcgc tatgcacagt 1126261 cagcgtctgt acaaaggtct tggagaagag ctttatgcat tatccggtgt ggatatcagg 1126321 cagcataacg gcggtatgtt taagcttgca ttttctgaag aagatgtgct gcagctgaga 1126381 cagatggacg atttggactc tgtcagctgg tattcaaaag aagaggtgtt agaaaaagag 1126441 ccgtatgcgt ctggtgacat ctttggtgca tcttttattc aggatgatgt gcatgtggag 1126501 ccttattttg tttgcaaggc atatgtgaaa gcagcaaaaa tgcttggggc ggagattttt 1126561 gagcatacgc ccgtcctgca tgtcgaacgt gacggtgaag ccctgttcat caagacccct 1126621 agcggagacg tatgggctaa tcatgttgtc gttgccagcg gggtgtggag cggaatgttt 1126681 tttaaacagc ttggactgaa caatgctttt ctccctgtaa aaggggagtg cctgtccgtt 1126741 tggaatgatg atatcccgct gacaaaaacg ctttaccatg atcactgcta tatcgtaccg 1126801 agaaaaagcg gaagactggt tgtcggcgcg acaatgaagc cgggggactg gagtgaaaca 1126861 ccggatcttg gcggattgga atctgttatg aaaaaagcaa aaacgatgct gccggctata 1126921 cagaatatga aggtggatcg tttttgggcg ggactccgtc cgggaacaaa ggatggaaaa 1126981 ccgtacatcg gcagacatcc tgaggacagc cgtattttat ttgcggctgg ccatttcaga 1127041 aacgggatcc tgcttgctcc cgcaacgggc gctttgatca gtgatctcat catgaataaa 1127101 gaggtcaacc aagactggct gcacgcattc cgaattgatc gcaaggaggc ggttcagata 1127161 tgatgctaca gctgaacggt aaagacgtga agtggaaaaa agacacaggt acaattcaag 1127221 acctgctggc gtcgtatcag cttgaaaata aaatcgttat cgtggaaaga aataaagaaa 1127281 taatcgggaa agaacgctat cacgaggttg agctttgtga tcgtgatgtc attgaaattg 1127341 tccattttgt aggaggcgga tgagcatgtt aacaattggc ggaaaatcat ttcaatcaag 1127401 attgctgctg ggcacgggga aatacccatc gtttgacatt caaaaggaag cagtagctgt 1127461 ttctgagtct gatattttaa catttgctgt aaggagaatg aacatttttg aagcatctca 1127521 gccgaatttt ctggaacagc ttgatttatc caaatatacg cttttgccga atacagcggg 1127581 cgccagtact gctgaagaag cggttcggat tgcaaggctg gcgaaagctt caggcctttg 1127641 tgacatgatt aaagttgaag tcatcggatg cagccgttcc ttgctgcctg accctgttga 1127701 gacattaaaa gcgtctgaac agcttcttga agaaggcttt attgtgctcc cgtacacgtc 1127761 ggatgacgtt gtgctggcga gaaagctgga agagctcggc gttcatgcca tcatgccggg 1127821 tgcatctccg attggatcag gacaaggaat cttaaatcct ttgaatctgt cgtttattat 1127881 tgaacaggcg aaagtaccgg tcatcgtgga tgcgggaatc ggctcgccta aagatgcggc 1127941 atacgcaatg gagcttggag cggatggcgt actgctcaat acggctgtat ctggcgctga 1128001 cgatcccgtg aaaatggctc gtgccatgaa gctcgcagtg gaagcagggc gcctttctta 1128061 tgaggcgggc cgaatcccgc ttaagcaata cggaacggca agcagtccgg gagaaggtct 1128121 tcctgtatga caggcaggta ttcaaggcag gagctgtttg ctccgatcgg cccatccggc 1128181 cagaaaaaat tgaaagaagc gcgcgccgtg attatcggcg ccggcgcgct cggaacagcc 1128241 agtgcagaaa tgctggtgag agcgggagtc ggctctgtga aaattgccga cagagattat 1128301 gttgaatgga gcaacctcca gcgccagcag ctttatacag aagatgatgt caaaaaagaa 1128361 atgccgaaag cagccgctgc ggagcgccgt ctccgttcga ttaacagcga tgttgatgtg 1128421 accggccttg tcatggatgt gacagcagaa aatatcttcg agctgattag ggatgcatcg 1128481 attattgtgg atgcggctga taattttgaa acccgcctga tcgtaaatga tgctgcggta 1128541 aaggaaggga ttccttttct ttacggtgcc tgtgtaggga gctacggtct tacctttacc 1128601 gtggtgccgg gttctactcc ttgcctgcat tgcttgctcg atgcacttcc gattggcgga 1128661 gcaacatgtg acacagctgg catcatcagt ccggctgttt tgcaggtagc agtctttcag 1128721 gtaacagatg cactgaaact gctgacggga gaggagtgcg agccggtgct gcgctccttt 1128781 gatttgtgga aaaacgagcg gtcagaagtg agagcggcca gtctcaaaca tgacgcatgc 1128841 ccaagctgcg gcacaaagga ttttccgttt ttgtcttatg aaaatcaaac aaaagcggct 1128901 gtattgtgcg gcaggaacac ggtgcagatc agatcatcta ttacgaaaga agcggatctt 1128961 gaagcgcttg ccggtcagct gaggcaggcc gggcttgaag tagctgcgaa cccgtattta 1129021 atttcctgcc gctcggatga tatgaaaatg gtgctgttcc gggacggcag agctttgatc 1129081 catggaacaa atgatattgc ccgggcaaaa tccatttatc ataaatggat tgggtaataa 1129141 aaggagtgta gtgtaatgag tatatataaa gcattgacaa tcgccggatc agattcaggc 1129201 ggcggcgcag ggatacaggc tgatattaaa acctttcaag agcttgatgt attcggaatg 1129261 tctgcgatta cggcggtaac cgctcaaaat acgcttggcg ttcacggggt gcatccgctg 1129321 actgtagaga cgttgagaca gcaaattgac gctgttgctg aggatttgag accggatgca 1129381 gttaagacgg gaatgctctg gaatgccgac atgattgaag aagtggcaag aaaaattgac 1129441 gagtacggat tcaatcgtgt aattgttgat ccggttatga tcgcaaaggg cggggcatcc 1129501 ttgctgcgtg atgagtcagt tgccacctta aaggagttgc tcattccaag aagctacgcg 1129561 attacgccga atgtcccgga agcagaaacg ctgacaggaa tgacaatcag ctcgctggat 1129621 gaccggaaaa aagcagcgga gcagctcgtc aagatgggtg cgcagcatgt cattatcaaa 1129681 ggcgggcacc agcctgagga caatcacatt actgaccttc tttttgatgg cagcatgttt 1129741 atgcaaatca cccatcctta tatcaatacg aagcatacgc atggcacagg ctgcaccttt 1129801 gctgcggctt taacggccca aacggctaaa ggagacagca tccatcaggc atttgaggtt 1129861 gcggccaact ttgtccgtga agcggtggaa aatacgctcg gcatcggatc gggacacggg 1129921 ccgacaaacc atttcgcttt taaacgaaac agcttaaata caagccgatg agatcaccag 1129981 ctgatggtga tctcttttgc gtttgctacg gtatgcgctt ttcatctgga caaggttatg 1130041 atatgatagg aattaagatc aggtactaat actatgtctt tattaaatat aggaggcttt 1130101 atacatatga atttttcact tgaaggccgt aacattgttg tgatgggggt agccaacaaa 1130161 cgcagcatcg cctggggcat tgcgcgttct ttacatgaag cgggtgcacg tttgattttc 1130221 acatacgctg gtgaacgcct ggagaaatcc gttcacgagc ttgccggaac attagaccgc 1130281 aacgattcca tcatcctccc ttgcgatgtt acaaacgacg cagaaatcga aacttgcttc 1130341 gcaagcatta aggagcaggt cggtgtaatc cacggtatcg cgcattgtat cgcgtttgcc 1130401 aacaaagaag agcttgtcgg cgagtactta aacacaaatc gtgacggctt ccttttggct 1130461 cataacatca gctcatattc tctgactgct gttgtcaaag cggcacgtcc gatgatgact 1130521 gaaggcggaa gcattgtcac tttgacgtac cttggcggag agcttgtgat gccaaactac 1130581 aacgtcatgg gtgtagcaaa agcttctctt gatgcaagtg tgaaatattt agctgctgac 1130641 ttaggaaaag aaaatatccg cgtcaacagc atttctgccg gcccgatcag aacattatct 1130701 gctaaaggca tcagcgattt caactctatc ttaaaagaca tcgaagagcg tgcaccgctt 1130761 cgccgcacga caacacctga agaagtgggc gatacagctg cgttcttgtt cagcgatatg 1130821 tcccgcggga ttacaggtga aaatcttcac gttgattctg gtttccatat cactgcccgc 1130881 taagcaggct gttaatgatg caagggctgt cttgctttct gtagcagggg atacaaaaat 1130941 cttgagcggt tggctgtttt gccgcgcctg ttagcagggc aagacaaata taaatgctgt 1131001 ttcgcccggg tcatggctac atataaaagg cgtctttcct cctcaagagc ggcctcgtct 1131061 ccttttcttg ccgtttctaa tgagaaatcg tgcggaatcg agccatctac agtgcctaac 1131121 acgtagactg ttttgaattc aaggcctttt gaccggtgaa tggtcatcag ctgaacgcca 1131181 tgttcatccg ttctgttttt ctcagcggcc ctcatatggt ctacgtgggc aagaaagtca 1131241 ggaatcgttt tgaacttctt ggcgacaacc ttgatgtcgc gcaggtcatc agagcctttt 1131301 tccagcttgt tgccctcatt gccccgcttt tttaaatact cggagaagcc catttttcct 1131361 tctgcaaagg tgatggcttc tacgggtttc attgtgcgga ggcttgcaaa aaacggtacg 1131421 attttcttga ttttgtccag ctggaatggc ttcagatcag gcaatttggc cagcgctttg 1131481 atcatggtac agtcctctgt aatcgagagc gccttcagcg tattcaaagc ggactgtttt 1131541 aaaaacaagg cgggaagcaa gtgtttaatc gcctcggtgt catcctcatt ttggctggcg 1131601 tacaagtagg cgagaatctg gcggacgatc cgtctgctgt aaaacgattg gacgccgcgg 1131661 tcagctgtat acggaattga cgattgatga agcctttcat atatagcacg gcctccgctg 1131721 tttgtgcggt aaagaaccgc aaagtcttct ggactggctc cattttgaat tttttctttg 1131781 atatcggaaa cgaccattgt ggcttcttcc tcttcatcat aaggataaaa cagcacaggg 1131841 acctgaatgt catcgcgggc cgcttcaagc gttttggcat atctgttttt gttctttttc 1131901 acaacgatat cagcactaga gacgatcggg tgcgtagacc tgtagttcgc agttaaatag 1131961 atcgtcttcg ctcccggata atccttttga aaatcaagaa tgaaagacgg attgcttccg 1132021 cgaaacgcgt agatggactg gtcatcgtct ccgacacagc acaggttttg ctccgggctg 1132081 gcgagcattt gcatgatttt gtattgaacc ggattaatgt cctgaaactc atcaattaag 1132141 atatacgtaa accgagattg atattgttcc agaaggtcag gccgctcgat aaacaattca 1132201 tagcaggctg aagccatgtc atcaaaatca aattggctgt gttctttttt ctggcgttca 1132261 taatgttcat ataaacgata aacttgtttt tcccactcat cttttagagg gatgcgttca 1132321 tttgggacat aagtgttttt ccaaaaaccg atctgctgca gggcttggtc aactggggat 1132381 tctttctcat cgatgccttc ttcatagagt gcttttttga tatattgttc ccgctgccac 1132441 tccattttca gcagatgctc accgttccat ttagcagaat tagagtgata caagatctta 1132501 taaaacagac tgtggaatgt tcctgtcaca attcttctga cttttgccgg ctgtaatccg 1132561 tactggttcg ccatacgctc tttcatttca gcgacagctt ttgttgtaaa ggtgacaagc 1132621 agcatatttt caggcggtat gcctaagtgt tcgatcatgt gggcggcacg ggctgtcagt 1132681 acccgtgttt ttccgctccc cgcacctgca agcacgagga gcgggccctc tgtttccgtg 1132741 acagctttca gctgatccgt gtttaaaccg acagacggaa aaaggctcgt atcgggttct 1132801 attgtttttg gcacaaatgg tgttcctggt ttaatgcttc taggacggtg ccattctgta 1132861 acagctgggg acgggtcagc ggcgatcgct tttcccttgg gtaaacgaat gacaccagat 1132921 tcctgatcat cttctttttt cccctcttta gagggcttcg gttcgcacgc ctcctcacat 1132981 gccggaaaat cgcctggctg gcgatggata aactctggcg gatcggcgat gttaagccgt 1133041 aacaaaacgg gctttccgca atgagaacaa aataaatgtc cttttattcc ctcttcaaag 1133101 aggaattgat aatgttctct cgaatatgta tgtaaatgta tgattctatc attcagtcgg 1133161 gcgcatttca aaaaggggtc ctcccaatca aaaggtgttc attacagaca atgactatca 1133221 tatcaaaaga aatgtgtttc aaaaagtaag tttaagggaa aagagacagc agaggggtgg 1133281 gtattgtatg atatatgcag gtcaaattca gaaccagcaa tacgctcaat atgctaatag 1133341 aacgattgga cataagcagg attatgccgg aaccgaaaaa atcagctatg tcccgtttca 1133401 gcgggtatac aaagaactgg aaaagcagca ggagaatcaa acggcagctg aaagaaaagt 1133461 aaacgagatg aaacgtaagc gctctcttta taagagattg cgagaaaaag gaatggggac 1133521 atatattaat cgatatgtat aaaaaaccgt tcataccaga gaacggtttt tttatatgca 1133581 gtaaaaatcc ggatctcaaa agatccggat gcgttcagtc cttcatcatt tgtaagtgcg 1133641 gaatgccggc atcgaggaat tctttttcag aaagcacgcg atacccgtgt ttcttgtaaa 1133701 acggcacagc ctgtgtttgc gcgtttaaaa tgaaaccgga agcgcctccg tctgccgcgg 1133761 ctttttcgag cgctttcata atgatgccgc cgacaccggc tgagcggtgg cttttcagta 1133821 cgcaaatccg ctctaacttg ccgtagccgt ccttcatgcg ccatcttccg gcaccgacag 1133881 gcttttcacc gtcatacacg acgatatgct ctgactcatt ttcaagttcg tcaatttctt 1133941 cttcagcagg cacgttttgt tctttgacaa agacttcttc tcttacatag aatgcatctt 1134001 tcagttgttc ttcatttttt gcgataactg ctttcaaaca ttattctcct ctgcctagca 1134061 agaaggtttc atatactgtc cacgatccgt tttccaactg gtagagcaag tggaaacggt 1134121 caacgatttc ttcatgcgac acttcctgca tttttaattg tcccagcaca tctgaatgct 1134181 catcgtcgga aagattttgg ccgaccgtca catgcggaac gaaattatat tcctgttctc 1134241 ctgccaacac accggtgtat agcttttcat tgagtgtttt taactcttcc gtcggttctg 1134301 ctttgatgta aatgacatta ttgacaggcg caaatgagct gtattttgtc attttgagaa 1134361 cgagtgggtg ggactctttt gcgatgtttc ttaaatgtga tacgagctga tccgctttct 1134421 cctccgcgca ttcaaaggat gctctcagcg tcaaatgagg cgggattaga gagtagcttg 1134481 ggtcatagcg ctttctgtaa gagtttgcaa ggtcttggag cttttttgat ggaaataaaa 1134541 cgattccgta tttcatatta tgtccctcct ggaaataaag tatgatagag tgttaaagca 1134601 tttttttcag cgccggggtg atgagcggct gccagtatgt ccatttgtgg tctccgtcaa 1134661 atggctcgaa atcataatcg gaaagctttt tctccagcag ctgtttcagc tcccggttcg 1134721 gttctgtaaa gtccagaatg ttcccgtctg tcgtgtggac gtcagtttct tttgttccga 1134781 tttggtgata aatagagagg tgtttgatat cgtctgactg ttttacggct tctagtacgt 1134841 gtttgtcaac atagggagac tgcatgatga tgttgccaaa catattcgga taatcaagcg 1134901 ctgtcataag tgacacggtt gctccgagcg aatcaccgat cagcgttcgg ccgtaaccga 1134961 tctgataggt tggatactca tcatctgcaa aaggaacgag ctcatgggcg atgaaccgtt 1135021 tataagccga aaattttgaa ccctccggat gataagtgtt tctgcgctct tttacatcct 1135081 tatagggaac accgataata atgctccggt ctatttcgcg tttcgacagc aattcctcaa 1135141 cctgtctgcc gattctcccc agcctgaaat aatcgtggcc gtcctgcgcg ataatgacat 1135201 ggtatttata aagcggggag tagttggacg gcagataaac aagcaaggtc atttcctcgt 1135261 taagctcttt tgaaaagaat ttcttttctt gcactgtgcc gtttttcggt gccataaaaa 1135321 cattcctcca ggacatcact atactttctt gcattttcaa ttattgtacc atgaattatt 1135381 agaaatttct ctctttaaac ggttcggcac acgaagaaaa aagtgttgaa ataaactgtg 1135441 aattgcgcta atataaaaca atcagaaaat tgaaatcgat atttcttatc gtgagaggtg 1135501 gagggactgg cccttagaaa cctcagcaac cggcttgttt tgcatttgca aagcgccaag 1135561 gtgctaaatc cagcaagcgt tttttatgct tggaagataa gaagaagcgt taaacccctt 1135621 cttcttatga agaaggggtt tttattttga aaagggaagg tgtcagctat atgtcacagc 1135681 acgttgaaac gaaattagct caaattggga accgtagcga tgaagtcacg ggaacagtga 1135741 gtgctcctat ctatttatca acagcatacc gccacagagg gatcggagaa tctaccggat 1135801 ttgattatgt ccgcacaaaa aatccgacac gccagcttgt tgaggacgcg atcgctaact 1135861 tagaaaacgg cgcgagaggg cttgccttta gttcgggaat ggctgctatc caaacgatta 1135921 tggcgctgtt taaaagcgga gatgaactga tcgtttcatc ggacctatat ggcggcacgt 1135981 accgtttatt tgaaaatgaa tggaaaaaat acggattgac ttttcattat gatgatttca 1136041 gcgatgagga ctgtttacgc tctaagatta cgccgaatac aaaagcggtg tttgtggaaa 1136101 cgccgacaaa ccccctcatg caggaggcgg acattgaaca tattgcccgg attacaaagg 1136161 agcacggtct tctgctgatc gtagataata cattttatac accggtcttg cagcggccgc 1136221 ttgagctggg agctgacatt gtcattcaca gcgcaaccaa gtatttaggc gggcataacg 1136281 atctgcttgc tggacttgtc gtggtgaagg atgagcggct cggagaggaa atgtttcagc 1136341 atcaaaatgc aatcggcgcc gtcctgccgc catttgattc gtggcttctg atgagaggaa 1136401 tgaagacgct gagcctcaga atgcgccagc atcaggcaaa cgcgcaggag cttgcggcgt 1136461 ttttagaaga gcaggaagaa atttcggatg tgctgtatcc cggaaaaggc ggcatgctgt 1136521 ccttccgtct gcaaaaagaa gaatgggtca atccgttttt aaaagcactg aagaccattt 1136581 gttttgcaga aagcctcggc ggggtggaaa gctttattac ataccctgcg acccagacgc 1136641 acatggatat tcctgaagag atccgcatcg caaacggggt gtgcaatcgg ttgctgcgct 1136701 tttctgtcgg tattgaacat gcggaagatt taaaagagga tctaaaacag gcattatgtc 1136761 aggtcaaaga gggagctgtt tcatttgagt aaacacaatt ggacgctgga aacccagctc 1136821 gtgcacaatc catttaaaac agacggcgga accggggcag tcagtgtacc gattcagcac 1136881 gcctcgactt ttcaccaatc ttcatttgaa gagttcgggg catatgatta cagccgctct 1136941 ggcacgccga caagaacagc tctcgaagaa acaattgccg cactggaagg cggaacaaga 1137001 ggatttgctt tcagttcagg catggctgcc atctcaacag catttttact gctgtcacag 1137061 ggtgatcacg ttcttgtgac agaagatgta tacggcggaa ccttccgtat ggtgacagag 1137121 gtgctgaccc ggtttggcat tgagcatacg tttgtcgaca tgacggatcg taatgaagtg 1137181 gcgcggagca tcaagccgaa cacaaaggtc atttatatgg agacgccatc aaatccgaca 1137241 cttgggatta cggatattaa agcagttgtt cagcttgcaa aagaaaacgg ctgcctgacc 1137301 tttctggaca atacattcat gacgccggca ctgcagcgtc cgcttgatct cggcgtggat 1137361 attgtacttc acagcgcgac aaaattctta agcggacaca gcgatgtgct ctcaggtttg 1137421 gctgctgtca aagatgaaga gcttgggaag cagctgtata agctacaaaa cgcgttcggc 1137481 gccgtccttg gcgtgcaaga ttgctggctt gtcctgcgcg gattaaaaac attgcaggtc 1137541 cgtttagaga aagcgagtca aacagctcag cggcttgcgg aatttttcca gaagcacccg 1137601 gcggtcaagc gcgtgtatta tccgggactg gctgatcatc ccggcgctga aacccataaa 1137661 agccagtcaa cgggagcggg cgccgtgcta tcttttgagc ttgaaagcaa agaggccgtt 1137721 aagaagttag tcgagaatgt gtcactccca gtcttcgctg tcagccttgg cgccgtggaa 1137781 tcgattttgt cctatccggc aacgatgtct catgcggcaa tgcctaagga agagcgtgaa 1137841 aaacgcggta tcactgatgg cctgctccgt ctgagtgtcg gcgtcgaaca tgcagacgat 1137901 ttagaacacg atttcgaaca agcgctgaaa gaaattgctc cagtttcggt tcgttaaaaa 1137961 agaagccggg gatagtccgg cttcttttat tattgttcgt catcaggatt cagaatcgcg 1138021 aggacttgat gatcctccca aacgccatta atttttacat tttttcgggc gatgccttct 1138081 ttatgaaatc ccgctttttc taaaacacgc atggacccga gattacgggg catcacaccg 1138141 gcttcaatcc gatgcagttt caattcgtgg aacgcataat caacaaccaa tctgactgcc 1138201 tctgtcataa tgccctttcc attatgggct ttgtctaaaa aatacccgat gaacgcagtt 1138261 tgcagcgcgc cacggatgat ttgaaagagc gaaaccgtcc cgattaatct atcgtctgac 1138321 gctgtaaaga tgccaaaatg atattcttca tctttctcaa gtctttcctg atactcggtt 1138381 attcgttttc tttgcccctc aaccgtatag taatcgtctg cgcgtatcat agaaaactgt 1138441 tcgaaaaaat ctcgattttc gctttgcagc cccagatttt cttcggcatc cgttacttct 1138501 aaaggtctaa cataaatggt ttttcctttt aacatatagt gatctctccg ttctcatgtc 1138561 agcattcctc ttacattatt ctcagggaaa tgcaaatatc ctttttataa gaaggaagaa 1138621 aaccaatttc ccataaaagt gccaacatag ttgccgatta agtagccgag cgtaccgaca 1138681 agcatgatcg gggcgacaag ctcccgccat cccttggcaa ttgccatcgc agccgcagtc 1138741 gtcggtcccc cgacagtagc gttgacggcg agcagaattt cttcaagccg cacacggaac 1138801 aattttccgg cagctaagga aaccgctaaa ttgctaatcg caatgataaa cacgaataat 1138861 agaataagag gcgcattcgt gacgattaag cggagatctg caggaatgcc gatcaccaca 1138921 aaaaacaaat aaatcaaaaa ggttccaagc tcctgagatc cattgagcct ttcaaaaaaa 1138981 cgcgggaaaa gaaaaatgat aagaacagtt aaagacgtaa gaaccaggta ctgatcgcca 1139041 agcgtaccgg tcagcagggg atgagaaaaa atgcttttaa aataaccgga aaccttcata 1139101 ctaaccgcaa caagcgcgaa agcggcaccg gcattaaaag cgatatcctt taaggaaata 1139161 tccttccgtt tccaatagct ttcagcactg tttccgctgt ttccatcggc ttttaccttc 1139221 tcttcaaacg gcatggcata atgccgctga aaccatttga gtgcaggaat gctgattaaa 1139281 ataaaaaaca aaagcgccat cataaaatta tcagccacaa cggtagccga cacatattca 1139341 ccaggcgtct caaattttgc cgccatcgcc gcaaagttga ccccgccgcc gatataagag 1139401 gcgctgatca tcccaccgat tttatctaag taaggaatat gctgtttgag tagaaaaaaa 1139461 gccaggatac tgccaagcac tgttccaacg gagctaatca gaaaaataaa cagcaaacgc 1139521 ctgctttcct taaaaatttg cctaacattg atctgaaaca ataaaagtgg tatcgccagc 1139581 ggtaccacat aagaccacac agtgtcatac acgggcgact caacaggaag cactcctaca 1139641 tttgtaaaca ccatagcacc tgcaagggcg ataatagcgc ccgacacagc agacgcccac 1139701 ttaaagcgct gctccagccc gatgctcact gccgcccaca ccgcaataaa cccccataat 1139761 acccatacat catcagaaga aatcaaagaa tgcaaaaccc catcacctct attgttagaa 1139821 aattaagaca tattataata gccggggaac ggaacagcaa gtccaaaaaa agtttttcta 1139881 aaaaagcagt tgacgaatag aaggtaaggt tatataatag aacttgtcag aaagataaca 1139941 acatacccag caacacatac atatcatgat tccgtagctc agctgggaga gcgctacctt 1140001 gacagggtag aggtcgctgg ttcgagccca gtcggaatca tagcttaaac ccttgcgcag 1140061 caagggtttt ttactttgcg ttaataaagc cggttcgtca aattcgtgag ttgttggcga 1140121 actgttggcg aaattcattg accgcagtcc aaaaactacc tccaaactta cttgattagt 1140181 tcaatagtaa caaacggaag atcggatttc tgttaaatct tcattgagaa tagccagtcc 1140241 aagaccgtca cttcagccat gcatctttta aatgaaattt tgtactgaaa acatcaattg 1140301 tatttttaaa ttctgctcta gaatcagccc ctttataata atcttgataa attgcttggg 1140361 gtgatactga ttcgtgattt gtgctatggt ttgcaaggct tgtagcaaaa gcaggagcaa 1140421 cagtaacgag taaagcaagg gataatgcaa aaccagttaa agctttttca atttcatttt 1140481 aagcacttct ttttttaaaa tacaacttta ttattaaatg gaatacaaaa acatccaagg 1140541 tgtttttttg ttagtaagtt gagttagggg gattggatgg cacttagaat attgtttctg 1140601 ctgatgggat gttgattctg gatatatttc caacacgatt acaggccgga catgaaagcg 1140661 aaccttgctt tgatcggggc aatcatttca tttacggctg cggtttactt taaagatatt 1140721 gatgtattga gagaagaggg aaaacaaatg aacggaattt ctgagcgttg gaacacgttt 1140781 aaattacaaa aatcccctga accactctag atcaggggat tgctttccca acagcttatt 1140841 aagtagcgga aggcatgatc aacgatttag tatcaattta ttaattgcga atactagaaa 1140901 cataccgttt tccgccttcc ttagaagtaa catattctcg aggaacatta agtctattgg 1140961 tagaatgata acttacataa agtttcatat ttgctcggct cgttacgata gccgtatgat 1141021 ccatccaacc atcagcatag cgaagaccta ttttattatg gtaatcatag tgatatacat 1141081 ctccaagctt tacatttgaa tatgtatcag aaacagtctt catttttatt ccgccagctt 1141141 ttaaaatgta tgatctaaag gctcctgcat taacccaagc atctgtatag ggtttccatt 1141201 ctttaaagta cggcattctt ccagctctta atgcttggga aacaaagtta gtacaatctt 1141261 tgtctttata atatttatag tttttatttg gttttaaggc atatttttct gcatatttca 1141321 ttgcagcgta accactatat cctttaacag atgttgcagt cacagttagt tgattagagt 1141381 tagcagcatt gaagttcata cttactggtt tatcttcact tttcacttct tctttatcat 1141441 catttttcac ttcttgctta tattttttta aaaattcatc taatttaaca tccgaagaat 1141501 attcttcatc attttcatat tgtagagttg aagaagaatt atttaattgt gttacattta 1141561 gttgcttaga agaattactc aatggtatta catttagttg attagaagaa tttttaactt 1141621 gagagaaact tagattagaa gtatttgttg attgagaact ttgtttatta gaagttgttt 1141681 tgggaatttc aagtttaata ttatcgccca gagatgttgt tactttttca acaccaaaaa 1141741 caaagtttcg agtaatataa gcttcaacaa ttagcttatt gtttttttca gaagtcttaa 1141801 catcgtctat atcgtatgta aactcgtgga atttttgttt gtccacttta cttaacgcag 1141861 aatacagtaa gactccttcg tcggaatcag tcaatttaga ctctttagga tgcgctaaag 1141921 gagtgttgtg ttcaaaatca tatttttgtt gttctaacat atccttaact ttttcgtaac 1141981 caatctcgtt ggtaattgaa acattttctt tagtctcttt attagtagtg gctgcaaaaa 1142041 cttcatttgt tgacactaat ggtgacaatg atagacataa aactagtgaa gcaagtaatt 1142101 cttttttcat acgaaacctc caataaaatc taaatataag taatatttat catttacacc 1142161 aattgaaata tggcataaaa tacatgtaat aatataacat aaaaataaat acataaaaag 1142221 gtatcggagg aaaaaatgaa aaagaaaact aaaattatac tttctctctt ggcagcactt 1142281 attgttatat tgatagtact tccagttcta tctcctgttg tctttacagc ttcttcggaa 1142341 aaaggagcaa tcagacacga aatttataaa agaggatatc cctaccaaag ctactttgca 1142401 gttctccaga aaagagaagg agacaatgaa tctgggaatc tttattatgt aaattggcta 1142461 gattggaaag atgaaacagg gcaaactcct cacttatgct attcgaaaaa atcatcagat 1142521 ggtgaatacg aagtaagttg tggcacaggg ccgtaaaaat aaattttaaa attgaataag 1142581 tccaagacgg aaagcctgcg gacactgatc gttttacaga gaaatttgtg cttcgatcgg 1142641 tgtccgtttt ttttcgcaac taaccagatg tctatcgcga ttactagcta tgaaaggagt 1142701 aattagacat gaaacagtcc aaaaagaaac catcacagaa gcaacatgag cgcttagatc 1142761 gtttctggca acaaatgatg aacactaaca tgcaaacact cagacgtggc aaaggcggcg 1142821 cttataaacg cagaaagtaa aaagggagtt tgaggatgat gaaaaacgga ttcgcttata 1142881 aaaacggaaa gcttgtgaat atcttttgcg gcaaagaaga gctctataac gagttgaaag 1142941 ccttcttggt caaaaccttc agtatcaacg tgaaagaggt atcgaggccc tcaatatatc 1143001 gcagaacaaa aagcaaacaa ctggaatgac acttactcta tttaactatc aggagggaaa 1143061 gcactatgac agatcaaatg attgcatggg agattgagga atggattcgt gattataaat 1143121 tcatgctgcg ggagatcaaa aggctcaacc gtgtattaaa caaagtggat tttattagca 1143181 caaagctcac tgcaacatac ggggaggaag cgggcatgcc aaggggatca gcaggcgtca 1143241 gtcaggcaga attgcggcag atggaccgaa gagaaaggcg gcttcacaaa tatgaatcta 1143301 ttgtgcatta cctggacaat gcaatggaac acattgaaga agaaaagcac cgaatcgttt 1143361 acgattgcat gatggaaggc atgagctaca ctgctattgc aaaccacctt gattgctccc 1143421 gggataccat cagaaagatc aaaacagcca taatcggcaa catcgtcaat aaagtcaaag 1143481 aagccaactt tctgcaatat ttgaattcgt ttaaatcggc ggtgtaaaat ggggggcagg 1143541 atcggcgcgg cggattattc ctgcgtcacc accaatttca tacaatgagt aaaacctccc 1143601 agtggtaagc gaggatcaac tcaactggga ggtcttacat agtgaatcgg tgataaaaca 1143661 gcagcagtat tgcgtacatg ttaatatccc cgacaaaata tgtttttttc aacagattcg 1143721 ttcgacaaat tttgcaaatt gttaatcgat aacttttcat tcccgatatt aaaaatggga 1143781 gtgaattgta aaatgaaaaa acagaaaaat aataaaaaga agaatattga aaagcgaaat 1143841 attgaaaagc gaaatattga agagaagaat aatgaggact tagaagaact ggaaaatgcg 1143901 atttatactt atcacaaaaa ggagctactt gctttctttc ttgaaaaaac tcgaattggt 1143961 catgataagg aagaatacaa aaggttccaa tctcttcttt ataagttgga tattgaatgt 1144021 ttagaatttg ctatatcgag attttctcat atagatatta tccatgatca ttcaaaatat 1144081 gttccagcct ttatcccttt atttgcagca tatctcacca tgttctttaa tttttatgaa 1144141 aaacattggg gagctttatc ttttgctgct ggtacaattg ctgctattgt ttggataatt 1144201 gcagtagaaa gaaaacatag aaatcaagca atttctatta tgaaaatatt tgaacaagtc 1144261 aaagagagaa aagtgaaaga cagatctaaa gactgaaagg agaaaatatg aataaggata 1144321 aattaaggta tgcaatctta aaagaaattt ttgaaggtaa tacccctttg tcagaaaacg 1144381 atattggagt tactgaagat caatttgatg atgctgtgaa ctttttaaaa cgcgaagggt 1144441 atatcattgg ggtccattat tcagatgata gacctcattt atacaaatta ggacctgaac 1144501 tgacagagaa aggtgaaaac tacttgaaag agaatggaac atggtctaag gcctataaga 1144561 ccattaaaga gattaaagat tggattaaat aataagagca tcctgcgggg tgcttttttt 1144621 gttccctgta aactgcttcc ggtaagtctc aggatagaca attggcggtt aacggcttga 1144681 gcacggtggt ggtttagagg gaatatcttt tccaaaacaa cacgaatcag aagggggcgg 1144741 cggtgaatgt agatggccga aaagcacatt caggcgtata aggattacgt caaaggcatg 1144801 aaatacaagg accttgccga gaaatacggg gtgtcagtga acaccattaa atcgtggaag 1144861 cagcggcatg gttgggaaag gaaaaagggt gcacccattg aaaaaagtgt gcacacaaaa 1144921 aaaggcgggc aaccgggcaa caaaaatgca ttagggaaca atggcggcgc accacagaag 1144981 aatcaaaatg ctgtgactca cggctttttc tctaaattct tgccagaaga gacgcttgaa 1145041 atcatggaag agattcagga gcgttcgcca gctgatatga tatgggatca gatacagatt 1145101 caatatgcgg ccattcttcg ggcgcaaaag atcatgttcg tttctgataa ggaagaaatg 1145161 atcaaagagc tgaaaaagaa aaggtccctc atatctgagg tcagcgaaat tgaagatggg 1145221 cttgtcatta gttttagtac gtggtttcgc tacagacttt acagtgaaac aaacacctaa 1145281 cacatttcac attgcttcag attgccttca aacttgataa tataacttct aaaccttcct 1145341 ataaaatgaa ggttttttat ttgatttcaa tttttaaatc ctttacatac agcgattgat 1145401 taactcgagc aatcaatgtc gcagttatat ttatttttca agaaaatgtt ataatgaaaa 1145461 gccataaaat gatgggaggg ggaatttcga tgcattacat aacggcatgt ttaaaaatca 1145521 tcagtgataa agaccttaat gagataatga aggaattcaa aaaacttgag gaagaaacga 1145581 acaaagaaga gggttgtatt acattccatg cttatccgct tgagccatca gaacgtaaaa 1145641 taatgctttg ggagatttgg gaaaacgaag aagctgtgaa aatccatttc acaaaaaaac 1145701 acacaataga cgttcaaaaa caagaattaa cggaagtaga atggttaatg aaaagcaatg 1145761 tgaatgattg aaaggctctt taaaaagaga cattcaatga cttagtatca gccacttgtg 1145821 actaagtagt aaattgttgt ccaactctta ttttttctat ttaatatttt ttgagacgaa 1145881 aatgtttttt taagctgatt ttaaaatgta ttcaaagtca gctctgtttg atttaatgga 1145941 ttatattatt tggatagctt gttaccatca taatggagat actccttata aattggaggt 1146001 taaaataatg agtcattctc aagaaaaaat tgcactaatt acaggagcaa gcagtcaagg 1146061 ggatattggt acggctattt gtcgtaagtt agcctcacag ggtatacata tcttctttac 1146121 tcactggaat tctgatacgg cctggataga agaatttcaa caagaaattt tacgtatggg 1146181 tgtccgctgt gaggcaatga aaattgattt atcagatgca catgctgcat tcacaataca 1146241 tgaaaaaatt tcagataaat taggatatcc ttccatcctt attaataatg cagctcattc 1146301 cgcaagtgat aattatgtat cgttagatgc taaatcactt gatgagcatt atgcggttaa 1146361 tatgagatcg aattttcttc tttgtgttga attcgcccgt cggtttaaaa aatctaattt 1146421 aatatcagga agaatcatca atatgacatc agggcaggat ttaggtcctt tgcctgggga 1146481 gttagcgtat gcagcaacta aaggagctat ttctgcattt actaggtcgt tatcacaaga 1146541 acttgcacca ttgggcatca ctgttaacgc cgtaaaccca ggtccaacag attctacatg 1146601 gatgacagat gaaataagaa attttctttc acctaaattt ccaatggggc gtattggcac 1146661 accagatgat gcagcacgaa tgattgcctt tcttgcaagt gatgaggctg aatggataac 1146721 tggacaaatt attcattcag aaggtggatt tattcggggc taagctaatg aaacacggta 1146781 tacaccaatg tatgatgtat tcccaaaact aaatctaaac ttgaagcgaa aataaggtcc 1146841 cttctctttt tagaggggga ccttatttta ttcatgcatg ttttgcatcc agaaaatctg 1146901 gcggataaag attaataaac cgttacatat acttttccga atactgcagt acctttaaac 1146961 aaagtaatcg tggctttccc ttttgattta gccgtcacta aaccattttg atcgacttca 1147021 gcaacttttt ggttatcagt ccaataacga gtagctgaat tatttttaac agaataggtt 1147081 tctccaactt ttagaggtaa attatagtct tgaatcttga taacatgtgt aggtgaaata 1147141 gaaatgttct ttacttcagt aggtgtggag tttatttcat gagctgaagc taccccgctg 1147201 accgacagag ctaacgcaga aatcgataaa gcagaaacaa ccgttttttt gaaattcatt 1147261 ttgaaacact cctttaaagt tttttgtctt gcactataac aattcaataa aagtaattat 1147321 tttccttgta aataaatgtt aataatatgt gaacgatcaa ttgatttgag ctaagaatat 1147381 tgtgtgccct gcacagagtt tgtatttatg atggaaaatt gctgagagag aatggccatc 1147441 cttaaaatgt taatagcaca catttgatgg gtattagttt gttgagcgtg tggaaatttt 1147501 gttacctgca ctttatcccc gaagatacca aatcactttt cttcatcatg ttcttacttt 1147561 cgtactcata cattagaaaa tcttcgttct aaataggtga agaattggag tatttttatg 1147621 aatttctgct gaatatacat tacatagcaa actcaaagag tataaaaatc gcttttttcc 1147681 ggaagcttcg gtaaaaaacg aaacttttgt ctctatgatt ttgttttata atgtaaacgg 1147741 tttcttatat agtatactta tactatcaat ttgctcaagt agatactgac aggaaggata 1147801 gaaaaacaga tggaatacat aaatacaaga caaaaagaga ttttgtatct gttgttatct 1147861 gaacctgatg actatttagt tgtgcaagat ttcgcagata gggtacagtg ttctgaaaaa 1147921 acaatccgga atgatttgaa agtgatcgag gattatctca atgagcattc tcatgcacag 1147981 cttattcgaa aaccagggtt gggcgtttat ttacatatag aagaacagga aaggacctgg 1148041 ctaagccaac aattacatac tgaacatttt tcttctaggc agcggagcga taaggaaaga 1148101 atgctgcaca ttgcttatga cttattaatg aatccgaagc ctgtttccgc aaaagacatt 1148161 gccgctcggc attttgtcaa tcgatcttcc attaaaaagg atttatacgc agtagaagag 1148221 tggctgaagc gttttgatct cacactggtt tctaggcagc ggcttggatt aaaggttgaa 1148281 gggaacgaaa gaaataaaag aaaggcattg gcaagaatat ctgatttgat tcacaataca 1148341 gcgtttacca gccaatttat taaaagtaag tttttacatt atgaagtaga ctttgtgacg 1148401 aaagaaatca aatcactaca aaaaaagcat tccctctatt tcacagacga aacgtttgaa 1148461 agtttgttgc tgcatacatt gttaatggtc cgccgcatca aaatgaagca gccgatttca 1148521 ttgtccccaa aagaaatggc ggcagtaaaa aagaagaaag aatatcaatg gacatttgct 1148581 tgtttacagc ggcttgaacc ggtttttgca attcgcttcc ctgaagaaga agccgtgtac 1148641 ttaacattac atatattggg cggtaaggtt cgttatccat tgcagacaga agagaacctt 1148701 gaaaatgctg tgcttcctaa ggttgtaggg catttaatca atcgtgtttc agagctgaaa 1148761 atgatggatt ttcacaagga tcaggatttg atcaatggtt tgaacattca tctcaatact 1148821 gtgctacaac ggctgagcta cgatctttct gtagcaaatc ctatgctcaa tgacatcaaa 1148881 aagatgtacc cttatttgtt ccacctcatc attgatgttt tggaagacat caatcaaact 1148941 tttgatcttc atattcctga ggaagaggca gcatatttga cattgcattt tcaggcagcg 1149001 atcgaacgga tgcagggcag cagcgagaca cataaaaagg cggttatcgt ctgccacatg 1149061 gggattggga tgtcacaatt gctgcggaca aaaattgaac ggaaatatca ccaaatcgct 1149121 gtaatggctt gtattgcaaa ggccgattta aaggattata tcaaaaagca tgaggatatt 1149181 gatcttgtca tatccaccat tgcgctggag aatataacgg ttccccatat tgttgtgtct 1149241 ccgcttttag agcctggcga agagaagaaa ttaagtgcgt ttatacgtca gctgggcgaa 1149301 tcacaccgcc aaaaacaaaa aacgtttcag atgctgaaca atacgactcc ttttttggtt 1149361 tttttgcagc aggaggcgga gcatcgctac aagttaatcg aacagctggc gacagctttg 1149421 tttgagaaag gctatgttga taaggactat gcggttcatg cggtgatgag ggaaaaaatg 1149481 tcggctacaa atattgggtc aggcattgcc attcctcatg caaacgctaa atttattaaa 1149541 caatcagcaa tcgcgattgc cacattaaag gagccgcttg aatggggaaa tgaaaaagtt 1149601 tcgctcgttt ttatgctggc tgtcaaacac gaggatcaaa ctatgacaaa gcagctgttt 1149661 agcgagcttt catatcttag cgagcagccg gccttcgtcc agaagctgac gaaagaaacc 1149721 aatgtcatga catttttatc tcatttggat tattaaaagc agggattatt ccttgctttt 1149781 tttgttcatg gcagggcttg agaaataaat ttgcgagtga agacgcctat tctccagcaa 1149841 tgatctaaat aaaataagag tttaatagtt ggagaagaaa tgttacactc ttttctgtat 1149901 atggtaaaga atgaaaaaac acgattcggt tggtagtccg gatgcatgat tgagaatgtc 1149961 agtaaccttc ccctcctcgg gatgtccatc attctttaat atcttttatg aggagggaat 1150021 cgttatgaaa ttaacgattt actacgatgg tcagttttgg gtaggcgttg ttgaagttgt 1150081 ggacaatgga aagctaagag cctttcgtca tctttttggc aaagagccga gggattctga 1150141 agtattagag tttgttcata accaactttt gaatatgatg gcccaagctg agcaggaagg 1150201 agtgcgttta caaggcaggc gtcaaaaaaa gatcaatcca aaaagattgc agcgccaggt 1150261 ttcaaaagag ttgaaaaacg ccggagtaac ttctaaagct caagaggcga taaagctaga 1150321 gcttgaagca agaaagcaaa agaaaaaaca aataatgaaa gaacaacgag aacatgtaaa 1150381 agagcaaagg tatatgctca aaaagcaaaa agcgaaaaag aagcacagag gtaaataatc 1150441 caaacaaaag caggcgcagt gcctgctttt gtaattaagg actctacttt gtaacatata 1150501 tccaatgttt atactccgct gatttatgat tcaatataaa ccctaacttc tccaaggttt 1150561 tttgtgagcc tagattatca tgttcgcatc ttgcggtgat ccgggatact gtttctcggc 1150621 ttaatgccca gtttattagt ttttgggcgg cttccacaca ataacctttg cggcgatgac 1150681 ttttatttgt tgcaaaaccg atttcaatca tgccattttc gtctgggtca cctaaaaatc 1150741 cagttccccc aacaatttca taattgtcct tctttacaat aatccatgaa tcaaatcctt 1150801 ttgttccatt gtttttgact aaaatctcgc ggaaataagg tatcgcttca aaaaaatcag 1150861 aatttggcca ttcaccattt gtttcatagc ctaattcttt gatagcctga tgatcttgtt 1150921 tagacgcggc gtcaagaagg ggaatatcaa tcgtttgtaa tcgtaatcga ttcgtttcaa 1150981 ggagaaccat atatttaatc ctcttttctt tttactggga ataatgataa catataacaa 1151041 ttttctctgg taccttggca gtagagaaag atgaaaaaat tgagggggat tgaaagagtg 1151101 acaggtgaga gtttgcccag accaaaaacg ggtaggaaaa tgctgatgtt aatgtgtccc 1151161 tacccgtttt tctgttcctg aatgcagggt ttctgataac atgttgtgct accttttcgc 1151221 aatcaaataa agcgatatgg ctctttgggt ttgcacagga ttatgaatga taatgaccca 1151281 ttggtttctt cgtcttggaa agcttgctac cgcatacaat ggagcagtat cgcgcggagt 1151341 gaacccacca tttatcacgt tgatatctct tccttcaaga tgacaaacta agtattcacc 1151401 tggattgatg acctgttggt tcgtccatgc gtaagaataa aagccgtctc caagatcttc 1151461 ggtggaagat ggggggacaa agccatctac agtcaatgtg atttctcttc ttcgctgtct 1151521 ttctgaaaag tctggacttc tttgagggtt atgagtatgt gaaaagtaag gaattaacgc 1151581 agggccataa aagtaatgat acaaagcaac cactccttta ttttccattc atacaaattg 1151641 tatgtgggag ttatttgttc attcctgttt tgttccatgt agactaataa tgggctatag 1151701 gcgtccaagg aaatcaattt gtccttccgt tgattcaatg ctagtaacct tgaaaatgca 1151761 ggttaggatg atagaattta catattactg caagaagtta gacatacatc attttgatag 1151821 tgggtgaaaa caatggcgaa aaaaatggca aaaacaaatg cggttcgtct gatagaacag 1151881 cagaacatct cttatgaggt attagggtat aaaacagacg gccagccggt agatggcatc 1151941 tctgttgcgg aaaaaatcgg ttattctttg aaatatgtat ataaaacgtt ggttgcagca 1152001 gcaggaacaa atcattatta tgtctttgtt gtacccgttg cagaagagtt agatgtaaaa 1152061 aaggcagcaa aggtgacagg ggaaaagaaa atagaaatga ttgcaatgaa ggagctgtta 1152121 gcggtaactg gctatcttcg cggcggctgc tcgccaattg gcatgaaaaa attgttcccg 1152181 acctatattg atgcatctgc agaaacgctt gattttatta ttgtcagtgc agggaaaatc 1152241 ggtatgcagc taaagttggc gccacaagat ttagccagat catgtgatgc cgcatttgca 1152301 gaaattgtat agatgcagat ataggggaac gaaaaagctt agtcatatcg attaagcttt 1152361 ttccgcatcc ctttcaaata tgatttcaaa ataagcagct gccccatacc catctatact 1152421 gggagcgaaa atctgaacga atctccagcc tcttttcgca taatcatgga tgatttgctg 1152481 gtagtcttct ttaggccttc ttctcatcgt actcagctca actcttacga attcatattc 1152541 tttcatcgtt tgatccctcc tattaaggta tacgtaaaat ggagcgagaa gttccgaaaa 1152601 cctaggttaa ggtcggaaag tatatttcac tcactaaaca aatccattta tgcctgatgc 1152661 ctgcatgcat ctgggaagag ttaaggggct ataaaaacga attttaccgg gtcagcagtc 1152721 caaatgaatc tcttgcttat tgcatttgac tgagtatata agtaaaaaaa gagcggccag 1152781 aacatataag aaggagatga tcattaacgc actcataaca gggtagtgtt tagcggagta 1152841 gatgaaaaaa tcaagctgtg aaatttgttt ggggctgctg acggcatcaa ttccattaag 1152901 cagttttgag agtttagcag tatagttcca atcaaatcga tctgaaacaa gctcgcttcc 1152961 ttgataccaa ttaacagcag ctaaaaacag aaataccata atagaaaatc caagctgaac 1153021 aactaaaaat attcccttca cttttgtatg acctccaaat ctatgaatat gggaaaatca 1153081 aacaatatat taccaccgta tgggttattc ttgcaatttc acttccatac aactcaaacg 1153141 caagtctatt tttttgtttg tttttggctt ataatacctg atgatggaaa aagagtgcgg 1153201 gtttatagat tagagaaaca aatgtatttc ttagcatttt ttatttgtgg agagagtata 1153261 gaagcattcg attagatctg ctttttcaca gaaacggttt tcatctgttt gcctgagctt 1153321 tacaattggc tggcaaaaaa acaatgattt ctttcaatca aaacatgcaa cgatgcgaca 1153381 cattttatat cttgatgact tatttcattg cctttaagtc atcctatcga gaaagcgatg 1153441 gtattttatg aacaaagaaa ccctaaaaaa catactcatg attttttcaa tatgcgcaac 1153501 actccgagaa accgatggta tgcgcatagc tgatagctgg attttgagtg agattatacg 1153561 atttttgatt tgcatggttg tgttttttgc catgacattt ctattagatg ctgtttttcc 1153621 aaacaaaaaa gagtcacatt aatgtgtggc tctttttgca tcatctgatc agaaacatca 1153681 taaatgaatc gatcatcatg atgaagaaca gcaagcaaaa ataaataagc gagtagacaa 1153741 acatatcctt tgcccacttc acgtcatcgt ctgttttgaa tcctttgatg ctttttttga 1153801 tccatatgcc tccgagaacc aaggcggcta agaaataaaa tgggcttata tggccggtgc 1153861 cgagagagaa aggaaataat agcgtgaccg gcaccaggac ggcaatatat tgcatcattt 1153921 ttatttttgt tacatgattg cctttgacta ctggcaagag cggaacgcca gcagcgcgat 1153981 attcctcttt gcgtcttatc ccaatcgccc aaaaatgcgg cggctgccac agaaacataa 1154041 tcgtgtacaa cagcactgct gtcatactga agtcaccggt tacggcacaa taccccatca 1154101 atggcggcgc agctcctggg aagctcccga caaatgtgct ccacacagac gttcgtttca 1154161 cccataccgt atagatgatc gcataaaaaa taaaggcggc cagtccgaga aaggccgtta 1154221 atggattgag ggaataaagc atggcaagac ctgcgattcc taaaacagag ccatatgtta 1154281 agatcatggc tggcggcatt ttccctgtga ccgaggccct gctgcgagtt cgtgccattt 1154341 ttgcgtccat atgccgatca aaatagttgt tatagacagt gccggaagcc atcacaaacg 1154401 cggttcccaa cattgctgtt accattgtca tcaaaaaagc caagccggtt aacgtttttt 1154461 ctgcgcttgc aaacgcgatc caaaacccgc cgaaggctgc tatcgagttt gatatgataa 1154521 tgcccggctt tgcaagtttg ataaaatcgt aaatggttac ccggttcgaa gcttttatgt 1154581 attttgtttc agatatggct gcagaatctc ttgtattctc caaaaataga cgcctccccc 1154641 aaaactgcat gcttttgtta tcgtaacaag agggggacag aatcacaatt atttcccata 1154701 tttgtcatga tattgtcatt tttaaaacaa aaaaatgggg agctggactg cccccatttt 1154761 gatatgtggc gactagtaac cgtaacctcc cccatatcct ccgccataac ctccgccgta 1154821 accgtaccaa gggtagtaag gcggtcgcgg gcgcgggtag taataaggcg ggcgcggata 1154881 aaacgggtag aacggataat acggtcttgg ataataataa ggcggataaa atggcggtct 1154941 cggacgcgga taataataag gctgtctttc atcataaggg gtaatttgtt caaatgactg 1155001 ttcattcaaa gggtaatcca agaggaaaac ctccctagct ttttttattc cttttaccat 1155061 attcctgatg cttaagttgg gtgtatgtac attcatgaaa ttcggttttt tttatgatga 1155121 aattccttaa aaaggattga catgaacttc taaatctcat agtattacaa atgtgaaata 1155181 aatgttacta caatgttaca aaaacatttc taaatagata cagttccaac tgatgaagag 1155241 taaatcgaaa tggctacgaa agaaggagtt tttgttgttg gcaaaaagaa tcaaatggtt 1155301 tcatgtatta atagcagttg tatgtgtggt gggccttatc ggctttttcc ataatcattc 1155361 attgaaaaaa gaaacggtca tgaataaagt aagaactgat tctcaatatg ggaatgttga 1155421 gatcgcaacg cttgtgaatg acgggaaaac ttttaattac gcggtaaact atcctgtttt 1155481 caaaaatgaa aaaatggatt cggcattaaa aagattcgca gaaaaagagg ttcgtcaatt 1155541 tcaaaaggaa acaaaggacg ttgaccaaga gcatacgaca aaacgcaacg aattaaatgt 1155601 tgattataaa attgtccatt atgccaaaca gacagtggcg attgtattta atgaatataa 1155661 atacatcggc ggggcacacg ggcaaaccgt gaaaaaaacg tttaactatg attttagtaa 1155721 acaagcgttt ctttccattg atgatatttt caaagaggac gctgactact tacataagct 1155781 ttcgttaatc gcttatcacg agctgaaaaa gaataaggac attgccgcgg acgatgcact 1155841 gttaaaggaa gggacggctc cgaaaaaaga aaatttcagc cgctttgcca tcaaggagga 1155901 ttatatcgaa ctttactttg acacatatca ggttgcagca ggctatcttg gagagcaatc 1155961 gattgccatt aagaaaagtc ttttgaaaga cattctgaaa gaacaatata ttgataaagc 1156021 aaaaaataaa aataaaatca aagaacaaaa gccgaagcat gaagtgattt ctttacccaa 1156081 agaggaaaca gttgatccaa atcaaaaagt cattgcgctt actttcgacg acggcccgaa 1156141 tcctgcgaca acaaatcaga ttctagactc cttgaagaaa tataagggtc atgccacgtt 1156201 ttttgttttg gggagcagag ttcaatatta tccggaaacg ctaataagaa tgctgaaaga 1156261 aggaaatgag gttgggaacc attcatggag ccatccgctt ctcacaaggc tttcagtgaa 1156321 agaagcgtta aagcagatca atgatacgca agacatcatt gaaaaaataa gcggatatcg 1156381 tccgacgctt gtaagacccc catacggcgg cattaatgat gaactgcgga gtcaaatgaa 1156441 aatggatgtt gcgttatggg atgttgaccc ggaagattgg aaagaccgta acaaaaaaac 1156501 aattgttgac cgtgtcatga atcaggcggg agatggaaga accattttga ttcacgatat 1156561 ttaccgcacc tctgctgatg cggccgatga aattataaaa aagctcaccg atcaaggcta 1156621 tcaattggtg acagtttctc agcttgaaga ggttaaaaaa caaagagaag cgaaataaat 1156681 tagaaaaggc tgtccgtacg gacagccttt tttctattta ataagagcct gtggtggccc 1156741 aaacatttaa gtttggtcct gaatacttgc cgaaagcgta agaagtcctt ggatctaaat 1156801 catataccat cggtgtatag caagactttt ggccggccac cgcttttcca ttgccgcctg 1156861 cagaatcaca attatatctt tttccgtctg tgttccgggt aatctccgca tttgcttcat 1156921 agccagacgt caatgtatta ttcatcgtga tttttgccca agccgtttta catgtactgc 1156981 tgaatttaag ctcgactact ccgatgactt gattgctggc attcactaag tttgaggatt 1157041 tttttgtaga gccgctggac gcacaatcat tgtaataagg gctttttcca tcgtaggcat 1157101 gggtttccgc cttggcgggt gcacctttga cggcaaaaac aaatactact gcgaataaca 1157161 ccaatgaagc cttcataaac agtcttttca atttatgacc tccttaatat ggcaaacaat 1157221 aaatcatatg gaggaacaat caaaacatgc atgctttttt gtgaacaata aaggcggccg 1157281 ggaggatgga gttcttggcc gcctctggta tgaggttatg cttttacatc aatggtttgt 1157341 ccgagagttg gatgttgaat catctttaag gtttgatcgg cattttgctg ggcggtgtcc 1157401 agcctttttt tcgttaaagc aatatttaca ttctgggcaa gggatgcttg atgcatcgca 1157461 accgataaag caggaatatc catggttcca cctcctatgc cttacctatc ggcgggtttg 1157521 tatgatttta cagtgaaaaa tggcttaatt tctcttgttg acccttacgc tgcggcatat 1157581 cgtatgtttt tgacaaggag ggaatcagga tgaatctagt aatggaaaag acctttgagc 1157641 aatacgaaaa gctgttttca atggaagaac agaaaagaga agatgtattt cggtatacga 1157701 tgatgaggcc gtttgaaaag atgtggaccg ccatccaagt tccgctgaaa gcgaaggagc 1157761 caaacggcta tgatgtgatc atggctgcga aaatgctggg ctatttggat gtccgtgatg 1157821 ctgaaagcgg ccagaaagca ctacaaatac tgaaagaatc acatgtttca gagacagctg 1157881 aatctgcact tcggcaatgc atattttttg ctgagcgcga acagctgcgg gtgaatgcaa 1157941 aggagatcaa attcggcctt tatatcgctg atccaaataa gcttcagctg caaaaaggct 1158001 actgcgggtt tggcgggata ccgggcttta ttcatgtatg gattaatccg aacagttata 1158061 acctgccaag gattccttcc attattgctc atgagtttca tcataatgtg cggttttcgt 1158121 atatagattt tcatcatggc tctgtaagtg tcggggatta tcttgtgatt gaaggattgg 1158181 cggaatcatt cgccagagag ctgtttggta cggaacgatt gggcccttgg gtaactcgtt 1158241 ttgatcatga agacttgcaa tattccattg atgtgattaa tgaggtgctg gatgtgaaag 1158301 gattttcgga agtcagccgt tatatgtttg gtgatccaat tgctaacgac caaggcttta 1158361 agcctgcagg tttatcggct tttgcgggtt atgcagttgg ctatcatgcc gttcagtcat 1158421 ttatgaatca acatcatatc acgataagcg aggccacacg tttggatgcg aagaccatta 1158481 tttctcaatg cggtctgttt tctacatgaa aaaagcgtca catacagcgg cgctttttga 1158541 ttcccaaaac cagcagttct atggcggcac aggcggcaat tccgattgta tatgcttcga 1158601 tatcgctcca taaaaaaccg taccctagta caagcccgcc aagagaagta tctctaatct 1158661 ggtcgatcca ttcggcatga tagagctggc tgaattcaat gacaaaacag aaagaaagac 1158721 tgataatgcc cgttatcatt gtcttcagct tccgaaatag aaatccgcat cccgtgaaga 1158781 tcatggcggc ccacaacgag tctcccagat aagtattgag ggtatcagga agaacactgg 1158841 agaatgctct ggatccaagc cccagcccaa tgatcagtat ggtgaaaact gcatatatcc 1158901 aacgatttcg cttcattgcg aattgatacc ccgtctctgc ttcatctccc tgtattgtaa 1158961 ggaatatagc ttttatttgt ccactaaaaa agcggctgaa tagccgcgta gggtgtttat 1159021 tttgctttta ggtttacatg gtcggctgtc tgatccgtgc ctattacaaa atggagttca 1159081 tagcggcctg tatcatatac ataatcgatt tcatcggtaa acgggacggt taacacccga 1159141 tttactggtc ctaattgctt ctgcagcact tccggcgtaa ctccgcctaa attcagctgc 1159201 cgttccacac cggttccaaa gtagcggatt tctgaaattg tcatgtcttt atgataggaa 1159261 aatccgtagc ccggctgtcc catattccag tgatataaat caaatcgatt gtctcccccg 1159321 actggtcttt ccggttcccc aaacgcagcg tggacatccc cttttgtgct tttgttaatg 1159381 gtaaggcctt gcgcctgctg aggcatttcc cctttatagg cggtgttata gaggtttttg 1159441 acaagctcag cggctgattg attcgtgttt tctgagagtg tgtttgtttg agctgcggcc 1159501 tttgccggtg ctgaaaagga cgcagcccca aagccggtaa aacagcttgt tactgctgct 1159561 gccgcggtta tagcagacat tgtctttttc atgttaatcc ctcctaattg atctaccatt 1159621 ccgtttcccc gtgtttttgc aacgaaacat gtgagtgcgc tttgtatgtt ttattgagtt 1159681 gttgtaaggg aactgaaata ggtaattcgg tatataaagc aagaaagggg aatggagatg 1159741 gctggcaaga aaacaatcac aataaacggc gttgaaatgg aagcgtccga ggaacagacg 1159801 gtgctgcagc ttttgaataa cagctcgatt gaagtgccgc aagtttgcta tcatccaagc 1159861 ttagggccga ttgagacatg tgatacgtgc atcgtcagca tcaatggtga gctgaagagg 1159921 tcgtgctccg ctgaattaaa ggatggggat gtcattgata cgctctcacc tgacgtgaaa 1159981 aaagcgcagg tcatcgggat ggacaagatt ttatataatc atgagcttta ttgtacagtt 1160041 tgcgattaca acaatggggg atgcgaaata cataatacgg tgaaggaaat gaaaatcaat 1160101 caccaaagca ttccgtttga tcacaagcca taccataagg atgaatccca tccgttttat 1160161 cggtatgatc cagatcaatg tatattgtgc ggacgctgtg ttgaggcatg ccaagacgtt 1160221 caggtaactg aaacgctgac cattgactgg gagcggaaac gcccgcgcgt catttgggat 1160281 aacgacgtgc cgatcaatga gtcgtcatgt gtgtcatgcg gccattgttc aacggtctgt 1160341 ccgtgcaacg cgatgatgga aaaaggaatg gaaggggaag ccggatattt aacaggcatc 1160401 aataacgaaa cgctgcgacc gatgatcgag atcacgaaag gcgtagagac aggctacggc 1160461 tcgattctcg cgatttctga tatggaatcg gccatgcgtg atgaacgaat caaaaaaacg 1160521 aaaaccgtct gcacgtattg cggcgtcggc tgcagctttg atgtctggac aaagggcaga 1160581 gacattctga aagtagagcc gcaggaggaa gcgcctgcca acggcatttc tacttgtgtg 1160641 aaaggcaagt tcggctggga tttcgttaac agcgaagaac gcctgacaaa gccgctgatc 1160701 cgtgaaggcg atcatttccg tgaagcagag tgggaggagg cgttattgct gatcgccagc 1160761 aagttcactg aattaaaaga ggcgtttggc ccggattctc tcgcttttat tacatcttct 1160821 aaatgtacaa atgaagaatc ctatcttatg caaaagctgg ccagaggggt cattggcaca 1160881 aataatgtgg acaactgctc tcgctattgc caatctcctg cgactgccgg cctgttccgg 1160941 acagtcggct atggcggtga ttcaggatca attacagata tcgcgcaagc ggaccttgtt 1161001 ttgattatcg gttcgaacac gtctgagtcg catccagtct tatccactcg gattaaacgg 1161061 gctcataagc tgagagggca gaaagtgatc gtcgcggata tcagaaagca cgaaatggca 1161121 gagcgctcag atttatttgt ccagccgcgt gccggatcgg atatcgtctg gctgaatgcg 1161181 atcgccaaat atttaataga aaacggcaag gccgatgaac gatttttgag agaaagagtg 1161241 aacggacggg atgaatatgt aaaaagcctc gcgccgtaca cacttgaata tgctgaggag 1161301 aaaaccggga ttgatcaaga aacccttatc caaatggcag agatgatcgg gcaagctgac 1161361 agtgtgtgcg cattgtgggc gatgggcgtg acacagcata ttggaggaag cgacacgagc 1161421 acggcgatct ctaatctgct gcttgtgaca ggaaactacg gaaaaccggg agcaggttct 1161481 tacccattgc gcggccataa caacgtgcag ggagcaagtg actttgggag tatgcctgac 1161541 agactaccgg gctatgaaaa agtgacggac gaacaagtcc gccaaaaata cgagcgtgtg 1161601 tggggtgtgc cgctgccgaa ggagccgggt atgaccaacc acgaaatgat tgaaaaaatc 1161661 cattccggac agttgaaagc gatgtatgta aaaggtgaag aaatgggcct tgtcgactcc 1161721 aatatcaatc atgtacacgc tgcatatgaa aagcttgatt tctttgtggt gcaggacatt 1161781 ttcctttcac gtacagcgga gtttgctgat gtggttcttc ctgcgagccc gagccttgaa 1161841 aaagaaggaa cgtttacaaa cacagaacgc cggattcagc gtttgtatca ggtatttgaa 1161901 ccgctgggtg aatcaaagcc ggattggcag attattatgg aggttgccaa taagcttggc 1161961 gccggctggc tctatgagca tcctgcagac attatggagg aagcagccaa gctgtcgccg 1162021 atttatgccg gtgtcaccta tgaacgtctt gagggctata attccctgca atggcctgta 1162081 aacgctgatg gaaaggattc gcctttactc tttacagagc gcttcccttt cccagacggc 1162141 aaggccattc tctaccctgt ccagtggaca gagcctaagg aattcggtga ggaatatgat 1162201 atccatgtca acaatgggcg gctcttggag cacttccacg aagggaacct gacttacaaa 1162261 tcaaaaggga tttcggagaa aacaccggaa gtgttcttag aaatttctcc tgagcttgcg 1162321 gcagaacgag ggattcagga cggaaccctc gtcagactca catcgccttt cggaaatgtc 1162381 aaagtgaagt gcctgattac tgatcgagtc aaagggaagg aagtatatct gccaatgaac 1162441 gattcagggg aagcggcgat caacctgtta acaggcagcc atgccgataa ggataccgat 1162501 acgcctgctt acaaagaaac atcggccaag atggaaattt tgaagcacga cggaatcagc 1162561 ccgctgccta agatcaacca ccgcaacggc aatccgcagc cgcaaatcgg tgtgcaggtt 1162621 cataagaaat gggcgcggaa ggattatatt ttccctggtg acgctgtgaa aagggggatg 1162681 ggccataatg gctaaagcga ttaaacgaat ccaaaaaatc gaggtaacag aagaggatca 1162741 gcgaaagcgt gatttgcggg aaattgaaga tgctctaatt gaccacaaag aagcgattct 1162801 cgaaacattg catatgctgg gccatatgaa cgagcgcggg gtcctgccgt tgctccgcgg 1162861 cctttttggt caaggggata aagttcttga tatcctggtg aaaaaggcag atacagagga 1162921 aacagccaat acgctgaaaa atctgcttct tctgtttgga acactcggca tgctggacgt 1162981 gaagcagctg gagcctctca ttttgaaagt gaatgcgggt gtggcaagcg ctgtagagca 1163041 gaaaaacagt gaagaaaaga caggttattt tgatattatc cgctcgctaa aagacccgga 1163101 aatcaacaaa tcaattacac tgctcttttc ctttttaaaa ggaatgggac aagatacaaa 1163161 ggagctggaa cgcacgacgc agcctccgga acaccaaaaa catcatcagg aaccccgaga 1163221 gaaaagagga atgaataagc gagattgacc tcccacccga gcggcttcag ccagctcggg 1163281 ttttttgatg aaaaggtcta atggactagt aaaaaatatt caaatactag gaagaagtaa 1163341 gattgtgatg aatgagatag aaataatcgt tactttctta cctgttaaga aaagggaaaa 1163401 tctgattata atagaaatcg attactttag atgggggaac aatcatgaaa aaagtcttat 1163461 tactattatt tgtcttgacg atcgggttag cgctttctgc gtgcagccaa tcgagcgatg 1163521 cgtcagagaa ggaaaaaccg aaagagaaaa aatcgcaaga agagcttgaa aaggaacttg 1163581 ataaggaatt gaaaaaaggc ggtgagccga agaccaaaaa agatgatcaa atacataaaa 1163641 taggagaaac atttaaagca ggacatacga attttacagt gaataaagtt gatagagtgc 1163701 aaaaaggtga atatatgaat gttggcggag ctgtaaatga ggagacaaaa acaataaaag 1163761 atgatgagga acggcttatt atagaagtta cgatggaaaa tataggggaa gattcaataa 1163821 gctacaattt tatcgggttt gatttaagag ataagaatga tcaatcagtg cggcctgttt 1163881 tttctataga agagaagggc agaatcctta tgggaggaac actagtatcg gggaaaaagg 1163941 ttacaggtgt actcagttat gtcatcccta aaggagaaca gaaacattac acactggtat 1164001 ataatccgtt tttagctgat acaaatagca gtaatacaga agagagagta aaggacgata 1164061 ttgattactt ggtgaagtta gattagatgc taatttacag ttgcacgttt ttcatctgtg 1164121 gaaaacgtgc attttttata gcgaaacttg acttgaaagg atgagtgata aaagtgcaaa 1164181 ccaaatggct ggaacgggca cagcggattc gggcgatcgc ccaagcgggg cttgcttttt 1164241 ccaaggatgt gtacgacagg gagaggtacg aagagctaat gaagcttagc gcggaaatga 1164301 tggcggatta ctcggagaag gacattgaag ttatcactga tttatggcaa ggcgagaagg 1164361 gctatccaac accgaaagcg gatgttcgcg gcgctgtatt cagagagaat cagattttgc 1164421 ttgtccggga gaagcatgat gagctgtggt cgctgccggg cggattttgc gagattggtt 1164481 tatcgccggc tgaaaacgtt gtcaaggaaa tcaaagaaga gtcggggtac gatacagagc 1164541 cgtctcgatt gctggccgtg ctagacagcc ataaacactc tcatccccct cagccttatc 1164601 actattataa aatcttcatc gcatgcagca tgacggacgg gcagggggaa acagggatcg 1164661 agacgaatca tgccgctttt tttccggaag acagactccc gccgctttct cctaaacgaa 1164721 acacaccctc acagcttagc atgctgtttg actttttgcg ccatccggac aagaaaacga 1164781 tatttgacta aaaaagaaag agcctgtggg ctctttcttt tttataatgt aatgtgtttt 1164841 tcgttggcga gtttcagaag ggtcaaaata gaatcggctt gtttatggcc gagtttttgc 1164901 tttaatttgt tttcttcaac taatcggctg ccataaattt tgacggaggc tttgtcgacg 1164961 acagtatgcc agttttcctg tttttttccc tcaacaagcg gtttttcatg tctctcagaa 1165021 aaagagaaca caaagagtac gaatgcaagt gaaagtagga ttccgacaac ttgttttttg 1165081 taatcagtct gtgctgccac gttgttctct ccttcacctt ttaccttcta tttaatcata 1165141 gaaccaaatt attttacata atgggaaagt catttttgga gttagtgcat ttggttgaaa 1165201 acagagacgt tttttgagcg gagcggtgca attgaatcca tattggattt gcgtgcttat 1165261 gcctaaggtc acgttgtgag ccaaaacagc agtgcagaat agaaaaaaat tgaaagatta 1165321 tggtaagatg aacgaaattc gagggggaat atatgatgcc tgcatcgaac atcgtgatcg 1165381 cctgcctgct gttatcaatt taattatttg tggtagtccc tctctttttc gaaagcggga 1165441 ggtgaagtgg aacattaatt gctgaattct ttcaagggga gtgaccgtac atgaatgtgt 1165501 taaaccgccg gcaagccttg cagcgagcgc tgctcaatgg gaaaaacaaa caggatgcgt 1165561 atcatccgtt tccatggtat gaatcgatga gaaaggatgc gcctgtttcc tttgatgaag 1165621 aaaaccaagt gtggagcgtt tttctttatg atgatgtcaa aaaagttgtt ggggataaag 1165681 agttgttttc cagttgcatg ccgcagcaga caagctctat tggaaattcc atcattaaca 1165741 tggacccgcc gaagcataca aaaatccgtt cagtcgtgaa caaagccttt actccgcgcg 1165801 tgatgaagca atgggaaccg agaattcaag aaatcacaga tgaactgatt caaaaatttc 1165861 aggggcgcag tgagtttgac cttgttcacg atttttcata cccgcttccg gttattgtga 1165921 tatctgagct gctgggagtg ccttcagcgc atatggaaca gtttaaagca tggtctgatc 1165981 ttctggtcag tacaccgaag gataaaagtg aagaagctga aaaagccttt ttggaagaac 1166041 gagataagtg tgaggaagaa ctggccgcgt tttttgccgg catcatagaa gaaaagcgaa 1166101 acaaaccgga acaggatatt atttctattt tagtggaagc ggaagaaaca ggcgagaagc 1166161 tgtccggtga agagctgatt ccgttttgca cgctgctgct ggtggccgga aatgaaacca 1166221 ctacaaacct gatttcaaat gcgatgtaca gcatattaga aacgccaggc gtttacgagg 1166281 aactgcgcag ccatcctgaa ctgatgcctc aggcagtgga ggaagccttg cgtttcagag 1166341 cgccggcccc ggttttgagg cgcattgcca agcgggatac ggagatcggg gggcacctga 1166401 ttaaagaagg tgatatggtt ttggcgtttg tggcatcggc aaatcgtgat gaagcaaagt 1166461 ttgacagacc gcacatgttt gatatccgcc gccatcccaa tccgcatatt gcgtttggcc 1166521 acggcatcca tttttgcctt ggggccccgc ttgcccgtct tgaagcaaat atcgcgttaa 1166581 cgtctttgat ttctgctttt cctcatatgg agtgcgtcag tatcactccg attgaaaaca 1166641 gtgtgatata cggattaaag agcttccgtg tgaaaatgta atagataagg agactggaga 1166701 ttcatgaaaa agtaccatat ttcgatgatc aatatcccgg cgtacggaca tgtcaatcct 1166761 acgcttgctt tagtagagaa gctttgtgag aaagggcacc gtgtcacgta cgcgacgact 1166821 gaggagtttg cgcccgctgt tcagcaagcc ggtggagaag cattgatcta tcatacatcc 1166881 ttgaatattg atcctaagca aatcagggag atgatggaaa agaatgacgc gcccctcagc 1166941 cttttgaaag aatcactcag cattctgccg cagcttgagg agttatataa ggatgatcag 1167001 cctgatctga tcatctatga ctttgttgcg ctggctggta aattgtttgc tgaaaagctt 1167061 aatgttccgg tcattaagct ctgttcgtca tatgcccaaa atgaatcctt tcagttagga 1167121 aatgaagaca tgctgaaaaa aataagagaa gcagaggctg aatttaaagc ctacttggag 1167181 caagagaagt tgccggctgt ttcatttgaa cagttagctg tgccggaagc attaaatatt 1167241 gtctttatgc cgaagtcttt tcagattcag catgagacgt tcgatgaccg tttctgtttt 1167301 gtcggcccct ctctcggaga acggaaggaa aaagaaagcc tgttgattga caaggatgat 1167361 cgcccgctta tgctgatttc tttgggtacg gcgtttaacg catggccgga attttacaag 1167421 atgtgcatca aggcatttcg ggattcttca tggcaagtga tcatgtcggt tgggaaaacg 1167481 attgatccag aaagcttgga ggatattcct gctaacttta ccattcgcca aagtgtgccg 1167541 cagcttgagg tgttagagaa agctgatttg ttcatctctc atggcgggat gaacagtacg 1167601 atggaagcga tgaacgcagg tgtgccgctt gtcgtcattc cgcaaatgta tgagcaggag 1167661 ctcactgcaa atcgggttga tgaattaggc cttggcgttt atttgccgaa agaggaagtg 1167721 actgtttcca gcctgcagga agcggttcag gctgtatcca gtgatcaaga gctgctcagc 1167781 cgcgtcaaga atatgcaaaa ggatgtaaaa gaagctggcg gagcggagcg tgcggcagct 1167841 gagattgaag cgtttatgaa aaaatccgct gtcccgcagt aaaaacataa aaaccgaaat 1167901 caatttgatt tcggttttct gtttaaatat tttttttcat cccgcatctc cggcattctc 1167961 taagaaattt tccgcctttt acagagcttt tgaacagtgt gtaatcacag ttgtcgcagc 1168021 gcccgctgcg ggcatccgga tattcattga attcgtaaac aatcgatgta tcgtagcctt 1168081 ttgtttcata ttcttctttt ttggtttcca tgtcgatcct ccgttacaag acgtgtctgc 1168141 tgtttatctt acagcaagct tccggcgtat tcaatggatt ttaggaggtt gggtttatct 1168201 tgatttctcc cttggtttgc gccaaaatag ctttattaag cttatataca taaaaagcct 1168261 atgcaaagag gagaggaaac gggtatggga aaagggttac ttggaaaacg cgtggcaatc 1168321 ggtggctcac gaaaaacgga agaaattagt acaatcattg aaaaacaggg cggaatacct 1168381 gtcatccggc ctctccaagg tacagtttac ttagcagaga agcaggtgga gccggatttg 1168441 cggacgtttg cggaagaaaa agctgactgg gtcattttca cgacaggcat cgggttggag 1168501 actcttgtcg atatggcaga gaaaattgga ctgaaagatg agtttctgca ggccattcgc 1168561 caagcgaaag cggcatgccg gggatacaaa acgctgtctg cgctgaaaaa gcttggaatc 1168621 acaccggaag cttcggatga agacgggaca acaagaggct taatccgttc cttggagcct 1168681 cacgactttt caggaaaaac agtcatggtg cagcttcatg gcgaaaaagc gccggctctc 1168741 atggcatttc ttgaagaaaa aggcgcgtct gtcctgccga ttctgcctta tcagcacatc 1168801 ccgccggagg aggaaacggt ggagcggtta tgccgagagc tgatgaacga tgaggtcgat 1168861 gccgtttgtt ttacaacggc cattcaggtt cgttccctgt ttgattttgc caaggggcga 1168921 ggttatatca atgaagtgaa gaaggtattc gaagaacgcg ccatcgcagc tgctgtcgga 1168981 aaagtgactg ctgaagcact gcgggaagag ggcattacga gactgcttgc gccagagatt 1169041 gagcggatgg gtgcgatgat tgttgagctg gccaagtatt atgaagaaaa ggaataacaa 1169101 gtacaaaaag ccgcttttcc ctcggaaagc ggcttttgtc tgtcattcat tttgcttcag 1169161 ctgctgatga acggtgaata atgatgggta tgtcagcacg cttaagatta cacaagtcag 1169221 cgcggctgag gccatcgttg taaacacgat taagagttga aagcgtactg cctgaatcgg 1169281 gtccgcgccg gctagaatct ggccagtcat catgccggga agctggacaa gacccagtgt 1169341 tttctggctt tcgagcgtcg ggatcatact cattttcatc gctgaggtaa gaatgcgctg 1169401 tatggattgc ttcggtgtgc cgccaagtga caatattaat tgaatttctt ctttgcgaac 1169461 gccgacttct gagttaagcc ggtttagaaa caaacttgag agcaccatcg aatttccgat 1169521 gaccatcccg ctgatcggaa tgacatatcg tgccgtaagc ggaatgatat gaagagacag 1169581 cagaattccc tgcgtcacaa tttctacgat tgctaacgcg gcaaacaccc tccaaaacga 1169641 accgatagta tttttctttc gcttgatgac attttgcgcc gccaccgcga gcattaacag 1169701 caccatcagc aggataaaaa cagggtggtc tccgcgaaaa atcagcgaca aaacataacc 1169761 gatgataagc agctgcaccg cggcccggat ggtggcgatg atcatgtctt tttctacacc 1169821 ggctttaaag gattttgata aaaacaaggc gatcaaaaca aagatcatcg ttaaagagag 1169881 agaaaggtaa tccattaccg agtgcctccc ttcaaaaatt ctttcgctgc ttcatgctgc 1169941 ggagcggaga aaaatgtgtc ggtttcagcg atttcaagca gccggccatc tgccataaac 1170001 caaatggtat cggctattcg ttttgcctgc tccatattat gagtgaccca catgactgtc 1170061 cattttttct cttgatgctg acgtttgatc agttcttcaa tctcaagagc agagaccggg 1170121 tccaaggccg atgtgatttc gtccaacaat agaatggagg aaggatttga gagcgttctg 1170181 gccagtgaca gtctttgccg ctgcccgccc gataagtctc tggcgcttct gtctaacaac 1170241 tctggcggca gccctgcaag cgaagccagc ttttcaggag agtacagctg ggattgatgc 1170301 agcctttgta caagacttaa attgtcacgc actgtcccgt cgagcacggg agccgattga 1170361 aacgcgaggg ctgccgttcg cctcagctca ttgacattcc attctctgac ttcctttccg 1170421 tatatgttga cttcgccgct gtcaggcgtt ctcattaaat tacacataga aaggagggtg 1170481 cttttgcctg agccggaagg gcctaaaacg gctacgattg caccctgttg aatgtctccg 1170541 gtgacatcct gcagcacatc ataggtttgt ccatcttgtt tatagctttt tctgactgat 1170601 ctgaaggaga tggctggtat gttttgtgtt tgatcgtttg cttccattac aataatcacc 1170661 tttcaatata agtaggctga cattatattt aactataacg tgaaacagat tccttttggt 1170721 agcacaaata aaggagaaca ggctttcacc cattctcctg cagatgctac gcagtcagat 1170781 ttgactgtgc tttctttttc ggttttctcg gctgtgaagc gaaggtatgt aacatcatcc 1170841 ccgctattat aatgaacaaa ccggcaaatg ataatagaga tgggaaaacg cctgacagca 1170901 gaacaatttc accaagcagc gcgaaaatca cttcaccgga ttgagtggct tcaacagctg 1170961 cgagtttttg cggattgtct cttaccatat cagtggccca gaaaaataaa accgtcgcaa 1171021 tgatgcctga gctgacggca acgataaagg attgaacggt ttgacttgct gttggaaggc 1171081 catctgacca ccagccgtaa gctgctaata taagccagaa tggaaggctt gccaatgtca 1171141 ttccaagcac gcgctgaaat gtatcaagcc ggcctccgta ttcttcgagc attcttcggt 1171201 ttcctaacgg ataggcaaaa gccgcaatga caaccggcag cacactgaaa agcagcatcc 1171261 tcccagaaag cgattctgca tgctgaagct gaatcagagc cgctccaatc aggatgatca 1171321 cagaagtgcc aagtgaaacc aggggaatct tttggcgaat gagctgcgga ccgcccggca 1171381 tatcttgttt gacataaaac aaaggagata agagcacccc ggctacaatt gtaatttgcc 1171441 aggttccagc tatgagccac cccggaccgt atgcagccgc aaatgtaatc ggtgcgtaaa 1171501 aaagcacgaa accgacgaag ctccatttga tccaataaaa cggctttttc ctcatttcta 1171561 gtaagagagg cgtgaatgtc cctctcatga tgacaatcaa acataaaaat ggcaccataa 1171621 aaataaagcg cagcgaagag ctccaaagcc agctgcctcc tgataactcc atcgctctgt 1171681 ttaatataaa ggtaacggcg aaaaagagtg aagccaatat tccgataacg atagctttca 1171741 tgatatccct cattctggca ttattttttt atactatact attcggtatc atgcagatca 1171801 atggaatcat gagaaaaaca tcatgtttgg cgaaccgcta tatgtggaag acaaaaaagg 1171861 gaggtgaaat tgatggaaag agagacacag acatacttct ttccggatga cggcaggatt 1171921 ccgaatcacc ctgattttcc gctcgtggtg tatcaaaacg cgcttaagga caccggactg 1171981 gcagagcgga tcgtcacccg gcatggctgg tcaaacagct ggtcagggag tgtttttcca 1172041 taccatcatt atcacagcaa tacgcatgaa gtcctgattg cccttaggag agaggctgtg 1172101 attcagtttg ggggagaaaa aggggctgcc atccctttca aatcaggcga cgcagtcgtg 1172161 attccagccg gagtcggaca taaaaagctc agctcaagcc ccgattttac tgtccttggc 1172221 gcctatcccg gtggcgttca gtacgatatg aagacgggga agccgaatga gcgggaggaa 1172281 gcggtcaaac agattaagca ggcggcgttg ccggcgaatg atccgatcac aggaaaaaga 1172341 gagcctctat tggaaatatg ggtaaagtga aggggagaaa ttgctggatt gtcaataact 1172401 agtgccgcag aaacgatatg acatgagctc catataaatt aatttcataa tcgaagcaat 1172461 tcacgttcaa attttgttca aaaagtgtta tcatatagaa ggtaatcgaa ttggagtttt 1172521 ttgtgtttgc tattttcaga gagagtaaag gattttgact tattcaattg tttattttta 1172581 gataaaaata atactgaata tggcaagatg aaaaactggg tagtaaacat ttatttttgt 1172641 aaatgattgt gcatgaattc acaatcctta ttcttatgcc ttaaaagcgt gagacaggga 1172701 gaggcactac cctttccaaa aaaatcagca aactgcttat agtaaaggag aattggatat 1172761 gccagaaaca atcgatcaaa caaatgcgtc tgtcagccaa agccagcaag atcttattga 1172821 tcagctatta aagccagaag ttcaagaatc attgactgtt ttagttgacc agcttccgaa 1172881 gctgactgag ttagtgaata ttttaacgaa gtcttatgat ttcgctcagt ctgtagcgac 1172941 tgacgaagtg ttaaagagcg acacagtcgg tgcgatcact gaaattctcg agcctgtaaa 1173001 agaaacagcg aaagaagtag ctgcgactgc gatcgaagca aaagaccgcg cggaagcaag 1173061 caacgaaaca attggacttt tcggccttct tcgcatgctg aaagatcctc aagctcaaaa 1173121 gctgttccgt tttgctaaca gctaccttga agtcatgaac gaacgcgaaa accaaaaata 1173181 atctcagatt caaattgata taaaggacgg aggatatacg atgtcaaaac atattgtcat 1173241 tctaggcgct ggttatggcg gagttctttc tgctctaaca gttcgcaaac attacacaaa 1173301 agaacaagca cgcgtgacag tggtaaacaa atacccaact caccaaatca ttacggaatt 1173361 acaccgcctt gctgcaggca acgtgtctga aaaagcggtt gcaatgccat tagaaaaact 1173421 tttcaaaggc aaagacattg atcttaaaat tgcggaagta agctctttct ctgttgataa 1173481 aaaagaagtt gcgcttgctg acggttctac attaacttac gatgcgcttg ttgtaggtct 1173541 tggttctgta acggcttact tcggcatccc aggtcttgaa gaaaacagca tggtattgaa 1173601 atctgctgcc gatgcgaaca aagtcttcca acatgttgaa gatcgtgtgc gcgagtactc 1173661 taaaacgaaa aacgaagcag atgcaacaat ccttatcggc ggaggcggct taacaggtgt 1173721 tgagcttgtt ggtgagcttg ctgacatcat gccgaacctt gcgaaaaaat acggcgtaga 1173781 ccataaagaa atcaaattga aacttgttga agcaggtccg aagatccttc ctgttcttcc 1173841 ggatgatctt atcgagcgtg cgactgcaag ccttgaaaaa cgcggcgttg agttcttaac 1173901 aggtcttcct gttacaaatg tagaaggaaa cgtaatcgat ctgaaagacg gatctaaagt 1173961 tgttgccaac acatttgttt ggactggcgg cgtacaaggt aacccattag tcggtgaatc 1174021 aggcctagaa gtgaaccgcg gacgcgcgac tgtaaatgac ttcctgcaat ctacatctca 1174081 tgaagatgta ttcgttgctg gagacagcgc agtttacttc ggtccagacg gccgtccata 1174141 cccgccaact gcacaaatcg catggcaaat gggtgagctg atcggttaca acctattcgc 1174201 ttacctagaa ggcaaaacgc ttgaaacatt caagccagta aactctggta cacttgcaag 1174261 ccttggacgc aaagacgcgg ttgccatcat tggtgctaat tctacaccgc ttaaaggtct 1174321 tcctgcttcc ttgatgaaag aagcaagtaa tgtacgatat ttgacacata ttaaaggact 1174381 tttcagcctg gcttactaat ccttttaatg aatctggcat tgccaaaagc attcctttcc 1174441 gagtgctttc tggcaatgtc tttttttatg tttatgacag cgttaacatt tcattttcaa 1174501 aaaagagatt gatcccaaag gaatataaag gtaaaataaa aacaaatcaa aatgttaacg 1174561 ttaacatttt gaaatagaat gaaagacggt gaggacatgg aacccttcat gggcaaaaac 1174621 tttttattga aaaatgaaac cgctgtcagc ctctatcaca attatgcgaa agacatgcca 1174681 attattgatt accactgcca cttaagtccg aaagaaatct atgaaaataa gacatttcaa 1174741 aacatcacgg aagcctggct gtatggtgac cattataaat ggcgcatcat gagagccaat 1174801 ggaattgagg agacatacat taccggagat gcgcctgatg aggagaaatt tatggcttgg 1174861 gcgaaaaccg tgccgatggc gattggcaac ccgctctaca actggactca cttagaattg 1174921 cagcgttttt ttggcattta cgagatttta aacgagaagt ccgggtcggc tatatggaaa 1174981 cagacaaata aactgctcaa aggggaaggc ttcggggcaa gggatttaat cgtgaaatca 1175041 aatgtaaagg tcgtgtgcac cacagatgac cctgttgatt ctcttgaata ccatttattg 1175101 ttaaaagaag acaaagactt tcctgtcagt gtgctgcctg gatttcggcc ggataaagga 1175161 cttgagatca atcgtgaagg ctttcctgag tgggtgcagg cgcttgaaga tgccgctgcc 1175221 atatcgatta caacctatga tgagttttta aaggcgttgg aaaaacgagt gcgattcttc 1175281 cactcagccg gcggcagagt ttctgatcac gcgatagata caatggtatt tgccgaaaca 1175341 acaaaagaag aagctggacg gattttttct gacagattac aaggaacaga ggtttcttgt 1175401 gaagatgaga agaaatttaa gacatatacg cttcagtttc tttgcggttt gtatgcggag 1175461 ctcgattggg cgatgcagtt tcatatcaac gctttaagaa acacgaatac aaaaatgatg 1175521 aaaaggctcg gacctgatac agggtatgat tcaatgaacg atgaagaaat tgctaagcct 1175581 ttatacaagc tgctgaactc agttgagatg aagaaccagc tgccgaaaac gattttatat 1175641 tcactgaatc caaatgataa ctatgtcatc gccagcatga tcaacagttt tcaggacggt 1175701 attaccccgg gaaaaataca attcggcaca gcctggtggt ttaacgatac taaagacgga 1175761 atgctcgacc aaatgaaagc gttatcaaat gttggccttt tcagccgttt tatcggcatg 1175821 ctcaccgatt ccagaagctt tctttcgtat acgcgccacg aatatttcag gcggatcgtc 1175881 tgcaatttga ttggagaatg ggtggaaaac ggcgaagtgc cgcgcgatat ggagcttctg 1175941 ggaagcatcg ttcaggggat ttgctatgac aatgcgaaac actactttca atttcaagaa 1176001 gagaaagcaa acgtgtaaca aagtgtccgc tcagtatcgc tgagcggatc actatccgaa 1176061 aattcttaag acacagaggt ggaacatgcg aactgaactg gcaaataagg ttgtgtcggt 1176121 cgaaacggaa aaaaggcttt cattgaaaga gaaaatgtcc tatggctttg gtgattttgg 1176181 caacggtttt atgtttgatc tcggccagat ttatttattg aagtatttca ctgatgtagc 1176241 gggaatcccc gctgcgatgg ccggcggcat ttttttagtc agtaagctgt ttgcagcgat 1176301 aacagatcca attgtcggct catcaatcga ttatcgcaaa aacatcggca aacgggggaa 1176361 attcaggcct tatctattaa tcggcagcat cgtgcttgcg gtgcttactg ttcttatttt 1176421 tctgtctccc aatgtatcaa cgaccggaaa actgatatat gcatatgcat cctatatgat 1176481 ttggggcatc ggctattcgt ttgtgaatat tccgtacggc tcattagggg cagcgatgac 1176541 tcaaaattct gaggaccgga cctccatttc gacgttccgc caaatcggat cacttggcgc 1176601 cttgtttatc acaagtgtgg ccgtgatgcc gctgctcgtc aagtttgata atccgaaggt 1176661 cggctacccg gtggtcatgg gcttgttcgc cgcgctcggt gtgttttggt tttatatttg 1176721 ctaccgcaac tgcaaagagc gcattatcat atcggaagca cccaaagaaa aattaacact 1176781 ctcatctgtc gtcaaaacat ttattacaaa taaaccgctg ttaacccttg tcctgatgac 1176841 gattttttca atttccgcat acaacattaa atccgccatg ctcgtctatt tcgcacaata 1176901 taacttgggc aatgttgaat taatggctta tatgaacttc atcattattg gttcttcctt 1176961 tttgggcgtc gtattccttc caaagctcgt caagatgttt ggaaagaaac gaacggcaat 1177021 gatcggcttt ggcatcagtg tggccgcgga tctgatcaac tttatgcttc catctaacgt 1177081 ttatgtgttt acaattctcg ccagtatcgc ctttatcgga atcagtatcc caaatggcat 1177141 cacgtgggct cttgtctccg atattatcga ctatggcgaa tggaaatccg gtgaacggaa 1177201 ggaagcaacg acatattcac ttttcaattt ctcaagaaag cttgctcaat ctttgtctgg 1177261 ctttctctcg gggatcggtt tggggattat cggctatgtg ccgaatgcag tccagacagc 1177321 acaggcgctg attggcatca aagcgctgct tcttctgtat ccggccattg ctttggcatt 1177381 agcgatgttc attatcggct ttctttataa actcacagac cagcagcatg ctcagatcgt 1177441 tcaggatctt catcaaaaga gctgacaata taatataaag aatatttaaa ataatttgta 1177501 aataaaatgt gtttgtaggg gtttcgcttg gagagtgccc aaaaaactga aaaggaagga 1177561 ggcacttgct tgaaaacgat aacaattgca gctgaagaag caaaggaact cgtttggcaa 1177621 aagctggacg gtgccggttt gaatgaacga gatgctgaaa aagtggcaga tgttctcgtg 1177681 cacgctgatt tgcgcaatgt acattcgcat ggcgtgctgc acacagaaca ctatgtgaac 1177741 aggcttttag cgggagggat caatcctggg gcacagcctg tttttaaaga gacggggcct 1177801 gtgaccgggg tgcttgacgg agacgatggt ttcggtcatg tgaattgcga catggcgatg 1177861 gaccatgcaa ttgacatggc gaagaaaaaa ggagtcggca tggtcacggc cgtaaacagc 1177921 agccattgcg gagcgctaag ctattttgtg caaaaagcgg ctgacgaaaa gctgatcgga 1177981 atggcaatga cgcatacaga cagtatcgtt gtcccatttg gggggaggac tcctatttta 1178041 gggacaaatc cgattgctta cggagttccg gctaagcata aaaaaccgtt tatcctagat 1178101 atggcgacat ccaaagtggc ttttgggaag attctgcagg cccgtgaaga gggcaaagaa 1178161 attcctgaag gatggggagt cgatgaaaac ggagaagcag taactgatcc tgacaaggtc 1178221 gtctcacttt caacattcgg gggcccgaaa ggctatggac tatcgattgt agtggatgtg 1178281 ttttccggat tgctggcggg cgcggctttt ggccctcata ttgccaaaat gtacaacggc 1178341 cttgatcaaa aaagaaagct ggggcattac gtttgcgcga tcaatccatc cttttttact 1178401 gactgggata cgtttttaga gcagatggat gccatgattg atgaactgca gcaatcaccg 1178461 ccggctgttg gattcgaaag agtgtatgtg cccggcgaga tcgagcagct gcatgaagaa 1178521 agaaataaga aaaacggaat ttctatcgcc cggagcgtgt atgaattctt aaaaagcagg 1178581 tgagtaaaat gaaagcggtt caagtgcgaa aagcgtatga tctggtgaca gcggaggtga 1178641 agaagccagt tctttcaaag gatgatgaag tgctcgtgaa agtcaagcga gtcggcattt 1178701 gcggttcaga catgcacatt tatcatggaa cgaatccgct cgctaccctc ccgagagtca 1178761 tcggacacga ggtaacggga caagtggagg cagttggtgc gaatgtacag agcctaaaac 1178821 ccggtgatca tgtggtgatt gagccgattt cttattgcgg atcgtgctat gcctgccgca 1178881 aagggcggcc gaatgtttgc gccaagcttt ctgtatttgg cgtacatgag gacggaggca 1178941 tgcgggaata tattgtgctt ccggaaagac agcttcacgc ggtctcaaag gacttgcctt 1179001 gggaggaagc agtcatggcc gagccttata cgataggcgc ccaggcagtg tggagaggcc 1179061 aggtggaaaa aggtgatacc gtcctgatcc agggagcggg gcccatcggg atctgtgtgt 1179121 taaaaatggc aaaactggcg ggcgctgctg tcatgatgac tgacttgaac aacgagcggc 1179181 tggcatttgc gaaagaaaac ggcgccgatg ctgttgtaaa tgtccaagca gaacatgttg 1179241 ccgagcgggt ccttgaatgg actgggaatg aaggagcaaa cgtggtcatt gatgctgttt 1179301 gcctgccgga gacttttgca ctttcaattg aggctgtgtc accggcggga catgtggttg 1179361 tgcttggatt tgatgaaaga gcggctcaga tttctcagct gccaattaca aaaaaagaag 1179421 tcacgataac cggatcccga ttgcagacca atcagtttcc aaaagtggta gagcttttga 1179481 atggaggccg gttaatgcat aacgggctgg tgacccatac attttcagtt gatgacgttc 1179541 atcatgcatt tcagtttatt aaggagcatc cagatcaggt gcggaaagcc gtcatcacgt 1179601 ttgattaaat gactgaatcc ggaggtgcga gcatgaatat gacattccga tggtatggac 1179661 gaggcaacga tacagtcaca cttgaatacg tgaagcaaat tcccggtgtc aaaggcatcg 1179721 tttgggctct ccatcaaaag cccgtcggcg acgtgtggga aaaagaagaa atcagagccg 1179781 aaactgaata tattcaatcc tatggttttc atgctgaagt tgtagaaagc gtgaatgttc 1179841 acgaagcgat taaacttggg aacgaagaac gcggccggta tattgaaaac tacaagcaaa 1179901 cgatccgcaa ccttgccgga tttggcgtga aagtgatctg ctataatttt atgccggttt 1179961 ttgattggac acgcacggac atgttccggc cgctagaaga tggatcgacc gctctgtttt 1180021 ttgaaaaggc caaggtggaa agccttgatc ctcaagagct gattcggacg gtggaggaag 1180081 catccgacat gacactgccg gggtgggagc ccgaaaaatt ggctcggatc aaagagcttt 1180141 ttgctgccta cagaacggtc gatgaagaaa agctatggga caatttatca ttctttttgc 1180201 aggaaattct tcctgttgct gaggcctatg gtgttcaaat ggccattcat ccggatgacc 1180261 cgccgtggcc gattttcgga ctgccgcgca ttatcacagg agaggcaagc tataagaaac 1180321 tgcgggcgat atcagattca ccgtctaatt gtatcaccct ttgtacaggt tcaatgggag 1180381 ccaatcccgc taacgacatg gtggagatcg ctaaaacgta tgccggcatc gctccatttt 1180441 cacatattcg caatgtgaaa atttatgaga atggcgattt tattgaaaca tctcatttaa 1180501 caaaggatgg ttcgatcaac attcaaggcg tgatggaaga actgcataag caggattacg 1180561 aaggatatgt cagaccggat catgggcgcc atctttgggg cgagcaatgc cgcccgggat 1180621 atggcttata cgatcgggca cttggcatca tgtatttgaa cgggctgtgg gacgcttatg 1180681 aagcaatggc aaaaaaagag gtgggcatat gatcccgctg catgagaacc tggctggtaa 1180741 aacggctgtc atcactggcg gcagcggcgt gctttgctct gcgatggccc gggagctagc 1180801 ccgtcatggc atgaaggtgg cgattttgaa tcggacggct gaaaaaggcc aagcggtcgt 1180861 gaaggagata acggcggctg gcggcacagc gtgcgctgtt gctgcggatg tgctggacag 1180921 gatgtcactg gagcgggcaa aggaagacat ccttggccaa tttggcgctg ttgatctgtt 1180981 aattaacggg gctggcggca atcatcctga cgcgataacc gatgtggaga catatgaaga 1181041 agcgggagaa ggccaatcct tttttgatat ggatgagagg ggctttctaa ctgtattctc 1181101 caccaacttc accggtgcgt ttctggcctc gcaagtgttt ggtaaagaac tgctgaaggc 1181161 ggattcaccc gcgatcatca acctttcttc catgagtgct tattcaccta tgacgaaggt 1181221 tccggcatac agtgctgcga aagcatccat caataatttt acgatgtgga tggctgttca 1181281 ttttgccgaa accgggctgc gggtcaatgc gattgcccca ggcttctttc tgacaaaaca 1181341 aaatcatgat ctgctgatca accaagacgg aacgttcacc agccgatctc acaaaattat 1181401 tgcgggaaca ccgatgaagc gcttcggaaa accggaggat ttgctcggta cgctcctttg 1181461 gctggcggat gaatcctatt ccggttttgt cactgggatc accgttcctg tcgatggagg 1181521 atttatggct tattcaggtg tgtaacgaaa gcggtgcaac agaaactgaa ccaacatagg 1181581 ggtgaggttg agatgttttc aaaagataag cttcccgtta tccttttttt gttcctggca 1181641 ggggtgatta attacctgga tcgctcggcg ctttccattg cagctccttt tattcaggat 1181701 gatctcacat tgtctgccac acaaatgggc ttgattttca gcagtttttc gataggttat 1181761 gccattttta attttcttgg gggcgtggca tccgaccgct atggggcaaa gctgaccttg 1181821 tttgtcgcga tggttgtttg gtcgctgttt agcggagcag tcgccctcgc ttttggcttt 1181881 gtcagcctgc tgattatacg cattctcttc ggaatgggag aaggcccgct ttcggcgacc 1181941 atcaacaaga tggtgaacaa ctggttcccg ccgacccagc gggcgtccgt tatcggtgta 1182001 accaacagcg gcacgcccct cgggggagcc atttccggcc cgatagtcgg catgatcgca 1182061 gtggcgttca gctggaaggt atccttcgtt ctcattatga ttattggatt gatatgggca 1182121 gtgctctggt tcaagtttgt caaagaaaag ccgcaagaga cgatcaagga agcaccggca 1182181 ataaaagcag aaacgtctcc cggagaaaaa attccgctca ccttttacct gaagcaaaaa 1182241 acagtcctgt tcacggcgtt cgcttttttc gcttacaact acatcctctt cttctttttg 1182301 acatggtttc cgagctatct tgtcgacgag cggggattaa gtgttgaatc gatgagtgtc 1182361 atcacggtca taccgtggat tttaggattt atcgggctgg ctgcgggggg atttgtttct 1182421 gactatgtgt acaaaaaaac ggcccgaaaa ggtgtgctgt tctcgcgcaa ggttgtgctt 1182481 gtcacgtgtt tgttttcatc agctgtcctg attggttttg ccgggcttgt ggcaacgact 1182541 gcgggggctg tcactcttgt cgctctgtca gtgttctttc tttatttgac cggtgctatc 1182601 tattgggctg tcattcaaga tgtggttgat caaaacaatg tcggttctgt tggcggcttc 1182661 atgcatttcc tcgccaacac ggcaggaatt atcggcccgg ctttaaccgg atttattgtt 1182721 gaccaaacag gcacgttttc tggagcattt ttgcttgccg gtgggctggc tgtcttcgct 1182781 tcacttgctg tgattcgttt tgtccgtcca atcattggta agccagcggg aacagaagct 1182841 gagaatcctg tgtcttatta atctggaaat atagtgggag aggcggtatg tttgatgata 1182901 caatatacag taaataatcg cagccggtat gataaggaag ggaattagat ggtaaccata 1182961 aaagatatcg caaaactcgc aaacgtatcc cacactactg tttccagagc actcaacaac 1183021 agcccttaca tcaaagaaca tacgaagaaa aaaatattag agctagcaga gcagctcaac 1183081 tatacaccaa atgtaaatgc gaaaagtctg gcgatgcaaa agtcgcatac gatcgggcta 1183141 ttctttacaa gcattacaaa cggaacctca cacagcttct ttgcagacac tatcaaaggc 1183201 gtcaatcaag ccataagtga ggattacaat ctgtatgtgc gcggcattga tgatctgaaa 1183261 aactatgact ccgttacacc gatgagatat gacggcatca ttttaatgag ccaaagtgac 1183321 attgataatt cttttattta ccatattcgc gaaaaaaaca ttccgcttgt cgtgctgaat 1183381 cgtgatattg atgatcgtac catcacgaat attttgtcca atgacaagga aggctctcaa 1183441 gaagctgtag aatacttcat tcagtccgga catcaagaca tcgccatcat cgaggggatc 1183501 gaaggcttta aatcctccca gcagcgaaag gaagggtact tatccgcact gattcaacat 1183561 catattccga tcaagcatga atacagtgtc aaaggacagt acgatatgga aagcggcttt 1183621 caagcgatgg agcggctgct ggcactgccg aatcctccaa ccgctgtttt ttgttcgaat 1183681 gatgacatgg caatcggagc gatgaatgcg atattcgcaa agggcctgcg cgttcctgat 1183741 gatatttcgg tgatcgggtt tgatgatatt gggttttcac agtacatcac gccaaggctt 1183801 tcaacagtaa agcgcccagt ggagaaaata agcgtgctcg gtgcgcaaaa actcttgtcg 1183861 ctgatcagcg agcccgaaac aaaagcagaa aaaatcttgg aaaacacaga atttatggtg 1183921 cgtgattcag tcagacgatt gacgacgtga tgtcccgttt ttcagcgggc attctttata 1183981 cagaaaaatg ttaacgtgtg cataaagtga gagggaggca ataagggtgc agaagctgaa 1184041 taaaaatgtg tacgatcact atactcagta tccagaaaaa attctccaat tcggagaagg 1184101 aaactttctt cggggattta tcgattggca gattgatcaa ttgaatcaac acactgattt 1184161 taatgggagc gtggcagttg tccagccaag aggctcagaa aaaatcaaac gattaaatga 1184221 gcaagatgga ttatatacac tttttttaca aggaatgaaa gacggagaag cggtaaacga 1184281 gcatatgatt atcaactcaa tcagccgggg aattgacctg ttttctgatt atgaagcata 1184341 caaagaattg gcatcaagcg aaaggcttcg gtttattatc tccaacacca ctgaggctgg 1184401 gattgtatgt gatgaaaaag atcgtttaga ggataggccg caaaaaacat tccctgggaa 1184461 attaactgca tttctttact ttcgctatca ggcttttaaa ggagatcaga caaaagggtg 1184521 tgtcctgatc ccatgtgaac tgatcgagaa taacggtgaa aagctgaggg aaacggttct 1184581 tcattatgca catctgtgga agctggagga aggatttaca cagtggattc atgaggccaa 1184641 tacattttgt aatagtttag tagaccggat tgttccgggt tttcccgtcg acagcattga 1184701 tgagatcacg gcagatcttg gctatcagga tgatttgata gttgtgggag agcaatatta 1184761 tttgtgggtt atcgaggggc ctgattggat tggaaaagaa cttccctttg cggctgcagg 1184821 gctgcataca aagatcgtca gcgacctcac cccataccgg actaaaaaag taagaatttt 1184881 aaatggcgct catacagcaa tgacgccagt ggctttatta tacggcttga agactgttag 1184941 ggatgcagtc gagcatccgg aagtggggcg atttataaga gagctgattg atgacgaaat 1185001 tcttcctgtt ttaaaaatgg aaggtctttc tcagtatgct gacgatgtgc tgaaccgttt 1185061 taaaaacccg tatattaagc attacctgga aagcattgca ttgaacgcca tttccaaatt 1185121 caaaacgaga aacctgccga ctcttaagga atatgctgaa caaaagggac agcttcctga 1185181 acgcttggtg ttttctttca gcgctcttct gtatttttat catgataacg agacattgca 1185241 ggatgatccg gcagttcttc aatttttcaa agaggtttgg tgtcaggagg atggcgacat 1185301 gcttcggatt gcatcaagag tgttaggcga acagcggctg tggggggcag atctcaatga 1185361 gataccgaag ctgactgata gagtcgctgt ttacttgaat catattcatg agctgggcat 1185421 gcagagggct cttgaacaat actgcataca agggggagag gtacgttgaa gtcgtttata 1185481 aagattcata agcaagataa tgtccttctt gctctgcggg atattcaaaa gggagagagg 1185541 ctgcatgctt acggcgtgtc gattgaagta aaggatgata taaaaagagg ccataagatt 1185601 gcattgcagt ctatcaaaga aaacgacagc atcgtcaagt acgggtttcc aatcggtcat 1185661 gcatcacaag atatctcgat cggagagcat attcatgtcc ataatacgaa aacaaacctg 1185721 tctgatatcc aattatacag ctatacaccg agatttgatg aaaatccgta ttctaatgag 1185781 aaccggacgt ttaaaggttt tagaagagaa aacggagatg cgggtgtacg gaatgaattg 1185841 tggattgtcc caactgtcgg ctgtgtcaat ggaatagcag aaaaaatgct gcagcgtttt 1185901 gtcagagaaa caggggatat cgctccattt gataacgtac tggtgttaaa gcatcaatac 1185961 ggatgctcgc agcttggcga cgatcatgaa aatacgaagc agatcctgct gaatgccatt 1186021 cgccatccaa atgccggcgg cgtcttggtg ttagggcttg gctgtgaaaa caatgagctg 1186081 gcaagaatga aggaagcact gcaagatgtg aacttgaagc gggtgaagtt tctggaatcc 1186141 cagtcggtga ccgacgaaat ggaggcaggc gttgctttgc tgaaggaaat tcatgaagcg 1186201 gccaaaggag ataagagaga agacattccg ctgtctgaac tgaagatcgg gctgaaatgc 1186261 ggaggttcgg acggtttttc cggcataacc gcaaacccgc tgcttggacg tttttcagat 1186321 tatctcattg cacagggagg gagtactgtg ctgacggaag taccggaaat gttcggcgca 1186381 gaaaccatcc tgatgcagcg ggctgccaat gaagaagtgt ttcataagat agtcgattta 1186441 atcaatgatt tcaaacaata ctttattaaa catgatcagc cggtgtacga aaatccttca 1186501 ccgggcaaca aagcgggcgg catttctaca cttgaggata aatcgctggg ctgtacgcaa 1186561 aaagcgggga tttctcctgt cacggatgtc ttgaaatacg gtgaagtact caagacaaaa 1186621 gggctgactc ttttgagcgc accgggcaat gatttgatcg cctcctccgc attggcggct 1186681 gccggctgcc aaattgtcct ctttacaacg ggaagaggca cgccgtttgg cacctttgtc 1186741 ccgacggtga aagtagcgac aaacaccgag ctgtatgagg cgaagccgca ttggattgat 1186801 tttaacgcag gccttttagc agaggatgat gttcatgagg aatatgtgct gcgtgagttt 1186861 atccactata tgattgaggt ggcaagcggc cagcttgtga accatgaaaa aaatgatttc 1186921 aaagaactcg ccatttttaa atcgggtgtg acgttataat aagaaaaggc tatccttcaa 1186981 gcggatagcc ttcttcatta aatcaatttt aaaccgctga ctaaaataat ggaagccata 1187041 ataaattgca gtggacgcgg ggagaatcga ggcgaaagat ggctcccgat cagtacgccg 1187101 ggaattgaac cgaggagcag attagctgcc agcatgtaat ccacgcttcc gaagcttgcg 1187161 ttcaaaatgc ctgctgccgt aacaagaaga aaagcatgcg cgatatcggt tccgacaatc 1187221 tgtgacgctt tcatgttaaa taagtaaatc atggcgattg caaataatga gccggacccg 1187281 attgatgtta atccgacgat aaacccaaac acaacaccaa taagaattgt cagcgccctc 1187341 ttattttcaa gcggcatcag ctgccagcgg ttggggcgaa gttttctatc caaaaacaaa 1187401 cgaacgatga ttgaaatggc aaccagcgtt aacacatatc ctagagcgtg cttaataatt 1187461 tcttcctgat gctggtgaaa ggcggggaac aaatgcaata tgccaatggc tagcgaagca 1187521 ctcggaatac cgccgatggc taagtatttt accaatttaa agttaatcgt tttctgccgc 1187581 caatgggagg caacgccaaa cagctttgtg atcgagttat atacaagatc cgtaccgacc 1187641 gcgatggaag gattaattcc aagcacaatt aaaaggggag ttaataaggc cgctccaccc 1187701 actcccgtca atccgactaa ggctccgaca aacaaaccca tcaatatgat gcttacactc 1187761 atgataaagg cctcctgaaa acccgactag aattcacccg aatcttattc gcgttggtca 1187821 agtattaatt gtaagtgctc catcggctgc tgaaaaaccc gagctctatc cgctccctga 1187881 tggtatcatt caattgacaa caccttatac atcaggagaa cacgtctttc aggtgcaacg 1187941 agcacttgcg gctctgtatt tttaccctga taaaggcgct gttaacaacg gaattgacgg 1188001 cgtttacgga ccgaaaacag ctgacgcagt tgcccgtttt cagtctgtta acggtctaac 1188061 tgctgacggt atctacgggc ctgcgacgaa agagaagatc gcagcgcaat taagctgatc 1188121 aaagaccata aaaatcccgg agccgctccg ggatttattt tttcttcttc aactttttta 1188181 taattccagc actgcgctcc ctcacccgaa gcgagtaccc ggaaagccca aaccttccgt 1188241 aatcaacaaa cttcacacgc ctcaccaatt ttttcactgt atcacctgac attatcctct 1188301 gtttgtattt attatatgtc accctttaag aaaaggaata aggacaagag ctgttttccc 1188361 ttgtcctttt agtgtgatca tgcttttttt cgtttatact cgtcaatcag ccgttcgttt 1188421 tctttgaaga ttcttgctgt atgcggactg acttgatagc ttgcgacact ggtggttgaa 1188481 cgttttttca ggattttaaa cggcttcgcc gctctgggct cgcatctgtt ttgaaacgca 1188541 cgttccatta tccttcacct tcctcctcaa ttggcagcac caaatcatat atgctcgtta 1188601 atgacgtaaa tagcaaataa tcaaattccg tgacaatgct gtcagacgtc agcttgatga 1188661 catagttctg tgtctcgatg gtaaaaggga tgagaaccac ttttccgtat tggtcgtaat 1188721 aaacatcctt tcgatcgagc cgtgtttgta catctgccgg atcatccata tgctcggtta 1188781 accggtcttt atcagcctgt gtcgaatagt ggcaaagaga agccgttaag ttcattttat 1188841 cagcataggt tttcagcagc ttatcaatac cttcagcata agcatctata cttccataat 1188901 aaacatggat cggttcgttt ttcaataggt attggtatgt tttcagccga ttgagataca 1188961 tgtggagcat ttcgttgttt tcttcaagaa tttctcttgt gtctgtttca agctcgctgc 1189021 cggccagttt tttgacatat gcacttaaga agataaaagc atcaatcaaa gcaaaactga 1189081 ctgcgacaat gagataccgt tcccagtggg taaataggga agtgggctca tatgtccagt 1189141 ataccatagc gcccagaaca aacagcaaat accaagtttt ccgaatggcg gacatttttt 1189201 ctttgacctt cgcttcgaaa cgccacgtgg catacacgta taaccccagt ccggccacga 1189261 tgcaccagac catgatctga aagaataaaa ccatattcga atccctcaca tctgaaatag 1189321 gttctgctta ttgtattcga gagatccgga tggttttcct gttccatcaa aaaaaccgct 1189381 cctttgacag aagcggtgtg acattaaaat atcatattta aaataaagta ggcgatggca 1189441 ccaagtgtcg ctgaaatcgg aagcgtgatg acccatgtaa tgagcattcg cttggccgta 1189501 ccccagttta cgccttttac gcggtgggac gcaccgacgc caagaattga tgaagaaatg 1189561 acgtgggttg tactgaccgg caaatgaata aacgtggcgc cgaaaataat ggctgctccg 1189621 gttaagtcag cggaaacacc gtttaccgga cggattttca tgatctttcc gccaacggtt 1189681 ttgatgattt tccagccgcc gattgatgtt ccgagaccca tggctgtcgc gcaggcgaat 1189741 tgcacccagg taggaatatc attagcagaa gtatgtaaat tcgctgtgat gagagccatt 1189801 gtgataattc ccattgcttt ttgcgcatcg tttgttccgt gtgtatacga ttgcagggca 1189861 gctgttacaa tctgcactct gcggaattgc ttattcgttt tcgccaagtt gctgtctttg 1189921 aaaatcagct taacgatgct ataaagaata aaaccaagga caaaggcaat aattggtgat 1189981 agaatcagtg cttcaatgat tttaatgaag cccttatagt ttaacgctgc aaatccggct 1190041 gccgcaatgg ctgcaccggc aatagcgccg atgatggcat gggatgagct gcttgggata 1190101 ccgtagtacc atgtgataag gttccaggca attgcagcga gtagcgcagc caaaatgaca 1190161 acagagccat tttccagcgt ataaggatct acgatgtctt tcgtaatggt tttggcaaca 1190221 cctgtaaacg tcattgctcc gacaaagttc atcacagcag ccaatataat ggcatggcgc 1190281 ggttttaacg cttttgttga taccgaagtc gcaattgcgt ttgccgtatc atgaaacccg 1190341 ttgatgaaat caaacgccag agcacaaatg actattagta tcgttaatat taatagaata 1190401 tccattttta cccctcgtta cgcgtttttc ataatgatgg tttcaagatt attggcaaca 1190461 ctttgacaag agtcggcgat ttcttcaagc gtttcgtata tttcacgata ttgaatgact 1190521 ttgattggat ctgtttcatt tccgaaaaga ttctttaatg attttctgtg caagttgtca 1190581 caactgtgct catactcttt aattttgatt gcgtgaggct gaatatcctt taagcgattt 1190641 tctgccagca gctcgatcgt aatcaaaatc tctttcgcac attctctgat atatccgctg 1190701 aatttatcaa tatgctcgtc tgatgaagta attgagaaaa tctccatcat ggcagagaaa 1190761 tgttcgattc cgtcaagcac atcatccaag ctgtttgtca gctgaaggat atcttcgcgc 1190821 tcaataggag tgatgaacgc tttgttaagc tctttaatca tgacatgaac atgattgtca 1190881 ccttttgttt catattcctt taacgtatct gcaaattctt taagagtcgt ttggttagtg 1190941 accttaaaat tcacaaaata ttctgcagtt tcgtctatgt tctttgcaat ttctgttaaa 1191001 aggagtgaga acttatcttt ttttcttctt atcattaaaa accctccata gtttgaatga 1191061 acaatgcaca catcaaatta ttatatagcc ttttgtcgaa aaaaaacagg taaagtcgaa 1191121 aaaaacgtat cttgactttt ttgataaatc gtgtctcctt attttgacct acttcgcttt 1191181 aaaaaaacga cccaagtttg caaaaacttt ctgcttaacg taaaaagtat atcaaaagtt 1191241 gtgtttttcc tgtcaacttt tatcttctgt ttcaccaaaa aacggttccc taaacaaggg 1191301 aaccgtttta tcagcttgct tttcgttttt tcatcccgta ataaacaggc agtccggcaa 1191361 ggccgatgag gatggataat ccgcagctca ttgtatctgt aatgagtgtg ctgcctaaca 1191421 caaagaagga gcccgcgatt gccagaattg gcataaatgg ataaagcgga acactgtagg 1191481 cgcgcttttc tccctttgct cgcttgcgga gaataaacac tgcaaaaaag gccatcacat 1191541 aaaaaatgta gatcatgaaa atggagattt ctgagagctt atcagggttg ctgatcagca 1191601 tcataatcaa agccaaagca atttgaaaag aaatcgcaat ccatggtgtg cggaacgacg 1191661 ggtgtacatg tgacagtttt tcagcaaatg gaagctgttt gcgttccgcc attgcaaatg 1191721 aaacacgcgg gaaagaaagc acctttccat ttaagcaccc aaagatgctg acgataatcc 1191781 ctacactgat cagctttccg ccaattgaac cgaacagcat ggttgcagcg gtgcttgtcg 1191841 cattttcacc aagcgtgaca atttcgttcg ctgacaggat gtgaagcaat gcaaaattaa 1191901 tgaaaatata gatcgccgtt acaattaata atccgcccgt catagcgcgt ggcagcagct 1191961 tttcgggatt tttcatttct ccgccgagag cggcaaggag aatccatccg tcataagcaa 1192021 acaacgtagc taaaatagcc gccccgaagt tcatatcaga aatgctttcg tttactgctg 1192081 tgaagatgtg ctgatcgcct ttccaaaggc caaagacgat gatgcaggca atcggaatca 1192141 gttttccgat cgttgtcagc gtttggacaa aaccgccgta ttttgtaccg ataatattaa 1192201 tgacgcataa aaagagaact gctataattc caatgacttt tgatagtcca gatccccagc 1192261 cgaaaagatt cgccattaaa gatccaaaat ataaacccag cgcgccaata atcgccgggc 1192321 cgtaaatgat aatctgcacc cagccgcaca aaaatcccca aaactcgccg tacacttctt 1192381 caaggtacgt ataaagcccg ccggtttttg gaatctgcgt tccgatttcc gcgattgtca 1192441 aaccgcccgc cagtgttaaa ataccgccta acagccaggc gaaaagcgcc atttttgaat 1192501 cacctgaata agcaagcaca gcgccgggct tcataaaaac accagaaccg ataatggttc 1192561 cgatgacaag agtaagggca aacaagaggc ctatctcttt tttcaaaccg ttgtcttcag 1192621 tatgcatgtc cttaacctcc tatgatgttg aagcttcatg ttgaagaatc tattttttca 1192681 tattgtaaac cctattttag aaaagtgaaa taaaataaat tttctgattt tcgaaatttg 1192741 ctttgtgtac agcagataaa actgtagaaa tacctgtttt aatggtctat aaacgaataa 1192801 aattcataat ttttatttac aaagttcgtg ttttatgtat taggatttta gccggtacag 1192861 aggggagatg agaattcaga aaatgaacga accttcggtg aagctgatat gttgactttc 1192921 tcatgcgaat aaaatacttt gttattagaa caataaatat acaattatga tatgatatct 1192981 cgaaatcgag ataaaataac ctggagggac agcatatgaa agttaacggc attcaccacg 1193041 tatcggcatt aacggccgac gcacaaaaaa acttggattt ctataagaaa gtattaggat 1193101 taaagctcgt caaaaaatcc gtcaatcagg atgaaccgac aatgtaccat ctgttctacg 1193161 gagatgaagt ggcaaacccg ggaactgagc tgacgttttt cgagattccc cgcattgcac 1193221 cgtttcatgc gggaacaaac agtatttctt ctattggatt gcgcgttcca ggcacagaag 1193281 ccctgcatta ctggaaagaa cgttttgaag agcagcaagt aacgcacagc ggcatctcca 1193341 aaagagccgg acgtgacata ttggcatttc aagatcatga ggggcagcga cttgtgctga 1193401 ctgctgatga ggaaggaaaa ggatatggcc tgcctgttaa acagagcggc attccggaag 1193461 aattttcgtt tcgcgggtta gggccggttg aactgactgt gccatatgct gaaccaactt 1193521 tacacgtatt gacgaatatt cttggattta cagaaatcag ccgtgaacca gtcgaagggc 1193581 aaggaaccgc cgttattctg gaatcaggag aaggcggtgc tgcaacggaa atccatttaa 1193641 tagaaagaaa cgatcttccg cgagagcgtc aaggcaaagg gagtgttcac cacgtcgcat 1193701 ttcgggtaag agatgaagaa gaacttgccg ggtggcaccg gatcatcagc cgcgaaggct 1193761 ttagcaattc aggcatagtt gagcgctact atttcaaggc gctgtatttc agagaaccga 1193821 acggcatttt gttcgagtta tcaacagacg gaccgggctt tatggtagat gaaaatcttg 1193881 atgagcttgg ccaaacgatt gctcttccgc catatctaga gcatcgaaga gcagaaattg 1193941 aagcaaaatt gaaaccgatc caataaattg tgattctttt gccttccggc gccgccggag 1194001 ggcttttttt attaccataa ttaattttga cctaaacagc atgccttatt agggaggaaa 1194061 tatcagatgc tgattgggag aaatggctta aaaccctttg caaatatggg tgattggtat 1194121 ggaatggcct cggcaaaaat attgtctttg tttattaata gtttattcat atttgcttgt 1194181 tacactattt caaagttaga caaaaaggag tgaaaaataa gtggaaaaga aaaaacgcga 1194241 gctggatatc gtcctcctcc tcattttgct cgcatctgca ttcttaaata tctataacat 1194301 ttggaaggac gacacggtga atccttatta caccgcggca gttacaagta tgatgcaaag 1194361 ctttcataat ttcttttatg cttcgttcga tgctgccggc tttataacag tagataaacc 1194421 gcctgttaca taccaaatcc aaacgatcag cgcactgata ttcggtatgc acggctggag 1194481 cgtcatcctg cctcaggcac ttgctggtgt aggttctgtc cttcttatgt acttgctgat 1194541 aaagccgaca tttggaaaaa cggcggcgcg tattgcctca tttgttatgg catgtacgcc 1194601 gatagctgta gctgtagcac gtacaaacaa tgttgatgca ttactggtat ttttcttatt 1194661 gcttgctaca tggcttctct ttaaagcgat cagaaaagga aagctgatct ggctgttagc 1194721 agcatttttc gttgttggag taggttttaa tacaaaaatg ctgcaggctt acatgatttt 1194781 accggctttc ttattgttct atctgattgc ggcaaacgcc acaatcaaga aaaaaatcgt 1194841 ttcattggta agtgcgttag ccgtattagc agccgtttcg ttatcgtggc cgctcattgt 1194901 tgacaatatc cctgcaagca agcggcctta tatcggaagc agccaaacca actctgtttt 1194961 ggaattggct ttcggctata acggaatcca gcggctgaca ggccaaaatt caggcggcgg 1195021 ccagggtgcg ccaaacaaag acgcttcaaa agaaatgtct tcttctgata acactcaagc 1195081 accgcctaat cagtcatcaa gcaacagctc atcaagcgat ggtaaatcct caaatggcaa 1195141 tatggcggcg cctccatcca atggccaaat gccaagcggc ggtcaaggag gccctccaag 1195201 cggcggagat ggcggccaag gcggacccgg cggagacgga gggaaaggcg gtacaggaac 1195261 cggttcgaaa atgcaatcag gttcagggat gtttggaacg ggaacacctg gtccactgcg 1195321 gcttttccaa caagagttat ctgatcaaat cagctggctt ctgccatttg cgatatttgg 1195381 aatcgcaggc ttactgatcg ctggcgcaag agaaagaaga agattatctg tagagcagaa 1195441 ggaaacggtg ttctgggttg cgtggcttgt accgattgcc ggattcttca gtgtcgcaga 1195501 atttttccat cattattatc tcatcatgct ggcaccgccg attgcggctc ttgtcggtgc 1195561 ggggtgggtc gctcttgttc atctgtaccg caatcagaca ggctggaaag catggctttt 1195621 gccgggagca attattgcga caactggatt tgaattgttt attctcagaa actacaacga 1195681 tcaaatcggt gttggatgga gtatcggggt aggtgttatc ggcgtgttgt cagcgattgc 1195741 tttgctgctg tttaaacagc gccaaaaacc gttcagttat tatgtttcac ttgcagctct 1195801 cctcgcattg ctggtgatgc cgatgtattg ggcaagtaca ccgcttctgt acggaggcaa 1195861 cagctcactg cctgaaacag gccctcaact cgcatcaatg agcggaaaag gcatgggaat 1195921 gtctgatgcg actgtaaatg aaaaactgat caaatatcta gaggagaata actccggagc 1195981 tgaataccta ttcgccacaa ccgattcgaa cacagcggca ccatatatca ttaaaacgaa 1196041 aaaagctgtc atggctattg gtggatacag cggttctgac ccggcaatca cactgactca 1196101 attcaaaaaa cttgtaaaag aaggaaaagt gaaatacttc ttggcttctg gaatgggaag 1196161 aggcggaaac aatgacattg ttgaatgggt tgagaaaaat ggaaaagaag tagcatcaga 1196221 aaaatggcaa tcaagttctg atcaaaaaac agaaaatact gattcagctg atacatcaag 1196281 cagcaaggct tcaggtgaaa acggcaaaat gggcggacct ggcggaatga atcagtcagc 1196341 aacattatac gaactacatg ctgatgaata ggaggcaaaa acatgagcag acatattcaa 1196401 tattcaattg ttgtacctgt gtataatgaa gagcttgtca ttcatgaaac ctatcagcgc 1196461 ttaaaagagg tcatggatca aacgaaggaa aactacgagc tgctttttgt caacgatggc 1196521 agcaaagacc gcagtattga gattttaaga gagcacagcc tgatcgatcc gagagtgaaa 1196581 attattgatt tttcaaggaa ttttggacat cagatcgcca ttacggcagg tatggattat 1196641 gcacagggga atgcaatcgt cgtcattgac gccgatttgc aggaccctcc tgaactgatt 1196701 ttagaaatga ttgaaaagtg gaaggaaggc tatgaagtcg tgtacgccgt acggactaaa 1196761 cgaaaagggg aaaccttttt caaaaaacaa accgcggcta tgttttaccg gcttctcagc 1196821 ggtatgacag atattgatat cccgattgat acgggggatt ttcgcctcat ggacagaaaa 1196881 gtctgtgatg aaatgaagag attaaaagaa aaaaatccat ttgtaagagg gctagtcagc 1196941 tgggtgggtt tcaaacagac agcggtcgag tatgtacgtg atgaaaggct cgccggagaa 1197001 acaaagtacc cgctcaagaa aatgctgaag ctgtcaatgg acggcatcac gacattttca 1197061 cataaaccgc tgaagctggc aagctatgcg gggattttaa tgtcaggtac tggatttctg 1197121 tatatgttta tcgtgctgta tctgaagcta ttcacagaca gcacgattac cggctggtca 1197181 tcacttattg tgatccagct cctgttcagc ggcattgtcc ttctgatttt gggcgtgatt 1197241 ggcgaatata tcggcagaat ctacgatgaa gccaaagaca ggccgcttta catcgtccaa 1197301 aaatcgtatg gaattgaaaa taaaagactc tatagagacc agcatatgtc ataacctcaa 1197361 accccctgtc cgtaatggac agggggtttt tatgctctga gcacgatcta aagcaaaaga 1197421 tgctgataga tatatggaaa ttgggtaaag aagagattgt gagcttgtac tgcggttcag 1197481 tcatgctgaa ataaaaacag caaaacttaa agatttcgtc ctcggctttg ctgcatgtca 1197541 gctgttatat tggggggctt ttaagaaacg catgattaga gccgtaccag ttatgtttaa 1197601 tagaatactc gtacccaata caattcccca cgtcaacgtc gattcagaga gaagaaagct 1197661 cagcaaaaga aaagccaatc ctgcgcagat catacccagt cccacggttt tcatgttcat 1197721 gcctcctagc aaacgatgtt tctagcatct gatgtgaatg atgtcaatct gtatgatata 1197781 cggatatctc gtcagaaagt ttcatagaac aattaggtct tttatctaat aaaaagcctc 1197841 agaccgcttt tacggcctga ggcattatgt cttacgaagt tttctcttct ttttgatcca 1197901 gtttaatttt tttcgtcatt tctttgccgt ttcggagaat tttcacttca acggtatcac 1197961 cgatctttgc gtctttatat aagatattgc gcaattcact gcctgtatca atttctttac 1198021 cttttaggcc gatgataata tcctccgctt ttaatccggc cttttcagca ggagagcctg 1198081 aagcgacctc acggatgtaa acgcctttat tcagctggct gccgaacagg ccgagtgtgc 1198141 cttcttggta attttgcggc acttgctcta gatcaagcat gctgacaccg atatatggac 1198201 gttcaatttg tcctttagac agcaattctt cagcaatcgg ttttacgtca ttgcttggaa 1198261 tggcgaatcc gataccctca acatcatcct cactgatttt catactgtta atgccgacaa 1198321 ttttgccgtc tgtatttaac aaaggaccgc cgctgttacc tggattaatt gctgcgtctg 1198381 tctgaatgac gttaatgctc gtttcgccgg ctgatgtaga cattgaaacc gttctgtcca 1198441 cgccgcttac aattccttgt gttactgtgc gggacaggtc ttttccaagc ggatccccaa 1198501 tcgcaataac ggtctcgcct gttctaagat cagatgaatc accgaagttt gccacttttg 1198561 tgacgtggtc atcactgatt tggaggacgg ctaaatcagt taacgagtca ctgcctacca 1198621 gctttgcagt aacctcagtg ccgtcatata aagatacctt cagtgatgat gccccttcta 1198681 cgacgtggtt atttgtaatg atataagcct tgccattctc ttttttgaaa atgacacctg 1198741 accctgaacc gctttctgta tcttcgctgg aatcagaaga actagagccg aacaaagagc 1198801 tgtttgattg tgcctgaaga tttgtaatac cgacaatcgc tggtgaaagg tcttctacca 1198861 tatctgagat tttagaagag tcctcgctct tgaatgcaga tgagctgctt gagctttttt 1198921 tagattcaga ggaggtgctt gttgctgtaa cagattgcgt ttgctgctgg ctggatgatt 1198981 gttttgcagt gtcctgagaa tcatggtcac caagcggtgt aaacgtgtaa atgccaagag 1199041 caagactgcc gccgatcact ccgccaagca acggtctgaa ccatccgaat cctcgttttt 1199101 tcttctcctg atcatgaatg acattgcggg ccgagtagga ggcgctctga tcgttctctt 1199161 tcgttaaaaa gacctcattc tcattacctt tcgttctgtt ttcatcacga tagttatcca 1199221 tcatgttcac tccgtttctc tattttcaca tgtctattta tattgatagg tttatgactt 1199281 gagtttatca taaacaaaaa ctgtgggata aaaatgaaaa gattatggga aattgtgaaa 1199341 aagtgcggaa aacggtacac ttcatattgt atatgaaagg actgagtcga tggaacagat 1199401 tggattgatt ggatatggca gcatggcgga tatgatcgct agacagctgt tgaaacatga 1199461 acaaataaaa gagaatgagc tatttattga gacgagaacg aagggggagc ggctgcgggc 1199521 actcatgtca gattatccaa acgtatcggc tgatccgttg gagaattggg caaatacgtg 1199581 ccaattgatt ttgatatgcg tcccgccact ccatgtcatc gaaacaatgc gccgtctgta 1199641 cccgtatgtg aacagaaata ctcacatcgt atccatagct gccggtgtgc cgctgcgtct 1199701 tttggaggca gaaacagaag ccggtatctc acgtgttatt cctgccatta cgtccgaagc 1199761 agaagccggc atctcacttg tcgttcacag tgaagcactg gctgcagaga aaaaagaacg 1199821 tctgaatgaa ttgttatcgg ttttcagccg tgtacgggaa atcaaagaat cgaatttaga 1199881 tgtggccagc aatttaacga gctcggcacc gggattcata gctgcaatct ttgaagaact 1199941 ggcactgtct gccgtcagaa acagcagcct gtccaaagaa gaagcctttg attttctgat 1200001 tcattcgcta tacggaactg gcaagatgct gatcgaaaaa aatatgtctt tcgaggagac 1200061 gctggaacgt gttgcaacca aaggcggaat aacgggagag ggagctgagg tgatacacgc 1200121 ctctgtgccg gacgtttttg atgaggtatt tgaaagaacc ctgagaaaat atgaactgct 1200181 tacagaacag gttggtaaac aaacatgaat ccttgaaaga ggattctttt tttatcactg 1200241 aatgattgag atttttccca gttatattgc atttttcctc tttttttaat ataatttgtt 1200301 agaatattca taatttagta aaaaaggagg agcgttatga aattgtacat gtcagtagat 1200361 atggaaggta tttcgggtct tccggacgat acctttgtgg attccggcaa gcggaattat 1200421 gaacgcggac ggcttatcat gactgaagaa gcaaactact gtattgctga agcgtttaac 1200481 agcgggtgta ccgaggtgct ggtcaatgac agtcattcga agatgaataa tctgatggtt 1200541 gaaaagcttc accctgaagc agacttgatt tctggtgacg tcaaaccatt ttcaatggtg 1200601 gagggactgg atgatacgtt tagaggcgct ttgtttctcg gttatcatgc gagagcctcg 1200661 actcctggtg tcatgtcaca cagcatgatt ttcggcgtcc gtcattttta cataaacgat 1200721 cggcctgtcg gtgagcttgg attaaatgca tacgttgccg gttattatga tgtcccggta 1200781 ttaatggtag ccggggatga ccgggcggcg aaggaagcag aagagcttat cccgaacgtg 1200841 acgacagccg cagtcaaaca aaccatttca agatccgcag tgaagtgctt gtcgcctgcg 1200901 aaagccggac ggctgttgac agaaaaaacc gcatttgccc tgcaaaacaa ggacaaagtc 1200961 aagccgctca caccgcctga caggccagtt ctgagcattg aattcgccaa ttatggccaa 1201021 gcagaatggg cgaatctgat gccgggaacg gaaatcaaga cgggaactac aaccgttcaa 1201081 tttcaggcga aggacatgct tgaagcctat caggcgatgc ttgtcatgac tgagcttgcg 1201141 atgcggacat cattctgcta aaggggtgtt ttaggctttg gcgcgataca tgataaagcg 1201201 tttttgggca atggcagcta cgattttggt gattaccacc ctgacttttg ttctcatgaa 1201261 ggtcattccc ggatctcctt ttaacgagga gagaggcaca aatgaagccg ttcaaaaaaa 1201321 tctcgaagcc tactatcact tagacgatcc tctcattttc caatacattt tctacttaaa 1201381 atccatcatt acattcgatt tcggaccttc aattaaaaaa ccgtcggaca gcgtaaatga 1201441 tatgctggaa cgcggatttc ccgtttcctt tgagcttggg atgacagcga ttgtcattgc 1201501 tgtgatttct gggctggtgc tgggcgtaat cgctgcactc cgccgcaatg gctttttgga 1201561 ctacgccgcg atgagtcttg cagtactcgg catctccatc ccgaatttta ttctggcaac 1201621 attgctcatt cagcaatttg ctgtcaatct caaactattt cccgctgcga catggacgag 1201681 cccgattcat atggtgcttc cgaccgcagc gcttgctgta gggccaatgg cgatcattgc 1201741 caggctgaca cggtcgagca tggtcgaagt tctgacacag gattatatcc gcacagcaaa 1201801 agcaaaaggg ctttctccgt tcaaaattat cgtaaaacac gcactcagaa atgcactcat 1201861 gcccgtcatt accgtcctgg gcacactcgt cgccagcatc ttaacaggaa gctttgtcat 1201921 tgaaaaaatc tttgccattc cgggaatggg aaaatatttt gttgaaagca ttaatcagcg 1201981 ggactacccc gtgattatgg gaacgaccgt tttttacagc gtcattctga ttatcatgct 1202041 gtttttggtc gatttggcct acggtctctt agacccgcgc attaaactgc ataagaaagg 1202101 gtgaagcgtg tgaatctccc tgtacaaacg gatgaacgcc agccagaaca gcacaatcag 1202161 gtgcctgatg agtggtttgt cttgaatcag gaaaaaaatc gggaagccga ttcggtcaag 1202221 cggccgagtt tgtcatacac gcaggatgcc tggaggaggc tgaaaaaaaa taaattagcg 1202281 atggccggac tctttattct tttatttctt tttgtcatgg cagttatcgg gcccttttta 1202341 tcgccccata gtgtcgtacg ccaatcgctg acagaacaaa atcttccgcc ctcagccgat 1202401 cattggttcg gcaccgatga actcggccgg gatgtgttta cccgaacatg gtatggcgcg 1202461 agaatctcgt tgtttgtcgg cgtgatggca gcactgattg attttttgat cggtgtcatt 1202521 tacggaggcg ttgccggcta taaaggcggc aggattgaca gcattatgat gcggattatc 1202581 gaagtgctgt acggactgcc gtatctgctt gttgtcattt tgctgatggt gctcatggga 1202641 ccgggactgg gcacgattat tgtggcgctg actgtgaccg ggtgggtcgg catggcgaga 1202701 attgtaagag gccaggtgct tcagattaaa aattatgaat atgtactcgc ctcgaaaacc 1202761 tttggcgcga aaacctttcg catcatccgg aagaatttgc tgccgaatac tatgggagcg 1202821 atcatcgtac aaatgacatt aaccgtacct gccgccatat tcgcagaatc atttttaagc 1202881 tttctcggcc tgggcataca ggctccgttt gcaagttggg gcgtgatggc gaatgacggc 1202941 ctgcctacga ttttatctgg gcattggtgg cgcctgtttt ttccggcctt tttcatatct 1203001 ctgacgatgt acgcgtttaa tgtgctgggg gacggattgc aggatgcgct tgaccctaag 1203061 ctgaggaggt agctgtatgg aaaaagttct gtcagtccaa aatctgcacg tgtcttttac 1203121 gacttacggc gggacggttc aggcggtcag aggggtgagc tttgatttgt ataaaggaga 1203181 aacctttgcg atcgtcggcg aatccggctg cggcaaaagc gttacctccc aaagcatcat 1203241 gggcctgctt ccgccttatt cggcgaaggt gacagacggc aggattctat ttaaaaacaa 1203301 agacctttgc cgtctctctg acaaagaaat gagaggtata aggggagccg acatttctat 1203361 gatttttcaa gacccgatga cggcgttaaa ccctacgctg actgtcggcg accagctggg 1203421 ggaagcgcta ttgcgccaca aaaaaatgag caaaaaagcg gcacggaaag aggtgctttc 1203481 catgctgtca ttggttggta ttccagatcc cggagagcgc ctaaagcaat atccccacca 1203541 attcagcggc ggtatgagac agcggattgt cattgcgatg gcgctgattt gcgagcctga 1203601 tatcttaatt gcggatgaac cgaccaccgc cctggatgta accattcagg cacagatttt 1203661 agagctgttt aaagagattc agagaaaaac ggatgtgtct gtcattctga ttacgcacga 1203721 tttaggggtt gttgcccagg tagctgacag agtcgcagtc atgtatgccg ggaaaatggc 1203781 ggaaatcggc acaagaaaag atatttttta tcagccgcag cacccatata caaaaggcct 1203841 gctgggctct gtcccgcggc tggatttaaa tggcgctgag ctgaccccga ttgacggaac 1203901 gccgccggat ttattttcgc ctccgccggg ctgcccgttt gccgcccgct gtccgaacag 1203961 gatggttgtg tgtgacaggg tgtacccggg ccagacgatc agatctgact cgcacaccgt 1204021 caactgctgg ctgcaggatc aacgagcaga gcatgcggtg ctgtcaggag atgcgaagga 1204081 ttgaacatga aaagggggaa gaggatgaaa cgagtgaaaa agctatgggg catgggtctt 1204141 gcattaggac tttcgtttgc gctgatgggg tgcacagcaa atgaacaggc cggaaaagaa 1204201 ggcagtcatg ataaggcaaa aaccagcgga gaaaaggtgc tgtatgtaaa taatgaaaat 1204261 gaaccgactt cattcgatcc gccgatcggc tttaataatg tgtcatggca gccgttaaat 1204321 aacatcatgg aggggctgac gcgtcttggc aaagatcatg agcccgagcc ggcaatggcg 1204381 gagaaatggt ctgtttcgaa agataataaa acttacacat ttacgattcg ggaaaatgcg 1204441 aaatggacaa acggagatcc tgtaacagcc ggagacttcg aatacgcgtg gaagcggatg 1204501 cttgatccga aaaaaggcgc ttcatcggca ttcctaggtt attttattga aggcggcgaa 1204561 gcatataaca gcgggaaagg gaaaaaagac gatgtgaagg tgacggcaaa ggatgatcga 1204621 acccttgaag ttacactgga agcaccgcaa aaatatttcc tgagcgttgt gtccaatccc 1204681 gcgtatttcc cggtaaatga aaaggtcgat aaagacaatc caaagtggtt tgctgagtcg 1204741 gatacatttg tcggaaacgg cccgtttaag ctgacggaat ggaagcatga tgacagcatc 1204801 acaatggaga aaagcgacac gtattgggat aaggatacag tgaagcttga taaggtgaaa 1204861 tgggcgatgg tcagtgacag aaatacagat taccagatgt ttcaatcagg ggaacttgat 1204921 accgcttatg tccctgctga gctgagtgat cagctgcttg atcaggataa cgtcaatatt 1204981 gttgaccagg cgggtctcta tttctatcga tttaatgtca acatggagcc gttccaaaat 1205041 gaaaacatca gaaaagcctt tgcgatggct gtggatcaag aggaaattgt aaagtacgtc 1205101 acgaaaaata atgaaaaacc ggcgcacgcc tttgtatcgc ctgggtttac gcagcctgac 1205161 ggcaaagatt tccgtgaagc aggcggagac ctgatcaagc ctaacgaaag caaagcgaag 1205221 cagctgctcg aaaagggcat gaaggaagaa aactataata agcttcctgc gatcacgctt 1205281 acttacagca caaagccgga gcataaaaag attgccgaag ctattcagca aaaattgaaa 1205341 aatagccttg gagtcgatgt gaagctggcc aatatggaat ggaacgtatt tttagaggat 1205401 caaaaagcgc tgaaattcca attctctcaa agctcatttt tgcctgatta tgcagaccct 1205461 atcagttttc tggaagcctt tcaaacggga aattcgatga accgcacagg ctgggccaat 1205521 aaagaatacg atcagctgat caaacaggcg aaaaacgaag ccgatgaaaa aacacggttc 1205581 tctcttatgc atcaagctga agagctgctc atcaatgaag cgccgatcat tccggtttat 1205641 ttttataatc aggttcacct gcaaaatgaa caagtaaaag gaattgtccg tcaccctgtc 1205701 ggctatatcg atttaaaatg ggcagataaa aactgatgga ggcgattgag gaaatactgc 1205761 ttctttatgc gaaggagcgg tattttttct ctttcttgca cgtatacgta gggtgcagag 1205821 caaatgaaag gagtgttttc gttgaattac aagccgaaag cgttgaacaa gggtgataca 1205881 gtcggagtga tcgcgcccgc aagtccgccg gatccaaaaa agcttgacac cgcgctttta 1205941 tttttagaag agctcggtct tcaggtgaag ttgggcaagg cgctgaaaaa ccagcacggc 1206001 tatttagcgg gacaggatga tgagcggctg gcggatctcc atgagatgtt cagagacgat 1206061 gaggtaaaag cagtgttgtg cgcatgcggg ggttttggga caggacgtat cgccgcgggc 1206121 attgatttca gcttgatccg caaacaccct aaaatctttt ggggatacag cgatattacg 1206181 tttttacata ctgccattca tcaaaacaca ggtcttgtca ctttccatgg cccgatgctc 1206241 agcacggata ttggccttga cgacgttcac ccgctgacaa aagcgtcata taagcagctc 1206301 ttccaggaga cggaattcac ctatacagaa gagctttctc cgctgaccga gcttgttcct 1206361 ggaaaagcgg aaggcgagct tgtcggggga aatctgtctt tgctgacgtc tacactgggc 1206421 acgccatttg aaattgatac gagaggaaag cttctgttta ttgaagatat tgacgaggag 1206481 ccttatcaaa tcgaccggat gctgaatcag ctgaaaatgg gggggaagct gacggacgcg 1206541 gcgggaattc tagtttgtga ttttcacaat tgtgtcccgg tgaagcgaga gaagtctctc 1206601 tcgcttgagc aggtgctgga agactatatt atttctgcgg gcaggcctgc tctgagagga 1206661 tttaaaatcg gccactgctc gccaagtatt gccgttccga tcggtgcgaa agctgctatg 1206721 aatacagcag aaaaaacagc cgtaatagag gcgggcgttt cagaaggggc gctgaagaca 1206781 tgaaaatcat tcgaatcgaa acaagccgaa tcgctgtccc gctgacaaag ccgtttaaaa 1206841 ccgcacttcg cactgtgtat acggctgaat cagtcatagt aaggattact tatgacagcg 1206901 gtgcagtcgg atggggagaa gcacccccga cgttagtgat tacaggagac agcatggata 1206961 gcattgaaag tgccatccac catgtgttga agccggcatt gcttggaaaa agcctggcgg 1207021 gctatgaggc cattctgcac gacatccagc atcttcttac aggaaatatg agcgcgaagg 1207081 ctgctgtaga aatggctcta tacgacggct gggcgcagat gtgcgggctg ccgctttatc 1207141 aaatgcttgg cggatatcga gatacgctgg aaacagatta tactgtcagt gtcaactcac 1207201 ctgaagagat ggcagctgat gccgagaatt atctcaaaca aggctttcaa acgctgaaaa 1207261 taaaggtcgg aaaagatgat attgcaacag atatcgcccg tatccaggaa atcagaaaac 1207321 gtgtcggatc agctgtgaaa ctgcgtttag acgctaatca ggggtggagg ccgaaggaag 1207381 cggtaactgc cattcggaaa atggaggatg cgggcctagg cattgagctt gtcgagcagc 1207441 ctgtccataa agatgatctc gctgggctta aaaaggtgac agatgcaaca gatacgccga 1207501 ttatggctga tgaaagtgtt tttacaccgc gccaggcgtt cgaagttctg caaacccgga 1207561 gcgcagactt gatcaatatt aaattgatga aagcgggcgg catcagcgga gcagagaaaa 1207621 ttaatgccat ggcggaggcc tgcggggtgg agtgtatggt cggcagcatg atcgaaacga 1207681 agctgggcat tacggccgcg gcgcattttg cggcaagcaa gagaaacatc acacgctttg 1207741 attttgacgc gccgctgatg ctgaaaacag atgtattcaa tggcggcata acatatagcg 1207801 gcagcacgat ttcgatgcct ggcaaaccgg gcctcggaat catcggggct gcgcttttga 1207861 aaggggaaaa agagcaatga tgcacactgt catatcagca gtggccaaca tctggacagc 1207921 gcctgattca cctcgtccgt ctgatcaatt catgcttcaa ccgactgtaa tgatcagaga 1207981 ctggctggag cgcatgacgt atgatgaacg gcttggatta tgtacagaca atgtaatcca 1208041 aactcaggtt ctctttggcg aaaaggtact tgtgacggcg gaacaggggg aatgggtttc 1208101 tgtgatcgtg cctagccagc catcccgaaa ggatccgcgc ggatacccgg gctggatgaa 1208161 aaagtaccag ctggaaaaaa caaagcccat ccatacacaa cacgatgtga tgatcagcaa 1208221 acctgctgcc tttttgtaca gaagcaatgg ggaaaaggag atcgaattaa gctttttgac 1208281 agttctgccc cttattgcaa aagaaaacgg atattttaag gtttcgaccg tttttgggga 1208341 aaggtttgtg aggcaaagtg atgcagtgcc tgtcagccaa cagaaaggga ctgctgaaga 1208401 catcattcaa acgggtgcgt tttttcttgg ccttccctac ctgtggggag ggatcagcgg 1208461 gtttgggttt gattgctccg gatttatgta cagtatattt aaggcgaatg gatacagcat 1208521 cccccgtgat gcgggagatc aggctaaggc agggaagggt gtcccgcttg atgatatgaa 1208581 agccggtgat ctgctgtttt ttgcttatga ggaaggaaaa ggagcgattc atcacgtcgg 1208641 tctgtatgta ggcggcggga aaatgcttca ttctccaaag acagggaagt caatcgaaat 1208701 cctcacatta acagagacaa tctatgaaaa agaattatgt gcggtgcgcc gctgtttttc 1208761 agaataagga gggagacaaa tgaggcgact gcctttgtta gaggtcagcc agctgaaaat 1208821 gcattttgac gcagggaaaa agcggacagt caaagctgtc gacggggtca cctttcagat 1208881 tcgtgaagga gaaacgttcg ggctagtcgg ggaatcaggg tgcgggaaat caaccttggg 1208941 gagagtgctg atgcgccttt atcagccgac agaaggaagc gtgacatacc gcggcacaaa 1209001 tcttcatgca ctaagtgaaa aagagcagtt tgccttcaac cgcaaactgc agatgatttt 1209061 tcaggaccct tatgcttcac ttaacccgcg catgaccgtt cgagaaatta ttttggagcc 1209121 gatggagatt cataatctct acaataccca taaagcacgg cttctcgtcg tggacgagct 1209181 gcttgaggca gttgggcttc accccgattt tggcagccgt tatccgcatg aattcagcgg 1209241 cgggcaaagg cagagaatcg ggattgcgag agcactgtcg ctgaatcctg aatttatcgt 1209301 ggcggacgaa ccgatttctg cacttgatgt ctctgttcaa gcgcaggtgg tcaacctgct 1209361 gaagcggctt caaaaagaga aagggcttac gtttttattc attgcccatg atctttcgat 1209421 ggtgaagcat atcagtgaca ggatcggtgt tatgtactta ggacacatga tggaaattac 1209481 agagagcggc accttgtatc gtgaaccgct ccatccctat acaaaggcgc ttttgtcctc 1209541 gattccgatt ccagatcctg aattggagga caagcgtgag cgtattctct tgaaagggga 1209601 gctgccgagc ccggtcaatc cgccaagcgg ctgcgtgttt cgtacccgct gtccggaggc 1209661 gatgcctgaa tgtggagaat ctcgtcccca gcttcaagaa atcgaacccg gccgttttgt 1209721 cgcttgccat ttgtatcgaa atgctgaaac gaaggaaaaa gtaagataaa taaaaagagt 1209781 ggctcctttt tactagagcc actccatttg tttatacttg atgtaaaaac tttacacaaa 1209841 ccgggtaagg gacagaaacc gttgatggga ggagtgtcaa tcggccggtt tctttgtctc 1209901 tttcaaacaa gacaaggttg cctgtttctt catttgaagc aacgaggaac ccttccgttg 1209961 ggtcaaatac aaagtcacga ggccagtttc cttctgtcga cactctttct acgaaagcca 1210021 gctctcctga atattgattc acttcaaata cggcgatact gtcatggccg cggtttgcga 1210081 cataaacaaa acgtccgtcc tgcgtgacat gtattgcgct tccctggctg ttatctgtaa 1210141 aatcatcagg gatggcagaa acgacttgga tttctctaaa ttcgccggct gtcgggttgt 1210201 attcaagcgc aatcacttca ttgcttaatt ctgtcatgac ataagcgtat ttttctttcg 1210261 gatgaaaagc gatatggcga ggtcctgcac cgggagcgaa ggaatggctt ccggattcag 1210321 tcaacacacc gtctttaagc ttataggtgt agagcttatc tatacctaaa tcaaccgcta 1210381 ccacataatt gtgttcaggt gtgaaccccg cgtagtgtgt atgcggtttt tcttgtcttt 1210441 cgtgcggccc ttttcctgtg tgagcggcct ctgaaacagg tgattgcaag ctgccgtctt 1210501 cctgaaccgg aaaaacgtgt accttcccgc tgtgataatt ggcagtcagt acgaattgat 1210561 tttgatcatc aacgcttacg tggcatggcg aagggccatc aattaactga tgattcagaa 1210621 atgtcaattc gccgctgttt ttatcgattt gataggcagc aactccgcct tggccgtctg 1210681 ctttttcgat ggaataaagg atggtgttgt ttttattcgt cgccacatat gtcgggttgc 1210741 ccagcttagc ggccagcttt ggctcgctga gtgctttttt ctcagtatca agctcaaatg 1210801 aataaattcc ttcgcttccg ccttttgtat atgttcccac atatcctatg tattttgtca 1210861 tgcgatttcc cccttaaaaa tgatgtcacc tctatattaa cgtatcttga taaaataagc 1210921 tgttcaaaac atgaaaaagg ggaagattct tcattcgcct cgaatcagcg gcattgtgca 1210981 gcacctgaag gagccgcctg atttaataat ttctgacagg tcaatttcga taatgtgata 1211041 gcctcttttc gatagctgtt gattgacatg gcggttgcca gggagactga tgatcgtttt 1211101 ttttccgatt gaaaggacgt tggtgccaag cgtaaattgt tcgtcctcgg gcacctcaat 1211161 aagatcataa cgttttgcca gcatatcggc tgcatctggc tcaatggcct gtgaataaat 1211221 taacgcttcg ctttcagata taatgttaaa tacgcagtcc aaatgcaaaa atttttcatg 1211281 aagcttcact ggaacgatcg tatattcagg aagtgcctct tctagctggc cgatagctga 1211341 aatgtcggtg cgctggctga ttccgacata gacaatgtca tcatcgataa tgacgtctcc 1211401 gccttcaata ctcgtatcaa gcatgcgggt gtaagagata ccttggctgt gaaaaaaatc 1211461 ttttataacg gcttcttctc cttggcgaat cggttcagtc atgcttgaca gaaaggcttt 1211521 ttctccgatg acaaatccta tgtccctagt aaaaacctgt tctgggagtc cgtcgcgaac 1211581 gggcaaaagg acgacctcaa cgttgtgtga cctaagtgcc tccactaagc ggctgtgctg 1211641 gtcgttagcg gtttttacat gaatattgtc atcttcaaaa tgtttttgtg tttcgtttat 1211701 aacatctttt atggtcatgt gctcaggttt gcataagatc actttttgaa gtgtgccgta 1211761 ttccgttcgg cataccgttt tgtgctgaga tttcgggatg gatacgtcca tttgtttttc 1211821 ctcctaaagt gtgaagaata catttattat tccctcatca tgaaaatcat taaaccattt 1211881 taaattttag acaaatggaa gagaatattg tttaatagga gaatataagt gcatttagct 1211941 aaaagatcag acatcaaagg ggagaaaggt atggaaacac cggaaacaag attttgtaaa 1212001 gagtcaaagg ttgtgaaaac cagcagggtg ttcccgcttg acacgaacaa ccataatacg 1212061 ctgtttggcg gaaaattaat gagctacata gacgacattg cctctatttc agcggcgcgc 1212121 cattgcagac gtgaaacggt aacagcttca atggattctg tagatttttt aaagccgatc 1212181 gggcaaaagg attctgtctg cctagagtca tatgtgacat gggtcggcac atcttccatg 1212241 gaagtatttg tgaaagttat taaggagcat ttgatgactg gcgaacggga actcgctgcc 1212301 acatcctttt tgacatttgt cgcattagat tcaaatggca agccggtgcc tgtaccgagg 1212361 gttgtaccgg aaacagaaga agaaatcatg ctgcataata cagctgtaca gcgtgctaat 1212421 gaacgtaaga accgcaagag acacagccag gcgcttgcaa atgcgctcgg aactgataag 1212481 ccttggtgaa cgttaaaccc aaaacataag ttgttttggg tttttttgta cttttcaatg 1212541 gtgattatta caatggttag tccgtttttg ctaggggatt ctataaaaaa gcaacaaatg 1212601 tcatgttaaa ttgataattt tgtgacaact ttattaaaga ttcattttag atatatcttt 1212661 tattcgtaag atcatgtatt ttaaagatat attttaaata catcttttcg aaaggattgt 1212721 ttataaaatg ttagataaca aaacaatcga aattattaaa agcactgtac ccgtattgca 1212781 acagcatgga gaaacaatca ctggccgttt ttacgatcgg atgtttcaag accatccaga 1212841 gcttttgaac atttttaatc aaacaaacca aaagaaaaaa acacagcgaa ctgcactggc 1212901 aaatgccgtt attgcagctg cggcaaacat tgaccaatta ggaaacatca ttccggttgt 1212961 caaacaaatc ggccacaagc accgcagtat cggaattaag cctgagcact acccaatcgt 1213021 cggtaaatat ttgctgattg cgattaaaga tgtattggga gacgctgcaa ctcctgacat 1213081 tatgcaggca tgggaaaaag cgtacggagt cattgctgac gcgttcatcg gaattgaaaa 1213141 agacatgtat gaacaggctg aagagcaagc cggcggctgg aaggagtata agccattcgt 1213201 tatcgcaaaa aaagagcggg aaagcaaaga aattacatcc ttctatttga aaccggaaga 1213261 cagcaagccg ttacctgaat tccaagcagg gcaatatatc agcatcaaag tgcggattcc 1213321 tgattctgaa tatacgcata tccgccagta cagcctgtct gatatgccgg gaaaagacta 1213381 ttatcgaatt tcagtgaaga aagatggtgt cgtgtcttcc tacttacacg atgggctgca 1213441 ggagggagat tcaatagaga tcagcgcacc ggcaggggac tttgttttag atcatgcatc 1213501 acaaaaagat ctcgttttga tcagtgccgg agttggcatt acaccaatga tcagcatgct 1213561 gaaaacatct gtttccaaac agcctgaacg gcaaattctg ttcattcatg cggcgaaaaa 1213621 cagtgaatat catgcattgc gccatgaagt agaagaagca gcaaaacatt ctgctgttaa 1213681 aacagcattt gtgtatcgcg agccgacaga ggaagaccgt gcaggtgatc tgcattttca 1213741 tgaaggacag attgatcagc aattcctcaa agaactgatt gccaacacag atgcggatta 1213801 ctatatttgc ggttcaccgt cgtttattac ggcaatgcat aagcttgtat cagagctcgg 1213861 atcagcgccg gagtctatcc attacgagct attcggcccg caattaagtt tggcgcagtc 1213921 cgtttgaaca catacatgaa actcttctcc tttcagagaa gagtttttta ttgagatata 1213981 agaaggcaga caagcgccgg tttctacatc cggacaatca cagacccgct gccatttgtg 1214041 catacacggt tttgctgttc ttgcattgtt ctcagcaatt cattgtttac ctcaatcgct 1214101 ctaattagtt gcttcattct tagctccaaa ccggccagcc tgtcgattgt ttgctgctgg 1214161 tagccctcgg gttggggagc caatggcaga tcaaagggcc aaagggtatt cgacttctga 1214221 tttttcatat tgcgtattgc gcctccaatc ggtgtcactt tctattatgt tatgttcagg 1214281 cgatatgcac gttcgcctag acactgatgc atagagggcc tgccacgggg cacaataggc 1214341 tcaatatgac cagcggatgg aggtaaagat cggtgttatg gatggtatgg gtatttttac 1214401 tgaagccagt tatcgtattt tcgattgcat atattttgtt tcggcttgcc ggtaaaaaag 1214461 ctgtgtcaca aatgaacaat tttgacctgc ttttgacctt cgcaatcgga accattatca 1214521 gtgagccgat ccttacatcc aagctgccga tgtcaattta ttatgcgggt gcttttttgg 1214581 tgctttatct tatcatgagc aagctctctt tatctaataa atggcgatgg ctcctagtcg 1214641 tgagcccgac tgtcctaatc cgaaacgggg atattgatga acgcggcctt cgtaaagaaa 1214701 ggctgactgt taatgagctg ctcggaaagc tgagggaaaa gggctatgcc gacccggctg 1214761 acattgatct tgctatcatt gaagaaacgg gagaagtaag cgtcatcccg aaagaggaag 1214821 cgagagcggt gcaggtgcgg gatttgaata tggaagctga acggaatttt atcccgattc 1214881 cgctcatact ggatggcgaa atccttgatc ataatttgaa atatctccaa aaaaaccgat 1214941 cctggctgtt tgagaagctt gaggaaaaag ggtacagccc caaactgctg tcttcgatta 1215001 tccttggcac gatgaatgca cgcggtgata tatcccttga tttaaatacc gctaatgaac 1215061 cgcagcatga tccttactta tataaaccgg gaaataacaa ttaagatggc tctctcttgt 1215121 aatgagagct tttttctttt ttaaagggaa tttttgtttg gtgtcaaatg tacctagtta 1215181 ggaggggaac tgaacatgaa ggacttatcc ataagaaacg acatggcgcc aacggtcagt 1215241 ttgctgtatt ccgcagtgga agaaaacagt ctccgtctgg cttccatcgt aagccatatg 1215301 acacacagtg aactttacta taaggggcgc tgccaaacaa aaaacagcac ggctcagctt 1215361 ttgcaccata tcacaaatgt tgatatcaga tgggtctggc gtatcaagga aaatcggatc 1215421 ccggaccata ttgaacaggc atacggcccg atgacagatg aaagcggacg gctgcctgaa 1215481 ccggtgaatc agccagactt agatgaactc ctgaaaagac atcagcatgt agtagagaag 1215541 ctgaaatcgg tatgcttcac tttaactgaa aatgctttga accagccgct ttccttcgaa 1215601 ggtgacaccg cgacgatacg atggggaatt tggcatatgg cagatcataa ccgctatcat 1215661 caggcacata ttgaagctct caaaaaagaa tggaagcagg atgtggcgaa gtatgaacgc 1215721 taaaacgaag cttgtgactg atcgaattcg tttgcgctgt atggaagatc gggatcaagc 1215781 cactttgttt gggctgcttt ttaatgatcc tgacgtcatg acatattatt ccggtttaaa 1215841 agataagagg caaacccgcg agtgggtcaa ttggaaccaa cgaaatgaaa aagggtacgg 1215901 cgttagtctg tggatcgccg aagataagcg gacaggggag tttttggggc aatgcggcat 1215961 cgttccccag cagatcgaaa atcaaaccgt aatggaaatt ggctatatgt ttgcccgccg 1216021 ccactggggg aacggctatg cgcaagaagc ggctcgggcc tgtctggact atggctttaa 1216081 cgagcggcag ttcggcaaaa tggcggcttt gattgatccg ggtaacaaag cgtccatacg 1216141 ggtagcggag aaaatcggca tgcattacag caaaacgatc agaaaatgga ataaaccgat 1216201 cgcggtatat gaaagaaaat cttacaattg aaagatagag ctgagtttag tatcatgata 1216261 tcatgtaaag ttttctaggg ttccgcatgt caattgacat ggactggtcc gagagaaaac 1216321 acatacgcgt aaatagaagc gcgtatgcac acggagggaa aaaagcccgg gagagtcaat 1216381 ctcatgtgag acgactgtcc ggggtttttt tgttttcgga gaatcttaat agatagaaag 1216441 gaatgactca aaatgaaatg gggattggtc gtgcttgccg ctgttttcga ggttgtttgg 1216501 gtgataggct taaagcacgc tgactcagcc ttaacatgga gcggcactgc catcggcatc 1216561 atattcagct tttaccttct aatgaaggcg actcacagtc tgcctgttgg taccgtgtat 1216621 gccgtcttta ccgggctcgg cacagcggga acagtactta gtgaaatcgt tctttttcat 1216681 gaaccggttg gatggccgaa gctattgtta attggcgtgc tcttaatcgg tgtaatcggg 1216741 ttgaagcttg tgacacagga tgagacagag gaaaaaggag gcgaggcata atgctgcact 1216801 ggatcagttt attgtgcgcg ggctgtttag aaatggccgg cgtggccctt atgaatcaat 1216861 atgcgaaaga aaaaagcgtg aaatgggtgc tgttgatcat tgttggtttt gccgcttcat 1216921 tttccttgct gtcgtacgca atggaaacca ctccgatggg aacggcttac gcggtctgga 1216981 caggaattgg caccgccggc ggggcgctta tcggcatcct cttttacaag gagcagaaag 1217041 acgccaaacg gatcttcttt atcgcgttga ttttatgctc agcagttggt ttaaaaattc 1217101 tgtcataaat tgatttttat caaatcttca gtataatgga taaatagttt agacttacaa 1217161 agataagagg gattattcat gaaatcatat atgactcagc ggttggacga ataccgtgac 1217221 ggaaatgagg ataaaggtcg gctcttggtc agctgccccg atcagccggg tatcgtctct 1217281 gcagtttccg cgtttttatt tgaacacggt gccaatatta tagaatcaaa tcaatatacg 1217341 acagaccctg aaggcggccg gttcttcctg agaatcgaat tcgactgcgc aggcattcgt 1217401 gaaaaaaaat catcacttca ggcagcgttt gcctctgttg cggaaaaatt cgacatgaca 1217461 tggagcttaa ctttggcgag cgaactgaag cgtgtcgcca ttttcgtttc aaaggagctc 1217521 cactgcctgc atgagctgat ttgggaatgg caaaccggca acctgatggc ggagatcgct 1217581 gttgtcatca gtaaccatga ggaagcgaga gagctggttg agcgcctgaa cattccattc 1217641 cactatatga aagcgaacaa agacatcaga gcggaagtcg aaaagaagca gcttgaactg 1217701 ctggagcagt acgatgttga tgtgatcgtg ctcgcacgct atatgcagat tctaactcct 1217761 gattttgttt cggctcatcc gaatcgcatc atcaatatcc accattcatt cctgccagct 1217821 tttatcggtg cgaatccgta caaacgggcc tacgagcgcg gcgtgaaact gatcggtgcg 1217881 acatctcatt atgtgacaaa cgatcttgat gaagggccga tcattgaaca ggatattgag 1217941 cgtgtggacc accgcgataa tgcggaagcg ctgaaaaaca tcggaagaac aattgagcgc 1218001 agcgtgcttg cccgtgctgt gaaatggcat ttggaagacc gtgtcatcgt tcatgaaaat 1218061 aaaacaatcg tctttaacta gactgcaaga ggcccgcgca atgcgggcta tttttgatga 1218121 caaaaaacct tgacaagtgt cttttttctt tgcataatat aaaaaaatca ttgagcgttg 1218181 aagaggatta gtaagcagac ctttctgtga cagagagcaa aatgaatcgc tgaaacattt 1218241 tgccgcatga aacctgccga acctgccttg gagtcctagg gggaaaacct aggcgcataa 1218301 cctggcgtta caggagagcg gagcgtgcac aagcgcgttc aatcaaggtg gtaccacgga 1218361 aacccatttc gtccttatga atcaggatga aatgggtttt tttattgtag aagagccgcg 1218421 gaggagaata aatgaaaaaa caaagaatag tagtgaaaat aggaagcagt tcgctcacga 1218481 atagcaaagg aagcattgat gaggcaaaaa tcagagagca tgttcaggcg atttccgtgt 1218541 taaaaaaagc ggggcatgaa atgattctga ttacctcggg tgccgtagcg gcggggtttt 1218601 ccagcctcgg ttatccatcc cgtcccgtta ccatcaaagg aaaacaggcg gcggccgcgg 1218661 tcggacaaac actgttaatg cagcaatata tgaatcaatt taaacaatac tcactgactc 1218721 cgggacaaat ccttttaacg agaaatgatt tttcgaaaag agaacggtat cgaaacgcgt 1218781 atgctacgat aatggaatta ttagagcggg gcgtcattcc gattatcaac gagaacgatt 1218841 ctacatctgt tgaagaattg acattcggag ataatgatat gctttctgcg ttagtcagcg 1218901 gattgattca cgcggaccag ctcatgattc tcactgacat taacggactg tatgatgcca 1218961 atccaaatga aaatcctgag gcgaaacgat ttgattattt gccagagatc acgcctgaat 1219021 tgcttggata tgcaggttca gctggatcaa aggtcggcac cggcggaatg aaatcaaagc 1219081 tgttagccac acaaaccgcg ctgtctctgg gagtgaaagt attcattgga actggcagcg 1219141 gagagcaaaa acttgcggac attttggacg gcaggggaga cggcacttat atcggagaca 1219201 aagaactatc ttcggttaac aacacaaggc agtggattca gttccactcg ccgatatcgg 1219261 gagaaattat cattgatgcg ggtgccgaag aggcgatgat ccataatgga agcagccttt 1219321 tgcccgctgg agttgtgggc gtgaacggaa gctttccgaa aggggcggtt gtggaagtca 1219381 ggggaccggg cggcgtgatc ggcaaaggcc aaactcatta ctcctccgag gagattatgg 1219441 aggctaaagg caaacgcagt gacgaacttg attttgagaa aacgtttgag gttattcata 1219501 ggaatgactg ggtcaatgta aaagactagg aggcggaaaa atgagtgaag tttctgtaaa 1219561 agcgaagctg gcgaaagaag cagcagccga aatgatcatg aaaacaacag ccgagaagga 1219621 tgaggcgctc agcctcattg caaacggact ccgcaaagaa ctggattttc tcttggcgga 1219681 gaatgcaaaa gacattgtga acggaaaaga gaatggttta acaccggaca tcattgaccg 1219741 tctctcattg gatgagaaac ggatacgcga tatcgcggac gcggtggagc tcttaatcga 1219801 cttagcggac ccaatcggcg actctcttga aacgattgaa aaagaaaacg gcctgtttat 1219861 tgaaaaaatc cgtgtgccgc tcggtgtcgt aggaatgatt tatgaggcga ggccaaacgt 1219921 cacagttgat gcggctaccc tttgcctgaa gacagggaac gcggttgtgc tgcggggaag 1219981 ctcctcagcc atccacagca acaaagcgct cgtcagtgtc atttacagag cacttgagca 1220041 atcagcgctt ccgattcacg ctgtgcagct gattgaggat acgagcagag agacagcaaa 1220101 agagctcttt acgttaaatg atggcttaga cgtattgatt ccgcgcggag gcaagaaact 1220161 gattgatctc gttgtgagag aatcaacagt tcctgtatta gaaacgggag caggaaactg 1220221 ccacatattc attgacgaaa cagccaaacc gcaaatggca gaaaaggttg ttgtaaatgc 1220281 caaaacgcag cgcccttctg tatgcaacgc gattgaatca ttgctgattc acaaggcttg 1220341 ggcaagacag cacggaaaag aattgctgga ccagctggaa aacgcgggag ttgaaattcg 1220401 cggtgatgaa ttggtatgtg aacttcatcc ttcaagcaaa caagcatcaa aagaagattg 1220461 ggaaaccgaa tttttagcgc ctgtcctcag cgtaaagacg gttgaaaacg tccaagaagc 1220521 tgtaaagcat atccaacaat acggcaccaa tcattctgaa gcgattttaa ctgaaaatga 1220581 caaaaatgcg gtatattttc aaacggctgt cgatgctgcc gctgtctatc ataacgcgtc 1220641 aacccgcttt accgacggct ttgaattcgg ctacggagcc gaaatcggca tcagcacgca 1220701 aaagcttcat gcaagaggac cgatggggct tcctgcactg acttctacaa aatacatcat 1220761 taaaggaact gggcaaatcc gtgaatagcg gggtaatgtt caatgaaaaa gcttatctca 1220821 ttacgagata agctttttta tacgcgaaaa attgacattt caaatttaat tgtgtacaat 1220881 ttaattgtat aaaatatatt gggggaatga aaaatgagtc agccattatt taccgcaact 1220941 gtttcagcgg taggaggaag agaaggaaag gtcatttcat cagaccgcgt tcttgagctt 1221001 gatgtcgcaa tgccggggac accgagagcc aagaaattag aaaaagcgac aaatccagag 1221061 cagctgtttg cagcaggtta tgcagcttgc tttgacagcg ccctgcagct tgtcgcaaga 1221121 acagaacggg taaaagtaga gacagaggtt acagcaaatg ttagcctgtt aaaggatgaa 1221181 gcggaccagg gctataagct gggtgtgacg ctgcaagtaa aaggagaagg agtcagtgca 1221241 tcagaattgg aggcgcttgt gaaaaaagcg cacggcgtct gcccgtactc aaaagcaacc 1221301 tccggaaata ttgatgtgac acttgaagtt gctgaataaa taaaaagagg atgcctgtac 1221361 aaggcatcct caattttttt gatgaagtgt ttccagtaat gtatatagag cggactttaa 1221421 ctgtttgaga tcctccccag actgctttga gagccccaga attgtccctg gaatgtcaac 1221481 cgctttttct tttaataacg ctccgtcctc tgtcaggctg atcaacacgg accgctcatc 1221541 ctcttcagat ctttttctcg taatcaaacc ctgttgttcc attcgtttaa gcatcggagt 1221601 gagcgttcct gaatctaaat acagctgttc gcccattttt ttgacagtaa gcgtttcatg 1221661 ttcccataac aaaagcaaag ccaaatattg agggtatgtt atattcagct tatcaagcag 1221721 cggcttgtat tgctttgtca tctcccgcga actcgcatat agcaaaaaac aaagctgatt 1221781 ctccaatttc atatgatcaa atttattttc cattttgttc accaactctt ttttgtcatt 1221841 cgattctatt gtatctgaaa aacctcactt ttcctattct cggcaaacat agcatgttta 1221901 aaaagatcag aaagggaaat ataacaacta gatacaaata aggaggttgg gaaatatggc 1221961 actatttaca gcaaaagtaa ccgcgcgagg cggacgagca ggacatatta catcagatga 1222021 cggtgttctt gattttgata ttgtcatgcc aaatgccaaa aaagaaggac aaaccggcac 1222081 aaatccggaa cagctctttg cggcagggta tgctgcatgc ttcggcggcg cgctcgaaca 1222141 cgtagccaaa gagcagaata tcgaaattga ttcggagatt gaagggcagg tcagcctcat 1222201 gaaggatgag agcgacggcg ggtttaaaat cggtgtcaca cttgttgtga acacgaaaga 1222261 tttagatcgg gaaaaggcac aagagcttgt caacgccgct catgaattct gtccttactc 1222321 aaaggcaacc agaggaaatg ttgatgtaaa actagaatta aaataatgac cggcatcctg 1222381 aggattctca ggatgttttt tggtgtcgga catgcggggc gggcacagat ttatgataaa 1222441 acttcagaga agcgtttgaa gcatgccttt aaaccaaaag ttacagatga agcgggtggc 1222501 tggcacggtg tctgccgtgc tgaattgcgc gtatatgctg ttttgtattt gcacagggca 1222561 tagcggctac ttggagaaat aacaaggacc aggccgcgca tgcctgatcc ttttaatatt 1222621 ctttcttatt ggcgaagttc cgccatgctt gaaacgggga taaatgctct gttagtgtca 1222681 cttgataaaa ggggatcgtt ctttcttcag caggtttatc aatttcttta taaatgaatg 1222741 aatcatcaaa cccggcttcg gcagcgtctg tgtgctcagc tgcatagaaa acggctttag 1222801 gccgggccca gtagatggcg cccaagcaca ttgggcatgg ttcacagctc gtatacaaaa 1222861 tgcagtcatc aagctggtag gctcctagca ccttacaggc tttccgaata gctgtgactt 1222921 ccgcgtgggc agtcggatca ttgcttgttg tgacgttgtt ctgtccctct gcaataatgg 1222981 ctccgtcttt cacgataacg gctccaaaag gcccgccgat tcctgcattc actccttcac 1223041 atgcgagagt gacagcccgt tttaagaacg tttcatgatt catcccaatc cctcctgtca 1223101 atagagtgtt attagtatag ccgaaaagaa tgcaaagaac attcttaaaa aagtgcaaaa 1223161 taaacaaagt atttggggga tttgctaaat aagaaaccga ttgtggctgt attatagaaa 1223221 aaaaccatct gccaaatgca gatggttttt tcaaattata ctagctgtgt ctgctgtgct 1223281 cttgcctgtt ttgcggcttc aaccatattt ttcaatgctg caaccgtttc ttcctgctgt 1223341 cttgttttca atccgcagtc tggatttacc cagaagcggt cagtcggaca gacggcaagc 1223401 gcatcaacga taatattgta catttcttca gttgacggca cacgagggct gtgaatgtca 1223461 tatacaccaa ggccaagccc tttcaaatac gggtggtttt ttaagtaatc taaaaatcct 1223521 ccgtggcttc tgctatgttc gattgtaatc acatcggcat caagatcatt gattgtatca 1223581 acgatatctt cgaagttgct gtagcacata tgtgtatgaa tttgtgtctc gtttttcacg 1223641 gaagaagtgg ttaatctgaa agcttctgcc gcccaagtca aatactcatc ccaatcgcgg 1223701 gttttcaatg gaaggccttc acgcagcgct ggttcatcga cttgaatgat ttgaatgcct 1223761 gcgtcttcaa gcgctttaac ttctttgcga agggcaagcc cgatttggaa ggcgatttct 1223821 ttcctcgaga tgtcgtttcg agggaaagac cagtttaaga ttgtaaccgg gcccgtcagc 1223881 attcctttca catgcttgga agtcaatgac tgtgcgtaga ctgtgtcttt cactgtcatc 1223941 ggttcaataa attcaacatc tccgtaaatg actggcgggc ggacacagcg tgagccgtat 1224001 gattgaaccc aggcatattt agtgaaggcg aaaccggcca gcttttcacc gaagtattcg 1224061 accatgtctg tccgttcaaa ttcgccgtga acaaggacat caagctccaa ttcttcctga 1224121 atatcaatcc atctttttgt ttccgcattg ataaagtttt gatactgttc atcggaccac 1224181 tcagctttcc gccatttttg gcgtgcgctc cgcacttcag cagactgcgg gaagctgccg 1224241 atcgttgtcg tcggcaaaag cggaaggccg agagattcat tttgtagggc taaacgttct 1224301 tcaaacggaa tcgggcgctt gaagtcttta tcagttaatt gctcaagctc tttcttttgt 1224361 tcagaattgg cgcctgttgc aaactgttta agcgcctgga tatcagcctt agcctgctga 1224421 atctcttcgc tgatcgccgc ttttcctgat actaagcctt ctttcaaagc tgtcagctcg 1224481 gccagctttt cttttgcgta ggataatccg ttcaataggt ctttttccaa atgctcatca 1224541 gggtgtttcg ctactggaac atgcagcagg ctgctggaag gctgaatcca cagttcatca 1224601 acttttgcaa tgctgagaat atcaagaacg gcatcgagac gctcttcaag gtccgctttc 1224661 caaatgttgc gtccgtcgat aacgccggct gccagcactt tatctgtcgg gaagccatgt 1224721 gttttaagct gttccaggtt tctgcctttg tcgtgaacga aatcaaggcc aattccctga 1224781 accgggtaag agatcagctc ttcataagca tcaacagaat caaaatacgt ctgcaaaagc 1224841 acattcaagg atgaaagctc acttgtaatg ctttcaaata attcttttgc gccgcgtaca 1224901 tcttcactag aggcggtaac gagcgccggc tcatcgattt gaacccattt tacgccttct 1224961 tcttcaagct ctttcaaaag ctgtacatat aatggcacaa ggcgtttttg gatcgctttt 1225021 gcttcagacg gttcatagcc tttagcaagc gtaacgaacg tataagggcc gacaatcaca 1225081 ggctttgttt ccacaccgta ttcctgtttg atccggcgat aatcttcgag ttgtttgttt 1225141 cttgtcagac ggaactcaat gctctcgtca tattccggaa cgatgtaatg gtaatttgta 1225201 ttaaaccatt ttgtcatttc actagataca gcgtctttga ttccgcgggc gatagcgaag 1225261 tatgtatcgg tagcgtcagt caaatgtctg aaccgtttcg ggatccagtt gaagctgact 1225321 gctgtgtcga gtacatggtc atactgtgtg aaatcagaaa caggcacaac atcaatctgc 1225381 tggtcaattt gtgtttttac tgcggataaa aatagttcgt cgatttgctt caaaaacgta 1225441 tctttatcag tactgccttt ccaatacgct tcaagtgctt ttttccattc ccggttcagt 1225501 ccgattctcg gaaatcctaa attcgatgtt ttgatggttg tcattgtttc tcctccttta 1225561 tatgtaaaac actctctttc acccgcggat acaggctgct aagaggtttt ctcacaacaa 1225621 aaagcctctt tcccatgaga gaaagaggct tttctacgta aaacactgcc tctctcatct 1225681 ctcagacaca atctgatgga attagcaccg tgccttatga gacatcagtc tcggcgcgaa 1225741 aagcagtgcg ccccatttca caatggtatt acggtcggtt gctgttgggg tcaaaaggcc 1225801 aatccctcgc ccaactctcg ataagagaaa atgttattaa ttttttgaaa agttgaatca 1225861 tttgttggta atcttaacag taattcaaat tcattgtcaa catagaattt gaaattttta 1225921 tttacatgat gtggtgtata ttatataaga aaaataatct tatagggtca acaaatgtga 1225981 ttgctctgct ttttctgcga gctcatcagg agctgttaaa tacaggaatc cattgcctgc 1226041 cagcgttttt gcaatatcaa gaggaagtgt cctgcggatt agctgtgcga aaacctcaga 1226101 ttcagaaagc tttctttgaa atgattcttc ttcatagctt ttgattaaag caagcgcacc 1226161 gctgacatga ggggcagcca ttgaagtgcc ggtcagctta ccgtacttct tgttgggaag 1226221 ggtggataag atgttttctc ctggtgccac aaggtcaatc tctttattcg cgttagaaaa 1226281 ttctgataat tctcgcgcta cagaaacaga tccaactgca atcacttcat tataagctgc 1226341 ggggtaggaa agctcttctg tgcgttcgtc gccgtcacct tcatttcccg ctgcacaaac 1226401 gacaagcact ccgtttttca ctgcgttttt cactgcttct tttagctctg gcacatcgct 1226461 tggccctcca agggacattg agatgatgtc gactttctgt tccaccgcgt agttgatgcc 1226521 gttaattatc cattcgtatt gtccgctgcc gttctcgccg ccaagaacct tcacaatcaa 1226581 taggcttgcc tcaggcgcga ctccggcaat gcctccgttt gaatcattag ctgcaattgt 1226641 tccggcgacg tgtgtgccgt gtccgttgta gtcggaaatc gcatcttcct tgccgccgtc 1226701 gtcatccgtg aagttctttc cgccgatgat ttgatttttt aaatcagggt ggcttgtgtc 1226761 gcagcctgtg tctaatacag caactttaat atttttgcct tttacccctt ttgcccacat 1226821 ttctggcgcc ttaatcactt taatgccctc aggaagctcg tttacatcca tgatctgctc 1226881 attcgtcaca tacgggatca agcggatttc accattcata aaaaagccct ccttttttat 1226941 gcttgcaagt ggattcaagg gtgttgcctc atattatatg aaaaaagcaa gcgctcggac 1227001 agagccattt gaagcatttt gaaaaaatag gatacacacc aaagaattag taatcttcaa 1227061 aatattggat ggcttcaaca tgtatgactg ggattcaact gtaagtcaag ttataatagt 1227121 gttggggaaa ggagcagtgt catgaaactg aatgaaaaat tatatgcatt tttttcagag 1227181 catgtggaac aaatggccga ggaatggatt gaaacgatgg aggaaagtga tccgaattcg 1227241 ctttacgccc tacataatgc aacagtaacg gaagaattga aagagcagga cagagaattt 1227301 taccggcatc tgaattacat gtatgtttta ccggaaaaac aatttctcga agagtttcaa 1227361 gagtgggtca ttgagctgac caacgatcaa aaacatctcg acacaccggt tcagtatgtc 1227421 attcgggagt ttatgagaaa caggagatta tatacgaagt attttgagaa gttcgcagaa 1227481 gaaaatgaat cagcgtttga accgggagag aagcaaaaat gggcagattt gattgtaaaa 1227541 gtatttgatt tcaccattta tacattcgtt gatcacgctg aaatgaatgc caagcagcaa 1227601 ttaaacgccc aaagagaaat gatattggaa ttaagctcac ctgtcattac cctgagcaaa 1227661 tcaacagctc tgctgccgct tgtcggtgac attgataccg aacgggcgaa gtttattctg 1227721 gaaaacacgc ttcaagcttg tgcgaaaaga cgtgtggagc atctgttaat cgatctgtca 1227781 ggtgttgttg tggtggatac gatggtggcg caccagatct ttaaattgat tgaggcgctt 1227841 aatctgatcg gtgtccggtc aaccctgtca ggaatcaggc ctgaaattgc gcaaactgct 1227901 gtacagctgg ggattgactt ttcgaatatt actattaaaa ccaaccttgc ccaagcatta 1227961 aactatcatc aataaaaaaa tccgctatct gtgatagcgg attttttatg atgcgaaaca 1228021 taaagatacg agaaaggatc ccgcgaataa taagaggacg aggcaaaaga acacccagtc 1228081 gcgccggttc acgctcaatg tcctgtagta tgtccggttt ctgcttcctg taaatccttt 1228141 cgattccatc gcaagcgctg tccgttccgc ttttctgatg gcgcttgcca atagcggtat 1228201 ggtatatcgt tttaacgcac tgattttatt aatgatgccg ctctccgccg ctcctcctct 1228261 gattttatga gcctgctgaa tcagctggac ctcatccttt aacagcggaa gaaagcgaaa 1228321 gcctgcaatg acaccgtacg cgagctttgg tgagagcctg cactgctgga caaggctcag 1228381 cataaataga atcggatcgg ttgtaaaaac aaacatcatc gataaggcgg aaaagcataa 1228441 aatacgaaac ccgagagaga tgccgacaga cacattatcg ctgttaatgg agatagggcc 1228501 tgcttgaaac aaaaaattat ccggtgttgt cggcactttt ccaaaaactg cggctgtcca 1228561 cacgcatccg aatgctaaaa tcaaaaacgg aatcgtaaac aacaaccatt ttttcaatgg 1228621 gattccggcc gccagtaaaa cgcccgcaac gatgatgata taaaaacatg ccggagtgta 1228681 agggttgtaa ataaacgaca gcatgacgac acaacaaaaa accgccgccg ctttcacagt 1228741 cggattaatg agatgtaacg gttgcttcat cacgcacctc ctcttgaaat gccatccatt 1228801 catatagaag gggaagggtg agctttgctt tttgaacaag ccctgtttct tgagaaaaca 1228861 actgcgctgg agatccgtca aaggccaggc ctgtatcgtg aagcacaagc acgctgtcag 1228921 catacgaaga gactagctcc atatcgtgtg taatcataag gacagcagtt ccctctgcct 1228981 tgatacgttg aatcatttcc atgcattcag ccgccgtgcg ggcatcctgg ccaaaggttg 1229041 gttcgtctaa taataaaacc tttacgtcat gcatgagcat agtagctacg ctcagtcgcc 1229101 gtttttgccc ttggctgatc gcaaacggat gatgatcagc caaatgcgca agaccaaaac 1229161 gctgcagcag gtgttgcgct tttttctcag tttcagcatt tgctttctgg ccgaacagaa 1229221 gctcgtcata caccgtatcg gtgacgaatt gatgctcagg gttttgaaaa acaaatccca 1229281 tccgtttacg caattctttt tctttatatt tctgcagcgg ctgatcatag agaaggattt 1229341 tgccgctttg cggtttcatg agactggcca gaactgatag gagcgtcgat tttccagttc 1229401 cgttcggacc gacaagcgcc gttaaagagc cttcgcgcaa cgaaaagctg atgtctttga 1229461 aaatcgcctg ctgtcctctc gcgaacgaaa ggctgctgac ttcaagcaca ctctccccag 1229521 aaggggcttt cttctttttg acatgcccgg caggaatagg ctctttgaac agcatctctt 1229581 ttgataaagt aaacggcata ctcagctttt cctgcagatg acagaccttt ggaatggcga 1229641 tgcccaattt ctttagtgtc tccgcttcat gctgaaatag atttttcgtc aggccatcca 1229701 gtgccttttt gcctgatttg tcgagtacga tcgttctctc aatccaaggc gcccattcat 1229761 caagctggtg ctcaatgacg aggaggctga aacctttttc ccgctgaaga tccttcatca 1229821 gatgaacgaa ctcccgagct gagaaagggt ctaaaagaga ggtcggctca tctaaaataa 1229881 taagctcagg ctccatcgcc aaaatacagg cgagagccac tttctgcttt tgtcctcctg 1229941 aaagggttga gatcattttt tcttttaaat gggtaatgcg taatttttct aatacggcgt 1230001 tgattttctc tgtcatttct tcttttggaa tttgcagatt ttccagcccg aacgctattt 1230061 cgtcctccac cgtcagcatg cagaactgct gatcaggatc ctgaaaaacg accccggcat 1230121 gctgagtaat cgtttcggag gtttcagcat ctgtgaccgg cttttgaaat agaaatacat 1230181 gtccggactg aatgccgtcg caagcctccg gatatagacc gtttaaacaa agggcgagcg 1230241 agcttttacc gcatccgctc ggtcctaata ataaaacaca ttctcctttt tgaagctcaa 1230301 acgaaatgtc ttgaaaaacc ggtttctcgt cttcttcata agagaagctg agctgctcaa 1230361 ccgtcagaag ctcatcaaag gcttgcatgt tctgacgccc gcttccgttt ctttttcagt 1230421 tcctttccga gtgccattcc gtttaacaca cctgtataag cgagagagtc gctgacagct 1230481 tttccgagaa gccccgccaa aagcgcgccg gaaatgaggc ggatcacaag cataatgagc 1230541 agataacctg gtgaataggc tgcatagcca gaaacaaaga gatcatagat aaagctggct 1230601 actgaagacc ccataccggc cagcataagg acagggagag agtatgcttt ccagcgtgtt 1230661 gcaagaaata cagcctcagc cccgagccct tgaacaatgc caatgacgat gaccatcggg 1230721 ccagacggat ttcccagcag gcactcaacg agagcggcaa tgatttcaga aacgagcgcc 1230781 gcacccggtt ttcgaatcat gtacgcggcg atcacagaaa cgataaacca aatgccgtaa 1230841 attggttcat aggcgattgg cccaaacata cctgcaagta cgtttccgaa atgtgtaaat 1230901 aataaataaa caacggcaaa tacgatactg ataacggaca tgatgacaat ttcttttact 1230961 ttccagcttt tcatgttatc cctgctttct gttttttctt gatggactgt tagccgaaag 1231021 attcacagtc atggtgatgt ggtttgtttg ctgctcagcc atgcggaaaa cggcctccaa 1231081 tgtgctgaat acgtcatgcg catccccgtc aagctcgctc gcgtaatgga caccctgtac 1231141 gaaagtgcct tgggcttttg caatgtcgac agcctccata atcaatccca tataatccgg 1231201 ctcattcatt ggataaaggg caaattggca cggcgcttcc gccttcaagc ctcggacagc 1231261 atcttcattg acacgcttat cacctttgga aagatatgta tccccctgtg tgtcacccgg 1231321 gcatccaatg gaaaacgtgc cgttcatgac gatgtgttgt tcgctgtttg ctgcatgaag 1231381 gtaaatggct tttgcagcat cgaatacatg atcaatcgat ccgcgtaaca ccgtgctgat 1231441 atggtcggtt ttcgtccaaa ccttggatgt atctgttttt ttcagcgcag acttgatcac 1231501 actgataaaa tcatccgtca tcggatataa agagaagcga aaaccggcga ttctgcttgt 1231561 accgcaaata tgctccattt ctccgacctc ctgttttttt ggtaaaataa aaaactgcat 1231621 atcctaaggg aatatgcagt catagatcga ttaagcgcac aaaaaaatac accattcggt 1231681 caacctgcac ttccccacgc tggtattatc cagatcgggt cataagggat caaagcgcgt 1231741 ttcttccgcg ctttatctca gccaaaacag cacccctagt gctttccgta tacaattttt 1231801 tattttgaca tcataataga tgataagaat cattttgtaa acaacgaaat catttttttc 1231861 atatagggac gggagaggat ggtcaaattt ggaaaaagga cacatattaa ttgtggaaga 1231921 tgaagaaaaa atcgccaggg ttcttcagct tgaattggaa tatgaaggat acagcgtcac 1231981 gatcaaacac aatggcacag aaggtcttga tgcggcagcg gaaggcgggt attccttggt 1232041 gcttcttgat gtcatgcttc cggggcttag cggactggaa gtgctgcgcc gcttgagaaa 1232101 aacggattcg cagacaccgg tcatattatt aacggcgcga gacagtattc ctgataaggt 1232161 aacaggtctg gacatcggtg caaatgacta tgtcaccaag ccgtttgaaa tcgaggaatt 1232221 gcttgcgaga atcagggcgg cgctgcggca aaatggaaca aaaactgaag atatcggcac 1232281 ctttcttaca tatgacgatt tgcgggtgaa cgaaaaaacc cgtgaagtga gacgcggaga 1232341 caaagaggtg gaattaacgc cgcgggaatt tgatctgctc gtctatatgc taaagcatcc 1232401 gcagcaagtg ctgacacggg agcaaattct aagctcagta tggggatttg attatatcgg 1232461 tgatacaaat gtcgtggacg tctacataag atacatcaga aaaaaactgg actatcctta 1232521 cgaaaaacag ctgatccata cgattcgcgg ggtcggctat gccattaagg ggtaaacgat 1232581 gaagctgaag accaagattc atctatacac ttcgatatca ctgttgattt tattaatttt 1232641 ggttcatacc gcagtatatc tcattttttc gtctgcgctg acatcaaagg atgcggcccg 1232701 gcttgctgat gagacggata acattgccga agcgctgcgt gccgctgaaa cagaaggagt 1232761 ggctttgcag gatatgctgc aggcctatct tccggcaaat ggcatggtgc gtgtagtgaa 1232821 tggtgatcaa aaagccgtta tgacgatcac aaaagaaaaa gcctataaag attttcctct 1232881 ctcttttcat agcggcgaaa cggcagatgt gaggaaacct gacggcaagc tgtttgccga 1232941 ggctgctgtt ccggtgattt ggaccgatgg acaagtcgtg tctcttcagc tggttgaaag 1233001 actggagaac acagaagaga gtctgtttct gctgaaaatc atcttaatcg ctgcaagtgc 1233061 tgctgtctgc attgcttctt tttttgcagg cagcttgcta gcccgccgaa tcatcaatcc 1233121 gatcagacga ttaatgatca caatgaaaga catacagcga gacaaagaat ttaaaacgat 1233181 ttctttagaa ggacagtcca acgatgaatt gtatcaaatg gggctgacat ttaatgaaat 1233241 ggcaatgatg ctgaaggagc actatgataa acagcagcaa tttgttcaag atgcttcaca 1233301 cgaattgaaa accccgctca ctattataga aagctacagc agcctgatga agcggtgggg 1233361 tgcaaaaaag ccggaggtgc ttgaggagtc gatagaagcc attcactcag aagcggtgca 1233421 tatgaaaaaa ctgaccaatc agcttttggc gctggccaaa agccatcaag gactcgaggt 1233481 tgatctgaaa acaatcgatc tgattaaagc ggcgcgcgcg gttatgcaaa cgctccagtc 1233541 cgtttatcag cgtgacatat tgcttgaaac agataaagag agcctgcttg taaaggcaga 1233601 tgaagaacgc atcaagcagc tgttgaccat tttgcttgat aatgcaataa agtatagtga 1233661 aaagcctatt gagatgtcag ccggaacgag gaatggacgg ccatttctat cagtgaggga 1233721 tgaaggcatc ggaatacctg aggagcatat cccgcatttg ttcgaacggt tctaccgggc 1233781 agatgaggca cgaaacagaa aaacaggcgg aacaggttta ggcctttcca ttgccaagca 1233841 aatcgctgat gagcatggca ttgagctgtc tgtcaaaagc aagccgggac aaggaacagc 1233901 tgtcaccatg caattcagcg aacagaatgg gggaggccga tgactaaaac aataaaaaca 1233961 gtatcttttg ctgcagcagc cattttagtt gtcatcatct gtacgtttct catcattcgg 1234021 caaacccatg agaacgtatt gtcaaaggag actgtcgtaa aaaaagtcga agcctcttat 1234081 gaaggcaagg tcacgaaagc aacacaatca aaggataaaa aaacatatga tataaccctt 1234141 gaaaatccaa agggaactta ctttgtaaaa gcagacgcaa tatcggctga cattctttca 1234201 atgaatagag taaaagcagt gaatccatct gccatgacag aaaaagaagc cgagcatctc 1234261 gcgcttgagc gggtgccggg aacggtcaaa aaacaaacac ggcaaagtca agttgccact 1234321 tataccatac aaaaagaaga cgggaaaaca tacgaagtga aggtagacat gcaggcaaaa 1234381 acagtcttgt ctgccgatca aatcagcagc aaagatcaac aaaaaacgcc gattacgaaa 1234441 aaagaagcca aaacaattgc agagcgaaaa acgggcggaa cagcggatga cgcagatctc 1234501 gaagaaagtg agggcactct catctttgaa gtagacgttg atcttcctga taataaggaa 1234561 gcgacagtga aaatcaatgc ctacacagga aaggtagcta acattgtgta tgaagactga 1234621 cggtttctca tcaaattctc atcttgctct cgttttcctt tcatgttgag tatgtaaact 1234681 gtactcatac aaaacaaagg agggctcaca aatgctcaag aaaaaatgga tggtcggtct 1234741 tttagcaggg tgcctagcgg ccggaggatt cagctacaac gcgtttgcca cagaaaacaa 1234801 tgaaaacaga caggcttctt ctaagacgga tgcactcact gaacaagaag cagaagcaat 1234861 tgctaaaaca gttgttgacg gcacagtaga agacattgac agagaccttt acaacggcaa 1234921 agaagtctat gaagtggaga ttgaaaaaga aggtgaagac tacgacgttt atgtagatat 1234981 tcatacaaaa caagcgctta atgacccgtt aaaggagaaa gcagaacaag tcgccataac 1235041 caaagaagaa gctgaagaaa ttgctttaaa gcaaacaggt ggaaccgtaa cagaaagtaa 1235101 gcttgacgaa gatgacggtg cttacatcta tgaaatggaa atccaaacga agcaaggaac 1235161 tgagacagaa tttgaaattt ccgcaaaaga tggacgcatt atcaaacagg agatagatga 1235221 ctaatcaaaa cccccgctgc agcgggggtt tttcatgata agaaaccttc ttttggacaa 1235281 tctaagtaga aaaggaggcg aaacgcatgg aaaagaaaga ggagcaatac atcaatcagg 1235341 ctgaatatgt ccctcatccg acgaaggaag gagagtatgc cttatttctt catgaaacgt 1235401 atcatttgct ttctgaagat gacgagacac aaacaacaga ataagggctt aggcccttgt 1235461 tttgttccgt aattgtgatg taagcgcatt tattactttt ttgagttgac atagcttgtt 1235521 tttttctgta atctcagtgt gtcaattcaa ttaggaactt cgttaggtga ggctcctgta 1235581 tggagatacg ctgctgccca aaaatgtcca aagacgccaa tgggtcaaca gaaatcatcg 1235641 acataaggtg atttttaatg cagctggatg cttgtcctat gccatacagt gctaaagctc 1235701 tacgattgaa ggcgcccgca cgcttttttt gccgtgcttc tttcaccttc aatcccgaag 1235761 gcttttttta tgcctttaaa acgaaaccaa tcaaaggagg tgcggagtat ggattctccc 1235821 cattcgagtc aatctgaaga agtacccata tactatgaca gcaagacaat tgattacacg 1235881 atgaggagac gaactgccgc accttctggc gaggccggca cgtctccgta gaggaggtac 1235941 gagtcccgat ggttcaaaac atgacctatg acgaactcat tttacgcatc attattttac 1236001 tgcgagacgg gaaaatcagg gattttagaa gtgttattga tgagcttcag ccctatgaca 1236061 tggcatttat ttttaaagaa atgccggaaa aacatcgcgc ccgctattta tcttatttaa 1236121 ctgtagacga tatcactgat atgatcgggg agctggaacg cgaatttcag cttgtcgtct 1236181 taaataaagt cggaaaaaca aaagcaacac tggcgatgaa caaaatggac aacgatgacc 1236241 tcgctcaatt gcttgaagaa atggacgaag aactgaagga acagctttta tccagcatgg 1236301 aagcgtcaga atcaaaagct gtacagctct tgatgaatta cccggctgat tcagcgggac 1236361 gcatgatgac aaaccggtat gtgtggatcc ctcagcatta cacggtaaaa gacgcggtcg 1236421 tcaaactgaa aagcttcgct gaaatagctg aatcgatcaa ctacttatat gttattaatg 1236481 aaagcaaaca gctggttggg gttctttcct accgcgattt gattctgggt gaacctgaag 1236541 aaaaggtgca ggatttaatg tttacccgcg tcatatcagc agatgctctt caggaccagg 1236601 aagaagttgc ccgcctgata gaacgttacg attttttggc aataccggtt gtagaagaaa 1236661 acaacgtgct tgtcggcatt gtgacggttg atgatattat cgacgttgtt attcgggaag 1236721 ctgatgagga ttacgaaaaa tttgccgctt ccggtaaaga catcaccttt gacacaaaag 1236781 cttacgtggc ggcataccgg cgtctgccat ggctgatttt actcttattt atcggactga 1236841 tttcaggaag cattatcagc tattttgaag acgcgctgaa gcaggttgtc gcgcttgcgt 1236901 ttttcatgcc gatggtgtca gggatgacag gaaatacggg aacacaatct cttgcggttg 1236961 tcatcagagg tttgtctaaa gaagaaatga acaaaaaaac gattgtgcgc ctgatcttcc 1237021 gggagttcag aacaagcatt tttatcggag cggtttgttc tgtgctgatt gcgattgttt 1237081 ctatcatatg gcaggggaat gcgcttttgg gatttgttgt cgcctcttca ctgttcttaa 1237141 ccttaatcat cggcacgatg tcaggaacga ttatccctat tattttgcac aaactgaaag 1237201 tagacccggc gattgcttct ggaccgctga ttacaacgtt aaacgatatt ttatctttat 1237261 taatctactt tggcattgcc actgcattca ttcactcatt ataaacgtaa aaagtccgtc 1237321 tcaactgcga gccggacttt tattatttaa cggtttttgt accgaaagtg agcattaagc 1237381 tgcccctcca gcattttttt ccgcacttgc ggatcgtttt ttaacatctg ttcttttttg 1237441 cgcatatcct ttaaaatctc tgccgtctgt acgccgtctt cacgcttatt ggcgatatcc 1237501 atcagccgct ccacatcggc aaaggagtat tttcttgtcc cccttgaaga acgctgcggg 1237561 taaatgagct ttcgttcctc ataatacctg atctgtctta cggacaatcc tgtcaattca 1237621 ctcacaattc cgattgaaat cacttttttg tctttataag aatgatcttc tgtggtcatt 1237681 tttccacccc tggatgtctt ttgataatag tatataaaaa acaaagagaa aaaacctgac 1237741 gcttgtcata ttttctaaca tcaaatagaa gatttttgaa aaaatacgga agaaaaatta 1237801 acaagaataa tgcgtaacac ccaagcgcgt tttatccttt atgtaacgaa tcaaacgagg 1237861 aggaaggata atcatggagg aagaaaaagc agtctcactg gcaaaagaaa ttatagagtt 1237921 ggatatcaag cgtgatgaaa tgctggagac gtttatgcag cttgccggag aacaggcttt 1237981 tcaattatta agatcggttc aaaacggaca ataccgaaaa tcttcgtaaa cataaattct 1238041 ttacattaga ttcataccac gttcatttaa aaagagtatc ttttgtatag gatacctcaa 1238101 aatgaaggag gacgctatga gtaatttatt gaaatccgct ttagaaaaag aacgacgcca 1238161 ttattctgaa aaactctatc agataggggt ttataataaa gaggtcatga acaaaatgac 1238221 gatttctgag cttcggaaag aatacgctta tttctttcga agcattacaa atcataaaaa 1238281 ttatccttat acaagataat gtataaggat ttttttgctt ttagaaggaa tttctcgaat 1238341 tatagcgaat acgtatagta agggactgaa ctcttattat atgtaagggt tttcattatt 1238401 tttttataaa aatcctatat acgaggtaga tatgatgaga ttatcgttta acgaagaaga 1238461 agttgagcgt gcgatgaatt tgtacagagt ttttgcaagg gctttcaaaa gtgtgtccga 1238521 acatagtatc cgtgatagca aagagcacgg ttttaatccc actgaatttg ctgtactgga 1238581 actcctgtac acaagaggcc cgcaaaaatt acagcaaatt gggtcgagac ttctgcttgt 1238641 aagcggaaac gtcacatatg ttattgacaa actagaaaga aacgggtttt tagtaaggga 1238701 gcaggacccg aaagataaac gctctgttta cgcacattta actgacaagg gaaatgagta 1238761 tttggataaa atttatccga ttcatgcact gcgtattgcg agagcgtttt caggtctttc 1238821 gcctgatgaa caggaccagc tgatcgtcct gctcaagaaa gcaggcatac acagccagca 1238881 tttgctgttt cgttaactat tctacactct ctatttcagg agagtgtttt tttgtttcca 1238941 tatgattctt tttaaaacat ctttaatctt cctatcagac atttcgccaa ggtatccatt 1239001 gacgtgtttt ttatactcct tcatctgttc gttcgattga aaaaatgccg cgatatactc 1239061 ttctgctttc tgcatgtccc agtttctcat atctgtgacg agtttccttt catgtagaag 1239121 gtttaaattc atttcctcct gtcccggcag tgcatgataa ataaataccg gaagccgttt 1239181 ctgtaagcat tcactgatgg tcacgcctcc gggtttagtc atgatgcctg tcgcctgttc 1239241 gtacaaacgg ttcatctctg ctttgctgtg aaggtaagga atcgcctcaa tcaaggggtg 1239301 gtgtaaactt ttgacatagg agtagagctt ttcgtttctg ccgcataata ttttgtataa 1239361 gatctttccg cctggcgaca gttcctgcac ccattttaaa atcccaccga cccccatact 1239421 gccccctgtg atgatgatgg tatatggcgg gtggtgctgc aaggtatctg ctgattccat 1239481 ttcaaaattt tggtgaactg gaatgccggt caagtatatg ttgttctgat cgataccctc 1239541 tgatattagc tgcttcttta cttccgtgct cggaacaaaa tggtaatcaa tgttcttccg 1239601 tccccataat tgattcacga aaaaatcagt gtatacattc acaaccgtca gattcggata 1239661 ttcaggcttt agtcggttca gcagataaga aggcagcgca tgtgtgcaga aggcgatatc 1239721 aggctgtttt tcttggagga tgtgcctcat ttgctgtgtg aacagccatt cgtacatgaa 1239781 atagcgtttg tcatgctgaa attctccgca ggcgaggagc ctgtaaatgc cgctgtacgt 1239841 tttcgggaaa tattgaatcc attttaaata agccacggag gacaattttt ctaaccgcct 1239901 atacgaatgt gaaaagatat caatcttttc agctgccagc ccttgagact ctaattcagc 1239961 ctgcaatgca tcagccacat gatgatggcc ggtggaaatg cttaaaaaag gaaaaatgag 1240021 aatgtttttc atgacagtcc tcctaaaaaa atatggcaac tatattttga ggagaacgtt 1240081 cacaaaatat aagggtgttt ttgatcataa ggaaggtgaa aagatgaaaa cttgtttcct 1240141 ttccatatgg agagtggttg atccgattta tttctttttt tcaaggctaa gcttgattga 1240201 caacgatcaa aaaagcgttt ttcgagtcag gctgacgaag tacaaaggac atcatgtcgt 1240261 gcttagcgac ggaacgcata taagaaaaaa tgatgtgctc gttaaaatcc acctgcataa 1240321 cataaagctg atcagggagc tgcaaagcat tgagagcgca gtcagaaagg gaatcattat 1240381 ttatcagaaa gtatatcaat cgatgccgct tcttcttgac tatatcaaca atcataaaaa 1240441 aagcgagaaa atcaaaggaa tcattgggat tacaatgctt gacaaaggtg tggaaaggct 1240501 cggctttgat gtgatcaccc cggtgaaccc tttttacaga tgctttaaaa aagtgtctca 1240561 tgtgccgatt ttatatttga cttcaaagcc tgtgagcttg cggcatttac cgaattcatc 1240621 ctatttgttt atctcaaaag aaaagctgca gaaaacctat caaaaaaaag actgatgcct 1240681 cggtcagcac agtctttttt gattaaatct gatgaaatgt cacttcaggg cggcttccga 1240741 cacggatatt tacgccggtt tgtcccaagc cctcgctgat ataaaatggt ttatcgtgat 1240801 gataatgaag gcctttaatc atgttcattc gcacgagctt tcccattttc accaaatgat 1240861 acggttttgg ccagtgaatt tgcccgccgt gaaaatgccc tgacagcagg taatcataat 1240921 gaacatcttt catatccaga ataatatttg ggtcatgtgt taagacaaga tgatagccat 1240981 tttccagact ttgataagag ccggtgatat tactccgatt cgtactgtaa tcatcaatgc 1241041 cgataatatt gactggtcct gcagccgtct cgattcgaac atgttcattt tgcagcgtga 1241101 tacagccgtt ttcctctaaa actcgcttca atctctgaaa gtcctcttct ttcaatacat 1241161 aatcgtggtt accgaacacc gcgtacattc catatgcagg ctttagcttt tgcaaggcgt 1241221 tcaagtaacc tgccagtttc ggaatattac gtttccgatc aagaaaatcc ccggtaagag 1241281 caatgatgtc cacaggctga tcttttgtta aatgatacag ctcctcaggt gagactgaaa 1241341 tgttttccaa gtgaagatca gataaatgaa ggatatttaa tttttttctg gctggaaggc 1241401 cgtctttttg gtcgattgaa atggtgttga ctttcacatc ttttgtattg cggttcgctt 1241461 tatatagaaa tggcacaaat acgagtatgg ccaatgaaag taagattgta aacaaaatat 1241521 atcccctccc ttctatcagt atagtaagtg atcaagccct atggatagcg ggaattaatg 1241581 ggtagagaca ggttgaaaaa cggattgtca tatgatgaat gatttggaag ggaaaaggga 1241641 taataaattt tgacacatga ggcagaacat gccgacggag tcagaataac aaatggatgt 1241701 gtaagcaatg ttacgattga tgagacaaca aaaaaaagaa acatattatc tctggatcgc 1241761 attatttctt cttttattgt atgtatcccc gctttttatt ttaaaggaag atgcccatat 1241821 ccgggtccac gataatttag attccaacat cgcttggtac aaggttctgg ccgatagcgg 1241881 agaaatcgtc ggcaaggttg acgctgccat tccgcaaatc attaacgggc tgccccggga 1241941 tgcctttggc accgagtgga gcggaattgt ttggctccat gctttctttt cttccatgac 1242001 cgcctatgca ataagccaga cggttacaag agttgtcgct ttttttggaa tgtatgtgct 1242061 gctgaagaaa catataatcc cggaaccaaa agcggctttc atccgaattg gcgtatcgct 1242121 tgcatttgcc ttaacaccgt tctggccttc gggaatgctg agtacgcttg ggtacccttt 1242181 ggcactgtgg gcttttttaa atatccgaaa aggggatatc tcatggagag agtggctgac 1242241 gctgggcttg ctccctctat actcaagctt tgttctaggc ttcttctttt tcctggcagg 1242301 gatggcgtgt ttttggctgt atgatgccat tacaaaaaga agatggaatt tgatgttctt 1242361 aggcagtatt gcatttatga cgagtatcta tcttttcgtt gaatatcggc ttgtctattc 1242421 gatgctgttt gagcacgcac cgatgcatcg tatcgaattt atctcatcta ggcatgacgt 1242481 ttggcattct cttcgactat ccataaaaaa ctttgtctat ggccataatc atgtgatgac 1242541 cgttcatacc gttgtcatcc ttccgatcct gatggtcgta tttgctgctc tgctgttcaa 1242601 acgaaatcgg acaaagccag aaaatgttta tctgttttta tgtgtgctta attacgggtt 1242661 gtcattatgg tatgcgtttt ggttcaacaa aatttgggct gttccaaagc agaaatttgc 1242721 ttttttagca gaatttaatt ttgcccgttt tcattttctt cggccgcttg ttatatacgt 1242781 gagctttgcg cttgctttat atctcatttg gcggatgggg aaaggatgga aatggcttgt 1242841 gtacgccgca gtcgctgcac agctgatggt gttggcgcct tttaatgaag aatatacgta 1242901 tggtgttcat tacaacgcgc cgacattcag ggagttttat gcatcagagc aattcaaaga 1242961 gattaaggaa tatatcggac gtccgcaaga ttcgtatagg gtggcgagca tcggactgca 1243021 tccgtctatc gcccaatata acgggtttta tacgttagat acgtataaca atctgtatcc 1243081 gctctcatat aaatatgaat ttagaaaaat catcgaaaaa gagctggaaa aaaattctcg 1243141 gctgaaacaa tactttgatg aatggggcag ccgctgctac ctttttgtcg atgaactcgg 1243201 taaacgatat gatttcaaaa agaactcgaa gaaaacgatc aacaaccttc aattaaatac 1243261 agatgtattt aaaaaaatgg gtggacggta cattttttct tcagttccga tcatgaatgc 1243321 tgaacaaaac catctcgcgc tcgtaaagac gtttgaccat aaagattccg cctggcgcat 1243381 ttatttatat gaaacaagat aaggaggata tcgattgaaa cagtcacagc cagtattaac 1243441 catcgtcgtc ccgtgtttca atgaagagga agtgtttcaa gaaacaagcc atcagctgac 1243501 agaggttgta gatgatttaa ttgaagaaaa attaattgct gaagacagta aaattctgtt 1243561 tgtcgatgat ggcagcaaag accgcacttg ggctttgatt gctatggaga gcataagaaa 1243621 caagaaggtt accggcttaa aattagcctg caatgtcggc caccaaaaag cgcttttagc 1243681 cggattgcat aaagcgaaga ataggtcaga ctgcgtcatt tcgatcgatg ctgatcttca 1243741 ggacgacatc tctgtgatcc gggattttat gctgaaatat catgagggct gcgagatcgt 1243801 ttacggtgta cgccggagca gaaaaaccga tacctttttc aagcgcacga ccgcgttagg 1243861 gttttatcgt ctcatgaata aacttgggat taaattaatt tataatcatg ctgattttcg 1243921 tttaatgaat aaaaggtccc ttgaagagct tgagcgttat ccggaagcga atctgttttt 1243981 aagaggtatt gtccccatga tcggctttaa atcggccgaa gttttgtatg accgcaagga 1244041 acgctttgcc ggcaaaacga aatatccgct gaaaaagatg ctatccttcg cttttaacgg 1244101 gattacttca ttcagtgtcg caccaattcg attctttacg cttttagggt ttgttttgtt 1244161 tttcctcagc gctgtggcag ggattggcgc gtttattcaa aagctgctcg gccatacgaa 1244221 tgcaggctgg gcgtctctta tcatatccat ttggtttttg ggcgggctgc aattgatggg 1244281 aattggaatc atcggagagt atattggaac gattttttct gaagtgaaaa gacggccgaa 1244341 atacgcgatt gatattgatt tgtataatga acagctgagc ccgcttcagc gccaggaaaa 1244401 agagcggtta gaaaaaaagt acagttaaac acggaaagag ctgacttcat tagtcagctc 1244461 tttttcttca actgatgcaa tatagcgcta agcggttcgt cttgcgggtt gcggtaaaaa 1244521 tcaaaaaatg ggcagccctg cttcttaatt cgatcgatga ccgtatcaat tgtaaacaga 1244581 gcgggtgtta aagatgattg cacctcatgc cagtagagcg gggctgcaac agtcccaagc 1244641 tcatttcctc tcgttgaata gggacagata atcgtttttc cttctgcatg ctgcaaataa 1244701 tcaagataca atttgcagtg tctgttttta atcaagcgtt cagtggtaaa gagctcggga 1244761 aatgcattgg tgcagtactc tgcgatcagc tgcgtaaatt ggcgtgtttc ttcatacgta 1244821 aatgcctcgg gagacaaggg aatataaagc tggatgcctt tgttgccgga cagcttcggg 1244881 tacgatgtga tgccaaagga atccaacagc cgcttcagtt catttgcggc ctgcacggcc 1244941 ataagaaagt catctcgcga aggcgggtct aaatcaatga caatctcagc cggacgcctg 1245001 cttttaatgg tttgaaaagg aacgtgaaac tccaaagcaa gctggttgca aagccatagc 1245061 aatgtagaca tatcctcaca gacaatatgt tcatggcttc catcatagaa agactgaaca 1245121 aaatccggcg catagtccgg cttgtttttt tggaaaaatg attcgctcct agatccatgc 1245181 ggatagcgga tgacggtgac agcccggttt ttcagaaatg ggagcaggta gtcactgact 1245241 tcaatcatat actgaataaa atcttctttt gtttttttat tcttttcaaa tatgatttta 1245301 tccaggcttg tgaactggag ctttgggtga accggtttgg agtgtcgtat gacttgcgca 1245361 tacgtgcatt cggtccagtc catttggaat tcgaaaccga taaacgatac ctctcttaat 1245421 gtgccttgga gaattgttaa gtattgaaca gctgcacaaa tcgaaggttc aagcgtaaat 1245481 tcgcctgagg gtgtttgatg tccgtgctgt tccataatct cgcgtatagc gcttttttcc 1245541 tcatcacgca ttccgtgcga gacagaggca atcggtgtca ttattccgtt ttttaacacc 1245601 gataccgtca gaaacccgtt gttagggttg aaccctgtta tgcaaacata agcttgttta 1245661 aagtttttat atttgagcca atcggacgac cgcttctttt caagccattt gctgtttgtt 1245721 ttcttcgcta caattccttc tccgtcatat tttattacca tctcccagag ttgatcaaaa 1245781 tgatcataac agggaatgga ttgaatggtt tcttttgcgt aaggatctgg agatgcagga 1245841 agctttgctg cggatatgag ttcacgcagc gattttttgc ggtccaaata cgaaagaagc 1245901 gttacatctt ctccgcttcg ctctaacaaa tcaaaggcga gaaagcagca cggccgcgcg 1245961 tttgccgatt cctgaatctt gtctggcctt ttcaaacgcc cccgcacttg aaggtgttca 1246021 aaatctgcac gacagggatt caccaaacat acgatttcac cgtcaagtgt cagcggaagc 1246081 tctttttcta ggtgctgaaa ggcagttttg gcgaattgtg tgatttcagg gaaggtgctg 1246141 ctgagctcca caccatttct gctggttaag gtcacacctg aagaatggat gcggagaata 1246201 cagcggtacc catcatattt tacttcgtaa cgccattctg ctccgattgg cggtgacgaa 1246261 gttaagaccg gctgcatggt aaacgccatg cgctatgatg tgccggaggc tttttttcta 1246321 gttgtttttt gttttttatc tccggctcct ttcggttcag cggcttgtgc aggtgcggca 1246381 gccggtgtct cccggttcgg ccttctggtt ctgtcgatgc tggcttgcag agcgcttacc 1246441 aggtcaatga catcttcacg aggtggcgct ttatcaggag tgacagccgt ttctttattt 1246501 tctagcttgt cgttgactct ttgcagcagc gcctgtcggt acgtgtcttc atatttctca 1246561 ggctcaaact tagcagtcag ttcatctatt aatgtgatag cagtttgcag ttccttatcg 1246621 tttacattcg attgatcagg tacacctggg acttgagcgg cgcttctgac ctcatcggga 1246681 taatggatag actccatgac gatacaattt tcataaacgc ggagaatcgc cagctgctgc 1246741 tttgacctga ttgtcatatt ggcgataccg atctttccgg ttgagcgcag cgcctcacgc 1246801 agcagggtat aggccttcgt cccattatcc ccggggccga caaagtagga gcggttaaaa 1246861 taaatcggat caatttcctg aagctgaaca aagtcaacaa tctcaactgc tttctcctca 1246921 tgctcctgtt ttaagctttt taaatcttcg tctgtcagca ctacatattt tccttttaca 1246981 tattcatatc ccttcacaat ttcatcagga ctaagagttt tttcgcaatt tgtgcaaact 1247041 ttctcgtatt tgattggtgc gtgatcctct ttatggaggc tgcgcagttt aatatcttta 1247101 tcttctgtgg ccgcatatag cttgatgggg atgtttacta atccgaagct gatcgatccc 1247161 ttccacattg tatgcatatc gataaacccc tttttttctt tagtgtgaag agaaggagta 1247221 cgattcatgt gtagtaactt atgggtgaaa aaaagccggc gctgttattg cgacggctgt 1247281 tcaataatga attgttcgaa ttgttccgga ggtattggcc tgctgaaaaa gaagccctgc 1247341 aaatggtcgc agcctttttc aaaaagaagc tgcttttgag ctgcattttc cacaccttcg 1247401 gcaatcacct gcaaagacag ctgatgcccc atggcaataa tagctccggt aatttgctct 1247461 gatttaggat gggtctgaat atcgtcaata aatgatttgt caatcttcag cctgtgaatc 1247521 gggaagtcct tcaaatagct aagagagctg tgaccagtac cgaaatcgtc aatactgatt 1247581 ctgattccta attctgttag ggatgacaaa acctttttgg agtgattgag attgtccatt 1247641 gtcatgcttt ccgtcacctc cacttcaaga agctgcggag gaagctggta cttattaagc 1247701 gtatccttga tgaggggaat cagatcttta gattgaaact gtctggcgga aatattaatg 1247761 gcgacagaaa gatcatagcc tttgtcatgc caaatccttg cctgcttgca tgcttcatct 1247821 ataatccact ttccgatatc aataataagt cccgtttctt ctgcaacacc gatgaattct 1247881 ccgggcggac gcagttgccc gtctggtgtc acaaggcgta tcagtgcttc tgctcctgtc 1247941 attttttgtt ttttcacact gaattgcggc tgataatgca agacaaatct atcgttttcg 1248001 attgcttctc tgagtaccat ctcttggtta agcttaacgg tttctttgtt gccgattgaa 1248061 aaagaatagt atctgtattt gcttttgttt cgttctttag ccgcatacat cgccatatca 1248121 gcctttttca tcaattcaag gccatccgtc ccgtcttttg gagatatcgc aatcccgata 1248181 ctgacagatg tgacaagggt gtgatcttga attttgaaag gttttttgaa tttttggata 1248241 atttttcttg ctaaaacatc tgcttcgcct gttcctgtat tggcgtctgt taatataata 1248301 ataaattcat caccgccaag acgggcgata aatccgttat cagggactac agatgacagg 1248361 cgtttagctg caaactgaag caattgatca ccgacattat gccctaatgc atcgttaatc 1248421 actttaaacc ggtttaagtc aagaaagaat acaacagtgt tataatgcaa ggaatgctcg 1248481 cgattcagca cctttgttag atgagagatg gcatgccttc tgttaggtaa gtctgtaagc 1248541 gaatcataat gagccattct atggatttct ttttctgctt tgtactgctt cgtcatgtct 1248601 ttacaaatga cataaatgct gtctagttcc tgattgacct caacaggtat aagcgtaata 1248661 tttaagtgaa actggccttt ttcagtgata agatcgctat cgctgttcat cgcttgttta 1248721 tcttttttaa cttgctcaaa aaggcgctta accttcagtg atgtgtaatt cctccagtca 1248781 tgcatgctga agccaaattt gctgatcatt tcctcaccag cgtgattgga agatattatg 1248841 tctccttcta atgataaaat aaaaattgca tcaatattgt ggacgattaa agactgaaat 1248901 cgctgttcgt tatcctttat gcgttcgctc tgtttaataa actttcgatc tgcatgggaa 1248961 ctgaataaca ataacgtttg gatacaaaaa ataattaaag taacaaaaat tgaccaatga 1249021 aacgtttgca cctccatatg gcttccgggc ggagccatgt ccttatggaa agttgccgca 1249081 agcatccctg tgtagtgcat gcccgaaatc ccaatgccca ttacaattga actgacgcct 1249141 ttatagaata taagatgctc agaatgtttt tttacggcca agtcaaagaa tatttttaac 1249201 gagacgaaag aggctgcaat cgcaatgata attgaaactg taaataaaat aggttcgtaa 1249261 ataatcatta cccgggaaat ggcagacatt ccgatatagt gcatagaagc aatagatgcg 1249321 ccaagcacaa ctgatccggt aagcagtctg taatatgtaa gaatgtgccg gctgacaaaa 1249381 tataatgaca caaatgatcc cgaaacagat gcgccaatgg ctgccattaa aggcatgaat 1249441 tcatattcca tcggcatttc catatggacg gccatcatcc ctacaaaatg cattgaccaa 1249501 ataccgaatc ccataataag tgagccgccg atcagccaaa ttttactttt taagcctgta 1249561 ttgatggtga ctttccttga aagttcaagg gaaatatacg aggcggtaca ggcaattaga 1249621 atagataaac atatgagagt cgtattatat gtaacgtgta tttccaaatg gagattcccc 1249681 ccgtatcgtg tgttccagtc ttgttgactc tctttattat cggctgctta accgcagagt 1249741 ttcagccttc aaaacgatag aaatacgagg gagatctatt tttagttcaa ctgaccgtga 1249801 aaaatgtgtt aaaatcatct tgatgttttc cgaaaagaga aaaatgtatg atacataaac 1249861 atgaaacaag ggagttggtg gctatcgaag agctggttat gtcatggatt gaagcattta 1249921 aaagcttatc ttattttgga atatttctag cgctcagcat tgagtttatt ccggccgaag 1249981 tcgtcttgcc gcttgcgggc tattgggtat ctaaaggcga tatgacactt gctggcgttg 1250041 ttttggcagg atcgcttgga ggagtggccg gtccgcttac gctgtattgg ataggccggt 1250101 acggaggaag gccgtttctt gaacgttttg ggaagtatct ctttattaaa cctgaagcgc 1250161 ttgataagtc agataatttt ttcaaaaaac atgggggctt tgtcgccttc agcggccgtt 1250221 tcttgcctgg tatcaggaca ttgatttcca taccgtgcgg aattgcaaaa atgaatgttt 1250281 gggtgttttc gctttataca ttcattgcta tgcttccgat tacatttgta tatgtttatc 1250341 tcggtgtgaa gctcggtgaa aattggaagg cagtcggctc tattcttgat caatatatgc 1250401 ttccgatcgg gatagcgatt ttggcgctgt tcctgctcta cttactgatg aaaaagagga 1250461 agaaacgcac gcactccgaa caattatctg tatttttgaa aaataaacgt tgacaaatca 1250521 ctgcgctgcg catattattg acgtataaaa tcatatttct tgaaatccca aaggggagta 1250581 gcgtccggaa tgtattccgg aaacaaagtc gtcatttcat ggattgtatc catcggcttt 1250641 gttggcatgc ctgaattcat gtctagcaag acctttgcct tatgtcggca aaggtctttt 1250701 ttgcatggtc cggccggcat aagatcggat gaagagaaag aaaacaactt ttttgggagg 1250761 gtatcattta tggatgcagc attattatta gagtatggtt gggttcttct cgtcttgatc 1250821 gggctggaag ggattttagc cgccgataac gcgctggtta tggcggtaat ggtaaaacat 1250881 ttgccggagg aaaaaagaaa aaaagcgtta ttttatggat tggcaggggc ttttgttctg 1250941 cgatttggct ctttatttgc aatttctttc ttggtcaacg tatggcaggt tcaagcgatt 1251001 ggcgcgatct atttgctgta tatctcagca agccacttat tgaaaagata tgtatttaag 1251061 aaagaagaca cacataaaga gacgaagcaa agcggttttt ggccgactgt tttaaaagtt 1251121 gaactggcag atatcgcgtt tgctgttgat tccatcttag cagcagtagc gctggcggtt 1251181 acacttcctg ggacatcact cccgaagatc ggcggacttg acggaggaca atttctcgtc 1251241 attttggccg gcggtatcat cggactggtg atcatgcggt ttgcggcttc catgtttgtg 1251301 aagttattaa aggaacgtcc aagcctagaa acagcagcct ttgtgattgt cggctgggtc 1251361 ggagtgaagc ttgctttata tacgcttgcc catcgcgaca tagcggttgt ttctgagcac 1251421 tttatccatt ctggaacatg gaagctgata ttctggggtg tcttagcagc aatcgcggtt 1251481 tgcggctggt ttatgtcagg tgggaaaaaa cagccggagg gtgcacaaaa cgaacaaaaa 1251541 aacagcaccc gtgaacgggc gtaatctgaa agactctgct taaaagcaga gtctttttgt 1251601 gtttgaagcg ttttcataag cgaaataaaa taacattttt ataacatctt tgttacaaaa 1251661 aacacgcata aaaccccctt aattctttag aaaggcacga aatcatgtat agaacgtcag 1251721 aatggtttgt cataattgag acattggaaa tcaatatttc tttttctcct ttgcgaatcc 1251781 ctatcaaatt agctatcatt aatgagtagt tatagggagg aactgaggtg aaaccagtgc 1251841 ttagcctttt gtttaaattg ggaaaaaaga agcaaacact tgaaaaagct gttgagagta 1251901 tacaaaaagg caataaagat ctgcaaaatg aattaataca gcaatataag ccatttatcg 1251961 caaagacggt ttcatccgtt tgtaaacgat atatagatga aaaagacgat gagttcagta 1252021 ttggactgat cgcgtttaat gaagctatag aaaaatattc acctgaaaaa ggaaattctc 1252081 tgctcgcatt tgctgagctt attataaaaa gaaaagtcat tgattacatt agaaaagaag 1252141 ccagaagcgc acaaaatata aatatcgatt tacaggaagg agacgatcag gagtcatcac 1252201 aaagcctgat tgaagccgag ctttccattg atgaataccg ccgtcagatt gaacaggagc 1252261 agaggcggga ggaaatcctc tattttcaaa agcagctcaa ggattatggt ttatcgttta 1252321 aagaactgct tgaaaattct ccaaaacaca cggatgcaag gcaaaacgcc ataaaggtgg 1252381 caatgacgct tgttgaacat gaagaattgg ccgctatcct gtatacaaag aagcagcttc 1252441 cggtcaaaca gcttgaacag cttgtctctg taagccgaaa aacgattgag agaaacagaa 1252501 aatatattat tgcgatgtgt attatcatta cgggtgatta tatttattta aaagattatc 1252561 ttaaaggggt gctgcactca tgagaagagg gattatagta gagaaaaata aaaaattcgt 1252621 cacgttgctg acccctgacg gacaattttt aaaagccaaa aatgatcgac acagctatga 1252681 aatcggagaa gaaatcatgc ttccgagtga aacacgcatg ggcagaaggg ccagcttttt 1252741 tgattttttt aaactgcgcc ctttcaaaat ggggattttt acgatgactg ctattatgct 1252801 ctttattttt atagttctcc ccgttttttc taataataag gcctatgcgt atatgacaat 1252861 cgatatcaat ccaagcgtcg aaatggcgtt aaacagcgat tatgaagtga ttgaactgac 1252921 gcctctaaac gatgagggac agaaagtcgt gaatgatata gatgattggg agaagactga 1252981 ttttaaaaag gtgattgacg atattataac cgactgcagt gaacacgggt atgtaaaaaa 1253041 atcgaaagaa atattgattt ccactgttta tgaaaacaca gaagacaata catataaaaa 1253101 ggctgtgaaa aaacagctga atgatgtgac tgaaaaatat aaaacgacat accgcatgga 1253161 atctctcgag tcagatatgc aaacgaggga aaaagcgaag aaagaaggcg tctcaacagg 1253221 cagctacatc aaatcaaatg aaaagaatga caataaagat ataaaagatg actccagcaa 1253281 accatccggg gaagaggatc aaaagagtga tgaaaatgag gatgaaaaca ccgatcaaac 1253341 tgacacccag gacagcaagc aaggagataa tgaacagctg aatgatgcgg attccggaga 1253401 ccagaaagaa gagaaagcgg atgaccagat tgatgatagt gacaaagata aaaaaataaa 1253461 ggaatcagat gaaaacacaa ataccgaaaa agatggggac catgagcaaa ccccaataca 1253521 agatcctcaa gataaaggaa atgaaaataa cggcgctgac aagggccaaa gccaatatca 1253581 cagggactgg aacaatggtg aacaaggcaa gaaccgttct tcgtccagaa gggataacgc 1253641 ttcagaccga cgtaatccaa acggctacag cagtgataat cattcagcta aaaatgaaga 1253701 ttcgccgagt gcccccggcg aataaagacc tgaatttatt tagttgtgcc atttaattgt 1253761 gattgtgctt gctgtaccag ccgctttgtc atttctccgc ctacagagcc gttagcgcgt 1253821 gcgactgtat cagaaccaag gttcacaccg aattcttgag ccacttcgag tttaaattgg 1253881 tctagtgcct gctccacccc tggaacaacg agtttatttc tgctcgccat ctttttcatc 1253941 tcctttttcg ataaagaaat tcttaacgcg tatttagttt gaaatatacg gggtttattt 1254001 atgctggcaa ttgttgtgga gaaaaataaa accccggcct ctgagccggg gtggcgcaga 1254061 ctatagaatg tctgctgtca ttttatgtgc ggttgcctga atatggaatg tcaaaatgga 1254121 gaggactgta atggcgataa tctgtctgat tttaagccat tggctgtcat tcagttcttc 1254181 aaaacggtga cggagacgct ctgtctcctg ttcggcgatc tcctgcagat ttgattcttt 1254241 catagaagga gtatcttggt gatggatggc atcaagcaca tatgcgcagc tttcataata 1254301 agcaatcggg ctgatgacat catcagatct gtctgagatt gtgttaaagg ccacttttaa 1254361 aatagcccgt atgtgttcaa agtcataaat ggattttaaa tcacgtacaa ttaaaagaat 1254421 aactgcctgt tcaattgagt attttttgcc cagctcaggg tgtccgatca gatctttgat 1254481 atcacgcttt acccagtttt gaatcgcggt tgactttaac gaagtcagct cgcataagtt 1254541 gccaagctct acgatttcat ttgtagacag accgtattct tttttctgtt tttttcgttc 1254601 gtatcttgta agaaattcag gaatttctag atgattggct gctttttctg ctgacatgtt 1254661 cgctgattgg acgagaatgt cgagcgggct atgttctcct tgtcctttta gggaatagag 1254721 cagccgcacc atatcggttc gagagagttt aaaaatgttc attgttcacc tctttaaaca 1254781 atttgacgcg gatataggtc tatgtataag ttcaaaattc aagcgtcagc aaattacatt 1254841 aacatcatac gtcgaattcc ttgcattttc aaatggatgt tttataattt aaatatacgg 1254901 gttcttttga acttaaaata acggaggttg ttatggcgaa aagaattttt ctgtttattc 1254961 taacgaatat tttggtgctt acaacaatcg ggatcgtttt gtctgtttta agctctgtta 1255021 caggagtcgg gacgtacttt acagctgatg gcggtatcga tccaatggcg cttcttgtgt 1255081 tcagtttagt cgttggattt gtcggttcct ttacgtctct tgcgatatcc agatggatgg 1255141 caaagacgat gatgggcgtc agagtgctga atccgaaaaa acactcgctc agctatgagg 1255201 aacagcaatt ggttgatcgt gttcacagat taagccgctc tgccggttta acgaaaatgc 1255261 cggaagtcgg gatttaccgt tcacctgaag taaacgcgtt tgcgactgga ccgtcaaaac 1255321 gccgttcact tgtcgcagta tcgtcagggc tgctggagca gatggatgac gcagcagttg 1255381 aaggtgtgct tgcccacgag gtcgcgcata tcacaaatgg tgatatggta acaatgacgc 1255441 ttttacaagg tatcgttaat acctttgtcg tctttttatc gcgtatcgcc gcttggatag 1255501 caagccgttt tgtcaaagaa gatctagcgc cgatcgttca ttttattgca atgattattt 1255561 ttcagattgt cttttcgata cttggcagcc tggttgtgtt tgcgtattca cgccatcgtg 1255621 aattccatgc tgacagggga ggagcggatc ttgccggcaa ggacaagatg attcatgcgc 1255681 tgcggacgct taaaagctat tcttcccgga ttttggaaga cgatcagaca gctgtccaaa 1255741 cgttaaagat taatggcaag aagcgctctt cacttttctc tactcatcct gatttagatg 1255801 agcgaatcag acggctggaa gctaaataat acaaacacat tgttcctctg agagaattct 1255861 cagaggtttt ttattttatc cattgactaa aatcataaaa aaataagcaa gttaagaaaa 1255921 tgtttcgtaa aagcctttaa aaatggacct aatatcttta gaataattac cgtacttaaa 1255981 aagagaggca gaaggatttt acatgagatt aaagtttgga aaattgatac aggccttgtc 1256041 accggcccag ctgatcgcat tatattattt tcttgcagtt actgtggccg ttatattgct 1256101 gagtttgccg gcggcccata aaccgggggc ggattggacg tttattgatg cgctttttac 1256161 agctgtcagt tcagtcagtg taacggggct gacagttgtt gatacagctg atacattcag 1256221 cacaataggg atttttatat tagcatttgt tctgcaattt ggcggaatcg gaattatgac 1256281 gctcggaacg ttcatttggc tgatcatggg aaaacgaatc gggctgaaag aacggaagct 1256341 gattatggtt gatcaaaacc aatcccagtt ttcaggaatt gtcaatctga tgaagcaggt 1256401 actgtttctg atcttgtgga ttgaattttt tggcgggctg atactcggca catatttctt 1256461 aacctactat gactcctatc aggaagccta tttacacgga ttttttgcca gtatcagtgc 1256521 aacgacaaac ggcggatttg atattaccgg taattcgatg attccatttc gccacgatta 1256581 ctttgtgcag tttattacaa tgcttttaat tatatttgga gcgattggat ttcccgtgct 1256641 tgttgaagta aaggatttcc tgttttcaaa gcatcggcgt tatccattta cgctttttac 1256701 aaagatcacg acgattacgt tcggctcact tgtcttgttt ggagccattg gcatctttgc 1256761 cctggaagca aaccatgcgt tcgcaggaaa atcatggcat gatattttgt ttttgtccct 1256821 gtttcaatca acggcaaccc gaagcggggg gctggcaaca atcgatatca gccaattatc 1256881 agattccaca ctctttttta tttgtgcgct gatgtttatt ggagcgtcgc caagctcagt 1256941 cgggggaggc ataaggacaa cgacttttgc tttgaacctt cttgcgctgt ttcattttgc 1257001 ccgcggcaat aaggccgtaa aggtattcaa acgggagctt caccctgctg acttgatgaa 1257061 gtcgcttgtt gtcacgatga tggcgatcct gctcgttttt ggcgcgacac tcattctgac 1257121 cattacagaa aaacattccc tgctggagct tttgtttgaa gtgtgctcgg cattcggtac 1257181 aaccggccta tcgcttggaa ttacggcaga tttgagcagt gttggaaaat gcgtcattat 1257241 gattgtcatg tttatcgggc gaatcggcat cttgaccttc ctgtatctga tcggaagaaa 1257301 ggaaattgaa gcgaattatc actatccgaa ggaaagagtg attatcggat aggcaaaaca 1257361 ccgcatattt tgcggtgttt tttgattacc aaaaaaaaga tgtgtgcctc ctgttcagtt 1257421 ggagaaccta actccgacag gtgcaattta cgctcctgca tcttaaaatg tctgaaaatt 1257481 ggcgaggagg attcgtatga agcgtaaagc tgaagtgaat gaagccatta aaaataacaa 1257541 tacacctacc gagagcatgg accccaattc atataagaca caatatcatg acgaccccaa 1257601 ttttagaggg gcaaaccgca attccaaaca gggccagcag ggaggcatgt aattgtgaag 1257661 aaaaaccgtc atagcagaga catgcaaaat cataaaaagc ctatgaataa aaaggtgctg 1257721 gaggaagaat tctcaagtga actcggggat tacaatgccg gaaagatcat cgaaacgctg 1257781 gaagtcacca agcctgaaaa gaaaaaagaa aaaaacaaaa aacaacaata aaaaagacct 1257841 cttaggcggc gtcccgctta agaggtgctt tttctatttt aaataagcat ttttgcccgt 1257901 tcctctgaca aattgcaata agcttgtcat cctcagctca atgaatggct gagcgactgt 1257961 cttaacaaag ttgctggaga ggactgatgt cagggctgct gttaaaagca agaggatcac 1258021 taagctttga tagtcagtaa gccaatcctc aagcccgacc tgccgtaatg tcttaataat 1258081 aaacccgtga agcagataca cgtaaaatgt ccgggttccc catttggtaa agaaataccg 1258141 tttttgcgga acgagcgcta aaaagctgaa ggttgcccca aaggcgagta cataccagcc 1258201 gattcgggat agtccgctta ccagggtaac gtctccaaat gaagaatacg gttttgaacc 1258261 aaacagaaaa gaatagtcaa aatcgatgcc ccagcagatg acgaatactg cggcaagcac 1258321 tccgagcgca atttgtttgc cgcgttttga tctcaataaa tcaaaatgat gtttatttaa 1258381 ataaaaaccg acaaggaaca tcggtaagaa tacgaatgtc cgtgacaagc tcagcgtgct 1258441 gctgacaaag tccagataac cgatcagcac ggcgattccg cagctgacaa acagcgccca 1258501 ctgctttgaa agctttgaaa aaggatatag gagcaggttc caaaagaata agcttacaag 1258561 aaaccataac gaccattgcg gatcaatcgg gttcacattt gccatgcttt catcttgcat 1258621 aatgtaataa aagacggaat aaataatttg gaaaatcaaa tacggaataa tcagcttgac 1258681 cgccagcttt tttacatatc ccgcccgttt aaagcctttc gcgaaataac cggatacaag 1258741 aataaatgca ggcatatgga atgtgtaaat gaacttgtag aggtagagca taaaatgatt 1258801 atcattaata aaggaacgaa ggatatgacc gaatacaaca aggaatatca ataaaaattt 1258861 tgcgttatcg aaataactgt cccgcgattt actcatagca tcaccttctc tttcatcagt 1258921 cactaagaga ttattccctg ctggtacata ttttaaaata aaagatgaaa aaggaatcta 1258981 aaaaaatgct gattgttagg tcgatgtaaa gtgacggtaa ggatcgtaga aaatgtcttc 1259041 gtaatgtaat gacgctgaaa ttttctgaaa tttatagggc aaatgaagga agttcccgca 1259101 ttttgtagaa atattgaggg ataggttttg aagaaggagt gtacatgcat ggaaactctt 1259161 ggtgtccaga caaactcgga gctgcgagag gaactgaatc gcctcaaaga agaaaacgcg 1259221 cgactgaaaa aggaattgaa tcagcatcaa gtgattgtca acaatacgct cgatgctatt 1259281 tttatttgtg ataacgaaat gcggattgtt caggcaaatg aagcaacaga aaggatgctt 1259341 caagttgact cggaagattt gaaaaagcgt tctgttttgg attttttgtt ttcaatccca 1259401 aaggatgaac tgaatctttc cgtaaagaag ttttttaaaa aaggctttct gtggaaggag 1259461 gttccgatca ggcttgattg cggggcaaca aaatacatag agtttctggc caaaagaggt 1259521 attggtgagg atttcttttt tgttgtcatg agggacatat cttctaagaa gattctggag 1259581 cgggaattct ctatgaatga acagcttttt aaggacttgt ttgacagagc agttgacgga 1259641 atcgtcctgt ttgataaaga tggcggtttt attgatgcaa atttgtcctt ttgtaaaagc 1259701 tttgaaatca atcataatga gctgtctcat ttatctttgt atgagttcat agacagcggc 1259761 tcacgaaaag atttcgacaa tatctggaag gcgctcaacc gcaagggaaa agcgaagggg 1259821 gagctgcctg tcaagcttcg ttcaggagtt caaaaactat ttgaattcac gattacatca 1259881 aacatcatca gcggttttta tatgtccatt atgagggata tcacagagaa gcggtctatg 1259941 gagctgcagc tctttaaaag tgaggagcgc ttcagagaaa tctttgaaaa tgcaatggac 1260001 gccatcatca tctggtcgaa tgacggaaga atcgtaaaag cgaatcaatc agcctgtaaa 1260061 atttttgagc tgccgatgaa tttgctgttg aaaagaaagc tgtgtgattt tctcgttgac 1260121 tcgcagcaga aatacagcat aacgaagagg aaatacgcaa aatacggaga gatcagagaa 1260181 gagctgctgt ttcaaatggg gaacggccaa ttcaaagagc ttgaatttac ttcaaaacgg 1260241 acaatccttg aaaatcagca tttgacgatc ttaagaaatg taagcgacag aaagcggatg 1260301 gaaaaggagc ttcgggaaag cgagctgaaa ttcagaaaag tgttcaacgg atcaatggac 1260361 ggcaatgtat tgttcgacaa tcaatacagg atcatcgacg ccaacccgtt agcaagccat 1260421 attttgggcc tgtcacatga agagatcaaa cagcacagcc tgttagatat tatttctgct 1260481 tatgaaatag aaaatttggc atcaccggca aggcagatta attttgatga aatggacaac 1260541 gaaattccat ttttgctgag cagcggtgat aacagaaaac tcgaattctc atttaaacgg 1260601 aatattattc aaaatatgaa cttggctatc tttaaagacg taacagagcg aaaagaattg 1260661 gaggagcgcc tgcgcaaatc agataccctt catgttgtcg gcgaactcgc agccggtatt 1260721 gctcatgaaa tcagaaatcc gatgactgct cttaaaggct tcattcagct tctgaaaggg 1260781 agtgtcgagg gagactacgc cctttacttc aacgtgatca cctcagaact aaagcgcatc 1260841 gaatccatca tcaccgaatt cttgatttta gccaagcccc aggccattat gtatgaggaa 1260901 aaacatgtta cccaaattat gagggacacg atagaccttc taaatgcgca agccaatctc 1260961 agcaatgtac aaatgcaact tgatttaatt gacgacattc ccccgattta ctgtgaaccg 1261021 aatcagctga aacaggtttt tatcaatata ttaaaaaacg ccatcgaagt gatgcctgac 1261081 ggcggaaata tttttgtaac gataaaggca ttggatcaag atcatgttct aatctcctta 1261141 aaagacgagg gaatcggaat gacagaagat aaattaaagc gacttggtga accgttttat 1261201 acgacaaagg aacggggaac tggacttggg cttatggtaa gctataaaat tattgaagaa 1261261 catcaaggcg agattatggt agaaagtgaa gaagggaagg gcaccgtttt ccatattacg 1261321 cttcctgtca gacagaatgc tgaagaaaga aggaatgatg aatgaactac tatacgacag 1261381 ccgaaacgcc gctcggtgaa cttatcattg ccgaagagga ggaccggatc actcgtctat 1261441 ttctcagtca ggaagattgg gtggattgga aagaaacggt tcagaatact gagcataagg 1261501 aaacacctaa tcttgcagaa gcgaaacaac agcttcaaga atatttcgca ggcgaaagga 1261561 agacattctc cctgccgctc agccaaaagg gcactccttt tcagcaaaaa gtgtggcaag 1261621 cgctggagag gattccatat ggcgaatccc gaagctatgc ggatattgcc gctgctgtcg 1261681 gcagtccgaa agcggtgcgc gctgtcgggc aggctaataa acgtaacgac ctgccgattt 1261741 ttgtcccgtg ccacagagtg atcggcaaaa acagtgcgtt aacaggatac gccggaagca 1261801 aaacggagat caaagcattt ttgctaaaca tcgagcgaat ctcctataaa gaaaaataaa 1261861 acatatggca cgttcccttt tttcacggcc gacatatcat tttattaagt taaaaaagtt 1261921 ggtctgatga aaaaggagga caaagcaatt gaagccgagc cgctctgaga aacttgccgt 1261981 ttttgccgaa ctgtttgtga aactgcatat cttatcaagc gctcaaaaag atgaaatcat 1262041 caatgttaac aaaaagaaac aaaaaaaccg ctgactcggc tccaaatgag caaagtccag 1262101 cggtttttta atgcaccttt tctcctttaa acagctgttc aatctcttct tcatagtttc 1262161 cggtcataat ccctttttct gtgatgattc ctgaaatgag atcatgaggt gtaatgtcga 1262221 aagcgggatt aaagacaggc acattggatg gagcggtccg aactccggaa atctgcctga 1262281 cttcctcggg atctcgttcc tctatcggga tatcagcgcc gcatttgacc tttgtatcaa 1262341 atgtagataa aggtgcggcg acaaaaaacg gaatatcaaa ggcgtttgct aaaatagcaa 1262401 gaccgtatgt gccgatttta tttgccgtat caccgttctt tgcaattcgg tcggctccga 1262461 cgataacagc ggaaatttgt ttttccttca tcgtatgggc ggccatgctg tctgtgatca 1262521 gagtgacatc aatgcccccc tgcatcagct cccaagcagt aaggcgtgaa ccttgcagga 1262581 caggccttgt ttcacaggca taaatgtgta atcccaaatc tttttgtttg gccaagtaaa 1262641 acggagctag cgccgttcca tagcggcttg tcgcgattga gccggcattg cagatcgtca 1262701 tgatcctgtc gccttttttg aaaagctgca gggcgttttg gccgatcaac cggcacgttt 1262761 cctcatcctc gacctgaatc tgaatggctt catggacaag gtttgttttt gcttcattta 1262821 cggaaatcgc gttttcgacc gaatgactca gtctctcaag cgcccatgac aaattaatgg 1262881 cggtaggccg tgagctgttt aaatattgtt tgatgtcttc cagtctgcgg cggaattccg 1262941 tgacattgtc tgtttcaatg tctttggcag caagcgccag tccgaaggca gctgtaatgc 1263001 cgatcgccgg agcgcccctt actttgagcg tgacaatcgc atcaaataca tcctctttcg 1263061 tcgtcagctc caaatattcc gtctcatcag gaagcttttg ctgatttaaa atggtaatag 1263121 ctgtttcttt ccattcaaca gaacgtggaa cagcaaatga atgggtcatg aatagatcat 1263181 tcctttacaa gtaacttaaa taattcaata acatctgtta tcgttttgaa ttccgaacgt 1263241 ttttcgataa aggctgtgcc ggtttcgagc gccaagcgtt ttctgccgat tcgtttatca 1263301 aacggcacga tcgtatccag gtcagctaca tgggcaaggc cgatcgtgcg tcgtatcagc 1263361 tcacagcccg caaatccgat tgcttcttca aaaatatggc tgagcgtatc agtgaggtaa 1263421 ccgtcgatgt tggcgtaaac atccagactg tccttctgcc aggcttcact aaacgtctct 1263481 tcaaacgttt cccagacctg gttgacatgt tcatataacg gctctctgtc agccccgtca 1263541 cggctgagtg cgttcaaaaa taagttggcg ataaattgcc ctacatcaaa gccgatcggt 1263601 ccgtaaaaag caaactcagg atcaatcacc tttgtttcgt gctcacttgc gaaaatgctt 1263661 cctgtatgca aatcaccatg aatcaacgtt tctgcagacg ttaaaaatga ctttttcagc 1263721 ttagcggctt cgattttaac gctgtcatta ttccaaagct tttcgacaaa aggacgaagc 1263781 tcttcttcaa aatcatttgt gtcatggtcg aagaaaggat ctgtaaaaac aagtctttcc 1263841 gtaatgtcgc atagctctgg atttgtaaac tgtttaacaa gctgtttttt caccttaggt 1263901 tcaagcgcgt aatctgatga gtagaaaagt gtttttccta aaaattcacc gatgtgctgc 1263961 gacagatgag gatagttttc accctcaatg agtccttttc ttgcgatctt gaggtgagag 1264021 agatcctcca tgacggtaac cgccatttcc gtatcagaat aaaacactct tggaaccagg 1264081 tgaggcacat gctcgccctg acggatgaga gcgctgcttt cgattcttgc acggtcgatt 1264141 gtcagcggcc agctttctcc caccactttt gcatacggaa ccgcctgttt aatgatcaat 1264201 gctctgtcat gttcttgatc ataaatatga aaaacgtaat ttaagttgcc gtctccgatc 1264261 tcctggcatg tcagcgtgct tttgcttgga aataggccaa gcttcaccgc caacgccaca 1264321 gcggagcttt catttaacgt ttcgtataaa ggtgtttttg tgactcccat catcataacc 1264381 tccaattatg taattaatta atatgtggcc gtaaaaaagc ctccttctca gagagaagga 1264441 ggcttaacat ctatgtccgc ctctcttatc tctcagatca gatctgaatg gaattagcac 1264501 cgtgccttaa gagaccagcg tctcggcgcg aaaaaaatgc gccccatttc acaatggaat 1264561 tacggtcggt tgcttttggg gtcaaaaggc caaatccctc gcccaactct cgataagaga 1264621 atatattcac ttgtttgaca attctaattt atcagttgat gaacatggta acaggtaatt 1264681 tagttagttg tcaatatatt ttttaatata aatcttttct gatatcatcg aaaacaggaa 1264741 tgctctcccg aacttctgcg ctttcttgaa ggtcgatttc cgctcggact atgccttctt 1264801 cccggccgcc ttcagcaagt acacgtcccc atggatcaat aatcaggcta tgtcctgcaa 1264861 attcattatc cggatttgaa ccggtacaat tgcaggctgc gacaaagcat tggttttcaa 1264921 tggcccgcgc aataagcagg cttttccaat gatcaaggcg gggaagaggc cattccgcag 1264981 aaataaacag cacgttggcg ccttttgtcg tatgttttct gatccattcc ggaaaacgga 1265041 tatcgtaaca gatcaatcca gagcttttga cgccgtcaag ctcaaagtat ccgtcttcgg 1265101 aaccggctga taaatacaga tgctcatcca tcagctgaaa aagatgggct tttctgtact 1265161 ctttaatgat ttgcccttcc ttatccgcga tgtacattgt attataaaca tcagaattct 1265221 tcctgacagc gaccgatccg gcgacaatat gaacaccatg tttttttgcc gttttcttca 1265281 gccagctctg agcggagcgg ccgtcttcgt cagcgagttc atcaagattg gccagatcat 1265341 atccggtcgt ccataattca ggcagaacaa gaacatcagc atgtttgctt tctttttcga 1265401 tgaaaaattc agcctttttt atattttccg aaggttttcc gtatgaaata tcaaattgaa 1265461 gacaagatat cgtccatttc atctttttaa caccccaaat ttttctttac ttttttcatt 1265521 taaccatata tgatgatgga ctatcatttc aagatttttt tagaaggtga gaatagatga 1265581 aatttgaaca gtctcatgta ttgaaggaat tgcctaaaca attcttcgct tctctggtgc 1265641 agaaagtgaa ccgaaagctt gcagaaggac atgacgttat caatctggga cagggaaatc 1265701 cagatcagcc gactcctgag catattgttg aggagatgaa acgagctgtc gctgatcctg 1265761 agaatcataa atattcgtct tttcgcggct cataccgtct gaagtcagcg gctgctgcat 1265821 tttacaaaag agaatacggc attgatctgg atccggaaac cgaagtcgct gtattattcg 1265881 gcggaaaagc cggtctagtc gagctcccgc aatgcttgtt gaatcccggt gatacgattt 1265941 tagttcccga tccgggttat cctgattact ggtcgggtgt cacacttgca aaagcaaaga 1266001 tggaaatgat gccgctcgta aaggacagag cgtttctccc tgattacagc agcataaccg 1266061 ctgaaataag ggaacaggcg aaattgatgt atttgaatta tccgaataat ccgactggag 1266121 ctgttgctac ttccgagttc tttgaagata ccgtgcgttt tgcggctgaa aacggaatct 1266181 gcgtcgttca cgattttgct tacggcgctg taggatttga cggctgcaag cctttaagct 1266241 ttttgcagac tgaaggtgcg aaggatatcg gaattgaaat ttacacgctg tcaaaaacgt 1266301 ataatatggc aggatggcgg gttggctttg ccgtcggaaa cgcttcggtc attgaagcga 1266361 tcaatcttta tcaagaccat atgtttgtca gtcttttcag agcgactcag gaggctgcag 1266421 cagaggcact gttagccgat cagacgtgtg tggcagagca aaatgccagg tatgagagca 1266481 ggagaaacgc ttggatcacg gcatgccggg aaatcggctg ggatgtaaca gctcccgcag 1266541 gttctttttt tgcatggctg cctgtgcctg aaggctatac ttctgagcag ttctcagatc 1266601 ttttgctgga aaaagcgaat gtggcagttg cggctggaaa cggcttcggt gaatatggcg 1266661 agggctacgt cagagtcgga cttttaacaa gtgaagaaag acttaaggaa gccgcttatc 1266721 gaattggcaa actgaacctg tttacccaaa aaagcattga caagacctta taacgatggg 1266781 ataattcaaa ataatttata aaatctatat tttcttatca agagcaggca gagggacgag 1266841 cccgatgaag cccggcaacc gacttataaa gcacggtgct aattcttgca gctagcggct 1266901 gagagataag attcggacga gaaacgaaac ctctttagac gcgattgcag tttgaagagg 1266961 ttttttgata tggatgaaaa tgaaaggagc tctggcatga gtgagttatt agcgacatat 1267021 ctcctgaccg aaccgggagc cgatacagag aagaaagcag aacaaatcgc aacaggattg 1267081 acagtaggct cctggactga tctgcccctt gtaaaacagg agcaaatgca aaagcacaag 1267141 gggcgggtga taaaagttga ggagagagag ggaactgctg catcagaaaa acaagcggtc 1267201 atcacaattg cctatcctga aatcaatttc tctcaggata ttccggcttt gctgacaaca 1267261 gtgtttggca agctgtccct ggacggaaaa atcaaattaa tcgatcttca cttctctgaa 1267321 gcatttaagc gtgcactgcc gggaccgaag tttggcgtat acggcatccg gaagctgctg 1267381 ggagagtttg agagaccgct gttaatgagc atatttaaag gcgtaatcgg aagggacctg 1267441 agtgatatta aagaacagct ccggcagcag gcgcttggcg gagttgactt gattaaagac 1267501 gatgaaattt tctttgagac tggtctagcg ccttttgaaa caagaattgc agaaggaaag 1267561 caaatattga aagaaacgta tgaacaaacc ggacataaaa cgctgtatgc ggtgaatttg 1267621 accggacgta cggctgatct gaaagacaaa gcgagacgcg ccgccgaatt gggagcggat 1267681 gcgcttttgt ttaatgtctt cgcttacggc ttggacgtta tgcaaggcct tgcagaagat 1267741 cctgaaatcc cagttccgat tatggcgcat ccagcagtga gcggagcgtt tacgtcttct 1267801 ccgttttacg gtttttctca cgctctttta ctcggaaaat taaaccgata ttgcggtgct 1267861 gacttcagcc tctttccgtc tccatatggt tcggttgcgc ttccaagagc agatgcactg 1267921 gcgattcatg aagaatgtgt gagagaggat gcttttaacc aaacatttgc tgttccgtca 1267981 gcaggcattc atcccggcat ggttccgcta ttaatgcgtg atttcggcat agaccacatt 1268041 attaacgccg gaggaggcgt acatggacat ccgaacggtg cccaaggcgg ggggcgagcg 1268101 ttcagagcta ttattgatgc ggtcctagag gcccagccga ttgatgaaaa agccgaacaa 1268161 tgcaaggatc ttaagcttgc gctagataaa tggggaaagg ctgaagccgt atgacgactc 1268221 gaaaaccttt tattatttgt gattttgacg gaacaatcac gatgaacgac aacattataa 1268281 atatcatgaa aacatttgct cccccagagt ggatggcatt aaaagacggc gtactttcca 1268341 aaacgctgtc aatcaaggaa ggtgtcgggc ggatgttcgg ccttctgccc agcagtttaa 1268401 aagaagagat tacaagtttt gtattggaag atgcaaaaat cagggaaggc tttcgggaat 1268461 ttgtagcatt tatcaatgag cacgagattc cgttttatgt cataagcggt ggaatggact 1268521 tttttgtata tcctttgctt gaaggcattg tggagaaaga ccgcatttat tgcaaccatg 1268581 cttcatttga caatgactat atccatattg actggcctca ttcctgcaag ggcacatgca 1268641 gcaatcaatg cgggtgctgt aagccgtcgg tcatccatga actttctgaa ccgaaccaat 1268701 atatcatcat gatcggtgat tcggttacag atgtggaggc agcaaagctg tctgacctat 1268761 gctttgcaag ggattattta ttaaacgaat gccgggagca aaacctcaat catcttccgt 1268821 atcaagattt ttatgagatc agaaaggaaa ttgagaatgt aaaggaggta caggaatggc 1268881 tgcaaaacaa gaacgctggc gagagctcgc tgaagtaaaa cgggaattgg cagagagaga 1268941 ttggtttccg gcgactagcg gcaatctgtc aattaaggtt acagatgagc ctttaacatt 1269001 tctcgtcact gcaagcggaa aagataaacg caaagagacg gttgaagatt ttctgctggt 1269061 cgatcaaaac ggagagcctg ctgaaagcgg gcattctctg aaaccgtcag cagaaacgct 1269121 tttgcataca catttgtaca ataaaaccaa tgccggatgc tgcctgcatg tccatacggt 1269181 aaacaataat gtgatttcag agttatacgg agaccaaaag aaaatcacat tcaaaggcca 1269241 ggaaattata aaagcactcg gcttgtggga agagaacgca gaagtgaccg ttccgattat 1269301 agaaaatccg gcacatatcc cgacgctagc ggcactgttt gcggaagaga tttcagaaga 1269361 ttcaggagct gttctgatcc gaaatcatgg tattacggct tgggggaaaa cagcatttga 1269421 ggcaaaaaga gtgcttgaag cgtatgaatt tttgttcagc taccatttga aattgaaaac 1269481 actcgagcat cagctggtta aataaaagga ggaattgaaa tggctacaat tcgaattcat 1269541 gatgaggcaa atacaacgat tgaaaatcaa gaggaagtgg caagctttct ggacagtcaa 1269601 gaggttattt atgagcaatg ggatatcacg aggcttccgg aacatctctc agagaaatat 1269661 gacctgacag aagaagaaaa acagcaaatt cttgatacct tcgaaactga aattaaagat 1269721 atctcaaccc gccgcggcta taaagcacag gatgttattt cattgtcaga cagcaatccg 1269781 aaacttgatg aactgcttga aaactttaaa agagagcatc accatacaga cgatgaggtt 1269841 cgttttattg taagcggaca cggtattttt gtcattcaag gccaggacgg cacgtttttt 1269901 gatgtccgtt taaaccctgg agatttaatc tccgtgcctg agaatatccg ccattacttc 1269961 acgcttcagg aggaccgcaa agttgtcgcg gtgagaattt ttgtcacaac tgaaggctgg 1270021 gttcctattt atgaaaaaga cagcgtgaat caataagcgt gagatagccc cgttcatcga 1270081 acggggcttt ttatatttat tgcaaacgcc acttttcata ttgtgacagt tcttttttaa 1270141 tcagtgtcca aatcaaacct aaaacagctg catcgtcaat gaatccaaga ccgaggatta 1270201 cgtctggaat gatatcgagc ggcatgacga tatacaggat tgcggcagtt aacagcaaaa 1270261 gtgttttaac ctgtgaacga gggtagtcgc catttcgcca atcgcgaagc atctgaaaaa 1270321 aagtagtgat gtgctggata catttttttc ggtttttcct ctttaaaatc gcttttccgc 1270381 ctgccgctcc gagcattatt gctttctttt tcttcattgg gcatacctcc tgcctggcgg 1270441 cgtgtttaag atattcttca cctgggtatt gttcttctaa tcctatcaat atatctatta 1270501 tacctgaaaa attaacttat ttaatgaaaa tatgtttaca aataaagtat aatctgtaat 1270561 aatgcacaat aacccaatca aacttgtttc ctatttctta gcggcgaggg gtgaagtgaa 1270621 tgggcggttc ttctgaacaa gaaagattgt tggtgtctat tgatgaaaaa agaaagttaa 1270681 tgatagatgc cgctagaaag cagggattta cagggcatga cacgatcagg cacagtcagg 1270741 agctggattg tttaataaat gaatatcatc agcttatgca agaaaacgaa cattcccaag 1270801 ggattcaagg ccttgtaaag aaattaggct tgtggccccg cagagatgtt atgccagcat 1270861 atgatgcaaa taaatagcgg cctatcagat gcatatataa agagagagct tttcggaagc 1270921 gctctttttt tctggaaaaa attcatatga aagagggaac taatgaagga actggcgatt 1270981 ctcattaccg aaatggtcaa tcaatttcat gatgctttta tttccttatg cggaatattt 1271041 ggcattcatt taactgacaa agaaatgcat ttttgggtga tcggcatttt tggcatattc 1271101 tttttcggcg tcactcacgc tgtgtttaca tggctttcta aatggagtat gacagccttg 1271161 tcctttatct ataccgttac agtcatcatt gtcatcgtat ttgcgattga gattcagcaa 1271221 aaggtgacgg ggagagggaa tatggagttt ttagatgcca cggaaggtat aaagggtttt 1271281 ttagtatttt ttatgttttt tttgcttttg aaaatgctgt tgcgtttcat caaaatcctt 1271341 ttttctggaa gaccagcaag caaatcgaat ggcaatgccc gatcacgaag ataaaaaacc 1271401 ctcctgacat ggtcaggggg gctatgatgc ggatacgggg agggtgatcg tcacctctgt 1271461 gcctcttcgc acttcacttt caatatgaat agagcctccg tacatcagca cgatccgttt 1271521 acaaacaaca aggccgagac cggttccttt ttctttagaa gtaacaaagg gaaggaagat 1271581 gtgatccagc atttcctgag aaatcccttc accgttatcc acaactttga ttatggcttt 1271641 tttatctaaa gctcctaggg agatcgtcag tttgcctcct tcaggcattg actcgaggcc 1271701 attttttgct acatttaaaa tcacttgttt aatatgatct tttgtacatt ttacgagtaa 1271761 gggctgctcg gttagatact gtaattcgac ttcaacattg tatagattgc cctcagaata 1271821 aatgatcggc ataatttctc cgataatgtc ctgaagtgag ttcagctccc atttttcagc 1271881 tgtcggcttg ccgagaacga gaaactcact cactatttga ttgatgcgct ttatctcctg 1271941 ttcgataatg gagaagtaaa gctgatcttc ctcaccttta tatttctttt gcaacagctg 1272001 aataaagccg cttatcccgg tgagggggtt acggatttca tgggctgtgc tggcagcaag 1272061 cgtcccgatc agctctaatt tttgcgcctc gttttctgag cgctccagct gggtctgccg 1272121 cttcagcaaa taatacagca cgagaataaa aaggatattc agcagaacaa taatacatga 1272181 aagcggaagc acaaggcttt tcgacagttc ttctattgtg accgggttcg gatagacttt 1272241 catattccag ctgatatcat ccagatatcc gctgacaggt ttctgatcct ctgcatgaga 1272301 ggcttgtccg ctcgcaaaaa tcattttccc gtcttggttc acaacttcaa tataaacatc 1272361 agggcttagt aagttaatga gatttttcaa ataatcaatt tgaatagctg cgacaagata 1272421 atctgtcaca ttacgttttg agtccaaaac aggcacacaa attgtgaaaa ttggctgacc 1272481 agtaattctg ctcgaataac tatctgaaat gactgtcttt ttagtttcct ttgcttttat 1272541 aaaaaaagat ctgtcggcca ggtttacttt cgtttttaat tcggttgtgc ttgcggtgac 1272601 gtctcctttg gcattgagaa aatagagacc ggaaaatctc ggctctgaat caaaggtctt 1272661 ttccaaaatt gattgcattt tctttatatc aaccggtctg tcgatggcga tggacaagga 1272721 ggtcattctc gccattgttt ctccgattaa ataattgatt ttgttgcggt gaaggtttag 1272781 caggacactt gcttcttgtt tatgttctgc agctattgta tctttttctt tttcatatac 1272841 gaaaaagctg atgacgattg ccggaatcac gaccagtatg atataaagtt tgactctccc 1272901 gcaggcgcct tttagtattt tcaatttgca tcgctccaac atacacctga ttagaggtat 1272961 tatatcattg tttcttcttc tttaataaga aaaaataacc aaaaaaatta gaaaaagatg 1273021 ttggcaagct tacattttaa aaaagaagag aaatattgga aagattttta ttgacatttt 1273081 ggtctttgtt tattaatgtt tctctgtaac ggtttctaaa aggatgattg agacatgaca 1273141 gaaaaatcac tgaagttatt tatcgtgctg tcgcgcgcgt atcggtctat taacgatcat 1273201 atgaataagc atattcataa gcatgggctg aatccgactg aatttgctgt gctagagctt 1273261 ttgtaccata aaggcgatca gccgctgcag cagataggag ataaaattct cttggctagc 1273321 gggagcatca catacgttgt agataagctg gagcaaaaag aacttctcat tcggaaagcg 1273381 tctcctacag acagacgagt gacatttgcg caaattactg aaaaaggcat cggtcttttg 1273441 aacgatattt tccctgatca cgctgctgaa attgatgaaa tgatcagcgt attaagcgaa 1273501 gaagaggtag agatgtgcac cgaaatgtta aaaagagtag gattaaacgc aaaacagttt 1273561 cataataagt aaaaaaagga agcctgatat gtcacaaggc ttcctttttt gctatttttc 1273621 atttgtttcc gctgcgcctc tcggcaaaat gagaacttca acccgccggt ttttgcttcg 1273681 gccttccgca gttttattgg aagccaccgg tttatactcg ccataaccct tggcgctgaa 1273741 cacttttgca tcgagcttgg ggttttcaat caggagcccc ataaagttta ccgctctcat 1273801 gacgcttaaa tgccagtttg attggaattc agaattttta attggcatat tatcagtatg 1273861 tccgctgata atgatatttc ttggcgggtt aatcacaaga agatttgaaa tctcttttgc 1273921 aagcggcaca tcttccttac ggatggtcgc ttttccagaa tcgaagaaga tgctgtcttt 1273981 aatcgtaatc agaaggcctt cactagtcat cttcgtctcc agctgatgtt ccagcttttt 1274041 atctttgatg aacttttcca cctggctctt cacattttca agttcttctt gatcagctgc 1274101 tttttctttt tctttcttgt ttttctcttt ctcttctttt tcctttttca cttcatcgat 1274161 gccgtctgac tcgttttcag gaggagtgac actggagtag tccagtacac cggttccgcc 1274221 tgtaaaaact tcattaaatg attttgagag catttgaaac ttagctgcgt caatcgagct 1274281 gctcgcgtac agcacaataa acaatgccag gagaagagta aggatgtcgg cgtaaggaac 1274341 gagccatgat tcatcaacgt gctcgtcctc atgcttcttc ttcttttttc tcgccatttt 1274401 gcgcctctcc ttgttctgca aatttcaagc ggtccttcgc aggaagatac attaaaagct 1274461 tttgttcgat gactttcggt gcttgtcctt ctaaaacgga taaaacacct tcaatcatga 1274521 cctcacgcag ttttacttcc tgttttgatt ttcgttttaa tttatttgcg aaaggatgcc 1274581 ataacacata ccctgtaaag ataccgagaa gtgtggcaac aaaggcagca ctgatggcgt 1274641 gtccaagctc atctgtgtta tccatatgag agagagcggc aatcagcccg attacagcgc 1274701 cgagtactcc aagtgtcgga gcgtacgttc ctgcttgtgt aaaaatagcg gctcctgctt 1274761 ggtgcctgtc ctccattgct tcgacttcct ctgtcataat atctcttata aattccgcgc 1274821 tttgcccgtc aacagccatg ctgagcccgt ttttcaagaa agcatcatct acatcctcaa 1274881 tgcttgcttc taaagcaagc agaccttcgc ggcgtgcaag ctgagcccat tcagagaaca 1274941 taggaatgag ttcctctatt gtgagctgtt tattttcctt aaataacact cgaaacagcg 1275001 taggcacttt tttaatttct tttgttggga acgcaataac gactgctgag attgtcccgg 1275061 cgataataat taaaatggca gcggggtttg caagggcgct gaaactgacg cctttcagaa 1275121 ccatcccgac gctcaatgcc acaaaagcaa gaataatacc gattaacgaa gttttatcca 1275181 tagttttcac caaatccttt tttactagct tgtctatggt taatatcggt tttggtgccc 1275241 ggaactttag ggacattgtg aatttgttca tgaaatattc aaggaagagg catagaaggg 1275301 agaaataaac aaaaacgggc tctccaaaat tgaaaagccc gggggtctac tgaaattagc 1275361 agcttgcttg caagctgtcc ttcagatggt attcatataa tagtagaaat acatattcac 1275421 tgtatataaa catgttccat ccctccttaa aaaagtgtaa aggatgaagg gaagtagcgc 1275481 ttcaggagaa gggacggtaa tttctaagtc aagagtatga aagtataaaa aaaagcggct 1275541 tcctaaaagg aaaccgctga ttgttatttt gctcgcactt tgattttatc atcttctaaa 1275601 atcacgtgaa aacttgtgat ctcgccatta tcaagcagca gatcggtcat ttcatcctca 1275661 acccattctt ggatggttct tctaagcgga cgtgcaccga atgaagggtg gtagcccagc 1275721 tcagcgattt tttctttcgc ttcatctgtc acattcaagc taatgccccg ttccgccaat 1275781 gtttcttcaa gttctccaag aagaaggctg acgattttga caagatgttc tttttccaat 1275841 gagcggaact caataatgct gtcaaaacgg ttgaggaact caggtttaaa gaacatgctc 1275901 agtgaatcaa ttaatgtttg ttcttcgatg acactgtcat ctgattggaa accgactttc 1275961 gtttgtttct caccagcacc cgcattactt gtcatgatga tcacagtgtc tttgaagctt 1276021 acagttctgc cttggctgtc tgtcagacgg ccatcttcca taatttgcag gaacatatgc 1276081 tgaacgtctg ggtgtgcttt ttcaatctca tccagcaaca caatgctgta aggattgcgg 1276141 cgcaccttct cagttaattg tccagcttcc tcatggccga catatccagg cggtgaaccg 1276201 ataattttag atacggcgtg tttctccatg tattcgctca tatcgagtcg gataatagcg 1276261 tcttttgtgc cgaataattc atctgccagt gttttagaaa gctctgtttt ccctacgccg 1276321 gtaggaccga cgaagaggaa ggagccgact ggtctgtttt tggattttaa tccggcgcgg 1276381 cttcgtctta ccgcttttgc cactttttga acagcggctt cttgtccgat cacgcgttca 1276441 tgaagttttg cttcgagttc tttcattttc gtttgttcgt ctgcctgcag tttgccgaca 1276501 gggatgcctg ttttttgttc aacaatttcc tgaatgtgct cagcttccac agtgacagcg 1276561 gtatgagcgg aggagctgtt cagttttttc tccaatgcga gttcttcatc acggagtttt 1276621 gccgccagtt cgtaattttc ttcttccagg gcttttgttt tttcggcttc aattgcagtt 1276681 aagcgttcag cggcatcctc atcattcagt tcatcaatta acaggttggc ttttgaacct 1276741 gcttcatcta ataaatcaat tgctttatcc ggcaggtgtc tgtcctgaat gtagcgggat 1276801 gataaagtga cacatgcttt gattgcttca tcactgaatg ttacgccatg gtacgcctcg 1276861 tatttgtctt taatcccttg cagaatgagg atagcctgtt caattgaagg ctcctgcacc 1276921 atgacaggct gaaaacgtct ttccagcgcg gcatcttttt cgatttgacg atattctttc 1276981 agtgttgtcg cgccaatgac ttgcagttcg cctctggcta gggccggttt gagaatgttg 1277041 ccggcgtcca ttgatccttc tgcagagcct gcgccgacga gaaggtgaat ttcatcaatg 1277101 aacagaatga cattttttcg ttccttcagc tcagtgatca gctgtttcat tctctcctca 1277161 aattggcctc tgatccctgt gtttgcaaca agagatgcaa catcaagcaa gtatagctct 1277221 ttgtttttta gtttgtttgg aacatcacct tcagcaattt ttaaagcgag cccttcagcg 1277281 atggcagttt tccctacacc cggctcacca ataagaaccg gattgttttt gtttcggcgg 1277341 tttagaattt cgatcactcg cgccacttca tcatcacggc cgatgacggg atcaatgaga 1277401 ccggcttttg caccgtttgt aatattttga gccagctcat caagcaaccc ttttttttcg 1277461 ctttgttttg ctgcgctctg ttctttcggc tggaatgcct gttcaaacgg aaatccgaaa 1277521 gattgaggac ccatactcat tgaaggttta cgggtcagtt cgttatagca agtttcacaa 1277581 agaaccatct gtttatgaac ggaatttatt tgcatgttaa ggcgaatcgt cgcctcgttt 1277641 tgatgacaat gttgacaacg catttgccaa aacctcctta ataatttgat catctttgac 1277701 caatgaaagt gaataaaaag gtctattggg tttgaccttc tttgactatt agtatacggc 1277761 aaacttaacg gcattcaaac caatatgctc aaagcagact gaatatttga ctatctttga 1277821 ccaattgatt tttaaaaaag gccggtttgt ttgaccaact ttgattaata gtatactctg 1277881 actatctttg actttcaagt cttatgcaca aaaatttttg atttgttaca aagtaaaaca 1277941 tgttttcttc gtcttttcaa ggaacttgtc tcataggtta taaaaaggca tatatggaca 1278001 aaactgcggt tcgttcggag ggaagaaatg gaacaatcaa aagggtctgc aagtcagctt 1278061 gcttttgtgt atgtcggcac agtagtcgga gctggatttg cgactgggag ggaaattgtt 1278121 gagttttttc tgaagttcgg ctggttcggt tttttcggca ttctcgtcag cggcggaatg 1278181 tttacgttac tgggggccaa gctgatgatc atttcaaagc gaatcaatgc caagtcatat 1278241 caagaaatga acatattttt gttcggggcg acggctgggc ggattatcaa tgtatttatg 1278301 ctgtttgttc tccttggagt tacatctgtt atgctttcag gggcaggggc gctttttgag 1278361 gaacagctgg ggatgtccgc tcagattggg atgctcatta caatcggtct gagtttaatt 1278421 gtgatgacta gaggagtaaa aggcattttc ggtgtcaatg tgtttgttgt tcctctttta 1278481 atcatctttt caatgattgt ggtggccgac tcttttatat tcagcgaatc acgaaacgca 1278541 gctcagtggg tctggccgca tcgctgggat tggctgttat cagcagtttc ttacggggct 1278601 ttaaatttat cgcttgccca agctgttttg gttccgctgg cgaatgaaat gtcatcggag 1278661 aaagtgataa aaaaaggcgc tttaatcgga ggcacgatgc tgacgattgt gctgtccgcg 1278721 agttttctgt ctttgtcgac tcttccggat gtatttttgt atgatatacc gatggcgcaa 1278781 gtggtttatc tctttgcacg atctgtccat ttgatttatt tactcattat tttcggagaa 1278841 gtgttcacat cagttatcgg taatctatat ggattagaaa aacaagtgca aagctttctt 1278901 ccagtgaaaa gcaaatatat ctttgcagcc attatgatca cggcttatat tacgagccaa 1278961 atagggtacg gcaggcttat ttcaacgatt tatcccttgt ttggctatgt gagcctggcc 1279021 ttcataggcg ctttgctttg caaaaaagct cctcggcggc gcagtttata aatatatata 1279081 atgaaacgaa ccgtcactat agagcgataa ttgatctagg aaccggggac tgactttttt 1279141 attgtcaaga aaaacatcat tatggtaaga tagcagaagt gaaaaaattg aagaaaatcc 1279201 gtgcgatatg cgggagaggt tctagctaca ccctctataa aaaactaagg acgagctgta 1279261 tccttggata cggccttttt tatgtttttc tagagcacct tccgaaaaaa ggtgtttttt 1279321 tgcgtgaatt agctgtagcg atgtctctcg ccggcgtttt tattgcggag aaggagagga 1279381 atcatgaaaa aagaaaaagc aattgtcgta tttagcggcg gtcaagacag cacaacatgc 1279441 ttactgtggg ccttaaaaga attcgaagaa gtcgaaacgg tgacttttca ttataatcag 1279501 cgacattcgc aggaagttga agtggcaaaa tccattgcgg aaaagcttgg tgtgaaaaat 1279561 catttgcttg atatgtcact tttaaatcag cttgcaccga atgccctgac tagaaatgat 1279621 attgagatag aagtaaaaga cggcgaactg ccatccacat tcgttccagg ccgcaatttg 1279681 gtattcttat cctttgcgtc tatcctggct taccaaattg gcgcgcgcca cattattaca 1279741 ggagtttgcg agacagactt cagtggttat cctgactgcc gtgacgaatt cgtgaaatct 1279801 tgcaatgtca cggtaaatct ggcaatggag aagccgtttg tgatccacac gcctctcatg 1279861 tggctcaata aggcggaaac gtggaagctt gcagatgagc ttggcgcgct ggattttgtg 1279921 aaaaacaaca cgctgacatg ctataacggc atcatcgcag acggctgcgg cgaatgtccg 1279981 gcatgtcacc ttcgttcaaa aggttatgaa gaatatatgg tgatgaaagg agagcgtgca 1280041 taaattgtta tctcaaattt atccgcaggc ccagcatcct tattcgtttg aactgaataa 1280101 ggacatgcat atctcagccg ctcattttat ccctcgggaa agtgcgggag cgtgcagcag 1280161 ggttcacggg catacgtata ccgtaaatat aaccgttgcc ggcgacgaac ttgacgattc 1280221 aggctttctt gtcaatttca gcgtactcaa aaaactggtg cacggaaact atgatcacac 1280281 gctattaaat gatcatgaag atttttctca ggacgaccgg tattcgctgc cgacaactga 1280341 agtcgtggcg aaaacgattt atgacaacgt acaggcttat ttagacactt tggagaataa 1280401 gccgacctgt gtacaggtgt ttgtccgtga aacaccgaca agctactgtg tctaccgtcc 1280461 gaaaaagggt ggtttgaatg gctaaaggaa ttcctgtatt agaaattttc ggcccgacga 1280521 ttcaaggaga aggcatggtg atcggacaga aaacgatgtt cgtccggaca gccggctgcg 1280581 attattcctg cagctggtgt gactccgctt tcacttggga cgggtctgct aaaaaagata 1280641 ttcgctggat gacggcggag gagatttttg cggagcttaa ggacattggg ggagatgcgt 1280701 tttctcatgt gacgatctca ggcggcaacc cggctctgtt aaaacagctg gatgctttta 1280761 ttgaactgct gaaggaaaat aacatccgtg cagcgcttga aactcaaggg accgtttatc 1280821 aggattggtt tacgctgatt gatgacctga caatttctcc aaaaccgcca agctcaaaaa 1280881 tggtaacgaa ctttcaaaag cttgaccaca ttttaacttc acttcaagag aatgatagac 1280941 agcatgctgt cagcttgaag gttgtcatct ttaatgatga agatctggaa tttgccaaaa 1281001 ctgtgcacaa gcggtatccg ggaatcccgt tttatttaca agtcggaaat gatgacgtgc 1281061 atacgacaga tgatcagtca ctgattgcac atttgcttgg aaaatatgaa gcgcttgttg 1281121 ataaggtagc tgtcgatgcg gagctgaatc tcgtcagagt gctcccgcag ctgcacaccc 1281181 tgttatgggg caacaaacgc ggagtataat agaaaggaag atgaacatga cgacaagaaa 1281241 agaatcagaa ttagaaggtg taacattgct aggcaatcaa ggtacaaatt atttgttcga 1281301 atatgcaccg gacgtgctgg aatccttccc taataaacat gtaaaccgtg attactttgt 1281361 aaaattcaat tgcccggaat tcacatcttt atgtcctaaa acaggccagc ctgactttgc 1281421 gacaatctac atcagctaca ttcctgatga aaaaatggtt gaaagcaaat cattaaagct 1281481 gtatctattc agcttcagaa accatggtga cttccacgag gactgcatga atatcatcat 1281541 gaacgacttg attgaattaa tggacccgcg ctacattgaa gtatggggca aattcacgcc 1281601 aagaggcgga atttccattg atccgtacac aaactacgga aagcctggca cgaagtatga 1281661 gaaaatggcc gaataccgta tgatgaacca tgatttgtat ccggagacaa ttgataatcg 1281721 ttaattattc cgttgtgtga tacggagtgt aaaaggaagt ggagtcacag taaaatccga 1281781 acattcagcg ttaattttca gcggaaatgt gacctggtca cagcgaagtg tgacccgcac 1281841 taagctcaat aaaagtggga aaagtcacac ctgaaaatgg ctctactcat gggaattgta 1281901 ttaaaaagtg tgacctgagg tgcaacctga actgtgactt ttatgcagtg aaaaattgat 1281961 agtacagaag cagattaagg cgtacaattt gtacgtcttt tcttttttat ccgaaagaaa 1282021 aaatgcctat ctagagatca taggcattaa atattattat caatatcttc atttattttt 1282081 tggctaagtt tctgaacctt ctctttaaca tttgaaacag ctcttttttg aatttcatca 1282141 attctcctga atatagtcga tgacacttct tattagaact tcactttcaa aattgaatat 1282201 ctcatttatt tctgactgtt cttcatctgt taggtgatgg tattgaagtt gtttagcatt 1282261 tacttcagca gctacatcaa tcctaactta gttgttctgg ttgtacaatt tcatattcac 1282321 cttctgcata ctcttgctcc gcataatagc ctccccattg acagagctcc tgcaagatag 1282381 gtttaagaga ttctccaagt tcagtggatg aatattcaac cttcggcggt acttgattat 1282441 acatctttct gctcacaagt ccactggctt caagctctct aagtgtttga atcagcattt 1282501 tctgagttat atttgggata atgcgcttta attcactcgt tctctttggt ccattcatta 1282561 aaaagtataa tacaaggcct ttccattttc cgccaataac ttcctttgtc acttcaaacc 1282621 cacagctaaa ttttttcatg tctaaagctc tccattccac atttattact ttttagttac 1282681 tatatcacaa aaaagtgggt acttccgata atgtgcttac tgaaggatac tatatcttgt 1282741 aagttgttct tcaagtactt aaaggtacta gacataaaat aaaattaatt ctaaaggagt 1282801 gttaagtatg ggtaaatttg aaggtaaaat agcgcttgta acgggtggaa caagtgggat 1282861 tggtcttgct acagcacaaa aatttgtaaa cgaaggtgca tatgtttata ttacgggacg 1282921 tagacaaaac gaacttgata aagctgttaa ccaaattggc aagaacgtaa ccggtgttca 1282981 aggtgatatt tctaagcttg aagacttaga caaactatat gacattataa agcaggaaaa 1283041 aggtaagttg gacattcttt ttgctaatgc aggcatcggc aacttccttc cattaggtga 1283101 aattactgaa gagcaggttg atagaacgtt cgacattaac gttaaaggaa ccatctttac 1283161 tgttcaaaaa gcgttatcac tattcccgga caaagtaggt tctattattg taacgggctc 1283221 tactgctgga tcaattggca acccagcgtt tagtgtatat ggagcatcta aagcagcatt 1283281 aagagcacta gttcgcaact ggattcttga cctaaaaggt actgaaatcc gtgtaaatgt 1283341 ggttagtcca ggaggtattc ttacacctgc ctacgatgag ctttttggtg atgcacttga 1283401 agaggtactg gaaaatagca gaaatactgt tccagctgga aaagttggga cacctgaaga 1283461 agtagcaaac gctgtatctt tccttgcttc agacgaaagc agttacttga cgggtgttga 1283521 attgttcgta gatggcgggc tagcacaggt ataatttcac tgcgcagaga ttacaaatag 1283581 tccccaaaaa aggttaatgg ggatttactt gaagaagtcg tataaaaaag tcgttttcct 1283641 taaaggacag ggaattcgac ttttttatat ttgaatttga ttaacgttgt aaattcgcat 1283701 tttcctgggg ctactactaa atgacctgta aaaaagatta cactgtgaat aaatgtactt 1283761 aaagtaacgg gggctcttga cttttaataa aaaataatat ccctgtcctt gtattctaat 1283821 acttttaaaa atatttaaag gaatccttat gtcctgaata accacatagg aaaatatgtt 1283881 gtaggttgct ttcttttttt gtggggcatc ccacacaagc tatctcgtga tctcacacct 1283941 gaacgttttt tatagactag taccgcgaca agttatatta catatacata ccaataaagt 1284001 agacattaaa aagtgaaaga gaggatggaa atgtgtgaaa attcttttcc ttgagagtca 1284061 tcccatgtgg ctctatggtt taccgaatgg gtttagggaa gcaggacata ccgtaatgat 1284121 ttccggtcct gtaagtcggg aaaatataac tgaaatgata gacgaattta aaccagattt 1284181 aatagtatct atgggatgga caccagagca ttcaagggaa aagcaggcct ggattcgcaa 1284241 cgctactaaa aaggtgaata tccctctcgt ttattgggca actgaagacc cgctgcacac 1284301 tcaaaacttt actatcccgt taattaaaaa gatgaaaccg gattttgttt tcacggtcac 1284361 gccttctctg tgtaaaactt atgaaagcat ggggattaaa gcagctcact tagactttgc 1284421 atttcacgaa agtatacatc accagattaa accattagcg aaatacagtt gtgatatagc 1284481 agtggtggct aatgcttacc ctaattttct tgaagaacat ccggaagtgt tccgttcgtc 1284541 ctctttaaaa acgcttattc gtcctcttat acggaagggt attcgcattg atttttgggg 1284601 gagaaactgg gaaaaaatga gtaaatatat aggaagagaa attccccgca attggatcca 1284661 tggatacctt gattatactg aagcatataa agtttacagt tcagcaaaaa tcattatcgg 1284721 tttgcaaaac tgtgaaagcc aacttacaca acgcacctat gagattcttg gttccggggg 1284781 gtttttattg acatcggata caccagcagt tcgaggtaaa ttcaaacctg gccgcgatct 1284841 catcgtttct tcctccccaa aagaaacatt ggaaaaggtt aaatactatt taaatcatga 1284901 tagcgagaga aaaaagattc agataaacgg taaaaaggct gtaaagaatg attcctatcg 1284961 gcatagagcc gagagaatgc ttgaggtgct aaaaagcaga ggaatcataa gaaacttagg 1285021 ggaaaccatt cattatgtag atgttctcaa agaaaaatac gtgatccatc atgttactcc 1285081 cggtgaaaca ttatcaataa ttgccagtaa gtataatgtt tccctgcagc aactcatgga 1285141 gcttaatcat ttcaaatcag atcaaatata tgctggacaa atcattaaga ttagagagaa 1285201 actgtttaga aatattaata acaaattatt ctaaaggaga gtaatatgaa tgaaggggaa 1285261 aatacctaaa ataagaaatc aagcgaataa agtaaaaaga acgcctcgtt atatggaatt 1285321 tcccgtgaca tacgaagtat atcatgtgga atccggcgat acattatgga cgattgccaa 1285381 atcctttgaa attccggtac aacaacttat gaatcttaat aagctttctt cagatagaat 1285441 ttatcctgga caaattataa agataagaga aagataatct ttgaggtttc ggaagcgaat 1285501 caaattgaaa tgacaatcct cattttttta tttgtgggga acttgatatt tttggggatg 1285561 aaggggttat gagatgtttc aaatgagcta ttactattct ggattaggat gggactttat 1285621 tcaacacgtt gatcaaacga acggagtatt aaatgttgtg tctcctgatt ttttctatat 1285681 cagaaaagat ggatcattac ttctccgttc agctaatccc gatgtgatta aagctcttca 1285741 tagaagaaaa ttaaaagtag ttccttttct aagcaatcat tgggatcagg atttgggacg 1285801 atttgcatta atgaaccgag ttcttttagc taaacaaatt tctcatgcaa tagaagaact 1285861 ggatttggat ggagttaata tcgatataga aaaccttaca gaaaaagatc ggaatctatt 1285921 tacagatttt attagattag taaggaaaag tattcctaga cataaagaag tatcagttgc 1285981 agtggcggca aatccttttg gctggacgaa gggctggcac ggatcatatg attacgagta 1286041 tttagctaaa tatgcagatt atcttatggt tatggcctat gatgaaagcc gccttgctgg 1286101 gcctactgca agtgtaggat gggtggaaaa gtccattcaa tatgttctga cccaaaaaat 1286161 ctctcctcaa aaactagttt taggattgcc attctatggc cgctgctgga tggaaggcca 1286221 atctgcctct caagccattc ccctttacct tgttgttagt aaaaaggcat agcgggacaa 1286281 ttatttttga caccaagagt caatctccaa aagctatttt tactgtcaat cacgataaaa 1286341 aggggccgtt gccttcggga acatatacat tatggtttga aaatgaacag tcactcagag 1286401 caaaaataaa actcgctcaa aaatataatc tgaaaggtct tggcagctgg agtcttggac 1286461 aagaagatgc gtcagtctgg aatacagtgt ttaaaaatat ataatgattt atagttcaga 1286521 acaaaattcg aagataattg caatgaatct ctaaatggac atactgaaag gagtttatta 1286581 cgagtgcggg taaaacagtg agggcattcc ataggccctt ctcccaaaat gttctacacg 1286641 aggcattaca ttgggcttga aatacacatt caaacttatg ttatagtacg cattttacgg 1286701 atgtgttgaa tttattctgc ttccatgatt taatcataca catgctactt gatagcaggg 1286761 ttatcgcatt tcattcagaa ttgttcagga tcgatatgga agcgcacgac taactagaac 1286821 tttaaaagca tacactcata tacttcctga atggatgctg gtttatctaa aaaacatgat 1286881 gagaattgat tgtacgcatg gtgaagcatg acttgttgat aatcgaccat atggtttctc 1286941 cttagaaatg agggggtttt tacataaaaa agacgagcga atccgggggg aattccactc 1287001 gccgctttct aatgaaaaga cgggatgctg gatggcagct cgtctgtttt attataattt 1287061 aacgaacgta tgtttgtaaa ggtgtctttt cgaatgaatt ggttcatata accgttaaga 1287121 acagattcat tgtaaacatt cgctaaggta tgctaagatg catggactat aaaggagtga 1287181 tatgaagtga agacattgcg gttaaacaat gtaacgttag aaatggctgc atatcaagag 1287241 gagagcgagc cgaagcgaaa aattgcattt accttaaacg ttacgagtga gacttaccat 1287301 gatatcgctg tcctgttgta tgaaaaaacg tttaatgtcg aggttccgga acgcgatctt 1287361 gccttccggg gggaaatgac aaattattca acatcattga ccaacctgta cgaaccaggg 1287421 gccgtcagcg agttctatat agaaataacg gaaatagaca aaaacgccga ttcatgatcg 1287481 gtgtttttta tgtaaaaaag ctgccggccg gcagcttttg agaaagcgaa tttcatatgt 1287541 aaggtgttaa attgtccgtc ttgcagtttt ttgaataaat gtggaaataa ggaggtttta 1287601 ataggagtct ctgatgatct tataattttt atgattaaca actgtcaatg aatctaactc 1287661 aagatcccga tagttatcca tgatcgtcac atcaacgata acagaattct catttacttt 1287721 ttcaacaaca ccggttaatc cgtttttaaa ttcaatgaca ttcccaacct tagcgatttt 1287781 cacaagcttc ctctccttta aacataataa tgccttttga aagtattttg cagtattttc 1287841 attgagaagt aaagcgataa ggagttttat ctcccttatg aattgttctg tcgctataaa 1287901 gatgatatat tgattttcgt caatagaaag aaaagggggg aatttttgtt gcgtcccgaa 1287961 gaaataacag aaatgattga acagctgcgc accggcgcca taaacgaact gagagtccag 1288021 aaagagcatt ttcttgattt cagggccgtg ttatctaaac aagatgattt taaacatttc 1288081 cgaggaattg cccagcaagg cggagatgtt atctttcaat acttagaaca gccaagaagc 1288141 tgaaggtttc tcatacgtga gaagcctttt tatcatatat gacagaacac aagcctttta 1288201 ttacagctgt ctgtaacagg tgtaaataaa atgtaaagta ccaaagatgg ataaacatgt 1288261 tttaatttaa caatatttat agaatttcag actgtttttt tgccattaag cagtgagtca 1288321 tcctctttat tccatcctga tacctccttg ggagagttgg aaaatctttt tccgtgaaaa 1288381 tgaatggatc tcttgttaag gttatgaagt gttttttgga gcactttaag gaggaaactg 1288441 tatgacaacg aaattcactg ctctggctgt ttttcttctt tgtttcatgc ctgcagccaa 1288501 aattgagcat acacaagctt cactactgag cgcaaagaag acaaaacatg aagaagcgaa 1288561 atggcttaca catatagatc gaaatacgaa tgaatctttc ccttcactgt ctgctgataa 1288621 agacaagaaa ataaaaccga ttaagctatc agcacacact gaaaagaaag agaaagataa 1288681 accggacaaa acaaatgatg agaaagaaac atatacacag tctgaaaaag agttgctgtc 1288741 ccgtctcgtt cacgcagagg ccaaaggaga atcatataaa ggcaaggtcg ctgtagcaag 1288801 cgttgtactg aacaggacgg agaaaaaagg ttttcctgat acgataagag gagttattta 1288861 tcagaaaaac gcctttgaac cggtcgcaaa cgggagcatt aaccaaaagc ctgataaaga 1288921 atcgattgaa gctgccgaag aagcgctgtc ctcaaaaaat agagaaacag atgccatatt 1288981 cttttataat ccgaaaacag cgtcagataa ttggattcgt tcaagaaaaa tcgtagaaaa 1289041 aatcggcaga cacgtttttg ccgtctaagc atagaagaga caatttgtct cagctgtgct 1289101 ttttttcata taaagagtaa aaataaaata atttttgaac ttgtctcata tgatgttggt 1289161 agtacaagag acaaggagag acatcatgaa tcgatttgtg aaagggatca ttcttttatc 1289221 cattgccgcc tttttcgctg aatgccttga atttgtcgtc aatatgattt tggcgcggga 1289281 gcttggcgag catgggatgg ggctttacat gagtattttg cccacgatct ttttaattat 1289341 tgtcatcgcg agcctggaac tgccgatatc catttctaaa ttcattgccg agtcaaatcc 1289401 taagcttcat gaaagcatgc tgaggcacgc tttcagaatg acagccattt ttactgcttt 1289461 ttctactgcc gccgctagta ttgcgcttcc gtttattccg gtatttgata cataccaccc 1289521 gtttattaaa gggattgtca tcggcttaat tcctgttgtc gcctttactt caatcgccag 1289581 gggctacttt atgggtgtgc agaaaatggg gaagatcgca attgccaatg tgctgaaaaa 1289641 aatcatccag ctcttgtgct tattcctctt ttttcaatgg tactcatttg aattggacat 1289701 ggctgtgctg atttccttgt ttgttctagt cgtgagtgat gtggtcgtgc ttgtttattt 1289761 atattcacaa tttatcatgg caaggcgggc gttatccggc cagcagcaca ttcatttgcg 1289821 cggaaaggat gtaaggaaaa gactgcttgc tgtttcaatt cctacaacag gactgcgtat 1289881 ttttcatgcg gttgtcaatg caattgaacc ctttttagta aaaggagctc ttttggctgc 1289941 gggcgttgcc gggacagcgg cgatcgatca atacggaatg ctggcaggag tggctgtgac 1290001 gatagggtcg ttccctgctt ttattgccca ttcgttaatg gtcgtcatga taccgagtat 1290061 ttcggaagct tatgcacttt ctcagtatga catcgtgtta aaaaggctga agcagtcgat 1290121 tttcattaca ttaggttacg gtatacctgc cgtctgggtc atgttccagt ttgcgggacc 1290181 tctcacgcat ttgttttttc actctcctga agcgcagtat tacttgcagc tgttgtggcc 1290241 ttactttctc tttcatctgt ttgtcatgcc gctgcaggcg tgcttaatcg ggatgggttt 1290301 tgtgaaagag gctttttatc acaatgtatg gagccatatc gttgcgctaa gtatgatgta 1290361 tgtactggga tcaatggaga atctgcaaat gctcgggatt atccttggaa tgaacactgg 1290421 catgattctt ttgacgagcc tgcactatgc cacgatctgc aaagcattga aggtatctgt 1290481 atttcttacg ggagggacca gaacgccgcg aattgaagga tgataaagga acagcagggg 1290541 caagctaatt gaaaagcatg aaaggaagat tccatgttga cgaagcgctt gcttactata 1290601 tacattatgt tattagggtt gattgcatgg tttccaggtg cggcacaagc tgaggaaaaa 1290661 cagcctgctg ttcccgctgt ttttcttatg aaaacgatag aaggggagga catctcgatt 1290721 ccgaataaag ggcaaaaaac aattctccat ttttggacgt catggtgccc gccctgcaaa 1290781 aaggagcttc cacagtttca atcgttttat gatgcccatc catccgacag tgtaaagctg 1290841 gtaacggtga atttagtgaa ttcggaacaa aatcagcaag tcgttgaaga ctttattaaa 1290901 gcaaacaagc tgacgtttcc gattgtcctt gactcaaaag gggaattgat gaaggagtat 1290961 catatcatca cgatcccaac atcatttttg ctgaatgaaa agggagaaat tgaaaaaaca 1291021 aaaattggcc cgatgacagc ggaacaactg aaggaatgga cggaagaata gctgagagca 1291081 tagactctca gcttttttca tatagagaag aagtgaataa acattaatga taattattat 1291141 caaaaagaaa ttaaaataat tataattgaa attctcttcg tgcgtgctat aataaaggaa 1291201 gacatcaaga aataactgac gataaagctg ccttttgggc agcgattttg tttttataag 1291261 agaaatgaag atgatttacg ttctcaatta gagaggagaa ttcgatatga atgaacaagt 1291321 tatcgttcaa cgcgacccgc atgagccatt gaaaacagac aagagggaaa aaaactgggc 1291381 acagcacgcg gagcttattg cagcacttgt atcaggcgct cttattttgg caggctggct 1291441 cttatccgga tatcaggtat tatccataat acttttcttg ctggcttttg tgatcggcgg 1291501 atttgctaaa gcgaaggaag gaatcgaaga aacactcgaa tccaaaacgc tgaatgtaga 1291561 acttttaatg attttcgctg ccattggttc cgccttgatc ggatactggg cagagggtgc 1291621 tattttaata tttatttttt ccttaagcgg agctttagaa acatacacga tgaataaaag 1291681 cagcagagat ttaacgtctt taatgcagct tgagcctgaa gaagcgacat tgatggtcaa 1291741 tggtgaaacc aaaagagttc cggtttcaga cttgcaggcc ggtgatatga ttgtgatcaa 1291801 acctggagaa cgcgtagcgg cagacggtat cattgaatcg ggctcgacaa gtcttgacga 1291861 gtcggcttta acaggtgaat caatgcctgt agaaaaaaac acaggcgaca ctgtattcac 1291921 aggaacggtg aatcgcaatg gctccttgac agtccgtgtc acgaaagcaa atgaagattc 1291981 gttattcaga aaaattatca aactggttga atcagcgcaa aatagtgttt cacccgcgca 1292041 ggctttcatc gaacgatttg aaaatgctta tgtgaaaggt gtgctaattg cggtggcgct 1292101 ccttttattc gtcccgcact ttgcgctggg ctggagctgg agtgaaacct tctaccgcgc 1292161 aatggtgttt atggttgtcg cgtcaccttg tgcgcttgtc gcctctatta tgccggcggc 1292221 gctgtccctg atttcaaatg gcgcccgcaa cggtatgctt gtgaaaggaa gcgtctttct 1292281 tgaacagctg ggctcagtgc aaatgatcgc ctttgataaa accggaactg taacaaaagg 1292341 ccagcctgcc gtagagacga tcagaatagc agaaggattc agtgaagcgg aagttcttga 1292401 ggctgtctat gccatcgaaa cgcaatcaag ccatccgctc gcccaagcca taacggcgta 1292461 cgctgaaagc cgcggcgtga atcagtccgg ctacatatct atagaagaaa cctcagggtt 1292521 tggcgttatg gcagaagtgt cgggtgcgaa atggaaggtc ggtaaagcag gttttatcgg 1292581 cgaggaaatg gcagcacaat ttatgaaaca aacagcatca gatgtcattc aaagcggtca 1292641 tacaattgta tttgtgaaaa aggatgatca aatagcaggc tgtatcgcac tgaaggacca 1292701 aatcaggcct gaagcaaaag aggtcatgga agaactgaac cgacttggga ttaaaacggc 1292761 catgctgaca ggagatcacg aagacacggc tcaagcgatt gccaaggaag ccggcatgac 1292821 aactgtcgtg gcagaatgcc tgcctgacca aaaagtgaat gaaatcaaac ggttaaaaga 1292881 agaattcgga acgattgcaa tggtgggtga cggaatcaat gatgcgccgg cactcaaagc 1292941 agcggatgtc ggcattgcga tgggcggcgg aacagatgta gcacttgaga ccgctgatat 1293001 ggtcctcatg aaaaacgatt tgaaaaagct cgtaaacatg tgccgcttgt ctcggaaaat 1293061 gaacaggatc atcaaacaaa atatcgtgtt ttctctagct gtaatctgcc tgctgatttg 1293121 tgcaaacttt ttgcaggcga tggaattgcc atttggcgtg attggtcatg agggcagcac 1293181 gattttagtc atactaaacg gtttaagact cctaaaataa aaccagcagc ctaatcaggc 1293241 tgctggcttt ttatgtatca agctttccct tcatttttgt ctttatcaga tcttttcata 1293301 actaggatga gagcgagggt gcagcaaagg aaacccgctg cacagcctat gatagagctg 1293361 taataataaa agcccaccat cttcatcccg ataaaaggag cggaaattcc caaaaccgtt 1293421 aagagcataa ctgcttttcg tctgaaaaaa ttcatcagca aacggaacaa cccccctgcg 1293481 attgaacgtt actgtcagta tacaggaaga ggagcaggaa ataaaatgca ttagaaaatg 1293541 aaggcgtcgt gaaaggcaaa caccggtaaa acctgttaca atggaagaca gaacaatgca 1293601 ttgcaaatgg cagggaggaa caagaagtga atagaataca acgcgtctct tcatggctga 1293661 aggaagcggg gcatactgcc gcatttattc atacgaaaga aaatgttttt tacttaaccg 1293721 gtttttacac agagccgcat gaaagattaa tggggttatt tatttttcaa gaagaggagc 1293781 ctttctttgt ttgtccagga atggaagcag gacaggcccg caacgcaggc tggaatcatg 1293841 aaatcattgg ctatgcggat cacgaaaatc cgtgggagct gatagagaag gctttgaaaa 1293901 agcgaaatat cagcatacat atgcttgcgg tagaaaagga ttcaatctcg ctgtcacgtg 1293961 cagaacagct gaagcatgcg acgggcgggg ctcaatttgt ttcagcagaa gaaacactca 1294021 atcaatttcg cctgattaaa gatgacaatg agattcgttt gctgaaagag gcggcaaagc 1294081 ttgcagatta cggtgttgaa gtcggcacag ccgctttgcg tgaaggcatc agtgaagtgg 1294141 aagtgctcgc tcaaattgag tatgagctga agaaaaaagg aattcagggc atgtctttct 1294201 ctacaatggt tttattcgga gaaaaatctg gccagcctca tggaaatcct ggtacagcca 1294261 cgttgaagaa aggtgatttt gttttatttg atctcggtgt tattcttgat ggctattgct 1294321 ctgatattac aagaacgttt gcatacaaaa ccatcaatcc gaagcaggag gccatttacg 1294381 agactgtgct tcaagcggaa aaagccgcga ttgaggcaag caaacccggt gtgagaatcg 1294441 gagatctgga tttaactgcc cgcggaatca ttgaaaaagc gggatatggt gattattttc 1294501 ctcaccggct tgggcatgga ctcggaattt cagtccatga gtatccatca atgagccagg 1294561 ccaacgatac actgctgcag gaaggcatgg tctacacgat cgaaccgggg atttatgtgc 1294621 cagagatcgg cggcgtacgc attgaggatg acgttcacgt aacaaaggac ggagcagttg 1294681 ctctgaccca atatccaaag gatttgatca tactgtaata gaaataaaaa aggactttgt 1294741 tctcgacatc gtcctttttt atctgcatta aataaaaaaa tcatcaaatg ttcgaaaggg 1294801 tttaatttca tgtttttggt tgagaggttt tacagcaaga cagctgccac cgagaacagt 1294861 gagacataac ccaattaaaa tgaagaaacc catgtgatct tctcctttca gctaaaaaca 1294921 caaaaagata tctggtacgt ccatatcata ttgtatgaaa cgcattccag atcaagggga 1294981 tttagaaaga agggaatcta tggctaatat taaagacatt gcagagaaag ccggtgtctc 1295041 tgttacaacg gtttcccgag tcataaacaa tcatccatac gtcagtgaag acaaacgaaa 1295101 aagagtgttt gaggcaatgg aatcattgga gtacacgaga aatattcacg ctgtacattt 1295161 gtcgaaagga ttttcaaaca tgattggtgt tgtcttgccg acggttaatc tgccatattt 1295221 tgcagagctg attgcaggaa tagccgacgc agccgcggaa tccggggttc acctctcttt 1295281 attccaaaca aactatgaag tacaaaaaga aatctttgcg ctgtcccaat taaagcagcg 1295341 ccaggttgac ggcctgattt tttgctcaaa ggcgcttgct gatgagaaac tcatggaatg 1295401 ggagggcccg attttgcttt gccagaattc agataatgcc cgcttcccaa ccatcagcat 1295461 tcctcaccaa gaagcatttc ggaacggctt ggactattta attgccaaag ggcacaaaaa 1295521 aatagccatc tgtttggcaa gaaaaaaagg catgaacagc cattttcgaa tcaaagccta 1295581 caaagaggca ttggaagaga tcggcgaggc atttcgtgaa gactgggtaa ttgagaaagc 1295641 gattacaatc aatgatggga aggcgctttt tcataaatgg aatacgtgga aggaaaagcc 1295701 gacggctatt tttgttgcca atgaccaagt ctcagcaggg ctttttcttg aagcaaagaa 1295761 ccagcgggtg tcagtaccgg atgagcttgc aatcttaagc gttgataacc acgaaatcag 1295821 ccaagcgctt ggaatcacaa cgatcgatat tcagacaagg gaaatgggaa agcaggcatt 1295881 tgccatattg gaaaaaagaa ttcaaggaca gccgattgaa aggaaagttc tggattaccg 1295941 tctcatcgaa agatcgactg tttagtgaat gcattgaaaa aaggtttgac gtgcattctg 1296001 ttcgttatgt acgatatgag gtattgaatg acaaaggagc tgaggatcgt gaatgggtcc 1296061 ttcacagtga aaaaggtact gaataataac gtattaattg cttctcatca taaatacagc 1296121 gaagtcgttt taatcggaaa aggtattggt ttcggaaaaa aacaagatga tgtcattgaa 1296181 gataaaggct acgataaaat gttcatttta aaagacgaga aggaacaaaa gcagtttaaa 1296241 aagctccttg actatgttga tgaaaagctc gttgatattt caaacgatgt catctatcac 1296301 ataagcaata ggacgaatca ctcattaaat gaacatattc acattgcgtt gacagaccat 1296361 atcgcatttg cgatcaaaag gcagcagcag ggatttgata tgaaaaatcc atttctaatg 1296421 gagactcagt cactatatcc tgaggagtac caaattgcca aagaagtcat agatatgatc 1296481 aatgaaaaag cgggactctg ccttccggaa ggggagattg gttttatcgc tctgcatatc 1296541 cattcagcgt tgacaaaccg tccgctgtcc gaggtcaatc agcactctca gctcatggcg 1296601 cagcttgtcg aggtgattga agactcattt caaatgaaag taaataagga aagtgtcaac 1296661 tatttgcggc tgatcaggca tatcagattt acaatagaaa gaattaaaaa agaagaaccg 1296721 actaaagaac cagaaaaatt aatgttgtta ttgaaaaatg aatatccgct atgctacaat 1296781 acagcttgga aattgattaa aatcttgcag caaacattga agaaaccagt tcatgaggcg 1296841 gaagcggttt atctgacgct tcatctgtac cgattaacca ataaaatttc ataaattcag 1296901 tttatcctta taacgtgtta ctgattcgat caggcatgag tgattgaggg aaaaaaacgg 1296961 gaagttcatt ctcgttcttt tgcgcaccca attttgctca tgcctttttg ttgtgtaaaa 1297021 gggcaaatgt aaacggttaa actggaagac ttacgcctgt gaattcgttg tcatgatttt 1297081 tagctgtaag gtcagactag taaaaagagg aggtcaattc ttatgtttaa agcattattc 1297141 ggcgttcttc aaaaaattgg gcgtgcgctt atgcttccag ttgcgatcct tccggctgcg 1297201 ggtattttgc ttgcgatcgg gaatgcgatg caaaataagg acatgattca ggtcctgcat 1297261 ttcttgagca atgacaatgt tcagcttgta gcaggtgtga tggaaagtgc tgggcagatt 1297321 gttttcgata accttccgct tcttttcgca gtaggtgtag ccatcgggct tgccaatggt 1297381 gatggagttg cagggattgc agcaattatc ggttatcttg taatgaatgt atccatgagt 1297441 gcggttcttc ttgcaaacgg aaccattcct tcggattcag ttgaaagagc caagttcttt 1297501 acggaaaacc atcctgcata tgtaaacatg cttggtatac ctaccttggc gacaggggtg 1297561 ttcggcggta ttatcgtcgg tgtgttagct gcattattgt ttaacagatt ttacacaatt 1297621 gaactgccgc aataccttgg tttctttgcg ggtaaacgtt tcgttccaat tgttacgtca 1297681 atttctgcac tgattctggg tcttattatg ttagtgatct ggcctccaat ccagcatgga 1297741 ttgaatgcct tttcaacagg attagtggaa gcgaatccaa cccttgctgc atttatcttc 1297801 ggggtgattg aacgttcgct tatcccattc ggattgcacc atattttcta ttcaccgttc 1297861 tggtatgaat tcttcagcta taagagtgca gcaggagaaa tcatccgcgg ggatcagcgt 1297921 atctttatgg cgcagattaa agacggcgta cagttaacgg caggtacgtt catgacaggt 1297981 aaatatccat ttatgatgtt cggtctgcct gctgcggcgc ttgccattta tcatgaagca 1298041 aaaccgcaaa acaaaaaact cgttgcaggt attatgggtt cagcggcctt gacatctttc 1298101 ttaacgggga tcacagagcc attggaattt tctttcttat tcgttgctcc agtcctgttt 1298161 gcgattcact gtttgtttgc gggactttca ttcatggtca tgcagctgtt gaatgttaag 1298221 attggtatga cattctccgg cggtttaatt gactacttcc tattcggtat tttaccaaac 1298281 cggacggcat ggtggcttgt catccctgtc ggcttagggt tagcggtcat ttactacttt 1298341 ggattccgat ttgccatccg caaatttaat ctgaaaacac ctggacgcga ggatgctgcg 1298401 gaagaaacag cagcacctgg gaaaacaggt gaagcaggag atcttcctta tgagattctg 1298461 caggcaatgg gtgaccagga aaacatcaaa caccttgatg cttgtatcac tcgtctgcgt 1298521 gtgactgtaa acgatcagaa aaaggttgat aaagaccgtc tgaaacagct tggcgcttcc 1298581 ggagtgctgg aagtcggcaa caacattcag gctattttcg gaccgcgttc tgacgggtta 1298641 aaaacacaaa tgcaagacat tattgcggga cgcaagccta gacctgagcc gaaaacatct 1298701 gctcaagagg aagtaggcca gcaggttgag gaagtgattg cagaaccgct gcaaaatgaa 1298761 atcggcgagg aagttttcgt ttctccgatt accggggaaa ttcacccaat tacggatgtt 1298821 cctgaccaag tcttctcagg gaaaatgatg ggtgacggtt ttgcgattct cccttctgaa 1298881 ggaattgtcg tatcaccggt tcgcggaaaa attctcaatg tgttcccgac aaaacatgcg 1298941 atcggcctgc aatccgacgg cggaagagaa attttaatcc actttggtat tgataccgtc 1299001 agcctgaagg gcgaaggatt tacgtctttc gtatcagaag gagaccgcgt tgagcctgga 1299061 caaaaacttc ttgaagttga tctggatgca gtcaaaccga atgtaccatc tctcatgaca 1299121 ccgattgtat ttacaaacct tgctgaagga gaaacagtca gcattaaagc aagcggttca 1299181 gtcaacagag aacaagaaga tattgtgaag attgaaaaat aagggtgtta gtacgccgtg 1299241 cttgtcagat gacaagtacg gttgtatgat ataatattgt gaagtaataa agctttaagt 1299301 taaaaggaga atgataaaaa tggcacaaaa aacatttaaa gtaactgcag attctggaat 1299361 ccatgctcgt cctgcgacag ttcttgtaca aactgctagc aaatacgacg ctgacgttaa 1299421 tttagaatat aacggcaaaa cagttaacct taaatctatt atgggtgtta tgtctttagg 1299481 tatcgctaaa ggcgctgaga tcacaatctc tgcttccgga gctgacgaaa acgatgctct 1299541 taacgcttta gaagaaacaa tgaaaagcga aggactcggc gagtaatgca agaattaaaa 1299601 gggattggtg cttcagccgg catcgcgatt gcaaaagcgt accggcttga agagccagat 1299661 ttaacggttg aaaagaaaaa catctctgat tctgaagcgg aagtaagccg ttttgatgaa 1299721 gcgattgcac gttcaaaaga agagctcgaa aaaatcaaag agcacgcttt gaaagaactg 1299781 ggtcaggata aagctgatat tttttctgct caccttttag ttctcagtga ccctgagctt 1299841 ctgaaccctg tgaaagaaaa aatcagcact gattcagtga acgctgaatt cgctttaaaa 1299901 gaaacgtctt ctatgttcgt tactatgttt gaatctatgg acaacgaata tatgaaagag 1299961 cgtgcggcag atatccgcga tgtaacaaaa cgcgtaaccg gccacctgct tggcgtcgaa 1300021 attccaaacc caagcatgat ctcagaagag gttattattg tagctgaaga cttaacaccg 1300081 tctgacacag ctcaattaaa ccgtgagttc gtaaaaggat tcactactga tatcggcgga 1300141 cgcacatctc actctgccat catggcacgt tctcttgaga ttccagcagt tgttggaacg 1300201 aaagctgcta caggcacgat ccaaaacggc gtgactgtta tcgttgacgg tatcaatggc 1300261 gatgtcatta ttgacccatc tgcggaaact gtaaaagagt atgaagaaaa acataatgct 1300321 tatttggctc aaaaagctga gtgggcgaag cttgtcaatg aaccgactgt ctcaaaagac 1300381 ggacatcatg tagagcttgc agcgaacatc ggtactcctg atgatgtaaa aggtgttctt 1300441 gaaaacggcg gagaagcagt tggcctttac cgtacagaat tcctttacat gggaagagat 1300501 cagctgccta cagaagatga gcagtttgat gcttacaaaa cggttcttga gcgtatggaa 1300561 ggaaaatcag tcgtcgtgcg gacacttgat atcggcggag acaaagagct tccttacctg 1300621 cagcttccta aagaaatgaa cccgttcctg ggatatagag cgattcgtct ttgccttgaa 1300681 gagcaagaaa tcttcagaac acagcttcgc gcgctgcttc gtgcaagtac atacggaaac 1300741 ttgaaaatca tgttccctat gattgcgaca gttaacgaat tcaaagaagc aaaagcgatc 1300801 cttcttgaag agaaagaaaa gctcgtaaaa gcgggacagg ctgtatctga cgatattgaa 1300861 gtcggaatga tggttgagat tccgtcaact gcagtcatcg ctgatcagtt tgctaaagag 1300921 gttgatttct tcagtatcgg aacaaacgat ttgattcaat acacaatggc agctgaccgt 1300981 atgaatgaac gtgtatctta cctgtatcag ccatacaacc cggcaatcct tcgcttaatt 1301041 acactggtaa ttgaagcagc acacaaagaa ggaaaatggg ttggcatgtg cggagaaatg 1301101 gcaggagacg agattgcgat tccgatcctt ctcggcttag gcttagatga gttctcaatg 1301161 agcgcaacgt ctatccttcc ggcaagaaca caaatcagca aattgtctaa acaagaagct 1301221 gagtcattca aagagaaaat cttatctatg agcacgacag aagaagttgt cgcgttcgta 1301281 aaagaaacat tcaagtaatg tacaaaaacc agacggcctc cggcctgtct ggtttttttc 1301341 ataagtaagg gtatagaagg acacaataac atggctagga gggatagtat gtcaaaccaa 1301401 tttaacgcag gagatactgt ttatgtgatc tacagaaatc cgcacgccgc caatgtagcc 1301461 cacataaagg aagccgaaat tgtgcaccat ccataccatg aaggcgagct ttccctgttt 1301521 atttatgaaa cctatcatcc attcgcagag gacgatgctg tgtttgcaag ctatgaagaa 1301581 gctaaatcgc tttacaaaga actgtttgat attgatccgt atgagtaaca aggaaatcat 1301641 tacaactcat atcctttccg cctagtgaga aaagtaacgt tagtaaagga aaaggatgtg 1301701 gcatcatgca gaacccattt gttccgcagc ttgtgtatat agaaccgagg gcgctggaat 1301761 atccgctggg ccaagaatta caagataaat ttgagaatat gggtattgaa atcagagaaa 1301821 cgacatccca caatcaggtg cgtaatatcc ctgggaaaaa tcatcttcag caatatcgca 1301881 atgcgaaatc aactttagtt atcggtgtcc ggaaaacatt aaagtttgat tcatccaaac 1301941 cctcggccga atatgccatt ccgtttgcaa caggctgcat ggggcattgt cattactgct 1302001 acctgcaaac aaccatggga tcaaagccgt atatcagaac ttatgtaaac gtcgaagaga 1302061 ttttagatca ggcagataag tatatgaagg agcgcgcacc agagttcaca aggttcgaag 1302121 catcatgtac gtcagacatt gtaggaattg atcatctgac acacacgctg aagcgcgcca 1302181 ttgaacattt tggccaaagt gatctcggaa agctccgatt tgtaacgaaa tttcatcatg 1302241 tcgatcacct attagacgca aagcataacg ggaaaacgag attcagattc agtattaatg 1302301 ccgactatgt gattaaaaac tttgagccgg gaacttcacc tcttgataag cggatagaag 1302361 cggcagtaaa agttgcaaaa gcaggctacc cgctaggctt tattgttgct ccgatttata 1302421 ttcatgaagg ctgggaagaa ggatacagac atctgtttga aaagctagat gctgctttgc 1302481 cgcaggacgt tagacatgac attacgtttg aattaattca acaccgtttt acaaaaccgg 1302541 ccaaacgagt gatagagaaa aattatccga agacgaagct cgaattagat gaagaaaagc 1302601 gccgttataa atggggccgt tacgggatcg gaaaatatat ttatcagaaa gatgaagagc 1302661 atgcacttcg agaggcactt gaatcctata ttgatacctt tttccctaac gcaaaaattg 1302721 aatatttcac ttaaacgggc tgttgtgatc aacagctcgc ttttttataa aaaacatttt 1302781 tccattccat caaaacgccg taattcaatg attctttatc ctccaaataa ttgctgacta 1302841 cacgaatagg tgaacgcccg caacggagga gaaaggacag cacagggtcg tttttcctgc 1302901 cttccatcac atcttcaacg tactgaacag cgctgatctc gtgtgcgtat ttataataca 1302961 aaggaatgcg gccgccgccg agaaggcgtt ccagtctttt atcaacagtc agctcataca 1303021 tcgtattcat cagccatttt ccgattccaa gctttcgata atgaggagaa acagaaatat 1303081 ccactacata taaagtattt ccatgaggtt catgattttt aatcgatccg ttgtcagttg 1303141 cttgtgccca tgtatgatca ggagaatcag gctcaaattg tacaataaga gcagtcatgg 1303201 aaccgataat tctgccattg atgagcgcgc ataaagcgcc ttccggaaag gttttgatat 1303261 ggctggcaag ctggtcctct gaccacagca attcctgggg aaacggagga gggaaacatt 1303321 cttcttgaag agaaatcagc ctctcgatgt cagtctcagt gtagtttcta atggtcagag 1303381 cctcaaattt tctgccgtca tgcacataca tttgttttag tatgatcatc actctcctta 1303441 tgttgtttca ttataacgaa gattgaattt tcagtaaata tattccgatt ttcttataat 1303501 ttattttttg attattcatt tttcaaacga aagggccgat atagaaatta ggaggggatt 1303561 ggtttgttta aaaaacttca catgaagatt gctgtttttg tttcgattat gttaatcatc 1303621 acagttgttc tcttaatgct gtcttcttat ttgacgctaa aaccgatgat tacagaggat 1303681 gggaaaaata caactcaaaa cgtgacgcag tcacttgaac aaaatattga attgcaatta 1303741 aagagttatg ccatttcgtt atcaagattg gctaatgggg aattaacgca tacatttgta 1303801 acgaaaccaa gtaaagaagc ttctcggctg tttcacgatg acattaagca aatcaaagac 1303861 aacgatgatt atgttgcgat ggcttacata ggcaccgcaa aaaaagaaat gtttacatat 1303921 ccaaaagcgg atttcgctga ggattacgat ccaacatcaa gaccatggta taagcttgca 1303981 gctgaaaccc cggatcaagt tgtttggacg gaaccttata aagatgtcgt gacaggagac 1304041 atgattgtta ctgcatcgaa agcgatctta gacaggcaaa aagtgatagg ggttgccagc 1304101 tatgacttga aactctctgc tatccagagt atggtcaata aacaaaaggt gccttacaaa 1304161 ggatttgcct ttttagctga tgcgagcggc aatcttttag cccatccgtc aaatcaagga 1304221 aaaaatatat caaaggatca aacactgcaa accatcgcat ccgagaaaaa agggatacaa 1304281 gatgtgaatg ggaaaatggt tgtgtaccaa acgattggcg agacaggctg gaaggtcgga 1304341 acgcaatttg ataccgatca attaatgtgg atttcagata aaatgaatcg ggccaatctt 1304401 tggatatcat tgattgcgct tatcataaca attattctca gctacttcct ggccaaaacg 1304461 ataaccggtc cgatacagca gctgatcgta aaaacgaaag ctgtttccgc aggcgattta 1304521 acagtgcgcg cggaatcaaa atctaaggat gaagtcggta ttttaacaag agatttcaat 1304581 ctgatggttg aaaatatgaa ggaaatggtt gagcaagtga gactctcttc agggaaagta 1304641 tctgacacct ctgaacaact aacggctgtg gctgccgaaa ctaatgaaac aagcggacaa 1304701 attgcaaaag cgattgaaga agtagccgca ggggcatcgg aacaggcttc tgaagttgaa 1304761 accattaatg aaaaatcgga aagcctgtca acgaaaatca ggcaaatcgc tgaggaggca 1304821 ggcggaatta aagaacgctc aaaatcgtcc gaggatgcaa gctataaagg acttgacgcg 1304881 ctcggccagc tgctgatgaa atcaaacgaa gccaatatgg aaacgaaaaa ggttgaaacg 1304941 atgctgctgg atttggaaaa tcaaactaag aatattgaag aagtcgttac agcgatttca 1305001 aacatatctg atcaaaccaa cttgcttgcc ttaaatgcca gtattgaggc agccagagcc 1305061 ggagaaagcg ggcgcggttt tgccgtcgta gccgatgaag tgcggaagtt agctgagcaa 1305121 tcagcccttt ctacaaagca tatcagcgag actgtgaagc ttatccagct tgagacaaaa 1305181 gaggcctctc acgcgatggt tgaggcaagc agaatgaatg atgaacaaaa cagtgcaatt 1305241 cacgaaactg gagaggtatt aaatacgata actgcagaaa tgcagtcact ggtacaaggt 1305301 attgatcaca tttacgcgga aattcaaaga atgagtgaag aacagcttgc gatttctgaa 1305361 gccattcaaa gcatttcagc catatcacag gaatcagctg ccgcagcaga ggaagtgaac 1305421 gcatcaaccg atgaacagct tgtcaccctt gataaagtca aacactcaac ggaaacacta 1305481 aaacatgcaa gccaagagct tatgaacaca attgcaaaat tcacattgta atccaattac 1305541 atccccaaac atcatttgtt ttggggattt tttattttat aagatgaata gatatggtag 1305601 tctagaaaat gaaggaaaaa tgataaattt taactaaaat ctaaacgaaa catctgggag 1305661 gaatgacctt gaaaaaaaca attggtttta tcggtcttgg agtaatggga aaaagcatgg 1305721 catcacatat tctcaatgac ggccatcctg tattggtgta cacccggaca aaagaaaaag 1305781 cagaaagcat acttcaaaaa ggcgcgatct ggaaagatac ggtcaaagat ctttcgaaag 1305841 aagcggatgt tatcatcaca atggtcggct atcccagtga tgttgaagaa gtgtatttcg 1305901 gaagcaatgg aattattgaa aacgcaaaag aaggtgcata tcttattgat atgacgacat 1305961 ctaagccttc gcttgcgaag aagattgctg aagcggccaa agaaaaagca ttgttcgctt 1306021 tagacgctcc tgtttccggt ggagacatcg gtgcacaaaa cggaacactc gcgattatgg 1306081 tcggtggaga aaaagaagct tttgaagcct gcatgccgat tttctcttta atgggagaga 1306141 atattcagta tcaaggaccg gctggaagcg gacagcatac caagatgtgc aatcagattg 1306201 caattgcagc cggtatgatc ggtgttgctg aagcgatggc ttatgcccaa aaatcaggcc 1306261 tagagccgga aaatgttctg aaaagcatca caacgggcgc agccggaagc tggtcattgt 1306321 caaatcttgc tccccgtatg ctgcaaggca actttgaacc gggattttat gtgaagcatt 1306381 ttattaagga tatgggaatt gcactagagg aagcagaatt aatgggggaa gaaatgccag 1306441 gcttgtcgct cgcaaaatct ttatatgaca agctagctgc tcaaggtgaa gaaaacagcg 1306501 gaacacagag tatatataag ctttgggtga aataaaaaaa gattgcctgt acgaaacagg 1306561 caatcttttt ttattatttt ccgatgaatt gttgtgtcca gatgcttcca gactcaacgt 1306621 aaccaacacc gatgtgagta aagttagggt ttagaatgtt ttttctgtgt ccttcactgt 1306681 tcatccaagc ttttactact tcttctggtg tcttttggcc cttcgcaatg ttttcacctg 1306741 ctgttttgta gctgattccg aaagatttca tcatatcaaa cggtgagccg tatgttgggc 1306801 tttggtgatc aaagtagttt ttgtctttca tatcctgaga ttttgcgcgt gcagatttgc 1306861 ttaacgtttc atcaatttga agcggtttta agccttgttt ttgtctttct gcatttgtaa 1306921 gttcaacaac ttttttctca tatgcactta cagatgaagg tgcagacgtt gttgtgtttg 1306981 ttttttcagc agttgcgggt gctttagaag cagtgttttg atcagcagct gctttttcag 1307041 tagtcttttg tgcaggtttt gccgtttctg tcttttgaac atcctgaact ttcacgttag 1307101 attgcttcgc atgtttttga agaagctgct tcatctcttt ttcgtttgca gcgtttaacg 1307161 ttttgatatt tgtgttaata tgcagttttt tcactgcatc gttaagtgac atgttttgta 1307221 ctgtgttccc cgtttttact gtaaccacag gctggcagga gagttctttc gctgatgctt 1307281 gctgtacgcc cccgaatgtg aataatccaa ccgcagcggc agcagataaa ataaatgctt 1307341 tcttcattag ttcgtaacct cctagagttg tttgtttcta cagaaaaatc ataacatagc 1307401 ttttttgtca taaagattcc agcactttcc tttgacaaat agagattgtc attttcgtaa 1307461 agtaaatccg ttgaatcact aagaataagg gaatcagcgg tatatatgat tttatcgtac 1307521 cgttacatag cttccttttt tttgaaccgt tagttatatt ttaatgtgtt tttatattga 1307581 cagctttttt tactcctttt cgctgtaaca actattacaa aggtgttaca attaatctca 1307641 gtatatgtaa atatattgaa tgatttgaga ggggtaacca gaagtgactg aaataggacg 1307701 tgaaccaaag aaaaagagca aaggaaacag agcaatcaga atgaaccttt ttttcctagc 1307761 tgtctttgtt ctattcactg cattaatttt taagctcggg gttgttcaaa ttgttgaagg 1307821 cgaacagcat gaagaagacg ctgagaaatc aaatgcaaaa acagcttact atcctgcgcc 1307881 tcgcgggaag atgtacgaca gaaaccagaa agttgctgtc gacaaccaga gcgttccaga 1307941 aattgtgtat gtatcaacat ctagcacaaa aacagaagat aaaatcaaaa cagcgaagcg 1308001 gcttgcttct ttcattcata ttgataccga atttttgaag gaaagggatc ttcgtgatta 1308061 ctggatcgca gctcatccga aaaaagccgc cgctctgctt aaggaatcag aaagcaatct 1308121 gaaaggagac caggcttaca agcttcaaat agagcgtgtt ccggatcaag aattaaaggc 1308181 tattcagcaa gatgacgaag aaatggaaac tgctgcgata tatacaaggt tttcaagcgg 1308241 aaatgcttac gaacctcaaa tcgtaaaggc aatgaatcca aataagagca atagcaatgg 1308301 aaaaaacgga gcgctgcttg atgagaagaa aaactcctcg caaagaccaa aaaatgactt 1308361 aacatatgat gaaatttcca ttgtttctga gcatttagaa gaacttccgg gaatcgatat 1308421 cgtaaacgat tggacacgaa aatatcctta tgacaaaacc ctttattctg ttttcggggg 1308481 cgtcacgaca cctgatcagg gcctgctgag cgaccggaaa gatttctact taacaagagg 1308541 ctatgcgaat aatgacaggg tgggaaaaag ttatttagag tatcaatatg aagaatattt 1308601 aaattcgcat aaagaaaaag tggaatacgt agaagataat aaaggaaatg tcgtcagcca 1308661 aaaaaccatt gataagggca gcaggggata cgatcttcag ctttcttttg acatggagct 1308721 tcaggcaaag gtagaaaaga tcattgaaga agaagtaaga aacagccgtg cacgcggaaa 1308781 ttacatgctt gacagagcct ttgccgtaat gatggacccg aataacggcg atattttatc 1308841 aatggcaggg aaaaagatag atttaaaaac caacaaaatt gaagattatg cgataggggc 1308901 atttaccacc caatatgaaa tgggatcagc agtaaagggg gccaccgtgc tagccggcta 1308961 tcaggacggg atcccgcatt ataaatatta tatcgatgct ccaatgcttt taggaacgaa 1309021 tcttataaaa aaatcttata ctaatatggg aaccatcaat gaattaaccg cattgcaaaa 1309081 aagttcaaac gtatatatgt tcaatgttgc catgcatatt gcaggcgtaa catacaagcc 1309141 gcatggatct ctcccggctg atcagaacga tctactgaaa atgagaaact attacagcca 1309201 gtttggtctg ggagtaaaga caggtattga tctcccgcag gaatcagccg gaatgcaaac 1309261 cacacctaaa actgtaggag gattaatttt agacttagca attggccaat acgatacata 1309321 cacaccgctt caaatggctc aatacatctc agtaatcgcc aatggtggct atcgtgttca 1309381 gcctagaatc gtcacaagta ttcataagcc aggaaaaaaa gaccagctgg gtaaggcgat 1309441 tgaacatagg aaacctaaag tactcaataa gattaataat tcagagagcg atttgaaaca 1309501 agtacaaaca ggcatgaaat tagtcacttc ttcagggaca gcaaaaaata cgtttacaga 1309561 agatgtatca gggaaaacgg gaacagcgga aacattttac tacggcacga atcgcaactg 1309621 gtgggggaaa aaaacataca atctgacttt tgtcggctat tacccgtcga aaaaaccaaa 1309681 agtggccttt agtgttgttg ttccatcagt agatgatgat gataagatca ataaaattat 1309741 tgccaaaaga gctatccacg cctacgcaga gctcgaaaaa aaacacagta aaaaataaaa 1309801 aacagggtgc acaactaaaa gattgtgtgc cctttctttt attcaaaaat tgacgttcac 1309861 cataagaata gaaggagaat actcattttc tagcgaatca tactaggtaa aagtcaatct 1309921 gtatatgtcg aaacacgatg atcatgcaaa ggagggattc tgtggaacag gatacgcagc 1309981 atgttaaacc acttcaaaca aaaaccgata ttcatgcagt cttggcctct aatggacgca 1310041 tcatttatat atctgccaac tccaaactgc atttgggcta tctccaagga gagatgatcg 1310101 gatcattcct caaaacgttt ctgcatgagg aagaccaatt tttggttgaa agctattttt 1310161 ataatgaaca tcatctgatg ccgtgcacct ttcgttttat taaaaaagat catacgattg 1310221 tgtgggtgga ggctgcggta gaaattgtta cgacaagagc tgagcggaca gaacgggaaa 1310281 tcattttgaa aatgaaggtt cttgaagaag aaacaggcca tcaatcccta aactgcgaaa 1310341 aacatgaaat cgaacctgca agcccggaat cgactacata tataacggat gattatgaac 1310401 ggttggttga aaatctcccg agtccgctat gcatcagtgt caaaggcaag atcgtctatg 1310461 taaacagcgc gatgctttca atgctgggag ccaaaagcaa ggatgctatt attggtaaat 1310521 cgtcctatga atttattgaa gaagaatatc atgatatcgt gaaaaacagg attatacgaa 1310581 tgcaaaaagg aatggaagtc ggaatgattg aacagacgtg gaaaaggctt gatggcacac 1310641 ctgttcattt agaagtgaaa gcatccccga ccgtctacaa aaaccagcag gctgagctgc 1310701 tgctgctgat cgatatctct tcaaggaaaa aattccaaac catcctgcaa aaaagccgtg 1310761 aacgatatca gctgctgatt caaaattcca ttgataccat tgcggtgatt cacaatggaa 1310821 aatgggtatt tatgaatgaa tcgggaattt ccctgtttga agcggctaca tatgaggatt 1310881 taattggcaa aaacatatac gatcagctgc atccttgcga tcacgaggat gtaaaagaga 1310941 gaatccaaaa cattgccgag caaaaaacag aatctgaaat tgtcaagcaa tcctggttca 1311001 cctttcagaa cagggtcatc tatacggaga tggtctgcat tccgacgacc ttttttggtg 1311061 aagcggccgt ccaggtcatt cttcgggaca tctcagagag aaaacaaaca gaagaattga 1311121 tgctgaaatc ggaaaaatta tcaatcgcag ggcagctcgc ggcgggaatc gcccatgaga 1311181 tccgcaaccc tcttacagcg atcaaaggat ttttacagct gatgaaaccg acaatggaag 1311241 gcaacgaaca ttactttgat attgtgtttt ctgaactcag ccgtatcgaa ttaatactca 1311301 gtgaactgct catgctggcg aaacctcagc aaaatgctgt caaagaatat ttgaacttga 1311361 aaaaattaat tggtgaggtt tcagccctgt tagaaacgca ggcgaattta aatggcattt 1311421 ttatcagaac aagttatgaa aaagacagca tttatataaa cggggatcaa aaccaattaa 1311481 agcaggtatt cattaattta atcaaaaatg cagttgaatc aatgcctgat gggggaacag 1311541 tagacattat cataaccgaa gatgagcatt ctgttcatgt tactgtcaaa gacgaagggg 1311601 aaggtatacc tgaaaaggta ctaaaccgga ttggagagcc atttttaaca acaaaagaaa 1311661 aaggtacggg gcttggatta atggtgacat ttaatatcat tgaaaaccat cagggagtta 1311721 tacatgtgga cagccatcct gaaaaaggca cagcgtttaa aatttcattt ccaaaaaaat 1311781 aaaaacaacg gcttaaacgc cgttgtttat cgtctgcatt gcttcacgtt tttttaatac 1311841 aaataattct aaacggtcta ggccttctct cagcgtgtcc attgagcatg caaaagacag 1311901 ccttacatat ccttcaccat atgttgagaa cgagctgccc ggcacgagtg ccacgccagc 1311961 gtcttccaaa agagccatac taaaatcaaa tgaagtcatt ccaaatgatt taatagaagg 1312021 gaagatataa aacgcaccgg acggtttaac tacgtcaagt cccatggaaa caagacggtc 1312081 ataaacatag tccagacgtt ttttgtattg ttctctcata atcaatgcat cgtcaaagcc 1312141 gtttgtgaca gcttcaagcg cggctttttg agaaatggat gaggcgcacg acacattgta 1312201 ttgatgaacc tttaaaatgt gctttgcaat gtctttcggt gcaaataaaa atccaattct 1312261 ccaaccggtc atgctgtgtg attttgacaa cccgttaatg acaatcgttt gatcccgcaa 1312321 ataggttgcg atggagtaat gcggtctgtc atatgttaat tcactgtata tttcatcaga 1312381 caatacgaag acatttctgc cttttaagag agctgcgatg cttttcagtt cttcttcaga 1312441 taaagtcacg ccggtagggt ttgacggata aggaagcacg acacacttgg tgttgggtgt 1312501 cagagcatct tcaatcagcc gggcggtaag cttaaagccg tgtgacgtag tatcaacaat 1312561 gacaggcttg gccccgcaca aattgataat aggttcatag cccggataaa taggccctgg 1312621 cataatgact tcatcaccgg gagataaaat cgtccggaat gcagcatcaa tggcttggct 1312681 tgcgcctgtt gtgatgataa tttcagattc agcatcatag ttgaaatccg cttttttctt 1312741 catataaagc tgcacagctt gtctcagctc caggtagccg gcattcggag tatatgacgt 1312801 cacgttttca tcaatggctt tttttgcggc agctttcaca tgatgcggtg tgaaaaaatc 1312861 aggctggccg attgtaagtg aaatgacgtc ttcgtgttgg gctacaagat tcgagaattt 1312921 gcgtattcct gaaatttcga tctctcttgc tttcggattc agcaaatgtt ccataattca 1312981 tcaccttaac aaatataatg agtttatcct attttaccac tagctgatca tttgtcacct 1313041 ttttaactga tatatttcga ttgtatgcgc cttttttcta aacatacctt tcttttcaga 1313101 aaaaaagaag acaaccagcg atttgattgt ctttattgta tcatgttcta ttattgttta 1313161 tatgtgccaa tttcattaat agccataatc aaaatgaagg tcttcgtgcc aaatcagata 1313221 cggaggatgc tcttcttgaa ggtcagctga ttctttcttc atattcaggt aagtttcttc 1313281 actgatatcc tctaaaacag tcatttcgtt ttctttaaat attactaagg tacccattat 1313341 ttacaccctt ctttggaaaa atccttgact attttatcac tgttagttgg aaagtcaatg 1313401 gttattagga aaaaagtttc ttttttgagg aacgcggctt gttgccttcg gaattcgatt 1313461 ttgaagagct gccattcact ttttacaaat tacgccgata tatacagtac aatactgaat 1313521 gcgaatagcg agggattgaa ttgtcgttac aacaatacga aattttattg gattctggta 1313581 caaatgaatt agaaattgtg aagtttggcg tgggtgaaaa tgctttcgga attaacgtca 1313641 tgaaggtaag agaaattatt cagcctgtcg aggtgacatc agtgcctcac tcccatcagc 1313701 atgtagaagg aatgattaaa ctcagaggag aaatcctccc tgtgatcagt ctcttctcat 1313761 tttttggagt agagcctgaa ggatcaaaag atgagaaata tatcgtgact gaatttaata 1313821 aacggaaaat tgtttttcat gtcggctctg tttctcaaat tcacagagta tcctgggaag 1313881 cgattgaaaa gccgacatcg ttaaatcaag gaatggagcg gcaccttacc ggtattatta 1313941 agctcgaaga cctgatgatc tttttgcctg actatgaaaa aattatttat gacattgaat 1314001 cagattcagg tgttgacacg tataatatgc ataccgaggg cttcgatgaa agaagaactg 1314061 ataaaaagct tatcattgta gaggactcac cgcttttgat gcgcctcttg caggatgaat 1314121 taaaagaagc agggtacaac aatatcgctt cgtttgaaaa tggaaaagag gcatatgaat 1314181 acattatgaa ccttgctgaa aacgaaactg atttatcaaa acagattgat atgatcatca 1314241 ctgatattga aatgccaaaa atggacggac acaggctcac aaagctgctg aaggaaaatc 1314301 cgaaaagctc agatgtgccg gttatgattt tctcatcgtt aattacggat gatctgcgtc 1314361 accgcggcga agttgtaggc gcagatgagc aaatcagcaa gcctgagatc agtgatttga 1314421 ttaaaaaagt ggatacgtat gttattgaat aaataaaaac agccgttgcc agaaagaggc 1314481 acggctgttt ttattttaaa agtaactctc gccaagtttt ttaaagaccg gtttatggta 1314541 agctggctgc tggcgatttg gcactagcgg cttttctttc atgccgacat attcttgcaa 1314601 taggtgtttc gcttttgtta aagacatttg agctttagga tttcgatacg attgattaag 1314661 tgtacctaaa tgcggaagat gttcgaagtc ttctttagtt ggaggcatgt gaaaatagta 1314721 gtctccgatt gagataagca cgtccgattg ctgttggctg aaccttggat tttttgaaaa 1314781 atgaagccct attttctttc ctttaccttc tttgacaagc ttttgcaaag cccgtttttt 1314841 cagcagatat aggtatttag ggttgggggc ggtttttgca tggcggttca cagtgtaaac 1314901 tgcttttgaa agattttcta cggttggctg cagatctttc gtatatgcat ggtcgtccat 1314961 tatttctctc ctttgctctt atcaatttct atatgtttag attatacttt tttaaagttg 1315021 aaatgcaaat attgaatgta aaaatgcgct tttttctaag aaaaaaagcg catttttaac 1315081 ctgcattata cagatcttgc cttctttttc ggctgttctt gaaatgcttc ctgaacattc 1315141 acttccacag cctgagcact gtattttggc agtgcaataa aataaaaaat aaaaacgagc 1315201 aggataataa cacccatgcc gtaataaaga taatcaatgt ttgaaacaaa cttagggaat 1315261 aacagcgcga ctaagccgag tgtcaaagat tgtgcaaaca tcataaaagg gtcctgcatg 1315321 ccgcttacac gtcccatcag ttttggatga acaatttttg gcatccaccc tccgattgca 1315381 atgttgatcg gtccgataca cattcccagt gcaaaagctg ccgcgtaata cacccataaa 1315441 atattggtgt agccgaggac gaagatcagc aaacctgcaa tgaaaatcgg tatcgacatt 1315501 aaaaagtgcg gcttcacttt tttagagatg agcgtgccga ttacgcttcc tgccagaagc 1315561 ccaaacccga gtgcgatcgt aaatacagac gtatgccact cataacggtc aggcgccaat 1315621 ccatatttca ttgtaaacat cggcaatacg gcgaatcctc cattgacaaa tccaaaaatg 1315681 aagaagccaa aaataagaga tgccagcaat ttgtttttta aaatatagag gatgccttct 1315741 ctaaagtcat ttattgaatc cttaacagaa gtctttctcc agctgaatgc accgtttggc 1315801 tgtcgggctt cttttggaat ccggcagctg cggatcagca gcccggaaat gataaagctg 1315861 acaaaatcaa gaataatggc gccttcaata ccgattgtgt tgtacataaa cgcgcctatg 1315921 ccgactccaa acaccataaa aatgctaaaa agcatctgat taagccctgc cgctttcgca 1315981 taatgctcct tcggcagaat ggcttgtacc aaactgtttt ctgccggaaa gaaaaacttt 1316041 gttacagcgc ttctgataaa taagatacaa aaaacaagag gaatattgcc ggtaaataaa 1316101 gtgaaaaaaa gcacgacagt caggcctgct ctgatccaat cacaattttc tgccaccttt 1316161 tttctatcaa accggtccgc gacgactccc acgatcagaa atacaaatat ggtcggaaga 1316221 gaatacatca gctccgccaa ggtcgtatat gaaggctggc tgctgaatcg gtccagcaaa 1316281 aaaaaagcaa aggccatgtt gcctactgtc gtgcccattt gagaagcgag tgctgcgaaa 1316341 aatagacgaa caaaattacg atttttaaat atatccataa aaacgctcct taccctaaag 1316401 gtcccacttt atcatattat aaaccgcctg tttttgaaac aaataagaaa acattaccgg 1316461 ttaatcgtga ctctcgttcc gtttggcaca attgaagcaa gttcgatcac gtctttgtta 1316521 tgcatgcgaa tgcagccttt agaaacagcc ttaccaatcg aagcgggatt attcgtccca 1316581 tgtattccgt agtgctgctt tgaaaggctc agccaataag cgccaaatgg gccgccggga 1316641 ttgcgctggc ggttaataat gtaaaactcg ccagtaggcg tttgcgttag tattttacca 1316701 acggcgatgg gataggtttt cattacccga ttatttaggg acagcgtaag ggtcttcgct 1316761 ccgattgaga ctgcgatatg atacggaatt gtataagggt ccggcagtcc ggggatgact 1316821 atggactgtc ccgcggtgag ccctgcctgc agtgacggat tagcctggag taatgcagcc 1316881 gtgctgattc tgaaatcagc cgcgatgctg ttcagtgtat caccttgctt cacctggtac 1316941 gtaagcagtt tcctcatcct ccttttttac ttataagtat tgatgaggag cccatcctgc 1317001 tacattaatt tgtgcttttt aaggtgaaga cagtgatttc aggcttggca agaaaccgca 1317061 aaggcagcct ggtcatcccg aggcctcggt ttacgtaaat atgagtgctg cccgtttgat 1317121 acattccctc tgtgtagact tttccatatg gaggcgtaat aatcggtccg taaaaaggca 1317181 gctgaatctg gccgccgtgt gtatggccgg aaagctgaag gttcacggga taatctgttg 1317241 ttttcaaggc tgcatcaggt tcatggacga gaagaatgga aaaaagtctg tcgctcagcc 1317301 ttgaaagggt gccttcataa tctgggtttc ccagcattaa gtcatcaagc gaagcaatct 1317361 cgattttgct gccatctgcg agtgacaatg tttgatagcc attgcgatat accgtgaaac 1317421 ctccggccgt catcaggctt ttgtaaacgg cagttccata gcctccgtga tcatgattgc 1317481 cgtaaataca aagcttgccg aagggagcat taagctttct caataatgga atgactgcct 1317541 ggtggtgctg gtacgtatca ggattatcaa taatatcacc tgtaaaaaca atgagatcag 1317601 gtttagattc attaattgta agaatgacag tttttaaatc ttcgagagta aagtaatcac 1317661 tcaagtgtgc atcgctgaac tgcacgattt taaaaccgtc aaatccgtgc gggatgagag 1317721 agctttttat tgtgtgttcg gttgtctcga tcatatgcgg ctcgagatac ctggcatagc 1317781 catatccccc gccggccgtt aaagccccgg cagcaagagc gccgaacatt ccttttagaa 1317841 attgtcttct ggacatcttt ttcatttcaa accaaccttt aatagagttt ttctattata 1317901 tcatctgtat ctgataaaaa tctcatatga gcatgtgctg acagaggcag ggatataatg 1317961 atagaatatt attgaatgaa taatcattca caattggagg gataaacatg gaaaaaaagg 1318021 cggtaattat taccggcggg tcaagcggca tgggaaaagc gatggcaaaa aaacaggctg 1318081 aattagggtg gcacgttatg gtgacaggga ggaaccatga ggcacttgag gaaacaaaaa 1318141 aagaaattca gacctttgag ggacaggtcg cttgttttca aatggatgtc cgttccgatt 1318201 ccgccgcttc agacatgatt aaagaagcgg taaaagcctt tggccggctt gacgcgctga 1318261 ttaacaacgc ggccggaaac tttatttgtc cggcagaaaa gctgacgccc aatggatgga 1318321 aagccgttat tgagattgtt ttaaacggca catttttttg cagccaagca gcggcaaggc 1318381 attggattga ccagaagcag cagggtgtca ttttaaatat ggcagccacg tacgcttggg 1318441 gagcgggagc gggggtcgtt cattccgctg cagccaaagc gggggtattg tcattgacaa 1318501 gaacgctggc cgttgaatgg gggagcaaat acggcattcg tacaaacgcg atagcccccg 1318561 gaccgattga acgaacaggc ggtgcggaga agctatttga atcggaaaaa gcgatggccc 1318621 gcacgatgaa cagtgtgccg ctcggccgat tgggcacacc ggaggaaatc gccgctttgg 1318681 cagcgttttt gctttctgat gaagcatcct atataaacgg ggattgtatc acaatggacg 1318741 gggggcaatg gctgaatcct tatccgtttt aatctgaata tttataagtg aatatttaag 1318801 ttattaagaa cttttatgtt cgaatgtaat acctccacaa ttaaccttct tcctatccaa 1318861 tttgataaca catagagctt tatttgttta tgaggtgttg tgtcatacgt aagccaccta 1318921 atatatgaaa ggtatatttt aaaaggggag acgaaatatg aagaacttag atttcaaata 1318981 aaacattcat ataattactt cgttaactaa aaagagaaat tataagaatg aaaggtttca 1319041 aggttacatc agattgggag gaaggtaata taatggacga gatggtatta ttaactcagg 1319101 aatggctcaa tgaaacgtac aaaggaaaaa gtggctacaa ttccattgag gaaaatggga 1319161 aaactggctg gaaaacaatg tatgcattaa ctagagcatt acaactagaa ttgggaatta 1319221 cacagacttc cgacagtttt ggtcctacaa ctttaagaaa gcttaaagaa ttaggcccga 1319281 tttctacgtc aactaattca aaaaaaaata ttgtgaaaat tattcaaggt gctctttatt 1319341 gtaaaggtta tggtccaggt ggattaacgg gtacatttgg tcagggaacg aaagaggcga 1319401 tagcagaaat gcaattgcat atggggcttt ctaaaacaga cggtgtagta acgcctaagg 1319461 tgtttaaagc tttattaaac atggactctt atatcctttt aaatggggcg tcagagaaag 1319521 ttcgttcaat acagcaatgg ctaaataata aatattacaa tagagagaat ttctacttta 1319581 tgccctgtga tggcctgtat tcaagggata ctcaaaagtc tcttgtttat gcaatacagt 1319641 acgaggaagg gttaagtgat agtatagcta atgggaattt tggaccaact actcaaagat 1319701 tgattcctgt attaagaatt ggagaaacag atgaaaaaaa cagttttatt catttatttc 1319761 aagctgctct aatctttaat ggctacaatg ttccttttga tggagtatac tctgaatctg 1319821 taagatcaaa agtaaaggct tttcagtctt ttgcaaaatt acaacagagt ggtactgccg 1319881 actttcaaac atgggcttca cttctagtaa gtactggaga ccccaatcga aaaggagttg 1319941 cttgtgactc aattactcaa attacatcgg acagggcgga gtcccttaag agggcaggtt 1320001 ataagattgt agggcggtat ctaacaaatg cgccggggag tacactaaat aaaaaaatac 1320061 aaccaggtga attagaaact atcttaaaat caggtttaaa tgtttttccg atttatcaaa 1320121 cctatggggg agcaacaaat tattttaata aagaacaagg aaagaaagat gcgtttgctg 1320181 cttataaagc agcaaaagaa tacgggttta aaaataacac tgtaatatac tttgcagtag 1320241 attatgatgc atatggtaac gatttaaaca acaatattat tccacacttc gaaggtataa 1320301 atgaaataat gaacggtttt ttaggttcaa cttacaaaat tggtatttat gcccctagga 1320361 atgtatgtac tatagtttct aaaaaaggtt tagcatttgc aagttttgta agtggtatgt 1320421 ctactggctt tagcggaaac ttaggatatc ctttgcctta caattgggcg tttgaccaaa 1320481 tttcaacaat tactgttgga aatggttctg gaatgattga aattgataat gatatttgtt 1320541 caggtttgga taatggagtt aataccataa atatagtgcc ttcagagaat aagaagtttt 1320601 ttgatcaaat tgatgtttta tatgaaactg ctgaaaaata tgctcaaatg caaagcgact 1320661 taaataatgg ggtaaaaaaa acacaattag ctaatgagtt ggttgcccag tatttaagaa 1320721 aggatgacta caaagggtgg aagtgggtcc ctaccgcagg ccagattgat cctatttatc 1320781 gtgaatgggc agtaaagcgc taggggaaga cctagtaaat ggaattgttg atcctatatc 1320841 aaaaactgtc ataggaacgc agcatcttat ggcaacttat aatgccatta tttatagtgg 1320901 tggttactct caaacactac gagattttgc tggttggact ggagatctat taacaacaat 1320961 acaggacatg aaattacacg ctcaagaatt taattcgcct tatgatgcgg ctatgaaaat 1321021 aataggtaat atgtatcaat ttagcctaga tgatttattt agtgatgtag atgcaattaa 1321081 tctagcgaat aaaacatcag ttggtgctaa tgcacaacct ctaaatatcg caattagaga 1321141 ttattatagt aataatgact gtatgaatag gttcactcaa tttgtaaata atagatttga 1321201 tggttcgtta gacaaaattt tctctgaagc agagtattat ttaaatacaa accttgaccc 1321261 agttgttgtt ccaattaggt tagcctttaa acgtgctttt gatgttgagg attatagtga 1321321 agagattgga aaaataacag cacaagcatt tagagatgtt atcgagaaaa aaatgatatc 1321381 tgaataaact gcaaaacaag cgaacgttaa aactggtcgt tcgcttgttt tattttctat 1321441 ttaaatttat gatataattt ttaaagatta aggagtgatt cattgaagaa attgttaaaa 1321501 aagttagttg tattattttt aagcagttta gttatcatct ttaatgtttg gtactttatt 1321561 atttgtgctt tttccccaga gtattatcaa aatacaaatc ttacttctaa tgaaataata 1321621 agatttgaaa aactatacca catagatttt cctgatgaaa caaaatttat taaagctaga 1321681 gagtatttgg ctgggcccgg aggagatacg tcagctgtat tatatgtgtc tctgccaacc 1321741 aagcgggtag aaaaagtttt atctgattac acgtatatga aaataaacta tactgacaat 1321801 gtcggttcaa tgtatggagt tgacgtttca aagagtgtcg ccggtttaac aactcttaca 1321861 tttggcactt acgataaaaa aggaactttc tataatatga aacatgatga tgattggatg 1321921 tataaaggca ctgactggaa tctttacttt tggacagctg ctagttataa tgctgttatt 1321981 tttgtatttg ttttggttat tgtgaaacaa atgaataaaa ttcttaatta accagtatgt 1322041 agattgataa tctcaaaaaa attttcctct tcttttaaca tactccatac gacctacttt 1322101 tccatactat gatttttttg aaatttgtgg tgtagttata attgtgcgta taatcagaca 1322161 aagatagaga agcaggtgat aacatgttgg atccacttga tattttaacg aacattgatg 1322221 atgtccttcc atattaccag gcgattttta gtgccgagga gcagaaggtt gtcggatatg 1322281 aggtgcttgg acgaattttg gcagattcag aaatccaaag tctcgggccc ttctttttag 1322341 atgcggggat acccgaagaa tataaattag aggttgataa cagaattatc cgccaggctc 1322401 ttgaccgctt tttagaggcg gattctgatc tgctgatttt tatgaatcag gatgccaatc 1322461 tgctgatgct ggatcatggt gaaagctttc tggagcttct gaaagaatat gaagcgaagg 1322521 gaatcgaact ccaccgtttt gtgcttgaaa ttacagagca caattttgaa ggggatattg 1322581 agcagctcta ccatatgctt gcatactatc gtacatacgg aattaaaatc gcagttgaca 1322641 acatcggaaa agaaagcagc aacttggaca gaatcgcgct gctctcacca gatctgttaa 1322701 aaatcgattt gcaggcgctg aaagtgtcac agccgtcacc gtcatatgag catgtgctgt 1322761 acagcatatc tttattagca agaaaaatcg gtgcggcgct gctgtatgaa gacattgagg 1322821 cgaacttcca gcttcagtac gcctggagaa acggaggccg ctattttcag ggctattact 1322881 tagtgtctcc atctgaaacg tttctagaga gagatgtatt gaaacaaaga cttaaaactg 1322941 aatttcacca atttatcaca catgagaaaa agaaactgga gaccgtctat gagcactctg 1323001 aacagtttta caaacgagtg catcaggctg tgacctcttt gagaaaaaac aatctgtctt 1323061 ctgatgatga ctttattaaa aagctggcgg aagagctgac agattgcagc ttcaggattt 1323121 acatgtgtga tgaagaaggc gatcagctga cgggaaatgt gtttaagcaa gatggagaat 1323181 ggatttatca gccggaatat gcggaaaaga actggagctg gcgcccttat tttctggaga 1323241 acattatgag aatgagaaat ctcagaaaag gttttttcag tgatctgtac agtgatttgg 1323301 aaacaggtga aatgatcaga acgttttcat atccgatgga tgatcagatg tatttattta 1323361 tagacttgcc ttattcttat ttatatgagc aggacggact gatttaacgg ctgaaaggcc 1323421 gtttttttta tgaaatgaaa aaaatatcaa aaaacgattg acattgatac tgagaatcat 1323481 tatcatttaa ttatagagag aagctactct ctgttcccca acccctctat cagatcaaga 1323541 tccgaaaaaa cttggcgcta cccccgccaa gttttttatt tgtcaaagca taggacaatc 1323601 caatgaaaca ataaacctaa ctagtggtaa acgtttaaca cggggagaaa cattgagtgc 1323661 cgaacacccc tgacactgct gcacgggtga ggaggaaaat tcgttctgaa atgattattt 1323721 cagttccgtt gtttacctct atccagcatg actcccattg attatggcca cgcgggactt 1323781 caccataaaa ttcaaaagaa ggttttgaca aagttgcaaa aaggcattct taatgctgcc 1323841 aaagattcga aaaaaattat aattatgtgc atgacattca aaaaaagcct caaactaaag 1323901 aaaaatagtt tttttcactt tttttctttg cttaaattca gcagtgaaaa tgccatcctg 1323961 tccgacttta tggtatgatg ctcaatagaa cttgtattat aataaatact tgttgatttg 1324021 aagttgcttt ttgaaaggag tcttttttta gaatgtcaca attaatgggt atcatcacac 1324081 ggctgcaaag tctgcaagaa acagcggaag cggctaacga gccaatgcag cgttatttcg 1324141 aagtgaatgg tgagaaaata tgcagtgtta aatatttcga aaaaaatcaa acgtttgaac 1324201 tgacggtttt ccaaaagggt gaaaaaccta acacatatcc gtttgataat atcgacatgg 1324261 tttccatcga aatctttgaa cttcttcagt aagattcctg aaataggggg aacaagcttc 1324321 cgcctttgca aaagtaatcg aaataaacgg taaggaacat acttgtttca tggttgtaaa 1324381 tccttgaaaa ggagtgtcgt gatggctgat tcttttctgt tttataatct ttcagaagca 1324441 cagatgacct ttcaagatgt gatggaacgg cttaaagcct ttgttcaaaa ggacccccgt 1324501 tcttcttatg tgttatcgat cggaaccgat tcacaggttt accgcgatta cacaaagttt 1324561 attaccgcat tgcatttgca tcgtacaggc aagggagctt ggggctgctt gaaaaatcat 1324621 acagtcgaca gacccataca tagccttcgg gagaagattt cgttagaaac ggcgtacagc 1324681 caagaaacgg ccgctcatat tcttgatgga cacttaatgg atattaccga tctgctcctg 1324741 ccctttaccg gtgagggggc ggatcttacc tttgaagttc acttggatat tgggaaaaaa 1324801 gggcttacaa aagatctgat ccaagaaatg actggacgta ttacctccat ggggattgag 1324861 gccaaaataa agccggattc atacactgcc ttcagctatg caaatcgttt cacaaaataa 1324921 tttggctgaa aaagccaagg taaatgtcga attatgcggt tgacgtttgt tatctgatta 1324981 cttattctag cggtagagct gaaagtaagt tgtcttgctt tcagaggtat tcagtataaa 1325041 acagggggcc tgattgcgaa tgagtcttat cggtgaacga tttacagaag aagaacaaaa 1325101 acttctgctg aatatcctga tcaaccatga gtatgccatc gagctattaa gcagtgagat 1325161 caacgatata gagacaggga ccaaaaacgt tgacggaacc acctacaaaa aacttgtaac 1325221 gctatacgac cgatttcgat ttgaaaatta atgggacacc ctataattga tactccacaa 1325281 agagtatctt ttttattgaa aggaaacttt tcgacaaata ctgataaagt ttatattatt 1325341 gcaatatagg gaatgtattg atgatgaaaa tgaaaagggg tcgaaaacat gataagctta 1325401 caatcagatc aacttcttga ggcaacagtc ggacaattta tgattgaggc ggacaaagta 1325461 gcgcacgtgc aagtcggaaa taaccttgag catgcattat tagtattgac aaaaaccgga 1325521 tacacagcca tcccggttct ggatccttcc taccgtttac atggcttaat cgggacaaat 1325581 atgatcatga acagtatttt tggacttgag cgaattgagt ttgaaaagct tgaccaaatc 1325641 actgttgagg aagtcatgct gaccgacatt ccgcgccttc atatcaatga tccgattatg 1325701 aagggattcg gcatggtcat taataacgga tttgtctgtg ttgaaaatga cgagcaggta 1325761 tttgaaggga tttttacgag aagagtcgtt ttaaaggaat tgaataagca tatacgctca 1325821 ttgaataagt aggctgtacg gtcctatttt tattatatag gcagagtgaa aaaagaaagc 1325881 gcatacataa tttaaacgag aatagggctt gaataagaaa ctaagatttt attagaatgg 1325941 gagataagaa aaacttattg ataacaaaaa ggaggacgac atgcagcttc aagagcttca 1326001 tatgctcgta gttttagctg aggaattaaa tatgagaaag gcggcagaac ggctttttgt 1326061 atctcagccg gctttatctc agcgcttaca aaccattgaa aaggcgtggg gaacaaaaat 1326121 ctttttaaga tctcaaaaag gattaacggt aacgcccgcc ggtgagaaaa tcattcagtt 1326181 tgcgaatgat gtgacattag agcaggaaag aataagagaa aatattgacg agcttgaagg 1326241 tgaaattcac ggcacattga agcttgccgt cgcctccata atcggtcagc attggctccc 1326301 taaagtcctg aagacgtatg tggaaaagta tccgaatgca aagatctcgc tcataaccgg 1326361 gtggagcagc gaaatgctga aaagcttgta tgaggatcag gttcatatcg gcattataag 1326421 aggcaaccct gagtggaagg ggcgcaaaga ttacttaatg acagatcatc tgtatttagt 1326481 ggatactgaa atttcctgca tcgaagatat tgcccataca gaacgtccgt ttatccagtt 1326541 taaaagtgac agcacttatt ttcaggaaat tcagcactgg tggcatcaaa aatttaaaac 1326601 gtcgccgaaa cagacgatat tggttgatca gattgaaacg tgcaaacaga tggcgctgca 1326661 cggaatcggt tatgccattt tgccgtctgt tacccttcaa aatgaagata aagtgaataa 1326721 aatgcctctt ttagacatga aagggcatcc gatcggtcgg gatacatggt tattaggtta 1326781 tgagcctgcc tttgaactga aacaagttca agcttttgta caagtgataa aggatatgct 1326841 ggatcaggaa aatccatttt aaagacagcg aggtgctgtc ttttttttat ttatctgttg 1326901 acaatgaaaa tcattatcat ttaaagtgat acatatgata ttgaaaatca ttatcaacta 1326961 atggggtgat aacatggcta aagccttgat tacatatgcc agcatgtcag gaaatacaga 1327021 agacattgcc ttcataataa aagatacgct tcaggaatat gagttggata tcgattgtgt 1327081 cgagataaat gatatggatg cgtcttgttt aacctcctat gattatgtac tgattggcac 1327141 ctatacatgg ggggacggcg atttgcccta cgaagcggag gattttttcg aagaggtcaa 1327201 acagattcag cttaatggtt taaaaacagc ctgcttcggg tctggcgatt attcttatcc 1327261 aaagttttgc gaagcggtga atttgttcaa tgtcatgctg caagaggcgg gagctgctgt 1327321 ttaccaggaa acactaaaaa ttgaattagc gcctgaaaca gatgaagatg tggaaagctg 1327381 ccgagcgttt gcgagaggtt ttcttgcatg ggcagattat atgaacaagg aaaaaatcca 1327441 tgtttcataa aggggcaacc gctgttacgg catcggcgtt ttctggatat tttgtggcgg 1327501 tacaaagaga aggcattttt cattactctt tggagcaggg ctggagaaag ctttttcgtt 1327561 tgaaaagtaa gatacactgt atcagctaca tagggcctta cttatttggc gttggtgaaa 1327621 agggaacagt cattcgttcg gctgatgaag ggaaaacctg gacgatgtcg agctttccga 1327681 caaatgcaac agtgtgggcg attaccggca gaaacaacgg gtttgtctgc gcccacggta 1327741 agcattgtat ttatgtatcg gatgattttg gtgtctcatg gcgcgtagcc aaaccttttg 1327801 ccgaatttca taatccccct gttatccggt cgttatgcct tcacgggggc aatctcttta 1327861 tcggcacgca aatacacgaa tattttggcg gcatttgggc ttacgacatt aagcgtgaca 1327921 ctgtccaagt tgtcaaaaaa gaaaaaaacc ggatgacggc atccatgctc gtgttcaatg 1327981 aaaattggct ggtggcggcg atgggttctg tgaaaggaaa gcacggtgct gtcactgtaa 1328041 ggaatctttt gaatggtgaa gaattcacca tacaatccag tatgatcaga aatgaagaat 1328101 catttcttga tctttcagag gatgatggca ttatatatgt cactacaaca caagatgaaa 1328161 atggtttttc gagaatttac caggttgatc tcgaagcccg gtcgttaaaa tggttcgata 1328221 ccattaaggg acatggatgg agagtggcca atcagaaaga gaatttcttt tgcgcaggct 1328281 tgtatgaatg taaatttgtc cagccgtacg aagtttcagc aatgattcat tagaggagga 1328341 acaaggaatt ggcgaagatt ttgctcgttt atgcaacaat gtcaggcaac actgaagcta 1328401 tggcagattt gattgaaaag gggcttcagg aggcgttagc agaagtagac cgtttcgaag 1328461 caatggatat tgatgatgcc cagctgttta ccgattatga ccatgtcata atgggaacct 1328521 acacgtgggg agacggagat ctgcctgatg aatttttaga tcttgttgaa gacatggagg 1328581 agattgattt ttccggcaaa acatgcgctg tattcggttc cggtgataca gcatatgaat 1328641 ttttctgcgg agcggttgat acgctagagg caaaaataaa agaacgcggt ggagacattg 1328701 tgctgccttc ggtaaaaatc gaaaataatc cagaaggtga agaagaggaa gaattaataa 1328761 acttcgggag acaattcgca aagaaaagcg ggtgcgctgt ctgatcactc actgggaact 1328821 gctaaaacgg ctgttccttt ttttcttgtc tttgtatctt tcctttgata cagtaatgag 1328881 gtagaaaatc aggaggagga ctatacatat gaaaatgatg gacgcaaatg aaattatttc 1328941 atttattcaa aatagtacaa aatctacacc tgtaaaggtt tacgtgaaag gtgagctgga 1329001 aggaatcaat ttcggtgaat ctgcgaaagc ttttatcaat ggaaacactg gtgtcgtttt 1329061 cggtgaatgg agcgaaatcc aaacagcaat cgaagaaaac caaagcaaaa tcgaagacta 1329121 tgtggttgaa aatgaccgcc gcaattctgc gatcccaatg cttgatctta aaaacatcaa 1329181 agcgcgtatc gagccgggtg cgatcatccg cgaccaagtt gaaatcggtg ataacgcagt 1329241 catcatgatg ggtgcttcta ttaatatcgg ttcagtcatc ggcgaaggca caatgattga 1329301 tatgaacgtt gtgcttggcg gacgagctac tgttggaaaa aactgccata tcggcgcggg 1329361 ttctgtactt gcgggcgtta ttgagccgcc atccgctaaa ccggttgtga ttgaagacga 1329421 cgtcgtaatc ggcgcaaatg ctgttgtgct tgaaggtgta acagtaggta aaggagctgt 1329481 tgttgctgcg ggagcgatcg tggtaaacga cgttgagcca tacactgtcg ttgcaggcac 1329541 accagctaaa aaaatcaaag acattgatga aaaaacaaaa ggcaaaactg aaatcaagca 1329601 ggaattacgc cagctgtaag gaaaagtttg ataaaaaagg cgtggataat atatccacgc 1329661 cttattcgta taggcaggag gaatagaaat gaagatagag gagctcatcg caattcgcag 1329721 agatctgcat cgtataccgg agcttggatt tcaggagttc aaaacccagc agtatttatt 1329781 aaatgtcttg gaacaatatc cgcaagacag aattgaaatt gagaaatggc gaacagggct 1329841 ttttgtaaaa gtgaacggga cggcgccgga aaaaatgctg gcatacagag cggatatcga 1329901 tgcgctttct atagaagagc aaactggtct tccattcgca tcagagcatc acggcaacat 1329961 gcacgcctgc ggtcacgatt tgcatatgac aattgcactc ggcattattg atcattttgt 1330021 tcaccaccca gtcaaacatg atttgctttt tctgtttcag ccggcagagg aagggcctgg 1330081 cggtgcggaa ccaatgcttg agagcgatgt attaaaaaaa tggcagcctg atttcatcac 1330141 tgcccttcat attgctccag agcttccggt aggcaccatt gcgacaaaaa gcggccttct 1330201 atttgcgaat acatcagagc tagtcatcga tctggaaggc aaagggggac atgcggcata 1330261 tccgcatttg gctgaggata tggttgtagc agcaagtaca cttgtcaccc agctgcaaac 1330321 gattatctct agaaacacag atccgctaga cagtgctgtt attacagttg gtaccattac 1330381 cggaggctcg gcacaaaata tcattgcaga aacggcccac ctggaaggca cgatccgcac 1330441 gctttctgaa gaatcgatga aacaagtaaa ggaacggatt gaagatgtag tgaaaggaat 1330501 cgaaatcgga ttccgctgca aaggaaaagt gacatatccg tctgtatatc accaagttta 1330561 caatacgagc ggattaacag aagaatttat gtcttttgtt gctgaacatc aactggcgac 1330621 agtaattgaa gcaaaagaag caatgactgg agaggatttt ggctatatgc tgaaaaaata 1330681 tcccggattc atgttctggc tcggcgctga ttctgaacat gggcttcatc atgctaagct 1330741 gaatcccgat gaaaatgcga tagaaacagc ggttcatgtc atgacaggtt atttttctgt 1330801 ttatgccaat taagtacaaa tgaaagaata aaattccata aaatgagcac tctagtaaac 1330861 ggaggtgttc aaaaatggct aaaaaaattg gaattgaaca atcgttatca gatgtagaag 1330921 ctgctttaaa agaaaaagga tatgacgttg taatgatgaa aagccctgct gatgctcaag 1330981 gctgtgactg ctgtgtcgta acaggtcttg ataataatgt gcaagggata gccgatacgg 1331041 taacacaagc acctgtcatt acagcttccg ggatgacggc tgaagaaatt tgtagcgaag 1331101 ttgagagcag aattcagtaa taaaaaaacc gaagcaaaaa gcttcggttc ttttatttat 1331161 tctgtttctt tagggaaagc gcggtcgaac gcgttcttta tttcttttct caacactcgt 1331221 tcgactcgcc actgttccat attttctgtt ttggcaatga ccctgattac aatttcagaa 1331281 gtccccagtt cttgaatccc gatgacattt gggccttctt ttatttgtgg aagagccgct 1331341 gccgtttcat cacaaacctg ctgtaaaata tgaatcattt catcaatatt tctttcagcc 1331401 ggcactttaa tgtcaacaag agcctgcatg gtaccacgag aatgattgct cacgtttgtg 1331461 atgtttctgt tggggatgta atgcagtgtt ccgtcaaagc tgcggatttg agttgtcctt 1331521 aagccaacct gctcgacaat tccgtcaaag gtggaaacgg taatataatc tccgacatcc 1331581 aattgtttct caagcaaaat aaaaaaacct gtcacgatat cactgacaag cccttgggcg 1331641 ccaaatccga cagccaggcc gacgattcct gcccccgcta aaagagcgct tggatcataa 1331701 tgaaacaaat ctagaaccat gacgaaaaat atgaaaatca atgtataagc aaatatgtta 1331761 agagtcaggc ttcggagcgt atgtgcacgt ccgatagaca agctattctg ctcctcgaat 1331821 tttgcaaaca gatgtttaat gattttcatg cctaatgatc gaacgataaa atagagcaat 1331881 atcataatgg cgagtttaat gagcagaaca ccggcatttg taatcagtcc cgcccaatca 1331941 tattgtttaa taaagtccat gttgagctcc ttttctaatt gattgctgca cattgagact 1332001 agttaccctg tacatgacca tgttaaacgt tttattcaaa aatgtcgaag ccaaagacat 1332061 acatgatttg ttaaaaattg actcaggaaa tctgctttta tataatggca ttgcaatata 1332121 actaaaaatg gttaatcacc ctttattttc atgcgatttt gacctttaag ccaaacaata 1332181 aattggaggg atacatatgg cagaacgtat ggtaggtaaa caagctcctc gttttgaaat 1332241 ggaagcagtc cttgcaagca aagaattcgg caaagtaagt cttgaggaaa acatgaaaaa 1332301 cgacaaatgg acagtgctgt tcttctatcc aatggacttc acttttgttt gtccgacaga 1332361 aattacagca atgtctgacc gctatgacga gttcgaagat cttgatgcag aagtcatcgg 1332421 ggtttcaact gataccatcc atactcattt agcttggatc aatacagacc gcaaagaaaa 1332481 cggtcttggc cagctgaaat acccgcttgc tgctgataca aaccatgagg tatcccggga 1332541 atatggcgtt ttaatcgaag aagaaggtgt ggctttgcgc ggattgttta ttattaatcc 1332601 tgaaggggag cttcaatatc aaactgtttt ccataacaac attgggcgtg atgttgatga 1332661 aacgcttcgt gttctccagg cgctgcaaac tggcggactc tgtccggcta actggaaacc 1332721 aggccaaaaa acactttaat tctttccaag aacgaaaagc ggtctagcat attcgttagg 1332781 cctctctttt aaaataggag ggaaaaagca atgaaattac gtcagcccat gccggaattg 1332841 acgggagaaa aagcttggtt aaatggtgaa gtgacgagag agcaattgat tggggaaaag 1332901 ccgacgctta ttcatttctg gtccatcagc tgccacttgt gcaaagaagc gatgccgcaa 1332961 gtgaatgaat ttcgtgataa atatcaagat cagctgaatg ttgtagctgt acacatgccc 1333021 cgttccgaag atgatcttga ccctggtaaa attaaagaaa cagctgctga acacgatatc 1333081 actcagccga tttttgttga cagtgaccat gctttaaccg atgcatttga aaatgaatat 1333141 gtacctgcat attatgtgtt tgataaaaca ggacagctcc gtcacttcca agccggcggg 1333201 agcggtatga aaatgcttga aaaacgtgtg aaccgcgttc tggctgaaac ggaataggta 1333261 tctgactaaa tagtatttcc taaaaacctg acctcatcag gttttttatt tgtgcaaaaa 1333321 gcaatggaag aagagtaaga agcttatttt tccaaatttg ggtataggaa ttgatgattt 1333381 gtttgattga tacgctaaaa aacacagcta atttttgatg tttttcctca attttagata 1333441 aatctcatat ctcataactc gaaaattgta gatattacac taaatttctt taaagaagta 1333501 agtaaaatat atattttcaa cattatacca aataaactag aaagcccctt aatcccttga 1333561 gaataaagga ctcttttgaa aaataaaaca ttttcagaaa ataaggaatt tttcatagag 1333621 taaatataat agtaaaatgc taaaataata gttgataaaa ttacttttgt aatctaatat 1333681 cttaattaaa gatgttaatt ttgatagggg gtacattgag gaatgtttaa tgaaagagaa 1333741 gctttgcgct tgcggttaga acaattaaat gaagctgaag tgaaagtcat tcgtgaatat 1333801 caaattgaac gtgataaaat atacgcaaaa ttaagagagc tggacagaaa tggaagccct 1333861 tccgaaatca aaaaggattt ccgttctgaa aaaaaacctg actctctgcc ggttctcgct 1333921 gagcttgcgg ctcaggaaat cagaagctat cagccgcaat cacagcagca gtctgttcag 1333981 cctcagcttc aatctatttc ctctcttcct gccggtatac cagacggaac aacacgaaga 1334041 agaagaggaa cggcaagacc gggatcaaaa gcagctaagc tgcgtgaagc tgctattaaa 1334101 acattaaaac gccacaacgc ggcgattaag agctcggagc ttcaaaaaga gattgaaaaa 1334161 gaaagcggtc ttgaaatccc taatatgaca acgtttatgc aaagcttaat taaaatgtac 1334221 ccggaagtga aaaagccata tcgcgggcag tacattttag agggtgaaat cgaatctgca 1334281 gaatcagcaa acgaataaat ataaagaaaa actgcttggc atcgctcaag cagttttttt 1334341 attgaggttt tttctgtgaa ggtttgtttt ctttttcaag attaagctta tacacccact 1334401 tttgataagg cttttcttca gcggctctgt ttttcagctc ttcgattgta tggctcttgg 1334461 cctggtctga tgattgggcg tgggcaagct gtttttgaag cacatgtatc tgtttggtga 1334521 catcttcaag gatagtctct acatgatttg gctgcgcgta ggccgctgga gcttcttctt 1334581 ccgttttttc tttttgtttc gtgccgccat caatatcggc aaaatgagaa gcaatccagg 1334641 catcgctttc atcaagttgc cgtttatacg atataatagt ttcgtgaaat aatttttctt 1334701 tcgttttttc tatgtctagc agtctttctt tcgtttctat gattcgatct ttcatatgat 1334761 caacttctat tttaatatgt tttagctgat attctttttc taccatttgc tcttttagac 1334821 gcccgttttc ggcttttatc aattcggctt gctgttttgc ctgaagcagt gcattttgtt 1334881 cctgctcaat tgaggcttga agttcgctga tccgtttatg aagattttta ttttcttctt 1334941 cgattttgac tttcgcaata tgaagtttat gtttttcttc gatttcggct ctgcgtttat 1335001 aggtttcagc agatagaagc tcctgcaaaa caacgatttt atcaagcagt tcagctctta 1335061 tttggtgcag ggtttggctg gtgtgggagg catgtttttc ttttgttgac atatgtgtta 1335121 attcggcaga cagctgctgg agtttttctt tcatatcggt attttctttg agcagtttgt 1335181 tatttttctg atgaaagtag cttgcttcaa gttcagaaat cagcttatgg caccttgaaa 1335241 gctcggattt taaataaagg ttctcctgag acacgtcgtg gaaaaaagga cctgatcttt 1335301 tcattcgaac catctccctc atgatgttaa cactacaata tgcaaatact gaacagctat 1335361 tcctctttaa taaacagaca agcagtagcg ttgagccttt gcttttgcta tgcttttaac 1335421 gaaactagag gtgagatgat atgaagcatg taaacgtact gctggcaggg ggagcctcac 1335481 gtcgctttgg agaaccgaag gcgtttgtca aatggaaggg caggatgctt tacgaatgcg 1335541 ctaaagaggc acttggagaa caaacggtta tcatcagccg tcccgaattt attgatagat 1335601 ttcaagaaaa cggtgaaaat gaagtgtatc aagatgctga gccatttcaa ggcatggggc 1335661 cattggctgg tatatatacc gcttttaaaa agacagacgg tgatctttat actgttcttt 1335721 cctgtgacac accgctgata caaagaagga cgatgctgga gctcaaacgt ctgatgattg 1335781 ccggtgcgga cgcggtagtc ccaatttcag acggacaagt gcagccattg attgcgattt 1335841 accacaaacg tatcatgcca gttctatacg atcagctttc tgagaagagg ttgagaatat 1335901 cagatttatt aggcagaatt tcggtttgtt acgtacaggc tgaaaatatc ggagcaaacc 1335961 cggcagagtt tatcaacatt aatacacgtg atgattttag ctgtttggaa gaaaaatcga 1336021 actccctcaa gcgggactga cggggcaata acatgataag atgacataaa agataaggag 1336081 aacaggtttg atggaggaac gttattcacg gcaaatcaga tttaagcaaa ttggggaaga 1336141 gggccagaaa agactggcag acagccatgt gctgattgtc ggagcgggag cgctcggcac 1336201 tgcaggagct gaagggcttt cgagagcggg agtcggtacg attaccatta ttgaccgtga 1336261 ctatgtggag tggagcaatc ttcaaaggca gcagctttat acagaaagcg atgccaaact 1336321 ccgcatgccg aaagccatgg ctgccaaaga gcatctatca gcgattaaca gcgagataca 1336381 tattgaggcg tatgttaccg aaggaacagc cgaaacgctt gagccgctga ttgaaaaagc 1336441 agatgtcgtg atcgacgcga cagataattt tgaaacccgc atgctgataa acgatcttgc 1336501 ccagaaaaca aagacacctt gggtctatgg cgcctgtgta agcagccagg gaatgttcat 1336561 gactgtcatt cccggagaaa ccccttgtct gtcttgtttg tttgagcaaa ttcctgtcgg 1336621 cggggcgacg tgtgatactg ccggcattat tccgcctgct gtgcatatcg tttcagcata 1336681 tcagcaggct gaggcattaa agctgttaac cggccaaaaa gaagcaatac agcgggggtt 1336741 tgtgacattt gatgtctgga acaattcgca tatgaagatt aacgttaatc atgtacgccg 1336801 tgaggaatgc ccatcttgcg gagctaatgc ggtatatcct tatcttcagg attggaacac 1336861 accaaaagct gctgtactat gcggccgtga tacagtgcag gtaaggtcag aatcattaaa 1336921 aagaatcccg aaacaggagc tcattaagcg gctgaaaaca atcggcaagg tcgaggctaa 1336981 tgcgtttttg ctgcatattt tttacgagga tttcagaatt gtcattttca atgacggacg 1337041 ggcactggtg catggaacaa atgatgtgaa agaagccaac tccgtgttgg caagagtgat 1337101 tggactgtaa caacaggagg ggtcagaatg ctggagaaaa gaacaccgat accggtagac 1337161 gaggcagttc ggcgtgtctg ccattttcaa aaacaaggtg aaacagaatg ggtggcgctt 1337221 gaagacagcc ttcatcggtt tttagccgaa gatataactg cggatcacca cgtacctgcg 1337281 tttgaccgtt cgccatacga tggttttgct gtcagagcgt gcgatacggc agaagcttca 1337341 cgtgaaaacc cagttcggtt tgaagttatt gaccatattg gagcgggagc agtatctgaa 1337401 aaagaacttg gcccgtttca ggccgtgcgg attatgactg gcgcgcaaat ccctgaaggg 1337461 gcagatgcag tcgtcatgat tgaactgact caagcctttg aggagaatgg gaagtcattt 1337521 atgtctttaa aacgccgctt tcagacgggg gataatattt caaaaacagg tgaggacgct 1337581 caaaaaggga gtgttttact gacaaagggc acccgggtga caccaggagt gacggctctt 1337641 ttggcaacat tcggatacgc atctgtgcct gtcgtgagaa agcctgtagt cgggattatc 1337701 gcaaccggta ccgaattgct gaatgtcagt gatccgctgg aaccgggaaa aatccgcaac 1337761 agcaatgcga gtatggtata tgcgcaagcg atagaagcag gcgcaacacc gctttattta 1337821 gggaaaatct ctgatgaact ggataaaagc tttgctgcag ttaaagaagc gatgaaaaag 1337881 gtggacttcc tgatcacaac tggcggtgtg tcagtcggtg actttgactt tttgcctgcg 1337941 atctatgaaa aactcggagc ggacgtgctg tttaataaag ttgccatgcg cccgggcagc 1338001 gtgacaacgg tggcgcatgc aaacgatatg ctgctgtttg gcctttcagg taatccgtcg 1338061 gcatgctatg tcggttttga actgtttgtc aaaccgataa tccagacatg gctgctcaat 1338121 gaaacaccgc attcaatttg tgcggaagct gttttgacca aggattttcc gaagccgaac 1338181 ccatttaccc gatttgttcg tgcgctcgtg caccatcagg aagggaagct gttggcgaca 1338241 cccgttggct tagataagtc gagctctgtc acatcacttg cagatgccaa tgcatttatt 1338301 atcctgccgg gcggtacgcg aggctacgaa tctggcagaa cggttcaagt gctgctcatc 1338361 agagaagaga atggaagtga atggccttgg tccgtccttt cccgatcgtc caagttgtag 1338421 gatttcaaaa cagcgggaaa acaacgttta ttgagcgcat tcttgaaaaa gcctctgaac 1338481 agggagtcca tttgggctgc ctgaagcacc atggtcacgg cggtgaaccg caaacgctca 1338541 cggaaggaaa agacacggac cgttacaagg cggcaggtgc tgatgtaaca gcggtagaag 1338601 gtgctggtgt gttacagctg actgcccgcc gcaattggga tttggcacgg ctgattgagt 1338661 tataccaatt tctcgaaaca gactgtcttc tgattgaagg ctttaaaaaa gccccttatc 1338721 ctaaagtggt tatcctaagt gaaaaggaag atctggaagc gctgcaagca gtaaatataa 1338781 tcgccatcat ctatagaaaa aaagagcata tgacagagca tcagggatta cccgtttttc 1338841 atgcggatga tccggttgcc gtggattttg tgctttcaca gctgaagggg gaatctgcat 1338901 aatggaacgg tttgagatta cgaaaacacc cattaatact gaaaacatca tcaaaaaagt 1338961 ggagaaacgg gaagcgggag ccattacaac atttattggt acggttcggg aatggacaaa 1339021 cggaaaaaga acggttcggc ttgaatatga ggcatatgaa ccgatggccg tgcaaatgct 1339081 tgctcaaatc ggcgctgaaa tcgaagaaaa atgggaaggt gcctcagctg cgatcacgca 1339141 ccgtataggt gtgctcgata tcggtgaagc agcggtagtg attgctgtat cttctcccca 1339201 tcgaaaagcc gcatatgaag ccaatgagta tgcgattgaa cgcattaaac agattgtgcc 1339261 gatttggaaa aaagaaattt gggaagacgg tgagcaatgg atcggcgacc agctagaaac 1339321 gacagcttat ccgaacggaa aaccagacct aagcgaggga gagcagcatg attaaaattc 1339381 ttttatttgc agggcttgct gaacaggccg gtacacaagc aatagaaata gatatggaac 1339441 aagcaaccac agatgaaata aaagcgagtc taaaagaaca atacggtctt gaatctattg 1339501 atacggctat gattgccgtt aacgaaagct atgtaaaaga aaatacctct gtatcttcgg 1339561 gtgacacggt agccatcata ccgccggtca gcgggggatg aaaaccggac ggcatttcag 1339621 ccgtccggtt tttctgtatt tcattggcat atccccaagt atcctcagca tacaatgatt 1339681 ttctgtaagc gtttattcta catatgttac tccctataaa gtaagagact cactccataa 1339741 ttagactgaa attttgaaaa ataatagaaa tttatttcgg gtatcgatat agtgaagatg 1339801 ataaatgttg gaaaggtgct ggatatggag acatttaaaa gattaaaaat gtattattgg 1339861 ccgtacagaa aagtgtttat gtggtcgctt ctagccatgc ttttgatgac tgcaattact 1339921 gtcgtttatc cgattatcct gcaaattacg attgatgaga tcgtactggg acggcagtat 1339981 cagcttgcgg cgtgggtcag cttaggattt attgcggtga tggttttgaa aggaatggct 1340041 accttttttc atcagtattt aggtgatatg ttcgggatca aatccgttta tcggctgaga 1340101 aatggtctgt atgaaaaact gcagcggctt tctttttctt actatgataa cgcgaaaaca 1340161 ggagatttga tgtccaggct gactgctgat gttgaagggc ttcgtttttt cttatcatac 1340221 ggtctcgctg agctcattcg cttcggcctg ctggtagcca tcagcctgtc ggttatgttt 1340281 tactattctg ttcctctcac gcttgtgaca atagctgttc tgccatttct cgcggttgcg 1340341 gtataccggt ttgacaaaag agtccatccc gccttcagag gcatccgcaa atcgtttgcg 1340401 aaactcaata caaaagttca ggaaaatatc agcggcatta atacggttaa atctctttcc 1340461 agggaagatt ttcagatcag cactttcaat aaagccaatg cagaatacag ggcgcagtat 1340521 ttacaaacat catccatttg gtctgcgtat ttccctttaa tggagttcat tggtaacact 1340581 tgtattgtag ctcttctctc atacggcggt tacttggtta tgcaaaatca gctcaatccc 1340641 ggcgagcttg ttgctttctt cagccttgtc aattatatga tgtggcccat tatgaactta 1340701 ggttttgtca tcaatatgtt ctctcaagca aaagcgtcag gggaacgcct gctcgacatt 1340761 ctggaaaaag aagaagacat tacagatcat cctcatgctt tgcataaaca aaaattaacc 1340821 ggagatgtcc atttcaaaaa tgtttctctt gcatacggaa aagaacaaac aaacgcgctg 1340881 tgcaatgtaa gctttgaggc aaacagcggg aaggtaatcg gactgttggg cccgacaggt 1340941 tcaggcaaaa gctcagtgac acagcttctc accagatttt acagtcctgt tggcggaatg 1341001 attaccattg atcacaaacc catcacagat tattcgttaa aaacccttcg ctccaatatc 1341061 ggggtcgtac ttcaagaatc cttcctgttt tcatctacga ttagatcaaa tatttcgtat 1341121 gggcggccgg atgcctcaat ggaagacgtc atcgaagcgg caaaaagggc gcaggctcat 1341181 aactttatta tggagcttcc tgatgggtat gacaccatgc tgggagagag gggaatgggg 1341241 ctttccggcg ggcagaaaca gcgtattgcc attgcgagag ccatctgctt gaacccgagc 1341301 attttaatat tggatgatgc cacaagcgca gtagatatgc aaacggagca cagcatacag 1341361 cttgccttaa aagaagtcat gaaaaaccgc acaaccttta tcgtcgctca ccgcatttct 1341421 tcactgaaac acgctgatga aattctcgtt tttaataaag gacgcattcg tgaaagggga 1341481 acacatcatg agcttcttga aaaaggcggc tactataaaa agatttacga tttgcaatac 1341541 cgtgatgtca aaatgattaa tgagccgcat gaggtcggat agggaggggc caaatgaaac 1341601 aagcgaaaaa acagggggtt ttagagcgtt tctattactc ttcagatgaa atcattgaaa 1341661 agccgtttaa ctgggctcaa atgtggcggc tgctgagcta tgtcaaacca tatcgaaaaa 1341721 caattttgcc gctttctttt ctcactgtat tgattggcac tgctgtgaag cttgtgatcc 1341781 ccattttgat cggcgtttat gttcttgatc aagcgattac agggagaaac tcggagctgc 1341841 tgattcagct catttttatt attagcggtt tatatgtcct caattacgcc gccaatgtgt 1341901 taagaatcag gtggatgaat cagcttggcc agcatgtcat ttacgatttg cgacagcatt 1341961 tatttaccca tgtgcagcgc ttatcccatc gattttttga tcagcggtcg gcgggatcga 1342021 tcttagtcag gatcatgaat gatattaact ctcttcagga gctctttaca agcggagtca 1342081 tcaatttgtt gaccgacttg ctgcttctgg ccggcgtgat tattattttg tttacgctga 1342141 gccctgagct gactatagcc atcatggtga cattgccgat tatgtttttt atttcaacaa 1342201 gtctcagaaa aaaaatacgc cgatcctggc aaacggtacg gctgaagcaa tcgaagctca 1342261 actctcatct aaacgaaagc attcagggca tccgggtcac gcaggcattt acgcaggaag 1342321 aagaaaacat ggcgtatttt gacggtgtca atcaggagaa ctacgaatca tggcgggaag 1342381 caactagaaa aaatgccatg ttccgtccgc ttgtagaaat gacgaatgcg attgggacgg 1342441 ctgtcttgat ttggtatgga gccacactca tcatgaatga aaccattacg attggcgtct 1342501 tcgtttcttt tgctttctat ctgggaatgt tttgggaacc tatttcgaga ctgggtcagg 1342561 tctataatca gctgttaatg gggatggcat catcagaacg gatttttgag tttctggacg 1342621 aacagccaaa tgtcaaggag aagccgaatg ccattcataa tgaaaagata aatggggaga 1342681 tcagttttga agaggttgaa ttttcgtatg atgaaaaacg aaaagccctt cacgccgttt 1342741 ctttctctat tcctgcggga tcgacgcttg cgcttgtcgg gcatacaggg agcgggaaga 1342801 cgacgattgc caatttaatc agccgttttt atgatgcggc cggaggcacc attaaaatag 1342861 acggtatacc gattaaggat ctttcccttg ccagtctgcg ctctcaaatc agcattgtcc 1342921 tgcaagatac atttattttc tccgggacca tcatggaaaa tattcgtttt ggaaggccaa 1342981 atgcttcgga tgaagaggtg atgaaagcgt cccaagcggt cggagcggat gagtttattt 1343041 ccgatttagc ggaaggatac gcaacagagg tagaggaaag gggcagcgta ctgtctgccg 1343101 gtcagcgcca gctcatttca tttgcaagag cattgctcgc cgatccggct attatcatcc 1343161 ttgacgaagc aacggcaagc attgatacag agacagaagt aaaaattcag caagcgttaa 1343221 aaacgcttct gaaagggcgt acagcagtga tgatcgctca cagattgtct acgatccgcg 1343281 acgccgaccg catcattgtt cttgatcacg gcaggaaaat agaagaaggg aaccatgatc 1343341 agctgctcgc taaaggaggc atttatgccg ggcttgtgaa agcgcaatac agcacagcga 1343401 tagaataata tgaaaagcct tcaatattga aggtttttgg aaatttatta gaaaaacatg 1343461 aaactttttg atatccttcc cgtactattt gttagatatt ctcaaggagg ttttgaaatg 1343521 gaaacgaatg tagaaaaaaa cagcggaacg gcgactgaaa agccttcact tttcggagta 1343581 atcacaagtc cgtccgttca atttgaaaga ataagagaaa ggccggctgt atggggaccg 1343641 cttttgattg ttgcagcaat tatcatcgtc ggtgccgtgc tgcaatcact cggtacggat 1343701 tatagtgagc ttttgaaaag ccaggatacg caagggctat ctgctgaaca aatggaaact 1343761 gtcgcaacaa taaccaaatt tggcggaatg gcaggcgcta ttatcggcgg tatcgcagca 1343821 ttatttattg cccctcttat ttattggctc tgtgtaaaag tatcaggcgg tgttacgaca 1343881 tataaaaaaa tgctttctct cagtctgttt gtctctttga ttagcagtct cggattattg 1343941 gttaatggaa tcgttgcttt tacgactgac gtgaatcctc tttacagcac gacgtcactc 1344001 gcagggatta tcccatctga cggggctctc gccagtgtgt taaatacctt tgaaattttc 1344061 agcatctgga gctttgtatt attagcaatc ggacttcaca aaacgggagg catctcaaaa 1344121 aaagccgggt ggatttcagc aatcattcta ttcggaattt tagttgtatt ttcgcttttt 1344181 tcaggtttaa tcaattctgt ggcgggtgca taagctcatg aaaaaagtct ggatcggaat 1344241 tggaatcgca gttatagtcg ctctttttgt tggaatcaat atataccggt ctgccgctcc 1344301 gacaagcggc agcgccggca aggaggtaca gacggggagc gttgaagaaa atgaaatctc 1344361 atcaacggtt atggttcctg gcacgctaaa attttcaaat gaacagtatg tcttttatga 1344421 agcggataaa gggacattag aagacattaa agtaaaggaa ggcgataaag ttaaaaaggg 1344481 cacggcttta gtcacctata caaatgagca gctgagcctg gaaaaagaac agaaccagtt 1344541 aacgtctgaa tccaaccggc ttcaaattga ccaaattcaa gaaaagttaa aagccttgga 1344601 cagcaaagaa agagaactgg aaaaacaggt aggaaagaaa gaagcagaaa aacaaatcga 1344661 atctgaacgg acagagcttc aaatgcagaa aaaaacagcg gagatcgaat taaaacaaac 1344721 cgagcttcag cggcagtcac ttgccaaccg ggtgtcagat ttagaagtga aaagcgaaat 1344781 tgaaggcacc gttatttctg tcaaccaaga agcggcatcc aaaaagtcag atattcaaga 1344841 gcctgtcata catatcggca acccaaaaga ccttgtcgtc tcagggaaat tgtctgaata 1344901 cgatacattg aaagtcaaaa aaggccagaa ggtcacactc acttcagatg taatacaggg 1344961 taaaacatgg aaaggcacgg tttccgcagt cgggcttgtt ccggatcagc aggagagcgc 1345021 tgcggcacaa ggaacagaac aggcggtcca atacccgctt caagtgaaaa taaaaggaaa 1345081 tcttccagaa ggaaagccag gctttaaatt tatcatgaat attgaaacag ataaacggaa 1345141 agcaaatacg cttccttcaa aggcagtcaa aaaagaagat gaccaatatt atgtgtatac 1345201 agtaaaagac ggaaaagcaa agcgagttga tgtcaaaatc ggcgaagtga cagatgacct 1345261 gacagaaatt aaagaggggc ttacccaaga tgatcaagtc attttgaatc catctgatca 1345321 ggtgactgac ggaatggaag tgaaatccta aatgattcag ctttctaatg tgcgaaaaag 1345381 ctaccagatc ggaaaggaaa cgtttgatgt tctccattct attgatttgg acattcatca 1345441 aggtgaatat gtctcgatta tggggccgtc aggatcagga aaatcgacga tcatgaatat 1345501 tatcggctgt cttgatcggc cgacttccgg tacatatcaa ttggacggcg aagacatttc 1345561 ttcatataaa gataaagaac tggcggcagt ccgtaaccgg tccatcggtt ttgtatttca 1345621 gcaatttcag cttcttccgc ggctgaacgc aaaaaaaaat gtcgagctgc cgatgattta 1345681 ttccgggata ggcaaaaagg aacgtcaaga gcgggctgag agagcattgg aaaaggtcgg 1345741 gttagccgat cgaatgctcc acatgcccaa cgagctgtcg ggcgggcaga agcagcgggt 1345801 ggcgattgcg agggcgatcg tgaatgagcc gaaattgatt ttagctgatg aaccgaccgg 1345861 cgcgctggat acgaaaacaa gcgaggcgat tatggatcag tttacagcat taaatgccga 1345921 gggaacgaca atcgttctgg ttactcacga gcctgaagta gcagattgca cgaatcggat 1345981 cgtcatggtg cgtgacggaa acattgttcc tgccagctcc ggacaaagga gtgtgggaga 1346041 atgagcctgt tggaaaacat cagaatggct ctaagctctg tccttgccca taaaatgcgt 1346101 tcgatcttaa cgatgctcgg cattatcatt ggtgtaggct ctgtcattgt tgtcgttgcg 1346161 gtaggacagg gcggcgagca aatgctgaag cagtcgatca gcggcccggg aaatactgtg 1346221 gagctgtact atatgcctag cgacgaggag cttgcaagca acccgaatgc cgcagctgaa 1346281 tctacgttta cagaaaacga tattaaaggt ttaaaaggaa tagaaggcat taaacaagtc 1346341 gttgcttcga cttctgaaag tatgaaagcg cgttatcacg aagaagaaac cgatgctacg 1346401 gttaacggaa taaatgatgg atacatgaat gtcaattctt tgaaaatcga aagcggcaga 1346461 acctttaccg acaatgactt tctcgcgggg aatagagtcg gaatcatctc tcaaaaaatg 1346521 gctaaagagc tgtttgataa aacctcccct ctaggtgaag ttgtctggat taacggacag 1346581 cccgttgaaa ttatcggcgt gctgaaaaaa gtaacaggct tgctttcttt cgatttaagt 1346641 gaaatgtatg tgccatttaa tatgatgaaa tcctcttttg gcacaagtga tttcagtaac 1346701 gtatcattgc aggtcgaatc agcagacgac ataaaatcgg ctggaaaaga agcggcacag 1346761 ctggtaaatg acaatcatgg cacagaggat tcgtatcaag tgatgaacat ggaagagatt 1346821 gcggccggaa ttggcaaagt aactgcaatt atgacgacga ttatcggctc aattgcaggt 1346881 atttcccttt tggtcggcgg aatcggtgtc atgaatatta tgctcgtatc agtcacagaa 1346941 cggacgcggg aaatcggaat cagaaaatca cttggtgcga cgaggggaca gattctgact 1347001 cagtttttaa ttgaatcagt cgtattgacg ctgattggcg gtctggtcgg gattggtatt 1347061 ggatacggag gggccgcgct tgtttcagcc attgcgggct ggccgtcact catatcctgg 1347121 caggttgtat gcgggggcgt gctgttcagt atgctcattg gtgttatttt cggcatgctt 1347181 cctgcaaata aagccgcaaa gcttgatccc attgaagcgc tgcgttatga gtagcctcat 1347241 gcaacatgca tgaggttttt ttatgtttag tgatttctac tatgaatata aaagactttt 1347301 ttcattaaaa taagaagaaa atgtcgtaca attgtcctta tttttgtcga atttacagtt 1347361 tacaaaccct atagacatac gttaatatgg agaaacgtga aagattttga tagttattga 1347421 atgaatttga atgattttag ttgcctaaac cgaaaatagc gtttacaatg aaattgtatt 1347481 caaaatgaat acgttttcat taggaggtga agcatgctaa ctcctgaacg gcatcaattg 1347541 attattgatc aaatagaaaa gcatgatgtg gtaaagattc aagagcttat aaatctgact 1347601 aatgcttctg aatcaacaat cagaagagat ttatcgaccc ttgaagaacg cggtttttta 1347661 aagcgcgttc atggtggagc ggccaagctt tccgatatca gacttgaacc cgatatgctt 1347721 gaaaaatcat ccaaaaacct tcacgataaa ctgaagattg ctgaaaaagc tgcttctctt 1347781 ttagaagaag gggattgcat ttaccttgat gcaggcacga cgacattgca catgattgat 1347841 tttatggata aaaccaaaga tattgtcgtt gtcacaaacg gggtaatgca tatcgatgca 1347901 ttaataagga aagaaatttc tttttatctg cttggaggat acgtaaagca cagaacgggc 1347961 gcgattattg gaggcgcttc attggttgcc atggaccagt acagatttga caagagtttt 1348021 ctggggacaa acggtgtcca tacagaggct ggatttacaa cgccggaccc tgatgaggcc 1348081 cttttaaaac agaaagcgat caaacaggca aaacacgctt acgtcttagc agacccttcg 1348141 aagttcggag aaatttcatt ttcggcattc gccggaatag gcgacgcaac aatcattacg 1348201 actgacgctg aagagcttac attcgataat taccaagaaa aaactgtcgt aaaggtagtg 1348261 aaaccatgat ttacactgta acacttaatc catctgtcga ttatatagtt cacgttgaag 1348321 attttactgt aggaggcctg aaccgttctt cgtatgatac caagtatcca gggggcaaag 1348381 gcatcaacgt atcgagactg ctgaaaagac accatgtggc gtctaaagcg ctcggattcg 1348441 tcggcggatt taccggagaa tatatcaaaa catttttacg ggaagaaaac ctggaaacag 1348501 ctttttctga agtaaaaggg gatacccgta tcaatgtaaa gctgaaaacg ggtgatgaaa 1348561 ctgaaattaa cgggcaggga ccgacaattt cggatgaaga tttcaaagcc tttttagaac 1348621 agttccaatc tttgcaagag ggagatatcg ttgttcttgc aggaagcatt ccatcttcac 1348681 tccctcacga tacttatgaa aaaatcgcag aggcctgcaa acagcagaac gcacgagttg 1348741 ttctggatat ctcaggcgag gctcttttga aagcaacaga aatgaaacca tttttgatga 1348801 agccaaatca tcatgagctt ggagaaatgt tcggcacggc cattacatct gttgaggaag 1348861 ccgttcctta tgggaaaaag cttgtagaac aaggcgctga acatgtaatc gtatcaatgg 1348921 ccggagacgg agcgcttctg tttacgaacg aagctgttta ttttgctaac gtgccaaagg 1348981 ggaaattggt aaactcagtc ggagcagggg attccgttgt tgcaggtttc cttgccggaa 1349041 tttccaaaca gctgccgctt gaagaagcat tccgcttagg agttacttca ggcagtgcta 1349101 ccgcgttctc tgaagaactt ggaacagaag aatttgtcca gcagcttctt cctgaagtta 1349161 aggtcacacg tctatagagg aggaaacaca agtgaaaata actgagcttt taacgaagca 1349221 tacgataaag cttaatattg agagcaaaga aaaagaaaat gttattgacg aaatggtcac 1349281 tgttcttgat aaggctggaa agttaaatga ccgacaagcc tataaagaag ccattttaaa 1349341 tcgcgaaagc caaagctcca cgggtatcgg tgaaggaatc gctatccccc atgcgaaaac 1349401 ggcaagcgtt atcaacccgg cgatcgcgtt cggacgttca aaagacggcg tcgattatga 1349461 atcattagac ggccagccgg ctcacttagt gttcatgatc gcggcgactg aaggcgcaaa 1349521 caacactcac cttgaagcat tgtcaagact ttcaacgctg ttaatgcgtg aagaaatccg 1349581 taagcagctc cttgaagctg agtctgaaga tgccatcatc gacattatta atcagcacga 1349641 taaagatgat gacgaagagg aagaggaaga agaagcggca ccagcacctg ccggaaaagg 1349701 gaaaatttta gcggttactg catgcccgac aggtattgcc catacattca tggctgcgga 1349761 tgcccttaaa gaaaaagcga aagagcttgg tgtggaaatt aaggtcgaaa caaatgggtc 1349821 aagcggcatt aagcacaagc tcactgccca agaaatcgaa gatgcacctg caatcattgt 1349881 cgcagcggac aagcaggttg aaatggaacg ttttaaaggc aagcgcgtac ttcaagttcc 1349941 tgtaacggcg ggtatcagac gtccgcaaga gcttatcgaa aaagcgatga atcaagatgc 1350001 gccgatttat caaggcagcg gcggcggttc agcagcttca aatgatgatg aagaagcgaa 1350061 aggcaagtct ggaagcggta tcggaaacac gttttataag cacctgatga gcggtgtcag 1350121 caacatgctt ccgttcgtag tcggcggcgg tattctcgtt gcgatttcat tcttctgggg 1350181 aattcactct gctgatccga atgatcctag ctacaacacg tttgcagcag cattaaactt 1350241 tatcggcggc gacaatgcat taaaactcat tgttgcagtt ctggccggtt tcattgcgat 1350301 gagtattgca gatcgtcctg gttttgcgcc tggtatggtc ggcggattta tggcaactca 1350361 agcgaatgct ggattcttag gcggcttaat tgccggattc cttgccggtt atgtcgtgat 1350421 tttactgaaa aaagtattta cgtttatccc tcagtcactt gatggattaa aacctgtttt 1350481 gatttacccg ctgttcggta tttttatcac tggcgtatta atgcaatttg tcgtcaatac 1350541 acctgtagcg gcatttatga atttcttaac aaactggctt gaaagccttg gtactggaaa 1350601 ccttgtgtta atgggtatta tcttgggcgg catgatggcg atcgatatgg gcggtccgct 1350661 taataaagca gcctttacgt tcggtatcgc catgatcgat gcaggcaact atgcgcctca 1350721 tgcagcaatc atggccggcg gtatggttcc tccgcttggt atcgcacttg caacaaccat 1350781 tttcagaaac aaattcactc agcgtgaccg tgaagctggt attacatgct atttcatggg 1350841 agctgctttc gtaacagagg gagcgatccc atttgctgcg gctgatccgc ttcgcgtcat 1350901 accagctgct gtagtcggtg cagctgttgc cggcggatta actgaattct tccgagtaac 1350961 gcttccggcg cctcatggag gagtattcgt agctttcatt acaaaccatc cgatgcttta 1351021 ccttttaagt atcgtgatcg gtgctgtcgt gatggcaatt atcctcggta tcgtcaaaaa 1351081 acctgttaca gaaaaataag aaaaaaagcg tccttggttc gaaaggacgc tttttcttat 1351141 ccggccggca gggagcgcgg ttaagttatg tattttattc ttttttatga taaagtaaaa 1351201 gaagagaaac aactgacata gcaattgtct aggaggaaac actttgaccg aggaaaaaaa 1351261 tacgaatact gagaaaacgg cgaagaaaaa aaccaatacg tacctggaat ggggtaaagc 1351321 gattgtcatc gctgttctgc tggctctcct gatccgtcac tttttgtttg aaccgtattt 1351381 agttgaaggt tcatctatgt atcccacatt acatgacgga gaaaggctgt ttgtgaataa 1351441 aacagtcaac tatatcggcg agctgaagcg cggagatatc gttattatca acggtgaaac 1351501 ttctaaaatc cattatgtaa aaagattgat cggaaagcct ggagaaaccg ttcaaatgaa 1351561 ggatgacacg ctttatataa acggtaaaaa agtagccgag ccttacttgt ctaaaaacaa 1351621 gaaggaagca gaaaaacttg gtgtcagtct gacaggagac tttggaccgg ttaaggttcc 1351681 gaaaggcaaa tactttgtca tgggagataa ccggctgaat tctatggaca gccgaaacgg 1351741 gctgggactg atcgcggaag atcgaattgt cggcacatcg aagtttgtct ttttcccgtt 1351801 taacgaaatg cgtcaaacaa aataaaaacg ccttgctggc ctaggacagc aggcgttttt 1351861 attttgaaaa agaagcgacc aatgcaatgc ataaaaccgt gatgaacact gaaccgataa 1351921 tagccagcac actgaagaaa aggtgaacct gtttgttctc ttttccgcgc ttttctaata 1351981 gccgtttaga aaaaatgtgc gaaaatatgt aaataagggc tatgcctata tataagccga 1352041 tatctttggc ggtaaagcct gttacggcaa ggtaaaagcc cgtaaaaaag atcagtaagc 1352101 aatattcagt aagtgttaaa agcctcaacg tgttcctcca tgagagtgtg taattttcca 1352161 ggcggatgca ttctctctct ttaattgtaa cacagctggc tggtttgggt gtataagtgt 1352221 tttctctctg ttttatcagg gaatcatttc tcttgccctg cattcatggt atacttttat 1352281 tgatgataga catgatggag gataataaat gattgctgta aataatgtaa gcttgcggtt 1352341 tgcggatcgc aagttatttg aagatgttaa tattaaattt accccaggca actgctatgg 1352401 gttaattggt gcaaacggtg ccggtaaatc aacgtttcta aaggtgctgt caggcgaaat 1352461 cgagcctcag acaggcgacg tgcatatgag tcctggcgag cgtcttgccg tcttgaagca 1352521 gaaccatttt gagtacgaag agtatgaagt gctgaaagtg gtcattatgg gccacaaacg 1352581 cctgtatgaa gtcatgcagg agaaagacgc tatttacatg aagcctgatt tctcagatga 1352641 ggatgggatt cgtgctgctg agctagaagg tgaattcgcg gaactgaacg gttgggaagc 1352701 ggaaagtgaa gctgcgatcc tgttaaaagg ccttggtatc tcagaagatc tgcacacaaa 1352761 aaagatggca gacctcggcg gttcggagaa ggtaaaagtt ctcttggcac aggcattatt 1352821 cggcaagccg gatgttctgc tgctcgatga gccgacgaac cacctggacc ttcaggcaat 1352881 tcagtggctt gaagagtttc tgattaactt tgaaaacaca gttattgtcg tatcccatga 1352941 ccgtcacttt ttaaataaag tatgtacgca cattgccgac cttgatttta acaaaattca 1353001 aatctatgtc ggaaactatg atttctggta cgagtcaagc cagctggcgt taaagctttc 1353061 tcaagaagcg aacaagaaaa aagaagagca gattaaacag cttcaagagt ttgtcgctag 1353121 attcagcgcc aatgcgtcta aatctaagca ggctacatca agaaagaaac ttctcgaaaa 1353181 aatcacgctg gatgatatta aaccgtcttc ccgccgctat ccttatgtta acttcacgcc 1353241 ggaacgggaa atcggaaatg atgttcttcg cgtggaaggc ttaacaaaaa caatcgatgg 1353301 cgtaaaggtg cttgacaatg tcagctttat tatgaatcga gaagataaaa ttgctttcac 1353361 tggccgaaat gaacttgctg ttactacgct gtttaaaatc atttccgggg aaatggaagc 1353421 tgacagcgga acgtttaaat ggggtgttac cacatctcaa gcgtattttc caaaagacaa 1353481 cagcgaatat ttcgaaggca gtgatctgaa ccttgtagac tggcttcgcc aatattctcc 1353541 gcacgaccaa agtgagagct ttttacgcgg tttcttagga cgcatgctgt tctctggaga 1353601 agaagtccac aaaaaagcaa atgtactttc cgggggagaa aaggtccgct gtatgctgtc 1353661 gaaagcgatg ctttctggcg ccaatatttt aattttggat gagccgacca accatttaga 1353721 cctagagtcc attacagcgc tcaataacgg cttaatcagc tttaaaggcg ctatgctgtt 1353781 tacttcccat gaccatcagt ttgtgcagac cattgccaac agaattatag aaattacacc 1353841 taacggcatc gtcgataagc aaatgagcta tgacgagttc cttgaaaatg ctgatgtgca 1353901 gaaaaaattg actgaactat acgccgaata aaaaagcaga gatttctctg ctttttttga 1353961 tacctaaatg tgaaaggaga tcacaacatg aaatttttgg ttgtcggagc aggtggagta 1354021 ggcgggtata ttggcggacg gctttcggag aaaggaaatg atgtgacatt tctcgtgcgc 1354081 caaaaacgag ctgagcagct taaaaaaacc gggcttgtca tccatagtga aaaagggaat 1354141 gtatcatttc agcccgaact aatcagtgcc ggagaaacag ggcaatttga tgtcgttatc 1354201 attgcttcta aagcatactc gcttggtcaa gtgatagagg atgtcaaacc atttatccat 1354261 caagaatctg tcattatccc ttttttaaat gggtaccgcc actatgagca gctatttgcg 1354321 gcattttcaa aagaacaggt gctgggcggc ctgtgtttta tagaaagtgc tttagacaac 1354381 aaaggagaaa ttcatcatac gagcgcatcg catcgttttg tatttggaga atggaacggc 1354441 gagcgtacgg agcggataag agcgcttgaa gaggcatttt caggtgtgaa ggctgaagtc 1354501 atcattagcg ggcatatcga gaaggacatt tggaaaaagt atctctttat tgcagcgcaa 1354561 gcggggatca caacgttatt tcaacgaccg cttggcccaa tcctcgccac agaagccgga 1354621 cgtcacacgg cccaaactct tattggggaa atttgcactg ttttacgaaa agaaggtgtt 1354681 ccggctgatc cggctcttga ggaagagagc tttcgtacga tgaccagcat gtcttaccat 1354741 atgaagtcct ccatgcttcg ggatatggaa aacggccaaa cgacagaagg cgaccacctg 1354801 catggatttt tgattgaaaa agcaaaacgt ttatctctcg ctgcaccagt attagaaacc 1354861 gtttatgcga atctgcaaat gtatgaagca gaaaaataaa aaaaggaggc ggaaaagcct 1354921 ccttttattt acttaaaaag cccaatttcc gtttctgaag ataggctctc ttttcccgtc 1354981 tgccgtaatt ccgtcaatat tcatatcctt agaaccgatc ataaagtcca cgtgtgtaat 1355041 gctttcattt aggccttctt tgacaagctc ttcacgagac atctgctttc cgccttcaat 1355101 attaaaggca taggcgcttc cgatcgccaa atgatttgac gcgttttcat caaacagcgt 1355161 gttatagaaa agaatgtttg attgtgatat aggcgaatcg taaggaacaa gtgccacttc 1355221 acctaaatag tgagaacctt catctgtttc caccagttct tttaaaatat cctcaccttt 1355281 ttcagcttta atgtcgacta tacggccatt ttcaaacgtc agggtgaaat tttcaataat 1355341 atttccgccg tagcttaatg gttttgtgct tgataccact ccgtcaaccc cgtctttttg 1355401 cggcagcgtg aacacttctt ctgtcggcat attggccata aactcatggc cactttcatt 1355461 cacgcttccc gcacctgccc aaacatgctt cctaggcagc ttaattgtta gatcagttcc 1355521 ttctgcttga taatgtaagg cagcgtaatg tctctcgttc aaatggtcaa ctttttcatg 1355581 aagattttgg tcatgattga tccacgcctg aaccgggttg tcttcattta cgcgcgtcgc 1355641 tttaaaaatt tcttcccaca gaaggtggat cgcttcctcc tctgatttgc caggaaacac 1355701 cttgtgagcc cagcctgctg atgccgcacc tacgacagtc cagctgactt tgtctgattg 1355761 aatatattgt ctgtatgtat gtaatgcttt gcctgctgct ttttggaatg ccgcaatccg 1355821 tttggaatct atacctttta gcaagtctgg gttcgacgac acaacagaaa tgaaagcagc 1355881 tccatttttg gcaagctctt ctctgccttt tgcttcccat tcaggatatt cttcaaatgc 1355941 ttcaaacggc gcaagttcgt attttaattt ggcgacttcg tcatcctgcc aattcacggt 1356001 gacgtttttt gcgccctttt catatgcgtg ttttacaatt aaacggacaa aatcccgaac 1356061 gtctgttgaa gcatttacga ctacatactg gcctttttgg acattaacgc cgacttctac 1356121 cgccagctgt gcatatgtat ttaatttctg tgaaaatgaa tccatgaatc attcctccaa 1356181 gcttttttct catcatatca aatatgatcc tataaaggaa agaaggagcc caaagtgaaa 1356241 aacccaaaac gacacgtctt gggttttttc aatattatgg atgattcagt tttacagtgc 1356301 cgcctgcagg cgaatggggc atatttgcca aagaaatgct catgcctcca agaataattc 1356361 cgcttaaaat ggctgcgatc gctactcttc ttcctaaatc tcttagcatc tgtttcctcc 1356421 ttaacgtttc tccatttccc acaatatgaa ggaagtgagg aaaaaagaag caagaaattt 1356481 gccgcgtgtg agaattttgc gggtaaagac tatttaattg ccttttgcag cttatcaatc 1356541 acttctaaag aacggcctgt gccgattgct acagattcaa gcgggttttg cgccacgtgt 1356601 acaggcacga caatctcttc tgtgagccat tctttaattc cattaaggag cgcgccgccg 1356661 cctgttaaaa taacgccgcg atcaacaata tctccgctca attcaggcgg acagtcctca 1356721 agtgtcgctc tgatggcttc aagaatatgc aggagggatt cacgcattgc atcttgaatt 1356781 tcgttggatt gaagcataat ggtttttgga agacctgtca cgaggtcacg tccccgaatt 1356841 tccattgcct ctggtatatg ttcaatcaga gcatggccaa tttccatttt tacctgctca 1356901 gctgtgcgtt cgccgatcag caaattgtat tttttacgga cgaaagaaac gatatcctca 1356961 tcaagctggt ctccgccgat cctgatagaa tggcaggaaa caacgccacc gaaggaaata 1357021 atagcgacct ctgtcgtccc tccgccgata tctactacca cattggcaac cggctcatca 1357081 accggtaaat ccgctccgat ggcggctgca actggctctt cgattaaatg aacgtttttc 1357141 gcgccgcaat ttttcaccgc atcactgatg gcgcggcgtt ctactgctgt tgagcctgat 1357201 ggtgtgcaaa cgactacgtt cggttttctg aacgacatgc cgatgctttt tgcggctttt 1357261 ttcataatgt gctttagcag gtcagttgtc atatcatagt ctgcgatcac gccatctttc 1357321 atcggtctga cagcgacaat ttttcccggt gttttaccga tcatgttttt cgcgtcagct 1357381 ccgattgcaa gcactgcttt tgtcgtcgta tccactgcga caacagatgg ttcatttagg 1357441 ataatccctt tatttttgct gtaaacaagt atattagctg ttcctaagtc aatcccgatt 1357501 tcagttgatt gaaacatgtt ttcacccaat ctctatccta atttaatatg attctacatt 1357561 taaagtttct cagaaatact gcgatttttg ggggtgtgcg tcggtaaaga aatgtttttg 1357621 taaaaaatca aggaactgtg taacagaagt aatacatttt tcggttttat ggaaaaaata 1357681 tcttgtaatt cttatagaaa gcgggaaact ttttcaaagt ttcattcgtc tacgatatat 1357741 tgaggtacat ccttaaaaca ttacatgaga aaagaaacat ttaaaggaag aagggttttt 1357801 atgaaatcaa taggtgttgt gagaaaagta gatgaattag gccgcattgt catgccgatt 1357861 gagttgagac gggcattgga tattgccata aaagacagca ttgagttttt tgttgacgga 1357921 gataaaatta tcttgaaaaa gtacaaacct catggcgttt gtttaatgac tggagaaatc 1357981 acttcagaaa ataaagaata cggcaacggt aaaattacgc taagccctga gggtgcacag 1358041 ctgcttctcg aagaaattca agccgcttta aaagaataaa attatgctaa aaaaggcgga 1358101 gtgatatcat ctccgccttt tttgcgtgcc aatttttgat taccgccgcc taagataaga 1358161 catcaagata tttggtaatg aatgatttgg gatactttac atattttact caattatttg 1358221 tcgaagaatg gtacaataag tagagaaaca caagcggcag gtggtcatat gagaaaatat 1358281 caagctcgta tcatttccat cattttggca atgattttta taatgttttg ggattattta 1358341 ttttatttta taggcaaaaa cccgattaat tggcctgttg atattgtgta tactgcagtc 1358401 acgctggtaa gtgtctggat gttggcttat tatattgatg agaaacagca gctggttaag 1358461 aaaatgaagg ataacgaatg gaagtataaa cagctttctg aagaaaaaaa ccgcatcatg 1358521 gataatttgc aggaaatcgt atttcaaacg aatgcaaaag gtgaaattac atatttaaac 1358581 caagcgtggg catctataac cgggttttca atcagtgaat gtatgggaac aatgtataac 1358641 gattacttca taaaagaaaa gcacgtagcc gaccacatta acacccaaat ccaaaacaaa 1358701 gcgtcttctg gcatgtttac ggcaaaatac gtgacaaaaa acggcacgat tttttgggga 1358761 gaagttcatt ataaacttta ctatgaccgg gatgaccaat ttacaggcag cctgggtaca 1358821 atgtcagata tcactgagcg gaaagaggct gaagatgagc tcattgagat taatgaacgg 1358881 ctggcgaggg aatcccagaa actatcaatc acaagtgaac ttgccgcagg tattgctcat 1358941 gaggtcagaa accctttaac atctgtcagc ggtttcctcc agattatgaa aacacaatat 1359001 ccggacagaa aagactattt tgacatcatc ttttcagaga ttaaaagaat cgatttagtg 1359061 ctcagcgagc tgctgctgct tgcaaaaccg caggcaatca catttaaaac acaccagctt 1359121 aatgagatct tgaaacaagt cacgacattg cttgatacca atgcaattct gtccaatatc 1359181 gtcatagaga aaaatttcaa agagacagat ggctgtatga ttaatggaga cgaaaatcag 1359241 ctgaagcagg tctttatcaa catcattaaa aacggaattg aggcaatgcc aaagggcggt 1359301 gtcgtaacca tttcaactgc taaaaccgcc tctcatgcag tgataagcgt aaaggatgaa 1359361 ggaaacggca tgccgcagga aaagctgaag cagattggca aaccttttta ttcaacaaaa 1359421 gaaaagggca ctggactggg acttcccatt tgtttgagaa tcctgaagga acatgacggg 1359481 gaattgaaaa tcgaaagtga agctggaaaa ggcagcgtct ttcaagtggt tttgccttta 1359541 aaatcagaca gctgagagga gaaaaataaa gtgaactcgc ttctgtttgt atacgggaca 1359601 ttaagaaagc atgaaaaaaa ccatcatttg ctggcacaat cggcatgtat caatgagcag 1359661 gcgagaacaa agggaagttt gtttgctgca aaagaggggc ccacagttgt tttcaatgat 1359721 gaagatgaag gctatatata tggcgaagta tatgaagcag atgaattgtg tatacataag 1359781 ctcgatcaat tttttcaagg atatcataaa caaacggtgt ttgtagaaac ggatgtcggg 1359841 attaaaattg cgcttattta ttttatgaac aaagacgggt gtgccggttt tacgaaaata 1359901 agcagcggcg actggaaaga acatcagatg atcagcaaat cgaaaaatcc catttattat 1359961 tttgcctatg gatcatgcat ggataatgcc cgctttcaaa aagcgggagt cgatcactat 1360021 tttcaagatc cagtaggaag agctgtttta aaaggataca caacccgctt cacgctaaaa 1360081 agggaagacg gttcaagagc ggacatgttg gaagacggag gaacaacaga aggcgtttta 1360141 taccgtatcc cttattctgc tctctcctat ctatataaaa gggagggcgt cgaatctctt 1360201 acgtatcggc cggcatttgt agacgttgaa gctggcggaa ggcactacaa agactgttta 1360261 acctttctcg tcctccaaaa agaagcggaa attgccccgc ctcagcacta tcagattgaa 1360321 atcgaacgcg gagcggagct gtatttgtcg cctgagttta ctgaaaagct caagcggcat 1360381 atgaattcgc tgccaaaagg ataacactgt aacaaaagaa tatgataaaa tttgatcaat 1360441 atcatgtcat ataaaggagc accacgatga aaaaagaatt tgcggtaatt gggctgggcc 1360501 gttttggtgg cagtatttgc aaagcattaa gcgaagaagg cgtcgaggtt atggcaatgg 1360561 atatcgatga agataaagtc aacgagtatg ccaagattgc atctcacgca gttatcggtg 1360621 attcgacaga cgaatctgtc ctgaaaaatt taggcctgcg aaattttgac cacgttattg 1360681 tagcaatcgg ggaaaatatt caagcgagta ttttaacgac actcattctg aaagaacttg 1360741 gcgtccatac gattacagtt aaagcgcaga acgattatca cgaaaaagtg ctgtctaaaa 1360801 ttggtgcgga tcacatcgtc cacccggaac gcgatatggc aaaacgaatt gcgcataata 1360861 tcgtgtccaa caatgtactt gactatttgg agctgtctga agagcatagt cttgttgaaa 1360921 tcgtagctaa cagccgcctg gctggaaata cgcttctcga tttagatatt cgcgcaaaat 1360981 acggtattaa catcgtagcc ataaaaaggg gcaaggaagt catcgtatca ccgcttgcaa 1361041 ccgaagtcat ccaccaagaa gatatactca ttgttattgg atcagttaca gacatctccc 1361101 gtttcgaaaa aagagttctt catacaaaat agcagccaaa taagccgtcc tcaaagggcg 1361161 gtttttcata ttatcagaat ataacaactt taatgaactg agcgtcaatt tcttaaaatt 1361221 tcattgacta agcacaggcg ttccgatagc atattgtacc atataataaa aaaaggaggg 1361281 gcctatttga ataaagaagc gctagtcaat aggctgaatg cttcagccaa aagacaaaaa 1361341 gctgatatcg tcattaaaaa cggaaaaatc atggacgtat ataatcaaga atggatatat 1361401 gaagatattg cgattacaga tggagttatt gtaggcctcg gtgagtatga aggcgaaaat 1361461 atcattgatg cagagggaca aatgattgtt ccgggtttta ttgatggaca tgtacatatt 1361521 gagtcgtcaa tggttacacc gattgagttc gctaaagcag tgttgcctca tggcgtgacg 1361581 acggttgtta cagatccgca tgagatcgcg aatgtgtctg gtgaaaaagg gattgagttt 1361641 atgcttgaac aagctcggca tacaccgctg aatatccatt ttatgcttcc ttccagtgtg 1361701 cctgccgcaa gttttgagcg atcaggcgca attctcaaag ctgccgatct caagcctttt 1361761 tatgaagaag aagaagtatt agggctggct gaagttatgg attatgtgtc ggttcagcag 1361821 gctgaaaaag acatggttca gaaactgctt gatgcccgtg tggcaggaaa aaggatagac 1361881 ggtcatttag ctggtttatc aacagacctc attaacattt acagaaccgc atttgtctta 1361941 aacgaccatg aagtaacatc gaaggaagaa gcccttgatc gtatcagaag gggcatgtat 1362001 gtcatgatgc gtgaaggatc agtcgccaaa aacacgctca atgtgctgcc ggcggtgaat 1362061 gaaaagaacg cacgccggtt ctttttctgt acggatgata agcatgtgga tgatttattg 1362121 tcagagggaa gtgtaaacca tcaggtgaaa atggcgattc aagccggact taatccgttt 1362181 ttagcctatc agctaggaag cctcaatgca gccgaatgct acggattaga tacaaaggga 1362241 gcgattgccc cgggttttga cgctgatttg ctttttgtat ctgatctgga aaatgtcact 1362301 gtcacaatga cgatggtaaa agggcagact gttgctgaag acagcaaagc ggtctatcag 1362361 gatcatgctt caactgcagc accagatcag gcactgcttg attctgttaa gcttgctgct 1362421 cctcttaaca aacaggattt tcatatgcca atcgattcag agcagcagat caatgtcatt 1362481 caaatcatac caaatcagct tgaaacacga ttagtacaag ttccggctcc tgttgcccgc 1362541 gaatttgagc ctgacactga gcttgatttg ttaaagattg cagttgtcga gcggcataaa 1362601 ggattaaaag aaaccggact tggtgttgtg aaaggttttg gattcaagag cggagcgatt 1362661 gccacaacca tttcacacga ctcccataat attattgccg tcggaacgaa tgatgaggat 1362721 atcgcggcgg cagttaataa gctgcaggaa attggcggag gattaacaat tataaaaaat 1362781 ggggaagagc tccattcagt accgctgccg attgcagggt tattatccga ccaatctgca 1362841 gagcaagtga atcaaagctt gctgacgctt catgataaat tgtcgttaat cggtttcaca 1362901 ggcggattta atccattttt gacattgtcg tttttagcgt tgcctgtcat tcctgatatt 1362961 aaaatgacga ctacgggatt attcgatgta aaatcatttc aacacatatc actgcaataa 1363021 aaagaggcac tcccttaggg agtgcctctt tttttaaacc tccataatga tcggcaggat 1363081 cattggacgg cgctttgttt tttcgtacaa gaaaggtgca agcgtgtctg taatttcgtt 1363141 tttgatttca gaccattgag tcgtttttcg ttccattact ttttgtaagt gatttgaaat 1363201 gagctcttga gcgtcgttga tcaagtcacc agattctctc atgtacacaa atcctctgga 1363261 aatcaaatca ggacccgctg aaatcttgaa gtcgtccatg tcaatgctga caacaacgat 1363321 gacaagtcct tcttcagaga gaattctgcg atcacgaagt acgatattgc caatatcacc 1363381 gataccgctt ccgtcaatgt acactgaacc ggacgggatt tttcctgcaa ctgaagcctc 1363441 atcgccttta agtgctaata cttcaccatt atccatgata aagcagtttt cctctgggat 1363501 gccacaatct gttgcaagtt tgacatgcat cttttgcatt ctgtactcac cgtgaatcgg 1363561 catgaagaat ttaggcttga ttaaacgaag catcagcttc tgttcttcct gtccgccgtg 1363621 accggatgta tggatatcgt taagagggcc gtgaataacc tcagcacccg cacgatacag 1363681 ctggttgatt gttcgactca cgctgattgt gttgcctggg ataggggatg aagaaaatac 1363741 gactgtatcc ccaggattga ttgaaatttg gcggtgtgtg ccgtttgcaa ttcttgataa 1363801 cgccgccatt ggttcccctt ggcttcctgt acataaaatt gttactttat tagcaggcat 1363861 acgattgatt tcgttatgct caataaacgt atttttagga cagttaatat aaccgagtgt 1363921 ctgtccaatt tcgatagccg attccatact gcgtccaaat acggcaactt ttcttccatt 1363981 ttgtacagca gcttcaatta cctgctgcaa gcggtgaata ttcgacgcaa atgtggcgaa 1364041 gataattcgg ccgtccacct tgcggaaaat gtcatgaatg ctttctccta cacggcgctc 1364101 agacatggta aactccggat tttcactgtt tgtgctgtct gaaagaaggc acaaaacgcc 1364161 ttctttaccg atttcggcca ttttcgttaa gtttgccggc tcgccgactg gagtaaagtc 1364221 gaatttgaaa tccccagtat gtacgatgtt tccgggcggc gtttttacaa caatgccgta 1364281 ggaatccgga atactgtgtg ttgttctgaa gaatgacaca gccgttttgc ggaactttac 1364341 aatatcatcc tcgccgataa tgttcagttt cgtctgtctc aataatccat gctcttcaag 1364401 tttattccga agtaagccga tcgcgagttt tccgccgtat acaggaatat tcacttgtct 1364461 gagcaggtat ggaataccgc cgatgtggtc ttcgtgcccg tgggtgataa aaagcccttt 1364521 aattttatct tcgtttttga ctaaatacgt ataatcaggg atgacgtagt caattccgag 1364581 cagttcgtcc tcgggaaact tgatccccgc atcaatcagt acaatttcat cctggaattg 1364641 caccgcgtac gtatttttac cgatttcgcc caaacctccg agggcgaaaa cagcagtctg 1364701 atcatttttt acaaatttca taccgctcat aactccaata ctttaaaatt ttcgctctgt 1364761 tgttcatatt ctaagaatgc accatcaaca ggtgtaataa actcaatatt aaatttcttt 1364821 tctttcagct ttgttctgac gtcacgctca gatacgcctt caatataaag tgaatctgtc 1364881 ttttcccgaa caggtacttc gtcagccttc tcttgataaa ataccttata aatcattcca 1364941 aatctctcct taaatgccgt atgttagact cgctcattct attatattcg aaaacggaat 1365001 ataaggaaag ccttgagcaa aataaggatc tctcaaaaag tgaaagatcc cttgtcaggc 1365061 aattgctttc ttacggagca ttccgttcca ttgtcttctg agtttctttc ttaatttacg 1365121 cagcattagc cagtccctcc tttaatgaaa aatttgtccc agagttcttt tatacaaata 1365181 gtatacggag attgaggaag acttttcgtg gttattaatg gaatttaata tgatttttga 1365241 acgaaattgt ttgctgaatg acaatctttt tgtatgatga gggtgggaat tgcagaccaa 1365301 gacgataaag gggaagttgc gatggattct aaattaatct tttttgatat tgacggcaca 1365361 atatatgatc atgataagaa tataccggaa agtacgagaa aaaccgtggc ggagcttcag 1365421 cgccaagggc atcatgtgtt tattgccagc ggccggtctc catttttggt taagccgatt 1365481 ttggaggagc tgggcatcca ctcatttatt tcctacaatg gacagtttgt tgtctttgaa 1365541 aatcaagtga tttataaaaa tccgctgcct gaaaatgcaa tcaggcgatt attaaagcag 1365601 gcggatgaag gcaagcatcc tgttgtgttt atggctgagg acacgatgaa agcgactgtt 1365661 gcggatcacc cccatgttct cgagggaatc ggcagcctta aaacagatta tccagagacc 1365721 gatgaccttt tttatgaagg aaaagaaatt tttcagcttc ttttattttg tcaggatgaa 1365781 gaagaaaaag cttatgccgc ttttcctgag tttgatctag ttcgctggca tgagctatcg 1365841 actgatgttc tgccgcacgg aggttcgaag gcagaaggaa tcaaaaaagt gattgagcgt 1365901 cttccgtttg atatcggcga tacatatgct ttcggcgacg gattaaatga tttgcaaatg 1365961 attgaatacg ttgggacagg cgttgctatg ggaaatgctg ttcccgaact gaaagaaatc 1366021 gcggactttg taacaaaacc ggtggacgag gatggaattg catacgctgt caaagaattg 1366081 ggccttttaa aataaagaaa cggctggcat tgtgccagcc gttttctctt ttagcgctca 1366141 attgcgattg cattttcagg ttctttgaaa ggattttcct tatcaatatg atcatagaac 1366201 ataacgccgt tcaaatgatc gatctcatgc tgaaacacaa tagccggaaa tccttttaaa 1366261 cgaatatcaa tattttcgcc ttctagtgtt gttcctttta ctctgatgcg agcatagcgg 1366321 ggaacataac cgggaatcgc ttcatccaca gagaggcagc cctcgccgct tgttaagtag 1366381 cttttttcaa ctgaatggct gacgatctta ggattaaaca gagcatagct gtataattta 1366441 ccggaagcat cttccgcatg aacggcgatc attcgttttt tgatattaat ttgaggagct 1366501 gcgagtccta cgccagggcg cagcttgtat ttttcggcta attctggatt ttggctgttt 1366561 ttaacaaatt cgatcatgtc ggccagctgc tgtttttctg catcagttgg aggcagctca 1366621 acaggttcgg cagtctctct gagggctgga tggccgtcac gtacgatgtt ttccatagta 1366681 atcaagaaac ttcactccta aagcttaata tgtaaattat atcggatttc ttcacaaagg 1366741 tgcaacgaaa cgaatgacca gccgtatatg gctggtcaat ttcatgctgt gtggttagca 1366801 acagcctcca cctaaataag cagctccgac aatgattaac agaatgaata aaacaacgat 1366861 tagcgcaaag gtgcggccgt agccatatcc gcagccacca tatccgtaac caccataact 1366921 gcagcagcct ccgccgtaac catatccata catattacat aacctcctct tttaattacg 1366981 ccagagcctt tataagtagg catagcgtct aatataacct atgtaaaaac aaaaaagttg 1367041 tatggtcatc tgtcctgatt tttcactttt ttgatttaat ttcagtattg catttataca 1367101 gcacggctat tgccaaatgt ccccatggat tctatagtag aaattgtcaa gattggggga 1367161 tttaacgtga aagacgctat aaaacggcgg cctggaatca agatcggagc tttttgtgcc 1367221 atggcactga tattaacagg atgcatggga caggacccgg ttgattcact tcatcattca 1367281 ttagaaaaag ccgcggaatc ggaaaagccg tttcaagaag aacaaaacac actcaaagaa 1367341 ttagaggcca aagaaaatca gctttacgat agtgttatga agctcaatat ggatgattat 1367401 aaaaaaattg ttgctttatc taataaggcg cttgaaaatg tcagcaagcg cgaagaacac 1367461 ctaaagcttg aaaatgacag catgaaaaaa tcggaaacag aatttgagga agcaaaaacg 1367521 tcagcggaac atattaagga aaaagacata aaagaaaagg ccgatgccgc agcaaaccat 1367581 atggagaaaa gatatacatc atatggcact atgtataaag agtataaaaa agcgcttgag 1367641 cttaataaaa aactgtatat gcagctgaaa gacaaagatt tgacaagaga tgatctggat 1367701 cagcagatcg ataaagtcaa tgcttcttat gaaaagatcc ttaaatatag cggagaattt 1367761 aatgaacaaa ccgaaaaata taataaagcc cgggaagatt tatatgatgc tgcaggctat 1367821 cgtgtgaaaa agagctgact cgatcagctc tttttttgaa tgaaatgcga ttcggatttc 1367881 gttcaaaatt ttcatttcta ttgtagtaca gcatagtaag gtatactagt acagttttgg 1367941 gtgcggttgg catctgtttt tttgatgaaa atgtaaagcg aatacattta ttgaaaatca 1368001 gcgatgaaaa cgattgacgg ttcttcttta tttggtgtaa actaatccat gttaagcggt 1368061 gttgtattag ttttttacaa cttcgaaata atacagttca aagcagagtg taactatcct 1368121 acataaaagg ttttggcaaa ctggggatcg gctaaaatat aatacgactt actgctgata 1368181 ctttagggta ccctaagttt gtatgtataa aaggaatgca cgtctaatga ctgtttaaaa 1368241 gaaaggaaga ggtgacttag tatggctgca aaaacgaaaa aagctatcgt tgacagtaag 1368301 aagcaatttg atgccattaa aaagcagttc gaaacgttcc aaattttaaa tgaaaaggga 1368361 gaagtcgtga atgaagcggc gatgcctgat ttaactgatg atcaattaaa agagctaatg 1368421 cgccgcatgg tatttacgcg tgtgcttgac caacgctcta tctcattaaa ccgtcaagga 1368481 cgtctcggat tttacgctcc tactgcgggt caagaagctt ctcagattgc aacgcatttc 1368541 gcgcttgaaa aagaagactt tgttcttcct ggataccgtg atgtgcctca gttaatttgg 1368601 cacggccttc cattatatca agcgtttctt ttctctcgcg gacatttcag aggaaaccaa 1368661 atgcctgatg atgtgaatgc cctttctcca caaatcatta tcggtgctca atacattcaa 1368721 actgccggtg ttgcgctagg tcttaaaaaa cgcggtaaga aagctgtcgc aatcacttac 1368781 actggtgacg gcggagcttc tcaaggggac ttctacgaag gaattaactt tgccggagct 1368841 tataaagcac ctgcaatctt cgtggtgcaa aacaaccgtt acgcgatttc aactcctgtt 1368901 gaaaaacaat ctgcagctga aacaattgca caaaaagctg tagctgccgg tattgtcggc 1368961 gtacaagtag acggaatgga tccgcttgct gtatacgcag caactgctga agcacgcgag 1369021 cgcgcaatca acggcgaagg tccaacacta attgaaacac ttacattccg ttatggcccg 1369081 cacacaatgg ctggtgacga tcctactaaa tatcgtacaa aagaaatcga aaatgagtgg 1369141 gaacaaaaag atccgcttgt acgtttccgt gcgttccttg aaaacaaagg cttatggtct 1369201 gaagaagaag aagcaaaagt gattgaggat gcgaaagaag aaattaagca agcgatcaaa 1369261 aaagctgatg ctgaaccgaa gcaaaaagta actgatttaa tgaaaatcat gtacgaaaaa 1369321 atgcctcaca accttgagga gcaatttgaa atttatacac agaaggagtc gaagtaagcc 1369381 atggcgcaaa tgacaatgat tcaagcaatc acggatgcgt tacgcacaga actgaaaaat 1369441 gacgaaaatg tcttagtttt cggagaagac gttggtgtaa acggcggcgt attccgtgcg 1369501 acagaaggat tgcaaaaaga attcggtgaa gaccgtgtgt ttgacacgcc acttgctgaa 1369561 tctggtatcg gcggtcttgc ccttggttta ggcttaaacg gcttccgtcc ggtaatggaa 1369621 atccaattct tcggatttgt ttatgaagta atggattcag tttctggcca aatggctcgt 1369681 atgcgctacc gttctggcgg acgctggact tcacctgtaa caattcgttc tccattcggc 1369741 ggcggtgttc atactcctga acttcacgct gacagcttgg aaggtcttgt tgcacaacag 1369801 cctggtatca aagttgttat tccatcaact ccttacgatg ccaaaggact tttaatttct 1369861 gcgatcagag acaatgatcc tgttgtcttc ttagagcata tgaagcttta ccgttctttc 1369921 cgtcaggaag ttcctgaaga agaatacaca attgagcttg gaaaagctga cgtgaaacgt 1369981 gaaggtactg atctttcaat catcacttac ggcgcaatgg ttcatgaatc attaaaagct 1370041 gctgatgagc ttgaaaaaga cggcatttct gctgaagttg tcgaccttcg tacagtaagc 1370101 ccacttgata tcgatacaat tatcgcctct gtagaaaaaa caggacgcgc gattgtcgtt 1370161 caagaggcac aaaaacaagc cggtattgct gcaaacgtag tagcagaaat taatgaccgt 1370221 gcgatcctga gcttggaagc acctgtactt cgcgttgcag cgccagatac agtatttcct 1370281 ttctctcaag cggagagcgt atggcttcca aaccataaag acgttcttga aacagcaaga 1370341 aaagtgcttg aattttaatc aaactgcata atcgagaggg aagatgaacg ttttccctct 1370401 attatatatc tgttttcaat gcttacgatg taaactttaa aattgcttaa tcaaactagg 1370461 aggtcgagaa ctgtggcatt tgaatttaaa cttccagata tcggggaagg tatccacgaa 1370521 ggcgaaatcg taaaatggtt tgtcaagcct aacgacgagg tagacgaaga tgatgtactg 1370581 gctgaagtcc aaaatgataa agcagtagta gaaattcctt cacctgttaa aggaaaagta 1370641 ttagaattaa aagttgaaga gggaacggtt gcaactgttg gacaaacgat tattacgttt 1370701 gatgcacctg gttacgaaga tcttcaattt aaaggcagcg acgagtctga cgatgcgaaa 1370761 actgaagcac aagttcagtc aactgcagaa gctggacaag acgttgcgaa agaagagcaa 1370821 gctcaagagc ctgcaaaagc tactggcgca ggacagcagg atcaagctga agttgacccg 1370881 aacaaacgcg tgatcgctat gccttccgta cgtaaatatg cacgtgaaaa aggtgtagac 1370941 atccgtaagg ttactggttc aggcaacaac ggacgtgttg taaaagaaga tatcgacagc 1371001 tttgtaaacg gaggagcgca agaagctgca ccgcaagaaa cagctgcacc acaagaaaca 1371061 gctgctaaac cggctgctgc accagctcca gagggcgaat tcccagaaac acgcgaaaaa 1371121 atgagcggta tccgtaaagc aattgcaaaa gcgatggtta actctaaaca cactgctcct 1371181 cacgtaacgt taatggacga agtggacgta acaaaccttg ttgcacatcg taaacagttc 1371241 aaacaggttg ctgctgatca aggaatcaag ctgacttact tgccttacgt tgtaaaagct 1371301 cttacatctg cactgaaaaa attccctgtt ttaaacacgt caattgacga taaaacagat 1371361 gaagtcatcc aaaaacatta cttcaacatc ggtatcgctg ctgacactga aaaaggcttg 1371421 cttgtaccgg ttgtgaaaaa tgcagatcgt aaatctgtct ttgaaatttc tgatgaaatc 1371481 aatggccttg caacaaaagc tcgtgaaggc aagcttgctc cagctgaaat gaaaggcgca 1371541 tcttgcacaa ttacaaacat cggttctgcc ggcggacaat ggttcactcc ggttatcaac 1371601 catccagaag ttgcgattct tggtatcgga cgcattgcag aaaaagcgat tgttcgtgat 1371661 ggcgaaatcg tagcagctcc agtcttagct ctttctctca gcttcgacca ccgtatgatc 1371721 gacggagcaa ctgcgcaaaa tgcattaaat cacatcaagc gtttactgaa cgatccacaa 1371781 ttaattttaa tggaggcgta atgttatggt agtaggagat ttccctattg aaacagatac 1371841 tcttgtaatt ggtgcgggac ctggcggcta tgtagctgcc atccgcgctg cacagcttgg 1371901 acaaaaagta acagtcgttg aaaaagcaac tcttggaggc gtttgtctga acgttggatg 1371961 tatcccttca aaagcgctga tcaatgcagg tcaccgttat gagaatgcaa aacattctga 1372021 tgacatggga atcactgctg agaatgtaac agttgatttc acaaaagttc aagaatggaa 1372081 agcttctgtt gtcaacaagc ttactggcgg tgtagcaggt cttcttaaag gcaacaaagt 1372141 agatgttgta aaaggtgaag cttactttgt agacagcaat tcagttcgtg ttatggatga 1372201 gaactctgct caaacataca cgtttaaaaa cgcaatcatt gctactggtt ctcgtcctat 1372261 cgaattgcca aacttcaaat atagtgagcg tgtcctgaat tcaactggcg ctttggctct 1372321 taaagaaatt cctaaaaagc tcgttgttat cggcggcgga tacatcggaa ctgaacttgg 1372381 aactgcgtat gctaacttcg gtactgaact tgttattctt gaaggcggag atgaaattct 1372441 tcctggcttc gaaaaacaaa tgagttctct cgttacacgc agactgaaga aaaaaggcaa 1372501 cgttgaaatc catacaaacg cgatggctaa aggcgttgaa gaaagaccag acggcgtaac 1372561 agttactttc gaagtaaaag gcgaagaaaa aactgttgat gctgattacg tattgattac 1372621 agtaggacgc cgtccaaaca ctgatgagct tggtcttgag caagtcggta tcgaaatgac 1372681 ggaccgcggt atcgtgaaaa ctgacaaaca gtgccgcaca aacgtaccta acatttatgc 1372741 aatcggtgat atcatcgaag gaccgccgct tgctcataaa gcatcttacg aaggtaaaat 1372801 cgctgcagaa gctatcgctg gagagcctgc agaaatcgat taccttggta ttcctgcggt 1372861 tgttttctct gagcctgaac ttgcatcagt tggttacact gaagcacagg cgaaagaaga 1372921 aggtcttgac attgttgctg ctaaattccc atttgcagca aacggccgcg cgctttctct 1372981 taacgaaaca gacggcttca tgaagctgat cactcgtaaa gaggacggtc ttgtgatcgg 1373041 tgcgcaaatc gccggagcaa gtgcttctga tatgatttct gaattaagct tagcgattga 1373101 aggcggcatg actgctgaag atatcgcaat gacaattcac gctcacccaa cattgggcga 1373161 aatcacaatg gaagctgctg aagtggcaat cggaagtccg attcacatcg taaaataatt 1373221 ttcatatcaa aaacagcccc gctttgagcg agggctgttt ttttattttg acagcacatg 1373281 ctgtaatggt ttaatgatgt cttctttctt tttcacacat ccctcgattt tcaccacgac 1373341 atggcgctga tcaacaacca taagggtagg gacagtttca atctcatctt cccagccttc 1373401 ttttttatca tagaccttca ttttatctat ttgctcggga taatcttttt ctaaatcaag 1373461 cagtgcatcg taataaggcg cttcctggtc tatttggttc tcatcagaaa aaaacaggat 1373521 ttgtgtatga tgaatgttgt caatccggct ttttttcatc ggattgatgg tggaaagcgt 1373581 acagcccgat aaagcaaata ctattatcag catggggaat accgcgcgat atcgcatcta 1373641 tcttctcctc tgtataaaca gtagttaact agctttagtt tatcacgaga gacggcttaa 1373701 tctgcttctt gttacctaat tgttatataa ttgaaaccgt ttttaaagtg agattacata 1373761 ttatatcaat cgtttaaaat agcaacctgg ggtatattga attttttgct gcattcttgg 1373821 atgaaagttc aagaaaacgt gcaattacat tatgtgctgt ggcatatata tcgagtaaag 1373881 cttctgtatg aagaagatat tgtatgatgg aaaatggaaa aacaaggtga atatgatgat 1373941 atgaaataaa atgtgttata cagtttgttg ttgacatttt aaatgtgaca tattaatata 1374001 ataacaacaa aagaaattaa gcgttttcaa atttcaaaga aatggggaat aagagatggg 1374061 tacgattgtt tgccaagatt gcaacgaagc cattcattac tttgaagatg agaaagtgac 1374121 aacattatat ggaacttgct gcggacaatg tcaatgtcct gttgatgaag agtaaaaaaa 1374181 agcatgcggc ttaaagccgc atgcttttta ttttttattg aattgctttt tgttctttga 1374241 tgacccggat catatgtaaa gtcgagtcct caggtccttg aacagggagg cctgcgtcaa 1374301 ggtttttaaa aatgtagctg atgttttctt ctgtaataat ttctcctggg atgaagattg 1374361 gaataccagg cggatatacc atgacaaatt cagcaataat ccgtccggat gcttctttta 1374421 atgggatgac ttccgtattt gcatagaaag catcacgcgg agtcattgcc aataaaggta 1374481 tttctggaag cagaacctca gtttgctgat gtgttacatc ttgttctgac atttgctgtg 1374541 cgatctcagt taaagcctct acaagccggt ctgcatcatt ttggctgtca ccaggagtga 1374601 aaatacacaa aatattgtac agatcagaaa gctccacctc aatattaaag gattcacgaa 1374661 gccatttttc cacgtcatgt cctgtcaggc caagactttt cacagagata atcaattttg 1374721 tcggatcata gctgtaagct gctttcgacc caagaatctc agaaccgaca caataaatgc 1374781 cttcaatctg attgaggcga tctctcgtct gattggcaag cttgagtgtt tcctcagcaa 1374841 gctggcggcc ttctgttgca aggcgttttc tggcaacatc caaagaagcg agaagcaagt 1374901 aagaagttga cgtagttgtc agcatgctca ggatggattg cactctgtct ttagatacaa 1374961 ggccttctct catgtttaaa atagagcttt gtgtcagtga tccgcccagc ttgtgtacac 1375021 ttgtcgctgc tatgtccgct cctgcctgca tagccgatag cggcaattcg tcgtgaaaat 1375081 gaatgtgaac gccgtgtgct tcatccacaa gcactggcac atcaaacgaa tgagcgagtt 1375141 ctacgatgct ttttaagtcg gctgcaacac cgaaatatgt cgggttgatg acgagaagcc 1375201 cttttgcatc cggatgctcg gtaagcgccc gtttagcaga ttcaagtgta attccgtggg 1375261 agatgcccaa ttcattgtca atttcaggat gaataaaaat tggaaccgct ccggaaaata 1375321 caatagctgt cataattgat ttatgaacat ttcttggaat aataatttta tcaccaggtc 1375381 cgcaaacagc cattaccatt gtcataatgg cgccgcttgt tccttgaaca gaaaaaaatg 1375441 tatgatccgc tccaaatgct tcagcagcca gatcttgtgc ttgtttaata atgccttttg 1375501 gcgcgtgcag atcgtctaat ggttcaatat taatcaaatc tatgcttaac gcgttttcac 1375561 cgataaattg tctgaattct gggtccattc ctgccccttt tttatggccg ggaatgtgga 1375621 attgaacagg ctgtctgctt gcatgctttt tcagtcctgt gtataagggt gtttcatgtt 1375681 gcgacaattg ttttcccacc tttgtaatca tacctatgca taatagtgtg tattaaaatc 1375741 agtttctcaa ccgtttttta gacgtaaaac aaatgaatta tattatgaac ttgaaagaat 1375801 gtaaagaaca atttatgatc aaatgaagat gctttctctt aagggaagta aatctacaag 1375861 gagtgaagaa aatggagtat caatatccga tgaatgaaga ttggacaacc gaagaagcag 1375921 tggatgtgat tgcatttttc cagcaggttg agcttgcata tgaaaaaggg gcggatcgtg 1375981 aagaactgct taaagcttac cgccgtttca aggaaattgt accggggaag gccgaagaaa 1376041 aaaagctatg cggcgagttt gaggaacaaa gtacatattc tccttatcgc acggtcaaac 1376101 aggcgagaga atctgatcac gcgaagatta agatgtaaga aaaagagccg ggggatatcc 1376161 cggctctttt ttatgcttgt gttacttttt gggtgagacg gtacagaaaa gcaagctgtt 1376221 taaaggcatc gtcgatacgc tgaaggaatt cctggttatt catattcagc acttcttctt 1376281 tttggagctg gatgccgcat aacagctcgg ctttctttac agtctgcaaa cgctcaaaca 1376341 gtgtcttcag ctgttccttg tccatttcag actgtttatg tactcccggt tttgtgtgat 1376401 ctgcagacca aacgaagctg tcagggatat ttttcgtaat ggtttcttgg ttcacttcaa 1376461 gcaatttgcc gtattcttct ttgatagggg attcataaat aatcgcgaac catacaaaga 1376521 cgtggctttc ccataaacca atttggaaat gcggcagttt tttatagcct cttttgctgt 1376581 ttgcgaacgc cacccagctg tcagccgggg gattgacgga tcttcttgcg tgctttgcca 1376641 catgcggaaa catttcatct ccggttaaag ctgataaagt tggggcaaaa tgttcgccta 1376701 gagctgtaag cttcggacgg accgtctctt ttaatacttc catgcgcgcg tctaagcctt 1376761 ctattgtaaa tgtgttaaag tcttcttcag tgaaacgcat ttgtgtcatg attttcctcc 1376821 ttcatgctaa gtatacatat tttatcacag ttcatacgag cttcaaaaag attgagcgcg 1376881 tttgaagtaa ggagaaatgt ggtaataaac gagtaggtaa acacacaatt ttcagaatca 1376941 tgttgcgcgt aaatagaaca atcatacgat ataagaagta atcattgttg aatggcaaaa 1377001 tgggatgctt ttttacaaac aaatgatctc tggaaggggc gaaagacaat gaggcaagtt 1377061 gtaaaagagg gatttaagga agagaaaaac aatcgtgttg ctgtctggag actagaggtt 1377121 gattatgaat tggcaaccct atatgaagca atgcagaaag aaaatgaaga gcagattgaa 1377181 caaagcaaaa acaaacttga gcgacttaga aaagaatgga ttcgtcttaa cgggtaaaaa 1377241 agcgatagtg aaaacgaacc gcatgaatgg ttcgttttta cgtgagaagg gatatttttc 1377301 attttccttg ctttttcatt gccgttatca gtatcctata aaataaaagg tctacataga 1377361 agagaggtac gaacgaatga caaattggac ggaaatcgat gagattgcaa agaaatggat 1377421 aagagaagca ggcgcgagaa ttacacaatc catgcatgaa agcctgacaa ttgaaacgaa 1377481 atcaaatccg aatgatttag tcaccaatat tgacaaagaa accgaaaagt ttttcattga 1377541 tcgaattcaa gaaacatttc cgggacatcg gatactcggt gaagaggggc aaggagacaa 1377601 aatccactca cttgagggag tcgtatggat tattgatccg attgatggga cgatgaattt 1377661 tgtgcaccag caaagaaatt ttgcgatttc cattgggatt tttgaaaacg gtgaaggtaa 1377721 aatcggttta atttatgatg tggtgcacga tgagttgtat cacgcattta gcggcagagg 1377781 agcttatatg aatgaaacga agctggctcc attaaaagaa accgtcattg aagaagcgat 1377841 tcttgccatt aatgcaacat gggtaacgga aaacagaaga attgatcaaa gtgtgttagc 1377901 gccacttgtg aaaagagtca gaggcacacg ctcctacggt tctgccgctt tagagctggc 1377961 aaatgtcgcg gcaggaagaa tagatgctta catcacgatg cggcttgcgc catgggacta 1378021 cgcagccggc tgtgtgctgt taaatgaagt aggaggcacc tatacgacca ttgaaggaga 1378081 gccgtttacc tttttagaaa accacagtgt gctagccgga aacccatcta tacataaaac 1378141 gatatttgaa gagtatcttc atgctcggaa gtaggccatt tgagcaggat gatctcagct 1378201 tgttagaaaa gctcgcggag gctcatcctg tatggaaaga ggaggagttt ggagataaag 1378261 atgcagaaga ctatatcatt tcctactcca tgtacaacgg ttcatggctt gtatgggaaa 1378321 aagacggtat gcctgttgcc gtcagctacc atctcgagtg gtctccttca aacggtaagc 1378381 cgtggctcgg aacggtcctg attgacccgg ctgaagaaaa aaagggacat gcgaagatga 1378441 tcattgaaca gatcagcaaa ttgcttagag cgaaacataa agcgatgttt gcgggagttc 1378501 ccattgagcg cagggaatgg atactgtttt taagccaatg cggctttgaa cagctgaaaa 1378561 cggaaaaaga tgagaaaggc aaatcattta tgatcttggt gaagccttta gcagaagctg 1378621 ccgtatgata atggcagctt atttgctgca tgcgggttca ataaaaagcc tctcaaacat 1378681 tgagaggctt ctgatgattt gaaaattatt tttttaccgc atgaatataa tgaatcgttt 1378741 caaacgctga caaattgtct tttcgattac taaagaaaag gtcattgatg tcgtctggtg 1378801 atagatgttc atagatcagt aaaccagatg actctaacag atgttcaatc tcttgataag 1378861 tgaaacatga tttcatcggt tccccgcttg cggcagccat cttcaccata tgttcaactc 1378921 gattcgacgt cccttttgct gtaaaaagtg tttcgtccgc ataatcaaaa acaatagagc 1378981 ttccaggcgg gacatgagaa aataaattgc tgatcaagct tgcattttct tcccgtgtta 1379041 cataataaga cactccgaga aggctgaaga atgtttttgt gtttttaaat ccttcatcta 1379101 agagaggatc atacgaaaac gttttggtga aatccatagg aacaaaatga agatgacccg 1379161 gaattgtcag atttgcatcc ttcagcttat tttttttcaa ttgctgtgtg gccggatgat 1379221 caacctcgaa aacctgtaag ctgttttcta attctggatg ccgaaagcag aaagtatcca 1379281 gtcccgctcc aagaatgaca tactgttttg cccccaggat taattcgttg tgcaagactt 1379341 tttcacaata agaagcacgt gctaggggcg ttggagacag ctggatttgt gcaacccatt 1379401 ttaatatttt ttcaggatca ttttgaagac gttcggcgat ctctttgttg aaaaacgata 1379461 tttcttgaat catattttta ctgatgtcga taaactcttt ttcgttaatg agatcttttg 1379521 cgataaaatc atcaaaaata agaggtgtgt catatcggct gtgatatgca cgggcaaaag 1379581 ctgaaattag agacgttaag ctggactcat ttttcctcat gaaatgatcc tccacaaaaa 1379641 ataagattcc cctggccagg agaatcttat tatacataca aatatattaa tagtaaattt 1379701 tagcataaat aaattttttt gtcaatgttt ttgctcttaa ctggacgcgc gatccttcac 1379761 atagccacgt gacctgtagc agaattcgtc tatcaattat gtggactgaa tcattagctt 1379821 ttataaaatg cgcacttgcg gctgcatccc tctttatgca aatcaggagc ggttttctgt 1379881 ctcatggcag catcttttcg tcgtttcagc tgagagagaa atcaagatat gtaacaataa 1379941 aagcctgagg gatctcaggc ttttcctaat attacaatcc aacagcattc caggctgctt 1380001 caactttagc ggcatcagtt gagccgtaga ggtcacgggc agactgaatg agagctgcct 1380061 tggcatcttt gaacgtggaa gaaggcgtga ggtacgttgt taacgcacgg taatagattt 1380121 gctgtgattt agatacacca agttttgtga tggtgttgta agcggctttg tttggaattc 1380181 cgctgtttgt gtgtacaccg ccataatcgc cttcatctgt gtttggaagg tttcggtaat 1380241 tggcgtaatt gtcaggctgg ttgtattttg tagggttgga caggctgcga agagcaggct 1380301 ggctgaccgt aatgtcttca ccgatgtccc agtcttctgt atcgttaaaa tacccgaata 1380361 cgtcagagaa agactcgttt aatgcacctg gctgattttc ataaatcaag ttggctgttt 1380421 cttgggtgac gccatgtgtc atttcatgcg ctgtcacatc taatgagccg gaaagcggag 1380481 agaagaatga accgtcgcca tcaccgtaaa tcatctggtc tcctgtccat gcagcgttat 1380541 tgtattgagt gccgtagtga acggaagaaa cgattttact gcctttgtta tcatagctgt 1380601 ttcgtttaaa gtttgaataa aaataatcgt acactttacc gaggttatag tgtgcgtcaa 1380661 cggctgcccg ctgtgatgaa gatgtaaatg ttttcgttgt gcttgagaca agcgtgcccg 1380721 gaaggcggct ttgtctgttt tgcaaatcat atgtgatgat ttgggtgcct gttggttttg 1380781 aaagatctct tagaacatat tttccgcctt cataagagat gttcaaagga acagttgcgc 1380841 cctttagcgt tgttccgctt ccagtggcgg cggcatgttc tactttattt tgctgtttta 1380901 aaatgctgcc tgtttcggcg tcaactaaga cttcccagtt tgcaggttca ggctcgacat 1380961 agcgaatcgt cacgtcgtaa gcaagacgat agctgccgtc ttttgtttct atcgctttta 1381021 attcggcttt attgctgttt ttggccgctc cgttagaaac agcgtctggt gatttgccga 1381081 tagctttgaa agcgagtgcc agcgcttttt cagaagagac tttttggctg ttatctgttt 1381141 ttgcagcaga ttgattgtgt aattcaccat tgaccgcata gacattatcg gatttatcga 1381201 cgtgaacgat cacttgcgaa tctttaattg gcactccgtt aacgacaggc gcatatcgaa 1381261 agtgcttgta tccaagggca tcagtcgtgc tttcaacaag cttcagcctt ttggaagggt 1381321 cacctttaaa aatgttgctg ttctttttca aaaactgctt gacagccttg tcatttggtg 1381381 cagagagttc tgattgcgca atcgcgtttt tggagaggaa atttgtttga ttctctttaa 1381441 gctgatgacc ttcagcagcc tgaacacctg gcaggctgat tgataaactc ataaacgaag 1381501 cagcgacagc aacagacaat ttcttaccta aacccacaat aaatccccct ttttgaaaat 1381561 actgaaaact ttatattgtt atattaaact agcattctgg aatactcaac aaaaactaac 1381621 ataactagac aaaattgata gtattgtcct gtgtttgttt ttgttgaata atatcaagat 1381681 gagtcaagtg tcatgtggtg gttcattcaa gagttatgtt ttttacatat caaggggaag 1381741 atgagatatt tttgtttcat cttgaaactt tttgaaaagt ccgctgtcta accgaatgag 1381801 gccttaataa gaagtaaagg attgttgttc gtgttggagt tattcagtca ttatgtattg 1381861 catttcgaac gttattttat attaagcaga caaagcaccc tgctgattca atggtcaatt 1381921 gttgttctgg cgggcttata tcttttggtg catcatccca aaataaaccg gcagcgcaca 1381981 atgttcttgg cgggtgttat attgcggatt gtgctgctgg cgggagtgtc tgttgaactt 1382041 attcaccagg tgcaatcaac aaacttcacc agcgcttact taagagagga cggaaaagaa 1382101 ctgctgccgc tgctgcattt tttgttatac ggatatgtgc tgctgacggc ttttcactat 1382161 atgctgatgc cgcgtgatca tggcggaaag ggtaagtttt atacgttcga ccttgctgtt 1382221 gtcagtttgc cgatcgtaca aatgattttt agtttctttt cgtattggaa ggaatacccg 1382281 gatgggatgg agccgattgc attcgtgttt ctgtttttca tcatcactct tcccattgcg 1382341 ttgaatgtag tgtttttcaa gctgtattgg agaacggata agatcttact aggcttattt 1382401 tatacgctga ttatcggact gcttgtcttg ctgcttgcgc catatcccaa tcaaatctca 1382461 aaagattatg gtgcagtaat gccatatacg atttatttgg caatggcggg atttttgatg 1382521 agctatcatc tgttccaaaa gtcaggaaag gtttatgtgc gtgtgaataa gtgggtgacg 1382581 atggctgtca tggtgttttt tgtcctgctg ttaaatccga tatataacat aggaacggct 1382641 gctttcgctg tatcaaagcc agcaaatgtc catgattcat tcaattttgt cggggagcac 1382701 atttcatcag aaaaagcgga acagatacta aagtcatttt ttcctacgga tgaaacactt 1382761 tatttgcacg atacaaacat ggatgtgcat tatttctact catttgaaag caaaggttac 1382821 aaagctgagg tagatgaagt atcgcagcta attcgtaatt atgaatactt acaaaaagca 1382881 catgggaaaa agctaacgaa tcaggagtac aagcgaaagt ccatcgcttt ccttgagcga 1382941 cacggacgtg tgttacataa ggatcatatc gaaacaaagg tatctcaaga agacggccag 1383001 acagtcgtac gtatttacct gaaaaatcaa cttcataaaa aagatcatgc tgatgatggc 1383061 gcggtatttt attgggaaaa ggaaacctta atggggttta gtgaagatcc ttcgatttat 1383121 cagcttgact ctcttctgca tgttcatata acggaacaag acattcacga caaagtggaa 1383181 caaatgttta cagcgctgaa catatcaaaa cagccttatc agatcactga tattgaaagc 1383241 gacagcctgc ttggaagcat ggtgagagtt gaaacaaaag ttggaattgt tttggaattt 1383301 gagggcgaat caggttgttt acatagtctt tcgcttccga tgaaaaagaa tatctcaatg 1383361 gctaacagcc ggctgcagca tcagatatta tcgatcttcg atgctcgtgg atcagaaaag 1383421 aagaaaaaaa gcagtcaggg tgacatggtg atgtatactg attcttctaa aacatatgag 1383481 tttgttgaag ctcaaggtca gctaaacgtt tatgtataca gcgatacacc tgatcagtca 1383541 ttcccctata cgtatcgtaa tggaacattg gcttacgaaa aagtagcttc tctatatcag 1383601 gatgtcattt acaaaaagcg tatgcgtccg attatcgttc aaagagggga tgaacggcat 1383661 tatgcatggc tgatcattat tcagccgttt ggttcaaatc gccatgatgc ctatgtagtg 1383721 gatggagaaa cacaagaggt gaaaagtctt tatgaatcat aaagaaaaag agtctgtttt 1383781 tgtagactta tacgacctgt ataaagaagg agagctagag gatgaatcaa tggaatggat 1383841 gaaacagcat gaatccctat ttcaaaagaa tgcggaagac ttaaagagta aaacttgttt 1383901 aaagagaagt cccggtgctg aagaagaaag ccaaatcaga tatatgaaag tatacctgtc 1383961 ttccatgtat atctgtttca ttttattggc catttggatg acggtgtggt tttattttta 1384021 atgaagcata gggattccat tgaggacttg tatcggcagt attatcaaga aattttaaat 1384081 tatttattca gaaggactca tcatcttgaa acagccaagg acttagcgca ggacacgttt 1384141 gtaaaagctc ttaacggtct ggcttcgttt agggggcatt cttccatcag aacatggctc 1384201 tacaccattg cgcatcatac ctttatcaat tggtaccgaa gggatgtcaa ataccaattt 1384261 actgaaatca gcaaaaatga agggttaacg caaacaactt atgaccagcc tgaacagtat 1384321 ctgtcacgga cggtgaaaag cgaaacactg cggcaggagc tcctgaagtt aaaagatcag 1384381 catcaatccg ttttgatttt aagagaattc caagagcttt cttatgaaga aatcgctgag 1384441 atattaggat ggagtctttc taaggtgaat accacattgc accgggctag attagagcta 1384501 aagaaaaaca tgacgaaaag tagagaggag gagcggatat gacctgcttt ctagtaagag 1384561 acctgcttcc tctgtatctt gaaggtgatt gtaaaagaga aacggaacac gttatagaag 1384621 agcatttaaa aatgtgcagc agctgcagag acatgtatga cacgatggct gagccatttg 1384681 aattggaaag cgaacaggcc gttgaggagg cttatctgcc ggaagaagaa ctgcgtttta 1384741 aacagaggta ctatggatta ctgatcatga aagctgcctg ctggtttgga gcggcggttg 1384801 ccatgatgct gatcatcaaa ctgctgatat aaaaaaagcg cttgtccgat tccggcaagc 1384861 gcttttttac attaagcctg gggatgaatc atatcgtaaa tagcggcaag ctgttcttgt 1384921 gacagggcac tgaagagttt ttcataaacg tcagcttgca gtggcgttgc acctgcttgt 1384981 agcgctgcgt ctttatcata gctgtacaca tcatcttgta gcacaatggc tgcttgaaga 1385041 atgtgaatct tgagagaaac agcggagaaa aattgttcaa gtgcaagtgc ttctttttct 1385101 gtgaagccaa gttcaactgc tttttctgta tcaaatttgt aatttccatc ctcgagatac 1385161 acacattgtg aaacaatgct gaaaaattct gatgtcgatt cccagagtgt agcaattacc 1385221 tgagcctctt cttttgtcat tcctaactcg acagcttttt cgctgtcaaa ataatataca 1385281 ccgtcttgtt cgtatataca ttgatttaat atatcaatga atgtattgag atcttcgtta 1385341 gtgctcgcct gatgctggag ttgaacagca gtgttatcaa ccggtgtttt tgcgctggct 1385401 gcatcaggac cgaacgttaa tagagcagct gaggtcattg cggcagtcgt taacatagct 1385461 ttttttacaa atgttttctt catgtttctt ctctcccttt tatgaattgt gctacaaatt 1385521 ccattatagg gagtagtttc cggtggagga ataggcgcta tggtatttta tgtgtatcgt 1385581 tgccgaacta ctttttgaag gctgcacgtg tgatcgttag aacgattgtc tatgtatgaa 1385641 ggctgttttg catcttcctg actaagaaac aggggagata aggcttaaag aaatgaaaaa 1385701 caccgctttc tttgcggtgt tttttgatta caatgtcgcc ggcggggcaa tgcttttaat 1385761 caagcaagcc ttgttcgcgc attttctttt ttaatgtaaa tccgccgccc atgacagcgc 1385821 aaacaagtac aatgctggcg ataatgcctg cagggctttt ttcagcgata aagacgccga 1385881 tcagcataat gctgaaaacc gctgcaaatg caaataatag taaaagccaa ttcatttttt 1385941 tcataaattc catccccttt tacgtcttat attaagttta cagaaaaacg tgacgctttt 1386001 aaagaggatg tgtgatataa tatgaaagtt atctaatttt tttaggagat gaaaaagtga 1386061 aacttcgaaa tgatcttcgc aacatcgcga ttattgccca cgttgaccat gggaaaacga 1386121 ctctagtcga tcagctttta catcaggctg gtacgttccg tgccaacgaa caggttgctg 1386181 aacgcgcaat ggactctaat gatcttgaac gcgaacgcgg cattacaata ttggcgaaaa 1386241 atactgcgat taactataaa gatacacgta tcaatatttt ggacacccct ggacatgcag 1386301 actttggggg agaagtagaa cggattatga aaatggttga cggcgtagtg cttgtcgttg 1386361 acgcatatga aggctgtatg cctcaaactc gttttgttct gaaaaaagct cttgagcaaa 1386421 acctgaaccc tgttgttgtt gtaaacaaaa ttgaccgtga ctttgctcgt ccagaggaag 1386481 ttatcgatga agttctggat ctgttcattg agcttgatgc caatgaagag cagctcgagt 1386541 tcccagtggt atatgcttcc gcgattaatg gaacagcgag tcttgatccg aaacaacagg 1386601 atgaaaacat ggaagcttta tatgaaacca ttattaagca tgttccggca cctgttgata 1386661 atgcagagga gccgcttcaa ttccaagttg cccttcttga ctacaacgac tatgtaggcc 1386721 gtatcggaat cggacgcgta ttccgcggca caatgaaagt cggacagcag gtttctctta 1386781 tgaagcttga cggaacggca aagtcattcc gtgttacaaa gatttttggt ttccaaggct 1386841 taaagcgtgt ggaaattgaa gaagcaaaag cgggagacct cgttgcggtt tccgggatgg 1386901 aagatatcaa cgttggtgaa acggtatgtc ctgtagacca tcaagatccg cttccggtcc 1386961 ttcgcattga tgagccgaca cttcaaatga catttgtcgt gaataacagt ccgtttgcag 1387021 gccgtgaagg caaatatgta acggcccgca aaatcgaaga gcgtcttcaa tcacagcttc 1387081 agacggatgt gagcttgcgt gttgagccaa cagcttctcc tgatgcttgg gttgtttcag 1387141 gacgcggtga gctgcacttg tcaattttaa ttgaaaatat gcgtcgtgag ggctatgagc 1387201 ttcaagtgtc aaaacctgaa gttattatca aagaaatcga cggcgtacgc tgtgagcctg 1387261 ttgaacgtgt gcaaattgat gttcctgaag agcatactgg ctctgtaatg gaatcaatgg 1387321 gtgcccgcaa aggcgaaatg gttgatatga tcaacaacgg aaacggccaa gtccgtctca 1387381 tctttacagt tccttcccgc ggattgatcg gttactctac agaattccta tcattaacac 1387441 gcggattcgg tattttgaac catacgtttg acagctacca gccgatgcag gcaggccaag 1387501 tcggcggacg ccgtcaaggt gtacttgtgt caatggaaaa cggaaaagca acatcatacg 1387561 gtattcaagg aattgaagac cgcggtgtca tcttcgttga gccgggtact gaagtatacg 1387621 aaggaatgat cgttggagag cataaccgtg acaacgacct tgttgttaac gtcagcaaaa 1387681 tgaaacagca aacaaacgtc cgttctgcga caaaggatca gacaactaca attaaaaaag 1387741 cgcgcatcat gtctcttgag gagtctctag agtacttaaa cgaagatgaa tattgtgaag 1387801 taacacctga atccatccgt ttaagaaaga agatcctcaa taagaacgaa cgtgaaaaag 1387861 cagctaaaaa gaaaaaaaca gcaggattgt cttaatctcg tgcagaattt gaaaagatag 1387921 aacccgtacg tttacagggg agggaatctt tttgaatgac gtaagcgaac gcctgtcgtt 1387981 cttcgccgct ctatatcaag tagaccggca gcctgcggca ggcatgtggc tgctgtacgg 1388041 cacgattttt gtgttggccg ttattgtatt taagcttgga tttgctaaac ggcttcctgt 1388101 attaaaatct gcagtggtgt atgtattttt ggctttgggc tgcactgttt tgactttttt 1388161 aggggtgttt ttgcccgtgg cagaaggatt ggtcgtcgct gcgctgattt taatcattta 1388221 caaaatccgg ctgtatcagt cgaaaaaagg acagtctgca aaatcataaa agactcagct 1388281 gaaagctgag tcttttttgt gttctgtatg gttaagcggc cgctttattt tttgactttt 1388341 tcttttttct gctgtcccgg gtgaaaagta aattttcccg ttttcagccg ttcctctgtt 1388401 tttttggcaa tccgatcgtg gcattcctgg cacatatatg tatggatcgg gcggtttcga 1388461 agccgtttcg cgatcagggt atcatcatca attgtttcaa ttttatcgca aatagaacat 1388521 ttgaccctca tcatatcacc tctttcacta acatgtatta taccacggat cagaagctgt 1388581 ccaaaataag aaaaagctaa agcgcaaggc tatagcttag tcattgttgt tctttttcat 1388641 atgatgatca gattgatcgt tttgttcctt ctccatttcc tgttgctgtt ttctatttaa 1388701 ttggtcattt tgctgctttg tttgcggttc atcttcattg tcaatcacat cgttaggcac 1388761 ttcgggaagc actcggccga caattgcagc taattcatcc agtatacctg ttaccggatg 1388821 gccctcgctg atttctctgc tcatttcgcg aaggcggctg accgtatcgg gatcagcaat 1388881 gactactgcg ttggcgccat atcgatcatt ctttagcgcc tgagctacag aatatttaat 1388941 ggtttccact ttgcttctgt ccaaagtatc atcgacatca atcccaacaa cagcatagcc 1389001 tcccagcaca acggctgttg catccttgac gtcggggttt ttttcagcaa cgctgacaag 1389061 atgcttggca atatccgttc ttgttccatt gtcttttgtt tcttgagttg tgtcctttac 1389121 gtgaatcggt ttagtctcct gctgtcttgt tgattctttt tcaacattct ggccctgttt 1389181 tccttgttga taggcacaag cggacaggat aagtgtcagc tgtatgataa tgaaaagaat 1389241 tcgcacttgc gggttccctc cttaaaatgc tttcattaat tttattgttg aattaacctt 1389301 ctatctttat gcacaaaaac atatatttta gcaggcattc acctttttca tcaaaagaga 1389361 agcaggaaga actttgaccc ttatatcagg aggctgagac ttgagtaaaa tttatgtgtt 1389421 agatacgaat gtgttattac aggatcctaa cgcgatattt tcttttgaag aaaatgaggt 1389481 tgtcatccct gctgtcgttt tagaagaggt tgattcaaaa aaacggtata tggacgaagt 1389541 tgggaggaat gcaaggcacg tatctaagct aatcgatgcg ctaagacaaa agggcaggct 1389601 gcatgagcat gtaccgcttg acaccggcgg cacactgaga attgaactga atcatcgttc 1389661 gtttcaccag ctgcaagaga tctttattga aaagacgaac gataatcgca tattagccgt 1389721 tgcgaaaaac ttaagcctcg aggaagaaac caaggaaaat ggcaggccgg ttatccttgt 1389781 cagtaaggat gtactggtca gggttaaagc cgacgcaatc ggactgcttg ctgaagattt 1389841 cttgaatgac cgggttgtgg acaatgatga aatgtacagc ggctataaag atttatatat 1389901 cagccagcag ctgttcagct ctttttacgg gaaaaatcaa atttcagtaa acgatgtgaa 1389961 acagcatgcg ttttatccga atcagtttgc tttaatgaag gatgagctag gagggtcctc 1390021 ctcggcagtc ggaattgcag acaaaaccgg aacggtatta aaaagactcg tatttgatga 1390081 tgaacatata tggggaatca ggccgaaaaa tgtacagcag acaatggcat tagagctttt 1390141 gctgcgggaa gatattccgc ttgtcaccct gatcggcaaa gcgggaaccg gcaaaacgct 1390201 cttagctttg gcggcagggc tattacagac agaagacttg ggaatatata aaaagctggt 1390261 cgtcgcaagg ccgattgttc ctgttggcaa ggacatcggg tatttgccag gcgaaaaaga 1390321 ggaaaagcta aagccttgga tgcagccgat ttttgacaac ttagagtttc tgtttaatgc 1390381 gaaaaaacca ggggagcttg atgctatttt ggcgggaatt ggctcaattc aggtagaggc 1390441 gctgacttat atcagaggga gaagcattcc agatcaattt attatcattg atgaagcgca 1390501 aaatttgacc aggcatgagg tgaaaacgtt gctgacgaga gtcggtgagg gcagtaaaat 1390561 tgtcttaatg ggcgaccctg aacaaattga tcacccatat ttagacagtc tgaacaatgg 1390621 tttggcctat gtggttgagc ggtttaaagg acaacccatc tcaggcagcg tgaagctgtt 1390681 aaaaggtgag agatcaggtc tcgcccagct tgcagctgat ttgctgtaac acttaaatga 1390741 tttcgatctc ttttacatcg gtaatcggct gtttgtgatg aaccgggtct tcaaagtaaa 1390801 tatgcacggg gccgccttct tgaatcggct tgcctgcctc actgaaatgg acaatactgt 1390861 tcagagcggt ttccagagaa acggcggcct ttcccgaact tgtgacaaat acacattgtg 1390921 tcgcagagct gttcggctca gcatttttca ggacagtccc aagtctcatt gcgaaactgc 1390981 cgttcatcag tttttgcttc tcatattgct tttccgtctt taatgtaggc ggcgcgattc 1391041 gcccctctct gatgacgcgt tccggatcaa ggtcggattc atccccggct gattgtaaat 1391101 atgtgtcttg actgtcccct ttgcggtcaa acgaaaattt gcgatcatca aaaatccata 1391161 cgcttggatc aatggtaatt ggatatgtaa cattgccttt tacttggata acgctcatga 1391221 tatgaccccc ttctctcaaa attataaaag ttttcgcatg aattgtcact ttgtgtacaa 1391281 attatgtgta ttgaaatgct gagggaacga gggtgtttgc atggtatgcc agcataatga 1391341 tgagcttgaa gccttagtga aaaaggcgaa aaaagtaacg gacaaggggg aggtagccag 1391401 ctatattccc gccttggcaa aagctgataa acacgacctg tcagtggcga tttattattc 1391461 caataatgtt tgtctgtcag caggtgacgt agaaaaaaca tttacgcttc aaagtatatc 1391521 gaaagtcctt tcccttgctt tggtgttaat ggaatacggc aaagataagg tcttcagtta 1391581 tgttggacag gagccgaccg gtgatccgtt taattcaatt atcaagctcg aaacagtgaa 1391641 tccgagcaag ccgttaaacc ctatgattaa tgccggggca ttggtagtga caagtctgat 1391701 aaggggaaga acggtaaaag agagacttga ttatttgctt tcttttatca gaaggctgac 1391761 aaacaaccaa gagattacat actgccggga agtggctgaa tctgaataca gcacttcaat 1391821 gattaatcgg gcgatgtgtt attatatgaa gcagtacggc atttttgaag atgatgtaga 1391881 ggcagtaatg gatttatata cgaagcaatg cgcgattgag atgaacagct tggatttagc 1391941 gaaaatcgga tctgtattcg cattgaacgg cagacatcca gagactgggg agcaggtcat 1392001 ctcaaaagat gtcgctagaa tttgcaaaac gtttatggtg acgtgcggaa tgtacaatgc 1392061 aagcggggaa ttcgcaatta aggtcggaat tcctgcgaaa agcggcgtat ccggcgggat 1392121 aatgggcatt tcgccttacg atttcgggat cggcatattc ggccccgcat tagacgaaaa 1392181 agggaacagc attgcaggtg taaagctttt ggaaataatg tctgagatgt acaggctgag 1392241 tattttttaa tttatgtcat atgcttaaat cctcttgcat tttctgttga taccctttat 1392301 gataaataga agaattaggt actcgcctgg ggaacggagg gatacttttg gcttcagaga 1392361 tgatagttga ccatcggcaa aaagcttttg aactcttaaa agtggacgct gagaagattt 1392421 tgaagctgat ccgagtacaa atggataact taacgatgcc tcaatgtcct ctatatgaag 1392481 aggttttaga tactcaaatg ttcgggcttt cgagggaaat cgattttgct gtccgcctgg 1392541 gattggttga tgaaaaagac ggtaaagacc ttttatacac attggagcgc gaattgtctg 1392601 ctttgcatga cgcgtttaca gctaaataaa tgataaaact caaacttatt aacagtttgg 1392661 gtttttttat aaccgctatt tttctctcat ctcataaaag acggtctttt tttacacatt 1392721 ccttccgaat cgtatagaga ttcttcgtct cgtttgataa attgtagtaa aataaaaaag 1392781 ataaatacat aaaaaccata gataatggaa gttagaagca gggaagagga tgttatgtta 1392841 aaaaaaatgc taaaatctta tgattactca ctgatattcg caatcgtttt attatgcgga 1392901 ttcggtttag tgatggtata cagctcaagc atgattacgg ctgtctcccg gtatggagta 1392961 agcagtaatt ttttcttcat gcggcagctg tttgctttaa ttgcgggtgg cgctctattt 1393021 attctcatgg cgttgtttcc ttataaagca ctggcccatc aaaagtttca gaaggggata 1393081 ctgcttgtat ctgttcttgc gcttatctca ctgtttgttt tcgggcatgt tgccggaaac 1393141 gcgcagagct ggtttaaaat cggcggaatg agtattcagc cgggggagtt tgtgaaactg 1393201 gtcgtgattt tataccttgc agccgtatat gcaaaaaaac aaagttatat cgaccatctg 1393261 ttaacgggag tagcccctcc ggtagtcatg acgcttataa tttgtgggtt aattgccatg 1393321 cagccagatt tcggtacagc catgattata gggttaattg cgacgtgcat gatcttgtgc 1393381 tccggcttca gcggaaagac gctggtgagg cttgtgatac tgggcggaat tgttttcatt 1393441 ttagtcagcc ctattatcta tttgaatcag gacaaaattt taactgaagg ccgtttagcg 1393501 cgttttgaga gtcttgaaga cccatttaag tatgcaaatt catcaggttt gcaagtgatc 1393561 aattcttatt atgcgatcag ctcaggcggc attttcggcc tggggctcgg tgaaagtatc 1393621 caaaaatacg gatatctgcc tgaatcacac actgacttta ttatggctgt cattgctgaa 1393681 gagctcggca tttttggggt attgtttgtg attttcttat tgggttttgt cgtcataaaa 1393741 ggtttttata ttgccagaaa atgcgaggac ccgtttggaa gtcttctggc gatcggcatt 1393801 tcaagcatga ttgccatcca gtcgtttatt aaccttggcg gtgtcagcgg attaattccg 1393861 attacagggg ttacgctgcc atttatcagt tacgggggct cttctttggt gctgctgctg 1393921 gggagtatgg ggatattagc gaatatcagc atgtttgtga aatattcaga gaataagaaa 1393981 aagaaagagc ccttggcgcc gaagggaatg aaaaagaaac agctcaaaaa aactgtttat 1394041 ctgtaaaaaa caagtgtgta caggggaagg atattccgct atgatagatt atattccatt 1394101 cgggtaaggg ggagaaaagt ttgtctcagc aatcgataca aaaagtatta gtagcaaaca 1394161 ggggagaaat tgcaatccga atattccggg cgtgtaccga gttgaatatt cgtacagttg 1394221 cggtctattc aaaagaagat tccggttcct accatcggta caaagcggat gaagcatact 1394281 tggtcggtga agggaaaaaa ccgattgatg cttacctgga tattgaaggt atcattgata 1394341 ttgcgaaaag aaacaaagtc gatgcaattc atccgggata cggtttctta tctgaaaata 1394401 ttcattttgc gagacgatgt gaagaagaag gcatcgtatt catagggcca aaatccgagc 1394461 atctcgatat gtttggtgac aaggtaaaag cgcgtgagca ggcagaaaaa gcgggaatcc 1394521 ccgtgattcc gggaagcgac ggtcctgccg aaacgcttga agccgtcgaa caatttggac 1394581 aagctaacgg ttatccgatc atcattaaag cctcgcttgg cggcggcggc cgcggtatgc 1394641 ggattgtcag atctgaaagt gaagttaaag aagcatatga gcgtgctaaa tcagaggcga 1394701 aagcagcctt tggcaatgat gaagtttatg tagaaaaatt aattgagaat ccgaaacata 1394761 ttgaggttca ggtcattgga gacaagcagg gcaatgtcgt ccatcttttt gagagggatt 1394821 gctccgttca aagacgccat caaaaagtca ttgaagtggc gccgagtgtc tcgctgtcac 1394881 ctgaattaag ggaccaaatt tgtgaggctg cagttgcgct tgccaaaaat gtaaactata 1394941 taaatgcggg gacggtcgaa ttccttgttg caaacaacga gttctacttt attgaagtaa 1395001 atcctcgcgt acaagttgaa cacacgataa cagaaatgat tactggtgtc gatattgttc 1395061 aaactcagat ccttgttgcc caagggcaca gccttcacag caaaaaagta aatattcctg 1395121 agcaaaagga catttttaca atcggctatg ccattcagtc acgggttacg actgaggatc 1395181 cgcaaaatga tttcatgcct gatacaggaa aaatcatggc ttaccgctca ggcggcggtt 1395241 ttggtgtccg tcttgatacc ggaaacagct tccagggcgc cgtgatcaca ccatactatg 1395301 attcacttct cgttaagctt tcaacttggg ctttaacgtt tgaacaggca gctgccaaaa 1395361 tggtgcgaaa ccttcaggag tttagaatca gaggcataaa aacgaacatt ccgttccttg 1395421 agaacgttgc aaagcatgag aagttcctga cagggcaata tgatacatct ttcattgata 1395481 caacgcctga attatttaat ttccctaaac aaaaagaccg cggaacgaaa atgctcactt 1395541 acatcggcaa tgtgacagtg aacggcttcc ctggaatcgg gaaaaaagaa aaaccggcgt 1395601 ttgacaaacc gttaggcgta aaggtagacg ttgatcagca gcctgccaga ggaacaaagc 1395661 aaattctcga tgaaaaaggt gcagaagggc ttgcaaattg ggttaaggag cagaaatctg 1395721 tccttttaac tgatacgaca ttcagggatg cccaccaatc gttattggca actagaatca 1395781 gatcgcatga tttgaaaaaa atcgcaaatc cgacggctgc gttatggcct gaactattca 1395841 gtatggaaat gtggggaggc gcgaccttcg atgtagccta ccgattcctg aaagaagatc 1395901 cgtggaaacg tttggaagat cttcgcaaag aagtgccgaa taccttattc cagatgttgc 1395961 ttcgctcatc aaatgcggtc ggctatacga attatccgga caatgtgatt aaagaatttg 1396021 tgaagcaatc agctcaatcc ggtattgatg tgtttcgtat tttcgacagc ttaaactggg 1396081 taaaagggat gacgttagcc attgatgctg ttagggatac cggcaaagtg gcagaagctg 1396141 cgatttgtta tacgggagat atccttgaca agaaccggac gaagtacgac cttgcatatt 1396201 atacatcgat ggcgaaggag cttgaggcgg ccggagccca tattctcggg attaaagata 1396261 tggcagggct gttaaaaccg caggctgcat atgagctcgt ttctgcgttg aaagaaacga 1396321 tcgacattcc ggttcacctt catacgcatg atacgagcgg aaacggtatt tatatgtatg 1396381 cgaaagctgt tgaagccggc gttgatatca tagacgtggc ggtcagctca atggcgggat 1396441 taacgtcaca gcctagcgcg agcggatttt atcatgcgat ggaaggcaac gaccgccgtc 1396501 cggaaatgaa tgtccaaggc gttgaattgc tgtcccaata ttgggagtcg gtgcgtaaat 1396561 attatagtga atttgaaagc ggaatgaagt ctccgcatac tgaaatttat gaacacgaaa 1396621 tgccaggggg ccaatacagc aacctgcagc agcaagccaa gggagtaggc cttggcgacc 1396681 gctggaacga agtcaaggaa atgtacagac gcgtgaacga tatgttcggt gacatcgtca 1396741 aggtaacgcc ttcctcaaaa gtagtcggag atatggcact ctacatggtg caaaacaatc 1396801 tgactgaaaa agacgtttac gaaaaaggtg aatctttaga tttccctgat tctgtcgtgg 1396861 agctttttaa aggaaatatc ggccagcctc atggcggatt cccagaaaaa ctgcaaaagc 1396921 tgatcttaaa agggcaggag ccgattacag tcagaccggg cgaactgctt gagccggtgt 1396981 catttgaagc gatcaaacag gaatttaaag agcagcataa cttggaaatt tcagatcagg 1397041 atgctgtggc atatgccctt tatcctaaag tcttcactga ttatgtgaaa acgacagaaa 1397101 gctatggaga catctcggta ttagatacac cgacattctt ctacggtatg acattaggtg 1397161 aagagataga agttgaaatt gagcgcggca aaacgctgat cgttaagctg atttcaatcg 1397221 gtgagcctca gcctgatgcc acccgcgtcg tttatttcga actcaacggg cagccgcgtg 1397281 aagtagtcat taaagatgaa agcattaagt cttccgttca ggaaaggctg aaagcagacc 1397341 ggacaaatcc aagccacatc gcagcttcca tgcctggaac agttattaag gtattggctg 1397401 aagcaggcac aaaagtcaat aaaggtgatc atttgatgat taatgaagcg atgaaaatgg 1397461 aaacaacggt tcaggcgcct ttctcaggaa caatcaagca ggttcatgtg aaaaatggtg 1397521 agccgatcca aacgggagat ctgctccttg aaattgaaaa agcataaaaa acaaagagtg 1397581 tatatcaatg atatacactc ttgtttttta tatagaaaat gtggagtgaa acagatggtt 1397641 agaagagata taaggggact tcagagatta tagagtactg tcacaagccc aaaataaaaa 1397701 gaggcttata cagccaatat tttagatgct ttgtagtatg ccgtgcatat ttctttaagc 1397761 actatctgat ttaaaaggct ttaatactta tgttcgcgag ctatagatcc atatgaaatt 1397821 tctataatca cgatgagaaa ggggacagac cgaagtgagc cgctcactga tcatcaagtt 1397881 cggcgaaggc tggcgattga aacgcataaa gcgccaaaaa acaagacata aaaaagacca 1397941 aagccgccta aggctttggt cttgagtcct tatgattgcc tggattcata acggaaacga 1398001 gcaatcaata ataagaagta gcatagaacg ccaaacagac aggcaataaa gaacgagtgg 1398061 gcaagtgcaa agcccagagc cagttcagag tatacgatca taataccgga cagtgcctgt 1398121 aatgtaatga aaataagaca tgagatccat ccccaaaaga tctgtttttg atctttatag 1398181 gaagtaatag catgaacagc ggcaacaata atccatacaa ataaaagtaa ggctgctgct 1398241 ctgtggccca tttgcaccca ttcatggaat tgggtcggaa gtccattgtt cagcgggctg 1398301 cacagcggca cattaggaca tgccagactt gattcagtgt gtcttacata tgcgcctgta 1398361 tacacaacga tataggaata tattaaaatt cctatcatgt gaaattgcat ctttttgccg 1398421 atttgaagcg gcttaaccag tgttctgact gatttatcag cttcaaatat gagcaatgtt 1398481 aaaataagca ctgaagcaaa agaaattaat gagatgccga agtgaagcgc cataatcagc 1398541 gcgttcgaac cgaatacgac agccaatgcg ccaagcaatg cctgaagaaa taaaaagata 1398601 attgacatga tcgcgagaaa cgttgtttca cgaaaaatcg gcgtgatttt tctccatgac 1398661 caaaacgcaa ggcttagcac aaggataata gagattccgc ttgcgaatcg gtggctccat 1398721 tcaataattg aagccggatt cagttcaggg aaaaaacggc cgtgacacag cggccactgt 1398781 ctgccgcatc cttggccgga acctgttttt gtaacgaggg cacccccgat taaaacaatt 1398841 agcatgacaa atgtcgtcag aacaccgaga gcttttaatg ctttattcat acaatattca 1398901 ccttcttaac atactgctgc aattttatat acgttccaag tgtaagcgaa tatgtgtttt 1398961 gtggcaattc ccagagcctt ttgttcacaa aaatataata gaatgacggc ttctggaaaa 1399021 tgtacacttg attattcatg ccgggtctga tagaaataag gtaaacgcaa tgccgatttg 1399081 gagattgcct tcatctttgg taaaattcat aaaaagttca caaataaatt cctgtttgtc 1399141 gtttaatatt taataggatg tttttttaca agatgttatc ttgtatgata gagttgcagg 1399201 ttattttatt ctcctgcgtt aggtttgtaa gggaggttta cgttatggct aactccagaa 1399261 tcttaaatga tacagctata gacggacaaa ttgaagaaac aacggcatgg aaagattttc 1399321 tgtcccttat taaaataggg atcgtcaatt ctaacctcat cacgactttc actggaatgt 1399381 ggcttgcact gcatatatcc ggtttaagtt ttttaggcaa tataaacacc gttcttctta 1399441 cgttaatcgg gtcttcactg attattgcgg gctcctgcgc gatcaataac tggtatgacc 1399501 gggacattga ccatcttatg gagcgtacga aagtaagacc gacggttacg ggtaaaattc 1399561 agccgagtca ggcgttatgg tctggaattt tgctggttgc tttaggattg atcatgctgc 1399621 tgatgacaac tgtcatggct gctgttatcg gttttatcgg agtctttacg tatgttgtat 1399681 tgtacacaat gtggacgaaa cgccgctata cgattaacac agtagtagga agcgtttccg 1399741 gtgcagtgcc gccgcttatt ggatggacgg cagtggaagg gaatatcggt gtcgtagcat 1399801 gggtgttatt catgatttta tttatttggc agattcctca cttcttagca ttggctatta 1399861 agaaaactga ggattacaga gctgcaaata ttccgatgct tcctgtcgta tacggatttg 1399921 aagtgacaaa aagacaaatt attgtgtggg ttgcgtgcct gatgccgctt ccgtttttcc 1399981 ttggtagcct gggtcttccg attgtcattc tcggcttgct gttaaatatc ggctggctga 1400041 ttcttggctt aatgggattc cgctccaaga atatcatgaa gtgggcaacg cagatgttcg 1400101 tttactcgct taactacatg acaatctatt tcgttgccat ggttgtcttg acgcttttct 1400161 aaaaaataga tatgatgctt gttttatcgc ttcaaaataa acgatgacaa ctagtaaatg 1400221 ccgccttgac ctcttgttta atcaggcggc tttactttta tacatagatg gcattttgag 1400281 taaaaaaact cataatttaa gagaagagga aatgtaagtg ctttattggt gataggttgg 1400341 atggcgatag atttcgatcc gctttccgcc tttgtattga ccagaaaagg ggttgggtga 1400401 aatggtaaag cattggcgtc ttattttatt attagcctta gtgccgcttc tattaagcgg 1400461 atgtggaaaa ccttttttat ccacgctcaa gcctgctggc gaggtggctg ataaacagta 1400521 tgacctgaca gtgctcagca cattgattat ggtggttgtt gttgcagtag tatctgttat 1400581 cttcttttat gtgattgtga gattcagaag atcacgggtc ggtgagaaca cgataccgaa 1400641 acaggtagag gggaataaat ttttagaaat cacatggacc gtgatcccga ttttgctgct 1400701 cattattctt gtgattcctg ttgtattata tacgctggag ctagcggaca catcaccaat 1400761 ggataaaaaa ggccgcaaag ctgaggatgc tcttgtagtc aatgttaggg caaatttata 1400821 ctggtgggag tttgagtacc ctgattacgg cattatcaca agccaggagc tgattgtacc 1400881 gacagatcag cgtgtatatt ttaatttaaa agcctctgat gtaaaacatt ccttctggat 1400941 tccttcagtt ggaggaaaac ttgatacgaa tacggataat gaaaataagt tcttcctgac 1401001 atttgattca aaacgaagca aagaggcagg agatatgttt tttgggaagt gtgcagagct 1401061 ttgcggccct tcacatgcgc tgatggattt taaggtgaag acgatgtctg caaaagaatt 1401121 tcagggctgg acaaaagaaa tgaagaacta taagtctaca gcagagagcg atttggctaa 1401181 gcagggtgaa gaactgttta aagagaaaaa ctgcctgagc tgccatgcgg tagagccgaa 1401241 tgataagcgt gcagaagccg ctagaacggc acctaacttg gcgaccttcg gtgaaaggac 1401301 aaaagtggca ggggtgaaag aggccaacaa agaaaatgtg aaggcttggc tgaaggaccc 1401361 tgacagcata aagccgggga acaaaatgac aggcacatat ccaaagctct cagacagcga 1401421 aacaaatgcg ctttatgaat acttaaaagg cttaaaagcg gaaagcaagt agggaagaaa 1401481 gggagatatt gggggaggtc acatatgttg aatgcgctta cagaaaagcg gacgcgcgga 1401541 tctatgcttt gggattattt gacgacggtg gaccataaaa aaatcgcaat tctttattta 1401601 gtggcagggg gattcttctt tcttgtcggg ggaattgaag cgatgtttat cagaattcag 1401661 cttgcaaagc cggaaaatgc gtttctcagt gctcaagcgt acaatgaagt aatgactatg 1401721 cacggaacga cgatgatctt tctggctgcg atgccgctct tatttgcctt gatgaatgcg 1401781 gttgtgcctt tgcagatcgg ggctcgggac gtttcgtttc catttttaaa cgcgcttggt 1401841 ttttggctct tctttttcgg gggcattttc ttaaatctaa gctggttttt gggcggagcg 1401901 ccagatgcgg gctggacatc atatgcctca ctttcgcttc attctaaagg gcacggcata 1401961 gactttttcg tcctcggact ccaaatatcg gggctcggga cgctgatagc cgggattaac 1402021 tttttggcca cgattatcaa catgagggct ccgggcatga cgtatatgag gctgcctttg 1402081 tttacatgga cgacatttgt ggcctcggca ttgattttgt tcgcgtttcc gccgcttacg 1402141 gttggattgg ctctcatgat gctggatcgg ctgttcggaa ccaatttctt taatccggag 1402201 cttggcggaa atacggtcat ttgggaacat ttattttgga tcttcggcca cccggaggtt 1402261 tatatcctaa ttttgcctgc attcggtatt ttttctgagg tcatccctgt gttcgccaga 1402321 aagcgtttgt ttggctattc ttcaatggtt tttgcaatcg tgctcattgg ctttctgggc 1402381 tttatggttt gggtgcacca catgttcacg actggtctcg gcccgattgc aaatgcgatt 1402441 tttgcggttg caacaatggc tatcgcgatt ccgaccggga ttaagatttt taactggctg 1402501 ttgacgattt ggggaggaaa tgtgaagtat acaaccgcta tgctgtatgc tgtctcattt 1402561 attccatcct ttgtgctcgg cggtgtgacg ggagtcatgc tggcagctgc tgcggctgat 1402621 tatcagtttc atgatacgta ttttgtggtt gcgcacttcc actacgtcat tattggcggc 1402681 gttgtattcg gccttttagc cggtgttcat ttctggtggc cgaaaatgtt cggtaaaatt 1402741 ctgcatgaaa cgatggggaa aatttcattt gtattgtttt ttatcggctt tcacctcacg 1402801 tttttcattc agcattttgt cggcttaatg gggatgccgc gccgggttta tacgtttttg 1402861 ccaggacagg gtctggaaac cggcaacttg atcagtacaa tcggggcgtt ttttatggcg 1402921 gcagctgtta ttcttctgct ggtcaatgtc atatggacat cggtaaaagg tgaatatgta 1402981 ggtgctgatc catggcatga cggacgtacg ctggaatgga ccgtttcttc accgccgccg 1403041 gagtataact ttaaacagct tccttttgtc agaggacttg atccgctttg gatcgagaag 1403101 caggcagggc acaaatcaat gacgccggcg gaaccggttg atgatattca tatgccaaac 1403161 ggctcaatcc tgccgctcat catttccttc ggcctttttg tcgcagcgtt cgggctgctg 1403221 tacagaagtg attacgcttg gggcctgccg gtgatcttta tcgggctcgg catcacattt 1403281 attacgatgc tgcttcgttc agtaattgat gatcacggct atcatattca taaagaggaa 1403341 ctgccgaacg atgataaagg ggtgaaggca taatgcaagt tcaagaaaaa ttcaccgcag 1403401 aaacctttcc agcttctcct gaaaaagtaa ccctggaagg gaaaaataaa tttttaggct 1403461 tttggctttt tcttggcgga gagactgttc tgtttgcgtc tctcttcgcc acgtttcttg 1403521 cgcttcggaa ttcaaatgcc ggtgatccgc ctacgacgga aatgttcgat gtgacacttg 1403581 tattcattgc cacaatgctt ctattaacga gcagtttaac gagtgtgtac gcgatgtacc 1403641 acatgaagaa cttttccttc ggcaagatgc agctttggct gggaattacg attttattgg 1403701 gggcgggctt tttaggactg gaaatctatg agttcaagca ttacacccat gaatttggct 1403761 ttaccatcac aagctctgcc cttggttctg cgttttacac gcttgtcggt acacacggcg 1403821 cccacgtggc atttgggctt atgtggatca gcacgcttat gatccgcaat gccaagagag 1403881 ggctgaatct gtatacggcg cctaagtttt acgttgccag cctttattgg cactttattg 1403941 atgtcgtgtg ggtcttcatc tttaccgttg tatatttaat ggggatggtg ggataaacat 1404001 ggtcgataaa aaaagcagag ggcatatcaa tagcgacctt gaatttaaga aaaaaaagca 1404061 tgcccgggag atgaaatatc aagtcctgtc ttttggttta atgatcggtc ttacgattgt 1404121 tgcatttctg actgtggcca cggacggtgt cggcagctgg tttacgattc ctttcattat 1404181 tttgctagct gcaattcaag tcatttttca gctgtattat ttcatgcata tgaatcagaa 1404241 agggcatgag gcgccggcac tgtttttgta ttcaggggtg tttgtcgcgt ttatcactgt 1404301 gcttgcgttt gtgacaatta tatggtggta atttgaacag ccgccggagg tgaagaaatg 1404361 aatcagttgg agatatttgg gtttcgcgcg atgtggagcc cttatctttt ttgtatcctg 1404421 ttaggcatta cggcgcttta tctctatttt tacaggcgaa tgtcttcaaa gccgaatcga 1404481 ataactggta aagagatggt gtgctttctg tcggcgatgc tgtttttata tgcagccgag 1404541 ggaagcccgg ttgatctgct cggacatatt atgttcagtg cgcatatggt gcagatggcc 1404601 gtcctgtatt tggttgtccc gccgctgtta atcgcgggga ttcctgcatg gctctgggaa 1404661 aaaatcattt tcaggccttc aatcaaaccg gttttttcct tttttacgac gcctttaatt 1404721 gctttgcttt tgtttaacgg cattttttct ttatatcatg taccgcttat atttgatact 1404781 gtcaaaacag atccgtttta ccatacatta atcacttggc ttatctttgt gcttgcgttc 1404841 ttcatgtggt ggccgcttgt tcataaggtt gagcgtctac ggcagctcag cggcttgatg 1404901 aagctgggtt atattatggc ggacggtatg ctgctcacac ctgcttgcgc cttgatcatg 1404961 ttcagcggtg caccgttata cgccacctat acagatccgg ctttatgggc tgaggcaatg 1405021 aggctttgcg tgccagcgga tatgatgggg caggtcccat taacagggcc agagatgttg 1405081 aatacactgc ctttgttaga ggatcagcag ctcggagcag tcatgatgaa aatcattcag 1405141 gaaattgtgt acggtacttt tttggccgtt atttttttcc aatgggtgaa gaaagaaagg 1405201 gaaaaggacg ggcaggagga gccgccgtat attcagcaga cgatatcata aaaggtacag 1405261 cgaaatatgc tgtacctttt cgttacattt gaactgtttt taacatgttg gctatgtcct 1405321 gaatcagtgc cttgcttttt gtcacaacct gtacgggaaa ctcttccgtt tctccatatt 1405381 ctactccatg agggtagtaa tgctttccta ggagagggga cattaattga atcacggcgc 1405441 gcccgcttcc gacatcgcct tctgccgcaa taccttgtat ccgcaggtaa aacgtaccct 1405501 caatcgtcga aaacttcttg tcataggtga ctctctcgta atcccattga cccgctctga 1405561 taagaccttt gctttccatt aagtcgtcta gccagctgag ctcagcctta accccttcaa 1405621 gtccgctttc agtaaacttc aacactgacc cctccttata aaaattacct ttcctgacaa 1405681 tcatagtatg aaagcgttaa actttcaatg aatcttcttc ttttgaaagt atgcaaaaat 1405741 taaattttga cgacaatagc actagactaa aggaggttaa acggatgaca aaaataaaag 1405801 atctgatgac agccgacttg caatattgca cggtattaga taatgtatat gaagctgcag 1405861 taaagatgaa ggacgcaaat gtaggagcga taccggtagt tgatgaggac ggggaaacat 1405921 tggtcggcat cgtaaccgac cgcgatctcg tattaagagg aatcgccatc aaaaaaccga 1405981 actcgcaaaa aatcactgac gcgatgactg aaaaacctgt cagtgtggag gaagatgctt 1406041 cagtcgatga ggttcttcat ttgatggcat cgcatcagct cagaaggata ccagttacaa 1406101 aaaataaaaa actgactgga attgtcacgc ttggtgatct ttctttatct gagcaaacga 1406161 atgaacgtgc cggcagcgcc ttatcggata tttccgaagg ggataataga gaagaaggct 1406221 tttttcatta acacataaat ctttgacatg ttaaataggc tgtattgtaa tgggatgtaa 1406281 acaagagatt gtgaatcgcc acgggggtga tagattgaaa aatatattga gagcaatggt 1406341 tatccttttg attatctgcg gaacctatgt tctgtttatt caatatggat ctgttcctga 1406401 aaagaaatca aatgacagcg agcctcaggt gtcgaatgag gaagcgcaaa gcggcaaacg 1406461 aatacatatg ccgacttcag ggttattgtc cttcatgggc aagcacgccg atgaagtaac 1406521 gaaaaagctt ggggaacctg aacgtattga cccttcggct tatgattacg attggtgggt 1406581 atacaatcaa ggtaaggatc aatatatcca aatcggggta ttaaacaata aagtggtcac 1406641 attattcgcg tcgggtaatg atattaacgc caagcctttc aaaattggag aatcaactgg 1406701 cgaagtattc aagaccaccc aggtggcacc atttgtgaat gtagagtata aaggaaattc 1406761 ctatcggttt gaattttctg aagaagatat caatacaaga ccgactgtaa aggtaggaaa 1406821 gatgtatgtc cagctgtata tggacaaatt tgaggggaag ctatccagca tcagggcgtt 1406881 tgatgcgcag acctttgtaa agcaaagacc ttatgaggta gtgtaccgcg gggaattaat 1406941 taaaccgaaa gccgtttcag atgagaaatg gaaaaagatc caaacaacga gcgaaaagca 1407001 aatccttgat ttgacgaatg tcatacgcgt taaacatgga cttgcgaagc ttgagtggga 1407061 tcagccaacg gcggaagtgg catttgggca tagtgaggat atgaaggaaa ataattattt 1407121 ctcccatgtc tctaaaaaat acggctcgct gaaagaccgc ttagaagaag ggcatgttga 1407181 ttttcagcaa gcgggagaaa atatcgcata caattatgtg gacggtccgg ctgctgtaga 1407241 aggctggctg aatagcgaag gccatcgaaa agcgcttctg aattcagatt atacgcatct 1407301 tggtgtcgga gtagaccgga aatattacac ccaaaacttt attaagcgat ggtaatgaaa 1407361 gccgcggacg aatggttccc ggctttttct atttccatac aagctggtct gaatgaatgt 1407421 gctgatagct tacagataag gccgtttccc atcccttcag tcaggctttt tcaccagtgt 1407481 atagggatat cgctaaaaat tcatttggga atgaatatag gcgaacacaa tgcccgacaa 1407541 aacgatacat tgtagtaggt aacgattttc ggagggggtg aggattgtgg cgaatcaaca 1407601 tgccaatcat tcaatcaatg actttaaaca attcgtcaaa aagcatccca agctgataaa 1407661 agaagtgcgc aaagaacaaa gaagctggca ggacgtatat gaaaattggg tcctcttcgg 1407721 ggagagcgac ccgatttggg atccatatcg ggaaccggaa gaagcttctg aagctgtgcc 1407781 tgaaacaccg caaaaaaatg attttgtctc gaaaatggtg acagcggtga aaaagatgga 1407841 tgtcaatcaa atgaacgaac aaatcaataa aatgagccag tcgatctcat cgttgcaaag 1407901 ccttcttaat acattttccg gaagcggaca gaagcattct cagccaggct ctggacagca 1407961 tcctttttct tttcgaaagg attaaaaaag gggagctcat atgcgcaaag aggttcagga 1408021 atatatttta gcaaacgaag aacggaaacg attcatcaga gaacagccga tatggtaccg 1408081 caggctttca agaaaaccgg atgatctgtc ctcctttcag cttgaaatga tgaattttta 1408141 tgaaaaaacc attccgcatc gggtgaatca gtttacgaac gggattcaaa tggcgcaaat 1408201 gatgatgcaa atgtttcaag cgatgcggac aaaagattaa aaggccccga agaagggtct 1408261 tttttcatgc ggtcataagg ttttgttggc ggctgcggtt aagcattttc caattggctg 1408321 gtttcatggt aaactaacaa ctggaggtgc atgttatgta tgcgacgatg gaatccgtgc 1408381 ggcttcaaag tgaagctcag cagcttgccg agatgattct gcagtcggag acggctgaga 1408441 actaccgcaa ttgttacaag cgtctccagg aagatgaaga ggcaggtcgg attattcgtt 1408501 cttttatcaa aataaaagag cagtatgagg atgtacagcg ttttggcaaa tatcatcctg 1408561 actatagaga aatatcccgg aaaatgaggg agatcaaacg tgagctggac ctgaacgata 1408621 aggtggctga cttcaagaga gctgaaaatg agctccagtc cattcttgat gaggtcagcg 1408681 ttgagattgg gacagctgtt tcggagcatg tgaaagttcc gactgggaac ccttattttg 1408741 acggtttgtc ttcatgcgga ggcggctgcg gttcaggcgg aagctgcgga tgtaaagtgt 1408801 cctgacgaga ctggccgtct cgtcttttac atataagaga aaacaggcag gtgattgtat 1408861 tggagaatag gcgccagggc atggttgtgt atctgcactc cctaaagcag agcaaaatgc 1408921 tgaggaagtt cgggaatgtg cactatgtat caaaacgatt aaaatatgtc gtactgtact 1408981 gtgatatgga ccaaattgaa aaaacaatgg acaagattgc gtcttactca tttgtgaaaa 1409041 aagtggagcc ttcttataaa ccgtttttaa aattggaatt cgagtcaaag cttgataagg 1409101 caaaagaata cgattataaa atcggcatat agctataaaa aaatccccgc aggcatctgc 1409161 ggggtccttc tattccttaa tatgttaagg agaaggcaaa gggagaggag aaaccggagg 1409221 aagaacttat ggggaaacgt aagtcttctc cgcggttggc aacaacatcc tctagatgct 1409281 gttgcttata gtatggacaa ggatcatgct gcctatacac ctgtttatca agattagcgt 1409341 tcattgtttg gaagaatgct ttatgttaag ataggattga tttttttcta tgtacatagc 1409401 ggcgtccggc cgaataaaga aacaaaatag cttttagaaa aagtggtgtg gaacatgaga 1409461 gtaatttctg gatcaaaaaa aggccgttca ctaaaggctg tagccggaac atcaacaaga 1409521 ccgacaaccg acaaagtgaa ggaatccatt ttcaatatga tcggccctta ttttgacggg 1409581 ggcaggggac ttgacttatt cgcagggagc ggaggtcttg gaatcgaagc gctttcacgc 1409641 gggtttgagc attgtatatt cgttgaccgt gattttaaag cgattcaaac ggtaaaatct 1409701 aatttgaaaa cgctggagct tacaaaacat gcacaggtat accgcaatga tgcggaacgt 1409761 gctttgcacg ctgctgctaa aagagaaacc ggctttcgcg gaatttttct cgatccgccg 1409821 tataaggaac aaaagctgaa agcactttta actttgattg acgaatatca aatgctggaa 1409881 gaagacggct ttatcgtcgc tgagcatgac agagaggtcg agcttcccga aaccgtagga 1409941 gatcttgtga tgacaagaaa agaaacctat gggttaacag gtgtagcgat ttataaaaag 1410001 agggggtagt gaggtggcga gtatagctgt ctgtcccggc agttttgatc ctgtgaccta 1410061 cgggcatctg gacatcatca aacgcggggc gcatattttt gaacaagtgt atgtatgtgt 1410121 gctgaataat tcttcaaaaa agcctttgtt cagtgtggaa gaacggtgtg agcttctgag 1410181 agaagtcaca aaagacattc cgaacataac agttgaaaca tcgcaaggcc tgttaattga 1410241 ttatgcaaaa agaaaaaatg cgaaagcgat tttaagaggc ttgagagctg tatctgattt 1410301 tgaatacgag atgcagggga catcagtaaa ccgggtgctt gatgaatcta ttgagacgtt 1410361 ttttatgatg acaaacaatc aatattcgtt tctaagttca agcatcgtaa aagaagtggc 1410421 aagatacaac ggctcggtat cagagtttgt accgccggaa gtagagttgg cgcttcagca 1410481 aaaattcaga caaggatgag ggttttgact catccttttt ttgttccgtt tgtcagtctg 1410541 taagaaaaaa tgataatgta cgtaaacagc gcgcatagtg tgacagcagg tccgatctgc 1410601 acaagcagat tccagccgtt tataaaggca gttgacatgt cactgctgtt aagagattta 1410661 aatacatact gatacggatc atgccatgct gtgtaaagag gtttccataa aagcatgacg 1410721 aagacagcgg cataaacgcc ctgcagcaaa cgtgcgataa agaatggttt aaatctaatg 1410781 tcggtttccg ataaaatacc tgccacctga gcttgtacgg aaaagccgct aaacccaaga 1410841 ataaagctga cgataatggc tttttgcaga agagaaacat ctgtctcgct gacaagcttg 1410901 ctgcctaatg taatttcaaa catccctgat aaaagcggaa tgtccaattg agtcggaagc 1410961 tgaaacaaag tcagtgctcc ttttgtgaaa acagacaaaa catcagtcag ctggaccact 1411021 gacaacagcc gattgaagac agaaaataaa ataataaagc cgcctaccat aagaagcgtt 1411081 tgaacagaag acgtcacggc gtcgcctaaa attttaccta agggccgttt ttctgcaagt 1411141 ctggcggtat gaagagcgtg taaagcatct ttgactgaag ggaaaggtat cgttttcttt 1411201 cttctgagat gctgctcttc cttgcggcca taggagcgca ttgttaaacc gacggcaaga 1411261 ttccccaaat agtgtgcaga agctaataaa atgcctagtg atgcgttttg aaagaaaccg 1411321 acggcaacag cgccgaaaat aaagagcggg tttgaagaat tggtaaacga cgcgagccgt 1411381 tctgcctcta ctcttgaaat ctgattttcc tgccgcagac gggcagtgag ttttgcgccc 1411441 gctgggtttc ctgatgccat tcccatagca agaacgaagc cgccgacacc cggcacgcga 1411501 aagatcggcc gcataaaagg ctcaagcaaa acaccgacaa accgcacaat gccaaagccg 1411561 attaagagtt cggacagaat aaaaaatggc agcaatgacg gaaacacaac ctcccaccac 1411621 atagacagcc cggttttaga ggcttcgaat gaggcctgtg gatgtgagat gacagtcgct 1411681 gttaaaaaaa gaaaaaacga ggcaatcaaa agtgtattaa tcttcgacaa gttcattctt 1411741 acctccccga tgctaaaaat gcccaatgac atgtatatca tgataaaata atgtatgatg 1411801 taaaacggcc aagcagtacc tgtcctcttg attctttgta ctaatatacg agcatagggg 1411861 ttcagtttag accatagaat tcggtataca gggaattcag gcaggaggtt aacgctttgg 1411921 ccaaacctaa aatcgggtta gcgttaggat cgggaggggc cagagggctt gctcatctcg 1411981 gtgtgctttc cagtttacat aagcaccaaa ttgaagtgga tatgattgca ggaagcagca 1412041 tgggcgcttt ggtgggcagt ttttacgccg ccggacatga cgtggcaacg atgaaaaaag 1412101 tagccaaagc ctttaaacga aggctttatg ctgattatac ggtgccgaaa ctcggttttt 1412161 taaaaggtga ccgcgtcaga cagcttgtgc atgcttatac attcggaaaa ccgattgaag 1412221 agctccaaat cccgctgggc attgttgcgt gtgatctaca gacgggagaa aagattgtgt 1412281 tccgaaaagg atcagtgtca gatgcagtga gggccagcat cagcatcccg ggtatcttta 1412341 ttccgcagcg gctggacgga cgccttcttg tagacggcgc ggtcgtcgat cgaattccgg 1412401 tttctgttgt gaaagacatg ggagctgata ttatcatcgc ttcggatgtt tccagggttc 1412461 gaaaaactga aacagcagtg catatttttg atgtgattat gcaaagtatg gatatactgc 1412521 aaaatgaatt agtgcggcat caaacaattg ccgcagatat catgattcgc ccttcccttg 1412581 aaacatacag ctcaagctcg tttgccaata ttgaagaaat gatatcggca ggcgaagagg 1412641 cgacaaaccg aatgatcagc aagataagaa aagaaataga gaattgggag ggctcataat 1412701 ttgctacgta aaaaacattt tagctggatg ctcgtcatcc tcatactgat cgccgtttta 1412761 tcatttataa aacttccata ctatattaca aaaccgggag aagcgacaga gcttgcttca 1412821 ttgataaaag tggagggagg ctacccggaa aaaggaagtc tgtccttaat gactgttaaa 1412881 gtgggaccgg ctaatccatt tacatatgtg tgggcaaaga tgcaccctta ttatgaaatt 1412941 gttcctgatg agagcattaa ggaggaaggc gaatcagata aggagtatat gaaaagacag 1413001 ctccaaatga tgaaaagctc gcaagaaaat gcggttatag ccgcctatca aaaggcagga 1413061 aaaaaagtca gctattcctt taacggcata tacgcaagct cagttgtaga aaacatgccg 1413121 gcaaaaggga aaatagaagt cggtgataaa atcatcagcg cagacggcaa aaactatcag 1413181 tctgctgaaa agctgattga ttatatcagc agcaaaaaag cgggagataa agtcacgtta 1413241 aagatcgaaa gagaagaaaa agaaaagcgt gtcaccctta cgttaaaaca atttcctgat 1413301 gagccggatc gggcaggaat cggagtttcg ctttatacag acagaaacgt gaaggtagag 1413361 cctgatattg attttgaaat cgaaaatatt ggcggcccgt cagcagggtt aatgatgtcc 1413421 cttgaaatct ataatcagct gacaaaacca gacgaaacaa aaggctacga tattgcggga 1413481 acaggtacga ttgatgttga cggaaaagta ggcccgatcg gcggcattga tcaaaaagtc 1413541 gtcgccgcag acaaagccgg aaaagacatt ttcttcgcgc caaatcaaaa cggcgccagc 1413601 aattccgatt ataagaacgc agtaaaaaca gcaaaagata ttgattcaaa tatgaagatt 1413661 gtgcctgttg ataccatgca ggatgcgatt gattatttga ataagctgaa agcgaaaagc 1413721 acctgattct caggtgcttt ttctatacat ttaaaaagtg ttgttcatct tcgtcatatc 1413781 gaatcggtgc atgtccgtat tcctgtaggt caaactcagt tctcagcggc tcttctatcg 1413841 gcaggctgta aatcctgctt gcttttacgt ccagatcgag agctggatgg gagaaagagg 1413901 acagtttgct gacaagcgga acagacagtg cttttttctt ttcggataaa taagcctgtc 1413961 cttttttcgt catgccgaga agcctgatat acggcgcctt atcgttgtca agcagctttt 1414021 gcatatcctg tttttttgtt ctggttaaaa tgtgtgtatt catccgctgg agccttgtcc 1414081 acgtatagcg ttttgttttc agcagttcca taaattcctg ataggagctg gattttctga 1414141 tcgaacgaat aattctgtgc tctaaacctt cctccacctc gtatacttgc tgtaattccc 1414201 gtgccgttac agttgaaagg ctgtatttta agtaagaaaa gtagctttca ggtgtatgcc 1414261 acaatccgaa agatttgcgg taagctgcta attcacgtgc agatgcagca gggagaaaac 1414321 gaaggcaggc ttcgagattc tggccaatca tcgcttttct aatgcttgtg gcacttgcta 1414381 tatggttttc gccttcaggg agatcggcat catgatagtc cgaagagatt cgtgccgtag 1414441 tataaggttt cataggatat cccccggtta gaatcgaggt cacatactgg tatcccaaaa 1414501 tgttatttgg ttttgacaag tcaagtgcac tttcagtatg caaaatggag ctgaaggcga 1414561 tagccgccgc tgctgggtaa ctggccccct ttttaagttc ttctttaatt cggtcattca 1414621 atatatgttt atgctcatca ataagctgtg ctgtttctaa aaaaggcttg atatccccat 1414681 tttcactccc gaaaaacagc gcctcacatt caagttcgtt caggatggaa acactgccgc 1414741 gtgcaaaaat gtctgctttt tgcacggcat aaagataagg cagctcaatg acaagatcaa 1414801 ctccgctttg cagcgccatt tttgttcggg cccattttga tacaacagcg ggttccccgc 1414861 gctgtaaaaa atgtccgctc atgaccgcga cagccgtgtc acatccggtt tgcagctttg 1414921 ctgtttgggc atgataaagg tgaccgttat gaaagggatt atattcaacc accaatccga 1414981 cagctttcat attttttccg cctttcttgc tatgtttaaa aacgtatggt acatttgcaa 1415041 atgaaaactc ttacgcctta tttttgtttt aagtgtatgc atagcatatt ccgctgtcaa 1415101 cgatacttca atggcagcat tatgctgtaa agaaaaaata ttgacaaaaa caatcttaaa 1415161 agctataatc atgtttgttg ctttcctgag gtgatacaaa tgaaatggac gatttatcag 1415221 ctgcatcaaa tgccaaaaca aagttttgag tttgatgaaa cagttgagtt aaatgagctg 1415281 acaaagctga attctgacat tcgccgcatt tctcccgttc gggtgaaggg cagagcggat 1415341 atcaaatcca aacaggtttc gtttgatttt acaatttcag gcgaaatgct tttgccatgc 1415401 tcaagaacac tcgttgatgt tccgtatcca tttgaaattt caacaaaaga actgtttata 1415461 tttcatcaca cggatgatat agaagatgat gacgttcaca ttgttgagga cgatactatc 1415521 gacataactc cgatcgtgaa agaagaaatt cttttagaaa tccctatgca aatcttttgt 1415581 gaatctgaac aagaaaaagg agctgctcct caagaaggaa aggattggca agtcatttcg 1415641 gaagaagaca agaagaatca agttgatccg agacttgcag cccttgaaaa gctcttaaaa 1415701 caagatgatg aatcttaact ctttaaggag gtgggaataa tggctgtacc ttttagaaga 1415761 acttctaaaa tgaagaaaag attgcgccgt acacatttca aacttaatgt acctggtatg 1415821 acagaatgtc cgtcatgcgg agagatgaag ttgtctcacc gtgtatgcaa agcatgcgga 1415881 tcatacaacg gcaaagacat aaatgtaaaa agtaactaat gagaaaagcg cagggtgaaa 1415941 gccctgcgct ttttcttttt ctcttcctgt cagcttgcgg aaaatttgtg agtgcaaata 1416001 gtctatctaa tctattaccg gcatatgtat gagataaata agctgacatg gagggagatt 1416061 gaatttgacc attacaagac aagatgcttg gactcaggat gaggatttgc tgctggcaga 1416121 agtggtgctt cgtcatattc gagagggagg aacacagctt tcagcctttg aggaggttgg 1416181 aagggcgctg accagaaccg cggcagcctg tggtttcagg tggaactcgt atgtgagaaa 1416241 acaataccag tcaggtatag agcttgcaaa aaagcaaagg aaagaactga gaaagcaaat 1416301 cggcgttcat tcggtcaata tgccgaattc catgaagcag actgcctcgg catcgtcaga 1416361 aggaaaacga gatttgtcca ttcaggatgt cattcaattt ctcgaacaat tcaaagaaac 1416421 accgtctgca caagaatttc agcttgaaag ggaaaaattg aaggagcaaa tccaatcgct 1416481 gcaaaaagag cttgaggatt tgcggagtga aaatcagaca ttgcggaatc agctagagat 1416541 gacagaagag gattacaagg cactgatcga tatcatggat cgggccagaa aaatggttgt 1416601 ttcgaaggaa gacggaagaa tgaaaaaagc ggctcaagaa acgtaaagaa acgcctgaaa 1416661 tgaaccggcc ctatagtaag aataggccgg ttgttttgat ttctatgcag actctcccgg 1416721 tgtcatttcg cgatccatat caggatgcca gatgagcggg ttttcccctt tgtcccgcgc 1416781 catatcatac ttaacagttt taaagttcat tttgttccaa aattccgctg atttcattct 1416841 cggatttgtc cggatcggca ttttgaatga ttttgcaaat tcaaccaagg ctctcccgta 1416901 tcccctgttc tggtagcccg gaagaacctc aagcttccac agctccaaat aatcctggcg 1416961 gttgtcaaaa tagggattcg atttgccgtt aacttgatac agactcattc gtgctacaag 1417021 tttatcgcca aaataaatcc cgtaaaaagg cgaggtgctg tcattttcaa taatattatc 1417081 ctgaagttct tcaagcattg aaagctcctg aatgccgtat tctttgaatt tcttgaattc 1417141 ttccagcgtt ttatagttga taagcagacg ttctaccttt gtcaaacaaa tctccccctt 1417201 tgttgtttct acatatattg taaacgcttt atttaaaaaa tccaaatatt taaactttaa 1417261 ttttaagcac atgggatctt tgagaagtaa tttcttctta cttctgctat gataatacgt 1417321 aaatgctaaa ttgggtgtga catcatgaaa attggaatta tcggcggagg ctccgttggt 1417381 cttttatgcg cctattattt gtcactttat cacgacgtga ctgttgtgac gaggcggcaa 1417441 gaacaggctg cggccattca gtctgaagga atccggcttt ataaaggcgg ggaggaattc 1417501 agggctgatt gcagtgcgga cacgagtatc aattcggact ttgacctgct tgtcgtgaca 1417561 gtgaagcagc atcagcttca atctgttttt tcgtcgcttg aacgaatcgg gaagacgaat 1417621 atattatttt tgcaaaacgg catggggcat atccacgacc taaaagactg gcacgttggc 1417681 cattccattt atgttggaat cgttgagcac ggagctgtaa gaaaatcgga tacagctgtt 1417741 gatcatacag gcctaggtgc gataaaatgg agcgcgttcg acgatgctga accagaccgg 1417801 ctgaacatct tgtttcagca taaccattcg gattttccga tttattatga gacggattgg 1417861 taccgtctgc tgacgggcaa gctgattgta aatgcgtgta ttaatccttt aactgcgtta 1417921 ttgcaagtga aaaatggaga actgctgaca acgccagctt atctggcttt tatgaagctg 1417981 gtatttcagg aggcatgccg cattttaaaa cttgaaaatg aagaaaaggc ttgggagcgg 1418041 gttcaggccg tttgtgggca aacgaaagag aatcgttcat caatgctggt tgacgtcatt 1418101 ggaggccggc agacggaagc tgacgccatt atcggatact tattgaagga agcaagtctt 1418161 caaggtcttg atgccgtcca cctagagttt ttatatggca gcatcaaagc attggagcga 1418221 aatacaaaca aagtcttttg agctttttcg gtaacatgct atactcattt cggatcacta 1418281 actatttatt ggagaaagga agttctagaa gatgcagcta actgaacttt ccatcaaaaa 1418341 tcagaatgtg tttgtacagc actatataga tggcaaagaa gaaatgtctt ctttttttga 1418401 ttacagtatt catcataagg acatgtggcg cgaaagactg gaagacttat cttcccggtt 1418461 tttcgcaaga gaggaattgg cggcgtactt aacctcttac cataataaat tcggttcaag 1418521 tgcgatgcag tctgctattg agaagctgaa ggacccgtca agtgccgctg tagtcggcgg 1418581 acagcaggca ggacttttaa caggaccgct ttacaccata cataaaatca tttcaatcat 1418641 tgttttagca aagcaacaag aaaaggaact gcaagtgcct gtcataccaa tcttctgggt 1418701 ggctggagaa gaccacgatt tggatgagat taattttgtt cacacatctg aagagaatgg 1418761 gcctgtgaaa aaaaagctgc ctcagtctta ttggaagaaa tcatcagcag cgagtacatc 1418821 gcttgatcag gaaaagtgtg ccgcgtggat agatgatgtt tttgccgctt ttgaagaaac 1418881 agaccatacg aatacacttc tcgacaatgt gaaacgatgt ttaagggaat ctgttacgtt 1418941 tactgacttc tttgaactgc tgatcgcgga tttgttccaa gaagagggct tagttttatt 1419001 aaattctggg gatccgggga ttaaaaagct ggaaacggcc atgttccaaa agattcttcg 1419061 agaaaatgat gaactcgccc gggctgtatc agatcagcag gccttcatgc gtcaagcagg 1419121 ctacaaaccg attatcgagt ccggaaaaga gcaggcgaat ctgttttatg aatacgaaga 1419181 tgagcgtttt ttaattgaaa aagataacgg ccgatttgtc atcaaagagc ttgatctagg 1419241 atggacgagg gatgaacttc atacacatat ggaagaacat ccagagcgtt tcagcaacaa 1419301 tgttgtaacg agaccgttaa tgcaggaatt tctcattccg actttagcat ttattgcagg 1419361 gcctggggaa atcaattatt ggggcgagct caaacaggca tttgcggtga tgggcttcaa 1419421 aatgcctcct gtcatgccaa ggctgaacat tacgatactt gagcggcata ttgagaaaaa 1419481 actggctgaa cggaatatct cattacaaga cgcgattgag cgcggaacgg agaatcaaag 1419541 agagacatac ttcgagcgcc agattccgga agagtttacg gcggtgatgg atcaggcgaa 1419601 aagccaaatt gaagcgattc acaaaacggt ccggcaggag gcgttaaagg ttgatcaaag 1419661 cttggaacct ttacttctga aaaatgccgc ttttattcag gatcagcttc aattcttaga 1419721 gcgcacggtg atgaagcgaa ttgaagaaaa agaaggctac gtcttgaagg attatgaaag 1419781 aattcaaaat agcattaagc cgcttcttgc gccgcaagaa cggatttgga atatcatgta 1419841 ttatttgaac aggtacggtc caaaattctt cacgacattc aagaatctgc cattttcttt 1419901 tcaaaatcaa catcaagttg tcaaactttg aaataaagtt ttaaagaacc ctgactagtt 1419961 cagggttttt ttttatgggt aaacagtgta aaatgaagtt gtggagcgaa gtggtgaata 1420021 gtggtgagtt aaggagagaa agtggggcaa gagatcatgt ttatgggtga atatcagcat 1420081 accatcgatg cgaaaggccg catgatcgta cccgctaaat tcagagaagg cctaggtgag 1420141 caatttgtgc tgactagagg acttgaccaa tgtctcttcg gctaccctat gcacgaatgg 1420201 aaacaaattg aagaaaaact aaaagctctt cctctcacaa agaaagatgc ccgcgcgttt 1420261 acccgtttct tcttttcagg ggcgactgaa tgcgaactgg ataagcaagg cagggtaaat 1420321 atcgcatcat ctctattgaa ttacgccaaa ctggaaaaag aatgtgttgt tatcggggtt 1420381 tctaatcgaa ttgaattgtg gagtaaagta atttgggaac aatacacaga agagcaagaa 1420441 gattcatttg ctgaaattgc tgaaaacatg attgggtttg atatataatg attcttcgtg 1420501 tataacactc taaaaacaat ttcaattcat cctgataaaa ggtgggacca acacaatatg 1420561 tttcaacaca agacagtact tcttcgtgaa accgtagacg gacttaatat taaaccagac 1420621 ggtacatatg tagactgcac actcggcgga gctgggcata gtacatactt attgcagcag 1420681 ttatccgaga aggggcgttt aatcgctttt gaccaagatg atacggcatt acagcatgct 1420741 aaagaagtgt tgtccgatta taaaggacag ctcattctga ttaaaagcaa tttcaggtat 1420801 ttaaaagaat atttgaatga acaaggcgtt acagaagtag acggcatttt atttgattta 1420861 ggggtgtcct ctccgcagct ggatacaccg gagcgcggat tcagttacca tcatgacgca 1420921 ccgttggaca tgaggatgga ccagtcggct acgctttcgg cgaaagaagt cgttaatgag 1420981 tggcgctatg aggatctcgt ccgtattttc tttaaatacg gagaagagaa gttcagtaaa 1421041 cagatcgcca gaaaaattga ggaggcaaga atgaagtctc ctattcaaac tacgggccaa 1421101 ctggtcgatc taataaaaga cgcgattccc gctccagcga gaaggagcgg gggacatccc 1421161 gctaaacgcg tgtttcaggc aatcagaatt gccgtaaacg atgaacttag ggtgtttgaa 1421221 gaagctttgg agcaggcaat tgaggttctg aagccagggg gcagggtatc ggtcattacc 1421281 ttccactcgc tagaagacag aatttgcaaa accactttta aagaaaagtc gtcgcttccg 1421341 gaacttcctc cgggacttcc tgttataccg gaagagtttg aaccggagct gaagctcatc 1421401 acacgaaaac cgattacggc atctcaagaa gagcttgaag agaacaaccg ggctcgttct 1421461 gccaagcttc ggattgctga aaaaagaaaa taacgaaacg cgaacgcaaa attaaaagga 1421521 ggtcatcagc ctatgagcaa tttagcttac caaccagaga aacagcagcg gcatgcgatc 1421581 agtcctgaga aaaaagtgat tgtcaagaaa agggcttcca ttactctcgg agaaaaagtg 1421641 cttcttgtcc tctttgctgc ggcggtgctc agcgtatcgc ttttgatcgt atcgaaggcg 1421701 tatgcggcat atcaaaccaa tattgaggtg caaaagcttg aggagcaaat ttcatccgaa 1421761 aataagcaaa ttggtgacct cgaaaaaagc gttgctgatt taagcaaacc gcagcgcatt 1421821 atggacattg cgaaaaagaa cggcttgaat ttaaaagata aaaaagtgaa aaacatacag 1421881 gaatgattca aatgccaaaa aagaataaat ttatgaatag aggagcagcg attctaagta 1421941 tttgtttcgc tctctttttc tttgtcatcc tggggagaat ggcatatatt caaataaccg 1422001 gaaaagcgaa cggcgaagtg cttgcgacaa aagcgacaga gcagcatgaa aagaaacgga 1422061 ccatcgaagc gagccgcggc tcgattttag accgaaaagg aaaagtcatt gcagaggaca 1422121 cagcgacgta taaactgatt gcgattctcg ataaaaaaat gaccactgat gtcaagcatc 1422181 ctcagcatgt tgtaaacaaa gaaaaaacgg cggaagcatt gtctaaagtg ataaacttgg 1422241 acaaggccga catccttgat atcttaaata aagatgcaaa acaagtcgag tttggctcag 1422301 ctggccggga tattacgtat tcacaaaagc aaaaaatcga aaaaatgaaa ctcccgggca 1422361 tttcattttt acgggataca aaacgctact atccaaacgg agtatttgca tctaatctaa 1422421 tcggctatgc cgaggttgat gaagaaacaa atgaaatttc cggcgcgatg ggattagaaa 1422481 aagtgctgga taagtatttg aaggagcggg acggatatgt gacatatgaa agcgacaaat 1422541 ccggctggga gctcccgaac agcaaaaata aaattacagc gccaaaaaat ggtgacaatg 1422601 tatatttaac cattgaccag aaaattcaaa cctttttgga agacagcatg acaaaagtgg 1422661 cgcaaaagta taatccgaaa aaaatcatgg ccgcagtcgt tgatccgaaa acgggcaaag 1422721 tccttgccat gggacagcgc ccaagctttg atccgaacaa gcgcgatgtg acaaactact 1422781 ataatgattt gatttcatat gcgtatgaac ccgggtccac gatgaagatc tttacactcg 1422841 ctgctgcgat gcaggaaaac gtgtttaatg cgaacgaaaa atataaatca gggacatttg 1422901 aagttggcgg agcacctgtt aaggatcaca ataacggtgt aggctggggt ccgacaacat 1422961 atcatgacgg cgtcctaagg tcgtcgaatg tcgcttttgc gaaactggcg aaagaaaagc 1423021 tgggatatga ccgcctcaat caatatttgc acaaattcaa tttttaccag aaaacaggta 1423081 ttgatttgcc aggagaagtc tccagcaaaa tcaactttaa atatgaattt gataaggcgt 1423141 caactgcata tggccaagcg tctgcggtca caccaattca gcagattcag gccgcaacgg 1423201 caattgcaaa tgacggtaaa atgatgaaac cttatgtcat tgaccatatc gttgaccctg 1423261 ataaagataa aactatttat caaaataagc cggaatcagc cggaactcca atttctgcaa 1423321 gtactgcgaa aaaggtgcgg gatatattag gagaagtcgt tacatcgaag atcggaacag 1423381 ggcaagctta taaaatcgaa ggttttgatg ttgccgggaa aacaggtact gcgcaaatag 1423441 ccggtaaagg cggatattta gacggcacag ataactatat cttttcgttt atgggtatgg 1423501 cgccaaaaga tgatcctgag cttttaattt atgttgctgt acagcagccg caactaaaag 1423561 caggacaaag cagttcagat ccagtatcag aaatcttcaa tccaacaatg aaaaatagcc 1423621 tgcactacct aaacatcgaa ccaactgaaa aatctgactc agataaggaa gaaacaaaag 1423681 cgcagacaat gcctgattta acagatcaaa cggtagctgc tgctcaaaag aaagcaaaag 1423741 aggagaatct cacaccaatt gtcatcggca gtgatgtcgc tgtaaaagaa cagtatccga 1423801 aagcggatga ggaagttctc accaatcaaa aggtcttcct gaaaacgggc ggcaaaatca 1423861 aaatgcctga tatgacaggc tggtcgagaa gagaggttct gcagtacggc gagctcgcgg 1423921 gaattcatat tgaagtaagc ggacaaggct acgctgtcag ccaaagtgtt aagaaagaca 1423981 aagaaatcaa agacaaaacc gtaatcaagg ttaagtttaa aaatcctgat taaaaagaaa 1424041 gccgtcgtta tgcaggcttt ctttttttat gccttcagag gagcatcgtt ctacctgtcc 1424101 aaattcaggc ataaaatgaa acaagcctaa ataaggagtg aacggtctct tgcgcgtctc 1424161 gaatgtaacg gttagaaaac gtttattatt tgttttgctt tttggcgtga tcgtgtttct 1424221 gatcattgat acaaggctgg ggtatgttca gtttgtgatg ggcgaaaaac tgacttcgct 1424281 agcgaaagat tcctggagcc ggaacttgcc gtttgagccg gagagaggcg agattctgga 1424341 tcggaatggt gtgaagctcg caacaaataa aagtgcgccg accgtattcg tcgtgccgcg 1424401 ccaagttcag aatccgatga aaacgagcaa gcagcttgcg gcggtgctca atatgtcaga 1424461 agaaaaagta tataaacatg tgacaaaaaa agcgtcaatc gaaaagatca ctcctgaagg 1424521 gagaaaaatt tcaaatgaga aggcgaaaga aatcaaagcg cttgatttaa aaggtgtgta 1424581 tgttgcggag gacagtatcc gtcattaccc gttcggcagc tttttatctc atgtgcttgg 1424641 atttgcagga attgacaacc aagggctcct tggacttgaa gcctattacg acgatgattt 1424701 aaaaggggaa aaaggttctg ttaagtttta tacagatgcc aaggggaaga agatgcctga 1424761 tgaagcggat gactatacgc cgcctaagga tgggcttgat atgaagctga cagttgattc 1424821 aaaggttcag acgataatgg aaagagagct tgataacgct gaggccaaat atcatccgga 1424881 cggcatgatt gccgtagcca tgaatccgaa aaacggagaa attttgggga tgtctagcag 1424941 gcctgacttc gaccctgctg attaccaatc tgttgatccg tccgtctaca atcgaaatct 1425001 gccagtatgg agcacgtatg aaccgggatc tacctttaaa attattacac ttgcagcagc 1425061 ccttgaagag caaaaagtaa atttgaaacg ggatcaattt tatgataaag ggcatgctga 1425121 agtggacgga gcgagactgc ggtgctggaa aagaggcggg cacgggctgc agacgtatct 1425181 ggaagttgtg cagaactcct gcaacccggg gtttgttgaa ttaggcgagc gcttaggaaa 1425241 ggaaaagctt ttcaaatata tcaaagactt tggttttgga caaaaaacgg ggattgatct 1425301 ccaaggcgag ggaacaggca tcttattccc gcttgagaga gtgggcccgg tggagcaagc 1425361 aactacggct ttcggacagg gagtatccgt cacgccgatt cagcaggttg cagcagtatc 1425421 cgccgctgta aacggaggaa cgctctatac accttatatt gcaaaggaat ggatcgatcc 1425481 tgttacgaag aaaacggtca aaaaacaatc accaatcgca aagaaacaag tcatttctga 1425541 ggaaacatcc aaacaaatcc gctatgctct agaaagcgtc gtcgcagaag gaaccggccg 1425601 caatgcattt gtagaaggat atcgtgtcgg aggaaaaacg ggaactgcac aaaaggttaa 1425661 agatggaaaa tatcttgaaa acaaccatat tgtatcattt atcggtttcg cgccagcaga 1425721 tgatccgagt ctagtcgtct acgttgcggt ggataacccg aaaggcacga ttcagtttgg 1425781 cggaacggtg gcagcgccta ttgtcggaaa tattatgaga gacagtctgc cggaacttgg 1425841 tgtgaagccc cggaaaaatc aaatcgagaa aaaataccaa tggaacgaca caaaaacaat 1425901 agaagttccg aatgttgtag ggatgtctgt ctcagatctt gagtcactat tggtgaatct 1425961 caatgtggat gcttccggga aagggagcaa aatcgttaaa caatcgccag ctgccggaac 1426021 gaaagtaaaa gaaggctcaa agatacgcgt gtatttgact gaagaagatg aaaaggaggc 1426081 agccgattga ttcgggctgc ctattctttt attgcagaaa aaatgctgat atctttcaag 1426141 attagctgga tgtatccttt tatttacgct aaaatatgaa ctgtatgctt aaaatcatta 1426201 ccacatcatt tgatgtgact tcaatgataa aaagaacgaa ttagaatgtt gagaggtttg 1426261 atacgatgaa acttacaaag ctgcttacat acttaacaac cgaaccttct gtaaacgact 1426321 cacaagaccc tgaaataact tcaattgaga tggactccag ggaagtaaag aaagggagtc 1426381 tttttgtatg tgtaaaaggg tatacggtgg atggccacga ttttgcgcaa aaagcagtag 1426441 aaaacggtgc agcggctatt gtggcagaaa gagaggtcga tgtgaatgtt cctgttatta 1426501 ttgtccggca gtcacttcgc gcgctcagcg ttttgtctga tgcgttttac ggacagccga 1426561 cgaagaagct tcagctgatt gggataacag ggacaaacgg caaaacatca acgacccaca 1426621 tggtcgatga gattctgaaa aaagcgggaa aacgcacagg cttgatcggt acaatgtaca 1426681 tgaaaatcgg agacgaaaca cttcctgtta aaaacacgac tccggaaagc gtcacgctgc 1426741 agaaaacgtt taagaaaatg aatgacaagc acgttgacac tgcaatcatg gaggtttctt 1426801 cccacgcttt gtctttagga cgcgtccatg gctgtgatta tgatattgcc gtgtttacga 1426861 atttaacaca ggaccatctg gactatcata aaacgatgga tgagtaccgg catgcaaaaa 1426921 gcttgctctt ttcccaactt ggcggggctt tcaaccatga acatccaaag cgtgccgtcc 1426981 tgaatgctga cgatgaggcg agcgcttatt ttgaaaaggt aacagctgcg catatctcta 1427041 catacggaat taaaaacgat gctgatgtga tggcgaagaa catcagtatc actgcacagg 1427101 gcacaagctt tgatctcgtg acaaacaaag gcacgaagca catcacgatg tctctcgtcg 1427161 gacaatttaa tgtgtataac gtgctggccg ctgttgcgac atgtattgca gcaggcatac 1427221 cgtttgaaat catcactgag gctgttgaag aattgcatgg tgtaagaggc cgttttgaat 1427281 tggtcaatca gcagcaggag tttcctgtca ttgtagacta cgcgcacaca ccggacagcc 1427341 ttgaaaatgt gctggagaca tgcagagaca tgacggaagg aaagctattt gtcgttgtcg 1427401 gctgcggagg agacagagat aagacgaagc gcccgaaaat ggctaaaatt gctgtggagc 1427461 tggctgacga gccgattttc acgtcagata acccgagaag cgaagatcct cgcgcgattt 1427521 taagagatat ggaagccgga gtagagaacg catactatca cagtattgca aaccgcgagc 1427581 aggcgatctt tttcgcaatt gccaatgcca aaaaaggcga cgttgtcctc attgccggaa 1427641 aaggacatga aacctatcag cagatcggaa atgaaacttt cgattttgat gatgctgaag 1427701 tagcggcgag agccattgtt gaactcaata agaataagac gaattcatag gaaagagatg 1427761 ttactgaata atggagcttg aaaagatttt tcatatggaa aaaaatcatg aatatgataa 1427821 ctacgtatgt cgtttgaaag aaacaggagg agaaaaggac aatgcttgag caagtcattc 1427881 tgtttacaat tttaatgggg tttttaatta gtgttctgct ctctccgatt cttattccgt 1427941 ttttaagaag attaaaattc ggccagagta ttagagaaga aggaccgaaa tcacatcaga 1428001 aaaaatcagg gacaccgaca atgggcgggg tcatgatcat actttctatc atagtgacaa 1428061 caattgttat gacacagaag ttttcagaaa taagccccga aatggtgctg cttctgtttg 1428121 ttacgctagg ctacggtttg cttggctttt tagatgatta catcaaggtt gtcatgaagc 1428181 gcaatcttgg attgacatca aagcaaaagc tgatcggaca aattattatt gcggttgtat 1428241 tttacgccgt gtatcattac tacaattttg cgacggatat tcgcattcct ggaactgact 1428301 tatcatttga tcttggctgg gcttacttta tccttgtgct ctttatgcta gtcggcggat 1428361 caaacgcagt taacctgact gacggccttg acgggttatt atccggtact gcggcgattg 1428421 cctttggcgc ctttgccatt ctggcatgga atcagtctca atatgacgta gcgattttct 1428481 cagttgccgt tgtcggtgca gttctgggct tccttgtatt taatgctcat ccggccaaag 1428541 tttttatggg agatacggga tcgcttgcat tgggaggagc catcgttacc attgccattt 1428601 taacgaaatt agagatcctg ctggttatca tcggcggtgt attcgttatc gagacattat 1428661 ccgttatttt gcaggtcatc agctttaaaa cgacaggtaa acgaatcttt aaaatgagtc 1428721 cgcttcatca ccattatgag cttgtcggct ggtctgaatg gagagtagtc gtgacgtttt 1428781 gggctgcggg acttttgctt gccgttttag gaatttacat cgaggtgtgg ttataagtgg 1428841 aaaatgatca atttttacag aaacagcatt ttttaatcct tgggcttgcg aaaagcggat 1428901 atgcggcggc ctccattctt catgaaaaag gcatttatgt tgcagtcaat gatcaaaagc 1428961 cttttgaaga aaatgaaccg gcacaaaagc tttctgaaaa aggaatcgaa gttgtttgcg 1429021 gagagcatcc agtttctctg ttcgatcagc atcaaatcac gattctgatc aaaaacccgg 1429081 gaattcctta tgaaaatatc atggttcagg aagcagagaa acgaggtatt ccggtttgga 1429141 cggaaattga gctcgcttac tacctgacca gcgccaagtt tatcgggatt accggatcga 1429201 acggtaaaac gaccacgaca acgctaattt acgaaatgct caaggctgac tcgcaaaaag 1429261 cactgattgc cggaaacatc ggcacagtcg caagtgaggt tgcctatcat gctgatggag 1429321 atgaatggat cgttaccgaa ctgtcttcgt ttcagctgat gggaacacac gctttcagac 1429381 cggaaatcag cctgatttta aatgtatttg acgcccatct ggattatcac catacgcgcg 1429441 aaaactatga aaaagcgaaa cagaaagtgt accttcatca gactgcttca gataaagcta 1429501 ttgtcaacca ggatgatgaa accgtcgtgc gtcttgctga agccggaaaa gccgaaatcg 1429561 tcccattttc agtcagcaaa acgcttgaac agggcgcata tgtaaaagac agtatgatta 1429621 tgtttaacgg cgaagccatt cttcctctgg aagaggttgt actgcccggt gctcataacc 1429681 tggagaacat tttagcagct attgcagttg tgaaaacggc aggagcatcc aatgaggcgg 1429741 ttaaaaaggt gctgacaagc tttactggtg tgaagcaccg cctccaatat gtcacaactg 1429801 tgaatggccg caaattttat aacgacagta aagcaacaaa cattctggcg acaagcaagg 1429861 cgctttcagc ttttgataag ccggtcattc tgcttgcggg cggactggat cgcggaaatg 1429921 gttttgatga cttgaaacct tatatgaagc atgtcaaagc agtgcttaca tttggccaga 1429981 cggcgccaaa actcgagaaa ctcggcaatg aactgggaat acaacatgtc aaacgtgtcg 1430041 ataatgttga acaagcagta tctgcggcgt ttgcgctctc aaatgaagga gatgtcatcc 1430101 tgctgtcacc cgcgtgtgcg agctgggatc aattcaaaac atttgaagaa cgcggtgaca 1430161 tgtttataga tgccgtgcat atgcttaagt aagggcttgt cttgaagtaa atcggcagcc 1430221 ctaatgactt taagcttggg gtgtcgattg ctttgactac taaaaaaaca tcgcctgatt 1430281 tgttattggt catcattacg ttattattat taacaatcgg attaattatg gtgtacagtg 1430341 cgagtgcggt atgggcggat tataaatttg acgactcatt ctttttcgcg aaacggcagc 1430401 ttttgtttgc gggaatcggc gtcattgcta tgttttttat catgaatgtt gattattgga 1430461 cttggaggac atggtccaaa ttgctgatgg ttatctgctt tttccttctg gtgcttgttt 1430521 tgataccggg cgtcggaatg gtgcggaacg gttcaagaag ctggatcgga gtcggagcat 1430581 tcagcataca gccttcagag tttatgaagc ttgcgatgat tgcattcctt gctaaatttc 1430641 tctctgaaaa acaaaaaaac atcacatcgt tcagacgggg gttcgtccct gcacttggca 1430701 tcgtgttttc agcatttttg attatcatgt gccagcctga cctcggaacg gggacagtta 1430761 tggtcggaac ttgtattgtc atgatttttg tagccggcgc acggatcgcc catttcgtct 1430821 ttctcgggct gatcggcctc agcggatttg tcgggctcgt actatcggct ccatatcgga 1430881 taaagcggat tacctcatac ttaaatccat gggaagaccc gctcggaagc ggatttcaga 1430941 tcattcaatc gctttatgca gtggggcccg gcgggttgtt cggaatgggg ctcggacaaa 1431001 gcagacagaa gttcttttat ctgcctgagc cgcaaacaga ctttattttc gccatcttgt 1431061 cagaggagct gggctttatc gggggaacac ttattttgct cctcttcagc gtcctgctgt 1431121 ggagaggaat cagaattgcg cttggtgcgc ctgatctgta cggaagcttt gtcgcagtcg 1431181 gcattatttc aatgattgcc attcaagtca tgataaatat cggcgtagtc acgggcctga 1431241 ttcctgtaac aggcatcacg ctcccgtttc tgagctacgg aggctcttca ttgactctaa 1431301 tgctgatggc agttggtgtg ctgctgaatg taagccgcta ctcgaggtat taacgaatgt 1431361 atttccaagc ctcctgtcta acatgaagct tggaaacaat tgatgcgata accctgtcca 1431421 acaaaacagg gttatcgtta tgttatagag aaacttagac tgggggaaaa aagaaatgcg 1431481 aattgcaata agcggaggcg gtacaggggg acatatttat cctgctcttg cttttattaa 1431541 agaagtgcaa agacgtcatc ctaatgtgga atttttatat atcggaacag aaaacgggct 1431601 ggagaaaaaa attgttgagc gggagaatat accgtttcgt tcaattgaaa ttacaggatt 1431661 taaaagaaaa ttgtcatttg aaaatgtcaa gactgtgatg cgttttctga agggcgtcaa 1431721 aaagagtaaa tcgtatttag cggaatttaa gcccgatgcc gtaattggaa cgggcggtta 1431781 tgtatgtggg ccggttgtct atgccgctgc gaaaatggga attccgacta ttgtccacga 1431841 acaaaacagc ctgccgggca tcacgaataa gtttctttca aaatatgtta ataaagtagc 1431901 gatttgtttt gaagaagcga aatcacattt tcctagcgag aaagttgtat ttacgggaaa 1431961 cccgagagcc tctgaagtcg tctcaataaa gacgggacga tcattggctg aatttgggct 1432021 ttctgaagac aaaaaaacgg tcttaatttt cggcggaagc cgaggcgctg caccgattaa 1432081 ccgcgctgtc attgacatgc aggatgtgct gaaaacaaga gactatcaag tgctgtatat 1432141 caccggtgaa gttcactatg aaaaagtaat gaatgagctg aaaagcaagg gtgccgctga 1432201 taatatggtc acaaagccgt ttcttcatca aatgcctgag tatttaaagg ccattgatgt 1432261 cattgtggcc agagccggtg cgacaacgat tgccgaaatt actgctctcg gaatcccaag 1432321 tgttctgatc ccaagtccat atgtgacagc gaatcaccag gaggtcaatg cgaggtctct 1432381 tggccagcat gatgcggcga ttgtactgaa agaaacagag ctcagcgggg agaagctgat 1432441 tgaagcgcta gaccggattg tactgaatga gcaaacgtta aaggaaatga gcgaacgaac 1432501 aaagtcactc ggtgttcctg acgcggctgc ccgtttatac agcgtactcg aggaattaaa 1432561 aaaatagtag aaaagcaaat ggaatgcgga ggtttacgat ggagaaagtg atacaggaat 1432621 taaaagaacg agaagtcggc aaggttcttg caaatgaacc gctcgcgaat catacaacga 1432681 tgaaaatcgg cggacctgcg gatgtattgg tcattccaag cagtgtggat gctgttaaag 1432741 acatcatgga cgtgattaaa aaatatgatg tgaagtggac agtcatcggc cgcggatcaa 1432801 atcttcttgt tttagatgaa ggaattagag gcgtagtgat caagctgggg gcgggtcttg 1432861 accatttgga gcttgaaggg gaacaagtaa cagtcggagg cggttattcg gtggtccgcc 1432921 ttgctacatc attgagcaaa aaaggcctgt ccggtttgga atttgctgcc ggcattccag 1432981 gatcagtcgg cggagcggtt tatatgaatg ccggcgctca cggttctgat atgagcgaga 1433041 tcctcgtcaa agcgcatatt ttatttgaag acggaacgat tgagtggctg acaaatgagc 1433101 agatggattt cagctacagg acatctgtac tgcaaaagaa acgcccgggc gtttgccttg 1433161 aagctgtttt gcagcttgag cagaaggata aggaatcaat cgttcagcaa atgcaaagca 1433221 ataaagacta tagaaaaaat acacagccgt attcaagccc ttgtgcggga agcatattca 1433281 gaaatccgct tccgaatcat gccgggaacc ttgtagaaaa agcaggcttg aaaggatatc 1433341 aaatcggcgg tgcaaagata tcggagatgc acggaaactt catcgtcaat gcggggggag 1433401 catcagcaaa agatgtgctt gatctcattg accatgtgaa aaagacaatc cgtgaaaaat 1433461 acgagattga tatgcacaca gaggttgaaa tcatcggcgg aaatcgctga ttcaagttct 1433521 gactgaagct gttcatatga tatactgtaa gcaaacgaca aacggcatca tagtatgccg 1433581 tttgttttgg aatagacaga cttttaacag ctgtttcatt tgaatgaggt gaacaggcaa 1433641 tgaacccggg tcaagaccga gaaaaaatcg ttaacattga agagcggatc cctaaaatta 1433701 aagagcagag gaaacaaaag gcaaaccgcc gtctcatttc atttattatg ctctttttta 1433761 ttatggtgct gatcattgtg tacctgcaaa caccaatcag taaagtatca acaatctctg 1433821 ttacagggaa tgaaaatgta tcaaaaaagg aaattatcga cctttccgat attaacagcg 1433881 gagatactga gttttggagt ttggacaagc aaaaaacaga aaagaagatt cagcaaaata 1433941 aattagtgaa aaaagcggag atcagcaaat cgcttcctaa taaaatcaac attgcaatcg 1434001 aagaatataa agcgattgct tatttagaaa aagacgatgt gtactatgaa gtgcttgaaa 1434061 acggctcagt tctgccaaac gaagtaacgc cggatgatgc cggaccgatt ttagtgaatt 1434121 ggacaaacgc gaagaagcgg tctcaaatgg ccaagcagct cgatgcgttg tcaaattcgt 1434181 taaaacagtc gatttcagaa atttattata cgcctgtaaa aatggatgaa aaccgtatta 1434241 agttgtacat gaacgacggt tatgttgtta cggcatctat taaaacgttt gcagaccgaa 1434301 tgaagacgta tccttctatc atctcacagc taagcagcaa taaaaaagga atcattcatt 1434361 tagaagttgc cacctatttt gaagagtttg ggaaaaacga taaagctgct aaaaaggaag 1434421 atgaaaattg aggggcaaat cagcagtcct tctttccttg attatgctta tcgcaggttt 1434481 tttgatttca ttttcttttc aaatgacaaa agaaaacaac aaaagcgcgg ctgagacgga 1434541 agagtggaaa aaagaatatg cgctgagaga tgaactgctg aaacaagaga aagaaaataa 1434601 gaagtttgaa aaagaattat atcaaaagca aaacaaagtc cgccaggcgg aaaataagct 1434661 gaagaaagag aagtcggaat actataatgt cctcgaagat acagaaaaat acaggatgta 1434721 tattggggaa gtcggtgtgc agggagaagg cgttgaggtg acattggaag atgcgtcata 1434781 cataccggaa ggggagaatg tgaatagtta catcgttcac gaaagccata tcttccaagt 1434841 agtaaacgaa ctgtatatct caggagcggc agctgtcgcc gttaatggac agcgtttgac 1434901 gcatgattcg tatatcaaat gcaatggtcc tgtggtaacg gtagacgggg tgcagcatcc 1434961 cgctccgttt acggtatccg ctattggaga tccagatgtc ctgctgccct cgttaaatat 1435021 cgctggaggc ctaattgatc agctgtcaat ggatcatatt tctgtgtcgg cagaaaaaga 1435081 gaaaaacgta caaatgaaac cgattctgaa aacgaaggaa tgactgaaaa agcgggtgaa 1435141 atagattgaa aataaagcgt tccttcataa gcatcagtgt tcttatggtc atcttcggcc 1435201 tgatgatatc tgttcagttt aattcgttaa agcaccccaa agtccgggat acaagagata 1435261 tgtgggatat tagggaagag ctgacatcag agcagaagaa gcaggaaaag ctgctggctg 1435321 aaataaacaa atatgacaaa ttgctgaata gctattcgca aacgaaagaa atgacaaaag 1435381 aaaccgcgct aaataatacc ttgcaatcct taaaaaaaac agccggcatg accgatataa 1435441 caggtagcgg aattgtcatt acgatttccc cgcttttttc tgaaagctta acaggagagc 1435501 cgatcgaaaa tccgcctccg gatttgctga aaaagctgat aaatgaactc aactcctacg 1435561 gtgcagagca tatctcgatt aatgagcgaa gagttgtgaa tcatacagtc atcagagata 1435621 taaacggcac tacaaaaata gacggatacg cccttgacga ttatccttta acagtaaaag 1435681 tgcttgccaa agatccggac atgttacaca gcagagtgaa ggggtcaggc cttgaggatc 1435741 tttttgcatc tgaaaattta gcattaaaag ccggtaaatc tgaaagcaaa ctaacattaa 1435801 aagcatatga cagaccactg gacgtacaac agctgaaact gcttaaagac tgaaaaggag 1435861 gagaattgtc atgtggctgc ccgtgttggg actggtgctc ggaatagcga ttggactaat 1435921 gacaaactta acgataccga gtgaatactc aaactattta tcgcttgcgg tgcttgccgc 1435981 acttgataca ttaatcggcg gaatcagggc gcatttacaa ggtacatatg atgaaatggt 1436041 atttgtttcc ggtttctttt ttaatattat attggcaata agtttagctt ttctgggagt 1436101 ccatcttggt gtagacttgt atttagcagg tatattcgca tttggagtca gattatttca 1436161 gaatatagcc gttatcagaa gaaatctact aacaaagtgg actctttcta aaaaaaataa 1436221 aaaaaatgtg atataaaaga ggatatacat aggatataac gaatattttc aataaacata 1436281 aaatgtgaaa agcacataaa aatattctgt tgttattttt tgttacacac ttgtaaagcc 1436341 acattcattg tattgttgtt ccgcaaataa tagaatagaa atgatcgaaa tgtgaggagg 1436401 tgccatagaa tgaacaacaa tgaactttac gtcagtcttg acatcggtac gtccaataca 1436461 aaagtgatcg tcggagaaat gacagatgat tcccttaata ttatcggtgt gggaaatgta 1436521 ccgtctgaag ggttgaaaaa aggctcaatc gttgatatag atgagaccgt tcattctata 1436581 agaaaagcgt ttgaccaagc tgaaagaatg gtaggttttc cgcttagaaa agctattgtc 1436641 ggcgttaatg gaaattatat caatattcaa gatacaaacg gtgttgtagc agtttccagt 1436701 gaaaataaag aaattcaggt tgaagatgta cgccgtgtca tggaggcggc acaggttgtt 1436761 tccgtaccgc atgaacagct gattgttgac gtcattccta aacagtttat cgtagatgga 1436821 agagatgaaa tcaccgaccc gaaaaaaatg ctgggtgtgc gtttagaagt agagggcacc 1436881 ttgatcaccg gttcaaaaac aatcttacat aacttactcc gctgcgttga aagagctggt 1436941 attgaaataa ctgatatttg ccttcagccg ctggcagccg gttctgctgc attatcaaag 1437001 gacgagaaaa accttggtgt ggctctcatt gatatagggg gagggtcaac aaccattgcc 1437061 gtattccaga acggacatct cacttctacc cgtgtcattc ctctcggagg cgaaaatatc 1437121 accaaagata tctccatcgg attgagaacg tcaacagaag aagcagaacg cgtgaaaaag 1437181 caacttggac atgcctacta tgacgaagcc tcggaagatg aaatatttga ggtaaccgtt 1437241 ataggcacca atcaaaaaca aacatttaca cagcaagaag cagcgaatat cattgaagcg 1437301 agagtagagg aaattcttga aattgtttca gaagagcttc gcagtatggg aattaccgat 1437361 ctgccgggag gcttcgtgct gacaggagga caagcagcta tgccgggtgt catgtctttg 1437421 gcacaggatg tgctgcaaaa caatgtcaga gtggcaagcc cgaattatat cggtgtaaga 1437481 gatcctcaat atatgacggg agtgggcctg atccaattcg cctgccggaa tgcaagaatc 1437541 caaggcagaa aaataggctt taagatgcct gaagaagcga tacaggaaat cgcagtctca 1437601 tcatctgagg aacaagagca gcatcatcac caaaatgagg tgcagcagcg gccaaaagga 1437661 aaacaaaaaa cacaagccga acataataaa cagagcaaaa tgaaaaaact attaagcatg 1437721 ttttgggaat agatagatag tcattcggca gattaggagg atttagcatg ttggagttcg 1437781 aaacaaacat agacggctta gcatcaatta aagtaatcgg agtaggaggc ggcggtaaca 1437841 acgccgttaa ccgaatgatt gaaaatgaag tgcaaggagt agagtatatc gcggtaaaca 1437901 cggacgctca agctcttaac ctgtcaaaag cagaagtgaa aatgcaaatc ggcgcaaagc 1437961 tgactagagg attgggagca ggtgcgaatc cggaagtcgg gaaaaaagcc gctgaagaaa 1438021 gcaaagagca gattgaagaa gcacttaaag gtgctgacat ggtattcgtg acagctggta 1438081 tgggcggcgg aacaggaaca ggtgccgcac cggttatcgc acaaatcgcg aaagacttag 1438141 gcgcattaac agtcggcgtt gtgacaagac cgtttacctt cgaaggacgc aaaagacagc 1438201 ttcaggctgc aggcggaatc tcggcaatga aagaagcggt ggatacactg atcgtgatcc 1438261 cgaacgaccg tatccttgaa attgttgata aaaacacacc gatgcttgaa gcattccgcg 1438321 aagcggataa cgtacttcgc caaggggttc aaggtatttc tgacttgatt gctacacctg 1438381 gtcttatcaa ccttgacttt gctgatgtga aaacaatcat gtcaaacaaa ggatctgctt 1438441 tgatgggtat cggtattgct actggggaaa atcgcgcggc agaggcagca aaaaaagcaa 1438501 tttccagccc gcttcttgaa gcggccattg acggtgcgca aggcgtcctc atgaacatca 1438561 ctggaggaac aaacctcagc ctatatgagg ttcaggaagc agcagacatt gtcgcttcgg 1438621 cgtctgatca agacgtaaac atgattttcg gttctgttat taatgaaaat ctaaaagatg 1438681 agattgtggt gacagtgatt gcaaccggct ttatcgaaca agagaaggac gtgacgaagc 1438741 ctcagcgtcc aagcttaaat caaagcatca aaacacacaa tcaaagtgtt ccgaagcgtg 1438801 agccaaaacg tgaggaacct cagcagcaga acacagtaag ccgtcatact tcacagccgg 1438861 ctgatgatac gcttgacatc ccgacattct taagaaaccg taataaacgc ggctaatgta 1438921 aaggacaaaa tcgttttcga ttttgtcctt ttttgttttt ctcttcacac tttccttctt 1438981 ataaagtctt tttccctatt gcttccttcg cgagctcgat tatggatggt ttacgttttg 1439041 gaaaaagtaa ggtatcctag ttcgtacaaa gttttatgaa aattaaaaca attataaaag 1439101 gcaataaaga ggaggaccac gatgattttg cagcttgaca atgtctcact aaaacggaat 1439161 gggaaatgga tactgaaaga tattcattgg aaggtggaag aaaaggaaaa ttgggtgctt 1439221 tacggcctaa atggcgccgg gaagacagcg ctgttaaata tgctttgctc atattatttt 1439281 ccaacatcag gcgagatgca ggtgctcggc catgaatttg gcaaaacaga gcttggggaa 1439341 aagctcagac gtaaaattgg cctcgtctca gcagctcttc agcaaaaatt gtatccggca 1439401 gattcagctt ttgaaattgc tttgagcgga gcttacgctt cgattgggtt atatgaaacg 1439461 ccaagtaagg aaaccaggga aaaagcgata ggtttgttag aggacttggg agcaattgaa 1439521 tatgccgatc gccgctatga aaccctttct caaggggaaa aacaaagagc attgattgct 1439581 agagcactaa tggccgatcc ggagctgctg atactggatg aaccagtcac aggactggat 1439641 tttattgccc gggaaaagct gttagatacg attacataca ttgcaaacaa agaaaatgca 1439701 ccatctatcc tttatgtgac tcatcatgct gaagaaattt tgcctgtctt tgataaagcc 1439761 cttttattaa aacagggaga ggtttttgga tccggagaaa taaaggaaat gcttactgat 1439821 caaatacttt ccgctttttt tgatacgcca atccatgtat tatggaatca ggatcggccg 1439881 tttttaacaa gagctgagcc gataacgaat gcctgacaaa tatatataga ttcatcctag 1439941 gggtgctttg cgaagctgag agagactttg tctcaaccct tttgacctga tctggatcat 1440001 gccagcggag ggaagcggtg aaaagcggag tacatcggac tccgtttgtt tttattaagc 1440061 cgtttcatca catttgaaac ggcttttttg attttaaaga ataggagcgg atttacattg 1440121 gatcaacaaa tatactcttt gcaaaaaaaa gtggaagaac ataaggagga gcttattcag 1440181 cttgcgaaaa cgctgatttc ttatcaaaca cctgctccgc ctgcaagaaa tacagagggc 1440241 attcagtctt ggattgcggg atatttaaat gaattgggat tctcgatcga caaatgggat 1440301 gtgtaccctg gagatcccaa tgttgtaggg aagctaaaag gaacagattc agcagattat 1440361 tatagcctga ttatcaatgg ccatgtagat gtggcagagg taaaagagga tgaagaatgg 1440421 aagcacgatc cgtttcatcc cattgaaaaa aacggtctct taatcgggcg aggcgcttcc 1440481 gatatgaagg gcggaatggc ttgtgtgctg tttgctgtca aattaattcg tgaagcaagc 1440541 attgaacttc caggtgatct gattctgcaa tcggttattg gggaggaagt tggagaggcc 1440601 ggcacacttg aatgctgcaa gaggggctac cacgctgatt ttgcaattgt cgcggatacg 1440661 agcgatatgc atattcaagg ccaaggcggt gtcattacag gctggatcga aatcaaaagc 1440721 agtcaaacat ttcatgatgg aacgagacgg aatatgattc atgcaggcgg aggaacattc 1440781 ggagcaagcg caattgaaaa aatggcaaaa atcattgcgg ggctcggtga acttgagcgc 1440841 cactggtcta ttatgaaaag ttatcccggt tttaaaccag gcacaaatac gattaacccg 1440901 gcagttatag aaggcggcag acatgcggct tttatagcgg acgaatgccg gctgtggatc 1440961 acagtccatt tttatccgaa tgaaacccat gaccaagtgg cagcggaaat agaagattac 1441021 gtcaatcggc tgagtgacag tgatatttgg cttagggaaa accgccctgt attcaagtgg 1441081 ggaggctcat ctatgataga agacagggga gaaatttttc cggcattgga agttgaccct 1441141 ggccacccag gcgtcttagc gctaactgcc tctcatcaga aagtgaaacg ggagtgtcca 1441201 attattgacg tttctcaatc agttacagat ggcggatggc tgtatgatgc cggtattcca 1441261 tgcgtaatat acggtcctgg agatctgcac aatgcacact ctgtgaacga gaaggtatcg 1441321 attgagcagc tagtagagta tacaaaaatt atactcgatt ttatcatcag ctggtgcagc 1441381 cggaaaaaag aacaatgaca tgaaaatttc ttcttgctga caaggttcag cctgcccgtt 1441441 catatacttg aacaaaagga cggaaaaagg acgtgatgga atgatcagca tttcagaatt 1441501 tcaggtaaag gatgtcgtca atgtctcaaa cggaaaaaag ctggggagta ttggtgatat 1441561 tgatatcaat gtgaccactg gaaaaattca ggcgatcata ctcggaggaa atgggaaagt 1441621 tctcggattt tttggaaaag aagaggaatt ggtcattcca tggcgaaata tagtaaaaat 1441681 cggggaagat gtaatcttag tccgattaag tgaaccacat gcataaacct gcttgtctgc 1441741 cgcagattgg caaatgccgg aagtctcgat tcttccggca catttcattt agaaatatgc 1441801 aaatcggcgc tcaacgaatg cagtaagatg tggtaaaata agtgggaaat tccgcttttt 1441861 taaatgtttg tcgaaaggtt ggatcatcat gaatacatat cacccattca gtcttaccac 1441921 accctcgaca ctcatgatac aagactgggc tcaaacgaat caaaacaaca aagaggtcat 1441981 tgccggattt acgacaaaaa acggcggtgt cagccaaaag ccttttgaat cgttaaatac 1442041 aggattgcac gttcatgaca aagatgcaga tgtagttaaa aatcgtgaat atattgccga 1442101 tatgtttaat actgatttgc agtcttgggt attcgctgat cagacacatg ataatcgcgt 1442161 tcagaaagtg acgcagaggg ataggggaaa aggcgcccgt gagtatcaca cggctctaaa 1442221 agcaacggac gggatctata caaatgaaaa aaatgtattt ttagcattat gctttgctga 1442281 ttgtgtgcct cttttctttt atgatccggt taagtcgctt gtcggagtcg cccatgccgg 1442341 gtggaaaggc accgtcaaac agattggcag agaaatggtg aagcaatgga ctgagaagga 1442401 aggttcaaat ccctcagata tttacgctgt tattggcccg tctatcagcg gagcatgcta 1442461 tacggtagac gaccgcgtca tggatgctgt ccgcgcattg ccggtttcag cagaccttgc 1442521 cgccaatcag acggcaaagg cacaatatca gcttgatctg aaagagctga accgtcttat 1442581 actgatggac agcggtttgg caagtgaaca aatttctgtc agcggtttat gcacggaaag 1442641 cgagccgtct cttttctatt ctcatcgccg cgatcagggg aaaactggac ggatgatgtc 1442701 ctttatcgga atgaaggagg cataaaagat cttgcgtgtt gttgataatt tacgacatat 1442761 aaacgaacga ataaacgaag catgtaacag atcgggccgc agctccgatg aagttacggt 1442821 tattgcagtc acaaaatatg tatcacctga aagagcacag gaggcagtag atgctggcat 1442881 cacctgcctc ggagagaatc gggatgcgga actgctccgc aaacaggaat tgatgaaagg 1442941 gaatccggaa tggcatttta tcggcagtct gcaatcaaga aaagcaaaat ctgtcgtcaa 1443001 ttcggtttcc tatatccatt ccctagaccg gctctcatta gcgaaagaaa ttgaaaaacg 1443061 ggctgaaggt actgtacgat gctttgtgca ggtcaatacc tctcttgagc cttctaaaca 1443121 tggcatgaaa aaagaagaag tcattccatt catacaggag ctttccggtt tcgaacatat 1443181 ccttgttgcc gggctgatga caatggctcc gctgactgat gatcaagatc agatcagaag 1443241 ctgtttcagg tcgctgagag aactccgtga ccaggttcag aagctgaacc agccgaacgc 1443301 tccgtgtact gaactgtcga tgggcatgtc aaatgatttt gaaattgcaa ttgaagaagg 1443361 agctacttat attagaatcg gctcatcgtt agtcggaaat gaaacagggg gtgtacagca 1443421 atgagtatga aaaataaact gaaaaacttt ttctcaatgg aagatgaaga atacgaatat 1443481 gaatatattg agacagagcg ggaatctcat gaggagcatg agcaaaaaga aaagccggct 1443541 tacaacggga ataaacctgc gggcaaacag aatgtagtga gcttgcaaag tgttcagaaa 1443601 tcctctaaag tggtgttgag tgagccgcgc gtttatgcgg aggcgcagga aatagccgac 1443661 catttgaaga accggcgggc agttgtcgtc aatcttcagc ggatacagca tgaccaggcg 1443721 aagcggattg ttgacttttt aagcggaacc gtttatgcca ttggcggcga tattcaaaga 1443781 atcggctcag atattttcct ctgcacgcct gacaacgtag atgtatcagg cacaatttct 1443841 gagctcatat ctgaagacga acatcagagg tggtaaagcg agatgatcct ttatcaagtt 1443901 ttttcggttt taagcttatt aatcacaata tactcatttg ccctgatcat atatattttt 1443961 atgtcatggg tgccgagtac gagggaaaca gcagtcgggc gttttttggc ttcgatttgt 1444021 gaaccatatc tcgaaccatt cagaaaaatc atccctccga ttgcaatgct ggatatttca 1444081 ccaatcgtag caatacttgt gcttcggttt gcgacaaccg gcttgtgggg actttatcgc 1444141 atgattgcgt tttaatgtga cagtttgata ggggcttggc agcagccaag cctctttaca 1444201 tagaagggaa agacgatgag cgatatatat cagcacttca gaaaagacga gcgggccttt 1444261 attgatcaag cgctcgaatg gaaaagaatt gtccaggagc agtaccggat gaagctgacc 1444321 gactttttag atccccgaga gcaggtcatc ctctctgctg ttacgggaca ggcagatgtc 1444381 gggcttgcct tttccggcgg ctatgacaga gcggagcgga aacgggcgat tctgtttcca 1444441 gagtacatta ctccggaaga atcagatttt gaactgcagg cgtttaacgt ccgttatgct 1444501 gacaagtttg tctcagtaga tcatcgttct ctgcttggtg cattaatggg cataggatta 1444561 aagcggcaaa aattcggtga catcgtgttt tctgagacag cagtgcaatt gattgtctca 1444621 gccgataccg ctgattttgt ggctgcacag ctgacccaag caggcaaagc ggcggtcagc 1444681 ctagagaaaa tcgacttgtc agaccttaac attccagcag ttgatgtcga aataagagat 1444741 gacacggttt cttctttaag gcttgacgcc gtctgcgcct ctatgagcag gcaatcccgc 1444801 cagaaatcac agacgcttgt gaaaaacggc cttgtgaaag tgaactggaa ggtggttgaa 1444861 gatccttcat acatagtcgc ggaaggggac atgctgtcta tcagaggttt tggccggtgc 1444921 agcttaacaa aaatcgaagg aaaaaccaaa aaagacaaat ggagagttac gtttgaacga 1444981 caaaaatagt cggtttttca gtttttttct ccatctgtgc gaaatttgtt ttataatgtg 1445041 aactagataa ccgtactgaa atgtaaaaat ggaggtggca tcatgccatt aacgccaaat 1445101 gatattcaca acaagacgtt tacaaaaagt tttcgcggat atgatgaaga tgaagtaaat 1445161 gaattcctag cccaagtcag aaaagattac gaaattgttc tccgcaagaa aactgagctt 1445221 gaagcgaaag tcaatgagct tgatgaaaga atcggacact ttgccaatat tgaggagaca 1445281 ttgaataaat caattttagt tgctcaagaa gcggctgaag acgtaaaacg caattctcaa 1445341 aaagaagcaa agctgatcgt tcgggaagcg gagaaaaacg ctgatcgcat tatcaacgaa 1445401 tcgttatcaa aatcaagaaa aattgcaatg gaaattgaag agctgaaaaa acagtctaaa 1445461 gtgttcagaa cacgtttcca aatgctgatt gaagctcagc ttgatcttct gaaaaatgac 1445521 gattgggatc atctccttga gtatgaagtc gacgctgtat ttgaggaaaa ggaataaatt 1445581 ctctgattat cttgacattt tcttagcttg tcgaatataa tacgttcata aattcagatg 1445641 aaaaaacggt tgaaagggac agtcatgttt ccttcaggcc ttcatagcga cccggagatg 1445701 gtgagagtcc gggatggccg gaatcatgta gatcagccct ttagtttcct tgctgaactc 1445761 acagtaggtt aggacgttca tcacgttacg atgctcaaga ggaaaaagtg tatgcttgct 1445821 ttttctaaaa gggtggtacc gcgagataag ctttctcgtc ccttatggga tgagagggct 1445881 ttttttattt tctgaaaaaa tgcagtggag gaatgaaaat ggattttaaa gacacgctct 1445941 taatgccgaa aacagatttc ccgatgcgtg gaaatttgcc aaaccgtgag cctgacattc 1446001 aaaaaaaatg ggaggaagaa gatatctacc gtcttgttca ggaacggacg aaagaccgcc 1446061 cgaaatttgt tttacatgac ggacctccgt atgcaaacgg cgacatccat atgggccatg 1446121 cacttaacaa gattttgaaa gacttcattg tccgctataa atcaatgagc ggctacaacg 1446181 caccgtatgt gccgggctgg gatacacacg gattgccaat tgaaacagct ctgacaaaaa 1446241 acaaaaaggt caaccgcaaa gaaatgtcag tagcggaatt ccgcaaacta tgcgaagagt 1446301 acgcttggaa gcaaatcgag ggacagcgtg agcaattcaa acgtcttggt gtccgcggtg 1446361 actgggaaaa cccatatgtg acattaaaac cggaatacga agcgcagcaa atccgcgtat 1446421 ttggtgaaat ggcaaaacga ggctacattt acaaaggcct taaaccggtt aactggtcac 1446481 cttcaagtga gtctgctctg gctgaagccg agatcgaata tcaagataaa cgttcagcat 1446541 ctatttacgt cgcttttggt gtaaaagacg gaaaaggcgt tcttgaaaac ggcgagcgca 1446601 tcatcatttg gacaacaacg ccgtggacaa ttccggcgaa cctcggaatc tcagtgcacc 1446661 ctgatcttga gtacagcgtg attgcagtag gtgaagaccg ctttgttgta gcaagtgcct 1446721 tagtcgaaaa tgttgcatcg gcatgcggat ttgatcagta tgaagtgaca agaacggtca 1446781 aagggaaaga ccttgagaac attatcgctg aacacccgct atatggcaga gactctctcg 1446841 ttatgcttgg tgaacacgta acaactgatg ccggaacagg ctgtgttcat acagcgcctg 1446901 gacatgggga agatgacttt atcatcggcc aaaaatacgg tttagatgtg ctttgcccgg 1446961 tcgatgaaaa aggtgtaatg acaagcgaag ctcctggctt tgaaggcatg ttctatgatg 1447021 atgcaaacaa agcgatcaca cagcagcttg atgaaaaagg cgcacttgtg aagcttgaat 1447081 tcattactca ttcttatccg catgattgga gaacaaaaaa accaaccatt ttcagagcaa 1447141 cagcgcaatg gtttgcgtct attaaagatt tcagatcaga cctgctggat gccattaaag 1447201 aaaccaaatg ggttcctgaa tggggcgagc agcgtttgca caacatggtt cgggaccgcg 1447261 gagactggtg tatttccaga cagcgtgcgt ggggtgtgcc gattccggta ttttacgctg 1447321 aaaacggaga accggttatt acagatgaaa ccattgaaca tgtttctgaa ttgttcagac 1447381 agcatggatc aaacatttgg tttgaaaaag aagcaaagga tcttcttccg gaaggcttta 1447441 cgcatcctgg cagcccgaac ggcacattta caaaagaaca ggatatcatg gatgtttggt 1447501 ttgattcagg ctcttcacat caagcagtgc ttgaagaacg tgatgacctc gttcgcccgg 1447561 ctgatctata cctagaggga tctgaccaat atcgcggctg gtttaactct tctctttcta 1447621 cagcagtagc cgtaacaggg aaagcgccgt ataaaggtgt gctcagccat gggttcgcac 1447681 tggatggaga aggacgtaag atgagtaaat caatcggtaa cgttgttgtt ccggctaaag 1447741 tcatgaaaca gcttggtgcc gacatcttaa gattatgggt atcttcagtg gattatcagg 1447801 cggacgttcg cgtgtctgac gccattctga agcaggttgc ggaagtatat cgtaaaatcc 1447861 gcaacacgtt ccgtttcctt cacggcaacc ttttcgattt tgatccaaaa acaaatgcgg 1447921 tggctgtcga agatcttcgc gaagtggatc agtatatgct gattaagctg aacaagctga 1447981 ttgataaagt gaaaaaagcg tatgatgagt acgaatttgc ggttgtgtat cacagcattc 1448041 ataatttctg cacaatcgaa ttgagctcat tctaccttga ttttgcaaaa gatattgtct 1448101 acatcgagca tgcggatcat ccggatagac gcagcatgca gacagtattc tacgaaacgc 1448161 ttcttgcatt agtgaagctt tcagcgccta tccttccaca tacggcagac gaattgtggt 1448221 ctcatttaac atttgttgaa gagcagagcg ttcagttgac cgatatgccg gaaacaatca 1448281 cggttccaaa cagtgaagcg actgaagaaa aatttgaccg ctttatggct cttcgtgatg 1448341 acgtgttaaa agcattagaa actgcgcgaa atgaaaaaat tatcggtaaa tctttggaag 1448401 caaacctgaa attgtatcca aacaaagaaa acaaggagct cttggcttcc ataaaagaaa 1448461 acctttctca gctgtttatt gtgtctgaac tgacaatcag cgaagaaaat gaagcgccga 1448521 acgatgcgca aagctttgcg acgggtaaaa tcgctgtcga gaaagcggaa ggcgaaatgt 1448581 gtgagagatc tcgtgtgatt tcaaaagatg taggggcaaa tccgaaatat cctacacttt 1448641 cattacgcaa cgctgaaatc gttgaaaaat actatcaaaa ataatgcaaa agagcccggc 1448701 gtaaaagccg ggcttttttt gtgccaagag tgacatcctt tagaacgaaa ggaaaaatct 1448761 tatgggcttt agatcatcat tcacaggcaa caataaagat actacgttaa gagcaggagt 1448821 tgtgaagaat gaatgatcaa ctgaccgcaa tttatacgga acttcttctg atgaaagaag 1448881 aattacagtc gagattattt gagtattctt gctttcaggt ttctacaagc ccgcaagcag 1448941 caatcaatca aaaacaaaaa gcaactctga tctatcatat taaagaagaa cttcaagacg 1449001 ttctccttgc attgtccaaa atcgaaaacg gcacattcgg atactgtgaa gaaactgggg 1449061 cccccattcc tcttgcaaag ctggcagtgc tgccgacggc ccgaacagca aacgattttc 1449121 tttattctgt ccaatttgag aaaaaaacgc ttccgatatg gaaatcaacg gatatcgaat 1449181 atggtcaggc actgtatgaa taacagtgtc tgtccggtta atatgcctga tatttcttta 1449241 ctccagtgct ttttattgat aaaatgcata atggattaaa gtaaccgtaa actggaggaa 1449301 cgtttgtgct gtattatatg attgcactac ttattattgc agccgatcaa ttgacaaaat 1449361 ggctagttgt taagaacatg gaacttggcc aaagcattcc gatcattgat caggtattct 1449421 atatcacctc ccatcgcaat acgggtgctg catgggggat attagcgggt caaatgtggt 1449481 ttttctacct cataacaacc gctgttatta ttggtattgt ttattacata cagcgttata 1449541 caaagggaca aaggcttctt ggcgttgccc tcggacttat gcttggcggt gccatcggca 1449601 actttatcga tcgggctgtc agacaggaag ttgtggattt tatccatgtt attattgtca 1449661 attacaatta cccgatattt aacatcgcgg actcttcact atgtgtcggc gtaatgcttt 1449721 tatttataca aatgctgttg gacagcggga aaaagaaaaa ggagcaatag catgaatcaa 1449781 attgatataa ccgcttcaga agaacaaaaa agtgagcgga ttgataaatt tttggcatcg 1449841 actgagaatg attggtcaag aacccaggtt cagcaatggg taaaagacgg acaggttgtc 1449901 gtgaacggaa gcgcggtgaa agcgaattat aaaattcagc cgggtgatca ggtgaccgtc 1449961 actgtacctg aaccggaagc gctcgacgtc ctggcagagc ctatggatct ggatatttat 1450021 tatgaggacc aggatgtgct ggtcgtcaac aaacctcgcg gaatggttgt tcacccagca 1450081 cccgggcatc ttacgggcac acttgtaaac ggtcttatgg ctcattgcac agacctttcc 1450141 ggaataaatg gtgtgatgcg cccgggtatt gttcacagaa tcgataagga cacgtccggt 1450201 ttattaatgg tggcgaaaaa tgatatggcg cacgagtcac tcgtaaacca attggtcaac 1450261 aaaacggtca cgcggaaata tacggcggtt gtccacgggc ttatttctca tgatgacggc 1450321 acaattgacg cgccgatcgg acgggataaa aaagaccgtc aaagcatgac tgtgacacgt 1450381 gatggcaaaa acgctgtcac tcattttcat gtgcttgagc gttttcagga ttttacgtta 1450441 gtggagtgcc agcttgaaac agggagaacc catcaaattc gtgttcatat gaaatatatc 1450501 ggattcccat tagcaggcga tccgaaatac ggcccaagaa aaacaatcga ctttaatggc 1450561 caagcgcttc acgcgggagt tttaggtttt gaccatccac gaacaggaga atatgtcgaa 1450621 tttgaagcgc cgcttcccga ggatatggca gaattaatcg aaaacctcag aaaaaacggt 1450681 tgacagaggg tttcttttct gaaataataa acgaagctga atagattctt taaaacagtc 1450741 cagagaggct gagaaggata acggatagac gggatgcgtg tataggcgcg caccttgtcc 1450801 taaaacccct ctatgctctg gcaggagggg ttttttcttc tatatgaact gtgaggtgtc 1450861 acacattgaa tcaaaaagct gtcattctcg acgaacaggc aattagacgg gcgctgacca 1450921 ggattgctca cgaaatgatc gaacgcaata aaggaatgaa taactgcatt cttgtcggca 1450981 ttaagacaag agggatttac ctggcaaaac gccttgcgga acgcattgaa cagattgagg 1451041 gaaatcctgt tacagtcggt gaaattgata ttactcttta cagagatgat ctttctaaaa 1451101 aaacaagcaa cgatgaaccg cttgtaaaag gtgcagatat tccggtagat attacagatc 1451161 aaaaagtcat tctcgttgat gatgttctgt ataccggaag aacagtcaga gcaggaatgg 1451221 atgcgcttgt tgatgtaggc agaccttcct ccattcagct tgcagtgctt gtggacagag 1451281 gacaccggga gctgccgatc cgagcggatt atatcgggaa aaacatcccg acatcaaagt 1451341 ctgaaaaggt tatggtacag cttgatgagg tagaccaaaa cgatctcgtc gccatttatg 1451401 aaaacgaata atagatcacc tttttaaggg caatccagag aggttgcaaa gaggtgcaca 1451461 acaaaggccc aaaaagtatt cggcaggtct ttgtatgcct ctttgcgtaa aaaagcaaag 1451521 aggttttttt atacagtcat tgagtcatcc taaaatgaaa gtcaacaatc agggggaaat 1451581 catcatgagt aagaaaaaag taaatttagg ggtcagggat gtcccgacac ctttctcttg 1451641 ggtttcattc agccttcagc atttgtttgc catgtttggc tcaaccattt tggttccgaa 1451701 gctcgtcgga atgagtcctg ctgtggcgtt ggtgacaagc ggcatcggaa cactggcgta 1451761 ccttcttatt accaaaggac aaattccggc gtatctcggt tcatccttcg cctttatttc 1451821 tccgatcatt ctggtaaaag cgaccggcgg gccgggagcg gcaatggttg gagcgtttct 1451881 tgcagggctg gtgtacgggc tgattgcctt attgattagg cagcttggaa caggatggct 1451941 gatgaagatt ctcccgcctg tagtcgtagg gcctgttatt atcgtcatcg ggctgggact 1452001 ggcaagcact gcagtaaaca tggcgatgta tgctgatccg aacgcgagtg agttggtcta 1452061 cagcttaaag cactttagtg tcgcaggagt tacgctggca attacgatta tttgtgcgat 1452121 tttcttacga gggtttttaa gcctgattcc ggttctgatc ggaatcatcg gcggatacct 1452181 gtttgccctt actcaaggga ttgtcaactt ccagccggtg cttgacgcga aatggtttgc 1452241 agtgcctgaa tttatcattc cgttcaaaga ttattcaccg tcagttacgc tcggcatcgc 1452301 agccgcaatg gttcctgtcg catttgtcac aatgtcagag catatcggcc accaaatggt 1452361 gctgagcaag gttgtcggac aagacttcat taaaaagcca ggtcttcatc gctctattat 1452421 gggtgacagt gtggcgacaa tcctcgcttc cctgatcggc ggccctccga caacgactta 1452481 cggagaaaac attggcgtgc tggccatcac aagagtattc agcgtctttg tcatcggggg 1452541 cgcggcagtg attgcccttt gcttcggctt tatcggcaaa atttcagcgc tgatcagttc 1452601 agtgccgtca gcggtcatgg gaggcgtctc cttcctgctg ttcggaatca ttgcttcaag 1452661 cggcctgaga atgctgattg acaacaaaat tgattatgaa aacaacagaa acctcattat 1452721 tacatcagtt atccttgtca tcggtgtagg aggcgctttt atccaagtgt ctcagggcgg 1452781 attccaagtg tcaggaatgg cgcttgccgc aattgtcggt gtcatcttaa acctgattct 1452841 tccgcaggcg aaggaagagc aggcagacac atctgaacaa catcatattt aaaacctttt 1452901 aatgaaagtc cagagaggct tggaagggtt atgaagagaa ggaagcttca atgctgccct 1452961 ctatttaacc ataccccgag tctatcttag accggggttt tttttcagcc ttaagttgaa 1453021 aagagagggg aaagaacatg aagcatttaa cgacgatgag tgaacttagc actgaggaaa 1453081 tcaaagattt gcttcaaaca gcacaagagc tcaaaagcgg aaaaacagac aatcagctta 1453141 caggaaagtt tgcagcaaac ctgtttttcg aaccgagcac gagaacgcgg ttcagctttg 1453201 aggtcgcaga aaaaaagctg ggcatgaatg tgcttaacct tgatggaaca agcacaagcg 1453261 tgcaaaaagg cgaaacctta tatgacacga tccggacgct tgaatcaatc ggtgtggacg 1453321 tctgcgtcat caggcacagt gaggatgagt attatgaaga gcttgtcagc caggtgaaca 1453381 ttccgattct gaatgcggga gacgggtgcg gccagcatcc aacacaatca ctgcttgatt 1453441 taatgacgat ttatgaagag ttcaatacgt ttaaagggct taccgtctcc attcacggcg 1453501 acatcaagca tagcagagtg gcaaggtcaa atgcggaagt gttgacaaga ttgggtgccc 1453561 gggtcctatt ttccggccct tcggaatggc aggatgaaga aaatacattc ggcacgtatg 1453621 tctcaatgga tgaagcagtt gagtcttccg atgttgtcat gctgctgcgc attcaaaatg 1453681 aacgacatca gtccgctgtc agtcaggaag gctatttaaa caaatacggc ttgaccgtag 1453741 aacgggctga gcgtatgaag cggcatgcga tcatcatgca tcctgctccg gtaaacagag 1453801 gagtggagat tgatgacagc ttagtagaaa gcgaaaaatc aagaatcttc aagcaaatga 1453861 aaaatggcgt atttatcaga atggcagtga tacagcgtgc cttacaaacc aatgtgaaaa 1453921 gaggagaagc agcgtatgtc atatctcatt aaaaacggct ggatactaaa cgaaaatggt 1453981 gaaaaaacac aagcggatat ccgagtgact ggagaaacca tcaccgcaat cggcaagctt 1454041 gatgcaacgg ataatgaaac ggtaattgat gcaaaaggtt tgctcgtttc acctgggttt 1454101 gttgatctcc acgtgcattt cagagagccg ggcggagaga aaaaagaaac tattgaaacc 1454161 ggggcaaaag cagcggcgcg cggcggctat actacagtag cagcaatgcc gaatacgcgg 1454221 ccggttcctg atacaaagga gcagatggaa tgggtgcaaa acagaattaa agaaacatca 1454281 tgcgtaagag ttcttccata tgcatccatt acgatcagac aaatcggcga tgaaatgaca 1454341 aactttgaag cgttaaaaga agccggggca tttgctttta cagatgacgg cgttggtata 1454401 cagacagcag gaatgatgta tgaagcgatg aaacgggcag ccgcaattga caaagcgatt 1454461 gttgcacatt gcgaggacaa ctccttaatt tacggaggga gcgtacatga ggggacattc 1454521 tccaaagcga acgggctaaa cggcattcct tctgtgtgtg aatcggttca tattgctcgc 1454581 gatgtgctgc tggctgaggc ggcaaactgc cattatcatg tatgccatat cagcacaaaa 1454641 gaatctgtca gagttgtacg cgatgcgaaa aaagcgggaa tcagagtgac agcagaagta 1454701 tcgccgcatc atttgctgct ttgtgatgag gacatcccgg ggctggacac aaactataaa 1454761 atgaatcctc cgctccgcag cccagaagac agagctgctt taattgaagg tcttttagac 1454821 ggaacaattg attttatcgc aacagaccat gcaccgcata cggaagaaga gaagaacaca 1454881 gaaatgaagc tggcgccatt cggaattgtc ggcttagaaa cagcattccc gcttctttac 1454941 acacactttg tcaaaaatgg cagctggtca ctgaagcagc tgattgacta catgacaatc 1455001 aagccatgcg aagcgttcgg tctcccatat ggaacattac aaacggggca agctgcggac 1455061 attacgttaa tcgatttaga aaaagaagca gttatagaca aagagacatt tttatcaaaa 1455121 ggaaaaaata caccattcaa cggcatcagt tgcaccggct ggccggtcgc tacaattgcg 1455181 gcagggaagc ttgcttatga agaggggaga cttgtcaaat gaagagacga ttagtactgg 1455241 aaaacggagc ggtattcgag ggagaagctt tcggaagctt agaacacaac atgggagaag 1455301 tcgtttttaa tactgggatg acaggctatc aggaaatttt atctgatcct tcttactgcg 1455361 gacagatcgt aacattaaca tacccgctta tcggaaatta cggcattaac cgtgatgatt 1455421 ttgaatccat tacccctttt gtcaaagggc tgatcatcaa agaattatgt gagctgcctt 1455481 ccaactggcg ttcagcatac accttagacg agtatttaaa aatgaaaaac attcccggac 1455541 tccagggaat tgatacaagg aagctgacaa gaatgatccg cacggcaggc gcgctaaaag 1455601 gaacattcgc ttcatctgat gaagatatcg aagcagtgct gaaaagactg aacgaaacgg 1455661 aattgccaag aaatcaagta tcccaagtat cagcaaaaac agcatatccg agcccgggaa 1455721 gaggcaaacg cattgtcttg gttgacttcg gcatgaaaca cgggattcta agagagctga 1455781 acaaacggaa atgtgacgtc atcgttgtgc cttacaacat tacagcggaa gaggtgcttc 1455841 agctgaaacc ggacggtatc atgctttcta acggacctgg agacccgaag gatgtgcctg 1455901 aagcgattga aatgattaaa ggtgttcttg gaaaagtgcc attattcgga atatgtctcg 1455961 gccaccaatt attcgcgctg gcgtgcgggg cgaatactga aaaaatgaaa ttcggccaca 1456021 ggggctcaaa ccacccggta aaagagctgg ctacaggaaa agttgcctta acatctcaaa 1456081 accatggata tacagtttcg tctatcagta aaacagaact ggaagtgacg catatcgcaa 1456141 ttaacgacga tacgattgaa gggctgaagc ataaaacatt gccggcattt acggttcaat 1456201 atcatcccga agcctcacct ggtcctgagg atgccaacca tctatttgac agattcatcg 1456261 aaatgatcga aacaacagag aaagaagggg aagcggtatg ccaaaacgcg tagacattaa 1456321 caaaatttta gtaatcggat ctggaccgat catcatcggc caagcagcag aatttgacta 1456381 tgcgggaaca caagcctgtc ttgctttgaa agaagaaggc tatgaagtca tccttgtcaa 1456441 ctcaaaccct gcaacgatca tgacagatac agaaatggct gaccgggttt acatcgaacc 1456501 gctcacacct gaattcctga cacgaatcat cagaaaagag cgcccggatg ccattcttcc 1456561 tacactcgga ggccaaaccg gtttgaatct tgcggttgag ctttctgaaa gaggcgtttt 1456621 ggcagaatgc ggcgtcgaag tgcttggcac gaaactgtct gcgattcagc aagctgaaga 1456681 ccgtgacttg ttcagaacat taatgaatga actgaatgaa ccggtgcctg aaagtgagat 1456741 tatccactcc cttgaagaag cagaaaaatt cgtcagtcaa attggattcc ctgtcattgt 1456801 ccgcccggca tatacattag gcggaacagg cggaggcatc tgctcgaatg aaacagagct 1456861 aaaagaaatc gttgagaacg gcttgaaatt aagcccggta caccaatgtc tgcttgaaaa 1456921 aagcatcgcc ggctataaag aaatcgagta tgaagtcatg agagacagcc aggatcacgc 1456981 cattgtcgtt tgtaacatgg aaaacattga tccagttgga atccatactg gagacagtat 1457041 tgttgtcgcg ccgagccaaa cgctcagcga tcgcgaatat cagctcttgc ggaatgtatc 1457101 gttaaaactg attcgcgcgc ttgggatcga aggcggatgt aatgtccagc tcgccttaga 1457161 tccagacagc ttccaatatt acattattga agtaaatccg cgtgtcagcc gttcatctgc 1457221 ccttgcatca aaagcaacgg ggtacccgat tgcaaagctc gctgctaaaa ttgcagtcgg 1457281 actttcatta gatgaaatga tgaacccggt gacaggaaaa acatatgcag catttgaacc 1457341 tgctcttgac tatgtcgtat ccaaaattcc gcgctggccg tttgataagt ttgaatcagc 1457401 aaacagaaag cttggcacgc aaatgaaagc gacaggtgag gtcatggcaa tcggccgcac 1457461 gcttgaagag tcattgctga aggcagtgcg atcactggaa gcggatgtgt atcatcttga 1457521 attgaaggac gccgctgaca tttcagatga gcttcttgaa aagcgaatta aaaaggccgg 1457581 tgatgaacgc ttattctact tagctgaagc gtacagaaga ggctacacgg tagaagacct 1457641 ccatgaattt tccgctatcg atgtcttctt cttgcataag ctgttcggaa tcgtacagtt 1457701 tgaaaaagaa ttgaaggcca atgcgggcga tacagatgtg ctgagacggg caaaagaact 1457761 cggcttctct gatcagtaca tcagccgtga atggaaaatg aaagaatctg agctttacag 1457821 cttgagaaaa caagcgggga ttgcgccggt attcaaaatg gtagatacat gcgcggcgga 1457881 atttgagtca gaaacgccat acttctatag cacatatgaa gaagaaaatg aatctgtcgt 1457941 tacagataag aaaagtgtga tggtgcttgg ttcgggtccg attcgaatcg gtcagggtgt 1458001 cgagttcgac tatgcgacgg ttcactctgt atgggcaatt aaacaagcag gctatgaagc 1458061 cattattgtc aacaacaacc cggaaaccgt ttcaacagac ttcagcatct cagacaagct 1458121 gtattttgaa ccgcttacga ttgaagatgt catgcacatc attgacctcg aacagccaat 1458181 gggcgttgtc gtacaatttg gcggacaaac tgcgattaac cttgctgacg agctttctgc 1458241 acgcggagtg aaaatccttg gaacttcatt agaagattta gaccgtgccg aagaccggga 1458301 taaatttgaa caagcgcttg gagaacttgg tgttcctcag ccgcttggca aaacagcgac 1458361 atcagttaat caggcggtaa gcatcgcaag tgatatcggt tatccggtac tggtacgccc 1458421 ttcctatgta cttggcggcc gggcgatgga gattgtttac catgaagagg aactgcttca 1458481 ttacatgaaa aatgcagtca aaatcaatcc acagcaccct gtattaattg atagatactt 1458541 gaccggaaaa gaaattgaag tcgatgcagt atccgacggt gaaacagtcg tcattccggg 1458601 aattatggag cacattgaac gtgcgggcgt tcactccgga gactcaatcg ctgtttatcc 1458661 gcctcagtct ctcacagagg acattaagaa aaaaattgaa caatacacga tcgcattggc 1458721 taaagggctg aatattgtcg gtttgctcaa tattcaattc gtcttgtcgc aaggcgaggt 1458781 gtacgtgcta gaagtgaatc cgagatcaag cagaaccgta ccgtttttaa gcaaaattac 1458841 gggtatccca atggcgaatc tcgcaacaaa aatcattctt ggtcaaaagc tggctgcgtt 1458901 tggctataca gagggccttc agcctgaaca gcaaggtgta tttgtaaaag cgccggtctt 1458961 ctcctttgcc aagctgagaa gagtggatat tacgttaggg cctgaaatga aatcaacagg 1459021 tgaagtcatg gggaaagatt cgacacttga aaaggcgctc tacaaagcct tgatcgcttc 1459081 aggtattcaa atcccgaact acggttccgt gcttttaaca gtagctgata aggacaaaga 1459141 agaagggctt gccattgcta agcggttcca cgcgatcggc tacaacattt tagcgacgga 1459201 aggaacggca ggctacctga aagaagcttc cattccagcg aaggtcgtcg gaaaaatcgg 1459261 tcaggatggc ccgaacttgc ttgatgtcat cagaaacgga gaagcgcagt ttgtcatcaa 1459321 tacgctgaca aaaggaaagc agccggcaag agacggtttt agaatcagac gtgaatcagt 1459381 agaaaatggt gttgcctgcc taacatcttt agatacggca gaggcgatat tgcgagtgct 1459441 ggaaagcatg acattccgtg ctgatcaaat gccggcagtc aacacaaatc aggaggcggc 1459501 agtcactata tgaaaaaagc gtatttgaca gtatgttcta accagcaaat tgcagaccgg 1459561 gtgtttcaaa tggttctgaa aggggagctt gtccaagggt ttacaacccc tggacagttc 1459621 cttcatctta aagtgagcga agcggttacg cctcttttga gaaggccgat cagcatcgca 1459681 gacgtcaact ttgaaaaaaa tgaagtcacc atcatttatc gggtagatgg ggaagggaca 1459741 agactcttgt cactgaagca gcagggagaa cttgtggatg tcctcgggcc tttgggaaat 1459801 ggctttcctg ttaatgaagt tcaacccgga aagacggctt tgctggtagg aggcggagta 1459861 ggtgtgccgc ctctccaaga gctgtcgaaa cgcttgattg aaaaaggggt aaatgtcatc 1459921 cacgttttag gattccaatc ggcaaaggat gttttttacg aggaagaatg ccggcagtac 1459981 ggagacacgt atgtggcaac agctgacgga agctacgggg aaaccggatt tgtcacagat 1460041 gtgattaaac ggaaaaagct agagtttgat atcctcctca gctgcgggcc gacaccgatg 1460101 ctcaaggcgt taaaacagga atatgcccat aaagaagtat atctgtccat ggaggaacga 1460161 atgggctgcg gaatcggcgc atgcttcgcg tgtgtgtgcc atacaaacga aagtgagaca 1460221 tcctatgtaa aagtatgtct cgacgggcct gtatttaaag ctcaggaggt ggcgctgtaa 1460281 tgctagaggt gaaattgccg ggacttgatt tgaaaaaccc aatcattcct gcatcaggct 1460341 gcttcggttt tggaaaagaa ttttcacgtt tttatgattt gtcttgtctt ggagctatca 1460401 tgattaaggc tacgacaaag gagccgcgct ttgggaatcc gacgccgcgg gtagctgaga 1460461 ctggtgctgg aatgctcaat gcgatcggtc tccaaaatcc ggggctggat agtgtgttgc 1460521 atcatgagct gccgtggctt gagcagtttg atacaccgat cattgccaat gtcgcaggtt 1460581 ctcaagtcga tgattatgtt gaagtcgcag aacatatcag caaagcgcct aatgttcatg 1460641 ctcttgaatt gaatatttcc tgcccgaatg tgaaaacagg cggaatcgct tttggcacga 1460701 atcctgaaat ggctgccgat ttgacaaaag cggtgaaaga ggtttcggat gtacccgttt 1460761 atgtgaagct atccccgaac gtggctaata tcacagaaat tgcattagcg atcgaggaag 1460821 cgggagcgga cggtcttacg atgatcaaca cactaatcgg catgagactc gatttaaaaa 1460881 ccggcaaacc gatattagcg aataaaacag ggggactttc gggccctgct gtgaagccgg 1460941 ttgccattcg catggtgtat gaagtcagcc agatggtcaa catcccgatt atcggaatgg 1461001 gaggcgtgca aacggctgaa gatgccctgg aatttcttct cgcgggagca agcgcagtcg 1461061 ctgtcggaac agcaaacttt gtgaatcctt ttgcatgtcc agagattatt gaacagctcc 1461121 catctgtttt gctccaatac ggctatcaat caattgaaga atgcatcgga aggagctgga 1461181 atcatgaaaa acaacctgcc catcatcgcg cttgattttg cgtcagctga agaaacactt 1461241 gcgttcttag cgccttttca gcaagaaccg ttatttgtaa aggttgggat ggagcttttt 1461301 tatcaagaag ggccatctat cgtgaaacaa ctaaaagaaa gaaactgcga gctattttta 1461361 gatctaaagc ttcatgacat cccgactact gtaaacaaag cgatgaagcg ccttgccagt 1461421 cttggagtag acctcgtcaa tgttcatgct gccgggggca aaaaaatgat gcaggcagct 1461481 ctcgaaggct tagaagaagg tacgccggct ggaaaaaaac gtccgtcact tatcgcggta 1461541 acccagctga caagcacatc tgaacaaatc atgaaagatg aactgctgat cgaaaagtct 1461601 ctgattgata cggttgtgca ctacagcaaa caggcggaag aaagcggact ggatggagtg 1461661 gtctgctctg ttcatgaagc aaaagccatt taccaagcgg tgtcgccttc atttctgact 1461721 gtcactccgg ggatcagaat gtcagaggac gctgcgaatg accaagttcg cgtagcgacg 1461781 cctgccattg caagagagaa aggttcatca gcgattgtag taggacgctc gattacaaaa 1461841 gcggaagacc cggtaaaagc ctataaggct gtcagacttg aatgggaggg aatcaaatct 1461901 tgaaacaaat catcgcaaaa catctattag acatccaagc tgtattttta cgcccgaacg 1461961 agccgttcac atgggcaagc ggcattttat caccgatcta ctgtgacaac cgccttacgc 1462021 tatctttccc agaggtcaga aacgatgttg cttcaggtat cagcaagctt gttaaagagc 1462081 attttcctga agctgaaatg attgcgggaa cagcaactgc cggtattcct catgctgctc 1462141 ttgcggcgga ccatttgaat cttccgatgt gttatgtgag gagcaagccg aaggcgcacg 1462201 gaaaaggcaa tcagattgag ggagctgtgc aagaagggca aaaaacagtc gtcattgaag 1462261 acttaatttc cacaggaggc agcgtgcttg aagcttgtgc agctttacaa gcggccggct 1462321 gtgaagtgct tggtgtcgtc tcaatcttta cgtacggact tcctaaagcg gaggaagcct 1462381 tcgcaaaggc agaactgcca tactactcat taaccgatta tgatacgctc acagaggtcg 1462441 cgcttgaaaa cggaaatatt cattcagatg atctaaaaaa gctgcaaaca tggaaacgaa 1462501 atcccgagtc aaaagattgg tttaaaaaat aaaaaataaa ttcaaatgat gtaaagaggc 1462561 ttcaaagcct tgctgtactt gaaaacaggc tgtgaggcct gtttttttat taatcctata 1462621 aaaaaagtcg ggttgactta tgttagaatt gtgctaaaat ttactacaaa tctaaaaact 1462681 tatcaagagc ggctgaggga ctggacctat gaagcccggc aacctgcata gtttgtaagg 1462741 tgctacttcc agcaaaatga attccatttt gaaagataag ggctgcatgc tgttcctgtc 1462801 tttctttccg ccggattgaa agttttttat tttaagaggt aaaaaggcta tctgtatatc 1462861 agcagccgcg aatcacatta catgggaaaa gacaaccggc agaaagctac tgtttgtttg 1462921 tctccgaaag gaggaaagaa gaaatgttaa cgtatgataa ttgggaagaa ccaacgatta 1462981 catttccgga agacgatcct tataaaggag cgctgtcagt tttaaaatgg gcatacggcc 1463041 attacggcga tcagcttgtt tatgcctgca gtttcggaat tgagggaatc gttctgattg 1463101 acttaattta taaagtgaaa aaagacgcag agattgtgtt tcttgataca ggacttcatt 1463161 ttaaagaaac ctatgaaaca attgaacgag tgaaagagcg ttatccgggt cttaatatca 1463221 tcctgaaaaa accagatctc acccttgagg aacaagccga agaacatggt gacaaactat 1463281 gggaaagaga gccgaatcag tgctgctatc ttagaaaggt cgttccttta agagaggcgc 1463341 tttcaggaca tccagcctgg ctttccggcc tgcgccgtga tcaagggcca agccgtgcca 1463401 atacgaattt cttaaacaaa gatgaaaaat tcaagtcagt aaaagtttgc ccgcttatcc 1463461 attggacttg gaaagacatt tggagatata catcccggaa tgaactggac tacaatccgc 1463521 ttcatgacca aggctatcca agtattggct gtgcgccttg cacttctccc gcttttacag 1463581 cagaagattt gcgctcaggc agatggaatg gtatggcgaa aacagaatgc ggactgcatg 1463641 aataaggagc tgcaaaatgg aattagccgc tattttattt agcttgtttt tcgcgatgaa 1463701 tattggtgca agcggcgctg cagcttcgat gggggttgct tacggctccg gagccatcaa 1463761 aaagaaaact tacgctttga tcctatgcgc agtcggtgtc tttgccgggg cggtcattgg 1463821 cggaggcgag gttgtaaaaa caatcagctc cggcattatt cctgagcaga cgattacact 1463881 gacgattgtt tgcatcatta ttggagctgc tgccctgtcg ctctttactg ctaatctgct 1463941 cggcattcct ttgtcgacaa gtgaagtaac agtcggcgcg gttgtcggcg tgggagtggc 1464001 ttataaagta ttgtttgtga acaatcttct gatcattgtg tcattttggg tttttgtccc 1464061 gctgttcgct ttcggcttca cctatttcgt atctaagctg tttcgttatt ttaagattga 1464121 agtaaaatct tctaaaaagc aaaaaatcct cggcattgtt ttgttagttg ccggattttt 1464181 cgaagcattc tctgccggca tgaataacgt ggcgaatgct gttggcccgt tagtagctgc 1464241 cggtgtgctt gatgtcggaa aaggaacctt gtatggagga gcttttgttg ctcttggcgc 1464301 actgttatta ggccggcgag tgctagaaac aaacgggaag aaaattacga ggttctccaa 1464361 aggggaaggc attctcttat ccggtacagg agcgggactg gtgatcatca gttctgtatt 1464421 tgggatgccg gtgcccttgg cgcaagtcac gtcatcgtct attatcggaa taggcatggc 1464481 gaaaaacggt ccgaacgtgt tccataaaca agttgttcaa acgatgctga aggtatggat 1464541 cgtatcgccg tttttatctt tatcgatttc ttatctgctt gtatccttgt ttttaaaagc 1464601 agattattat tcgatcttta tcatggtaag tgtgctttta gcggcgggcg gtgccatcag 1464661 cctgacaaag gccattcgta aagagagacg ctcagtccac gaacaaggcg ggggaatctg 1464721 atcattaatc tgagtaattt tataagttaa ctaggaggag atggatatta tgagcttagc 1464781 accacacgga ggaacattag taaacagagt agatgaatca tatgatgtga gcggcattca 1464841 aaaagaaatt gaacttgatt taatttcttt cgcggatttg gaattgatcg gtatcggtgc 1464901 atacagcccg attgaaggtt tctttaatga aaaagattac gtatcagtgg tcgaaaacat 1464961 gcgtctttct tccggcgttg tctggtctct tccaatcacg cttccggtcg atgcgcaaaa 1465021 agcagcggaa ctgtcacttg gtgaaacggt aaagttaacg tatgaaggag aaacttacgg 1465081 cgttatccaa atcgaagacc tgtacgtgcc tgacaaacaa aaagaagctg tcaatgtgta 1465141 caaaacagat gaacaggagc atcctggtgt taaaaagctg ttcagccgcg gcaatacata 1465201 tgtcggcgga ccgattacgt tgattaaaaa agcttcaaaa cagttccctg aatttacatt 1465261 tgaaccgtca gaaacgagac gccagtttgc ggaaaaaggc tgggaaacca ttgtcggttt 1465321 ccaaacaaga aaccctgttc acagagcgca tgaatacatt caaaaaacgg ctcttgaaac 1465381 agtagacggc ttgttcttga atccgttagt aggtgaaaca aaatctgatg acattccagc 1465441 tgatgtacgg atggaaagct accaagtgct tcttgatcat tattacccga aagatcgtgt 1465501 tttccttggt gtctttttag cggcgatgcg ttatgcaggc ccgagagaag caattttcca 1465561 cgcgcttgtc agaaagaact acggctgcac acatttcatc gtcggccgtg atcatgcagg 1465621 tgtaggcgac tattacggaa catacgaagc acaggaactg tttgacacat ttaaacctga 1465681 agaactcgga attacaccgc tgaaatttga gcacagcttc ttctgtaaaa aatgcggaaa 1465741 tatgggaaca gcaaaaactt gccctcatgg cagagagcat cacgtcattt tatcaggcac 1465801 taaggtaaga ggtatgctga gagacggtgt gctgccgcct gctgaattca gtcgaaaaga 1465861 agtagtagaa gtgttaatca aagggatgaa gaaaaaagaa gaagtaggcg tatcttaagg 1465921 aggactggca gtgacaaatc gcgatattgt atggcatgaa gcctctatca caaaagaaga 1465981 gtatcagcaa aaaaacaagc ataaaagctc cattctctgg ctgacagggt taagcggctc 1466041 aggcaaatca accattgcca acgccgctgc gagagaattg tttgagcaag gctaccaagt 1466101 cattgtgctg gacggggata atatccgtca cggcctaaat agggatcttg gtttttctga 1466161 tgaagaccga aaagaaaaca tccgccggat cggagaggtg gcgaagcttt ttgttcagca 1466221 gggaaccatt gtgattactg cttttatctc tcctttccgc gaggacagac aacaggttcg 1466281 cgagcttgtg gaagcgggcg aatttaatga agtctacatt aaatgcgacc ttgatatttg 1466341 tgaacaaaga gatccgaaag ggctttacaa aaaagcaaga aacggcgaga ttccgttctt 1466401 tacaggaatt gattctcctt atgaagaacc ggaagctcca gagctcgttc ttgattcagg 1466461 acagcatgac cgtgaagcgt gtaaaaatca gctgatcgag tttgttaaac aaaaattgag 1466521 ctgaatatga tctgctgcgt tcttctcaga tgccggaatg caagcgagaa catcatcaca 1466581 gcgaatcttc tggaagaact cgaatagatc gggggaaata cgatggggaa agtatatatt 1466641 gtaggagcgg gtcccggtga ccctgatctg ctgacaatta aagcgctgaa agccattgaa 1466701 aaagctgatg tcatcttata tgacagatta gtaaataaag agattttaca atatgccaaa 1466761 gagcaagcag acctgatcta ctgcgggaag cttccggatt ttcatacgat gaagcaggaa 1466821 accatcaatc gatttcttgt gaagtatgcg caaaaaggga aaatggttgt cagactgaaa 1466881 ggcggagacc cttttgtgtt cgggagagga ggggaagaag cggaatgcct ctctgaaaat 1466941 ggaattccgt ttgaaatcat tcccggcatt acgtctggaa tcgcggcagc cgcttatgcc 1467001 gggattcctg ttacccatcg ggatgcgggc tctaacgtcg cttttgtaac gggtcactat 1467061 aaaaaagaag aagattttga ggaaaagtgg aaagcgctgg ctacaggaat tgatacactt 1467121 gtcatctata tgggtatcaa aaacgtgcag cagattgaaa gaaaactcct tgaaaatggc 1467181 cgggacggtt ctacgccagc agcctttatt cattggggga caacggacaa gcaaaaatct 1467241 gttttttgta cagttgacac cctttcagaa acggtgataa aagaaaacat tacaaatccg 1467301 agtttaattg tcattggaaa tgttgtaaat tatcactata agctggaatg gtttgaatct 1467361 gaactaaaaa aacaagattt aagcgaggcg ttgtaaaaat gaaacaagca attttatatg 1467421 tcggccacgg cagccgggtc aaaaaagcgc agcaagaagc cgcagccttt ttggaaggat 1467481 gcaaggccca catctctgtg ccagtacaag aaatcagctt tttagagctt caggagccga 1467541 caattgagac aggatttgaa gcatgtgtga agcaaggtgc cactcatatc gcagtggtgc 1467601 ctctgcttct tttaacagct gcgcatgcaa aacatgatat tccggaagaa attgtccgtg 1467661 ttgcatctcg atatccatca gtccgtattt catacggaaa gccgatcggg attgacgaag 1467721 aagtagtcaa ggctgtatat caccgaatga aagacatagg tgttccgtat gaaaatgcca 1467781 gagtggtgct catcggaagg ggaagttcag atccagacgt caaaagagac gtaaccggaa 1467841 ttgctaatct tcttcaggaa atggttccag tgaaggaagt cattccgtgc tttttgacag 1467901 catgcggccc taattacaaa gaggtttttt cagaacttga aaaagatgac ggcataacaa 1467961 cctttatcgt tccatatttg ctttttacgg gtatgctgat gaatgaaatc gaacgagagg 1468021 ttcagaaatt aaaagcccat aatccgaacg tctacctctc ttcctatatc ggttttcatc 1468081 ctcatgtgaa aaacgcattt ttgaaccgtg tgagagaaac tgcggcaaat tctgagggac 1468141 aatttgattt tgatggaggt tcatatgctt ccgctgcaca ttagcctgga aaagaagaag 1468201 gttgtgattg cggggggcgg aagcatcgct ctcagaaggc tgaaaacggt gatttctgag 1468261 ggagctgata taacgcttgt cagtccggat gtggaaccgg aaatcaagca aatggcagaa 1468321 gagcggcgta tcaaatggga aaaacggaca attgaaaaag aagattatct caatgctttc 1468381 ttcattattg ctgcgacgga taatgcggca gtgaacaaag aaattgccca atccgcttcg 1468441 ccttttcagc ttgtcaattg tgtcagtgac gctgagcttg gcaatgtata tatgccgaaa 1468501 atcgtaaaaa gagggcatgt cactgtgtct gtttctacaa gcggagccag tccaaagcac 1468561 acgaaagagc ttgctgaaaa cgtggataag ctgattgacg gcgattttgt tgctgaagtg 1468621 aacaggcttt atcagatgag aagaaagaaa taagccagag catacaaatg ctctggcttt 1468681 tctttatgcg gctcagcttt ttttgagctt gatgacagta tcagcatcag gcgtgacaaa 1468741 gacggtatgc tggctgtcat aagtgacgaa accgggtttc gcgccgtttg gttttttgac 1468801 atgcctgatt tttgtataat ctacaggcac tgaacttgaa tctttagctt ttgaaaaata 1468861 agctgcaatt gtcgcggctt ccatgattgt ttgctcatca ggttcgctgc ttctgatcac 1468921 aacgtgggag ccgggaatgt ccttcgtgtg aagccagata tcgtctctgg ccgccactct 1468981 tgtcgttaaa tattcatttt gacgattgtt cttacccact aaaattgtca gccctgaggt 1469041 ggattcatat gtttctaaca ccggattgtg cggtttttgc tttttctggc ctttttgctg 1469101 cttagggcgt aaatatttgc cctcaacaag ctcttccctg atttcgctga tatcccgggg 1469161 agaagcggac gaaagctgct gaatcagctg atcaaaatat tcgatctctt cctgtgccag 1469221 cctgatttgc tcctcgacaa ctgcgaccga atttttcgct ttctgatact tcgtgaaata 1469281 ggcctgtgcg ttttcagaag gcgttttgtt cgggtttaaa ggaatcgtga ttgtcgggct 1469341 ttcttcatca taataattga tgacctcagc ctgtttatca ccttttttca gcatatataa 1469401 attagcggtt aaaagctctc cgtaaagctg aaattccttc gcgttttccg aatactccag 1469461 ggttttctct aattttttga ttttgttggc attcttcttc cgttcgttca caacaaaacg 1469521 ctcaagatcc tgagcctgtt gcttaacccg gtctcgttca gcttttccga aataaaaacg 1469581 gtcgagcagt tcgcttaatg aatcaaaacg gcgcgcttcg ccctttagat gagtcagctc 1469641 cagcagataa aaatattcct ttccgtttac agtcgtaatg ttgggaatga aacggtgctc 1469701 tttcacttcg gcaaacagtg ccagcaacgc ttttggcagt gtgactttgt tggcaaggcc 1469761 tgctctgtga accgcttctt tggcgaaaag cggagacacg cctgaaaagt ggtcgacaat 1469821 ttgtttatca agccttcctt cttgaaagct gaggtgacgc aaaatatcat cttctgacgc 1469881 ctcaagaggc gatattttgt cctgagcagg cggaagctta taatcttggc cgggcagtac 1469941 tgtacggtag ctgttcattg acggtgataa atgcttaagt ccgtcgataa tcacattttc 1470001 tgctgcgtca gtcaaaatga tattgctgtg gcggcccata atttctacat aaagctttcg 1470061 tacggtttca tcgccaattt cgtttcggct tttgatatga aaaatcataa tgcggtctaa 1470121 gcccgcttgt tcaattttct caatgaatcc gccttcgata tgctttctca gcaacatgca 1470181 aaacattggc ggttcgcttg gattttcata agcttgtgcc gtgatatgca cccgtgaata 1470241 gctcggatgt gccgataata atagtttttg gttttttccc ttggcacgga tgtggaaaat 1470301 cacatcgtgc ttatatggct gatggatttt tgtaattcgt ccgcccatta ttttctcgtt 1470361 aagttcgtgt gtcattccgt atgtaaacat gccatcaaac gacatatgca atacaccctc 1470421 tcattcttcc tgcattcgat aattatagca tgaaatggga cgagtcagaa taagcatgct 1470481 tatagagtga tatctctata agagagcagg ggagtggacg agcggaatga agtttcatga 1470541 aatgggacaa acagatttac tagaggcaac caatacgtcc atgaaacaag gattaacaga 1470601 aaaagaggta aaaaaacgcc ttgacaagca tggaccaaac gagctgcaag aagggaaaaa 1470661 aacttcagcg cttctcttgt ttttcgcgca gttcaaagat tttatggtgc ttgtgcttct 1470721 ggcggcaacg ttaatctcag gatttcttgg tgaatatgta gatgcggttg cgattattgc 1470781 gattgtgttt gtgaatggca tactcggttt ctttcaagaa aggcgtgctg agcaatctct 1470841 tcaggcttta aaagagcttt caacaccgca cgtcatggca ctcagggaag gaagctggac 1470901 aaagattcct tctaaggaac tggtgccggg tgatattgtg aaatttacga gcggggacag 1470961 aattggcgca gacgttcgaa ttgttgaagc gagaagcctt gaaatagaag aatcagcgct 1471021 aaccggggaa tcaatcccgg ttgtgaagca tgctgataaa ttgaaaaaac cggatgtttc 1471081 actcggcgat attaccaata tggcatttat gggtacgatt gtgacccgcg gcagcggtgt 1471141 cggggttgtc gtcgggacag gaatgaatac ggctatgggg aaaattgccg acatgcttga 1471201 atcggcaggg acattgtcaa ccccgctgca aagaagactg gagcagctcg ggaagatttt 1471261 gattgttgtt gcattgcttc tgaccgtact tgtcgttgct gtcggtgtta ttcagggtca 1471321 tgatctgtac agtatgtttt tagcaggtgt ctcgttagcg gtagccgcta ttccggaggg 1471381 gctgccggcg attgtgacag tggcgctttc gcttggtgta cagaggatga ttaaacaaaa 1471441 atccattgtt agaaagcttc ctgctgttga aacgcttggg tgtgcgtcta tcatttgctc 1471501 agataaaaca gggacaatga cccaaaacaa aatgacagtg acgcatgtct ggtccggagg 1471561 gaaaacatgg agagtggcag gggccggcta tgaaccgaaa ggaagcttca cactaaacga 1471621 aaaagagatc agtgtcaatg aacataagcc gcttcagcag atgcttctgt tcggagcgct 1471681 ttgtaacaac tccaatattg agaaaagaga cggcgaatat gtgcttgacg gagatccgac 1471741 agagggagcg ctgctcaccg cggcaagaaa aggcggtttt tcaaaggagt ttgttgaatc 1471801 taattacaga gtgattgaag aatttccgtt tgattccgca cggaaaatga tgactgtcat 1471861 cgtagagaat caagacagaa agcgctatat cattacaaaa ggtgcgccgg atgtactcat 1471921 gcagcgatct tcccgtattt attatgatgg ctcagcggct cttttttcaa atgaaagaaa 1471981 agcagaaaca gaggcggtat taagacattt ggcatcacag gcgctcagaa cgatagcggt 1472041 cgcctacagg ccgataaaag caggcgaaac accgtcaatg gagcaggcgg aaaaagatct 1472101 gaccatgctt ggcctttcag gtatcattga tcccccgcgg ccggaagtca gacaggcgat 1472161 taaagaatgc cgtgaagcgg gaattaagac cgtcatgatt acaggtgatc atgtagaaac 1472221 cgctaaagcg atagcgaaag acttgcgcct ccttccgaaa agcggcaaaa tcatggacgg 1472281 caagatgctg aatgaacttt ctcaagaaga gctttctcat gtggtggagg atgtgtatgt 1472341 atttgcccgc gtttcccctg aacataaact aaaaatcgta aaagcctatc aggagaacgg 1472401 gcatattgtg gcgatgacgg gagacggcgt caatgatgct cctgccatta aacaggctga 1472461 tatcggcgtc tctatgggca ttaccgggac agatgtggcc aaagaagcat catctcttgt 1472521 tctcgtggat gataattttg cgacgattaa atcagcgata aaagaaggca ggaacatcta 1472581 cgaaaatatc aggaagttta tcagatacct gttggcgtct aacgtcggag aaatccttgt 1472641 catgctgttt gcgatgctgc ttgcccttcc tttaccgctg gttccgattc agattttgtg 1472701 ggtcaacttg gtgacggacg gattgccggc aatggcgctc ggcatggatc agccggaagg 1472761 agacgtcatg aagcgcaagc cccgtcatcc gaaagaaggg gtatttgccc gcaagctagg 1472821 atggaaggtc gtttccagag gatttttaat cggagttgcc actattttag cgtttatcat 1472881 tgtgtaccac cgcaatccgg aaaacttggc ttatgcccag acgatcgcgt ttgccacatt 1472941 ggtgctcgct cagcttattc acgtgtttga ctgccgcagc gaaacttctg ttttctctag 1473001 aaatccgttt caaaacctgt atttaatcgg cgcggtattg tcatccattt tgctgatgct 1473061 tgtagtaatc tactatccgc cgcttcagcc gattttccat actgtagcca tcacgccggg 1473121 ggactggatg ctcgtcatcg gtatgtccgc catccctact tttttgctgg cggggtcact 1473181 tttaacaaga aaaaaataaa ttcatatgat ataatcttag gggtaatagc gtgtctattg 1473241 cccttttatt atgagaacag ggaagaattg ggtgttttaa aatgatacga agtatgacag 1473301 gcttcggcag tgcaagcaaa acacaagacg atctctctgt aagcgttgaa cttaaatctg 1473361 tgaactacag atttaaagaa gtgaacgctc gtttgccaag gcctttgcta tattttgaag 1473421 ataagctgaa acagaccatt ctgcagcata ttcagcgcgg aagaattgag cttttcgtat 1473481 ccgttgacag cgatatgctt gttgagaaaa ggcttgaaat tgattggccg ctgctcgatg 1473541 agtttgtcgc agccgcgaga gatatgaaga agcggtatca attgtctgca gagcccgatg 1473601 taatggattt ctttaagctt gatcatgtcg tccaggttca tgaagaacag acgcaaaatg 1473661 acaagctgga ggcgttgatc atcgatgctg cagaagaagc ggtaaaaggt ctctgtgaaa 1473721 tgcgtgaaaa agaggggctg ctcttagcga aagactgcct gatgcatatt gatcagcttg 1473781 aagagctggt gagagaaact gaattgctgg ctgcagatgt cgtatctcgt taccgggaac 1473841 ggctgtatgc cagaatcaaa gaatggactg aagacgtatt agacgagagc cggcttgtaa 1473901 cagaatgcgc tatttttgca gaccgctctg atatcactga agagattaca aggctgaaga 1473961 gccacttcgc ccagtttcgt gatatattag ctagtggcgg agctgtcggg cgcaaactcg 1474021 actttcttgt tcaggagctc aatcgggaag caaatacgat cggctcaaaa gcaaatgatc 1474081 atcagatcac aaagcttgtc gttgaaatga aaagttctat tgaaaaaata aaagaacaag 1474141 tgcaaaatat agaatagtga ctgtgcgtat tgtttacaga cggtcttact aggctaaact 1474201 agagacgtct attttacagg gggaacgtag aagatgacga ttaaactgat taatatcgga 1474261 tttggcaata tcatctccgc caatcggatg atttcgattg tcagcccgga gtctgcgcca 1474321 atcaaacgga tgattcagga tgcaagagac cgcggaatgc taattgacgc tacatacgga 1474381 cgaagaaccc gtgcagttgt cgtcatggat agtgatcaca ttatcttatc tgccgtccag 1474441 cctgagacag ttgcacacag actttctgtt aaagaagaaa ttatggatga agggcagggg 1474501 taattgccgc atgaaagaaa gagggttatt aatcgttctc tcaggtccct caggagttgg 1474561 taaaggaacg gttcgacaag cgatcttttc gcaggaagac acaaaatttg aatattcgat 1474621 ttcagtaacc acaagaagtc caagagaggg cgaagtgaac ggagtcgatt attttttcaa 1474681 aacaagagac gaattcgagc aaatgattgc ggacaacaag ctgcttgaat gggcagagta 1474741 tgtcggcaat tattacggca cgccagtcga ttatgttgaa cagacgcttc aagatggaaa 1474801 agacgtcttt ttagaaattg aagttcaagg ggctcttcaa gtgagaaatg ctttcccgga 1474861 aggcctgttt attttccttg cgcctccaag cctttctgaa ctgaaaaaca gaatcgtgac 1474921 acgaggaaca gaaacagacg ctctgattga aaatcgaatg aaagccgcaa aagctgagat 1474981 cgaaatgatg gatgcttatg actatgtcgt tgaaaacgat aatgtcgaaa cggcttgcga 1475041 taaaatcaaa gcaatcgttc ttgctgaaca tttgaagcgt gaacgcgttg caccaagata 1475101 taagaaaatg ctggaggttg aataatcaat gttagatccg tcaattgatt ctttaatgaa 1475161 taaattagat tcaaaatata cgctggtgac tgtttctgcg agacgtgccc gtgaaatgca 1475221 aatcaaaaaa gaccaaatga ttgaacatac gatttcacac aaatatgtag gcaaagcttt 1475281 agaagaaatt gatgcaggcc tgctttcgtt tgaaaaggaa gaccgcgaat agtagcacaa 1475341 gtagcaacct atatcatgta ggttgttatt tttttccgtg cggttttgta aagtgcagag 1475401 ggggagaatt cattgcttaa caatcgaaat gtgttacttt gcgtgagtgg aggcatcgct 1475461 gtttataaag cctgtgcgtt aacgagcaag ctggttcagg caggagcaaa tgtcaaagtg 1475521 attatgactg aatccgcttg ccgattcgtt tcaccgctga catttcaggc attgagccgc 1475581 cacgaagtct atacagatac atttaaagaa caaaatccaa gcgtcatttc tcatattgat 1475641 gccgcagact gggccgactt gattatcgta gcgccggcta cggctaatgt gattggaaaa 1475701 ctggcaaacg gcatcgctga tgatatgctg acgacaacat tgttggcagc aacggctccc 1475761 gtttggatcg cgccggcaat gaacgttcat atgtatgacc acccggcagt caaacgaaac 1475821 atttctgttc tttatcagga cggttattgt tttattgagc caagtgaggg ctatttagca 1475881 tgcggttacg taggaaaagg cagattggaa gagccggaaa acatcgtaaa gctggccgaa 1475941 aaacattttg ctgaagaaac atccgctcct ttagaaggca agcatgtggt cattacagcc 1476001 ggcccaacgc gggaagcgat tgatcctgtc cggtttttta ccaataaatc gacgggcaaa 1476061 atgggctacg cactggcgga ggctgctgtt cagctcggcg cacgggtaat cttaatttct 1476121 gggcctgttt cacttgatca gcctaaaggc cttgctgagt ttatccctgt tcaatcggct 1476181 gcggatatgc gcgaagctgt gctctctgtg tatgacgcaa gcgatatagt cattaaaaca 1476241 gctgcggtag ccgattttac gccgaaaaca gtatttgacc ataaaatgaa aaaacaagac 1476301 ggcggcatga ccttagaact gaaaagaaca gtcgatattt tgaaagaatt gggcgagaaa 1476361 aagaaagagc agattttggt cggatttgcc gccgaaacac aagacattga acactatgca 1476421 cgtaaaaagc tcgccgctaa aaaccttgat ttgattgtgg caaatgatgt gaaagcaaat 1476481 ggggccggtt ttggtgctga tacgaatatc gtgacaatct ttttcaaaga cgggcataaa 1476541 cgcgaactcc cgattatgtc taagctcgat gtttcttttg aaatccttca ggagatcgca 1476601 gccctctcaa aacaaaccgg agagcgctca tgaattttgc agaagtcatc gttgatgtca 1476661 gcaccaaaaa tatagacagg ccttttgatt ataaaatccc agaccatctg aagggcatga 1476721 tcaaaacggg gatgcgggtc attgttccgt ttggcccccg taagattcaa gggtttgtga 1476781 cagcagtcaa agaagcatct gacctatcgg gaaaatctgt caaggaagta gaggatttat 1476841 tagatcttac acctgttctg acagaggagc ttatgattct gtcatcatgg ctgtcagaca 1476901 aaacgctgtc ttttaaaata acggcgcttc aagcaatgct gcctgccgcc ttaaaggcga 1476961 aatatgaaaa agaattaaaa attgcacacg gagccgatct tccgccgcaa gtggaacggc 1477021 tgttttctga aacaaagacg ctgctgtatt cagatatacc cgatcatgag acgctgaaac 1477081 tgattcaaag gcatgttcaa aaaggggaca ttgacgtgac gtataaagtc gcgcaaaaaa 1477141 ccaataaaaa aatggtcagg catattcagg caaatgcgag taaagaagag cttgctaagc 1477201 aggctgaggg attgtcccgc caagcagcaa aacagcaggc gattcttcac tttctcatct 1477261 ctgagccgga aggtgtgaaa attcctgcgg cggaattgtg caaaaaaacg gacacgagct 1477321 ctgcaaccat caaaaccctt atccaaaaag ggcttttgaa ggaaagctat gaagaggttt 1477381 acagagatcc ctatcaggac aaaatgttca aaaaaacaga gcccctgccg ctgacagacg 1477441 aacagagggc tgccttcgag cccatacgcg agacattgga cagcgatgag cataaagtgt 1477501 tcctccttca cggcgtgaca ggaagcggaa aaaccgaaat ttatctgcaa tcaattgaaa 1477561 aagtactggc gaaaggaaaa gaagccatcg tcctcgtacc ggaaatatcg ctgacgccgc 1477621 aaatggtcaa ccgcttcaag ggccgcttcg gctcccaggt ggcagtcatg cacagcggtt 1477681 tatccacagg agaaaaatat gacgagtggc gtaaaatcca ccggaaggaa gtacggcttg 1477741 tcgtcggtgc cagatccgcc atttttgctc cgtttgaaaa tctcggaatg ataatcatcg 1477801 atgaagagca cgagtcttcc tataaacagg aagaaatgcc gcgctatcat gcgaaagagg 1477861 tggcaatcaa gcgggctgag catcacagct gcccggttgt attagggagt gctacgccga 1477921 cattagaatc atatgctaga gcgcaaaagg gcgtatacga gcttctttca ctgaagcacc 1477981 gtgttaacca tcgggtgatg cccgaggttt cgcttgtcga tatgagagag gagcttagaa 1478041 acggcaatcg ctcgatgttt tcagttgaat tgatggaaaa gcttgaagaa acgattgcca 1478101 agggtgagca ggcggtgctg tttttaaata agaggggcta ctcttccttt gtgatgtgca 1478161 gggattgcgg ctatgtcccg caatgcccgc actgcgacat ttccatgacg tatcatcgtt 1478221 acggccaaag gctgaaatgc cattattgcg gacatgaaga gcctgttccg cacacttgtc 1478281 ctgaatgcgc aagcgagcat atccgctttt tcggaacggg aacacagcga gtggaggaag 1478341 agctgacaaa agtgctgcca agtgcgagag tgattcggat ggatgttgac acgacatcac 1478401 ggaaaggcgc ccatgaaaaa ttactgtcag ctttcggaga aggaaaagcg gatattcttc 1478461 tcggaacgca aatgatcgcg aaagggcttg attttccgaa tgtcacgctt gtcggagtgt 1478521 taagtgctga tacaacactt catattcctg atttcagatc ggctgaaaaa acatttcagc 1478581 tgttaacgca agtcagcggc cgggcaggca ggcatgaaaa gcccggccat gtcatcattc 1478641 aaacgtatac accgtctcat tacagtatcc agctgacgaa aacacacgat tatgaaacgt 1478701 tctatcagca tgaaatggcg cacaggagag agcaatccta tccgccatac tactatttgg 1478761 ctcttgtgac tgtttctcat gaggaagtgg cgaaagcagc ggttacagct gaaaaaatcg 1478821 ctcatttttt gaaagcaaac tgcggagctg acacgaaaat tctcggacca agcgcgtcgc 1478881 cgatagccag gatcaaagat agatatcgct atcaatgcgt gataaaatac aaacaggaaa 1478941 cccagttatc cgctttattg aagaagatac tggaacatta taaacgcgaa attgaacaaa 1479001 aacatgtaat gatttcaatt gatatgaatc cttatatgat gatgtaagat ctcacgtctt 1479061 ggagggtaac aaattggcag taaaaaaggt cgtcacacat cctgcggagg ttttggaaac 1479121 acctgcggaa accgtgactg tttttgataa aaagctaaaa aaactgcttg atgatatgta 1479181 cgacaccatg cttgaaatgg atggtgtcgg actggcagcg ccgcaaatcg gcattttaaa 1479241 aagagcggcc gtcgtagaaa tcggggatga cagagggaga attgatctcg ttaatcctga 1479301 aattttagaa aaaagcggcg agcaaaccgg aattgaagga tgcttgagct ttcctaacgt 1479361 ctatggtgat gtcacacgtg ccgattatgt caaagtgcgt gcgtttaacc gtcagggaaa 1479421 accgttcatt ctggaagcgc gaggcttttt agcaagagcc gtgcagcatg aaatggacca 1479481 cttagacggt gtgctgttta catctaaaat aagtaaatac tatacagaag atgaactagc 1479541 ggatatggaa ggatgatttg atgacgagaa tcgtatttat gggaacgccg gatttttcag 1479601 ttcctgtttt aagaaccctg atagaggacg gatatgaagt agtgggggtc gtcacacagc 1479661 cggaccgtcc gaagggcaga aaaaaagtac tgacacctcc tccggtaaag gaagaggcat 1479721 tgcgccacgg catcccggtt cttcagccgg aaaaagtcag attgacagaa gaaattgaaa 1479781 aagtgctggc attaaagcct gacctgattg taacggcggc attcggacaa attttgccta 1479841 aagagcttct cgacagtcca aaatacggct gcattaacgt tcacgcatcc cttttgccgg 1479901 aactgcgcgg cggtgctccg atccattatt ccattctgca gggaaagaag aaaaccggga 1479961 ttaccattat gtatatggta gaaaaattgg atgcgggcga tatgatctca aaagtggaag 1480021 tggacattga agaaaccgac aatgtcggaa cactgcacga taaattaagc gttgctggcg 1480081 cgaagctatt gtctgaaacg gttccaaacg ttattgccgg cagcatatca cctgaaaagc 1480141 aggatgaaga gaaagcgacg tacgcgccta acattaaaag agagcaagag ctgctcgact 1480201 ggtccagaac gggcgaagag ctttacaacc agatccgcgg cttaaatcca tggcctgttg 1480261 cttatacgac tctaaacgga caaaacttga aaatatgggc gtcgaaaaaa atagcggcac 1480321 caacaacagc tgagcccggc acagtcgttg cagttgaaaa ggaaggaatt atcgttgcca 1480381 caggtaacga gacggctctg ttattaaccg aactccagcc ggcaggcaaa aaacgaatga 1480441 aaggcgaaga ctttgtgcga ggcgctcatg ttgaagccgg tgatgtgtta ggagtaaaca 1480501 atgaaaaaaa ctagtgttcg tgacatcgcc cttgaggcgc tgatcaaatt agaacaaaac 1480561 caggcataca gcaacctgct gctgaaatcg gtcattaaat caaatgaact gagtgatcag 1480621 aacagagggc ttttgactga acttgtctat ggtacattac aaaataagat cgcgcttgat 1480681 tatatgctta aaccgtttat caataagcct caaaaggtaa agccgtgggt gattcagctt 1480741 cttcgcctat ccttatatca aatggagtat ttggagaaga ttccagacag ggcagccatt 1480801 catgaagcgg ttgagattgc taaaatccgc ggacacaaag gcattgcttc atttgtcaac 1480861 ggcgtgctcc gttctattca gcgcgaaggt gttccatcct ttgacgcgat cgaagatcct 1480921 gtccgccggc tggcgacaga aacaagccat ccggaatggc ttgtgaaaga gtgggcggat 1480981 gcgtatggat ttgaagctgc ggaaaagatt tgccgcatcc atctcattcc gccgaaacag 1481041 acgctgcgtg tcaatcaaat gaaagcagac agagctgagc tgcttgacca aatggctgct 1481101 gagggaatcg aagttgaaaa aggcgacctc gctgaagatg ctgtgaagct cttaaaggga 1481161 acaattgccg gaactcattt cttccaaaac ggcgaagttt ctatccagga tgagagctcc 1481221 atgctcgtcg cccgcgccct tgatcctaag tcagatgaaa cagtgcttga cgcgtgtgcg 1481281 gcgcctggcg gaaagtcggc tcatatcgca gaattaatga agaacaaggg gagcgttacg 1481341 tcgcttgatc ttcacaaaca taaagtgaag ctgatcaaag aagcggcaga tcggcttggc 1481401 ctgacaatca ttcatgcgga aacaatggat gctagaaaag cgggggaaac gtttgaaaac 1481461 gaacagtttg accgaatatt ggtcgatgcc ccgtgctcag gtttcggtgt tatcagaaga 1481521 aagccggaca tgaaatacac gaaaaaacct gacgacagcg cccgtctagc tgaaatccag 1481581 ctgtcgatct tgagggaaat cgcaccatta gtaaaaaaag gtggcactct tgtctacagt 1481641 acgtgtacaa tggaccggac agaaaatgat gaagtaatac atgcgtttat acaagaacat 1481701 cctgattttg aacccgattt gtctcttgaa aagcggctgc ctgaaaaggt gagacccttt 1481761 gttcgggatg gaaggcttca aatccttcct cattatttcg gaacagatgg tttctttatt 1481821 tgcagcatga gaaagaaggg ataagcaatg gcagaactta ataaaacaaa agtaagaaaa 1481881 gaattgcgga cagagcgtcc gtctatttat tcttttgaat tagatgaaat caaacaatgg 1481941 ctgacagaca atggagagaa accgttccgt gcagcccaga tctttgaatg gctatatgaa 1482001 aaacgcgtat cttcttttga agatatgaca aacctctcaa aggatctgcg tgagaaatta 1482061 aacactcgct ttgtgttaac aacgctgaaa acggctgtta aacaaacctc tcaagacggt 1482121 acgatgaagt ttttgtttga gcttcatgac ggttatacca tcgaaaccgt tttaatgaga 1482181 cacgagtatg gcaattctgt atgtgtaacg acacaagtcg gctgccgtat tggctgcaca 1482241 ttctgcgcgt caacgcttgg aggcttaaaa cgaaaccttg aagcagggga aattgtcgct 1482301 caagtagtca aagtgcaaaa agctcttgat gaaacggatg aacgcgtcag ctctgtcgtg 1482361 atcatgggaa tcggcgaacc ttttgataac tttaacgaaa tgctcgcttt cttgaaaatc 1482421 attaaccatg acaagggcct gaatatcggt gctcgccata ttacggtctc tacgagtgga 1482481 atcatcccga aaatttacga atttgctgat cagcaaatgc agattaactt tgcaatttct 1482541 ctgcacgcgc cgaacacaga aatcagaagc cgtttgatgc cgattaacag agcatataaa 1482601 ctgcctgatc taatggaagc cgttaaatat tatattaata aaacaggacg ccgtatcagc 1482661 tttgaatacg ggctgttcgg aggcgtaaac gaccaggtgg aacacgccga agagcttgcc 1482721 gacttgctgg aaggagtcaa atgccacgtg aacttgattc cggtaaacta cgtgcctgaa 1482781 cgggactatg tgcgcacacc gcgtgatcag atttttgctt ttgaaaaaac gctgaaatcc 1482841 cgcggagtaa atgtcacaat ccgaagagag caaggacatg acattgacgc agcctgcggt 1482901 cagcttcgcg cgaaggagcg tcaagacgag acgaggtgat gagggttgtt aacagcctta 1482961 aaaacagata caggaaaaat ccgccagcat aatgaagatg atgcggggat attcaagggg 1483021 aaagatgaat ttatattagc ggttgtcgct gatggcatgg gcggccatct tgctggagat 1483081 gttgcgagca agatggctgt gaaagccatg ggggagaaat ggaatgaagc agagacgatt 1483141 ccaactgcgc cctcggaatg tgaaaaatgg ctcattgaac agattctatc ggtaaacagc 1483201 aaaatatacg atcacgctca agcccacgaa gaatgccaag gcatggggac gacgattgta 1483261 tgtgcacttt ttacggggaa aacggtttct gttgcccata tcggagacag cagatgctat 1483321 ttgcttcagg acgatgattt cgttcaagtg acagaagacc attcgcttgt aaatgaactg 1483381 gttcgcactg gagagatttc cagagaagac gctgaacatc atccgcgaaa aaatgtgttg 1483441 acgaaggcgc ttggaacaga ccagttagtc agtattgaca cccgttcctt tgatatagaa 1483501 cccggagaca aactgcttct atgttctgac ggactgacaa ataaagtgga aggcactgag 1483561 ttaaaagaca tcctgcaaag cgattcagct cctcaggaaa aagtaaacct gcttgtggac 1483621 aaagccaatc agaatggcgg agaagacaac attacagcag ttttgcttga gcttgcttta 1483681 caagttgaag agggtgaaga tcagtgctaa tcggcaagcg gatcagcggg cgttaccaaa 1483741 ttctccgcgt cataggcggc gggggaatgg ccaacgtgta tttagctgag gatatcattc 1483801 tagaccgtga agtcgcaatt aaaatcctgc ggtttgacta tgcaaatgac aatgaattta 1483861 tcagacgttt ccgcagagaa gcccaatccg catcaagcct cgatcacccg aatattgtca 1483921 gcatttatga tttgggcgag gaagatgata tttattatat tgtcatggaa tacgttgaag 1483981 gcatgacgct taaagaatac ataacagcaa atgggccgct tcaccctaaa gaagcgctga 1484041 acatcatgga gcaaattgtc tcagccatcg ctcatgccca tcaaaaccag attgttcaca 1484101 gagacatcaa gccgcataac attttgattg atcatatggg aaatatcaaa gtaacggatt 1484161 ttggaattgc gacggcacta agttcgacca caatcaccca taccaattca gttctgggct 1484221 cggtccatta cttatcacct gaacaggccc ggggcggctt agccacaaaa aaatcggata 1484281 tttatgcgct tggaatcgtt ctatttgagc ttttaaccgg ccgtattccg tttgatggag 1484341 agtcagcagt cagcatcgcc ttgaagcatc ttcaagcgga aactccttcg gcaaaaaggt 1484401 ggaatccatc ggtcccccaa agcgttgaaa acatcatact caaggcaact gccaaagatc 1484461 cttttcatcg ctacgaaacg gctgaagaca tggaagcaga cataaaaaca gcttttgatg 1484521 ccgacagact caatgaaaag agatttacga ttcaagaaga tgaagaaatg acaaaagcga 1484581 tacctatcat taaagatgaa gaacttgcta aagctgctgg cgaaaaagaa gctgaagtga 1484641 caaccgcaca agaaaacaaa acaaagaaga acggcaaaag aaaaaagtgg ccgtgggttt 1484701 tgctcacgat atgcctcgtt tttatcacag ctggaattct tgctgtcact gtttttccgt 1484761 cgcttttcat gcctaaggat gtcaaaatac ctgatgtctc cggaatggaa tacgaaaaag 1484821 ccgcagggct cttggaaaaa gaaggtttac aggttgattc cgaggtgttg gaaatctcag 1484881 atgaaaaaat tgaagagggc ctgatggtaa aaacggatcc taaagcggat accacagtca 1484941 aagaaggcgc cacggtcacc ctttataaga gcaccggaaa agcaaaaacg gagatcggtg 1485001 atgtgacagg ccaaacggtc gaccaagcaa aaaaagcgtt gaaggaccaa gggtttaatc 1485061 atgtaacagt aaatgaagtg aatgacgaga aaaatgcggg cactgtcatt gaccaaaatc 1485121 cttcagcagg gactgagctg gtcccgagtg aagatcaagt caaacttaca gtcagtatcg 1485181 gacccgaaga cattacgctt agagacttga aaacctacag taaagaagca gcgtctggat 1485241 atctggaaga caacggattg aagcttgtag aaaaagaagc atactcagat gatgttccag 1485301 aaggacaggt tgtcaaacaa aaaccagcag caggtacggc agtaaagccg ggaaacgaag 1485361 ttgaagtgac attctctctc ggaccagaga aaaaacctgc gaaaacagtg aaagaaaagg 1485421 tcaagatccc ctacgaacca gaaaatgaag gggacgagct tcaagtgcaa atcgcggttg 1485481 acgatgcgga tcacagcatc tctgacactt acgaagaatt taagataaaa gagccgactg 1485541 aacgaacgat cgaactaaag attgaaccag gccaaaaagg gtactatcaa gtaatggtaa 1485601 acaataaagt tgtcagctac aaaaccattg agtatccgaa agatgaataa caaggaggga 1485661 aaatatgcct gagggcaaaa ttattaaggc gctaagcggc ttttactatg tactggatga 1485721 atcagaggat tcagataaag taatacaatg cagaggaaga ggcattttca gaaaaaacaa 1485781 aattacccct cttgtcggtg attacgttgt gtatcaagct gaaaatgaca aagaaggata 1485841 tctaatggaa attaaagaaa gaaccaacga gcttatcagg ccgccaattt gcaacgttga 1485901 tcaagcggtc cttgttttct cagcggttca gccttctttc agcacggcat tgctcgaccg 1485961 cttcctggtt ctcgttgagg ccaatgatat tcagccgatt atatgcatta ctaaaatgga 1486021 tctgattgaa gatcaagata cagaagatac gatacaagcc tatgcagaag actatcggaa 1486081 tattggttat gacgtatacc ttacctcctc taaggaccaa gatagtttag cggacatcat 1486141 cccgcatttt caggataaaa caacggtatt tgccggtcag tccggtgttg ggaaatcctc 1486201 gcttctcaac gcgatcagtc cggagctcgg attaagaaca aacgagattt ccgagcattt 1486261 gggccgcggg aaacacacaa cccgccacgt ggagctgatt cacacgtccg gaggtttggt 1486321 tgcagataca ccgggattca gctcgcttga atttacagac attgaggaag aagagctggg 1486381 ctataccttc cctgatatca gagaaaaaag ctcttcatgc aaatttagag gctgtttaca 1486441 tctgaaagag ccgaaatgtg cggtgaaaca agctgttgaa gacggggaat taaagcagta 1486501 tcgctatgac cattatgttg aatttatgac ggagattaaa gacagaaagc cgaggtatta 1486561 gcataatgat aaaggttgca ccatctattc tttccgctga ttttgccgct ttaggcaatg 1486621 agattaaaga tgtagaaaaa ggcggagccg attgtattca tattgatgtt atggacggcc 1486681 attttgtccc gaatatcaca atcggtccgc tgattgtaga agcggtccgg ccggtaacgg 1486741 atctgccgct tgatgtccat ttaatgatag aagagccgga tcgttatatc ccggcttttg 1486801 cgaaagcagg cgcagatatc ctgtctgtgc atgctgaggc atgtccgcac ctgcaccgta 1486861 ccatccagct cattaaagag caaggagtga aggccggagt agttctaaac ccgcataccc 1486921 ctgtacaagt catcgaacat gttttcgacg atcttgatct tgttctttta atgacggtga 1486981 acccgggctt cggcgggcag aaatttattc attcagtcct tcctaaaata aaagaggtta 1487041 agcgaatggc ggatgaaaaa ggaaaaaaag atctgttaat tgaagtagac ggcggcgtca 1487101 acaaagaaac cgctccgctc gtcattgaag cgggcgcaaa tttactcgtt gccggttcag 1487161 ctgtttatgg ccagtctgac cgcaaaaaag caatttctga aatcagagga agtaaataag 1487221 cagctttaga aaagagctgg gcatacaata gcctaagctc tttttcctgt atgcagagaa 1487281 aggaatcaga gatgaaaaca attaatatcg ttgcgggagg cccgaaaaat ctcattcccg 1487341 atctaaccgg ctatacggat gaacacacgc tttggatcgg tgttgacaaa ggcaccgtca 1487401 ctctcttaga tgccgggatc attcctgttg aagccttcgg agattttgac agcataacgg 1487461 agcaagaacg ccggcgaata gaaaaagccg ctcccgccct tcatgtgtat caagcagaaa 1487521 aagatcaaac agatttagac ctcgcccttg attgggcgct ggaaaagcag ccggatatta 1487581 ttcagatttt cggcattaca ggcggcagag ctgatcattt tttaggaaac attcagcttc 1487641 tgtataaagg tgtaaaaacg aacataaaaa ttaggctgat agacaaacaa aatcatattc 1487701 aaatgttccc tcctggtgaa tatgatattg agaaggatga aaataagcga tatatctcct 1487761 tcataccgtt ttccgaagac atacatgagc tgaccctgac cggttttaaa tatcctctaa 1487821 ataattgtca tattacgctc ggttcaacac tatgtattag taacgaactc attcattcac 1487881 gaggtacttt ttcgtttgca aaaggcatat taataatgat aagaagcacg gattaagcat 1487941 gtgctttcat tcaattgctg aaaacaatga acaaggcggt tacgggacgt tataggaggg 1488001 gacaaaaatg aaattttaca ccattaaatt gccgaagttt ttaggaggaa ttgtccgggc 1488061 gatgctgggc tcatttagaa aagattaatg cccaggggtt caaagccctc tttcaccaca 1488121 taaaaacgcc tgccacatat cggggcaggc gttcattttg ttatacacgc tcaactttac 1488181 cggatttcaa agctcgagca gatacatata cttttttagg ttttccgttc acaaggatac 1488241 gaaccttttg aagattcgcg ccccaagtgc gcttagaagc gttcattgcg tgagaacggt 1488301 tattcccagc tgttgttttt ttacctgtga taacgcattt acgtgccatt tgtttccctc 1488361 ctcacttgca caaaacatct actttttaac attcatataa tcttagatgc tttcgatatg 1488421 gatactttaa ataatttacc acagctaaaa aacgtttgca actattgttt catcatcttt 1488481 caagaaaatt cacttgacat cttgcggaaa cagcagcgct atagtatatg tagaggtacg 1488541 gccagcgatt attgcctggt cttttcataa tggaaaccat atagtagaat agctgtaact 1488601 ctatgcattc gaaggaggaa ctagtgtgtc cattgaatta agaacgaagt acggacagat 1488661 tgatatatct aatgaagtca tcgcgatggt tgcaggaggc gcggcggttg actgttacgg 1488721 cattgtcggc atggcctcta aaaaccagat taaagacgga ctgactgaaa tccttcggaa 1488781 agagaatttc agcaggggtg tccaagttcg ccaagaagga gaacagatac atatcgacat 1488841 gtatatcatt gtcagctacg gcacgaaaat ttctgaagtg gcacataatg tccaaacaaa 1488901 agtaaagtac acagtaaatc aaaccatcgg actggcagtg gattctgtca atatttatgt 1488961 ccaaggcgta cgagtgacga acccgtagtt aggaggagta ggattgtcta tcagaacatt 1489021 agacggcaga acctttgccg agatgattct tgcgggagcg cagaatctgt ctcaaaacgc 1489081 cagtgcagtt gatgcactga acgtgttccc ggtgccggac ggtgatacgg gaacaaatat 1489141 gaacctgtcg atgacttccg gagcaagaga agttgaacaa atggatacgg atgatatcgg 1489201 gaaggtgggc tccgcgttat ctaaagggct gctcatggga gcacgcggaa attcaggagt 1489261 tatcctatcc caattgttcc gcggatttag caaaaacatt gaaacgaaaa aagaaattaa 1489321 tgcacttgag tttgccgctg cgctgcaagc aggtgtagac atggcgtata aagctgtcat 1489381 gaaacctgta gagggcacca ttttaacagt tgcaaaagac gctgcaaaaa aagcaatgat 1489441 cttagcagaa aaagaaaccg atatcactgc gctgatgact gcagtgacag aagaagcaga 1489501 ggcgtcttta aaccgcaccc ctgaattgct acctgtccta aaggaagtag gagttgtcga 1489561 tagcgggggc aaaggcctgc tctgtgtgta tgaaggtttc cttgcttcat taaaaggtga 1489621 aactgtacct cagaaagcag ttcttccgtc acttgacgac atggtcagcg cagagcatca 1489681 caagagcgcg caaagcatga tgaataccga agatattgaa tttggattct gtaccgaagt 1489741 gatggttagg cttgatcaga caaaaagaga gttcgacgaa ggcacgttca ggcaagacct 1489801 cagccagttc ggagattctc tgcttgtgat tgcggatgaa tcgctggcga aggttcatat 1489861 tcatgctgaa gagccgggaa acgtgttaaa ctacgcccag cattacggtg aattgatcaa 1489921 aataaaaata gaaaatatga gagaacagca tacctctatc atcagtcaag aaagcaaacc 1489981 tgcagacaac gaaacaccgc cggcaaaaca gccgtatggc attgtgactg tagcgatggg 1490041 agaaggaatt gcagacctat ttaaaagcat tggcgcttct gttgtgattg aaggcggcca 1490101 gaccatgaac ccaagcactg aggatattgt tgatgccgtg aagtctgtaa atgcagatac 1490161 ggtatttatc ctgcctaaca actccaacat tatcatggct gctaaccaag cggccagcgt 1490221 agtggatgaa caggtttttg tcattcctgc taaaacggtt ccgcaaggga tgtcagctct 1490281 gctggctttt aacccggatc aagaagctga agcgaacgag gccaatatgc taagcgccat 1490341 tcagcaagta aaaagcggac aggtgacgtt ctcagtcaga gatactcata ttgacggtaa 1490401 agacattaaa aaaggcgact ttatgggcat tctgaatgga acgattatcg gcacttctga 1490461 aaatcagctg tcagccgcga aaatgctgct gtcagaaatg atcggagaag atgatgaaat 1490521 cgtgaccatt ctatatggtg aggatgcgtc tcaggaagaa gctgagcagc ttgaagcgtt 1490581 tctcagtgaa aagtacgagg agattgaggt tgagatccac aatgggaaac agcctctgta 1490641 ttcgtatata gtttcagcag aatagaaggg caatttgccc ttctattctt atgtctgctt 1490701 ttaagtgcgg cagcgctgta acgcgcccgc ttgccatttt atatctgatc aattagtcta 1490761 gaagcaaagc gctaataagc tctggttcat aaggaggaat agcatgaaat acagaagcgt 1490821 ttttgatatt atcggcccgg ttatgatcgg tccgtccagc tctcatacag cgggagctgc 1490881 tagaatcggg agagtggcca gaagtttatt tggcagagag cctgagcgca tcattgtatc 1490941 tttttacggc tcgtttgcgg aaacgtataa gggccacggc acagatgtcg cgattatcgg 1491001 cggattgctt gattttgata cattcgatga acggattaaa accgctatac aaattgcaga 1491061 agctaaagga attgatatag agtttcgggt agaagacgca gtcccggtcc acccgaacac 1491121 agcaaaaatc accatttctg atgaaaaggg tgagctggaa ctgacgggta tttcgattgg 1491181 cggaggaaag attgaaatca cagaattgaa tggttttgag ctccggctgt caggaaatca 1491241 tccggccata ttagttgttc ataatgacaa gtttggcaca attgccggtg ttgccaatgt 1491301 tctggcgaaa ttttcaatca acgtaggaca tatggaagta gcccggaaag atatcggcca 1491361 gcttgcgctg atgacaatag aggtcgatca aaatattgac gaccacattc tcgacgagct 1491421 gtcgaagctg ccgaatatta ttcaagtgac aaagattgct gactagcgaa aagggtcagg 1491481 aggagccagt tatgtttcgt aatgtaaaag aattaattga gattactaaa gaaaaacaaa 1491541 tattgatctc tgatgtgatg atagctcaag agatggaagt aacagaaaaa acaaaagagg 1491601 acatttttca gcagatggat cataacctgt ctgttatgga agcggcggtt cagaaaggac 1491661 tcgagggagt tacgagccaa acgggcttaa caggcggaga tgccgttaaa ttgcaggcct 1491721 atattcgatc aggaaaaagc ctgtctggcc cgctgatttt agatgctgta tcgaaagccg 1491781 ttgcaacaaa tgaagtaaat gcagccatgg gaaccatctg tgcgacaccg actgcaggtt 1491841 ctgccggtgt ggtgcccggt acgttatttg ctgtaaaaga aaagctgaat ccaacaagag 1491901 aacaaatgat ccgctttttg tttacagccg gggctttcgg atttgtcgtg gccaataacg 1491961 caagcatttc cggcgccgcc ggaggatgtc aggcagaggt tggatcagct tcaggcatgg 1492021 cggctgcggc tattgttgaa atggcaggag gaacacccga acaaagcgcg gaagccatgg 1492081 ccattacatt aaaaaatatg ctaggcctcg tgtgcgaccc tgttgcaggg cttgttgagg 1492141 tgccttgcgt gaaacggaat gcgatgggcg cgtcaaatgc gatgattgct gctgatatgg 1492201 cattggcggg cattacaagc cgtattccat gtgatgaggt tatcgatgcc atgtataaaa 1492261 taggccaaac gatgccaact gcacttagag aaacaggcca gggcggttta gcggcaacac 1492321 cgacaggaag agaattagag aaaaaaattt tcggaggagc gctaggttca cgtgaaacaa 1492381 catcagcaaa ctagtatagc taacattaag ggtattgggc cggaaacaga aaaaacattg 1492441 aatgaactcg gtatttatga catttctgat cttctgaatt atttccctta tcgctatgat 1492501 gactacgagc tgagggattt agaagaagta aagcatgatg aaagagtcac agtcgaaggg 1492561 aaggttcatt cagagccttc tcttacctat tacggaaaaa aacgaaacag gctgacattc 1492621 aggcttctgg tcggccacta tttaatcaca gccgtatgtt ttaaccggcc ttatttgaag 1492681 aagaagcttt cgctcggctc tgtggtgacg gtttcaggta aatgggacaa gcaccgccaa 1492741 accatctctg ttcaggagtt gaaaaacggg ccgcatcaag aagacaaaag cattgaacca 1492801 gtgtattctg tgaaagaaaa tgttaccgtc aaaatgatga ggcgctttat tcagcaggcg 1492861 ctgacccaat atgcagactc acttcctgat cctcttccgg aaaagctaag aaaaagctat 1492921 aaactgcctg actattatca agcgttaaaa gcaatgcacc agcctgaaac aagggaagca 1492981 ttaaagcttg ccagacggcg gtttgtttat gaagaatttt tgttgtttca gttgaaaatg 1493041 caggcgttcc gaaaggcgga aagagagcag acacaaggga tacggcagcg tttttcaaac 1493101 gaagaactca tgagatttat caaaagcctc ccgtttcccc tcacaaacgc ccagtcacgc 1493161 gttcttcgcg aaataacagc agacatgtct tctccataca gaatgaaccg tcttcttcaa 1493221 ggggacgttg gatcaggaaa aacggcagtc gccgccattg cactgtatgc cgcgatccta 1493281 tccggatacc aaggagcgct catggtgccg acagaaattc tggccgagca gcatgctgat 1493341 tcgctcgttt cgctatttga aaaatgggac gtcagcgttg ctcttttgac aagctctgtt 1493401 aaaggaaagc ggcgaaaaga actgcttgag cgtcttgcgg cgggtgagat tgatattctt 1493461 gtaggaaccc atgctttaat ccaagacgag gtggagttta aggcgttgag tctcgttatt 1493521 actgatgaac agcacagatt tggagttgag cagcgcaaaa agcttcggaa caaagggcag 1493581 gatcccgatg ttctctttat gacagccact ccaatcccaa gaacattagc gatcacagta 1493641 ttcggtgaaa tggatgtatc tgtcattgat gagatgccgg ctggacgaaa gcgaattgaa 1493701 acctattggg taaaacatga catgcttgat cgtattttgg catttgtcga aaaagaatta 1493761 aagcaaggca ggcaggctta tatcatctgt ccgctgattg aagaatcaga taagcttgat 1493821 gtgcaaaacg ccattgacgt gtacaatatg ctttctgata tttttcgggg aaaatggaat 1493881 gtcggcctta tgcatggaaa gctgcattcc gatgaaaaag atcaggtcat gagagaattc 1493941 agcgcaaatc actgtcaaat tctcgtatca accactgttg tggaggttgg cgtaaatgtt 1494001 ccgaatgcaa caattatggt gatttatgac gccgaccgtt tcggactatc acagcttcac 1494061 cagctgcgcg gccgtgttgg acggggtgag catcaatctt tctgtattct gatggctgat 1494121 ccaaaatcag aaacagggaa agaacggatg aggatcatgt cggagaccaa tgacggtttc 1494181 gagctgtctg aaaaggatct ggaactgaga ggtcccggtg atttcttcgg gaaaaaacaa 1494241 agcggaatgc cggaatttaa agtggcggac atggttcatg attacagagc gcttgaaacg 1494301 gcaaggcagg atgctgcgaa tcttgtggct tctgacgcgt tctggaagga gccggaatac 1494361 gctgtgttaa gagatgaatt gctgaagagc ggagtaatgg acggggaaaa attaagctga 1494421 gtatcagaag tttttggtgt tcagccagaa acaatcgttg cattccaatc tatgaaatta 1494481 tatactacta ttagtaccta gtcttaattg tccggatggt gtttagatat gagaagaaat 1494541 aagagagaac gccaggaatt acttcagcag acgattcaag caaccccctt tattacagat 1494601 gaagaactag cgggtaaatt cggggtgagc atccagacga tacgtttgga ccgcttagag 1494661 ctttccatac ctgaactgag agaaagaatt aagaacgtgg cagagaaaac acttgaggac 1494721 gaagtgaagt ccctgtcact tgatgaagtt atcggagaaa ttattgacct tgagctggat 1494781 gatcaggcga tatccatttt agaaataaaa caggagcacg tgttcagccg gaatcagatt 1494841 gcgagaggac accatttatt tgcacaggcg aattctttgg ccgttgcagt cattgatgac 1494901 gagctggcgc tgactgcaag tgcagacatc cgctttacaa gacaggtaaa gcagggtgaa 1494961 cgtgtcgtag caaaagcgaa agtgacggct gtcgaaaaag aaaaaggaag aacggttgtc 1495021 gaagtgaaca gctacgttgg cgaagaaatt gttttttctg gacgctttga catgtatcgt 1495081 tcaaaacatt cataaaggtg gagcatgcat gagaatagct gtagatgcaa tgggaggaga 1495141 ccacgctccc aaagctgtta ttgacggagt tataaaaggt atagaggcat ttgatgatct 1495201 ccatatcaca cttgtcggtg acaaaacaac gatagaatca catttaacaa ctacatcaga 1495261 tcgcatcacg gtgctgcacg cagatgaagt gattgagcct acggatgaac cggtccgtgc 1495321 cgtgcgaaga aaaaagaact catctatggt tcttatggcg caggaggttg cggaaaacag 1495381 agctgacgcc tgcatttcag cgggaaatac cggtgcatta atgacagccg gtctctttat 1495441 tgtcgggaga attaaaggaa ttgaccgtcc ggcgcttgct ccgacacttc cgactgtttc 1495501 gggagacgga tttcttctcc ttgatgtcgg cgccaatgtc gatgccaaac cggagcacct 1495561 cgttcaatat gccatcatgg gttctgttta ttctcagcaa gtgcgcggtg tcacttcacc 1495621 gagagtcgga cttttaaatg tcggaacaga agataaaaaa ggaaacgaac tgacgaagca 1495681 gacgtttcaa attttaaaag aaacagcaaa catcaatttt atcggaaacg tggaagcgcg 1495741 agacctttta gatgatgtgg cggatgttgt agtaacagac ggctttaccg ggaatgttac 1495801 actcaaaacg ctggaaggct ctgcgttgtc aatttttaaa atgatgagag acgtaatgac 1495861 gtctactttg acatccaagc ttgcagcagc tgtgctgaaa ccaaaattga aagaaatgaa 1495921 aatgaaaatg gagtattcga attatggcgg agcaagtctt tttggcttaa aagcgcctgt 1495981 gatcaaggcg cacggctctt cagattcaaa tgctgtattc catgcgattc ggcaagcaag 1496041 agagatggtc agccaaaatg tggctgcgct cattcaggaa gaagtgaaag aagaaaaaac 1496101 agatgagtag tctggaggtt tttacatcat gagtaagatt gcatttttat tcccgggtca 1496161 gggatcacaa tttatcggca tgggaaaaga gctttatgag caggtgcctg ctgcaaagcg 1496221 tctgtttgat gaagccgatg aaacgttgga aacaaaactc agctcgctta tttttgaggg 1496281 ggatgctgaa gaattaacac ttacatacaa tgcgcagcct gctttgctta cgacaagcat 1496341 cgctgttctt gagaaattta aagaatctgg cattacacct gatttcacag caggacacag 1496401 ccttggtgaa tattctgcac tggttgcggc tggcgctctg tctttcaaag atgctgttta 1496461 tactgtcaga aagcgcggag agtttatgaa tgaagcggtg ccggctggcg aaggagcaat 1496521 ggctgcgatt ctcggcatgg atgctgaagc attaaagcaa gtaaccgata aagtcacaga 1496581 ggaaggcaac cttgtacagc ttgcgaatct caactgtcct ggccaaatcg tcatttccgg 1496641 aacagctaaa ggggttgagc ttgcatctga actggcaaaa gagaacggcg caaaacgcgc 1496701 aattccgctt gaagtaagcg gtccgttcca ttctgaactg atgaaaccgg ctgctgaaaa 1496761 gctgaaagag gtattggacg cctgtgacat aaaagacgct gacgttccgg tcatctcaaa 1496821 tgtttctgct gacgtgatga ctgaaaaagc agatatcaaa gaaaaactta ttgagcagct 1496881 ttactctccg gttcgttttg aggaaagcat taacaagctg atcgcagagg gtgttacgac 1496941 ttttattgaa atcggtcccg gaaaagtgct ttcaggcctt gtgaaaaaag tgaatagacg 1497001 gttaaaaaca attgctgtat cagatccgga aacgatcgag ctggcaattc aaacgcttaa 1497061 ggaggagaat gataatgctt aatgataaaa cggctattgt cactggcgca tcccgcggaa 1497121 tcggccgctc aatcgccctt gatctggcaa aaagcggagc aaatgttgtc gtgaactact 1497181 ccggcaatga agcgaaagca aatgaagtgg tagatgaaat caaatcaatg ggcagaaaag 1497241 caattgctgt aaaagcggat gtatcaaatc ccgaagatgt acaaaacatg ataaaagaaa 1497301 cattgtctgt tttttctacg attgacattc tggttaataa tgcgggaatt acaagagaca 1497361 atctcatcat gagaatgaaa gaagacgaat gggatgacgt cattaacatt aacctgaagg 1497421 gtgttttcaa ctgcacaaaa gctgttacaa gacaaatgat gaaacagcgt tcaggccgca 1497481 ttattaacgt atcgtctatc gtcggcgtca gcggaaaccc tggacaagcc aactacgtgg 1497541 ctgcaaaagc cggcgtcatc ggtttaacca aatcttctgc taaagagctc gccagccgaa 1497601 atattacggt aaacgcaata gcgccaggat ttatctcaac tgatatgaca gataaacttg 1497661 caaaagacgt tcaagacgaa atgctgaaac aaattccgct cgcgcgcttt ggtgaaccta 1497721 gcgatgtcag cagtgttgtc acgttcctag cttcagaggg agctcgttat atgacaggcc 1497781 aaacgcttca tattgacggc ggaatggtga tgtaagtttt ttctcgaaaa tttcatcgta 1497841 gtttctctag ttttttaaaa acgaatccac tataatactt gaggggaggt gaattgctat 1497901 ggcagacaca ttagagcgtg taacgaaaat catcgtagat cgccttggcg ttgatgaagc 1497961 agacgtcaaa cttgaagctt ctttcaagga agacttaggt gctgattccc tagatgtagt 1498021 tgagcttgtt atggaacttg aagacgagtt tgatatggag atttctgacg aagatgctga 1498081 aaagattgca acagtcggcg acgctgtgaa ctacatacaa aaccagcaat aagctgatgc 1498141 taaaagtccc gccgaaacgc ggggctttag ccctttattc gtgcagttat tacagcatgc 1498201 cgcttttacg cgcgctgtat ccggtttagt cagagaagcg cggtgaacct gatgtgccta 1498261 tggaggttac tatgtcaaaa cactcacatt ataaagataa aaaaaagttc tataaaaaag 1498321 tagaacaatt taaagagttt caagaacgga tttcggttca ctttcaaaat gaaaagcttt 1498381 tgtatcaagc atttacacat tcatcttatg tgaatgagca tcggaaaaag ccgtatgaag 1498441 ataatgaaag gcttgaattt ttaggtgacg ctgttttgga actgacgatc tccagattct 1498501 tatttgccaa atacccggct atgagtgaag gagatttgac gaaattgaga gccgcaattg 1498561 tttgcgaacc gtctctcgtt tcattggctc acgagctgtc attcggcgat cttgtcctgt 1498621 tgggtaaagg cgaggaaatg acaggcggaa gaaagcgtcc tgctctattg gcggatgttt 1498681 ttgaggcatt tatcggagcc ttgtaccttg accaaggatt agagccggtc gaaagtttct 1498741 taaaagttta tgtgttccct aaaattaacg atggtgcttt ttctcatgtg atggatttca 1498801 aaagccagct gcaggaatac gtgcagcggg acggcaaagg ctctctggag tataaaatct 1498861 ccaacgaaaa aggacctgcg cacaaccgtg aatttgaagc catcgtatct ctaaaaggtg 1498921 aaccactcgg agtcggaaac ggccgttcaa agaaagaagc cgaacagcac gctgctcagg 1498981 aagctttagc taaattgcaa aaacaccata cgaaacaata aaatccccct tatgactcag 1499041 ggggatttca gtatgtatgc cgtcttattt gaccaatgtt tatgatagaa ttgaaatact 1499101 tattacataa ggaggatcgc tatgttcctc aaacgtttag acgttatagg atttaaatca 1499161 tttgcagaac ggatttccgt agacttcgtt aaaggcgtga cagcagttgt cgggccgaac 1499221 ggaagcggaa aaagcaacat cacggatgcc attcgctggg ttctcggcga acaatcggca 1499281 cgctctcttc gcggcggaaa aatggaagac atcatttttg ctgggagtga ttcaagaaag 1499341 cgattaaatc tagctgaagt tacgcttact cttgataatg atgatcattt cttgccaatt 1499401 gacttccacg aggtgagtgt cacaagacgt gtgtacagat caggtgagag tgagtttctg 1499461 attaacaatc agccatgccg cttgaaagat attattgatt tatttatgga ctctgggctt 1499521 ggtaaagaag cattttctat tatcagccaa gggaaagtgg aagagatcct gagcagcaaa 1499581 gcggaggatc gccgcagtat ctttgaagaa gcggccgggg tgcttaaata taaaacgaga 1499641 aagaaaaaag cagaaaataa actgtttgag acacaggaca atctaaatcg ggtagaagat 1499701 atattacatg agcttgaagg acaggttgaa cctcttaaaa ttcaagcttc aatagcgaaa 1499761 gactaccttg agaaaaagaa agagctggag catgttgaaa ttgcgctgac tgcctatgat 1499821 atcgaagagc tgcatggtaa atggtcgact cttaaagaga aagtgcagat ggcaaaagaa 1499881 gaagagcttg ctgaatcgtc tgctatttct gcgaaagaag caaagattga ggatacaagg 1499941 gacaaaatac aagcgcttga tgagtcagta gatgagctcc agcaagtttt actggtaact 1500001 agtgaagagc tggaaaagct tgaaggccgt aaagaagtcc tgaaagaacg aaagaaaaac 1500061 gctgtgcaaa accaagaaca gcttgaagaa gccatcgttc agttccagca aaaagaaacg 1500121 gttctgaaag aagagctttc gaagcaggaa gctgtcttcg aaacgcttca ggctgaggtg 1500181 aagcagttaa gggcgcaagt aaaagaaaaa cagcaggctc tcagtcttca caatgaaaat 1500241 gtcgaagaga aaatcgagca gctgaaaagt gattattttg agctgttaaa cagccaggct 1500301 tcgatacgca acgaactcca gcttcttgat gaccagatgt cccaatccgc tgtcacattg 1500361 cagagacttg cggacaacaa tgaaaagcac ctgcaggaac ggcatgatat ttctgcgcgt 1500421 aaagccgcat gtgaaacgga atttgcccga attgagcagg agattcacag tcaagtcggt 1500481 gcatatcgtg atatgcagac aaaatatgag cagaaaaagc gccaatacga aaaaaatgaa 1500541 tccgctctgt atcaggcata ccaatacgtt cagcaagcga gatcaaaaaa ggacatgctt 1500601 gagacgatgc agggagattt ctccggcttt tatcaaggtg ttaaagaagt gctgaaagcg 1500661 aaagagcgcc ttggcggaat tcgcggagcg gttcttgagc tgatttctac agaacagaag 1500721 tatgaaacgg ccattgaaat agcgctcggc gcttctgctc aacacgtcgt gaccgacgat 1500781 gaacaatctg cccgcaaagc gattcaatat ttaaagcaga attccttcgg ccgggcgacg 1500841 tttctgcctc tttctgttat tagagaccgc cagcttcaaa gccgtgacgc ggaaacagcc 1500901 gcccggcatt catcatttct cggggttgcc agtgaacttg tcacatttga tcctgcgtat 1500961 cgaagcgtca tccagaatct tcttggaacc gttctgatca cagaggactt aaagggtgca 1501021 aacgagcttg cgaagcttct cgggcaccgg taccgcatcg taacccttga gggagatgtt 1501081 gtgaaccccg gtggttcaat gacgggcggc gcggttaaaa agaaaaataa ctccctcctt 1501141 ggaagaagcc gggagctaga agatgtgacg aaacggctcg ctgaaatgga agagaaaacg 1501201 gcactgcttg aacaagaggt caaaaccctt aagcactcca ttcaggatat ggagaaaaaa 1501261 ctggctgact taagagaaac cggggaaggc ttaaggttaa agcagcagga tgtgaaaggc 1501321 cagctgtacg aacttcaagt tgccgagaaa aatatcaata cccatttaga gctctatgat 1501381 caagaaaaat ctgctctgtc agaaagcgat gaagagagaa aagtgcgcaa acgcaagctt 1501441 gaagaagagc tctctgccgt atctgaaaag atgaaacagc ttgaagagga catagacaga 1501501 ctgacaaaac aaaaacaaac gcaatcctca acgaaagagt ctctctccaa cgagctgact 1501561 gagctgaaga tcgcagcggc caaaaaagag caggcttgca agggggaaga ggacaacctt 1501621 gccagattaa agaaagagct cactgaaaca gagcttgcgt taaaagaagc aaaagaagac 1501681 ttaagcttct taacgtcaga gatgtcatct agcaccagcg gcgaagaaaa gctggaagaa 1501741 gcagcaaaac ataaattgaa tgacaaaacg aaaacgatcg aactgattgc attaaggcgc 1501801 gatcagcgca tcaagcttca gcatgggctt gatacgtatg agcgtgagct gaaagaaatg 1501861 aaacgcctgt ataaacaaaa aacaacgctc ttaaaagacg aagaagtcaa acttggacga 1501921 atggaagtcg agcttgataa tttactccaa tacttacggg aggaatacag cttgtccttt 1501981 gagggggcaa aagagaaata tcagcttgaa actgatccag aggaagccag aaagcgcgtg 1502041 aagctgatta aactcgcaat tgaagagctg ggtaccgtga acctcggaag catagatgag 1502101 tttgagaggg tcaacgaacg gtacaagttt ctgtcggaac aaaaagaaga tttaacagaa 1502161 gcgaaaaata ccttgttcca agtgattgaa gaaatggatg aagaaatgac gaagcgcttt 1502221 aacgacacat tcgtccaaat ccgctcacac tttgatcaag ttttccgctc cttattcgga 1502281 ggagggcgag ctgaactgag gctcaccgat cctaacgatc tgcttcattc aggagtcgag 1502341 attatcgctc agccgccggg gaaaaagctg caaaacttaa acctcctgtc aggcggagag 1502401 cgtgcgctta ctgctatagc gctcttattc tcaatcctaa aggttcgtcc agtgccgttt 1502461 tgcgtccttg acgaagtaga ggctgcgctc gacgaagcga atgtgttccg atttgcgcag 1502521 tatttaaaaa aatacagcag cgatactcag tttattgtga ttacccacag aaaaggaacg 1502581 atggaggaag cggatgtgct ttatggcgta accatgcagg aatccggtgt ttccaaggta 1502641 atttcagtta agctggaaga aacaaaagaa ttcgttcagt aacgaggaaa gaggttaaaa 1502701 gatgagcttt tttaaaaaat taaaagagaa aatcacaaaa cagacagatt ccgtatctga 1502761 aaagtttaag gatggccttg aaaaaacaag aaactccttt caaaacaaag tgaatgatct 1502821 tgtatcccgt taccgtaaag tggatgagga tttcttcgaa gagcttgaag aggttcttat 1502881 cagcgcggat gtcggtttta caaccgttat ggaattaata gatgagctga aaaaagaagt 1502941 caaacgcaga aatattcaag atccaaagga agtccagtca gtgatttctg agaaactggt 1503001 cgagatttat aacagcggag atgagcaaat ttcagaactg aacatccagg atgggcgttt 1503061 aaacgtaatc cttctggtag gtgtaaacgg cgtcgggaaa acaacaacga tcggaaagct 1503121 tgctcataaa atgaaacaag aaggaaaatc tgttgtactt gccgccggag acacttttag 1503181 agcgggagcc attgaacagc tggaagtatg gggagagcgt acaggagtgc ctgtcattaa 1503241 gcagacggca ggaagcgatc cggcggctgt catctacgat gctgttcatg ctgcgaaagc 1503301 aagaaatgcc gatgtattaa tttgtgatac ggcagggcgt ctccaaaaca aagtaaatct 1503361 catgaaagag cttgaaaaag taaaacgtgt tatcgaaaga gaagttcctg aagctccgca 1503421 tgaggtgctg cttgcccttg atgccacgac cggccaaaat gcaatggctc aggcaaaaga 1503481 attctctaaa gcaacaaatg ttaccggcat tgctttaacg aagcttgacg gtacggcaaa 1503541 aggcggtatc gtccttgcga ttcgcaacga gcttcacatc ccggttaaac tagtcggttt 1503601 aggagaaaaa gttgatgacc ttcaggaatt tgatccagaa tcctatgtgt acggactctt 1503661 ttcagattta gtggaaaaag ccgacgatta agaaaaaggc cccaacatct tggggccttt 1503721 ttctttttta tcttcttact tgataggcga aatgataaag gctgttatca gtggatacca 1503781 gtcttgactc accagaaaaa actctgaatg ggatgatgtc atagtaatga acggaaacag 1503841 atgtgtaata cgtatagtaa ccagcagctg gccccaaata cattggaacc tcaaatgttc 1503901 cgtttgcatc agtcgttcct gaagcagttt gtgttgtgtt tccgaccttc gtgtccgctt 1503961 caaatcttac gggcgcgttt ggcactggct gtccgttttg gtcgagtaat ttgccgctta 1504021 ctgtaatatt gtacttgact cgccaatatt gaccttgtcc gtaattgatt ttaccgtata 1504081 cccctccatc tgtgctgata tttgtgattg aggccttata aggtgcctca gcagcgtctg 1504141 cttgctgtgc cgggaaacct attgtaaaca gggctgccag acataacata aacaataaac 1504201 cgattttttt cataaaaatc ctccttaaaa tagggttcat atacaatatc ggaataaatt 1504261 ggatgatatt tagcgtattt tggaaaagtt aatcgccgct ttgacaagat aaaaacttga 1504321 cagtgtcatt aaaaccgtgt aaactaagtt atcgtaaagg gatttgactt aacaaagggg 1504381 agagctcaaa tgtcactcga aaagacaacg agaatgaatt atctgtttga tttttatcag 1504441 tcgttgttga cgtcaaaaca gaagagctat atgtcgcttt attatttgga cgatttctcc 1504501 ctaggcgaaa tagccgaaga atatgaggtt tcaagacaag ctgtttatga taacatcaaa 1504561 cgaacagaag caatgcttga acaatatgaa gaaaagctgc tccttttgaa aaagtttcag 1504621 gagcgtaaag agatgtttaa taagctgaag gagcttgctt ccggttcaaa agaagaggaa 1504681 gaaattacag ctctgattga agcgcttgag aaattagatt aggaggcggc aaactatggc 1504741 atttgaagga ttagccgacc gactgcagca gacgatttct aaaatccgcg gaaaagggaa 1504801 agtcagcgaa caagatgtaa aagagatgat gcgtgaggtc cgtcttgcgc tgcttgaggc 1504861 tgacgttaac tttaaagtag tcaaggattt tgtcaaaaaa gtaagtgaac gcgctgtagg 1504921 ccaagacgtc atgaaaagtc tgacgcccgg ccagcaggtc attaaagttg ttcaagagga 1504981 actgactgag ctgatgggcg gcgaagagag caaaatcgcc gtcgcaaaaa ggccgccgac 1505041 tgttattatg atggtcggtc tccaaggtgc cggtaaaacg acaacaagcg gtaagcttgc 1505101 gaatctgctg cgcaaaaagc ataatcgcaa accgatgctg gttgctgccg atatttaccg 1505161 cccagccgca attaagcagc tggaaacact cggcaaacag cttgatatgc ctgttttctc 1505221 tcttggcgat caggtcagtc ctgtagaaat agctaaacag gctattgaga aagccaagga 1505281 agaacattat gactacgtca ttttggatac ggcagggcgc ttgcatatcg accatgaact 1505341 gatggatgaa ctgaccaacg tcaaagaaat cgcgaatccg gaagaaattt tcctggttgt 1505401 cgattcaatg accggtcagg acgctgtgaa tgttgccaaa agctttaatg aacagctcgg 1505461 tttaaccggt gttgtgttga ctaagctgga tggagacaca cgcggcgggg ctgcgctttc 1505521 tattcgcgct gtcacaaaca cgccaattaa gtttgcaggt ttgggcgaaa agcttgatgc 1505581 gttagagccg ttccatcctg aacgcatggc atcaaggatt ctcggcatgg gcgacgtgct 1505641 gacattgatt gaaaaagcac aggccagcgt tgatgaagac aaagccaaag agctggaaca 1505701 aaaaatgaga acgatgagct tcacattgga cgattttctg gagcagctcg ggcaagtcag 1505761 aaacatgggg ccgcttgatg agcttctgca aatgatgccg ggtgcaggta aaatgaaggg 1505821 cctgaaaaac atccaagttg atgaaaaaca gctgaatcat gtggaagcaa tcatcaaatc 1505881 aatgactgtt cttgaaaaag aacagccgga tattatcaat gccagccggc ggaagcggat 1505941 tgcaaaagga agcgggacat ccgtacagga agtcaaccgt ctgcttaagc agtttgatga 1506001 aatgaaaaaa atgatgaagc agatgacaaa catgtcaaaa ggcaagaaaa aagggtttaa 1506061 gctacctttt atgtaatcgg ttatacatga taaaaccgtt gttaagaaaa aacactttac 1506121 aaacactttt atcattgtta atatactatc ttgttgaaat attttcggag gtgctagtaa 1506181 aatggcagta aaaattcgtt taaaacgtat gggagcaaaa aaatctcctt tctatcgtat 1506241 tgttgtagca gattctcgtt caccacgtga cggccgtttc atcgaaacag tcggaactta 1506301 caacccggtt gcaaaaccag cggaagtaaa aattgacgaa gagcttgctc ttaaatggct 1506361 tcaaactgga gcgaaaccat ctgatacagt tcgcaacttg ttctctagcc aaggaatcat 1506421 ggaaaaattc cacaacgcta aacaaggcaa gtaatgactg atcaacactt ggaagatttg 1506481 attgtccaca ttgtgacgcc gcttgttgat catccagatg acattcgcgt cataagagaa 1506541 gaaaccgatc aaaagattgc gctgcgctta tctgtccata agtcagatac cggtaaagtt 1506601 atcggaaagc aaggccggac tgcaaaagcg attcgaacag ctgtatttgc agctggcgta 1506661 cagtcttcta agaaagttca atttgaaata tttgactaaa agggagaggg ccggcacctc 1506721 cccttttttt acacgcaaaa aaagggtaaa ctgatagaag cttaggcaaa atagaaaagc 1506781 ctggacgagt aaaagtttta aaagcgggga gcttggtgcg atgcaaatta ttcaccgtgt 1506841 agccgttatg caagtcttaa ccgagcgcag taaagaaaag cttttagctt cttttgctga 1506901 gaagaaacaa atgcttgaac gagaatgcag ccagctctat tttcagctta gaaaacatga 1506961 gaaagaacag caaaacccta atatgattga acaatttaaa aaggcaatag aaaagcgaaa 1507021 agatgatata aaaatcattg attttcaaat tgctcaagta catacattgc cgcttggcag 1507081 tgagttgaaa gaaaaggaag tcgatgcgct gctgacgatt gaagccgggg atgactggca 1507141 tgagaaaaca gcagcgaaca ccatcgtcat aaaagacgga aaagtaattg aaattcgcca 1507201 gaggtgatca tatgacaaag cgatggttta atgtaggcaa aatcgtaaat acccacggaa 1507261 tcaaaggcga agtgcgggtg atttcaaaaa cagattttgc cgaagaacga tacaagccgg 1507321 gaaacacgct gtatttgttt atggacggcc gtaacgaacc agtggaggta acggtaaaca 1507381 cacatagact gcataagcaa tttcatctcc tgcagtttaa agaaagacaa aacctaaatg 1507441 aagtagaaga gctgaaaaac gcaatcatta aagttcctga agaagaatta ggagagctga 1507501 atgagggtga attttatttc cacgaaatta ttgggtgtga agtatttact gaagaaggcg 1507561 aactcatcgg aaaggtcaaa gaaattttga cgcctggagc caatgacgtt tgggtcatcg 1507621 gacgaaaagg aaaaaaagac gcactcattc cttacattga atcagtggtt aaacatatcg 1507681 atgtcaggga aaagaaaatt gagattgaac tcatggaagg gttaatagac gaatgaaaat 1507741 cgattttttg acgctgtttc ccgaaatgtt tgaaggcgtg ctcggctcat cgattcttca 1507801 aaaagcccag gaaaaagatg cggtgcagtt tcaagtcgta aatttccgag agtactctga 1507861 taacaagcac aatactgttg atgattatcc ttatggcggc ggggcaggca tggttctcaa 1507921 gccccagcct gtttttgacg cggtcgagga cctgacatca aaggcagccg ctgctccgcg 1507981 tattatcctc gtatgcccgc aaggtgagcg ttttacccaa aaaaaagccg aacaattagc 1508041 taaggaagag catttgctgt tcatttgcgg ccactatgaa ggctatgatg aacgcattcg 1508101 cgagcacttg gtaacggatg aaatatcaat tggcgacttt gttctgacgg gcggtgagct 1508161 ccctgcaatg atgatcgcag acagtgtggt cagactgctt ccgggtgtac tgggtaaaga 1508221 ggcttcccat attgaggatt ccttcagcac cggactttta gagcacccgc attatacaag 1508281 accggcagat tacaaaggtt taaaagtgcc tgaaacactc ttgtcaggaa accatgcaaa 1508341 aattgaagaa tggcggaata aagaatcgat cagaaggacc tacctaagac gtccggatct 1508401 gttgaaagac cacccgctta cagagcagca aagaaagtgg atttctgaat gggaaaaaga 1508461 atagatttta ttgcataggc tatgaaattg tgataagata ctacttgtgg cttaagcggg 1508521 cttatccgct gcaagcttga aaacgatgtt ccgctgtgcc ggtttttgtg gccaagagca 1508581 tctgttggaa ggagttgaaa acgatgcaaa aactaattga agatatcaca aaagaacagc 1508641 ttcgtactga tcttcctgcg ttccgtcctg gtgacacttt acgtgtacac gttaaagttg 1508701 ttgagggtaa ccgtgagcgt atccagatct ttgaaggtgt tgtgattaag cgtcgtggtg 1508761 gtggaatcag cgaaacgttc acagttcgta agatttctta cggtgttggc gttgaacgta 1508821 ctttcccagt acacacacca aaaatcgcga aaatcgaagt tgtacgttac ggtaaagtac 1508881 gccgtgctaa actttactac ctgcgtgaac ttcgcggaaa agcggctcgt attaaagaga 1508941 tcagacgata atgataacga acgaaaagag cttgttacct gtaacaagct ctttttttat 1509001 acagaatttg aaaatgccgg acaggcatcg taaaatacat aaaggacaac aatgaatcat 1509061 gcatactgaa gataaaggcg gtgttcgtgt cacatgacaa ttcaatggtt cccgggccat 1509121 atggcaaaag caagaaggga agtaaccgaa aaattaaaat taatcgatat cgtatatgaa 1509181 ttggtagatg ccagaattcc aatgtcatca agaaacccaa tgattgaaga tattctaaaa 1509241 aacaagccgc gaattatgct gttaaacaag gctgacaaag cagatgcggc agttacacag 1509301 cagtggaaag agcactttga gaaccagggg atccgctctc tgtctattaa ttctgtaaat 1509361 ggacaagggt taaatcaaat tgtgcctgca tcaaaagaga tcctccaaga aaaatttgac 1509421 cggatgcgtg cgaaaggtgt gaagccgaga gcgattcgcg ctttgattat cggcattcca 1509481 aacgtcggaa aatcaacgct catcaaccgg cttgcaaaga aaaacatagc aaaaacggga 1509541 gacagacctg gtattacgac ttctcaacag tgggtcaaag ttgggaaaga attagagcta 1509601 ttagatacac cgggaatttt gtggcctaaa tttgaggatg agcttgtcgg tttgagactg 1509661 gcagtcaccg gggctattaa agactcgatt atcaatttgc aggacgtggc cgtgtttggt 1509721 cttcgttttc tcgaagaaca ttacccagaa cggcttaaag agcgttatgg ccttgatgag 1509781 atcccagagg acattgccga gctgtttgat gcaataggtg aaaagcgggg ctgtctcatg 1509841 agcggtgggc tcatcaacta cgataagacg actgaagtca tcattcgcga tattcgcact 1509901 gaaaagttcg gcaggctgtc atttgaacag ccgacgatgt aaaggcgcgc agaaatgcgg 1509961 gtctttattt tttcttggct gaaccgatac atacagtaag ggagaagaga aagtgaatac 1510021 attaaccgta aaggacatta aagaccgttt gcaggaagtg aaggatgcac aagacccatt 1510081 tattgcccaa tgcgaaaacg acccgagaaa aagcgttcaa acgcttgtag agcaatggct 1510141 taaaaagcaa gcgaaagaaa aagcgctgaa agaacaatgg gtgaatatga cttcctatga 1510201 aaggctggca agaaacaaag gatttcgctt gattgcaggt gttgacgagg tcggccgggg 1510261 gccattggca ggaccagttg tcgccagcgc agtcatcctt ccagaggaat gtgaaatact 1510321 tgggctgaca gactccaaaa agctttcaga gaaaaaacgc gaggaatatt acgagcttat 1510381 tatgaaggaa gcactggcgg tcgggatagg aattgtagaa gctactgtga ttgatgagat 1510441 caatatatat gaagcttcaa aaatggcaat ggtgaaagcg atacaggatt tgtcggatac 1510501 acctgattat ttgcttgttg acgcaatgac acttccgctc gacacggctc aggcgtcaat 1510561 tataaaaggc gatgccaaaa gcgtgtctat tgcggcaggt gcgtgtatcg caaaagtgac 1510621 gagggaccga atgatgagcg cttatgccga aacgtatccc atgtacggct ttgaaaaaaa 1510681 taaaggctat gggacaaaag aacatttgga agctctcgct gcatacggcc caactgaatt 1510741 gcaccgcaaa actttcgctc ctgttcaatc tttcagataa atcaccatgg acaaggaggc 1510801 acctttttaa aatgaacata cgaaatgatg tgcaaaaggc gctgcagcac cttttcgggc 1510861 gtacagccgt cccgcaggaa acatcaaaag taaacgaagc gctaaacggg gagaagcgtc 1510921 tcctcttagg aaaagtgctt cgtttactag gagatcagca tgccctgatc caagtcggca 1510981 atcaaactgt tcagggaaaa cttgaaactc agcttcgtcc tcaggcatac tattggtttt 1511041 cctacgaaaa aaaaacggca gagcaaacag gccgtcttca ggtcgttcaa agctttgatc 1511101 aaaatcctaa aaccattcag gatgcagctg gcaaactttt aaatgctatt tcagtgaaga 1511161 cgtcaaacgc agctctcatg atgacaggag cgatgctgaa aagcaaaaca cccgtaacag 1511221 aaaatgatat caaaacagct gtccgctgga tggacacgct gccttcgcaa gacacaaaaa 1511281 aagcagttga aacggttctc ttcgctttaa agcgtgatct tcccattcac tccgagattt 1511341 tgaatggtgt tcacgctgtg aaatcgcctg ttccgttgca tcagcacgta tcccagctgc 1511401 tacaggcaat cgaccaaaac cctcagcaga gccaaatgat gtcaaagcta aaggaagcag 1511461 tcacggtgct tttaaatagt gaaatcgatg tccatgcaga acggctgatt gataagctta 1511521 tttctttaac cgacaatacg aaagcacctt ctccgacgaa tacagctgga agcagggagc 1511581 ttagcacacc agctggctcc cccggaaaag ccagcctgcc gattgcaaat cacacagcag 1511641 aacagggaag catacaagaa gagcctgtta aaacagcagc agacattcca attaaagaag 1511701 cccgccagct gctggtgaag ctgacggaat ctgctgaaaa aaacagtctc caaattgtga 1511761 aagaagcagc aaattggatt aaagcggctg cttcatcggg tgatagtaag tcacttgcag 1511821 cttcagctgt tttacaggcg gcacaagtca cagatcagga agccgaagtc tttttaaagg 1511881 ctgttcagca gacagcaccc catttggcgg ataaggcaga tgttctttct ttcttatcca 1511941 aagtgaaaac ggcaatcggc gcaagggacg aggttgcgtt cattaaagcg tttgaacaag 1512001 gaagcgcagt cacatctggc gaaatgcaat ccatcaagct ggctctttct gccttaagag 1512061 catcgcatga ggtagccgaa ccagtcaaac aagaagccga tcagcttttt cataaattaa 1512121 atggccagct tttcatgcag caggaccatc catcatacag ccaaattgta atgtcatttc 1512181 cgatgttttc gaagtcaggg gttcaggaca tgactgttct gtttaaagga aagaaagaag 1512241 cggatggaaa gcttgatcct tcccattgcc gccttttgtt tttgctgcag cttgatacac 1512301 taaaagaaac cgtcgttgat tgcttggtac agcaaaaagt catgaccatt acaatagaga 1512361 ctgatttcga gctgcaggct gcgatcgatc cgatggtgcc cgcgcttaaa caggggctaa 1512421 aggaaatggg gtacagcctt tcaggggtaa acgctaaaaa aagggttcac accgaagaaa 1512481 aggcttcaat cgatcaatat ataacaagta tcagtgatca ggaagtggat gtgaaaatat 1512541 gaaagagcag acaccgatca gaaaagctgt tgctctccat tatgacgaac aaaaagacaa 1512601 ggcgccgaga gtgattgcca cagggaaggg ccatgtagct gacaacatta taaaagaagc 1512661 gaaaaaagca ggggtcccga ttcaagaaga tcggaccctt gtcgaattaa tgcgccattt 1512721 gacggtagat gatcaaattc ctgaagctct ttatgaaacg gtagccgaga ttttttcatt 1512781 catttacaaa ttggacgaaa gcgtaaaaaa caaaaaatag ctaaaatatt ccccatcctt 1512841 ctttgaaatt tatgttttta ataaagtaaa agtttgaatg tttagaagga ttaaaagatt 1512901 ttgcatcgaa ctgtagacaa ttcttccagt attattatag aatgaaagcg cagtctattt 1512961 tagttttgtt acataagtta ggaggatggg aaatgaatat ccatgagtac cagggaaaag 1513021 aagtcctcag aaaatatggg gtatctgttc ctgaaggtaa agtggctttt acagcagaag 1513081 aagcagttga gagtgcaaag agcttatcca gctcggttta tgtcgtaaag gctcaaattc 1513141 atgctggcgg tcgaggcaaa gctggtgggg taaaaatagc aaaatcatta gacgaagtaa 1513201 aagcgtatgc cgaagaacta ttagggaaga ccctagttac acatcagacg ggtccggacg 1513261 gccaagtaat aaaacgctta cttattgaag aaggctgcga tattaaaaaa gaatattaca 1513321 tcggtctagt gcttgaccgc gccacttcaa gaatcgtttt aatggcttct gaagaaggcg 1513381 gaacggaaat tgaagaggtt gcggagaaaa caccagaaaa aatcaaaaaa gctgtcattg 1513441 atccagctgt tggccttcaa ggctatcaag ccagagaaat tgcattcgct attaatattc 1513501 caaaagagct cgtgggaaaa gctgctaaat ttatgcttgg actatataaa gcgtttgttg 1513561 agaaagactg ctcaatcgcc gaaatcaatc cgcttgttgt gactggcgac ggaaatgtga 1513621 tggcgcttga tgcaaaattg aattttgaca gcaatgcgtt gtaccgacaa aaggacatta 1513681 tggaatacag agatttggat gaagaagatc cgaaagaaat tgaagcgtcc aaatatgatc 1513741 taagctacat ttcccttgat ggaaatatcg gctgtatggt aaacggcgcg ggacttgcaa 1513801 tgtctacgat ggatattatc aagcattatg gaggagaacc ggccaacttc cttgatgtgg 1513861 gcggcggtgc aaccgcggaa aaagtcacgg aagcatttaa aatcattctt tctgatcaaa 1513921 acgttaaagg gatttttgtc aacattttcg gcggcattat gaaatgtgat gtcatcgcag 1513981 aaggggttgt tgaagcgact agacaagttg gtttgacatt gccgcttgtc gtccgtcttg 1514041 aaggcacaaa cgtggatcta gggaagaaaa tccttagtga atcaggatta aacattacat 1514101 ctgcggaatc aatggctgac ggcgcgcaga aaatcgtatc cttagtttaa gaaagaatga 1514161 aaggcagggg accaaataat gagtgttttc attaataaag atacaagagt tattgtgcaa 1514221 gggattacag gttctaccgc tttatttcat acgaagcaga tgcttgaata cggcacaaat 1514281 atcgttggcg gtgtaacacc tggaaaaggc ggaacagaag cggaaggtgt tcctgtattt 1514341 aatacagtgg ctgaagcagt tcaaacaacc ggcgctaacg cgtctgttat atatgtgccc 1514401 gcaccgtttg cagctgatgc gattatggaa gcggtagatg cggagcttga tctcgtgatt 1514461 tgtatcacag aacatatccc ggttttggat atggtgaagg tcaaacgctt catggaaggc 1514521 aagaaaacga gactgatagg gccgaactgt cctggtgtca ttacgcctga agaatgtaaa 1514581 atcggcatta tgcccggata catccataaa aagggtcatg taggcgttgt atcacgttca 1514641 ggaacattaa catacgaagc ggtgcaccag ctctcagaag cgggtgtagg gcaatctaca 1514701 gctgttggaa tcggcggcga ccctgtaaat ggaacaaact ttattgacgt tttaaaagcg 1514761 tttaacgaag atcctgacac acacgcagtc atcatgattg gcgaaatcgg cggtacggcc 1514821 gaagaggaag cggcagagtg ggtaaaagcc aacatgacaa aaccggtagt cggttttatt 1514881 ggcggtaaaa cagcacctcc tgggaagcgc atggggcatg caggcgccat tatttccggc 1514941 gggaaaggga cagctgatga aaaaatcaaa acccttaatg catgcggaat cgaagttgca 1515001 gagacacctt ctgtcatggg tgaaacctta atcaaggtgc tgaaagagaa gaacttgttc 1515061 gaaacttgta aaacgcatta ataaaaaagg gacagccgtc aaggctgttc ctgctttttc 1515121 taacaaaagg aggtcaatct attggatcag gccgctgtct gcctaacgat ttgcagaatc 1515181 aatcaattat tatccccatc ccttctatta aaatggtgga aagccgatcc gtctatgtcg 1515241 ctgacatcac ccgtgttaca aacggttact cgtgatcaaa taaaagcagc tgcattaaaa 1515301 aacgaaatag aacaatttta tccaaagctc ccgcgtgtac ttgctgctta tcgtgagcaa 1515361 ggcattaaca ccatccctat ttcttcaaag caatatcctt tctggcttaa aagcatttat 1515421 gatccccctg ccgtactgtt tgcaaaaggt gatatgactc ttctttcgaa agggagaaaa 1515481 attggaattg taggcacaag aaatccaaca gcttatggga aacaagttgt caatcatctt 1515541 acaaaagaga tctgtcgtaa aggttgggtg attgtcagcg gactggcgtc tgggatagac 1515601 ggaatgtccc atgctgcaag tattaaggcg aaggggcgga caattggcgt cattgcaggc 1515661 ggatttcaac acatttatcc ccgagaaaac cttcagttag cagatcacat ggctaaacac 1515721 catatcctgc tgtcagagca cccacctgaa actaaacccc aaaaatggca tttccctatg 1515781 agaaaccgta ttatcagcgg actaagtgaa ggcgttattg tcgttcaggg caaagaaaaa 1515841 agcggttcgc tgattactgc ctatcaagca ttggaacaag ggagagaggt atttgccgta 1515901 cccggttcat tgtttgaccc ttacgccgga ggtcctataa aactgatcca gcagggggct 1515961 aaagccatat ggtcagcaga ggatattttc gaggaacttc ctgagagaaa cgttcaatat 1516021 acggaaccct tttgaattat cgtttgacaa acggtattgt aatatttaat aatagtgagg 1516081 atttaaagtt gcatattgtt ttctatttaa ttaatgacgt tcatgataaa gaatgaaatg 1516141 ttgaaagcca aataaagaca gctgcaaaaa taaaattgaa atatcttgaa aagagagaga 1516201 acacctcttg agggggatga aaatgtctga ttatctagtc atcgtggaat cgcccgctaa 1516261 ggcgaaaacg attgaacgtt acttaggtaa aaaatataaa gtaaaagcat caatgggaca 1516321 tgtccgggat cttccaaaaa gtcaaatggg agttgacata gaacagaatt ttgaaccgaa 1516381 atatattacc attcgaggta aaggcccggt attaaaagag ctgaaaacgg ctgcgaaaaa 1516441 agccaaaaaa gtgtatctcg cagctgaccc cgacagagaa ggggaagcga ttgcatggca 1516501 tttggcacac agtcttgatt tagatctcaa ctcagactgc cgtgtggtgt ttaacgaaat 1516561 tacaaaagac gctattaagg aatcgtttaa gcatccccgc atgatcaata tggatttagt 1516621 ggatgcacag caagcgagac gtattttaga caggcttgtc ggatataaaa tcagtccaat 1516681 cttatggaaa aaagtcaaaa aagggcttag cgcaggacgc gtgcaatccg ttgccctccg 1516741 tttgattatt gaccgtgaaa aagagattaa cgactttaag cctgaggaat attggacaat 1516801 tgacggtacg ttcttaaaag gtcaagaaac ctttgaagcg agctttttcg ggaaaaacgg 1516861 caaaaaactt cctttaaata gtgaagctga tgtaaaagag attctttctc agctcaaagg 1516921 gaatcaatat acagttgaaa aagtaaccaa aaaggaacgc aaacgtaatc ctgctttgcc 1516981 ttttaccact tctaccctgc agcaggaagc ggctcgcaag ctcaatttca gagcgaagaa 1517041 aacgatgatg attgcacagc aattatatga aggaattgat ttaggaagag aaggaacggt 1517101 tggtctgatc acgtatatga gaacggattc aacccgtatt tcaaatacgg ctgttgatga 1517161 agcagctgca tttattgatc agacatatgg aaaagagttc ctaggcggaa aacggaagcc 1517221 tgcgaaaaag aatgaaaatg cccaggatgc ccacgaagca attcggccga catcagttct 1517281 tagaaaacca agtgaattaa aagcagtcct cggcagagac caaatgagac tgtataaatt 1517341 aatttgggag cgttttgttg ccagccaaat ggcaccggct gttctcgata caatgagtgt 1517401 cgacctgaca aacaacggtt tgacatttcg tgcaaatgga agtaaagtca agttttccgg 1517461 gtttatgaag gtgtatgttg aaggaaaaga cgatcaaatg gaagaaaaag accggatgct 1517521 gcctgactta caagaaggcg acacggtatt atcaaaagat atagaacctg agcagcattt 1517581 tacccagccg cctccgcgat atactgaggc ccggcttgtt aaaacccttg aagaacgcgg 1517641 tatcggccgt ccatccacat atgctccgac acttgatact attcagcggc gcggctacgt 1517701 ggcattggat aataaacgtt tcgttccgac tgaattaggt cagatcgttc ttgacttgat 1517761 catggagttt ttccctgaga tcattaacgt tgagtttaca gctaaaatgg agagagatct 1517821 tgatcatgtt gaagaaggaa ataccgaatg ggtcaagatt atcgataatt tctacaccga 1517881 ttttgaaaaa cgcgtcaaaa aagccgaatc ggaaatgaag gaagttgaga ttgaaccaga 1517941 gtatgctgga gaggattgtg aattgtgcag ttctccaatg gtatataaaa tgggacggta 1518001 cggtaaattc ttagcttgct ccaacttccc tgactgccgg aacacgaaac cgattgtgaa 1518061 acaaatcggt gtgaagtgcc cgagctgcgg agaaggaaac attgttgagc gaaaatcgaa 1518121 aaagaaacgg gtgttttacg gctgtgaccg ttatccggac tgtgaattcg tatcatggga 1518181 caaaccaatt gaacgaaaat gcccgaaatg cggaaaaatg ctcgtcgaga aaaaactcaa 1518241 aaaaggtata caagtccaat gcgtggaatg cgattataag gaagaaccac agaagtagcg 1518301 gtgagcaggg tcttgctcac cttctttgtg tgttaaaaga aggccttgaa taataaacta 1518361 ggagatgtga aagatgaacc aacaaacagt gaatgtaatc ggagccggac tcgcaggaag 1518421 tgaagcagca tggcagcttg ccaaacgtgg gattcaagtc aaattgtatg aaatgcggcc 1518481 agttaaacaa acgcctgcgc atcatacaga taaatttgct gagcttgtct gcagcaactc 1518541 tcttcgctct aatacacttg ctaacgctgt cggtgtatta aaggaagaaa tgcgtgcgct 1518601 tgattcagcc attatcgctg cggctgacga atgttcggtg cctgccgggg gcgctcttgc 1518661 agtagaccgt catgaatttg ccgcaagtgt gacaaatcgg gtgaaaaatc atccaaacgt 1518721 aaccgttatt aatgaagaag tgactgaaat tcctgaaggc cctactatca tcgcaacggg 1518781 tccgttaaca tctgaatcgc tgtctgccca gctgaaggag ctgactggag aggactattt 1518841 atatttttat gacgcagcgg cgccaattgt agaaaaagac agccttgata tggataaagt 1518901 gtacctgaaa tcccgttatg ataaaggtga agcagcatat ttgaactgcc cgatgacaga 1518961 agaagagttt gaccgttttc atgaagcatt aacatcagca gaaacagtgc cgttaaaaga 1519021 atttgaaaaa gagattttct ttgaaggctg catgccgatt gaagtcatgg caaaacgggg 1519081 taagaaaaca atgcttttcg gtccgatgaa accagttggt ctagagcatc ctgttacagg 1519141 aaaacgccct tatgccgtcg ttcagctcag acaggatgat gctgcgggaa cactttataa 1519201 tattgtagga ttccagacac atttaaaatg gggagaccaa aaggaagttc tcaagttgat 1519261 tccaggactt gaaaatgtag aaatcgtcag atatggcgtg atgcatagaa acacatttat 1519321 taactctcca agcctgttaa agccgactta tcaatttaaa aaccgcagtg atctgttctt 1519381 tgcaggccaa atgacgggag tagaaggata tgtggaatca gctgcctcag gacttgtagc 1519441 aggcattaat gcggcgaagc ttgtattggg agaagagctt gtgatcttcc ctcaggaaac 1519501 agcaattggc agtatggcac attatattac aacaacaaac cagaagaact tccagccgat 1519561 gaatgcaaac tttgggcttt tgaaagaatt gccagttaaa attaaaaata aaaaagaacg 1519621 aaatgaacaa tacgcgaacc gtgcgattga aacaattcaa acaatttcga aaacaatata 1519681 ggtattgatt gcaacctgag cgcgatttgt gataccattt aaaagccctt cctggggagg 1519741 tattaggcat ggagaatgtt aagaatttcg taaagttatt cgttgaatat ttacaaattg 1519801 aaaaaaatta ttcacaatat actattgtga attatgtgga ttcaattgaa gaattcgaga 1519861 ctttcctgcg cgttcaaggt ataaatggat ttgaagaagc tgcatatcaa gatactagga 1519921 tttttttgac agaagcctat gaaaaaggtt tatcgagaag aacaataagc aaaaagatat 1519981 ctgcattaag aagcttttat aagtttctga tgcgggaaaa gcttattgaa gaaaatccgt 1520041 ttcagcttgt tcatctgcca aaacaggaga aacggatacc gaagtttcta tatcaaaaag 1520101 agcttgagga gctgtttgaa gtttcagata taagccagcc ggccggaatg agggatcaag 1520161 cgctgttaga gctgctctat gccactggaa tgagggtcag tgaatgctgt tccataacta 1520221 ttaacgacgt tgatttattt atggacactg tgcttgttca cggtaaaggc aagaagcagc 1520281 gctatatccc ctttgggtct tatgcccgcg aagcgttgaa ggtatacatg aatagcggaa 1520341 gacagtgctt gctgatgaag gcaaaagaac ctcatgatct attattcgta aatcaaagag 1520401 gcggaccgct tacagcccgt ggcatcagac atattttaag cgggcttgtt caaaaagcgt 1520461 caagcacttt acatatccat ccgcatatgc ttcgacatac gttcgccacg catctgttaa 1520521 atgaaggagc ggatttgaga agcgttcaag aactgctcgg gcattccaat ctgtcttcta 1520581 cacagatata cacgcacgtt tcgaaggaaa tgttgagaaa cacatatatg tctcaccatc 1520641 caagagcatt taagaaaaat taaaggaggc cctttatgtc atcttttcat gcgaccacaa 1520701 tatttgccgt acagcataaa ggacgaagcg ctatgtccgg agacggccaa gtaacatttg 1520761 gtcaggctgt tgtcatgaaa cacacggcac ggaaagtgag aaaactgttt aacggcaaag 1520821 ttcttgctgg ttttgcggga tctgttgcag acgctttcac tttattcgaa aagtttgaag 1520881 ctaagcttga agaatataac ggcaacttaa aacgggcggc tgttgagctt gcaaaggaat 1520941 ggcgcagtga taaagtgcta agaaagctcg aagccatgct gattgttatg aatcaggata 1521001 ctttgcttct cgtatcggga acaggcgagg tgatcgaacc agatgacggc attctcgcga 1521061 ttggatcagg aggcaattac gctttggcag cgggaagagc actgaaaaag catgccgggg 1521121 aaagcatgtc tgcaagtgag attgccagag ccgcgttaga aacagcaggc gaaatttgtg 1521181 tttacacgaa cgatcaaatc atactggaag agcttgaata gaaaggactt gaggcgcatg 1521241 gaaaaaaaac cgttaactcc tagacagatt gtagatcggt tagaccaata tattgtcggt 1521301 cagcaaaatg cgaaaaaagc tgtcgccgtg gcattaagaa accgctatag aagaagtctt 1521361 ctggatgaaa agctgaagga cgaggtcgtt ccgaaaaaca ttttaatgat gggtcctacc 1521421 ggcgtcggga aaactgaaat tgccagacga atcgctaagc tttcaggtgc gccatttatc 1521481 aaaattgaag ctactaaatt taccgaagtc ggctatgtag gcagagatgt tgaatcaatg 1521541 gtcagagatc ttgtggagac ttctgttcgg cttataaaag aagagaaaat gaatgaagta 1521601 aaggaacagg cagaagaaaa tgcaaacaaa cgcattgttc gtctgttagt tcctgggaag 1521661 aaaaaacaat ctggtgttaa aaatccgttt gaaatgtttt ttggaggcag ccagccgaat 1521721 ggtgaagatg aggcggagag ccaggaagaa gcaaacatcg aagaaaaaag aaaacgaatg 1521781 gcgcatcagc tggctttagg agagctcgaa gactactatg taacagtaga agtcgaagaa 1521841 cagcagcctt ctatgtttga catgctgcag ggctcgggta tggagcagat gggtatgaac 1521901 atgcaggatg cgctgagcgg attaatgcca aagaaaaaga agcggcgcaa aatgacagtc 1521961 agagaagcca gaaaagtcct gacgaatgaa gaagcaagca aactcatcga tatggatgaa 1522021 gtcggccagg aagctgttca gagagcagaa gagagcggga ttatctttat cgatgagatt 1522081 gataaaatcg caaagaacgg cggtgcatct tcttctgccg atgtttcaag agaaggtgtt 1522141 cagcgggata tccttccgat tgttgaaggt tctaccgttg tcacaaaata tggttctgta 1522201 aaaacagacc atgtattatt tattgcagca ggagcgtttc atatggccaa accgtctgat 1522261 ttgattcctg agctgcaggg gcgtttcccg attcgtgtag aactgaacaa actcacggta 1522321 gacgacttcg tgagaatttt ggttgagccg gataatgcgc tgctgaaaca atatcaggca 1522381 ttattgcaga cagaaggtat atctcttgaa ttttctgacg aagctattca taagattgct 1522441 gaagttgctt atcatgtgaa ccaggacaca gataatatcg gtgcgagacg ccttcataca 1522501 atacttgaac gcctattaga agatttgtcg tttgaagctc cagatgtaac gatggagaaa 1522561 ataacgatta caccacagta tgtcgaagaa aagctcggaa cgatagccaa aaacaaagat 1522621 ttaagtcaat ttatattgtg aaaaatttaa tatgaggaat gtttaggagg attatttatc 1522681 atggctttat tacaaaaaac aagaattatt aactccatgc tgcaagctgc ggcagggaaa 1522741 ccggtaaact tcaaggaaat ggcggagacg ctgcgggatg taattgattc caatattttc 1522801 gttgtaagcc gcagagggaa actccttggg tattcaatta accagcaaat tgaaaatgat 1522861 cgtatgaaaa aaatgcttga ggatcgtcaa ttccctgaag aatatacgaa aaatctgttt 1522921 aatgtccctg aaacatcttc taacttggat attaatagtg aatatactgc tttccctgtt 1522981 gagaacagag acctgtttca agctggttta acaacaattg tgccgatcat cggaggcggg 1523041 gaaagattag gaacacttat tctttcgcgt ttacaagatc aattcaatga cgatgactta 1523101 attctagctg aatacggcgc aacagttgtc ggaatggaaa tcctaagaga aaaagcagaa 1523161 gaaattgaag aggaagcaag aagcaaagct gtcgtacaaa tggctatcag ctcgctttct 1523221 tacagtgagc ttgaagcaat tgagcacatt tttgaggagc ttgacggaaa tgaaggtctt 1523281 cttgttgcaa gtaaaattgc tgaccgtgtc ggcattaccc gttctgttat tgtgaacgca 1523341 ctcagaaagc tggagagcgc cggtgttatc gagtctagat cattaggaat gaaaggtact 1523401 tatatcaagg tactaaacaa caaattccta attgaattag aaaatctaaa atctcattaa 1523461 tcacaaaaag aacccttttt gagggttctt tttttatttc aaataaagga aatcaataag 1523521 ctttatttcc tgggttgaaa gtctttctat gtaataattt taataaattt tgcatttttc 1523581 ttcaaaaagt ttcaaaaatg ccgaaaagaa aggagaaaaa acagaaattc tgctattttc 1523641 aggcttatat caaggcgaga aatgtagttc taacaatcta ggactttata cctagttgca 1523701 aaatagataa ttgtgaggac atttttttac acgaacttca tagactttat gcctgttatt 1523761 tcttacaata agcatatagt tttacaattc tcgacaagga tattgagggt gaaaaaaact 1523821 gaaatggagg taagtggatt tgagcttatt ttctggaacg atacaaaatc ttgaaaatgc 1523881 cttgagcaga gcggatatta agcaaaaagt cataactaat aatatcgcca atatagatac 1523941 accgaactat aaggcaaaaa aagtctcttt ccaaaattta ttagatcaag aatcctcgcg 1524001 tcttgaagcg ataaaaacag actatcgtca tgttgatttt tctgatactg attcgaatta 1524061 ttcaattgtt gcgagcggag atacatcgta tcagcaaaac ggaaacaatg ttgatgttga 1524121 caaagagatg acagaattgg cgcaaaatca aatcaactat caagctttgg ttgaaagaat 1524181 gaacggtaaa tttaattcgc tgaagaccgt attaacagga ggaaaatgat gacagctttt 1524241 catagcttaa atgtttcagc atcggcttta acagctcagc gagtcagaat ggacgttgta 1524301 tcatctaact tagcaaatat ggatacgaca agagctaagc aggtgaatgg agagtgggtg 1524361 ccttacagaa gaaaaatggt ttcccttcag tcaaaaggtg aatcgttctc ttccattctc 1524421 aattctcaaa tgagcggaag cgggaatgct ggaaacggtg tgaaggtttc aaaaattacg 1524481 gaggatgatt cggattttaa tcttgtctat gatccgacag accctgatgc aaacgctgaa 1524541 ggatatgtac aaaagcctaa tgttgatcca ttaaaggaaa tggttgatct tgtcagcagc 1524601 actagatcat acgaggcgaa tgtcacggcg atgaatgcca caaagggaat gctgatgaag 1524661 gcgttagaaa tcggaaagta ggcgaactgt taaacaaggt gaaaaaacga tttaattaag 1524721 gtattagggg gataacaatg caatccttga attatgaaga tcaggtgctt tggacgcgct 1524781 ggaaagagtg gaaagatcct aaagccggtg acgacttaat gcgccgttac atgccgcttg 1524841 tcacatatca tgtaggcaga atttctgtcg gactgccgaa atcagtgcat aaagacgatc 1524901 ttatgagcct tggtatgctt ggtttatatg atgcccttga aaaatttgac cccagccggg 1524961 acttaaaatt tgatacctac gcctcgttta gaattcgcgg cgcaatcata gacgggcttc 1525021 gtaaagaaga ttggctgccc agaacctcgc gcgaaaaaac aaaaaaggtt gaagcagcaa 1525081 ttgaaaagct tgaacagcgg tatcttcgga atgtatcgcc cgcggaaatt gcagaggaac 1525141 tcggaatgac ggtacaggat gtcgtgtcaa caatgaatga aggttttttt gcaaatctgc 1525201 tgtcaattga tgaaaagctc catgatcaag atgacgggga aaacattcaa gtcatgatca 1525261 gagatgacaa aaatgttccg cctgaagaaa agattatgaa ggatgaactg attgcacagc 1525321 ttgcggaaaa aattcacgaa ctctctgaaa aagaacagct ggttgtcagt ttgttctaca 1525381 aagaggagtt gacactgaca gaaatcggac aagtattaaa tctttctacg tcccgcatat 1525441 ctcagatcca ttcaaaggca ttatttaaat taaagaatct gctggaaaaa gtgatacaat 1525501 aatgaatttc atggttagcg agtgaaaaac atgtcaacac tattatggct tttaagcttt 1525561 atgctccacg gcgttcttct gtacgctgtc attatcctgt atacgaggct cgctgcagtg 1525621 aaagaaacag aaaaacagca aaaacagata cttgaagaga cggaaaacac cttggcggca 1525681 tttctgcttg aattaaaaga agaaaatgag aaactgatag aaaataaagc ttcatctgca 1525741 agtcaatcag atgaagaatc ccaaaagtca ggccttcaga cctctgaaac atatcaagag 1525801 cgggatccag tccaagaggc agagaatctt cctgaacata ttgaaggtct gattacagag 1525861 gttgaccgtc gggaagagct cgtaaacagt gaggtccaat catttgaaga ccaggtcata 1525921 gaattatatg aacagggata ttcggcaagt caaattgccc agaaaatgaa gagcggaaag 1525981 acagaaatcg agctattttt aaaatttcgc tccaaaggtg taaaggattc ttgattgtcg 1526041 gataaagctg tgttatatta tgtcttggtg ttaaatacac acgcttaacg atttatgcag 1526101 agggtgctgc aggcggcagt tctgtacaaa aatgacctaa gcggaggaaa aaaaccatta 1526161 tattaggagg aaataacatg tcagtcattt ctatgaagca attgcttgaa gctggtgttc 1526221 acttcggtca ccaaacacgc cgttggaacc caaaaatgaa gcgttacatt ttcacggagc 1526281 gtaacggaat ctacatcatt gaccttcaaa aaacagtcaa aaaagtagag gaagcttaca 1526341 acttcactaa aaatcttgct gctgaaggcg gaaaaatcct tttcgtcgga acaaaaaaac 1526401 aagctcaaga ttctgttaaa gaagaagctc aacgctctgg catgtactat gtcaaccaac 1526461 gctggttggg cggtacatta acaaacttcg aaacaatcca aaaacgtatt aaacgtctta 1526521 aagacattga aaaaatgcaa gaaaacggta cgtttgatgt acttcctaaa aaagaagtcg 1526581 ttcaattgaa aaaagaatta gagcgtcttg aaaaattcct aggcggaatt aaagatatga 1526641 aggatcttcc tgatgcatta ttcatcatcg atcctcgcaa agagcgcatc gctgttgcgg 1526701 aagctcgcaa attaaacatc cctatcatcg gtatcgtaga tactaactgt gatccagatg 1526761 aaatcgatgt tgttatccca gcgaacgatg acgctatccg cgctgttaaa cttctaactt 1526821 ctaaaatggc agatgcaatc ttagaagcga agcaaggcga agaagaagcg gaagttgctg 1526881 aagaaactgc accagaaaca gaaacaacaa ctgcgtaacc tattcaaaag gtgataagag 1526941 ggactgcctt ttatcacctt ttttcaagaa aaatgtgtaa tatacatact cttgtttaaa 1527001 catataagga ggaatacaaa tggcaattac tgcacagcaa gtaaaagaac tgcgtgaaaa 1527061 aactggcgcg ggcatgatgg attgtaaaaa agcgttaact gaaactgacg gagatatgga 1527121 caaagcaatt gaccttttaa gagaaaaagg aattgcaaaa gcagcgaaaa aagctgaccg 1527181 tatcgcagca gaaggttcta ctcttattaa aactgacggc aacaaaggcg ttatcctaga 1527241 agtaaactct gaaactgatt tcgttgcgaa aaacgaaggt tttaaagagc ttcttaacac 1527301 tttagctgac caccttcttg caaacacgcc agctgatgtt gaagaagcaa tgggccaaaa 1527361 aatggaaaat ggctcaactg ttgaagagta catcacaagc gcagttgcta aaatcggtga 1527421 gaaaatcact cttcgccgct ttacagttct tacaaaagac gacagctctg cattcggtgc 1527481 gtaccttcac atgggcggcc gcatcggtgt attaactgtt ctcaacggta caactgatga 1527541 agaaactgcg aaagatatcg caatgcacgt tgctgcagtt aaccctcgtt acatttctcg 1527601 tgatcaagta tctgaagaag aaacaaatca tgagcgtcaa atcttaactc agcaagccct 1527661 ccaagaaggc aaacctgaaa acatcgtagc gaaaatggtt gaaggccgtc tgaacaaatt 1527721 cttcgaagaa atttgtctat tagaccaagc gttcgttaaa aacccagatg aaaaagtgaa 1527781 acaagttatt gcagcgaaaa acgctactgt tcaaactttt gtccgctatg aagttggaga 1527841 aggcatcgaa aaacgtcaag aaaactttgc tgaagaagta atgaaccaag tgaaaaaata 1527901 atggtgaaaa gatttcgcgg ctaagtcgcg tcttttcagg cagtataggg gacacatttt 1527961 gtgttcccta tttttaaaac tatatttaca aacctttttt tctcttgcat aatagaaaac 1528021 ggcaatgttt acacttggag gttatcatgg aaaaaccaaa atacaaacgt atcgtattaa 1528081 agcttagcgg ggaagcattg gcaggagaac agggaaatgg aattaacccg actgtcattc 1528141 aatccattgc aaagcaagtg aaggaaatcg ctgagcttga agtcgaagtg gctgttgttg 1528201 taggcggcgg caacttatgg cgcggaaaaa caggaagtga cctgggcatg gaccgcgcga 1528261 ctgctgacta tatgggaatg ctggcgacag taatgaattc gcttgctctt caagacagct 1528321 tggaaacact cggaatccag tccagagtgc aaacatccat tgaaatgaga caagttgctg 1528381 aaccgtacat aagaagaaaa gcgatacgcc acttagagaa aaaacgtgtc gttattttcg 1528441 ctgcgggcac aggaaaccca tatttctcaa ctgatacgac agctgcactg cgggctgctg 1528501 aaattgaggc agacgttatt ttaatggcta aaaataacgt tgacggtgtg tataatgctg 1528561 atcctagaaa agatgaatca gctgttaagt atgaatcact ttcttatctt gacgttctta 1528621 aagacggcct ggaagtcatg gattcaacag cttcctcttt atgcatggac aatgacattc 1528681 cgcttatcgt cttttctatt atggaagaag gaaatatcaa acgtgccgtt atcggtgaat 1528741 caatcggaac gatcgtgagg gggaaataac gtgtcaaaag aagtattaac tcaaacaaaa 1528801 gaaaaaatgg aaaaagcaat tgctgcttat cagcgcgaat tggctactgt acgcgcaggc 1528861 cgtgcaaatc catcattatt agataaagta acggttgaat attacggagc gcagacacct 1528921 ttaaatcagt tgtcttctat taacgtgcct gaagctcgta tgctcgttat cacgccatac 1528981 gataaaacag caatcggtga tatcgaaaaa gcgattttaa aagctgattt aggtcttaca 1529041 ccaacaagtg acggcaatat gattcgaatt gcaattccgg cactaacaga agagagacgg 1529101 aaagaattag tgaaagttgt aaaaaaatat gctgaagaag caaaagtagc tgttcgtaac 1529161 gttcgccgtg atgctaacga tgatctcaaa aaacttgaga aaaacggaga cattactgag 1529221 gatgaactgc gtgcttccac tgaagacgtt caaaaactga cagatgaata tgtgtcaaaa 1529281 attgacagtg tcacaaaaga caaagaaaaa gaaatcatgg aagtttaatg aaaaactatg 1529341 tacaatagat aatagtgaaa agaccctctc atgtttacag ggggtttttt tgttaatact 1529401 gttgattaca ttgattatca gcagggaatg taaccttttt gggtgacgga ggaatctcat 1529461 gctcaacata ctcaaaaatt ggaagaatca gcaaactgcg gcttccaact tagaacgtta 1529521 tacaaaagaa gacatactta agggagaaat tcccgaacac atcgccatta tcatggatgg 1529581 aaatggccgt tgggctaaaa aacgctctct tcccagaatt gcaggccacc atgaagggat 1529641 gaaggtggta aaaaggacca cgaagctcgc aaacgaatta ggtgtcaaag tactgacatt 1529701 gtatgcattt tcaacagaaa actggaaaag accgaaaatg gaggtcgatt ttttaatgaa 1529761 gcttccggaa gaatttttga atacgtatct tccagagctt gttgaggaaa atgtacaggt 1529821 tcggatcatt ggggatgaaa cggctttgcc ggcgcacaca ttacgtgcga ttgaaaaagc 1529881 tgtacaggac acggcgcaaa acgacggaat gatccttaat tttgctctta actatggagg 1529941 ccgtactgaa attgtcagtg ctgcaaaatc actcgcggaa aaagtgaagg aaggctcttt 1530001 gaatattgaa gacattgatg aatcgctttt ttctacttat ttgatgactg aatctttgca 1530061 ggatcctgaa cttttaattc gaacgagcgg cgagataagg ctgagtaatt ttatgctatg 1530121 gcaggttgcc tacagtgaat ttgtctttac tgacgtcttg tggcctgact ttaaagaaga 1530181 tcacttcttg caggcgttag gagagtttca gcagagaggc cggaggtttg gcggaattta 1530241 gaggatggtg gacatgaaac aaagaatttt gacaggtgtt ctggcagcaa ttgtattttt 1530301 atttttggtt attgtcggga aattgccgtt caccatatta atttatgcta tgggcagtgt 1530361 ggcgcttttt gaacttttac ggatgaaaaa gctgaagctg gtttcactgc cgggtttgat 1530421 cggtctttta ttattgtgga tgttcttatt accaagccag tattcgtttt ttgaagcgga 1530481 cgggatttcc aaaatggaaa tcgctttatt tgcggtactg ctattgctga cttacacagt 1530541 gttggtcaag aacaccttta cttttgatga agtcgggttt attacgcttg cagcaattta 1530601 catcggaatg tgttttcatt attttatcga aatcagaaat cttgaccaat acggattaac 1530661 atacattttt tatgcgtgtg ttgtcatttg gtccaccgat tccggtgcct attttgtcgg 1530721 taaatcgctt gggaagcgga aactgtggcc tgaaatcagt ccgaataaaa cagtggaagg 1530781 gtttgcaggc ggaattgtca tcgcacttgt attggcgacg atttttcagc ttgttgcaca 1530841 acttccgatc ccgtatatct atctgctgtt gatcacgctg tttttgtctg tttttggaca 1530901 actgggagat ttagtggaat ccgccttgaa aagacattac gatgtaaagg attctgggaa 1530961 tattcttccc gggcatggcg gtatattaga ccgttttgac agtttcttgt ttgtcatgcc 1531021 tttcttgtac tttctgcttg cccttttttc ataaaaaagt ctaatatgaa tatgagactg 1531081 atcatgcagc aataagaata ggagtagtgg caactttgaa aaatatttgt cttttaggag 1531141 caacaggatc aatcggcgaa cagactcttg atgtactgcg tgcacatcaa gaccaatttc 1531201 agctggtatc tatgtcgttt ggcagaaata ttgataaggc cgttccaatg attgaggtct 1531261 ttcagccgaa gtttgtctct gtcggtgatc tggatacata tcataaatta aaacaaatgt 1531321 ctttttcttt tgaatgccaa atcgggctgg gagaagaagg actgatagaa gcagcagtga 1531381 tggaggaggt tgacattgtt gtcaacgctt tgcttggaag cgtcggtctt atcccgacat 1531441 taaaggcaat tgaacagaaa aaaacaattg cgcttgcaaa taaggaaact cttgtcactg 1531501 cagggcatat agtaaaagaa catgctaaga aatatgatgt tccgctgctg cctgttgaca 1531561 gtgagcattc agccattttt caagctcttc aaggcgaaca ggctaaaaac attgaacgcc 1531621 tcatcattac ggcatccggc ggaagttttc gggacaagac gcgggaggag ctcgaatcag 1531681 taacggttga agatgcatta aaacatccaa actggtcaat gggtgcaaaa attacaattg 1531741 attcggctac aatgatgaat aagggattag aggtgatcga ggcacactgg cttttcgata 1531801 taccttatga acaaattgat gtggttttac ataaggagag catcatccat tcaatggttg 1531861 agttccatga taaaagtgtg atcgcacagc tcggaactcc ggatatgaga gtccccattc 1531921 aatatgcgct cacttatcct gaccgattgc cattaccaga tgcgaaaagg cttgaattat 1531981 gggaaatcgg cagccttcat tttgagaaag ctgattttga caggttccga tgcttacaat 1532041 ttgcttttga atcaggtaaa ataggaggaa caatgccgac agtgctaaat gcggcaaacg 1532101 aagtagctgt cgctgccttt ttagctggca agataccgtt tttggctatt gaagactgta 1532161 tcgaaaaggc actaacccgc catcaattac tgaaaaaacc gagcctggcg gacattcaag 1532221 aagtggacaa agatacccgg ggatacgtca attcaatact cacataaggt ggtatgttcg 1532281 tgaatacagt tatagcgttt atcattattt tcggaacgct cgttttcttc catgaactgg 1532341 gccatttatt gctagcccaa agagcgggaa ttctctgccg tgaatttgcg atcggcttcg 1532401 gtccaaagat tttttctttc aaaaaaaatg aaacagttta tacgatcagg ctgcttccgg 1532461 tcggcggatt tgttcgtatg gccggcgaag atccggaaat gattgaggtg aaacccggat 1532521 acacggtcgg gcttctgttt aataaggaag atcaagttga gaaagtcatc atcaatcaaa 1532581 aggaaaaata tccggatgct ttagtcattg aagtggaaac agcggatcta gagcatgaca 1532641 tgaagatcac cggttatgaa caggggaaag aggacgaact ttccagcttt actgtcagcg 1532701 aaacatcctt ttttattgta gacggagaag aagtgcagat tgcgccgtat aatcgccaat 1532761 ttggttccaa acctgtatgg cagcggatta aagcaattgc tgcagggccg attatgaact 1532821 ttattttagc ttacgtcatt ttagtgatgc ttgggctgat tcaaggcgta ccgtcaaatg 1532881 aacctatgct cgggcagctg acagacaatg gacgggcggc tgaagcaggg ctaaaagaag 1532941 gggattatat ccaaagcatt aacggagaga aaatgaggtc ttggactgac attgtctccg 1533001 ctgtaaaaga aaacccggag aaagaaatgg acgttgcagt aaaaagagat aacaaaacgc 1533061 ttcatatttc ggtgactccg gaagctgtta aagatgagaa caaaaaaaca atcggacgtt 1533121 tcggttccta tgcgccgact gaaaaaggcg tactctcagc ggttgcttac ggcgcgacat 1533181 caacagttga tgtcaccaaa gccattttaa ccaatctgag caaattagta acaggccaat 1533241 ttaaactcga tatgctgtca ggtcctgtcg gcatatatga catgacagac caagtggcga 1533301 aaacagggat cgtgaactta tttcagtttg cggcgttttt aagcattaac cttgggattg 1533361 tcaacctgct tccgattccg gcacttgacg gaggaagact gttgtttcta tttattgaag 1533421 cgattcgggg caaaccgatt aacagggaaa aagaagcatt tgttgtgttt atcggagtag 1533481 ctttcttaat gcttcttatg ctggttgtca catggaacga tatccagcgg ctgtttttgt 1533541 aaacgaaaag taaatcaatc agaggtgcga agaaatgaga caaagcttga cgcttattcc 1533601 tacgctccgt gaagttccag ctgatgccga agcaaaaagt catcagcttc ttctgagagc 1533661 aggatttatc agacagaata cgagcggggt atacagctat atgcctcttg cgtataaggt 1533721 gattcaaaac attcagcaga ttgttcgaga ggaaatggag aaaattgatg ccgtagaaat 1533781 gctcatgccc gcattgcagc aggcagagac atggcaggaa tcaggcagat ggtatacgta 1533841 tggtcccgaa ctgatgagac taaaagaccg tcatggccgt gaatttgctt taggggcaac 1533901 gcatgaagag gttatcactt cgcttgttcg cgatgaggtt aaatcttata agcgtctccc 1533961 tctgactctt tatcaaattc agtctaagtt cagagatgaa aaacgtcctc gcttcggttt 1534021 gttaagaggc cgcgaattta ttatgaagga tgcgtactct ttccatgcat ctgcagagag 1534081 cctggatgaa acgtatcaaa aaatgtacga ggcctattct aatatttttg cccgctgcgg 1534141 cattaatgta agacctgtta tcgctgattc aggcgcaatg ggaggaaagg atacgcacga 1534201 atttatggca ctttctgcga tcggagagga tacgattgcg tattctgatg aatcacagta 1534261 cgcggctaat atcgagatgg ctgaagttct tcaccaggaa gttccttcag atgaagagcc 1534321 taaagctcta gagaaggttc atacgcctaa cgtgaaaaca atcgaagaac tgactgcgtt 1534381 cttacaggtt tcggctgaag cgtgcattaa gtcagtattg tttaaagctg atgaccgttt 1534441 tgtcttagtg cttgtaagag gggatcatga agttaacgat attaaagtga aaaacttgct 1534501 tcatgcagaa gttgtagagc ttgctacaca tgaagaggtc attcagcagc tcggaacaga 1534561 gccaggcttt gtaggccctg tcggtattca tcaggatgtg gaagtatatg ccgatcaagc 1534621 tgtgaaagca atggttaatg ctgttgccgg ggcaaatgaa ggagatcatc attataaaaa 1534681 tgtcaatgtg aatcgtgacg cgcaaattaa agaatttgct gatcttcgtt ttattaaaga 1534741 aggtgatcct tcaccagacg gcaagggaac gatccgtttt gctgagggaa tcgaagtcgg 1534801 acaagtcttt aagctcggaa cacgctattc agaagcgatg aatgcgacat atttagatga 1534861 aaacggacgc gcgcagccaa tgctgatggg ctgttacgga atcggtgtgt caagaacgct 1534921 ttctgctatt gctgaacagc atcacgacga aaaaggctta atatggccaa aaagcgttgc 1534981 gccgtacgat cttcatattc ttgctttgaa catgaaaaac gatgggcaaa gagagcttgc 1535041 tgaaaagctg tatgccgatt taaaagcgga aggctatgaa gtgctctatg atgaccgtgc 1535101 tgagcgtgcc ggcgtaaaat tcgctgattc agatttaatc ggccttccaa tccgcatcac 1535161 tgtcggaaaa cgagctgacg aaggaatcgt cgaagtgaaa attcgtcaaa ctggtgagtc 1535221 aactgagatt tcagtagacg aattatctgc gtttatcagc aagcagtaat caccataacg 1535281 atttatcaaa aaacatgtta aaatagaaat aatagaaggt acctcattgc ctgaggtacc 1535341 ttcacttatg atgtttttag ggagggatac tgtcttaatg gaacagttat cagtaaacag 1535401 aaggcagttt caaattcttc tgcagcagat taatatgaca gatgatacct tcatgacata 1535461 ctttgaacat ggcgagatta aaaagctgac aattcacaaa gcttctaagt cttggcattt 1535521 tcattttcaa tttaaatctt tgctgccttt tcaaatatat gacacattaa caacgaggct 1535581 gacgcaatcg tttgcccaca tagcaaaagt gacatcttca attgaagttc aggatgccga 1535641 ggtcagtgaa agtatcgttc aagactactg gtcacgctgc attgaagaac tgcagggcat 1535701 ttcgccgccg attatcagtc ttttaaacca gcaaaaaccg aagctgaagg gcaataaact 1535761 gattgtcaaa accaaaacag atacagaagc ggctgcgcta aagaacaaat acagttccat 1535821 gattcaagca gaataccgtc aatttggctt tccggatctt cagcttgatg ctgaaatatt 1535881 tgtatccgag caagaagttc aaaagtttcg ggagcaaaag cttgcggaag accaagagcg 1535941 ggctatgcag gccttgattg aaatggagaa gaaagataaa gaaagtgatg aagaccaagc 1536001 accatctggt cctcttgtta tcggttatca aattaaagat aacgaggaaa tccgaacact 1536061 tgacagcatc atggacgaag aacggagaat tacggtccaa ggttatgtgt ttgatgtgga 1536121 gacgcgcgag ctgaagagcg ggcgcacgct gtgtatcttc aaaattacag actatacaaa 1536181 tagtattttg atcaaaatgt ttgcacgtga aaaagaagat gcggcgctga tgaagtctct 1536241 gaaaaaagga atgtgggtaa aagcacgcgg aagcattcaa aatgatacat ttgtcagaga 1536301 ccttgtcatg atcgcaaatg acgtaaacga aataaaagca aaaacccgtg aagattcagc 1536361 acctgaagga gaaaaaagag tggaattgca tcttcattcc ccaatgagcc aaatggatgc 1536421 tgttacgggt atcggaaagc ttgtcgaaca ggcgaaaaaa tgggggcatg aggccatcgc 1536481 tttgaccgac catgctgtcg ttcaatcctt ccctgatgcg tattctgcgg ccaaaaagca 1536541 tggaattaaa atgatttacg ggatggaagc gaatctcgtg gatgatggcg tgccaattgc 1536601 ttataatgcc gcacatcgtc tgctcgaaga agaaacatat gttgtttttg acgttgagac 1536661 gacaggattg tctgctgtat acgataccat tattgagctg gctgcagtaa aagtaaaagg 1536721 cggagaaatt attgataaat ttgaggcgtt tgcgaacccg catcgtccgc tttccgccac 1536781 aatcatagag ctgacaggga tcacagatga tatgctacaa gacgctccgg atgtcgtaga 1536841 tgtaataaga gatttcagag aatggattgg cgatgatatt cttgtcgctc ataatgcaag 1536901 ctttgatatg ggattcttaa atgtagccta taaaaaactt cttgaagtcg aaaaagctaa 1536961 aaacccagtc attgatacgc ttgaacttgg acgttttctc tatccggaat ttaagaacca 1537021 ccggttgaac acactttgta aaaagtttga tatcgagctc acacagcatc accgtgcgat 1537081 ctatgatact gaggcaaccg cttatttgct tctgaaaatg ctgaaagacg cagctgaaaa 1537141 aggtattcag taccatgatg agttgaatga aaatatgggt cagtccaatg cttatcaaag 1537201 atcaagaccg tatcatgcaa cattacttgc cgtgaacagc acgggactta aaaatttatt 1537261 taagcttgtg tcactttctc atattcatta tttttacaga gtgccgcgta ttccgagatc 1537321 tcagcttgag aaatacaggg aagggcttct gatcggttct gcttgtgaca ggggagaggt 1537381 ttttgaggga atgatgcaaa aatcgcctga agaggtggaa gatatcgcgt cattctatga 1537441 ttaccttgag gttcagccgc ctgaagtgta tcgtcacttg ctggagcttg aactggtccg 1537501 tgatgaaaaa gcgctgaaag aaattattgc gaatatcacg aagctggggg aaaagcttaa 1537561 taaaccggtt gttgctacgg gaaatgttca ttacttgaat gatgaggata aaatctacag 1537621 aaagatttta atatcctcac aaggcggggc aaatccgctg aataggcatg aactgccgaa 1537681 agtgcatttc agaacgacag acgaaatgct tgaagctttt tctttcttag gtgaagaaaa 1537741 agcgaaggag atcgtagtca ccaataccca aaaggttgct tctttagttg atgacatcaa 1537801 gccgattaaa gatgatttat atacgccgaa aatcgaaggc gctgatgaag agatcagaga 1537861 aatgagctat cagcgtgcaa gaagcattta cggggaagag ctgcctgaaa ttgtcgaagc 1537921 gcggattgaa aaagagttaa agagtattat tggccacgga tttgctgtta tttacttgat 1537981 ctctcacaaa cttgtaaaac gttcactaga tgacgggtat ctcgttggtt cccgtggttc 1538041 cgtaggatct tcattagttg cgacacttac tgagattact gaggtaaacc cgctgccgcc 1538101 gcactatgtt tgtcctgagt gccagcattc tgagttcttt aatgacggtt ctgtcggttc 1538161 tggttttgac ctgcctgaca agacatgccc tcattgcgga acgcctttga aaaaagacgg 1538221 ccatgatatt ccatttgaaa cgttcttagg atttaaaggg gacaaagtac ctgatatcga 1538281 tttgaacttc tcaggggaat atcagccgca agcacacaat tacacaaaag tattgttcgg 1538341 agaagacaat gtatatcgtg cgggaacaat aggcacggtg gcagaaaaaa cagcctacgg 1538401 ttatgtaaaa ggctatgccg gagacaacaa tcttcatatg cgcggtgccg aaatagatcg 1538461 gctcgtacag ggatgcacag gtgtaaaacg tacaactgga cagcaccctg gcggtattat 1538521 cgtagttccg gattatatgg atatttatga tttttcaccg atccagttcc cggcagatgc 1538581 cacaggttca gagtggaaaa cgactcattt tgatttccac tccatccatg acaacctgtt 1538641 aaaacttgat attctcggac acgatgaccc gactgttatt cggatgcttc aagacttaag 1538701 cggaatagat ccgaaaacaa ttccgacgga tgatcctgaa gtgatgaaga tcttccaggg 1538761 aaccgaatca ctcggtgtga ctgaagaaca gattggctgt aaaacgggca ctcttggaat 1538821 tcctgaattc ggaacccgat ttgtccggca gatgcttgaa gatacaaagc cgaccacttt 1538881 ttctgagctc gttcagattt caggcttgtc tcacggaact gatgtatggc ttggcaatgc 1538941 acaggagctc atccacaata atatttgtga gctgagtgag gttatcggct gccgtgatga 1539001 cattatggtt tatttaatct atcaaggcct tgagccgtcc cttgccttta aaatcatgga 1539061 attcgtgcgt aaaggaaaag gattaacgcc tgaatgggaa gaagaaatga aaaataacaa 1539121 tgtcccagac tggtatattg attcctgtaa aaagattaaa tacatgttcc cgaaagccca 1539181 cgccgcggca tatgtcttaa tggcagtccg cattgcttac tttaaagtgc atcatgctct 1539241 tttgtattat gcggcttatt ttaccgttcg tgcagatgac tttgatattg atacaatgat 1539301 caagggctct acagcaatca gagcggtaat ggaggatata aacgctaaag gacttgatgc 1539361 ttcaccgaag gaaaagaacc ttctgactgt tttagaatta gcgcttgaga tgtgtgagag 1539421 aggctattca ttccaaaaag tcgatttata tcgctccagc gccacagagt ttattattga 1539481 cggcaacagt cttattccgc cgtttaactc tattccaggg ttagggacga acgctgcttt 1539541 gaacattgta aaagctcgcg aagaaggcga attcctctca aaagaagatt tgcaaaagag 1539601 agggaaagta tcaaaaacga ttttagagta cttagatcgc catggctgtc tggagtcact 1539661 gcctgatcaa aaccaattgt cactgttcta atatggaaag cagaatttct cagaaattct 1539721 gcttctatgc atacataagc gcaaaaagtg ccatcgtaat attagagttt ctgtcacttg 1539781 cttaggtatg aaggtaagcg tatatccatt tgcaataaaa atatggttat ggtatagttt 1539841 tattggaaat gctaacgatt accgaggcaa agagtgggga aacccgctct tttgtattga 1539901 acaggagaat tttgtctcga catgttcatc gtttactttt tagcccctgc tcttttgaag 1539961 cagggttttt atgcagagtg acgagacgaa tatgagatcg acagcacaag gaggaagaac 1540021 atgagcaaaa aagtgactga caccgttcaa gaaatggctc agccaatcgt agacagcctt 1540081 cagctggaac tcgttgacat tgaatttgtc aaagagggcc aaagctggtt ccttcgcgtg 1540141 tttattgatt ccgatgacgg tgtggatatt gaggaatgtg ccaaagtaag cgaagcttta 1540201 agcgaaaagc ttgatgaggc agacccaatc agccaaaatt actttcttga agtctcatct 1540261 ccaggagctg agcgtccgct aaagaaaaaa gccgatttcg aaaaatcact aggaaaaaac 1540321 gtatacatta agacgtatga gcctattgac ggcgtaaaag tgtttgaagg tgaactggct 1540381 gaatttgatg gacaaacagt gacagttgag atcacgatca aaacaagaaa gaaacggatc 1540441 aatattccgt atgaaaagat agctaatgca agattagctg ttacattcta atgaatacaa 1540501 atgttttaag gggggagacc gttaaatgag cagtgaatta ttagatgctc tcacgattct 1540561 tgaaaaagaa aaaggcatca gtaaagaaat tatcatcgaa gcaatcgaag ctgcgttaat 1540621 ttctgcttat aagcggaatt ttaatcaagc gcaaaatgta cgggtggatc taaaccgtga 1540681 aactggctcc atccgtgtat ttgcaagaaa agatgtcgtt gacgaagtat acgaccagag 1540741 attagaaatc tcaattgaag aggcacaggg catccatccg gaatatatgg tcggcgatgt 1540801 cgtcgaaatc gaagttacac ctaaggattt cgggcgcata gctgctcaaa cagcgaagca 1540861 ggtcgtcaca cagcgtgtgc gcgaagctga gcgcggtgtg atttattctg aatttatcga 1540921 ccgtgaagaa gacatcatga cagggatcgt ccagcgtctg gacaataaat ttatctacgt 1540981 gtctttaggc aaaatagaag ccttgctgcc ggttaatgag caaatgccga atgaaagcta 1541041 caagccccat gaccgcatta aggtatatat cacaaaagta gaaaaaacaa cgaagggtcc 1541101 gcagatttat gtgtcaagaa cacatccagg cctgttaaag cgtttgtttg aaattgaagt 1541161 gcctgaaatt tatgatggaa ctgtcgagct aaaatctgtt gccagagaag ccggcgaccg 1541221 ttcgaaaatt tctgttcgca cagatgatcc tgacgttgat cctgtcggtt catgcgtagg 1541281 gcctaaaggc cagcgtgtgc aagcaatcgt caatgaatta aaaggtgaaa aaattgacat 1541341 tgtcaactgg tccagtgatc ctgtagaatt tgtcgcgaat gcgctcagcc cttccaaagt 1541401 gcttgatgtc attgttaatg aagaagaaaa agcgacaact gttattgttc ctgattacca 1541461 gctgtctctg gcaattggaa aaagaggaca aaacgcacgc ttagctgcta aactgacagg 1541521 ctggaagatt gatattaaga gcgaaacgga cgcaagagaa cttggaatct atccgagaga 1541581 acttgaagaa gatgatgagc cgctctttac ggagcctgaa actgctgaat cggatgaata 1541641 agaggtgact ttaggtgaat aaacacaaaa agatcccatt acgcaaatgt gtagtgactg 1541701 gtgaaatgaa gcctaaaaag gaactgatcc gagttgtacg gtcgaaagaa ggcgaaatct 1541761 cagtagaccc gaccggaaaa aagaatgggc ggggtgctta tttaacgctg gataaagagt 1541821 gcatcttagc agcaaaaaag aaaaacactt tgcaaaatca atttcaatca caaatcgatg 1541881 accagatttt cgatgaattg ctggaactgg cggaaaaggt gaaaaaataa aatgtctgga 1541941 atggaatggt ttcccttgct gggtctggcc aatcgagctc gtaaggtcgt gtcaggcgaa 1542001 gacttggtaa taaaagaaat caggaatgcg cgtgcaaagc ttgtcctgct tacagaggat 1542061 gcatcatcta acacagcaaa aaaagtaact gacaagtgca attattataa agtcccttat 1542121 aaaaaagtcg agagtcgcgc ggttcttgga cgctctatcg gtaaagaagc ccgtgtcgtt 1542181 gtcgccgtca ctgaccaagg ttttgcgaat aagctgatca gcttgctcga ttaatatttt 1542241 tgggggtgaa cgaatggcta aaatgagagt atacgaatat gcaaaagcgt taaatgtttc 1542301 aagtaaggaa attttgaccg cactgaagaa catggattta gaagtgaata atcacatggc 1542361 catgcttgaa gaaaaggcca ttaaaaagct agatgccaaa tataaaaaag gcggcgcagc 1542421 tgctaaatct caaaagccag cagaaacgaa caaaaacaaa cagccacaag gggttaatca 1542481 gcaatcagct ggaaatcaac caaataaaat tcgagacgga aagaagaatg acgtgcagaa 1542541 taatcaattt aacaaaaaca agaagaataa caacaacaaa aaaaataaac gcaacaacaa 1542601 caataataaa aaccaacatc agcaaaagcc tgtaaagccg aaaaaagagc ttcctgagaa 1542661 aattacattc tctggcactt taacagttgg cgcacttgct gaagagcttg gcaaagagcc 1542721 ttcagaactc attaaaaagc tgatgcttct tggcgtaatg gcaaccatta accaagagct 1542781 tgataaagac acaatcgaac tcattgcatc agaatatggt gttgaaacag aagaggtcat 1542841 tgtgcttgaa gaaacagagc tggaaaaata cgaagagcct gataatgaag aggatcttga 1542901 aattcgtcct cctgtcgtga caatcatggg ccacgttgac catgggaaaa caacgcttct 1542961 tgacagcatc cgtaaaacaa aggttgttga aggggaagca ggcggaatca ctcagcatat 1543021 cggcgcttat caaattgaag agaacggcaa gaaaatcacg ttcttggata caccgggcca 1543081 cgccgcattt acaacaatgc gcgcacgcgg tgcagaagta actgatatta cgattcttgt 1543141 cgtagctgcc gatgacggtg tcatgccgca aacagttgaa gcgattaacc atgcaaaagc 1543201 agcagaggtt ccaatcatcg ttgctgtgaa taaaatagat aaagaatccg caaaccctga 1543261 ccgtgtaatg caagaactga cggaatacgg acttgtccct gaagcttggg gcggagaaac 1543321 catttttgtg ccgctttccg ctttaactgg aaaaggcatt gatgagctcg ttgaaatgat 1543381 tttgcttgtc agtgaggtag aggaactgaa agcgaatccg aatcgtcagg caaaaggaac 1543441 ggttattgaa gctgaactcg ataaaggcag agggtcagtc gcgacgttgc tcgtacagac 1543501 tggaacactg catgtcggtg atccgatcgt agtcggcaat acatttggcc gtgtccgtgc 1543561 aatggtcaac gacattggcc gccgtgtgaa aactgccggc ccgtcaactc cggttgaaat 1543621 taccggtttg aatgatgtcc ctcaagcggg agaccaattc cttgtcttta aggatgaaaa 1543681 aacagctcgt tctgtcggtg aagcccgtgc ttcgaaacag cttgaagagc agcgcagcga 1543741 taaagcgaag ctcagtcttg atgatttatt tgagcaaatt aagcaaggtg atgtaaaaga 1543801 catcaacctc atcgtaaaag ctgacgttca aggatctgct gaagctttaa cggctgcact 1543861 tcaaaaaatt gaagtagaag gcgttaaagt gaaaatcatc catacaggcg ttggtgcgat 1543921 tactgaatca gacattatct tggcatctgc ttccaatgca attgttatcg ggtttaatgt 1543981 gagaccggac ggaaatgcta agagtacggc tgaagctgaa aatgtagata ttcgacttca 1544041 ccgtatcatt tacaaagtaa tcgacgagat tgaagctgcc atgaaaggta tgcttgatcc 1544101 tgaatatgaa gaaaaagtaa ttggtcaagt agaagtacgc caaacattca aagtatctaa 1544161 aatcggtaca attgccggcg gatatgttac tgaaggaacc attacgcgcg acagcggcct 1544221 ccgtttaatt cgtgacggcg tcgtcatctt tgaaggcgaa gtagatgttc tgaaacgctt 1544281 taaagacgat gtgaaagaag tttcacaagg ctatgaatgt ggtattacaa ttaagaaata 1544341 caatgacatt cgtgaaggtg acatccttga agcgtttgtc atgcaagaaa ttgaaagaac 1544401 gtgatcggat ttgcggagtg tgaatgcatc atttatgatg caggatcgct aaaagaaaag 1544461 cgtgccgttc tgaagcggat tttaaccagg gttcaaaaca agttcaatgt ttcgatttcg 1544521 gagattggct atcaggacac ctggcaaaga accagcttcg gaatcgccgc tgtttcttcc 1544581 tctcgcgttc aaacagaaaa agaactgcag cgcgtcctag cgtttatcga ttcttttcct 1544641 gaaattgaac ggacgatcac taggacagag tggttttaac ttagaggtga ttgaattgag 1544701 tatgagagca aaccgtgtcg gcgagcaaat gaaaaaagaa ctcggtgata ttatcagccg 1544761 caagctgaaa gacccgagaa ttggttttct gacagtaacg gatgtacgtg tatcaggtga 1544821 tttgcaaatt gcaaaggtgt atatctcggt tctcggtgac gagaaaaaac gggaagaagc 1544881 gctgaaaggg ctggcaaaag cgaaaggatt tatccgatcc gaaatcggca gccgcatcag 1544941 acttcgaaaa acgcctgaaa ttgaatttga gttcgatgaa tcaatcgatt acgggaatcg 1545001 gatcgaaaca ctgattcacg aattacattc agagaaacca tctgaataaa aaaagagagg 1545061 ataggcgtat atcgtctgtc ctctttcttc gtttataaga aaaaaactca aaagaaggag 1545121 tgaaaggcaa atggttaacg gagttctcct tttacataaa cctgttggca tgacatcgca 1545181 cgactgtgtc atgaagatcc gaaagctgtt aaaaacaaaa aaagtaggac atacaggaac 1545241 gctcgatccg gaagtatcag gcgtgcttcc gatttgtgta ggaagagcga caaaaatagt 1545301 cgaatactta actgaaaaat ctaaaacgta tgatgcagaa ataacattgg gcttttcaac 1545361 cacaacagag gatcaaaccg gagaaacggt ggaaacaaag cctgtcaatc acgacattga 1545421 taaagcggat gtagaaaagg ttttaaacag tttaaagggg aaacaagaac aaattccgcc 1545481 catgtattcc gctgtaaaag taaacggcaa aaaattatac gaatacgcaa gagcagggat 1545541 tgaagtagaa cgtccgaaac gtatgataac cattgaagac attgccctga caacagagat 1545601 taaacatcat ggagaaaccg caagcttccg gtttacagtg acttgctcca aagggaccta 1545661 tgtaaggacg ctggcggtca tgatcggaga aaagctcgga tatccggccc atatgtctca 1545721 tttaatccgt acggcatccg gagatttttc tctcgacgaa tgctttactt ttgatgaact 1545781 cgaagcacag gcccaatccg gaaccgtgga agagcataca gttcctattg aacgtgcgct 1545841 caatcatttg ccgaaatgga tcataagtga tacattagct aagaaagtag aaaatggggc 1545901 tttgcttgag acgcccgagc agttttctga aatgacaagt ggagaccgta ttgccgtctt 1545961 tactgaatcc ggaacctgct tggcgatcta tttccctcat cctgcaaaaa aagggctgtt 1546021 aaagccggca aaagtattga tgcaaaaaag cgaacaatag aaaaaaggtg accgttctgt 1546081 gaagacgata catattacac atcctcatca tttaataaaa gaggagcagg caaaatcagt 1546141 gatggcgtta ggttattttg acggcgttca tctcgggcat caaaaggtaa tcggcacagc 1546201 gaagcaaata gccgaagaaa aaggtctgac attagctgtg atgacctttc atccccatcc 1546261 ttctcacgtg ttgggcagag ataaggaacc aaaggatctg attacgcctc ttgaagacaa 1546321 aataaaccaa attgaacaat taggcacaga agttctgtat gtcgttaaat ttaatgaagt 1546381 gtttgcttct ctttctccta agcagtttat agaccagtat attatcggcc ttaatgtgca 1546441 gcacgcagtg gcaggctttg actttacgta cggcaaatac ggcaagggaa caatgaagac 1546501 catgccggat gatttagacg gaaaagctgg gtgcacaatg gtagaaaaat taacggagca 1546561 ggataaaaaa atcagttctt cgtatatccg taccgcgctt caaaacggag atgttgaatt 1546621 ggcgaatgtc ttgcttggac aaccttattt tattaaagga attgtcattc atggtgataa 1546681 aagagggcgg accatcgggt ttccgacagc gaatgtcggt ttaaataaca gctatatcgt 1546741 tccgcccaca ggtgtatatg ccgtaaaagc ggaagtgaac ggcgaagttt acaatggcgt 1546801 ttgcaatatt ggctataagc caacgtttta tgaaaagcgc cctgaacagc cttccatcga 1546861 ggtcaatctg tttgatttca atcaagaggt atatggagcc gctataaaaa tcgaatggta 1546921 caaacggatt cggagcgagc ggaaattcaa tggcatcaaa gaattaactg agcaaattga 1546981 gaaagataag caggaagcca tccgttattt cagcaatttg cggaaataac ttgcaacgca 1547041 cgcaaatttt attctaaaat atttgcatat aggcacgatt tttagtatga tagttttcgt 1547101 agtcttaaaa ccattgcttg gcaatccgaa gtcaccgacg gttgctaggt aactggggct 1547161 aaatatgatt tggaggtgaa acaggatggc aattactcaa gagcgtaaaa accaactcat 1547221 caatgagttc aaaacacacg aatctgatac tggatctcca gaagttcaga tcgctatcct 1547281 aactgactca attaacaact tgaacgagca tttacgtact cacaagaaag accaccactc 1547341 acgtcgcggt cttcttaaaa tggtaggtaa gcgtcgtaat cttcttacgt atctgcgtaa 1547401 taaagacgta actcgttacc gtgagttaat taacaaacta ggcttacgtc gataatcgta 1547461 aaaagcggga ggattcccgc ttttttatcg tattaaagcg aaatttctta taacaaatca 1547521 ttgaaatcct tttacatact actttgacat tgatatgttc aattcatttc gttcataata 1547581 ggagtaattg attatttcac acaacgaaga gaggagttcg taattgtatg ggacaagaaa 1547641 aacatgtctt taccatagat tgggccggaa gaacgcttac cgttgaaacc ggccagcttg 1547701 ccaaacaggc aaatggtgct gtgatgatcc gctacggtga tacagcagta cttagtacag 1547761 caaccgcttc aaaagaacct aaaccgcttg atttcttccc tcttactgta aactatgaag 1547821 aaagattata tgcggtaggg aaaattccgg gcggatttat taaaagagaa ggacgtccaa 1547881 gtgaaaaagc ggttcttgcc agccgtttaa ttgaccgtcc gatccgtcct ttgtttgccg 1547941 atggattccg taatgaagtt caagtcatca gcattgtcat gagtgttgac caaaactgct 1548001 cttcagaaat ggctgccatg ttcggttcat ctcttgcact ttctgtatcg gatattccgt 1548061 ttgaaggacc gattgcaggg gttactgtcg gacgcattga tgatcaattt atcattaacc 1548121 cgacagtcga tcagcttgaa aaaagcgata tcaatcttgt cgttgccggc acgaaagatg 1548181 cgattaacat ggtagaagcg ggagcggacg aagttcctga ggaaatcatg cttgaggcca 1548241 ttatgttcgg ccatgaagag attaaacgcc tgattgcatt ccaagaagaa attgttgcag 1548301 cagtcggcaa agagaaatct gaaattaagc tctttgaaat tgatgaagag cttaatgaaa 1548361 aagtaaaagc tttggcagaa gaggatctgc tgaaagccat ccaagttcat gaaaagcatg 1548421 cccgtgaaga tgccattaac gaagtgaaga acgcagttgt ggcaaaattc gaggatgaag 1548481 aacatgatga agacacaatc aagcaagtga agcagatttt atccaagctt gtgaaaaatg 1548541 aagttcgccg cctgattact gaagagaaag taagaccgga cggccgcggt gtcgatcaaa 1548601 tccgtccgct ctcttcagag gttggcctct tgccaagaac gcacggttca ggtctattta 1548661 caaggggaca aactcaggcc ctcagcgtat gtacgctagg tgctctggga gatgtgcaaa 1548721 tccttgacgg cttaggtgtc gaagagtcga aacggtttat gcatcattac aacttcccgc 1548781 aattcagcgt tggggaaaca ggaccgatgc gcggaccggg acgtcgtgaa atcggacacg 1548841 gagcactggg tgagcgtgcg cttgagccag ttattccgtc tgaaaaagac ttcccttata 1548901 ctgtccgtct tgtttcagaa gtgcttgaat caaacggttc tacatctcaa gcaagcattt 1548961 gcgcaagcac acttgcaatg atggatgccg gtgtaccgat taaagcgcca gttgctggta 1549021 ttgcgatggg tcttgtcaaa tcaggcgaac attacactgt cttgactgac atccaaggca 1549081 tggaagacgc gctcggagat atggacttta aagtagcggg aactgaaaaa ggcgtaacgg 1549141 ccctgcaaat ggacattaaa attgaaggcc tttccagaga gattcttgaa gaagcgcttc 1549201 agcaggcgaa aaagggcaga atggaaatcc tcaacagcat gcttgcaaca ttaagcgaat 1549261 caagaaaaga gctttctcga tatgcgccta agatcttaac aatgaccatt aatcctgata 1549321 aaatccgcga tgtcatcgga ccaagcggga aacaaatcaa taagatcatc gaagaaaccg 1549381 gtgttaaaat tgatattgag caggacggca caatctttat ttcctctaca gatgaaagcg 1549441 gcaaccaaaa agcgaaaaaa atcatcgaag accttgtgag agaggttgaa gtcggccaac 1549501 tttacctagg taaagtgaaa cggattgaaa aattcggggc tttcgttgaa attttcagcg 1549561 gaaaagacgg tttggtgcac atttcagagc ttgcgcttga acgcgtaggg aaagttgaag 1549621 atgttgtgaa aatcggagac gagattcttg tcaaagtcac tgaaattgat aaacaaggac 1549681 gagtgaattt atcccgcaaa gcggtgctcc gtgaagagaa agaaaaagaa gaacaacaat 1549741 cttaaatgaa aacataaaag gagcctggga gacccggctt ctttattttg aagcttttca 1549801 aaagcaggcg ggttctacct tgtccttctc cttcataatg tgaggtgagg gggggacaga 1549861 acatgtacaa aaaatttgta ccgtttgccg tttttttatt tctttttttt gtctcatttg 1549921 agatgatgga aaatccgcat gcacttgatt atataggggc aatgaaaaaa gatacggtga 1549981 ctgtcacggc gtcaaaagac ccgttatatg aagaattgct tcaaaaagcg ccggagtacg 1550041 aagttaagcc ccagaatgca agaattgata aagtgtggaa aagcattcca ggctacaatg 1550101 gattaaaggt caatattgaa caatcatata aaaaaatgaa acagcatggt aagtttcggg 1550161 aaaaagattt ggtgtacagt caagtaaaac caagtgttca tcttgagtca cttcagcctg 1550221 agcctattta taaaggaaat cctgacaaac cgatggtggc ttttttaatc aatgtggcat 1550281 ggggaaatga gtatttggaa aaaatgcttc ctattctgca aaagcaccag gttaaagcta 1550341 cgttcttttt agaaggcaat tgggtgagaa acaatgtaca gctcgctaag aagattgcaa 1550401 aagacggaca tgaaatcgga aatcattcat acaatcatcc ggatatgagc aaactgacta 1550461 caggaagaat ttccgagcag ctcgacaaga ctaatgaaca aatagaacaa acgatcggcg 1550521 ttaagccaaa gtggttcgct ccgccaagcg gaagtttcag aaaagcggtt atcgacattg 1550581 cagcagagaa acagatggga acagtcatgt ggacagttga tacaatcgat tggcaaaagc 1550641 cggctccgtc tgtacttcag acgagagtgt taagcaagat acataatggt gccatgattt 1550701 taatgcatcc gactgaccct acggcggaaa gtcttgaagc gctgattaca cagataaaag 1550761 acaaaggata tgcgcttgga acagtcactg aactaatgga tgaaacaaga ctattgaagt 1550821 aacagatgaa ggcagcttgt ctttgaatag gaggaacaaa tttgattaaa cgatatacgt 1550881 gtcaaaatgg tgtaagaatt gtgctggaaa ataacccgac agtccgttct gttgcgatcg 1550941 gcgtatggat cggcacaggt tcgagacatg aaacgccgga gataaacgga atttctcact 1551001 ttttagagca catgttcttt aaagggacga gcacaaaatc tgcacgcgag atagcagaat 1551061 cttttgatcg tattggcggc caggtcaatg cgtttacttc aaaggaatat acctgctact 1551121 atgcaaaggt gcttgacgag catgcgaatt acgcgctgga cgtattagca gatatgttct 1551181 ttcattcaac gtttgatgaa aacgagctga aaaaagagaa aaatgtagta tatgaagaaa 1551241 ttaaaatgta tgaagatgcg ccggacgaca ttgtacatga tttattgagc aaagccactt 1551301 acggcaatca ttctttaggc tacccaattt taggaacgga agaaacgctt gcttccttta 1551361 acggtgactc tctcagacaa tacatgcatg attattatac gccggaccga gtggtgattt 1551421 cggtagcggg caatatatct gacagtttta tcaaagatgt agaaaaatgg ttcgggtcat 1551481 acgaggcgaa aggcaaagcg acaggccttg agaagcctga gttccacacg gaaaaactga 1551541 cgagaaaaaa agaaacagag caggctcatt tgtgccttgg atttaaaggc ttagaggttg 1551601 gccatgaacg tatttatgat ttaatcgtcc tcaacaatgt gctcggaggc agcatgagca 1551661 gccggctgtt ccaagatgtg cgtgaagata aaggacttgc ttattctgtt tacagctatc 1551721 acagctcata tgaggacagc ggaatgctaa cgatttacgg cggaacgggt gcaaatcagc 1551781 ttcagcagct gtcggaaaca attcaagaaa ccctggccac attaaaacgt gacggcatta 1551841 cctcgaaaga actggaaaac agcaaagagc aaatgaaggg aagcttaatg ctgagcttag 1551901 aaagcacaaa cagcaaaatg agccgaaacg gaaaaaatga actgctgctc ggcaaacata 1551961 aaacattaga tgaaattatc aatgaattaa acgccgtgaa cttagagcgt gttaatggcc 1552021 ttgccagaca attgtttacc gaagactatg cattagcact tatcagccct tccggcaata 1552081 tgccgtctta aaaaggaaag cctgccccat aatggagcag gcatttttta atccctttca 1552141 tcatacatag tacaaggggg tgacagacat gcggctcagt gaattatcgg gaaaggaaat 1552201 tgtagacatc aaaagagctg aacggctcgg agtgctcggc cagaccgatt tggaaatcaa 1552261 tgaacaggat ggacagatta cagcactcct cattcccaca gttaagtggt ttggtttgag 1552321 aaagcaaggt catgacattc gtgtcccatg gcaccatatt caaaagatcg gttcagatat 1552381 gattatatta gatgtacctg aggaaatgcc tcctcgacaa gagtaaatag cccaattgac 1552441 tgtgaagcgg gctctaaaga aaacatctga aacatcggct gccggagccg atgttttttt 1552501 atatggaaaa agcgcatctt ttatattcac cggtatttcc ttttgatcat aagatgaagg 1552561 ggagcttaac aactagagat ccagtatata caaagaaggt gaacgtttag aatgttaacc 1552621 ggattgaaaa ttgcagttat cggcggtgac gcaagacagc tcgaaattat aagaaagctc 1552681 actgaacagc aggctgacat ctatcttgtc ggttttgacc aattggatca cggttttacc 1552741 ggggcagtaa aatgcaatat tgatgaaatt ccttttcagc aaatagacag catcattctt 1552801 ccagtatccg cgacaacagg agaaggtgtc gtatcgactg tattttcgaa tgaagaagtt 1552861 gtgttaaaac aggaccatct tgacagaacg cctgcacatt gtgtcatttt ctcaggaatt 1552921 tctaacgcct atttagaaaa cattgcagct caggcaaaaa gaaaacttgt taagctgttt 1552981 gagcgggatg acattgcgat atacaactct attccgacag tagaaggaac gatcatgctg 1553041 gctattcagc acacggatta tacgatacac ggatcacagg tggccgttct cggtctgggg 1553101 cgcaccggga tgacgattgc ccgtacattt gccgcgctcg gggcgaatgt aaaagtgggg 1553161 gcaagaagtt cagcgcatct ggcacgtatc actgaaatgg ggctcgttcc ttttcatacc 1553221 gatgagctga aagagcatgt aaaagatata gatatttgca ttaataccat accgagtatg 1553281 attttaaatc aaacggtact ttctagcatg acaccaaaaa ccttaatatt ggatctggcc 1553341 tcacgtcccg ggggaacgga ttttaaatat gccgagaaac aagggattaa agcacttctt 1553401 gctcccgggc ttccagggat tgtcgctcct aaaacagctg ggcaaatcct tgcaaacgtc 1553461 ttgagcaagc ttttggctga aatacaagct gaggagggga aataaggatg tcgtcattaa 1553521 aaggaaaaag aatcgggttt gggctgaccg ggtcgcattg cacatatgaa gcggttttcc 1553581 cgcaaattga ggagttggtc aacgaaggag ctgaagtccg tccggttgtc acatttaatg 1553641 taaaatctac aaatacccga tttggagagg gcgcagaatg ggttaaaaaa attgaagacc 1553701 tgactggata tgaggccatt gattcgattg taaaggcaga acctcttggg ccgaagctgc 1553761 cccttgactg catggtcatt gcgcctttaa caggcaattc aatgagcaag ctggcaaatg 1553821 ccatgacgga cagcccggtg ctgatggcgg caaaagcgac aatccggaac aatcggcctg 1553881 tcgttctggg tatctcgaca aatgatgctc ttggtttaaa cggaacaaat ttaatgaggc 1553941 tcatgtcaac aaaaaatatc ttttttattc cattcgggca agatgatcca tttaaaaaac 1554001 cgaattcaat ggtagccaaa atggatctgc ttccgcaaac gattgaaaag gcactcatgc 1554061 accagcagct tcagccgatt ctagttgaga attatcaggg aaatgactaa atttacagaa 1554121 aatctttccc aaactaaaaa attcggtcat cacccgcata ttctatggta aaataaaacg 1554181 taaaatcata gtcaaatcaa ttcaatgaag ctgattggcg gaaggagttt tacagatggg 1554241 aagaggttta cacgtagctg ttgtcggagc gacaggggct gtgggacaac aaatgcttaa 1554301 aacacttgaa gacagaaact ttgaaatgga cacacttaca ttgctatctt caaaacgctc 1554361 tgcggggaca aaagtcacgt ttaaaggcca agagctgact gttcaggaag cttctcctga 1554421 gagctttgaa ggggtaaata ttgctttgtt cagcgccggc ggaagcgtat cacaagcatt 1554481 ggcaccagaa gctgtaaaac gcggcgctat tgttatagat aatacgagtg cgttccgcat 1554541 ggatgaaaat acaccgcttg ttgtgccaga agtgaatgag gcagacttgc atgaacacaa 1554601 cggcattatt gccaatccaa actgctctac aatccaaatg gttgcggcac ttgaaccgat 1554661 ccgcaaagca tatggcttaa acaaggtcat cgtatcaact taccaggcag tatcaggagc 1554721 gggtaatgaa gctgtaaaag agctttacag ccaaacacag gcgattttaa ataaagaaga 1554781 aatagagcct gagatcatgc ctgtaaaagg tgacaaaaaa cactatcaaa tcgccttcaa 1554841 cgcgattccg caaatcgata aattccaaga taacggctat acgtttgagg aaatgaaaat 1554901 gataaatgaa acgaaaaaaa tcatgcacat gcctgacctt caagtagcgg ctacatgtgt 1554961 gagactgcca atccaaactg ggcactcaga gtccgtctac atcgaaatag accgtgatga 1555021 cgctacagtt gaagatatta aaaatctatt gaaagaagct ccgggcgtga cacttcagga 1555081 tgatccaagc cagcagcttt atccgatgcc tgctgatgct gtcggcaaaa acgatgtgtt 1555141 tgtaggccgc atccgcaaag acttggacag agcaaacggt tttcatttat gggttgtttc 1555201 tgataaccta ttaaaaggcg cggcatggaa ctctgttcaa attgcagaaa gcctgaaaaa 1555261 actaaacctc gtataaaaga gagaattttc taaagacgaa tagaagagag taaggcgcta 1555321 tcagcctgct ctcttctgtt acgtccgaat aatttggagt gaaaacagtg aagataattg 1555381 ttcaaaagtt cggcggaaca tcagtaaaag atgataaagg ccgcaaactg gctttagggc 1555441 atattaaaga agcaatcagt gaaggatata aggttgtcgt tgtcgtttca gcgatgggcc 1555501 gaaaagggga cccgtatgca acagattctt tgctcgggct gctttacggc gatcagtcag 1555561 cgatttctcc tagggagcag gatttgcttt tatcttgcgg agagactatt tcctctgtcg 1555621 tctttacaag catgctgctt gataacggtg tgaaagcagc tgcgctgaca ggggctcagg 1555681 ctggcttttt aacgaatgat cagcatacta atgcgaaaat cattgaaatg aaaccggagc 1555741 gtttattcag tgtgctcgcc aatcatgatg cggtagtcgt cgcaggcttc cagggcgcaa 1555801 ctgaaaaggg tgatacaaca acaatcggca gagggggcag cgatacgtct gcagccgcac 1555861 tcggagcagc tgttgatgcg gaatacatcg atattttcac cgatgtagaa ggcgtgatga 1555921 ctgctgaccc aagagtggta gaaaatgcaa aaccgcttcc tgttgtgacg tatacggaaa 1555981 tctgcaacct ggcgtatcag ggggccaagg tcatttctcc gcgtgctgtg gaaatcgcaa 1556041 tgcaggccaa ggttccgatc cgcgtccgtt cgacttattc gaatgataaa ggcacattgg 1556101 tgacatcaca tcactcttcc aaggtcggca gtgatgtttt tgaaaggctg attacgggaa 1556161 tcgcccatgt caaagatgtc acgcagttca aagtgcctgc gaaaatcggc cagtataacg 1556221 ttcagactga agtgttcaag gctatggcaa acgctggaat cagtgtcgat ttctttaaca 1556281 ttacacctag tgaaatcgtc tatacggtag ccggaaataa aacagaaaca gctcagcgta 1556341 ttttaatgga tatgggctat gatccaatgg tgacgagaaa ctgcgcgaag gtatcggcgg 1556401 tcggcgcggg cattatgggt gttcccggtg ttacgtccaa aattgtatcg gctctttcag 1556461 aaaaagaaat tccgatcctt cagtcggctg acagccatac gacgatatgg gtgctcgtcc 1556521 atgaagcgga tatggttcct gctgtaaacg ctttgcatga agtgtttgaa ctttcgaagt 1556581 aaatgtgatt gaatcatgat gaggtgaata aaatgaattt cggaaatgtg tctacagcga 1556641 tgattacacc ctttgacaat aaagggaacg tagactttca aaaactgtct acactgattg 1556701 attacttgtt gaaaaacgga acggattctt tagtagtagc gggaacaact ggagaatctc 1556761 cgaccctttc aactgaagaa aaaattgcgc tttttgaata tacggtaaaa gaagtaaacg 1556821 gacgggtgcc cgttatcgct ggtactggga gcaacaacac gaaagattcc attaagctga 1556881 caaaaaaagc tgaggaagcg ggcgtggacg ctgttatgct tgttaccccg tattacaata 1556941 aaccttctca agaaggaatg taccagcatt ttaaagcaat tgcggcagag acatctcttc 1557001 cggttatgct ctataatgtt cctggccgta cggttgcttc tcttgctcct gaaacgacga 1557061 tccgtttggc ggcagacatt ccgaatgtgg ttgcgattaa agaagcgagc ggagacctcg 1557121 aagcgattac aaaaattatt gctgaaacac ctgaagactt ctatgtctat tcaggggatg 1557181 atgctctaac gcttccaatt ctttcagttg gaggtagagg agttgtgtca gtggcgagcc 1557241 atattgcagg cactgatatg cagcaaatga tcaaaaatta tacgaatggg caaacagcta 1557301 atgcggcact gattcatcag aaactgctgc cgattatgaa ggaactgttt aaagcgccta 1557361 atcctgctcc agtcaaaaca gcgcttcagc tgagaggtct tgatgtcggt tctgtgcgtc 1557421 tgcctctagt cccattaact gaggatgaac gtctgagctt aagcagcacg atcagcgaac 1557481 tgtaagaaaa tttcatacag tgaaacaaac gcggtcattc tcacattcag ctgagtttga 1557541 ccgtttcttt tacatattgg ttttccctaa accttctgct ttatcttgtt ttctaaattt 1557601 actttcagtt ataataggaa caagtgatga tggacgggta tgagactagg aggatataga 1557661 ttttgaaaaa gaaaaataca gaaaacgtta gaattatcgc ccttggcggt gtcggagaga 1557721 ttgggaagaa cctttatgtc attgaaattg actcagacat atttgtcgtt gatgccggcc 1557781 ttatgcatcc agaaaacgaa atgctcggta ttgatgtagt gattcctgac atatcatatt 1557841 tgattgaacg ggctgaccgc gtcaaggcaa tctttttaac gcacgggcac gatgaaaata 1557901 tcggcggcgt tttttactta ttaaacaagc tgtccgttcc agtgtacgga acaaaactga 1557961 cgcttgcact gttaagagag aaattaaaac aatacggaca taaccgaaaa actgatttaa 1558021 gagaaattca ctccaaatct gtcattacat ttgaatcaac aaaggtatcg ttctttagaa 1558081 cgattcacag cattcctgat tctgtaggtg tgagctttaa aacatcactt ggatctattg 1558141 tatgcacggg agacttcaaa tttgaccaaa cacctgcact taatcagacg tgcgacattg 1558201 gcgagatcgc caagatcggc aatagcggcg tgctcgctct gctttctgac agtgcaaatg 1558261 cggaacggcc gggttacacc ccttcggaag cggctgtcag cggagaaatt tcggatgcgc 1558321 tgtataattc acagaaccgg gtgattattg ctgttttcgc atccaatatt aaccggattc 1558381 agcaagtcat tcatgcagcg gctcaaaatg gcagaaagat tgccgtagcc ggaaaaaatc 1558441 ttcaatctgt cctgcagctg gcgagaaagt taggatatat tgaagcagat gatgaattgt 1558501 ttatttctgt acaggatgtc aaaaaatatc cgaagcgcga agtggccatt attacagccg 1558561 gaagccaagg tgaaccatta gctgctttga caagaatggc aaacaaagct cacaaacagc 1558621 tgaacattga agaaggggat acggtggtca ttgcgtcaac tccgattccc gggcaggaac 1558681 tcatttactc taaaacagta gatcttcttg cgagagccgg tgcacaagtc atctttgccc 1558741 aaaagcgtgt tcatgtatca ggccacggct cacaagaaga gttaaagctg atgatcaacc 1558801 tgcttaaacc aaaatatttg attcctgtaa acggcgaata cagaatgcaa aaagctcatt 1558861 caaaaatcgc tgaagaaacc ggcatgaagc gcagtgacat cttcttaatt gaaaaaggcg 1558921 acgtcgttga attccgcggc caaaacgtaa aaattgggga taaagttcct tacggcaata 1558981 ttttaattga tggtttaggt gtcggtgata tcggcaatat cgtattgaga gaccgccgct 1559041 tgctttcaca ggacggaatt ttaatcgttg tcattacact tgataaacaa aagaaacatc 1559101 ttgtatcagg accagaaatt atcactcgcg gctttgttta tgtaagagag tctgaaggtc 1559161 ttatcgtaca ggctactgag cttgtacggt ccatcgtgac agaagcgact gaaacatcaa 1559221 atgtcgaatg gtcaacgctg aagcaggcaa tgcgggatgc tttgaaccaa ttcctttatg 1559281 aaaaaacgaa acgtaaaccg atgatcatcc caattattat ggaagtataa tgactgacta 1559341 aagaccggag ctgctccggt ctttattttt tgtccttcaa gccgggattg aatgaagtat 1559401 ctttgttcat aatacaaaga gaaactcgga aaggatgaaa gcgagatgga tcatcgtatg 1559461 gaaaacacag aagaagagcg tcctgaaaaa aatgatgcga aggacagcat tatgaataaa 1559521 atacagcagc ttggtgaaac gacgcttccg cagctgcccc aagatacaaa tattcattgt 1559581 ctgaccatta tcggacaaat tgaaggccat gttcagcttc ctccgcaaaa caaaacaaca 1559641 aaatatgaac atgtcatccc gcagattgtg gcaattgaac aaaatcccaa aattgaaggc 1559701 ttgctgatca tattaaatac tgtcggagga gatgttgaag ctggtcttgc catagcggaa 1559761 atgcttgcat ctttatcgaa accgaccgtt tctatcgtgc ttggcggggg gcattcaatc 1559821 ggcgttccga ttgctgtatc ctgtgattac agctatatcg ccgaaacagc aacgatgacg 1559881 attcatccag ttaggctcac cgggctggtc atcggggtgc cgcaaacgtt tgaatacctg 1559941 gataagatgc aagaaagagt tgttaaattt gtgacaagcc attccaatat aaccgaagag 1560001 aagtttaaag agctaatgtt ttcaaaagga aacttaacac gcgatatcgg aacaaatgta 1560061 gtcggtaagg atgcagttaa atacggattg atcgatcacg caggcggtgt cggacaggca 1560121 atcaataaac tgaatgagct catcgatgaa gcaaggaaag aagaaggacg gatgattcaa 1560181 tgattcttta taccgtgatg cctcaggaaa ttgtgtttgc agaacagaac caagagacaa 1560241 gcgcacatga gcaaattgaa tataaaggtg taccgcttct agtcgaaatg aaagggaatg 1560301 aagcggaagt cattcaaatc atgagcacca atccaatgca ttttctgcat ccggacattt 1560361 caccgggaca aaagctgaaa ttaaacgtat aagaatccaa ccctttttta agggcaaaat 1560421 atgctataat aggggaatcc tacagaaaaa acgcagcctg taaacggctg ctttcttcat 1560481 tatgtatgaa cttacatttt ttaacgcagt aaggtgatga gtgtggcaaa gaaaaaacga 1560541 aaatcaagaa aaaaacaggc gaaacagctc aatataaaat acgagctcaa cggattgctg 1560601 tgtatagcca tttcaattat cgcaatcttg cagctggggg tagtcgggca aacgtttatc 1560661 tatttgttcc gcttttttgc tggagagtgg tttattttat gcttgttagg tttattggtg 1560721 ttaggagtct cactgttttg gaagaaaaaa accccaagcc ttttaacgag acgaaaggcc 1560781 gggttgtact gtattatcgc aagcatattg ctgctttctc acgtgcagct atttaaaaat 1560841 ttgacgcaca aagggtctat tgagtctgca agcgtggtgc gcaatacgtg ggaattgttt 1560901 ttaatggaca tgaatggcag ctctgcttca cctgatttag gcggagggat gatcggtgcg 1560961 ctgctgtttg cggcttcaca ctttttgttt gcgtcgactg gttctcagat catggcaatt 1561021 gtcatgattt tgatcggaat gattttagta acaggacgct cgctgcaaga aacgctaaaa 1561081 aagtggatga gcccgattgg acgttttata aaagaacaat ggttagcatt tattgatgac 1561141 atgaaatcct tcaaatcaaa tatgcagtca tcgaaaaaaa cgaaagcgcc gagcaaaaaa 1561201 caaaaaccgg cccgcaaaaa acagcaaatg gaaccggagc ctcctgatga agagggggat 1561261 tatgaaacag tatcgcctct tattcattca gagccgatta tctcaagctt ttctgatcgt 1561321 aatgaagagg aagagtctcc agttatagaa aagcgcgccg aacctgtgtc gaagccgctt 1561381 caggacatcc aaccggagac aggtgatcag gaaactgttt ctgctcctcc tatgaccttt 1561441 acagagctcg aaaataagga ttacgagatg ccgtcactgg atttgctggc agatccgaag 1561501 cataccggcc agcaggctga taaaaagaat atttatgaaa atgcgagaaa gcttgaacgc 1561561 acattccaaa gctttggcgt aaaggcgaaa gtcacacagg ttcatctcgg accggccgta 1561621 acaaaatatg aagtatatcc tgatgtcgga gtgaaggtta gcaaaattgt caatttaagc 1561681 gatgatttag cgcttgcgct tgctgcgaag gatatcagga tcgaagcgcc tataccaggc 1561741 aaatcagcaa tcggaattga agttccaaac gcagaagtgg caatggtttc gctgaaagaa 1561801 gtgctggagt ctaaattgaa tgacagaccg gatgcgaagc tgttaattgg actcggccgc 1561861 aatatttcag gtgaagctgt attggctgag ttaaacaaga tgccccacct tttggtcgca 1561921 ggcgcaaccg gtagcgggaa aagtgtctgt gtcaacggca ttattacaag tattttaatg 1561981 cgggcgaaac cgcatgaagt gaaaatgatg atgatcgatc ctaaaatggt agagctaaat 1562041 gtctacaacg ggattccgca tttgcttgct cctgttgtaa ccgatccgaa aaaagcgtcg 1562101 caggctttga aaaaggttgt caatgaaatg gagcggcggt acgaattatt ttctcatacg 1562161 ggtacaagaa atattgaagg atacaatgat tatataaaac gcgccaacaa tgaagaagga 1562221 gcgaaacagc cagagctgcc ttatattgtt gtcattgtgg acgagctagc cgatctcatg 1562281 atggtcgctt catctgatgt ggaagattcg attacgagat tgtcccaaat ggcgcgggct 1562341 gccggcatcc atcttattat tgcgacacag cggccatcgg tggatgttat cacaggggtg 1562401 atcaaagcga acattccgtc acgaatcgcg ttcagcgtat cttcacagac ggattcaagg 1562461 accattcttg acatgggtgg cgctgagaag cttcttggcc gcggcgatat gctgttttta 1562521 cctgtagggg ctaacaaacc tgtccgtgtg cagggagcat ttttgtcgga tgacgaagtg 1562581 gagaaggtcg tcgaccatgt gattactcag cagaaagcgc aatatcaaga agaaatgatt 1562641 cctgaggaga cgacggaaac tcattccgag gttactgatg aactttatga tgaagctgtt 1562701 gaattaatcg tcggcatgca gacggcatct gtttcaatgc tgcaaagaag attcagaatt 1562761 ggctatacga gagcggcgcg cctgattgac gcaatggagg aacgcggtgt tgtcggaccg 1562821 tatgaaggca gcaaacctag ggaagtatta ttatcaaaag agaaatatga tgagctctct 1562881 tcttaatgaa gggagttccg ctttctatag ttgtcaataa tgatattatg taaactgatc 1562941 acctttctat ttattttttc gacaaaacat gatatagttg tcccaattgt tcaataattt 1563001 ttatcgaaag tggtttacgg aggggaaaca tgtctacaaa agctgataat cggcacttgt 1563061 atttgaaagt aattgaacga attaaagagg atataaaaaa tgggatctac actgagaagg 1563121 aaaagctgcc ttctgaattt gagctttcca aaaagcttgg tgtcagcaga gcgacgctaa 1563181 gagaagcctt gcggatactg gaagaagagc atgtgattat cagaaggcat ggtgtaggca 1563241 cttttgtcca ttctaagccg ttatttcttt cgggtattga acagctgaac agtgtaacca 1563301 agatgataga acaggcgaat atgacccctg gcacgatttt tctatcatca caagtgctta 1563361 tgccgtctga agatgatacg aagagatttc acttggcaga agggcaagaa cttttttacc 1563421 ttgaacgagt caggacagct gacggacagc cgattgtgta ttgtatagac aaaattccga 1563481 tgaatatttt gccgaattct ttttctcatc agcaagaatc tatgtttgac ctgctagaga 1563541 aaaattcagg ctccgtaatc agctatgcag taactgatat agaaccgatc ggctatcacg 1563601 ataccatttc tccagtgctt gaatgcgatc cggaaacagc tcttttgctg ttaaaacaaa 1563661 cccattacga tcagcacgat aaaccggtgc tttattcttt aaattatttt agagcggata 1563721 aattcagatt tcatgttttg cgtaaacgat tctaaaaacg gacgcctgta tgtgtctgtt 1563781 tttttatttg cactgattca tgtttctttg tacatacttt cattccggtt aacgcaatat 1563841 ataagggatg acaagaaagt gaatgggtga aaatgttgag agagaaaaat ggaatgaaaa 1563901 atattattgc attgtcttct gtcccgcttg tgatgacact cgggaactcc atgctgattc 1563961 ctgttcttcc gatgatggag aaaaagctgt ctgtgacttc atttcaagta tctttaatca 1564021 ttactgtata ttcagtagta gcaattattt gcattccgat tgccggatat ttgtcggatc 1564081 gtttcgggag aaaaaaaata ttgcttccat gcctcctcat tgcaggattg gggggagccg 1564141 tagctgcttt tgcctcgacc tatatgaaaa atccttatgc tatgatcttg gcggggcggg 1564201 ttcttcaagg cattggttct gcaggtgccg ctccgattgt catgccgttt atcggcgacc 1564261 tgtttaaagg agacgatgaa aaggtcagcg cgggtcttgg cgatattgaa accgccaaca 1564321 cgtcagggaa ggtactgagt cccatacttg gagccttact ggcttcttgg tattggtttg 1564381 taccgttttg gtttattccg tttttctgtt tgatcagctt tttgctcgta ttgtttttgg 1564441 tggccaagcc tgaagaagat gaagatgcgc ctgctgtttc tgagtttatt aagagtgtga 1564501 agaaaatttt taaacaggat ggtcgctggc tttatacggt cttcattatc gggtgtgtca 1564561 ttatgttttt gttatttggc gtattatttt atttatcaga tacgctggag aacaagtatg 1564621 ctattgacgg agtagctaaa ggcggattac tggcaatccc acttttgttt ttgtcaacca 1564681 gttcttttat agctggcaaa aagatcggta aagataaagg ccgaatgaaa ttttgcgttg 1564741 ttacaggaat gattctgtta accctttcgt ttattgcctt gtggtggaac cacagttttt 1564801 attttttatt tgtcttttta agctttggcg ggattgggat tggaatggct cttcctgctt 1564861 tagatgcatt gataaccgaa gggattgaaa gtgaacaatg cggaaccatt tcctcctttt 1564921 acaatagcat gcgctttata ggagtagctc tcggtccacc tgtttttgct gcattaatgt 1564981 ctaatgcaaa ctggattatt ttcatactct cggcgttttg cagcatcgtt tctttatttt 1565041 tagtgctctt tactgtagat gctaaaaaaa gtgaagaaga aaaaaactta gggacggtct 1565101 agccagccgt ctttttttgc gctttcttgc acagtttaca actgtaccta tacagcatgc 1565161 ggaggttatt gtttccttat aaatcctaca gttgctataa ttacatgaaa gagtgtttct 1565221 gcggatgctg aaaattggtc ataatacata ctaattaaga aatgaacgaa ggaggttcca 1565281 tatgtcatat gttaatgaac tcaaatcaaa gcacggcggt ttaaccgcac acattgtaaa 1565341 aacagaaaaa ttcaaaaccg tctcgcttat ttttaagatg cttgcgccgc tgacaaagga 1565401 tcaagtcacc aaaagagcgc ttctcccgca tgtgcttctt cgcggaacga aaagccatcc 1565461 gaaaaccgca ggattgcgtt catacttgga tgagctgtac ggcacgtcag tatcggctga 1565521 tcttacgaaa aaaggagagc ggcatgtcat tacgttcagg cttgaaatcc cgaatgaaaa 1565581 atatttaaaa gaccaaacgc cgcttctcga gaaagggctc cagcttctcg cagaactcgt 1565641 cttttcacct gctttggagg gagacgcttt tcagtcacaa tatgtggctc aagaaaaacg 1565701 gacgcttaag caaagaatcc aagccgtcta tgatgataaa atgcgttatt cgaatttaag 1565761 gctgatacag gaaatgtgca aaaatgatcc ttacgcgctt catgtcaatg gtgaaatcga 1565821 cgatgtcgat gacattacgg cagagcaatt atacgaaaca taccaaagcg ctatccaaaa 1565881 agaccagctt gatctatatg ttgttggcga cgtggacagt aaccaggtac aatcggcaat 1565941 tgataagtat ttcaaaacag aagagcgcac tcttggcatg attgaaaaca atcacgctga 1566001 tgaaaaagtt cagccaaaag aagtaattga tgaagaggat gtcaagcaag gaaaactgaa 1566061 tatcggctac cgcaccagca tcacttatac agatcaggat tatcctgctt tacaagtgtt 1566121 taacggattg ttcggcggat tctctcattc taaacttttc attaatgttc gggaaaaagc 1566181 cagtcttgct tactacgcgg cttcgcgtat agaaagtttt aaaggcttgt taatggtgat 1566241 gtcaggcatt gaagtgaaaa attttgaaca ggcggtttcg attattgctg agcaattcca 1566301 ggcaatgaaa aatggcgatt tcagtgagca ggatatagca cagacaaagg ccgttattcg 1566361 aaatcaagtg ctggaaacga ttgatacagc atacggttta tctgagtttt tatatcagca 1566421 ggccgctgct caagtcgaga ttcctatcga agactttctt gccaatattg agaatgtcac 1566481 aaaagaggat atcattaaag ccggcgaaaa gattcagctt gatacgactt atttcttaaa 1566541 agggacggag ggtgcatctt gatcaaacca atcgaatatg aacagcttca ggagacgctg 1566601 tatcatgaaa aaatgtccaa cggccttgat gtttacgttt tgccgaaaaa aggcttcaac 1566661 aagacatatg cggtctttac aacaaagtac ggctcgatag ataaccggtt tgtcccttta 1566721 ggtaaaaacg agatggttca cgtgccggac gggattgctc actttcttga gcacaagctg 1566781 tttgagaaag cggacggaga cgtttttcaa gatttcagca aacagggggc ttctgccaat 1566841 gcgtttacgt catttacaag aacggcttac cttttctcaa gcacatcaaa tgttgaacgc 1566901 aatttagaga cgcttatcga tttcgtacag gacccatatt ttactgaaaa aacggttgaa 1566961 aaggaaaaag ggattatcgg gcaggagatt aatatgtacg acgataaccc tgattggagg 1567021 ctttacttcg gggtcattga aaacatgtac aaagagcatc ctgtcagaat tgacatagcg 1567081 ggaacagtgg aaagcatttc acatattaca aaagaccttc tttatgaatg ctatgaaacg 1567141 ttttatcacc cgagtaacat gctccttttc attgtcggcc ctgtagatcc tgaagcgatt 1567201 atttctcagg taagagaaaa ccaggggaaa aagccgtata ctgatcagcc ggagatcaaa 1567261 cgagaagaag tgaaagagca agaagcggtt ttccgaaaag aaaaagagat caaaatgaac 1567321 gtgcagggac cgaaatgcct tgttgggctg aaatccaaaa atccgtttaa attaggcaaa 1567381 gagctcttaa agcatgaact ttcaatgaac ttattgcttg aagctctttt tggcaaaagc 1567441 tctgcccagt atgaatcact ttatgaaaaa ggatatattg acgaaacgtt cagctttgat 1567501 tttactgctg aatatgggtt cggttttgcg gcgatcggcg gagatacgcc tgagcctgat 1567561 caattggctg aagacatttc aagcatgctt ttgcgcgccg gtgaactgat tactgctgaa 1567621 aagattgaac ttgccagaaa gaaaaagatc ggcacattct taaaagcgct gaattcccct 1567681 gaatacatcg ccaatcaatt tacccgttat gcgttcttgg atatgagcct gtttgatgtt 1567741 gtaacggtac tcgagcagat taccctcgag gatgtccaga acgtaataca agaggaaatc 1567801 gctgcagaca gactgactgt ctgcaaggtt gttcctaaat cataaacaaa acatccctcc 1567861 agtgtgaggg gtgtttttct gcggaaagaa ggaaagagga tgaacaaaac agcactaatc 1567921 accggagcaa gcggcggcat tggcaaaagc atcagcgaaa cccttgcagc tagaggatac 1567981 aatctgctgc tgcattacaa tacaaatcaa aacgcggcag cggagcttgc tgaaaaacta 1568041 agtcagatgt ttggcgtaaa tgcggagata ttacaagctg acctgtccgc gcaagatgga 1568101 gcagataagc tgacaagttc aattgttcag ccgattgatg cgattgtttt aaacagcgga 1568161 cgaagccatt ttgggctgat tacggatgta gataacgcaa cggtccagga aatggttcag 1568221 cttcatgtgg cgagtccgta tatgctgacg agaaaccttc tgccaggcat gattcggaat 1568281 aaatcgggag cgattgtggc tgtcagctcg atttggggag agactggagc atcctgtgaa 1568341 gtgttgtaca gcatggcaaa aggagctcag cattcatttg taaaaggatt ggctaaggag 1568401 ctggcgccaa gcggaatcag agtaaacgcc gtagcgccgg gtgcagttga tacaaatatg 1568461 atgaatcaat ttaccccggc tgaaaaagaa gagatcgctg atgagattcc gatcggccgg 1568521 ctggcccggc cgcaagaaat tgcggatgca acagcttttc tcctgtctga aaaagcgtca 1568581 tatatcaccg gccaaattct gtcggtgaat ggcggctggc actgctgatc cgaaaatatt 1568641 cggtgtatag tttcttttgc gaaggacaca ataatcttgt aacttcacat gaaatggagg 1568701 aaacaagcat gtcagtatta gaaaactggg atagctggaa aaacttcctt ggcgaccgtc 1568761 tgaactatgc gcaagataaa ggtatgagcc aggatacgat tacagatctt gcgacagaaa 1568821 tcggcagcta cttggctaat gaagtggaat ctaagaacga gcaggaaaaa gtgctggcag 1568881 atctttggag tgtagcatca aaagatgaac agcacgccat tgccaatatg atggttaagc 1568941 ttgttgaaaa taacagcact cactaggaag agaggggatt tttcctctct tttttatgtt 1569001 ttcctcatca cagcaacatt cttctttcta attagagaaa aatgctttat gataaaggaa 1569061 ggtaaaattt tgccacaatg aagggggtat atcatttggc aaagctcgaa tggtattttg 1569121 aatatgaaat tcaagtgaac cgccccggac tgctcgggga tatttcatct cttcttggga 1569181 tgctttctat caacatcgta acgataaacg gcgtcgatct ttccagaagg ggaatgctcc 1569241 tcaggtgccg ccatatagat caaattaaac gattagaatc aatcttaaaa acgatggaaa 1569301 caattaaagt aacgaagctt agagaaccga ggcttcgcga ccgtcttgcc gtacgccacg 1569361 gccgttatat tcaacgggat gccgatgaca agaaaacgtt ccgctttgaa cgggacgagc 1569421 ttggcttatt agtcgatttt atggccgaat tgttcaaaaa agaaggccat aaattaatcg 1569481 gaatcagagg tatgccgcgt gtcgggaaaa cggaatcgat tgtagcctct agtgtgtgcg 1569541 agcaaaaggt ggctgtttgt gtcatcaacc ttgctgaagc agacgataag aagccagctg 1569601 attgccgatg aatacagcac tgaaaatgtc tttatcgttg acggaattgt gtcaacacga 1569661 agagggtcag aacgccatct ccagctggtc cgagaaatca tgcggctgcc tgcaacaaaa 1569721 gtggtggagc atccggacat attcgttcaa aatacagagt atacactaga tgactttgat 1569781 tatattattg aactgagaaa tgaccctgat gaggttatta catatgaaca tgccgaggaa 1569841 ccccaaatgt ttgatcaatc cgggttttca agctttgatt tttaaaattg gaaggtgttt 1569901 gttgtgactg aactaggaat ccggctcaaa gaagccagag aggaaaaagc aatgtcattg 1569961 gatgatctcc aagcggcaac aaagattcaa aaaaggtatt taaccgcctt ggaggaagga 1570021 aactatgaca ttattccggg gaagttttat gttcgggcat tcatcaagca atatgcagaa 1570081 gccgttgggc ttgatgcgga tcagctgttt gaggagcata aaaaagatat ccctaatacg 1570141 tatcatgatg atgtgtctga aaagatctcc ggcatgaatc ttcaaaagga aatgccaaag 1570201 ccagcatcta aggcgctgga gctgctgcca acaatacttg ttattctcgg cgtgattgtc 1570261 gtgattgcca ttgtgtacgc gatcattcaa tttgccaatc acaaaaacag tgatgatcac 1570321 aatgcggcat cagaaaaagc aattacgcaa agtgagagca agtacgaaat ccctaaagat 1570381 tcaacgctga aagagaatca aaataacagc tctgaaaaag agacagacac taaaaaagaa 1570441 acgaaagaaa acgaagataa gaaaaaagaa aatgacagtg agaagctgga gattaaagct 1570501 gctggcactg aaggatcgtt aacgacttat gaagtgtccg gcgctgataa aatcgagctg 1570561 gaactgaagg catcagacag ctcctggatt agagtgcgcg atgaaaacag cagctcttta 1570621 aaagaaggaa cgctgaaaaa agacgaaacc tataaaaaag acataactga tcagaaacaa 1570681 gttgatatcc gcaccggata tgcacctaat ctgaaaataa aaatcaacgg taaggttctt 1570741 tcatatgaac ttgatccgaa aaaagtgatg gcacaaacca taaagattgt aaataaaaag 1570801 gaagaaaagt catcttaatt accagatgac ttttcttcac gtccgagtat gaaattggag 1570861 gggctttatg tttaacttac caaataaaat cacactagct agaatcgcat taatcccaat 1570921 cttcatgatt atcatgctgg cgccgtttga ctggggcagg ctcgaagttg gagacgaatc 1570981 catcccggtc gcacatttgg cgggggccat tctatttatt attgcatcta caacagactg 1571041 ggtggacggg tattatgccc gaaaattaaa tctcgtaaca aacttcggga aatttcttga 1571101 tccgcttgcg gacaaactgc tcgtatccgc agcgttaatt atccttgttc aatttgatct 1571161 cgctccagct tggatggtca ttgtgattat cagcagggag tttgccgtga caggtttaag 1571221 gcttgtctta gccggaacag gagaagtcgt agctgctaac atgcttggta aaatcaaaac 1571281 ctgggcacag attattgcgg tatctgcatt gcttcttcat aatcttccat ttgaacttgt 1571341 gtcattcccg tttgcagact tggcgctgtg ggtagccgtc ttctttactg tcgtctcagg 1571401 ctgggaatat ttctctaaaa attgggaagc gttaaaaaca tctaactaag aaagaaggac 1571461 ttcgtcatgg aatttccaaa aaaagcagaa ataattgcag tcggttcaga gttgctgctt 1571521 ggtcaaatcg ccaatacaaa tgctcaattt atcagcaaac agctcgctga aatcggggtc 1571581 aacgtatttt atcatacagc ggtcggagat aacccggagc ggctgaagca ggtcatccgc 1571641 attgctgaag aacgctctga cttcattatt ttttcaggag ggcttggacc cacaaaagat 1571701 gatctgacga aagaaacgat tgcaaatacg ctgggacgtc cgcttgtgtt aaatgatgag 1571761 gcattccaat ccattgagga ctatttcaaa cgaacaaaac gcacgatgtc acctaataac 1571821 cgaaaacagg cgcttgtgat cgaaggctct gacgtgctgg cgaatcactt tggaatggcc 1571881 ccgggaatgc tcacagagca tgaatcgcgc tattatatgc ttcttcctgg accgccgagc 1571941 gaattgcgtc caatgtttga aaacgaggca aagcctcttc tgctgaaaaa gatgggttca 1572001 aatgaaaaaa ttgtgtcaac tgttcttcgc tttttcggta tcggtgaatc tcagcttgaa 1572061 gccgatttgg aagatattat tgatgcacaa accaatccga caattgcgcc tttggcggct 1572121 gatggagagg tgacgctgcg tctgacagcc aaacacgccg atgaaaagga aacagagcgt 1572181 ctgttaaaag aaacagaggc cgttatctta gagcgtgtcg gtgaattttt ctatggttac 1572241 gatgatactt ctcttgtaaa agagctatct atagcatgta aggaaaaagg cataacaatt 1572301 tctgcggcag aaagctttac cggagggctg ttttctgaat ggctgacgga tcatagcggt 1572361 gcctcaaaat tatttgccgg gggcgttgtt tgctatacaa acgacgtgaa gcagaatgtg 1572421 cttggtgtca agaaggaaac attagatcgt tttggggcgg tcagcaagga gtgcgcatcc 1572481 gaactggcta agggtgttca aaaactcact ggcagcgata tcggcattag ctttactggt 1572541 gtagcaggac ctgatgctca agaagggcat gagcctgggc atgtgtttat cggcatttcc 1572601 gcaaatggta aagaagaggt tcacgagttt cactttgcgg gctccagaac ggggatcaga 1572661 aaacgcggcg ctaaatacgg ctgccattta atcttaaagc ttttagagca aaaataatat 1572721 tttcagcaca ttatcctcct aagaaaacat gatttctctg atacattatg atattttgat 1572781 aggaatcacg ccaagaaaaa atccgaatat gcgttcgctt ttttcttggc aaatcccttc 1572841 aaacagggta tagtatatgt agtggtaaca taaaggagga aaaaatagaa tgagtgatcg 1572901 tcaggcagcc ttagatatgg ctcttaaaca aatagaaaaa cagttcggca aaggttccat 1572961 tatgaaactg ggagaaaaga cagatacaag aatttctact gtaccaagcg gctccctcgc 1573021 tcttgataca gcactgggaa ttggcggata tcctcgcgga cggattattg aagtatacgg 1573081 tcctgaaagc tcaggtaaaa caactgtggc gcttcatgcg attgctgaag ttcagcagca 1573141 gggcggacaa gccgcgttta tcgatgcgga gcatgcgtta gatccggtat acgcgcaaaa 1573201 gctcggtgtt aacatcgaag agcttttact gtctcagcct gacacaggcg agcaggcgct 1573261 tgaaattgcg gaagcattgg ttcgaagcgg ggcagttgac attgtcgttg tcgactctgt 1573321 agccgctctc gttccgaaag cggaaattga aggcgacatg ggagattcgc atgtcggttt 1573381 acaagcacgc ttaatgtctc aagcgcttcg taagctttca ggggccatta acaaatcgaa 1573441 gacaatcgcg attttcatta accaaattcg tgaaaaagtc ggtgttatgt tcgggaaccc 1573501 ggaaacaaca cctggcggcc gtgcgttgaa attctattct tccgtgcgtc ttgaagtgcg 1573561 ccgtgctgaa cagctgaaac aaggcaacga cgtaatgggg aacaaaacga aaatcaaagt 1573621 cgtgaaaaac aaggtggctc cgccgttccg tacagccgag gttgacatta tgtacggaga 1573681 aggcatttca aaagaaggcg aaatcattga tctaggaact gaacttgata tcgtgcaaaa 1573741 aagcggttca tggtactctt atgaagaaga gcgtcttggc caaggccgtg aaaatgcaaa 1573801 acaattcctg aaagaaaata aagatatcat gctgatgatc caggagcaaa ttcgcgaaca 1573861 ttacggcttg gataataacg gagtagtgca gcagcaagct gaagagacac aagaagaact 1573921 cgaatttgaa gaataaaaat aaaataagtt tcaaatgata caaaaggctg agtgaaaaac 1573981 tcagcttttt tgtattttgc aaaaaaatga taaaaatatt gctttttttg acaacttttt 1574041 tagggcttta ttcgtctaac aaaacgtgtg caaaatggaa tttattttgg gaggaaaaaa 1574101 tgaatgacaa gcccaacccg cagaagaact gcgaaacgca gacggagaaa actaaataaa 1574161 agaggaaaac tgttgtttgg tcttttagca gtgatggttt gcattacgat ttggaatgct 1574221 cttcatcgaa atagtgaaga aaacgaacca tctcaagaaa ctgcagcggt ttcaaatacc 1574281 gatcagaaaa aagaggtcaa aaagaaaact gccaaaaaat cagaggaaca aatcaaaaca 1574341 gtggatcgaa accaaaaaat cagcaattat ttaaaagaga tcggtttcag cggaacagcc 1574401 atgattgtca gaaatggaga aatcgtaaca aataaaggtt ttggctatgc tgaccgtaaa 1574461 cactacattc aaaataatcc attgacatct ttttatgtcg gttcatcaca aaaagcgctg 1574521 attgcaactg ctattttgca gcttgaggaa aaggggaaac ttcagacaag tgatccggta 1574581 agcacgtatt tacctcattt tcccaacgga caaacgatta ctttgaagaa tctgcttaca 1574641 catacatcgg ggataaacgg acatattgaa ggaaacggcg ccattactcc ggacgattta 1574701 ataaaagata tagaacttca gggaatcaaa cgtcagccgg gcgtatggga ctacaaggat 1574761 tccaactatt ctgttcttgc ttatattatt gctgaagtaa gcggtgagcc ctatgaacag 1574821 tacataaaga atcatatttt taaacctgcg ggaatgacgc atgcaggctt ttacaaaaca 1574881 tatgaaaaag aaccttatcc tgccgtcggg tataagatgg agggcagcaa aacagttaca 1574941 ccgtatatac ctgatttatc ccagctgtat ggagcgggtg atatttatat gagcgctata 1575001 gatatgtaca aatttgacca agcgctgata gacggaaaac tgtattcgca aaaaagctat 1575061 gaaaagatgt ttacgccagg gagcagctcc acatacggca tgggatttta tgttgctccc 1575121 ggaagctatt caaaccatgg tgttatgccg ggcttcaata tcttgaacag ctttagcaaa 1575181 tctgggcaaa ccattgttat tttgttctca aacattcaaa ataatgctaa attgggccaa 1575241 gtgaacaata aaatatacca gcttctaaat caagaatgat tggcgatctt cttttggatg 1575301 aattgcattc ggcacgtgaa aagaagactg gcctgcaaac gttaagatgg caagcttgac 1575361 aagtatttcc gacacattta caatgaagtt gtaacatttg tttttttaac atgattgtta 1575421 aaccatttaa acttgacaag ggcgatgaac acactcattc cctgtgaagg ttctgtatgt 1575481 tgagaaaact agacaatgta catgccgaca ctttttaagc aacaaccaag ttcatagcaa 1575541 gaggaggtga aagtatgacc ccaattatga tggttctcat ctccattttg ctgattctac 1575601 tcggtttagt tgttggctac tttgttcgta aaaccattgc cgaagcgaaa attgcgggcg 1575661 cacgcggtgc agccgagcaa attcttgaag atgcgaagcg tgatgctgaa gcactgaaaa 1575721 aagaagctct gcttgaagca aaggatgaaa tccacaaact tcgaatagat gctgaacagg 1575781 aagttcgtga aagacgaaat gagcttcaaa aacaagaaaa ccgtttactc caaaaggagg 1575841 aaaaccttga tcgcaaacat gagggaattg ataaacggga agcgatgttg gagaagaaag 1575901 atcattctct gaatgaacga caacaacata ttgaagagat ggaaagcaaa gtggatgaga 1575961 tgattcgtat gcagcagtct gagttggaac gaatttcgag tctgactcgt gacgaagcga 1576021 aacaaatcat tcttgagcgg gttgaaaacg agctttcaca tgacatcgcc atcatgacaa 1576081 aagaaactga aaaccgtgcg aaagaagagg cggataagaa agcgaaaaac attctttcac 1576141 tcgccttaca gcgctgcgca gcggaccacg ttgccgaaac aacggtatca gttgtcaatc 1576201 ttccaaatga tgagatgaaa ggacgtatca tcggacggga agggcgtaac attcgtacgc 1576261 ttgaaacgct gacaggaatt gacctgatta ttgatgatac gcctgaagct gtcattcttt 1576321 ccggatttga tccgatcaga cgtgagacag ccagaattgc tcttgataaa ctcgttcagg 1576381 atggccgtat tcatccggca cggattgaag aaatggttga aaaatctcgc cgcgaggtcg 1576441 atgactatat tcgtgagatg ggtgagcaaa cgacatttga ggttggcgtt catggcctcc 1576501 acccagatct catcaagatc ctcggccgct taaagttccg tacaagctac ggtcaaaatg 1576561 tgcttaagca ttccatggaa gtcgcattct tggccggtct aatggcatcg gagcttggtg 1576621 aagacgcaaa gcttgctaaa cgtgcgggtc ttcttcacga catcgggaaa gcaattgacc 1576681 atgaagtaga aggaagccac gttgagatcg gggtagagct tgcgaccaaa tataaagagc 1576741 acccagtcgt gattaacagt attgcatcac accacgggga cgaggagccg acttccatta 1576801 ttgctgtact ggtagctgca gcagatgcgc tttccgctgc aagacctggc gcaagaagtg 1576861 agacgctcga gaattatatt cgaagacttg aaaaacttga agaaatttct gagtcctacg 1576921 aaggtgttga aaaatcattt gccattcagg ctggacgcga agtgcgaatt atggtgaagc 1576981 cggattcaat taatgatctt gaggctcatc gactggcgcg agatatccgc aagcgaattg 1577041 aggacgagct cgattatcca ggtcatatta aggtgacagt aatcagagag actcgagccg 1577101 tagagtatgc aaaataaagt gatgcgctaa gcatcacttt atttttttga cggcaaggaa 1577161 ttttcaagaa gaaaggattt acaaaatgag aattttattt atcggagatg ttgtcggttc 1577221 accgggccgt gacatggtca aagaatatgt accaaagcta aaaacaaaat ataagcctca 1577281 ctttaccatt attaatggtg aaaacgccgc acatggaaaa ggcctgacgg aaaaaattta 1577341 tcacagctta atccagtccg gcgcagatgc aatcacaatg gggaaccaca catgggacaa 1577401 aaaagaaata tttgatttta tagatgacgt tccgaacttg gttcgcccgg caaactttcc 1577461 tgaaggaaca ccggggaaag ggatcacata tgtgaaagca aacggcaaag aactagcagt 1577521 cattaatttg cagggacgta cgtttttgcc gccgcttgat gacccgtttt taaaagcgga 1577581 tgaattgatc gcagaagctg cgaaaagaac accgtacatt tttattgact ttcatgccga 1577641 agcgacaagt gaaaagctcg cacttggctg gtacacggat ggacgggcat cggctgtagt 1577701 aggaactcat acacacgtgc aaacagcgga taaccgcatt ttgccgaagg gaacggcata 1577761 tattactgat gtgggaatga ctggcccgta tgacggtata ctggggatgg acagagagac 1577821 gattattaag cgattcaaaa cgaaccttcc agtccggttt actgtcgctg aaggaaaaac 1577881 aacgctcagc ggagttgtca ttgacattga cgatcaaacg aaaaaagccg tgaaaattga 1577941 gcgtatttta atcaacgatg atcacatgtt ctttgaatag ttgaacatat ggttatttta 1578001 taaaaatatt aaaaagaaaa gcaggaatat agcaactcct tagtgaatat agtaaaaatg 1578061 gaaggtagcc cgctattttt gaaaagcatt gtggggatgg ctttttggat agcaacatct 1578121 aataatgatt gttctaatga acactcactt atccattgta aaactaaggg ggagcagaaa 1578181 tggaaatctt aaaagtttca gcaaaatcga gtccaaattc agtggcaggt gcgcttgcag 1578241 gcgtgttgag agagcgagga gccgccgaga ttcaagcgat cggagcgggt gcattaaacc 1578301 aggctgtaaa agctgtggcg attgccaggg gatttgtggc gccaagcggc gttgatttga 1578361 tttgtattcc ggcttttaca gatattcaaa tcgatgggga agaaagaaca gcgattaaat 1578421 taatcgtgga gcctcgctaa aaacaaataa agcattctca acctgtttgc gtaatgcaaa 1578481 caggttgttt ttcatttatt gtgatatttt ctcccgatag tatttttagc acataaatga 1578541 gcgaatatac aaaatcagaa atgagctaaa acgtttcaaa aaaaatttcc gcccattttt 1578601 caagacagat acttttgtcc ttctggaaaa gacagttctg tttacgctta ttccatatca 1578661 tggtacaatc cgaatataac aagaattttt caaggaggat tgtacatgca gagtggaaag 1578721 atgaaagctc taatgaaaaa ggacggggcg ttcggtgctg tgctgactga agttcccatt 1578781 cctgagattg ataaacatga agtcctcata aaagtgaaag ccgcttccat atgcggcacg 1578841 gatgtccaca tttataattg ggatcaatgg gcacgtcaga gaatcaaaac accctatgtt 1578901 ttcggccatg agttcagcgg catcgtagag ggcgtgggag agaatgtcag cagtgtaaaa 1578961 gtgggagagt atgtgtctgc ggaaacacac attgtctgtg gtgaatgtgt cccttgccta 1579021 acaggaaaat ctcatgtgtg taccaatact gctataatcg gagtggacac ggcaggctgt 1579081 tttgcggagt atgtaaaagt tccagctgat aacatttgga gaaatcccgc tgatatggac 1579141 ccgtcgattg cttccattca agagccttta ggaaatgcag ttcataccgt actcgagagc 1579201 cagcctgcag gaggaacgac tgcagtcatt ggatgcggac cgattggtct tatggctgtt 1579261 gcggttgcaa aagcagcagg agcttctcag gtgatagcga ttgataagaa tgaatacagg 1579321 ctgaggcttg caaaacaaat gggagcgact tgtactgttt ctattgaaaa agaagacccg 1579381 ctcaaaattg taagcgcttt aacgagtgga gaaggagcag atcttgtttg tgagatgtcg 1579441 ggccatccct cagcgattgc ccaaggtctt gcgatggctg cgaatggcgg aagatttcat 1579501 attctcagct tgccggaaca tccggtgaca attgatttga cgaataaagt ggtatttaaa 1579561 gggcttacca tccaaggaat cacaggaaga aaaatgtttt caacatggcg ccaggtgtct 1579621 cagttgatca gttcaaacat gatcgatctt gcacctgtta ttacccatca gtttccatta 1579681 gaggagtttg aaaaaggttt cgaactgatg agaagcgggc agtgcggaaa agtaatttta 1579741 attccataaa gggggataaa catgacgaag gaatttgagt ttttaaaagc agagcttaat 1579801 agtatgaaag aaaaccatac atggcaagac ataaaacagc ttgaatctat gcagggccca 1579861 tctgtcacag tgaatcacca aaaagtcatt cagctatctt ctaataatta cctcggattc 1579921 acttcacatc ctagactcat caacgccgca caggaggccg ttcagcagta tggagccggc 1579981 accggatcag tgagaacgat tgcgggtaca tttacaatgc atcaagagct tgagaaaaag 1580041 ctggcagcct ttaaaaaaac ggaggcggca cttgtattcc aatcaggctt cacaacaaac 1580101 caaggcgtac tttcaagtat tctatcaaaa gaggacattg tcatctcaga tgaattgaac 1580161 catgcctcta ttattgacgg aattcgactg acaaaggcgg ataaaaaggt gtatcagcac 1580221 gtcaatatga gtgatttaga gcgggtgctg agaaagtcaa tgaattatcg gatgcgtctg 1580281 attgtgacag acggcgtatt ttccatggat ggcaacatag ctcctctgcc tgatattgta 1580341 gagctcgctg agaaatatga cgcatttgtg atggtggatg acgcccatgc atccggagta 1580401 cttggcgaaa acggcagggg aacggtgaat cacttcggtc ttgacggcag agtgcatatt 1580461 caggtcggaa cattaagcaa ggcaatcgga gtgctcggcg gctacgctgc aggttcaaag 1580521 gtgctgatcg attatttgcg ccataaaggc cgtccatttt tattcagcac atctcatccg 1580581 ccggcagtca ctgcagcttg tatggaagcg attgatgtct tgcttgaaga gccggagcat 1580641 atggagcgct tgtgggagaa tactgcctat tttaaagcaa tgcttgtgaa aatgggtctg 1580701 actctcacga agagtgaaac gccgattctt cctattttaa taggtgatga aggtgtggca 1580761 aagcaatttt cagatcagct cctttctcgc ggtgtttttg cccaaagtat cgttttcccg 1580821 actgtagcaa agggaaaagc cagaattcgc acgattataa cagcagagca caccaaagat 1580881 gaactggatc aggcgcttga tgtcatcgaa aagacggcaa aggagctcca gctattgtaa 1580941 caagaggaag agtttactct tcctcttttg attccttatt gattattatt ctcaatgagt 1581001 gtacaatgat aggttgccag ttgtgcagag cttcaataac ctttatactg aagggtggaa 1581061 gtttggtttg aaaggagaaa atatgacatg aatgaaaaac aaaaattaga gagcggacaa 1581121 gttcatccat cggacaaaaa atccgagaag gattacagca agtactttga agctgtttac 1581181 attccgcctt ctttaaaaga cgcgaaaaaa cgaggcaagg aagccgttac ttatcataat 1581241 gactttaaaa tttctgaaca atttaaagga ttgggagacg gaagaaagtt ctatatccgt 1581301 acgtacggct gccaaatgaa tgaacacgat acagaggtta tggcagggat ctttatggcg 1581361 ctcggttacg aagcgacaaa ctctgttgac gatgccaatg tcattttgtt aaatacatgt 1581421 gcaatccgtg aaaatgctga aaacaaggtg tttggtgagc tcgggcactt aaaagcactg 1581481 aaaaaaaaca atcccgatct gattttaggc gtgtgcggct gtatgtccca agaggaatca 1581541 gtcgtgaacc gtattttgaa aaaacatccg tttgtcgata tgattttcgg aacgcataac 1581601 attcatcgcc tgccggagct tttgtcagaa gcataccttt caaaagaaat ggttgtagaa 1581661 gtttggtcta aggaagggga cgttattgaa aaccttccaa aagtccgaaa tggaaaaatt 1581721 aagggctggg tcaatatcat gtacggctgt gacaaattct gtacgtattg cattgtgcct 1581781 tacacacgcg gaaaagaaag aagccgccgc cctgaggata tcattcagga agtgagaagg 1581841 ctcgcaagtg aaggctataa ggaaattact ctgttaggcc aaaacgtaaa cgcgtatgga 1581901 aaagactttg aagatatgac gtacggactt ggtgatttga tggatgaact gagaaaaatc 1581961 gatatcccga gaatccgttt tacaacgagt catccgcgcg actttgacga ccgcctcatt 1582021 gaagtgctgg caaaaggcgg aaatctgctt gatcacattc atcttccggt tcaatcagga 1582081 agctcagaag ttctcaagct gatggcccgc aaatatgaca gagagcgtta catggagctg 1582141 gtgcgaaaaa ttaaagaagc aatgccaaac gcttctttga caacggacat tatcgtcgga 1582201 tttccaaatg aaacggacga acagtttgaa gaaacgcttt ctctataccg tgaagtggag 1582261 tttgacagcg cctatacgtt catttactct ccgcgtgaag gcactccggc tgctaagatg 1582321 aaagataatg taccgatgcg tgtgaaaaaa gaacgcctgc agcgtctaaa cgcactggtg 1582381 aatgaaattt ctgctaaaaa aatgaaggaa tacgaaggca aggttgtcga agtattagtt 1582441 gagggtgaaa gcaaaaataa ccctgatatt cttgctggct atactgaaaa aagcaagctt 1582501 gtcaatttca aagggccgaa ggaagccatc ggcaaaatcg tccgcgtgaa aatccagcaa 1582561 gcgaaaacat ggtcgcttga cggagaaatg gtaggagaag caatcgaggt gaaatgagat 1582621 gacgctctac tcaaaaaaag acattgtgca gcaggctcga aaccttgcaa aaatgatttc 1582681 tgaaacagaa gaggttgatt ttttcaaacg ggctgaagcg caaatcaatg agaatgacaa 1582741 agtgtccaca atcgttaatc agattaaagc cctgcaaaag caggctgtca atctgaagca 1582801 ttatgaaaag catgaagcgc tcaaacaagt agaagcaaaa attgacgcgc tgcaagaaga 1582861 gcttgaagag attcctgtta tccaggaatt cagagactcg caaatggaag taaatgacct 1582921 actgcagctc gttgcacaca ccatttccaa ccaagtcaca aatgaaatca tcacatcaac 1582981 cggaggcgac ctgctgaaag gggaaaccgg ttcaaaggtg aagcattcaa ataacagctg 1583041 ttctctctaa acacggtgcc tttacaggcc cgtgtttttt tatcatttgt gcggttaaaa 1583101 atgaactaaa taatctatgt accaaatgtt caattggttt ttctgtgctc agccgcgtat 1583161 aaactttatc gcacttataa gtaaagtttc taggcacccc tgcatacaat ggaacagaaa 1583221 ctttgtattt ttatatttta tttataaaaa tgcacactag acaaatgccc agcataagat 1583281 aacacgaaga agaacaagga ggcatgccgg aatgtctgaa tacagggaaa ttattacgaa 1583341 ggcagtagta gcgaaaggcc gaaaattcac ccaatgcacc aacaccatct cgcctgagaa 1583401 aaaaccgagc agcattttgg gtggttggat tattaaccac aagtatgacg ctgaaaaaat 1583461 tggaaaaacg gtagaaattg aagggtatta tgatataaac gtatggtact cttacgcgga 1583521 caacacaaag acagaggttg tcacagaacg ggtaaaatat gtagatgtca ttaaactcag 1583581 atacagagac aataattact tagatgatga gcatgaagtg attgccaaag tgcttcagca 1583641 gccaaactgc cttgaagtga ccatttcgcc gaatggaaat aaaatcgttg tgcaggcaga 1583701 aagagaattt ttggcggaag tggtagggga aacaaaggta gttgttgagg tcaatcctga 1583761 ctgggaagag gatgacgagg aagattggga agatgagctt gatgaagagc ttgaagacat 1583821 caacccggag tttttagtgg gagatcctga agaataaaaa agggactagg ggagacagta 1583881 cccccaagtc tcttttttat attgatatat cattctttta tcactttttg tttatgttat 1583941 aatgaaggtt ggaaaataga aacgttgata catagtgagg gattaaacaa tggccggtta 1584001 tacgcctatg atacagcaat atttaaaaat aaaggcagag caccaggatg cctttttatt 1584061 ttttcgcctg ggtgattttt atgaaatgtt ttttgaggac gccaaaaaag cgtcacaaga 1584121 gctggaaatt acgttaacga gcagagacgg cggtgcggct gaaaaaatac cgatgtgcgg 1584181 tgtgccgtat cattctgctt ccgcgtatat cgaacagctt attaaaaaag gatacaaagt 1584241 ggcgatctgt gaacagacgg aagatccgaa agccgcaaag ggcgttgtga aaagagaagt 1584301 agttcagctg attacgcccg gaactgtaat ggacggcaaa ggcatccatg agtcggaaaa 1584361 taattttatc gcatctgttt cagcctgctc gaacggatac ggacttgctc tgtctgattt 1584421 aacaacggga gaaaatttgg ctgttttgat tgaacggctt gaagacgtca tatcagaaat 1584481 ttattcagtc ggcgcacggg aaatcgtggt ttcaggaagc ttggatgccg atacagtggc 1584541 acagctgaga gagcggtgcg gtgcaacgat ttcaattgaa gacggagaaa cagacgaaca 1584601 cgtaacgatc attgagcact taaataatga agatataaca aaaacatttc tgcgcttata 1584661 tacgtatttg aaaagaaccc aaaagcgcag ccttgatcat cttcagcccg tgcaggtgta 1584721 tgagcttgag gaagcgatga aaattgactt gtactcaaag cgtaatctgg agctgaccga 1584781 aacgattcgt tcgaaaaata aaaaaggctc ccttttgtgg ctgctggatg aaacaaaaac 1584841 ggcaatggga ggccggctac ttaaacagtg gattgaccgg ccgcttatca gagtcaatca 1584901 aatcgaagag cgccaagaaa tggtggaaac attaatgtcc catttctttg aacgggaaga 1584961 tctgcgtgaa cgtttaaaag aagtatatga cttagaacgc cttgccggcc gcgttgcatt 1585021 cggaaatgtc aatgcccggg atttgattca gctgaaggaa tcgttaaagc aagtgcctgg 1585081 catcaaacag ctggttgctt cactggctca tgacaaggcc aaggaacgtg caaagcgcat 1585141 tgacccttgc ggggatgtac ttgaactgct ggaagaagcg ctgtacgaaa accctccttt 1585201 atcggtaaaa gaagggaacc tgattaaaga tggttataat caaaagcttg atgaatatcg 1585261 tgatgcaagc agaaacggaa aagactggat tgcccgcctg gaacagcagg agcgggaata 1585321 cacaggcatt cgctctttaa aggtcggctt taataaagtt ttcggttatt acattgaagt 1585381 gacaaaagca aacttgcatt tgcttgagga agggcgttat gagcggaagc agacgttaac 1585441 caatgcagag cgctacatta cacctgaatt aaaagaaaaa gaagcgctca ttttagaggc 1585501 ggaaaataac atctgtgagc tggagtacga gctgtttacc gagctgcgcg agaaagtgaa 1585561 gcagtatatt ccgcggctgc agcagcttgc aaaacagatg agcgagctgg acgcactgca 1585621 atgctttgcg acaatcagtg aaaatcgcca ctacacgaaa ccagagttct ctaaagatga 1585681 agtcgaagtg attgaaggca gacacccggt tgttgaaaaa gtcatggaca gccaggaata 1585741 tgtcccgaac aactgtatga tgggcgataa cagacaaatg cttctcatta caggtccaaa 1585801 catgtcaggg aaaagcacgt atatgagaca aatcgcgctc atttccatta tggcgcaaat 1585861 cggctgcttt gtacccgcga aaaaagcggt gctcccgatt ttcgatcaaa tttttacgcg 1585921 aatcggcgct gcagatgatt tgatttccgg acaaagtaca tttatggtag aaatgcttga 1585981 agcgaaaaat gcgattgtca atgcgacgaa aaacagcctc attctgtttg atgaaatcgg 1586041 gcggggaacg tccacttatg acggcatggc gctggcacag gcgattattg aatatgttca 1586101 cgatcatatc ggcgccaaga cgctgttcag cacacactat cacgagctga ccgttcttga 1586161 ggacaagctg ccccagctga aaaacgttca tgttcgcgct gaagaatata acggaacggt 1586221 tgtctttctt catcaaatta aagaaggtgc ggctgataaa agctatggta tccatgtagc 1586281 tcagcttgcc gaactgccgg gagatctgat tgcgcgcgct caagatattt taaaagagct 1586341 tgagcattca ggaaacaaac cggaagtgcc ggtgcagaaa cctcaggtga aagaagagcc 1586401 ggcacagctg tccttttttg acgaagcgga aaagccggct gaaacaccaa agctttcaaa 1586461 aaaagaaaag caagtgatcg atgctttcaa atcacttaat atactggata tgacaccgct 1586521 tgaagcgatg aatgaaatgt acaagctgca aaagaaatta cattaaaacg gggtgatgaa 1586581 tgtggcaaaa gtcatccaac tgtcagatga gctttcaaat aaaatagcgg cgggcgaggt 1586641 tgtggaacgg cccgcctcag tcgtcaaaga attggtggaa aatgcgatcg acgctgacag 1586701 cacagtcatt gaaatcgata ttgaggaagc aggccttgca tccattcggg tcttggataa 1586761 cggcgaagga atggagaatg aagattgcaa gcgagctttc cggcgccacg caacgagtaa 1586821 aataaaagat gaaaatgatt tattcagggt gagaacgctc ggtttcaggg gagaagccct 1586881 gccgagtatc gcgtcagtct ctcatctgga gattacaaca agcactggtg aaggagctgg 1586941 gacgaagctc gtcctccaag gaggaaacat catttccgaa tcgcgttcct caagcaggaa 1587001 gggaactgaa attgtcgttt ccaacctgtt ttttaacaca ccggcccgtt tgaaatatat 1587061 gaaaaccgtt catacagagc ttggaaacat tacagatgtg gttaaccgta ttgctctggc 1587121 gcatccagag gtatcgatcc gcctgcgcca tcatgggaaa aacctgcttc aaacgaacgg 1587181 aaacggagat gtgcgccatg tactggcagc gatttacggc acggctgtcg ccaaaaaaat 1587241 gcttccgctg catgtgagct ccttggattt tgaagtaaag ggatatatcg ccctcccaga 1587301 gattacacgg gcgtcgagaa actatatgtc gtctgtggtc aatggccgtt acattaaaaa 1587361 tttcccgctc gtcaaagcgg ttcatgaagg ctatcatacg cttctgccga tcggacgcca 1587421 tccgattact tttatagaaa ttacgatgga cccgatttta gtcgatgtca acgtgcatcc 1587481 atcgaagctt gaggtccggc tcagcaagga aacagagctt catgacttaa tacgtgacgg 1587541 aattaaagat gtgtttaaac agcagcagct gattcctagt gcccaggtcc cgaaaaaatc 1587601 agcacctgcc atcaaaaatg agcagcagtt tataaccttt gatgaaaagc ctccggaaaa 1587661 aaaagttccg gaaaaatcga ctgcgccatc ttattcaccg atgaagctca gctcagtcgt 1587721 aaaagagccg gttgatgcgg aggaaaaatt gccccctctc caatttgatg ctcctcctat 1587781 cgttgatcag gaacaaaccc ttgaggtgtc cgatgtttca gcagaacagc ctgaaacatt 1587841 tgagcaggaa tgccatgagg aacagccgca gccagcgtct gatcgggttc caattatgta 1587901 cccgattggc cagatgcacg ggacttatat attggcacaa aacgaaaacg gcctatatat 1587961 tatcgaccag cacgccgccc aagaacgtat taaatatgag tacttccgtg aaaaggtggg 1588021 ggaggttgag cctgaggtgc aggagatgat tgtaccgctg acgttccact actccacaaa 1588081 tgaggctttg attattgaac agcacaaaca agagctcgaa agcgtcggtg tctttttaga 1588141 gtcattcggc tctaacagtt acatcgtccg ctgccaccca gcctggtttc caaagggaga 1588201 agaagcagag cttatagaag aaatcattca gcaggtgctc gactccaaaa atatagatat 1588261 taaaaaactt cgcgaggaag cggcgattat gatgagctgc aaaggctcca tcaaagcaaa 1588321 tcgccacctc agaaacgacg aaatcaaagc gcttctggac gacctccgaa gcacatcaga 1588381 cccatttaca tgcccgcacg gccgcccgat catcattcac cactcgacat atgagatgga 1588441 aaagatgttc aaacgcgtga tgtagcgggg gtggtaggca ttgatccatt ctctgaatgg 1588501 atcaatgctt tttttgtact ccttcgagtg tcagattata agaaacggtt gtaaacgtgt 1588561 gagcagtgtt aacgcattat acttcatggt tcctccgtat aacaaaattt ccatttacag 1588621 gcaattggga ttaatgtata ttttgggtga gggggtggaa acatatggca tgtggtccga 1588681 agatcattat ctttttggat gaacttgatg atccaaatgt gagaatcatt ttagaatgca 1588741 gaatttaaat tacaacattg tgttttgctc cctgttcgtg tgaacaggga gattttttcg 1588801 tttatataac tggtgatgtc caaatatagg gtgttatgaa ttttccatat ctgccatcgg 1588861 ctttaagctg cttctctatt aggctggtta tcaaaagcaa gttcaatgat agccatgaaa 1588921 gctgatatca caacaagcaa gacatctgga atataaatag actgcataaa gtaatctgca 1588981 aaacagatcg ttataagatt gctgataaaa tacagtataa aagcaaaaag tgcagtcttt 1589041 ttcaatgaaa gtgattttgc caaaatgata gagataatct ttgtgagtgg gtctatgatt 1589101 aaacctacag caaagcaggc taaaataaat aaagctaatg tttgattgga agcgtatgtg 1589161 atgccaagta tggagaataa gcctttcatc ccgaagaaaa agccgccgaa gatgactgca 1589221 agcgcgatgg ccgcgataaa agtaatagat acaattccga ttaattttga tctcaggtta 1589281 aaatctttag agtgctcgtt ctgttctttt tggttcatgt atgacactcc cttcacctgc 1589341 ttactcatac aaacagcacc cttgaatcag cccaaaatat ctataagtct gttttctgac 1589401 gaaaatagta tagcatattt taacaaaacc aaaaaaggcc ctttccactg gggaagggcc 1589461 tttttcatca tgttaactcc tgagattcgc cgaagctttc tctttttttg gccaaataaa 1589521 atagctggct gtaatgagaa agtcaatgcc tataatgaca gtccacagtt taagaatgcc 1589581 gctcaacgcc tcggttcggg aagagtcatt gataaaatag atcatccctg ccaatagtcc 1589641 cgcaccaatt aagtaggcca gcacatgtct tagccagcct ttcgcaccgt gcttggcatg 1589701 gtccattcca aaacgtttca gcggttttgt tccttttttt gtcacataat attgaaactt 1589761 ttcatctgcc cattgaatca tttgtttccc ataagcgatc gatataccga tgtaaacagc 1589821 tgcaatccca tgggctgcgg tcgctgaggc tccgcggtaa aggtccacac cagttgccgc 1589881 taacaagatc aaatcgataa ctggagttaa ggcaaggaat agcagtccta atgtatgtcg 1589941 tttgaatacg tagcgtacag caagccccaa aacaatgaca acccaaaacg caatttcaca 1590001 gaaaacaatc atccatgcga taccgttcaa tccattcccc tcttttcaat acagttgtat 1590061 tatttaaata atatgttacc atctttgttt ttgtaacaca actgtattat aaaaattgcc 1590121 ccgcctttga acgaaagctc aaaggcgcta cgctgtatta ttttgatgaa agtggctgtc 1590181 agctgtgctg gatatcaatt gtatatactg cacgatctgt tacgaccttc aatccttcgt 1590241 tttcttggtg aatatgaagc tcacctaata aaggaatctc ataggcattt tgcggaagcg 1590301 gtacgtttcc gtcctcagtg aatgttgttc cttcgccttc taaaacaagc tcttctttcg 1590361 caacataatc atcaggatga ttcgtactgc gtatagccac tttttgaagg tggagaacaa 1590421 tctgatccaa gtctgatatc tcttcatcat gggtcaattc accttttcta atatcaagcg 1590481 tctggccgac ttttgattcc agccattgag aaagctgtgt attcgtgtgt gccatcaata 1590541 ttcctccttt tgatctacac gatactattc ccaattgctg catcttttac acgggaaaga 1590601 gccgccccac tctttatgta tgaaacagtt cgctgttgag tgccttgata tagcgtacgg 1590661 cagaacgctg gaccgattcg tcggcatttt ctttgacaac tttagagaaa gcattgtaaa 1590721 gccggttgaa ttgaagcggt tttactttgg ctgctatttc ttcaactttg gaggcgggaa 1590781 ggggaatgag atttgggtag ctgtacataa agctgaccca gtttcgatcc gccgcaaccg 1590841 taatgatatc tccggtcaat agacagcctt tcccttcatt gcccttgctc caatgcaaaa 1590901 cagcaccgcc tttaaaatgt ccgcccagtc ggtaaaggtc cagtcccggc ttcatattga 1590961 gcgtttcccc tgaccagaag tgaatgtgat tgcttggcct tgtcacccat tctttatcat 1591021 cctcatggat atagatcggc gcctgaaacg cttcagccca ctcaacctga gtagagtaat 1591081 aatgtggatg agacaaggcg atggcttgaa taccgcctaa ttcgttgatt tggtcaattg 1591141 tcttttggtc aagatatgtc atgcaatccc acagcacatt gaagccctta tgctgaataa 1591201 gatgggctgt ttgtccaatc gcaaactctg gttcagtttt gatgctgtaa agatgctctt 1591261 cttccttttt aaggatgttt tgaaggtttc ctttctcacg catgtcttca agggttgtcc 1591321 aagtttgtcc atcgggatga atatactgtc tttcatcctc gcaaatcaga cacgagttgg 1591381 gcggatctac agtctgtgca tgttgcacac cgcatgtatt gcagatataa tatggcactt 1591441 tcttcacttc cttcatctat tttccattat tttaccttat gattatgaat attcaaacga 1591501 aaaaaccggc agttctgctg agagagaatt gccggctttt gatgatgttt attggccggg 1591561 aacggaattt tctgcgttga cagcgcccgc tccgtagata ttcggatctt catctttcca 1591621 tttgtccgtg ccgtttttca aaagctcttt tacttcatca ggggtaagat ccgggttttg 1591681 ctgaagaatt aaagctgcga ttcctgcgca aatcggtgtt gccatcgagg ttcctgacat 1591741 tgtaaagtac tgagacccta cacggcttga cttttggagc ttatcaatat aagaattcgg 1591801 agagcgaagg gaaataatat taacacccgg cgctaaaata tcgggctttt ctttcccgta 1591861 tactgtcggg ccgcggcttg agaaggaagc gacagtatca tcatcgctgc ttgcagtatt 1591921 gttatcgtca agcgcaccta ctgtaatcac cttttcgctc acgcccgggc ttgcaatggt 1591981 ctgcgaatca gggcctgagt ttccggcagc gacacagacg acaatccctg cgctccacgc 1592041 ttcctcaacc gctctgacta acggatcttc ctgttcatga tcatatctaa gggcatcgcc 1592101 cccgagcgac atgctcataa tatcaatcgg ttcatcgggg ttgtcctcat tgtattgaat 1592161 acaccactca acaccctcta taatatctgc taacgttcct gaaccctgct tgtttaatac 1592221 ctttacgccg atgagattgg cttccggtgc aggtccgcgg tattgaccgg aagaggatgc 1592281 accgctgctt gcgacatcac ctgcacagtg tgtgccatga ccattatcat cgtacggctc 1592341 tgttttttga ttgaccatgt ccgcgaatcc gataattctt ccttctagat caggatgcgg 1592401 gtagattcct gtatcgacaa cagcgacagt aacacctttt cctgtcaggg tttgcccgtt 1592461 tctgacgact tccttcgcat ggcttgcttc ggttgccgtg tctaaaagcg ctttgacttc 1592521 gcggtttaaa tacactttac ggatattgct gcattcagag agaagggaat gtaatgctga 1592581 aggagtaacc tcggcgctgc agcagttgat tttgttgaag cggcttttta gcttgctgcg 1592641 tttttctttt tgcagcacct ctccagccat ttgaaagccg gtctcgtgac agccttcctc 1592701 aaattcgata atgactgaca ttttttttct gttttgcaat ttggtttcga aaaatttatg 1592761 caagaagcaa ggagtccatt tgaagggctt gtaaagttgc aatacggttt cccgtaacgg 1592821 ccaatctagc ttgtgagcat ttgctctcac catttgtacc atagagtacc caaacatgta 1592881 ttttcctcct attataaggt tctctgtata ctctatgaac agatgatagg tttggtaagt 1592941 ttgtttgtcc tctgtaagag acagacaaga gtttgttttt ctgaatcttt cgcattagat 1593001 acgatagatt cagaagctga ggaaatcatt ggggattgaa aaagaacgtt tgttcgtatt 1593061 ataatgtgat catatcaaac tgggaagggg agagcaaccg tatgaatttc tacttgcacc 1593121 gatctttgga aagccaaatg ccaatcagca ttatatatga agaaagacgg aacgattagt 1593181 aaaagaacga ttattgtgag acagaaaagc aaaacgaaaa tcaaagcatt ttgtttttcg 1593241 aaacaacaga tcagaacatt tttattggac tctatcctct cctgtgattt tgtgagaaca 1593301 aataagcaaa atctctattc tgcaggccgg taacagctgt ccgtctcagc aaccgggcag 1593361 cctgttacta aaaccctcct taaacctata tacatttatt tgccaagtga ggttgttcct 1593421 accttttttg tctttcctct caaccttttt tcactcttat ttgaaatgaa ccgctaataa 1593481 ccgtgacaat caattgattt tttgaaaccg ggaacttttt cactgatgat attgtgtata 1593541 caatggtaag ataaaaccta ttggctaaac ctcatataat gaaccgcgcc attcttatga 1593601 aaggagttaa acatgagaag atttttacta aatgtcatat tagtcttagc cattgtcttg 1593661 ttcttgagat atgttcatta ctcattggaa ccagaaccat caaatcagcc agatacatat 1593721 tcaaatttca gcagcttggc agagaatgag agcccagccg attacgatat ttcatataat 1593781 gagaaaaaag gaagcaaagt cttaattatg tctccgcatg gcggaagaat tgaaggcgga 1593841 gtaagtgagc ttgtgcgtta tttcaataat gaatactcta catacctatt tgaagggttg 1593901 aagtcccatg ataaccaaac actgcacatt acaagcacca actttgatga gccattggca 1593961 aaaaagaaaa tcaaggagca tcaatatgtg gtggcttttc acggatataa aggagagaac 1594021 aagaataccc ttgtaggggg aacagaccga aagcgggcga aaatgattgt gagagccctt 1594081 gagcggagag ggttttccgc tgagttagcg tcgtctaaaa gcggtcttgc tggattgaat 1594141 gccgaaaaca ttaataacca aggggaaacg gggctaagta tccagctgga aatcagccgt 1594201 gagcagagag aagcattttt tgatgatttt tattataaaa atagaaaata cacaaagaac 1594261 agtgaatttt atgcttatgt cagtgcgatc aaaggtgtcc tggaaaaaga gtattcgtaa 1594321 caagcagatc agaagacaaa ataagagaag atcagtagac tgaaatagga taaaaaagga 1594381 ggcaaaacaa tggcagatca tcatttttat ttaaaagcga actggccggg taaccgtaat 1594441 gatgtcggta cgatcgaaag cggaaacctg atcacatcga tttccattcc taaagaaatg 1594501 gatggcccgg gagaagggac caacccagat gaaatgcttc tcggggcggc agcgacctgt 1594561 tacattatta cacttgcagc gatgatggag agaagcgggc tggaaaaaga agacttacag 1594621 atggagtcag aaggcattgt caacgttaca aaaggagtct ttacatacaa aaagatcatt 1594681 caccgtccct ctgtcgtgct taaacatgat gcttcacaag acgacgtcgc attggcgcac 1594741 aaactttgta aaaaagcgga gtcgtcatgc atgatttcgc gtgcaattca aggaaatgtc 1594801 gagctgcagc ttgaagcctc tgtgaaactg ggtggagaat aaagaaaaca gacggtcact 1594861 cacaggccgt ctgtttttta tcttcagcgt gggctttcga ttgatttagc acgaccacgc 1594921 ctgcaatgac aagcgtgaga ccgaatacac cttttaaact gatggtttcg ccaaaaagca 1594981 aaaacccgac aattgctgta agcgcggtac caacgcccga ccatgttgca tacgcgcttg 1595041 ataagtcaat tgtttttaaa gaaaagctta gaaacgtaaa agcagaaaga aatccgacta 1595101 tgactccggc aatgggccag gcttgtgtaa atccttctga aagcttcaac atcgtgctcc 1595161 caaacacttc agatacaatg gcgagagcca aataaagcaa tcctctcatc ttcatcactc 1595221 ctttacggcc aattaagtaa cacgacccct gatagtaata aaagaatccc gataagccct 1595281 ttggcattca gatcttcctt gaaccatttt actccgatca ctgtcgtcag caccgtgcct 1595341 gccccgctcc aagtcgcata ggagaggctc aggggaatat ggtttaaagt cagggacagc 1595401 atataaaagg cgagggaata gccaataacg accaaagcac ttggcttcca ctttttgaag 1595461 ccatcagata ctttcagcat ggctgctcct atcgattccg aacatatggc aatcgtgagg 1595521 aatatatatc ctatcaacat catgaattct cctcactata tttttagatt agaaaaaaaa 1595581 cttcagctag aaaaatatta gtgtatgcct atgtatgagt caagagattc attttcacac 1595641 acttaaaaag accccttttt aaggggtctt ttgcgtttaa taataaaaag ggaacggggc 1595701 atacggataa taggggtatc cgccatacaa ataaggatta aataaagcgc ttcctataag 1595761 cccgcctgca aggccgccga taaacggtcc tccaaaaaat ccgaatggcc ggccaaaccc 1595821 ataaccaaat ccgggtcttc caaacccgta accgaacccg aacggtcttc caaacccaaa 1595881 tggtctcccg aatccgaacg gccttccaaa tattcttgta tcttcagggc tgaaatgctc 1595941 taactcgttc atgttttctt tcctcctgta ataaagtgta gatgatgcag tgtattcacc 1596001 ctgcccggat ttgattgggc gaatcgagga aaaggaggat gtgaacacat tgggcctgta 1596061 tcagtctgac tggtcaaaag caccgcccca cgcacatgct tatcatgtca aaacaacgag 1596121 agaacagggc cattatcatc tcatcgaagg gtttactcag ccggcaaacg gatcaaatac 1596181 cgatcagcat acacattact atacagggat cacttcattt gaaaacggcc attttcatcg 1596241 gtattacgga atctcaggac cggcgattcc cttagcagat ggcacacatt atcatgaaat 1596301 cgaagaaacg acgtatctgg cctataacga gccgattgag atccagtacg gaggggttgt 1596361 gtacgatccc ggagatgaca gaagaaaaac gcatcgtcat accctgaaag gaaagacaag 1596421 ggaaattgtc ggcaatgagc cgctcggctg gtagaaggat gtttaccgat gcaaaaaaag 1596481 ggcaaaatgg ataggtggtt gtccatgttg aatgctataa tggggggaga tttataaaag 1596541 agagtgatac atattgaata atacgaagca gcccgttgtc attttagtcg gaccgacggc 1596601 agtggggaaa accaatttaa gtattcagct agccaaatcc ttaaacgcgg aaattatcag 1596661 cggagattcg atgcagattt ataaagggat ggatattgga acagctaaaa ttaccgaaca 1596721 ggagatggag ggagtgcccc atcatctgat tgacatttta gatccccaag actctttctc 1596781 tactgccgat tatcaaagct tagtaagaaa taaaatcagc gagattgcaa atagaggaaa 1596841 gcttccgatg attgtcggcg gtacagggct ttatatacaa tctgtgcttt acgattatac 1596901 atttacggaa gaggcaaatg atcccgtgtt tcgagagagc atgcaaatgg ctgctgagcg 1596961 ggaaggcgct gactttcttc atgccaaact tgctgcagca gatcccgagg cagcagctgc 1597021 gattcatccg aataatacaa gaagagtcat tcgcgcactg gaaattttac atacgtccgg 1597081 aaaaacgatg tcccagcatt tgaaggaaca aaaacgagaa cttctgtaca atgcagtgtt 1597141 aattggcctg acaatggata gagacacgct ttacgaaaga attaatcagc gggtcgattt 1597201 gatgatgcag tcaggccttc ttccggaagt gaaacgctta tacgacaaga acgtgagaga 1597261 ctgtcaatca atacaggcga taggctataa agagctgtat gcatattttg acggttttgt 1597321 gacactttcc gatgctgtcg aacagctaaa gcagaactcg aggcggtatg cgaaacgcca 1597381 gctgacgtgg tttcgcaaca aaatgcaggt cacatggttc gatatgacac cgcctgttga 1597441 tatggagctg aaaaaaaagg aaattttcac acatatagca ggaaaactcg aactttaatc 1597501 gaaactgtat gatatagaga atcaaggagg acgaaacatg aaaccgatta atattcagga 1597561 tcagtttttg aatcaaatcc ggaaagaaaa tacgtatgtc actgtttttt tgctgaacgg 1597621 ctttcagttg cggggccagg tgaaaggctt tgataacttt accgtattgt tggaatcgga 1597681 aggtaagcag cagcttatat ataaacatgc gatctcaacg tttgcgccgc aaaaaaacgt 1597741 ccagcttgaa ctcgaataga tcaaaaaatg ccatgtcaag acatgaggaa aggctgtcgg 1597801 gggttcccgg cggccatttt taacatgaat ccacttttgc tccaagcttt ttgtgtaagc 1597861 tgaccatgcc aaggcacggt ctttttttat gagaacaaca tacggaagta aaaatggtat 1597921 attatgtata aaatgaattt gggagtgatc gatcttgttt gaaagtgaag cagaactgag 1597981 acgaatcagg attgcacttg tatggatagc tgtcttttta ctgttcgggg cgtgcgggaa 1598041 tcaagatacc attattgaaa cagacaacgg caattcagac tatgaaacgc ctcagcccac 1598101 ctcgtttcca cttgaacata accattttgg cgttatggag gacggctata tcaaaattta 1598161 tgagtataat gagtcccgca atgaggtaaa gctgaagaaa gaatacgcgg atgatgagct 1598221 tgaataaaat tcacaagcat tcgaatttac aaagcggatg ccagccgcta aactaaatac 1598281 agacacagat caaacagagg gtgaaaacat gaagcataaa gtgatcgtga atcattggga 1598341 agaaatttgc gaagatgatt cttgctatga atacggaaca agtatcattg tgaacggaaa 1598401 agaattaatc agagaagcgt caattatcac tgctttgaag gcggttttag aagagatcgg 1598461 cgcggatgtt gaaatagaag aaacagtaga gagcgaaaaa tgctgtgata gcttaagaaa 1598521 aaaaaatcta gactactaag cagttttttt tcatgttatg atatacatcg gctaaaaacg 1598581 acaccccgag taggacgaga gatgattctc gttctgctct cttttttggg ccctaatgag 1598641 tctgcccgtt tgcctgattt gatcaaaata tgaatttttc ataaaaacga atctatatat 1598701 tgtgtttttg ctagagggta gtatactata tatagtgtta gtgatgagag attcatattt 1598761 tttgataggt cgtgataaaa cgtggtacaa atcatatttg attcgaaaac agggaatgtt 1598821 cagcggtttg tgaataaaac aggctttcag cagatacgca aggtggacga aatggaccac 1598881 gtggacactc cgtttgtttt ggtcacctac acgacaaact tcggccaggt accggcatca 1598941 acacaatcat ttctcgaaaa atacgcccat ctcttattgg gagtcgctgc gagcggcaac 1599001 aaagtatggg gcgataactt tgcaaaaagc gccgatacca tttcaagaca atatcaggtg 1599061 ccgatcttgc acaaatttga actcagcggc acatctaaag acgttgaatt gtttactcag 1599121 gaggtagaaa gagttgtcac aaaatcaagt gccaaaatgg atccagttaa ataacgaaat 1599181 catgatccaa aaagatggga aattccagtt tgataaggat aaagaagctg tacatagcta 1599241 ttttgtagat tatatcaatc aaaacacagt cttctttcac aatttaaaag agaagctgga 1599301 ttatttggtt gaaaaccaat actacgaaga ggaattctta agcctttatt cttttgaaga 1599361 cattaaagaa gtgtttaaga cagcttacgc taagaagttt cgttttcctt ccttcatgag 1599421 tgcgtttaaa ttctataatg actatgcttt gaaaacgaat gacaagaaaa aaatcctcga 1599481 gcgttatgag gaccggatct caattgttgc gctgttcttc gctaacggcg acactgagaa 1599541 agcaaaagaa tatgtaaacc tgatgatcaa tcaagaatat cagccgagca caccgacatt 1599601 tttgaatgcc ggcagaaaac gccgcggtga acttgtgagc tgcttcttgc tcgaagttaa 1599661 tgattcttta aatgacattt caagagcaat cgatatctcc atgcagcttt ctaagcttgg 1599721 tggcggggtt tctcttaacc tgtccaagct tcgcgcgaaa ggtgaagcca ttaaagatgt 1599781 tgagaatgcg acaaaaggcg ttgtaggcgt catgaagctt cttgataacg cgttccgtta 1599841 cgctgaccaa atgggacaaa gacaaggctc cggcgcggcg tatttaaaca ttttccaccg 1599901 cgatatcaat gattttcttg atacgaaaaa gatttctgcg gatgaagatg tgcgtgtcaa 1599961 aacgctttcg atcggtgttg tcattccgga taagttcgtt gagcttgcac gcgaggacaa 1600021 agcggcttat gtattctacc cgcacacgat ttataaagag tacggccagc acatggatga 1600081 gatggacatg aacgaaatgt acgacaagtt tgtcgacaac cctcgggtga aaaaggaaaa 1600141 aatcaacccg cggaaactgc ttgaaaaatt ggcgatgctt cgttctgaat caggctatcc 1600201 atacatcatg ttccaagata acgtcaataa agtgcatgcg aataaccata tttccaaggt 1600261 caaattttct aacctttgct ctgaagtgct gcaggcatct caagtttctt catacacaga 1600321 ctatgatgaa gaagatgaaa tcggtctgga tatttcctgc aacctgggtt cgcttaacat 1600381 tctcaatgtc atggagcata aatcaatcga aaagacagtc aagcttgcga cagactcttt 1600441 aacacacgtg tctgaaacaa cagacatccg taatgcgcct gctgtaagac gggcaaacaa 1600501 agcgatgaaa tcaatcggcc tcggtgctat gaaccttcac ggctaccttg cgcaaaacgg 1600561 cattgcgtat gaaagtccgg aagcgcgtga ctttgcaaac acgttcttta tgatggtgaa 1600621 tttctactcc atccagcgtt ctgcggaaat cgcaaaagag aagggcgaaa cgtttgatca 1600681 atatgaagga tcaacctatg cgacaggtga atacttcgac aaatacgttt caactgattt 1600741 ctcaccgaaa tacgaaaaaa tcgctaatct gtttgaaggt atgcatatcc cgacgacaga 1600801 ggactggaaa aagctaaaag catttgtcgc tgaacacggt atgtatcaca gctacagatt 1600861 atgcattgcg ccgacaggct ctatctcata cgttcaatca agcacggcgt ctgttatgcc 1600921 gattatggaa cggattgaag aacgaacata cggcaactca aaaacgtact acccaatgcc 1600981 tgggcttgca tctaataact ggttcttcta taaagaagcc tacgatatgg acatgttcaa 1601041 ggttgtggat atgatcgcca ctatccagca gcacattgat cagggaatca gctttacatt 1601101 gttcttaaaa gacacaatga cgacccgaga tttaaaccga atcgatctgt atgcacatca 1601161 tagaggaatt aaaaccattt actatgcaag aacgaaagat actgggcaag acagctgcct 1601221 ttcttgtgtt gtttgattaa aggagagttt atagtgacaa aaatttatga cgcagcaaac 1601281 tggtcaaagc atgaagacga ttttacccaa atgttctata accaaaacgt gaaacagttc 1601341 tggcttccgg aagagattgc tttaaacggc gatctcctca catggaagta cctcggaaaa 1601401 aatgagcagg acacttatat gaaggtactg gccggactta cgcttcttga cacagagcag 1601461 gggaatacgg ggatgccgat cgtggctgaa cacgtagatg gccaccagcg gaaagcggtg 1601521 ctgaacttta tggcgatgat ggagaacgct gtccatgcga agtcgtactc taatattttc 1601581 atgacccttg caccgactga aacgatcaat gaagtatttg aatgggttaa acaaaataaa 1601641 tatttgcaga aaaaagcgca aatgattgtc gggctttaca aagccattca aaaagatgat 1601701 gaaatttcac tgttcaaagc catggttgct tccgtctatc tggaaagctt ccttttctac 1601761 agcggtttct attatccgtt atatttctac ggacaaggaa aactgatgca aagcggtgag 1601821 atcattaacc tgatccttcg tgacgaagcg attcacggcg tgtatgtcgg tctccttgct 1601881 caggaaattt ataataaaca gacagaagag aaaaaagcag agcttcgtga atttgcgatc 1601941 gacctcctga atcagttata tgaaaatgag cttgagtata cagaggactt gtacgatcaa 1602001 gtcgggctct cacatgatgt aaagaaattc atccgctata atgcgaataa agcgctgatg 1602061 aaccttggat ttgatccata cttcgaagag gaagacatta atccgatcgt tttaaacgga 1602121 ttaaacacaa aaacaaaatc gcatgacttc ttctctatga aggggaatgg ctataaaaaa 1602181 gcgacagttg agccgctcaa agatgatgac ttttattttg aagatgaaaa agagcagata 1602241 taatatctgc tcttttcggc ttgaaggttc aaatgaggag gacgcagtac ccatgggaaa 1602301 aatggacgaa atgattttag ttgccccgcg cgatgatgtg tttaaaaaag aaagcttaac 1602361 cttccagggc gtgtacagtg aagatagcag agtagcagaa atcatggctc agattgaagc 1602421 ggcctatcgt gaaatgagaa gaggggacgc agaagaagat ccgcgtttca agcagccgat 1602481 accttatgtc gtcattaagc gtgaagatga agtttttctt tacgagcggc tggctggcgg 1602541 cggtgaatca cgtctgcaca acaagctttc tctcggtttt ggcggccata tgaacgccat 1602601 cgaaggggca gcttcatttg ctgaagtctt aaagctgaac acagaccgtg agcttgagga 1602661 agaactgcaa ataaatgaag aagataaaca ggcgattgtc acactgggat tgatcaatga 1602721 tgatgaaaac agtgttggca aagtgcatat cggtattctt tctgcgcttc aattaaagcc 1602781 tggcgcacaa gtggaagtga aggagaaaga acaaattgcg ggtaaatgga tgaaagtttc 1602841 tgaattaaaa caggatgata tctacaaccg tctggaaaca tggtcacagt ttgttgttga 1602901 tattcttgaa taaaaaaacc cggtttctcg cgatgaggag ccgggttttt ttatgagacg 1602961 ctcgtccccg tctcggctat gattctagga tcacaatagc gtcaaagccg gcatttttcg 1603021 ctctggcagc gagggtgtct gcattgtctt tggatgaaaa tgcgccaatc tgcactttgt 1603081 ataatccgtc ctttaaaagg acaatcgagt caaaaccttt ggcttcggca ttacttgcga 1603141 gcgagtcggc attcgctttg actttaaatg cgccgatttg aaccttatat aaccctgagc 1603201 tggaagtctt tttaaggtta aaggcttgct ccagcccgtt tgcatgtcct ctcgctaagc 1603261 tttgaataaa actgctcgtt ttcagcttat ttgcatcgga aacggtatca atgaagccgt 1603321 tctcggtcaa gagggcaggc attgccgact cccttaggac gtggaagttc gctgtttttt 1603381 tgccgcgatc ggcaaagtcg acagcttgta tcacttcaga gtgaattgtc gattgataag 1603441 tcgtcgtcgg ggctcctaca tctggataaa tatagctttc aaaacctgtg cctcccccgg 1603501 aattaacgtg aatggacaaa aagaaatctg ctccccagtt atttgcggca tttgtccggt 1603561 cgtttaagct gacatattgg tcgcttgtcc ggctcagcag cagagaaacg ccttcatatt 1603621 cattagttaa tatcgtacgt aaggctaaag cgatttgcag ggttaacgtt ttctcctgaa 1603681 ggccattacc tgttgcgcct ggatcagacc cgccatggcc aggatcaata aaaattttaa 1603741 ccatttttca tcacctcatt acaggatatg aaaaaacacg gcttctgctt gtacgattat 1603801 cattcaactg aaaaatgagg aaataaccct ttcacatcca gaaattattt ctcgggaaag 1603861 cgcacaattc aacatgaagc gacaacagat acggtccgac atgaaatctg tgcatacgcc 1603921 atatgtttgt atgtactatg ggttcggtta acctgcactg attcctgctg gttttaagct 1603981 ttgcgttcat attaaatcaa gcatttaaaa cgtaaattga tgaggaaagc tcctttcatt 1604041 aaagacaccg ctttataaat cgaaaaaaag aaaaacactt caggtatctt agggcgggta 1604101 atacgtttcg tacaaaaatc agcccgttgt atgaaaaaga aataatgaga aagaagctca 1604161 ctataatact ctgacaaaat gattaaaaac aaaatctcat ggtttgtcca ccccatgtcc 1604221 gtgaatacaa taagaaataa agtatttctc gggaaagcgc aggattcctt attgttcccg 1604281 aaaaaagcaa ttgtttcgac acatgatagg cgtttgtcac aatcggcatc cgcttgaata 1604341 tcatatagag agaacagaga ggtgaagatg ttggagcgcg ctgtgactta taaaaacaac 1604401 ggacagatca acattattct gaacgggcaa aagcaggtgc tgacgaatgc tgaggcagag 1604461 gcggaatatc aggctgcatt gcaaaaaaac gaagcaaagc acggcatttt gaaggaaatc 1604521 gaaaaagaga tgagcgcatt agttgggatg gaggaaatga aacgcaacat caaggaaata 1604581 tacgcctgga tttttgtgaa ccaaaaacgc gcggagcaag gcttgaaggt tggaaagcaa 1604641 gcgctgcaca tgatgtttaa aggaaatccg ggaacgggaa aaacgacggt tgcacggctc 1604701 atcggcaagc tgttctttga aatgaatgtc ctgtcaaaag gccacttaat agaagcggag 1604761 cgggctgacc tggtcgggga gtatatcgga cacaccgccc aaaagacgag agatttaatc 1604821 aaaaagtcat taggtggcat tttgtttata gacgaagcct actcgctggc aagaggcggc 1604881 gaaaaggact ttgggaaaga agcgatcgac acacttgtaa agcatatgga agacaaacag 1604941 catgagttta ttttgatact cgccggatat tcacgggaaa tggatcattt tctctcgtta 1605001 aatcccggac tccaatcaag atttcccatc tccattgatt ttccggatta ctctgtgacc 1605061 cagctcatgg agattgcgaa acgaatgatc gatgaaaggg aataccagct cagtcaagaa 1605121 gcggaatgga aattgaaaga ttacttaatg acagtgaaaa gcacgacaag tcccattaaa 1605181 ttcagcaatg gacgttttgt cagaaatgtg atcgaaaaat cgatcagagc acaagccatg 1605241 aggcttttaa tgggagacca atacttaaaa agcgacttga tgaccatcaa aagccaagat 1605301 ctttccatta aagaagaagc atctggatct gcatagacct ctcagttttt gagaggtctg 1605361 ttttttgctc gtatttccgc ttttcaaagc aatcgatttg tggtatacac atgcagggtt 1605421 tggtatgata atactactgc ccaatatgca aaagaaagga acatccattt gaacgaacaa 1605481 gaaacgattc aggagaaagc cattttagtc ggatgtcagc tgccgcatat cacggatgag 1605541 cattttgaaa attctatgga agagctagca tctctgacga aaacagcaga cggaaaagta 1605601 ctgaccagcg tcacacaaaa acggaacagg gctgacgccg ctacatatat aggaaaaggg 1605661 aaggtagaag agctgaaggc actcgtggaa gagcttgaag ctgatctcct catctttaat 1605721 gatgaactgt cgccaagtca gctgaagtca ttggcaacag caattgaagt gaagatgatt 1605781 gaccgcacgc aattgatatt agatattttt gcaaagcggg cgagaacgag agaaggcaaa 1605841 cttcaaattg agctggctca gctgcaatat gcactgccgc gtctgacggg acaagggatc 1605901 aacctttccc ggcaaggcgg aggaattggg gcaagaggtc ccggggaaac gaaactggaa 1605961 accgaccgcc gccatatcag aaatcgcatt catgaaatca acacacagct ttccactgtc 1606021 attcgccata gaagccgata ccgtgaaaga agaaagaaaa acggtgtgct tcaaattgcg 1606081 cttgtcggct atacaaacgc agggaaatca acatggttca accgcctgac gagtgctgac 1606141 agctatgaag aagacctcct gtttgccacg ctggacccga tgaccagaaa aatggtcctg 1606201 ccaagcggct acagtgttct tctttcagat acagtaggat ttattcagga tcttccgacg 1606261 acattgattg ctgcattccg ctcaacgctt gaggaagtaa aagaagcgga tttaattctg 1606321 catttaattg attcttcaaa tgaggattat gcgggacatg aaaaaacagt gcttcggctg 1606381 cttgaggagc ttgaagcaga tgatatcccg atgctgacgg cttacaataa acgtgatcaa 1606441 aaactgcctg attttatacc gaccgccgga agggatcaca ttatggtcag tgcgaaattt 1606501 gaggacgacg ctgcagcctt taaagaagcg attcagcgct atttgcgcca agaactgtta 1606561 acgtcttttg aagcacatgt gccggcaagt gaagggaagc tcctttccag aatcaaatcg 1606621 gaaacgatgg tagaccgctt ctattttaat gaagaaaatg aacagtatga catatccggc 1606681 tatgtccaag aagagcaaag tatcatcggt gaattaaaga agtatatgta ggaaggaaat 1606741 ataaagacat gtttgacaca ttaacacacg gagaattatt gaagaaaacg gcaatggaag 1606801 tggaagcgga cattgccggc attcataaac aaatagaaga aatcagcgag cgaaatgagt 1606861 ggagagtgct tcaaagctat agaaaacaca aagtaagcga cactcatttc acgccgtcta 1606921 ctggatacgg ctatgatgat atcggaagag acacgcttga aagcatatat gcggatgtgt 1606981 ttggcggaga agcggggctt gtaaggccgc aaatcatttc aggcacacat gccatctcaa 1607041 ttgctttgtt cggtgtcctc agaccggggg acgagctcct ttatatcacg ggcaagccgt 1607101 atgatacgct agaggaaatt gtgggcgtca ggggtggaga aaacgctggt tcgttaaagg 1607161 attttcaaat cggctataat gcggttgatc tgacgaaaga cggaaagata gactatgatg 1607221 cagtcgccgc tgcgatcaat ccgaagacaa aagtaatcgg cattcagcgc tcaaaaggat 1607281 atgcgaatcg cccttctttc ttaattagtg aaataaaaga aatgatccgt tttgtaaaag 1607341 aaatcaatga aaatctgatc gtctttgtgg acaactgtta cggagaattt gtggaagagc 1607401 ttgagccttg ccatgtcgga gccgacctga tggcgggatc tctcattaaa aatcccggcg 1607461 gcggccttgc gaaaacaggc ggctacctcg tcggaaaagc gaaatggatt gaagcttgct 1607521 cataccgtat gacgtcaccc ggcatcggca gagaagcggg ggcatctctt tactcgctcc 1607581 aagaaatgta ccaaggcttc tttttggcgc ctcacgttgt gtctcaaagt ttaaagggag 1607641 cggtgtttac agcgagattc cttgaaaaac tcggcttcac ttcaaacccg aaatgggatg 1607701 cgaaaagaac ggatttaata caatccgttg agttttctga cagagaaaag atgattgctt 1607761 tttgccaggc tattcaattt gcatcgccaa tcaatgctca tgtgacgcct tatccagcct 1607821 acatgcctgg atacgaggat gatgtcatta tggcagcagg gacgtttatt caaggagcaa 1607881 gcatcgaatt atcagctgat ggccctatcc gcccgccgta tgtagcgtat gttcagggag 1607941 gattaaccta ttcgcatgtg aagaatgcca tatgcagtgc agtggattca ttgatgcaaa 1608001 agcaattaat ttaaattttt taaaaatttc tctggatttg atgttaagaa tccttacatc 1608061 gtattgacac ataatataac atcacctata atgaaactaa gttaagaaaa ggaggaaatt 1608121 gagatgagtg ataatattcg ccgctcaatg cctttatttc caataggaat tgtcatgcag 1608181 ttaactgagt tatcagcaag acaaattcga tattatgagg aaaatggact gatatttcca 1608241 gccagaagtg aaggaaatag acgattattt tcatttcatg atgtagataa actgttagaa 1608301 atcaagcacc tgatagaaca aggtgtaaac atggcaggaa ttaaacagat tctggcgaaa 1608361 gccgaagccg agccagaaca aaaacaaaac gagaagacga aaaaaccaat gaaacatgat 1608421 ctgtccgatg acgaactgag acagctcctg aaaaacgagc tcatgcaagc cggccgtttt 1608481 caaagaggga atacattccg tcaaggcgac atgtcccgct tctttcatta atccgttagc 1608541 aactgttttg ctatatacat ttacctttta agaggaggaa ttttaccaaa tggcaaagta 1608601 cactagagaa gatatcgaaa aattagtaaa agaagaaaac gtgaagtata tccgccttca 1608661 atttactgac attcttggaa caatcaagaa tgttgagatt cctgtaagcc agcttggaaa 1608721 agcgcttgat aataaagtca tgtttgacgg ttcttctatt gagggattcg ttcgtatcga 1608781 agagtcagac atgtacctgt atccagatct aaatacattt gttatcttcc catggacagc 1608841 tgaaaaaggt aaagtagcac gtttcatctg tgatatttac aatccggatg gcacaccttt 1608901 tgaaggtgac ccgcgaaaca acttaaaacg gattctgaaa gaaatggaag acctcggctt 1608961 cagtgatttt aaccttgggc ctgagcctga attcttctta ttcaaattgg acgaaaaagg 1609021 cgagccgacg cttgaactaa acgacaaagg cggatatttc gacttagctc caactgattt 1609081 aggagaaaac tgccgccgcg atatcgtact tgagcttgaa gagatgggct ttgaaatcga 1609141 agcgtctcac cacgaagtag cacctggtca gcacgaaatc gactttaaat atgctggagc 1609201 agtccgctct tgtgatgaca tccaaacatt taaactagtt gtcaaaacaa ttgcccgtaa 1609261 acacggcctg catgcgacat ttatgccaaa accattgttc ggtgtaaacg gttcaggtat 1609321 gcactgcaat ctatcactct tcaaaaatgg tgttaacgca ttctttgacg aaaacgcaga 1609381 tcttcagtta agtgaaacag cgaagcactt cattgcaggt atcgtgaagc acgcaacaag 1609441 ctttacagca gtaacaaacc cgacagtaaa ctcttacaaa cgtcttgttc ctggctatga 1609501 agcaccttgt tatgtagcat ggagcgcgca aaacagaagc ccgcttatcc gtatcccggc 1609561 ttctcgcggc atcagcacac gtgttgaagt acgcagtgta gacccagctg caaacccata 1609621 ccttgcactt agcgtattgc ttgctgcagg attagacgga atcaaaaaca aactggaagc 1609681 gccggctcca atcgaccgca acatctatgt gatgagcaaa gaagagcgca tggaaaacgg 1609741 aatcgttgac cttccagcaa cacttgcgga agcactagaa gaattcaaat caaacgaagt 1609801 catggtcaaa gcgctgggcg agcacctatt cgaacacttc atcgaagcaa aagaaatcga 1609861 atgggatatg ttccgcacgc aagtacatcc ttgggaacgc gaacagtata tgtctcagta 1609921 ttaatatctc aatcccttgg cactaaaagt gtcaggggat tttttatgtt aataggtaat 1609981 aaattatgga gcggcatagt gtttaacaca gccattaatc ctcagacagt caaatagcca 1610041 tttctactcc ggttgaaagc ttctctattt ttgcttctta tttatctttc ctgtattgat 1610101 atatgtatgt agggttggac ttataacata aactattctg gccattccgt tctttcaatt 1610161 catgaccggg cttgccatca gcataaatct aggctaacag tctccataca tcctgtgatc 1610221 acctttatca aactcttaaa tgcaacttac cactaaccaa ttctttattt cgcatagatc 1610281 atctttgtca tgtgtttaca caagaatctg ttttggactg agacactgaa tataacaaaa 1610341 cagtcaaaaa tcaatattta attcattctg tttaaacttt ctgaaaaaga tgttgaaaaa 1610401 gtcgaaagga ttttataata ttaagtcaag ttagtttgtt tgatcaacaa actaatgaaa 1610461 tgaactttca ttatccacaa gataagatct tactaatatg gatggaaggg ggataagagg 1610521 gtcgatttaa tggagctaaa caatataaga aacgaaagaa tgaggctttt atccttttcc 1610581 aggtatataa ggtatgacga aaaaagatga attttttgct tgctgatcac catatttttt 1610641 tgcactgttt tgaaagcgct tttataaaag tttactgacc gtaaattcga gaaattgtta 1610701 taccgtttca cactgttcca tattaaagga tcgaaaaggg gagaaatcat gctcagtgaa 1610761 aatgtaaaga agattagcat ggttgaaaaa gttggatatg cgtctggaga ttttgcttgt 1610821 aatttaattt atgcaacagt gtctacgtat cttttgttct tctatacaga tgtttttggt 1610881 ttatcggcag cagcagccgg tactatgttt ttagtggtta gaataatcga cgctctcgct 1610941 gatcctttta tcggaacaat agttgacaga acgaacagca gatttggacg ctttagaccg 1611001 tatcttttat tcggagcttt tccatttgtc atactggcaa tactctgttt tacaacacca 1611061 gacttttcgg atatggggaa attaatatat gcctatataa cctatgttgg cttgtcgctt 1611121 acatacacaa cgataaacgt tccatatggc gcgttaactt ctgcaatgac tagaaataat 1611181 caagaagttg ttagtataac ttctgttcgc atgttatttg cgaatcttgg gggacttgtc 1611241 gttgcatttt ttgttccctt actggctgct tatttaagcg atacttccgg caacgagtct 1611301 cttggctggc aactaaccat gggtattttg ggaatgatag gcgggtgcct tttaatcttt 1611361 tgttttaaaa gcacaaaaga gcgggtcact cttcaaaaat ccgaagagaa aattaaattt 1611421 acggatatat ttgagcagtt tcgtgttaat cgtccacttg ttgtattaag tattttcttt 1611481 attattattt ttggagtgaa ttccatcagt aattcggttg gcatttacta cgtaacgtat 1611541 aacttagaaa gagaggattt ggtgaagtgg tacggtttga taggaagttt acccgctttg 1611601 gtcattttac cgtttattcc aaggcttcat caatttttgg ggaaaaagaa attactaaac 1611661 tatgcattat tactgaatat tataggcctc ttagctttac tgtttgttcc gccaagtaat 1611721 gtttacctca tacttgtctg tcgattaatc gctgctgctg gaagtctcac tgccggggga 1611781 tatatgtggg cgcttattcc tgaaacaatt gaatatggag agtacaggac tgggaaaaga 1611841 atgggtgggc tcatttacgc tataatcgga tttttcttta agtttggtat ggccttagga 1611901 ggagttgttc cgggtctggt tcttgataag tttggatatg tagcaaatca ggcacaaacc 1611961 ccggcggcct taatggggat tttaattaca acaaccatta ttcccgtgtt cttgcttgtt 1612021 ctagctttaa ttgatattaa tttctataac ttagatgaga aaaaatataa aaacatggtt 1612081 cgagaattag agaatagaga caaagtttat ttggatcata ttgatgattt caaggcttaa 1612141 aaaagaaaat aaactgagga ggagtcccaa atgaagatta ccaatcccgt acttaaagga 1612201 ttcaatcccg atccaagtat ttgtagagca ggagaggatt attatatcgc tgtatctaca 1612261 tttgagtggt ttccgggagt ccagatacac cactcaaaag atttagtaaa ttggcactta 1612321 gttgcacatc cattacagag agtttcacaa ttagacatga aaggaaaccc aaattcaggt 1612381 ggagtttggg caccatgttt aagctatagt gatgggaagt tttggctgat ctatacggat 1612441 gttaaggtag tagatggcgc atggaaagat tgtcacaatt atttagttac ttgtgaaacg 1612501 attaatggtg attggagtga gccgattaaa ttaaatagct cggggtttga tgcttctttg 1612561 ttccatgata cggatggaaa aaagtattta ttaaatatgt tatgggatca ccgtattgat 1612621 cggcactcat ttggaggaat tgttatacag gaatattctg ataaagagca aaaattaatc 1612681 ggtaaaccaa aagttatatt tgaaggaact gatagaaaac tgacagaagc tccgcatctt 1612741 tatcatatcg ggaactatta ttatttatta actgcagaag gaggaacacg gtacgaacat 1612801 gctgctacaa ttgctcgttc tgcaaatatt gaggggccat atgaagttca tcccgataat 1612861 ccaattttaa cgtcatggca tgacccagga aatccattgc aaaaatgtgg tcatgcatcc 1612921 attgttcaaa cacatacaga tgagtggtat ttagctcatt taacgggacg tcctattcat 1612981 cctgacgatg attcaatttt tcagcagaga ggatactgtc ctttgggcag agaaacagct 1613041 attcaaaaac tttactggaa agatgaatgg ccctatgtag taggtggaaa agaaggaagc 1613101 ttggaggtag atgcaccttc tatacccgaa acaatatttg aagcaacgta cccggaagtt 1613161 gatgaatttg aggattcaac attaaatata aattttcaaa ctttaaggat tccattcacg 1613221 aatgaattag gttcattgac tcaagcgcca aatcatttac gattattcgg tcatgaatca 1613281 ttgacctcga catttactca ggcatttgta gccagacgct ggcaaagtct ccattttgaa 1613341 gccgaaactg ctgttgagtt ttatccggaa aattttcaac aagccgctgg gttggtgaat 1613401 tactacaata cagagaactg gacggctctt caagtcacgc atgatgaaga acttgggcgc 1613461 attcttgaat taacaatatg tgacaacttt tctttttcac agccattaaa taataaaatt 1613521 gttattcctc gtgaagtaaa gtatgtatat ttaagagtaa atattgaaaa ggacaaatat 1613581 tattatttct attcttttaa caaagaagat tggcacaaaa ttgacattgc actggaatcg 1613641 aaaaaattat cagatgatta tatccgtggg ggaggattct tcacaggggc ctttgtaggg 1613701 atgcaatgcc aagataccag tggtaatcat attccggccg actttagata ttttcgttat 1613761 aaagaaaaat aatttgcaca tgaaaaagga gatttctatt ttagaactcc tttttcatat 1613821 gagaaggtgc catgtcacta ttgcttcaga aatactccta gaataaaaaa actcatcttt 1613881 aaagatgagc tgtccattcc ataaaaaatt acattgtaat catgtccaga aaatgatcaa 1613941 tcacaatgga ggacattcct aatgccggtg cattctgtcc taaggaagat ggcaataatt 1614001 catagctatt gcctaattgg gaataaaccc ttgatgatac ttcacttctc attgaattta 1614061 aaaccatagg atgcgattca attatgctat ttcttaaaat tacggcttgt gggttgaaag 1614121 tatttagaat attggtaagg cctattccta aatagaatcc aaaattttgt aatgcattta 1614181 aggttccgat atcattcaga tgggcgaggt ttatgatatc ttgataggac agttttttct 1614241 ctttggtctg aagagatttt aataaagcct tctctgaagc atacaattcc cagcatcctc 1614301 ggtttccgca actgcattta ggaccattaa agtctattgt catatgtccc atttctccag 1614361 agaagccgct tactcctcta tataaatgat tgttgataat aacaccgatc cctattcctg 1614421 tgctgatact tacgtaaata atgttatcgt gattttttgc agctccaaat actttttctc 1614481 catatgcgcc agcatttgcc tcattttcaa taaaaacagg cacattgtac ttctcttgta 1614541 tcgaagattt taagtcaata tctctccagt tggagttcgg agtgaaaaca attttttgat 1614601 ctttatcaat gagtccaggc acgcaaatac ctataccaat aagcccgtac ggagattggg 1614661 gcatttgcgt aataaagtga tgaatcatat caatcaaaat gtctttcgtt atttctggag 1614721 aattggattc caaatggcgg tattgatcaa gaacgattgt tccttcaagg tctgttaaaa 1614781 tgccattaat ataatccaca ccaacatcta ttccaacgga gtatcctgcc tttttattaa 1614841 aaacaagcat gacaggtctt cttccgccac ttgattgtcc ttgacctatt tcaaatacca 1614901 tactttcttt cattaacgtg tttacctgtg atgagacagt tgatttattt aatccagtca 1614961 tttcagataa ttttgctctt gaaataggtg aatttttaag gatttctttt aataataact 1615021 tttgatttac ttttttgaca aaggtttgat cagcgatatc cacttcatcc actccatttg 1615081 tttaatcttt aaattaagta tcaacatagt acatagcgaa tcttcccttt attatatcta 1615141 atgtgttcat aaaaaactaa aaaaaatatt gaaaatactg acgaggttat ataagatgaa 1615201 aataagttag tttgtttaaa caacaaacta ataggtgatg tacttactat atgaaataaa 1615261 atgcatctgt atttgaatga atttattttt aagggggaaa tcacatggct caatctcatt 1615321 ccagttcaat caactatttt ggaagcgcaa acaaagtggt ttacgaaggg aaagattcga 1615381 ctaatccttt agcatttaaa tattataatc ctcaagaagt aatcggcgga aaaacgctga 1615441 aagagcattt gcgattttct attgcctatt ggcatacatt tactgctgat ggtacagacg 1615501 tttttggagc agctacgatg caaagaccat gggatcacta taaaggcatg gatctagcga 1615561 agatgagagt agaagcagca tttgagatgt ttgaaaaact agatgcacca ttctttgctt 1615621 ttcatgaccg ggatattgca ccagaaggca gtacgctaaa agagacaaac caaaatttag 1615681 atatgatcat gggcatgatt aaagattaca tgagaaatag cggcgttaag ctattatgga 1615741 atacagcaaa catgtttacg aatccccgtt tcgtccatgg tgccgcgact tcttgcaatg 1615801 cagatgtgtt tgcgtatgct gcagcacaag tgaaaaaagg gttagaaaca gcaaaagagc 1615861 ttggcgctga gaactatgta ttttggggcg gccgtgaagg atatgaaaca ttgttaaata 1615921 ccgatttaaa atttgagctt gataatttgg ctagatttat gcatatggca gtggattatg 1615981 cgaaggaaat cgggtacaca gggcagtttt tgattgagcc aaaaccaaaa gagccgacca 1616041 cccatcaata cgatacagat gcagcaacaa ccattgcctt tttgaagcaa tatggcttag 1616101 acaatcattt taaattaaat cttgaagcca atcatgccac attagccggg catacattcg 1616161 aacatgaatt acgcatggca agagtacatg gtctgcttgg ctctgttgac gcaaaccagg 1616221 gtcatcctct tttaggctgg gacacggatg aatttccgac ggatttatat tctacgacat 1616281 tagcaatgta cgaaatcctg caaaatggcg gccttggaag cggcggatta aactttgacg 1616341 cgaaggtcag aagatcttct ttcgagcctg atgatctaat atatgcccat attgcaggga 1616401 tggatgcatt tgcaagagga ttgaaagttg cccacaaatt aatcgaagat cgtgtgtttg 1616461 aagatgtgat tcaacatcgt taccgcagct ttactgaagg gattggtctt gaaattatag 1616521 aaggaagagc taatttccac acacttgagc aatatgcgct aaatcataaa tcaattaaaa 1616581 acgaatctgg aagacaggag aaattaaaag cgatattgaa ccaatacatt ttagaagtat 1616641 aacaggataa gctccagatc ctgctatcaa taccaagtca ctgaattacc cgtcatgatt 1616701 cctttcctat tgcttgttgt tatgacgggt aacttctata attaggattt atttagagtg 1616761 aatggttttt taaaagggca aggagtgaaa aaatgaagta tgtcattgga atagatcttg 1616821 gaacgagtgc tgttaaaacc attttagtta accaaaacgg caaggtttgt gcagaaacgt 1616881 ccaaaaggta tccgctcatc caagagaagg cgggatatag tgagcaaaat cctgaagact 1616941 gggttcagca aacaattgaa gcattggctg aattggtttc tatatccaat gttcaagcca 1617001 aggatattga cgggataagc tattcgggac aaatgcatgg attagtactg cttgaccaag 1617061 atcgtcaggt gttacgtaat gcaattcttt ggaatgatac cagaacaacg cctcaatgta 1617121 taaggatgac cgagaaattt ggcgatcatc ttcttgacat cacaaaaaac cgtgttttag 1617181 aagggtttac attacctaaa atgttatggg taaaggaaca tgaacctgaa ctttttaaaa 1617241 aaactgctgt gtttttgctt ccgaaagact acgtgcgatt ccgtatgacc ggtgtcattc 1617301 acaccgaata ctccgatgca gcaggaactt tacttttaca tattactcgc aaggagtgga 1617361 gcaatgatat ttgcaatcaa attggtattt ctgcagatat ttgtcctccg cttgttgaat 1617421 ctcatgattg tgtaggatcg ctgcttccgc acgttgccgc gaagaccggg ctattagaaa 1617481 aaacaaaagt gtacgctggg ggagcagata atgcttgcgg cgctattgga gcaggtatcc 1617541 tttcttccgg aaaaacatta tgcagtattg ggacgtcagg ggtcatactt tcctacgaag 1617601 aagaaaaaga aagagacttt aaagggaaag tccacttttt taatcatgga aaaaaggatt 1617661 ctttttatac gatgggcgtc acgctcgctg caggatacag cttggactgg tttaaaagaa 1617721 cgtttgcacc aaacgaatcg tttgagcaat tattgcaggg ggtggaagct attccgatag 1617781 gagccaatgg actgctatac actccttatt tggttggtga aagaacgccg catgctgatt 1617841 cttctattcg gggaagcttg atcggaatgg atggagccca taatagaaag cattttttga 1617901 gggcaataat ggaaggtatc acattctctt tacatgaatc aattgagcta ttccgcgaag 1617961 cgggaaaatc agttcatact gttgtttcta ttggtggggg agctaaaaat gatacgtggc 1618021 tgcaaatgca agctgatatt ttcaatacga gggtaattaa gttagaaaat gaacaagggc 1618081 cagctatggg ggctgcaatg ctggctgcct ttggaagcgg ttggtttgaa tcacttgaag 1618141 aatgtgcaga gcagttcatt cgtgaggctg ctgcatttta tccaaaggcg caaaatgttc 1618201 aaaaatataa aacactattt gatttgtata agaacattta cactcacaca aaggatctca 1618261 atacagcttt gaagagcttt cgaaaaaact aatgatgtta ttgtctggag atcaaccgaa 1618321 gaacaattaa tgatcaatca tcatcaaagg cctttgataa catggctgcc ttcttttgaa 1618381 aagatggtga gaataaggta tcgcaacctt taaacagtat tggagtatcc agcagacaaa 1618441 acgaacgagt ggaaccgtat tttgtcagcg aacacttcaa gaagtgggga agcttaggaa 1618501 tgccaatggg taagatgtat gaaaccgcgc taacgacggt agagggatct cttgatttat 1618561 gaagaaatag gaaggatgtt aacacacaaa taacccctca cattgacgtg aaggggtgtt 1618621 ttttattgtt actatacagc ggaaatttta caggctagtt gcatgatttt agcttgttaa 1618681 gcagaatgga actagactct ccatcatctc tttctcattc tttggaaact gcattctgct 1618741 aggtttgctg ctttttttaa caaacagtgt ttttctattt cacacagcca ttaaatcctc 1618801 tgttcgtcac ataaccgctc ttactccaaa ttgacagttt atctgatttt gcttcttgct 1618861 catctagtct gaattggtct atgtattttg tgttaggctc atatacatat gctactctgg 1618921 ccaatccctc tttcaataat gtctcttgaa cagatttgcc gtcaacataa acgtatgcta 1618981 acagtcttcc atacttatct ctgcgatcgc ctttatcaaa ttccagctgt agcttaccgc 1619041 tgttgaccaa ttctttattt cgtttcgacg catcctcacc gtatggttga acacaagaat 1619101 ttggtttctt cgtctcaggt gtatcaacga gcaagtagcg aactgtgtct ttctttccgt 1619161 tgtaaataac cttaatcgta tctccatcta ttgctctatc taatgtaaca ttgaccaatt 1619221 tcttctgatt ttttgaatga ggcgtgccag ccttttgttc tgtctgatta tattcattag 1619281 agtgagtatc ttgagagact tgctccgtcc cattagaatc tgaatggttt ttggctgcgt 1619341 gatttgatcc gcaagctgcc aaagtaatac ttaaaacgat tgcgatcata ctgatcaaaa 1619401 tcttcttcat attgattccc tctttatcat tttctctttt cgcgattaaa catcatcatt 1619461 ataacgatat ggacattttt tgtgaatgga aaacttcaag ggaacttata acactccaaa 1619521 ttgccaatag ttaacttcac aacgagatga tcaaaacatc accatcacat agcggaaata 1619581 aataatcctg aaaataatat tgactgaaaa tgcttttaga attatgataa tatgagaaat 1619641 gacaataatg tgacaaagac attactacaa cataacaact aatagcttag gtttattcta 1619701 ttggttaaaa atgtaaacgg ttacaaatcc agaggcgaaa atctaagata gagatgactt 1619761 tagttttgac tcaatatcca cactgaaaga gcttattaag tattcttaaa ggcaggggaa 1619821 atggatatga atgaacatcg aaatcgaagg ttgaaattaa taatgatttc agcaactttt 1619881 ggagggcttc tctttggata tgacaccgga gttataaatg gagctttacc ttttatggca 1619941 aggccagatc agcttgattt aacacctgtt acagaagggc ttgttacgag tattctttta 1620001 ttaggtgccg cgtttggagc gttgttatgc ggaagattgg ctgatcgata tggccgccgt 1620061 aaaatgatcc ttaatctttc ctttttattt ttcctggcat cactgggaac agcgttagca 1620121 cctaatgttt tcatcatggc ggtctttcgt tttttactgg ggctggctgt tggaggagcc 1620181 tcggcgatgg tgccggcctt tttagcagaa atggcaccgc atgaaaagag agggcgtatg 1620241 gtaacccaaa atgaactaat gattgttggc gggcaatttt tagcatatgt ttttaatgcg 1620301 atcctcggtg taacaatggc aaatacggga catgtttgga gatacatgct agtcatttgt 1620361 gctgtaccgg ctatcatgtt atttgccagt atgcttaagg taccagaaag cccccgatgg 1620421 ctaatctcca aaggcaaaaa cagtgaggcg ctgcgagttc ttaaacaaat tcgagaagat 1620481 aaacgtgcag aagctgaatg tagagaaatt caagaagcgg tagaaaaaga tacagcacta 1620541 gaaaaggcat cactcaagga cttttctaca ccatggctgc gccgtctttt atggattgga 1620601 atcggtgttg ccatcgtgaa tcaaattaca ggtgtgaact cgattatgta ttatggcaca 1620661 caaatcctta aagaatctgg ttttggtaca aaagcggctt taatcgctaa tattggaaat 1620721 gggctgatat cagttattgc agttatattt gggatttggc tggtcggaaa agtgagacgg 1620781 cgtccaatat tattgattgg tttggcaggg acgactacag cgctcctatt gattgcgatt 1620841 ttctcaattg tgcttgatgg atctatggca cttccttatg tagtgctttc tttgaccgtt 1620901 ttatttcttg cctttatgca agggtgtgta ggacctgtga cttggcttgt catagcggaa 1620961 atattccctc aaaggttaag aggacttggt tctgggataa gtgttttttt cctttggata 1621021 ttaaactttg tgatcggttt tgctttcccg atcttgctta gctctgtagg tttgtctttt 1621081 acattcttta tatttgtggc tttaggtgta ttggcaatcg gttttgtgta caaattcatg 1621141 ccggaaacaa aagggcgtac acttgaagaa ttagaagagc attttcgttc tcgacacgat 1621201 cataatactc ctgaacaatc agttattgag gtataaatat gttgaaaatc tctcttctta 1621261 taggagggat ttttttagtt tcagaaaaaa caaaatccct ctggtagagg gattttgatt 1621321 cagcatttta agatgttcta cacgtataat actggagttg atactttaaa aatctcgcca 1621381 tctcttatat aaaaacgagg gatgcggcgg cttaatgtag acacgacttc atagttaatc 1621441 gtattgagca tttcagccac ttcatcaacg gaaatctcgg ctcctttttg cttaccgtaa 1621501 atcacgactt catctccttg tttaccttca ccgttttctc ctaaactgac catgatcata 1621561 tccattgtta ctcttcccgc cactggcact cgttttccgc gatgaagaac aaacccgcga 1621621 ttggaaaggg cacgagaata gccgtcagca tagccaatcg ggagtgtagc aattacttca 1621681 ttaggttctg cgatgtatgt agcaccatag ctaacggttc ggggttctgt ccgcatggtt 1621741 ttcacataag cgatgcgtgc ctttaaactt aacgcaggtt caagcttaac gagatttagt 1621801 tgtttaatat aggctgaagg atataaacca tataagccga tacctaaacg gatcatatca 1621861 gcgctaaatt ccggaaatgc gatagctgca gccgtgttgc acatatgcac ggtgggcagc 1621921 tcaatcccct gtttttttaa aaagctgaga aaactgatga atttttcatg ctgcagcttt 1621981 gtgagtgttg tgtccggttc atcagctgtc gaaaaatgtg tgaaaatccc tgtccatctg 1622041 aggaatttac ttgcctttaa ggctttcact acctctaaaa gttcttcctt tgtgcgtaca 1622101 cctaatcgtc ccatgccggt atccacgtta atatgaatgg ccagccggtt agcactcgct 1622161 tctttttcca atatctcgtt tgcttctttc atccaatcaa cctgaaatgc tgataatgtt 1622221 atattccaag ctgctgactt ctttacacaa ctaagggatg taaaaccaag cacaaggata 1622281 ggtgctgtaa tcccagcttt acgtaaaacg attccttcct ccacactggc aacagcgagc 1622341 tcactcgccc cgtgttccag tgcatggcgt gccacttcta tagacccgtg gccataaccg 1622401 ttcgctttta caacagccat aattttgctc ttatgtggaa tatgacggcg gatcgctcgc 1622461 aaattctttt taacggcatc aagattgact tcgatccaaa cttctcggca aagctttatc 1622521 atcaacgctt ccttccttct tatggattat aaataccacc tattgccgca agaataaatg 1622581 ttaattgttg gatgattcga tcttatttta ttcaacttta tttgaaatca ttcaacagca 1622641 aatccatgtg atacgagaag gtgcctatca atgttcgaat aatagcaagt acgggataca 1622701 tgaggcttgt aagtggggtg ttaatggatg cggcgaccga ggattacaaa aatgattatt 1622761 tgttttggga catttttttc taagggtaga tgataacgag aaatctaatc aggaaatact 1622821 taccgttgtt atgaacattg aagaaccttt taaatgagaa gggctgagga aattctgtaa 1622881 aagataatcg gttgaaaagg cagtcgattc cttgttccat aaacctaaca tcagagtata 1622941 taattatact cgtattcaca aaaatcgttt aagtaagggg tatacatgaa taggggagtt 1623001 agttttcaaa taccgaatga atatggaaat tttctatgga gaatactgca gccggtagaa 1623061 atagctaatt ataggtggca aacgagtggg gaatcttatt ttgttgtaga aggagagctc 1623121 gatgatgagg agctttttca tgactacgaa attgttgagg gggcagtttt tgagcaacaa 1623181 ttaaaaacga atcagtacta taccattttc gttgaactga aagcatttcc atatggaaaa 1623241 atggttaatc aagtcaatac atatgaagag tttgctgaca gtgattgcga acttgtcctt 1623301 ttgatagcag ataatagcta cgtttcgatt tactgtaaaa acaaaaatat cattgaaaaa 1623361 ctttacttca atgctttaca gcatgatttt gaagacgttc aatttataac tgatgaaaat 1623421 gacacaagaa caagccttac tgtatgatac tcaataaaaa ttaaaggagc tagtacatga 1623481 caatgcaaat taaaatcaag tatctagatg aaacacaaac aagaatcagc aaaattgagc 1623541 agggagactg gattgatctt cgggcagctg aagatgtaac aatcaaaaaa gatgaattta 1623601 agcttgtccc attaggtgtt gcaatggagc tgcctgaagg ttacgaagca catgtcgtcc 1623661 ctcgttcaag tacatataag aactttggcg ttattcaaac aaattcaatg ggtgttatcg 1623721 atgagtcata taagggagac aacgatttct ggttctttcc tgcttatgca ttgcgtgata 1623781 ctgaaattaa gaagggtgat cgtatctgcc agtttagaat catgaagaaa atgccggcgg 1623841 ttgaattggt tgaagtcgag catttgggaa acgaggatag aggaggactc ggttcaacag 1623901 gtacgaagta aacaaaataa atccttggct gtcttcatgc tgtgtgattg atcaatggag 1623961 gtttcagcca aggtacatat aaatattatg tataaaatga atattttaat acgaaggatt 1624021 taattaaaaa caaagtttaa aaagggaagt tttgaaaaag tgaaatagta ataactaaag 1624081 tcgataaaga acctaaagat gtcaaagaaa caatttttct ggtgctttgc ttttttgaag 1624141 gtttacttag ctcgtggata actgcccccc ataaaagcat ggatgctaaa attataatac 1624201 ttatatacat aaagatgctc cttttattat atttacagtt tttacatttt tatcgatttt 1624261 accacattta ggattgagtt gtcgatgaaa caagcatctc tataaagaaa tacttttatc 1624321 taaattttta taaatagggg aaggcaacta aaaactagta atgccactaa taataagcca 1624381 agttaaatga cttgtgttca ttaataattg aattttacag cagccatgag cacaaaaaaa 1624441 tctgagttcg tcgataaata tcataaaaaa gcccccggta tgtcgccagg gaataaatag 1624501 acgtttaaga gatttagtga tgttttttat atgattcgac aaaatcataa taatgatcat 1624561 cgtcatcata atactttttt tcgtaatgat aatcgtgatc atcgtaatac tttttatcat 1624621 ggtcatcata ctttttgtcg taatcataat gttttttatc atgatcataa tacttgtcgc 1624681 aatcataatg cttcttatca ttgtcgtaat actttttgta atatgttttt ttccaagtat 1624741 aatactcttc tttatatttt ttataataac ccaattaaat tcctccttta tgttattcga 1624801 atttaattta tgaagtttaa atgatatggt atggtcaaat gaaataagaa tagtaaaaag 1624861 aggctgttta aaacactttc tgaaaaacaa aacggatagc tgtttatgaa aataagagcg 1624921 agagagagca ctcaatcact gtaaaataat agtaaagtgt atagagagat tagtatacgt 1624981 aaaaagggac tttctcattg aagaatattt gaacgttatg gttaagattc aagagctcta 1625041 tgatgtgatt tttcacactg cttttgaagg atttagagtt agacatcaaa aacaaacagc 1625101 aaaaccggct agaaacagat catataagga atgaaccgct gccaaatatc ataaaaaagt 1625161 tgttaatgat caaatgaatg aaattagaga gaatttattt taaagaaagc ccaattgcac 1625221 atggacaaat gacaattgat attgaggtaa aatacaatgc attaaatcag aaaaagctat 1625281 tggaggattt aatgtgttta gacaatttcc aatttggtat acacaaacac ctgactattt 1625341 gaatttttat gtaccgcaat atcaaaccat ttcgtataat cctcaacaat gttatcaacg 1625401 gtgtatgtac caaactggcg gtaactatga gctatgtgac agactatgtt atggagaaat 1625461 acaggtgtaa aagaggggga ttaactcctc tttaaacaca cagtgagtgg aataagatcc 1625521 tcactttatc tgcaagtgct tagtatttgc gataatattg cattcgtaat aaattatgct 1625581 tagcaactga aaatgaaaga aggatatgaa tagtcatgac gcaattcgat aaacaataca 1625641 attcaattat aaaggatatt atcaataatg gaatctcaga cgaagagttt gatgtaagaa 1625701 ccaagtggga ctcagatgga acaccggcac atactctaag tgtaatcagt aagcaaatga 1625761 gattcgacaa ctcagaggtt ccgattttaa cgacaaaaaa ggttgcctgg aaaacagcca 1625821 ttaaagagtt gctctggatt tggcagctga aatctaatga tgttaatgat ttaaacatga 1625881 tgggcgtcca tatttgggat cagtggaaac aagaagacgg aaccatcgga catgcatatg 1625941 gatttcagct ggggaagaaa aacagaagtc taaatggaga aaaagtggat caggtagact 1626001 atcttcttca tcaattgaag aacaatccat cttcacgcag acacattaca atgctgtgga 1626061 atcctgatga attagacgca atggccttaa cgccatgtgt atacgagaca caatggtacg 1626121 ttaaacatgg gaaactccac cttgaggtaa gagcacggag caatgatatg gcattgggaa 1626181 atccattcaa tgtattccag tataatgtgt tgcagcgcat gattgctcaa gtgactggtt 1626241 atgagcttgg tgaatatatc tttaacattg gggattgcca tgtgtacaca cgtcatatag 1626301 acaatttgaa aattcaaatg gaaagagaac agtttgaagc acctgaacta tggatcaatc 1626361 ctgaagtgaa agatttttat gactttacca ttgatgattt caagttaatc aactataaac 1626421 atggggacaa gcttttattt gaggtagcgg tttaatgctg cctttttatt gtgcagtgaa 1626481 tagatagcag gtatcctaat ttcattaagc aatctggaag atgaataaaa attgaaggac 1626541 aaacacgtat aatacataaa aaagattaac tctacagtta atctttttta ttcagaagaa 1626601 aatatcctaa ctttgaaact aaatacaaag taaaagcaat cattacagtt ctagatatta 1626661 caattccatg aatagctaga tcatatccag caggtatcaa cgcatttgta ttacacataa 1626721 aatatataga tattagaagt gctacaataa ctaaaatcat tccaaaaaga cttgtttttt 1626781 catatttcat accaatttcc acccttatta aagttaggtt taaacaaaag agctgaagaa 1626841 acgaactatg accagtatgc tccaaggaaa accgccagac aatgctggcg gctttttgct 1626901 gcttcgttta tttattaaca gagatcgtaa cgttatttcc tgcaactgaa acctttgcga 1626961 aatcctgtgt atctaccaca ggagtgacgg ctttattgtc gatagtgatg ttgttaaaag 1627021 aggtcgaaaa ggttgctttg atcgcatcac gctggctttc atacgaaaca gccgcggtag 1627081 caagtgtttt ccattttgaa atcgtgccga tgttggttcc ttgaatttct gtgataatcc 1627141 gtccggtgta gccgtcattg ttcgttcccc aaagggtcat gcgcgtattg ccgcttaaat 1627201 ttttatagat tgtcatttgg actgtgcttc cagggcggaa gcctttattg tatgtgaatt 1627261 tgtcttttcc ttcgatgtac gtttcttcat ttttggaccc aaccttcatg aggggcttcc 1627321 agacgttgta ttgtttgctg tactgaagcc cgatatcggc ttcagttccg cttgttgccc 1627381 taaagccaga ataaatatag ggagtagaga ccgagtcgtt gtttttgaca gtttcaggaa 1627441 gcacgatttt agctgtaaaa acggcgcccg tactgttcag gtagacacgg ccgccgattc 1627501 cgttaggcag ctcggatgct gcttttgcga cttgagcgtc tgccgcgggt aaacctggta 1627561 tacctgatga aagggttccg aaaagaactg ctgttcctac tgcacctgca atcaatactt 1627621 ttttcaccaa aattccccct tttgatagtg gtttcgccat ttattatacc ttattttgga 1627681 actggattta cgtatataaa tcgacaaaat atttcatttt gaatgatgta aggtcgaaac 1627741 gcttcgccaa tctgaaagct atataccttt atcagaggaa agaatgagat cacattcgtt 1627801 ttaaccgatt tgaaattttc ctcaaaataa aagtacaaat gcttaaagaa acgattatta 1627861 aaagaatgcc cgctatcgtt tccaagcctg taaaaaagag gtgacgtttc atcaatgtct 1627921 gtccttgtaa aatgataaaa gcacagatac cgactaagaa aagaaaacaa atacttagga 1627981 ttgctaacgc tttacgtgag tatgttttca tttcatcttt aaaatacagc aatacgaaaa 1628041 taaagcagat aacattggct attgttctaa tcacctcaaa gcttttcatg acaactgata 1628101 taaatagaca aagtaaaatg agataaaata cgatgtttct atacaaaaaa cctctccttt 1628161 tatgtaggat cctcaaagag tttataaaag tttctttgta actgcaataa attgaatgcg 1628221 ctcacttatg aactaactaa actatgtact aaatattcac tattcttttt cagattcagt 1628281 caccaaggtt ttcatagaaa gggaagcttc agaaatatac atatagtgca caaacaaaaa 1628341 agacccggca atagccgggg gaaagtaaaa acgaggagat gttaatggcg tttagtagtg 1628401 ttttttatgc tttttatact ctacaacata atcatagtct tttttatcgt gatcataata 1628461 ttttttatca tagtcatcat attttttgtc gtaatcacag tcataatctt ttttatcata 1628521 ttcgtaatac ttcttataat acgttttttt gaccgtataa tactcttctt tgtatttttt 1628581 gtaataaccc atatatactc ctcctttatt tttactacgc tttattatac ggcgagtaga 1628641 ttttgcggct tggacagtta aaatcataga aggaaaaaag ggctgtccaa atgatagaaa 1628701 aagacagatg acacaaaaac aaatcaaaat aaagagccga tttttcatcg gcccaaacga 1628761 tttatcctac atttgtttgt cttctttgtt ttctgagtca ttttttctga tatcctgagt 1628821 cagtccgctt gttgcttgtt taaattctga taaggctttt cctgctgcac ggccaagcgc 1628881 cggcagttta tcaggcccaa atactaaaaa acccacaaac aaaataacga gtatttttgt 1628941 gaagcttaat tccatatcct tttccccctg attgaagtac aaccttttaa acaaattata 1629001 agagatagca gtacaaatgg gaatgcattt attttgaaca ttttaaaacc agcacaaaga 1629061 cggattcata aaacggctgc tgctgaatat aatgtccaat gccacctgcc taagaagcag 1629121 gaggcaggct ggatcaatta tgtagctctg ccggaaatga tacaaacgta gcggctatca 1629181 ttgacataga ggagtggtgt agctgatgag attcactaag gtagttggat ttttgtctgt 1629241 tttagggttg gctgcggttt ttccattaac ggcacaagca gaaaaagccg gaactgcggg 1629301 ggctggagag tgggataagt tggggactta cacatatact tactcaagtc cgacggtata 1629361 ctcgaccgga ggagatttta gagtgtgcct ttcaggaagc actccttttt ctgtttcact 1629421 gcacttatat gaggatgatc ccggtgacaa tcctgatgat tatgtagggg caaactattt 1629481 ttcacccgga gaatgccaca cctttggcag tattggaaaa tttgtagatg ggagcaataa 1629541 caaggccgag ttctttgtta ccgattactc tggtaaatct aaaactgtta cgttttatga 1629601 ttgatggact caaattgtga agtataaccc ttggaaaaaa acaaaaaaga gagatacctc 1629661 tctctttttt attcttcgac agccttacga agccgttcat ttacaatgcc agtccagccg 1629721 ccatccatct taccgcgaac gacggagctt ttctcgtttg ctttgccgat cacttcattc 1629781 ggctctttcc agccgctgtg aataagggta aaccctgtct tttcccccaa gtcttctaat 1629841 tgaaaggtaa cgacccatcc ttctgtatcc cattcaaaag aaagttcagt tggagcttga 1629901 acagccaaaa ctttacaagg ggacggccca aacggcgatt gtaagtgaaa ttcttgtcct 1629961 tctttgagct gaaagtcatt gggcataaac cacttggcaa tgccttctga agtagagact 1630021 gtctcccaga ctttctgaat gggagcctcc agagtaatgc tttttgtaat atccggtaat 1630081 gcattttcgt tgttttgagc catttcgttt acctcttgac atatgatgtt ttttcaattc 1630141 aatcatataa taactaataa gatcatgtcc atagcgtgca ttatttatgc tagagctgct 1630201 gttgaacagc gtgtcagtcg ccagtctgat ctgtgaatgg gagaattctg catgcgcgaa 1630261 aaagagagag aggtgtatgt tgtcatttcg ttcattcttg tttgcagccg caactgttat 1630321 gtttgaactg ggattcctgt tcagccaatt tattttgcga tttttgtttt aatagtaaat 1630381 gagccatttt ctaaaacagg aggtttttta tgcttggaaa aatcaaagca gccattgata 1630441 atagtccagg gaagccggcc agaattttag ttagtgaaaa agcgtttcag caattagagg 1630501 aagaaatgcg ctttgtttac gtttccaaac cgaaaacgat aatggggatt cctgtggaag 1630561 tttcagatca ggcagaaagc ttcaagctgg aattttagtt ttcccagact gctaaaaggc 1630621 tcattttgtg ttaattatgc aaaatggtca ggttgatttc tttaaaagca tgatgaaatg 1630681 ttcatcatgc ttttttattg agaaaaaaga cgaacataaa aaataggtat acgggaaaaa 1630741 taatcctatt agagagaggg gaactgacag atggataaca tgatatcaac acttactgac 1630801 tggaatgtgt ggtttcaagc gttagtagta tttctcgttc catatgtaat ctataaagtg 1630861 tttacttgga ttcatgtata agaaggtgca atgatgaggt ggcggaacaa tcagtacaaa 1630921 acacagaagc agcataaatc agattattcg acagctgaaa agcaggatca ggatgtgtta 1630981 accggtaaca tcggatacga cttagaacat gtaaaaagaa aaataggaca taacggggac 1631041 gttcatttcc gtgagcttga aatcactcaa ttacatgtga aagcggcatt gatctttgtt 1631101 gaaggactgt ctgatcagga cttgattaat aaaggactat cagtgttagt catgaatcaa 1631161 cctaatcagg taagcgatga aatttctcaa tccggcaaag gtattttaac ttcgaaacag 1631221 ataaaaaatc aaatcgtatc aatcggtgat gtcatagatt cagagaaaat cagtgatatc 1631281 gtgttgaatg ttttcatggg ttcgacagcg cttctcatcg atggaatacc gcaggccttt 1631341 cttctgggaa ctgtaaaaaa acaaaatcga agtatcgagg agccgctttc agaagcgctt 1631401 gtcagagggc cgcgcacagg ctttacagaa gagttgagta cgaatacagc tcttttgaga 1631461 cagcaaggaa aaaatgatca attaacattg cagagatttg aagtaggaac acgattaaaa 1631521 aaggatttaa ttatcgctta tatgaatgac attgcagatc caaaagtagt cgaggaagta 1631581 agaaaaagag tgagagggat tgagatcgat catttgccgg agtcaggcta cgttgaacag 1631641 ttaattgagg ataattattt gagcccgttc ccgcaagtac agagtacaga acgtcctgat 1631701 cgcgtcataa gcggattaat ggaaggaaga gtagctattc tgcttgacgg cactccgttt 1631761 gctttgattg ttccagtcac tttcagcatg atgcttcaat cgcctgaaga ttattatgaa 1631821 cggtggttcc cgagctcgct catcagattg ctgaggttca tcgcagcaat gataacgtta 1631881 ttcgcacccg ctttatatat atcatttatt tcttttcatc ctgggttaat tccgaccaag 1631941 ctggcgattt caatttccgg gacgcgccaa ggtgttccgt tcccatctct gattgaagcc 1632001 ttatttatgg aagtcgcgat tgaaatttta agagaggcgg ggcttcgttt gccaaaacca 1632061 attggacccg caataggcat agttggcgga ttaatcatcg gggaagcagc tgtgcaggcg 1632121 gggattgtca gtccaatcat ggtcattgtt gttgcgctca cagcaatttc ttcatttgcc 1632181 atcccgcatt atagcacagg tatagcactt cggatgcttc ggtttggcgc gatgttttgt 1632241 gcggcggtgt ttggattgtt tggagtcatt atgtattatc tgctgctaag cagccatgtc 1632301 gtaaagctaa agagctttgg tgtgccatac gcaagtccgg cagtgcccta tcacttaaaa 1632361 gattggaaag actttgttat cagaatgcct cttttagtca tgaagcgccg gcctaaaatg 1632421 atgaatacag ataatacaaa acgggtgaag tgatgaactc gacaggatgg tgataaagtc 1632481 tcatgttcag cccaaccagt aaaatcacaa ccgctcaggc aacgattatc atcattaatt 1632541 atatgcttgc tgccggagtt cttacgctcc ctcggacagt aacagaacaa acacaatctc 1632601 ctgatggatg gatttcagtt ttattaggcg gggtcctagc ggtaatagcc gggatgatta 1632661 tagctaaatt aagccagcag tatcctaagg agacctttta tgaatactcc cgacatattg 1632721 taggaaaatg gctcgggcat ctgatcagta ttgtttttat tacttatttt ctggcactcg 1632781 gtgcatttga agtcagagtc atgtccgaaa tcgtggattt ttttctcctc gaagggacac 1632841 cttcttgggc catcattatg acagttcttt ggattgggct ttattcaatt acacaaggcc 1632901 tagatccgat tgcacggctt tttgaaatga tttttccgat tacggtcatc atctttttaa 1632961 cgatagccct catgagttta ggcatatttg agatcaacaa tttgcgccct gtattaggtg 1633021 atggaatcat gccggttctt agaggtgtaa agacaacgaa cctttcattt acatgttcag 1633081 aaattatgtt cattttagta gcatttatga aaaagccgaa aaatgcggtg aaagcagttg 1633141 tgatcgggac aggcgttgtg accagttttt atatgattac gatgattatg gtcatcggtg 1633201 cactatcagt tgagggagtt gtgacgagaa catggccggg gcttgacctg atgagaagtt 1633261 ttgaaatacc tggtttaata tttgaacggt ttgaatcatt tctgcttgtg atttggatta 1633321 tgcagctttt tgccacgttt attatcactt tttatgcagc ttccctggga gtctcacaag 1633381 tttttaaaaa gaaacccctt tcatgtatgt ttgggctgct tcctgttata tatatcctct 1633441 cttgcatgcc gaaaaatgaa aatgacgtct ttatattggg cgatacggtc agtcatatcg 1633501 ctttgtatat atttggcgct ttgccgattt tgctgttagt catttcgaaa tggaggaaaa 1633561 gaggtgaaaa gtaaactaaa acgtcaattg cctgctatgg tcatagtatg tctgctgatg 1633621 atttgcgtaa caggatgctg gagcagtcgg gaaatagaag atctgggtct cacattcgct 1633681 atcgcaattg ataaaggaaa agaaacgaac actgaaaaag agttaaaaga agagggcggg 1633741 agctatccga aaaaagacaa cattacgctg acctatcaat ttgttaatga aaaagcggca 1633801 ggcgcgggca caagcggggg aggcggtagc ggacaaggag cgcaaaaagc gtacattaat 1633861 ataagtgaaa caggggattc attacagcag atcggaagtg aggttgcatt aagacgggac 1633921 cgagaagtgt ttagcccgca tttaaaagtt gttgtcatga gtgaagatgt gctgcacaca 1633981 tttcctatcg acgaaatgct ggatcaattt tttcgtgata atgaaatcag gctgagctgt 1634041 cttgttttat ctgctaaagg ggaagcaaga gacgctctcc agctgaaaga gaacggagaa 1634101 attccggcat ttcggctgat tggattaggt gaaaatgaac ataaagtttc cagaattctt 1634161 ccccctatga cactcgcgaa actaattgga aaactgcatt ctggcagcag ctttttactg 1634221 caaaatgtgg ttgcggcgaa tggagcggtc aagtattccg gagcagctgt aatcaacgga 1634281 aaatcgaaaa aaatgatagg caccttaaat gaatatgaaa ctgaggggat tacatggatt 1634341 agaggagaag ggaaaggcgg agttgtcaaa agtcatgata aaaagagcca acagacgtta 1634401 gcgtacgata tcaataaaat caaaagcaga attcagccaa tcgtaaaagg gaaagatatt 1634461 tcattccatg tcgatattga atcagaaggc gatttggttg aaaactggaa cacaaaagag 1634521 gcgttggaca cccagtttat agatcgtctc gaaacgacta ttgaaaacga ggtaaagaaa 1634581 atagttggtc aggtattaaa aaaaattcag catgattata aagcagatgt tgcgggtttt 1634641 gatgaatctt ttagacttac atatcctcac ttatggaaaa gggtgaaaaa taactgggat 1634701 gacaccttca gtaaagccga catcacatac agtgtgaacg tcacaattac tcatttcggc 1634761 acggttaaaa ctcagtaatg aatcccaagg aagagaagga aacctctctt ctctttttta 1634821 tgcatttatt aggataaaga tacttttttt ggagagatat acacttttca aatcgaccaa 1634881 tatgctaata taggaattgc ttgaaataga agggagaagg ggctgtgagg cagaaaccga 1634941 tttatgtaga aatcgaaatg aaatctgatc tggatacact ctgggaatat acacaaaacc 1635001 catcactgca taaggaatgg gatctccggt tttcaaatat tacgtatttg aatagtcagc 1635061 catgcgaaaa acagaagttt ctttacgaaa caagggtagg ctttggatta aaggtgtcag 1635121 gtacaggaga aaccgtcggt gttttcaaca aatgttcatc tgaaaggtct tcttcactgg 1635181 cttttggctc tgatcatcca ttatctctga ttcggcatgg aagcggctac tggaagtata 1635241 tacagagaga aaatgggaaa atgacgtttt taacacagta ccaatacaaa acagcctacg 1635301 gactgctggg aagatggatt gatcgtttat tatttcggcc gctgcttggc tgggcgactg 1635361 cctggagctt tgatgcatta aggctttggg tagagcaaaa taaacatccg aagcgcttca 1635421 ttcgatctgc tatcatctat gtgttcatgt gtctgttttt cagcctgttt tggttctatc 1635481 aaggctttgc aggtgttaag acaagcatat tgacaggaac agcggagata ggcttagcta 1635541 ttttgtggct gcttccttta aaaagaaaat ggatcattca tggtgtccag gcttgtattt 1635601 ttgctgggtt tgcttgtcta ggttccgaaa tattcatgtg ggttctattg agtgtgtttt 1635661 ccgctgcaag cggcgctctt agcctgcagc tccccagtgc caggcgcaca aaacgaaaga 1635721 gaaagaagtg acattgtgag ttcgatttat gaaaaatcaa ttattaacta tcatttgctg 1635781 catcccaagc tgcagaaacg gtaccaatta gacgggtctc atacattcag cgggacggga 1635841 acgatgtcag aaataagcgg aggctctttt ctggttagaa tgctgttaaa gctgggtgtt 1635901 tttttcagat gcttcttttc agaaagaggc aaagacattc catttacaat acaaaataga 1635961 acttgtcttt tgaaatcgca acatacagga atagaatgga atcgtacatt tttctttaaa 1636021 ggcaaaaaac gtttctttga tgcgttaatg atatatgacg agaaagaaaa tagaatactt 1636081 gatttcttcg gcaaacctca tctgctgctg tctgttttga cgttcgaggc atctcttgac 1636141 ggctctctta cgatcacatc gggaaagcaa tggctattga tatgcggaaa aagaatcccg 1636201 ctgccgaaat ggctgaccgg tacatccgaa gtttgcgaaa cgtttgatga aaaaaagaat 1636261 tgtttcacca ttgaagtgca tgtgcaaaat acaattcttg gcactctttt cttttataag 1636321 ggaacgtttc aggaggaaga gagagaatca tgaaacgaaa tggcatagtc agtgcgcttt 1636381 gttttattgg atttcttgca gcagaagcac cggatatttc agtggcagag gcactcgttt 1636441 tgttatccat tctatttttc gtgccgggaa tttttccttt tgtttttcgt caatctccgg 1636501 ttcgtgctgc tcagtttatg gaaaacgggc taatccagtg ctatcctgta gccgcattct 1636561 ttgcggtgct ggctctagtg acggaggttg ggggtttcgc acttatctgg tggatgtaca 1636621 cagtttttaa tgcattgtat gcgatcctcc gcctttggga aacaaagata catagaatcg 1636681 aagagacatc agttttgttc ggtcttattt atttggcggg aggaggattt tggttttttg 1636741 cttatgctgc ccatttgcag atcatgcaat ttggccctct catcattttg ctgactgctg 1636801 tccactttca ctattctgct tttctgatcc cgatcttcaa cggtttactc ggcagaacca 1636861 ttagaaaaca tcggatgttg tacagttgga taacatgggt gattttgctt tcgccccttc 1636921 ttatcgcact gggcatcaca tattcaaaaa cacttgatgt cattgcggtt agcatttata 1636981 tggcggcgat ttatcttcat gcatttttgg tgttcacggc agcttttcgc accaagacgg 1637041 ggacatttct tattcggctt tcttccgctg ttttaatgat aacgattgct ttctcgatga 1637101 tttattcatt tggtgtcttt cggcaagaag ttacattgac catcaatcag atgatttgga 1637161 ttcacggttt tgtcaacgcg tttggtgtta tcttgcccgc tctcataggg tggagaatag 1637221 aggatgcgaa accttttgat gcagacagtg taaagacatt cagccgtatc tacggaaaaa 1637281 gaaagattgg agaagaattt ttagctaaca ttcaagctga aaataacgct cggtacagcg 1637341 gacttgtgga tgatatgggc agcctgcgtt caaaagattt ttcaccagaa aaactggcgc 1637401 cgctcattct ttcgttttat gaacaaacca tcgaatacaa tattaaagca aaagtaacat 1637461 ggagcacgtg gtttcggccg cttgcaatta tttacgaatg gttcagcaga agaatcggcc 1637521 aaatacatct ttcgacgaac cctgactggt ataggatgta cagcaagata aaaggtgttc 1637581 attcgaaaaa agacggaagg gaaagagtac gtgcctggat tagaacaaat gaaaaaaacg 1637641 aaaccatttt taccgctctt tattcagtgt atcgttcaaa tggagagggg tatatgaata 1637701 tttctttacc gcttccattc agcagcatga caggtatttt aaaaccatat catcatcagg 1637761 agaagctggt tttaacaagc aggcggagaa aaagcagagc gggggatgag gggatttatc 1637821 tgcaaacaag agcgggaact tgtccgcttc ctttatctga aacctttctg atagaagctg 1637881 tacatgacaa caaattaacc gctgttcatc atatgtggct gtttggaata aaatttctaa 1637941 ctgttcatta cagcattaca catattaacc agcctattga aagaacctaa cacaaagaag 1638001 aagcttcgtc tgccagttgt aatgagatga actgttttaa aattctgcac cgcatcaaga 1638061 caggaaagga agggtttatg gtgttttata tcagtttatt tctgattctt tggctggctg 1638121 ctgggtttgc agtgggaatg aaacaagtgt atgtcgatca gctgtttgat aaagctgtga 1638181 tcgaaagact ggaaaaagaa gcgaatgatc atggacatgc tgaccggatg atcaaacagc 1638241 gcgtccttta tattgcagca gtgacagtaa gcgggtttat ttctgtttat tatgaaatga 1638301 aaacaatccc gcaaaggcga aacataagaa aaattgaaaa aaacatcatg aaattaaatc 1638361 aagcaaaaaa acgaagaatg aagagaaaat aaaaagtgca caggccaaag ggcaggtgca 1638421 tttttgtttt gtatggaaaa tgggggaggt ggtgccagct tacttttcat aaattcaaaa 1638481 atgagaagaa cagcgcccgg gctaatggta tataatattg tgaatttaac aaaaatttaa 1638541 caaggaggac gagagaattc gtgctaaagc ctcaaagaga cctacattct gttgatttgg 1638601 acttagaggc ggagtagatg aaaccggcca aagtatccct gctccgccgt ttgctccatt 1638661 ccttgaagca tgttgattgt aacatagcca aacgttttcc atcaactatt aaaattgtaa 1638721 aattattgat gatttttatg gtgtttactc cgatttcttc aatttatgct gaagatgtat 1638781 atcagaattt tgaggaatta aaaaacaatg aagatccttc tgattatggc gttgttacga 1638841 aagaaaccgg aagccctgtt cttgttttag ctattcacgg aggaggtatt gaaggcggga 1638901 caagtgaagt agcgagagag ctcagcaaag agtactcgat gtatttattt gaaggcttaa 1638961 aatcggcagg aaactcagtc ctgcacatta cgagcacaca ctttgatgaa cctcgggccc 1639021 ttaaaatgac gggaaatcat gaatatgtca tttcattaca cgggtacgca gaagaagatc 1639081 agcagatcga agtcggcggt acagatcgcg taagagcggc agatttagtt gagaaattgc 1639141 agcatgccgg ttttcctgct gtattgctca atatggacca tccgcatgcg ggcgttagtc 1639201 cgaataacat tgcaaataaa tcaaaaacag gtttaagtat tcagatagaa atgagcacag 1639261 ggtttcgaaa gtctttgttc ggcatctttt ctttaaaaag cagagctgtt actcaaaatg 1639321 agaggtttta tgagtttaca gaagtgatgt tccgttttct caaaaatagc tactgaaaaa 1639381 taggaggcga taagacagcc tcctattcct tatgcttctc tttcgtttcg ggaaacagct 1639441 cgtccgcggc ttccgtttga tactgcaacg tgttatctct cgctgacagt tcatttcgga 1639501 aattttcatc aagcacattt ttcagtaaat accgatgaaa aaagtattca aaaacagtaa 1639561 gacaggcagc ggaaaggaga gccgctccaa atggtgagaa atcgtttctt gtttgggtta 1639621 aaacaaatac ccaaagaata acgaatgaaa ggccaaagtc agccaatgaa gctgtaatat 1639681 tgtttgttct gggtaagacg agcatgtcac cagaaagata ggaaacaaaa cctaagaaaa 1639741 gtgcaataaa catcacactt aaaaaggatg cgtgatagac tctgtccaaa atcacatata 1639801 aaagggcgag agtgaaagca atctttgaag caagcgcaat gatatgtttc atttgaccac 1639861 ctaaattgtt attttttgaa gaaaattctt gggcgtaaac aaatgataaa taatgcaatt 1639921 caaaaccatt cataatggtc atgttactat tttaaacagt ccgtttttgt ttacactggt 1639981 atttttttca gctgtatgaa actttcttat gaaaaaagtc gtatatgtgg atgatcagct 1640041 ttcaaggggg gaatgatttg tggagataaa aggaatcaat cacttgctat tttcagtttc 1640101 gcatttggat acatcgattg atttttatca aaaagtgttt ggtgcaaagc ttttggtaaa 1640161 gggaagaaca actgcatatt ttgatatgaa cggcatctgg ctagcgctta atgaagaacc 1640221 agacatcccg agaaatgaca ttaagctttc ttatacccat attgctttta caattgaaga 1640281 tcatgaattt gaggagatgt cagctaaatt aaaaagactt catgtcaata ttctgcctgg 1640341 cagagaacga gatgaacgcg atcgaaaatc aatttatttt accgaccctg acggccacaa 1640401 atttgaattt cataccggaa cccttcaaga caggcttcga tattacaaac aagaaaaaac 1640461 gcatatgcac ttttatgatg aaacggcctt ttgatagcac aaccatattt catataaggt 1640521 taaatttaaa gaagggtgtt ggtggagact ttatgtttgg ggaaggtttc tacccgactt 1640581 gttcaacgat gccatatctt ttgaactgca caagtgattg ggtgaaggtg aaattgaaat 1640641 acacattaca ttacatttta tatgaagaaa gcgagctgtt ttatcaaatg ttgaactaat 1640701 taaactatgt actaaatttt cagtatattt caattgcttt gccccttaat aaatataaaa 1640761 ccgcatcctt ccacgaccta aaaaatgaaa cgtttttaag aagatggcgt ctaatattct 1640821 aaatgttcat attttgataa aagtttccta aaggaaagaa aatttcttga cttcaacaat 1640881 cttttggtgg ataattatgg tgtaaacatg atgttctttt tcctcctatt cgggctcgca 1640941 cccaaaagtc agggcgagcc tgcttttttt gaacaacaaa ccccctctcc gtaaaggaag 1641001 agggggttat tttatgcatc tgatagatca atagattaat ggacggttct gaacacgcca 1641061 atcactttcc ctagaatgct gacattctgc aaaatgatag gttccatcgt tgggttctca 1641121 ggctgcaagc gaatgtgggt atcctcttta tagaatcgtt ttacagttgc ttcatcatct 1641181 tctgtcatcg caactacaat ttccccattg ttcgctgtgt tttgctgttt aacgatgaca 1641241 tagtccttat cgagaatacc agcatctatc atactgtctc ccataatctc cagcataaat 1641301 acatgctcgt ctggaggaac catgcggtca gggagcggaa aatattcttc aatattttct 1641361 actgctgtaa taggagatcc cgccgtgact ttcccgatga ccggtacatt aacgacctgg 1641421 ctttgcggaa tgtctacttc ttcatcaaga atttctattg ctcttggttt tgtcggatct 1641481 cgtctgatca gcccttttgt ttccaaacgg gccaaatggc cgtggacagt agaactggac 1641541 gcaagcccga cagcctctcc gatctctctc acggaaggcg gatatccttt tgatttaacc 1641601 tctgctttaa taaaacggag gatatcaagt tgcctttttg atagcttcgt catttttcgc 1641661 acctcaaaac gtcgatttta agaagattat agcatgattt tccttacagt acaaacatag 1641721 gttcgaaaaa acaattgaca gaaacgtttg ttcgtatata ctgaaattat aaaaatgcga 1641781 acaaacattc ctgttggagg ttatgatcat gagtaaagaa tctattattt ttgtcggtct 1641841 gtttacagtg attttgagcg cggttatcct tatgctgtca tatacaagca gcggccaaga 1641901 gcttaatcag tatgttaaaa tagaagtcca gcaaggcgac acactctggt caattgctga 1641961 tcaggtagcc gatacaaaaa agataaacaa aaatgatttt attgaatggg tagctgataa 1642021 aaatcaactt caaacctctg atatccagcc gggtgatgag ttagtgatcc cattgaaaaa 1642081 gaagcatcag gatgcatatg aattagcaac tgtaagatag agaggaaaga gagataaaat 1642141 gaaagcactc atttatgccc gtgtaagcac aaataaagaa cagcaggaaa cgtcattaaa 1642201 gcggcaggag gaggagctta cggccattgc agcggagaac ggcatggaag tggtcaaagt 1642261 gatttcagaa aaagccagcg gatatgaaat ggatcgggat ggtgtatttg agctgctcga 1642321 tgagattaag aacgctgata ttgatgtcat tttggttcag gatgagacaa ggctcggacg 1642381 gggaaacgca aaaatcgcac tgcttcattg tatttataga gaaggtgtga aagtctatac 1642441 aacggctcat agaggtgaac tggagttatc ggaggctgac tcaatggtct tggaaatcgt 1642501 cagcattgtg gaagagtatc agcgaaagat tcacaacatg aaaatcagac ggggaatgaa 1642561 acgtgcagta aaaaacggtt ttaaaccgca aaaaaactta aaaaaccaac atgggaacag 1642621 tggaaaagaa aaaatagagg tgccaatctc agagatcgtc cgcctgagag cgaataaact 1642681 gacgtttgct gaaatcgcgg ctaccctaag agggtttggc tatgatgtct ctaaagcaac 1642741 cgttcaccgg cgttttcagg aatacataga gaatgaagag actgcagagt gaatcagttg 1642801 taaaactttt tttgatctag tactatatag acaaaatgca ataaaggagt ttaacatgat 1642861 ttcaaacgcg aaaattgcca gaattaatga acttgctgcc aaagctaaag ctggcgttat 1642921 tacagaagaa gaaaaagccg aacagcaaaa gctccgtcaa gagtacttga aaggttttcg 1642981 ttcttctatg aagaacacgt taaaaagtgt gaaaatcatt gacccagaag gcaatgatgt 1643041 tacaccagaa aagctaaaaa gagaacaaag aaataacaaa cttcactaat ataagaggaa 1643101 tacggcaata tcgtattcct cttttgcata tactataatc aaaactctta tgtgacaaaa 1643161 ttcaacaagt ttctctcaaa tttaagctga aacagttgag aaaaagtcgt cagacattta 1643221 tgatgtaagg gtacaacaca taaggaaggg gatttttatg gatacaattg aaaagaaatc 1643281 agttgctacc attcgcacac tgtcaataga cgctattgaa aaagcaaatt ctggtcaccc 1643341 agggatgccg atgggagccg ctccaatggc atacacgctg tggacaaaat ttatgaacgt 1643401 aagtccggca aaccctggct ggtttaaccg tgaccgtttt gttttatctg ctggacacgg 1643461 gtcagcacta ttatacagca tgcttcattt aagcgggttt gatcttagta ttgaagatct 1643521 taagggattc cgccagtggg gcagcaaaac accaggacat ccggaattcg gacatactgc 1643581 cggtgttgat gctacaacag gtccgcttgg ccaaggaatt gccatggcag tcggtatggc 1643641 aattgctgaa cgccatttag cggaaacata caaccgcgat tcatttaacg tagtcgatca 1643701 ttatacatac agtatttgcg gtgatggtga tttaatggaa ggtatttctt ctgaagccgc 1643761 ttcactcgca ggccatcttc agcttggccg tctgatcgta ctatacgatt ctaatgacat 1643821 ctctcttgat ggagacctcg accgttcatt ctctgaaaac gtgaaacagc gttttgaagc 1643881 aatgaattgg gaagttcttt atgttgagga tggaaacaat attgaagaat taacagcggc 1643941 tatcgaaaaa gcacgccaaa atgaaaagaa acctacatta attgaagtga aaacgacaat 1644001 cggattcggt tcacctaacc gtgccggtac atccggtgtt cacggtgcgc cgcttggtaa 1644061 agaagaaagc aaattaacaa aagaagctta cgcgtggaca tatgaagaag acttctacgt 1644121 tccgtcagaa gtttatgagc atttcgctgt agctgttaaa gaatcaggtg agaaaaaaga 1644181 acaagaatgg aatgctcaat tcgctaaata taaagaagtt tatcctgaac ttgctgaaca 1644241 gcttgaactg gcaatcaaag gagagcttcc gaaggactgg gatcaagagg ttcctgtgta 1644301 tgaaaaagga agcagtttgg catcccgtgc atcttccggt gaagttctca acggacttgc 1644361 gaaaaaaatt cctttctttg tcggaggttc tgctgaccta gcgggatcga acaaaacgac 1644421 tattaaaaat gccggtgatt ttacagcggt tgattactca ggcaaaaact tctggtttgg 1644481 tgtacgtgaa tttgcgatgg gtgcggcctt aaacggtatg gcgcttcatg gcggtcttcg 1644541 tgtattcggc ggaactttct ttgtcttctc tgattacctg cgtcctgcga ttcgccttgc 1644601 agcgttaatg ggccttcctg tgacatatgt cttcacacat gacagtattg cggttggtga 1644661 agacggtccg acgcacgagc ctgttgaaca gcttgcttca ctccgtgcga tgcctaacct 1644721 ttctttgatc cgtccagcag acggcaatga gacagcagca gcatggaagc ttgcagtgca 1644781 aagcactgac cacccaacag cgctagtgct tacacgtcaa aaccttccta ccatcgatca 1644841 aacatctgaa gaagcattgg caggagtaga aaaaggtgca tatgtcgttt ctaaatctaa 1644901 aaacgaaaca cctgacgctc ttctcatcgc ttccggatca gaggtaggtc ttgcaattga 1644961 agcgcaggct gaattggcaa aagaaaatat cgatgtttct gttgtcagca tgccttcaat 1645021 ggaccgtttt gagaaacaat ctgatgaata caaaaacgaa gtccttcctg cagatgtgaa 1645081 aaaacgtctt gcaattgaaa tgggctcatc atttggatgg ggcaaataca cggggcttga 1645141 aggtgacgtt ctcggcatag accgattcgg tgcatctgct cctggtgaaa ccatcattaa 1645201 cgaatacggc ttctcagttc cgaacgtagt gaatcgagtt aaggcattaa tcaataagta 1645261 agcttttgaa agaggatgag tcaaatcatc ctctttttct tgtttatccg acaaaaatag 1645321 tattggctgt ttaacagtaa tagacaattc tttcttttct tcttttgtat aatagagagc 1645381 aaatgaaatg ctgctggaaa aggggatgaa aagatggaac gtcactacta tacgtacctg 1645441 atcaaagagg aatttgccaa tcactatttc ggccgggaat cggttatgtt tgagctgttt 1645501 caagactatc attggacaag ccttgaaaag cagcagtatg aaatgacaga gaaacagatt 1645561 caatatatta cacaaccaat cccgatttta catatgcatc agcggttaaa aatgaattta 1645621 aacaagacgg attacaggca gctggattat atttatagaa tagctttgcc gaaagcaaaa 1645681 ggccacgcga cgtttatgat gaaggagcac atgatagaaa ttgtggcttc gggagattac 1645741 gaggcagaaa cgatattctt tgaagtgtta agaaaagtaa gcccttgctt tttagcaatg 1645801 gatttcaatt cgaagcgtta cggatggcta aatccggtga aagaaagaaa ttttgtctaa 1645861 aaccgaagaa aaagagatgt aaatgttgta taatagcttt tggtttagta cactttaaac 1645921 tagacaacat gaaggaggaa ataaaatgac tttatgggtt ggcatcctag tgggcgttgt 1645981 tgcattgctc ataggtgttg cactcgggtt ttttattgct cgtaaatata tgatgagcta 1646041 cctgaaaaag aatccgccta ttaatgaaca aatgttacgc atgatgatga tgcaaatggg 1646101 aatgaaacct tctcaaaaga aaatcaatca aatgatgaaa gccatgaata atcaaacgaa 1646161 ataatacgta aagattatga tatagagaaa catggttata aaataaaaaa cccttatacg 1646221 ggttttttat tttgcaatca ttcatcaccc gctactgctc gaaggcgctg cttttgatat 1646281 tgtatgagaa gatggtcaag ctcctgactg agctctatcg taatatgaga tgtcattccg 1646341 ttcgccatga caatttgcag cagctctgct cttttttttt caatttcttt taatagatgc 1646401 tctctaatca cagggatgta tcctttcata cattagatct tcaaagtgaa tgtttatatt 1646461 atatccatat ttatactaat tttcaaatga gaaggagtat aatgtctcaa tgtcaaatta 1646521 aattatataa gttttttctg aaaatagaaa tccttcaagt gaaagtgtta aaaaaatgaa 1646581 atgattttgt cataacttga aggaatgtca aatcatgaag ggatgatgac atgggagacg 1646641 tgaattattt tttgacattc ggagcggggt ttttatcctt tatttcgcct tgctgcctgc 1646701 cgctttaccc agcttttttg tcatatatta caggggtcag catggacgat gtaaaaactg 1646761 aaaagctgct gctgcagaaa agaagcttgt ttcatacttt gtgttttttg cttggctttt 1646821 cagtcatttt tattgcttta ggctatggaa catcttttat tggcagcctg tttagggatt 1646881 atcacgatgc gattcggcaa attggcgcgt tgcttattat tttgttcggt ttcattacac 1646941 tcggtgtgtt ccggcctgag gctatgatga aagagcggag aatccatttt aagcataaac 1647001 caagcgggtt tttagggtcg gtcttaatcg gaatggcatt tgcagctgga tggacaccat 1647061 gtaccggtcc gatattagct gctgttatca cacttgcagg caccaatccg ggctcagcgg 1647121 tgccatacat gatgttatat gtactcggtt ttgcggtacc gtttctttta ttgtcttttt 1647181 ttatcacaaa gctgaagtgg ataaggaaga accagctttt cattatgaaa gctggtggcg 1647241 ttttgatgat tgtgattggt gtgctgttat tctttaattg gatgagcctg atcattattt 1647301 tgctgtcaga tctttttgga ggctttactg gtttttgacg gtaaattact ttcgtactac 1647361 tactaatcct tttgtttttg gtacaataag actattatct gtggaaatcg attgttggag 1647421 gggaatatga caagagtttt agttgtagac gacgccaagt tcatgagagt gaaaatcaga 1647481 gagatcttgg aagaggcaaa ttacataatc gcaggcgaag cggcggacgg tgaacaagca 1647541 gctgacctgt ataaaaaact gcgcccggac cttgtgacaa tggatattac aatgccggtg 1647601 aaaaacggca taaaagcgct tcgtgatatc ttaacctttg atcctaaagc gaaggtcatc 1647661 atgtgcaccg ccatgcgcca gcaaagaatt gtaacggaag caattgagct gggggcaaag 1647721 gattttattg ttaagccgtt tgaggaaaca aaagtgctgg aagctgtaag ccgcgttatg 1647781 ggacattaaa gtcatttctt ttcaaaatgg ttttttttat tgttttggag tatagtatat 1647841 agtatcaaca ctccgagaaa caaaggaatg ataagtatga tgattatagt ttcatcaatt 1647901 attgctgtgt taatggctgt agctgtgatg gtggtcagaa taaagtcctc tgacaagcct 1647961 gtttcaccaa aaaaaatcat tcttccgccg atttttatga gtacgggagc gttaatgttt 1648021 ttatttccgg tattttgggt aactggagca gagtttttgg aagcattcac tttaggtgtg 1648081 attttctcta tttttctaat caaaacttct aagttcgaaa ttaaaaataa tgaaatttac 1648141 atgaaacgct ctaaagcatt tgtttttata ttagtcggtc ttttggtgat cagaatcgtg 1648201 atgaaatcga tcttgagcac atcaattgat tatggtgcac tgagcggaat gttttggatt 1648261 ctggctttcg gtatgattgt gccttggaga atcgccatgt atttatcata tcgaaaactt 1648321 cataacgagc tgcagtcatc taatattcaa atgaattaaa aaacctttcc tcttgtcagg 1648381 aaaggttttt tatttgagaa gggtctgata aggttccaaa tcgatttttt tgtcccgcag 1648441 atgccttttt aagaaggtat ggtctctttt aggagttgcg agaatatagc ctttgatcat 1648501 aagttgctga tcaatctttg ctaccttttc ttttaatgca agctcaccga ttttgcctgc 1648561 gattttagct tttgctgcat ctctgaacag ctctggcacg ggcgcagtca attcatctag 1648621 aaactgtttg ttttcatcgt tccataaatg tctgctgttt tcaatatagt aatcctgcca 1648681 atcaagctct gatctgccgt cctcttttgg taaacgcttt aaaaactttc gaaacatgaa 1648741 aaaaccgccg attgataata agactaccat catgattacc caaaacagaa taaaccataa 1648801 aaaccatcct tccagcatca atcattcccc cttattctaa ccatattgta tacgaagaga 1648861 gattagaaga acacagtaaa aaaagaatag aaaaaagtga tagacgtcta gtcaaaagag 1648921 atagtagatc atattctatt gtatagtgaa tctgctattt ggccatggga gagtcactag 1648981 agggtatttg acgataaatg gacggaaaaa aagtcacttt cataataggg gatgaaagtg 1649041 actttttatg tttagctgag aggaaattga agagaaaaag aagagccatc ttctgtttct 1649101 ttattgacgg cgactgtgag tatttgattt tcgcattcga cttgaatgtt tttgtcatta 1649161 aaataaaaag gaagcatcat ttgtttttca aaagtctgtc ctgacgattt gacagttaag 1649221 atgaactcgc atccagaaag ggtaactgtt acttgtgtag gctgtaaaaa agtcagatcc 1649281 gcttctataa tatactgctg acttgtttca tataaatcaa taggcaatgt ttcgtcgtac 1649341 caggcgaagg ggtcttcaaa aaattgccga agccattcat ccatactatc gaaatcattc 1649401 gcatcgttgc gttttgaatg gttcatggaa gcattcctcc acatatcaac cttgctttac 1649461 atcatatgcg gtggattata aatgggtgaa cgcataaaaa aacagacact aaggtctgct 1649521 tttcttacat atcatggctt gagttgtgct tttgtcttgt atggtttcgg ttttttactt 1649581 ttttgcttcc gcttagaggc tcgggttggc cgggattgtg tcctttaggg gcgtttttat 1649641 gcatatcttt acttgtattc ttattggtca taaaatgaga acctccttaa aagagttcgg 1649701 tgttattgat tggtttttct ttttttgtta ttttggcgtt ctgcttcagt cagtacaagc 1649761 tggtcgtttt caatatagcc ggcgcctttg ccttggcttt ttgcgtcatt cattccgtta 1649821 atgacgtgat tcgcttttct tttgaccatc attatcacct caatcataat atggcttctt 1649881 ttattgtgtt atatgagaga gcgtaaacag taaaaattac cggtacattt ttctcataag 1649941 tcgaacttat tgtatttaat aaaaacattg atatttactt atgtatgatt ttgttttaat 1650001 atgaaattgt gagaaaattg tgatggaatg taatgttcat ctgagaatga tctgatctga 1650061 agggggattt tggagaatgg caaacgagca aaaaactgca gcaaaagacg ttttccaagc 1650121 gagaaaaacg tttactacaa atgggaaaac atatcattac tactctttaa aagcgttaga 1650181 agattcaggt ataggaaagg tttcgaagct tccttattcc atcaaagttc ttttagaatc 1650241 agtattgcgt caagttgacg gcttcgttat caaaaaagaa cacgtggaaa atttggcaaa 1650301 atggggaact gccgaattaa aggatatcga cgttccgttc aaaccgtctc gtgttatttt 1650361 acaagacttc acaggggttc cggcagtagt agatctggct tcactgcgta aagcaatggc 1650421 agctgtcggc ggagatcctg ataaaatcaa ccctgaaatt cctgttgatc tcgttatcga 1650481 tcactctgta caggtagata aagcgggtac agaagatgca ttagcagtaa atatggactt 1650541 ggaattcgaa agaaatgcag agcgctacaa atttttaagc tgggcaaaga aagcgtttaa 1650601 caattatcag gcagtaccgc ctgcaacagg tattgtgcac caggtcaacc ttgagttctt 1650661 ggcaagtgtt gtccatgcca ttgaagaaga cggcgagctt gtaacgtatc ctgatacgct 1650721 tgtcggaaca gactcacaca caacaatgat taacggtatc ggtgttctcg gctggggtgt 1650781 cggtggaatt gaagctgaag cgggaatgct tggacagcct tcttacttcc cagttccaga 1650841 ggtaatcggc gcgaaacttg tcggcaagct tccaaacgga acaacagcta ctgacttggc 1650901 gttaaaagta acacaagtgc tgcgtgaaaa aggcgttgtc ggtaaatttg ttgaattctt 1650961 cggaccggga attgctgaac tgccgcttgc agatcgcgca acaattgcga atatggctcc 1651021 ggaatacggt gctacatgcg gattcttccc agtagatgaa gaagcgctta actacctgcg 1651081 cctgactggc cgtgatcctg aacatattga tgttgttgaa gcatactgca gaagcaatgg 1651141 cttgttctac actccagatg cggaagaccc tcaatttact gatgtggttg aaattgacct 1651201 gtctcaaatt gaagcaaact tatcgggtcc aaagcgtcct caggatttga tcccgctatc 1651261 tgctatgcag gaaacgttta aaaagcaatt agtcagccct gcaggtaacc aaggattcgg 1651321 tttaaatgct gaggaagaaa ataaagaaat taagtttaaa ctccttaacg gcgaagaaac 1651381 agttatgaaa acgggtgcga tcgccattgc tgcgattaca agctgtacaa atacatcaaa 1651441 cccatacgtg ctgatcggcg ccggactggt agcgaaaaaa gcggttgagt tagggcttaa 1651501 ggtgcctaat tacgtgaaaa cgtcacttgc accgggttct aaagttgtta caggatatct 1651561 tgtgaattca ggccttcttc catacatgaa agagcttggc tttaacctcg ttgggtacgg 1651621 ctgtacaaca tgtatcggga actcaggtcc gctttcaccg gaaatcgaag aagcggttgc 1651681 gaaaaatgat cttctgatta cgtctgtcct ttccggaaac cgtaactttg aaggacgtat 1651741 tcacccgctt gttaaaggca actatcttgc ttcaccgccg cttgttgtgg catatgcgct 1651801 ggctggaacg gtaaacatta acttaaaaac cgatccaatc ggtgtgggca aggatggtca 1651861 aaacgtatac tttaatgata tttggccgtc aatggacgaa atcaatgcac ttgttaagca 1651921 aactgttacg ccagagctat tccgcaaaga gtatgaaaca gtatttgatg acaacaagcg 1651981 ctggaacgaa attgaaacaa cagatgaagc tttatataaa tgggataacg attcaactta 1652041 catccaaaac ccaccattct ttgaagagat gtctgttgag ccaggcaagg ttgagccatt 1652101 aaaaggactg cgtgttgtcg gtaaattcgg cgattcagtc acaactgacc atatttctcc 1652161 tgcgggggca atcggaaaag atacgcctgc cggaaagtat ttgcaagaaa aaggtgtttc 1652221 acctcgtgac tttaactcct acggctcccg ccgtggaaac catgaagtca tgatgagagg 1652281 aacatttgcc aacattcgca tcaaaaacca aatcgcaccg ggtacagaag gcggatttac 1652341 gacgtactgg ccgactggtg aagtaacatc catctatgat gcatgcatga aatacaaaga 1652401 agataaaacc ggtcttgtcg tattagcagg aaaagactat ggtatgggat cttcacgtga 1652461 ctgggctgca aaaggaacaa accttctcgg catcagaacg gtcattgcag agagcttcga 1652521 aagaattcac agaagcaatc ttgtattcat gggtgtgctg ccgcttcagt ttaaacaagg 1652581 tgaaaatgcg gatacactcg gcttaacggg taaagaagtc atcgaggtag atgttgatga 1652641 aacagttcgt cctcgtgacc ttgtgactgt aagagcaatc aatgaagacg gcaatgtaac 1652701 aacttttgaa gcagtcgtcc gctttgatag tgaagttgaa attgattact accgccatgg 1652761 cggcatcctt caaatggtgc ttcgtgaaaa aatgaagcag tcctgatgaa tcaataggaa 1652821 gagaaggcat ttcgctttct cttcttttta tgacacaatg tgctgcggag gtggcatatg 1652881 ctgaaaaaat ggctcgcagg gatcctgctt atcatgctag tcggttatac gggatggaat 1652941 ttatatcaaa catacagcaa aaaagaagtc ggaattcaag aggggcaaca agcacctgat 1653001 ttttctttga aaacgctatc aggagagaaa agctctttac aggatgcaaa aggcaaaaaa 1653061 gtgctgctca atttttgggc aacttggtgt aagccgtgcc gtcaggaaat gcctgcgatg 1653121 gaaaagctgc aaaaagagta cgccgacaaa cttgcggttg ttgcggtaaa tttcacttca 1653181 gctgagaaaa gtgagaaaca ggtccgagcg tttgctgata cttatgactt aacgttcccc 1653241 attctgattg ataaaaaagg gatcaatgct gactataacg tgatgtcata tccaacgaca 1653301 tatatcttag atgaaaaagg tgttatccaa gacatacatg ttggcaccat gacaaaaaaa 1653361 gaaatggaac aaaaactgga tcttgattag attcagtttt ttttatactc aaatatgctt 1653421 acaagttttc agaattggaa aaaataaaag aatatgcgga ggtgagaagc gtgaagaaga 1653481 tgagaaaacg ttcttttcat gagctcgtca tggaaaacaa aaaagagctg atgaccaata 1653541 cagagtattt aaatcagctt gaggaaaagc ttgaacagcg atttaagcaa aaataacctt 1653601 taatttgtat tcatgtttac ccctcctttt gagaaaccta tctgttgagg agggataaac 1653661 atgggaaaca acaagaaaaa cggtcagcct caatatgctc caagccactt gggtacaaag 1653721 cctgtaaaat ataaagccaa taaaggggaa aaaatgcatg atacttcagg acagcggccg 1653781 attatcatgc agacaaaagg cgagtagcga aaattcgagt ttatttctag gaggtacatc 1653841 cgaatgacaa agaaccaaaa tcaatatcag cagcctaatc ctgatgatcg ttctgacaat 1653901 gtggaaaaat tgcaggatat ggttcaaaat acaattgaaa atatagaaga agcagaagca 1653961 tcaatggagt ttgcttcagg agaagataaa cagcgtatca aagaaaaaaa tgcaaggcgc 1654021 gaacagagca ttgaagcgtt tcgtaatgaa atacaggacg aatctgcagc gagacaaaac 1654081 ggataccgtt cttaaaaaac cagggaaacc tggttttttt ctttctgatt tgattatggt 1654141 aaaatggggc taaattgacg ttaagggagc agagtaatct tgcatgtatc aaaaaaagaa 1654201 atagaagtgc gttatgcaga aacagatcaa atggggattg tctatcacgc aaattatctt 1654261 gtgtggatgg aggtcggcag aacggccttg attaaggact taggcttttt atatagtgat 1654321 atggaaaaaa aaggcgttct gtccccagtc gttgatatca atatttccta taaaaagccg 1654381 cttcattacg gagaaaccgc ggttgtacat acatggatag aggactataa cggatttaaa 1654441 accgtctatg gttaccacat ttataatccg gccggtgagc tttccatcaa agccacctca 1654501 tctcatattt gtgtggataa agaaagcttt aagccaattc aattccgcaa agcttttcct 1654561 gattggcaca cagcatatga aaaggccaaa aaatagggaa gtgaacggga tatggcgttt 1654621 ggtgtgaaac gggaggaact taaccggtgg aaacaagcag tgaaaagagg agaaatcgca 1654681 tttttaacac attactggct ggatgaccga tttccagaag caaagaccgt gacaaaagcc 1654741 ggctgtgcag acattgataa gctggttcag tggggagcgg cgtacgggtt aaaaaaagaa 1654801 tggatccata agaaaagtga atttccccac tttgatctgc tgggggaaac acaaaaatat 1654861 attttggaac aagaaaacct aaccgatcat cttatacgat ttcatttgta aaaaaagaac 1654921 gcacatgaag tgcgttcttt tttattggta ttcaaaaacc ggttcatcag cgtcttctga 1654981 atagctgacg agaaggtcgt ggttatcaaa gtaccataaa tcactttctt caataaagaa 1655041 ggtaatgcca tcagcttctg cagtgactcc agcctcttgt ggggcatctt tcgctacacc 1655101 gagagaaaaa cccttttgaa cgttgctgca gcctccatag cggacgaaaa agcgaacctg 1655161 gtctccgctt tccaaatcga gttcttcttt ataccagttc aatgcgtctt cgttaattgt 1655221 catattcata acagaacacc cctttgttct tcatttgaat tttctctatt ataaacgtat 1655281 taggctattc tgtgtcaaaa gagaagtttt ttaagcttat aaccatttta ctttaggttc 1655341 tgttttattg ataattcgtt taatgttcgc tcggtgtctg tatatcacaa aaatagtgag 1655401 cagggtaacg acaatcaata aatacgtatc atggacaaag aaactatata taacagtata 1655461 gatccctgtt aacatcgatg agagagaaac aaatttagtc aagtataaaa agatgaagaa 1655521 taccgcaacc atcgtgataa ataacagggg tgcgtaaaat agcaaaacgc ctcctgatgt 1655581 cgccacggct ttaccgcctt taaatttggc gaagatggga aacacgtggc ctaaaaccgc 1655641 aaagactcct gcaagaagcg ggtgaatatc aacatgcatg agaaaaggca atgcagttgc 1655701 cagtgtccct ttcaaaatat ctccggctat gacgaccgaa ccagctttta cacccaatgt 1655761 acggaatgca ttggtagcgc ctaagttgcc gcttccgtgc tcccgaatat caattccttt 1655821 ggcaagcttg cccacaatta agccagatgg aatgctgcct atcaagtagg ccaaaataat 1655881 caataaagca attaacatct acatttctcc tttttcaaat tcccttcttt ttattttaac 1655941 atgagatgtc atgatctgat gataagtttt tttgtaaagt ttgcttacaa atcaaatcaa 1656001 acatgcatca tattttgatt tctcctgttt tgatcgtgta aaataagtga aaaaggagtg 1656061 acacacgatg caaaaccctt ctaaagcgga aattaaagag attcttcaaa gaagcaaacg 1656121 tatagcggta gtagggcttt cagaccgtcc ggatagaacg tcacatatgg tttcaaaagc 1656181 aatgcaggac gcgggttatg aaattatccc tgtgaaccct acaattgatg aggcgctagg 1656241 tgtcaaagcc gtttcatctt taaaagagat agacggtccg attgacatcg taaatgtatt 1656301 ccggcgctca gaacagcttc ctggagtggc ggaagagttt ttagagacag atgcgccagt 1656361 attttgggca cagcaagggc tagttaatga ggaagcatac cagatgctaa aagaaaaagg 1656421 cagaacggtt atcatggatc tgtgcataaa agtggcacac gctgtaacaa aataggtgca 1656481 gaactgcaaa aatccttgta aattcaagga tttttgcttt ttaattttaa gatattgttt 1656541 gcgtattacg gtgaaacaga tacaataaag cttgaacagc tttttttgaa taccttgtcc 1656601 agctgggttt cggccgttcg atttgcgaag gtctgctgct ttatatataa taaacaaaca 1656661 tacgttctca tagtgtaaaa acagcactag ccgatgtttt gagaagaact gattcgttag 1656721 ctctatgttg cgattgcaaa catattggtt ataatgagga gtccaaggca gtactggctc 1656781 gaggcgaggt ttataaaaaa tatcttatat acaaatgatg tgtaacactg aaaagagaaa 1656841 gacaatgtta gtttttgaaa ggggtttgta cgtttggcta gaaaacagca atttgattac 1656901 aacgaagatg ccatacaggt gctcgaaggc cttgaggctg tcaggaaaag gccgggtatg 1656961 tatattggct ctactgacgc gcggggtttg caccacttgg tttatgaaat tgtagataac 1657021 tctgtcgacg aggtgcttgc cggccatgga gatcacataa tcgtcaaaat acataaagac 1657081 aatagtattt ctgtacagga tagaggccgc ggcatgccga ccggaatgca taagctcggc 1657141 aaaccaaccc ctgaagtgat tttaacggtg cttcatgccg gagggaaatt cggccaaggc 1657201 ggctataaga caagcggcgg gctccacgga gttggtgcat cagtcgtgaa tgctttatct 1657261 gaatggctga cggttaccat tgagcgggac ggttttgtct atcagcagcg atttgaaaat 1657321 ggaggaaaac cggttacatc tctcgaaaag atcggcaaaa caaaaaagac gggaactctt 1657381 acacacttta agccagatcc aacgatgttc agcacaacca cttataattt tgaaacgctc 1657441 tctgagcgct taagagagtc tgcgtttttg ttaaaaggac tgaaaattga gctgattgat 1657501 gaacgcaatg accagcgtga ggtcttttat tatgaaaacg gcatagaagc gtttgttgct 1657561 tacttaaatg aagaaaaaga cgtcttgtct gaagtggtct cgtttgaggg tgagcatcat 1657621 tctatagaag tggactttgc gttccagttt aacgatggtt attctgaaaa tattttgtcg 1657681 tttgtcaaca atgtcagaac aaaagacggc gggacgcatg agtcaggtgc aaaaactgcg 1657741 atgacgcgtg cttttaatga atatgcgcga aaagtggctt tgctgaaaga aaaggataag 1657801 aaccttgaag gcaccgatat aagggaaggg ctttcagcca ttatttctgt ccgcattcct 1657861 gaggagcttc ttcaatttga gggacaaaca aaaggaaagc tcggtaccag tgaagcaaga 1657921 tcagcggtgg atgcgattgt ttcagagcag cttgcttact ttttagagga aaatcgggac 1657981 accgcaacgc ttcttgtcaa aaaagcaatc aaggcgagcc aggcgcgcga agcggcacgc 1658041 aaagcccgtg aagaagcaag aagcggcaaa aaacgaaaaa aatcagaagc gactttaagc 1658101 ggaaagctga cgcctgcggg ttcaagaaac ccggcaaaaa atgaattgta tctcgttgag 1658161 ggagattcag caggcgggtc agccaagcag ggacgagacc gcagattcca ggcggttctg 1658221 cctttacgcg gtaaagtcat taatacagaa aaagctaagc ttgctgatat ctttaaaaat 1658281 gaagagatca atacgatcat tcatgcgatc ggcgggggag tcggggcaga tttctcaatc 1658341 gatgacatca actacgacaa aatcatcatt atgaccgatg ccgatactga cggcgcccat 1658401 attcaagtgc tgcttcttac ctttttctat cgctatatga aaccgctcat tgagcatggc 1658461 aaggtgttca ttgcgctgcc acctttatat aaggtcagta aaggaagcgg gaaaaaggaa 1658521 atcattgaat atgcatggtc tgatgaagag atgggggatg tcctgaaaaa agtcggcaaa 1658581 ggctatacca ttcaacgata taagggtctt ggagagatga acgcagacca gctgtgggaa 1658641 acgacgatga atccggagtc ccgcacactt gttagggtca aaattgacga tgcggcacgt 1658701 gtagagagac gtgtgacgac gttaatggga gacaaagtag agccgcgcag aaagtggatt 1658761 gagaaaaacg tcgctttcgg cttagatgaa gaaagcaata ttttagaaaa tgaaaactta 1658821 tcggtcgctg aggaggttta atgattgtca cagccagaat tatttcatga tttaccatta 1658881 gaagaggtga tcggcgaccg ttttggacgc tacagtaaat atattattca agacagggcg 1658941 ctgcccgatg cgagagacgg attaaagccg gtacagcgca gaattctgta tgcaatgcat 1659001 acagatggaa acacgtttga taaaaacttc agaaaagcgg ccaaaacggt cggtaacgtc 1659061 atcggtaact atcatccgca cggtgacagc tcggtttatg aagcaatggt gcggatgagc 1659121 caggattgga aagttcgtaa tgtgttaatc gaaatgcatg gaaacaatgg aagcatcgac 1659181 ggagatcccc cggcagccat gcgttataca gaggcacgat tatctccgat agcatctgag 1659241 cttcttcggg atattgacaa aaacacggtt gaatttgtgc cgaacttcga tgatacaagc 1659301 aaggagcctg tcgtactccc ggcgatgttt cctaacctat tggtcaacgg atctaccggg 1659361 atttcagcag gatacgcgac cgacattccc cctcatcatc tgggagaagt cattgatgct 1659421 gtcattaagc gtattcaaat gccttcttgc tctgttgacg aactcatgga agttattaaa 1659481 gggcctgatt ttccgacagg cggtattatt cagggcgttg acgggataag aaaagcttac 1659541 gaaaccggaa aaggaaaaat cattatccgc ggaaaggctg aaattgaaac aatcagaggc 1659601 ggacgagaac aaattgtcat tactgaaatt ccatttgaag taaataaagc aaaccttgta 1659661 aaaaaaatgg acgagttccg tattgataaa aaggttgaag gcatctcaga ggttcgtgat 1659721 gaaacggatc gaacagggct gagagtggtc attgaactga aaaaagaagc tgatgccaaa 1659781 ggcattttga atttcttata taaaaatact gatttgcaga tcacatataa cttcaatatg 1659841 gtggctatcc ataaccgccg tccgatgctg atgagcctgc cgtctatttt ggatgcatat 1659901 atcggacacc aaaaggaagt tgtcacaaac cggtccgttt acgagcttca aaaagcaaaa 1659961 gacagacatc atatcgtaga agggctcatg aaagctttgt ctattttgga tgaagtgatt 1660021 gcaacaatcc gttcttctag cgataaacgt gacgctaaaa acaatttgat cgcgaaatat 1660081 gaatttacag agcctcaggc tgaagccatc gtgtcattgc agctatatcg tttaaccaat 1660141 accgatatca cagcgcttaa ggaagaggca gaagagctcg gtaaaaaaat tgaagagctc 1660201 gaatctattc tgagcaatga taaaaaactg ctaaaagtga ttacaaacag cttaaaagca 1660261 ctgaaaaaga aatatgcaga tacgagacgc tccgtgattg aagaaaaaat tgaagaaatt 1660321 aaaatcaatc tcgaagtcat ggttgcatct gaggatgtat atgtaaccgt tacgaaggat 1660381 ggttacctaa aacggacgag ccagcgctca tttgccgctt ccaacggtca ggacttcgga 1660441 atgaaagata cggacaggat gctgcatcag tttgaaatga atacgacaga cgtgctgctg 1660501 ctctttacga acaaaggaag ctacatctat tgtcctgttc accagctgcc tgatatcaga 1660561 tggaaggaca tgggccagca tttttcaaat ctaatcacta ttgaccgtga tgaaacgatt 1660621 gtaaaggcta taccgataaa agaatttgat ccgtcggcat atcttctatt ctttacgaaa 1660681 aacggtatgg tgaaaaagac agagctcact cattataaag cacagcgtta ttctaaggca 1660741 cttgtagcct taaatctgaa gggtgaagat gaactgattg atgtacatgt aacaaatggg 1660801 gaaagccaga tctttatggc cactcactta gggtatggtc tatggtttgg agaagacgaa 1660861 gtgaatgtag ttggcgcgcg tgcggcaggt gtcaaaggga ttaacttaaa agaggatgac 1660921 tttgttgtct ccggtgagat tcttcagcaa tctgattcaa ttgtcttgtt cacacagcgg 1660981 ggagcggtta aacgcatgag tctttctgag ttcgagaaga catcccgtgc aaaacgcggt 1661041 gtcgtaatgc taagggaact gaaaaagaat cctcaccgtg ttgtagcact gttcgcttgc 1661101 ggtcttgaac agcgactaat ggcagaaaca gaaaaaggcg acagaaaaga actgcagaca 1661161 aaagagttgc ggacaaacga cagatacagc aatggctctt tcttttttga tgaagaggaa 1661221 tcaggcaagg ttacagctgt ttggcgcctt catacagaac aataataaaa aacccgctca 1661281 tactatatga gcgggtttcg tttgtttttt atcagctttc atggttggtg aatagatctg 1661341 ttacagcatg aatgacttca atcccctgcc atacaaataa attcagcgct gtgaaagaaa 1661401 ataagcctaa aatcaccatt cttaagataa acaacatgtt taacagcctc ctcatatttt 1661461 cgttacataa tcgggtgatg ttgaacatga agtttgccga aataagacga ttgataaaat 1661521 ttggccagta taaagctttt tttccgctga cgtctgcggg agtatcccgt acttttgctt 1661581 tcagcggtca gcagcagaac agccattgcc cataaagcgg tcagcgtaaa tgcccctgtg 1661641 atggatttct tctcatcatc agcattttgg ccggctttca tctcatgcat ttcctgctgg 1661701 tcggctacgg ctttataatg atggccgata tcaaaggcgt ggggaattga gaacaaatga 1661761 aaactggcaa tcgccaagaa taagatggat gctttcaata tcgttacttt tttcaaatga 1661821 tctccccctc ctttaatatt actgaatatt tttataataa taccccaatc catcctaaaa 1661881 gtaaacctga tttattaaat ttaaaaataa atttaacttt gttaagtata tatctttttg 1661941 cttatttttg aaagagaaaa cttcttttat tagcgtatgt atacccggtt tatggtgtga 1662001 ataaaaacat attttaaatg atatgttgtt taggatttat tactttattt atgtgtaaat 1662061 caaagagaaa ggcaagagaa tgggaagaaa tgattacatt gttaataggg tactcttttt 1662121 ttaaagccag tttgcaagga atgtttttat tcgtaggaaa ataatagaga aggggtcgac 1662181 agagtaacat ctggctatga caatattctt ctcgaaaaaa cttcctaatt cgtcatattg 1662241 tgatataata aaactcgtta tgttaaaaaa tctaacatca aaatcgaatt cgtattgaat 1662301 tgatgaaaac gggaggtaaa tatggagtct tttttcaata gtttgattaa tattccaagt 1662361 gatttcatct ggaaatacct attttatatt ttaatagggc ttggattatt ttttaccata 1662421 cgttttggtt ttatccaatt ccgttatttt attgaaatgt tcagaatagt aggggagaag 1662481 ccggaaggaa ataaaggtgt ttcatctatg caggcattct ttatttcggc cgcatcccga 1662541 gtcggcacag ggaatttgac tggtgtagcc ttagcaattg cgacaggcgg accaggcgct 1662601 gtattttgga tgtgggtagt ggctgcagta ggcatggctt caagctttgt cgaaagtaca 1662661 ttagcacagc tttataaggt aagagacggg gaggatttcc gcggagggcc ggcctactat 1662721 attcaaaagg gtcttggtgc cagatggctt ggcatcgttt ttgcaatctt aattaccgtc 1662781 tcattcggct tgatttttaa cgctgttcaa acaaatacaa ttgctggagc attggatggc 1662841 gcattccatg taaataaaat agttgtagcc atagttctgg cggttttaac tgcgtttatc 1662901 attttcggcg gtttaaaacg tgttgtcgct gtttcacagc taattgtgcc ggttatggca 1662961 ggcatttata ttcttatcgc tttatttgtt gtcatcacga atattacggc tttccctggc 1663021 gttatcgcta caattgttaa aaatgcttta ggttttgaac aagtcgtcgg cggcggaata 1663081 ggcggcatca tcgttatcgg tgcgcaacgc ggactttttt caaacgaagc aggaatgggg 1663141 agcgcaccaa acgcggctgc gacggctcat gtatcccatc cggcaaagca aggctttatt 1663201 caaacattag gcgtattttt cgatacattt atcatatgta cgtccacagc atttattatt 1663261 ttgctgtaca gtgtaacgcc aaaaggcgac ggcatccaag tcacacaggc tgctcttaac 1663321 catcacattg gaggctgggc gccgactttc atcgcagtcg caatgttctt gtttgcattc 1663381 agttcagttg tcggcaacta ttattatggc gagacaaaca ttgaatttat taaaacaagc 1663441 aaaacatggc tgaacattta ccgtatcgct gttattgcta tggttgtgta tggatcttta 1663501 tcaggcttcc aaatcgtttg ggatatggcg gacctcttta tgggtatcat ggcgctgatc 1663561 aacttaattg tgattgcgct gctgtcaaac gttgcttaca aagtgtataa agattacgcg 1663621 aaacagcgta agcaaggact tgatcctgtg tttaaagcga aaaacatccc agggctgaaa 1663681 aacgctgaaa catgggaaga tgagaaacaa gaagcataat ataaatataa aacaaagctg 1663741 cattcaatag ttgaatgcag ctttttcatt attggaaata aatttaattt ttcgactcga 1663801 atgaaaaatg acgtgtaaag tcccaattca gtccagtttt ctttgttcta tatgtgtcat 1663861 gtgtgtctta ttcattggag gtagagcaaa ttgacaggct tttaaacctc cccaaaacaa 1663921 gaaattaggt tgatagacaa tcatgagaaa gatttttaca atgagttcgt gctcataaga 1663981 agtgtagagc caaaatgatg cgaaggagga aaagatcaga tatgaaacgg tcaatctcta 1664041 tttttattac gtgtttattg attacgttat tgacaatggg cggcatgata gcttcgccgg 1664101 catcagcagc agggacaaaa acgccagtag ccaagaatgg ccagcttagc ataaaaggta 1664161 cacagctcgt taaccgagac ggtaaagcgg tacagctgaa ggggatcagt tcacacggat 1664221 tgcaatggta tggagaatat gtcaataaag acagcttaaa atggctgaga gatgattggg 1664281 gtatcaccgt tttccgtgca gcgatgtata cggcagatgg cggttatatt gacaacccgt 1664341 ccgtgaaaaa taaagtaaaa gaagcggttg aagcggcaaa agagcttggg atatatgtca 1664401 tcattgactg gcatatctta aatgacggta atccaaacca aaataaagag aaggcaaaag 1664461 aattcttcaa ggaaatgtca agcctttacg gaaacacgcc aaacgtcatt tatgaaattg 1664521 caaacgaacc aaacggtgat gtgaactgga agcgtgatat taaaccatat gcggaagaag 1664581 tgatttcagt tatccgcaaa aatgatccag acaacatcat cattgtcgga accggtacat 1664641 ggagccagga tgtgaatgat gctgccgatg accagctaaa agatgcaaac gttatgtacg 1664701 cacttcattt ttatgccggc acacacggcc aatttttacg ggataaagca aactatgcac 1664761 tcagcaaagg agcacctatt tttgtgacag agtggggaac aagcgacgcg tctggcaatg 1664821 gcggtgtatt ccttgatcaa tcgagggaat ggctgaaata tctcgacagc aagaccatta 1664881 gctgggtgaa ctggaatctt tctgataagc aggaatcatc ctcagcttta aagccggggg 1664941 catctaaaac aggcggctgg cggttgtcag atttatctgc ttcaggaaca ttcgttagag 1665001 aaaacattct cggcaccaaa gattcgacga aggacattcc tgaaacgcca tcaaaagata 1665061 aacccacaca ggaaaatggt atttctgtac agtacagagc aggggatggg agtatgaaca 1665121 gcaaccaaat ccgtccgcag cttcaaataa aaaataacgg caataccacg gttgatttaa 1665181 aagatgtcac tgcccgttac tggtataaag cgaaaaacaa aggccaaaac tttgactgtg 1665241 actacgcgca gattggatgc ggcaatgtga cacacaagtt tgtgacgttg cataaaccaa 1665301 agcaaggtgc agatacctat ctggaacttg gatttaaaaa cggaacgttg gcaccgggag 1665361 caagcacagg gaatattcag ctccgtcttc acaatgatga ctggagcaat tatgcacaaa 1665421 gcggcgatta ttcctttttc aaatcaaata cgtttaaaac aacgaaaaaa atcacattat 1665481 atgatcaagg aaaactgatt tggggaacag aaccaaatta gttaagcttt tttttggcgg 1665541 acatcagtaa cgatgtccgt ttttatcatc taataggagg tttgcgttgt ggatgaaata 1665601 ctgaaacagt atatggtgct gtataaaaaa atgagtaata tgataaatgg tcccgactat 1665661 ccaggtaagg aaaaagacat ccagcatcaa aaagatcaga tcgaagttta cgaaaaacag 1665721 ctgcagcaag gattttctac agattatgac tatgatgtgt ttgctgattc tgttatcaaa 1665781 tgcgcatatg gcgatatgac gctggaagat ttagaagccg tttattatgg attgacaaca 1665841 ccattttttt gatttgtcat tcagcagtaa aatttcaatt tctgtctcac taacttaagt 1665901 atactttgat attgagacag aaatttattt attttgttta cttcctagaa tatatattat 1665961 gtaaactaga aaagatgaag aataaagctt tgctgttttt atgtacatcc tttcttcttc 1666021 ctgtaattca gcaacaaaat aaaaaagcga tttcccaatc ggaaaatcgc caattcagac 1666081 actctattat ttatgtgtgt ctttgtgctc ttaacgattt acaacaaatg ttgtcacgct 1666141 ttgagctgga agatgagccc aaaaatgatt gcctgataca gtgagattcg ttccaggttg 1666201 tagattgctg ctgctgctcg tgatccatct agatacgttt gaagcagatc cattctgcaa 1666261 aacaaagttt tggttgactc ctgtgttgct tttattgatg gcaacaataa cgaccttgtt 1666321 gtcaccttta taggctgaca cgtaaacgtt cgcattaggg tttttcgttg catcaatcct 1666381 tacatagccg ggacgcacaa actttgagaa atgagccata ttgtagccgc gtttgctgat 1666441 cgtaccatct tctttcatag gtccatatga tcttcggatg taccaccata cataagcttg 1666501 aaagtccccc tctaccatcg cattgtgaat atgctgtgaa acatccaatg cctcaggcca 1666561 tcgatccgcc gagttggtat cactgtttgg atagtatact tccgtcatcc aaaggtcctt 1666621 ccccgctcct ttttgtttga aaagaggata agggaattgg ctgacctggg tgccgtacag 1666681 gtgagttccg agaatatcca tattggcaag agcctgcgga tcgttcaaga tcgggtccga 1666741 caaattcttc aagtattgaa atgactcagg cgcaatgacg cgggcattga tcgagccggc 1666801 gttttctctc ataaagcgaa gtatttcttg cggcgtccac cacgtccact cgtgagcgta 1666861 atcaggctcg ttttggaccg aaatcgcgta aagattcaca ccattattct tcatgaaggt 1666921 aacaaaatcg ttaagatgct gcgcgtatgc tgcgtacttg ttgtatttca gccgtttagc 1666981 cgatgtgtca ccattccgat taaaggtctc aaccatatca cttggaggat tccaaggaga 1667041 agcaaaaacg attgctccgt gtttgaccgc actctttgca gtctccacct ctttatacca 1667101 attatttcga ttttcatcta catgaattct taagattgaa aatcctaact ggttctgtcc 1667161 attgccaaaa gcagtttctc tttgagctgc tgtaagatcc ccagcccaag ccggatgatt 1667221 catccctcca aaaccgcgaa tcacttgttt ctctgcagat acattaactg ttacatcact 1667281 tgctgccaaa acttcagtag cgcctggccc taacatgact gacagcatag tgaaacatac 1667341 taatagtaca caaattgttt tttttatgcg tggaatcatt tattcctctc cttcgtcatg 1667401 tgtcttttac ggtattaaaa aatctgcatg gcatatccat aatggcgggc tgttccggtg 1667461 ctggcccgta cttcacccgc ctcgttttta agcggtccca ttacgagtac tatctttgcg 1667521 taaactgcca gtaatcaaaa ttaaacaagt ttcctgtacc tgttccggta aatacaaaga 1667581 atactttgtg cacaccggtt gccccgctta ccgcagtttc tatttccctc cacgtttgcg 1667641 ctccgcctgt tgaaggcaca ttcagagttc caacaagctt accgtctgca ctgtcgaggc 1667701 gcacttctat tttcccgcct aaagtggatg ctacatttgc tttaaatgac ctggcaccgc 1667761 ccgctccgaa gtctgcattt cctacagcaa tccagtctcc attttgaatg cttgttacat 1667821 gctgattatt tactggcccg ccgggtgctg tggacttctc tgtcaaaatg cgtccattcc 1667881 aagcaaacgt ttcagcttct acccggttat atgggtttaa attggaaatt tgtgttacac 1667941 ctgcataatt tgccgctacc tcttgaatag atccatctgc attatgcacc agcttattaa 1668001 tatggggaga gcggtatcct ttgccggccc cgaacagagc ggaactgaca gtttgcgcat 1668061 ggtacaccac ataccactcg tttttaaaat tgaaaacagc atgatggttg tttccgccac 1668121 ctccgaaaaa tgcacccgga tttttcagga agtgccctct atatgtaaag ggacccatgg 1668181 gacttgaact ggtcatgtag ccgatctcac ccgggggttt atcggccggg tgcgtgccgc 1668241 cgaaattgat gcaataggag taataatatg ttccgttata cttgtgcaat cccgaatctt 1668301 caaacatgaa aggcgcatca attgtagatg cacttccaac aacactcgtc atatcaggcc 1668361 ccaattttat gactctagcc gttttaggat tggcccattg tccctgcgtt ggatttgaaa 1668421 cgccaggaac gcctccgccg gcatacaggt aaccggttcc gtcgtcatct acaaatactg 1668481 ccggatcaaa aagccataca acaccagaca ttcctggcgt acttggcgtt acgagcggtt 1668541 ttccgattgg gtcggtccat ggaccaatcg ggctgtctgc ggtgagaacc ccgatacctc 1668601 cgccgctgtt tgcgaaataa aggaagaatt tatccttgcc attaattttt ttaactgcga 1668661 ttgacggtgc ccatgacgca cctgcccatt ttgcaattcc acggcctcca ttagctccat 1668721 tggcacctgc taccggaatg gctccgtggt ctgtccagtt caccatatcc gctgaagata 1668781 tgacgaatac tctattcaaa ttggcaaatg aattatcttt aattgttccg ttgctattat 1668841 attcatagtc atcacttgac atatagatgt agactcttcc gttataggtc agcgcaaccg 1668901 gatccgctcc caaatgatgg tcgataagcg gatttgaatt ccctatatgt tttgcaattg 1668961 tagtactagt ggcagcatac gcagacttcc cagataagca gctcaataat aaaactagaa 1669021 tccataaaca tacgctacac tttttcctca tcacttcaca tcctcctttt tccttaaaat 1669081 gggggatttt cttttggaat ttgataacaa caggtcacga agattgcacg cataaagtag 1669141 ccggaagctg tttagcaatg ttcccagttg ttctgaaagc tcatcttcat gtgtctccat 1669201 tctctctttt cttcgaggag atcgcaccac tccttcaaaa ttgttcaaaa aaacttcccc 1669261 attcctagcg accattgtcc agaaaataaa aagacaggat tgttcatggc ctcccactaa 1669321 tcacattgaa cggagattac atcattatcc aagatatccc tttatctaac atcctacatc 1669381 attaaaaaaa ttgtgtatag aaacttttgg aggagttagt gttcgattct acaaaggaac 1669441 tggatacatt tattcattga taagatgggg ctaacactcc gtttatattt gtatgttttc 1669501 agacacaaaa aacagccgtt caatgcggct gtttttttca agagtataag actattgagc 1669561 ggtatacccg ctttttcatg ttttgttcat attttattaa ttgtttattc aacactgtcc 1669621 gctatagtaa tccatatcaa caaatatgac tgccactcgc atcttttatg aagggaggtt 1669681 cgttacgctg aaagaaaaaa taaagacatt aggccgtttt tgcaccgtag gcgtcggcaa 1669741 tacgctgata gattttggtg tcttctttct tcttaccgct tgtcatgtct cttatctgcc 1669801 ggcgcagatc tgctcctata ctgcaggtat cgtcaacagc tatgtgtgga accggaattg 1669861 gacgttttgt gtgaaacgta aggctgacgg gaaagagatc gtgcgttttc tcatgattaa 1669921 tattgccgcg tcagggatca cctttttgct gctttatttg tttcaaaatt gcggctgctc 1669981 gcttttggtg agtaagctcg ccgccactat cggcggaatg atgatgaatt ttatcggaaa 1670041 ccgaatctgg gtatttggag attcgctgaa aaacatacag gatcaggagt gaagatgaat 1670101 gagaaaaaaa gtgagaaaag cggttatacc cgcagcgggt ttaggaacga gatttctgcc 1670161 ggcgacaaag gcgcagccta aagaaatgct tccaatcgtc gacaaaccag caatccaata 1670221 tattgtagaa gaggccgcag agtcaggaat tgaagatata ctgattatta cagggagaaa 1670281 caaacgctcg attgaagatc attttgatcg gtcggcggaa ttggaattca atctccggga 1670341 aaaaggcaag acggagacac ttaaggaaat gcagcagatt gccgatttgg ccaacattca 1670401 ttacatccgc cagaaagaac cgctcggatt aggccatgcg gtgctgtgtg cggagcattt 1670461 tatcggagat gagccttttg ctgttctctt aggtgatgat attatggtgt ctgaaacacc 1670521 ggctcttcgg caattaatgg atgtatatga cgtttatggc acagaggttg tcggtgtaca 1670581 gtcagttctc cctgaggatg tcagcaaata tggtattata aatacatcag ggtctcaagg 1670641 gcatgtatat gaagtgaacg atttagtgga aaagccttct cctgaagaag caccttcgga 1670701 aatcgcagta atgggacgtt atgtgctgaa ttcttcgatc ttctccgttt tgaagacaat 1670761 tggcagaggc gcgggcaacg aaattcagct gacagatgcg cttcgtgagg tttgccgtaa 1670821 ggagccgatc catgcccggc tgctggaagg aaatcgatat gacattggcg ataagctggg 1670881 ctgttttaaa gcgagcaccg aaatcggctt aatgcgtccc gaaatgagat ctcagctttt 1670941 ggcctattta gaagatgtga tcaaacggga aacgaaagaa atgctgcggt aaaaaaattg 1671001 taaccatctt gctcgtcaat cagtcatata atagtgaaaa agattaggac aggttgtgaa 1671061 gaatgtgggc agtttgataa gcgaaatttt aacatggctg acgaacatgg gatatgcggg 1671121 tattgcgatt gggttaatga ttgaaatcat tccgagtgag attgtattag cttatggcgg 1671181 ctatatggta tcggagggca cgattggatt tattggcgca attattgcgg gtgttatcgg 1671241 gggcaccatt gcccagatct ttatttactg gatcggtcgc tatggcggca ggccatttct 1671301 ggacaaatac gggaagtatt tattgattaa aaagcatcat atcgatatgt cggaaaactg 1671361 gtttcagaaa tacggcgccg gagttgtctt ctcggctcgt tttataccgg ttgtcagaca 1671421 tgccatatcc attccggcag gtattgccag aatgcctttt ctcaaatttg tggtactgac 1671481 tgtgcttgct atcattccat ggtctatcct gtttgtttat ttaggcatac agctaggaag 1671541 ccagtgggat gatgttgaga atatagcagg cacttataca acaccgatta tgatattggc 1671601 tgttgtcgtg atagcccttt attttgtgat taagaaacgt acagccatat ttaaacgata 1671661 gctagcggat atgcataggg gtgactgacg ctcccctatg catatttttt tacttgcgat 1671721 gttgatttgc cagcttcaga ttctccgcta aaaatgcgac aaacacttca tcccgcacga 1671781 gcgatgcggc ataatttctc ttaataaacc attctgcctc ttcaaacgct gcgaatgttt 1671841 cgtcttgggt ttctccgtta atttgaatat tccattcgtt gtctaaaggg aaaagaaaaa 1671901 atctcatttg tgcgcgattt tcatataatg atccattcgc agatcccttt agattataga 1671961 tgttacggaa ggcatccggc cgtacaggat caatacggaa agcttcagct acaaacaact 1672021 cgtatacttc atcggttatt gaacagccgg acgcttttgc atgccctccg ccgccatatc 1672081 ggccggcgat ttctgacaca tcgatgtaat catgaatggt gcggagactg actcgttttg 1672141 accccatgct caaaatcgca atgtaatcga ggtgcgggtt atctttccct agcctgttcc 1672201 ccagctctga atggtacgat tcagcgtgaa cgatgcctac acagtgttcg tgaacaaagg 1672261 tttgtaccat ttcccttttc tttctgcgga ggtagcgctc gattttttcg tcttctaaat 1672321 caagcagttt ttcttcaaaa tcatcgaaga aaaattcgtc atgcgtggaa aggcgctgga 1672381 tcatttttgc ttcaaattca tcgattgaca gcaaaaagaa aagatcatta agccgcttcg 1672441 cctgtttttg atcgtaccgc tcccactccc atgtatcgta ttggcggacg agctctgtga 1672501 attgatctaa ggcgtttgtc ggtttcatga agccattttc aatgagatag ccatataaaa 1672561 gcgatgtcgc ggatgtgagc cttccatcat cgtattccac ctggacaaat ccccattcat 1672621 gctcattcaa atgaagggct gttttatgat ggtcaatgag cttcactttg ccccctgcat 1672681 gaacatactc attcaatctc tcttcgtttt cttcattgac ggcgagatcg gtgatgaata 1672741 acgcgtcctg tctgttgctc tccttcgctt tttctaaaaa gtactgcacc tgtgcgttta 1672801 agccgttgac agagttatac cggatctcta cgtcttttcc gaacgccaat tttgctacga 1672861 ttccgcatcc tactccgtcc aagtcgttat gtgaatataa atgatacata atgtaggccc 1672921 ctttttatga taaactgaca attgccgcta gaggtgcggc agcctttatt tactattcta 1672981 aaaaaccaag cgttttatgc aatggtaatt agttgacata atgttgttat tgtaaatata 1673041 taaaggagcg ctttttttgc gctcctaagt tcttgctttt acaccggata aaccggatgc 1673101 tttcgattgg taaatgtcat ttcctttgtc atgtatgcct tgagccgttt ggccagctca 1673161 tcacgcagcg aattggctgg gataacagca tcaatgatca tttctgaagc cagacggtag 1673221 atattgatgt cctctttgta ttcctcccgt ttgctgctga taaatgcggc tctctcttct 1673281 tctggcagct cggcgatttt tttagcgtag acagcgttta cagcggcctc agggcccatg 1673341 acggcgattt gggcggttgg gagcgctaga cagcaatccg gttcaaatgc cggccctgcc 1673401 attgcataca accccgcccc gtaagctttt cggacaatga cagagagttt tggaacagtt 1673461 gcctccgaca tcgcagaaat cattttcgct ccgtgtctga taatcccagc ctgttctact 1673521 tttgtgccaa tcataaaacc ggggatatcg gctaagaaca gcaatgggat atgaaaagcg 1673581 tcacataagg taataaactt agccgctttg tctgctgaat cgtggaataa gacgcctcct 1673641 tttaccttcg gctggtttgc aacaatgccg acaggctgtc cgtggattcg tgcgaggccc 1673701 gtcaataatt ccggtgcaaa taaggctttg atctcaaaaa atgagtcttc atctatgacc 1673761 cgctcaatga gctcatgcat atcaaaaggt gcgttttgat tttgcggaat gacgtcggca 1673821 agcggagttt cgaagtgttt tggcgggcgt ttctcatgaa tgggcgcttt ttcttgaaaa 1673881 tttgccggaa agtaagacaa ataagcccgc accagctgta tggcttcttc ttcagtttct 1673941 gcaagaatat ctccgcagcc ggagattgag caatgcatac gggcgccacc catttcttcg 1674001 agagacactt tttctccaat aaccatttcc gccatccttg gcgaacctaa atacatggag 1674061 gcgttaccgt ctaccataac gacgatatca cagaaggccg gaatataagc gcctcctgcc 1674121 gcagatggtc cgaaaagcag acagatttgc ggaatgcgtc ccgataattt gacttgattg 1674181 taaaaaattc ttcctgcacc gcgtctccct ggaaagacat tgatttggtc ggtaattcgg 1674241 gcgcctgccg aatcgactaa ataaatgagc ggacagttta atttttcggc gatttcttga 1674301 attctgatga ttttttcaac tgtttttgct ccccatgacc ccgctttcac tgttgaatca 1674361 ttcgccatga cgcaaacggt ttggccgccg attttgccga tagcggttac aactccgtca 1674421 gcgggaagcc cgtctgacat acattccgca aaaaaagcgt cttctagctc aatgtcatcg 1674481 tcaaagagaa gggaaagccg ctctctgaca aagagcttgc ctttttcccg attgctttga 1674541 tgatactttt ccgctccgcc ttttcgaatc cgttcagccc gttctgttcg ttccttttca 1674601 taatccatca gcattgcctc ccttttatat tcccttgtat acggcccgtc ttttttcttg 1674661 aaaggcctga agcccttctc tcctgtcttt tgtcgggatg gtttgttcat acgctttttg 1674721 ttcaatcgca aggcctgtag caagatctgt ctccaatcct ttattgattg caaatttagc 1674781 ctgacggaca gcgatcggtc cgttggcaga aatggctgcg gccagttcct ctgcttttgg 1674841 cataaggtca caaggagccg tgacatgctc tacaaggccg atttcttttg cttcgtgtgc 1674901 ggtcacgcgt ctgcctgtat aaatgaattc ttttgctttt cctctgccaa tcagccgggg 1674961 cagcctttgg gtccctccag cgcccgggat aatagctaac cctgtttccg gaagtcccag 1675021 cacagctgct tcagttgcga ttcgaaggtc gcatgccaat gccaattcta gtccgccgcc 1675081 taatgcgctt ccatttatcg cagctatgac cggctgcggc aaggcatcaa gtaaagccgc 1675141 cgttctttga atgagagata cactttccag aacctgatct tctttcagtt ttatccgttc 1675201 cttcaggtct gcccctgcac aaaacgcttt ttcaccggtg cctgtgagga tgacgcaacg 1675261 gatgtttgag ttaaattcaa tttcctggat aatcatttgc aggtttctaa gcatttccgc 1675321 tgaaagagca tttgctgcct gaggcctgtt taaggtgatc aacgccatat gttcattttt 1675381 aacagtaaaa agaatagaat ctcccattgt atgcgtcctc ccttttatca agatgattta 1675441 aacacctgta aatttctgct cggcagcggt ttgcccattt tttcttcaat ccatttggcc 1675501 gcagatagca gtttttctag ctttacattt gttttgatat ccatctgttc aagcatgtac 1675561 acgatatcct cagttgcggc gtttcctgat gaacctggcg catatgggca tcccccaagc 1675621 ccgcctgccg agccgtcgaa caccgtgatg cccatttgga gtgctgtgac catgttggcc 1675681 agagcggttc ctctcgtatc atgaaaatgc agggcaattt gattagccgg gaatcgtgcc 1675741 aaaagagctt caagtacagt ttccacttgg gcgggattag ctgctccaat cgtatctcca 1675801 agcgacagtt cagaaatccc aaattcaaat agagcttctg aaaggcgaat gacttgttca 1675861 atggggacat ctttttcgta cggacagccg aaaacagtcg agaggtaggc tcttgttgtg 1675921 aggtttgctt tttgtgcgtc gttgtttact tgtttgagta tatggaggga ttcagaagtg 1675981 gatttattga tgttttttct gttgtgcgtc tcgctggcgg acataaaaac gcaagcctcg 1676041 ttaatgcctc cttcaagtgc attctccagt cctctttgat tcgggacaag tgccgcgtac 1676101 gttacccctt tttctcggtc gatgcctttt gctacatcga tagcatctcg aagcgccgga 1676161 atccatttcg ggtgaacgaa ggatgtgatt tcaatatacg acagccctgt ccgggaaagc 1676221 tggttgatcc aggttatttt atcctctgtt gcgatccaaa cgggctcgtt ttgtaagcca 1676281 tcacgcgggc cgacttcttt gattgtcact tttttaggat atggcatggt cttcctccaa 1676341 attattgagt ggaattgctc agttcgagca gtacgtctcc ttcatttaca aagtcgcctt 1676401 cctttttttt gacttctttt acgattccgc ttctatctgc aacgatcggg atttccattt 1676461 tcatcgattc caaaatggct acctcctggc ccttttcgat ttggtcgccg gctttgacgt 1676521 ggactttcca caggtttcct gccatttgta tgctaaccgt catgacaact gcctccttta 1676581 taggtgctgt ttcaaaaagt cagtcgtgac atccccttct ttaaatgcct ttgttgccgc 1676641 agcctgtatg aggagcggaa ggtttgtttt gattccctct acacgatagt cgcgaagcgc 1676701 tgtctctagt ttttcaattg cttctgttct ggtttggcct ttgacaatca tcttagcgat 1676761 catcgggtca taaaaagggg taacggtgct gtcttttgct accgcacatt cgtgtctgac 1676821 tcctttttgg tcaggaagtg aaaacgcagt gatcgtacct ggtgacggga agaaggtctt 1676881 gggatcttcc gcgtatattc gaacctctat cgcatgcccg ttccgttgga tgtctttttg 1676941 ggagaatgtg agtgtatggc ccgcagcaat ccgcagctgc tgctcaacta agtccaggcc 1677001 tgttatttct tcagtcacgg ggtgttcaac ttgcagtctc gtattcattt cgaggaaata 1677061 aaaattttgt ttctggtcaa ctataaattc gatggtgcct gcgttcgtat agccgattgc 1677121 cttcgctgct tttaccgctg tttgaccgat cttcattctt agttcatcgt ctacaaatgg 1677181 agacggtgct tcttcaatga ctttttggtg gcgcctctga acagagcaat cacgttcaaa 1677241 cagatgtact gtatggccgt gttgatcggc caaaagctga acctcgatgt ggcgcgcatg 1677301 ttcaataact ttttctatat acatagaccc gtcaccgaaa aaatctgctg cgcgcttttt 1677361 gtttccctcg tacgcttttt ttaatgcttc ttcattttca acacgctgca ttccgatgcc 1677421 gcctccgccc gctgaagctt tcagcatgac aggatagccg atttgacttg cggtgcggca 1677481 ggctgcctct atatctccga gggattcaga aacgcccggc accacaggga cacctgcagc 1677541 ctccattgct tttcgcgctt caattttgct gcccatcttt gcgatgatat caggggaagg 1677601 tccgataaac acgatgtttt cttgcttgca gcgttcagcg aaccggctgt tttctgataa 1677661 caatccatat cccgggtgga tcgcgtcggc ttttgctttt ttcgccgtct ttatgattct 1677721 ctctatattt aaataacttt cactgactct cgattccccg atcaaatatg cctctgtagc 1677781 ggcttttgta tggggcgcgt ccttgtctgc ttctgaataa acagcgaccg ttttaatgcc 1677841 gagacggctg catgttcgga taattctcat tgcaatttca ccgcggttgg cgatcagtac 1677901 ttttgtaaac atgatttcac ctcattgact tgatgataag ttgaacattt caatcgtttt 1677961 ttctcgcagt ttatattttt gaattttgcc tgaggccgtc atcggatagt catccgtaaa 1678021 aataacataa cgcggaattt tgtggcgggc gattttccct ttgcaatagg ctttaagctc 1678081 atcaggtgaa acgcttttac cgtctttcag tttaatccag gctgcagctt cctccccgaa 1678141 tttggcgtca ggcacaccaa ccacctgtac atctaaaaca gcgggatgct ggtataaaaa 1678201 ttcttcaatt tcccgcggat aaatgttctc gccgcctctg atgagcatat cttttaatct 1678261 tccggtgatg cggcagtacc cgtcttcatc catgacagca agatctccgg taaacagcca 1678321 tccgtcatga ttgattgctt ttctggtcgc atctttgtct ttataatagc ctttcatgac 1678381 gtgatagcca cgggtgcaca gttctccctg catgcctctt tgaacttctt gacatgtccc 1678441 gggttctaca attttcacct cagtatgtgg cagggcacgg ccggttgttt cgactcttct 1678501 tatgaaggaa tcatttgctc tcgtttgtgt aatgactggc gaggcttcgg tttgtccata 1678561 ggcgatcgta atgtctttca tgcccatcct ttcaatcaca gctttcatca cttcacttgg 1678621 acagggagag ccggccatga ttcctgttcg gagcgtcgat agatcatatg catcaaaatc 1678681 cggatgatgc agctcggcga taaacatggt aggcacacca tggagcactg tgcatttctc 1678741 tttttctacc gttttaagga cggtaacggg atcaaattct tgcacgggta tcatggctgc 1678801 cccgacggat acacatgcca aaaccccaag gacgcatcca aagcagtgaa aaaacggaac 1678861 agggatgcac atgcggtctt gagaggttaa agccatacat tcagcgatat tagcagcgtt 1678921 attgatgaca ttgaaatggg tcagcatcac gccttttgga aaccctgtcg ttcctgatgt 1678981 gtattgcata ttaatcacat tgtctttatc caggctgttc attctctctt caagctcagc 1679041 atctgtcact gttttcgcca atatctctgt atcgtcccaa tgatacatgc cagacaatcg 1679101 tttattgcca atatagatca gcgtttttaa aaagggatag cgttcagatt tcagttggcc 1679161 gggctttgct tcttgcagtt ctggaattaa actgttcacg atgtctggat aagaagtgcc 1679221 cctgtatgaa tccatgataa taagcgccgc ggcatccgat tgctttaaca agtaatcaag 1679281 ctcatgtgct tgataattgg tattgacggt cacgagcacg gctccgatct tcgcagttgc 1679341 gaactggacg gcaagccatt cagagatatt agaagcccat atggcgacgt ggtctccttt 1679401 tccaatcccc atccgcatga gacctttagc ggtttgacgg cacagactgt caaattgagc 1679461 gtacgtatag cggatatttc ggtctggata cacaacagca tctcgatcgg gatacgcatc 1679521 agctgtttgt tccagcagcc tgccgattgt ggaatggatg agttcagcca ttcattgttc 1679581 ctcctttctt aatgatagga aagcgtttac atttttattt taaaagctgt ctggcgatca 1679641 cgagacgctg aatttcagat gtgccttcac cgatttccat taattttgcg tcccgcagca 1679701 tccgttccac cccatactct ttcatatagc ctgaacctcc atggatttga atggcttgat 1679761 tgcaagctct tgtcgccatt tcagatgcga atagcttggc gtacgccgct tctttggtga 1679821 acgggcggtt atgatctttc agccaggcgg cttttaacac catttgccgt gccagatcaa 1679881 tttccatcgc catgtcagca agcttaaatt gaatcgcttg aaaggaagaa atcggctgtc 1679941 caaactgctt tcgctctttc gcatatgcca atgatgcgtc aagggccgct tgggcaatgc 1680001 cgactgcaag agcagcgatg gagattcgac caccatccag cgtatataga aactgtttaa 1680061 acccttttgt tggatcgcca agtaagttgg ccgcaggcac tcttacatct tcaagcaaga 1680121 tttccgctgt attcgaaccg cggacgccca ttttatcgta cgggctcgta atcgtaagtc 1680181 ctggtgtgtc agttggcacg attaatgcgg agatgatgtt ttttccgtct ttgtttttgc 1680241 ctgttacggc ggttacaata actgtgcgtg cgtagcttgc attagtgatc cagcactttt 1680301 cgccgttgat tacatactcg tcaccatttg aaatcgcttt tgtttgagtg cctcctgcat 1680361 ctgagccggc atttggctcc gtcaggccga atgatccgag tgctgtgcct gaagccagcg 1680421 gcgtcaaatg cgtctgtttt tgctcttctg ttccgaagta gtaaagaggg cttgcgccta 1680481 gcgagaccgc tgcagcatag cttaatccag tactgccgca ggctttgccg acttcttcaa 1680541 ccgctaaggc atatgaaatc gtatcaccgc cagatccgcc gtattcttct ggaaatggaa 1680601 tacccatcag accgagttca cccatttttt taaatgtttg catcgggaac tcgcctgttt 1680661 gatctacatg ttcagcgtga ggagcaattt cttttttcgc aaaatctttt accatttcac 1680721 gcaccatttg ttgttctttt gtcagctcaa aattcacatc gtttcctcct tcacatcttt 1680781 gtaacatcct attaggcgag ttctataatc attccctgac aagaaaagtc tgaaaattaa 1680841 aactgaatca ttttttatgt gataatatca gcgggatgag caaatacatg cagtaggcgc 1680901 ataccatcca tatcgtaaac gcaataactt ggccctttga taaagccggg aagatgaggg 1680961 gaagattcca aagggaaatc gtatccatca ataaaccgac cgctgatccc catataccta 1681021 gcttgatcac cgcgaactgt gattgatcga gtttttgata gagaaagaac acaaggcata 1681081 aaacaagagc agtgcccgct cccaagagaa gaaagttcgg caaaaaggct tcttcagccg 1681141 gatcagtcaa cacagcatct ccgaacagca caaaaaataa tgtggcacct aaccagacta 1681201 gaaatgaaaa cgtaaaacac gtcctgtacg tgtttctctt cgattttatt tttatttagt 1681261 actagtttct cagattccaa taatggtaaa tgtccaaaca ccgcctccat attcatgtga 1681321 atctcacctt tgttttttaa aaaattcagc ggtttaccat cgtttcctgt cccaaaatca 1681381 ctttttaaaa aaagacgact tagaaagccg tccttctcat ttcttatttt gttgttcgtt 1681441 tggaagcttt gctttcgtta tgaagccggt ctgctgaagt gacataatac gtatatttct 1681501 tgttgggatc tgccgtgtta tctaagaagg tttgctgctc atgtgttttt ctttgcgttg 1681561 ccagcaatgt tctctgcttt ttcccttcgg ctctgtatat cgcataatag gctgtttctt 1681621 tcgttttttg atttgatggg tgatctttaa tctgcagaag attgccgttt ttgtcttcgg 1681681 tgactttcgt aagcttcggt ttttttgggg cggtattgtc aagccaaggc atttgcggaa 1681741 ccagtgccgg cttgctgtaa agatcggtgc tgagactgtc tttgatgcca agcggatttt 1681801 tgttgaggtc cttgaggctg aaatgcatgc ttcctttcac cagttcaagc tggcggttca 1681861 aagtgatttg ccgcacatat tcctcaggat cggaccaagg cggatcaaaa ttgttattga 1681921 ttttatatgc tgcctggcca atatataagt gaacaggcct atttttgact tcattgctcc 1681981 accaatcagc cagcacgtcg taagccgctg cgttaaagcc gatactccaa taaatttgcg 1682041 gagcaatata atcgatgtcg ccttcttgga tccaatgcct tgtgtctgca tatagatcgt 1682101 cataatttct gacgcctgct tttgtattcg atccggtcgg gtcatctgcg gcgtttctcc 1682161 atactccaaa gggactgatg ccgaatttga catacggttt tgcagcttta attgtttggt 1682221 tgatttgttt gacaagctgg ttcacattgt cccgccgcca gtcatcgata ttagaaaaag 1682281 cgtcttttcc gtattgttcg tactgtgctt gatcaggaaa ttcctgtccc gctattttat 1682341 aagggtaaaa ataatcatcc atatgaacag catcgatatc ataatgtttt acgacttctt 1682401 caatgccttt gacgataaaa tctctcgctt ctggaatgcc tggatgataa tacagctggt 1682461 ttccataggc ggcaacccaa tctggatgtt ttcttgccgg gtgatcctca gacaatttat 1682521 taagatctgt atgattcatt gtaatacggt aaggattaaa ccacgcgtga aattccaaat 1682581 ttcgtttatg ggtttcttca atcataaatg caagaggatc atagccgggg tccttccctt 1682641 ggacaccggt taagtattcc gaccaaggcc cgtaagctga cggataaaag gcatcagccg 1682701 tcggtttaat ctgaacgata acggcattca ttcccatttt ttgcacatcg tccagcagtt 1682761 tgatatactc ctgtttttgc tctttcacag ataacccttt tttggacggc caatcaatat 1682821 ttaatacgga agcaatccat acggctctca gctccctgtc agactgcgca ttggccataa 1682881 acggaacgga aatgacaaac gttccgatga tcaagctgac aaggaaacgg acaatcgact 1682941 tttggcaaac cttcattctg tttcttctcc cccattacat cactttcact attcgctatt 1683001 acggtattcc cgggctataa aagggtgatt aacagaatgt ctatctcact aaataaacga 1683061 aaaaagtcct aaagcatgtt gtgaaccgct tttaggactt tttatcattc atcatggttt 1683121 gcagactttt taacacatca ataagtttta cgccgacacc gacagccgtt tcaaggatcg 1683181 cttgtgctcc ggcaatggct aaaataaaga tcagcggtat tgcaatacga ggcaaaaaaa 1683241 gatagccaag tccgatcaag atggcacacc aaacaccggc acaccagtag caattgagca 1683301 tgtatccaaa gttagaagcc ggcacgcttt tttcatctac atgcccgttt tgatcaacaa 1683361 tccttttctt tttcataaaa ggttttcgga taaattctgt gattttgtca aatacaatca 1683421 aatgtgtcag cctgtaactg gctagaatca gcatgataaa agttagaaaa gaaagacggt 1683481 ccattgagaa gcctccaaga aaaaggatga tgttatcatt cccaagtgtc ccttatccat 1683541 tcttgataca aaaagaaaga cggacagaga atggcctctg tccgctaatc cgagctcatt 1683601 ccctccagtt ctcataataa gaggataaga aaatgtagaa aaaagcagaa aaatgacaat 1683661 aaaagaaatt atatgactat ataatccata tatgcactat attaacggat attttttaaa 1683721 gtacaataaa aaacattaaa tttttataac attttttttg aatatagtat tatttcttta 1683781 tttttcgttt ctttttttat caaatttccg gatataaagt gataaaagta ttgttttaca 1683841 taaggtctta tacactactt tttaatcgga ctaattttct tttgtgcatc attcttctaa 1683901 ttgttggaag gttcgacaaa gcgttattac agacataaaa aaacctgttt tctcttggaa 1683961 aacaggtctc ccgctattat tgatttgcca aaatgacagc gatttgatcc tcaatatctt 1684021 ttccatcctc ttcatcaatc aatccattta gaagaataga gaaaacaagt ttttttccgc 1684081 tctttgtttc tgcgtacccc gatagagagc ttaccgtact gagcgatccg gtttttgctc 1684141 ttacttttcc ttgtgcagga gtgcctttca tgcggtttct cagcgttccg cccaccattc 1684201 tgtcaggatt ccccgcaaca ggtaaagaat ttagataagc cgagaaccaa ctctgatcct 1684261 gaatgtcata taacagctgt gaaagttgat ctgaggatac agcatcaata tgtgagattc 1684321 ctgatccgtc ccttaagacg agtgatttag aatcaacacc aaattccgga agcgtactgt 1684381 ttaacacttc gagccccttt tcccagctcc cttctccttt tttcactttc cccatctctt 1684441 ttacgagcac ttcggcatgt ccgttattac ttaatttcat gaacggcaca aaaagtttcg 1684501 ataaaggcat tgagcgatga gagagcagca catctgaaga actaggtgct tcacccgtct 1684561 tgatgtcccc tttcacagta ataccttgtt tttttagtga ctgcttaaat aaatctaagg 1684621 catatccggc aggctcccag acagaaatcc attcctttgt cttgtttgcg tcaaccggta 1684681 cgctcccttc aattgtaatc gtgtttgttc catgctctct ttcgattgtg aggtctttct 1684741 ctgaaccggc agcagtcgtt ttagcatcgt tctttatcgt tatataatcg gttttcggag 1684801 agacagacac ggcaggctct tccccttctt tttgatttgg ggtgacctca acaatcacag 1684861 tgcctgcatc atagtcttcg tttggagacg ctgttagagc ggagattggc gcgccataat 1684921 atgtgtattc atcgctccaa ggcatatcag gtgataatcg catgtcatca tgccacgtat 1684981 catcaccgat cagattgcct ttaattactt ttacgccgga atgtttcaat atctcagcca 1685041 ttttgtcaaa atcagatggt aaaagtgtcg gatcgccttt ccctttcaaa taaaggttac 1685101 cattcagctt tttccctttc agtgttccat ccgtccggac ctcggttgta aaagaatagt 1685161 tctcgccaag gacagaaagt gccgcggccg ctgtcaaaag ctttagagaa gaggcaggcc 1685221 tcattcgggt gtctcctgaa tgttcatata gaacagcacc tgtttccgca gagcgaacgg 1685281 tgatgccggc cattgcgcct tcgagggcag gatgatcagc taaaatctta tcgatctgcc 1685341 cggaaagtgc atcttgtttt tcagcggcaa gcgcagcctg atgcatataa ggcaccgaag 1685401 caacgacgaa aagcagtaaa acagcaacat aaagctttat gctttttttc attaatttcc 1685461 ccgcctctct gcgcttcatc attggctatt gatgattcag ttcaatggtg atactgcttt 1685521 tagctgtcgt ttcttctccc ggctccagca cttgtaaacc agtgagtgac gaaggtaaat 1685581 caagattcac tgcgtttgtc acccatgtgt aaggctcagg gcataaatac ccttgttttc 1685641 cgtccgcatt gtatacaacc caatgtttaa actgttcatc tgccttataa ataatgctga 1685701 tatgtgcatg ctgatgataa atgactgcct ggttttctcc gcccctcttc tgataagaag 1685761 ataaaaagac atcatccagc tgcttgtggc gcaaatccat tccttcatgc aaagcttctt 1685821 tatacgggac atccatcagc ttcccggtcg gcagcaggcg ttcatccaac tcccattgct 1685881 gatctgctgt cagggagaat aacgagcttt ctgccggaaa tataaatgta gtatgataac 1685941 caattcccca aggaaacgct tcctttcctt tgttcatgac cgtcgcatgt ttaaataggg 1686001 tattctcctt gatcgtgtat gtcatccgaa cgacggcatg atgaggaaat tgcttctgca 1686061 catggggaag ctcagaaaga tcaatttctg tttcaacaat cactccttca tcagtttgct 1686121 tcgtggtcac gacattccac ttttcatggt aaagaaaccc gtgaagatgg ttgtgtttat 1686181 ccttctcgtt gatatcaaaa tgatacgttc tgccccggaa actgaatgta ccgtcactta 1686241 tgcggttagg cgggaacagg attggaatgc catacaatgt tggtgtgtcg tgaaaacttt 1686301 ctgctgtttc cggttcacgc aaaagctgga catttgttgt tttgtccacg agagaaatga 1686361 cgttgctccc ccactcaggg acaacaatca tttctagatg ttcgttgccc gctttgatgg 1686421 ccggcgttcc caaatacgtg attttctcaa taaagtttgc catgtttact caacctctcc 1686481 ttgattcatt gctagtataa gaattcaatg tactgtacca tatttcctcc attttatatt 1686541 ttcccctatc aaataaaaaa acaccgttca aacttatgaa cggtgtgatt cggaggctat 1686601 tggatgagac gtgtgatttg tttctttttc cagacgaatt gataataccc ataaatcaac 1686661 agcaagctga cggcaaacgc agctggataa ccaacccaga cgccgagtat ttcaagcttt 1686721 gtatagtgag aaaggacgaa agcgacaggc acctctactc cccagattgc aaaaatactg 1686781 atgacggtcg gccataaaac tgttccgctt gcccgcatcg ttgcagaaat aatttgggca 1686841 tttccaaaca gcaaatagct ccacagtgta atcatcaaaa gacggtgcgc aatgtaaagc 1686901 gtctcttgct cggttaaaaa taacgataaa atctgatgtg aaaaaacata gatcagaatg 1686961 atcagtacgc cgccaatgat ataattcagc caaatcccaa cgcgaatgac ctgctttaag 1687021 cggtcaaact cgtttgctcc gatcgattgc gcagcgaaaa tagaaaccgc aataccaagg 1687081 ctgacggccg gcatctgtac atagctggcc acctggttga ccactccgta tgcagctgtt 1687141 gcattagagc cgtaatgatt gacgaatgaa ataaccgcta tctctgataa tgagacaaga 1687201 atcatattga tgcttgctgg gaccccaaga cgcagcagga gaaccagcag ttccttatcc 1687261 attttcaaat aacgacgcac tgttttatca aattgcagcg ggtgttttcg ctttcgtaaa 1687321 tacaccatta acacgagaaa agtcgcaatc gtggaaatga cagttgcata tgccgagccg 1687381 tatatgccca gtttcggaaa accaaacatg ccaaggatta aaacaggcaa aagcgcgatg 1687441 ttgatgaccg tgctcacaat cagcgtataa aacggtgtct tggaatctcc tgttccgcgc 1687501 aaaaaggtag tatatgcaaa atataaaaac ataaacggca tagcataaaa taaaatacgt 1687561 gcatagttag cgctgacatg aatgacattt tcaggtgttc ccattaaacg aaggatatcc 1687621 agggtgaaaa tactgccgat aacggctaac acaacgccta ataaaaatgt aaacgtgagt 1687681 gtcgtcccga caacagcctt tagccgttcc tcatttttcg ctccgtaagc ttgtcctatc 1687741 agaatcgaac ttcctgaacc gatcccaatc gtaaatgaga ttaaaagaaa aaataacggg 1687801 aaaaaggatg atacagctgc cactgcatca acaccgagcc atctgcctac agccatcatc 1687861 ccgactagct ggccgactga ttgcagcaca ttgctcagca gaagcggcac taaaaagagt 1687921 gacatcgacc gccaaactga tggtttgctt ttcttttgag ttacaagagg ttcttgtgat 1687981 gtttccatat taaaggactc ctttatttga aatcgttttt aaacatgccc tcattttttg 1688041 acaaaaacag gatatgtaac atgttattat tcatcactgc acttatgaaa cccttcccga 1688101 ttcttctaat tttacacatc tttttagctt atgaagaata aactagcaag taatggcgta 1688161 ttttttgtga gtaaaagaat aaaaaataat ttatgcaaaa gtattgtaat ctatccgtaa 1688221 ttattgtaac atttgtaaca taagagaaag agattttgaa ggagagagcg ataatgaaaa 1688281 aatgtcttct atttctaaca accattgcac ttattctgtc attaagcaca aatgcatttg 1688341 cgaaaaatac atcaggcgat ttatcacaaa aacaagcatt acagttggca ttatccgcta 1688401 gagaacattt ttggaacacc atgagcggcc acaatccgaa ggtgaaaaaa gcagtttgcc 1688461 catcaggcac attcgagtat caaaatcttc aatatgtata catgtgcagt gatctaggca 1688521 ctaaagcaaa agcggtgaat tatttaactc ctatttttac aaaaacagca atcgaaaaag 1688581 gctttaaaga ttatcatttc actgtttcaa aaggaaaact tgctgttcca atcggtgacg 1688641 gagacaatct tttgaattgg aaaaaatcaa ctgctaaact gatctctaaa aaaggcagca 1688701 caatcacata cgaatttact gtccctacat tagacggatc cccttctgca aaacggaaag 1688761 tgacatttgt gaaagaaaat aaaaaatgga aagtcaatca atttgacgca gttatataag 1688821 aaaaacgccc ggtataagcg ggcgtttttt atttggtttg cataaagaaa gacaacaggc 1688881 gaaaagtgcc tgttgtcttt ttgtgaatat aacgctctag gagagattcg aactcccgac 1688941 ctgcagttta ggaaactgct gcactatccg ctgtgctact agagcttttg gtatttatat 1689001 agtagctctg atgatcaata ttttcaagcg atttgtatta aagccctcca aaaaccttat 1689061 atgcggctct tgtcgtatct tcatcaatac cgatataccg cattgtaatt gatggtgatg 1689121 aatgattcag tattctctgc agctcggcga tgtctttcgt tcgctgataa aaatgatagc 1689181 caaacgtttt ccggagtgta tgcgtcccta tctcctcaag tccgcacgct gcagcggcct 1689241 ctcttaaaat tctgtaggcc tgaatgcggg aaatcggctt cctggtccgc actgatttaa 1689301 aaagatattc gttttccttc atgtctttcg tatactcgta tatttcctgt ttcagcgatt 1689361 ctaaaataag aatctttctt ttctttttcg ttttgctttc agtcgcccat aaatgatctt 1689421 tattttgaac gtccttcact tgcagcggca gaatatcaga aatacggagc gcgctgttga 1689481 tgccgaaaat aaacagaaaa taatcccgct tgtttttgtt aagcaaatac tgtttgactt 1689541 cttggatttt ctctagactg cgaatcggct gtacaatatg catcaaaaaa ctccttaaaa 1689601 accgttatgt aacattttga ggtctatgtt actattatag ctgaaaaacg ttgaatgtca 1689661 aagtgcggcg gcgtttatgt aacataatat acatagtgtt acataagctt ttaaaaaagc 1689721 ttcttccaac cttcacccta taaaataagc tttaaagcct cttataaagc ttttaacctc 1689781 ttggatactt atccccctac taatcatcaa aaaacctctt aaaatgaaat ctgacactcc 1689841 caattttctg gagcttccgc aaaaatatac aaaaaaagac acaatttcaa attgtgtcct 1689901 aatcctcatc ctttacatca atatcttccg ggatcggttc atttaatatt tcctgcacaa 1689961 gtgctttgta attctccagc tgttcgagat gcgttttgaa ctgttcctta taaatcaaaa 1690021 attgctcccc gtcatgaacg gctctgattt tcccttcgag caccaagctt ttaatataat 1690081 cctctgaaag atttgtatat tctgctgttt cttcaatcgt taaatacata tagcagtccc 1690141 ttcttaatcc gtatgctgat tctaatatag cacatggctc atatcaatat aatcaattct 1690201 gcacagaaaa acggcattat gcactatata atataccatt tgtcacttgt gaaaacgctg 1690261 taattttttt acgctaagat tgtaacaata cagcttcata taggagggag aacatgaaaa 1690321 gaacgtggaa cgtctgttta acagctctgc ttagtgttct gttagtcgct ggaagtgtcc 1690381 cttttcacgc ggaagctaaa aaaccgccca aaagctacga tgagtacaaa caagtagatg 1690441 ttggaaaaga cggcatggtt gcgaccgcac atcctcttgc ttctgaaatc ggtgctgatg 1690501 tgctgaaaaa aggaggaaat gctattgacg cagcggttgc cattcaattt gcactcaatg 1690561 taacagagcc gatgatgtca ggtattggcg gcggcggttt tatgatggtg tatgacggaa 1690621 aaacgaagga tacaacgata atcgacagcc gtgagcgtgc tccagcaggc gcaactcctg 1690681 atatgtttct ggacgaaaac ggcaaagcaa ttcctttctc tgaacgtgta acaaaaggta 1690741 ctgccgttgg tgttccaggc actctgaaag ggctggaaga agccttggat aaatggggaa 1690801 cccgttcgat gaagcaatta attacccctt ctattaaact cgctgaaaaa ggctttccga 1690861 ttgattcggt gttggcagag gccatttctg attatcagga aaagctttca cggactgccg 1690921 caaaagatgt atttttacca aatggcgaac cgcttaaaga aggagatacc cttattcaaa 1690981 aggatttggc taaaacattt aagcttattc gctccaaagg cactgacgct ttttataaag 1691041 gaaaattcgc caagacgctt tctgacactg tccaggattt cggcggatca atgacagaaa 1691101 aagatttaga aaattacgac attacaattg atgaaccgat ttggggagat tatcaaggct 1691161 atcaaatcgc tactactcct cctccaagct ccggcggtat tttcttattg caaatgctga 1691221 aaatccttga tcattttaac ctttcacaat acgatgtccg ctcatgggaa aaatatcagc 1691281 tgcttgctga aacgatgcat ttgtcatatg ccgaccgtgc gtcttacgca ggtgatcccg 1691341 aatttgtaaa tgttcctctc aaaggcctgc ttcaccccga ttatattaaa gaacgccagc 1691401 aattaatcaa cctagatcaa gtgaataaaa aaccgaaagc cggtgaccct tggaaatacc 1691461 aagaaggatc agcaaactat aaacaagttg aacagccgaa agacaaagta gaaggccaaa 1691521 caacccactt tacagttgct gaccgttggg gaaatgttgt ttcttataca acaacaatcg 1691581 aacagctatt cggaacgggt attatggtcc ctgattacgg tgttatttta aacaatgaat 1691641 taacggattt tgatgcgata ccaggcggag ctaacgaagt acagccaaac aaacggcctt 1691701 taagcagcat gaccccgacg attttattta aggatgacaa gcctgtcctc acggttggat 1691761 ctcctggcgg ggccacaatt atttcatccg ttttgcaaac cattctctac cacattgaat 1691821 atggtatgga attaaaagca gctgttgaag agccgagaat ttacacaaac agcatgagct 1691881 cttaccgtta cgaagacgga gttcctaaag atgtcctcag caagctaaac ggcatgggcc 1691941 acaaattcgg cacaagtccg gtggatatcg gaaacgtgca aagtatatcg atcgaccatg 1692001 aaaacggcac ctttaaaggt gtagctgatt caagcagaaa cggcgcggcg atcggcatta 1692061 atttaaaacg taaataaata aaaaactgta ctcgcttcaa atgagtacag ttttttcatg 1692121 cagatcttta aaataaaaac tgacaaacgt ctttattctg ctaatgcacg tctatcttca 1692181 tcttttcatt tcgtttatct catcaagaaa tgtctgaaac gcactcgtaa taaaaaagtc 1692241 tttcctgtat ataaagacga tctctaagtc ttgatatgat ggtggcagct gatgaatcca 1692301 tacatttgta cgatgctcgg agccgtcaac agcggacttt gggagcagcg ccgtacccat 1692361 cccggcggaa acacctttta taatagcctc caatgtgcca aactctatga ttttttgatt 1692421 gtgtatgcct gcttcctcta gtaatctttt gaccctgtca cgatgagaac agccagcccc 1692481 aaaaaagagc atcggctgct gaagcatgtc ttctgccgtc ccttctcgtg atgaaatcaa 1692541 aactaattca tcatgggaga catggagttg tctaactgca gcgtgttcaa ccggcccata 1692601 tacaaaagcg ccatcaactt tatgatcaag aacctgttga atcaaatgat gcgtatcagc 1692661 tgtgttcact gataaatcca cttcaggaaa acgcctgagg aaggatgctg catgctcagg 1692721 cagatgcgtt accgccattg tttccagtga tccgatccgc aaaggccctt ttggttgcct 1692781 gctcattcgg gtcgattttt cagcttggtc taacagcgat aatacttgat ctgcatattg 1692841 taaaagattt tctcctgcag cagtcagctt cattccccga ttcgttcgat gaaaaagcct 1692901 gatattcaaa tcttcctcaa ggttatgcac tctggctgtc acattcgact gaacataatt 1692961 cagcatttgg gctgctttcg ttatgcttcc ttcgcgagca acagcctgaa aaatctttaa 1693021 atctccgctt tccacgcgct ctcacctgct tgctatgatg aaaagtgata ttggctatca 1693081 tatttgttca ttttactcga agaaaaccgc tatgtaaaat atgtaaagat atgaaaatac 1693141 aattaatgag gaggcagaca gcatgaaagc tgtaattcac aacggaaaag ccggtcttct 1693201 ggggttatca gttcaggacg ttccatcaac aaagcctgga tacggagagg taaaggttaa 1693261 attaaaatct gcaggcctga atcatcgtga cttgtttctt atgaaaaaca aatctgaaca 1693321 agatcctcac atgatactgg gttctgacgg cgcgggtatc atcgaagaga ttggtgaagg 1693381 cgtgaaaaat gttactgttc agacagaagt agtcattttc ccgacattga actgggattt 1693441 gacagaaaat gttccacctg tacctgagat tctgggaggt ccttcggacg gaacacttgc 1693501 tgaatatgtg atcattcctt cacaaaatgc aatcaaaaaa cctgcttatt tatcttggga 1693561 agaagcgggc gttttacctt tatccgcttt aactgcatat cgggctctgt ttacaaaggg 1693621 gcaattaaaa aaaggcgagc atctattgat acccggcatc ggcagcggtg tagcaaccta 1693681 cgctttattt atggctaagg cgattggggc aacagtaagc gtgacctccc gcagtgagga 1693741 gaaaagaaaa aaggcgctga aattaggtgc tgattacgca tttgacagct acagcaattg 1693801 ggatgagcag ttgcagggaa aaaagataga tgttgttctt gacagcatag gacctgccct 1693861 cttttcggaa tacttccgcc atgtaaaacc aaatggccgt attgtcagct ttggggcaag 1693921 ctcaggggat aatctcagtt ttccggtgcg ttctttattc tttcctcagg tcaatgtttt 1693981 gggaacctcg atgggaagcg gtgaggaatt tcaagctatg ctcgctttca ttgacaaaca 1694041 taagctgcgg cctgtaattg accggatata tcctttagaa aaagcatgtg aagcatataa 1694101 aagaatgcag gaaggcagac agtttggaaa catcgggatc gtaatggaat aaaaaaagaa 1694161 accggctggc agccagaccg gtttctctta tatgataatc ccctttattt acggaagaac 1694221 tgaactcccc atcaaatatc gatccacttc acgcgccact tcacggcctt cattaatcgc 1694281 ccatacgatt aagctttgcc ctcttcttgc atcccctgcg gcgaatacac catcgatatt 1694341 tgtttgataa tccccatatg ctgcactgat tttgttattt actgaattaa caccgaactg 1694401 tttcaacagc ggctgttctg tgccttcaaa gccgatagcg ataaagacaa gctgagcagg 1694461 ccatactttt tccgttccag gcagctcgcg gaactcgtat tttccatgct catttttcac 1694521 tttttccatt tggatggtat gaagctcttt cagctttccg tttttatccg cgaccatttt 1694581 tgtcgtttga atggagtatt ctctcggatc tcttccgaat tttgcttctg cttcctcgta 1694641 tgcatattca agcgtaaaga cgtgtggctg ttcaggccac atattgtcat tcgtgcgggc 1694701 tggcggaagt ttcgggtgtt tgccgaattg gtgcacgctt ttggcttttt gacgcagagc 1694761 ggtagccaca cagtcagctc ctgtatctcc gcctccgatt acgatgacat ctttcccttt 1694821 ggcatcaatg aattgcttgt ctttaaaatt agaatctaaa tagctttttg ttgcaagtgt 1694881 gaggtagtcc attgcgtaat ggactccttt tgagtcgcgt ccttcgatta agaggtcccg 1694941 ctgtttttga gcgcctgtgc ataagatcac agcatcaaat tgctccttta gctcatcagc 1695001 tgtaatgtca acaccgattt ctgtgttcgt gacaaaatca attccctctt gcgtcagcaa 1695061 tttaattcgg cgttctacaa tgcccttctc aagcttcatg tttggaatgc cgtatgttaa 1695121 aaggccgccc gctctgtctg ctcgttcaaa aacagtgacg gaatgtcccg cttgattcag 1695181 ctggtcagca ctcgccagtc cggctgggcc tgacccgacg atggccactt ttttgcctgt 1695241 tcgttttttt ggaattctag gttgaatcca gccgttctca aatcctttat cgataatggt 1695301 ccgctcgatg tttttaattg atacggccgg atctgaaatc gctaaagtgc atgatccttc 1695361 acaaggagcg gggcataccc gccctgtgaa ttcaggaaag ttgtttgttt tcaacagacg 1695421 ttccaatgct tccttccatc tgccccggta gacaagatca ttccattcag gaattaagtt 1695481 gtaaatcgga cagccggatg taaatccgtt aatgtccgca ccgatctggc aaaacggtgt 1695541 accgcaatcc atacaccgcg ccccttgccg tttcgatgct tcttctgaaa aaggagcaga 1695601 atattctttc caatccttta agcgagtgag agggtcccgc tccgcaggtt tttctcgttt 1695661 gatctccata aatccagttg gtttccccat gttcctctcc ccttccttac tgtactaccg 1695721 cttgtttttg tcccgatgct gctgtattct gctttggctt cgtgttggcc tcaaaagcga 1695781 acatgatggc ttcttcatct gataaacctg cagctttttg ctcttcgatg cttgcgagca 1695841 tttgtttata gtttttcgga atgactttga cgaatttttt cacactgtct tcccattgat 1695901 ctagcagatc ttctgctttt tggctgtttg tatacgcagt atgtctttca agcattgctt 1695961 tgatttgctg gatttctttc tcatcctcta atgattcaaa taaaatcatc tcaaggttgc 1696021 atttgcgttt aaacgctttg acatcttcgg tcagtacata agcgattccg ccggacatac 1696081 ctgccgcaaa gtttttgcct acatcaccga gaacgacaac gctgccgcca gtcatgtatt 1696141 cacagccgtg gtcgccgatg ccttctacaa ctacgttcac accgctgttt cgaacggcaa 1696201 agcgttcacc agcacgcccg ttaatatatg cttctccgct tgtcgcaccg taaaaagcca 1696261 cgttgccgat aatgacattg tcatccgaag cagagttgaa tccttctgat gacttgacga 1696321 tgatttttcc gccagaaagc ccttttccga cgtaatcatt tgagtctccg tccaaataaa 1696381 gcgtcatccc tttaggaacg aaagctccaa agctttggcc ggctgatccg gtaaagtgca 1696441 gcttgattgt atcttcagga agaccttctt ctccgtaacg ctttgagatt tcactgccgg 1696501 ttatcgttcc ggctacacga tttgtattat tgatttcaat cgaaatatca gcttcttttc 1696561 cagattcgat ggcttcttgt acggccggga gaattgttgt aatatcaagt gattgatcaa 1696621 ttttatgatt ttgcggcgat tggaacgtcc gcaccccttc aggctgataa agaagggtag 1696681 acaaatcaag ctggcttgct ttccagtgct cctttgcccg ttcacttgca tgaagtacat 1696741 cagtgcggcc gatcatttca tcaaatgtct tgaagcctaa cgcagccatg tactcacgaa 1696801 cttcttcggc aatgaacagc atatagttca caatatggtc aggatctccc atgaactttt 1696861 tgcgaagctc tggattttgt gtcgctacac cgacagggca tgtatccaaa tggcaggcac 1696921 gcatcatgac acagccgagt acaactaacg gagccgttgc gaaaccaaat tcttcggcgc 1696981 cgagcaaggc agccatcaca acgtcgcggc ccgtcatgag ctttccatct gtttctaata 1697041 caacacggtc acgaagtccg ttcagcatta gtgtttgatg tgcttctgca aggccaagct 1697101 cccacggaag ccctgtatgt ttaatactgg ttttcggaga agcgcctgta cctccgtcat 1697161 agccgctgat cacaatgaca tctgcagtcg ctttggcaac acctgcagcg attgttccta 1697221 cacctgcttt tgacaccagc tttacgctga ttcttgcgtc acggttggca tttttcaaat 1697281 cgtggatcag ctgggctaaa tcctcaatcg aataaatgtc atggtgtggc ggaggtgaga 1697341 ttaatccgac acctggcgtt gacccacgga catcggcaac ccatggatat accttgttgc 1697401 caggaagctg cccgccttca cccggcttag caccttgagc cattttaatc tgcagctcat 1697461 cagcattgac gaggtaatgg cttttgacac caaaccgtcc ggatgcaatt tgtttgatcg 1697521 cacttcttct atcatcgccg ttctcatctg gaacaaagcg tttgggatct tctccgcctt 1697581 caccgctgtt gctttttcct ccaagacggt tcattgcgat tgctaaagct tcgtgcgctt 1697641 ccttactcaa ggacccgaat gacatcgcac ccgttttaaa acgtttgaca atcgattcag 1697701 cggattcaac ctcctccaac ttcaaaggct tgcggtttcc gtcaaatgcg aacaagttcc 1697761 gcaaaaatcc gatgcgttct tcatcagccg cttttgtata ctgtttaaac agattgtaat 1697821 catttctgcg gcacgcccat tgcaaagtat gaatcgtttt cggattaaac gcatgatgct 1697881 ctccgccatt tctccattgg aagtcacttc ccggttcaag cgttttgctg taatcatcct 1697941 gatacgcttc ccggtggcgg cgctgtgcct cttctgcaat tgtttgtaaa tcgatgccgc 1698001 ctagctgtga tgcagtacct gagaaatagc ggtcgatcac atcgcggctg attcctaccg 1698061 cctcaaagat ttgtgcgcct ctgtagcttt gcacagttga aattcccatc ttggacatca 1698121 cttttacgac gccctcagta atgctttttc catatttgct aaccgcttct tcatagctga 1698181 tatccaaacg gccttcatca atttcctgct tgtaggtcgc ataagcgaga taagggttaa 1698241 tcgcatctgc gccataaccg attaacgctg caaagtgatg cacttcacgt gcttctcccg 1698301 attccacaat aatgctgacc ttcgtacgca gccctttgcg gattaagtgc tggtgcagtg 1698361 cgcttactgc cagaagcggc ggaattggtg tcagtcgttc gttcatcttt ttgtctgata 1698421 aaattaacaa acttacgcct tggctgatgg ctttctctgc ctgtgtgaac atgtccttta 1698481 aaccgcgttc aagatcctct gaaaacagca catcaatttt ttggcttttt aaatcaggat 1698541 gaacaatcgt tttcaatgcg taaaactgtt cattggataa aacaggtgta tacagtttaa 1698601 tccggcgaac atttcgttca cttggatgaa gaagatcgcc ttccgcaccg agccaagtca 1698661 tcgttgaagt gacaagctgc tcacgaatcg cgtcgattgg cgggttcgtt acttgtgcaa 1698721 acagctgttt aaagtagtta aacagcgatt gcgctcggtc agaaagtaca gcaagcggag 1698781 cgtcattccc cattgaacca aggggatctt tgccttcttt aataacagga attagatact 1698841 tttggatatc ctcatatgtg tatccgaatg ccttctggcg agtaagaaga tcactaaatt 1698901 gttcttcttc tcttgactcc ggatcaggat ttacttgtac aagctcttct tcaagccatt 1698961 tttggtacgg atactcagtt gcaatttgtg ttttgacttc ctcatcggag ataatacggc 1699021 cttcttccag gtcgattaaa agcattttcc caggctcaag gcggttttta tataaaacgt 1699081 tctcctgttc aacttcaata acgcctactt cagatgagaa aataatataa tcatcttttg 1699141 tgacataata acgggccgga cggagaccgt tccggtcaag gatcgccccg atttgtttac 1699201 cgtcagtaaa tgaaatagct gtcggtccgt cccaaggctc catcagggag ctatggtact 1699261 cgtagaacgc ccttttttcc ttggacatat gcgtattttc cgtccaaggc tctggaatga 1699321 gcatcattgc cgtatgtgcc ggtttgcgtc cagccatcac aaaaaactca aatgcgttat 1699381 ccaaaatgga agagtcactg ccatcagcat tgagaatcgg caaaatcttg tttaagtcct 1699441 caccgaagct ttcagaaaca aattgctgct cacgtgctct catccagttg atatttccgc 1699501 gaagggtgtt aatttcaccg ttgtgaacca aatagcggtt aggatgcgct ctttcccatg 1699561 tagggaatgt attggtactg aagcgtgaat gaacaagcgc aaaagcagaa acgaatgctt 1699621 cgtcttgcag atcagaataa aatgcatcaa cctgttcagg tgttaaaagg cctttgtaaa 1699681 caatggtctg gcttgaaaga ctggcaaaat aaaaatcaag accttccgtt actccccaat 1699741 tttcagcctg tttacgaatg acatacaatt ttcgttcaaa agataaattg tcctttagat 1699801 cagaacttgc gccgataaat acctgacgga caaacggaca gcttttttgc gccactgttc 1699861 cgatttttcc gacatttaca ggtacagttc tccatccaag aacgacttgg ccttcttgtt 1699921 caattagtgc attgatttgc ttttcaattt tttttctttc atcttccttc tgtgagaaaa 1699981 agaccattcc taccccgtaa cgttcttttt ctggcagatt gatgtttttg cactcttttc 1700041 taaagaaagc atcagggatt tgaaccagta agccggctcc gtctcctgta tccggatcac 1700101 tgccttgccc tcctctatgg tctagctggc aaagcatctt aagtccttgt ttgacaatgt 1700161 cgtgagtctg cttgcccttt aagtgtgcat ataggccgat tccgcatgca tcatgttcaa 1700221 attcaggacg gtagagacct tgagcttttg gcatttgatt gtacgtcata attcctctcc 1700281 cccgatcaat ttccgataat accggtcata aaatctaaca actctataat cattgtaggt 1700341 tttcaaaacg atataaacaa tatataattt agatcaaaag aatctcaaaa tgagatagat 1700401 ggatgtgaga caaacatgga gctgcgccaa ctgcgttatt ttatggaggt ggctgaaaga 1700461 gaacacgttt cagaagccgc tgatcatttg catgtggccc aatcagcaat cagcagacaa 1700521 attgccaatc ttgaagaaga attaaatgtg accttatttg agcgtgaagg gagaaatatc 1700581 aaactcacgc caatcggaaa agaattttta attcatgtga aaacggcgat gaaagccatt 1700641 gattatgcga aagagcaaat tgatgagtat cttgacccgc atcgcggaac ggtaaagatc 1700701 ggctttccta caagcctcgc cagccagctt ttgccgactg tcatttcagc gtttaaagaa 1700761 gaatatccgc acgtcgaatt tttgctgcgc caaggctcct ataagtttct gattgaagct 1700821 gtcagaaacc gcgatattga tctggcctta ttagggccgg tgccgacgaa tttctctgac 1700881 ataacgggaa aaatattatt tactgaaaaa atttacgcgc ttgttccatt aaatcatccg 1700941 cttgctaaac aaaaaacggt tcatttaatc gatttgcgca acgaccaatt tgtattgttc 1701001 ccggaaggat ttgtacttag agagatggca atcgatactt gcaaacaagc aggctttgct 1701061 cctctcgttt ccacggaggg tgaggatttg gatgcgatca aagggttagt gtccgcagga 1701121 atgggcgtta cccttctgcc tgaaagtact tttgctgaaa caacacctcg ttttactgtg 1701181 aaaattccaa ttgagttccc tcaagtaaaa cggactgtcg gaatcattaa accgaaaaat 1701241 agagagcttg cgccttccgc gaatgatttt tatgagtttg tcattcaatt tttctctaag 1701301 ctggagcagt atcaataaaa aaaatgaacc cgagcttcta tatagaagct tcgggttttt 1701361 ttctgcaaat taatttacag gtaaagaaaa atccacatgg caaacaaatg cttcttgatc 1701421 aattagagct ctatttgtca gttccttttt cttttccggt tcttgaagct gtacagaaga 1701481 gtaattgacg attccaaggc cgatttccgt cccttttgaa tccatcagcc gaacaactga 1701541 accgcttttg aatttccctt taatcttctg tacaccgtct aggtataaac tcgattgtcc 1701601 gtttgttatt tttcgtgaac aatcatctga taaaatcatt tcaccttccg gaccggaatt 1701661 aaaagcgatc cattgctcct tttgattcaa cggaagcgtt ccttctgctt caaaataggt 1701721 gccttccgcc tgttcatgaa cggcgtggta taaaatatcg ccagcatctg cctgacctag 1701781 gaaaccttta atgccagacg ccattacgat tttaaacgca tcaagcttag agcgcatgcc 1701841 gccggtgcca acgatgcttc cagtgtcacc tgcgcatgct tcgatgtcag gtgttatttc 1701901 actcacccgc tgtatctttt tcgcttctgg atttgtgcgc ggattgccgt catataatcc 1701961 gtctatatct gataaaatca caagcatatc tgcatcaatc aatcctgcga cttttgctgc 1702021 gagcgtatca ttgtcgccaa acttgagccg attgacggta actgtgtcat tttcgtttat 1702081 gatcgggatg atgccgcgct cgagcagtac attcattgta ttcctgacat tgttgtatcg 1702141 atattcatca gaaaaatcgc ttctcgtaat taaaatttgg gatgcgacat agccgtgtgc 1702201 caaaaacagc tttgaataag cctccattag caatccctgg ccgattgaag ctgatgcttg 1702261 tttttctgga agcttctcgg gcctttggat aaatccgagc ttccgatatc ccgccgccac 1702321 tgcgcctgag gaaaccaaaa tcacttcata accggcgtct ttgagtttga cgacctggtc 1702381 gaccaacgct tctaattttc gaatgctgat ttctccatga aggcttgtta atgaactgct 1702441 tccaatcttc acaacgactc ttttcatgct tgtatcaggc gtcactttat cactcctgat 1702501 agcggcgctg cagttttttc gatatcttcg ctgatttcct ttgaacgctt agccgcatgc 1702561 tttattgctt gagaaatcgc ttctccgccg ccgctctttt tcaaggcttg cagccccgct 1702621 gctgtcgttc cgttcggtga cgtgatatta tctcttaaga tctcaggatg ttctcctgtt 1702681 tccatgagca tttttgcggc acctaaaagt gtctgtgcgc cgatgcttcg agataactgt 1702741 ttatcgaggc ccgcttcctc gcctgtcttt tcaatgaatt ccattaaata ataaaaatac 1702801 gcgggtccgc tgcctgcaat tccggtgaat atatccattt gattttcttg gattgtatag 1702861 acttcgccca tgcatccgag caatgcttcg gccagcttct tcaggtcttc cgacacatat 1702921 ttgccaaggg caatagctgt tgcagaagcg ccaatcatac tggaagtgtt gggcatcact 1702981 ctgacaaccg gctgttcatt aagcaatgat tgttcaataa aagaggtagt tatgccggca 1703041 aggaccgaca atattaattg atggggttga atacgtgatt ttagtgatga cagagcgttt 1703101 tcggcgtctt ttggcttcat tgccaaaatg agcacatcca tgtcttcaat acatagttgg 1703161 ttcggcaagg cgcctttaat gccatattga agttcaagtt cagttaatcg ctctgtattg 1703221 ctgcggtttg taacgcagat gttttgtttc gggattttgt tggctcgaac gatacctgat 1703281 atcattcctt ccgccataga tcctgctcct ataaaggcta ctttcttttg atcaaagatc 1703341 ggtaacatct cctttgttcg cttttttgtt cgcattttca cacgtttaaa atgttaccac 1703401 gtgaggaaat gatgtcaagt ttgaaggcca ttattgattt gtattgtttc ttttcgacaa 1703461 atatgtataa tgaaaagcag aaaacacccg gttcacactg ctgcgccggg tgtttgtttc 1703521 tattaaaaat tatctgagag agctttttca atcagttttt tacagcgatc cagctctacc 1703581 ttcagctgtt ttttatatag cttggcagct tcgtaatctt taaattgata gaggacgact 1703641 tcctggagct tagccccttc tttttttact ttaatttgtt ttagtatccc gtcatcaaga 1703701 agctcatgca aagaccggta tacttctgta tgatttggtt taaaaccaat ctctttaaat 1703761 tcagaccgaa gtacttcaag cagctttaac ccatagagtc tctcttgctc tgtcatcgtt 1703821 atcatataaa gcttcaaaaa tgcgcgctgt ttcactaaaa agcctgttga actccttttt 1703881 tcttctttca tcatatgcac tccttcttct gtcactgaca acactatgta ctaaatattc 1703941 aattttcttt tattgttttc cttctttata ttaaagactg atagtccagt tatttcatgt 1704001 ttactgatta taggtgtagc ggaaaaaata aatttcgact gaacatttgg tacatagttt 1704061 tcttagttct attatagcct gcatttactg ctatcttcaa tttaaacgat tgccagggtt 1704121 tacatatctc attttaccgg tacggatttc attcaaataa aaaaacctgt cgaaagacag 1704181 gttttcattt ttaaggattt gttgaccata atcccgctgt tttgatgaaa atacgaggat 1704241 ctaatttcag ttgtgccacc atgtactcag caagatcctc aggctgcata actttttcag 1704301 gattaccgtc tgttaagttc aattcgatag acatatcact agcgacagtg ctcggcgtta 1704361 acgcgctgac tctgatatta tgttttctca cttcttgcat aagagactct gttaacccga 1704421 gaacggcaaa tttagaagcg ctgtaagcac ttgttacagc agctcctctt tggcccgctg 1704481 tagatgaaat attaatgatg tctccggctt tgcgttcgat catttccgga agcaccgcgc 1704541 gagtgacatg gtacacaccc attaggttga cttgaataat attttcccac tcatcagctg 1704601 acagatctaa gaaaccgcca aatttgctga tgccggcatt attaatgagg atatcgatat 1704661 caccgagctg ttccttcact tgagctacag cttggttaac ctgatcggca tcttttacat 1704721 ctgcagcagc aaatgcagct tttacaccaa gcgctttgac ttcttcagcc actttttcta 1704781 cattagcgga agtccggcca attaacccga tattcacgcc ttctttggca agcgccagag 1704841 cagtagcgcg gccaattcct ctgcctccgc ctgtgattag tgcagtttta tgttgtaaac 1704901 tttgcaattg aagcaccctt tctttgttta catatgtacg atatcacatt ataagtacaa 1704961 tacatccaat acgcaaatca aacgaactgt gtaaatatca tttcttctga ttaaaaaaac 1705021 ggatacaggg taatgacata agaaaaggag tgaacatatg attatagttt atatcagtct 1705081 tgcagtatta gcagtttcta ttatcttctt aggagttacc gtgatccaaa acaagaaaaa 1705141 aatagacccc gcactaaagg agctttcctc tgttacgcag gctatgcaaa aacaaatcga 1705201 aggattaaaa acagaaacag agctgctgac gcaaaaacaa aagaagattc agcaggatgt 1705261 ccaaataaaa aaatacacgc ttcagcagac cgcagctgaa gtgaaagaag ttccccaagc 1705321 agtcaaagag gtgtggcagg caggacattt taatagcaga taaggatgaa tgagatcccg 1705381 ttgttacgat cagaatggac aaatgggatc tcatttttcg aggaggctta cacatgatta 1705441 taaaccgcag ctgcttaaaa gagttcgcag aaaaagtaca ttttcttccc tcttcactta 1705501 caaagtccga tttacttact gatccatttc gtctccatca agaaaacgaa cttggcatct 1705561 actattcacc tcataatgaa tttatcaatc gggatgcctc gcttgtgatt gccgggatca 1705621 cgcctggttt ttcccagatg aagacagcgt acgaaacagc cgccgaaagc ctgctgcaag 1705681 gcgggactct tgagcaaatg gcagtagaca caaaaatagc agcgggtttc tccggatcga 1705741 tgagacataa ccttattacc atgctggatt tatgcgggct gccgcaagct tttggcattc 1705801 aaagcgccgc aaagcttttt ggagaattac ggcatatgct ccatacaact tccgttatta 1705861 aatatcctgt ctttatccag caaaaaaact ataccggata caaaccggct atcactcatt 1705921 ctcctatcct aagcacttat gcttttgggc acttccctgc agagcttaac catgtgacgg 1705981 gaccagctct tctcattccg ttaggaaaag cggccgaaac agtgtgtgaa acattgatca 1706041 gacagcacag cctccagaat ttgatttgcc ttaacggctt tccccatcca tcaggcgcga 1706101 acggccatcg tttgaaacaa ttcagcaaaa acaaagagca actagaaaga caaattcgtt 1706161 cctttgctgc attggttgat ttcgctatag aaaagaggaa ataaaaggga tatgataaac 1706221 aaaaacacaa acgtggggag tggttgaatg tttcctatat tagaaacgga tcggcttata 1706281 cttaggcaaa tcacagatca ggatgcggaa gccatttttg cttgtttctc aaacgatgag 1706341 gtgacacgct attatgggct tgaaaacatg gaatctatag aacaggccat ttcaatgatt 1706401 caaacgtttg ctgccctcta tcaagaaaaa cgcggtatac ggtggggaat tgaaagacgg 1706461 gacactaaag aactgatcgg aacaattggc tttcacgctc tggcccaaaa gcataggcgc 1706521 gcggaaatcg gttatgaaat catcccggag cattggcgaa acggatttgc atcagaagtc 1706581 atttcaaagg tcgtatctta cggattttct gcccttggac tgtcgcgtat tggcgcagtt 1706641 gtatttaccg ataatgaagc atcaaatcgt ctgcttctaa aaatggggtt tcaaaaagaa 1706701 ggcgttttaa gacagtacat gtatcaaaat gggactccat atgatacaaa tgtgtactct 1706761 attgtgaaac caagagaatg acggtattct cttggtctgt gccacatccc ttttccttta 1706821 aaaagataaa aagcgcccct caaacagggc gctttctaat taagatgcat attgaggaga 1706881 tgtttcctcc ttaactgctt tttcctcagg tatatgaata cattttgtca agaccgcact 1706941 tgcaaggtaa agggccgcaa agatccagac gacaccttgc gcgccgacga gaccgatgaa 1707001 cagccaagcg agtgcagggc cgacaaacgc tgataaacct gcagctaaat tcaatacaga 1707061 catggctgcc cctttatctt ttcctgccac cgtcggcaca attgcaccaa tcggcacata 1707121 gcctgccagc aaaccgcccc aaataaagcc gatcacgctg acaaccgcta aacttccgcc 1707181 ggagaaaaca ggtgcgtagt ataataagac ggtgaaaatg ccgcagccga ctccgccgaa 1707241 ccaaataaca gtatttttcc agccgaattt atcgccgaca ataccgaaga taaggttaaa 1707301 cacaatgttc cccaggaaaa tcgttcccca aatttgcagc cacacattgg ttgaaattcc 1707361 atgctgggcc atgtgcatcg gcaaaaagac tggaaaacca tatgtaccaa tgctgttgat 1707421 gattctgatg attccgcctg taagcacgcg cggatttgta aatagaatcg taaccccttt 1707481 taaaagctcc tcggctgttt ctgatctttt tcttttcttc ttttcaaaac ggtctttatt 1707541 gataaacaat gcaaagaatg caccgagaca tacccagaaa atagagctcc aaagcgtatt 1707601 caaataaccg aacgctttga tcgcgtagct tgagtaccaa gcgccgaaca caaacatgcc 1707661 gaggcaatat gcaatccaaa accagccgac agcagtgctc agtttgcttt gcggtgttct 1707721 gtaaatgacc catgtcaaga aagaataagc aaaaagcggg taacctaacc cttttacgaa 1707781 gtaagtcaca tacatcactg gcaggttcag ctgttcaaat ccaaatacga taaaagcagc 1707841 tgtaccgatc acataaaaca acagccccat aaacatcgtt cgttttgcgc caaatgcttc 1707901 gagacataca cccgaaaacc aggaagctat ggcaagcgca attccgtata tactaaaaat 1707961 ggaagcggac tgctgaacgg tgagcccgtt ttcgatcaaa aaaggactga gccagccttg 1708021 ttcaaggcca tctcccatca taaacaaaac aacccctaaa aatccccagg caagccgctt 1708081 cggtattcct attttatcca acatatctgt ctcctcctta gatgctatta ttcattaccg 1708141 tattacctta ttaaagttga aaattaaatg attcctcaaa acagcagaaa ttccgtctta 1708201 aattaatact ttgctttctg atcctgaaaa aaagcgctgt gtttgcttcc attcctcata 1708261 taaagccaat tctatctgac agtccttcgg ttcgatcacc cggacatttg ctgacatctc 1708321 ctccgttaat tgaaaggttt cattgcaaat gactgcagca ccgacgacag atgcctgatg 1708381 atatccctct tggacataga cctttttttg aagaagatcc gcgatatatt gagtgagcgc 1708441 tttgctttgg aatccccctc cgcacaccca aacataatca cgttcaaacg gagtaacctc 1708501 tgttaaaatg tcaaagttcc atttgattga aaatgcgatc tcttctagcg ctgcacgtac 1708561 aaaatgtgcc ctctttaaat gtgctgacag cggggcatca aaaagaaaac cgcctctcgt 1708621 taacgcattc ttttcagccg ataaataaga gccgagagcc gctacacatg catggtcttc 1708681 ttttgcaagt gcagaaatct cctcctccat tacttcgtac gtttcattcg gataaaaaat 1708741 ctgttttaat ttttgataat tcaagccggt aattcccgga ttcgtttcca caagccaatg 1708801 cccttgatcc gtatgacagt tcaaccaggc tttatgtttt gtgtcgccat gatcctcagt 1708861 aattttggtt attggcgttg ttgtccctga tacaatgaca atgtcctcaa gtccagctcc 1708921 ggtgcttttg acagccagct gtgtatcccc gccccctgct ataaccttag catttattga 1708981 aaggcctaat tcggatgcat attcatttgc tatcgttcca attgctgttc ccgctcttac 1709041 aagaggcgga aggatagatg gagaaaagcc gaaaatgtcg cacatctctt ctgaccaagt 1709101 gttttgcttc acatcaaata gcagggtttc tgttgcctgt gatggttcat atgttaatat 1709161 tccgctcagt tggtacgtca cccaatcact gatgcttgta aagcttgcag tcttttccca 1709221 taaagagggc tggcgctgtt ttaatccata aagcttgagc gcagaaaaaa gtgcagttgg 1709281 caggcggcct gtgctgctgt atatctcttc ccaatcggga atgcccgcct cccactctcg 1709341 gccgcgatta tcgatgttcg gcagcccgag aaaaggattg ccgttttgat caatcaaaac 1709401 aatcccctgt ctttggctcg tcgatgtcaa accaatgatg tcaatatcac acgaacggga 1709461 tagcgcacgt tttgccaaat tcatcacctg cttccacagc acctgaggag aaaaataacg 1709521 gctgtccggg taaagcgtct ctgtggaata ctcgatgtcc tcccgttcaa ctgttagaac 1709581 actgccagtt acactcacga ccgctaccct cgcattgcct gtgccaatat caaaaacgag 1709641 atagcctttt tgttttttca ttctgttagc ctcctttctt atccccctgt tttcagtgcg 1709701 tccttgttat acattgtctg aatattaaga gttttttcac ccttccactt tttgagggct 1709761 ttattcagta tcgtcacgtg atgatcctcc acttcaaatg ttgctccagc gagatgcggt 1709821 gttgccagaa cattaggcaa tgaaatcaat tcataatctg attcctctgg aggttcatga 1709881 taaaaaacgt ctagtatcgc accgctgatt ttatgttctt ttaatacaaa taaaagatct 1709941 tcacggttta caacaactgc tcttgaagta ttaacgaaaa tcgcactctc tttcatcaga 1710001 tcaaaatatt gccgatctat cagtccgagt gtttcctcag tgcgaggcag atggacagaa 1710061 acgatatcgc tgtctgaaaa caccgtttta agagatgctt tttcatacaa cggatgatcg 1710121 tcttgaatgt atggatcgta atattttatc ttacagtcaa acgcagtcag cagttttgca 1710181 atcctttgcc cgactgcgcc gaacccaatc atgccaaccg tttttcctgt tagctcattt 1710241 cctttaaatt tgacataagc ctgcaggtaa tcactgtccc actctccatc cttcagccac 1710301 tgattcgagg cgctggtatg gcgcagaaag gaaatcacat ttccaataaa catttcggca 1710361 acggcttgtg cattccgccc tggtgtataa aaaacaggta tgcccctttt tgaggcagct 1710421 gccacatcca catttgaggg cattcccctg caaacaccga caaatgaaag ttcgggaaca 1710481 gaagcaaata cgctgtctgt tacctgatca agttcagtaa tcaagcctgt cgcatttgtt 1710541 gcttttagca gctgaatgag ttcatcctcc cgatatgccc taccttgttc cttccaagat 1710601 tgataagcaa ctgagccaaa caagttttca agctcttttc gtccttcttc gttgtacggt 1710661 gctgtaacca aaaccgtcat gctgcaaaac atccttttca tcgtattttt cataaaaaaa 1710721 atctctttcc gaagatggaa agagattcat atataggcgc gctctgttac aggcagacgc 1710781 cggtataaac cttgctttcc tatctttcaa gctagcgctt gctggaattg gcacaataat 1710841 gttgccgagg tttcataggg ccagtccctc cacctctctg gatagaaaat attgagtatg 1710901 taattttcag aatgaagaat acgtttatca taaagaagac tcagattgat gtcaatctct 1710961 ttttttcaga attgacgtta tcatcggaaa tgttataatt cttacaaaat atctaactag 1711021 agagaggaac tgggccatga gatcttttgc cacacaacaa aacggcattt tcaaatccgt 1711081 ttgctcgctg gactgcccgg atcagtgcgg attgttaata cataaaaaag acgggaaaat 1711141 cgtaaaagtg caaggagacc ctgatcatcc tgtcacagct ggaaacatat gcaacaaagt 1711201 ccggaatatg acggagcgca tctatgatga aaagcggctg actacaccgc tcaaacgaac 1711261 aggtgcgaaa ggccaagcga tatttgaacc gatttcctgg aaagaggcaa tcgatacgat 1711321 cacctcccgc tggaaacagc tgattgatga agagggagct gaaagcatac ttccttacag 1711381 cttttacgga aatatgggga aattgacagc tgaaggaatg gaccgccgct ttttttaccg 1711441 catggggtca agccagcttg aacggacgat ttgcagcaaa gcgggatctg aaggctataa 1711501 atatacaatg ggcataagcg cgggaatcga tcctgaggaa accgttcata caaaactatt 1711561 tattttttgg ggaatcaacg cggtcagcac aaatatgcac caaattacga tcgcccaaaa 1711621 agcgcgaaaa aaaggtgcca aaattgtcgt gatcgatgtg cataaaaatc aaacaggacg 1711681 tcttgcagat tggtttatcc caataaaacc gggaaccgac agtgcacttg ctcttggcat 1711741 catgcacatt ttatttaaag aaaaccttca tgatgaagca tttctgtccg agtacacggt 1711801 tggctatgaa gagctccgtg aacacgtgaa acaatatgat cctgaaaagg tatcgacgat 1711861 caccggtgtc agtaccgaag atatttaccg actggcaaaa atgtacgggg aaacctcccc 1711921 ttcttttatc agaatcggaa acggacccca gcatcacgat aacgggggga tgattgtaag 1711981 gacgattgcc tgtcttccgg cgatcaccgg ccaatggctg cacacagggg gcggcgcaat 1712041 taagcataac agcggaattt tagaatataa cacaaatgcc ttgcagcggc ccgacttatt 1712101 gaaagggcgc accccgaggt cgtttaatat gaatcagctt ggcagggtgc ttttggaaac 1712161 agacccgccg attcgctctc tatttattta cggaacgaac cctgccgtcg tcgcgcccga 1712221 agcaaacaaa gtcagacagg gcttgctgcg ggaagacttg tttactgtgg ttcatgattt 1712281 gtttttaacg gaaacggctg catatgcgga cattgtactg cctgcaacat ccgcttttga 1712341 aaatactgat ttttacacct cctactggca ccattacatt cagcttcagc agccggtgat 1712401 tgagagatat ggggaaagca agtctaacac tgaggttttc cgattactgg ctgaagccat 1712461 gggattcaca gaccaggagc ttaaagattc agatgaagta ttaatccgcc aggcgcttga 1712521 ccatccagat aatccgcatt tggcagagat tgattacgat tcacttacta agcattcatt 1712581 tatgaaagcg aaacgtgaaa agccgctgtt tccgggcgaa cttccaacgc caagcggaaa 1712641 aatagaatta tattcagaaa aaatgaaaca agacggcttc cctgctttac cgacatatac 1712701 acctcttgta accgataatg aacatccgtt tatgtatgtt ccggggccaa accataattt 1712761 cttaaactca acattttcca ataatgaaaa acacatcaag cttgaaaaga cgccaaagct 1712821 ctttatcaac acaaaagatg ctgaaaaaca cggaatcgtt gatggggcac ctgtacgaat 1712881 ttggaacagc cggggagaat gcgagctgac cgctgcagtt ggagaacaag tgctgccagg 1712941 tgtcgttgtc agccaaggat tatgggcgga tgaacaagga aaaaaacagc ttgtaaacgc 1713001 gctaacccca gatcgcttgt ccgatatggg cggcggcgcc accttttttt caggccgtgt 1713061 acagattgaa aaggtttgaa aaataatgaa acccggagta tgccaagccc gtataacata 1713121 acatcgacat aatggaggca tacacatgga cgttttttta ggaattggta ttgctttggc 1713181 tggatatttt atcggtgaag gcttaaagca gaggaaccaa accaaaggta atgaacaaaa 1713241 tgatatcttc ctaataaaag aacgggatat ttacttttac attggacttt ttttaggaat 1713301 aacaacgact gaagcaaaac agttagctgg agacatggca gacctgcctt acatcgaaat 1713361 aaacggaaaa aaatatgtcc agaaacatat gttaaaagat tggacattca cattagttga 1713421 aaaacatcag ggtgaataaa acaaatctga ggagagcgag attcattgtc acgctctcct 1713481 ctgtttagct gtatggatcc tgccaccaaa actttgtgct ataagcgctg ataaaacgat 1713541 aaaccaccat ctatgttctt tcctcaaaca actcaagatg cccgttccac aacaatagtt 1713601 tttatattcc tttgatgacg tgatgttctt gatgaacgta tgtatcgtaa aacacttaga 1713661 aaacctattc ggtttgaatg tgtgctctca ttatgccccc atactgcgcc tttatccgcg 1713721 gaggattttt ttaaaaaaat atgaaaccta aagcttttag atcctgaatt tttattgaac 1713781 ctccatattt ctccgattgg taaaaattag cctatacacc ggaagctgta cgtttataaa 1713841 ggatcagaga atcccataac cagtaaatca ctgcagccgc aatacttaac atataataaa 1713901 agtacgattg caatgtccat gctattgacg caggttcatt gataacaaaa aacaggaaag 1713961 ctgcgataaa agcaaccaca ctgtaaatca ataggtacat gacattgaaa gttctcgctt 1714021 ttttctgcaa cttcatttgg agcggaacag caaaaaggcc atacaccaca aaaccgtata 1714081 ataaagcaat tgctgccgta aacaatgcaa ttatcatatc gccatacata acgaaagaat 1714141 aaaaccctaa taacaaacca aatgtaaggc tggatagccc taatgtcatt aaataatatg 1714201 atgcgatttt tttcattttt tcacccccct tgtttgattt attcacagtg ctgttagtat 1714261 aaattcacaa cctttgtatt tcttttatcg agatgtcttc cctaacgtgc tatacgcaat 1714321 gcgctaataa aaggtttcaa aaatgacgtt cttttattag ataatacgct ggctgaaaac 1714381 gcctctcctg attggccaaa gcgcgaatga aaaaagtgca tgaatacctg cccaacagac 1714441 agaataagaa gagttgatat ttcaacactt ttcgtaaagg ggtgaaacca atgagtaaga 1714501 aaggtattca aaattcaagt attgaacaaa taagaaatga ccatgagact gaaacagctt 1714561 ttaaagcaga tgatcctaaa aaacacggtt ccgatcctaa aagaacgaaa taagttctta 1714621 cccccactaa aatatcaata atctggagga agtaaagtga ctcaaaaaaa cggtgcagac 1714681 agacctgatg attataaaag attttcttca ttagacaagg aatatgattt tcagcaatct 1714741 atacgcagca atactgagac agaaagtgta aacactgaaa cacaaactca taacaaagaa 1714801 aacaaaaatg acacaacaga tgttgccggg aaatactttg agccctcaga ttataaagga 1714861 agcacgcaat tagaaaaagg attggctgaa actcatgaac aggtcagcga tgactatttt 1714921 gaagggacaa tcgatcaaaa tttggactag ccatacaaac ggaactaact taaaagaagt 1714981 cagttaactc tgtttttaga aacaaccaca gtaaaagtag ccaaccccca ccgaataaga 1715041 tgggggttgc acgtaagtag cctgtttaat atttaaaacg attaatgacg gtttgaagtt 1715101 cttctgccaa ctgagataga gattctgcgg cataggagat ttcccccatt gaatgaagct 1715161 gttcctgtga tgaatttgca accgcttctg tatttgctga cgtttctttt gtaccagcag 1715221 ccaatgtatg aactgtgtgc tgaatcactt caacgcctga agtaagctgt tgagttgctg 1715281 ctgcaacttc ttgtatttga gaagtgacct gttccaccag gttcagtatt tcattgaaat 1715341 ttcctgttgt ctcttgagaa agaacaatac ctgagctcac attttcttga acaactttaa 1715401 tattatttac cgtttctatc gattcgtttt ggatggtcgc taccaccgat tggatgtggt 1715461 ttgcagattt atttgtttca tccgccaact tccgaacttc ttctgccacc acagcaaatc 1715521 cttttccttg ctctccggct ctggccgcct cgatcgctgc atttagtgcc aacaaatttg 1715581 tctgctctga aatcgtcgtg ataagcgaag agatatcgct gatttctgct gtgctcgcta 1715641 ccaatgtttg caatccattg ccggctgaat ctacagattt atcaatgaat ttcatctggt 1715701 ctaacatctt gttgacggac ttagagccta tttcagcctt gtctctcatc gaagaagaaa 1715761 gatccgctat gttccctgta tttgaagcga ctgatgatat actgtctaat aattcagtga 1715821 tggattctgc gctcttttct gtcattgagc tttgcttcac attgctgtcg gcagccatct 1715881 gcatggctcg tgaaatatgt tcagatgttg atttcgattc ttccgcgctt gccgataatt 1715941 cttcagagga agcggcgact tgttcagatg agctgctgat ctgcttcaca atttgagtta 1716001 atgaatgagt aaaagaatta aaagattggg caagctggcc aaattcatct ttatttttca 1716061 caatgacttt tttggttaaa tcagcctcgc cgtgtgcaat ttcctccagc tgcttattta 1716121 tgcttcttag tggcaccata atggacttta acagcattat gcttagaaca atgcctaata 1716181 ttactgatat ccctgtgaca atgataatga gcgattgact cattttccca ttgccctgta 1716241 tttcatcctt tagatcctct acctcttgat ccaggcgatc agacagctta ttgacagccg 1716301 gagctacgcc ttcttttctt attgttcttt cttctccaaa atggatggtt tctgcttttt 1716361 taggatttga agagtaggct gttactactt gctgattcaa agctctatac tgagtaaaac 1716421 ttgtcttaat gtcttcaata ttggattgat acttctcttc atcaatcaag tcattaaccc 1716481 ggtcaaggct ctttaagaca tcgtctgctt ttcccttcat accctcgtcg tattctttgt 1716541 ctctggtaat caagaagcct ctttcatcat ttgataaccc ggtcaattca tattggatgt 1716601 gttttatctc tttttggaat tccattttgt ctttaagttc ttcattcttt ttcacagtag 1716661 aagaaatcat aaatactgag gagcctccaa ttccaataat tgaaacaact aatattgata 1716721 taatccccag caattttgtt ttcactttca tgtgtcgttt tccctttccg cacaatgtaa 1716781 tggctgaaat aaaatatgtt caagcgcgtt tgaatccaat tcgcttacgc tcatgtccat 1716841 aatatcgaca cgtgttatca agttttatag tgatattctt atatgaataa gcaaattctt 1716901 tacgtctctg aacttacaga aaaaccttaa gtaaaatttg cagtcttttg cggtatgtaa 1716961 gtcactctta ttcgtttttc taaaaaaggc ttttcccacc tcaaattggc tgaaccggct 1717021 gttttctcga aaatataata caatacgcag cataatatga aggagcgaaa cttaaatggg 1717081 gatcatcaat ggtaaagaat tcattgaccg attgaataaa ctagaaaacg aaatatggta 1717141 tgatggcgaa aaaataaagg gtaacatttc tgagcatcct gcatttaaag gaataatcaa 1717201 aacaaaaagc tcactttatg aattgcaaac aaaggatgag ttaatacatg aaatgactta 1717261 ttgccttcct ggagatcata atcgaatcgg cctttcctat ctccagccta aaacaaaaaa 1717321 tgatttgaaa aaaagaagga ccatgattga acattgggct agacatactc atggaatgat 1717381 ggggagaagt ccggattaca tgaatacggt tatgatgagc tttgcttcgt cagcggagct 1717441 tctaaaagat aaagagaatt gctttcctga acatatacta gatatgtatg aacaagctgc 1717501 taagcatgac ctttccttta cccatacatt cattactccg caagtgaacc ggtcacagtc 1717561 ctattttggg ctaagtgaaa aaccgatatc tgctaaagtc attgatagaa ccgaaaaagg 1717621 tttaatgatt catggcgcac gactgcttgc cacacaaggc gggttgaccg atgaaatctt 1717681 ggttttttca gcgcctaaat ttttctttga aacagatgaa gcttatgctt tttcaatccc 1717741 ttctaataca aaaggcgtaa aattcatcac aagagaatca tttgtattaa gcgactcttc 1717801 ctttaatcat cccttaagct caaggtatga agaaatggat tcaattgtgg tttttgatca 1717861 tgtgttagtg ccgtggaatc gtgtgttttt ttacgataat gtggaagcag ctaaagattt 1717921 tatgacaaaa agctcttttc atgcctttac ctttcaccag gttgtcatta ggcaaatgat 1717981 aaaaattgaa tttctattag gtgttgcaca gcttcttgtc gacaccatta atgtttccga 1718041 atatcagcac atccaagaaa agctctcaga aatcattgtg ggattggaaa caatcaaagc 1718101 cctcattgac aaatcggaaa atgatgctca gttagatgaa ttcggctata tgcgcccctg 1718161 tttaattcct cttcaagtca tcagtacgat cattcctaag ctatatcctc gatttactga 1718221 aatcatacaa ttaattggag ctagcggaat ggtgacactg cctaccgaaa atgcatttga 1718281 ctcagagata cgggaagatc ttgaccaata tcttcaagca accaatacaa atgctgaaga 1718341 acgtgtgaaa attttccgtt tggcatggga tttaacaatg agttcattcg gaactagaca 1718401 aactcactac gaaagatatt ttttcggaga tcctattcgg atttcaagca ggctgtatac 1718461 cagttatcca aagcaggagc agttgaacat gattaaaaca tttttacatg cagatacaga 1718521 acattgaaaa aacagcggga aaagatccgc tgtttcgtat tttttattca ggaaactgaa 1718581 catggcccgg tactgtatag gctttggacg ttccgctttc aggcagcttt ggaatggtgt 1718641 ctttcacaac ttttccgcgg atgtcagtca ttctgacttt gagagagcca gtacctaaat 1718701 tcgtactcac aaaatggtta tagtccattt tctccatgtt gatccactta ccatcctttt 1718761 catattccat tttcataaca ggatacttgt gatttctgac ttggattgct gcccaccacc 1718821 tgctgctgcc ttctttgatc cggtacgtga aattgccggt gattggggct ttgacaacac 1718881 gccatttaat attgattttt ccgtctttca tattgccgat tttacggaag gcattaggtg 1718941 acagatcaag agctccccga gcgccttcgg gataaagatc agtaacatat acggttgttt 1719001 tcccttttgg cccttcaact tccaaataag agccggcaag tgccgctttt actcctccgt 1719061 aattgagatc cgccggattt attgcagtaa tctccatatc ggaaggaatg ggatccagca 1719121 ggaaagctcc tcctgaatag cctgaccctg tatacgttgc ataaccttca tgcaggtcgt 1719181 catatgctgc cgaagcttgc ggggaaaaac agaagatcgt caacaaaacc ataccaacaa 1719241 atgcactcat gatctttttc atatttggtc ctcctcaaac cagacttcaa atgagaatca 1719301 ttatcattat aagactcaat ccatctggtt tgaaagagga aatagattca tagttgattt 1719361 taaggcaaat tcactatcat tcatatatca aatgtaggta cttatgaaaa agccaataca 1719421 aatgaacgaa tgtgcacttc agccgaatgt cttatttttc cctctcaaaa ttcgcatttc 1719481 aataacgaaa tgaaacaggc tgttggcctg ataacagcta tacaggaaaa gctatttttc 1719541 cccgctcagt ttcaacttag ctgtcatcat gatgccaaag atcagcacaa tcggaaccca 1719601 aataatgaag tgataaaaat caggctcagc cagagcaaca ataatagccc ctacacaata 1719661 caaaataata gccagtgctc ttaacacagt atctcttaag aaagtcttct tttgcttctt 1719721 aaaaaacaaa cggccggata tatcctctaa aagagaagcc aaagtgccgg tcaacacagt 1719781 tgaagaaata cctgcaatcc ccagtttttt tgctgctgta gtttgaatcc ccatagaaat 1719841 gctcatgagt ataattagaa tgtgcacagg aacaaatgcc cggtaaaaag aaagacaagc 1719901 aaagacaaac aaaatgaatg cttcaagtgc gagggctttt gtcacagcag aaggccaaag 1719961 ggtattttcc gcctttccga ccatcaatgt agcaatgatc acgccgcata taaatccgat 1720021 tagcgcagtc aaggaattaa aaacagtgac ctgaatggat ttgccgatag ctaaccccaa 1720081 taatacaatg tttccagtca tattagctgt gaacacatgt cccaggctta aatacccgat 1720141 tacatccacg attccagctg ttaaacataa aagtgatagc aaggtgtttc gataagctgc 1720201 tgcagtcaac ggtgtatcaa tcctttcttc tatttcaatt gttagtatgt cttttggcgc 1720261 aatctctatt ttttaagtaa cccaacatta attaggaaga tagaacctat tattcctttc 1720321 cattaactgt aataataatc cccgcaagga aatgattaaa attgaaagga agcatattgt 1720381 gatgaaacga ctttgtttat ggttcaccgt ctttagcttg tttttggttc tcttgcctgg 1720441 aaaagcatta ggtgcagtcg attttccgaa tacctcaaca aatggccttt taggttttgc 1720501 cggaaatgcc aaaaatgaaa aaggcatctc taaaacgggc acaacgggtg gaaaaaacgg 1720561 gcagattgtt tacattcaaa gcgtaaatga tttaaaaacc catctaggag gatccactcc 1720621 gaaaatttta gtgcttcaaa atgatctttc cgcatctgcg aaaacaacag ttaccattgg 1720681 ctcaaataaa acactcgtgg gctcttacgc gaaaaaaacg ctgaaaaata tttatttaac 1720741 aacttcatca gcttttggaa atgtcatttt tcaaaattta acgtttgaac acagtccgca 1720801 gattaacgga aataatgata tccagcttta tttagattcc ggtatgaact attggattga 1720861 tcacgtcaca ttctcaggtc atagctataa tgcaagcgga agcgatttgg acaaactcgt 1720921 gtatatcgga aaatccgcag attatatcac gatcagcaac tcaaaatttg cgaatcataa 1720981 atacggtttg attttaggat acccggatga ttctcagcat caatatgacg gctaccccca 1721041 catgacaatc gccaataatt attttgagaa cttgtatgtt agaggcccag gtctgatgag 1721101 atacggttac tttcatgtta aaaacaatta cagcaataat tttaaccagg cgattacaat 1721161 tgctacaaaa gcaaaaatat attccgaata taattacttt gggaaaggca gtgaaaaagg 1721221 cggcatcctt gacgacaagg gcactggtta tttcaaagac ataggcagct atccatcact 1721281 caacaagcaa acctctccgc tgacttcttg gaatcctggg tcaaactata gctatcgtgt 1721341 ccaaacgccg gaatatacaa aagaatttgt cacgaaatat gccggatcac aaagtacaac 1721401 tctggtattt ggctactgat ataaaagagg ccctgcgtta aaaacgctgt gcctcttttt 1721461 atactatagg ctatttttaa gcgatccttg taattccatc aagatccagc gtcggtcaaa 1721521 ctaaaaagca tatgttcttt tccacaataa cttcttaact ggctttctta ttataccagt 1721581 ttatcgcaag tgaaaagaaa tcattgttct gaacctgtat taaatgaacg atcgtcccac 1721641 aaactactta aaaaccccta aaaaggatga tggatatgtg cggcaggttt actttgtact 1721701 ctgcatttga tgatattatt gaccagtttg acatcgatca attttttcct aaaggtgaat 1721761 accagccaag ctataatgtc gcaccatcac aaaacatcct tgcaatcatc aatgatggat 1721821 caaataatcg cttaggcaag cttagatggg gacttattcc accttgggca aaagatgaaa 1721881 agatcggtta taaaatgatc aatgctcgag ccgaaacaat taccgagaaa ccggcctttc 1721941 gaagaccgct tgtcagcaaa cgctgcatca taccagcaga cagtttttat gaatggaaac 1722001 ggcttgattc caaaaccaaa atcccaatgc ggatcaaatt gaaatcatct gctctttttg 1722061 cgtttgctgg cttatatgaa aagtggagca cacatcaagg ataccctctt tatacctgca 1722121 ccatcataac aactgagcct aatgagttca tgaaagatat acacgaccga atgccggtta 1722181 tattggccca tgatcatgaa aaggagtggc ttaaccccaa aaatacaagc cctgattatc 1722241 tgcaaagttt gctgctgcct tatgatgctg atgacatgga agcataccag gtttcatcat 1722301 tagtaaattc acccaaaaat aattcagctg agcttcttga tgcagaaaat catatgtagt 1722361 gattgaaaaa attctctagc aagaacttgt caaatagctt tgttccttag gtgccaatcc 1722421 ctctagtaat tatgaatatt tagtacatag atcaattagt tatctttagc atcagtttga 1722481 aataatttta ttatgtaaac ttaaataagc aatgttattc ctttcatata aaatagttta 1722541 catttttata aaatcgcttc acttttctat tttgtcagca aaaaaactga accacattaa 1722601 acttatgaaa cctgccgcac ctgtggattg caaatatgat ataagcccat agaggtaaat 1722661 ccatacactt tccctcctaa gaattaaatg aaatttcttt catcttacat gaaggtcttc 1722721 tttcttttgt ttatccagtg taatacttaa taatatgttg atgaatgcag ctggaaaata 1722781 tataaatccc actccaagaa tgcctagtat cgtacttaaa cttactatgt aattctttgt 1722841 catcgtttga ctgtcaatca atattagaag tgaaatcaat ccagctaaaa cacctataaa 1722901 ccaagcatcg ccaacagcat aagaatcatc cagcatccct aaccatcgcc ccaatataga 1722961 gctcccaatg gcagtcaaac tggataaaaa tatgagtgct ttcatttctt ctcctccttt 1723021 aaagccaatc aaactggtag aaatcggcca ttgaatcccc attatcgaat ggttaccatt 1723081 tcatttccac attaacattt taaagctcat tacaatacga ttcaagcaga aaaaccctac 1723141 ataacgtata tatagggatt taataaaaca caggccaaaa ttcagctcta tctactttaa 1723201 aaagatatga agggcagctg tgtgatctgt tacgtcttta cgtaccggga tatttcacaa 1723261 caggcacttt cttcttgcgc agagaatcaa gcatgactga tccagcattc aagttgcttt 1723321 gtactaattc tttaggcgtc aatgccatcc actgattgag tgacacatct gcatagcggt 1723381 tacttttgaa catttctaaa aaccataatg tttctgtacc agtgttttgt atatagtgtc 1723441 cggcattaga aggcacgtat ccaacgtcgc ctgctctata atcaaatgtg cgggcagtcc 1723501 catttccgat aaataccgtc attcgtccct gtcctgttag ataatattgc cactcatcgc 1723561 tattgggatg ccaatgaagc tctctcatcg cgccaggctc aatctgaaca agtgcagcgg 1723621 ctatcgtttt tgaaattggg aagttagaag aatccacaat tcgtacactc ccccctggca 1723681 tttgaattgg gggttgattt aacagctcgt gtttaaaggt catggggact tttccatatg 1723741 gtgactgaat gtcttcactg gcgactgatc ccggcacatt cccttggtag atatagactt 1723801 gctcagacgg aagagagttg aaagcattct ccgggacacc gaaatttgca gacagaacat 1723861 cttttggtgt gtgtgcaagc caatctgaaa tggttaacgt tgaaaactca gaaaagttcc 1723921 catcatcgaa aacgagcaga aactcgcagt gttccaatcc ctgtatggaa tgcggaattc 1723981 ctgccgggaa gtaccaaagg tcgccgggac caacatcagc aatgaaattt cgtccgtctt 1724041 ggtcaacagc ggtgatacgt gcccgtccca aaagcatata agcccactcc gcttgcttat 1724101 gccaatgaag ctcgcggacg cctcccgcag ttaagctcat gtttacacct gcaatcgcag 1724161 tcgaaatcgg aagctgtctt acggtgattt ctcttgacca gccgccgtga tctaatttca 1724221 tgggagcgtc tgagaatgaa aatctcaagt taggaatcat accctcatct gtaacaggcg 1724281 gaacaaatat attcggattt tgaatatccc gtattatatt tcgcgggcct gtatcaatag 1724341 ctccagctcc atcacttcga ataggctgcg gcacgtttct gtcttcatga ttgattggtt 1724401 gttgttccaa cagcatgcac ctcgttttag aaatgaacaa gattttattt cagcctatgc 1724461 agaatcttag attgctgtgc ctaggaatcc gcaaataaaa aagtgaccac caatgtgatc 1724521 acaaatacat caaataaact attttttata ccatggcttc ttatgtaatt tgattgcttc 1724581 tgtctgtttt ttctggcctg tcctccactc cacttttact aatacatcat gacctatcac 1724641 ttcatcttca ggcatataat caaaggtgga aatatggtcc tccatgcgtc ccccacccgg 1724701 catttcatca cctgtgtact ccgataagtc gtactcatct acgttatcat cttgatactt 1724761 ttcgccatct acatacagag taattctttc aacaacagtc cacttttctt ccttcttact 1724821 cccctgccaa tatagattta gaaaataatt gggtccaatt gaagttttgt ctgatttttc 1724881 aaggttagac atccacagtc cgcttttccc gctgccctca tatttcactt tgttccctga 1724941 caccattaca aataatgtga tgatgcagat gatcaagaat ccagcaatga tcaatagcca 1725001 tttcttaata ttgttctttt ttctcatgtt tttcctcact ttcctaactt tttagtagga 1725061 aaatacgatc aaaatgttac cgaaaagaaa ataagaaagg gctaatgatc taacagatga 1725121 ctgtctaaac ttttgactta aattaaagtg ctttctaaag acaagattaa aacgtataac 1725181 agctcttaaa tgcatttttt gtttcattga gtcaagaacc ttaaaatggc tttttattat 1725241 taaaaatcaa gctagtgtat taagtaactt ttcaaattta tttatactca tgatctcgtg 1725301 agtcacaaat ctcccatcaa aaaaaacgct aaaagttgtc caaatagctg gtgacttttg 1725361 tgcctcttct ttcgatgata actgaattga ctgaaattga acccctttct tttcagtcaa 1725421 ttcccgcaaa tcatttatca tgcccactgc aaacggacac tgagctgtat agtatatcgt 1725481 aatccccttt tcattgatag aatcactttt cacctggctc ttaaatgcag gagaatctgc 1725541 aaggccattc caagtcaaag ccattaattg aaaataaggg gcagcttcat cttgtagagt 1725601 aaaccccata tgctcaaaga aatgcttatc acttaaatag ggcagttttt tcttgcctgc 1725661 gatatggata atgccatcca tgccgcacgc tttcgcatct gctatacatt tgtccaacaa 1725721 tcgtttcgca tgaccgttat ttttatatct gccagacacc cacagacaat taatgtacat 1725781 aaaattaggc gcattgatag gcacccatgc ctcattcgca ggtaggtatt caataaagac 1725841 ttttgcccgt tcatgtaagc gatagaacac caatccttca tccattcgag ctttgagcca 1725901 tctcttcttt tcattaactg catgctcata ttgtttcgtg cttaatgcac agcaaatatg 1725961 attgtcttca atattgtcct ttgtgatttc aatgtagcac atctcctctt tccccccttt 1726021 aacataatta catggaattc aacttcacac tttacatgcc taatagaata aatacccgtt 1726081 ccaacttaaa tactttttct tttccatttt gccaattaac tgtaaaaccc ttcttttatt 1726141 cagatattat cttgattcct atatcaccca tttcaaatcc aaagtgtgtt catctttgag 1726201 gattagatgc actgcttatg ctataaatac agtacacgaa gttttttatt tgaagtaata 1726261 tttgttacgg gacagcaata gtaaataagt gataaaaggg gaattaaact tggtggaaaa 1726321 atgttattct tgtttaattt gcggatacaa aggattaatt caaaatcctt tgtataaagg 1726381 cgagtatcaa aaaacgtttg acatttgtcc atgttgcggt tttgaatttg gctacagtga 1726441 ggatcatgat gtgaggttag gttttattgt aactcctgat catttaattg aggctgcatt 1726501 tcaattgtat cgcaaacaat ggcttgagag cgggatggta attgctcatc cggaagatat 1726561 tccagaagaa ttgaaaaatg gcaattgctt aaaatttgaa gttttgttga aacaattgaa 1726621 aaaactaaat cttgacatag aaaattttga aattagcggt ttttaatgat gaaacaggtt 1726681 gcacttgttt aggtttcact gtcattatca gtaaaatgtt aagttgaaat gcgcaatcag 1726741 tcacaaagtc tctattcgta ttcaataaag actttgtgat catcgacaaa catttcactc 1726801 ccatcggata aagtatccaa aaggcctcct ctggttcttc tctatagtca ttaatcacag 1726861 tcactttgac atttgactca gctatgattg gttttccaac aatttttcgt tttttcctca 1726921 ggcaaagtaa gagatcgaat catcaaagcc attccatctt tactgtctaa ttaacgccat 1726981 cttcagtgaa tttaaaggtc tgttttaaat tgcgtccttc ttgccccttc tgtgtccaaa 1727041 ttataacaac ctctaattca gaggccttat ctgccagcat aaaatgattg aacttcagcg 1727101 gtgagccatc atttaaactt tcagctaaca ttttagaatc ttcttttggt ttgacacaat 1727161 tttcatcggg acatccaaaa agcgaaaacc ttgtgattga attagggtca tttctataca 1727221 attgcacatc cactgtagct gctttttccc ctatattttt gacttccaag gaatatactt 1727281 gatattctcc tttatgaggt ctcgtaaatt cctttacatt ttttgcttca cttactttta 1727341 ctgaccactg gtctgttttt tgtgtaatag gcaacaccgt aaaagtcagg gcatgcgctt 1727401 ttgattggca aaacgtaaat ccaactgctg taaaaacaat tacagaaaat aatacccttt 1727461 tcacttcatt tatccctcct tcctttcact ggccgctcct taaagaattg attttgagca 1727521 atctacaagc tctcttaacc aaaaccttac ctgaggtttt gtctttactg ctctgcattt 1727581 atttctttcg gtatccgaga aggagctttg gggatttttc tcaatctgct gttaatcaca 1727641 tcagaagagt atagcgtaat aatcatactt cccccatacc tttttgcccg aattaagatt 1727701 ggttggttat attggttttg aaagcgaaag tcaggacctc cccagcttac cgtcgcatcc 1727761 cgtccgggcg gtacatatgg tacacttcta gtatgagaat agcgctgaac gatctgcagt 1727821 cctgcacgat ctactgcatt aaatagagtt gaggacacct gacaaattcc tcctcctaca 1727881 ccttcagaca actccccttt tacaataatg ggtgcacttt tatatccttt gttccgagtt 1727941 ctcattccca caacttggtt aaacgaaaac gtctcattag ggaaaacaac gtgattgtcg 1728001 attgcttttg cagaaagaga aatattgtgt gaacggcttt tattgcttga gttaaaatac 1728061 gtcacgtact gaccaagctg ctgcgtactg atgtgagcta gcagctcgct gtcaactttc 1728121 ggataaatgt tcatttccgg cacttctatc ttggagggac cttgcccata aaaatacgca 1728181 taaaactttt ccataaacgc ctgttgatac agtttgtagc caaccctgcc cgggacgatg 1728241 cttccatgat cgttaaggac agcatttatc ggctcacggt acactttctg atcaagctgt 1728301 ttgatgaatt tactgtattt ttcatagtca accattggag tgccgggaag aggcattgta 1728361 aagtcttcac ggttaacagt ggcaatcgtc cgtccttgct gtgtgaccgt taaactgtcc 1728421 tgcggctcac tcggctgagc caataaaaaa agaccagtga tcaaaatttg tatcataagt 1728481 cggtttacct cccaatcatt agtatgaaca gccgcttatc ctttgatgta tttcttccca 1728541 tcgtttgttt gaatctttag acgttgataa aaaccttcat aaaagagctt agctttatgt 1728601 tcacaccgat ccctgagctc actgaggcac acggttcatt cagtcggcaa gtttgaagta 1728661 gttcagcatc tcccagtgat gagggatgct tttttgtctt gtcaaaaatg aaaagggtct 1728721 cctataacaa caaaaaatca atccatttca atattttttt attgagaaac gataaatttt 1728781 ttgttacatt caattagaca acaaataaat gaggtgcttg ttatgaatcg aatgtcgaca 1728841 atttttttaa agatagcttt ggttcttatt ggaattccaa ttcttgcttt atgcattttt 1728901 ttagtgccta aggtagccaa ctattcagca gaattatttc caaatatcgc ttatataaaa 1728961 tatctcgttt tcatctattt gtatgtaacg gcgatacctt tttactttgc tctttatcaa 1729021 gcgttcaaac ttttaagcta tattgacaaa aacaaagctt tctcgggttt gtctgtaaga 1729081 gctttgaaga atataaaata ttgcgcagtc actatcagta tcttttacgc agcaggcatg 1729141 cctgtctttt atctgatggc cgagatagac gacgccccgg gtatcattgt gatcggattg 1729201 gttattattt ttgcttcaat ggtgattgcg gtctttgctg ctgttcttca aaaactgtta 1729261 aaagaagcga ttgatataaa atcagaaaat gacttaacgg tctgaggtga tgacatggcg 1729321 attattatca acattgatgt gatgcttgct aagaggaaaa tgagcgtaac agagctttca 1729381 gagagagttg gcatcaccat ggctaatctt tcgatattaa aaaacggaaa agcaaaggct 1729441 attcgattat caactttaga agcgatttgc aaggctttag aatgtcagcc cggggatata 1729501 ttggaatacc gaagtgatga agacacagga ttcgtaaaga aaaaatatga aggatcaaca 1729561 gaaaaataaa gtgattggcg gtgagcttat ggacataaac ttatatccat ctagctgcta 1729621 tactaagcgt ccctttcata cacgaagaac acaactatgg aggaggcata catcatgaga 1729681 gccataaaac aaatcgtcca ttttggctgg gaacaagccc tttcatgttt gtttcctgcc 1729741 gttatttttg cctctttggc tattacgcaa atcatcccac tgcccttctt gccgcggtat 1729801 gactggctgc tcattatctg cgttctcatg caattgtgga tggtgcgttc cggtcttgag 1729861 acacgggatg aattaaaagt gatcacatta ttccacctta ttgggcttgc tctggaactt 1729921 tttaaagtcc atatgggctc ctggtcttat ccagaagaag gatactccaa aatatttgga 1729981 gtacctttgt atagcggctt tatgtacgca agtgtagcca gttatttgtg ccaggcatgg 1730041 agaaggctta aggttgaact ggttaagtgg ccgtcttttt ttgcagttgt tccgcttgcc 1730101 gcagcgattt atttgaattt tttcacccac catttttcta tagacattcg atggtggtta 1730161 tcagggcttg tcatcattgt cttttggcaa acatgggtta catacgaggt gaatggagct 1730221 cgttaccgta tgccgctcgc actttctttt atactcatcg gattttttat atggatagcg 1730281 gaaaatatcg ctacgttttt tggagcttgg aaatatccaa accaaatcga tacatggagt 1730341 ctcgtacacc ttggaaaggt aagttcatgg ctcttgctag tgattgttag ctttcttata 1730401 gtagcatcat taaaacaagt taaggagcag agtcccacaa aggcagagat ggatgaatct 1730461 ttttcttagc atacgcatac aagctcccaa atagagtgaa aagcaacgtt caaatggttg 1730521 cttttttctt ttatgtaact ctgccggtga gtattcatct tcttcaaatt tcatcgcaac 1730581 acgataactg attcagatta caactgcttt caacactttg acaaactcat gcgccgccgg 1730641 cgttatctct tcaaatgaat gtgcgatgac gccaatatcg cgtgtgaccc taggaaagat 1730701 gtccttttta atcaattgat gcgggacgga tgaaagtgta aagtttgaaa tgatgccgat 1730761 acccaagtta tttttgacca tattaatcaa ggtttcggca ttttgcacag ttaagttttc 1730821 ctttaattcg atgttgtatt gcgaaaatgc gtttgacatc gcgatttcat gaccgccttt 1730881 acaaaaaatg aggtcatctt gatatgtttc aaggtcgaca tgcttttcaa gttttaattc 1730941 gtcacgctgc ggcgggatga cggccaccat atagtcgtta cacaatagct gattttcaaa 1731001 cggttcaaat ggagatgctg cgatcccgat atcaaccgtc cgatcttcaa cccatccttt 1731061 tatttggtca gaggttcctt cgatcaattc tatgcggatc agcgggtagt ttgatctgaa 1731121 tgccgcaatc gcctgtggca tgatatttgt tgaaactgca ggaaatgaac caattttcac 1731181 cttcccgttt aacagcttgt tttcccggtt ggctacttga tatattttgc tttcaattcc 1731241 cttcatttgc ctcgccagca gcaatatttc ttttccgatg tcagtcagca ttaaaccatg 1731301 atgtttatcc ctgatcaata atttgagctg cagtgagctc tccaggtttt ttatcgcttt 1731361 acttaccgcc ggctgagaga tgaacaattc ttttgccgct tctgtaatat ttaatttctc 1731421 cccaactttt acaaatatgt gaagatggtt catgttcata accatttggt tataccccca 1731481 ataataaaaa tgtatttcag ttatacataa atgtaacata tgatagaaac cagcacgata 1731541 ttttaacaag aaaggcggct tcattatggt aaaagttatg ctgggaatca tatctgtcac 1731601 acttatttgg ggttatactt gggttgcgat gaaagtagga attcatgaca tccccccgct 1731661 tttattttcg ggtttgcgcc tgttcatcgg agcagttcct ttatttctca ttctcttcat 1731721 ccaaagaaaa aagctttcaa ttcaaaaaga acatctcaaa agctatatca tcatgagcct 1731781 gttgatgggg ctgggctata tggggatttt gacgtatgga atgcagtttg tcgattcagg 1731841 gaaaacctct gttttggtat atacaatgcc tatatttgtt acggtgatca gccatttttc 1731901 attaaacgag aaaatgaatg tgtataaaac gatgggactg gtctgcggcc tcttcggact 1731961 gttatttata tttggaaagg aaatgctcaa tatcgatcaa agcgctttat ttggggagct 1732021 gtgcgtactt gtggcagcgc ttagctgggg aatcgcgaat gtgttcagca agctacaatt 1732081 caagcatatc gatattattc acatgaatgc ctggcacctt atgatgggag ccgtcatgtt 1732141 attggtgttt tcctttatat ttgaggcggt cccttcagcc gagtggacat atcaggcggt 1732201 gtggtcattg ctgtttaatg gcttgctttc caccggcttt acctttgtcg tatggttttg 1732261 ggtgctcaat caaatccaag cgtcaaaagc atccatggca ttaatgtttg ttcccgtatt 1732321 ggccctattc tttggatggc tgcaattgca cgaacagatc accatcaata ttatcctcgg 1732381 cgcactgctg atatgctgcg ggatttttat gaatacattt acattttcac gacggaaagt 1732441 gtgaatgata tacatttccc ctgtcatttg ggcttcatgt gacaggagaa gactattacg 1732501 agaaagtctt ctagaatcct gacgacagcc tattaaacaa tgaaaaaagc taatgtctgc 1732561 atgtagacat tagcttggct ggcgtttagg ctggtgagaa tccagatact tttttattac 1732621 cattctggct gatcaaactg aaaaccgtat agacctttta ctttaacatc tccgcaatct 1732681 ggatcttttg tcaaaatcaa ataatgagtc ttataaggca tcgtctcaac tcgatcagtt 1732741 gcactaaaat caaaatgatc ccccgagaag tttttttcac taacggttat ttcatatcct 1732801 gacaaagtca ttcgcatgat tcttgcgtta attgtacatc cttcagtatc gaaaatggtg 1732861 aatctgtacc caaagtgaga tgtccaatgg tttgaattta ggtcatcaga cttcataaac 1732921 catttttcat tctctgtcat tgtaaaactc actttctcct catctttcac gataacggcc 1732981 gaagcttccc ctacatggat agtcaaagcc aaaagaaatg taaaagctaa catcaacatc 1733041 tttttcaaaa gagttcctcc cgatatcttt tacttcaata tattggaagg gtcttttctg 1733101 atcaagacag tcttctccaa atgaatcttt agcaccatga aatgagcctt aataagaaca 1733161 gttttaaccc aaatcaacct ctattcgaaa taaggcttac caatctatat tctttttaaa 1733221 agtttctgca tttctttatt tagctcctag acacatataa aaaatgctcc tataagttca 1733281 ggagcactac aaaaaactgc taaagtgttt tctatcgatt tattgtattc attagctcaa 1733341 agaaatattc aggcttttga gtcttattta gcttatacca tgaacgcaat gtatctggtg 1733401 caaatacatc taattttttc aatacttcta ccgcaaattc cagaggagca attcctgatg 1733461 cagtaaccaa attttcatca gatactgcag gccccttttc atagaatgtt tctcctttgt 1733521 aattagggca gaccatattc atatagtcga ggtcattgct tgtgtgcttt ctcgaattta 1733581 agtatccttc attcgcgagg cccaaggttg ccccacaaat tgcagcaata gtcgtgccga 1733641 gctttaaagc gtcgccaact tttttcaaga tcggctgatg aatatcttct ccccaagtgt 1733701 ttcctccggg taaaatgata agatcttgac tcccaagagt acattcgtca agagaaatat 1733761 ctggttttat gcttaatcct cccaacgtag ttatcatttc tttattaacc cctactgtaa 1733821 ctacttttaa agatgctgca tcttgtttaa agtatctccc tgagtttagt tccgcaatta 1733881 aatatccata ttcccagtct gacattgtgt gaaatacgta gagataaact tttctcgttt 1733941 gcatccaata acactccaat cacaattgat aaagctttct aatagatgac tttgctgaca 1734001 gtcattgtca gcttttttgt tgattctatt cttatgccct tgttctccca acttataaaa 1734061 atataagatc aattgattct atgtttacta gcgcaaaggg gtttgttaca ctaactgtca 1734121 tgggaaacat ttcaaaggta atacaaaatc atttgaatga ggaggcctga tgaagttgaa 1734181 aactaaagcg tcaataaaat tcggaatatg tgttgggctt ttatgtttaa gcattactgg 1734241 tttcacacct tttttcaact caacacatgc cgaagcaaaa tccatagaag acacaaacat 1734301 ggcaagctgt ataacgaata aaaaatttgt tcaacttgag aaaaaatttg atgccaggct 1734361 tggtgtttat gcaattgata taggttcaaa caagacaatc gcctatcggc cgaatgaacg 1734421 atttgcttac gcatcaacct ataaagttct agccgcagct gctgtcctga agaaaaactc 1734481 aattgaaaaa cttaatgaag tcatccacta cagcaaggac gatcttgtta catattctcc 1734541 aatcacagag aaacacctag atacaggcat gagcctaaaa gaaatctcgg aagcggctat 1734601 ccgttacagc gataataccg ctgggaacat cttgttgcaa cagcttggcg gccctaaagg 1734661 ttttgaaaag tcactgaaac agattgggga tcatgtaacg aaagctaaac gattcgagac 1734721 ggatctaaac tctgcgattc ctggtgatat tcgtgacacc agcaccgcaa aagcactggc 1734781 aaccgatctt aaagccttca ctttagataa cactctcacg actgacaaac gcatgatctt 1734841 aaccgattgg atgcgaggca atgctactgg tgacgaactg attcgggcag gcgctccaat 1734901 aggatgggaa gtcggcgata aatccggagc cggaagttac gggacacgaa acgacattgc 1734961 tatcgtttgg ccgccaaaca gagctcctat tgttgtggca attctgtcaa accgctttac 1735021 gaaagatgct aattatgata atgctcttat cgctgaggct gcaaaagtcg tccttaacga 1735081 tctcaaataa tatgtttagc cttttgccac aaaggaaaag acattacttt tttaacttct 1735141 accgttcatt ttttgatgaa cggttctttc ataagacctc tagaatcata tatttaaaca 1735201 ccacaaaatt aaacattatt ataattaaca gcaagttttc attttatgga acaagtaaag 1735261 tttgaatctg acaagaatta agactaagca ccctaaaatc cgttttcttt tcttccaaga 1735321 atatactcct tagtgcaagc cattataaag atacaagtga acatacaatg cagacaactc 1735381 tcttaagtct cttattctgt gaccaatttg taatactcat gaatatccgg actcacttcc 1735441 aatatttcgt ctcgttcgaa gacactaaca tatcaaacca cttgaattaa cataactgaa 1735501 cttgatattg gtcactggca gtttcaatgc aatagaacaa catttgttgt ctcagaggtt 1735561 atctatatga gaattcaaca atttttttat aataattcat atttttgtat cgttgcactt 1735621 ggtggatttg actcttttcg tgtatggaac cacactttta ttttttcacc tcttttgaga 1735681 tcatctgtgt tatcaatctc acttaatcct acaattacta tgttattttt aaacttgttc 1735741 ataagttgtc cttcagaaag attgtaatct tcttttcctg gagcttttgt atcggtaatg 1735801 agaattgccc tttcattgtc tttaagcacg acatagccta ctaggctctg catctttgtt 1735861 tcgtctccgt tttgttcatt tttattgcag cctgcaagga aaataatgag cataatgagc 1735921 actatcaagc ttactccgat tttaggcatc tttcttcctc ctctttaaac tcatctttaa 1735981 aataaacaac aggatatcac ccaacccatc tacttctttt tgcaattcat aacagcagca 1736041 tactcattct ccaattcctc aaccttcttt ttattctttc tcaaatattt gcatgtggta 1736101 gccctcgata ttatccgctt actcattttt gcgctttcaa atatattatt gaaggccgct 1736161 tctttctgga ttccagcata aatatactta tccttactgt cgtttactat cgcaacttcc 1736221 attaaaatcg agatttttac tttttttatg atccattatt cacttccaaa ataacttcca 1736281 attacaacat aatatatgta taaattgtaa atggagttga tgtaattgaa gattaggaaa 1736341 atcttattga gttctgcttt atcctttggc atgctaatat ccgcggttcc cgcattggct 1736401 gctggcactt cgtctgaggt tgcagtaaaa aatgaagaat atgattatga cactatatac 1736461 cgcattagtc ctctgccaat ggacttccag ccaacaatag aatacaacgg ttatacttat 1736521 acgcttacac gtcattattt tgattactca atcgggtttt acacggctat ttatacaaaa 1736581 gttgtttaaa cttataaagg agctttttag ctcctttttc tcttgtttta agcaaggtat 1736641 ttctttctat gtggtcccct atcaaataca acatcaacat tctccagttc tctttgacac 1736701 gaacaaaatc taaagtttgg ttttaaatgc tggtaataaa aaattcactt taaagaagtg 1736761 ccgcccgcaa aatacggctt ttgtacacta cgccaatttt atattgaaaa gccagacctc 1736821 ctcaaagagg ttccagcttt tcttaatgtg ctatcgatct tcgttagttc aacgggaact 1736881 ttatcattcg gtacaaatgc agcctcccaa cttctagtta gggctgatgg cggaatatct 1736941 gacggttctc tacacacatc agacattaga agatttcaat gtagccttct gtaccatgaa 1737001 cgcgaattcg ttgcccatct tttatcagct tggcagcatt ttcaacgcca acaactgcag 1737061 gtaagccata ttcacgggct ataacagctc catgggtcat cagcccccca acttcggtga 1737121 ctaggccttt tatggataca aacaatggtg tccagcttgg atcggtaaag gaggtaacta 1737181 atatatctcc atcttctaaa tccgcatctt ccatgtttaa aatgacacgc gctcgcccct 1737241 ctataactcc ggaggaaaca ggtagaccta caatcgctcc ggctgggaga ttttctcgtt 1737301 tatactcacc tgtaacgatt tcaccatcag acgtgataac acgtggtgga gatagttttt 1737361 catataatgt gtactcgtct tttcgtgtac tgatgatttg ataatccagt ttatgtgtgc 1737421 gcacgacttc gtgaagttct tcaaaagtga gatagtatat atcttctttt tcatgaataa 1737481 cgcccgcttc tatgagttgt tcggcttctt tcagtaaagc ctgcttataa acgaagtatc 1737541 gattaaccat gccgtatttt ggatattccc taaacccgct gaaattccgg atgatatcta 1737601 tcgctcgttt tgtttctttg gctttttgtt caccatccgg taattgcttc aatcgatcta 1737661 ataactcttg ttctttcttc aaagcttcct gtcgcccttg ctcaaatttc cgatggccga 1737721 cattaggctc aaaattttta atattattaa gaatcattgg gacaagtgta gttggttttt 1737781 cgctccatcg agttcttgtg atatcaatct ctccggtaca tcgcattccg tatttgctga 1737841 gataatcata gatcgcgtct cgggttttgc ttccgccatc aaacttagcc agttcatcca 1737901 aaaagttatc atcttttaca tgttgtaagt aatcaattac ctctggataa ggacgaatca 1737961 catctgcgac gtctaatagc gcaagaccca tttctgaagt aatattatgg ggtacagatt 1738021 gagaaagcgt atctgctgcg tttttttcac ctaaccactc gttcattttt tcgttaatcc 1738081 ataatgaagc attcatagca gttcgaatta gaaccgaact ttttgggtta aataaaatct 1738141 tctttaattc ctgaatatct tccagaataa aacgaaataa atctgatcct gatttcgttt 1738201 ggatgttttg ttttaactct tctatcgatg tttgactgct ctcaatcaaa tcagacacga 1738261 ttgtcggatc gttttcaact tgagccggca tatctgcatt gcctctgctg ggatttggtg 1738321 ctgttttatc atttggtatc gactttatga aatctcgtcg ctttattatg gtcataagtg 1738381 cgtcttttaa gagctgatcg tgctgcccca tgccttttaa gaaaacttct ctgctgtcag 1738441 gggatgccag atgatgtgtg acatcaacaa atagccttcc accggcttta cgcatgggtg 1738501 caacagtcgt caacagaaaa aaagacaatc ccagtggttt tatgggatcc gtcatcattt 1738561 gttgatgacc aacagaaata tagacgtgat tttcttggtc actcgcttca gggatgggga 1738621 ataaagtagt gattggacga ctctgtacaa tataaaaagt atcgcgggcc aaacaccatt 1738681 cgatatcttg cggctggccg aaatgagctt cgatctgtct tccaatgcgt gccagctgta 1738741 aaatttgttc atcagtcagt gtttgagcct tttgctgatc agaatcgatc tgctgtgttt 1738801 ctgttccgcc ttcttttcgt ccgtagatag ccattttttt agttgctatt ctcttatcga 1738861 tgatttgccc atcctgtact ttaaaacaat cggcagatac caagccagaa accagtgctt 1738921 caccaagtcc aaaaccggca tcgatggata acacctttcg gttggaggta atcggatcag 1738981 cggtaaataa aatccccgaa gcctgaggga aaaccatcct ttgaacgata acggataaat 1739041 agacttggct gtggtcaaat ccattttgca tacggtaaat aaccgcgcga tccgtaaata 1739101 gggacgccca gcatttactg atatgctgca agattgcatc gacgccggta atatttaaat 1739161 aggtgtcttg ttgaccggca aaagaagcat gtggtaaatc ctcagcagtc gcactagaac 1739221 gcacggcata ggcatgttcc tcgccaaact gggagagata ttgagccact gctttcacaa 1739281 catcggaagg aatgtctact tccataatga tttgccgaat cttccggctg atgttaccaa 1739341 tctgatctcg gtcctcaact tttagcatgg tcaattgatc caacaacact tgtaacgttt 1739401 cgttttgttc gatggctttt tgatatccta ctgttgtgac acaaaatcct tctggtactt 1739461 gtataccttg aatttttgat aattccccta aatgtaaccc ttttcctcca acgagcgaaa 1739521 gctgtgtttt ttcaatttca tgtaaaccga gaaccaaaga actcattcta catctcccct 1739581 tcaaaaaaaa atattgacaa gagcttccta gcaggatata ataaaattat aagatggata 1739641 tctataactt tttaactaga aagcgcacgt agtgtgatta tatcaccgtg tctgtttttg 1739701 tgcaatataa aaagaacctg ggaaatttca ccaggttctt ttcttaattt ccatagctag 1739761 tcgcattaaa aaacttggtt tgagctgatt caatcctcta aggaaatcct aaagttgggt 1739821 tctttttgaa cttacttgct ttgttcgtag agtccccatt cataaattgg actttttgtt 1739881 cttaacagtc ccacctttaa ctagtataaa gttatgagga tctggttaac tactagatat 1739941 ttttattttg aataaggctt atgtttgata aagaagggtt atgtaaaggt gtctgttgtg 1740001 agcaagcgct gactacaaaa aattgatagc attctcattt aaataccatt ctattaacct 1740061 atagggaaag ttttaaaacc agatggagaa taccctacct ccagcaattc caaggccgtt 1740121 cacctagtag aaaacaacct ttaaccatta ctaacgattt taataatcat tgattataaa 1740181 acttctcaag gaacgatcag cagcccgtta gctacccctg attaaggatg atctgttacc 1740241 acactgttac gttagaactt ccactacttt gatatccttc tgtcgccatg acttggtaag 1740301 cccaattact gcccagattc attccatggc tcttccatgc gttcacatga ttgctgaaag 1740361 tgattgtagc gttgcttccg gttggtctct tcgactggcg aacactccag tactgcgtaa 1740421 aagtagtgcg atcgccatca atggaaggtg cgttataacg tgtagttgta tatatgtcat 1740481 atgtaccccc atcacttttt acagtacctt tatacgttcc agtaggtcta taagtacccc 1740541 atgaatccac tacataatat tctatgagag gtgatctcgt ccaaccatat aaagttaaat 1740601 atccattgcc attcggcgcc caaactccgg cattatagtt tatcgtccta aatggcgaac 1740661 ctgtagtcca acctttacca acaacaaaat ttccggtatt agaccaatta acactgtaat 1740721 tcccgccaga cccattgaca gcgtttacta taccgccccc atcagtccaa ttttgccagt 1740781 agtctgtgct agctgcagag gcggttgccg aaaacaagct aatactcatt aaagctgccg 1740841 ataatccaac taagaaattc tttttaaact taaacatatg ttacctccta taatattttt 1740901 tccgactttg aggtagcact cgtatacatt taaaacattc ttaattacta acgccaaagc 1740961 ttttgatcgt ccccttcagt ataataccac gaattcatga gcaaatatta aaagtatttg 1741021 taattcaatt acaaatacct agaaacacat tataagtggt cttcttccac catatcctga 1741081 tccgagctcg atgtacatgc ctttacggca cacacgaatg tggcgtgtgg tgcatcgcct 1741141 caatacgcaa agacgtttgc cttaggcaaa cgtctttttt tgcgttatcc gatttttgtg 1741201 ccgtttggga caggctgatc cggctgcaaa aggacgacgt cgccctggcc gggtatgccg 1741261 ccgaggacca agacttccga tttaaatccg gcgatccggc ggggcggaaa gttcacgact 1741321 gctatgactt gcttgttgat gagaccttcc ggcttgtaac gcttcgtgat ttgtgcgctc 1741381 gattgtttta tgccgatttc agtcccaaaa tctatcacaa gcttgattgc cggtactctt 1741441 gcttcaggaa attcttccgc ttttacaatt gttcccgttc tgatatccaa tttctcaaag 1741501 tcatcaataa ctgccatatc aataactcct ttttctccta ttgtaaagga gatatacaat 1741561 attcttttaa ctaaagagcc atcatttttt atccgaatat aaggtgtttc gatacaggcg 1741621 gggcggcatt cctgtgcttt tcgtgaacca tcttgtaaaa gaagaaaggt tttgaaagcc 1741681 cagcgcctcg ctcacgacgg taagagtttc atttctctcc atcagcattc tttttgcttc 1741741 ctcaaggcga aggtcggcaa tatagttctg cggggacttc cctgtctgtt ttttgaacca 1741801 gcttgaatag taagctgggt gataatgctc gatttctgcc agcttcttaa tcgtcagccg 1741861 ctcaaataaa tggctgtgaa tgtatgcaat tgaggcatag ctatgggatt gaagcttttc 1741921 ttttatgtat tgtactagca tatgaagcga gttggctgtt ccggcctttg cttcctctgt 1741981 cagcaagtac ctgatcgaag accagaaagg atcgagggca gcttcaattc ctgatcctgc 1742041 acgatactca tcaattttca ttgcatgaag cggaacatcc agtacaagac attcatttct 1742101 tccgatagaa cggaagcgat gctcgcactg cggcggaata tataaaaaat gatccggatt 1742161 taatttcacc tggcgcccct cagtctcaag atcaatactc ccttcaagcg gaaaaagaaa 1742221 ttggctgtac gcgtgcttat gtgaatgata tagccgtgtg tatgtccgtt tttcgcaaat 1742281 tatctcttga agcgagtcca ttagcaaacc ccttcctttg gtcatctttt aatccggtaa 1742341 tggtgttccg atataggcga aaagccgatt tttccatata aagaaactgc cgccagattt 1742401 tctttcatca cttgtaaaaa catgcgttcc gctccgttgt tttttgccca ttcagtcaac 1742461 accctgatca cttgggttcc tgcccctttt cctctgtgct cctcagctac aacgatatta 1742521 ctaagtccgc cataaccatc aatgacagaa accgtgccaa gcgctgtcag gctttctttg 1742581 tcatacatct tgaaaaaagt tttacacggc ggcatgcgtt cgaatatgtg tttgtaacct 1742641 ttgtgacgct cgggtgaaaa cccttctaat tgaataaatt catctatcca aacagatgat 1742701 ggctcttgtt cccacttgta tgtaaatcgg ctgttgtcat ttgttcggct cataattgac 1742761 cggcacaacg ctgtcatctg gaagcactcg tctacctttt cataacggct gtctgccaat 1742821 gcgtcatcaa gccctttcgg tgatgcgttg ctaatatgaa aacaaacagg taagcctaaa 1742881 ctttgataaa aaagttcggc ctctagctga aaatcccctt caggcatatc cgcagacgtc 1742941 catacgctat ttgccctttt ggttacgcca aaattcgctc tgagaagcca tttccctatg 1743001 cttttttgaa aataagccgg ccatgaagct gccgctaatc gttcaatctt gcgaatgtca 1743061 tccattgcat aatgcctctc ccctatgtat actcccttga tattatacaa tattcagaaa 1743121 tataagacat ccatttattt gtttacataa tatttttatt gtttattaat aatcctgaca 1743181 aaaatgtccg aattgaaaat gacaggcttt ctaaaatgtc ctcctcacgt tcaaatgctt 1743241 cttttgcgat taaaacagta aagccatgca gcagacttct gagccccctt gtcgcatgaa 1743301 tggcagtctt ttcacttgca tagccgtttt caatgagcag cttcgtcaca agacagacaa 1743361 tttggtcaga gacgatttcc gtccgtttgt cgtgaacctt aagaagagcc gcttcataat 1743421 atccgggatt ttcaattgca aaatcaacat atgcatgagc taaagaaagc atcgcggaat 1743481 ctccctttcg ttcggttacg gagtccgcca tttgatcaaa aagctttgtc agtcctctga 1743541 cagcaagttc tgctctgatc gcttgcagcc cgttgatatg gttatacaat gacggggggc 1743601 gaacattcat ttttttagaa agtgcagcaa gtgagacacc atttacccct tcctgatcgg 1743661 caatctctgc tgcagcgtct acaatcattt tttgggtcaa acctattctc ggtgacatgc 1743721 tcatcatcct ttctttgctt tttggatcgc ctgtctcatc cgctctgaag gtgatcgcag 1743781 gaattttcca tgtccgacag cgagacagga aggcgcctta tcggcgagca attgtgcact 1743841 tttgatggcc tcctccttat tccatgtggc gaaagcggga aaaggaaacg cccattttat 1743901 ctgacctgat acagcgattc ctccgcgcaa ctgaaacgca tctcctgcta ttaaagtgcc 1743961 gtttcttgta tcaagaaatg acatgctgcc cggtgtatgg cccggtgttg gaatggcaag 1744021 cagagaacca attgtttcac cgcccgtcag cagttggtga ggctttgttt gtatgtgttt 1744081 cggaatacct ccttttatag gcgtctgcgg ctcatcttgc cgcaaagatg tgtcaccttg 1744141 gagcaagaat gaatcccgtt ccgagatcat gacctttgca tgcggaaatg tttgtgccaa 1744201 tgtatccagt gatccgacat ggtccccatg tgcatgagtc agtaaaatat gctgaagcgg 1744261 ttttccaagc tgattcacag cttgaataat ccctttatag ctgcctggca gtgcggcatc 1744321 aataagggtg acttcgtttt cttcctctac taaatagcaa ttaaccggaa acaatgctgg 1744381 aaaaaaagtc agctgccaaa ccgtttggta ctgagtaatt ctcatctttt tattcctcct 1744441 aacaaaaact aatggtgtta gttttattat taactaacac cattagtttt tcaagagttt 1744501 attatttttt tatcgctaca taaatgttaa cttgtgctcg ctgtggcact gcggcatttt 1744561 gatcatacat ctcaaagtca cctgtaaacg tgcgcagatg ccgcttatcc caagtccaaa 1744621 tttccttcca cgtttcaagc acaatctctt caataggacc gattctggaa gtgaaaacgg 1744681 cgtaagcgga agccggcaaa tcaatatttt catatggtcc cggaagaatg tcgtcgtatt 1744741 cctgaaacgt tccgactgaa aacgtataaa acccattcgt ctcttgttca taattcgaat 1744801 ataaggcaat aatgctcttg tctttttcag cctgtgataa aagagcgctc atatcctgct 1744861 tccataattg atcccacagt gccggaatcc tcctttcttc cgtcatttcc agtgcgttgc 1744921 ttgtccgttg tgatagtccg gcaaatcgtt tcaggtctaa gtgtgttata tgtgaaaagc 1744981 ccatacgatc tcctcctttt tttaagatta tagacaaaga aacctgacag cagtgtgtca 1745041 ggtttcatat attttttgca tgtgatgaat ggtttctttt actttatccc ttatatgaag 1745101 aggctgcaga acctcaatat cctttccgaa ctggagcaaa aaaccgatca gccattgatc 1745161 ttctggaagt gaaatcaccg cctggcagat ttcatcttcc tcacaacagt gaaggacatc 1745221 atatccgaac cattcaccta tacgctgacg tgctgacggc tgaacaagaa taaccaattc 1745281 agttaaacgg tccttttggt accaactctt atcccatggc aaagtgtcca gctgaatgtc 1745341 ttttctgata aatgtctgat gtaagatggc cagatctttc atccggttca gtttaaaaaa 1745401 gcgaaaatca tttcttacca ggcagtaggc atataaatac cagtgccccg ccttgcaaac 1745461 caatgtataa ggttcagttt cccgaagtag tgtttccccg cttgcgcttg tatatgtaaa 1745521 agatatcgtt aacaaccgat cgatggcagc gctgattttc tcgcgcagcg tcttttgatc 1745581 ctcagtatgg ccccaagccg tcatgtcaat aaaccatttt tctgtttggt gcttaaatgc 1745641 ttgagtagat tgctcaggta taaggtgttt gattttttga taggctgtgc tgtgagaaac 1745701 gggttcatac atagatgaaa cgctttgcaa agcggaagca attgcaaaca attcctcctc 1745761 cttcagccac tctctttcaa gccgatacgt ttccatgatg ccaattccgc ccccggaacc 1745821 ctgtgaggtc acaatcggaa taccagccct attgatcgtc tcaatatcac ggtaaattgt 1745881 tctgacagat acttcaaaca gctcagcaag ctctgcagcc tgcacttgtt ttttgctgat 1745941 caataacaca accatcgcta acaaacgttc cagtttcatt ctgcgcacct tttcttcttg 1746001 tattttccaa caaaacaatc ataacatttt gataaagctt gggcatatct attatgcggc 1746061 ggaatacacc tcgcatatgc tatgaaaaca ggggtttccc cttctttttt gtgttcagta 1746121 tttatttcag ctactatttc cgaccggata agcatacact tctcaacgga ggggatttca 1746181 catcatgcat cttacacttc agagcgttta tcctgccata atcatcatct tttttctgta 1746241 taaaaaaatt aaaaggtcca tcggatacca gccgctgaag ccccgctggc tgttcacccg 1746301 tatcattctt ttctcgctgt ttgcttttgg actttcaatc ttcagcgcca ttcacccttt 1746361 tttatatgga tatctcattt tgggcattct tggcggatgg ctccttgtct ttttcgctaa 1746421 gaaaaacatc tcttttgaaa aacgcagagg aaagatctat tttcggactc atatttgggt 1746481 agaggtgatt ctcttaactt tatttctatc aagatttctg tatcgagtga cggagcttta 1746541 tcttacctca cctgatctaa accgccttgg atcatacagt cagtcaatcg gaacggaccc 1746601 tctgacaatt ggcgtctgtt ttctgatagc cgtttattat atcggttttt cttcttttat 1746661 catcaagctc agcagaaacg aacttgaaca gcacgaatac aataaagaaa aagacatcct 1746721 tgcccgctaa cagcgagtta agcaaggatg tctttttcaa tcatgctgtg tatgatggat 1746781 catttgctga agaacatcta aaacatgttc atcctccgga gagtaataaa tcgatgttcc 1746841 ttctctgcgc gatttgacaa gccggagatt ttttaaaaat ctaagctggt gggacacagt 1746901 ggattgcagt aaattcagct tttctgcaat tccgtttact gcatgctcac cttgggacaa 1746961 taaatggaga attctgattc gggtaggatc tgaaagcgct ttgaatgttt gcgcgactag 1747021 aaacagcgtc tcctcgtcca gatcagcagc cgattgttcc gtttctctaa attcagtcat 1747081 atgtatcacc tttctttatt catagtttta tcttataaca aatgcgcttg agtgcaaacc 1747141 agcctgcttg tattccattt caatctcata gtttaaattt atgtttcaaa tcaggttttt 1747201 acttggtctg atataccctc ttatgtcata ataaaaaagg tcatactgct ccaaacattg 1747261 agggtgaaac acagtgaaga aaaagagaaa aggctgtttc gctgctgcgg gttttatgat 1747321 gatttttgtc tttgtcatcg cctctttttt attggtcctg ctttttttca accgggattt 1747381 aatcaaaaaa cttccgatcg atacgaaaac gattgttttg gaacgtttaa ccgattacaa 1747441 acccttggtg gaagaagagc ttgaaagcca aggactctct aattatacat cactcatatt 1747501 aggcatgatg tatcaggagt caaaaggaaa aggcaatgat cccatgcagt cctctgaatc 1747561 tctggggtta aaacgcaatg agataacaga ccctcaactc agtgttaaac aaggcatcaa 1747621 gcaatttacc ctcatgtaca agaccggtaa ggaaaaaggc gtggatttgg ataccattat 1747681 tcaaagctac aacatggggg caggttacat tgattttgta gctgaacatg gaggaacgca 1747741 tactgaggaa ttggcaaaac aatactccga gcagcaagtc aaaaaaaatc ctgatctgta 1747801 tacttgcggg ggaaatgcga aaaatttccg ctatccgtat tgctacggtg attatacgta 1747861 tgcagaaaaa gtaaaagaaa aaacaaaaac tgttgaagaa tctttgcagg ttgcaacact 1747921 tgaaaccatg gaatccaagg ctcatgaata agagtctatc aatttactga caaaagccca 1747981 aaaatgaatt tgggcttttg ccatgtttac acgtaaaaaa agccatactg agtatggctt 1748041 ttaataatac ggtgaaatca tcaaatatac aataacgcct gtaaggctta catacagcca 1748101 tagaggcatt gtccatctcg caattttttt atggcgctcc acctgcatgc tgaagcctct 1748161 gatcagcgta aacagcgcaa gcggcacaat aattgcagaa aggcagatat gtgtaattaa 1748221 aataaagaaa taaatcgggc gcataatacc ttctccgcca tagagcgtgt tttccgcaat 1748281 cgagtggtac gtcacatagc aaatcaaaaa tagtaatgtt gttgtgaacg cagccaaaat 1748341 aaagcgtttg tgagctttga tatttttctg tttaatcata atcagcgcgg ccaataagaa 1748401 gataaacgta aagctattga atatcgcatt cagcattggc aaaatgtgaa tattcgcatg 1748461 gctgaactga tctaatttag gcataaaaaa cagcactgcg attaaaccgt taatcagaac 1748521 tgtcagcgta aggacaatcc ccgtgtaatt tttcggttta ttttctgttt ggttcatttg 1748581 gtgacctctc ctaatttgta ctggctatcc aaatcgtatg caaattcaaa gaagatgtca 1748641 acggtttcga ttgcttcgtc agaaattaga cacacttcaa aggccggagg ctattagccc 1748701 cggcctgtta ggtttacgcc tcttttatca aatgttcaat gaccttatgt tcattttcat 1748761 tcagcaggtt cttttgaatt ttcgaatgaa tgggtttatt catatgctga tccaagatat 1748821 cggccgtttc tttatccccg gcaataacca ttcgttccca tcttttcgcg gcagcttttt 1748881 gatcaaggct ggcagccagc cgcttataca gtctcgattg gttctctgtt acatgttccc 1748941 tcatccggtt ctcttcaaat ggtggcgctt tgtctacagc ggaatggcta ttcttccaag 1749001 actcattgat catatcatac tcataacgct ccaccgcctc aatttttcct aaaacagttt 1749061 caataatttt cacttcatgc tgctgagtta aaataaacgc cgtacttggg tatgtctggc 1749121 gcaaaccctt tagctgatcc aggacagctg tttcttccca gtaaaatctt gtatctacag 1749181 ggacttgaag cttaataggt tcccatatgc cgctgtcgga aacaaaaaac acgagactgc 1749241 ggggcatgtc ttttcccatt gcattcaagt attgattcat tttagccctg attccatcca 1749301 gacacttttc ctcctctgga tcactagctg ccaaatactc ttttaatcgg ctgaatcctg 1749361 actttagggc aatcttccat tctcccccct gctgctctgg atctctcatg tctgtattga 1749421 gatacagaga gagaatttta tccggcggtt ccaattggac atactgtaat ttgttaatca 1749481 atgaatcaat cgccattccg attcctcctt tttcacaggt tagttttctt tttcctctct 1749541 taaaaacgat caaacctgac tttccgctaa tttctagtaa taatggaatt gttgtttaca 1749601 atacgcctct cttctaatac aattggtaac tgtgtttcta agctgttttt tgaaaggagt 1749661 ttgatcttgt ttactgttaa agaaaaaaat cgtcaagagc ttgaggaaga actaaatgat 1749721 ttagaatttc aaatttatcg catgcaggag aatatgaagg atttatctaa agatgccaaa 1749781 gtgcttggta ttgatcaatc gaaacatgat gagtggatga ttgtttcctc gattgatgat 1749841 ggccaaacat gcaaaattat gctaactgat tgtaaaacgg cataccgagg aaaaggctgt 1749901 ttttcacttg tagcgtctta caaggacgat gccattcata taggggatat aaaaggccct 1749961 ccgaatcacg ggtttggctc catttgcatg aaatatttaa aagatattgc aagagaccat 1750021 aatataccga aagtcaccgg agacatcgcc aaacgggatt ggaatcatgt agaccggctg 1750081 attcactttt atgaaaaaca tcacttcaaa gtatgtatcg atcatgatac ccaatccggc 1750141 agcattaagt gggttgattt gtaaaaaagt ctggaagaaa gagccaagat atgctgtaat 1750201 ggtataaaac cattgatgga gggttctatg tacgcctcaa aactgaaaaa gggagacgaa 1750261 atccggatcg tgtctcccgc gaccagcatg tctatattat caaatgaagc aaaaatccaa 1750321 gcaaaaacgg cgttagaacg cttaggttat cgggtaacca tcgctgaaca cgcaaatgaa 1750381 tgtaacgaat ttgattcatc ctctatcgag tcaagagtcc atgatctgca cgctgccttt 1750441 tttgatccag gcgtcaaagc gattttaacg acactcggag ggtttaattc aaatcagctg 1750501 ctgcgttatc ttgattacga gaaaatcaaa cgacatccaa aaattctgtg cggttattcc 1750561 gatataaccg ctctttgcaa cgctatttat caaaaaacgg gtcttgttac gtattcaggt 1750621 ccccacttct caacatttgc aatgaaaaaa ggactcgatt atacagagga gtattttctt 1750681 tcttgctgcg cttcagacga tccgtttgaa attcacccct caagtgagtg gagcgatgat 1750741 cgctggtttt tggatcaaga aaacaggcgt ttttatccta ataacggccc tgttgtaatc 1750801 caagaaggtt atgcggaagg tactttaatt ggcggaaact tatgcacgct taatttgctg 1750861 cagggaacgg agtattttcc cgaaacagaa catactattt tattgattga agatgattat 1750921 atgtcagaca tccatatgtt tgaccgcgat ctgcaatcac tcatccacct ccccgctttt 1750981 tcacatgtaa aggcgatttt gatcggcaga tttcagaaag catcaaacgt atcaatagat 1751041 cttgtaaaag ccatgatcga aacaaaaaaa gaattatccg gcatcccgat catcgcaaat 1751101 ataaatgccg gacatacctc gccaattgcc acgttcccta taggaggaac atgcaggatt 1751161 gaagctattt cgggtacatc acgaatatgg attgataaac attaatcagc ttgtaaattt 1751221 ttttacaagc ttttttagcg caatcggcta tgcatgccgc acgagacatg acaaatgtca 1751281 tataggaggc atgatgtgtg ctactacaaa agacttctct cattagcgta tactgaaccg 1751341 agacacacaa tgagaggata cttactatga ctgaacaaac cattgcacat aaacaaaaac 1751401 agctgacaaa gcaagtcgct gcatttgctc agcctgaaac aaaaaacagc ctgattcagc 1751461 ttttaaacac gtttatccca ttcttcggcc tatggtttct tgcttatctc agcctcgatg 1751521 tctcctatct tcttacgtta gcattaacgg tgattgccgc aggttttctg acaagaattt 1751581 ttatcatctt ccatgactgc tgccatcaat cttttttcaa acaaaaacgc tataaccaca 1751641 ttctcggttt tctgacaggt gtcctgactt tattcccgta tcttcaatgg cagcacagcc 1751701 attcgattca tcatgcaact agcagcaatc tggataaacg cggaacagga gacatctgga 1751761 tgttaacagt aaacgaatat aaagctgcat ccagacgaac aaagcttgca tacagacttt 1751821 atagaaaccc gtttatcatg tttattctcg gaccgattta tgtttttctg atcacgaacc 1751881 gttttaacaa aaaaggcgca agacgcaagg aacgtgtaaa cacatacctt acgaatctgg 1751941 caattgtcgc gttggctgcc gcttgctgtc tgatctttgg ctggcaatcg tttttactgg 1752001 tgcaaggccc gatatttctg atttcaggtt caatcggtgt ttggctgttt tatgtgcagc 1752061 atacctttga agattcttat tttgaagcgg atgaaaactg gagctacgtt caggctgctg 1752121 ttgaaggcag ctcattttat aaactcccga aactgcttca atggctaaca ggcaatattg 1752181 gttaccacca cgttcatcat ttgagtccaa aggtgcctaa ctataagctt gaagttgctc 1752241 atgaacatca cgaaccatta aaaaacgtac cgacaatcac cttaaaaaca agcctgcaat 1752301 cacttgcgtt ccgtctatgg gatgaagata acaaacagtt tgtgtcattt cgggctataa 1752361 aacatatacc tgtaagcctt ccgcctgatt caccagaaaa acagaagctg cggaagaatg 1752421 cctgatgata aaggaggtct tctaatatac tagaaggctt cctttttatt gttggagggt 1752481 gcattctggc tttcacaatg ataaagttac aagtaagatg aaaagctgaa aatgaggtaa 1752541 gatcatgatt aaaaatcatt ttacatttca aaaactaaac gggattacgc cctatatatg 1752601 gacgatattt ttcatcctcc ccttctactt tatatggaaa tcatcatcta catttgttat 1752661 tattgtcggc atcattttga cgcttttatt tttttcggta tatcgatttg cttttgtctc 1752721 aaaaggctgg accatttatt tgtggggatt tttattaatt ggcatttcaa ccgcctccat 1752781 tactctgttc agttatattt attttgcttt ctttattgct tattttattg gaaacattaa 1752841 ggaacgcgtc ccttttcata ttttatatta tgtccattta ataagcgcgg ccgtcgcagc 1752901 caatttcagt ctcgtattaa aaaaggaatt ctttctgaca caaattcctt ttgtcgttat 1752961 taccctcatc agcgcaattt tattgccctt cagtataaaa agccgcaagg agcgcgaacg 1753021 acttgaagaa aagctcgagg atgcaaatga acggattgca gaactggtaa aattagaaga 1753081 acgtcagcga attgcccgcg atctccatga tacgcttggg caaaagcttt ctcttattgg 1753141 tttaaaaagc gacttagcaa gaaaattgat atacaaagat cccgaacaag cagctcgtga 1753201 actgaaaagt gttcagcaaa cagcgcgaac ttctttaaat gaagtaagaa aaatcgtttc 1753261 ctctatgaag ggcatccggc tcaaggatga attgatcaac atcaaacaaa ttctcgaagc 1753321 agctgacatt atgtttatct atgaagaaga gaaatggccc gagaatatct cattgctgaa 1753381 tgaaaacatt ttgagcatgt gcttaaagga agctgtcaca aatgtcgtca aacacagcca 1753441 ggctaaaact tgccgagttg acattcagca gctctggaag gaagttgtga ttacagtgtc 1753501 tgacgatgga acattcaaag gagaagaaaa ttccttttca aaaggacatg gcttactcgg 1753561 gatgagagaa cggcttgagt ttgcaaacgg aagccttcac atcgataccg aaaacgggac 1753621 caagcttacc atggcaattc ctaataattc aaaataaaca taaaggatgg cttatatgat 1753681 tagtatattt attgcagaag atcagcaaat gctgctgggc gctttaggat cacttctaaa 1753741 cctcgaagac gatatggaag tcgtaggcaa aggtacaacc ggccaagatg ctgttgattt 1753801 tgtcaaaaaa cgccagcctg atgtatgtat tatggacatt gaaatgcccg gaaaaacagg 1753861 gcttgaagct gctgaggagc taaaagatac aggctgcaaa attatcatct taaccacctt 1753921 cgccagaccc ggttactttc agagagctat taaagctggc gttaaaggct atttgttaaa 1753981 agacagtccg agtgaagagc tggccaacgc catccgtagc gtcatgaacg gaaaacgcat 1754041 ctatgcacct gaactgatgg aggacttata cagcgaagct aaccctctta cagatagaga 1754101 aaaagaagtg ctcgaacttg tggctgacgg taaaaacaca aaagaaatcg ctcaggaact 1754161 cagcatcaaa agcgggacgg tgcggaatta tatctcaatg attctagaaa agcttgaagt 1754221 gaaaaatcga attgaagcca ttacccggtc aaaagaaaaa ggctggttta aataaaaaag 1754281 gatcttggca tctgccagga tcctttttgt taacctgaaa ttcccgtttg agaacctcgt 1754341 cgcaaccaga attaaattga tccatatcct cgctcctacg cccgctgaac gattgtttgg 1754401 ttaacagccc aataaaagac tggattgaat gatatccctg ttaaaatggt cggccattgc 1754461 acatcagcag aatttctgat attgattata ttgtattttc agtatgacaa agttgtgcca 1754521 cttcgctccc gaagctgcca tgcccaactg caagagccta atatcacaat aaaaaaccgt 1754581 ctgaaatcaa tccgattccg taaatggtat ctgctacatc caactgctta ttatctgcca 1754641 aaaacaccag ctcgtttcgc tgatcaaaga tagtaacaac cagctataaa tgtcatgatg 1754701 ccgaatgtct ctgtaatgtg gaatcaatct tttaacccga gagcccctga atcgcacata 1754761 aagaaaaacg ggaccacttt cttttatcag catatgatat aaacagctct aagcagaaca 1754821 aaaaaagaca caagccaaaa gcttatgtct tttatcacaa tctatattat tagtttaaga 1754881 ctttaacact tacagttttg acgccccaat tagaagcatc acttttactt ggtacaaata 1754941 cgtcgatttt atttccttta atagcgccgc cagtgtctgc tgctgttgct tccccgtagc 1755001 cttcaacata gactttagaa cctagcggaa ttacattagg atcaaccgca ataactttcg 1755061 cgttcgggtt cttatttaag tcaatgcctg tagctgtaac gccggaaatg ccgccgtcgt 1755121 tagcagtgta agcagtagca gtaactgtta gttcttttga agcttcttga ttatttgtat 1755181 ttgattgaac agccttctcc tctgtgttaa cagaagtttc tgcctcagcc tttgtttctt 1755241 gtttaggttg ctgttgtaca gcttcttgtt taggttgctc tttttgcaca gcctcttgtt 1755301 ttggcgcagc ttgaggtgcg tttgtttgcg cattctcagt agctgtgttt gctgctgttg 1755361 cctgaccttt tactgaaaga gttgatccag catagatcat gtcagagctt aagttattcc 1755421 aaactttcag gttgttgact gtcgtgccga atttttgagc aatcttagaa agcgtatctc 1755481 ccgctttaat tgtatattgc ccagtcgtgg ttgtttcttc tgaagaaatg gtcagttttt 1755541 ctcctgcaat gattttatca gaagttaact tgttccattc ttttaagtcc tttaggttca 1755601 ctccattttt ctgagagatt ccccagagcg tatcaccctt ttgcaccgta atttcttttg 1755661 cagaagcgtg agctccgaat gcagttgttg aaagtgcagc aactgccaca aaggacataa 1755721 tcgtcttctt cataagtaaa tcctcccttg ttagcttttt attggcggct aacaggtgat 1755781 atcgtaacac acgtaaatgt caaatcaata acaaaaagat atgatttaga ttacagttcc 1755841 tttacatgaa ggatttctct ctgatggaaa gacttgctga acccttgata taataggctt 1755901 cgcaggtctt tttattttga ggcgaaacag agaaaataaa atgtgttttt tatagaaaaa 1755961 aagattgttt ttctgttttt ttagtctgtc atccttgcat aagcctgtat ttcttgtaaa 1756021 aaaagccggc cgtattttgc tcttttttgt tctccgactc cttttataga caaaagttca 1756081 tcatcattta cgggctgttt tcctgacatt tcttttaacg tttggtcaga gaaaacaaca 1756141 aatggcggaa caccctgctc agccgcaatt tctttccgaa ccatgcgcaa tcgttcaaat 1756201 agctcgtcat tttcagtaat cgctgccgct tttaacgctt cttttctcgc tactgataat 1756261 tctcctttca gcacattcct tcctttactg ctgacaaaaa gagtcggaaa cgttccgtct 1756321 gacatcctga tgaagtcgtc agaaataaga aattcgataa aatcactgat ttcgccaacg 1756381 gattggtgtt ttaatatccc gtatgttgaa aggtcggaaa agccgttttc aagaactttt 1756441 ttatttttgg agccggcaag cacctgggca accatcgtct tgccaaaccg ttctttcatg 1756501 cgaatgatac aagataagac catttgcgcc tcccgcgtca cgtcatgggc cgctcttgta 1756561 tcggtacagt ttccgcactg tccgcacgca tcaggctcct tttctccgaa atacataagg 1756621 ataaaacgct gcagacaatc ttccgtatga cagtagtcga ccatttgtct cagctttttt 1756681 aaatcctgct tttgtttctc ttcatgttct gattgctcaa ttaagaagcg ctgcaccata 1756741 atatcctgcg gtgaaaacag gagaacacat tcactggcaa gaccgtcccg tccagctcgt 1756801 cctgcctctt gataatagct ttccatatct ttcgggattt gtgcatgcag aacaaatctg 1756861 atatttgatt tatcaatacc cattccaaaa gcagaggttg ccaccatcac ttgaagctca 1756921 tcattaagaa atctttcctg ctgctctttt ctcacatcat cagccaaacc tccatgatac 1756981 cggcctgccc tgacctgatt tcgtttcaat ctctcatata tccgatcagc ttcttttctg 1757041 gtcgctgtat agacaattcc tgcttcatgc ctgttgtttt gcacatattc gtctataaac 1757101 cgatctttat tttctccttt tactacttta aaggttaaat tctctcggga aaatccggta 1757161 tataccgtgt tttctttttg aatatgcagc tgtttgcaaa tatcatcatg aacctcgggt 1757221 gtggctgttg ctgttaacgc catgatgaca ggcttgtcgt gtaattcacg gaacaagatt 1757281 tcaatattcc tgtagcttgg cctgaaatca tggccccatt gagaaataca atgcgcctcg 1757341 tctattgcga ccaaaggaac atctatgccc tgcaaaatcc ggataaactc tatggacgtt 1757401 agtcgctctg gtgtaatgta aaaaagctta taagcccctt ctttgagtcc gttcagcctc 1757461 tcatatattt cctgattgga ttgtgtgctg ttaatgtagg cggcgttaat ccccgcttct 1757521 tctaacgcat caacttgatc cttcatcaag gaaatcaacg gtgaaatgac gatcgtcgtc 1757581 ccttcaaaca ttaatgccgg aatctgatag caaatcgatt tgccgcctcc cgtcggcata 1757641 atgcaggccg tattttgcct cgcttccgtc accaagcgga tcgcttcatc ttggccgctc 1757701 cgaaacttct cataaccaaa ataatgagcc agaagggatt gggctctatg taacataacg 1757761 tgtaaacctc gcttttcctt gaatttctcc catcatatca taaaaaagcg gccttcattt 1757821 ctttcacaca aaaatggaat attcactata ccaaaccttt ttagataaaa taaaaagcca 1757881 tttccgaaaa ggaaatggct ttcgctacgt cttgccgtat gcaagtaaga aagttttaaa 1757941 ccaccactcc tcaaagtggg tgtttgcaga aacgttcctg tcgtcctctg caatggaggc 1758001 atgacattcc ggcttcgata taaaactccc tattacagct taaaggttaa aacttaatta 1758061 acaatacgca caaagtagct tctttaatat agtacaccat caggcgcttt taatcaagag 1758121 gtcagaacaa ttgtttagaa aaactttttc cagtgaataa aactgttttt tctccaaaat 1758181 acctgacaat tcgacaaaca aaaaatatat tacaataaaa aaaatagcct ttattgctaa 1758241 aagcgaatga ttattttctt ctatattaat gtgtatatac aaaaagactc ctatttgtaa 1758301 cgataggagt cttggcttta ttagaatttt gcagcaagat cttttgcttc ttgtaaacct 1758361 ttttcaacga tttcttgcgc ttgatcaggt gctgcgttat gtccttcgat gacaactgtg 1758421 tgcaagtctt gaacacccca gaaaccaaga actgttttca tgaagtttaa tgacatttca 1758481 agtgcagcca ttggtccttc tgagtagaca ccgccgcgag cgttaagaag cgcaactttt 1758541 ttgccgccca ttaaaccgac tggtccttct tgtgtgtatt tgaatgtaac gcctgcgcga 1758601 gacagataat caacataagt atgaagcact gctggcactg tgaagttcca aagcgggaat 1758661 gcgaaaacaa ctttgtcagc ttttacaaac tggttcagat atttgtcagc aattgctgct 1758721 tgttttttct catcttctgt catttccatt ccttgacctg ctttaaatgt tccgttaatc 1758781 atatctctgc caaggtaagg aaggttttcc ttatgaagat ctaattcaac cacttcatca 1758841 ttagggttgt tttctttata agcagctaag aaagcttcgt aaagtttagt tgaaacgcct 1758901 tcttcagctg tacggtcgct tgattttaca aataaaactg tagacatttg tattcctccc 1758961 ggtaaacttt ttatatttac ttacaaatag tatgttactt tcttttttac gtaaagtcaa 1759021 tcactttatt ttgaatatga gatttttttt caaaaaaaag caagtacatc taatatcggt 1759081 gtacttgctt ggcattttta cttcgaatct tgttcacgat ccaagatttc atacgtctgc 1759141 gagctttttt gatcaattgt ttctttgttg gataagtctt ttacctgttc atgaaactct 1759201 ctttcataag aaggagcatc tgtctccaga tcatcctcca catcagcttg ggcctcaact 1759261 gtcattcttg cataaggaac agcttcaagt ctttcgtaag gaatctcttg gccggttttt 1759321 tcacacacgc cataagttcc gtctttcatc ttttgtaatg cacggttgac ctcctctaac 1759381 agctcccggt caatctcttt cactgtttgg tctgtcatcc ggtctgtgac gagcgtcccg 1759441 tggtctgcca tatggttgtc aaccccattg gaaagctccc ccacttcttc cgtcattgat 1759501 tctgtttcct ttttctcgcc agacaattct ttttgcatat cgagcaattt atgatagaga 1759561 tgctgtgttt gttcttttgt cagtgccatg tatatcctct cctttctatc ctgtttcccg 1759621 ttttgccttc tgtcaaacat ggaaacatcg atggaaagat gagctactgc ctttttgaac 1759681 ggatcgtgac cgctggcgtc gatggtgctt cgggttttcg ttggcacttt ttgtccttct 1759741 cttctggcgg tatataatag gttgcgccta tatttaatct gccgctcagt tcatcaatgg 1759801 tcagctcgcc gaattcaaga tgatagtcaa ctttttcgac attcagcgtt tcaatatgta 1759861 tataggtttc ttcagactct tgtttgctgc tttgtttttg tttctcaatc actgagagtc 1759921 tttcttcaca ttcacgcagt ttgtcaagtt ctggtttcaa gcaatgcctg atcagcgacc 1759981 ggaacatttt tttcatgaca tcacgaccct ttgcatactc ctctttcgtc tacatatata 1760041 atgaggtata tcccatagaa aggagaggtt ttcatgcttc cgactaacat caatatttct 1760101 catctcaaga ctaactcgat aggcaccggc tcatccctta cctttggttc tgcggagtta 1760161 aggaacaggt gctctgctat caaaagaaat aacggttttg gggaacaaaa tgcagatggt 1760221 attgttatgg tcattccgat tgaatcaatt gatgaccgtg atgtgtcaga tgcactcagt 1760281 atgaaaatca atcatcaata acaatggttt tcgcttgacc ttcgtctttt tgaatagtga 1760341 tgtataggat tccgtcttta aaaatggcat tcatctttcc atgaagatga tcggaaagcg 1760401 gaattttctt ttcaaaactt ccgtatttcc cttctttttg gcgaaagtcc tgttcattaa 1760461 aataggaaaa gcgctgcccc ttcaccacta aataatctcc gtacgataat atgtgaacgt 1760521 cttgtttacg gtagcctgga agataaatta aaaactgcac ttccgcaacg gtatctacaa 1760581 tatccatgct cggaaatgaa gcatctcctt tccctcgctg atcttgctgc gcaaacggaa 1760641 acggagattg gccatttgtc ataaaagggg ttttttggtc ttcatcaaat acctgtttcc 1760701 aaaagtcacc gccgtacatc tgctgtgcga attccatcca ctgcttcatc ttttcgaaat 1760761 ccatttgaag ccccctgtct taacatactt tataaccgcc agcatacaac tatagaaagg 1760821 aggtttgcct gtggttcaac caactccgta tatcaatatt aatattttca tgctgaaaat 1760881 taattccttt gaaaatgctt cagcggttaa cgtaggacaa aatttattgg cagaatggca 1760941 aaattcagat aaaaaaaatc aaggctacgg acagaatttt ggagatgcga gcggatttat 1761001 gggcacgaga agccatgtgg atgacagaga ccaaattgat tctccggcct cttttgaaag 1761061 tgaagcggtt aactcctcaa tcaaaaggaa gtgatgagat gttcttttca ccctccgtcg 1761121 taaatgtcgg cggatttaaa atcaatacga tggatcgagg ttcctcttta acactcggtc 1761181 cgtatcagca ggtcgattac tttttatcag ctaaaataaa tcaagggttt ggagaagaaa 1761241 atggcgactt tactcctctt gtcgtgccga tttcaaatgt attagatgca gatcttgttg 1761301 attcgaactc agcgaaaaac agtgtggtgt aataagaaca gggcgcacat gccctgttct 1761361 tgtttttata tataaaaaaa gcctaaccat tttttgaacg gctggctcat caaatattca 1761421 gctgcacaaa tgctttgtca gcaccgcctg aacctcgctt aaatcggtgt ctttcgcaaa 1761481 ttctaattcg aaagttttgc ttcttgtcat caataaaagc ccagtgtccg gatcaaacat 1761541 tcccgcttct tggatggcaa agctttcaat tgttttatat ggaagaaata cacgaacctt 1761601 ctttttagaa aacattttat tgtcaaagaa aatgatccgc ttatttgtaa agcaaatttg 1761661 gtccactcgg agcttataaa tcgattcaat tctttcccct tcaacgagca aagcctcaag 1761721 cttctttgcg tccgttgatc tgctaacaga aaaaataccc aatgaagaac ccctctttct 1761781 gcatttatct atttgtttta tcattcacta cataaaaata agtcctttat ccctatataa 1761841 gaatacgaca tagaagacat ttaaaccatt acgaacagat tacatttttc aaatttttga 1761901 tttgtttttt ggcttttaag ctgttgtcat caagtaatac gcacatatag agaaaaaagt 1761961 ttcaatattc agcaatgttt ttataaaaaa gtggttttta atgatttttt taattttgtt 1762021 ttatatttcc tgttttaacc acaaaaaaac cgcagctgag ctgcggtttt atgtatcgac 1762081 tgcttttaac aaaatctgtt tgatgcttca aggaagcatt acatctcttc gaagtattct 1762141 ttataatagc cgccgacttt attcgtattg tcgaccacaa agagaaactc ctctgtttca 1762201 ttttttactt catattcttt tcccggcgtt aaaacgcggt ttacgatata tttttttgcg 1762261 tttgtctgca cacactttac ttttttaatg gtttcttttt caagccaatt tttatgaatc 1762321 atgatgaaat ctccttttct tatctataag cttattgtag cttttttctt ttgtaaattg 1762381 caatatcggt tattcattga ttttgccttg atttctatta tagaatgttt gtatacgctt 1762441 acgtttgaag caactatcac agcttatttc tgctattcaa tccaggaatc aatgtgctat 1762501 caccaagaat ctcagaacag accataaaaa atgactggag gtttgttacg gatgagttct 1762561 ttaacgatgc aagtgacgaa aaggctggag acatttttac agggaacaaa gaagctttat 1762621 attgacggaa agtttgttcc gagtgcctca ggggcaacct ttgacactcc aaacccggcg 1762681 accggcgaaa ccttgatgac gctgtatgaa gcccaggctg cggatgtgga caaagctgtt 1762741 aaagctgccc ggaaagcctt tgaccaaggt gaatggagaa caatgtctcc agcttcgaga 1762801 agcagactga tgtataagct ggcagactta atggaagagc ataaaactga gcttgctcag 1762861 cttgaaacac ttgataatgg gaaaccgatc aatgaaacga ctaatggaga tattccgctg 1762921 gctattgagc atatgcgcta ttacgccggc tggtgtacaa aaataacagg acagacgatt 1762981 ccggtttccg gcgcttattt taattatacg cgtcatgagc ctgtcggtgt cgtcggccag 1763041 atcattccat ggaatttccc gctcctgatg gcgatgtgga aaatgggcgc ggcacttgca 1763101 acaggctgta caatcgtcct caaaccggct gaacaaacac cgctttcagc tctttatttg 1763161 gcagaattaa ttgaccaagc cggtttccct gccggtgtaa tcaacatcat cccaggattc 1763221 ggtgaagatg cgggagaagc gctgacgaac cacgaagcgg ttgataaaat tgcctttacc 1763281 ggttccactg aaatcggaaa gaaaatcatg tccaccgcag cgaaaagcat taagcgtgtg 1763341 acattggagc tgggcggaaa atcgcctaat attcttctgc cggatgcgaa tttaaaaaaa 1763401 gccatcccgg gcgctttaaa cggtgtgatg tttaaccagg gccaagtctg ctgtgcgggc 1763461 tcacgtgtct tcattcataa agaccaatat gatgaagttg ttgatgaaat ggcatcctat 1763521 gctgagtcac tccgccaagg agcgggactt cataaagata ctcaaatcgg gcctctcgta 1763581 agcaaggaac agcatgagcg cgttctttcc tatattcaaa aaggaaaaga tgaaggagca 1763641 aaagcagtga ccggcggaag ctgtcctttt gaagcaggat attttgtcgc accgactgtg 1763701 tttgcgaatg ttgaagacga aatgaccatc gcaaaagaag aaattttcgg acccgtgctg 1763761 actgcaattc cgtacgaaac agtcgatgaa gttattgaac gggcaaacca ttcagaatat 1763821 gggcttgcag ccggactatg gacagagaac gtcaagcagg ctcactatat cgcggaccga 1763881 cttcaagccg gaaccgtttg ggtcaactgc tataatgtgt ttgacgcggc gtctccattt 1763941 ggcggttata aacagtcagg actcggacga gaaatgggat catatgcctt ggataattac 1764001 acagaagtca aaagtgtatg ggtaaacctt gaagactaac atgtatgttt aaaaaactgc 1764061 tgcctgccag cagttttttt ctttctgtaa tggcagtaaa agacgctgaa tatatatgct 1764121 tctgaaggag ttgagcgtga tgggcacact tcaggagaaa gtgaggcgtt ttcaaaagaa 1764181 aaccattacc gagttaagag acaggcaaaa tgctgatggt tcatggacat tttgctttga 1764241 aggaccaatc atgacaaatt ccttttttat tttgctcctt acctcactag atgaaggcga 1764301 aaatgaaaaa gaactgatat catcccttgc agccggcatt catgcaaaac agcagccaga 1764361 cggcacattt atcaactatc ccgatgaaac gcgcggaaat ctaacggcta ccgtccaagg 1764421 atatgtcggg atgctggctt caggatgttt tcacagaact gagccgcaca tgaagaaagc 1764481 tgaacaattt atcatctcac atggcggttt gagacatgtt cattttatga caaaatggat 1764541 gcttgccgcg aacgggcttt atccttggcc tgctttgtat ttaccattat cactcatggc 1764601 gctcccccca acattgccga ttcatttcta tcagttcagc tcatatgccc gtattcattt 1764661 tgctcctatg gctgtaacac tcaatcagcg atttgtcctt attaaccgca atatttcatc 1764721 tcttcaccat ctcgatccgc acatgacaaa aaatcctttc acttggcttc ggtctgatgc 1764781 tttcgaagaa agagatctca cgtctatttt gttacattgg aaacgcgttt ttcatgcacc 1764841 atttgctttt cagcagctgg gcctacagac agctaaaacg tatatgctgg accggattga 1764901 aaaagatgga acattataca gctatgcgag cgcaaccata tatatggttt acagccttct 1764961 gtcacttggt gtgtcacgct attctcctat tatcaggagg gcgattaccg gcattaaatc 1765021 actggtgact aaatgcaacg ggattcctta tctggaaaac tctacttcaa ctgtttggga 1765081 tacagcttta ataagctatg cccttcaaaa aaatggtgtg accgaaacgg atggctctgt 1765141 tacaaaagca gccgactttt tgctagaacg ccagcatacc aaaatagcag attggtctgt 1765201 caaaaatcca aattcagttc ctggcggctg ggggttttca aacattaata caaataaccc 1765261 tgactgtgac gacactacag ccgttttaaa ggcgattccc cgcaatcatt ctcctgcagc 1765321 atgggagcgg ggggtatctt ggcttttatc gatgcaaaac aatgacggcg gattttctgc 1765381 tttcgaaaaa aatgtgaacc atccactgat ccgccttctg ccgcttgaat ccgccgagga 1765441 cgctgcagtt gacccttcaa ccgccgacct caccggacgt gtactgcact ttttaggcga 1765501 gaaagttggc ttcacagaaa aacatcaaca tattcaacgc gcagtgaagt ggcttttcga 1765561 acatcaggaa caaaatgggt cttggtacgg cagatggggt gtttgctaca tttacggcac 1765621 ttgggctgct cttactggta tgcatgcatg cggggttgac cgaaagcatc ccggtataca 1765681 aaaggctctg cgttggctca aatccataca aaatgatgac ggaagctggg gagaatcctg 1765741 caaaagcgcc gaaatcaaaa catatgtacc gcttcataga ggaaccattg tacaaacggc 1765801 ctgggcttta gacgctttgc tcacatatga aaattccgaa catccgtctg ttgtgaaagg 1765861 catgcaatac cttaccgaca gcagttcgca tagcgccgat agcctcgcgt atccagcagg 1765921 gatcggattg ccgaagcaat tttatattcg ctatcacagt tatccatatg tattctcttt 1765981 gctggctgtc gggaagtatt tagattctat tgaaaaggag acagcaaatg aaacgtgaat 1766041 cttatcaagc ggagatgttc aattggtgtg aagccctgaa agatcagatt caaaagcgag 1766101 gtcagcttga ccagtttgaa gatcaaatcg acaagatgat tgaggctctg gaagatgacc 1766161 aaacaacaga agaagattgg tataaacagg ccgctgccct ttatcgggat attacagaat 1766221 cagatgatac aagtgaaaga cgcgcttatg tccctatagg gaaacacgtg ctgccaaagc 1766281 ttccttacaa atactccgcc ttagaacctt atatatcacg cgatattatg atccttcatc 1766341 atacaaaaca tcatcaaagc tatgtcgatg gcctgaacaa agcagaatca gagcttaaaa 1766401 aagcgagagc gacaaagaat tatgacttaa tcactcattg ggaaagagag cttgcgttcc 1766461 atggagcagg ccattatttg catagtattt tttggttttc tatgcatcca aacggaaaac 1766521 ggcgtcctac aggggcattg ttccaaatga tagacctttc atttggaagc tattccgctt 1766581 ttaaagaaca ttttacccag gcctctaaaa aagtggaagg cgtcggctgg gccattctgg 1766641 tctgggcacc tcgatcagga cggctggaga ttttaacggc agaaaaacac cagctcttta 1766701 gccaatggga tgtgatcccc cttttaccgc ttgacgtatg ggagcatgcc tactatttgc 1766761 aatacaaaaa tgaccgggcc agctatgtcg atcactggtg gaatgtcgtg gattggcgcg 1766821 aggctgaaaa acgttttgag caggcaaaag aagtcgtttg gaagctctat taaaaaaagc 1766881 cccctttcct cgggggcttc gtgtgttaaa aaatacctat cacatgcaaa aacacgatga 1766941 tgatggcaac aggagataga tatcgaatga gcagcagcca aaccgcaaac cactttcgtt 1767001 tgagattgga accgcttttc agctcgtcaa acaaatcctg tttcggtatt tttagcggaa 1767061 caaaaatcga aatcagtaac gcacctaacg gcattaaaat attgctcaca agatagtcag 1767121 ccgcatcaaa aatagacaga tgaaatatag tgacgtcact taagacaccg tatgataatg 1767181 cagacggcac accgacaata aaaatagcaa taccgcctaa ccaagcgaat cgttttctct 1767241 tattgatatc gcctttcgac agtactgcga ccaaaatttc cagcattgaa aaagcagatg 1767301 tcaatgcagc aaataaaaat agaagtaaaa atgctaataa aaagataatt ccgaacggca 1767361 tttgattaaa cacagtcggc agaacgttaa ataacagaac cgggccttgg tctggcttga 1767421 ggccgaatga aaatacagct ggaaaaatcg caattccggc cattacagca acaagcatgt 1767481 tcataacagt tacagataca gcggactgta ccagattttc ctgtttctct aaataagcgc 1767541 tatacgttac catgacagat acaccgacac ttaataagaa aaaggattgt cccattgcat 1767601 ataaaatggt attggcatca attgcagtta aatcaggcat gaggaaaaat ttgattcctt 1767661 ccatcgcgcc atcaagtgta accgaacgca ccattaaaat gatgaataat agaaaaagcg 1767721 ccggcattaa tacttggctt gctttttcaa ttccgctgct tacccctttt gcaacaacta 1767781 aaattgttac caccataaag agcagctggc ctcctacagc caaataagga tttgaaatgg 1767841 tacttgcaaa tatcgtatca aaaccagatg tttgcgataa accgccagtg aagcctttta 1767901 taatataaat taaaatccat ccgcctacga cactgtagaa agatagaaga ataaagcacg 1767961 tcaccatgcc taaataaccg atccaatgcc acttcgttcc tggagcaagt gttttatagg 1768021 actgaacggc atctttctgt gttcttctgc ctatgatgaa ttcacctaac aataaaggca 1768081 gtccgattaa aaccgtaaat aaaataaaaa taagtaaaaa tgcgcctcct ccgctggttc 1768141 cggcaacata tgggaatttc catatcgcac caagcccgat agctgatcct gccgcggcta 1768201 aaataaagcc gagcttcgaa gaccattgat ttgcttcctt caccgtatca ctcctatttg 1768261 atctaaccat tataaaggtt cattgtaaga atatcttcct atatagtcaa gaacatttta 1768321 attagtttac atcatatatc tatagacatc tgccaaaaac taatattgaa ttattcagaa 1768381 aattatttat aataagagaa tgttatgaaa tttgtaagaa tttctgctga agttcttgat 1768441 aagtgtgtta ggagtgtttt tatggacatc attagaaaaa taagccattt tgcaggacaa 1768501 acctttggca tatgggtcat tgtttttgca gtgctgggat tttctttccc atctttattt 1768561 acgtggatca gttcttatat tacgattttt ctcggcatta tcatgtttgg gatgggcctt 1768621 acactgcaag ccgatgattt caaagagctg gtcagaaagc cttggcaagt tattattgga 1768681 gtaatagctc agtatacgat catgccgctc gttgctttcg gcctcgcatt tgggcttcat 1768741 cttccagctg aaatcgcagt tggtgttatt cttgtcggct gctgtcccgg gggaactgca 1768801 tctaatgtta tgacattctt agcaaaagga aatactgccc tttctgttgc ggttacgaca 1768861 atttctacct tattggcacc tgttgtaaca ccgttgttga ttatgctgtt tgccaaagaa 1768921 tggcttcctg tctcgccggg gtctttgttt atctcaatct tacaggcggt tttatttccg 1768981 atcattgcag gtctgattgt caaaatgttt ttcagaaaac aagtggcaaa agccgtacat 1769041 gcccttccgc ttgtttctgt cattggcatc gttgcgattg tctcagctgt cgtcagcggc 1769101 aatcgggaaa atctgcttca atcggggttg ctcatttttt cagttgttat cctgcataac 1769161 ggtatcggtt atttactggg gtttctttgt gcaaagcttt taaaaatgga ttacccgtct 1769221 caaaaagcga ttgcaatcga agtcggcatg caaaactccg ggcttggggc tgcacttgcc 1769281 acggctcatt tctcaccgct atctgccgta ccaagcgcaa tattcagtgt gtggcataac 1769341 ctttcaggtt ctatgcttgc aacatattgg tcaaaaaaag tgaaaaagaa gcaagctgga 1769401 tccaaaagca gcaatctatc actttaaata tgcatcaaaa agggtacatc actttatcgt 1769461 gatgtaccct tttttattat ccttctaata aaagctgttc aggatcttcc agtaaatttt 1769521 tgattgtcac gaggaaacca accgcttctt taccgtctac aattcggtga tcataagata 1769581 aagcgatata catcatcgga cggttttcga aacgctcttc atcaatggct acagggcgca 1769641 gctgaatctt atgcatgccc agtataccga cttgcgggct gtttaaaatt ggagttgaca 1769701 tcaatgaacc gaaagtccct ccgtttgtaa tcgtgaagga gcctccctga agctcgctaa 1769761 gggttaattt attgtttctt gcttttttcg caagctcgcc gatctctttt tcgattcctg 1769821 caaatgtcag gcgatccgca tcccgtacaa ccggaacgac aagaccttca tcagcagcaa 1769881 cagcgattcc gatatcgtag aattttttaa cgatcaactc atcgccttga atttctgcat 1769941 tcaacagcgg atattttttc aatgcagcca cgaccgcttt cgtgaagaaa gacataaagc 1770001 cgagcttcac ttcattttgc tcaaaaaatt gatctttgcg gcgttttctg agattcatga 1770061 cagccgtcat gtccacttca ttaaatgtag tcagcatcgc tgatgtttgc tgtacctcta 1770121 caaggcgttt tgcaatcgtt tgtctgcggc gtgacatttt ttgcacttca acaggtttgt 1770181 caaagctttg ctgtgctttt tgagcctgag gctgctgctt ttgctgagga gccggttttg 1770241 atgccggttt ttcgtacgct tcgacatcct gcttgcgcac tcttccaagc ggatctccag 1770301 ttggaacttg agacaggtca attccttttt ctctcgcaag cttacgggcc gacggagaag 1770361 cgatcgttct tgattttgct tcagattgtg cttcctcgct cacctcttgt gcagctggtt 1770421 cagcctgttt ctcttctttt acgctttcct tgctttctgt tttctctgta ggagcagggg 1770481 cagaactttc acccgcgcct tctgaaatcg taccgataat ttctccgacc tggacggtat 1770541 cacccgaatc tttcaatacc tcttgaagta cacccgattc ttctgctgtc aattcaacat 1770601 tcactttatc cgtttctagt tcaagcagat attcaccctg ttctacatag tcaccaggct 1770661 gctttaacca ttgggctatt gttccttctg agattgattc tgctaattca ggtaccttaa 1770721 tttccgccat tttttcattt cccccttagt ttttgcgagt caagctatca gatacaatac 1770781 gttcctgttc ttttttatga actgtcggat ctccctctgc agggctggat cgtcttcttc 1770841 gtccaatata ttgaacgctt actccctctg gtgcaatctc tgtcaaatac gggctgatat 1770901 aaccccaagc ccccatgttc tgcggctctt cctgcaccca aacgatttct ttcaggttcg 1770961 gaagttttgc aaataattct ttgactcctt ttgccgggaa tggatacagc tgttcgattc 1771021 tcgcaatgtg aagccactct ttaccgtctt ctaacttatt aaaatgatcg ctaatgtcta 1771081 tagacacttt accgctggat aatacaagtc tggttacttt ttcatagtca tgagaaagtc 1771141 ccgactgttc ataaacaggc tggaagcggc tttcgctgag ctcctgcact tccgacaccg 1771201 tatttgggtt gcgaagaagg ctcttcggcg tcataatgac gagcggtctg atttcttcac 1771261 gaagcagcat tttagcctgt cttcttaaaa tatggaaata ctgtgccgcg cttgtcaggt 1771321 tggcaaccgt ccagttgttt tccgctgcaa gctgcaggaa tcgctcaatt cttccgcttg 1771381 agtgctcagg cccctgtccc tcgtaaccgt gcgggagcag catgactaat ccggattttt 1771441 ggccccattt cgcgcgtccg gcagaaataa attggtcaaa atacacttga gcagcgttgg 1771501 caaaatctcc gtactgtgct tcccacaaaa caagcgtttc cggtgaatgc acgttatagc 1771561 cgtattcaaa accgagaacc gatccttcag acagcgggct gttatgaaca gcaaatgatg 1771621 tgctgcagtc agataagtga tgaagcggca caaattcttt gcccgtctca ctgtcatgaa 1771681 gcacaaggtt tctttgggcg aacgttccgc gctcggaatc ctgtcctgtt aaacgaatcg 1771741 gtgttccgtc tttcaaaatt gaagcaaacg cgagtgattc tgccaaagac cattccactt 1771801 ttctgtcatc atcgaacgcc ttggcgcgtc tttctaaaat gcgctttagc ttgccgaaaa 1771861 cattaaatga ctccggccag ttgatcaatt cgccattcag cttgcggagc acatcaaaat 1771921 caatcgaagt gtccacatct gggaaaccgt ttgatacagg ctctggaagt tcaatttcac 1771981 aagcagtgtg ttccttttta gacggaactt tctgatatgc atcctcaatg cgcttcgtta 1772041 ccgatttttc gatgttttga acgacttcct cggtaaccac gccttctttt accagctttt 1772101 cagcgaaaat ttgtttgacg gtcggatgct ttctgacagc atcatacagc attggctgag 1772161 tggttgacgg ttcatccatt tcgttgtgtc catagcgtct gtacccgatc aaatcaatca 1772221 gaaaatcctt gttgaatgtt tttcggtatt cgaccgcaaa cttaacagct gaaagacaag 1772281 cttcaggatc gtccgcattc acgtgaacaa tcggaatttc ataacccttg gccaggtcgc 1772341 tggcatattt tgtcgatctg gattcagcgc tttctgttgt gaatccgatc atgttattgg 1772401 cgataatatg aatcgcaccg cctacttgat acccttttaa agagcttaaa ttcaatgttt 1772461 cagctacaat tccttcccca gggaatgcag cgtctccatg gattaaaatg gccagcgatt 1772521 ttgtttcatc ttgtaccggg tatccgcttt gtgttcgcgt ttcctgtgcc gctcttgtgc 1772581 tgccttcaac aatcggattg ataaattcca agtggctcgg gttgttcgct aacgtaatgc 1772641 gcgctgattt tgtttcagcg tcttgaagct cccgattcgc ccccaaatgg tatttgacat 1772701 cccccgtcca tccgtagctg attccaatgg atccctcaga cggtacaaga tctttgttcg 1772761 gcgcatgctg gaattcagag aagatgattt catacggttt gccgagcaca tgtgccaaga 1772821 cattcaggcg tcccctgtgc gccatcccga tgttgacact tgtcgtgcct gatttgacag 1772881 attgtgcaat aatgtcatca agcactggaa caagagcgtc cagaccctca atggaaaagc 1772941 gcttctgccc gacgaatgtg cggtgcaaaa actgctcaaa gccctctact tctgtcaatc 1773001 tttccagcac agctgacagc ttttcagctg agttcttctg gaacagctcg ccagattcaa 1773061 tctttcttgt cagccactcg cgctctttga agtcatgcac atggtcaaat tcaaaagaga 1773121 tggttctttt atacgtattt cgtaaatact gaatggcttc taaaccgttc gaaatgtttt 1773181 taggagcgtc tttgcagatg acagacgcag gtattgcttt tatttcctct tctgttagcc 1773241 cgtaatcgga taatggaaaa agttcgctct ttttctcatc ctttctgagc ggattgacgg 1773301 aagcgttcaa atggccatag gttcggatat cttctgcaag tctgactgcg gatgcgatct 1773361 tttgaatcag atcggctgta acacgtccct tttcttttgt tcccgaggcc tcttttatat 1773421 cgcttggcgg agcaccgagc tcgtcgaaca tttccttcaa atccgggtca atgctgttcg 1773481 gatcctgggt atactgatcg taaagctcca gcgcatagcc gaggttcgga ccgtaaaaat 1773541 cttcccaatt cattcgttgt ttcatactat tttgaaacat ttgaatatta cccccaactt 1773601 aaataatcaa gtgattgatt cactatcttg aaataacttt cgaacgctgt gtccaaaatt 1773661 atgtaataaa aacgcttcca acgatatttt accactgttt gcaatttgat tctaccttga 1773721 ttgttcacaa aatagtaaaa aacctttata aaaaacaaaa aatttaatca ttcgaaaaaa 1773781 caaacgccaa aaagcatagg attaagggct atcctatgct tttatgaagc agttttttca 1773841 gcagcggata caaaacatcc ggtagctgat caacatccgg gacaaatata ctgaattttc 1773901 cgtacatatc ctggatcgtc ttcatttgcg attcttctat ttctgagttg gagagaaaaa 1773961 catttatcac ttctattcct ctttttcggg cttcgataac cgcctcactt gtatcaacga 1774021 tcccattttg ttcgtagcca aatgcggccg gctctccatc tgagaaaaca attaagaact 1774081 tttgcgcctc gctgcgatgc agcatttttt tcgtcatctg cctaattgcg tacccgtcac 1774141 ggttatcttc ttctggctca agctgcataa tggccggtcc agaatcttgt cttaatgatg 1774201 attggaaggg aataaccgta ttgaaatagt ttggctggct tttttcggtt gcatcatttg 1774261 tgtcctccca aaaaccgaca atctgatgcg gaaccgctac cgatttcaac gcttcgtgaa 1774321 acagcacgat tcctcgtttt gtttcgtcca ttttgtcgaa catgctggcg gaacaatcga 1774381 ccagcaatgt aaaaactgcg tcgatttctg aagatggttc ttgctttttg tagaacaggc 1774441 gcggatttcg ctcagtgaag taacgaagaa gcttattgtt cagtctcccg gcatgaaggt 1774501 ctgttctcgg caatgttttt ttatgctcca gcgttttttg aatcatttgt ttcaaacgct 1774561 tttgatacga ttcaatcgtt tttgcctgct gtttataaga aagctcttct tcactggttg 1774621 ccggctgcgg ttctttataa attggaaatg catatttatt ttctttgccg tcagccatac 1774681 ccgctccgtt cggctggtct ttttgggact ccagcgcttc cagcttggaa tagtctttcc 1774741 gtttcgtttg tctggctgat ccttgaacag agccaagggc ctgatctcca tcgtcgcctt 1774801 cccttgaagc atcttttcct aaatctgatt ttgcgccgtg ttcaatatca aattgaagga 1774861 agcttttaga cggtgcttct gtttcccggt gccatgtcgg catttcttct tcatggatat 1774921 cctcatcacc gtctgattgt tttggaagcg tgatgtcatc actcagcttc ggcgcttttt 1774981 tctcttcttc aaataacggc tgttctgcag cttttgcgta atcaagctca ggcaaaaaga 1775041 agtaggtgtt caacatgtct ttatcgagta cctcttcaag tccgtccatg aggtcctcaa 1775101 caattttcag aacctgccgt gtcgaatctg cttcatacac acgcaagagc tgctgctcaa 1775161 taaacgggcg catcagatcg atatcttcac gcatggatgg aagggtctcg agcggcgatt 1775221 ccgctgtgag cttgaaatag atcgcgcaaa agagcgcatc ggtaaaaatg cttcgttcca 1775281 aatttaaggt cagctgggtt gagaaatgtt ttctgtacat gtcttttcgc ttcgcaaata 1775341 catgtttcgt acccgggcgc tcacgtttga tgcattcttc gatcctaatg tcttcaagca 1775401 gcataaagag ctgcttggca aaacttttaa acgtaagatg gcgatggata tcattcaaaa 1775461 agttcgcaaa ctcatgcagc gagctatatc ttgttccgac tgaacgcagg tagacgtcgc 1775521 ttttcagacc cgcttccatg tcctcagctg ccctgtcttt ccaaaagtgg ctcatataga 1775581 ttttcttttc aaatggattg taataggact gaacgccata ctccacttct accgcttcac 1775641 tcttggtgag tgttttggcc aaatcagtca gcatcataaa taaaaatgaa tcaatcgtgc 1775701 tgtcgttaaa tttgataaat ttcatcgcag ccccctcatt caaacagagt ttctgcaata 1775761 tttcggacag ccgctttttc ccgatcatca tcaagctttt ctacaattcc ccgctcaatg 1775821 gcacgacgcg gcggaatata agcagctaaa tcacatgtat cgattaaagc tctgatggat 1775881 gccgcttctt cagacacctg tccgttattg gcctgaacga tcaagtcaga ggaaagcgtg 1775941 ataaatctgt caatcaattt ctcgtctttc aaggctgact gagacatgag cacttgtttc 1776001 agcagctcgc ctttaatata aggcacatca atgatgacaa aacggttttt caacgcttca 1776061 ttcagaggaa cagttccgac atagccttca ttgatggctg caatgactcc gaaaccgctt 1776121 ttagcccgta tgacctcgcc tgtaaacgga tttgtcatca tttttctgta atctaataca 1776181 ccgtttagaa taggcagtgt ttccggcttc gccatattga tttcatctat ataaagaaaa 1776241 tggccttcct tcattgcctt tgtaacaggt cctgaaacaa actcgattgt tgcctggcca 1776301 gattgatttt caatcgtttt ataaccgacc aatgcctcag cgtccaagtc gactgaacag 1776361 ttgacgctgt gcatcggttt atgaaaatag ctggacaatg tttctgccag ctttgttttt 1776421 cctgaacctg taggcccttt cagcaggaca tttttcccca tggctaatgc aataatggcg 1776481 tcaaataaaa tggcttcatc ctccgcctca tagcctgatg ttcctataag cgattgaaac 1776541 tctggggaaa taggctgctc tttatatgat aaaagctttt gttgtatatc ttccggcaat 1776601 gttaagtgct gtagttgagt tgtcatagac agattccctt tcctattcat attccattaa 1776661 cgagtatact aaaaaagccc ctgtatgctc aatacaaaag ggcctggatg atattactgc 1776721 ttctcgttat ttcccaaaag ggctccgcag acaatacgcg caccggaatt gccgcttggg 1776781 tttgtcagat aatcgtccgc ttgttcatga ataataaatg cacttccgtc ctcgtcgaga 1776841 atatttagtt tacttccttt tttcagtgaa gtgtcaggcg cattcattat gacatctacc 1776901 tttccatcag caccgacttc aaggttcggc agatctccgg catgatgccc catcggatta 1776961 ttaaagccgt gttctttgtt cagtggatta aagggaccgc ccgctgattc aaaatccggc 1777021 ctgacacaag aacctttctc ataaatatga aaaccgagag aagcacctgg acgcaggctg 1777081 tttgcggaaa tatgaatatc gaggccttca tcatctgatt ctttgatctc tataaaaccg 1777141 actgctttcc cttcacgatt gaccagctgg acatgatgac caaacgctga cgtttcaacc 1777201 actttttttt ccggcacccg gttaggaggg tctggaggtt ttttttgtcc gcatccggca 1777261 actcccagtg ccgtcagcat catcaacagc aagagacggt gcatactgtc tcccccttgt 1777321 tttttctaac agtgtggtca atcattgtct ggtataaaca aaaaagccta taaaaggctt 1777381 tttgtcatac tcatttttaa aaataacttc ttgcgcccaa gtaccgctgt ttccaatacg 1777441 aattgctgag attggaaatg tcgacgcccg atgagcttgc atgaataaaa tcaccgccgc 1777501 ctagataaat ccccatgtga gacgggccgg atttatatgt ggtaaagaag acaaagtctc 1777561 ctactgacgg ctggctgact ttctgcatga cattccaata ccctgccgta ctcaatcttg 1777621 atatagatga tacattatta atgaggtaat aaatgaagcc gctgcaatca aaaccggcag 1777681 gcgtgtttcc gccccatcgg taaggcactc cgacatattt tttcgcttcc gttatcattc 1777741 tgtcaatctt cgaacctatt tgaatgtttg accctgagtt atcttttggc tttgttggct 1777801 ttgtcggatt tgaaggatta gattttgatg ctcccgaaat agtcagaacc tgcccgattt 1777861 gcaacacatc cgatgataaa ttgtttttat cacggatgct ttggacagtg actccgagcc 1777921 gatttgcaat tttccacagc gaatcgcctg cttttacctt gtacgtcgtt gtttttgagg 1777981 gattggagtt tgacggcttt ttggaaccgc tgtttccgtt cttaggtgaa ctgcttcctt 1778041 ttattttgag cacctgttta ggataaagtg tatctgatgt taagccattt aaggttttta 1778101 attcggctac agtcatattt aagctgtttg cgattttcca cagtgagtca ccaagcttga 1778161 ccgtatatgt actttttgaa gaacctgaag aattggaacc gctgtttttc tttgatccat 1778221 ttgatccgct tgaactgctt gtccctttga tcttaagctt ttgccccgga cgaatcaggt 1778281 cactgctcag gctgtttaag cttttaagct cagaaacact cattttatga tttttagcaa 1778341 tcatccatag ggaatcacca tatgcaactg tgtatgttga tgttttgctt gaattagatg 1778401 gggatgtcgt gctttttttg ctgctttcag gaaccttaag actttgtccg acataaagca 1778461 ccgttgattt caatttgttt tcggatttca gagctgatat tgtcgtatca tactggcggg 1778521 aaagtttcca aagagagtca ccgcttttta cttttatcgt ttttgcttcc gcgggtgctg 1778581 cggccatcga cgacccaaca actgcagaaa cagccaagcc ggctacaatc ttctttttca 1778641 ttcattcaac ctcctaaact gtttttttgc aaaaacagct agtattttgt ttccaaaaat 1778701 ggcacacaac tgttttatcg tcaatttttc agcaagttaa acccttttca aacatttggc 1778761 gcagcatttt cagcatcgtt cgacctttaa accttcaaat aaacatctaa cattttacat 1778821 aagcacgata tgtttttcga aagtctaagg aactatttaa gcgagggtaa aaatgatggt 1778881 tttctattga tgaacgaagc agtttctcct cctttcttgt ctatttttct aatcaattct 1778941 ctatcggcgt gtcaaatccc ttcctctgca ttcttatgaa atggcaaaaa gcctgttctt 1779001 tcgataagaa caggctttta cactatgcat ttgctgattg agttttttgt tttacagctt 1779061 caagaatgct gtcggctgct tttttagagc cgcctgccgc tttcagtgat tgtccaattt 1779121 cttttgcctt ttcagcatac gaacgattat tcattacttc ttgtatcgtc tctttcagta 1779181 ggctttcaga caattcttcc tttttaatta cttttcctgc gccgactttt tctacctgat 1779241 ctgcgacaac aaattggtcg cctcccatcg gaatgacaac gagcggggtt tcaaaataca 1779301 aaccttcact tgtgctgttc attccgccgt gggtcacaaa taagctggct cttttcaaga 1779361 tctcaagctg agggacatac gggcgtacaa tgaaattctc cggaatgtcg tttaactcac 1779421 ttgttttaat atgcttgccg atggaaagca caactttacc gtcaaagtcc ttacacactt 1779481 caaggcattg attaaaaaac tgcttttgat tattaaaaat ggttcccatt gaaataaaca 1779541 gcacgttttc attgtcaatc tgatcaaatg ggaaatcatt gtttccggct ctttctgtaa 1779601 tggaaggacc gacaaataca tatcgctcgc caaattgctc agccagtggc tgaaatcccc 1779661 ttgatgtaaa gacgattgtc aagtcaccat cagctaaaaa aacatcaaat ggcttcttga 1779721 tctctgcttg aaaatcagca tttaacgttt ctgcaagctg ctggtatgat tcataatgag 1779781 gcgaatcttc aagtgatcct ttcatgtacg ctcccatcat ttccttcgca aattcctcat 1779841 tcatcgcaaa ggttgtacac aatgaaaatc ttggcagctt cagcatgttg gcaatgactt 1779901 tacccgcgag aagatggtga tcatatatga cataatcata cgattcatgt ttgacttcct 1779961 cataaatatg agtcgcgata tccttacagg ctttcaaaaa agcgcagagc atttctgtga 1780021 aatctctttc ttcatcgccg gttgcgtttt tcccgaagta atctcctctg aaatcatgat 1780081 actcacgaaa ctctatatca agagctgtga ttttttcttt atattccttc actgcgtagt 1780141 acgtaatgtt ttctccccgg gatttcagct ccttcatcac accgatagag ggattaatat 1780201 gcccttcacc ggggaaaccg atcattaata cattagccat gcggcagcac ccttcctttg 1780261 agaatttatg taatatttta tacggtacta taaatgcata aacaggtaaa gtatttcact 1780321 taattaatat tcatcatata taacttttct accagtttat attccctgtc ttcaagacaa 1780381 aaagcattca gcttgaagcg aatgctttaa taaagatgcg aattcagtca ttttgtctca 1780441 tgataggatt cttaatcagg ccctttttat tatttttacg ttcttggtga aattaacgga 1780501 tataatacac cgtctttggc aaacgacatc ttccctgttt cctctgaaac cacgagcacc 1780561 agtgcatccg tatagcccga cataccaaga gccgcccggt gccgggttcc caaatggata 1780621 tccacttcct tcgtcgtcag cgggagcaca ttggctgctg acacgagttt gttttccctc 1780681 actaataaag cgccgtcatg aagagggttt ccgggaaaaa agatgctttc aattaatgaa 1780741 gagctgatct cggcgtgtag ggaggtgcct ttttgaataa aacgttcaac cgggtctgct 1780801 ctttcaatca caattaaagc tccatgctta tgttccgata aggctttaat cgccttggcc 1780861 agctcaataa atgccggcgt aaattcctca atgtatgatt gcaaataaaa ggaggatgca 1780921 atcccctgca tgtcctgaaa aacgtgcccc aaatcatcta attcacaaag gagacactgg 1780981 tctttttcgt gaagcgtttt caagattaga gatgcatcac ctaatatttg ctctaagtac 1781041 acctgtattt tccccttgaa cgcattttct gatatctgct catagcgcat agccttcatc 1781101 tcctgtttaa atttccaact tttcacgaat gcttatctta ttgatgcaca ttctattggt 1781161 aaaggaggga tgtaaagaat ggaaatcgaa agaatcattc agtatatttg caccttttta 1781221 ggcgtgattt cgctttcttt tatttatgcc caaatgttta gaaaaacgaa accgacaaaa 1781281 aaagaatagg cccggcgttc attgcttttt atacataaaa tgttataatt tctctcgtta 1781341 tgaaaaagaa acggagatca atgtatgaaa gaaactcaaa acgcccggga aaaaatcaaa 1781401 cagctcttgc acattttaat accgatattc attacccaag cggggctttc tctgatcact 1781461 tttctagata ctgtgatgtc agggaaagtc agccccgctg atttagctgg tgtcgccatt 1781521 ggctcaagcc tttggacccc tgtttacaca ggacttgcag gtatattaat ggcggtcacc 1781581 ccgattgtcg ctcagttatt aggtgcagag aaaaaacaga agattccctt tactgtttta 1781641 caagctgtat acgtggccgc gcttcttagc atcgccgttt tagtgattgg atatgctgca 1781701 gttgacctta ttcttggccg attgaacctt gatattcacg tgcatcagat tgctaaacac 1781761 tttttaggct ttttatcact gggaattttc cctttatttg tttacaccgt gttgagatca 1781821 ttcatcgact cattaggaaa aacgagagtc accatgatga ttacactcag ttctcttcca 1781881 atcaattttg tattgaatta tgtatttatc ttcgggaagt tcggaatgcc ggcacttgga 1781941 ggtgtaggcg cgggactggc atccgcgtta acttactggt gtatatgcat catcagtttt 1782001 ttcattattc ataaaaacgc accgttttct gaatacggga tttttcttac catgtataag 1782061 ttctcttgga aagcatgcaa aaatttgctc aaaatcgggc tgcctattgg gttcgccgtg 1782121 ttttttgaaa cgagcatttt cgcagctgtc acgcttctca tgagccattt tcatacagtg 1782181 accatcgcgt cccaccaggc agccatgaat tttgcgtctc ttttatatat gctgccgctt 1782241 agcgtgtcca tggctctaac aattgttgtc ggatttgaag cgggtgcagc ccgttttaag 1782301 gatgcacgct catatagctt aatcggcatc atgatggcga tcggcttttc tttgttcact 1782361 gccgcctgta tccttttatt cagagagcaa attgcgggca tgtacacttc tgaccccgat 1782421 gtgctccggc tgacacagca ctttttaatt tatgcgctat tttttcagct ttccgatgct 1782481 gttgccgcac cgatccaggg agcactcaga gggtacaaag atgtgaacta tacgcttgcg 1782541 gccgcttttg tctcttactg ggtcattggc cttccggtcg gttatatggt cggtacgttt 1782601 acaagcctcg gtgcattcgg ctattggatt ggattaatag cgggactcgc cgccggagca 1782661 gttgggctgt ttttcaggct ggcaaaactg caaaaacgtt attcgcaaaa acaacacatt 1782721 taaaagaggt gatcaatcat ggcaaaaaac aaaaaattat tcgagtatct ttcccagcat 1782781 gcggaaacca tcagttcaac atggtatgaa acaatcgagg agactgatcc caattccatt 1782841 tatgcctcaa cagaccctgt tgtcattcac aatttaaaga gccagaatct tgcctttaac 1782901 tataaaataa accgtatttt tatagatgat gaggacgtat acttgcctat actgaaagaa 1782961 tgggcctttg aagtcacaca ggatcaagag catttaaaaa ctcctatcca ctatattatt 1783021 cgggagtttg tcagagtgag agatttatat gtttcttatg tgaaagaatt tgtccatctc 1783081 aatcagaata ctgtgaaaag cgaagaagcc gaagacctgt atcacgccct tataaaagcg 1783141 tttgatcttg tgattcatat ttttatagaa gaaatgtaca aaaacacaag ccttcagctt 1783201 caggcccaaa aagatatgat tactgaattg agcgctccgg tcatcgtgct gtttcacagc 1783261 gtcggactgc tgcctttaat cggagatatt gatacagtcc gcgccaagct gattatggaa 1783321 aacacactgc atcaatgtgc gaaaaaaaag gtgacacaac tgtatattga tttgtcagga 1783381 gtagctgtga ttgatacgat ggttgcccat cagctgttca gtctgattga ggcgcttcgt 1783441 ttaatcggtg tttcttcaac tttgtctgga atccgtccgg aaatcgcgca aacagcggtt 1783501 cagctaggtt tgtctttcga aggtatttcc ttgagatcca ctctcgcttc agctattgca 1783561 tcggacttaa aattaaaaaa ggtataaggc ttaaggcctt ataccttttt gattaatcat 1783621 tccattgata cgtccaatat atttcttctt caaaccatgt tgccataaca ggttcattat 1783681 ttttcaattt ctcttcaagc tctctgagca tgccttctgt ttgtgtgcgg tgagctctta 1783741 acgcattcat tttaatatca gctacttctt tgatatcaag tacgacatca gcttcgccga 1783801 gaacctcttc tctgttgcgg gtaatggcca tgcagattgt acgcggacgg tcttctttct 1783861 ttttgcggta taatgcacgg ataaccgctt ccccgcatgc atcatggtca gggtgcacac 1783921 cgtgtccggg ataaaatgtg acaattaaac ttggttttac atcatctatg atctcttcca 1783981 tgatatcagc taaatactca tcgtcttcaa attcgagcgt tttgtcacgg agtccaagca 1784041 tccgaaggtc attgatatcc atttctttgc aagcgttgat gagctcttgt tttcttagca 1784101 gcggcaacgt ttcccgattc gcgaaaaatg gatcgcccat atttctgccc atttcaccta 1784161 aagtggcgca ggcatacgta acgggaatgt ctttttttct gtttaaggca atgaggcctg 1784221 ccactccata tgattcatca tcagggtgag gcaggattac tagtacatgt tctttcatta 1784281 ttattcaccc ttttctttaa actgtgaacg gtttttcgct gatttgcaga gaaatagcca 1784341 gtttaccgcc cggcaggtgt cccgccatta ataaacggtt ttcttcatct accgtgtatt 1784401 cagtcaagcc ttcagcataa atccagcctt cttctgtttt caagccaacg cggtaaggcc 1784461 cgttgccttt gatttttgcc tgatgataag tgacttttgc attgcgaata tacgcaacaa 1784521 ccgtcatgtt cttttcattt aagtgcgctg aataagaacc tgtggtggtt tctaaatgga 1784581 tatatacagg gcggtccgca tatcgttcta aagatgcttg cacatcttct tttatgatcg 1784641 ctttcatgat tgctcccctc tttcttcttt taaatactct gcacgttctg tatgtaattt 1784701 gaccagctga tatttcacag ccggttcgag ctgtgaattc acaatgcgct gaatcgcggc 1784761 aaaatatttt tccagcatcg gttttcggag tcttggatgt gttcgtttat ccaagagctc 1784821 aagatcaatc gcctctgcta ccgcttctgc gtcatcatgt gcgagagatc ggttattcca 1784881 aagtgaagca taggctttca ctatctcttt atcattgtcc atcgtcttgc tcctttatgt 1784941 cttacataca tgaaatgatt atacataata tatgcatcag ctgaaaagcc aaaggcctca 1785001 atggcttttt gacgcccgtt tccacttcac ttgtgaaaac gtaaacaaga gcagcgcagc 1785061 ccatatacag ctgaatgtaa aagccttcga gcttgaaaat ggctcatggt aaacaaacag 1785121 cccgatcagc agggtaatgg tcggcgcaat atattgtaag ataccgactt gatacagtgg 1785181 cagccgtttc gctccttccg caaacaataa gagcggcaaa gccgtaaaca caccggccaa 1785241 aaagagaagc agccacgtcc ctccgctttc tgcacccgct ggctgaacat gtccgctgaa 1785301 cagcaaatac cccaatgcaa tgggcataat catgaatgtt tccagcgtta aaccgatggc 1785361 gctcggcagg cttgttcttt ttttgcttaa cccgtacagc ccaaagctga atgcgagcag 1785421 aagcgcaaca taaggaatgg agccgtattg gaacgccgag atgatgacac cggctgccgc 1785481 aatcgaaacg gccactaatt gcaggcgatt cagtttttcc tttaaaaata aaatcccaag 1785541 gagcactgat acaagcggat taatgtaata gccaagacta gcctcaagca aaaagccatg 1785601 gttgacagcc catatgtata caaaccagtt gatcgaaatc aggatagaag caagaaataa 1785661 agagaggatc cctccgttct ttttcagaga gcgcaactcc tgccatccta ttttccattg 1785721 ccgcaagaaa aaaagtacga tacacataaa aacaaaagac catataatac gatgagccaa 1785781 aatatcaaga gccggcagct gttcgagaag cttccaatag agcggaaaca ggccccacat 1785841 gataaatgaa acggctgtgt aaataacgcc tttttttgtt tctgcatgtt gcattgatat 1785901 ccctgccttt ctttagagca tcttatatta tatcacgtga aagatctggt gggcatatac 1785961 tattttgtcc gtgaagaaag gatgtgaaga caatgtttga gtggaacaag tactttcctt 1786021 tccacaatca attttctaaa gaagcattaa aaaaagctga tccgaaagaa gttgaaacgt 1786081 atgtcaatcg tgtgatggaa agtgtgttcg gcagtgatta tgcggctcaa tttcctttcc 1786141 gcgatcctct cccccaaaaa gaacatcccg ccaaacctga tgcaaaacct gatgtcaaac 1786201 ctgatattga tatattcgaa acagcagacc atgtgtttgt aaaggtgcca atcagcgaag 1786261 aatggctgga acaagtgaga atcaaacaca catctcacga attatggttg gaaaacctcc 1786321 caagagcaga tcatccgaaa aaagtaaacc ttccttgttt agtcaaacgc aaaggaacaa 1786381 aagccgtcta taaggatggc cttctggaag tcatgtttca aaagcagcaa gactacaata 1786441 tgtccgaggt agaaatcatc cgataaaaaa cggcctgcaa tcgatgcagg ccgtttttta 1786501 ttaatagaag ccgggatatc ccccgtatgg cacgccggca ccaaaaccgt acggtccgcc 1786561 tccatatcca taagggccag gaggataggc atagggacga gaatagttaa acagcgcact 1786621 cccgagaaaa ccgcctaata aaccgccgac tagaggagcg ccaaacaaaa aaggactacg 1786681 cgccggatat ccggctggac ctgggattcc gcgtaaatac gaatgatgag ggtacatgat 1786741 tttttcctcc tttatgtctg cctatacgta aagtattcag caaggaagaa aaacgattgg 1786801 gctacggact gtctatgatt gttacatcac aagccctgcc aataacacac agccgagccc 1786861 tgtaaccgaa agaactgttg taagcagcgt ccaggtttga aatgtttctt tcatgctcaa 1786921 gccgaaaaat tcctttacca tccaaaatcc tgcatcattt acatgacacg caatgacact 1786981 gccggctcct gttgcaagca ccattaacgc agggtttaca ctgccagcct ccataagcgg 1787041 agctgccatt cccgctgtgg taagcgcagc cacggtagca gagcctagac acagacgcag 1787101 aaccgcggcg atggtccatg caacgaatag cggcgacatg tttgtttgac ggaaaaaatc 1787161 agcgacataa tcgccgactc cgccgtcaat cagcacctgt ttaaacgctc ctccccctcc 1787221 tatgatgagc agcatcatcg caatttgcga aattgattct gaaatagatc tgccgatttc 1787281 ctgcatagat attttacggg catatcccat cgtatagagt gcaagcaaca gcgaaatgag 1787341 cattgccgtt cccggagtgc cgataaattc tataatgtct tttccttttg aatgttcact 1787401 caataataaa gaaaaaattg ttgccattgc cataaagata accgggaata aagacgtgac 1787461 agcactgatc gcaaagcccg gtgtttcatc cagctgaaat tctttccttg gtcctaaccc 1787521 cgataggttt ccatgctttt gatacgcacc aggaaaccgt ttcatcgcaa atttattaaa 1787581 taaaggcccg gcaatcacag ttgtcggaac agcgatgatg attccaaaaa gcagcacctg 1787641 gccaatatgg gcaccatatg caactgagat agcagttgga gcaggatgcg ggggcaaaaa 1787701 tccgtgagta acatttaagg cggcggccat cgggattccc agatacagaa aaggcatttt 1787761 taattcttta gcaatcgcgt aaacaatcgg tatcaacaga acaagaccga cttcaaaaaa 1787821 tagggcaatc ccgatgataa aagaggcaac cacaaccgcc gcctgtattc gtttcctccc 1787881 gaatttgtca atcagcgtaa tggcgatccg gtagccgccc ccagcatctg agacaagcct 1787941 cccaagcatc gcgccaagtc caaacactaa agctaaatgc cccagctgcc cgccaattcc 1788001 agtctcaatt gaaagaacaa ttttattgat atccattcca agtccgatgg ctactaaaaa 1788061 tgaaacgaca atcagtgaga caaaggtatt taattttact ttaataatga gaaataacag 1788121 aatcagcact ccgacagcta caattaaaat cggcatggta cccctccaaa agtgttttat 1788181 atgattctcg cgacaatgtt ttggcgcttt tcatgcctag atgaacagaa agcgctttca 1788241 ttaataacta aaaacgtctt ggttatatga ttgttatctt ttgatcaact aatatgttca 1788301 tactaatctc ctaatcaatg actgtcaatc gtttttatga gcttgtctcg attacctacc 1788361 gcctaaccca atgatttatt agttatatgt tgattaactt ttggttatat gttatgtttt 1788421 ttaaagttga ctgccaatca ttatatctct ccattgtctg gaagcaaatg agacaatatg 1788481 agaacagacg gataacaact tcataagagg aggagtacac atgccattat tgcgttttga 1788541 tgtaattgag ggccgtgatg aaaaatcgct gcaattgtta ttagatactg ctcaccaagc 1788601 gatggttgaa gcatttggtg ttccggaaag agaccgttat caaattgtcc atcagcatcc 1788661 cgcaaacgag cttataatcc aggatgcggg attagggttt cagagaacca aggatatggt 1788721 catcattagc atgacaagca aagcaagaac cgaaagccaa aaggaaaaat tgtatgctct 1788781 gcttgctgaa aggctagaaa aaaaatgcga aatttcccct gacgacctca tggtatctat 1788841 tactgagaat ggtgacgcag actggagttt cggtctcggt gaggcgcaat ttttgaatgg 1788901 aaaactataa gatttcgtct ccccacaaaa aaaagaagag agagctccaa agaagctctc 1788961 tcttttttca taaatgcgga agtcatcagt atagaagcat ccagcaatac gaaaaacctg 1789021 gatctccttt tatatccggt ttaaatgcca attggaagct gactgggttt tggctgaaaa 1789081 tataaaattt tgctgatttg cataataaga tacatcataa tccccattta caataggttg 1789141 gatgttatag cttattgatc atttcctatt ttatatatcc ccttcatatg cacatgacat 1789201 ttttgccaat ccggaaatat cagtctgaca aatataaaaa gtcatgtaaa cgggtgtgaa 1789261 ccgtacttac atgactcacc atggaaacaa aggctctttt tcaggtgccg ctttccttat 1789321 ttctcttctt cacacactgt gtcaccaggc tcgcaaaatt gatcggccca tgcctgcatt 1789381 tcttgaaata cagcttgaag cgctgttcct ttttcagtca gcgtgtagat gactttgacc 1789441 ggcgtttcag ggagaacctg ccgttcgaca atctcgtttt gttcaagctc cttcaagcgc 1789501 tctgccaaca ttttttggct gatcatcggt attgtttccg ttatctcttt aaaccgtttc 1789561 ggcccatcca ttagcacatg gatgatcaga ccgttccatc gttttcccag caatgagaat 1789621 gcggattcca ttttagggca catcgtattt cccataagtc ttcatccctt catctattga 1789681 ttgacatgta ttcaatgatc cattacaata atctttcaag ttacatttag taagcttcta 1789741 acttttctat tatcatacca cgtttatccg aaggaggaaa cactatgacg aatactctgg 1789801 atgttttaaa agcacgtgca tctgtaaagg aatatgatac aaatgccccg atctctaagg 1789861 aggagctgac tgagctatta gaccttgcca ctaaagcgcc ttctgcttgg aaccttcagc 1789921 attggcattt tacagtattc cacagcgatg aatcaaaagc ggagcttctt cctgtagcgt 1789981 ataatcaaaa acaaatcgtt gagtcttctg ctgttgttgc cattttaggc gatttaaagg 1790041 caaatgaaaa cggtgaagaa gtttatgctg aattagcaag ccaaggctat attacggatg 1790101 aaatcaaaca aacattgctc ggccaaatca acggtgctta ccaaagcgag caattcgcac 1790161 gtgattccgc tttcttaaat gcttctttag ctgctatgca gcttatgatt gccgcaaaag 1790221 caaaaggtta tgacacttgc gcaatcggcg gatttaacaa agagcagttc caaaagcaat 1790281 ttgatatcag tgagcgctat gttccggtta tgcttatttc aatcggcaaa gcagtgaagc 1790341 ctgcgcatca aagcaaccgt ctgccgcttt caaaagtatc aacttggctg taaggatatg 1790401 aaaaacctta gtccgaaatc cggactaagg tttttttata caatcgcctc tttgtaccat 1790461 tcacgagcct gttcagcttc atgctgagtc agctgatggc ccccgtcctg ccagtaaacg 1790521 gaggctgatg ccccgctgtc acgcaaatag cggtaaagct cttctgattc ttccttcgtg 1790581 caaagaggat cgtatttccc ggcaccgata aaaacaggga gccccgccat atcaggcagc 1790641 tcgatacccc gaatcggaac cattggatga tgcagaatag ccccttttaa cacatcttta 1790701 taatgaaaaa gcaggcttgc cgcaatgttt gcgccgtttg aataaccgac tgcaatcact 1790761 cggccgcgat taaactgatg cgtttctgca gcctcgtcga taaaatcttt caattctctt 1790821 gtccgcacca caagatcctt ttcatcaaaa actccttcac tcagacgttt gaaaaatcgc 1790881 ggcattccat tttcaagcac cgatcctctg acaccaagca aatgggcatc agggtctata 1790941 aaccgcccca atgaaagcag atcgtgttca ttaccacccg tgccatgcaa cagcaaaagt 1791001 acgttgtcag atgttccttt ctcataaata tgcttcatta taaattcccc cttttaaagt 1791061 tcaggtaaaa tgtctgtaat ttgttgtcta tgtttctcca gccattcagg cagttttaag 1791121 gaagtcccta gctcagcaaa cgtttcatct gtcataaagc ccggttcatc tgtggcaatt 1791181 tcaaataaga taccgccttt ctccctaaaa taaactgatg taaagtattc cctgtcgaga 1791241 atttctgacg aaggcagatg gttttcagca ataatcggca gccatttcgc ctgttccttt 1791301 ttcttagtcc gaaacgctac atggtgtacc gtaccatatc ctccgactcc tcttttttca 1791361 ggatgtaaat ggacatcaat gacaccgccg accgccgctg aagatgccag tctgacaatc 1791421 tggtcttctt cggccacttt ggtgtatcca aagctttccg ttaacaattg tatggtcgcc 1791481 tgcgggtcgt aggaatatag cagcacacct ttcattcccg taattgcttc atttgttgtg 1791541 atcccgtcag gcgtccactc gcttttgccg cttttcgcat cctccatgat cgccagcgga 1791601 aggtcttctg tatcatcaaa aataagacct ttttcaccaa acaacgtttt ttcctctagg 1791661 ctcagcccgc ttttctcaag acgttccttc caaaaagaca gggagcctga gggaactgaa 1791721 aagtacaccc ggcccgcttg gccttttcct accgttccct gtccgcttcc ttggaacgga 1791781 aaaaaggtca ttattgtacc gggatctccg ttttgattcc caaagtaaaa atgatacgtt 1791841 ccgggatcat caaagtttac tgttttttta acgagcctga gcccaagcac ttctgtataa 1791901 aatcgcaagt tttcttgcgg atctctggcg aatgctgtga catggtgcaa tccttctgtt 1791961 ttcattttct cactcctatt tatctcgatt tcaagatatt tattatttta aacctttatt 1792021 gaaaaggatg caaaccatgt gttttgatta aataattgaa aaaatcattt ttttctaata 1792081 attatcttgt gatcttttct tacaactgct attatagtga gcattatcat gtttcaggag 1792141 gaaagtaaat ggttaaaaaa gcacttattg ttattctcat tcttttgcca ttcgttcagc 1792201 tcgcgctttt gccgcttgtg aatcgaatag aaccgattat gttcggcctg ccgtttttcc 1792261 acttttggct gctgctgtgg attattgtta cgccgttatg ctcgtttggc atttatcaga 1792321 tgcaaaaaaa agatggagga cttgaataat gcaagggaat ctgactgcac ttctcattac 1792381 tgctattatt gttttaaccg ttgtctgtat cggctttctc gccggaagag acaaatcctc 1792441 acgtacttct gtggaagaat ggtctgtcgg cggcagacgc ttcggcggtc ttctcgtctg 1792501 gtttttagta ggcgctgacc tttatacggc ctatactttc ttagggttga ccagtactgc 1792561 ttttacaggc ggaagtgttg catttttcgc cattccttat tctgtgttgg cctactttat 1792621 cgcctacttc ttcttgccaa aactttggaa agttgcgaaa attcataaat taacaacact 1792681 cgcggattat gcccgggaac gttttaacag taagcttttg gcaagcctcg ttgccatcgt 1792741 tggggtactc atgcttattc cgtacatatg ccttcagctg agcggcattc aagacacgct 1792801 tcaggttgcc ggcactggct atattaacgt aaaattcgtt gtgatcattt catttattct 1792861 tgttgctctt tacacattct tcagcgggat taaagggccc acatatacag ccatcattaa 1792921 ggacatttta gtatgggtca ttatgctgtt tatggtggtg tccctccctc tcattcattt 1792981 taacggctgg acgccaatga ttgacacgtt agtgaaggaa gcgccgcaaa tgctgacgat 1793041 accgtcagaa gggccaaaag gcattccttg gtttatcaca gcatctattg tttccgctct 1793101 ggcacttttt atgtgggcac atgccgctac aggtgttttc acggcgaaaa gcgctgatgc 1793161 agtaagaaaa aacagcatgt ttttgccgct ttataatatc gtgttaattt tggttatttt 1793221 tcttggcttt atcgcctttc ttgttctgcc ggaagataca aatccaaggc tggcgctgct 1793281 gcatttgatt caaacatctt acggcggcgt ggcacaaggc tttgcatatg ccactatcgc 1793341 tcttgcttca ttaatacctt gttccattat ggcaatcggc gcatcgaatt tattcgccaa 1793401 caacctatac cgggatttga ttcatccgaa tgtgtcgcaa agcaagctga ctcttgtcac 1793461 acgttcaatg gtgtttgttg tcatcggtct tgcgctgctg tttggaatgc tgttcccgac 1793521 tgccttagtg acacttcagc tattaggtgt atccggtatg gtgcaaatct tccctgcgat 1793581 tgctgtcagc ctgttctgga aaaaccaaac gaaagaagca acggttatcg gattattagc 1793641 cggcctagcg gtaacgttta ttgtgtatat cactcaatcc gcacatggca tttatgaagg 1793701 attctgggga ttggccgcca acatgatcgc tgtggtcatc ctgaatccgc tgttcgttaa 1793761 aaacgcggga tccaatcctg tcattgaagg tttatttggc aaaaaacaag acgctaatcc 1793821 aaatcaaaag ggcgcataaa aaaaccatac gcggcagccg cgtatggttt tttttacatt 1793881 tcttttttca gtgtttcaat tgccttttcc atttgcgtat cattatcaga cagcttcttt 1793941 tgaagttcta tcattaattt cgttgttgta tcgccagtca gtatgcctgt ttcattcagc 1794001 ttctcttttt tctggaactg tttgacgaca gatacaaaat cctggtcata catactgtta 1794061 acctttacct tgtaaccaag tgctttgagc attttctgag ccactttgac gtttgtgcct 1794121 gtatcacctg atttgtacgt tttatctgcg tccaaatacg gcagcttcgc gtaatcaggc 1794181 agctctgctt tcacttgagg cttgatgcct tttttgtgaa tccattcgcc atcagcagtc 1794241 agccatttgg caactgtcag tttgacggta gagccatcat catattcttt tgccgtttgt 1794301 actgtacctt tgccgaatgt cgtctcgccg attaacggta cgtttgacga ttcatgaagg 1794361 gcagcggcca taatttcggc tgcgcttgct gtaccgtcat ttactaaaac gacggtcggc 1794421 ttggtcactt tccgttcttt ttcggccttc atgacttctt ttgaaccgtt tttgtattca 1794481 acctgcatga tgtttttccc tttatcaatg aacaggttgc tcatcgtaat cgcctgttcc 1794541 attaagccgc ccgggttgcc tctcaagtct aaaatatagc ctttggcgcc ttttttctct 1794601 aaactgtcaa tcgcatctgt cagctcttta gctgttgttt cagagaaaga agtgatttga 1794661 atttctccga tgttgttgtc tttcatctct gaatagacag tctctacagg aatggtatcg 1794721 cgcttaatgg aaagatcgat attccccact cccgctctgt tcagttcaag cttcaccttt 1794781 gtgccctttt tgcctcggat taaagcgacg gcttcattta cattcatgcc ttttacgctt 1794841 tttccattta ccttaatgat ttggtccctc ggtttgatac cggctttttc agcaggtgaa 1794901 cctttaattg gggatacaat aaggatttct ccgtctttct cctctacttg ggctccgatt 1794961 ccttcaaaag atgctgaaat cgtctcgtcg aatgatttcg cttgctcttg atccatatat 1795021 gtagaatacg gatcatccag tgattgaatc attcctttaa ttgctccgtc tactaatttg 1795081 tcatcatctg ttttttggta ataatcactt ttgatttgct catacgcttt atttaatttg 1795141 tcgaacttgc tgtctcctgt gcttgctgat ttttggccca ggatactgga attgcccgta 1795201 ataaataaag taagcgccga agcgacaact gcagtgatca gcacaataaa aaacagtttt 1795261 aattgccgtt tcaattaaac accacctttt tcttcttaca ttattatcat ggacgaattc 1795321 ttattcgtca actcggagca gaaatgaaag agaaacgccc ttcttttgct tttcataaac 1795381 ctatgtcttt atacgacata tgataaggaa aaaggaggat tcgatattga gccgatattt 1795441 agaaatgctg tccttattcg gtgtcgcagg ggcgcaccca ggcgggctgg ctttttcaaa 1795501 agcggtcttg caaaaggctg caccctctcc ggatcagccg attcttgatg ccggatgcgg 1795561 aacagggcaa acggcggctt atttaggaca tttgctgtat cctgtaacag tcgttgataa 1795621 agatcctatt atgcttgaga aagcgaaaaa aagatttgcg aatgaagggc ttgccatccc 1795681 tgcatatcag gcggagctgg aacatctccc gttttcttct gagtcctttt cctgcgtcct 1795741 gtcagaatcg gtcctcagtt tttcacgcct gacatcctct cttcaagaaa tttcaagagt 1795801 tttaaaaccc agcgggatgc tgattggtat cgaagctgct ttaaaaaaac caatgccccc 1795861 tgcagaaaag aagcaaatga tggattttta cggatttact tgcttacatg aagaaagcga 1795921 atggcataaa ctcctaagat cctatggctt tcaaaaaaca gaagcgatgt cacttcttcc 1795981 ggaagacatg gaatttgaac caaccacaga aatggattta tcgcaaacga ttgatcccat 1796041 ctattacgat acgcttcaaa cacattatca gctcatgcag ttatatagtg agtacatggg 1796101 tcattgtatt tttatcgcgt acaagtaaaa cggcgtatcg ccccctgttt tcgtccaacc 1796161 tttttttcct atctatcata tgctgataga aagtcaggat aggaggggaa caatattgga 1796221 gagatattat catctttgca aaaaccatca aggtaaagtc gtcagaatta cagagagagg 1796281 cgggagagtt cacgtcggca gaattacccg tgtaacaaga gacagagttt ttatagctcc 1796341 ggtcggcgga gggccaagag gtttcggtta cggatattgg ggcggttatt ggggatatgg 1796401 agcggcttac gggatttccc tcggtttaat tgcaggagtg gctctggctg gtttattctt 1796461 ctggtaagca tagaacaaat gctagattca ccagacacaa tgaagcccgc ttatctagtg 1796521 taagcgggct tttcatttta aattttcttc actttttcaa agtactcttc aagcgttaaa 1796581 tcattatctt ggatgacctt tgcggctttt ttgcctacat agcgcagatg ccatggctca 1796641 tattcatatt tcgtgatatc ttctttattt ttcggatagc gaataataaa gccatattta 1796701 taagcattgt cctgcaccca tttcccgtct gccgtgcttc cgaacgcttc atttagctca 1796761 aagccattgc tccggctcga aatgtccatc gcaaggcctg tttgatgctc gctttcaccc 1796821 gggtaagcga ccgcttcctt tgccttcctt tcccctttta ggcttacttc attgtcaaaa 1796881 atgactttct gtctgtcata cgaacggtac cctgagacag ctgccagttc atagccttcc 1796941 tttttggcag catcgaacat tgtttttaat gcgtcggccg cttcttttct gatgtaacgt 1797001 ttttgaatct tttcttcaaa agaaaactct acatcaggta tgacaagatc gctaggttca 1797061 tagtttccgg gcagtgcata ttgtttattg acaagcgcga gtatattttc tggattttga 1797121 atggtttcca gaccatcgac ttttttaata tcattgaaat actggctttc caatgaaaac 1797181 tcactgtttt gagtgtttga ttttttgctg tcagctgttt tttgttctgt ttgctttgtt 1797241 tctgctgtgg ttttcgtatc cttttgagca tctccgttcg acatgctgca gccggctccg 1797301 actattgccg ttacactcag agcggcagcc agtgagaacc atttaccgga ctttttcata 1797361 ttacattacc ttccttttat caatcgtttc cgcatgcata aagaagaggc tgccggcacc 1797421 cagcacgcct cttgatatat tttattgtga tacggaatgt aaagccactt ctatcatatc 1797481 atgaaatgtc gtttgacgct cttccgctgt cgtttcttct cctgttaata cgtgatcact 1797541 cacggtgaga attgacaggg cttttcttcc gtgcttcgct gctaatgtat acaatgcagt 1797601 tgtttccatt tcaacgccaa gcacaccgta ttttgcaagt ttttcaattt gcgaatcgtc 1797661 attgtagaac tggtcagctg taaatacgct tcctacagtc accggcacac ctttatcctt 1797721 tgcggcatca taggcatttt ttaaaagctc gaaatctgcg caaggcgcaa aatcaacgct 1797781 tccgaaagca actctgttca tttgtgaatc agttgaggag gtcatcgcca aaatgacgtc 1797841 tcgcactttg acatctttac gaatagcgcc gcaggaaccg actcttatta gattttgcac 1797901 atcgtagctt tgaattaatt cattcacata aattgaaata gacggaactc ccattcccgt 1797961 gccttgtact gagatttttt tacctttata tgtacccgta aatccataca tgcctctgac 1798021 ttcattgtag cattctacat tttcaagata cgtttctgca ataaattttg ctctgagagg 1798081 atctcccggc aaaagcacag tatccgcaat ttgtcctttt tcagcaccta tatgtacact 1798141 catctcatat cctcctgtaa atctaaatta tcatccagcc cgtccatttt acaacgaatg 1798201 tcatgatgaa acaaacttca gcattgatta taaaggaata tatcgaaaaa agaaatgttc 1798261 gaggatctgt taggcacttc ctcagaaaaa cggataatcg gggtgttaat ttgaaaacct 1798321 aaccgcagga aggaggggtg ggacatgggt aaaaaacatc gtaaccggat caccggccaa 1798381 aaaaagaaca atcatatacc tgaaaaagat atcattgcag ctgaagaagc acacgggaaa 1798441 gaatattccg ctgccaaacg caagccttaa aactgcagaa aactgcgggt ttccgcagtt 1798501 ttcttttcat tatgtcgttt gtacaatcag acgattgatt ttcctccagc cggcgggaag 1798561 cagttgataa tatgttttcc cttttctgcc ttcatcaatc aggatcacgt cccctgtggc 1798621 catgaatctt gcatcataat cactcggaac agtgtcgaat acattaaaca aagagaatgc 1798681 tcttttcagc acgtcttgat gatcgctccc gttcagttca gttcgataga cggctctgta 1798741 gccctttttt tcgccaaacc ggggtgtctg aaatattgtc acgtcatagg aacaagactt 1798801 ctttttaaac acggataaca tcatcaagat cccctccctt ttatttcttt aacatattgg 1798861 cgtttttgct gtgttttcct ctctctattt ttgtcgaaac cgcttaatct tttcgtcaaa 1798921 accttttact aggaaaaaca gaagcaagcc gaggctaaag cctcctaaca cgtctgtcac 1798981 aaaatgaacc cccagataca ctctgcttat gccgactaaa acagcaatta caccggctat 1799041 gatatatacc atttttttat gcttagacaa aaacgggaga tgtttcacta aaaagtaagc 1799101 aataacagga tagacacaag cagcattcat ggaatggccg ctcggaaaac tgaaggatga 1799161 ttcatgaacc agcggtgcaa aatcaggcct cactctttcg atccattctt ttaagacttt 1799221 gtttaacagc cgatctgtgc cgaatactaa gagcatcaac aggccgtccc atgtttttct 1799281 gtagaaaaac atgcctgctc caatgatgac aattagaggg agcagaaaag aagaagcacc 1799341 aagatgcgtg atccccgtca tgacttcatt aagccatggc tgacggatca aaacagctgc 1799401 cttgcttatt gcttcatctg cagattgaac agcatttgta tgaatggccg cagctagaat 1799461 taaaaagaaa agaaacaaac taacgggctt gtacaatttt aaccacctca attttcacag 1799521 aagtcataga acatgaataa taaaaccgga gctgaccgct ccggttttaa gcctcactca 1799581 tcttcatcca gctcttcatc tatcatacat ttttctatca aataatcaaa ggtaatatca 1799641 gcgatttcaa acagctcatc ctcactcggt atgtagcccc gtcttgcaag ctctctgtaa 1799701 aaaaattcag cgatttcttc cgtatcaatc acaagatcta tttctttcat ctccgtaccg 1799761 cctccttttt tatgttttat gaaaaaacag gctgaattat acccggtgtt ctaaacaatt 1799821 ctttcagtca tatattgaat aaaaaacgag ccatgggagg ctgacgctat gattgctaaa 1799881 atgatggaag cactggacgg agaaagattt gatatcataa tggaaaaaac gctcaaagga 1799941 atgacgcgtg tgatgatttg gggctgtctg ccatattttt tatatgtctt gatccgtatg 1800001 ttcacaaatt aactgaaatg ctcttttaaa ctttccaaaa caaacatcat catgtcttta 1800061 tattcttcat cctgaaacat ttcgtacaga attttgtagt cattataaat atccagaagc 1800121 tcatcaacaa ttgacacagc aaggatgtga agggtatctt gatcttcatc accgccttca 1800181 aactgaagaa gagcagacga tgcgatatct tcgccgatct catggccagt ttctccgaca 1800241 taatggacaa acaacagctg atgcacaaac tggtccattt catattttct aagcaccagc 1800301 gtgagatcct cttcctccgt ttcaagccac tctccatcct ttaaacgggt cagctcataa 1800361 atgatatctt cccagccatc ttctaaatat ctccaaattt ctgttctatg gccgataatg 1800421 cgaaagagtt cttttccata atctttaaca taaacaacgt ccccaataag gaattcatac 1800481 tcaatatcaa gcttctccat gtcgacaatg acaccctcat aatctttata aagctgaata 1800541 gatgattcaa agtataaaac ttcgttatga ttgacttcat aaagatagtg tttatcaatt 1800601 tggtgtactt ttgtgatggt gccgactgtt ccatacataa tgacgactac gatatcccct 1800661 acttggaatt tcggtttatt ttgcttcatg gtgtctcccc ctcgccgcaa catttctcat 1800721 acgctatcgt atgccgggtg aagccaattc gcatgggcat gaaaaccaaa ggaaatatcc 1800781 aattatggta tgggtatgga cataaaaaaa tccgcagtga tctgcggatg aaacagctat 1800841 tatctgccgt gcacttcaga ctcgtattga tcccaagctt catcaaacgt cgccatcgtg 1800901 tgaaggtaat cagcattcag ctccaaatat gaactgattt catgataatc ggttgatgtt 1800961 tttggaaagc tgtgatcctc atacgcctga ttggcaaatt cactgatgct gtccttcggc 1801021 ttagggtgtc tgtatttcaa taaatagtga taaaaggatt tcatgggttt cccctcctga 1801081 tgtctgtctt ttgttgttct attatacagt tcaagtgtaa aattacaaca aaagaatact 1801141 gaaacatgac tcaggagaag tcaaaatagt tgcgtttcaa aattctttct gtctccatga 1801201 gctgctgata tgtcaggctt tcaggcagtt tttttgtttg aattaaaagc agctgatcct 1801261 caatctcttt aaccgtgttt tcctcttgat aggtcatacc gcaggaagaa cataccatgg 1801321 caggggtgtc tgtcagttct atagccctcg ttccatcagg gagctcccag tacaccgtgt 1801381 tcctgccggg caccgcttcg agctcgccgc accattcgca tgttttcatg aagaatcccc 1801441 tccgcattca gtctctttct gttttttctg ctgcgccaaa aatttctttt ctttgagctg 1801501 atctcttttc tcacgccgat cttttaatgt ttcatgctcc ggatttgcga tgtatgcctc 1801561 tctccttttg attctgtcta cattttcagg tgtaaacgaa acttctttgt cagcaaaaat 1801621 ggcactcagc ccgatcggct cctttttgtc agcggtttca gggaaaacgg actcaaaata 1801681 ggcgtctgcc tgattgggga tataattctc tggttccgga tatgacgtaa tcacaccttc 1801741 aaaatttctt aagatcactt tgtcaggact ttgtgacagg acatagtttg gctgcagggc 1801801 gattttacct cctccgcctg gtgcgtcaac gacaaaggta ggaaccgcat agcctgaggt 1801861 atgacctctc agcccttcaa tgatctccaa acctttggaa acaggagctc tgaaatgccc 1801921 tattccttct gacagatcac attggtaaat ataataagga cggactctga tttttaccaa 1801981 gtcatgcatg agctttttca taattggaac cgaatcatta atacctgcta atacgacagc 1802041 ctgatttccg accggcactc ccgcgttcac cagcttttca catgcctcaa cggattcttc 1802101 tgtcatttcg atgcttgtgt taaaatgggt gttcagccag accggatgat attttttcaa 1802161 tatctcgcac agatgatcgg taatgcgctg cggaaagacg acgggagctc ttgttccgat 1802221 tctgatgact tccagatgcg gaatgctgcg cagctctttt aaaatatatt ctaaaatttg 1802281 gtcgttgatg agcagcccat caccgcctga aattaaacaa tcgcggattt cgggtgtttc 1802341 ccggatataa gcaattgcag catcaagctg ttttttgggg acgcccattc cgatttgtcc 1802401 ggaaaagcgc cttcttgtgc agtagcggca gtacatggaa cattgattcg tgacaagaaa 1802461 cagcacacgg tcgggatagc ggtgtgtcag accgggtacc ggtgaatctt catcctcatg 1802521 aagcgggtct tccagatcgt attttgtttt gtgcatttct tcagaaagcg gcacagactg 1802581 catgcgtacc gggcatctcg gattgtcggg gtccattaaa gaagcatagt aaggtgtaat 1802641 atttaagggg atcgttttgg tagaaattct gacgccttcc tcttcatcct cggtcagatt 1802701 aatgactttc tttaaatcat ctaacgttct tacagtgtgt gtcagctgcc aaagccaatc 1802761 gttccatttc tcttccggaa cgtccttcca taactcgatc tccttccaat gccgtttcgg 1802821 tttataccat ttgtttttca aacgaactcc tcctcgcgca tattttgact tacagttgct 1802881 tgcaccaaat attcatgttt tcaaggcctt cggctataaa gcaattattg atcagccttc 1802941 cgccatactg ataacctgaa tggtacaaca cagcattcat cccaaaagac gaagcacggg 1803001 cgagagaaaa cacatgaacg atatcctctc cagccatttc tttttctaac gcctcgatta 1803061 aaaagcttgt taacgaatgg ccgcgatatt ccggcagcac agcgcaatcg gttatttctg 1803121 catgcccaag ctctggattg atttctgcgc ttgctgcgct gatcaggcgg tcatgatcaa 1803181 gcatgatata atacaccgta tttgcattca tcgtcttttc aatataagcg gggtcaaata 1803241 ccggggttgg gtacgtgcgg aatacttttt tatacagcat cgatagctgg tacatgtcgt 1803301 ttgtttctgc ttttctcatc gtaaaaacgg gtgtactgtc gttgcgaaga cggggcgctg 1803361 tgcgatatat ggcttcgatg atctcctgtt cctctgtata agaatctgtt tgtctccggc 1803421 tttctgaaag gtaacgtacc atgacacaag ccgaatggcc gagataatag ccctttagat 1803481 agccctccgg cgcaaataat tgtttggcaa ggatcggctc atcatgctgc ttcgcataga 1803541 caatgatttt ttctgcattc tcttcttttg ccgctgccac gatatccggc agggccttct 1803601 caatggctcc gtcataacga accactctga ttcgtttatt aaagccgtca tggtccaaaa 1803661 ctgctgtgac accgctactc tttattgact tgagcatccg catcctcccc atctgtatga 1803721 aggccgcacc aatccatgac aaaaagtgca ataattttag cagattctat catggcttca 1803781 acctcaatgt attcattggc ctgatgagcc gtttttgttt cccccggccc gaaaacgatc 1803841 actggtgtat ctcctgcatg gtacaaaagc cctccatccg ttccccacgg ggaagcctca 1803901 ataatcggct ctgtctgttt cattttttga taggctgatt gcagcacaga aattaaaggg 1803961 tgatcatcag gtaaatcatt cggcagccat tgagcgccaa accattcgac ttgtacggga 1804021 tggcgtttaa accattcgtc atggtattct aaatccttca gccagttttc caattcaagt 1804081 tttacagctt ctggtttctc atggggagca attccgcatc tcccttctat gacgacacgg 1804141 tctgcaactg aagatggcca ggcaccgcct gagatggtgc cgatattcac cggtaccggt 1804201 attgggatat tgtcatacag cggatctgaa attctcgcat tgcggacttt ctccagctct 1804261 tgtatcgctg tgataacgtg catgcttttt tcaatcgcgc ttaccccttc atagcgtgtg 1804321 cccccatgtg cggataatcc cttcacagtg atccgaaacc acatcgaacc ctgctgctta 1804381 ataaatagtt tcatattcgt cggttcagga atcagcgccc cgtcagcacg atagcctctc 1804441 atgatggcgg aaagtgtacc ggcgccgccg cactcttcat ctacaacact ctgaaacaat 1804501 acatctccct tcagtttgac atcgcaggcg tgcagggctt ctaaagcaaa aagaagggct 1804561 gtattgcctc ccttcatatc cgttgagccg cggccgtata ttttaccgtt ttcttcgaca 1804621 gcttgatacg gttcatactt ccaatccttt acgcttcctt caggcacaac atcgatatgg 1804681 ccgttcaaaa tcagggacct gcctccgccg gctcccgttt ttttagccac gatattcggg 1804741 ctctcatgaa aatcggatcg gttagattta aagtagggat gctgttttaa ttgctttatg 1804801 cttggctccc atacatcaat gtccatatga aattgccgca gcttttcaag cacaacagct 1804861 tgggcgttaa actctgaccc caatgtgctt ttttccccaa tcagcctttt gagaagacga 1804921 atggctttgg ccgaatgctg atcaagccac tcgattactt ttctttcaat gtcttgcatc 1804981 ctcattcccc ctcttaagaa aaaggcatat ctattttgat ttcagcttct gtcagcctcg 1805041 tcacctcatc gattgtcgag ccattcatca gctcttttaa aatgaagtga tggctatcga 1805101 cctcaagaac cgctttttcg gtaataatca aatctacaca gcctgcagca gttaatggca 1805161 gcgtacatct ttctgttaat ttaggccttc ccttttgatc tgtatgactc atgacgacaa 1805221 ccactttttt cgctttttgg gcaagctcca tcgccccgcc cataccaggc accttttttc 1805281 ccggaacaag ccaatttgcc aaatctcctg attggctcac ctgcagggcg cctaaaatcg 1805341 taatgtcaat tttgcctttt ctgatcatcg caaaagacat ggttgtatca aaataagaag 1805401 ccccttttac agcgcggaca ggatatcccg cggcgttgca taaatgcgca tcctcttctc 1805461 ccttttcggg actttctcca atgccaagga caccgttttc cgcttgaaac atgacctgca 1805521 tgtcaggctt caaaaagttc ggtaccaagg aagggatacc gataccgaga ttcacaatca 1805581 tgccctgctt aatttcagta gcagcgcgtt ttgcaatctg ttctctttct gctactccca 1805641 agcccatttc cacttcactc cctcgcttcg tacaaccccc tcaacaaaaa cccccggtgt 1805701 gacaatcatt tcttcagaaa tctcccccat cggaacgata cgctcagctt cggcaaaggt 1805761 tctcctggcg gccattgcca taagcgggtt catattgcgc gcggttttgt catacgttag 1805821 attgccgaat tcatctgcaa tgtaagcatt gatgaaagca aaatcagcag tcagcgcctc 1805881 ttcaatcaag tatcgttttc ccgccactgt tacgatgtcc tttttttcgc aaaccatttg 1805941 attatcaatg cccacgtcgg ttaaaatacc gccaagcccc gctccgccgg cgcgaatccg 1806001 ttccgcaagc gttccctgag gtgaaaattg aacctctaac gtcccctctg tcatctgttt 1806061 tccggctact ggattggaac cgatatgcga ggcgatcagg gttttgaccc gttgattaac 1806121 aataagcggg ccgattccga tatccgggaa accggcgtca ttgcaaatca cagtcaaatc 1806181 cgttacaccg ctgtccaata tcgcttcaat caatgaagga ggcgacccga ctcccccaaa 1806241 accgccaaac atcagaaccg atccatcccg aacatctgca attgctgtgt caatgctgat 1806301 tgctttttga aatggcgcca tttaatgtca atcctttttt aagttttttt cgaccgctgc 1806361 aactgtttct gaaaaaatag agataagctc ttccatttca ccgtctgaaa tagtaaaagg 1806421 aggagcaata atgacagcat ctccttctcc actgtctatt ccagctttgg aaggataaac 1806481 aatcagcccg cgttttttcg cctcgctgac aataagctgg gttatcgcct gctctggcgg 1806541 aaacactttc ttcgtttttt ggtctgccac aaattcaatg cctaatagca gtccttttcc 1806601 gcgcacctca cctataatgc cgctttgaga tgccgcctca tcaagcttct tcttcagcac 1806661 agcgcccttt ttttctgatt gtttgatcaa gccgtgcttt aacacatatc gcaaaacttc 1806721 aagagcagct ttggctgaat agggatgtgc actatatgtg tgaccgctca taatcacacc 1806781 tgacccttgt tttatggttt caataataga atcagatacg acggcagcag caataggtgc 1806841 ataccccgca ccgagtccct tccccagtac agcaatatca ggtacggtat cccaatgctc 1806901 tgtcgcgagc atccttcctg ttctcccaag ccccgtcatc acttcatctg caataaaaag 1806961 cacatcgtgt gtgcggcata cctcacttaa tctctcataa tatcccggag gcggagtaat 1807021 cgctgctcct gcagcaccaa taataggctc agccacaaag ccggcgatga attggcttcc 1807081 gattctttta atcatggtgt ccagttcatc agctgcagtc tgaacaaagt cttcttccgt 1807141 ctcgtgattc agccgataaa tatgtggagc tgagatagct ggataccgct caatgagatg 1807201 ggtgaaccgg tatctccttt cataaaaacc agacaatgaa agcgctccca aagttattcc 1807261 gtggtaactg ctccatcgag acaaaaagat ggatttttgt gtttgctttt tttcctgcca 1807321 atactgaatg gcgattttca tagctgtttc tatcgcttct gatccgctgt tgacaaaaaa 1807381 agaccaattc acatctccgg gcagctcctg tgccaagaga gcggctaatt gctcggcggg 1807441 ctcactcgta aactgtgagc ggtaagcaaa agacacctga tcaagctgtt ctttcagctt 1807501 ctcagtcaca tcacgaactc cgtggccgat attacatgtc accgcacctg acgagccgtc 1807561 gagatatttt tttccggtct gatcataaac atatgaaccc ttcgcataac tgacaaccgg 1807621 ataggccgag ctaagctctg gcttaatcaa ataactgctc atgctcccac ctcaaaaccc 1807681 cttttaccat attgtatgag tgtccaaatg gcggcatgac gttccccgca aaaacttttt 1807741 cacataaaaa gagccttcct aataaggaag gctcttttga aatttcagca tctagcaaat 1807801 aaaagcggct ccaacaataa ttaataaaat gaacaagaca acaattaaca caaatgtatt 1807861 tgtcccgcag ccaaatccgt aaccgtaccc agagtatcca tacatgctgt tttcatcctt 1807921 tcttatcacg atatacgaca ttttatgcgg gccaagtccc aaatggtttg tgcaaacgcc 1807981 tatttcatgt aaggaaataa tgaaatacag tatgcacccg ctcatatttt ttaaacgtca 1808041 gcttttcgta aaactgagtt gcaccgtcag tgcttgcagc cactaagtag gctgcttcca 1808101 ttcctagtga tttggcgatg gacagcattt ctttcactaa gatactgccg tagcccttcc 1808161 tttgaaactg atctaaaatt gccacttctt cgattttagc cgttttctct tgatgatcga 1808221 taaacagctc gccgcaccca atgggaactt tctgtgcctg gtcgctgtaa caaacaacaa 1808281 gaatgattat atctgcttca tagaaaggat attttctttt taatttttgt tcagcgattg 1808341 cttctccaat ataaatggaa tcgtaaattt tcataataga agatccgtcg ctaagacttt 1808401 ttgccgtccc ccatgcggtt aaaggatgtc ccatctgccc cttccagtca ctaagcttca 1808461 tgtcatatag tagctcatcc tcgacgacaa aaccgctttt tacaagtgac tgcttcaaac 1808521 cgagcggaaa aacatgctgc ggcgacgctt ttaaatggag ataattcgca tcaagcagct 1808581 ttggtacgga gggtaaaaag ttaagtaacc gctccaatgg aaacgtatca tggagctgaa 1808641 caaagttatg agaaaaaatt tgcggaagct gcggatctct gtatacgctg taatgatcaa 1808701 acgatgccga ttcagacgtt aacaatatat attgatgttc cgtttttgaa taatgtcctg 1808761 tcatgaacgt ctccttttta tgacctatac ctttactctg ttgcaatatt caatttcttt 1808821 ataatctcat cgtacaccgg ataaaacggc tttccaattg gaaattgctg aatatttcgg 1808881 aaagaagcgg agattggctt ctgatgtaaa aaaaacttcc ttgttacttg ttcactaatc 1808941 gggtgaaaga cgccgtttag aaacaaaaac ggctcgcgtt cgatgaaaaa cagacgtcgg 1809001 ccaggcggat ttttgatcaa ttcagatcgt ttccacgtaa tcggcggccc ttccggaagc 1809061 gtctccatct cttcttttcc aattgtcact atgtcttttc tttgaaattg ataaaattga 1809121 aacgcatact ggtccacaat tcgccttttt tttccggctt cgatataaaa tattgcagga 1809181 tggtcagctt cctttactaa aatataattc ggaatgttta aaattttgcc aatcctatat 1809241 tggaataaat atgggtctgg aacagcgaca gtccgattta gatacaaaaa accccacttt 1809301 tctccaacag gatgccttac accctgatca aaaaaataca cattttgatc tgaacctttt 1809361 acaaaagagc cgtcaatcaa atcggcgggc agaaaccgat atgcattttg aaatgaatct 1809421 ggggttttat aggttgtgtc taatacttca tttatcggca gaaatggggt aaagttgttg 1809481 agtctcgccc aaaaaattgc gtcgccatga ttccaatgct tcatatcatc atcccagtag 1809541 cctccaaatt tatggtgaat gagattaagt aacgaacggc gatgcataac tgagcaatga 1809601 tcaacttgaa aagcggcctg atcaagcact gcattggcat ttctgtagaa atgtgagatt 1809661 tcctctcccc tttcgtttac atgtacaact ttttgttttg aatagaccgc ctgcgcttca 1809721 ggcttatgtg aaaactcttg caccatacgg ctcagccgct caggatgata aacagtgtcg 1809781 tcagtaagat aggaaatgta atcgccgtct gcaaatggga gcgcactgtt aattaatgtg 1809841 gcataacggg ctgtttttaa tcgatctgca ggatgcacga aactgttatg atattgaatg 1809901 cgccggtcat ggagatactt gtgaatcacc gcagttgttt ctgcattcga atgatcatcc 1809961 atgataaaaa gctcccaaag atcatgcgtt tgctgtatca cgctttcgat cgctttttgc 1810021 aaataatcgg gtttgttgta acttgttaaa ataatagaca ctttctctcc catctatacc 1810081 gcctcccgcc gtcaaacata aaaacggctc cgcagcaagc agagcctctg tcatcattta 1810141 aaaagcaccc cagcttacaa cacttgagag tgaaacatga gatctcgtgt tatttaacgg 1810201 gttttggaaa ataaccaaat cagtcagaac ttcttttacg atgacatttt gaagtgtatc 1810261 tccgttgatc aaattgactt ttgaaaccgg tacgcccagc tcttttgcaa aaacaagctg 1810321 gcgtctgagg tcagatggat ttccttcaga agacgattga cgtatcagca gaatcagcaa 1810381 aagcaaaata aaatgcagat catcttggtt ttcttctcga tccacttgtt tctctaaatc 1810441 caaatcatcc ctctccctta tccttatctc tgtttcacaa tatgtgcgac ttcgatttat 1810501 ggtataggct atgtccactc cattaaaaaa tcagcatttt ccttaaatag atgaaaaata 1810561 gatcaggtac ggcgttcgac tcataccaaa taacagccgg aagaatatga ataacgtgag 1810621 ttcactatcg aataggaggt gtgtgtaatg agctctgaaa atgcacagtt aaaaaaggat 1810681 ttaattaaag ccgttttaag ccctttattt ccaactgcaa cagaaggagg agaaaatatg 1810741 gatagtaatc ttaaagcctt gcttgatgct gccatcgatc aaaaagtaga tgaaagtgaa 1810801 acggttacgg cagaatctat tttagaccct tctcttccgg caagatggat ttttgccaga 1810861 attacgccag gcactacaat cagcattgtg actgattcag gtgacatgat cggaccggtt 1810921 gttttcgttg ctttcgatca ggttcacggg atcgtatttg taacacagga aagctccgtc 1810981 actccggcag gccaagctac aacattaatt gatgtagaca aagtagaaag cgttacgttc 1811041 ttttcataac atccgatgaa agtcttgtat atccagtcgg gatacggagg aatatacagt 1811101 tattttgatc gctgggctga agaatgtttt cagaacactc atacagagta tatgattgca 1811161 gataaacctg aagcagaatc tttgatgaag atcgaagcgt ttcagccgga tttcacactt 1811221 atgatggttg gagaccgcgt tcctcacgac tggctgacct ggttaaaggg taaggatatc 1811281 cccgtgtatg tttggctgac cgaagaccca ttttatatgg atatcagcct tcaggtaatt 1811341 aagcttgctg acgccatatt aacgatagaa caaaatgcag ctctctacta tcaagagctc 1811401 ggctaccaga acgtctatta tgttccgata ccagttaacc atcggctgtt taaaaaaatg 1811461 ggcaccgaac attcctatca ttcaaatctg ttaatcatcg gctatcctta ccctaatcgg 1811521 gttcagctta tgaaagaagc ggtccatctg ccattcacgg ttcgggtaat cggcaaggaa 1811581 tggggaaaat atctgcctaa aaaagtgctc aaacagccgc atattgatgt cgtcagcaca 1811641 tgggttccac ccgaacaggc cgttcattat tataatgggg cagacatcgt aattaatgcg 1811701 catcgtccct atcattttgc tttcaaccaa aatactatgc gcatcaaaaa tgccagtttt 1811761 aataaccgaa cgtttgatat cgctgcatgc gaagcatttc aattaacaga tttacccgcg 1811821 gcgcatcctt tttcatccat tatttcttat cacggcatga acgactttaa ggaaaaagcc 1811881 gctttctata tcaaccaccc tgaagaacgg caaaaagctg cagcagccaa ttataaagag 1811941 accgtacccg catttacgtt tgatgagctt cctgcaaaac taaaagcgat tcatctggcg 1812001 ctttcttgaa aaatcgttca ttgctatgaa cgattttttt attcatagaa aaaagcagct 1812061 gcacaagctg ctttctattc tagccgtcag aacggtcttt cagcttcctc ggatttacct 1812121 gtttatgaag atcaggcatt tcgccgagat gctgtgcaat ttgttcccac gatacaattt 1812181 tgaaattttg attgacggct tgtccgttat caatattttc gccgtcctgc gccacaaaaa 1812241 tcccgtacgg atattttggg ccaagtccga aaccgagaac atcaatacca tccgtgtcac 1812301 tagtaccgtc tatcttctcg ccatctgtaa tctcaaagtt ggctacatag cgatttttcc 1812361 cctgccgttc atacattgca tagctgttat ttccttgact tgaagccatg agatatcctt 1812421 tgccatttgg tgcataatag attgtcagtc cttcaatatc agctgtcaaa tgatctcctg 1812481 tcgcacggtc aacaacctgc ccctttgacc ctccgccggg ctcagcgtta aatttccaga 1812541 tggcctcatc ttcctctgct atgtataggt ttccgtactc atcatccgca acaaggcctt 1812601 cggtctgaga attcaactta aattcacgca cctttttccc tgttacataa ccctttccac 1812661 catcaacaat ttcatactgc tcaaattccc cttgtttgcc tgtcactaat gcgtaaaatg 1812721 ctcctgtttt ctggctgtga tacaagctga atccataaac ctcagaaata ttggtggaaa 1812781 taggatggtt cggatctgta atgcttttca attttccttt atccccgtct attgcatata 1812841 cttcaattgt attttttcct tcggaccggt tggatgcggc agcaatatca attttttcgc 1812901 cgttcaatgg aaaatcatag cgcagatcga cattattgag cttgccaaac tcataagaat 1812961 gaagctgttt tccgtctaaa tcatacacaa cgagccctga cttcttattt gttgtaatca 1813021 acttgctttt ttccgggtgt ttttcatgaa cccaaatggc cgggtcatct gctgcatcat 1813081 cgccagatgc gaccggatct gtctccgtgt gtgcagtcac tttgaaatga tgttcctcat 1813141 tcacataatg agccgacacc gaggttgctg tcaggctaag caataaaccc gcggcagtgc 1813201 ttagcagcat tgtttttgga accttcattt ggtaccctcc tcttttatca ctaacactac 1813261 tattgtaaaa tatatacagg tgattaccgt gaggaaaatg aacctttttt tatagggttt 1813321 ctgactcata aacaacttat tccccaaaga ggtggtgaga tgactttgcc agatttactt 1813381 ttgcggagcg aaataaaaat atgttgaata tttagtacat tatttattta gttttgtttt 1813441 tccctagtta cgtccgtttt tccattttct attaaaaaag aacactttgt gacatgatca 1813501 ttcccctaaa ttttgtttta ttggttgctt tcattaattc gattacaaag ttgaacatat 1813561 gatgcatggt agagaaacga gagttggagg ataagccatg cctaaacagc aaacagcaga 1813621 actaaaacca tttttccata acaaaacagt tttagtcact ggcggaacgg gttcaatcgg 1813681 gagtcaaatt gtcaaacgcc ttttgatgct tacacctaaa caggtgattg tattcagcaa 1813741 agacgacagt aaacagtatg tcatgagcca aaagtatgcg gaggataagc ggctattatt 1813801 tgtacttgga gatgtacgcg atcacagaag ggtgaatcag gtgatgaaag gcgtcgatat 1813861 cgtctttcac gcggctgcgc tgaaacaggt tccgacatgt gaggaccatc catttgaagc 1813921 gatccagacc aatctcatcg gcggacaaaa tgtggtggaa gctgcccttt cacaccgagt 1813981 gcagcatgtc attaatatca gtacagataa agctgtatct cctgtgaaca caatgggtgc 1814041 caccaagctg ttatctgaaa agctgtttca tcaagcaaac cgccacgtcc aaaacaaagg 1814101 aaccttgttt tgttcggtcc gctttggaaa tgttctcggt tccagaggtt cggtcatccc 1814161 catattattt gaacagatga tggagggtga acctctgacc atcacagaca aaaacatgac 1814221 cagatttttc atgtcaatag acgatgcagc tacattgaca ttacaatcgg ctgctattac 1814281 aaaaggcgga gaaaccttta ttttcaaaat ggaatcactg aaacttgaag aactgattca 1814341 tgggtttgaa gaatatgcat cgcagcacgg gctcccgcgg ccggctgcag tagaagtggg 1814401 caagcgtcca ggtgaaaagc ttcacgaaga attaacatct ccacatgaaa ttgaatcact 1814461 gtatgaatgg ggcaaccttt atgcgatcct tccagagccg gaaaaacatc ctgactttcg 1814521 caaagtcaat ctgcctgggt atcaatcaga tcaagccccg ctcattacga aagaaagaat 1814581 tgctcagatt attgaagaat tgcatcaaga gaaaaaggca taaaaacaag cctgtctatc 1814641 cattaggcag gcctgttttt aacagtttat ttattaaaga gatgcagata gctttcgtat 1814701 ccttcttctt ttagcttatg cttcggaaca aaccgcagcg ctgctgaatt tatgcagtaa 1814761 cgaagtccgt ttggccccgg tccgtcatta aatacgtggc caagatgaga atcagcagtt 1814821 cggcttctta cttctgtgcg aatcatgccg tggctcgtgt ccagtttttc ttccacttct 1814881 tcttcaatcg gctttgtaaa gcttggccag ccgcattggg aatcaaattt atctttggat 1814941 gtaaacaatg gcttgcctga cacaatgtct acatacaacc cttcttcctt atgatcccaa 1815001 tattcatttt gaaatggcgg ctccgtgccg ttattttgcg ttacttcata ttgcatgcga 1815061 tttaatgact ttattttttc ttctttattg tacgccattt atttagcccc ccaatgctcg 1815121 ctgataaatc ccgctcgtcc ggaacctgtc cggtagcgct gataatgtgc tggattcttt 1815181 ttataaaaat gctgatggta gccttccgct tcatagaaag gttcagcttt taaaatgtcc 1815241 gttacaatcg gatctttaaa gatgccgctt tccgccagac gttgcttgga agcttccgca 1815301 agctcctttt gtttatcatt atgataaaaa atggctgcgc gataggaact gccgcgatca 1815361 gcaaattgcc ctccggcatc tgtcggatcg atttgctgcc aaaataattc aagcagtttt 1815421 tcataaggga atacatcagg atgaaacgtg atttgaacgg cttcacgatg tcccgtcgtt 1815481 tcactgcaca cctcttcgta cgtagggttt tcagtatggc cgcctgtata cccggacacc 1815541 actttttcaa ttcccggctg ttcgtcaaaa ggtttaacca tacaccaaaa acagcctcct 1815601 gcaaatgtgg cgatttcttt tttttcagac atactggtgc ctcctttgtt aatacgtggt 1815661 attattatat tatagcatgt aaaaatagaa tgaaaatgat tctgcttttc aataaaatct 1815721 ataggtttta agcaatatgc ttatgtaatg gaggttcaca aatttgaaag taagaacaca 1815781 gatgatgtac gatatggaaa ctttactccg taaagtcttt aaacaaatac gcaatgaaat 1815841 caatgaaatt ttagataaag agctgtcgcg gaatgaattc accattcttc gaatccttag 1815901 tgaacaaggg cctaaaaaag tcactgaatt tgcgcctatt ttagaggtat cggcaagcca 1815961 cattacggct gtgaccgatg cgctggtaga aaaggaatgg attacgagaa tcagatcgaa 1816021 ggaagacaga cgcatcatcc gcattcatat cactgaagcg ggcgaaaaag tccttcagca 1816081 ctttaacgag aaaaaaacgg aatatttctt taaacgcttt gactgctaca ctgatgctga 1816141 acttgccacg ttaatcgagc tcttcagcaa acttgataaa aaacggtgaa aaaaagcaca 1816201 taccgatata taggtatgtg cttttcgcag tgcttcactt atttttcagt aaacagcttc 1816261 attgctttcc agcggccata tctataatac aaaaatgccg cgcagctgct aaataaaaaa 1816321 ctcattccga ttccaagccc gattcctttt tgtccaagcc aagctgaaaa tagagctgtg 1816381 aaaggatacc tcaacaccca aaacgagatc aaatttaata ccagaacctg cagcatcgct 1816441 cccgcggccc tgacgattcc gttcagcaca aaattaaccc caataaaagg gtagaaaaac 1816501 gcgatccact tcaaatattg ttcaccaaat gcgaccgcat caggctcact gataaataac 1816561 cttatgaggt atttaccaaa tacccaaatc ataaccgcaa tcaccagcat gcaggaaata 1816621 acagctatca cacctagcct tgcaattgtt cccactcttt tttcgtttcc gattccaata 1816681 ttttgccctg ccatactatt gacggccgta ccggcagcca ttgctggaag cgtgatgatg 1816741 ctatcaagcc gctgcaccgc gccaaagcct gataccacgt gatccccgta tgagttaaca 1816801 acactcataa tcgccatcat accgcctgta atcaccatca tctgcagacc tgccggaatc 1816861 ccgagtttca aaatcagcgc ggactcttcc cacttgggca ttctcggaat cgagaatggc 1816921 acaagcttgt gtttgatgac ataaaacaac ccatacaaaa acgcaatgcc ctgtgacaaa 1816981 atcgttgaat aagccgctcc cgctattccc atgcggaaca cagaaataaa gagcggcgca 1817041 agcactgtat tcagtacaac agcaaacgca ataaaccgga gaggtgtctt gctgtcgccc 1817101 agcgcacgaa gcacagtact gataaagtta taaccaaaca aaaataaaat gccgataaat 1817161 tgaatctgta aatacgtctc agcaagcggt atcattgact ccggcgtttt tagaagacgc 1817221 agcaaaagct ctgagagaaa aaaaccggcc gcgccgaatc cgatgcttag gcctgttaat 1817281 aaaacaacaa aagcgttaat atacgacgcc attcctttta tatcatcttt tcctttttgc 1817341 tgagataaaa tggttaacgt cgcattgtta aggcccaaaa taaaagacag cacggtcaaa 1817401 acaatcgtgc ttgataccgc ggctgcccca agggcctttg cccccagtaa attgccgatc 1817461 cacaagctgt ctataaattg aaaggaaacc tgcaatgcgt ttccgagcat aataggcatt 1817521 gaaaacagta caagctgttt cagcacgttc ccctgtgtaa aatcgtatgc tttcatcttt 1817581 tctccttgtg ttctcaaatt ttcttcggac cacacgaaaa aagagacgtt gtttcatgtc 1817641 tcttttttca tgacttatcg gttttttttc ggtctcgcat accgaatgta aacaccatca 1817701 cacttaggaa caaggcacaa taggaaacat tcaaatacat ttgatccata tcttcagcag 1817761 ccagatgatg ataagcaagc cagccgaagt acagggaaaa tgtaaaggat aataaactga 1817821 aatactggta aatccgtttc attttcagtc acctctattg tttaggatgg taataggaaa 1817881 actcaatttc atctttttct aaatttatct tatccgcttt gacatacatt ccattcgtta 1817941 aaggcatttc tgacaaacgc acttcaatgc ttttatctcc ggggtgaaca tggacaaatg 1818001 acggcaattc ataaaagctg tccatataat ttaacacaaa gctaattggt atactcaatt 1818061 tccctaacga aaatttcgtg acattcagct ctacatcacc gttttttttc acggtcggct 1818121 caaaagcgat aaacgcatca atagacgtgg aaaatgcctt gattttccct gcgacatgaa 1818181 catcatcatc aatctctact ttataatcaa gcttgtttga tgctttgtcg tttaaatatg 1818241 agttaacaaa cgcagctaat gattcttttg tgcttgtcac ttgaaatcca tactcgctct 1818301 cagatgcatc tttcacctga gcctgttccc ccggaagcaa aacaagtgcc acaaacccgg 1818361 cggcgaggat aaaattgatt gcaagcaata taaaaaacag tcgcttccac ttattcatgc 1818421 tgtcacccta ctctttcggt aatccttctt ttttaatggc ttgatagacg cgctttgcga 1818481 taagagaata acccgtacca ttaggatgaa aatcatcttc ctcagaaatt cggctgctgt 1818541 cacttttttg attaaacaaa tcttcgatat ggacgatttt tgcatgttta tcttttttca 1818601 gctctttttc agcaatatgg ttccaatccg tgacgacacc atttatttca tttagttctg 1818661 ataatgtaaa cgtaaacgga ttgtacatgc tgacataaat cagctcagcg tgatcattca 1818721 gctcgcgaat ttcagaaatg attttttcaa agcgcttttc gtacggtttt tccgcttcct 1818781 gaaacggttc aacggttaat tgcagaaagt tttggcgaag gattttcatc aaatcattac 1818841 cgccaattgt aaaaaagaca taatctgcgt cctttatgcc tttttgaacc tttttatctt 1818901 ttagtttttc taataaatca tccgaacggt tcccttttac agcataattt ttcacgtcga 1818961 ccgttttgac ttgtttatct gaccggatag aatccgccac cttgccgaca tatccctttc 1819021 cgtcgggatc tccgactcct tctgtcagcg aatctccgac agccgctatg acaatgtgtt 1819081 cttttgtttt cgtttcatgg gctttttgtt ttccctcaga tgatgtacgt atgctcgtac 1819141 acgcagtaag aagcaaaatc aaactggcca tgattgaaaa aatgcgcagc ttcaatcttg 1819201 ttgctccttc ccattctact agtggaaagt gtatcatgtt ttagaagatt tgcaaatgcc 1819261 tagtctctta gcttacttga gtgtactggc tgacttcaca tcggaaatga tatcatcgta 1819321 cggtgtattc tccactccat tgtaatcttt cagcacctta ccgtccggac ctaccaaata 1819381 aaaagaagat tgatgaatca cttggtcctc tccctccggc ttctttacga tcgctttaaa 1819441 gctcttaagt gcgaactcct caatctcact ctggctgtat cccgtgagaa aatcccagtt 1819501 atcaaaagat aatggataat ttgcggcaaa tttcttcagc tgtttcggct tatcgttttc 1819561 tggatcaaca ctaaatgata tgatgcggac atctatattt tcggctttca gttttttttg 1819621 cagatcggtc atatgagcgg tcattggcgg acatatagtt tcacaattgg taaaaataaa 1819681 atccgccagc catacttctc cttttaaact ctctaaagaa acgttcttgc cgtcttggtt 1819741 ttgaaatgta aaaggctcca cctcgtaatt gagcggatct ttaatctgct gtcctccgca 1819801 tgcacacaaa aacagaaaaa tcagcccagc cgttaacccc ttgataacct tcatgacatc 1819861 catcctttcc agccagcata aaaacgcttt ctaaaaccgt ccttactgtc ccatgtttgt 1819921 attcgatact gagcaaaaaa aatcctgcat gcctccccat taacgattac aaaggagggc 1819981 atgcaggtaa aaaacggcat gttacgcgtt gtgctttaac acctcttgat gaaatacagc 1820041 ctgataatct gcccacttca tccgccgctt catataatgt cggaaagaat acacttttgc 1820101 cctgctgttt gatgaaaaca cttcttttaa gtagaattgc aaatggtgat gtaacataaa 1820161 gaaatagtgc tcatcttcct ttaatacagg tatttctgtc actttcacct gaatcccgtc 1820221 accgcgtttg aactctaggc ttttgagtaa caagctatca atcctctttt ttgtttttct 1820281 tctattatat atgatgccag ccgggctgtc tgtcattttg cgcggttgtg taaaaaaatt 1820341 agattagcaa atggaacaag tcctcatcct tgttcacctc tacataatga aacggttttt 1820401 tgttcatccg ttcaatcagc ggcccataat cggctttgtt ctgcagctcg atgccgacaa 1820461 gagcaggtcc attgctttta ttatttttct tcgtatattc aaaccttgta atgtcatcat 1820521 tcggcccgag gacttcgtca agaaattcgc ggagcgcccc cgctctttgt ggaaaattga 1820581 cgataaaata atgctgaagg ccttcaaaaa tcaaggaacg ctccttcatt tcctgcattc 1820641 ttccgatatc gttattgccc ccgcttacca cacacaccac gtttttccct ttaatttgat 1820701 ccttgtacaa atcaagcgct gcgacagaaa gagctccagc cggttcagca acaaccgcac 1820761 attcgttata taattcaaga atggatgtac atacttttcc ttcaggcaca aggagaatgt 1820821 catcaacgac agtttccagc gtccggaagg tttcctcgcc aattttttta acagccgccc 1820881 catctacaaa cttatcaatt ttatcaagtg tgacgacatg cccagctttg tttgattcaa 1820941 agtaggatgc cgctcccgcc ggctcaacag caattacctt tgtatcagga gacacgtttt 1821001 tcaaatatgt acctacccca gagagaaggc cgccgcctcc gacacttgca aaaagaaaat 1821061 gcggttctgt atcaatgtcg tttaaaatct cgactgcgag cgttccctgt ccggccatca 1821121 catccggatc atcgaacgga tggataaacg tccgagattc cgcctcacag cattcagcag 1821181 cgcttttata cgcgtcgtca aacgtatcgc ctgtcaaaat aatatcgata aatccttttc 1821241 cgaatagttc aacttgagat actttttgtc tcggtgtagt agacggcata aaaattttcc 1821301 cgtgaatgcc aagatgttta cacgaaaatg ccacaccttg agcgtggttt ccggcacttg 1821361 cacacacaac tccgttctct gtctgctcgc tggaaagctg tttcatttta tgataagccc 1821421 ctctgagctt aaaagatctg acaacttgca agtcttcgcg ttttaaatag atattgcatt 1821481 catatctctc agaaagtctg tcattcctct gcaaaggtgt gtgaatgaca acgtccttta 1821541 cgttttggtg agccttcaaa atgtctttca cttggatgag agagttttct ttaagcaacg 1821601 gtttcatgta cagattcctt tcttgtttta aatccctatt taatatgcca ttataacatg 1821661 aatattcaaa aaataagaca attattttta tttaataatt aaaaaaatac agactatgtc 1821721 caccacatct tgtggtaact tctgttcaac cattatcctg cagagccaag aaaaaagatg 1821781 atcgtaaaat aaagggtgtt ttcaaccaaa aggcatgata taatgaaacc aattagaacc 1821841 aaaaggagcc aattgatgaa tagtgcacca aaactcaata catttcaaca tctaatcgga 1821901 gaacatcaaa cttttctgga agcgaagcga atcgccaagc agttctcgtt atcggagctt 1821961 cctgtcttaa taacaggaaa aatcggaaca ggcaaaaatc acttcgcaca tgccatacac 1822021 ttggaatctt cgagaagcaa tgaaccgttt ataagcgtca attgcagcac ccattcggaa 1822081 gaaaccctta ttcatgagct ttttggccct aacggaaaca caggtgtttt tcaaaaagcg 1822141 gtacgaggaa ccctttttct tgatgatgta tggcgcatgc ctgcttctgt acaagctcag 1822201 ctgttaaaag cgcttgattc agacacggag aaaccgcgaa tgatctgtgc ttctgcagac 1822261 cgatccgtgg aacatacatt caggcaagac ttattctaca gactgaacat tttaacgctc 1822321 acactgcccg aattatcgga acgaaaaagc gatattccgc ttttgacaca gcattttctc 1822381 tcaaattctg gtcagcaatt gttaatcgat ccctccgttt ttcccgtgct tgagaagcat 1822441 gcatttgaag gcaatgtcag ggaattaaaa aacgctgcag attatatggc ggcagtatca 1822501 agcgggggaa cgattcagcc atatgacctg ccgccgtata ttagaggcac gatagacgga 1822561 aaaacgtcga agaaaaaagc gaaactgctt actttaatgg aaaaagctga gtttttgttt 1822621 attttggaaa caataaaagt attgaacgaa aaaggagaac ctgccagcag acggatcatt 1822681 tctgaacaca gcaaaaatac ccaaacctcg ttaactcctc agcaggtcag aagccgtctc 1822741 gactatttgg agaaaaaaga ttatgtcacc aaaagccgcg gacgcgcagg cacaaaaatt 1822801 acctttgagg gcttgagctt tatagagacg ttaaaaaatc aaatgatcta gcgatcgaaa 1822861 ggagaatgta cttgtttaca atcaaagaag agatcgccaa tgcgattaca cacggcatcg 1822921 gtgtcctctt atccatccca gcattagtgt ttctaatcat atttgcggct aattacgggt 1822981 ctgcatggga cattgtcagc tttacaatat tcggtgtctc tatgctgctg ttatatttga 1823041 gctccaccct gcttcacagc atcacacata aaaaaacgaa ggacattttg gagattattg 1823101 atcatagcgc aatttacgta ctcatcgccg gaacctacac gccttttttg cttgggccgc 1823161 tgaaaggcac actcggcttt accctgttgg ttatcgtatg gtcacttgcc ctaggcggaa 1823221 tcgtttttaa aattttcttt gtgaaacggt ttatcctatt gtcaaccttc gtgtatttag 1823281 tcatggggtg gctgatgatt attgcagtta aacctttata tgcttcactg agcggagcgg 1823341 gattcagcct cctttttctc ggcggcattt tatactctgt cggaaccatc ttttacattt 1823401 ggaaaaagat ccccttccat cacgccattt ggcacagctt tgtattgggc gggagcgctg 1823461 ccatgttttt ctgcgtgctc ttctattgtg taaaggtgcc tttcctttcg taacagtaac 1823521 agaaaagcgc agtcttcacg actgcgcttt tttatgcacg taattgtttt tcattggcag 1823581 gtatataagc ttttgaaaag gacaattcaa tgtctgccgg ttttaagcgt ttaaaaaacg 1823641 agccattttg catgttatct gttcctttcg tttccaccat caccaacgga agatgatagc 1823701 gggccgcaag ttctacagga tcaatagaac catctagtga aagaatcagg ctttgtccct 1823761 tttccagctg ttttgtcaca tcttcatata ccttttctga atccccgtct gaaatcacat 1823821 ccatccgatc cagccattgc ccgataaaag gcaagcggaa cacttttggg ttagcgataa 1823881 agccggccgg ttcctcaata tatccagcaa ttaaggccag ttcagccaaa cgcaaacggg 1823941 gatgcacata caaaacagga ccgtgtggta ttggctctgg ctgatggatc gtcacaactg 1824001 aaccggagat gccgatacag ccttctaaaa acgcctttgg ctgttcgtac acaagagcca 1824061 tctgtttttt gtatgacaga cggggatcga gcattgtttg attaaataat tgtttcatat 1824121 tttttaacag catatacaca atataaacca ctagaaggct gtagcgaacc aattaaaatc 1824181 ctcccgcttt agaagaattc tttttttcat acattagaaa ttcgtaatca tacgggtttt 1824241 tttcgtcttt ggtcccctgc tcagaagaaa ccagcttcca attggattca tcaaattcag 1824301 gaaagtgacg gtcaccctca aactcgtgat gaattttcgt catatacagt ctgtccgcat 1824361 aagggaacag gtccgtatag agctgagccc ctccgatcac aaagcattct tcagggcctg 1824421 aacaaatgtc cagtacatcc tttaatgaac tgacaaccgt gcatccctga aattctgaat 1824481 ccggcgctga ggtaacgaca atatttttcc gatttggaag cggacgtccg atcgattcaa 1824541 atgttttccg gcccataatg attgaatggc ccgatgttat tttcttaaag tatgcaagat 1824601 cattgggcaa atgccacggc aaatcattgt ctttgccgat aagcctgttg gcatccatcg 1824661 caaaaatgaa tgaaatcata cgctgaccgc cccttttata tgaggatgcg gatcataatc 1824721 ctcgatgata aagtcctcaa atgcaaagtt aaaaatagaa tcaacctttc tggcgaaacg 1824781 aagctgcgga agcggtctaa catctctttc cagctgcaaa ttgacttgtt caatatgatt 1824841 ttggtaaata tgaacatcac caaacgtatg gatgaactcg cccggttcaa gcccagtcac 1824901 atgagcaatg atcatggtta ggagggcata agatgcaata ttaaacggca cacctaagaa 1824961 aacatcggca gagcgctgat acagctgaca ggacagcttg ccgtcagaca catagaattg 1825021 gaacaggcaa tggcacggcg gcaacgccat tttatcaatt tcaccaacat tccaggcgct 1825081 gacgattaag cgtctggagt tcggatttgt tttaatatct tcaataagac gggaaatttg 1825141 atcaatggtt tctccatcag ctccccgcca agaacgccat tgggagccat atacaggtcc 1825201 aagttcaccg ttttcatcag cccactcatt ccagattcgc actccgtttt cctgcagata 1825261 gcgtacattc gtatctcctt ttaagaacca cagcagttca tgcgcaattg atttaaagtg 1825321 gagtttttta gtggtgagca tcggaaagcc ttcccgtaaa ttaaatctca tttgatatcc 1825381 gaaagtgctg attgttccgg tcccagtccg gtctcccttt ttctcaccat gctctaaaac 1825441 atgtctgcag aaatccttat actgtttcat ttttttcatc ctttaaaagt agtcttctag 1825501 tagtgtaaca caataaaaaa tcatttctga acccagaaat gattttttta tagtcagctg 1825561 acgacaggct tttcatcctg ttctttttct tcatcttgca gatcctgatg cgtatgtgca 1825621 attctgctcg ccgctgctgc agcaagagct gccacaatat catccaaaaa ggtgtgaata 1825681 ccgtctggac tttcatcaag ttccttaata attccaatct tctctttatc caaataaccg 1825741 aaattggtca aaccgatcga cccgtacaca ttaacgattg aaagcgggat aatttcatct 1825801 atgccgtaaa gcggttcatc cgtttcaaca aggtgctgca gcggttcggg gagaagtttc 1825861 tgttctgcaa gctgatcgag tgcaaggcct gtcaaaacag catgaataat ttcacgtttg 1825921 ttcaggactt tttctacatt ctccatgcaa acactgagcg gcagatttgg attgtatttt 1825981 tcctgaagtt tttgaacaat ccgtgcaata tcttctatca taacgccccg tttgttcagc 1826041 atatcctttg ttatatcgac catttcattc attgtgtact ttttcatgtc taatggcatc 1826101 tcctttaggc actcatccag ttgggaggcg tgttgcggtc ccagtaaatg ctcccaagct 1826161 catgatgtga ttgaaatcca tcttctgctg tatgataatg aaaattaaac cagtagccgt 1826221 catgaggcgg gtggtctctt cgcacatgga atctgagaag atcttctcca gttgtccgat 1826281 tgtaaacgtt gaaaattttt tccgttttgc ccgctgaagg catgcttgag atcacaacat 1826341 cttggtacgc ctcatcatct tgcaatgtcg ctaaataatc actaatcaca ttttcgattt 1826401 ttggcaggat ctctttccga tagtcatcct caatgacagg agcgattctg ctgccgaatt 1826461 ttaaaaagga ctgatcctca gcgctgtcaa ggagctgttc cttgtacgat tgaaaaagca 1826521 gttcaggatc tcgcctgtca tccgactcat catcgtacag gtcatgctca tcataaaaag 1826581 cggtgtaatc attctgctca agactgctcg gctgtccgga aggcttgtcc gccataaggg 1826641 cagccggagg agatacgagc ccgaacgtta caatggtaaa taaaaccaca agggtctttc 1826701 tcatccacaa tttcatgact gcttattcct ctctatttta ttgtcatgtt tctcttattt 1826761 tagcacatcc aaaacatgca agtcatgtac tatatgaaac tgatatgcaa attaggagat 1826821 tcgttgctat gcactttgtg taaaaacgct tacaatattt catgaaagga ggctttccgc 1826881 atgattgacg ctctgtttgc cacagtttca ctcttaacat tattatactt tgtcgtcatg 1826941 gaggtcaccg attaacagaa agcccgtgat atgaatcacg ggcttgtttg aatgacgcca 1827001 taatggaaca gtgctgtttt tcttttcatg acgttaaaac caaactgttc aaaccgcggg 1827061 cttttccagt ggtcttttag cacaacgctt tttctggcga ctcgtaccgc ttcattgata 1827121 catccttcgt gcaaaacgga atcctctgcc aaatcacgta aaggcgcgat gccgtcagag 1827181 gtttctacag gttcatgaaa cattggatcg aaataaacca catcaacaga gttgtcaggg 1827241 agctgcttga tgtgttcaaa gcaatcacca ttcttcacct ggattcttct catcgcagct 1827301 tgaagctctt ctatacccgt ttcccatgaa tgcagccccg tcctcactaa aacagacaca 1827361 agatggtttt tttcaatccc aacaacagaa cccgtttcgc ctactgccat acttgcgata 1827421 atggcatctg accccaaccc gagtgtgcaa tctaaaaacg tatccccttc agataagccg 1827481 gcagcccgaa gcataggttc tttctccccc tgtaagaagc gtttggctct gaacatcgct 1827541 gtattcggat gaaaaaagaa tttggcacct tgtttcgtat acagctcaaa ccgctctttg 1827601 ccgaccacaa gcaaatcacg ttcagctgat ttcagcaggt gctcaaccgt ttgtttattc 1827661 cggccgcagt atggcatatt tagctcttta gaaagctgct ttgcagtttt tatggtgtgt 1827721 tcagacggtc tatagcttgt tgttatcatc ttctgtactc ccaaaaagaa aatgcccgga 1827781 gaacgggcat ttagcagtgc gcatcgaagg cagcagtcag atttttcatg atttcttcca 1827841 tatcgtgtcc ttcaatttca tgacgcggaa taaaatgtac gacttctttg cctttcaaaa 1827901 gagccattga tggtgaagaa ggctcctggc cagtaaaata ctcacgcatt ttcgcagtag 1827961 cttctttatc ttggcccgca aatacagtca ccgtattgtc aggtgttttg tcattctgga 1828021 ggactgcctg tgtagccgca ggacgcgcaa ggcctgccgc gcagccgcat acagagttaa 1828081 cgactacaag agttgtgccc tctgcctttt ccataaagtt ttctacttct tccgctgttg 1828141 ttaactcttc aaaacctgct ccagtcagct cgcggcgcat cggtacgaca agctggcgca 1828201 tgtattcttc ataagccatt gacataaaaa aagccccctc tagtatcctt catctgaagt 1828261 aaaggatact atagagaggg ccggatttca aatgttcacg ccttaaaata aaagaaagtg 1828321 tccccagcta tctagatttt cataataccg ccggtgttgg cacttgtcac aagtttagaa 1828381 taacgtgcca ggtagccggt tttcactttc ggttcaaaac ctttccagtt cgcttttcgt 1828441 ttttcccact cttcttctgg cacttgtaca tccaagatgc gtttttcaat atcaacgata 1828501 atatggtctc cgttttcaac aaaggcaagc ggcccgccct cagcggcctc aggtgatacg 1828561 tggccgattg agaggccacg ggaggctccg gaaaaacgtc cgtccgtaat caatgccact 1828621 tttggcccga gtcccattcc aacgatttgg gatgttggcg ccagcatttc cggcatgcca 1828681 ggtccgcctt ttggcccttc gtatctgatg atgacaacgt cgccttcttt tacttttcgg 1828741 ttgataatgc cgtcaagcgc ctcgtcctga gaatcgaata cgacagccgg cccttcgtgt 1828801 cttgtaatcc cattctgtac gccgcctgtt ttaatgatag cgccgtccgg agctagatta 1828861 ccgaataaaa cagcaaggcc tcccttttca gtgaatggtt gatccagcgg gtgaatgacg 1828921 tcataatcct ttacttcatg tccggcaatg gtttctccaa gagtttttcc tgtaacagtc 1828981 agcgcatcta aatgaagcgc tccttctttc ttcgaaagct cattcagagc cgctgaaacg 1829041 ccgcccgctt cgtgaagatc ttcaataaac acatccgatg caggcgccag cttagccaag 1829101 tgcggcacgc gctcagcgac ttcgttaatg cgttctaaag agtattcaac gccggcttcg 1829161 tttgcaaggg caagggtatg aagaacggta tttgtagaac ctccgagcgc catatcgagt 1829221 gcaaacgcgt tatcaatcgc ttttactgta acaatatcac gcggtttgat atctttgcga 1829281 atcgtttcca ttaattgcgc agccgatttt ctcacaaact ctttgcgttc cggagatgtt 1829341 gccagaatgg ttccattacc cggcaaagca agaccaagtg cttctgacag acagttcatt 1829401 gagttcgccg taaacatgcc tgagcaagac ccgcacgttg ggcatccgaa ctgctctagt 1829461 tcttgaagct cgttttcgtt gattttccct gcttggtagg cgcctacccc ttcgaatact 1829521 gaggaaaggg agatttttcg cccgtcactt gttcttcctg ccgccatcgg tccgccgctg 1829581 acaaaaatcg tcggaatgtt gatgcgcatt gccgccataa gcattcccgg tgtgattttg 1829641 tcgcagttcg gaatacagac cattccgtca aaccagtgtg cggatacaac cgtttccaca 1829701 gagtctgcga taatttcacg gcttggcagc gaatatctca taccgatatg ccccattgcg 1829761 atgccatcat ctaccccaat ggtattaaat tcaaacggaa cgccccctgc ttctctgatt 1829821 gcttctttta cgattttccc aaactcctgc aagtgaacat gaccgggaac gatatcaatg 1829881 tatgaattac acaccgcaat aaacggcttg ccgaaatcct cttcttttac ccctgctgca 1829941 cgaagcaaac tgcggtgcgg agctctatcg attccttgtg tgatcatatt actgcgtaat 1830001 tctgccatgg tgatcctcct aaattctttc aattgtttga ttggatttta ttttgacaat 1830061 tttcagttta tttatgggct gtttttgcaa ataagataaa tacaggccgc cctcaccttg 1830121 ttttgttctt tcgtgttttt atatttatat agctttcttt cgatttgaac cctccaacta 1830181 ttaatattgt tacttactat aaatagtttt cggatatttt tcaacaatat tcgaaataat 1830241 ttttataaaa agtgaattca cataaaaaag gtgcatgatc tgcacctttt ttatctttat 1830301 tcgccttttt ttctgctttc cgtcatttgt ttccaaacag aaccttttgc ttcttctcca 1830361 tgctcaatac gttcaagcgc cattttgact tgaaggctga cctcaaattc ggggtcatct 1830421 tcggcagcgc gcaaagcttc aattgcactt tcatcgccga cttcgtacag gaacatggcg 1830481 gcacgccagc gaacaagctt gctggagtcg cttaatgact tgatcatagc aggaatggct 1830541 tgaggatcgc cgatatcaga caggcagtct ccggccgttc ttctgactga tacagctttg 1830601 tcctcaagtg ctttatacaa tagaggaaga acatcaggtg tttcaatcat tcctaagtac 1830661 acaacagcct gtcttctgat ggacaccttt ggatcatcca atgccttctg taaaaccggg 1830721 atatcctctt ctttcggatc catctgttcc aagtgtgcat aacgcttttt ccagtcctca 1830781 tcatccagca tatcaagcgt tactttatac gctttgcgct gtacagcttg ttttgcttcg 1830841 ccctttcctt gagcggctgc ttcagtcagt cgtttcagcc gttcatcact gtatgccgct 1830901 tgaagctctt ctgtcacatc atggccgatt tcatcaaagt caccgaatct gacaccttgt 1830961 tctttccaag cccgctcaaa cacaacattg gaagcttcag atctaagttt taagatcgcc 1831021 tgctgaaagc gttcaggtaa gccgaagcgt tcttcccgct ctccatcggt taatttaact 1831081 tgcataggaa tgccgctgaa catctgcaca aaaactttta cctctccaaa agattcttga 1831141 tcagaacgat tttcttctgc gctttcagca ctttccatcc caaatgcagt gcggacttgc 1831201 ggtaaaatgt ctttccagtc gtatcttgca ttccgttcaa cagcaagaaa atctgcgacg 1831261 tgatataccc ctttaactcc atctatttta aggatttccg ctataacaag cggtgcgcct 1831321 tctgcttgct caggtttata gttattgctt ttgcccgccg gaagctcttc cgttaagatg 1831381 actttcattg tattcgggct tggtgtaggt tcaattgatt ttatcttcat gatcgtcctc 1831441 ctatagcata tctgtgactt attctatcat agtcgctcca agccttctat tacgacgttt 1831501 cggcatcaat cccgggtatg tctttttcta attggcggac aaattgaagc ataaaattgt 1831561 gtctttcttc tgccagttcc cgtgcagtgt ctgtattcat catatctttc agccgcagca 1831621 gcttatgaaa aaaatgagcg taggcgcttt gctcatctcc ataaaggcca tgcccttttg 1831681 cgcccgcaaa catgaaagct ctcgcaatgc cgacagcacc aatcgcatca agtctgtcag 1831741 catcctgtac agcttttcct tcaattgaga gcggctcctt cgccaatttc cccctgtccc 1831801 gaaaggacat ccttgttata atatgaatca ccctgtcagc attctctttt cctactccga 1831861 aaaaaacgag ctgatcatat acttcgctca cagaaagcct gaccgtgtca ggcagcttca 1831921 catcaattaa atcatgaacc aaagccgccg tttcaacaat gaacaaatcc gctttttcct 1831981 tttctccaat atacgctgca agatctgcta ctcttgatac atgatgccag tcatgtccag 1832041 agctttcgtc agtcaggata gattgaaccc atgtcctgat ttgctctgcc tgcttcaatt 1832101 ccttcacaaa aacaccctct ttttattgct ctaatagctt cacgatatcg tcttccaact 1832161 ctttcggatt tgtatttggt gaataacggc caacgatttc tccatttcta tccactataa 1832221 atttcgtgaa attccacttg atcgccttag ttcccagcat ccctttcgca tgttctgtca 1832281 aatacacaaa cagcgggtgg gcgtttttcc cgtttacatc cacttttgaa aacataggaa 1832341 atgtaacacc gtaatttgtt tcacaaaatt cctgtatgtc agcctcttca ccaggctctt 1832401 ggttcatgaa ttgattgcag gggaacccta agatctccag cccctcctgc tgatatgtat 1832461 catataattc ctgcagctgc ttcaattggg aagtaaaacc gcacttactt gctgtattca 1832521 cgatcatcag tacctttccc gcgaaaggct gaagtgtcat gtctttccct gtgattgtac 1832581 gtaccttcat atgataaata gacatgtaag tccctcctat gtccttggtg ctgattattt 1832641 tacctttttt aaatcgcaat tcaaaatgta aacatcaatt aagaactcat aagaaaccta 1832701 acgatatgag cgtcagttca ttatcaattc atatggctcg ttttttatct tatcattcta 1832761 taaaacatta caattccctc ttacatcttt gaaaatcatt ttactgtgaa accaaaaggc 1832821 gtgtcagtgc gttttattta aagagttttc tgttgtttcc ccctcaacac gtatagatag 1832881 attgaaaatt ggcgtgaaaa ttcctataat gaagaaaatt aaacggggaa ataatggagg 1832941 tggcacgttg cctattaata taccaacaca cctgccggca aaacaggtgc ttgaaagtga 1833001 acatatattt gtaatggatg aaagcagagc atttcatcag gatatccggc cgcaaaaaat 1833061 tattatatta aatttgatgc cgaaaaaaat ccaaacagag actcagcttc tcagattgct 1833121 tggaaattcg cctttacagg ttcatttcac atttttaatc ccaagcacac acacgccgaa 1833181 aaatactgcg agagaacacc ttgacgaatt ttacacgact ttttccaata tccgtcacaa 1833241 gaggtttgac ggcatgatta tcaccggtgc gccgatcgag catttggcgt ttgaagaggt 1833301 ttcatattgg gaagagctca aggaaatcat ggagtggagc aaaacaaatg tcacttcaac 1833361 cttgcatatt tgctggggtg ctcaagcagg tttgtattac cattacggtg tggaaaaaat 1833421 tcaaatgccg aaaaaaatct tcggtgtgtt cgaacatacc gttctttcaa aacacgaaag 1833481 attggtaaga ggttttgacg agctatacta cgtgccgcat tcccggcata cagatataaa 1833541 tatggaacag cttcaagcag tgcccgagtt aaacattctt accgcatcaa aggaagccgg 1833601 ggtttgctta attgtgtcta aagacgaaaa acaagtcttt ttgacagggc accctgaata 1833661 tgatacaaat acgcttcttc aagagtatga aagagatttg gaacgaaacc tttctactgt 1833721 cgaggcccct aaacattatt ttgcaaaagg cagcaacgag ccagtgaatc gctggaaagc 1833781 gcatgccaca ttattgttta tgaattggct gaattattac gtttaccaag aaactcctta 1833841 tgaatgggac taatttttct ttttttagtg atacgctgag caaaaaatat gataaaatac 1833901 atctgattca gtctgcgtat aacaaaaatt taaaatactg gaatccaaat catttaaaat 1833961 tagcttaact ttttcactgc attaataatt cgattatgta tttgtgttat gtttatgtat 1834021 agacaataac tccttacgat gcatgaagct tgcttgttgt tgattacatt gaggtgaatt 1834081 tacttgaata ccaataaaag agtattaatt ttgactgcaa attacggaaa tggacatgtg 1834141 caggtagcca aaacacttta tgaacaatgt gtacggctcg gctttcagca tgtaacagtt 1834201 tctaatttgt accaagagtc aaatccgatt gtttcagagg taactcaata cctttattta 1834261 aaaagcttct caatcgggaa acagttttat cgtttgtttt attacggagt tgacaaaatc 1834321 tataataaac gtaaattcaa tatttacttt aaaatgggta ataaaagatt gggcgaactt 1834381 gtcgatgaac atcagcccga tattattatt aatacatttc cgatgatcgt cgtgccggaa 1834441 tacagacgcc gaactggaag agtcattcct accttcaacg ttatgactga tttttgtctt 1834501 cataaaattt gggttcacga aaacgtggat aaatattatg tggcgacaga ttacgtgaag 1834561 gaaaaactgc tggagatcgg cactcatcca agcaatgtaa aaatcacagg aattccaatc 1834621 aggccgcaat ttgaagaatc catgcctgtt ggcccgatat ataaaaagta caatctttca 1834681 ccaaacaaaa aagtgcttct gatcatggca ggtgctcacg gtgtattaaa gaacgtaaaa 1834741 gagctgtgcg aaaaccttgt caaggatgac caagtgcaag tagttgtcgt gtgcgggaaa 1834801 aatacggctt taaaagaatc tttgagtgcg cttgaagcgg aaaatggtga caaattaaaa 1834861 gttctgggct atgtggagcg cattgatgag ctatttcgga tcacagattg catgattacc 1834921 aagcccggcg gcattacttt gacagaagcc acagccattg gagtgcctgt cattctgtac 1834981 aaacccgtgc ctggccagga aaaagaaaat gcaaacttct ttgaagaccg cggagctgcc 1835041 atcgttgtga accgtcatga agagattctc gagtcagtca cttcccttct tgcagatgaa 1835101 gataccttgc atcgcatgaa gaaaaacatt aaggaccttc atttagcaaa ctcctctgaa 1835161 gtgattttag aggatatcct gaaggaatca gaaatgatga ccgccaaaca aaaagccaaa 1835221 gtgctatcgt aatggcgtac ttgagagcat acgaaaatcg tgtgctcttt ttatttatat 1835281 tcagccatca ataaaagcgg ttacattttt ttatggaact tgcccttctt ttgaaaaata 1835341 agccgtttcg caacttgacg ggtgctccca gatggtgtat agttgaacca tcatttaaca 1835401 atgaatcaaa gttagatgat gacaaaattt tttttagcac atgggtgcta cagtactagg 1835461 aggaattaag caatatgcaa aacggtaaag taaaatggtt caacaacgaa aaaggattcg 1835521 gcttcattga agttgaaggc ggagacgatg tatttgttca cttcacagct atcgaaggag 1835581 atggatacaa atcattagaa gaaggacaag aagtttcttt tgaaattgtc gaaggtaatc 1835641 gtggacctca agcttctaat gttgtaaaac tctaaactca atacatgatg atgagatgac 1835701 aaatagagga gaggcattcg cctctcctat ttgattttca tctggatttc aatcgccaaa 1835761 atgttttgtt tacacctctg ttcaatctct tcaacatact tttccattga tggttttcct 1835821 tttttcgcga tatcggccag ttcttctaaa tcactgtata tttctataaa tgttttgtga 1835881 aggatcaact tcaagtcttt atcatccata gctgcgttcc ccttctctat caagatacct 1835941 caaatagtaa aacggtccta tttattctgg ttcaatagtt atatcggctt atttttattt 1836001 tcttttctat tttggtacat aaatttcaaa aaaactctgc aaaataatgg cggaggtgtt 1836061 ttttgtgact tcagaatttc ataatgagga tcagaccggc tttacggata agcggcagct 1836121 ggaactagcg gtggaaacag cgcagaaaac aacaggagcc gcgacgagag gccaaagcaa 1836181 aacattagtc gactctgcat accaagccat tgaggatgct agagaactgt cacaatctga 1836241 agagctggca gctctcgatg atcctgaatt tgtaaagcag caacagcagc tgctagatga 1836301 cagcgagcat cagctggatg aattcaaaga ataaaaaccg cagcttctgc ggtttttatt 1836361 tttagtgatt ggttaagaca tctccgtatt gtttcaactt ttcaccaacc gtacatttat 1836421 tgatacaaaa tgaatgcgca taagttttgc caaattcttt gcgaaactgc ttcttaataa 1836481 aacagtcctt gcaatattca tcgtgcagtt ctgtcagttc tttaaagatc attttcttat 1836541 ccaatatcgt catctccgtt acggtctaat ttcgtgtggc tttctacgaa ttgatgggat 1836601 agaatttttt tagcgaggcc gtcagcttcc tgattgtctt ttcgttgtat tgtttcgtag 1836661 gttggagtaa gcttcagcga ttcaaggagt gcttctattt tgtccagcca ttcattatga 1836721 gatggatcat aacaaggcca gctgccgtca agctgattca gcacaacaag cgagtcccct 1836781 ttgattgtaa ttgaatttct gcttgcccca agctctctta cttctcttat tgcttcataa 1836841 agcgctgcgt attcagcttc attattggtt ttcagccgga agcttttatt ttttctcaag 1836901 cgatgccggg ttcctcccaa tgaataatag atgacgatcc cgagaccggc cagttcgctc 1836961 tctttatcga aactgccgtc aaaataaaca gtaatgtcat caggctcttg agcaagctcc 1837021 tctgtcagct tttccaattc cttcagcgtc cagctgccgc ctttctcgtc ttcgaactct 1837081 agctccttca tgtatggaaa acggccaagt tctctggcga acgtacgtgc ctgctgtgct 1837141 gtcagccagt cttcgctaaa aaatgagacg gatcccgttc cttttgcttc tattttcaaa 1837201 tgcggtctga gcttcattac aatcacctta ccattcatta gttgccgggc ttatgctata 1837261 atcaaaccaa tcttaccccg gaaaggaagc tttttcatct tgtttaataa ttcgttttgg 1837321 atcttttttg cgatcattca ttttatcatt gttcttttat tttataaagg atttggcaaa 1837381 atgggactgt ttgtttggat cggttttgcg acagtctgcg ccaacctcca agtcgtcaaa 1837441 acagtcgaac tgtttggctt aacagcgaca ctcgggaatg tgatgtatgg cacaatcttt 1837501 tttgcgacag atgtgctgaa tgaaaaatac ggaccagctg aagccagaaa agcggtatgg 1837561 ctcggattct caacgctcct gacgctgaca tttgtcatgc agggcgtgct gcttttcgaa 1837621 ccggcttcca gcgacatatc acaaacagcg ctggaaacga tcttcggatt ccttccgcga 1837681 gttgcgttag gaagtctgct tgcctttatc ttcagccaaa cgctggatgt ttatgtatat 1837741 tcggcaatta gaaggatatt tccttctgat cggcttttat ggctcagaaa cggcggcagt 1837801 acagcagtca gccagttgtt tgatacattc atattcactg cagtcgcctt tctcggcatt 1837861 tatccggcag acgtgtggct tcatattttt atttctacat atttgattaa gtttgcggta 1837921 tctttaattt cattgcctta tgcctatgca gccaaaaaaa tgatacctaa tgatgaaagg 1837981 agttcataat gcctacagaa atatatgtag acggcgcaag cgccggtaat ccagggcctt 1838041 ccggtatcgg catttttatc aaacatgagg gaaaagcaga atctttctct attccaatcg 1838101 gagtgcatac aaaccaggaa gcggaatttc ttgcattaat tgaagggatg aagctatgtg 1838161 caacgcgcgg gtatcaatca gtttcctttc gaaccgattc agatattgtg gaacgcgcca 1838221 ctgagcttga aatggttaaa aatataacgt ttcaaccgtt tgtagaagag atcatccgat 1838281 taaaagcggc attccctctt tttttcatca aatggatacc gggcaagcaa aaccaaaaag 1838341 ccgatcttct ggcaaaagaa gcgattcggc tgaatgaaaa gaattaaatc ttgatcattg 1838401 gttcatccta atggcgaggt gaactaacat gaaaaagaaa gataaaggcc ggctgaccgg 1838461 cggtgttact ccgcaaggcg acctggaagg caatacacat aatgacccta aaacagagct 1838521 tgaggagaga gcaaaaaaaa gcaatacaaa acgctagaga ggatctaaac gatctctcta 1838581 gcgttcagct tttcaagcat acgctcaatt cctttaattt ggtggcggcg aagcatgtca 1838641 gccgcctgct ccatttgcaa agtaaataaa gcgtctttca gtgtgcaggc cagcggcact 1838701 gagcaatgga tttccgcaag cttcctcgac atctccaaat cgcttaaacc ttgctgaatt 1838761 tttccctgct gtccttttgg aagaagagaa agattttcca ataaacggtc aatcgtttcg 1838821 tattcacgaa tcagtttgta ggctgttttt tctccaatgc ctttgactcc gggatagtta 1838881 tcactggaat cacccataag cgctttaata tcaatcaaag ccttcggcat tacgcctgtt 1838941 tcttcataaa aagtctcttt tgtatagact ttataatttc cgattccttt ttgaagcaaa 1839001 gcaacgctta ctttatccgt taacagctga agtaaatctc tgtcccctgt taccaccgta 1839061 atgtccgctt cattcgcaaa taaatcggca agagtaccga tacagtcatc cgcttcatag 1839121 ccggcaaagc caatattcat gattccaagc tctgcggctg cttcctttgc caaatcaaac 1839181 tgcggaatca gctccacagg cggcgcgctg cggttggcct tataatcttg gaacaagtca 1839241 tttcggtacg ttttgctccc catgtcccag cagcagacga cgtgtgtcgg ctggaatgtt 1839301 tccacagctg taatcaaatg ctttaaaaag ccgttgacgc cgttcgtcgg caccccgctg 1839361 tcatttatca taaagttgcg atgtacggcc gtggcaaaaa aggcccggaa taaaagagcc 1839421 atgccgtcaa ccagcaatag tttattatta ttcatcaaat aactcccttt tctttcattc 1839481 cttctatttt atcataaagc agcccaaaaa taaaaaacag tatctcttta attagagata 1839541 ctgtttgaat atttatcaat cgttgtgtct tttgttgctg gcgatcagct tttcagcttc 1839601 gcgtcctgcg taagagtcaa aatgggtttg aaatccgttt ttctttttgg cgttgttatt 1839661 cgcctgtgca tttctgtttc cgagctttgt tctgcccaac atgaatcccc ccttacgtcg 1839721 gatgcatata gtatatgctt ccggcaggag gttcactcgc gacaggatca tccagcttac 1839781 atgcggctta cgtattctct gaccatttct tttgatacaa gccgtcttgt cgggacgatg 1839841 ccttttttag cgagctgatt catttgctcg gtaatttcat taattgcatc tgtagtataa 1839901 ggctcatcgt ttctgcattt agcaacagct tcttcaatcg ccaattcacg catattttca 1839961 agacgcataa atgctttgat atgctcgtgc tgttttgatg aatgtgctga aattgcttta 1840021 tgtacctctg acattaatcg ttcatctcgc ttttttctat ttagtctatc atgacttgaa 1840081 atacaagcca actgaatttt acatttttat tgtattgtct gaatttttcc aggagatgca 1840141 cgcctgatac gccatttcaa tctctttcgc atgttcccct tccgcatatc ctcttaaata 1840201 tgtctctttt tgatccgtta tttgcgcgat tgctttttca cccatatctt cctgtaagcg 1840261 tctgaggtga gcagtgtaat gagatatcag gctttcttct tcatttttta tccatgcctc 1840321 tgtgattttc gtaagtttca tccgtacagc ttcgataaag gtcgcttttc ctttctgctc 1840381 aaaaaactgc ttcggtgatt tgatctcttt tagttcctgc tcaaaagcac gttcttctat 1840441 ttccggttca acttccttca actgtatgcc gttcgaatgc tgatcacccg cataaacgga 1840501 aaaataaccg tcctcgttta atgttttttg aaaatgatcc agccattctt cattgatatg 1840561 ccgttcgatg aaaccgctca tgcgaacatc aagcgttttg atttcctgaa tatattcaaa 1840621 tagatattca tgtaaggctg ttgtcatcgc tttactgacg ttctttttcc aatccccgtt 1840681 ttgcagcccg ggatgaaatg ccgattttaa taaatcattt gcaaaatatg ataatcgctg 1840741 tgcaatgtga tatagctgct ctcttgtatc tttttttact ttttcaatga tggtttttga 1840801 gttccgccgt ttctcgatat cggccgctgt ccgctcaaat gacagcataa ggcactgttt 1840861 ctgcgcttcc ttctcttctc gggactgatg ctgggattgg tgaagctgaa aaacagtttc 1840921 gcatagtttg tctgcctccg aactgagctg cgctgctgac gcttttttta catccacttc 1840981 gataaaccgg tctaagtgtt ttcttacttt cgagaactga ttataaaatg actccggttt 1841041 tcccaccagt tcctccttac ttgatacggt aaagagctgc ggctcataaa ccccttcttt 1841101 tacaagctct gcgctgacat aatcggtcac tgtttcgagc tctgttttat cttttgcaag 1841161 gtctgcagca ttaataataa aaaacatttt atccatgctg agcgattctt tcacaagtcc 1841221 aagctttcgc aaaaatgaac ggtctccttt tgaaaaagag tgctgataat aagtcatata 1841281 aaaaaatgca tcagcatctt tgatatattg gaatgccagt tctgtatgcc gtttattcat 1841341 gctgctcgcg ccgggtgtat caacgatcgt aatccctttt tcagtgagcg ggcatgtata 1841401 gtagaccgtt acctctttca cagcacaggc cgttgtttcc tctgctacat acggctttaa 1841461 ttcagagagc ggaatcgtta atttcttctg ttcctgtata tactgctgat acttctcgta 1841521 tgcaagcagg aaattgctga tcaatttcac gtgttcttcc tgcagcctgt tttttttgac 1841581 tgccttttcc cacttctctg tgaaggaacg gcctgccggc tcctttggta ttccggtgag 1841641 ctgcaaaatt tcagccgtta agtcatcctc tgtcttaaac actacattcg ctgttttgtt 1841701 taagttgcca ttgattggct ttgtgatctt gttaattgtc gctgtggttg gcgttggtga 1841761 ggatggcagc actctttcgc cgacaagcgc attggcaaat gatgatttcc ccgagctaaa 1841821 gcctccaaaa agagcgagtg taaatttccg ttcctcaagc cttttcaccc tttcacgaaa 1841881 cgctgaagtt tgctttaaca acatgctgca ttcgcctaaa atgtcagaca aagtgtaaaa 1841941 gcgtttgatt tggtcttgaa gcggcatttc ttgttccatt ttgatttctg atttcggcat 1842001 cggctgcgcc gtcagctggc ttcggccttg tttctgctct ggagccgcca ctcttgtttt 1842061 cttcgattta aaccattctg tgtctatatg cattgggcat gcggactctt cttcccaaat 1842121 ggcccacagg cgatcggttt tctctcgggc attattctct aaacgtgcct gttcttgaag 1842181 aaagacaagt ttttctgatt cttggacgag ccggtcgtta attgtttgca catctttgga 1842241 aacacgctct ttcaccatag cggagagcac ctttatgatg tctgcggctt ctcttttcgc 1842301 ctctttccgg atgagctctg ccaagtcttt tgtatattgc aatacatatt cagaggaaaa 1842361 ggctgcacca tgcttgaccg cgtgttcaat gatgcttata tcaagcggtg tgcgataggc 1842421 ctgaatcagc ttttcacttt cagcggtata gacatcaaat accttggcga gtttatgaag 1842481 cgtgtctatc atatgccaat ccgcttcggc ctctgttcgt tttgccacat cagagaaaaa 1842541 agcattccgc cttttatctc tttcctgtgc agttttcgct ttagaaaaga aaaagccggt 1842601 tttaaaggaa ggctcttgtg attctaaaaa tgcagccgcc aattcacgca tttcaaaagg 1842661 cgtcaggttg gcgtttttta aaatacgatt gatttcttcc tgcatcctct tctctgcctc 1842721 agtcatttgt ttttcggcct catccaattg atcacgcagc gattggacca gtccagtatg 1842781 gatattaagc tgttcagcga aactcggagc gcctgtttcg tctttcttca gcatttccgt 1842841 atgttccttt agcagattac ggactttttg ttcggttaaa gcctgcatat tgctttttga 1842901 ttgctgttct attctgctta actcttctct cagggccccc atctgattga acgggtgatc 1842961 cggttctgtt actgatgtaa aatagagcgc ttcccttgaa atcccttcat tgcaaagcat 1843021 ctcctctacc tgcgcttgat agtctccaaa tttcgtctcc gtctcatcat ggcggtcaat 1843081 ttgattgacg ataaaataca cattcggaat gctttctttt attgatctga gaaactttac 1843141 attttcctca gcgtgcacgt gattatagtg aacgacgtaa aacagcgcat ccgcttggtg 1843201 aagaatagaa gcagccgata gaaaatgcgc atcatctgtt gaatctatcc ctggagtatc 1843261 aatatacgca accccggaat cgatctcagt atacctgtca aaaatttcga cgctttcaat 1843321 ctgttccccg tctttacaat attgctgcac cttgtctttc tggtaagtcc cttccagctc 1843381 agcacacgct ccgtctgttg tatgaagccg aactcgcttt tccccgtttc tgatcacaac 1843441 aaggttagcg cttgtcggaa tcgggcttgt cggcaaaata ttctccatta acaggcagtt 1843501 cagcagtgac gatttccccg ctgaataatg cccggtaaac gcgatataaa cctcttcatc 1843561 agccgctttt ttcatgaccg cagccagttt agcagccctt tgttcatctt gattctcaat 1843621 aaattgctta taaagttccc cggttttatg caaaagctct tttctgtttt gatctgtcat 1843681 aagtctgaac ccctttgtgc cgtttcaatt gtgaaccttt ttcgaaagat ctgaattcat 1843741 tcccttttca ttttacacaa gaataaacca aatttcttta ggagaataga aaaaagccgc 1843801 cattacggca gcttctataa aagaaaatct gcaactttta caagttccag attcatcaaa 1843861 cagatttatt agagattcct tttaatacaa aaccaattaa tacactatat gtacaaaccg 1843921 ctccaagcaa aaacagcatt gtcatttgct tcaccatcct gattgagaat ctttttcaaa 1843981 cccattttaa catggttgag aatgattttc aatcgctatt ttacgctgta ttcctgtaat 1844041 gctttgtctt ctgcgcgaat tctgacgctt aacaacacgg cattgaaaat ggaaaacaga 1844101 cacatggtga cgtatgcttg ataaagcagc ggaatcagca aaatttcgag gataacaacg 1844161 gcatagtttg gatgtttcat ccatttatat ggaccttttt ttacaagctc tacacctgga 1844221 acaacaagga ttttcgtatt ccaatatgct cctaaggaac aaagcgccca ataccgtacg 1844281 atctgtacgc ttaaaatcac tgcagcgata ccgagccacc agctggacgg ctgtttattc 1844341 atcagcagca cctcggcaat taaggacagg aaaaaaagga tatgcatcgt aatgatatac 1844401 ggatagtggc tctcgccaaa ttcaattgct ccttgcttct ttaccttttg ttcgttttgc 1844461 ctggccactg ccatttctgc tgctctttga acaatgagaa tggcgatcaa caaccaaaac 1844521 atgagtcagg cccccttttc ccagctgaat aatagcaact ctgatgagaa acccggccct 1844581 aatgcgccaa tcagtcctcg ttcagcttcc tttttatgtc cgttctgcag atggtctttg 1844641 atcacataca agattgtggc tgaagacata tttccgtgct tttgcaaaat gctttgcgca 1844701 gatgaaagct tttctgacga cagcccgaga cttttgatgt atgcatcgat cacttttttt 1844761 ccgcctggat gcgccaaaaa aacactgata tcatggaatg acagcttatg tttgtccaaa 1844821 aaaatctgta catttgtttt gagccatttt tccaccaagg tcggaatgtc tcgtgagaaa 1844881 atgactttga atccttgatc ggtaaagtcc cagcccatga catcttctga ttgtttcatc 1844941 aaaacagatt gggcgtccat tatcttcggc gcaagcttca gctttgacac cctgcggtcc 1845001 gccttctctc cgcataataa agctgcggca atgccgtcac caaaaagcga ggtgccgatc 1845061 agattgcttt ttgttttatc ttccggctgg aatgtcaggc tgcacagctc ggcagaaatg 1845121 acaagcacaa aagcctcagg atacgctttg cagtattcgg ctgcacgcgc aagtccgctg 1845181 gctcctcctg cacagccaag cccccaaatc ggaatccgct tcgtatatgg agaaaacgga 1845241 agttcattca taagccgcgc ctcgatactc ggtgtggaaa gacctgtact ggagacgaaa 1845301 aaaacagctt ccactttctc ataaggaatg gcttcttgaa aaaattccgg atgagagagg 1845361 cactcacgaa cagccgctct gctgtgttta agtgtttctt ctatgtatat ttgatttttt 1845421 tcttcaaagc tgtgcccctc tttataccat tcaatcggct taacaaactg tctcgaatgg 1845481 atttgcccgt ttttaaagga ggataacagc ctgtcaatat ccttaaaaga atgctgaaac 1845541 atatagcggg cgaactcggc cgctttctct tggtttacat tatacgcagg aagacttgtt 1845601 ccaatggata aaataaacgc catgcgatca cctctttgca tacattgtgc cgcaacaatc 1845661 ttttttatat gcaaaaaaaa ctccgccgcg gcggagttag actgctgttt tttgttcagc 1845721 gaggtcagct tcttgttcta tttttttagc tttagaaaaa acgttatata caatatttaa 1845781 gacgactgca gtaaagctgc ccgccacaat gccattcgtt gtaagcagcg ttaaggcact 1845841 cggaagctgt ttgaaaatat ccggcacaac ggtcacaccg agccccaatc ccactgagca 1845901 agcaacaatc agcagatttt cctgtttcgc aaaatcaatg cggctgagca ttttaattcc 1845961 gtaagcaatc accattccaa acatcgccac cattgcaccg cccaaaacag cggatggaat 1846021 aatagtcgtg aaagcagcga tctttggaaa cagcccaaat gccattagga tcacacctgt 1846081 gaccacaatg acggcatttt ttttgatccc tgtgagctga acaagcccga cattttgaga 1846141 gaatgccgtg taaggaaaag cgttaaaaat accgcccaga agcacagcca gtccttcagc 1846201 tcgatagcct ttagacaaat ctatctctgt caaacggcgg tttgtcaggt cacctaaagc 1846261 aaagtaaaca ccagttgact ccacaaggct gacaattgca acgatggaca tcgtaatgat 1846321 aggcgctgcg tgaaaagacg gcgctccgaa gtaaaatggc tgaatcattt gaacaactgc 1846381 cgcgtccgaa acattatcaa attgaacttt tcccataaaa tatgcgatga aggtgccaat 1846441 caaaataccg atcaaaatcg agacggactt gataaagcct tttgtaaaac ggtatagaag 1846501 cacaatgata ctcaacacgg taaaagcaag tgcaagattg gagagatctc cgaaatctgc 1846561 acttccttct ccgccggcca tgttattcat ggcaaccggc atcagtgtaa taccgataat 1846621 cgtaacaaca gagcctgtca cgaccggcgg aaaaaacgat acgagctttc caaagaaaaa 1846681 tgaaataaga atgacaagaa tgcctgaagc gataatgctg ccgtaaactg ttgaaacccc 1846741 atattcagat ccaatcgcta tcatcggcga tacagctgta aaggtacagc caagcactac 1846801 cggaagcccg atcccaaaaa atcggttgct ccacacttgc agaagtgtag ccacaccgca 1846861 cataaaaata tcaatcgata ctaagtaagt cagctgctcg acagtcagtc ccattgcttt 1846921 tccgacaatc agaggaacga caatggcgcc ggcatacatg gcaagaacat gctgaatccc 1846981 taaagacagc gttttgccga atccatttct catgaatgaa cctcctgtac gaaggacact 1847041 tttccttctt ctaaagactg aattcttgcc aaagattcca ctcggtagcc cagttttaca 1847101 agttcatctc ttcccggctg aaatgacttt tcaataacaa tgccgattcc cgcaatagaa 1847161 gctcccgctt gcttcacaat cgacacaagc ccgtgcgctg cctgtccatt tgccaaaaaa 1847221 tcatcgataa tcagcacatg atcctgatcc gacaggtggg tcccagacac tgcgatttgg 1847281 ctttctgttt gcttcgtaaa ggaataaaca gacgctgtca gcaagttgtc ggtgagtgtt 1847341 aacgatttat gctttctcgc gaagacaact ggcacaccca gcttcaagcc cgtcattaca 1847401 gcgggagcga tacctgatga ttcgattgtc acaattttgg taataccgtc ttttgcaaac 1847461 ctagacgcaa attcatcacc aattctctgc ataagcagcg gatcaatttg gtgattcaaa 1847521 aaagaatcca ctttcaatac ctgatcagat aatacgacgc cttcttcctc tattttccgt 1847581 ttcagtgctt ccatcctgtc tacctccgtt atgagaataa aaaaagcatt gcccgctcaa 1847641 ataaagagca agcaatgctg atatcacaaa aaaccgtaca cgtgcggttc cattgctcac 1847701 ccatagtcgg acatttacgg tgcccggtag aaacttgcgt gccatatcca cgcgattata 1847761 tgagtgttcc tattatattg taataaatta tatcaagatt ctaatctctt gcataggctg 1847821 aaaataaaaa ttcccgaact ttaattttgt ttttttagat atcattcgta tttcaagggg 1847881 attcgatata aaagagtctg acgaccgcgc cgccaggctt ttgattataa cagatagaga 1847941 tttgaatatt tgtttgataa ataatcaatt aaatagcgaa cattcagctc ttctcctgtt 1848001 gcatctttaa taatgtctaa cggctttttc cgttttccgt gaatgtgcac cttttccgtc 1848061 agccattgct ttatcggatg gaactctcct ctttccaaga gagcgtcaaa ttcagggaga 1848121 tcctcaagca ttttttgttt cagctgagcc gcatacatgt agccgagcgc ataggatggg 1848181 aagtagccga aatctccacc tgcccaatgg acgtcctgta aaatcccctc tgcgtcggtc 1848241 tgcggtgtaa tccctaaata atcctggtat ttttgattcc aaagcgacgg cagatcttcc 1848301 acagacactt cattgctgaa aatcgctttt tcaatttcat aacggatgat gatatgaaga 1848361 ggatacgtca attcatccgc ttcgaccctg ataaatgaag gttttgattc attgattgcc 1848421 cggacaaaat catccaggga gatgtccttg aactgtacag gtgatgcctc ttgaatcttc 1848481 ttatagtacg gagtccaaaa atgcttgttg cggccgataa aattctcgta aaataatgat 1848541 tgcgattcat gaattcccat cgatgcgccg tctgacaagt tcgtgccact gagtgcttca 1848601 tcaatatttt gctcgtaaat cgcgtgcccg cactcatgaa tggtcccaaa gatcgccgtc 1848661 cggaaatctt tttcatcata tctcgtcgtg acccgaacgt ctccccgatt cagcgtagtt 1848721 gcaaacggat gaacggtttc atcaagtctt ccgccatcaa aatcgtagcc aagctcctgt 1848781 aaaaaataca gactgagctc tttttgcttt tctttcggga acgcttttgt aataaagctt 1848841 gtatctggtt tatttccgga agctgtcacc tgtttaacaa gagggataat cgcttccttc 1848901 agctcagcaa acaactgatc aagcaccttt accgtgacgc cgggctcaaa caaatcaagc 1848961 aatgcatcat aaggatgctc ttgatatccc caatacgtaa taaaacgttt attgaattca 1849021 atcagctgtt ctaaataagg agaaaacaag ctgaaatcag attttccttt cgcttcctcc 1849081 cacgctgttt ctgcctttga acacagaatc acgtattctt tgtattcagc ctcagggatt 1849141 ttcttattct cttcatactc ttttttcgcc agttccactg cttttttcgt atcttccgac 1849201 aagtcatcaa atcgttcata caggacatcg ataagctcct tcattcgatc tgatgtttgg 1849261 atattgaata tatctgttga aagctggccg atactttcgg cacgatcctc tgagccattt 1849321 ttcggcgcgc ctgttctgga gtcccagtgc attaacgcaa ctgcttcgct gtaatgtgag 1849381 attcttttta aaagatcaaa aaattctttt tcatatgtat gtatctccat atccattccc 1849441 tccctattct agccgttcca ttacaggcta atggaagggg gtatgaaagt caaattgttt 1849501 gtataaaagg ctgccggtat gttttgtggc agccttttta ttcagttgat cgtcatttga 1849561 ttttttggcg gaggtgttct ccgctttttc tgcttgattt ttttatctac ccacactgtt 1849621 gccagcgggg ttaagagcga ggtgacaata acgcttgtcg cgataattgc agttgccgac 1849681 tcagcaactg gcgcaaatga ggcattcgct tccgctaatg catatggcac ggctacagcc 1849741 gcccctgccg tagaagaagc ggccactccc gcgacaccat ctccccgcgc aataaaacga 1849801 tcaagcaaaa acaaagaact gcccgataaa atgacgacag aaactccgat aaaaatgccg 1849861 agcagccctg attggatcag cattccaaaa ttcaaggtat tgccgagcga aaaggcgaaa 1849921 aatggaatga tcgccggcac aaccttgctg aataagtctc tgagatcatg atccagattt 1849981 ccaagtatac atccaagtaa aaacgggatg actgtcgctg ccagcgtttc ccatgggaat 1850041 gcggcaagtc ccgtcacacc aaacgtcacc atggtcataa aaggaccaga ttctgtactg 1850101 ataaaggcga aagcgcccgc atcctctttt cttcccatgt gattcatgag cgccaaatac 1850161 agtccgccgt tcgtttcatt cattaccgcg acaattgcta aaacagaaag gcctgcaaaa 1850221 aagccggatt gtatgccatc gtcaggtata aattgcgctg cgatcacgcc gagcagcgcc 1850281 gcaaatccga tcttccccaa taataacgtg attccttttc ttgcgatata gcctgaagaa 1850341 cgaaaatcaa tcgttgctcc tacgcaaaag ataaaaacac ccagtatcgg cagcgttccg 1850401 gtaatcaaag cacccgtaaa ccctccaaag aactccgctg ttccaggcgc aaacgtgttg 1850461 agcgccgctc caagaaatag cggaataatc atcattccgc caggtacccg ttcaattgtc 1850521 gccttgattt tcatattgtg gattctccca tcctccggtt atgaaaaaac aattccactt 1850581 acacttggaa aacagcctgc aaatcctctt ttgaacagct gcccaactgg ctgccgactc 1850641 cgacggcgcc agctccggct ctaagccaat caggcacttc agacggatgt atcccgcctg 1850701 tcggaataaa ggtcacctgc gggaaaggac ccgctaaatt tttcataaac ggaatgccaa 1850761 acacaccgct tgggaacagc tttaatgtcg taaaaccgaa tgtcagcgct tccataattt 1850821 cgctcggagt caagacgccg gggatataat gtgtctttac aaaagataga tgttcagcaa 1850881 gatcagctga aaaacccgga ctgacaataa actgcgcgcc agccttagca gcttccccag 1850941 cttgctgcgc gctgatgacc gtacccgcgc caattaaaat atcttcccta ttacggaagg 1851001 attcgataat atctgatgcc ccgggggtcg tatacgtcac ttcaactgca cgaatccctt 1851061 tatctaataa actctcaatc tgctgacagg cctcctgctt atcctttgaa cgaatgactg 1851121 caatcagctt tgcttctttc agacggtttt caacgacttt ggactccata ttaataatcc 1851181 cctttctttt ggtgaaccgt tctttgagca gataaaaaag aagctaattt ctccctggtc 1851241 ggcaaaccgt ccatatcccc cggtgcctgc acttgcaaag cgccaatcgc atttcccctt 1851301 tgcaccgcat ccttgtacga caaaccgtct aggataccgc tgattacacc gactgcaaat 1851361 ccgtctccgg cgccgaccgt atcaaccacc cggtcgaccc ggcagccttc tagaaatcct 1851421 tcacttgtcc ccgttttaaa gtaagcgcct tcttttccaa gtttaatagc aacaaagctg 1851481 gcaccttttt tcaaataata gtcggcaatg ccttcaggtg ttttttctcc ggtcaatagc 1851541 tctccctctg cgatacccgg gaaaaaccag tctgcaagcc cagccagatc attgattgtg 1851601 tgtaccattg ttgcttgatc aggccaaagc gaaggtctta cattagggtc gaatgaaatg 1851661 gtcttccctg cgtttctcat gtcgttcatg acatgatacg tgaagtcttt catctcggct 1851721 gataaagcag gcggaatacc tgtcacatgc aaatggcctg cgcattgaaa ataatctctc 1851781 ggatattcag ctgtagttaa tgtgcttgca gctgagtttt tcctatagta ggtaacttgc 1851841 gggtcgcctt ctttcacttt tgacttcagc agcagcccgg tgggattttc gtcctgcgag 1851901 cggatcacgc gggacacatc cactccctct tttttaagct cttgtaaaat aaacgttccg 1851961 agctgatcat tgccgacctt gctcatccat cccattcgaa atccgagtct ggcaaggccg 1852021 caggcgacat tgctttctgc tccggcaagc cctttagaaa aagtggatac ttcatgaagg 1852081 cctccatact catttgcata aaacatggcc attgattccc cgaatgtcac cgcatcaagc 1852141 ttcatctctt cccaacctcc tcttagttga gggcacctag gattaaagtg actttctcat 1852201 gatgactttt gcctctaatt caatggtttg aggcgctcct ttgtcacctt caatcctttt 1852261 taatacacgt tccatcgccg tcctgcccat atcatgtgac ggctgggcga tcgttgtaat 1852321 gcctggaccg atcagtttgt accactccgt atcatcgaat cctgcaatcc ctatatcttg 1852381 agggatgcgc aggccaagct cttccataca gctgatgatt ttcagcataa tcaagccatt 1852441 caaagccaga atcgcttttt tttgctccgg catttccttg tgaaaagaac gaagctccgc 1852501 cttaagctgc tccttgtcct ttacgtcaat ttcatgcaat ctgacaagcc cgttcacatt 1852561 ttgaaccgaa gccatttcct gatacacagc tgctctttct gcacgagggc tgatagagga 1852621 aatcggttcg gtaaacagcg cgacatcagt ataccctttg ctgtacacct tctgaagaat 1852681 ctcttttgtg atccatctgt tgtcagtcgt tacggtatcc agtttcagat ccggcagttt 1852741 ccggtcaatt aagattgttg gaatttgctg ttcagcaaaa gcgcggagta catccttgtt 1852801 ttcccctgtt gcgtttaaaa tcaagccctc aaccgaatgg gcttctagct ttaagagcat 1852861 ttcccgctct ttttcaggac tgttatctgt gttgcacacc ataatgctgt atccatattg 1852921 atcacaaacc tcttcgactc ccctgaaagc agcgaccgaa aaaggatttg taatgtcagc 1852981 cacaacaaat ccgattaact tgcttttttt tattttcaaa ccttgtgcca ttttactcgg 1853041 ccgataattc aattctgcga ttgccttttt aatgtttttc actttttcag gagaaatcgc 1853101 gtcaattttt ccgttaatat agcgggaaac tgtcgatttc gaaactcctg cacattcagc 1853161 tacgtctttg atggttgtat ggcctgttgt tttctttttc attcaagtgc tcctgtatct 1853221 catatatttg aaaccgattt caaaaccgtt acaacaaaag aataccataa ttttaaaatt 1853281 tgggaagagt ttttttaata atatgtcaat tcattatttt ttcgttgact cttttcacta 1853341 tttatcctaa aattttcttt gaaaccgtta ccaaaatatt ttcattcaag tgatgctgaa 1853401 atcctaacca agggggaaat ataatggaaa atcgttattc tgtacatcct gaacaagtaa 1853461 aacgctttac aacagaggag cttcgcagtc atttcttaat ggattcttta tttacagaaa 1853521 acaaacttac gatgtattac tcacatgaag accgggttgt catcggcgga gcggctccag 1853581 ggcaaagtga actgaagctt gatgcaggtg attttctaaa aacagacttc tttttggaac 1853641 ggcgtgaaat cgggattatt aatgtcggcc agcctggtgc cgttagagtc ggcgatgatg 1853701 aatatgtgct tcaaacaaag gattttctct atattggaat gggcaatcag gatgtatcgt 1853761 tttcaagcct gaacggggaa aaagcgaagt tttacttcgt ctccgcttgc gcccacaaaa 1853821 gctatccgac acaaaaagcc gccctatctg aactgacacc ggaccgcctt ggtgatgatg 1853881 cagcgtctaa tgtcagaagt ctgtacaaag tcattcatca ggatggcatt aaaagctgtc 1853941 agctgatgat gggaataacg atgttagatc aaaacaacaa ctggaatacc atgccagcac 1854001 acgttcatga ccgtcggatg gaggcttatc tttatctgga tcttgaaaag gactcaaagg 1854061 tatttcattt catgggccag ccggacgaaa cacgccatct tgttgttgga aatgagcagg 1854121 ctgtcctttc tcccgcttgg tctattcatt ctggcgcagg aacatcaaac tatagctttg 1854181 tgtgggcgat ggctggagaa aattacacat ttacggacat ggatctcatt ccaatggatg 1854241 ggctgaaata agatgggtta tctacatgac gccttttcat taaaaggaaa aacagcgctg 1854301 gtgacaggcc cgggaacagg gatcggtcaa ggaatagcca aagccctagc cggggctggc 1854361 gctgatatta tcggcacatc acatacaagc agtctgtctg aaacacagca gcttgtggaa 1854421 caggaaggcc ggatatttac atcttttaca ttggacatga gcaagccgga agcgataaag 1854481 gattctgcag ctgagctgtt tgaaaacagg cagatcgaca tccttgtcaa taatgccggc 1854541 attattcatc gggaaaaagc ggaagatttt ccagaagaga actggcagca cgtactgaat 1854601 gtcaatctaa acagcctgtt tattctgaca cagcttgctg gcaggcacat gctgaaaaga 1854661 ggtcatggaa agattattaa tattgcctct ctcctgtctt ttcaaggcgg catcctcgtt 1854721 ccggcttaca ccgcgagcaa acacgctgtt gccggtttga caaaatcatt tgcaaatgag 1854781 tgggcagcgt caggtattca ggtcaacgca atcgccccag gctatatttc tactgcgaat 1854841 acaaagccta ttcgggatga cgaaaagcga aatgaggaca ttttaaagag aattcctgcc 1854901 ggccgctggg gccaagcgga tgatatcggg gggactgcag tctttttggc atcacgtgct 1854961 tcagattatg taaatggaca tattttagca gttgatggcg gctggctatc ccgctgacaa 1855021 ataaaaaagc tgacgaacga tcgtcagctt ttttccatta catcatgtgc ggttcaacag 1855081 gcaagacctt tttgacctca tcaatgatgc gttcattttc tccgccagcg taaatgtgaa 1855141 tcgagccgct gtcttgattc gagcgaatca ggcgcccgat gccctgccgt acacgtaaca 1855201 acatatatgg cagatcaact tcttcgaacg gatctttttt cgctccgttg cgcttcgctg 1855261 taaatacagg atcgtgtggc gggaacggta atgaccaaat ggtaacattc ttcaatgcgt 1855321 caccgggaat gtcgagtcct tcccataagt gaactgaaca aagtactgtt tcttcttcct 1855381 cttggaattt ctctactaag ctgctgattt cctcatcacc ttcgaagaaa attggatacg 1855441 gcagctccca tgccgccgac agctctttaa actcgtttaa ttcttcaaaa gaagggaaaa 1855501 gcaccagcgt tcttcctttg tatcgtttga ttgtttcaat cgtttcagcc gttttttgtt 1855561 cagcgtccat atctgttttt gcgtatagat taatactcat ttgctcgtca taatcataag 1855621 gggaatcaac agttaatgac aaataatcat gaatcccaag actgtcggca atataatcaa 1855681 acgaaccgcc ttctgacagc gtagcagaag aaaagatata aggaattttc ttagaaaaca 1855741 ctttttcgcc aagtacttct gctaccgttc tcggcatcac gacaaaggtt gattctgctt 1855801 cctttttctc cagccagctg atcgcatcct tttgatatag agataatgaa tacgccattt 1855861 gttcaacata ttcttccact actgacagtt cgtattgatc aatcgtatac atttcagact 1855921 caaatacaag tgcctcaccg attttatcaa gtaaacggca aagctcgtcc gccgcctttt 1855981 tgacacgatg gtcatttttt atttctaaac ggtgtgaacc ggctacttcc tttgattctt 1856041 cagaaagaac atagaaaaat tcgtcgtttg cgagaagcgc atcttcaatc aattctgcaa 1856101 actcttctct gatgtcattt tgcagcaatc gttctaaaaa caattcaaga gtagactgct 1856161 tcactctata ggttagcgct ttttgcgcag caaactctaa caagtgcccc tcatcaaata 1856221 caactgcact atgatcaggc aagagcggca gctggccctc tcgtttgcgt gattcttccg 1856281 tccacacatg ctccatataa aaatcatggg aacaaatgat taagtccgtt gacttgcggt 1856341 agtaatctct ggaaagtgtc agaccgcatc tgtgtctcat atcacaagtc agacagtcct 1856401 gaaacgagtc gtagcttacg tcagaccact cttcattcga tagatttgcg tactgcttac 1856461 ggtcgccata cggataaaag cgctgcatcg cctgggactc gtggacaaat gacggtaacg 1856521 actcataaag atccagccat ttatcatcat cagaacgctg cattgttttt tcaagcttct 1856581 tcaagcataa atattgctca tgtgattttg acagccttgt atcaattttc agatcaagat 1856641 gctcagccag cttagaaata tcgccctctt ttttcaccag ctgttcaatt aatgtttcat 1856701 ccgcacaagc gatgatggca ggtttgccga cataccttgc atagctgatt gcaaaaagaa 1856761 gatataccag cgttttcccc gttcccactc cagcttcggc gaacatgact tttttctctt 1856821 taaacgcccg ctccagctga aaagccataa atacttgctc gtcccgaaga tcaaaccctt 1856881 tttcgggaag gatatcgtaa aacacgtcac caatccaatt gttcaattct tcataaaaat 1856941 tctttgtttt cgttaaagaa aaaggcaaac gtgatgttgt cacctagttc caacccccaa 1857001 ctattcgaca ttcagaccac caataatatc attttccgct gatgaataca ataaaaaact 1857061 tggcaatgcc aagttttttg cagtttactt acgattgatc acatgcgacg ataaaaaagg 1857121 atggtctgtt gaataaatat gttctaccgc tttttctaaa tcagtttgcg catgcgaaat 1857181 cacagacgga gacgaatcag tcccgagctc cttcagctcg tttgctgttg cgtcaagcgc 1857241 cctttgaata agattaaaat gttcgctgtt cagcatgaga tcacctctga tggaaataat 1857301 catcattgta tgcgaacttt tcattttata tacatgcttt accgcatgtt atcaccgaaa 1857361 catgcacaaa ctacacttga tattccgtct ccggattatc cgtcttatca acaatattct 1857421 atcagggagt gatgttgaca tgagttatag aaaccgatta gatcagcatt ctgaactgtt 1857481 tcatcacaat tggacgcggc ctaaacgttc aaagtctcaa gtaaacggtc acactgaaat 1857541 gtcccaaacc aacattatat tgagaagcaa cgcgaaagct caccgttggt aacgatagaa 1857601 tagggctgaa agatgaaaga agacgcatgc agagcgtctt ctttttatgc gttttctgtt 1857661 ttcttgcgct gcggtcttac ttttgaccag tattgataat aatccgtttt aataaacccg 1857721 ttaaagagtt ttcgtttctt cgttgctttt ctgccatatg cttcctcaaa gttttcattt 1857781 gatgtcagca tatacacaga ccaagtatca agcggctcga acgcctgccc catttctttg 1857841 tacatctgct caacggcttt tttctcgccg agacgctctc catatggcgg gttgccgaca 1857901 attacgccaa attccagatt tgtggtaaag tctttgacct gcatctgttt gaactggatt 1857961 agatctccca atcctgcttc ctctgcattt tcttttgcga tttgaaccat gcggtggtct 1858021 atgtcgctag cgaaaattgt aagcggctga tcataatttg ccttttcttc gacttcaagc 1858081 cgcgctttgt tccacagatc tttaccgatc cattcccaat cctctgatac aaaatcgcgg 1858141 ttgaatcccg gggcgatgtt ttggccgatt agcgccgctt ctatcgcgat tgttccggag 1858201 ccgcagaaag gatcaacaaa cgggcggtca ggcgtccaat tggttaattg caccaaagcg 1858261 gcagcaagtg tttctttaat cggcgcaccg ccctgatcga cacggtatcc tcgtttgtga 1858321 aggcccgtcc ctgatgagtc cagtgtaatc aaagcctgat ctttcaataa agatatttcc 1858381 actttatact cagcacctgt ttcttcaatc caatcattgg ctttgccgga ctgcagcttg 1858441 agcttttcga caattgcttt tttgacgatc cgctgacagt caggaacgct tgcaagtgtt 1858501 gattttaccg attttccgat gacagggaat ttcccgtttt caggtataaa tgagcgccag 1858561 ttaatcgctt tcgttttttc aaacagttca tcaaatgttt tcgctttaaa agaagcaacc 1858621 tgaaccttta tgcggtcggc tgttctaagc caaaggttcg cacggcagat ggcaagtgca 1858681 tcaccttcaa aaataacttt cccgttatca accttgcatt cgtatcctaa atctcgtact 1858741 tcctttgcga caacagcttc aatgcccatc ggcgccgttg caattagtgt atacttcttc 1858801 atcgtatcac cctgtctttt aaaacttttc tcttttcaag ataaaagctc tccttatacg 1858861 ggagagcttg ttttcatcat tttaaatgta agtggtctaa cgttctgtaa gccatgtttt 1858921 gttccatcgt actgcaaacg gctcatcacc tcgtactcag gcggcaatca tctatctaca 1858981 gaaagcattc tgtccttctc tccgttgaat tccgttaaga aggttcccct accaaaattt 1859041 gggtttctcg ctcgaggggt ttaccgcgtt ccactctcac catttctagt gagacttcgt 1859101 cactgtggca ctttcaagga tactcagcca tatccgaaga cgtaggcttt tttcctgccg 1859161 tcagcctcta aagactgccc tagcttatga cttcgctagg cacgaacact acgggcatct 1859221 cagcaccgtg cgagcatgga ctttcctcta cagattcaag atctgcagcg attacccgaa 1859281 cgttaagaac atgaattatt atataacaac tgattacaat ttacaagcgc catttttttc 1859341 aagcgtgatc aatcataaag cttgctgcca aaaacgtgtt tttctaagtt agacagccgt 1859401 tttaaaatat caaagtttgt tgtgttagat tgcacaggct gttttttgct ggcttcttca 1859461 agctgttttt tcagctgcag attttcctgc tgcagttctt caatttcttg atggaaggtt 1859521 tcataatcct taataatcat atctaaaaat ttgtcaacgt cttcttgctt gtagcctcta 1859581 acgcctgttt taaattcttt ttccaaaatt tctttcgcag aaagctttac tttatcagca 1859641 agcatctttt tcacctcgta tcgtgaatca tcacatatat tttttcagaa atctgtacgg 1859701 ttgtcaaatt tctctctcat tgttagtagc tgtcttcctc cactgtcact ctcaagtcat 1859761 ccattgtaat aaagtagatg ggatagccat cctgttcgcg ccttttttcc gctgtcccaa 1859821 gcatatactt aggggagcct tccttttccg ggtcatataa aagcagaagc ccgtcggact 1859881 tatcaatgaa gaactgattt ttttgtttga attgaagcgg gctttcataa ggacggtgag 1859941 tcaggcttgc ttcatagtct gcctgagcca gaactgcttc atactgttct ttattcggtt 1860001 ctttccagtt cttttcctgc tcgtaaaatg gtgtgatgac agctaccttt aagtcagggt 1860061 attcctcctg caaatcatat gcagcttctg ccgcccacag ctcaactcca agctggcccg 1860121 aaattaaaat ccattctaat ccttcatcca aaaaagcaat cagccggttt ttaatggctt 1860181 tttttatgta atacagcgcc ttgtcatcct gcttaaatat ccccagttca aacggtttat 1860241 agcccgttat tgccaatact ttcatcattt cacctgcttt aaaaaatggg gctcccgtgg 1860301 gccccatttg ttgtgctgca ttgtttacac catcaagctg cacgttttcc atactagtag 1860361 tcgcagcaag gttttcctgc ttgaaaatgc tgatgcgtag ccgggtcaac atttgagaaa 1860421 gtgtgtggaa agtagtgaac gtgctgaaaa tgctggtggt ttacgtttgt tgtatgctgt 1860481 gggtgaatgt gcggcacgat agtcttcgaa aacgtatggt gttcacagca atgagtagga 1860541 tggacaattg gcgccatcat atgcggtctg cagtgatgca tgataaaatc ccctttccat 1860601 aaactttatt acaatactaa gttatgaaaa ataaggggta catgttctga tgcaaagacc 1860661 tattttaaaa gtgtgcaatt aagctgtctt taaagtttga aaacacaaaa gcaatcaaaa 1860721 ataccacaac aaagaacaag taaaaaacac ccttatacat accaactctc cctttaaaaa 1860781 taactaacgt cattttacag gattcgccgc tattctacaa caaaatcaat gtgaattcag 1860841 caaaaaaaat tcatggcgaa acaagtcgtc ttttgcgctt tcccggggaa tatttaagag 1860901 gaatatttcc tctttagccg ggcaattctc acatgcagtt tttcagtttc tttctctgat 1860961 aagcatgccg catcgctaag cgattgctct gctacttgca atgcttttcc gaattctttt 1861021 ttcttatgct caaaatattt cgcgagctct attacagcag cgtatctgca cttctggttt 1861081 tgcgagcggg acagcttttc ccaaagcggc actgcttctt ccaagcggtt ttgttttttg 1861141 tacaggagcg ataaatccag ccgtgcactg tcctggtcct caaacgattt ttctataagc 1861201 ctttccaact gcttgatcgc ttggtccgtt tctttatgag ccataaacca tttcgccata 1861261 gcataggctt cactgtgttc ttttggcgca tgtgattctg aaaggatttt tttagacata 1861321 tggatgtaca atgaaatgag tgataacaca tccatttcat tatgatgcag gacacctttt 1861381 aaaagatccg gctcttgcgc cttgataaaa tgaaagtaaa gcattggcgc caagtagccc 1861441 ggtgtgtctt ctagcctgcg gatgccgagc tcctcttttt caaccgtgcc aagagataca 1861501 cggtccattt tgtgtttcca caggcgtcta gctccatgca aaagatcaaa gtggccaaac 1861561 tccggaagct tcggaagtct gtcacggatc aaggtgtgcc ttgttttcac ctgcggccaa 1861621 tcaaaggctt tgccgttgta ggtcacaagt gatgtaatgt caacctcgct taaaaagctt 1861681 tggtacaagg cgacttcgtt ccccggtttg ggcaaaagat gctgtttgac tgtcactcgg 1861741 tcttcatata ctctcgcatg cccaagcaaa aaaatggtat tcccagctcc acccccaaga 1861801 ccggttgttt ctgtatcaaa gaaaaagagg ttgtttttgt tatacccttt tgctgacaat 1861861 gtatgcgaca ggccgctttg attccacagt gtgatcactt cctcaagctc agaaaagctg 1861921 tataacccat ggcggtgaga aagcggatat tctacttctc tgatgaggca atattcatct 1861981 tcgaagatga aaggcttcat gccaaaagcc tcccactctt ctaaaaacgg gatgtcatca 1862041 aagtggtttt cttgtttgcc tgcttctatt ttttgttctc cttcgtcgag cgccatgtgc 1862101 tttttcatcc gttggagttt cccttttaat gacatatccg gcctccctcc ttacgacatt 1862161 tgatccaaca gctgcaaaat tctttccttt gcttttatcc cttctatttc cgtacctata 1862221 caagacggac agccgtcatg acaaggacaa tgtgtaatca gttgtttcgc cgcttcatta 1862281 atgtctgaaa aacgtttaaa gacttcctcc gccaaaccga taccgcccgg ataatgatca 1862341 tataaaaata tggttggcaa tccggtatgg gctgctttaa tttgagaaac aacatgaaca 1862401 tcatttcgat cacacatgat atacacaggg acaatatgct gcagcacatt cgagatgcca 1862461 agaagcagct gttccagtgt cttttccccg atgtcttcat ccgctgtttt gatttcgagc 1862521 caagctgcac ttgtatgcag ttcttcttcc ggcaaatgaa taggtccaga cccaatattt 1862581 tcaaaagtgg tcatttttat ttttttaaaa atggtcggca gggcattgac agtgacgtct 1862641 ccgtagtgca atgacgtacg gcttttttct ttcgttttat cgatttctaa taccttcagc 1862701 tgaactgcca ggtttgcatc cgtataatat tcgacatcga cttttctgac atacgccttt 1862761 ttatggtccc aatcgagctt ctcaacttga tactgaacgc cttcatgcaa ataaatcgct 1862821 tcatcatgca aaagcgtcat cgcactaaaa cggtccattt caccgataat ccttacattt 1862881 gcaatatccg actgatcaac tataacgaca ttttcctggg aggcggaacg caaactgatg 1862941 tttgacgcag ggaacgactc acttgcccaa tggtaccgtt cgccgttgcg gtgaagaaca 1863001 gcctcttcct gaagatactc aagaatatca ctgacttcca tggctccaaa ttcttcatca 1863061 gctctaaaag gaagctcata agccgcacac tttaagtggt ctactaaaat aatcaaattc 1863121 tccggattga ttcttgcaga ttccggcgaa cgattaaaga aatattcagg atgccgcaca 1863181 atatattggt caatcggtgt tgaattggct accatgataa tcaaagattc accgtgtctt 1863241 ctgccggctc gtcccgcctg ctgccaagca cttgcaacac ttccgggata ccccgtcatt 1863301 acacacactt gcagctggcc gatatcaaca ccaagctcta aggcattcgt actgaccact 1863361 cctaaaatgt cgccttctct cagtcctctt tcgatttctc ttcgctcttt cggcagatag 1863421 cctccccgat agcctctgat tgattttgtt ccaatctctt ttttcacaag ctcctgaata 1863481 tggcttaaaa taatttccac ccgaactctg cttctggcaa aaacaatggt ctgcactttg 1863541 tttttaagga actctttcgc cagttcattc acttctgcgg ttgcgctcct tctaatattc 1863601 agcggtttgt tcacaattgg cggattgtaa aacacaaaat gcttgcgtcc gctcggtgcg 1863661 ccgttgtcat cgaccagccg catcggtttg cctgtcagct gctctcccaa ttcctttggg 1863721 ttggcaatcg ttgcggaagt acaaataaaa actggatcac ttccataaaa ccggcagatc 1863781 cgcttcagcc gccggatcac atttgccaca tggctgccga acacacctcg atacgtatga 1863841 agctcatcga tgacgatata cttaaggttt tcaaacaaac tgacccattt cgtatgatgc 1863901 ggtagaatgg cagaatgcag catatcgggg tttgtaatga caatatgacc tgcttttctc 1863961 accttttgtc tgattgccgg agacgtatcc ccgtcatatg taaagctttt aatatcaatg 1864021 cccatttcat caataatttc atttagctcg ctcttttggt cttgtgccag cgctttagtc 1864081 ggaaataaat ataacgcccg gtttgtttca tcttgggcga tggactgcag gactgggagg 1864141 ttgtagcata acgtttttcc tgatgctgtt ggcgttacgg taacgatgct ctctcctttt 1864201 tgcacatatt gaaaagcgga atattggtga gtatatagtt catcaatgcc ccttttcgaa 1864261 agggccgctt tgattctctc gtctatactt tcgggcatag gccttgtttt tgcttcccga 1864321 ggctcaattt catgccaatt cacaacgttt tcatttcctt ttaaatcaga aatgagttca 1864381 gtcagtgatt tctttttcat tctttacacc tctttgtcaa gtacagttta ccgaatattt 1864441 gtttgcatgg ctaggtgcaa attttataca gttgaataaa aaaagcaagg catacgccct 1864501 gcttatttcg cttttattgt aaagagcttt gattcgcctt tacgagcagc cttttcgcct 1864561 gccgatacca ttgatcctac agcctcacca ttcattataa cgattgggat gactgtgctg 1864621 ctcgcttttt cttttattaa ttccaaatca catgtaatca gcgggtcacc gaccttcact 1864681 ttatcccctt ctttaatgtg ggcagtaaat ccttctccgt tcatattgac tgtctccagc 1864741 ccgacatgaa ttaacagctc aattcccgag cgagtccgaa tgccaacggc gtgtttggtg 1864801 tggaaaatct gaatgacttc accttcagcg ggagaaacga tttcaccgct agaaggttcc 1864861 accgctattc cttctcccat cattttctgt gaaaaaacag ggtccggtac atctgacagg 1864921 tccattactg taccgtctgc cggagaataa ataacctctt ctgtcacctt ttcctgaatt 1864981 ttgcccattc cgaataattt tttcagcaat gtattttctc ccttctcatt cacttcaacc 1865041 gttatccctt cattcaccac tatttaacca cactttcaat tttgcttcaa tttataacaa 1865101 catctggcat agacgcataa tctggttaaa aaaggcggtg gcgatattgg aattccatga 1865161 tgacaaaaag aacgaactgc aaaagaaaga agaaatcata acggaggcaa tcgacactct 1865221 ttttcaatcc tcagcgttcg gcaaccttat aaacggattt cagaacctaa tcaactcgag 1865281 tttaaaggat gtgcagacga ccatacatgt cagagaaaga gatactgggc tgtatatcga 1865341 tattaccatt ccggcgacgt ttcgagatgg cgagatcgtc gttgatgtta aatcgaggta 1865401 tctccatgta acactccaag aaaaacagaa acaccaaaat gaggctacct ttacaagcat 1865461 gacaagaacg gttcagctgc cttatgaagt tcgccaagaa gatatggaaa cgtcttggaa 1865521 cgagcagaca atgacacttt tctttccaaa aaataagcat gaatgaacga ttcattcatg 1865581 cttctatcat ttaaaaaagc tggtaaatcc ctttattaaa gatccgacct gattcattgc 1865641 actcattact tgacctgtcg tatccatcat tttattaaaa tcaaattgcc cattggcttt 1865701 tttgaactgc gacataatgc tttgaaattg tgaaggctgc tgttgattag gccttgggat 1865761 aggataaggg ttagaaaata caggcggctg cataggcata ggctggatcg gagcataagg 1865821 ctgataataa tcctgctgtc cataatgctg ctgaggcagt tgttgctcta aataaccggg 1865881 tgcagcctgc tgataatatc cttgcatatg ctgaggataa taatagccca tttgccgagg 1865941 atagcttcga gagctcccgt tcattgcgat tcccccctaa acacaacata tttctcttct 1866001 atatatgtat gaatgacttc tattgtttgt gtcacaagtg atgattagca tttgtcaaat 1866061 tgtgtcgaaa gtttaaattt tttaaaaaca gaaaaaagtc gaatcattat ggtaccatat 1866121 tttcaataca gatgagaggg gatgcaccat aatgaacgta tcatacttaa gcaaacgttt 1866181 tgcagaaatg aagaaatatg aaacagactg tatgaataaa ctgatggact ttgccaagtt 1866241 cctctatatt caaggacatc tcagcataac tgagtttcgt aacagtatga aggttctcga 1866301 agcaaatgga gcagaaagcc cggcatatga gatgaattaa cgtccggccc cctataaaaa 1866361 cgaaaagaag acagcctttt accggctgtc ttctcttgca atttcatcct ttactgcgtg 1866421 caatgtataa aggactgact cagtgatgtc cttgaatcgt tttttatgaa tatgatgaac 1866481 ataagattga aggaccaatt ccaggaaatt atcctttacg gcctcaattt gctctttatg 1866541 cacatatttt ggccggcgga cttttatcaa ttcaagagca ccctctgccc agcgagcagc 1866601 cagttcatca ttctcttcaa ctgcaggctt tatcgtctca aaaaaatcat aagaatgatt 1866661 actgtttttt ccttcctgat accgatcagc gcctttttca gcaacttcaa tcatttgctc 1866721 ggtcatttcc agcaaagttt gtgatagcaa tatctttcac ctcaatgcct atcgtaccaa 1866781 atttcactca caaattcagc cgatgcggta taccttctca aacgcatacc tgtgttcagg 1866841 cgattgatac agctcattta tacaaatatg aagatctatg atttcttctt cgagcacact 1866901 taggcgatcg ttctccgttt cccgcatctc agcctctaat gcatttacag aatgattcag 1866961 gctttgctca gctcgcgtta attcatcttc tatatcagaa agcatacgga gaatatctgt 1867021 cttgcataca taaccggaca ttcgtgtacc tccctttcct tgtctctccc ggttaacatt 1867081 ctttgctctc aaggctcttt ccttcctcat gacaaaacta gaagcaaatc gccaaacaaa 1867141 caggtattcc acgaaaagct gaagttttcg acaaaaacac ccgcaaaaat tgtatgatcc 1867201 tcctcattaa tgcaaacgat acttgtgagg aggtgccgta tgaaaacaag accgaaaaaa 1867261 gccggccagc aaaaaaagac tgaatcaaag gcaatcgatt ctttagataa aaaattaggc 1867321 ggcccgaacc gcccttctac gtaagaagca aggaatttcc ttgcttcttt attttttcag 1867381 ccactgctcc accgcaaaaa gcgcatgaag ctggcgcttt ttatgtaaat accagtctgt 1867441 caattcaatc tgcttcggca attcctcgcg cctaaagaac gttttcttta tctttccatg 1867501 aaaccaatct gttttcgttc cgtctaatga gtggattaac tcagggtagc atgtccttag 1867561 cataggagat gttctttttg taatcccgat catcttttcc atatcaaaac gggaacctgt 1867621 gtgcggcact gtgtgcaaaa agtgataaaa agaggagaac aattctggct tgaacagcaa 1867681 ttgagacagc tgctttccca gccttatcct ttcctccgcc tttgaaaagc gtttcactga 1867741 aatgccgtaa aaaaacccat ttgaggaagg aaaaataacg gtgttaaaat gaaaccagtc 1867801 acttaaataa aaaggaatcg tgtcaaaaac attcttttta aacgaaggat tttgtataat 1867861 aggtgtttgg atagtgtttt gttcatttat aatgagggca tacattagcc gctccgtatt 1867921 tcgctcatgc caaaaacggg tccattcttc cgacataaat tgtgagacgc caaacacatg 1867981 cagcagatga aacagcggtt tcccaactct ttttgaccag tggtataaaa gaagctgcgg 1868041 ataggcatcc gaaaaaataa gccagttcgc tctttcatag gctaaaaaga accatttttg 1868101 ctgtctctca cggagtccaa gctgaaacag actgcctttt aagtcagtca ttgaccagcc 1868161 ggcattacga gaaacgaaag aagccaaaag cgaccatttg atttccggat gacggtcgta 1868221 aaatgcttta taagcatttg ttcttgaaat gttatccgcg tttttcattt ttgtctgccg 1868281 ctcaatccgg ctcagaagct ttctgatggc ctgttgttct tgcacgttca ttcacttccg 1868341 tcatgattag tttaataagg aggatgagaa agtgattcgg tatcctaatg gaaaaacatt 1868401 tcagccgaaa cattcggttt catcccaaaa cagtcagaaa agggccccgt cttacagtaa 1868461 tcgcggaatg accctcgaag atgacttaaa cgaaacgaat aagtattatc tgacaaacca 1868521 aattgccgtt atacacaaaa agccgacacc tgttcaaatt gtaaatgtcc attatccaaa 1868581 aagaagtgcc gcagtgatta aagaagctta ctttaaacaa tcatcgacaa cagactacaa 1868641 tgggatttac aaagggcggt atattgattt tgaggcgaaa gaaacgaaaa acaagacctc 1868701 tttccccctg cagaattttc atgaccatca aatcgagcat atgaagcagg taaaggctca 1868761 agacggtatt tgttttgtta ttatatccgc tttcgaccag gtttattttt tggaagccga 1868821 taagctgttt tatttctggg acagaaaaga aaaaaacggc agaaaatcaa ttcgaaaaga 1868881 tgagttggaa gaaacagctt atccgatttc tcttggatac gcacccagaa ttgattatat 1868941 tagtattatt gaacagcttt atttttcgcc atcatctggt gcgaaaggtt gattaacgaa 1869001 aggttgagat gttatgtcag atcaatttaa cagccgtgaa gctcgacgaa aagcgaacag 1869061 caaatcgagt ccttcaccga aaaaaggcaa gaaacgaaaa aagggcggat tgtttaaaaa 1869121 gacccttttc actttactca ttctgtttgt tttaggcgta gtcggcggtg ctgttacatt 1869181 tgccgtcatg gtttctgatg cgccgtccct tgatgaaagc aaattgaaga cgccttattc 1869241 atcaacgatt tatgataaaa atggaaaaga gatcgccgaa gtcggcgccg aaaaacggac 1869301 ctacgtctcg atagatgaaa ttcccgatgt tgtaaaagaa gcctttatcg cgacagaaga 1869361 cgctcgtttt tatgagcacc acgggattga ccctgtccgt atcggcggtg cattagttgc 1869421 caactttaaa gacggcttcg gggctgaagg cggaagtacg atcacccagc aggtcgtcaa 1869481 aaactccctt ctttcacatc agaagacgtt gaaacggaag gtgcaggaag tatggctttc 1869541 gattcagctg gagcgcaatt actctaaaga tgaaatttta gaaatgtatt taaaccggat 1869601 ttatttttct cctagagcat acggaatcgg aaaagcggcg gaagaatttt tcggcgttac 1869661 tgatttaagc aaattgactg tcgaacaggc tgcgacgctt gcaggaatgc cgcagagccc 1869721 aacagcgtac aacccggtca aaaacccgga taaagcggaa aaacgacgga acatcgtact 1869781 cagtctgatg aaaaagcaag gatttatttc tgattctcaa tataacaaag cgaaaaaagt 1869841 ggcagtgaaa gacgaaggcg tcgtgtcaca gaaggaatat gaaaaagcaa gtacaaacaa 1869901 atacagcgca tttgttgaag aggttatgaa ggaaattgat gaaaaatctg atgtcgatcc 1869961 atctgctgac ggattaaaga tctatacgac attagataca aaagcacaag ataaactaga 1870021 tgaattaatg gacggagaca ccgtcggatt tactgaaggc atgcagggcg gtgtgacgct 1870081 tctcgatacc aaaaacggag aagtccgagc gattggtgcg ggacgcaatc agcctgtcgg 1870141 aggctttaac tatgctactc aaactaaggc acagcctggt tcgaccataa aaccgatttt 1870201 ggactacgga ccagttattg aaaataagaa atggtccaca tacgaacaaa ttgatgactc 1870261 agcttatacg tattctaacg gaaaaccgat tcgtgattgg gaccgcaaat atctagggcc 1870321 tatctcaatg cgttacgctc tggcccaatc aagaaatata cctgctttaa aagcattcca 1870381 ggcagtcggt aaagatactg ctgtagactt tgcaaatgga ctcgggcttg gtttaacaaa 1870441 agataatgta acagaggcct attctattgg cggtttcggt gggaacgatg gtgtttctcc 1870501 tctgacaatg gcaggtgcat acagcgcgtt tggaaataac ggaacgtata atgaaccgca 1870561 ttttgtaaaa tctatcgaat ttaacgatgg cacgaagctt gacttaacac caaaatcaaa 1870621 atcagccatg agtgattata ctgcgtttat gattacagat atgctgaaaa cagctgtgaa 1870681 gacaggtact ggacagcttg cacaagtacc tggtgtagaa gttgcaggaa aaacaggaac 1870741 gactaacttt gatgataatg aagtcaaaag gtacaatatc gctagcggtg gcgcccgaga 1870801 ttcttggttc gttggctaca caccgcaata tacagctgcc gtctggacgg gaatgggaga 1870861 aaacgaggct ggaaagaaat cactttcagc tgaagagcaa aaagttgcaa agcgcatctt 1870921 cgcccagctc atcgccgatg tcgatgacgg aagcggatca tttgagaagc ctgacagcgt 1870981 agtggaagcc accgtagaaa aaggttctaa tccggcaaaa ctggcagggc caaatacgcc 1871041 aagcgataag aagctcacag agtactttgt taaaggcaca gctccttcta ctgtttctaa 1871101 aacatatgag aaagaagaaa aagaggaaac agctaaactg tctggtttaa acgtgaaata 1871161 cgataaagac aatcaatctt taacgttaag ctggaattac gacggagatg cgacctttgc 1871221 tgttaagcaa tctgttgacg gcggcagcta ctcggaaatt caaaacagct ctgcaaaaga 1871281 ggcagttatt tcgggtgtgc agccaggatc tgtatacaaa ttcgaagtaa cagccgtcag 1871341 tgatgatggc aaaagtacag cttccacatc ttatgaggtg ccaaaagctg aagacgatga 1871401 agataaaaaa gaccagcaac aaacggatga tgaaaaacaa gatgatgaga agactcagga 1871461 tgatacacaa actgatgatt ctcaaaaaga tgacggtcag acggatcaag atcagacaga 1871521 tgattcaaca aacgatcaag acaaaaaaca agacaatacg aacaccaatc cgtccgacaa 1871581 caataaccaa gaccaatcaa acgataatga taacgacaac agtaacaacc aggatacgtc 1871641 ggatggtgat tcgaactctg gtaagaatga ttcaacaggt tctgacacga ataaaaataa 1871701 aacagacaca tctaataaaa cacaaacaaa ctcatcatcc attgaaaaaa caaattaaac 1871761 aaaaaagccg tcacctttgg ggtgatggct tttttggtac acaataaaaa acctcccgtt 1871821 ttaacaggag gttttatcga ttcatcgcat gatatttata aaaatgcttt ttcatttcgg 1871881 taatcagctc atcaagctga ataaagcaat ggtattgggt cggcttaaga agaataaatt 1871941 ccactcgttc agcccaatta atcggctttg cgggatatga tttctccctc agttcttgcc 1872001 aatcgagcga tttcaccggc tcacctgctg tccaatgtaa cgaagccagc aaacacacaa 1872061 tgccctttaa catttcgttt tggtcacatc tcgattttcg tgtttgaaag actgggagaa 1872121 gtgatgcttt gatgtcatcc cacacttcaa ataaaagcgg aacgtatttc ccgctgtcct 1872181 cccatggcaa atcgccttgt aattccgtgc agaaatcaaa atacacggga ttggtctgca 1872241 aggttttctt catatccgag gaactcttct ggccaagact gcgcaagtat tgctcatagg 1872301 aagccaacac ttcttttgct tgcgtcatcg tttcaccagt ccttttttat ccctcttctg 1872361 cccttctctg cacaaagaaa gcagcggaca ctccgcacag cgcggagatt gggctttaca 1872421 gtgatatctg ccgaagaaaa taagccggtg atgcgtaacg gaccaatctt ctttgggaac 1872481 cttgcgcatc agcgtctttt caacttccag aaccgagtcc ttccaccggc aaatgcccaa 1872541 tcgtttgctg actctctcca catgggtatc tacggctatg gccggcacgc caaacgcaac 1872601 ggataccact acgtttgcgg tctttctccc gacccctggc agtttgacaa gctcatcgcg 1872661 gtctctcggc acttctccgc cgtaatcttc aataatcatt ttactcagct tttgaatatt 1872721 tttcgcttta ttacgatata aaccgattga tttaatatcc tgctgaagct cttccagcgg 1872781 aacagccaaa tagtcttccg gccgtttata tttttggaat aatgttttgg tcactctgtt 1872841 tacaagtgca tctgtacatt gcgcagataa agcaacagcc accactaatt caaaaggatt 1872901 ggaatgaacc agttcacact ccgcatgagg aaacatgtca cctatcttgt ctaaacagaa 1872961 ttcaatttgt tttagattta acacgattgt caccttttca ctttattgtt caagccaatt 1873021 gtaaaaagga acctgccttt tatactcttt ttgcggttca ttctgctttg cttgtacacg 1873081 ccggaatttt tggctgtgta tttttgcctg ctccacagtt ttaagcccat ttttcttcca 1873141 ttcaaacaaa atccggtcaa tgtagcggaa actgagtttt cctgatagta cagcctcttt 1873201 taacgcgtgt ttgatcagtt gtgcgtcatg ctgatcctgg tcctgccaga tcgccagcgt 1873261 ttcacactcc aaaggcgata acggtcttgc gaactcttcc tcaaaaatgg tataaaggct 1873321 tttttgttcc ccttctgctt ttctttcctg tgtttgattc tgtgcaagct gaatatactc 1873381 gtacagcttg ccccataaag gctgaagaga atatttctca aatttgatgc cgttttgatc 1873441 ctcgcattct tcaataaaca gaaagccttt ttgaataaac atccgcaatc tgtttgtaca 1873501 ttcttcaaca gaaattgaca taccttcctg cagctgattc ggtgtaggaa aatatgatcc 1873561 tttttctaaa tgcattttaa tttttaacag cagaataagt tctgtttcat taagcccaag 1873621 ctgtttataa tgcgtgagca gaagattggg gatggttgat gttccctgct cctgcatatc 1873681 aataaattgc tgttttttca tcgtcacacc tcttactgta aaggattgtg attgcccctt 1873741 tactgtaaaa agtctccctt gcaggagact cttttttgtt tcatttgaat gtattacgga 1873801 tacagacggt ttaacagtct tgggaacgga atcgtttcac gaacgtgagg cgctccgctg 1873861 atccaagcta ctgtccgctc taatccaagg ccgaagccgg aatgaggaac tgatccatat 1873921 tttctaagtt cagcatacca tttataagcg tcagaatcca gtccatgttc tttaagacgc 1873981 gattccaaaa gttccatatc gtgaatccgt tcagacccgc cgatgatttc tccatagcct 1874041 tccggcgcaa tcaagtcagc gcaaagcaca acgtcctcac ggtcagaagc cggctgcata 1874101 tagaacggtt ttaaggacgt cggatagcga gtgatgaata ccggtttgtc ataatgttca 1874161 gcaatcgctg tttcatgagg cgctccgaaa tcatctcccc actcgatatc gtcaaagcct 1874221 ttttctttca gaaattcaat cgcttcatca tacgtaattc ttgggaacgg ggctttgatt 1874281 tgctcaagtt ttgacgtgtc tcttcccaat gtgtttagtt caattttgca atttttaaga 1874341 actgattgca cgatgaaaga aacgtaattt tcctgtactt gaaggttttc ttcaaattct 1874401 acaaacgcca tttccggttc gatcatccag aattcgatta agtgacgctt tgttttagac 1874461 ttttccgctc tgaatgtcgg tccgaaagag aatacttttc ctaaagccat tgccgcagct 1874521 tccatgtaga gctgtccgct ttgagacaga tatgcatctt catcaaagta ctttgtcgca 1874581 aagagttctg ttgttccttc aggtgcgctt ccagtcaaaa tcggcggatc cacttttacg 1874641 aagccttcgt tattaaagaa ttcgtaagtc gcgcgaatga tttcattacg gattttcatg 1874701 atcgcatgct ggcgctttga acgcagccat aaatgtctgt gatccatcaa aaattccgtt 1874761 ccgtgttctt ttggtgtaat tggataatcg gtcgcttcgt gaatgacttc aatatctgtc 1874821 acagcaagtt catatccaag cggagaacgc tcgtcctctt tgacaatccc ttttatatag 1874881 agcgacgttt cctgcgtcac tgatttagct gtttggaaaa tgctttcttc cacttccgct 1874941 tttactacga caccctgaat aaaaccggta ccgtcccgaa gctgtaaaaa cgcaattttc 1875001 ccgcttgaac gcttattagc gacccaagct ccgatcgtta cttcctcacc tacgtgcttg 1875061 tacacttggt tgattgttgt tttcaacata tttccctcca aaacaagaaa gacattcgga 1875121 agctcattgc cccgcgaact cttttatcat cactttatta tacccgctct taactaaccg 1875181 ggtcaatgca gataaaaagc ggcttttctg tcagccgctt tttgatctgt tagctatgtt 1875241 tttctacaaa acgcttgatt ctttcaatgg cttcttcaag aagatctaac gatgttgcat 1875301 aagaaagacg gacattctca ggagagccaa atccggatcc tggaacaatc gcaacttttt 1875361 cctcctcgag aagcgcttta acaaattcat ctacatcttt gaaaccgcaa gattgagctg 1875421 cctcttttgc atttgggaac aagtaaaaag caccttccgg cttcacgcag ctgaaccctg 1875481 ggatttctat gagctttgca tagatcgtat ttaatctatg ttcaaatgct tctctcattt 1875541 cttccaatgg ctcagaaggc ccgttataag cagcaatcgc tccgtattgt gcgattgatg 1875601 tcgggtttga cgtgctgtgg cttgcaaggt tcgtcatcgc tttaataatg tcttcagagc 1875661 ctgccgcata accgattctc cagcctgtca tgctgtggga cttcgatacg ccgtttataa 1875721 tgaccgtttg ctctttcagt ctgtctgaca gctgtgcaat ggaaacatgt ttctttccgc 1875781 cgtatgtaag tttttcataa atttcatctg acacaatcaa gatatcatgt tcaaggcaca 1875841 cttcaccgag cgcagatagt tcttcttccg tatacatgac accagtcggg ttgcttggag 1875901 agttaataac gattgctttt gttttttccg taattgcatt tttcagctgc tcaggcgaaa 1875961 ttttgaagtg attttcctca agcccttcta cataaacagg ctttccgcca gcgagtttca 1876021 cctgctccgg gtagcttacc cagtaaggcg ttggaataat aacttcatct tcttcatcca 1876081 aaatcacttg gaaaagggta tacagagcat gtttggcacc agtgcagaca ataatttgag 1876141 acggtttgta ttcaatattc tggtcgcgtt taaatttctc tgcaatgctg tttttcagtt 1876201 cagccaaacc accggaaggc gtgtatttcg tatggccctc gttcatcgaa cgcacagcgg 1876261 catcaataat atgctgcggt gtattgaagt caggctcgcc tgctcctaag ccgatgacat 1876321 catggcctgc ggctttcagt tctttcgctt tcgctgtgat tgccagtgtg gttgatggtg 1876381 ttaatgcgga tactcttttt gccagtttca acttgaactc cccctaattc gtcttaaggc 1876441 gtgatatttt tgagaatctt tccagttgta aagtccacat aacttaaact gtattgccct 1876501 tctttgtcta agtacgtcac ttcccaaagc aggacgtttc cttctcttgc cagatgaacc 1876561 tctttttgct ttgaaaccag cccttcatcc tttatgattt tcgccgcttt gtcttcagag 1876621 attccctctt tcgcttcttt tgagagaatt tttgcttttt tatcagcagg aacccagaca 1876681 tataatgcag tgcctttttt atccgttccc tttacaacat aatatttttc ttttccgaca 1876741 aatgtttcga cttgatcaac atgggcgaga tcggtttctt ttttagcttc agcagctgct 1876801 gcttcgtgcc cctcttcctt ttgtgccatg gctgatttat aaatgcttgc cgagacaaga 1876861 agtactgcta aaaaaataat accaaaaatg acggtaaata ttaatgcttt ttttctcatc 1876921 ttctcaccta cgtacgataa atggtaaaaa cggcttggtt tttgttttct tcatccagcg 1876981 caaggccgaa catcagattg tctcttttca gtgtacgatt caatgtgtcc acaattttat 1877041 acagatcatc agaatgctct acattaattg ttgaaagaat ttcgatttta ctttccattt 1877101 tttcatcctc cagtttgaac aaatattgtt agtcatactc catttcagga cacgccatac 1877161 tagtatcaca gagcgggaaa tccgctttta aataaaacac catcctactc ccacaccgca 1877221 aaagccgctt tatgcggctt ttattctttt tcccctgcaa cataagcttc aagctcgctg 1877281 tcagtcattt cggatactga ggttgtcggc aaggcatcaa gaaacagccg gccgtaacca 1877341 gcggttttaa tccgtctgtc caatataata atcgttccct tgtctcccgc agaacgcagc 1877401 aagcgtccga ttccttgcct gaaggtcagc acagcttccg gtaatgacac tgtttgaaac 1877461 ggattctttc cttttttgcg ggcaagctca cattttgcag catgaagcgg gtgatcaggg 1877521 gaccggaatg ggagcctcac gatcattact gtcgtcagct catcaccagg gaaatcaacg 1877581 ccttcccaaa aatgatttgt tccgagcagg atcgcctgat tggatgtttt aaaagtcttc 1877641 atcagtttgc cgggacttcc gcctgtaatc ccttgtgcca agagctgaat gccggaagca 1877701 ctcatgttat gcttaagctc ctggtgaacc tttttcagca tatcatggga tgtaaacagc 1877761 acaaggattt taggctgttt ttcctttgcc atcagttcga tataacgggc tgtatcctgt 1877821 ataaattcag gttgccctgt atcctgaatt gatttcattt cttttggaat catcacctgc 1877881 atacgctcat cgtaagaaaa gggtgactca attctcattg tccgcgggaa aaagtcactc 1877941 agtcccagtc gttcaatcat aaattgaaaa gaaccttcga ctgtaagagt tgcagatgtc 1878001 agcaccacac tatttttgcg cgcgaaaaac tgatcagcca gaagttcacc aggttcaaga 1878061 ggctgtgcgt aaatggccac tgcatttttc gcaccctttg catctatttc aatccaaacc 1878121 gcttcatcgt catcagagcc aaagaagagc ttctgcaacg tctgacagta atgctgcaag 1878181 cctttcatgc ttctttggta ttcatcggct aaaaagacgg ttttgctctt catgcccttc 1878241 aaatgttttt ccataaggga tgactgcgcc tcaaaaagct gctgcaaatg tgtcagcatg 1878301 gaacaaagcc tctccgcacc atctgttaag atcgaccagc ttttatcctg gctttctttg 1878361 ttcaccttaa acactagacg gtttaagtct tctttaggtt ttcttcgttt gacaaaagaa 1878421 tgtacagagc taaagaaagc atcactttct gcttgaacgt gctgaagcca ctcttccaat 1878481 tcgaaaaatg aatcaaccgg caggctgttt cgctggaata gctgtctcat cttttttaga 1878541 agtccctgct ccttcagagt gccgattctg ctcaatttcg tatgcaattc tatgtacgtg 1878601 gctcttttcc ctaaatgttc gcttgccgca cgttcaaaat ggtgtgcttc atcaataata 1878661 aatgtgccgc tttcgggaag ccttttttta tggctgcctt catcggtcag caaaagagaa 1878721 tgattggtga tcaccaaatc ggaacgcata gcaatctgtt tggcccgctc gtaaaaaccg 1878781 atcacatgct cactgcgact tcttttatag gagtcatcgt cataagccaa tctgtcccac 1878841 agcaattttc cgcctgaagg caaattcagt tccgctacat ctcctgtatt tgtctctgtc 1878901 agccaaacaa gaagctgtgc ctttgtcagt acggcatcat aattatcatc ttcttcatga 1878961 agcacctgct caaatttata caggcataaa taatgcgatt gcccttttaa aatcgccgct 1879021 gttaccggaa atggaaacag atcttggaca atcggcaaat cctttgtgag aatctgctgc 1879081 tgtaaaagcg tcgaatacgt gctgattatg accggctttt ttgatttctt ggcaaaaagc 1879141 gcagccggaa taagatagcc aatcgttttt ccgatgcctg gaggagcttc aatcagcgca 1879201 tgctcacgat tggcaaacgc atcagccacc tctctcatca tcatcatttg gccgtctctt 1879261 ttttcatacc caggcattaa ctctgacagc gctttttcat ttcccgcttc ccagctttcg 1879321 atctcaaatg agaagttctc gtcctcattt atacgaacat cgatagcttc aggttctctg 1879381 acagaaaacg aagaaaagcg cgtatagccc ggtatctcgg tatgtctgtt ttcattaatg 1879441 aacatatcca acaaatgcgt cagatcactg atgaaatgct gcgaaagcct tcttaactgc 1879501 tttaatgtcg gataaggaag ctgccgcagc ttttcaagga tttccaaaaa aataagccct 1879561 gtcacttcag catcgctgtc agcccggtgc ggctgatcat gccgcagctg aagctcctcg 1879621 cttaattccg tcagcttata cccttcaaat cccggaaaaa caatgcgtga gagctcgaca 1879681 gtatcaagca cttcacaatc tgggagctga aagcccgcct tatgtagctc atacttgaca 1879741 aatccaaggt caaaatggat attgtgggcg acaaaataag cgccgtcaag caattggaat 1879801 acttcttcag caactgcttc aaatggctgt tcattctcga ccatttgatt agagattcca 1879861 gtaagctgct caataaaagc agggattgat ttatttggat taatgtattt tgaaaaccgc 1879921 tcagtaattt gtccattttc gattacaacc gctgcgattt gtatgatttt atcgcctttc 1879981 ttcggcgaat tccctgttgt ctctacatct ataacaacga accgttgctt attcattaaa 1880041 atggacacct caattcttgc atacgacaaa agtgtaacac gttttgtacg gaaatggagc 1880101 ggcaaaaccg ttttactctc aaaatcttaa aagaaaaccc ccgataaagg gggcttttct 1880161 tctacaaaat tgtacgggct ggttcgttcc ccagcatttg ttcaattttg ttttgatcat 1880221 tcagaacagc cactttcggc tcatggcttg ccgcttcttg atcagacatc attttgtagg 1880281 aaataataat gaccttatct ccttcctgca caaggcgtgc ggctgcaccg tttaagcata 1880341 tgacgccgct tccccgttta ccaggaataa tatacgtttc aagacgtgct ccattattat 1880401 tattcacaat ttgtactttt tcattaggaa gcattcccac agcatcaatg agatcttcat 1880461 caattgtaat gcttcccaca tagttcaggt ttgcttccgt aacagttgcc ctgtgaagtt 1880521 tgccgctcat cattgttcga tacatattat attctctcca tttctcgaat atcaataatg 1880581 atattatcta ttaaacgcgc ttttgaaaaa gcaactgcaa cagcgagaat catctttcca 1880641 gcaatttcat tcacaggctc gagttccgga taggaataaa gctctacata gtctatggtt 1880701 ccgctagtcg tttcaatgat atcttttgca gcttttatca ccgcttcagg atctctttca 1880761 ccggcttgga caagttccgc acttgtttga agggcccgat acagcttagg cgcttctttt 1880821 ctttcctcag ctgttaagta tacattgcga gagcttttgg ctaagccgtc ttcctctctg 1880881 accgtatcga caggaaccaa ttcaatatcc atgaagaagt cgctgattaa cccatcaaca 1880941 acagctacct gctgcgcatc ttttaaaccg aaataggcac gagtcggctt gactagattg 1881001 aaaagcttcg tcagtacgat cgcgaccccg tcaaaatgtc cttctcttga gcgcccgcat 1881061 aacacgtctg tgcgtctttc tacatgaatc gtgacattct tttcaccggg atacatatca 1881121 tgagcatctg gcgtaaaaag aatatcgact ccggcgtttt ctgcaagagc tgcatcccgc 1881181 tcaatatcgc gcggatatgc ttcaaaatct tcattagggc cgaattgtgc aggattcaca 1881241 aaaatactca taataacggc gtcgttttct tgtcttgctt tgtctgctaa ggttaaatgc 1881301 ccctcatgca gaaaccccat cgtcggaaca aatccgattg acttgccctc tgaatggtat 1881361 tgttttatgg cttctttcag ctgtgaaata tcagtaatct gtctcatctt attttccccc 1881421 gtacaagccg tcaagcactg tctggttcat ttgaaaggaa tgcttttgtt cagggaaagc 1881481 acgatgtctt acatcctgaa catatccgct gattgctgtt tcgatggttt catcaatgcg 1881541 cgtatattgc tttacaaatt taggtgttct ctcaacaccg tggccgataa tatcatgata 1881601 aacgagaact tgtccgtccg ctttcacacc agccccgatt ccaatgaccg gtatgcttag 1881661 cgtctcggca attttggctg tgagttctgc cggcacacat tccagcacaa gcatcatagc 1881721 tcctgcttct tcgcatttta tactgtcttc tattaatttt ttggcgcttt gttcgtcttt 1881781 gccctgtact ttatagccgc ccagtacgcc gactgactgc ggtgtcaaac ctaagtgact 1881841 gactactgga atgcctccaa gcgtcaatgc gcgaatggat tcaaacacgc cttctccgcc 1881901 ctcaagcttc agtgcgtcag ctccgctttc ctgaacgata gccgctgcat ttttcagcgt 1881961 atcttcctta gacaggtgat aagacataaa cggcatatct gtcacaataa aggtattcgg 1882021 cgcacccctt ttaacggctt ttgtatgatg gatcatgtcc gcaactgtca caccgacagt 1882081 tgaatcaagg ccgaggacga ccattccaag tgaatcaccg actaaaatca tgtcaactcc 1882141 cgcttgttca gcaagtttag ctgccggata atcataagcg gtcagcatga caatcggttc 1882201 ttcagactcc ttcattttta gaaaatccag ttttgttttc atgttttctc ctcctcatgt 1882261 ttagaggaga tgatctgccg ttttcttctg caagccaaaa aaccttccgt tacaacgaga 1882321 aggattcttc actttctaaa gttcggcgag tttcatccct ctgtcccagt ccttttttgg 1882381 atcaaggcag actgctgcaa tgtctatcta ttttaataat aggtgcagtt cgcaggcgat 1882441 actgcccaat ggaagtatac caaaatcaac gggcttgtac caacacatta gcccaattcg 1882501 atatcggcag aatagatttt tttaatgcct tcgttcgttt ctaaaagcag aacgccttca 1882561 tcatctatac ctaacgcctt accgtaaaag gttccgttta acgttctggc tctcatatta 1882621 gtgccaatac cgagcgcata gctttcccat aaaagcttaa tcggcgtaaa tccgtgcgtc 1882681 atataatccc ggtaccgttt ctcaaagcat agtaaaatat gctggatgac gccggcccga 1882741 tcaatttttt ccccagcagc ttggctgagg cttgtcgcga tgtccttcaa ttcatctgga 1882801 aaatcattag gctgctggtt aacgttaatg ccgatcccaa tgatcactga acgtacgcgg 1882861 tcttcttcag cctgcatttc cgttaggata ccgactgttt tttttccgtt aatcaaaata 1882921 tcatttggcc atttaatatc cgtttggatg cctgctgcct cttctattcc ctgcacaaca 1882981 gctactgcag caagcagagt cagctgcggt gttttttgga gcggaatgtc aggccgcaaa 1883041 atcaggctca tccaaacacc gtttccttct tgagaatgcc ataccctaga cattcggccc 1883101 cttccggctg tttgtttgtc agccaccaca agggtgcctt ccggtgcgtt attattcgcg 1883161 agctcatgag ccgttttttg cgtgcttgaa agaacgtcat ggtaaataag atgctggccc 1883221 atcacttccg tttttaatcc aaaacgaatt tcgctttcac tgagttttcc gggttttttg 1883281 atgagccgat atccttttct tctaacggct tctacttcat aaccctcttt ccgaagctct 1883341 tcaatatgct tccacacagc agttcttgaa cagccgagag catcactgat tttttggccg 1883401 gaaataaatt cattgccggc ctgagaaaat aattcaataa ggtcttttct taatgttgac 1883461 cgcatgtctt cagccactcc tctatgtgtt tcttttgatt ggagagcttc cctgtcacaa 1883521 cagcctgctc gatccactgt aattcttctg acacccattt tccggccggc cggtttcgaa 1883581 gcgcaagcaa gtccttaccc gtgatatcaa gatccttaag gcttttgatc ggcaggtttt 1883641 gataagcgta ctgaatgtcc ttcagtttct tttcatccag tttttcgttt tgccgaagct 1883701 gcgatatttt ggccgctgag agcagtgctt ttttcccagc tctgtacatt gtcattgcgt 1883761 caaggctctg gccaaacgta tcggcaatgt gaatggcttc cttgatcact tttcccggga 1883821 gcttccaggc tttcaggaaa aggggcgcgt ctttcaaaac tatgccaagg ttaattaaaa 1883881 gagcagccca aagctcctca cgggatgtta aagagaagaa tggaaactca ctcgttgaaa 1883941 tcaggttttc tcgtttatga taaaaaccag gaagctcttc atacaatctc gtttgaatga 1884001 gtgtttgaag cgcctggcga gaagctcttc cctgcagcaa tttctcaaac tctatagttt 1884061 ttcgttcgac tgaaacatgg gagaggagtg atttttcttt cgcaatggct tcttctgttt 1884121 ccggtgaaag cgtaaagcca agctggctca taaagcgtac ggctctcagc atacgaagcg 1884181 catcctcttg aaatctatcc tcaggctttc caacggttcg aatcactttc tgatcaatat 1884241 ctttcttgcc gccaaaataa tcaagcacct tcccgtccgc tgtcatggcc atcgcattga 1884301 tcgttaaatc tctgcgtttt agatcctctt ctaatgatga gataaattgc acttctgacg 1884361 gtcttctgaa atcaacataa tcagattcag tccggaatgt cgtgacttca taggtttcat 1884421 cctcccagag cacaataatg gtcccgtgct ctttgcctac atcaacagtc cgctgaaaca 1884481 gccgttctac ttgatcaggt gccgcatctg tcgcgatatc gacatctccg atcgttcgtt 1884541 tcatatagct gtcacgaact gcgcccccga caaaataagc ctgatggccc gcttcgatta 1884601 agatgcggag cacgggaagt gctttgataa aaactttttc catgtgatca ctccggttct 1884661 gctaaatcgg cataaatctg ttcatactgg ctgacaattt ttttagaaga aaattcattt 1884721 tcaagcatct ctattgccgc ctttgtaaaa cgattgctta gctgttcatc ttctaaaatg 1884781 ctcatcgcgc gggctgttgc ggccgtaaca tcaccgacat ccaccaaaaa tccgctcaca 1884841 ttgtttttta taacctcagg gataccgcca atgtttgttc caatacaagg cactccgcaa 1884901 gccatcgctt caagcaggac aaggccaaag ctttcttttt cagatagcag cagcttcaaa 1884961 tcgctaatag aataaagatc ttcaacacgg tcttgatttc caagcattaa gacttggtct 1885021 tccaagccat attttctgat aagctcgcag gctgtcgatt tctccggacc gtctccgact 1885081 aaaagcagct tcgctttcgt tttgccagcg atattgcgga acacacggat gacatcctgc 1885141 acgcgtttaa cttttctgaa gttggacaca tggatgacga ctttttcatc tggtaaaatt 1885201 ccatgtttct ctttaattgc cgctgtgttt ttcttcagat acacgcgctc gtctataaag 1885261 ttataaatcg tttcaatttt tttctccggt ttaattaaat cgtatgtttc agccgcaagc 1885321 gctgaggaga cggccgtcac cctgtctgat gactcaatag caaaacggat cagatctttt 1885381 agagacggat cataacctaa caccgtgata tccgtgccat gcaaagtggt aacaatgccg 1885441 atattgcgtt tcagcatttg ttttgcaaga taggcgcaaa cggcatgcgg gagagcatag 1885501 tgagcatgga taatgtctaa attctcccgt tccgccacct cagcgatttt gcttgccaat 1885561 gtcaaatcat acggaggata cttaaaaaca gcatattgat taacctcaac ttcatgaaaa 1885621 tgaatattgg gatgatatgt attcagtcta aacggaatgc ttgatgtgat gaaatggatt 1885681 tcatgtccct tttcagcaag ctgcttcccc agttctgtcg caatgatacc tgagcctcca 1885741 acgctcggat agcatgtgat tcctattttt agttttctca ttgttcgccc ccaagcacat 1885801 catgatcaag catcagcatc cgtttggaaa agaaaccttc ggcatactcc acgcccgctt 1885861 ctttaccgta aagcttttct ctcgcttcaa cgatttcaat atacccattc gtcagaggag 1885921 tagaaacgga atcctttgac gggataaact ggcttttgta ggcgttgagg ctttgtttct 1885981 ttgcctctat tgtatccgag atatcaataa caaaatccgg ctgatgaaaa ccatttatca 1886041 tataatagta aaccttgctg actttatgcg ccggaaggct tttttcgtct ttatatttat 1886101 ggattccggc ggaaaagatc gcttcttcca ccagtgcagc cgcattgccg tgatccggat 1886161 ggcgatcctt tttatacggc ataaaaaccg cttttggccg acagattctg atgacagtga 1886221 caattgaccg aattgcctga tcactcatta ttaggccgcg gtctggaagc gttagctgaa 1886281 ttcttttatc tgcgcctaat atgcgggctg cttcagctgc ttcttcttta cgcaaactga 1886341 ccgtaccgtt agaagagagt tccgcttctg tcaaatcgca tatcattact tttttttcct 1886401 gtttgacaaa cttcgctatt gtgccgccca ttccgatctc gacatcatca ctgtgggcgc 1886461 caaaagcaag aacgtcagca ttatacattc ggctcttctc cccgaagaag gtcacggaat 1886521 tcgaaaacac cttcatcaag tgtgcgcaca agaatttccg cagtacccat atttgtggcg 1886581 agcggaatgg aatacacatc acataaacgg attaatgccg agacatccgg ttcatgcggc 1886641 tgcgcggtca gcgggtcgcg caaaaaaatg acaagatcga gtgcattggc agcgatcagt 1886701 gcaccgattt gctggtctcc ccctaaaggg ccggattgaa aacgttcaat ttgaagacct 1886761 gtcgcctcat gaattttcaa ccctgtggtt ccggttgcgt atagatcatg attctttaaa 1886821 atatcccgat aggcagtcgt aaattgaacc atatcctgtt ttttcttgtc atgcgcgatc 1886881 aaagcaattt tcattgttta tccccccgtc taatcaatga tattttctaa accatacaca 1886941 agctgatcaa tcttcatgac ttgttcgact gacagtttaa cgcctgacat gaaagaagca 1887001 cggttataag aatcatggcg tatctgaagc gtttggccat ccatgccgaa catgacctcc 1887061 tgatgcgcga tcagtcccgg aagacggacg ctgtgcaagc gaataccgtt ttgctccgct 1887121 cctcttgctc ctgggagaat ttctttttca tccggatgtc cttgctgctt ttctttacgg 1887181 acttctgaaa tcatttccgc tgttttaagc gcagttccgc ttggtgcgtc aagcttctgg 1887241 tcatgatgaa gctcaataat ctcaacatcc tcaaaatagt tggcagccat ttttgaaaat 1887301 ttcatcatca gtatcgcacc gagcgcaaaa tttggcgcga tgatggctcc gatccctttt 1887361 tcttctgtta aagatgtgag ctcttttaaa tcagcttctg agaaaccggt tgttccgaca 1887421 actggacgga ctccgtgctc taatgcaatt tttgtatgta cttttccgat ttcgggcgtt 1887481 gttaaatcaa tcaagacatc cggttgtgtt tctgtaaaac aggcatggat atctgtgtaa 1887541 atgaaagcat ctgactcaac aggcatcaca tcagataatt tttgctgatc gtatgtatgg 1887601 tctatggccc ctacaaggtc aaaatgtggt gttcgttctg ccaatttaac agcttcctgc 1887661 cccattcttc cacgcggtcc cgcaatgact aatttaattg tttcgtttga catcttgatc 1887721 tcctctactt tccttcttct tttctggtcc agcgatcttt atctcttgta ttaaatttat 1887781 gcatgactcg gtcgtgagct tcctctaaag agatatcaag agagttggct aaacaaacca 1887841 atacaaatag cacatcgcct atttcctctt ccatgctttt atcatcttca gtcgcttttt 1887901 ttggtttttc tccataacgg tgattcactt ctctggcaag ctcgcccagt tcttcagtca 1887961 gcctcgccat catggccagc gggctaaaat atccttcttt aaattggcct atgtaacggt 1888021 ctacttcagc ctgtatgtct ttcattgttt tatcactcac tgaacgaaac ctcctatcat 1888081 cctcttacat gttagctaat tcagatacgt ttgacaaatg tttaagcacg tttgctgttt 1888141 tctttttcat ccactataat ataaacgcta tctaatggaa ggaaaagggg ttttgtgtga 1888201 tgcttggaga aattagatta aaaaacatat tttttatttt aatcggagcg gcaatttttt 1888261 catttggctt ggttcatttc aatatgcaga acaatctggc tgagggcggt tttacaggta 1888321 ttacactttt gctttatgcc cttttccaca tcagcccctc tatatcgaac ctggtgttga 1888381 acattccgat tttttttatt ggctggcgtt tgctcggcag gacaatgttt gtttataccc 1888441 ttgtcggcac tgtagccttg tctttgttcc tcagcatctt tcagcgatat gaaatccata 1888501 tgccccttca gcacgactta gcgctcgccg ctttatttgc cggcgtattc atcggagccg 1888561 gactgggtat tatttttaag ttcggcggta cgacaggcgg tgttgatatc atcgcacgtt 1888621 tagtgaataa gtattttggg attccgatgg gcagaacgat gtttgctttc gatgcctgcg 1888681 tcatcatttt gtctttgctt acttatctct cctataaaga agcgatgtat acgctggtag 1888741 ctgtatttgt agcggcaaga ttaatcgatt ttattcagga aggcggatac gctgctaaag 1888801 gcgctacgat catctcttcg aaaaacgacc tgattcagaa aaagattctt gaagaaatgg 1888861 aacggggcgt caccattttg aaaggacaag gttcctacac aaaagaggat atagatgtac 1888921 tttattgtgt ggtgccgaaa aatgaattgg tgatgctgaa aagcgtgatt aactccattg 1888981 atccccatgc ctttgtagcg gtaagcgatg ttcacgatgt gctcggagaa ggatttacgc 1889041 ttgatgaaaa taaaaatccg cttccgcgct gacatgtaat agaaaaaagg cggctgaccg 1889101 ccgcccctca tccttattta gggtagtccc tttttttcag cttgtttttt tccgccttgt 1889161 actttctgta accgacatag gtaagagcag taatgatgat actgccggtt gtaatgatca 1889221 cccagagtaa agacggatcg gcatcatcct cctccaccct gtcaaacaca tttttcaggt 1889281 catgctgaag aagggaaagc cgttcaagct tcgtgctctc tgtcatttgc tgaaattcct 1889341 cttgctcaat aacatctata tgttttccga ctgtttcaag ctgatcctct gatacatcga 1889401 ttgtaagact ggggtaaatc aagtcatata aactgataaa ttcattccat ttttcatgaa 1889461 agcttgtgct tccattcttt tggacatctc gcttcagttc agtaaaagct tccataatcg 1889521 gtttttccag tgagccccaa agcgggtcag accgattgtc aaccgcatcc atcagcattc 1889581 tgaactgcgc ggctgctctg agtttttgtg tgtctgatgt atcagcttgc tttaaactcc 1889641 gaaccatatc attatagccc aatgtgattt gacgaatttg ggctcccgtt agcatggggt 1889701 cttgctgttt tttctcagcg gattttaatg ttttttcaaa atactccaag acttgaagcg 1889761 cctcttcata tttcgcctgt cgggtcattt gaaagactgt atcggataaa tcattcaatt 1889821 cctcgaggct tccccgctct gcagccttgg catttccatt ataaaaaata agtgcaatca 1889881 acaaacagat cgtcagcttt cgtttcatgc aggtccctcc cactctctct ccttacagaa 1889941 tatgaagaaa gggacaagga tagaccaaca ttgtctttac atcagctcaa gcttcgtttg 1890001 cttttttgag accacaagaa agtaagcaag cgcgattgaa aagatactta gccaaaatgt 1890061 tccgtatcct atttcagtca tataatcaga aagcatagag tattgcggca tcatatcaaa 1890121 caagtagtca atgacatcgt tatgcagtgt ccagactgca gcaattgcaa gatgccaaaa 1890181 tgaaaaacga aaatacggac tgtataatac gccttgaact gccattgcaa aatgcgaagc 1890241 aattagcatg tagccctccc acggcaagtc accagttact gcaagcacaa gaaaattcat 1890301 agccaccgcc cataggccat actttacgag ggtaactagc gcaagcgcct ctaaaagcgg 1890361 agcattccgt ttcatgagaa aggcaagcag cacaaacaga aagaaaaacg ttgctgtcgg 1890421 actgtccgga acaaaaatca ggaaacgggc cggtgtctcc aaaagctgcg gcaagtacca 1890481 atagtagccg taaaccgttc ccagaaaatt aatggctaag acaagaataa gcatcggccg 1890541 ctgccctaat acatattgaa accatttcac atcgaatcaa ctctcagtct gtaaaaataa 1890601 tatgtccata taaaaaagct gacgccgggt cagcttttga taataaaagt atatccttcc 1890661 atttgacaat tcacaatacg ttattttgcg gttgtttcag aaataaattt tgcaagttct 1890721 tcgagctgct tatcatttcc tttgaacaca cccgccggca ttttgccttt cccttctaca 1890781 gcgatttttt tgatttcatc cggtttcagc ccgctgtcaa ccaatgaagg cccggccgct 1890841 cctccctgaa ggttatcccc atggcaagaa atacagccct gttccttaaa aaccttatat 1890901 ccttctgcat tggtgtcaat gtcggcttct tttgtaattt tcccctgttc ttctgccttg 1890961 gcccagtcat gagtagcaac tgactgccac gtcaaaaata cagcagcgga aatggccaga 1891021 agcatcatac cgacagcgac cggacgcttc cacggccttc tttctgtccc tctgtctagg 1891081 aatggagcca aaagcagggc cccaaaagcg agacctggca taatcatggc gccgaccact 1891141 gtaaagcttc cggcggcgta ttcatacttc aacagctggt ataagaaaag aaaataccaa 1891201 tccggcagcg gaatataacc agtatcagtc gggtccgcca tccgctctaa aggcggctga 1891261 tgcacaatcg tcaaaacgag aaaaccgatg agaaagacag ctccaaccat ccattccttt 1891321 aacaagaaat ttggccagaa agcctctgtt ttacccggat actccgaata atccttcggt 1891381 atattcggct ttttttcagc cggtatcctt gagtcgccta caaatttcat ccctttgccc 1891441 cggtgcatgt catcccctcc cttttattcg cagatcaaga gtttaaagcg gtcctgaaat 1891501 cccctgcttc cggatcataa taaaatgtgc agccatcagc ccgaacaatg cggcaggaag 1891561 aaaaaataca tggatcgcaa aaaacctagt cagcgtttgg gcgcctacaa tatccggatg 1891621 ccctgcaagg agcgttttaa cttgcgttcc gatcaaaggc gtggcttcgg cgatctgcag 1891681 tccgactttt gttgcaaaca gagccttcat atcccaagga agcaagtagc ctgtaaagcc 1891741 aagaccgagc ataacaaaaa agatcagcac accgacaatc cagttcagct cgcgcggttt 1891801 tttatacgcg ccttggaaaa agaccctcag cgtatgtaaa aacatcatca caatgaccag 1891861 gctcgcaccc cagtggtgca tccccctgac aatctggccg aatgccactt cattttgcaa 1891921 ataatatacc gattcccagg catttttgat atcaggcaca taatacatcg ttaaaaacat 1891981 tccagataat acttggataa cggttacaaa aaacgtcagt cccccaaagc aatacacaaa 1892041 cgcagagaaa tgatgggcgg gattcacatg ttccggtact tcgtgatcgg caatatccct 1892101 ccacatcggt gtaatatcaa gccgctcgtc tacccagtca taaattttgt tcagcatgtc 1892161 acccttcccc cttaggcttt gcttttccaa gatacaggaa gccgtctttt acttcttgct 1892221 cataatgatc aagaggcgca agcggcggcg tgccagggac attggtgccg tccttttcat 1892281 agagtccgta atggcatgga caaaagaatt tattcgggtt tttaggatca ctattccagt 1892341 tcaccgtaca ccctaaatgc ttacaaattg gcgaaagtgc tacaatttca tccccgtttt 1892401 tgaagaccca ggctgatctt gactcttctg actcatacca ggcatcgact tgattaattt 1892461 taaaatcaaa gcgctgcggc tcttttgtca actcatcaac gctgacaacc tgaaccatat 1892521 cctgcttccc tgtcgatttt aataccgggt cgagtgcgaa gcgaaccata ggcatgagca 1892581 tactagccgc cataaaacct cctacgcctg tgagcgtata attcaaaaat tgacgtctgg 1892641 atatatcatg ttttccgccc atctcttctc ccccctctaa gtcacccctg caaactgact 1892701 aaaatagaaa atattgcaat aactctagac accctcataa tatatgaatc tctcagcaag 1892761 gtcaatatag ccaaaatatt gtttataagg aaatgtaagt gtttttataa agtgctccat 1892821 aactgtaaca aaacgttcaa aatttcagca gtgcgttcat ccaatatttt tctttttaaa 1892881 gagtcattta aatgctctaa tggaacagac gatgtaacaa tcattttgcc taacgcatcc 1892941 tcagctctcc aactttcgtc agatgtgagc aggacaacat gcggaaattc cgttatcagc 1893001 tcttcccgca aatccttaag cccttgaacg gttatttcat ttctatcaac atatgtataa 1893061 ggcggaagta aatatacccg tccctttaac tgcctttcaa gttcttctga gagaagctgc 1893121 gtaaactcgc ctttctccgc cgccatttta aaatggttat taacccttat gttaattaat 1893181 ggtatgacag cggtatcaat gtaatcctta gcttgtaaat agtccttggc atcagtgatt 1893241 ctccacctca tcgttctccc cctttacggc aacaagcctt gcaattcact gcaaggctgg 1893301 tcatattatg tgagctgatt taattggcgc gataattgtt caaatgcctc tttatcatga 1893361 cgatctaacg cgtcgtcaat gtcttttaat aatttttctc tttggaatgt ggaaatagcg 1893421 tgctctaaaa tctgttccgc caatccctga tcttttttat tctcaaaaag gtttttcgga 1893481 atatgcgggt tggactccag caccgccgca tattcaggtg agctgtaagc cgaacggaaa 1893541 ttaagctgga taaacaaatc ctgctgttta tttaatctaa tatcatgaaa agatttttcc 1893601 gcgtcggtag tcatgacatt ctctttatag aaccggaacg gaacttcttc aacacaatgt 1893661 gttgacatta taatgcctct cgggcaaaat tcagcctgct ccacaaaatg aaccttctcc 1893721 atgagagaat catggctcat taagtagttc aagatccaaa cgcactctcg gcgctttaac 1893781 tgataatggt ttaaaaacca acggataaaa tcttttttct cattgacaga aacaggggtc 1893841 tgcatgtaat tccctcctct atcgttcgta taatctatat acttatatgt tccacatgaa 1893901 tggttaatat tcctgcttat ctagaaaatt catcctcgat tcgcaaaatc gtttcttcaa 1893961 gctcttcatt ggctccgtcc atttcaagaa cctttttcaa aagcggcagc gcttcttttt 1894021 gaagaccttc ttctaatagg aagcttgcgt attcatataa gaaatctcta tcctcccggt 1894081 aatgaagata ggcagcctca aaggattgtt ttgcttcctc gtattgctct aattcagtat 1894141 atgcgcttgc aagataccaa ttgtatttag gatcttcttc accgtagctt cgaacctctt 1894201 gaataagatc aatgatctga tcataatcct cttctttgtg atacacggca agaagtgtat 1894261 gaagcgcctc gacaaagccc ggatcaagcg caagcgcctc ctgaagcagc ttcttcccct 1894321 cttctgactt cccgattttc aaggccattt tggcggcata aaggaaaagt tctttgttat 1894381 attcatcata tctgatcccc tcttttgccg tttttaatgc ctcttcatac attccttcag 1894441 cttcatagct tttcgagagc ggcatataaa gtgaagtata agatggatca agctccttta 1894501 aatcagacag ctgcttaata gctgttttca caagccccgc ctgtaaggct gtaaaaccat 1894561 agccgaaaat cgtattagga tcaggattct catcgacagc tttctcatac catggaatgg 1894621 catcctcaaa ttcacctgag gcacttaacg attctgccag tctttgatgg acattaacgc 1894681 ccccgatctc actctgctcc tcagccgttg ttttaaaata ttgaaccgct tttgcatagg 1894741 ctccctgagc aaagtaaagt tctcccagtg caaaatcaat aacaggttca ttgtccagaa 1894801 tggactttgc ctggaaaagc ttttgttcac tgacttcgaa taacccctgc atctgataaa 1894861 gatccgccat aagcagcaaa ctttccggat atgatggatc tgtttccgga atagtctcca 1894921 gcacagcgag ggctttttct tcttcgtcaa tatctattaa aagttcagcg tagaaattcg 1894981 tcagttctgt ttcatttgga tataaatcat gtagatcact aatcagtgaa atggcttttt 1895041 ctacatcgcc ccactcgtaa taaagctggg ctgcaatggc tttatcttca tcatgcagct 1895101 gtttttcagc cttcgagagc gtgttgaggc ctttttctgt ttcacctgct tcaactaatt 1895161 ttatggcttc ttgaatcaat gtattcaaat cggaccggtc ctttcttttc ctatacaaca 1895221 tcaaccatac aaaaaaagct ttatttgttc gggttaatct tatcataatt cagacgaatg 1895281 cccccggcaa ataagatgct tctgtacgga agggaattat tgagtcttat tagtttacca 1895341 aaagatcttg agatagaaaa tgaaaaaagg aagatcgccc tctgtacagt aaagcagctc 1895401 tttgacctgc cggcttgtaa gtaaagcaca tccccccttt tcgtttttct atccgttcta 1895461 taagacaagc tatgtttttt cgcctcgaat tatgatctgc ataaaaaatc ctgaagtaaa 1895521 acttcaggat tttttcgaaa gcttatttaa atgctcgaag aaggttggat aagaaacgtg 1895581 aatggcatcc gtgtgctcga tttcaatcgg ctcctccgtt atacaggaag caataccaag 1895641 catcattccg attcgatgat ctccgtggct ggacactgca gcgccgcctt tcaacgtttg 1895701 tttgccataa accttcattc catctgctgt cggttcaatt tcagcaccca gcttgcgaag 1895761 ctcagaaaca acagtatcaa tacggtttgt ttctttcact tttagctctg ccgcgtcctt 1895821 aataacggtg gttccttccg cctgagtcgc aagaagcgcg atgataggga tctcatcaat 1895881 taaacgcgga atgatatctc ctccgatttc aactgccttt agagatgacg tttctataat 1895941 caaatctcca taaggctctg caccgctatc agcagatggt ttgatttcaa gttttgcccc 1896001 catgttttga aggacatcaa taatacctgt ccgagtcgga tttaaaccta cgtttttcaa 1896061 tacaattctg ctgtttggaa ccatcgcgcc agcagcaagg aaaaacgcgg ctgaagaaat 1896121 gtctccagga acaaaaatat cagcagctgt cagtttctgg ccaccagcaa tggaaacact 1896181 cgtttgatct tcagaaagct taacgccaaa agcagaaagc atccgctcag tgtggtcccg 1896241 agatttatgg ggctctgtta cagttgttgt gccctcagcc tgtaatccgg ccagcaaaac 1896301 agcagattta atttgcgcgc ttgcaacagg tgatacataa tcaattcctt ttaatgaagc 1896361 gccgctcact gacagcggtg taaactctcc gccggctctg ccgtcgattt tagcccccat 1896421 ttttttcaaa ggctcagtca cacgcttcat tgggcgtttc gcaatgctct catctccggc 1896481 taccgcgctg taaaaaggac ggcccgccaa tattccgagc atcaggcgaa tcgttgtacc 1896541 tgaatttccg acatctaaaa ggctttctgg ctctttcagg gcatcgattc cttttccgtg 1896601 aatcacgaca tcgctgctgc tttgctcaat gtgaacaccc atttttctaa agcaatcgat 1896661 cgtgctcaga caatctgctc ccggcagaaa gtttttaact gttgttgtgc ctgccgctag 1896721 cgcgccaaac ataacagagc ggtgagaaat ggatttatca ccgggaatat gtatttctcc 1896781 atgtaaggtc tgcaccttat ctcgtttcat tttttccacc tcaatcagca taaaaagttt 1896841 catattccgc ccgggcttca atgcattgtt ctgccctttt gcggtcgtca tcagactgaa 1896901 aactgatcct taaaatcccg ttaatatcct ctcgtgtttc gataatgcgg atattcgtga 1896961 tactgatgcg ctccgcagct aagatcgctg ttatctcgga tattacaccc ggatgatcgg 1897021 gtacatccac atataaatca taaaatgcag gtatcgctcc cttctgccga agcggcagcc 1897081 cgtcgcgata atccttggct gttttaaaat aacgaaatag attttccgca tcttcttgtt 1897141 ctacatatgt acggatcttg tcaatttcac gaatccactc atcaaaacgg tctaagattt 1897201 tatctttatt atgtaataaa atatcccgcc acattgccgg gctgcttgat gcaatccttg 1897261 taatatctct gaacccgccg gcagcaaaac gcttaacaag cggatacagg ttttccgaat 1897321 gatgggtttg gtgaacaagg ctagctgcta caatatgcgg aaaatgactg attacgcttg 1897381 taacgccatc atgctcctct ggcgacattt ccacaaaatg ggcattcgtc cccttcagca 1897441 ggttttttaa ctgttccaca gcttgtttgt ccgttttctg gcctggcgtt aaaatataaa 1897501 atgcattttc aaacaggaac tccttcgcag cggccactcc tgatttatgt gaacccgcca 1897561 tcggatgccc tccgacaaat tgatagcggc taggcagcac ttgatcagcg taatcaacca 1897621 ctttttgctt tgtgcttcct acatccgtaa tcaaaagctc atgttcaatt cctgaatgag 1897681 ccagctcttc aagcataacc agtgtttgtt caacaggtgt cgcaatgatt actgtagctg 1897741 cctctttcac accgctaata aacgaatcag cacgatcgtc tatcacgcct aattttaatg 1897801 ccgctaccgc ctgttcatca gagatgtcga ttccgataat ccgtttgccg ggatgatttt 1897861 ttttgatggc tagggcaatc gaaccgccta tcaatccgag accggcgagc aatattgtat 1897921 ctttcatttg attcatacgt catcacctgg tttatagact aaagaggtga tatttgatca 1897981 cctcttataa aatttcagct aaaatggcaa gtatttcttc attttgctct tttgttccga 1898041 tcgtaatccg gagtgatgtc gggaaaccta atgcgtttcc tgaccggacg atatagcctt 1898101 tttccagcag agcctgaaac agttcatcag caggacgttt aaagtcaatt aacacaaaat 1898161 ttgtctgtga agggtagcac tttaaaccat gagttttcgc aaaatcataa tactgctgaa 1898221 ggcctgcatt attttgctcg acacaggaag caataaacgc ttgatcatca agtgctgcaa 1898281 tcgccgcagc ctggcccaga cggctggtat taaacggctc tctcgccggc tcaatctggc 1898341 gaatcaggtt ctcgtcagca attccgtatc cgactctgag cgctgccaga ccgtatgcct 1898401 ttgaaaatgt gcgcaaaatc atcaaattgg aatacttgct taagagcggc acggtttccg 1898461 ggtaatcctc tgctgttaca tattcataat atgcttcgtc aagaacgaca aggacacgag 1898521 aaggaacgcg ctccagaaat gcgagtaatt ctccttcaga tgtataagtg ccagtcggat 1898581 tattcgggct gcatatccaa acgacttgtg tctgttcgtc gatggcttct aacatggcgt 1898641 ctaaatcatg tgagccgtcg ggacgaagtg caatttcacg tacttcagca ccttcaataa 1898701 ccgcattatg tttatattgc ggaaaagtgg gggcagcagt aaccgtgttt gttttatcgt 1898761 ttaaaaatgc ccggcagatg atctgtatga tttcatcaga accgttgccg aaaataagtg 1898821 atgtttcgct gacattgagg tgcttactga gccttgtccg caaagcggcg ctatacccgt 1898881 ccgggtaaag ggctagctgt tgaatctcat gatgaagcgc ctcttttgca gcctctgaac 1898941 agccgtaagg attctcgttt gaagcaagct tcacaacttt atccaagcca tattctgatt 1899001 tcactgcttc aatcggcttt ccaggctgat aaggcttcag ctgttttaaa tgttctttga 1899061 tacgcaaatc agtcacctca ttttaaactg tacaagccgc taaacgccat tgcataatcc 1899121 tcaaactcct gcagcgcctg atttctcgtt tcagcgctga tgagccggtc ctttaattct 1899181 tctatttttc tgacgagcgc acttcccact acgacaccgt cactaatttc attcatcttt 1899241 atgacctgtt cacggtttga tataccgaac cctacagcaa ccggaacagt gctgagattc 1899301 ttcacagtac gaatgaacgg gtacacggat gaattgaact cattgcggac accggtcaca 1899361 cccagagaag atacacagta gacgaacccc tcggcttgtt caataatggt tttcaaacgg 1899421 ctttcgcttg tcggcgcaac taaagaaata tacgtcacct catggctttt acattcctct 1899481 tgaaggctgt tgctttcttc taatggcaga tccggaacaa gcagaccgtc aatatgattt 1899541 tcccgcagta aagcgaaaaa gtattctttg ttcaattgta acacaggatt ataatacgta 1899601 aagaggataa tcggaatatt cactccgttt tttttcattt ctccgcctaa ttcgattgcc 1899661 tttacgatat tcattccttg atcaagcgcc cgctttgaag cccgctggat caccggaccg 1899721 tctgcaagcg ggtcagagta tgcaacacca agctccaatg ctgtggcgcc tgctttttgg 1899781 agtgacttcg ccagttcaat cgaaacctca ggaactggat cgcccgccgt aataaacggg 1899841 ataaacaatt tttctgatgg ttgaagatcc aatttaaaca tgggctttca cctcttcttc 1899901 caatacattc attaatgtgt tgacatcctt gtctccccgg cctgataaac agacgagaat 1899961 gagttgaccg cgatccattc ctttggcgag tttgaatgct ttcgctaacg catgggcaga 1900021 ttcgattgcc ggcaaaatcc cctctttttc tgacaaaagc tttaatgcat ccaccgcttc 1900081 ttcatcggtt atactgtcat aagtgacacg gccgctttta tgcaaatatg catgctccgg 1900141 accgattcca ggatagtcga gaccggctga aatagagtag ggctcaataa tttgcccgaa 1900201 ctcatcctga atgagataag tcaatgaacc gtgaataacc cctacggttc ctttcgaaat 1900261 agtggcggca tgaagaggtg tatcaattcc ttttcctgct gcttcagcgc cgatcagttc 1900321 aacatcttca tttaaaaatg cctgaaacat acccatcgca ttgcttcctc cgcctacaca 1900381 tgccactact ttatcaggca tagtgccttc aatacgtttc aactgatcct tcgcttcctc 1900441 tccgatcatt ttttgaaatt cacggaccac ttgcggataa ggatgcgggc cgacaactga 1900501 tccaatcata taaaagtgat cctcacaatg ctgaacccag taccggatcg cctcatttgt 1900561 ggcatccttc aatgttccgt ttccgcttgt tacaggcact acctccgctc caagaagctt 1900621 catgcggaaa acgttcagag actggcgggc aacatcctct tcacccataa acacagtaca 1900681 ggaaaagccg aatttggctg caactgttgc agcggcaaca ccatgctggc cggcaccggt 1900741 ttcagcaatg attttcgttt tgcccatttt tttagcaagc agcgcttgac ctagcgcatt 1900801 attgatttta tgagaacctg tatggtttaa atcttctcgt ttcaaataga ttttcgcgcc 1900861 gcctaagtat tcagtgactc gatcagcgta tgttaatgca gtcgggcgtc cggaatagtc 1900921 ctttaacagc ttataatact cttcacgaaa agcgggatca tccttgattt gtttaaatgc 1900981 tgtttgtatt tcatctaacg gctgcatgag tgtttccgga acaaactttc cgccaaaatc 1901041 accgtatctg cctatttcat tcggatatgg atacatatcg gttcatcctt tcttctaaaa 1901101 gcctcatcag attctgatct ttttgtccgt ttttttcaat tccgctggca aggtcaattc 1901161 cttctggctg ccatttcaat aggcgtgtga tgctatccgg attcacgccg ccagcgataa 1901221 agcagcgttt accaatagcc gcctgctgat attccggcac acattcccaa gaaaatgcaa 1901281 caccagttcc gcctctagac ccttttacag atgaatcaat cacaaagccg tcaacattat 1901341 ctttaaagcg ggctatttct tgagttgtgt tatcttgatg gtgaagcgcc ttccatattt 1901401 cacagcctgt cagcttgcga agagcagcag catccgccgg tttttcatca ccgtgaagct 1901461 gaatgacgtc gagcttcaag ctcttggcaa tacgtgacat cgtctctatt gattcattaa 1901521 caaaaacacc tgcaacctgt ttttcgacac gaacttggtt cagccatttt ttcacatctt 1901581 ccggagatac ttttcgtttg ctttcagcaa aaataaatcc taggtaatca gcctgtgatt 1901641 ccgccgcaag ctgcaaatcc tttagtgacc gaataccgca atattttaat gccggtttct 1901701 tcacaacctc actccctaaa caaagcatgg attgctttac gctgagaagt ttgtctcatc 1901761 aatgattcac cgataagtac agctcgtgct ccatgttctt tgacaaatgt taaatgttct 1901821 aaagaaccga ttccgctttc gctgacaagc agtgattctt tcggagcaag agatgcgatt 1901881 tgttctgtct gcatgataga ggtttcaaaa gtttttaggt ttcggttgtt tatgccgaga 1901941 atatcaggcg tgaatacttt caatatttgt tctagcgttg ttgcatcatg aacctccact 1902001 aacacgtcca tctccttttc acctgcttca agatataatt catgaaggtg taagggatca 1902061 agcacttcgc cgattaacaa tatggcatcc gctccgattc ttcttgattc ctccacttga 1902121 agagaatcaa taataaaatc ttttctgagt acaggtatcg aaacagcgcg ctttacgtct 1902181 gataaatagc tgttttcccc ttgaaaaaac ggggtgtctg ttaaaacgga aagcgcatct 1902241 gctttcgcag tttcatagtc ttttgcaatc cgcacaggta caaaattctc tttaataagc 1902301 ccttttgacg gcgacgcttt cttcacttca gcaatcaacc cgataaaccg attcaggctt 1902361 gccagcgcct ctttaaatga acgtttttcg aaaggctgct ctaccggcag aaccagtgtt 1902421 ttcacttctt ctttcttttg tttgatgatt ttttcaagca tagatctctt cctctttctg 1902481 ctttagtcgt tcaagctgcg cggcagcgcc tccgcttgta atcgtctcta acgccagctc 1902541 cgttccttcc ttcagtgagg cggtaattcc cgccgtgtaa atcgcagcac ccgcattaaa 1902601 agccgtaata gataaagcgg aactgctgct tttattttca aaaatattct gaatgagata 1902661 agcgctctct ttcggagact gcacctgtaa atcttcaagt ctgccatttg tgaaaccgaa 1902721 atcttcgggt gaaacggtat actcccggcg ctctccgtcc tttaattcaa tcacgtcggt 1902781 cggtgctgta attgaaagct catctaaacc gtcacggctt gatacaaaca taacgtgctt 1902841 cggctgaaac gtctccagtg cgcttgccat cagtccagct ttttcaacag aatagacccc 1902901 aatcacctga cgcttcgcct gtaaaggatt gctgagcggc ccaagcagat taaataccgt 1902961 tctgaaacct agctcttttc tagtacctgc tacatgtttc atagacgaat ggtaaagcgg 1903021 cgcaaaaaga aatcccatgt tgtttgtttc aatgctgctt ttgacctttt cgggagtggt 1903081 ttgaatagaa acctctagct cctctaaaac atcagcgctt ccgcttttag aagagacaga 1903141 gcgattgcca tgcttagcga ttttcgcacc agctgccgag gcaacaattg ccgaggccgt 1903201 tgagatatta aaagtggaaa taccgtctcc ccctgttccg catgtatcaa caatatcagg 1903261 aagtccatcg actgtaagag cgtgtgcccg cattgccttc acaaaacccg caagctcttc 1903321 tggcgtctcc ccccgatgag caagaattga caatatcccc cccatttcag aaggagtcat 1903381 ttccgctgcc atcatcatat tcatcagcgt ttcagcctca ccggcagtaa gggtttttcc 1903441 gtcaacgcac aattgtagaa atctgttcat cagctttatc ctccttgcta tgaaacatgt 1903501 cttctgcaat atgaatcgtt ttcagcagcg caccggcttt attacagctt tcttcgtatt 1903561 cggcttccgg aacagaatca gcaacaatgc cagcacctgc ctgtatcgat gcaacaccgt 1903621 tctttacact catcgtgcga atcgtaatac aagagtcgat attcccgtca aacccaatgt 1903681 aggcaataca ccctccgtat gtctctctcg gtgttggctc gagttcttgc aaaagctgca 1903741 tggcacggat tttgggtgcg cctgttaaag tccccgccgg gaaagcagac atcagtgcat 1903801 cgacaggatg aacccctttt ttcaatcggc ctgtaaccac cgagataatg tgcatgacat 1903861 gtgaaaagga aacaattttt gtgaactccg gcacagaaac agaaccatac tctgctactc 1903921 tgccgatatc gtttcgggca agatcaacga gcatgtaatg ctccgctttt tctttttcat 1903981 ccttcatgag ctcaaccttc agtctctcat cttcagcttt gtctgcaccg cgttttctcg 1904041 taccggcaat cggatggatt tctaagtgcc cgtcttgaac gtgtattaac cgttccggag 1904101 agctgccgac tatttctctg tctagcagtt tcatataata catatacggc gaaggattga 1904161 cgatcctaag cactcggtat aactcaaaag catctgcttt tatcggcacc tcaaattttt 1904221 gtgataaaac accctggaag atatcgcctg cttttatata gcttttgatt ttttctacat 1904281 cagccataaa agccgatttt tcataattag aagatactgt ctcaaagctg ggtgtcttgt 1904341 atgaatcagc agaaagaaac agctctttta tgtttttttg gtccatcatt ttttcaatga 1904401 gattttgaag ctccagatga ttttgatgga atacatccat tttttcgttt tttgtttcct 1904461 ctccagtgag ccttgcatat tggataaagt ggacgttttt ggtttcatga tcatacgcaa 1904521 ttaatgtccg gcaaacaaac agcatacact tttccatgtc tgtttctttg gtatgcgaag 1904581 gaacagaagg ctcaatcagc gggatcatat catagcttaa gtacccgaca gctccgccga 1904641 caaaaggaat gccaagctca ggtgttttga ttttgtatgt ggtattcatc cagttcagca 1904701 cttcttttag ttcatttcct gtgtaaagag atttgctgtc ctgatcagcg gccgaaaaac 1904761 ggccctgctc ttctttaatt gtgagaaatg gattcaggcc gataaacgaa tatctggacc 1904821 aagtggatgt atcgtccttg ctttcaagaa gatacgtaat ctccctgtca agcttctcta 1904881 tcatttgaat gggtgtcagt gtatcgactg tgaaggtctc cacaatcggt atcgtgtggt 1904941 gggacaagct gtcctctaaa aatgcggaaa tgtttgattg gaaattcatt gctctcactc 1905001 cttatggcaa ggagaatgag aagatggcat gagaggataa aatactatat aacaaataaa 1905061 cccaaaagaa agacttcttt tgggtagaat aaacataatg tctcagctca actaaactca 1905121 ttctctgcta ccctattctc taactcaact cattctaatt gctttataca cactcttgtg 1905181 tatttctaag ctgttcttat cgtattacaa ttcagtattt tttgtcaatg ataaatcggg 1905241 cctcaatacg acaacttttt ctaaatatac atgtctgatc tgatcctgag ggacatctgt 1905301 ctggaccgtc atcatgactc ttatgcactt tttcagaccg cctgttacgt ccatttcctg 1905361 catacatgtt accggtacat actgccatcc tgaaagctcg cgaacagctt ttgccgggaa 1905421 aacagcgtgc aaatcaggtg tagccgacag aagcatttga acaacatctt ccggttttgt 1905481 atgattttct tctatgattt tctctaacag ctgtttagtt ttttgtaaaa tttcttcttc 1905541 agtatcccgt tcaactgtag ttgctccgcg aattccgcga atcatcatga tgtctcctcc 1905601 aatcgccatt tgttcagcca gctctcaagt tcatttctgg aaaatgtatg atcagcaact 1905661 ttccctaatt cgttgagcac aataaactga atcttcccgc cacgggtttt cttatcattc 1905721 atcatacggt tcaagagaac cgaagtttcc gtctcttttc tgatttgact tggataaccc 1905781 aggcttttta gccagctgac caaacgtttt ctgtccattt cacagcctac agtcttttcg 1905841 cttatatata aagcaaactg cattccgagg gctacggcat caccgtgagt gatctgccca 1905901 tatccatatt ccgcctcaac ggcatggccg agcgtatgcc caaagtttaa gtaagctctt 1905961 atcccctctt ctttttcatc ctgctgaacg acagacgctt taattgaaat gcctttaaaa 1906021 atcatgtcat tcagctgatc attagtgata tcacgcagtg agtggatatt cagcagctcc 1906081 tccagaaacg ctctgtcata gataaaagcg tgtttaatca cttctgccat tccggaccta 1906141 agctcttttt caggcagaga acgcaggaaa tctgtatcat agagcacggc tttcggctga 1906201 taaaacgcac cgattagatt ttttccaagc ggatggttca cggctacttt tcctccgact 1906261 gcgctgtcat gcgccaagag cgtcgtaggc atttggatga aatcaatgcc gcgcataaaa 1906321 gtggcagcca caaaaccggc aagatcccct acaacaccgc caccgaatgc gatgatgcat 1906381 gaggagcgat ccatatgaaa acgaatcgct tcactctgca attttgtgta catgtccatg 1906441 gattttgcct gctctccact cggtaccgtc acttttttca caggccattt ttcttgcagc 1906501 aaatggagca tttcatcacc atacaggcgg tccacttctt catccgtgac aaacataatc 1906561 cttgttaaag gcctgtttaa agaggttaat agttcgcaag ccttttttct gataccttgt 1906621 ccgataaaaa caggatatga cgaggaagca gtttgaacat gcagtgtctt cattaaaatt 1906681 ccctcgacag ttttctcata ttctccacat tttctctaat gcggtcaatt tgatctaatc 1906741 cgaattgttc aacgactgcg ttcgcaattt cccaagcgac agccgcttca gcgactacac 1906801 ttgccgcagg aacagcacag ctgtctgaac gttcaatgct ggcagaaaac ggttctttcg 1906861 tttcaatatc gacacttttc agcggtttat acaaagtcgg aatcggcttc atgactccgc 1906921 ggacaacaat cggcatccct gtcgtcatgc cgccttccag tccgccaagt ctgttagtag 1906981 cacgggtgta tcctttttcc tcgtcccaaa tgatctcgtc atggacttcg cttccatttc 1907041 gccctgctgc ctcaaatccg atgccgaatt ccacaccttt aaatgcgtta attgacagaa 1907101 cagcggcagc aagcttgcta tccagcttgc ggtcataatg gacatagctg cccacgccta 1907161 ccggcattcc ctcgacaatg acttctacta ttccgccgat ggaatctccg tttgcctttg 1907221 cttcatcaat ggcagccatc atttttttgc ctgcctcttc atcgtagcat ctgacaggag 1907281 actcttccgt tacacgctgc aagtcttcaa ttgacgtata ctctgttttt tcagctttaa 1907341 cagcgccaat ttgcaacacg tggcccgcca ccttaatgcc aagctcagaa agaatctttt 1907401 tagctacagc ccctgccgcc actctgacag ttgtttccct tgctgaagaa cgctcaagca 1907461 catttctcat atcacgatga ttatatttaa ttgcaccgtt taagtcagcg tgcccaggtc 1907521 tcggtctgga aatctggcgc ttcatttcct tttcttcatc ttctgtaatc ggagcggcgc 1907581 ccatgatttt tgtccaatgc ttccaatcgt tattttcaac tacgagagca attggcgaac 1907641 cgagtgtacg tgcatggcgc accccgctca taattttggc ctggtctttt tcgatctgca 1907701 tgcggcggcc gcggccgtgt cctttttggc gtctggcaag ctcaaaattg atatcttcct 1907761 ccgttatgta aagcccggca ggtacaccct caataatggt tgtcagttgg gggccgtgtg 1907821 attctccggc tgttaaatat ctcatgactt cttctccctt catcgcatta acgcttttaa 1907881 gtaagactac tataacatat ttttcagcaa aaagtcagtc tatctttttt gataaaagaa 1907941 tgtatcggct gggactaggc caaatttctc gggattgaag atttgctcgg tgctgccgac 1908001 aaaaagaact ccattcttct tcaagctatg tgccattttt aaatacagct cttccttcgc 1908061 gctttctgta aaataaataa atacattgcg gcacacgatt aagtcaaagt cttgttcata 1908121 acgatccgcc agcaaattgt gctttttgaa tgtaatattc tttttgattt ccgttttcac 1908181 ttcataactt ctatttgcgt tttgcgtaaa ataacgatct ttcacagata gcggcacttc 1908241 ctgtaaagac cgctcctgat aaacgccttt tttcgctttt tccaatgctt tttcatcaat 1908301 atccgtcgct aaaatctgat agcccggaag acctttttgc tggtccaaaa gcatggcaag 1908361 cgtgtatggc tcctcccccg ttgagcaggc ggcactccaa atttttaaag gcctagaggt 1908421 cttgattaac ggcagaattg cagtctcaag aacttcccat cttttataat tacgataaaa 1908481 ttctgaaaca ttgatcgtca ttctgtccaa tgtttcattt aagagagctt gatccttttc 1908541 caatgccgca gcaaagtcct taaagctttg gaaccccttt ttctcataaa gtgacgttag 1908601 ccttctcttc atttgtgctt ctttatatag tgttaaatcg actccggtta attgtttcca 1908661 tttcgttgta aatacgctgt atgtatccat ctctactctc ccagtctcgc tgtctttttg 1908721 tcctagtata gcttgtttta tcaggaaatt gtattgtttc aataaaaaaa tcagcttttc 1908781 agctgatttt agatcgttgg gaaaggcaga ggtctgatgc acactgccat tcaacccttt 1908841 attcacttta atgtaaacct ttacaaaaca gaacaaaaac cggcggcgtt atatgttgcc 1908901 ggctctgttg cttattttca caatgattaa tagatccagc ctgccataag ctgctgatat 1908961 gatactaatt cttcattctt aaagaaaatg ttaatctcgc gttctgcact ttcgagagaa 1909021 tcagagccgt ggatgatgtt ttttccgaca aacatgccat aatccccacg aatcgtacca 1909081 ggtaaagctt ctttagggtt tgttttcccg atcagctgtc tcgtcacttc aatgacattt 1909141 tcgccttccc acaccattgc gaatacaggt cctgaagtaa taaactcaac gagctctccg 1909201 aagaaaggct taccttgatg ttcggcgtag tgtttctcag ccatttgttc agtcactctc 1909261 attaacttgg cgccagctaa ttgtaagccc ttacgttcga atctagataa aatgtcccca 1909321 atgagctgac gttggacacc gtctggtttc accatgataa aagtcttttc catcatattc 1909381 tccaccccat cattatgtat gtataggctt tcacactgca caccgaaatc gtaacatctt 1909441 tctgataatt aatcaatccg gggcggagaa atttcttaat atctacaaaa attaaaattt 1909501 tcttttaccg atatattttg cgatggctgc aagagacgag cgtgcgcgcc ctcgaggaag 1909561 cgtgtttaat ttctgaaaag ctttctgcag atacatttcg cttactgcca tagatgcttc 1909621 aattgcatct gtttttttga tttcttcaat gattggttca agctgttcct gcgttgtctc 1909681 actgttaatc aatttaagct ggttttttaa tgcaggattt ttcagggcat acagcactgg 1909741 caatgtgacg tttccttgaa gcaaatctcc tcctacgggt ttacccagct cttcctcagt 1909801 tgaagtaaaa tcaagaatat catcaataat ctgataagac atgccgacgt aatacccaaa 1909861 ccagtacaat gccttatgaa tcttctcatc agctccagac gcaatggcac caagctggca 1909921 gctgaccgcg atcaagagag ctgtttttct tttgatacgg cggagatacg ttctgagatt 1909981 ttgttccatg ttgtatttgt ctttgatctg ctcaatttcc cctagacaaa cttcaacgat 1910041 cgtctgtgac aaaatcctat gggctttcgg ttcgttaatt ctcgtcatca tttcaagaga 1910101 tcccgcaagc atataatcgc ctgtgtacat cgcaatacga ttgtcccact ttgctttgat 1910161 tgtcggtttt cctcggcgaa gctctgcatc atcaatgaca tcatcatgaa ccaaagatgc 1910221 catgtgaatc atttccagag tgacggcgac atatttaatc ttattaatat cataatcgcc 1910281 aaacatgcca gaaagcagca cgaaaacagg ccgaatacgt ttccctccgg cctgcagcag 1910341 gtgaagacct gcctcgctta aaagcgggta atcggaacgt acggtttgtt caagttctct 1910401 ttcgattaca tcaatatcgt catttaaaaa agagtaggcc attttaaatt tcatatcatt 1910461 cacccaaaca tctgtgtttt catttccatc cgatatgcgt ggcagcgact ccgccagtaa 1910521 acgaatgata tttaacattt ttcaggcccg cctcttcaaa caggcctgcc agttccttca 1910581 ttccagggaa atctctggct gattcttgaa gccaagaata ttctttatag ctcttcgcaa 1910641 acagtttccc gaaaaacggc ataatatact taaagtacat aaagtaagcc tgtctgaatc 1910701 cgaacatttc cggctgggac gtttccagac ataccacctg cccgcccggc ttcactacac 1910761 gtctcatctc tttcagtaca gtcaagtaat cagggacatt gcggagtccg aagccaatgg 1910821 tgacataatc aaatgtatca tcatcaaaag gaagctccat cgcatttccg tgcagcagtt 1910881 caatttggct gaatccgccg tcttttactt tctgctcgcc gacactcagc atattttcac 1910941 tgaaatccaa gcccttgatc tcgccgcttt tgcctgccgc ttttgcaaga gcgatcgtcc 1911001 agtcagccgt tccgcagcag acatcaagtg cttttgcgcc ttcctttaca ttcatgatgc 1911061 gcatcgtttt gtcgcgccat tttttatgct gctgaaaact gatgacagag ttcatttggt 1911121 cataattttt atatattttt tcaaatactc cgtgtacgcg ctgttctttt gagtcctgca 1911181 taatggttta cccttcttcc actttctgat gataggtttg atcttggctg attgtcttca 1911241 gacggtttat taaaatgttc tgaataggtg aatttagagg cagaagtgac tcaatgctgt 1911301 ttttcgcttt tttaaaacaa tcttctaata tctcttcttt tgtttttccc agctgtataa 1911361 aactgccgat cacatccaga aatgcatcat ttccgttcat aagccgctta aatacaaaaa 1911421 aatcactcga cagctttttc cagcgcggga ggttgaagtg ttccgccaca cgatggaata 1911481 aagctgattc aacgatgccg acactttcga aaaaatcgtt ttcgtccttg aaagaacggt 1911541 catacagacg aattttatgt tcgttgattt ctttaatggc tgtagcaagc gtccgaatca 1911601 tgtagatatc cttcatttca gatagtaaag agtagtacag cccgctgaaa taatcgcccg 1911661 cgagaacagt caattggcgg tttttgtttt cgtctcgttt tatgactcta gctgtcgtca 1911721 cttcatcatg ggtatcaagg gcgctttgta caagcatcgc tgttacaata taattttctc 1911781 tgtcgttgtt ttttatgtcg gcttcttcaa ataaagcatg aaaaagaaga agcttatcct 1911841 catcaatttt cggcgcagaa atatgcttcg ctaaataagg atgagacagc ttttgtttta 1911901 atttcgtgtt cagattggct aaagttccgt agatgtcttg caaaaatatc acccttgtcc 1911961 ccaaattcac atttatttct taatctatgt atgagtttta tcttttcatt cgcttacgca 1912021 ggtatcatta tagcataaaa aaaagaaatt ggctgtatcc tcccgctgtt tgcgagcatt 1912081 tgcttttaac agcggggaca gccagcttat tttttttcgc ttttcatttc tccgtacgcg 1912141 gtttgaatca gtgcctctcc tctgacttta atggcagaag tatgctctgt aaactgagcg 1912201 atgatcactt ctcccttgtc gagtttttcg gaatggtgaa actttgtgtc tgttcctctt 1912261 gtcaggccga tcacattcac tccgtcctca acggctttaa tgacgacaaa atcacttgaa 1912321 tgcttttggt tcatttatag caccctctat ctttattagt cctggcgttt aatatgttcc 1912381 aatacttctg cacgggcagc ggcatcatct ttaaaaacgc ctctgactgc tgaagtcaca 1912441 gttttcgcac ccggttttct tacaccgcgc atcgtcatgc acatgtgttc cgcttcaacc 1912501 actaccatta cgccatgcgg atcaagcgtt tctacgatgc tttctgcaat tgtagaagtg 1912561 atgcgttcct gaagctgcgg gcgctttgca acggcttcaa cggcacgtgc cagtttgctg 1912621 agtcctgtga cctttccgcc tcgcgggata tatgcaacat gtgcttttcc ataaaaggga 1912681 acaaggtgat gctcacacat agaatgaaac gctatatctt ttacaagaac aagctcctca 1912741 tggttttcac cgaagatagt ctggaaatgt tcttttggat cttcattcaa gccggagaat 1912801 acttcggcat acatctttgc gactcttttc ggagtatcaa gaagcccttc tctattcggg 1912861 tcttctccga tcgcttctaa aatttgacga acagcttgtt cgatttgctc tttattaact 1912921 tctttcatgt tctatgtcct ccaccaatga atacatttaa tttcgattct agcacatatg 1912981 ccccgctaaa agcaaagtga atgccctgtc aggaagccca tgctcttgaa atatgaaaag 1913041 ccccttagaa aggggctttt ctgtgaagaa ataaagtgta tgtaagctag atgcatacac 1913101 gatctatatt cacaattatt ttccggcaac tgcgtcttta agcgctttac ctggtttgaa 1913161 agcaggtact ttgcttgctg gaatttcgat ttcttcacct gtttgaggat tgcgtccttt 1913221 acgtgcagaa cgttcacgca cctcgaagtt accaaaaccg atcagttgga ttttatcacc 1913281 gtttttaagt gcatctaaga tcgtatcaaa aacagagtca actgcttttg tagcgtcttt 1913341 tttagacaat tcgcttgctt ctgcaaccgc attgataagt tctgttttgt tcatgccttt 1913401 cacctcctcc caaaaggata cattcagttc gtttattatc atttcttcac agttcagtct 1913461 gattctaaac ctgtctcaga aaaaaatgag agcaagtaag agaaagacaa ttaaacggct 1913521 ttttaagaaa aactgcactc tgaggaatgt ttgtccaaca aagtgaagaa tttctgtatg 1913581 tagagtaaca catataaaaa gccatatcaa gcattttaaa gcgtcaatcc cttgctcgtc 1913641 aaggatttaa ggtgatttac cgaacgaata ttcctttttt tccttttttc atcctattcc 1913701 ttgatccttt tccattatta agagcaaaga aaaaagacct cccattctat aaagaggtct 1913761 accggtatta caggatgatg gcgattaagc cgccagagcc ttcgtttatg attctttcta 1913821 atgtttcttt taatttatac cgtgcgtttt caggcatcaa tgacagcttt gcctgaatcc 1913881 cttctctcac aattgagctc agcgaccttc cgaagatatc ggaattccag atggagagcg 1913941 gatcatcctc aaagtcctgc attaaatagc gtacaagctc ttcactttgt ttttccgttc 1914001 cgataatcgg ggcgaattcg ctttcgacat ctactttgat catatggatc gacggagcga 1914061 cagctttcag cctcacaccg aatcgcgagc cctgccttat aatttccggc tcatcgagac 1914121 tcatatcagc taaagcaggc gctgcaatgc cgtatcccgt ctgtttgacc atttttaagg 1914181 catcagacac ttgatcatat tctgttttcg catgggcgaa gtcttgcatg agctcaagca 1914241 gatggtctct tcctctgatt tcgacgccca caacttcttt taggatttga tcatatagat 1914301 gatcaggcgc gtacaaatca atttctgcca ccccttggcc cagctcaatt ccggctaatc 1914361 cggcactttc aatgaattca aactcgctga attggccgac aaccctgtct acgtcccgga 1914421 gccgtttaat atccttaacc gtttccttca cggactcctg atagctttca cgcaaccaat 1914481 ggttttcttt cagcaccatt acccagcttg ggagattgac attcacttct agcaccggaa 1914541 actcgtagag ggcctctctg agcacactca gcacatctga ttcccgcatg ctctctacac 1914601 tcattgccaa taccgggata tcatattttt cgcttaaatc ctggcgcatg gcttccgttt 1914661 ccgggtgata cggcctgact gagttgatga ccataataaa aggtttgcca acctctttca 1914721 gctcttcaat gactctttct tcagcctcta tatagtcact tctggcgata tctccaatgg 1914781 tgccgtctgt cgtaatgaca actccgatgg tcgagtgttc ttgaatgact tttcgtgtgc 1914841 cgatttcagc agcctcatga aatgggatcg gttcttcgta ccaaggcgta ttgatcatcc 1914901 gcggcccgtt ttcatcttca tatcctttag cgccgggcac tgtgtaacct acacaatcta 1914961 ctaatcttat attcacatcg agtccgtctg acacatgaac agacatcgcc tgattcggaa 1915021 caaatttagg ctctgtagtc ataatggttt tgccggctgc gctctgcggc agttcatcct 1915081 gcgctcgggc ccggtctgct tcgttactga tattcgggag caccacaagc tccataaatt 1915141 ttttaatgaa cgtggatttt cctgtacgga cagcacctac gactcctaag tatatatcgc 1915201 ctcctgttcg ttcagcgata tccttgaaaa tatcgacctt ttccaagtga tcccctcccg 1915261 gacttcctat ccttttcaat tttattaagc tctttcaatc aaacacagga cactatatgt 1915321 gtatgacgtt gtcctatttg aatatgacat ctttagaaaa tttctcatcc tcaatctatt 1915381 aatataaaaa aacctttctc cctatttgta tgcaagggag aaaggttcat tcctttttca 1915441 tatcattttc taaaaaaaca ggttcctgtt tgtcatttac cgtatatttt acagaaaacg 1915501 cggggacaaa gggggtttca tgccaaatca tatcctggat ttcagtcccg ggtttaaacg 1915561 tttttttgct ttttttgagg caagaagcca gctcagtccg gtaatcggca tatatttctc 1915621 cgtctccgtc aatcataagc ggcaaggaat tccctgagat tgggcttgtc actgtaagag 1915681 agctgccatc cccaagcttc ttctcatcga gtgtaaataa atcacgagat agcacatcct 1915741 tgtaaggcgg atattgatgc tcctgacgat acatttggat gcgcaatttc acatcgcgaa 1915801 ttttttctgc catctttaga tcaattaatt taacagtcgg atcgttctct acgtcaacaa 1915861 gcacgtattg atagtctccc ccgctttcaa atgccgtact tggaggttca gctatgtatc 1915921 ttggcgctaa ccggttaaag tctatcggat atttttgata tagcggtgtc gacatatctt 1915981 tggtttgaat aggaagcagc cctccatttg ccttttgaaa ttcatcaaca gcagattgaa 1916041 cctgctttag ctggtcttga taaggaatgg catgcacact gcttttccgt tcatttggat 1916101 ataaacatcc ggataaaaac acgactgccg caaaaatgat tgcgcacttc agtttaccca 1916161 tacagcactt ccttttacag ctttattcat tgacagggcc gctaaaaacc acgacaaaca 1916221 caataattcc agatatgagc atacacatgt atgcgaatga tgaaatcgca atcttcaaaa 1916281 aacggttttg gcacttaaag cggcttaaat agatggaagc tacagccaga aacatcagac 1916341 ccatggaccc tagagcaaac cacattttca tcaatgccag attcaatgac gtgcgcctcc 1916401 ccgatatgta agatataagc gttatattat attttaatat acagcgccgg aaaagatcaa 1916461 ccagattttc catccattga tagaacaaaa aaactgaagc aaagaggggg accttcgctt 1916521 cagtcaactt gactatattc acctgcacgt ttaagaaaca ctctcttgga cttcgatgct 1916581 atagtatgcg acttggcata cagatgcatc ctctattgcc taaatcggca aaatgtttca 1916641 ggagatccca agacttgggt gttcttctgt ttttcgggct ttcgttcaat taagatatgc 1916701 gattcaccat ttgattgaca cttttacttc acttgatttt caaacgtatt taccaaatcc 1916761 tccatctcgt gggttttccc tctcgccatt aaagattcaa cagcggtttc cactttttgt 1916821 ccgttgaata ggacctgatg gagagcttct gtaatcggca ttttaacatc atatttcttc 1916881 gaaagctgat aagccgcttt cgtcgtgcgg acgccttcga ctaccattcc catctcttca 1916941 agaacatctt caagcttgta cccttttccg agcaaattgc ccgcacgcca gtttctggaa 1917001 tgaacacttg tgcacgtcac aatcagatcg cctactcctg tcaatccaga gaacgtcaag 1917061 ggatttccgc ccattttcgt tccgagtctc gcgatttcgg caagtccgcg tgtaatcaaa 1917121 gcagctttgg cattgtcacc gtaccctaaa ccatctgtaa ttcctgcagc aagggcaata 1917181 atatttttta aagcccctcc gatttcaact ccgataatgt caggatttgt gtacacccga 1917241 aaattgtgat taataaatag atcctgcacc tcttctgctg ccctcatgct ctttgaagat 1917301 gcagtaacag ttgtggggtg ccgcagccct acttcttccg catgactcgg gccggaaagg 1917361 acaacgatat cttttctgac atcactcggg agctcaattt ccataatttc agaaatgcgc 1917421 agaagtgaat ctggctcaat acccttgctg acatgaacaa agactgcctt tttcgttata 1917481 aaagggacag cctgtctcag cacttcccga attgcttttg tcgggaccgc aacgataatg 1917541 acatctgcgt ctgaaacagc ctctttcata tctgttgttc ctttaatgga tgtagacagc 1917601 ttaacattcg gcaaataatc tttgttttca tgcaactcat taatttgatg aattaaatct 1917661 gcacggtgag cccacacaca cacttcattt ccattatcag ttagaactaa agccagtgct 1917721 gttccccaac tccccgctcc aagcattgtg acttttttca tgtttgattc acaccttttt 1917781 attttctagc tcttgcaaat attttgattg gtgtcccctc aaaaccgaac gcgtctctga 1917841 ttcggttttc taaaaaccgt tcgtatgaaa aatgcatcag ttccggatcg tttacaaaca 1917901 caacgaagct tggcggcttt accgacactt gagtcgcata gtaaattttc aaacgagaac 1917961 cgttatgagt cggtgtcgga ttcattgcca cagcgtccat gatgacatca tttaagacgt 1918021 ttgtttgaac tcgaagtgaa tgattttcac tagctttgat aatcgcaggc atcagagtat 1918081 ggatccgttt tttcgttaag gcagacataa ataggattgg cgcataatcc agaaattgaa 1918141 aatgatcgcg aatattttct tcaaattctt tcatcgtgct ctcatctttg tcaacagcat 1918201 cccatttgtt tacgacgatg acgacggcct tgcccgcttc gtgtgcataa ccggcgatac 1918261 gcttgtcctg ttcaataatg ccttcttcgc catccagcac aaccgccacg acttctgagc 1918321 ggtcaatcgc ttttagcgcc cgcagtacac tatacttctc agtcgtttca tagactttcc 1918381 ctttttttcg catacctgca gtatcgacaa tgacaaactc ctgctggttg taagtaaatg 1918441 acgtatcaac agcatctctt gtcgttccag ccacgttgct gacaataacg cgttcttcgc 1918501 cgagcatcgc attcacaagt gaagactttc cgacatttgg acgtccgatc agacagaatt 1918561 gaataacttc ttcattgtat ttcgtttcag gaatgttttt aaaatgctct gcaacggcat 1918621 ccagtaaatc acccagtccg agtccgtgtg ttcccgaaat tggatacggc tcgccaaagc 1918681 ctagcgaata aaaatcataa atattcgctc tcatttctgt gttatccagt ttattaaccg 1918741 ctaaaacaac aggctttttt gtgcggtaca aaattttcgc cacttcttca tcagcagctg 1918801 tcacgccttc acggccgttc accataaaaa taatcacgtc cgcttcatcc atggcgattt 1918861 cagcttgctg gcgaatctgc gctaaaaacg gctcatcacc gatatcaata ccgcccgtat 1918921 caatcaaatt aaaatcataa ttcagccatt cagccgagct gtatatccga tcccttgtca 1918981 cgccaggggt atcttctact attgaaattc tttctcccgc aatccggtta aagattgtgg 1919041 attttcctac atttggtctc ccgacaatgg ctacgacagg tttacccata gtacccttcc 1919101 tttcaatcca gccgctttca tttttacata aattttcaac cggttattaa aatcatttca 1919161 ttcactttta tgaaaagaaa cccttcagag gaagggctta actcatttat tatatcagtt 1919221 tttactggga tcacaactat tcttaaaaat gtttcacgat caaatacacg tcatctccga 1919281 ttctgtgagc tattccatca aggatcgcct caagattttt agcgaaaagc tccatctcct 1919341 tttggtcatt gcaaaaaaag acaggtgctc cccctgcaac ccgatttcga tttgtcgtga 1919401 ttacagacaa aatcactttc gtaagagatt cactcatcct atcaccttat cctgattctt 1919461 gataaattca gtcggcattc taatcgcatt ttccagggtt ggaacattgc taataatttg 1919521 aacagccgtt tcgggatggt gaatttgcgg gagaacaaat actgccactc tcccatcatt 1919581 taaatcccgt tttgcaattg gtgtcaaaga tggctctcct gaatcccgat aaaccccgag 1919641 cacattggaa acatcaaata aaatggcctg acgctgccct aaatttgcta tcgtcgctgc 1919701 tgaattaaag tttttcggcg tcaaaataaa gcccatgcca tgctttaaaa tcagttcctg 1919761 tttctctgga agcccgatat tcatcatata aatattatca acaaacagtc ccggaccgtc 1919821 aaagcgcggc tttatgtact cgatatctac aatatccttc aacacactgc ccgacataaa 1919881 cttcatggcc agtaaaaaac aaacgacagc cgctatgact gcagcccaga tggataaaaa 1919941 cacatacgca gaggttgtca aaagcgctgt aaagatcaca atataatttc tgctttcaaa 1920001 cgcaatggca atcccctcaa tatatgtgct tccccttgag acaagttcat acgaatccat 1920061 ttgcgtcaat gtgttccgct ccatgtttcg gacatctcta aattgcgtcg ctgccaatgt 1920121 taaaaatgtg atggccgtaa attcctcctg caaaagcgcc ggcataataa ttgcacctaa 1920181 accagccgct atcaacccca gtgcgatgtg aatcactttc ccatgaacat aggtcggata 1920241 ctggcggtaa tccgttttca gcatataaag ccttgtcgca attccggcaa tgaccccagc 1920301 aataatcgga tagatgtaat cactcatgac attttggtag ctcctttgtt tgatcttttg 1920361 cttttctgac caatctggct tgcgaggtgt tcgtatttag atatgccaaa cagcaatatc 1920421 atccccgcag aacacgcatt cagccattga aagccgccga cagccatagc cccggccaac 1920481 ttctggatca caaatgaata caccagttcg ccttggcaca tccctaggac aaataagaca 1920541 agctgcttct caaaattcct ttcaacagaa gctgttaaaa gcactattaa tataacagca 1920601 gcccactcag gttttatgat gaaccaaacc gggtcatata atgcaaaaag ataaacaaac 1920661 gcatacgcgg caacaagcgt cagatagacc atgatgtaac gaaaacgata cattcccaaa 1920721 tacccggcat agacacatcc gcaaacgaaa aacatcaaat atgcagcatt cagggaaaaa 1920781 tataaagcga tgtcatgtat gcttagaata atattagtta aaataaagac agagacggca 1920841 attcgtcttt tcgtcttttc aaaaataaat gttgtcagaa cccacagaaa ccacattgac 1920901 caatagtaat aaaattgttc cattttactt cctccatatt cccagtatgg agttcaagca 1920961 cattttttaa acaatcgatc tcacattaag gagtatgatc atgggaaaag acagacaaga 1921021 gaaaaaactc aaagcttcag gcagagtcga atcagatcgc gaccagtcca ttcactatga 1921081 cggagcgaca agccttgaac aaaacggaag attcaaaaag cgaaaatcat aatacaaaaa 1921141 gcccaaacca catatggttt tgggctttta tcatttatcg cacactatag cttgatgtat 1921201 tgacccctct ctctgtgagc caatgatggg tttcaccttt gatcacaagg ggcgcctttt 1921261 gtaaatcggc aattgttctg gcacccagca cggtcataat caactttaat tcctcaagga 1921321 tcagctgaat ctcctcaagc agtccttcct caccgctgtc agtcagcgct tttaaaaaat 1921381 gccctgccat tccggtgcaa gaggccccca gcgcaattgc ctttgccacg tcaagcgcat 1921441 cttgcagacc gccagaggcg atcatggtgc ttgcaggaaa ctcagagcgg atttccgcca 1921501 aacttgcagc tgtcgaaatg ccccacgaat taaaaaagga gatttgccgc tgtcttcgga 1921561 gattttcgat tttcgagaaa tttgttcccc cgtaaccgcc aatgtcaaca gctgcagcac 1921621 cagcttcata cagctttcct gctgatgctt tgctcatacc gaagccgact tctttcacaa 1921681 tgaccggtac actgacccgg ctgcaaattt gttcaatgcg tttcaatgcg ccgctaaagc 1921741 ttctgtcccc ttcaggcatc acaatttcct gaatcacatt gaggtggatc tgcagtgcgt 1921801 ttgctccaat catctcaacg gcttcctttg cctgagcagc cgttgcctcg cttcccaggt 1921861 tggcaaaaat cagcccgttt gggttttcct ttcgaacaat ttcataggaa agacgctctg 1921921 atggatcttt taatgctgac atttgcgatc ccacagcaag gggaattcca gcctgagaag 1921981 ccgctcgcgc aagcgattta ttaatctcat atgtaagttt tccgccgccg ccagtcattg 1922041 cattgataaa aatcggcgaa ctgcttgaaa gttcgccgat ttttgtggaa atatctactt 1922101 gttctaatgc aagatcgggc agactgacgt gaacaaacgt aatatcatca agacctgttt 1922161 cccgcttctg gccgatggac aaggcatgat tgatgtgttg tctttttcgt tctgctcgag 1922221 tcacgtttat caccaattat tttagtttat tcagcttatc tccgatcaga tctccaagct 1922281 ggaagccagt gcttgtttct tccttcgctt gatattgacg gtaatcttcc tggtcagctt 1922341 taggcgtttc ttcaagttca cgcatgctta atgaaatgcg ctcctcattt tcattcacat 1922401 caagaacctt cacttttaca gtctgtcctt cttcaaggac ttcatgcggc gtgccgatgt 1922461 gtttattgga aatttgagaa atatgaacga gaccttcaac acctggaagg atttcaacaa 1922521 aggcaccgaa gcttacaaga cgctgtacag ttccttcaag cacatcgcca ggcttcactt 1922581 tttcgccgat ttggttccaa ggtccaggca gtgtatcttt gatcgataaa gaaatacgtt 1922641 cattatcacg gtcaaccgat aacactttca cttttacttc ttgtccctct tcaacaacgt 1922701 cagacggctt ctctacatga gagtgggaaa gctgtgaaat gtgtacaagt ccgtcgatgc 1922761 cgccaatatc aacaaacgcg ccaaagtcag tcaggcgctg tactttgcca tcaagtacac 1922821 ttccaacttc aagagactga agaagttctt gttttttatt cgcttgttca ctttcaacaa 1922881 cagcacggtg tgaaaggatc acgcggtttt tatcacggtc aagctctaca acgagcagtg 1922941 acagtgtttt tcctttatag tcagtgaagt cttcaacgaa atgtgcttca acaagtgatg 1923001 ccggaataaa accgcgaacg ccgatatcaa cgacaaggcc gcctttcacg acatctttca 1923061 cttcagcttc aaacacttct tttgtttcaa attttttctc aaggtcttcc caagcgcggt 1923121 ctgcatcaac agcacgttta gataaaatca aagcatcgtc ttccactttt gttactttca 1923181 ggtcaagctc gtcgtctact ttaacaacat ccgatgcttt ctctacatga agacttgata 1923241 attcactgat tggaataata ccggattgtt tgacattgat aatttctaca tctacatgtt 1923301 tgtcttctac ctttgtcaca atccctttaa ctacatctcc aacctctggc acttgaacat 1923361 caatttgatt catttcctct gtcatttgaa taacctcctt ggtccaaacc tacacagctt 1923421 aattaaaacg gtttgaaagc tgaacatata acatgcccgc ttttagccga atatgtatta 1923481 aagaatcatc caaaaaagtt ttttgaatga tcaataaaaa gttttattag tattaacttc 1923541 taataaaagg acaggtttgt caagcaataa cattctatct tcgttgaaaa attcaaaaaa 1923601 agtggcattt gccatcctca gcgggacttt tgctccacag cctcgaggat tttatcagct 1923661 acctcttgaa tggaaagcga tgtcgtgtcg atttcaagag cgtcttctgc tttacgcagc 1923721 ggagatactt cgcgctctga atcaagcttg tctcttcttg caatttcctc aattaatgtt 1923781 tcgtagttga catcaaagcc ttttttcaca ttttcttcat aacggcgttt cgctctctct 1923841 tccacagatg ccaaaagaaa gatttttact tctgcatttg gcagcacatg cgtcccgatg 1923901 tcacgaccat ccatgacgac gccgcctttt tccccaagct gctgctggcg tttcaccatt 1923961 tcttctctga cacttctgtg cttggccgca attgaaactt ggttgctgat ttcatctgtt 1924021 ctgatcgcct cagttacatc ggtgccgttt acaaacactt tttgtccatc ttttgttgta 1924081 atcagctcaa tgtctgtccg ctttagcagc tcagccagtt tttcttcatc tgtcagatca 1924141 acgttttcct gtaaagccgc gtacgtaatc gcccgataca tcgctcctgt atcaatatat 1924201 atgtacgatt ttttctcagc cacaattttg gcaacggtgc ttttccccgc agctgccggg 1924261 ccgtcgattg caatcgataa tttcttttcc ataattcctc tccttgctct tttctcctct 1924321 aaggattgta tcacgaactt tatgaaaaag ggtgaaaaat tgatgaataa ttaatgtttg 1924381 aaggtttcaa tcctattgtt ttcctccatt ttatccaccc cttcatattg aatcactttt 1924441 gatacgtatg gttcaatatg ctgatagtga aaaagaaatt ggacaccaag taaaatgatg 1924501 gcctgaatga acaataattt gatcagcagc cgttcaaatg ttttcattgg agcacctcca 1924561 ttacaaatag tatggaagtg tttgccgatg tttattccat tcgggccttt cttctcttat 1924621 ttaactggcg cctgatgcag tattgaagca aagcctgctg gtcacctgct gcaatttctg 1924681 aatactctaa agtcattttt cgtttttctg acttggggtc attaaagatt cgtctgacaa 1924741 ctgcttctgt ttctatttga cgtgtgtgct cctcttcagg aagacggatg atcaggcgca 1924801 atgattcccc cgattgaaaa gaaaggccat cagctaaaac cacggcgatg ccgcctgcac 1924861 tgatgttata ggatagtgtg cggatctctt cttcatttcc cggctgaatt tgcacatcta 1924921 ataccgcatc agttcttaca tattggcggc gctggattct tttcattttt tcacggggag 1924981 gcatttcaag acagatcatt tgaagtttgt ccttcacttt accttttata cggcttataa 1925041 agcgataagg aacttcgtct tttcccacaa actctaccgt tacttccata tcgttatgta 1925101 aaatcacagt tcgccctgta actacatcaa caggatacgc gatcaaaagt tcattgtttt 1925161 cgatgctgac cgccttgctt tttgcctttt tcaattcatt ttcttctata tattctaaaa 1925221 gtacattttc tccaatctct atcattgact tcactctttc gcattcaata tactcacgtt 1925281 tttattaaag cacgtaatga aaaaaaggaa aagacattta gtcctttcct cctgttttta 1925341 taggtcttta tatataggtt ctgcattttt tagtttttca accttttctt ccgatccgtc 1925401 tttggcattg atatacattc tgaatgtgtc attttcaatt gtcccaagca tttcgtagca 1925461 taacacttct tgacctagtt catttgtaat caaagcgagc cttgtttctc tcacttgtac 1925521 atttttattt aatttagact ttgcctctgc ttcagtaatt gcaggcttag gtatggttct 1925581 ttttctgtga gatgtgagga agtctcttgc tgaaaagccg acaacctcac cgtcatccaa 1925641 ggccactttc atacgaattg cctcggggta catccggact ttattttcaa caggaacata 1925701 tgaaaataca ccgattttat catattgggc actttcatca atttccaaat catctgtttc 1925761 aaatccgttt ttctttaaaa atgcaagcgc tcggttcgat ccgtcattta aactgatttt 1925821 ctgatctttc acttctctgt tttggatcaa gtataccgga tgcccgccct tcttcgtaat 1925881 atccatataa atcactgctt tatggtctgg gtctttcatg ctgatgctat atacatcgcg 1925941 atttgttttt tttccgctct ttaccacttt aattgaataa ttgtcatctg gggcaaagcg 1926001 ctcagcaatt tgttttgctt cctgttcgga aatttgtttt cccttcagat ggctgaagcc 1926061 tttctcttct tttttcgtac tggtgaaact cgggccaaga tcagtgccag tggagaatgc 1926121 accaacattt ttttcgactg ttttaaagct gttgataatc gtattatcac tttgtttttc 1926181 gtcagaagcc agagccattt ctacgtccat ccagcgaagg tttttgctca tgacaaggtg 1926241 ctgaacatga cgcaattcat tttgtatatc ttcggactgc tgatatagct tatttagtga 1926301 tgtatactcg tttttatcaa gcggcttttg gtccaaatct ctgactgacg ttttatagct 1926361 gaaatcgccg atctttgata atagctcttc agttttatta aacggcatta atgtaagcgg 1926421 cagctgactg acgctgttat gagcttctga tgtaatcctc cacacatcga tcaatgcagg 1926481 cgacagtgat ttttggctgt tcatggcaag tgttgttccg attttatcat gaagctgatc 1926541 cacctgatag gtaagctcat gaaacgcccg ctgatagtta ttttcagcat gaagaagaac 1926601 tgcgtctttt tcctggtgtt ctttgtatcc ccagtagcct gtaccgacta ttgcaatacc 1926661 aagcacggcg attaaaattc ctctgatcat ttatcacacc tctttttatg ctttctcata 1926721 tctgctactc acagaaaatg tgtttaccga ttcttttaat ctgcggacgc ccccaaatcc 1926781 acggacttgt agccgtatcc ggattaaagt agtaaagtgc ttcctctgat gggtcccagc 1926841 cattgatggc atccagcact gcttctcgtg ccgtttcatt cggctgcatg taaatttgtc 1926901 cgtcggctac tgctgtgaag gcaagcggct caaaaataac ccccgctact gaatttggaa 1926961 ataacgggct gttcaaacgg tttaaaatga ctgctgcaat agcaacctgc ccctcgtacg 1927021 gctcgccccg ggcttcgcca taaaccgctt gagcaagcag cctgatatcg ttgttggaaa 1927081 atccaccagg catgttcgct gctaccgcat cctgttttct tgcttttgct ggtgtattgt 1927141 tttgctgttt attcgcattc gctttaggct tctgcgttgt tttttccgca ggctgtttct 1927201 gccgtgcttc tgcttgttgt cttgcctttt gtgttgctgc ttttgatggt ttcgtctgat 1927261 actttagcgg aatttttccg taatgcgtga atgtattccc tttattgagc tgttccatga 1927321 catattcacg atagtatttt gatttacata ttaaggtttg ctttgtttta gctcctacaa 1927381 ggccgtcaac ctcttttaac ccgaattgat cctgaaaatt tcgaactgcc cagtacgtcc 1927441 cccatccata aaccccgtca atttttccgt tataatatcc gttgtattga agacgcgcct 1927501 gaagctcgac cacatcatcc cctgttgccc ctctttgaat gacctgattc gaaaaggcag 1927561 agatcgtttc agtattaata aacgtcgtta ttgtaaagga aaaaaggatg agacatgcca 1927621 taatcgatcc tttggacttc atcttttcaa gcctcctact gcaaattttt aagtgtaatc 1927681 gtattttctg taacgaggtt atttttatac actctttcct tgttatccct cagaacataa 1927741 aaactgcaca caaaaaagcc gcacggttgc tgtgcggctt ctatacttgc atcatattaa 1927801 cggaacgggc ttttttcgct ttacgcaaac caaaccacca taaaaatacc ataaatggaa 1927861 gcatataata aatccaattg ctaagcgctg ttaggataaa atcatatgat ccatgcaaaa 1927921 gggatgggac aactaaagaa agagtaagcc actttacacg cgccttatca gcggaaaaac 1927981 gggcttttcc aaggtaaaat cccattataa cgccaatcaa ggcatggcat gaaacaggca 1928041 gcagcgccct gacaaacgca tgctccacgc cgtggccaat taaataaaga atattttcga 1928101 gggttgcaaa accgagtgat acacttgcac cgtacacaat cccgtcataa tgctcatcaa 1928161 agtgggcgtg cgggtaaaca ctgatcatca gtataaacca ttttaatgat tcctccaaaa 1928221 accccgaaga taaaaaagaa acgaaaaagc ttccgcctcc tacattctct ttttcaagta 1928281 catactggat aaacatgatg ggaaatacaa gaacaacccc gagaaaaaac gaccgtagca 1928341 ccatatgtac aggttcatta tcatactgat cttttaaata aaaataactt aataacgcga 1928401 tgccgggggc aattcctgca gagatgattg caaacatcag gcaacctctt tcctttatat 1928461 tcctacatct atcctaccat gttgtttaaa attttacatc tgtctgcact taaaaaaaca 1928521 aaaagagcat acgaatgcat catatgctcc tcatctttaa tggttttctc ttttggcgat 1928581 ttccgctgcg atatgccccc cgtgaaacct gccgttttca ataaatattt catttgcatt 1928641 gtttcccgca gcaataacac cggcaataaa gacaccttca acgttcgttt ccatcgtttc 1928701 ttcgttgaaa aatggacgcc ctgtttcttt atcaatttca acaccaattt tttcaagaaa 1928761 ttgatgatcg ggatgatagc ctgtcatggc aaatacaaaa tcatttttaa tggtaatgag 1928821 ttctttctct ccggagcgaa acacaacttc attctcggtg attttttcga cacaagctcc 1928881 aaattccata cggattgtac cgtttctgac gagagcttca aattccggca gaatccacgg 1928941 cttaatgctc ggagaatact cattgcccct atataaaact gtgacacgcg ccccagattt 1929001 cacgagttca agggcggcgt ccacgcttga atttttcccg ccgatgacaa caacatcttt 1929061 atcaaaatac gggtggcctt ctttaaaata atgaaatact ttcggcaaat cctcaccggg 1929121 tacgcccata tagtttggat gatcataata gcctgtggcg atgatacaat atggcgtcgt 1929181 gtaggtctct tttgacgtct caataacgaa tgtgttattt tgcgttttcg tcactttacg 1929241 caccatttca aacgcattaa cacggatgtt tttccgttta acgacttccc ggtaatacga 1929301 taaagcctga attctgacag gcttcctgtt ctctgtaata aatgccacat ctccgatttc 1929361 gagcttttca cttgaactga aaaaggtttg atgcgtcggg taattgtaaa tactgttaac 1929421 gacattgcct ttttcgatga cgagggcatc aatgccaatt tgttttaggt gaatggcagc 1929481 agatagtcca caaggtcctc cgcctataat aattgctttt tcttgaatca tttctgtcaa 1929541 ctcctgcgat tggcatttca cttcatattt tctatttccg aataaaaaaa tctcctattt 1929601 tatcatagga gattttttat ttttatgcaa atcatcaact tatatccagc ctctaaaacg 1929661 cgaagcttca gccattttgc gaacgccgac catatatgca gcgagcctca tgtcaattct 1929721 tcggttgtta gccatttcgt aaatattgtt aaatgatttg accatcattt tttctaattt 1929781 ttcttctacc tcttcttcac tccagtagaa gccttggtta ttctgaaccc attcaaaata 1929841 agaaactgtt acgccaccgg cacttgccag cacgtctggt acaagcagaa tgtcccggtc 1929901 tgaaagaatt tttgttcctt caagcgttgt tggtccgttc gctgcttcaa cgacaatttt 1929961 agcccggata ttatgggcat tttcttctgt aatttgattt tcaatcgcag caggaacgag 1930021 aatatcacaa tccagctcca gcagctcttg gttggtaatg gtatcgttga aaagctttgt 1930081 tacggtaccg aagctgtcgc gtcggtcgag taaataatcg atatcaaggc cttccggatc 1930141 ataaagtccg ccatacgcat ctgagatgcc gacaactttt gcccccgcat catgcataaa 1930201 ttttgccaaa tagcttcccg cgtttccgaa gccttggaca acgacacgcg cacctttaat 1930261 atcgatgcct ctcttcttag ccgcttcttt aatacagatg gtaacacctt ttgctgtcgc 1930321 agattctctc ccgtgagatc cgccaagcac aagcggtttg cctgtaataa atccaggcga 1930381 attaaattca tcaattcttg aatactcatc catcatccaa gccatgattt gtgagtttgt 1930441 aaatacatcc ggtgccggca cgtcttttgt cgggccgaca atttggctga tcgctctgac 1930501 ataccctctg ctcagacgct ccagctctct aaacgacata tcccttggat cacaaacaat 1930561 tccgccttta ccaccgccat atggaagatc aattatgccg cattttaaac tcatccaaat 1930621 tgaaagcgcc ttcaccgcct tcacctcttt ttctgttacg ttcgggtgaa aacgtatccc 1930681 gcctttcgtt ggaccgacag agtcattgtg ctgcgcacga tatcctgtga aaatctttac 1930741 tgaaccgtcg tccatacgaa caggtatttt taccgttaat aatctcatcg gctcttttaa 1930801 caattcgtat acctcttcgg gatatcccaa tttttccaga gccttatgta ttacggtttg 1930861 ggttgatttt aatacatcaa gtttgtcctc ttctgtatga ccggtgtttc gatcggctgc 1930921 catttgagtt aacctcctag aatcttctgt ttctcacatg ctccctttca gagaatagta 1930981 tacaccttca tatgatctgt gcatagaata aacgttatgt ttttccatgt tttttaacga 1931041 aaaaaaactg ctgaaatcag cagttttccg ttgcattctt atgaaaaatg agtttgtatc 1931101 gtttctacgg cattaccgtc cataatgagc ttaccatact cttgcaggcg ataaatcgtt 1931161 aaagttgtcg gattgccgta ttcagccaga accgccacaa ccccttcagc cgtatgtgac 1931221 cctagatctt caaggcttaa aaagtactgc ccgtcatagt ggtagacagt tccccctgtg 1931281 ataccgattc gctgtaagct ttctgaaagc tgaatgatat cttcaaagga atggaattga 1931341 tatatgatgt ccgcgctttc atcaagcttg acttgcattt cgatgtaatc atcatcatac 1931401 tcatcgtctt ctgaatcggc gtcttggttc tttgttacaa tcacgaccat cccttgtgct 1931461 tggagagaat acacttccac tgcaatcggt ccattcgctt caaagccgag ctctgtattt 1931521 gcttcattca tcatatcttt aaataactgg tggactttaa atgagtcctt ccagaggtct 1931581 tcttttgtca atccccggtc tgtcaaatca tcgagggtta aaaagatttt gatcttatta 1931641 taattcagac gctcaagccg cataacgttc cctcctgcct ctacttgcac acaaatcata 1931701 taacacatta tatgagatga tgagtcatag gttcttaatt gttatcagtt tacactgagt 1931761 tcactagtaa gacaagcaca atgcagtttt tattgccata cggatttttg ctttttagaa 1931821 gttattctgg cccgcaaaga gtcacaatgt gagtttcagg ctcagcacct aaacgaagag 1931881 gcacttttgt cgtgccgtag ccgttgctga tcagatatgc cgcgttttta acaatacctg 1931941 ttttccccag ttcataagga ccgaattttc caaacctgat ctggcctcca tgggtatgtc 1932001 cgctgagtat cacatcaata ccgtcatctt cattgatttg ttcatgaatc tccggattat 1932061 ggcaaaccag aatattcagc tggctttcat caagttcttt gatggcttcc tcataatgat 1932121 ccatctccat cctgatatca tcaacccccg caatcgcaat cgtatgccca ttgtatgaaa 1932181 acgggactga ctcatttctc agagtgatga cgccgtgcgc tttaaatatg gaatacagct 1932241 tatgctgcct gacttcataa tcattattcc cccacacaaa cacgataggg accccgaaat 1932301 gtacgagcct tttgatgttt tcctcgattc tcgcactggg caccccgccc tcagctaaat 1932361 caccgccgat tataaccaag tggggggcat ggcttcgcgc tttttctaaa aggtcttgat 1932421 cgatgagacg tttgtgaatg tctgaaataa aaaagattgt cagaggcggc ttgcccttca 1932481 tctttgataa aggaaacgta tgtgtcttca aatgattgcc ttttgctgtt gcatacattt 1932541 ttgccgtcat tgccgctgcc gcaacagtta gtacaccggc aattttcact gatagcttca 1932601 taaaaaactc tccattcttt ttagaactta tcaataagac ggacaataaa aaaagacgtt 1932661 tctatcgttt gagaaaacgc cccattttat ttactttcaa aatatagatt aatgtcatat 1932721 ttgtgcttca tcatatgaaa aacagactct ctcgccttcc atttatcggg ctgcggccag 1932781 agatcagtgc ttttctgaat aatttcacat ctcagtttat ggaaatcagt ctcggatttt 1932841 tcttcctttt tcttgaaata atatgaagtg cagtaggcaa aagcggttgc cagcatccaa 1932901 aataaataaa aggtatggct aagtatttct tgaagtataa gctgaggctc cgggcttttg 1932961 atcatgatca taacacataa taagcctagg cagataagtg aagcccatcg ccatctgcgg 1933021 cattgtgctg cataattttc gaatttttgt tttcgtttta ccagcgcttg gagcatctgt 1933081 ttggtcggcg cgtctgtaaa ctgatccagc tgattccata aggattccat acgcttcaca 1933141 ccttgtccat tttcattgct acaatatatg aacgtaaaat aaaaataata ccctattcat 1933201 ccattaaagg gatgtccaaa acttgtccgg tgtaaacatc atttccattc agatgattat 1933261 atgctcgaat tttttcttct cctgtccggc ttttataata cttcatggaa atgcggtata 1933321 gcgtttcttt cttttggacg gtgtgcttga caacgcgatt cggcacattt tgaactggct 1933381 cagctggctg ttcttgctgt tgtactgttg attgggaaga ggaagcagcc gcggcggttg 1933441 cttcctcctt atttggcgag tcttcttttt ccgctacagc agtctgtttc ttatcagcag 1933501 ctgtttgctc ttttggcttg gaatcttctg gctctttttt tgactccttc tgcagtgcgg 1933561 tttctttagt gtctgcggta tcgtttttat cctctgattt cgggacaacc tcatatttgc 1933621 tttggctgct gtcaataaaa acatcttcat aatcgtcatg attatccggg tggctcttta 1933681 gataaaataa ggtgactaaa acgataaccg gcacaaatac aaatattact gcgagtactg 1933741 tgaataatgg cgtttttgtt ttgccttgct tttttttctg ttctctttga ttttttacag 1933801 attgtcttgt cggaaggctt tctccatcat cgacataatc gtccgccaat gcggcgtttt 1933861 gatcttcata aagattctgg gcttttcttc tctctactct cgacatgttc gtcatgttta 1933921 tccctcctca catgttcaaa acgaatctga caggcaaaca cggcatcaat gataaaatgc 1933981 gccgtcatcg gaacaaataa gttgccggtc cattcataca tcagaccgag caaaaagctg 1934041 attgctgtca ccataataaa taacagccat tttgacaaat accgaaagtg cagagcggca 1934101 aatataaggc tggccgtcca taaaccgata tgagtctgca gcactcctct gaataacatt 1934161 tcttccgcga aagcaatcag aagcgttaaa aatataatat gagggattga cctcttactg 1934221 aatatttttt tattgattcc gccgtcatca tataaatgag acggaaacca tttcattact 1934281 gccatatcgg ctaaaataac aataacagct atagaaacac cataccagat gattcgcata 1934341 tcgcgaatgt cccagagctt taatacgtcc cgtacatcct caaaaaagaa cagtcctgct 1934401 gcagcagcgg caaagatgat gagtagctgc gtcaaatata actgcttcag catatcatgg 1934461 tcagtcatat gctgaatata atctttttgc tgtttcagtt cagctcacct acagtctgca 1934521 agctgaatat ccggtgcaat tccgaactcc agctgtctaa tggcgccatt ttactccgtt 1934581 cccctttttg ttcatacaag gataaatcaa aaccgcaatg tgaacagcac gggaggtttc 1934641 cgtcatcagg ctcgtatgat tcatcaaagt aggttaacag tgcctgcctt aaacagccgt 1934701 cacgctgaag caaaaatgat acacggtgca ttttttccag cttcagctcc atgcgatatg 1934761 aaatttcttt cttcatcagt tcaactgatg tttttccctg cataaagaga tgaatcatca 1934821 tacgggcctg tgtctctccg acgccatact gaagtaatac gtcacgcagc cttctctcat 1934881 cccgctcctc cgtcttctct agcacacgga ttacgtcggc gatttcttca gctgtgacac 1934941 tctccatctg gataatttgt tcctgcaatt caaaatcccc tggcgcccgc agcaaaatgc 1935001 tgacactcgg ctttccgtcg cgtcccgctc tgccgatttc ctgcataaaa gcttctgccg 1935061 tctgcgggag atgaaaatga atcacatatc tgatatcagg tttatcgaca cccattccaa 1935121 acgcattcgt acaacatatc acatcaagct ggttatgaat aaactgctgc tgaattaaaa 1935181 tcctgtcccc tgactccaaa ccgccatggt aaaagtcggc tctgctgctc gttttgcttt 1935241 taatttcacc cgctaattcc ttagcccatt tccgtgttgg acaataaaca attcccggac 1935301 cttgcaggtt ttcaaccagc tgaatgaccc tatctatttt ttcggcagta tccgccgcat 1935361 tttcaaccct cagtgcgatg tttgggcggt tgactgagtt gagatggcgt acagcatgct 1935421 gcagctccag caggttcatg acatcttgca gcgtttcctt tgtagccgtg gcggtcaatg 1935481 ccagaacggg tgggtgtcca agtttttttc tcagctgtcc gagctttgaa taatcaggcc 1935541 tgaagtcgtg tccccattca gaaatacaat gcgcttcgtc aataacaaat aggctaatcg 1935601 gaacgctttt caatttttcc aatacatatg gagactgtaa agcttcagga gacaagtaca 1935661 aaaatttata tcgatgaata tgttctaaaa caaattgtct ttcctgcctg ttaagcatgc 1935721 tgttcaaagc tgcagcacgc ttttcccccc gggctttgag ctgctgcacc tgatcctcca 1935781 ttaaagaaag cagtggagaa acgattaata ccatgccatc aagcatataa ccaggcagct 1935841 ggtagcaaag cgatttccct cccccagtcg ggagcattgc aatggtatcc ttcccgctga 1935901 gtatgctttc aataatgtcc tgctgccctt ttttaaagga agtaaaacca aaaaactgat 1935961 ataacgtttg ctgtaattta gtcatattgc tgcacctgct ttgtcaatgc cagtctgatt 1936021 tgaaagtagc tgaaccgctg ttccagcccg tcgcgaattt gtttgatttt attcgtccgc 1936081 atccgtttgg caaactctgc gatttgaagc tggtcttctg ctgatacata gtcattaatc 1936141 ataaacgcag gctcatggag agaaatctcg acaatgtggt cttcaatcgt cgctgttttc 1936201 agctttctga tttcagcaat tcgctgtatc ggaaaccctt gtttgaccat ctgccatgtt 1936261 ttcctcgtcg actctgtcag ggcattatct aagtgcacat cagaaaggag atcctttaac 1936321 aaagcatctt cacactccgg aagagaatga ataaaataat gtaccgaagc ccaaaacatg 1936381 atatagacat accattcgtc ttctttcagc gtatcagcaa gctgcctgct cgtataaccg 1936441 atccgatggt gcgaggttaa ggagtagaca aaaatttgcg ctgctttgtt ttcaatcttt 1936501 ttcaaatgcg cctcaagcat ggcaaaaagg ctttttgcca tctctatatg atccgtatgc 1936561 cgggacaggt atttctttac ccagtgaagt gtcttatgat cctttgtgac agggatatac 1936621 tgcctgctcc cttgctgttt atgggatagg acctgcacaa gcagcgaaag ccttttccaa 1936681 agcacgccgg cagcctgctg ataatgagcg ccgtgacaat gaacgggcca aggccgctcg 1936741 ctaagggcat gtctcaaaac tgctgcgccg ctggctgtca ctttgtatgt atctgattca 1936801 gacattggcg cgagatatga atgcttttca agcttgtcaa gcgacgcaga aatatcgctt 1936861 ctcgaacatt ttgccgccat tccaaagtat tttgcagtct gaaataagcc ggcatcttga 1936921 atggtctgtg acgatctctt gcctttgaat aggtgaaaaa cagcgcttcc cgaccgttcc 1936981 ccgtttattt tgcaaagaca atcgagaacc ataatatcga agtaatttaa tgacaaccta 1937041 tccacctaca ttcttcctga caaaaatcgt tgatttgctc tttttatttt aacagatttc 1937101 aaacagaaat cgacgtttaa agtcatcatt aagggggatg ttatgtagat aaccccttat 1937161 gtgataagca ttctcaatca tttttctgtt gaaatgtggc agcaacatca ttacaataag 1937221 taagaggaat aggtgttaaa ttgattaaat ataaagattg atccatttgt tccaccaaga 1937281 acaatctggg aggttttatt catggcaaag tacacaatcg tagacaaaga tacatgtatt 1937341 gcatgcggcg cttgcggagc tgctgcacca gacatttacg attacgatga tgaaggcatc 1937401 gcgttcgtaa cgcttgatga aaacaaaggt gttgtcgaag ttcctgaggt actggaagaa 1937461 gatatgattg acgcatttga aggatgccct actgattcca tcaaagtggc ggatgagcca 1937521 tttgaaggcg acccgcttaa atttgaatag aagtaactaa aaaaagctcc cgaacgggag 1937581 cttttttatt taatggatat gtgcacttcg ctgctgctca atccatggct taagcttgat 1937641 aaaaattagt gagaatacaa ccgtaattac aatacctttt atcatgttaa acggcaggat 1937701 acctgcgacg actgctgttt ttagcgcgct gtcggataat gccggtgaat gtaaaaacca 1937761 cgtgtatgcc ggaagaatca gaacataatt taaaatactc attaaaatgg tcatcgctgc 1937821 agttcccaaa agcaggctga cagccaagcc ctttgctgag ttgagttttt taaataagaa 1937881 agcagtcggt aatataaaga gtgttcctgc aataaaattc gcaacttgcc ctacaggaac 1937941 tccggccatg cttccctgaa tgatatactg aagaacattt tttatcgctt ctacggcaat 1938001 acccgccaaa ggtccgtaaa tcagaatggc aataattgcg ggaacgtcgc taaaatcgat 1938061 ttttaaataa tccggaagac ccggaaacgg gaaatttaac agcatcaaaa caaatgcaat 1938121 gctgctcagc atgctgacca caactaattt ttttactttc acttcattct ctccttttcg 1938181 atcacatctt actcgaaaac ggaaaggttc ttttccagcc aataaaaaaa ccgcttcata 1938241 tataaaagcg gggtttcgaa aattaggcta ggcaaagaaa cgtttgaaaa attcaatttc 1938301 aaaacgctta tgaacctcca tcttctccca tccagactgt actgtcggct ccggaatctc 1938361 accgaatcct gctgtaaaga cagctcgcgg gcttagagcc attggctcat caccgccggt 1938421 agggaatttc accctgcccc gaagattgat catatgaaat ttaattacat tataaacgat 1938481 aactggttgg ctgtatagag aattgcttca aattaaatat attacctgca agctgtcaga 1938541 tcattgattt attaggcttt acttttatcc tttactgcgt caatacacgt tgacactctt 1938601 ttgagaatat gttaaattat cagatattta gtttgtcaat ttaggaggaa atctaacgat 1938661 gtttcgagta ttggtctcag acaaaatgag caacgacggt ttacagccac ttattgaatc 1938721 agactttatt gaaatcgttc aaaaaaacgt agcagatgca gaagatgaat tacatacttt 1938781 tgatgctctt ttggtgcgaa gcgcgacaaa agtaacagaa gaccttttca acaaaatgac 1938841 ttctttaaaa attgtcggaa gagccggtgt cggtgtcgat aatatcgata ttgatgaggc 1938901 tacgaaacac ggggtaatcg tgatcaatgc tccgaacggc aacaccattt cgacagctga 1938961 gcatacattt gcaatgatct cttctttaat gagacacatt ccgcaggcta atatctcagt 1939021 gaaatccaga gagtggaacc gcacagctta tgtcggttca gagctttatg gaaaaacgct 1939081 tggtattgta ggattaggcc gaatcggaag tgaaattgca cagcgtgcga gagcgttcgg 1939141 tatgactgtg cacgtttttg atcctttctt aacggaagaa agagcgaaaa aaatcggcgt 1939201 aaacagccgt acatttgaag aagtgcttga aagtgcggat atcattaccg ttcacacgcc 1939261 tttaacaaaa gaaacaaaag gcttattgaa taaagaaacg attgcaaaaa cgaaaaaagg 1939321 cgttcgctta attaactgtg cgcgaggcgg aattatcgat gaagcagcac ttctcgaagc 1939381 tttggaaaac gggcatgttg cgggagcagc gcttgacgtt ttcgaagtcg aaccgccagt 1939441 tgacaacaaa cttgttgatc atccattagt cattgccact cctcacttgg gagcatcaac 1939501 gaaagaagca cagctcaatg tcgccgccca agtgtcagaa gaagttctgc agttcgcaaa 1939561 aggcctgcct gtcatgtcag ctatcaacct gcctgccatg acaaaagatg aatttgctaa 1939621 aattaagcct taccatcaaa ttgcaggaaa aattggcagc cttgtatcac agtgcatgaa 1939681 agaaccagta caggatgttg ccattcaata tgaaggcaca attgctaaac ttgaaacatc 1939741 gttcattaca aaagcccttc tgtcaggctt tttaaaaccg cgcgtagact ctactgttaa 1939801 tgaggtcaat gccgggggtg tcgcaaaaga acgcggcatt agcttcagtg aaaaaatttc 1939861 ctcttctgaa tctggatacg ataactgcat cagcgtaaaa gtgacaggag accgcagcac 1939921 ctttactgta acggctacgt atattcctca tttcggagaa cgaattgtcg agatcaatgg 1939981 atttaatatt gatttttatc cgactggtca cttggtgtat atccagcatc aagatacaac 1940041 aggtgtcatc ggccgagtag gacgtattct cggagataat gatattaaca ttgcaactat 1940101 gcaggttggc cgtaaggaaa aaggcggaga agccatcatg atgctttcct ttgacagaca 1940161 tctggaagat aaaattgtga aagaactaac aaatgtccct gatattgtgt ctgtgaagct 1940221 cattgatctg ccataattaa aaaaactcaa gctatatagc ttgagttttt ttattgttct 1940281 atccccgtgt gtttttatgc aaaatatcta agacactcct tagctcagaa acaggaattt 1940341 ggcctggtgc ggacgcctct tctccagctc caaaagtaca agccgatcca aaaacctcac 1940401 cgctcagcct gctgatgagc cctgttgcag ccattgacat tgtaataatg gggcggtctg 1940461 catatattgt tttcattgta tacgtcgcat caagcagtgt taggagatct ccagtatcat 1940521 tcggcatgac agccattttt ggaatatgcg cgcctaagtc ctgcattttt cgaagtctgg 1940581 aaataatttc atcttttaca ggtgtttttt caaagtcgtg atttgacatc accacataga 1940641 cgttgttttc ttccgccagc gatactaacg cttttacatt tgcatctcct gaaaataatt 1940701 cgatgtctat cagatcgatg tcttttgttt ggattgccga ttccagcaaa gcaagatagg 1940761 agctttcgtc catctccatg ctcccgccct ctttgtgggt tctgaatgta aatagaaata 1940821 gcttgtcttc taaagattta cgaagcttag aaatgagctt tgtgaccgct tctctgtcat 1940881 tcgctttttc aaatacgtcg actctccatt caacaatgtc cggattcagt aattttactg 1940941 cctctgcttc attcagaatt tgtttttccg tctttcccat cagcggaatg atgattttcg 1941001 gcatcccttc cccgatggaa actcctttaa tcgttaacac gttcactcgt ctcaaatcct 1941061 ttcaatcttt accttgtttt attatacacg tacaactttt ttttgaaaat ttctattata 1941121 tgaatagcaa ctaaaaaaga gccttaaagg gctcttttta gtttaaggaa atcggatttg 1941181 gagcagctgg caccggaatt gcatctgata tgtcatattt gccgattttt ttcgttctgg 1941241 tttccgtaaa ggtcacttct gtgaagccaa actcttttgc agtcaaaagt agtccctcaa 1941301 tcattaaaat accggcaata gaatcatcaa cttctgactc ctttgaaaag cggatatata 1941361 agtgtttctg tttcttcgtt acagattgga cagcacccgc ttgaataaga ggtgtcgtat 1941421 cttcttggct gctcgattcc atttccttaa tcgcttcttt tactgtatca aaagaatgat 1941481 ttgacggaac gagaaagtct tgtccttgtt tattttggta caagtagtag gatcgttttg 1941541 actgtttggg aatcgaaatt tccgtaaaag tgccatatga gccaatccga accccagtct 1941601 cattttgatc cgataaaaat ttgacttttt cataaggact ccattttaag gattctttaa 1941661 gcaatttttt taacagtgta tcatctttta tagaaaatgc cgtagctggc tgatggactc 1941721 gtatacttaa ttccttctgc tttggttttt cctttatttc tacttcatct atgaaggttg 1941781 gaattgtaat ggcatgatca aggatgccca attcactact ttcaaacagc atatcctgga 1941841 tcgtttggtc tgcatttgtt ttttgaatgc tgacgggtat gattgcagat gtatcggcat 1941901 cagcaaccgc tacagtgatg taattgtctt gttccttttc aggaacgaca aacgatgtct 1941961 gatccaagga cgatgcagct tttgggctgt cttctgtctc agttttcgtt actgcgttct 1942021 cttgggacgc ttctttttgt tgaggctgtg cctgatcaaa gaaatgagga gaaataatga 1942081 aggcgatata aaccgcaatt gcagcggcac acgcggggcc aatccacctg acagcgggct 1942141 tatttttacg ctttgccatc gtcagccgct tgtaaatatc ctgaggcgaa cgatggtctt 1942201 taactgccgg aagttgactt aacaactcct ttatctgttc ttcgttccat tctgacttca 1942261 tcatccatta gctcctccct caaaagctcc atatgtttcc gaagtacttt gagccctctg 1942321 tgttgggtcg tttttacttt gctttccgag aagcgcagag ccttggctgt ttcctgtatt 1942381 gaatatccct gaataaaccg caagataatc acagctcttt gatcgattgt acattgatca 1942441 agcgcagcat aaatttcccg gacattttca tgttgaaccg caagttcgtc cggcagcaat 1942501 tgctgatccc tgacatcctg tgtatcccag tcaaatgtac cgagtatacg ctgtctgatt 1942561 gtttgctgtt tacggaacca gtctatcgca acatggcgtg cgatagacaa aagccatgtt 1942621 ttttcactgc ttcttccttc aaacgtatga taagaattta atacccggat ataaacctct 1942681 tgaagaaggt cttctgtctg gtttttatcc tttaccatat aaaataaaaa ttggtacaaa 1942741 tcttgatgat atgtatcata taataattga aaggtttctt ccatttgaaa cccctccgtt 1942801 cacttttttg tcgtatgaat agcttgaaaa gttacattac aactatatta cgagtaactg 1942861 gaatttggaa gggaatttat attaacatat ccttaaattt tattaatgtt ggctattaaa 1942921 aaaacacccg ctcagtcagc gggtgtttct tatggaacaa gattcttcgg caaattcaga 1942981 ctcgatttta ccgttttgtc ggaatataaa aagaaaatgt tgttccttta tctattcggc 1943041 tgtgcacagt aattgatccg ttgtgggctt ccacgatatt tttaacgata gccagcccta 1943101 acccggttcc tgctctgccc cttgtccgcg ctttatctgc cttataaaac cgctcaaaga 1943161 taaatggcag atcttcttcc ggtatgccag acccggagtc tttgatatca attttcaatc 1943221 catccttcac agaatggact gaaatggaga cactgccgcc ggctgaagta tgccgcagcg 1943281 cgttatcaat caaattggta aatacctgct ccatcttgtc ttcatcaaac ataaattcct 1943341 cttctgtgag agaaatgtca tgatctaaag caatattttt ttctttcgca acaccggaaa 1943401 acttccgaat gatcttttct aaaaactcat tcacattgat tttttcataa tgtaagcctg 1943461 tatggcctga ttccattcgg gctaaatcaa gcaaatcatt aactaaacgg cccattcgga 1943521 gcgattcgtc ataaatgatt tgggcaattt ctttccggtc ttcttcagag cttgcaatgt 1943581 catcgacaat tgcttcactg tatccctgaa gcatggagat cggtgttctc agctcatgac 1943641 tgacatttgc gataaagtcc tcccgcagct tatcaaggcg gcgttcttct gtcatgtcac 1943701 gcagtacggc aaccgctcct ctgacgtgcg attccgcata aagcggcgac atcaaaagca 1943761 cccatgatct gccttgaagc gtcatctcaa tcatttgttc tttttcagtg ctgacagcgt 1943821 tttgaaacag ctcttttgct tcaggcggaa gattgtcgcc ttctttgata ttcatgttct 1943881 gttcataata ccaagcctga agaaaacgtt cagccggcgg gttggtcaca agaatcgtac 1943941 cgtcaatatt aatggtaata accccgtcag ccatactgct caaaatgtta gaaagctgct 1944001 ctttttcttg attgagcgca ttgatatgaa agttaagctg ccggcccatt tgattaaaag 1944061 cggtcgccag ttcaccgatt tcatcctgag ttaaaatcgg gatttttgta tcgaacttgc 1944121 ccttcgccaa atcctgcgcg ccttctctca tttttcggag agggtacgtg accctgcttg 1944181 ataaaaagaa tgcgaaaaat gtggtcagca caatcgcaat tccagcggca agaaaaatat 1944241 agcgggtcgt atgttttgtt gtatctttaa cggcaagcaa agactgggat aaaaagacca 1944301 tgcctttctt tccgtctttt tcatacggga cacctacaat caggcgttca ttatccgtgt 1944361 ctgtatcgct cagtcccgtc cgtttgctta cttttttatg gtctttgaga gctttattta 1944421 agtctttgtc atgctgtatt tgctcaaccg taatagacga caggcgattt ttatcattcg 1944481 gagaatacca gtggttcttc tcatcctgga tgatggcaat gcttgttaag ttatcagcga 1944541 gttcccaagt gattgacctt gccagtgcct ggtcctcgtg attttctagg atgacagcaa 1944601 ctttattcgc aagctgtgtt aaatcattct cagcttcttc cacatggtag ttttcaataa 1944661 actccagcaa aagaaccgtt aaaatgaaca atacgatcaa gacgagtgaa aggatcgtaa 1944721 accacagctt gcctactacg cttttccaaa atttcattca gcgccgacct caaatttata 1944781 acctacaccc catacggtga caattttttt cgcagcttcc ggagatacct tgttcagctt 1944841 ctctctcaag cgtttgacgt gagtgtccac tgtccgtaaa tcaccaaaaa actcatattg 1944901 ccacacttct ttcagaagct tttcccgatc atacaccttg tcaggcgttt tcgctaagaa 1944961 atatagaagc tcatactctt ttggcgtcag gctcacttct gttccatcag ctgttacgcg 1945021 gtgagcatca tggtctattg acagatgtga aaacacgagc acatttttcg tcggtgtatt 1945081 ggcattgaaa taagaggttt gggatgctct tctcaaaagg gcctttacac gcagcacgac 1945141 ttctctcggg ctgaacggct taacaatata atcatctgtt cccgcttcaa acccctgcac 1945201 ccggtttgct tcttctcctt ttgcggtcag cataataatg ggtgtcgctt ttttttcacg 1945261 aatttgccgg cacacttcaa ttccatcagt ccccggcatc atcagatcaa gcaaaattaa 1945321 gtcataattg gcttcaagcc ctttggcaat ggcttcatca ccattttcag cttcatctat 1945381 agcataattt tcacgttcaa gatacattct taaaaggcgg cgaattctgg cttcgtcatc 1945441 aactactaat atttttgttt cgttcgtttg gtccatgttt tccccctgct ttccttctgt 1945501 tactttcatt ttatcaaatc gtgagaaagt ttgagaactg tgtcgctttc aaaggactat 1945561 gcataagaat gaagtccggc aagcacaaga tttacgaata ttaaattaaa cataataata 1945621 gcaaaaccga ttacggccag ccatgctgac ttctcaccgt gccagcctct tgacagtctt 1945681 aaatgcaagt aagcggcata gaacaaaaat gtgatcagcg cccatacttc cttagggtcc 1945741 cagccccaaa atctggtcca cgcgagctga gcccaaatca ttgcaaagat cagcgcgccg 1945801 agtgtaaaga tcggaaatcc gattgatacg gccctgtacc caacctcatc caccagatca 1945861 agattgacgt ttttcaccag cggatgtaat agagcgctga ttctttttct gatgatcaga 1945921 cggagagccc catacaacac aagacctgct ccaaatgacc aaatgacagt gttcactttt 1945981 ctgcctgaga aaagcgcggg aagatcaaca agcggttcca ttcttccttc ggtcaaaagc 1946041 tctccctgat gcggaccgac aagcgcgggc atttcgtaca ccatcacgct tttttcttta 1946101 cttttgtcca cccagttaaa ctccgcttca tagcctgcaa gacgaaatgc cgatgtgatt 1946161 gcaataaagg cgacggttgt gaccaggata aacataatcg cttcaagcca gaaggtcttt 1946221 ttgcttggct ttgtctggtc tacatgcttc aaaagaaaga tgacaccagc gacaaagctg 1946281 atggcaagta tagcttgccc aagcgcggcc gttgttacgt gaatatacag ccagttactt 1946341 tggagcgaag gaattaaagg cgagatatct gtcggaaaca tgctggcgta ggcaatcagc 1946401 aataaagcaa ttgacagcgt aaacaggcct aatgaaggca atctatagag aaaataaaga 1946461 atgataaacg ccaaaacaag catcatgcca aaagcggtgg tgaattcaaa catattgctg 1946521 acaggcgcat ggccgcttgc agcccacctt gtgatgaaat atcctaggtg gcagaaaaaa 1946581 ccgacaatag aaagggtgat tccaatgttg gcccatcggt ttggcctgcc ctttttatct 1946641 ttattcccgc gtatggcccc gccgaagatt gggacagcga ttaaatacac aagaaaggcc 1946701 gcataaagaa aatttccgct cagctctgcc atgacatcac tcccttttcg cctatttctg 1946761 tgttttgatt aattcttttt ggtccaccgg ttcagtcagt ccggaatcag ccaatataaa 1946821 tgctaaatcc ttcttcaggc caaaccagtt tttattggta tgccctgcta ccataactgc 1946881 accgtcctgt gagtgcagcc aaattcttcg atgctgccag tacatacctt gaatgacacc 1946941 gatcataaaa atggctccgc cgacagcaag cacccagagt gtcagatcct ttctgactgt 1947001 aagtccagta atgtttttcg tttcgacatg gtcaaatttc agcttgtatt tattattgcc 1947061 tgatccttcg atggtttctt ggatggcgac aaagctcttt tcgcctttcg gtttgtccgg 1947121 cgttatgata ttaaagacaa aagccggatt gttagggatc tttgtttttg tgctcggctc 1947181 tccgtcctga ttaaaataga agtcaggcag gtagctggcg atttccacct tgtaaccgtt 1947241 accaagatca tagactgaat ctggatccag aaggttgatc ttcaggctcc caaaggattt 1947301 ttttgttttt ttatcaatca gctggaacac catttggtca agctgattct ctttgtaatc 1947361 cacctggtaa acggaaaaag aatcaaaacg cagcggctga ttgacacgga tgtcttcttc 1947421 tgttactttt tccagcttcg gcttctcgcc ataaacaatt tttccttctc tcttgtagag 1947481 tacggcatca gtttgaaagt tctttgccac tctaccgtcc ccgactctgt caatggcatc 1947541 tgcaaatacc tttttttccg ttttgctgtt ataggtctct acgctgaatt gattgttttt 1947601 caaataatat tttccgtctg tacccggaat tgctgcggtt tcgccttctc tgacccaaag 1947661 cgtctcatcg acgtacatgc caggcacaaa tctcagcatc gcaccaatca gaaagatgat 1947721 caatccaatg tggttgacat acgggcccca gcgggaaaag cgtccttttt cagcaagaat 1947781 gctgccctct ttttctctga ttctataatg ttttttcttt aatagagtaa ctatcttttc 1947841 tttcgattcc ccgttcagta cagtaactgt ttcactgaac aagcgctgcc ttcttaaaaa 1947901 ggccgggctc cttctgacac cttggttttt taacgctcta tacaacggaa tgacccgatc 1947961 aaggctgcaa atcacgagtg aaatgccgat cgaggcaatg agcagcaaat accaccaaga 1948021 accatataaa tgatgaaacc cgagcaaata ataaagctgg ccaaacgtgc cgtactgctc 1948081 cttgtaataa gtatcagcct gtgcgcccgg aggcagatag gcttcctggg gaaaaatggt 1948141 gccgaacgct gatgcggcaa gggttatgac gataagccat attcccacct taaccgagga 1948201 aaagaaattc caaattttgt cgatgatcgt tttgttatag gtttgcgaac gtcttgcgct 1948261 tccgtcatat ctcatatcag cgagcggagg ttgagtttcc tgaagagctc ttccgcacga 1948321 ttcgcataaa acggttccga ccgggtttat atgtccgcat tcacatttga cttgcttcat 1948381 cccgaagtct ctccgggttt tatgagattc atataatcgt gtatcatgct ttctgtcata 1948441 gtgccggtca ccaccttgac aacttttcct tccggattga tcaaaaaggt tgtcggaagc 1948501 ggagatacgt cataggcatc aagcacttgg cgatctgtat ccagaacaac cgggaaattg 1948561 actccgtagg atttcataaa attatgtact gctatctttg actccccaac atttacagcg 1948621 acaatttcaa caccttggct tttaaaatgc ttatattggt ttgccatata aggaaactct 1948681 tttttgcacg gttcacacca tgtaccccag aaattcaaaa aaacaccttt cccttttaag 1948741 tcactgagct cgatacgttt cccattcgta tcctctagga caaaattcgg tgcgtcggac 1948801 ccttcggata tactctcttt gccggcaaat acagcgttgt aaatggtata gccgagtgcg 1948861 cagattaaaa cgagaaggat gccggtccga atgaataaac gccttttttt cttcattgtc 1948921 cactgccccc ttccccctat tgcagatcca ttcaattata tcattgcacg ttcatttcac 1948981 atttcttact ttttgaaggt tatgtgaaat ttagaaagcg tttttaccgt gatccgccag 1949041 tgctctgagc ctttttactt cgtgaggcgt aagctctctg gcatcgcccg tgtgcaggcc 1949101 tcgcaggttt aaaaacgcgt attcctcacg cttcagcttg attacctcat gtccgatcgc 1949161 ttcaaacatg cggcgcactt gtctgttgcg tccctcatgg atcgtcagct gaataatgct 1949221 tgtctgcttt ttcttatcca aagacagcag cttcgcttta gcaggcgctg ttttgccttc 1949281 ctccagccta attccgcgct ccagctttct gagcagctct ttaggcggga ttcctttcac 1949341 cttcgccacg tatgttttgt ctatttcata cttaggatgc attagcttat tggcgaattc 1949401 gccgtcattg gttaaaagca aaagaccgct cgtatcatag tccagacgcc caatcggata 1949461 aatgcgctgc ggaatatttt taaaaaagtc cgtcaccact ttgcgtcctt tatcatcttg 1949521 cgctgcggaa ataacgcctc ttggtttata taagagaaag taaaccggct cttcgcgttc 1949581 aacctttaac ccgtttacct caatctgatc agaaccggtg accttaacac ctagctctgt 1949641 tactactttg ccattcacct ttacttttcc ttctttaatc agctcttctg cctttctgcg 1949701 cgacgcaact ccggcatgag caatcacttt ttgcagtctt tccatgtctt tcacctcaag 1949761 tattatctta cttttttcaa ccttaacaaa caagcttttt caaattccta tgccaaatct 1949821 aaaaaaaacg ccgttttcag gcgctcccaa ataataacgt aacgatgatg atagatgcaa 1949881 ctacgccgat taaatctgca agaagtccca cctttaatgc atcacccatt tttttaatgc 1949941 cgactgctcc gaaatacaca gtcagtacgt aaagcgttgt atctgtagat ccctgcatga 1950001 cggaagccag cctgccgata aaggaatcgg gcccgtatac tgcaattaaa tcggtcgtca 1950061 ttccaagtgc ggccgtaccg gagatcgggc ggatcagagc aagcggcact acttcagcag 1950121 ggatgccgat agcggagaaa gccggtttta aaagatccat tataaaatca agcgcgcctg 1950181 atgatctgaa aacagttata gcgacaagca ttccgactaa ataggggata atggaaaagg 1950241 caatttctat cccctctttc ccgccttcga caaacgattc atatgtcgga acctttttga 1950301 tcgttccata aagaagaatt ccggcaataa tgattggaat catggctaaa gacagccagt 1950361 tgatgatttc catccgctca ccttcccttc tttttgcggc ggtaataaaa ataccgatca 1950421 atgataatgg caccgattcc ggaaataagc gttgccaaaa tgcttggccc gacgatatct 1950481 gtcggcgttt tggaggaata agccattcgg acagcgatca ccgttgtcgg gatgagtgtg 1950541 atgcaggacg tattaacagc taaaaaagta atcatcgacc ggcttgcttc cgatcggttt 1950601 ccgttcagct ttttcatttg ttccattgct ttaatgccaa gcggagttgc tgcatttccg 1950661 aggccgaaga aattcgccat aagattagat aaaatatagc ccatcgccgg gtgatccggc 1950721 ggtatatcag ggaacagttt agatataaaa ggtctgcaca tccggctgaa aatatccaaa 1950781 agccctgact gctcggcgat tttcattaag ccaagccaga aaacaagcac gctcatcaat 1950841 ccaaatgaga tcgtaatcgc ttctttcgca cccttaaaca cggcttcatt tacatcttgc 1950901 agagttccgt tgcacatcgc aaaaacgagt ccgatcacgg ttaaactgac ccaaattata 1950961 ttgaccattt tgctccgcct gccgcattca gaaagattga tttaaacgtt tcaaaaaatt 1951021 gtttcttcgg tttttgatgc cgctcatttt cataatagat cggcactttt gcgatggttg 1951081 catcgttgaa catgatctcc atgtgcccta cgatgtcagg gattttcgag gcatcttttt 1951141 cccatgcttt tttcggcttg agcagtgtgg tattaatttt tacattttct ttttcctctt 1951201 cggtcagcaa ataggtgata tcacgtttga taaaagcctt cgattcataa aatgtgcctt 1951261 tcagctttgg aatatcccct ttttttgcaa ttaaataggt ttgataatgc tcaaacacat 1951321 agttaaacat cttcatatgg tcatcccaat cattagggtc attaatggtg acggctatca 1951381 ggtcaatgcc gtcctttgaa gccgtagaga ccagtgtccg ttttgcaagt tttgtatagc 1951441 ctgtttttcc tcctgtgctg tacggataaa gcatggtcag cagtttgttt ttgtttttcc 1951501 atacgctttc catcgtttcc gctttgtata tttttgtgcc tgaaatcttt tgatagtctt 1951561 tcagcttcat agcatactta gttaaaatgg ccatgtcata ggctgttgaa taatgatttt 1951621 catggtcgtc caatccgtgc gggttttgaa aacgggtgtt tttcatacca agctgctcgg 1951681 ctttttgatt catcatataa acaaacccat cgaggctccc accgacatgc tcagcaatcg 1951741 cgacagcggc atcgtttcct gatcttagca tcaggccata cacaagatct ttcagcttca 1951801 ctttttgacc ttctgttaaa taaatggcgg agccttctgt tctgacagca tttgccgaaa 1951861 ccgtcactgt ttgatccatt ttgccggatt cgatggcgag gacggcggtc ataatttttg 1951921 tgatgctcgc gatccgcctt ttttgatgct catccttggc atataacact ctgcctgacg 1951981 caccgtcaat aatgatcgcg ctttttgcac tgacatctat agcagcatgt gctgtattca 1952041 catttacggt tgcaataaga aaagaaatca tgatcacgaa tactgctttt ttgaaaatgc 1952101 gcatgtttgc tcacgtcctt gtggtggttt gtacaagttt atgcgcatgt ccatcagtta 1952161 tgaataacaa ttatatttct ggaagcaaac ataaaaaaac tctccctgaa aaagggagag 1952221 taaacgttat ctgattggcg ccatgcttga tccggacgct tcgtaatgag ccagctcttc 1952281 cctcatcttc agaaaggccg cgctcaacgg caataataat tgctcaagcg acgcaggaac 1952341 agcatgataa aactcaattg cgctgacccc ggtataagac gcccggctat tttcacacca 1952401 cgtgtctttt ttcggcataa agaactcttc aatgcattgg tgatacacat tataaagtgt 1952461 tttttccgct ctggcttcct gaaaaggctc ctgcatcagg agacgacggc acgcttctgc 1952521 gcctccttca caaaatactg ccattcttct cagagtgcta agcacatcac agcagtatcc 1952581 tttttcaata ggcaattcag cctgtaagga ctcaagcgtc gtttgattta ggtaatcgtt 1952641 cacggtattg acaaccattg ataagaattc gcctgttttt tgagtctgcg ctcgcacaat 1952701 cgaatgtccc atttcgtttg gtatcttccc ctcatgtatt tgtctctcac attttgcttc 1952761 tttcatgata gcttcttcct tatatcttat gatgatgaaa aagcgcgatt cattaaactt 1952821 ctattttata tcttcgaagg tttggttaaa gttttcaaaa aataaatctg cttcttcttg 1952881 aagaacgtct tcttccgcat tttcaggcag cggcggaagc tcgtccagcg ttttcagacc 1952941 gaattgttca agaaaagtcg gcgtagtacc gtataaaatg gcccgccccg gaccatcggc 1953001 acgccctact tcacacaata gcgccttcgc gacaagactg tgtaaaatcc gctctgattt 1953061 tactcctctg atttcttcaa tttctgctct cgtaattggc tgtttgtatg aaacaatggc 1953121 cagtacttct aaagatgctt gagaaaggcc ctttgacggc acttcaatca gttttttcaa 1953181 gtaaggcgca aagtcttttt tggtagagag catgtacgta tctgcatact caataagttc 1953241 aatccctcgt gtatctccgc ggtattcgtc cgccacatcc gccatgatcg tgttcagttc 1953301 aggctcttcg atttcaagca ctgttaacag ctgctttttt gtaagccctt catcgcctgc 1953361 cgcataaaga agggcttcca caatagcttt ccaattcacg atatcaagcc ccatgaatgg 1953421 attcactccc cgtaatgtaa atatctgaaa aattgtgctc ctgttcaatg aggaccagct 1953481 gatttttcat cagctcaaga acagctagaa aggtcactac taaatgttct ttttgctcat 1953541 atggaaacag atccataaag ttaattctcg ttcctctaga tttcaagctg tgcacgattt 1953601 cgttcattct ggcttcgatt ggtatgtcct gtcttgtaat tgttgtttcc atcggcctgt 1953661 ttattttttt gcgtttcagc actttttgaa aagctccgat catatcatag accgtgacag 1953721 agagcttttg ctcagactgt tttacttctt ttgcatattc actcaaatca ctcggcggtt 1953781 tcgtgaacga tttttgtctt tcttcttccc gttcttttaa atccttcgcc gcatctttat 1953841 attttcggta ctcaatcagc ttttcaatca gttcctcccg cggatcttct tcttcaagta 1953901 attcatcttc aaaaagctcc tcctcttgct tcgggagcag cattctgctt ttaatgctga 1953961 gcagcgtggc agccataacc aaatactcgc tggcaatgtc gagctcaagc acgcgcatcg 1954021 tatgtacata taataaatat tgttcagtga tcttcgccac aggtatatca tatatgtcaa 1954081 tttcaagacg attgattaaa tgaagcagca ggtccaatgg gccctcaaac gtatcaattt 1954141 tcacttgata ttcttccatc atctcaccat tttcaagtat cactctcatt gccggaaaaa 1954201 ctggctaccc tatagtataa gccaccaaaa agctctcgtc caatactatt tcatatcctg 1954261 ttttgaagga gtttgtacag aatattcaaa acacaagagg tgtttgctcg gagcgcagaa 1954321 gcgggagaaa aagcctttgc ttctggtttt cctttctaag aagcactaga ggccgggcgt 1954381 tcttttttcc ttttatccct tctatggtac actaaaagca cattaaagga ggaagcacct 1954441 tgtatccgaa agcttatata gattatctcg ttgagtttca tgcgacacgg gattattttg 1954501 aatgccatga aatattagaa gaatattgga aggaagatcc gccaaagaaa cgaaaacgct 1954561 attgggtggg ctttattcag cttgcagtgg ctttatatca tcacagaagg cagaatacag 1954621 ccggggcaaa aagactgatg gcgaacagca tccggattct tcaagcagaa caccgggcag 1954681 tcgaagactt agggcttgat catggccgtt tgctcgaact tatgcaatcg gtttacgaac 1954741 aaatcgaaac cgtctctgcc tataaaagca ttatactgcc aatcaaagat gagaaactgg 1954801 aggaagcatg caggatcgaa tgcaggaaaa aaaagtatac atgggggcag cccagtgcac 1954861 tcagcaacat atttcttatc gacaaacacc gtttgcggga tcggactgac gtcatccgtg 1954921 aacgtgaaaa agaaatagaa cgcagaaaaa aaagcagaga ctgatcacag cctctgctta 1954981 attattgtat gaaatgtctt gatcctgctg accttgacaa cgttcgaaaa agctctgcgt 1955041 taattcattt ggaaccagta cttgcgtttt gaataaatgc tttaaagcat ccatcatctg 1955101 ttttccgatt ccttgatggc gatgagaagg attcacactg atatgccgga tctcaacctc 1955161 agaatccttt ttttcgactc cgattgctcc gacgatatcc tcgtcctctt tccaaagaaa 1955221 gagctggcgg tctgtatccg tttcgtagtc cttaattgtc tgctgaagct gcttaaggtc 1955281 tttttcattc ggcataaacg aaagaagccc catcgcaatc ttttcaaacg attttttata 1955341 acgaattaac ataaaaaccc ctctatatcc aaaatgtcca gtctgctatt aacggatacg 1955401 aataggtgat ccgttttctc acattatatc attttcgcca tatttttaaa ctgttttcag 1955461 caaattattc aaatgagcgg tttaaatttg ccatttcaat ggcagaaaca gcacaatcta 1955521 cacctttgtt gcccgctttt gtgccggcac gctcgatagc ctgttcgatg ttttcagttg 1955581 ttacaattcc aaagatgaca ggtacaccag tagtgtttgc tgcttgcgcg atgccttttg 1955641 cagcttcatt gcagacataa tcgtaatgtg tcgttgcgcc tctgatgaca gtgcccaatg 1955701 tgataatagc atcatatttt tttgtttccg ccattttttt cgcagcaaac ggtatttcaa 1955761 atgcgcctgg aacccaagcc acatcaatgt catttgtgtc tacgccatgt ctgagcagcg 1955821 catcttctgc tccgctcagc agcttgctcg taataaaatc attaaatctt cctactacga 1955881 ttccgatttt aagacctgta ccaactaaat ttccttgtat gatattcata tgattcccat 1955941 ccttttttgt gatatttgtg attagaaatg aagtaaatga cctagcttgt tcattttggt 1956001 ttgcaaatat tttttattgt gttctttcgc ctccatttga agcggcactc tttctgaaat 1956061 actgagtccg tagccttcaa ggcctgcgat ttttcgcgga ttattcgtca aaagcttcat 1956121 attccggaca ccgaggtcgc gtaaaatttg tgctccgatg ccatagttgc gaagatccgg 1956181 caagaatcca agcgcctcat tggcttctac ggtgtcatag ccttgttcct gaagcttata 1956241 agcttttaat ttattgatta aaccgatgcc tcgtccttct tggcgcaagt acaggagcac 1956301 tccacggcct tctgcggcaa tttggttcag cgcggcgtgc agctgcggtc cgcaatcaca 1956361 gcgatgagag ccaaacacgt cacctgtgag acattctgaa tgcacccgga ccaataccgg 1956421 ttcttctccg aacggcacat ctcccatcac aaatgcgaca tgctcttttc catctacctc 1956481 atttgtgtat ccataaacct taaatgtccc aaaatcagta ggcagcgtaa tgtcaacttc 1956541 acgctcgaca agtgttgtca gattgtaacg gtattgaatc aaatccttaa tggtgatcat 1956601 ttttaattga tgctttttcg caatttcaat gagctcaggc actctcgcca tcgttccgtc 1956661 ttcattcata atttcacaaa tgacgccggc tcctggagat ccgcaagctt cagcaagatc 1956721 aacagcagct tctgtatggc ccgctctttt caggacacct ccttttttcg caatcagtgg 1956781 aaaaatgtgc cccggacgct gaaaatcaga tggcacggat ttgctgtcca gcaatgcttg 1956841 aacggtaaaa gatctttctt gagcgctgat acctgtcttc gtttcacgat ggtctatgct 1956901 tacggtaaat gcagtgtggt gagagtctgt attatgctca accatagggt gaagatcaag 1956961 cctgtctgcg atttcctcac tgagcggcgt gcagatcagt cctctcccat gtgtcgccat 1957021 aaagttaatg acttccggcg ttgcatgctc ggcaagagcc acaaagtctc cttcattttc 1957081 tctgtcttca tcatctacaa cgatgatgac ttcgcctttt tttaaagcgt ccagtgcttc 1957141 ttctatcgga tgaaacatgc aaatcttcct ctctaaaagc cgttttcgct taagaaggct 1957201 tttgtaatgg tttgttgggt cttattttca ttggctttat gcaaaaatcg atacatatat 1957261 tttccgatca tatcgcattc gatattcact ttagagccga tcgttttttc tgaaaagatc 1957321 gtttcgctga tcgtatgcgg tattaaggag atcgtcactg tgtcttctgt caggccgaat 1957381 atggttaagc tcacgccatc cacagtaatt gatcccttta aaaccaatgt ttttgttaat 1957441 gacgggtcca tttttaaatc atagtaaact gcgttgcttt tctcttcaat tcgtgtgatt 1957501 tccgcagttc cgtcgacatg gcctgagacg aaatggcctc cgaaacggcc gtttgccgcc 1957561 atcgctcttt ccagatttac tttgcttcct tttgttaaat cattcagtga cgtagctttg 1957621 actgtttcag gcataacatc cactgtgaat tgattttttg taaaatcagt gacagtcaga 1957681 caaatgccgt tcactgcaat gctgtcgcca agatgaacat cctctaaaat ctttgagcat 1957741 ttaatagtta aggccattgc atgccctgct tttttcatgg attcgattgt gcctgtttct 1957801 tcgataattc ctgtaaacat ggtcaccatc ctattccttt gtcggttttg ccgtcagttt 1957861 gatatcacgg ccgatttggg ttatatcagt gaattgtaat aaggggacat ctttcattga 1957921 ttgaaaacct tcaccggaga ttaagctggg agcatgcgtt cctccgatta gtttaggggc 1957981 aaaatagaag atgatttctt gaaaacagcc ttctttgaca aagcttccgt gaacagctga 1958041 accgccttcc acatacaccg acatgatgcc ttcttccgct aggatcttca aaacatcagg 1958101 aatttgaatg cgctcggttt caagtgtaaa tatgttcact ccgaaagctg aaagccgttt 1958161 tttcttttcc tcgtctgcgc gtgccgtcgt aaaaatccat gtcggcgcta tttgatcgca 1958221 aatcacttta gcgtcctcag gaatcgagag tacggtatca agtatgaccc gaaccggctg 1958281 ttttgttaca ttcggcagtc tgcaggttaa gctcggattg tcggctttca ctgtgccaac 1958341 tccgactaaa atgctttggt gtgttttcct gtattgctga gcatcctgtc ttgcagcctc 1958401 tgacgtgatc catttgctgt cacccgtgct ggtagctatc ttgccgtcaa ggctggcagc 1958461 cgcttttagc gtgacgtacg gaaggcctgt cctcataaag tgcagaaatt tttcattcag 1958521 cctctccgcc tggtctgcca ggatgccttc ccttacctca atgccagctt ctttcatcat 1958581 gctgatccct cttccagcca caagcggatt aggatctctc atcgccacga acactctttt 1958641 gataccagag ttgataatca attctgcaca tggcggtgtt tttccgtaat ggctgcacgg 1958701 ttcgagtgta acgtaaatgt cggcaccctc tgcatgtgct ccagccatat ggatggcatg 1958761 aacttctgca tgagcttcac catattttaa atgggcgccc attccgacaa tttgtccgtc 1958821 ctttacgaca acagcgccga cgagcggatt ggattcggtc tgtccttcgc cctgcttcgc 1958881 aagatctaag gccagcttca tataatactc ttccatttgt ttccctcccc tcttttgtta 1958941 tttaccgtca aaaaagcccc gaatttataa aaaattcggg gctttaggta ttttacgcaa 1959001 taggaaataa cactatgcat ttttaaacat tttgcatagc ggctcatcat ccttctccca 1959061 tccagacttt cactgtcggc ttcagcttaa actgaatcca ccgcgtgctt atgcacacgg 1959121 gtcacgggct ctaaagcaaa tgtgctttac taccgccggt cgggatttcc accctgcccc 1959181 gaaggataca atctttattc atttgtcctt attggttatt atagcgatcc tttttaaagt 1959241 acgcaatgaa ataaacttac aatttgagaa aaacaaaaca tcacccttcg atccgaaagg 1959301 tgatgttttt taatcattca cttttgcaac cttgattaat ccgtcgatcc gctttgattt 1959361 gctgaagtaa gccttaatct tgtcaccttc ttttatatca gataaatcct gatttaattt 1959421 ttttccgttg aagatgattt tcgttccgtt ttctgctact ccatgatact ctgagccgtc 1959481 aattttcgtc actttatatt cctggatggt gtattcctct tcttccgagg acaaggtttg 1959541 tccaattgct gtcggaacat ccttcagctc aatatcattt atgtacatat aaccgcctgc 1959601 aagtaaaagc aaaagcacta acagaatggt aatcttggtt tttattcttc ccatttctaa 1959661 acctccagcc aatatgaatc tattcattca tatgagttat tccttttttt catgaataaa 1959721 aaaccgtaaa ttctcgtaaa ttattaatat aacgatgcat aacgggaata tgtttcacat 1959781 ttctgcaaaa atttcttttc tatagatata cgaatttatg ttctgttttt aggggatgac 1959841 cgtaaaaaag atataaaaaa agcagcccca atgggaagct gcttgatcct aatttgtttt 1959901 gcgcatttcg ttaaacgggt agaaaacaaa ctttgacgta cccgcaattt gttttttcgt 1959961 gaagaggcca aggccgttac ggctgtccat ggaattgcga cgattgtcac ccatcacaaa 1960021 atacttgtta tcaggcactt taaccgggcc gaaatcatcg gtcaaatggt caaaaccgtc 1960081 ctgtttcgct ctctttttat tagccgccaa ataaggttcg tccacctttt tcccgttgat 1960141 atagagctgg tcatttttca tctcaaccgt atcgccggga aggccgataa tacgtttgac 1960201 atagtgaaca tcatctccgt ttaacacgac gatgtctcct ctatcaaact cgccgatgta 1960261 tttgactgtc atattaacaa aaaccctttc acggttgtga agtgtaggat acatagagtc 1960321 accatcaacg acatacggcg caaaaataaa gttgcggatg agcaaagcaa gaacgacagc 1960381 aatcacaatt gcttttgccc attctaatat tgactttttc ttcgaaacat tttctgattt 1960441 caactgattt cctccaataa acaacggtct tcaatttatg ttatcacgaa tcgaaaaaaa 1960501 atcccattag gaccattgaa gtgattttac aaactgttaa tcttcatctt ctacccacat 1960561 catgcctatt ttttcttgtc gatcataact aggcctgaaa atattgaaag aaatgaatcg 1960621 cataattcag aagcgatgga ctcagaagaa agagagttct catatgcaaa atctttagat 1960681 cgtatataaa gcatgaggtt acgggcagtt tgttcattta ctgcattcca ttgatctccc 1960741 agtccatgat acccatggca cttgacaaaa caattaacgt catgaaggtt actggaatgt 1960801 ttgcggcaac ctatttcaca ggtgataacc gcaccccgtt ttttgctttc ataatatgtt 1960861 taaaatcatt caagctcgaa aacatggatc agcctccaaa aaataaatcc aatatattcc 1960921 cggcagttga agactcttta ttataaaact ctgaatatcc gcagttctta cagtaaacca 1960981 ctagaaatcg gttatgctgc acgtcaaaca gctttgataa tcccgtgccg gttgtagcta 1961041 tttctttttg tccggcttca gtactaccgc attttataca gcctttgttg ttcatatcgc 1961101 gatctccttt tcattacatc acgtttgttt gatttatttt actacaaaat atcaatccca 1961161 atgacccgta ctactttaaa gtttacttaa ttttgattac atactaattg ggttcgtttc 1961221 tcagcttggt aaatcttctg gagaaacgga aaagctccat gaccaaaaca ttcaaactca 1961281 gccaaacacc gccgaaggcg taacccgcag caacatcact cggatactgc tcataaagta 1961341 cacacggctc agcccgatga ggaataaaac gataataaac aaaaaaatgc aacagtttgc 1961401 agacgcgtct tgtgagaatg acgaacaaaa agataagcac aaaaaccaaa aatgacaaat 1961461 gccgttaaag tctgttcgct cgggaatgga tataatacat gactttccaa aggagcgtga 1961521 acaggatgaa gggaatgaaa gagccgtctg attccctctt cataaagctc cccaccaatg 1961581 actaggaaaa ataagaaaga gagttcgatt ttccgatctt gccctctgaa taccgtccaa 1961641 aaaaaagtta gaacaataac ggctaacaga acacctctcg acgcaaaagc tttctgaatt 1961701 gcagctgggc ccagtctata cccgatccaa tacgacatgc tcactcccac agctccccaa 1961761 tccggccgct aacatgctta gcacccagtt taacttttct tgaaacacga gaacaccggc 1961821 aaactctccc ggtccaagta aagctagaag ctctaacatc aagacaataa acaagacggc 1961881 atatccgtac tgttcgagca accccgtcaa aacttgcatg tgattctcct taaacttttt 1961941 tgttctttta tcattcccaa tccacttttt gtataatcag cacaatttta tcttcagtcg 1962001 tccaacaaca ttgtctatgg cgggatcttc tctcatacat tcttttttga cataggagga 1962061 gcaatagcat gaaatgggag gaaacaaaag atacgcaggg agtttgccaa aattttgggc 1962121 agttcgttct gccaccgagt caggtgtttg tttgcccacc tcatcccttg tcaattcccc 1962181 atttttcccg tttgaggttc gaaatggtaa agtatttcac ttagtttctt acatgaagag 1962241 gtaaattctt tgctcaccga actaggatag cggcgtatgg cgatttctac attgcataac 1962301 cactggttat ttagtgagcc gtgagcaatg tatatgcact ttgagtcagc acaggatgat 1962361 cctattacat tcgccagaaa agcagctgcc gcattcagag tagttaaaag aatagacaga 1962421 tatctgggct tccggaagct ttaaaggagg ctcttttttc gagcattttt ataaatcaat 1962481 aaaaacaggc atctcctaaa tatttttgcc gataagttta cgctaatcaa ctctagcact 1962541 aatacatata aaaaatagaa tgatatgaaa ggagacttga tagtatgatt gattatccta 1962601 ttaatataaa caacgtttcc gggaacagtg taattaacgt aggcggcgct tttatgatca 1962661 ggcctttaac tttgtccaaa tctgtgtttg gctccggagg tttaaacaca ggaattgtct 1962721 ttgaaaataa ctttgtaagc aaagctaaaa tgattaatca tcaatttact gatcaaaacg 1962781 tcaccaaaac tttttaatgt attcaataca cgggggtcac taactaaaca cctggttttg 1962841 ccaaccgcca tcagcattcg gcggtttttt attgaacatt tttggccaat aaaaaaagct 1962901 tcctctctaa gaggaagcct tttgcctgcc gattagcctt ctacacgaac ttctttcatg 1962961 acatcgccat tagacatgtt tttcgcgaat tctaatccgc ttgttacttt accaaataca 1963021 gtgtgaacac cgttcaaatg aggctgtggc tcatgaacga tgaaaaattg gctgccgcca 1963081 gtgtcttttc cggcatgtgc catagaaagt gcgcccgcct catgtgtatg cgggttgcct 1963141 tctgtttcac atttgattgt gtatcccgga ccgcctgtac cagttccgtg cgggcatccg 1963201 ccttggctga cgaagccagg gatcactcgg tggaatgtaa gcccgtcata aaagccttcg 1963261 ttcgcaagct tttcaaagtt tgcaacagtt ccaggtgcag cttcaggata aagttcaaat 1963321 tcaattttgt tcccgtcttc taataaaaag taacctgttt tcaattgtat gcctactttc 1963381 tttattttaa ttttcaaagg agattatgta taggttatag cctgtctctc cttgtcgcgg 1963441 ctattatacc acacctttcg ggggaaaacg aatctcccga gctttactaa aaaataaaaa 1963501 tgaaacctga atctctttat ctccgtctaa cctaacggaa ctgtattttt catgattcag 1963561 gtcctcacaa agcagcacta tccagctgct tgtgaaattg aaggaggtca aactgctttg 1963621 aagaaaattt ggattggaat gctggcagcg gccgttttgc tgctgatggt tccgaaggtc 1963681 agtctcgcgg atgccgcagt tggagatgtc attgtaacac tgggtgctga tttgtcagaa 1963741 tctgacaaac aaaaagtgct tgatgaaatg aatgtccctg ataatgccac aacggtaacc 1963801 gtgaccaata aggaagaaca tgaatattta ggaaaatata tatcgaacgc gcaaatcgga 1963861 tcgagagcga tttcttcatc gtcaatcacc attgccaaaa aaggctccgg attgaatgtt 1963921 gagacccata atatcagcgg catcacagat gaaatgtacc tgaatgcact gatgacagcc 1963981 ggtgttaaag atgcgaaggt gtatgttaca gcaccgtttg aagtatccgg gactgccgct 1964041 ttaactggat tgattaaggc gtatgaagtt tcttctgacg aagcgatctc ggaggatgtt 1964101 aagcaggtcg ccaaccaaga gcttgtcacg acatcagagc ttggagacaa aatcggtaac 1964161 gaaaatgcgg cagccctgat tgcaaaaatc aaagaagagt ttgctaaaaa cggggtgcct 1964221 gataataaag ctgacatcga aaaacaagtg gatgacgcag cttctgattt aaacgtcaca 1964281 cttacagaca gccaaaagaa tcagcttgtc tccctattca ataagatgaa aaacgctgac 1964341 attgactggg gacaggtcag tgaccagcta gataaagcga aagataagat tacgaaattc 1964401 atagaatcag atgaaggcaa aaacttcatc cagaaagtca ttgatttctt cgtatctatc 1964461 tggaatgcga ttgtatctat attcaaataa gaaaagcgcc gaaaaatcgg cgctttcttt 1964521 tattgcttta cacccgtttt aaatggcaga tcaagtttta caatatcttc gtatgtttct 1964581 cgcttcacga ctaaatgagc ctcaccgttt tcgacaaata caacggcggg tctcggaata 1964641 cggttataat tgttggccat gctgtatcca taagcgcctg tacaaaaaac ggcaagaaga 1964701 tcgccttctt ttacttccgg caggtcaata tcccaaatca gcatatctcc gctttcacag 1964761 cactttccgg caattgatac cgttttgtca tgcgcttctc cgatcctgtt ggctgccgca 1964821 gcttcatatt tagcttggta aagcgcagga cgaatattgt cgttcatgcc tccgtctaca 1964881 gccacatatt ggcggacacc cggcacttct ttttgagagc caaccgtata aagagttgtg 1964941 cctgcgtctc ccacgagaga acggcccggt tcgatccaaa tttccggaat gtcaaaaccg 1965001 taacgggaag cattttcttt cacagcttcg ataatttttt caacgtattc agtggcatga 1965061 agcggttcat catcttccgt ataacgaatg ccgaaacctc ctccaagatt cagcaccttg 1965121 gatacaaatg aatatgaatc tctccattcg tctagttttt tgaagatttt ttccgctgct 1965181 aacacaaaac cggccgtatc aaagatttgc gagccgatat ggcaatggac acccagcagc 1965241 tgaatgtgtt ccgattgtaa tacttgttca atggcccgtt cagtttgtcc gttatgaaga 1965301 tcgaaaccaa actttgaatc ttcctggccc gttgtaatgt agtcatgcgt atgcgcttct 1965361 actccgggcg tgatccgaag aagaacatcg atggagtgac ccgtttcttt acataggtct 1965421 tcaagaagcg cgatttcata gaaattatcc accacaatgc agccgatgcg gtgctcaagc 1965481 gccatccgca gttcttccct gctcttattg tttccatgaa agtggatgcg ttctgccgga 1965541 aagcctgctg caacagccgt atatagctct cctccggata cgacatctaa agaaagtccc 1965601 tcttcctcag cgagctgaat cattgcgact gatgagaatg ctttgctcgc atatgccacc 1965661 tgtgctttca gccctgcaga aataaacgcc tgcttaaagc ttttagcacg ctcacgtatt 1965721 aaagccacat catatacgta aagaggtgta ccatatttct ccgctaaata gagagcatcc 1965781 acacctccga tttctaaatg accatgttga ttttgtctgc ttgtgccgtg taagaacaat 1965841 gtcattccct ctttctccgc ttatggatga aaggacagtt ttatggactg tcccttcata 1965901 attaagacat acattatcat actcttcagt cagtttcaat gcgattatga attggtaggc 1965961 tgccttaagc gatttttggg gtgaacgatg ctgggtctta cttttgcgcc aggtttcgct 1966021 gtgcggacaa gaacctgcca cagcgccttt ccgttaaagg gaatcagcgg ccataagtac 1966081 ggtgtctgaa gggatttgat gcttgccatg gcaataatta gcactgtaaa tccgatgacg 1966141 agccctttta tatgaaataa agcaacgagt atcatgagga caagacggct cattttgttt 1966201 gccaagctta attcataact aggcgtcgta aaggttccaa tcgccgcaag tgagacgtac 1966261 agaatcacct caggagaaaa aaggccgacc tcaatcgcaa tctgcccgat cagaacagcg 1966321 gcaattaaac ccattgctgt cgataaagcc gtcggtgtgt gaatggcagc cattctgaga 1966381 aactcgattc ctaagtcagc taaaaatatc tgcaggatga tcgggatatg cgtatcttta 1966441 tttaaaccga taaatttcat gttgtccggg agcagatcag gctgaagcac aaagagaaac 1966501 cagatcggaa gaaataaagt agaagcaaga ataccgaaaa atcttacccg agctcgtggt 1966561 cattcggcat aattacttaa attttgtcca gtctcccatc gtccgcttta agaatgtgat 1966621 aaacccggct ttcttcatat cttcttttgc agcaacagga ctttcagcga gtacttctcc 1966681 atcctttttc agaacaagag tgccaagctc ttggcctttt tgaatcggag cactaatatt 1966741 gtccttcatc ttgatttctt ttttcacatc gttcatatcc tcgccttttt tcgtcaatat 1966801 tgaaatcggc tcagatgtag tgagttcgat aaatttttgt ttcccttttt tgacctttac 1966861 ttttgctact gtttgatttc gtttatataa aggatgcgtt tcatattggc taaaggcgaa 1966921 gtcaagcatt tttgtcactt gcgcgtttct ttctttaggc gtgctcgctc cgaatacaac 1966981 cgctatggcc cgcatgtttc cttttttagc cgaagcagtc agacaatatt tcgcttcgcc 1967041 tgtatagcct gtttttacgc cgtctacacc aggataaaat ttgataaggc gatttgtatt 1967101 tacaagccaa aactttttat ctgtattttc acgcagataa tcttcatacg tgccggtaaa 1967161 cttcgtaatt gattcgtatt tcaataattc cttagccatg attgccatgt cataagcaga 1967221 gctgtagtgt ccttcctcgg tcagtcctgt tgggttttta aaggatgtat ttttcaatcc 1967281 cagctctttt gcttttttat tcattttctt cacaaattct tcttcagagc cggaaataaa 1967341 ttcagccatg gcgacggaag cgtcatttcc cgaagcgatt gcgatgcctt tcagcatttc 1967401 tttgacagtc atttcttcgc cgggctcaag gaatatctgt gagccgccca ttgacgccgc 1967461 atgctcgctt gtacggacct tatcactcat tttgattttg cctttatcta aagcttccat 1967521 aatcaaaagc atcgtcataa ttttcgtcat gcttgcaggc gccagtctct cattgctgtt 1967581 cttgttgtaa agcacttttc ccgtgtcacg ttctatcagc accgcagact tcgcttcatg 1967641 agcaagctcc gatgtacgtt ttccgtcttg ttttgcaaat gcagacggtg caaatgtaag 1967701 cagcattata ccaatcaaca aagtggataa aagacgtttc atctcaaaag ccctccattt 1967761 cataatcctt tttatttttt ccaagcgtga tggttttata cgccactgat ggaaaatgtt 1967821 tcgaattttg ggcataaaaa aagacagctg tgtgatatca gacacagctg tcttttggtc 1967881 ctgcattgat tcatatttat tcgtactgag cgacgatcgc tttaacaagc tttaagaatc 1967941 cagcttttac tttttcggtc acttccataa cttcatcgtg acttaaaggc tgatccagaa 1968001 ttccggctgc cgcgttagag atgcaggaaa tgccaagaac ccgcattccc gcatgattcg 1968061 ctacaatgac ttccggaaca gtagacatgc cgactgcatc agagcccatc gttcttaaga 1968121 aacggacttc tgccggtgtt tcgtaagaag gtcctgtcac agcagtgtac acgccttttt 1968181 gaattgggat attaaggtct ttcgcaatct tttcagccag gctggacaga tctttgtcat 1968241 aggctgaaga catatctgga aatctggcgc cgaaatctgc ttcgtttggc ccgattaacg 1968301 ggtttgttcc cataaagttg atatgatcgg taataatcat taaatctccc gcacggaatt 1968361 cagtgttgac accgcctgcg gcatttgtca cgatcaacgc ttccacaccg agcgctttca 1968421 tcacgcgtac agggaatgtg actttctcca ttgagtagcc ttcataaaaa tgaaagcggc 1968481 cctgcattgc aatgacggaa actccttcaa gagtgccaag cacaagctgt ccggcatgcc 1968541 cttcaacagt agataccggg aattcaggta tatcttcata tttcagcttg accggatttt 1968601 cgatttcgtc cgccaaaatg ccaagacctg agcctaaaat aaggccgatc tttggagatt 1968661 ccggcaggtt ttgtttaata aaagcggctg cgcgttcaat tctgtccttc aagaaacagt 1968721 ccccctattg taataaagat aaaaagcttt tcccgtattt cggtttattt gtttggaaat 1968781 tatcagcgat cgttgcgcca atatcggcaa atgtatctgc aagcggcagc atttgcgctt 1968841 tcttatgttt tttgctgtaa gcgagaatcg gcacatactc gcgtgtatgg tcagtcccat 1968901 gatgaatcgg atcattgccg tggtcggctg taataattaa cagatcgtct tctctcattt 1968961 tttcaaacac ttccggaagc cgcgcatcaa attcttcaag cgcgcgtccg tagccttcag 1969021 ggtcacggcg gtgtccgaat aacgcgtcaa aatcaacaag gttcgcaaag ctcagacccg 1969081 taaaatcttc tcccagcgta tcgatcacct tgtccattcc gtccatatta gaaaccgttc 1969141 tgcgtgaaga agtaatgcct tctccgtcgt aaatatcaga gattttaccg attgaaatca 1969201 catctaagcc gcagtctttc aattcattca tgacagtgcg gtcaaacggc ttcagcgcat 1969261 aatcatggcg gtttggcgtc cgtttgaatt gacccggctc tccgacgaac ggccgtgcaa 1969321 taatgcggcc aaccatatat ttcggatcaa gcgtcagctc tctcgccgtt tcgcaaatgc 1969381 gatacagctc ctcaagcggc acaacctctt cgtgagcggc aatttgcaga acagagtcag 1969441 cagacgtgta aacaattaaa gcccctgtct ccatgtgctc ctggccaagc tcatccaaaa 1969501 tcgctgtgcc ggaagccggc ttgtttccaa taattttgcg gccagatctc ttttccagct 1969561 cttgaagcaa ttcatcagga aagccttccg ggaacacttt aaacggttta tcaatgtata 1969621 aacccataat ctcccaatgg ccggtcatcg tatctttgcc gtttgacgct tcttgcattt 1969681 ttccataata ggcaagcgga tgttctgttt tttctacacc tttgatatct tcgataagac 1969741 caaggccgag ctttgccata ttcggcatat gtaatccgtt catatgctcg gcaatatgac 1969801 cgagcgtatg agcgccttcg tcattaaagt cagcggcatc cggcgcttcg ccgattccga 1969861 ctgagtccat cacaattaaa aacacacgat tatatttgta tgcaggcatc ttgaaagcct 1969921 cctttttttc tatacgtcta ttgtatcgct aagaggtctg acaactcaag tataaaccgt 1969981 tttcattccc gttgacaatg tatttggaaa taatgagaaa cttcaatatt ttctgtcgct 1970041 ctaaacaaaa aagccgcagc cacctgcggc tatgctcgcg gatgaaactg cttgtacaca 1970101 tccttcagcc ttgttttcgt cacatgcgta taaatttgcg tcgtggatat atccgcatga 1970161 ccgagcattt cctgcaccgc tcttaaatct gccccgttct caagcagatg cgtcgcaaag 1970221 gaatgcctga gtgtatgcgg agtcagctct ttcttaatgc cggcttccaa tgcgattttt 1970281 ttcaggttct tccaaaatcc ctggcggctg atctgtttgc cgtgatgatt taaaaagagg 1970341 gcgtcagata cattattttt taacagtttt cccctggctt ttgtcatata ttcctcaatg 1970401 gcggaagcag cggcttcacc gattggcaca atccgttctt ttcttccttt gccgaagcat 1970461 cggataaacc ccatagataa atgaacatca gccgttttca attcaatcat ttcactgact 1970521 cgtatgcctg tcgcataaag cagctccagc attgctttat cccgatatcc gaaagggctc 1970581 gtcagcttag gcgtgtccaa taaccgctcg acttcattga gcgcgagcac cttcggaagc 1970641 gcccgttccg tcttttgtgt ttcgatatga acggaagggt ccttatccgt tactttttcc 1970701 ctgagcagaa attgatgaaa agagcgaatg gatgccaaat gccgcgccga tgtcttgccg 1970761 gatttccccg agtccttcaa atgctttaag tattggataa tatgtatgcg ggtaacgtga 1970821 ttccaatctg taacatgaag ggtttctgtt aagtagagag aatagctttt caagtcacgt 1970881 tcataggata cgatcgtatt ttgagagagc cctctctcta ccataacgta gtggatgaaa 1970941 tcctttattt gatctttcac tcttgatcta ctccccgttt tggtaaaaaa agatcaaccg 1971001 gtcgaaccat ccgccttttt catcctgatc catttcaaca acttttacag cggagccttc 1971061 cggtttatca taccgatgat agttttcata ctcttgattc acccatatca tagcataata 1971121 gaacaaagcg gtaaaaccgg taaacaggat gaaaactttc aatgcatcga cagctgtttt 1971181 caggaatctt cccatgtcct aatcgatcct ttccctatgg ttccagttat ataaaccata 1971241 tgccaaatca gaaaggtttt atacatagaa acagcaaaaa accctttccc catgagaaaa 1971301 ggttcgcgct cggcaccgtc tattcagttt cttttccgtt acagcggtgg caaatgccgt 1971361 gaaacgtcaa tctatgatct ttaatcttaa atttccaatc acgttcaatg atttcttcca 1971421 cgtcttcaag caaatcttct tcaatttcat caacggctcc gcactccatg cacaccaagt 1971481 ggtgatgaaa gtgagctgcg ccctctttcc gaaggtcgta acgggacaca ccgtctccaa 1971541 agttaatttt atctacgact tttaattcag ttaataattc aagcgtacgg tatactgtag 1971601 cgagaccgat ctcaggagat ttctctttta cgaggaggta tacatcttct gcgcttaaat 1971661 ggtcttcttc gttttcaagc agcactctta ctgtcgcttc acgctgtggc gtaagtttat 1971721 agctggatga gtgcagttgt ttcttaatac gatcaatacg gttttccatg tctttccctc 1971781 ctacgccgca ttccatgact cattataaca aaatacgcgc agagttccaa ctataattat 1971841 tataaactga taaataaaat ggttttcttt taataatgat tttaaaaaag tctagatgta 1971901 agcttttcca ttaaaacagg agataagtat gcttcaaaga gagatgaaat cagcgctaaa 1971961 aacagaatga ccagcagcac aaaggcatac cgcccgaacc attgaatcgg cgcgtcatgc 1972021 aggcttcgtt tcacgaacag ctgtctgatt aactttaaag aaaacgcaat tgcacatgtg 1972081 cccataatga gataagccgg aatcagcagc acattttgcg gcaaaacgga gacaaatgat 1972141 aggaaaaacc cgcttactcc catctgattg actaggaacc cgacagtaaa gccgacgacg 1972201 atccctttca gaaagatcat aatgaaaata atcggcatcc caatgacgga aattcccagt 1972261 atccacatca ggcctaaata ctttgcatta tgaaagatac tttgcccaaa catatcagct 1972321 gaacttgcct gttttccatc cgaaagctgt ccaaaaaatt gacttaagta gtagtataaa 1972381 tcttctttct ggctgatggt catactgttg acaataatcg cgccaaagat gacacccatg 1972441 aaaaacagca ctgacacaaa tatataaaga gagagatgat ctttgacatg cctgagaaac 1972501 atgtccttat aagagatttt tcgcataccg tttcctcccg cccgctctag tgatttgatt 1972561 taatagattg tatgaaagaa acagaaaaac atgccctttt tcaaaaagaa acaatagaga 1972621 tgaatgctag gcggcttttt ggggcacaaa aaaatcctta tcatcaactg ctgtatgatc 1972681 ataaggattc ttatgcttcc gtttattcaa aatctctttt ttgctttttg tcattcttcc 1972741 atgtgtgctg aaagatggtg tgctgcctct tgataataag acgtcacgtc cgccgtttct 1972801 caatcgatgc ccccgcttct ttttcgcttg gctttttgcc atgtgatcac tccctttttt 1972861 attttcatag taatgataac aaaattgaac aatgataaga aaaaaacagc acctgctacg 1972921 acaggtgctg tttagctaca tttatttcac tgctgtaaga gctgcatgct cgacagctgc 1972981 tgctaccgca tgatggactt ttgaatcaag cggctgaggg acaacatcac cttgtttagt 1973041 gcaagctgcg atggcctctg ctgctgcgac aagcatatca tgattaatct ccgtgctttt 1973101 tgcgttaagc gctcctctaa aaatccctgg aaaaccgagt acattattaa cagaacgccc 1973161 gtcagctgca tatgcggcgc cagcctgcag tgcggcctcc ggctcaattt ccggcttcgg 1973221 attcgataaa gccagaatca cttgaccaga acgtacaaat gccggtttta ttaaacccgg 1973281 aacgcccgtt gtagcaatga caatatcaca tgtttccata agctcctcaa tactggaaac 1973341 tgcctgtccg ccgtattgtt cgagacggtt cattgctgac tctgatttgt ctgttccgta 1973401 tacagcattc acaccataag ccatgaacat ccggcagatg gccacgcctg ctgcgccaag 1973461 gccgatttgc cccactttcg cttccttcag gtcaaccccc gcactcctgc atgccgaaat 1973521 ggcagctgcc agcgtcacta cagctgtacc atgctggtca tcgtgcataa cagggatgtt 1973581 cagctcctct tttaggcgat cctcgatttc aaaacaatgc ggcgaaccga tatcctcaag 1973641 aaggatgccg ctaaagcccg gagaaatatg ttttactgtt ttgatgattt cttcaggatc 1973701 actcgtatca agcagtatcg gaatgccgct aatacccgcc agctgatcaa ataaagcagc 1973761 ctttccttcc atgacaggca tgccagccac agagccgata ttcccaaggc ctaaaattgc 1973821 ggttccatcc gttacaattg caacagaatt gctgatcgtt gtataaatag aagctttttc 1973881 aggttctttt tcgatcagtc ggcacacgtc cgcaacacct ggtgtgtaga cacgtcccag 1973941 ctctgccagt gaacggatcg gcattttgct tttcatttgg atttttccgc cttcatgtgc 1974001 ggacaggact tcatcagata cggtgtgaag cctgatccct tctccgaggg cctgtacagc 1974061 cgcgatcact tcctgaagct gttcttcatt ctccacttga acggtaatat tccgcattgt 1974121 gtaattgggt ccgactttta ccgtctccac ttcaccaata tccccgccca gaaggccgat 1974181 ggccgtagcc acccttccaa gatttccggg aaccgaaggc gtttcgatca tcagtgtccg 1974241 aatcatgtgt ttcgctatca ttcagtgatc ctcccctatt agcctagttt ttcggcttta 1974301 actgtattgt ttttcgtata ccatataaat tttcctgtat aaccatagat aattgcaaga 1974361 cctattgcta caaaactgag ccacataaac ggcagataag agaaggtaga aacacctaaa 1974421 ataccagcca tgtaaatccc attatcagac caaggaacca tccccgaagt caatgttccc 1974481 ccgacctctg agttacgtga taacactctt ctgtccagat gtaagcgatc atagctgtct 1974541 tccataattt tcggagtcaa aataagagat acatacatcg cacagccgaa gatgtttgct 1974601 aaaaacgcta cgatcagtgt agacaatgtg acattgccgg ctgaagttaa tttcttttca 1974661 aacgttgaaa caatgacttt taacacgccg agtttctcaa gcagaccgcc aaaaccaagg 1974721 ccaaagatga tgacgacgag agaatcaagc ataccgacaa ttccaccgcg gtttaacaag 1974781 ccgttcaaaa attcaacatc cgttttaata gagaagccgt tgtacgcagt tgcaatcgca 1974841 tgggcaatat ccattccttg gaaaacaaca gcccagattg caccgagtaa agcgccaatt 1974901 acgataactg gcatagatgg ctttttcatc gccaataaga ctatgacgag aactgccggg 1974961 atcagcatcc aaatatgaat gtcaaacgtg ttttgcaaag atgattttaa gaattcaact 1975021 ttatcaagat caatattttt cccgccgtac ataaatccaa caactgtaaa gagtatagct 1975081 gtaatgacat aagcaggtat tgataaataa agcattgctc tcacgtgagc caatacatcg 1975141 acttttgata gtgaagaagc tagaactgta ctgtcagaca gcggagacag cttgtcccca 1975201 aaataagcac ctgaaagaat agctcccgct actagaggaa gcggaatgcc taacccctct 1975261 ccaattgcga tcatggcaat gccggcagtt ccgactgttc cccatgacgt tcctgttgcc 1975321 acagacataa tggaacaaat aattaacgtt gccagtaaaa agatacttgg gtgaataaat 1975381 tccagtccgt aataaatcaa agtcggcaca acgcctccgg caatccatgt tccgatgagc 1975441 gccccaactg aaacgagaat cagtacggct tcaaggccat ttgatatccc atgtacaatc 1975501 gcattttgta aatctttata agaataaccg agtctaatac ctaaaagcat tgcaataaac 1975561 catgaaacaa aaagcgccag ctgtatcggc aagtcgagaa agactgtaaa cgatagaaca 1975621 agtgctaaaa atactcctag tacaataata atttcaaata gtgttggcaa tcttacatcc 1975681 ttcaaaagaa gtcccccttc atgtaaaagc taaaacgctt tcaatatata gtgcaacacg 1975741 tatactatac ttcctcatcc ctatgttgta aacagcttat tcatccgact attcggagat 1975801 gaataagctg tattttatac aaattttatt tttctaatag ttctttccct gcgatacctg 1975861 gtttggtcat ctcatatggg tttaaaataa tatccaattc ttcttcagtc agcacatcat 1975921 gctgcagaca aagatcccgg acagattgcc ctgtcataat tgcttccctg gcaattctag 1975981 ctgccgcttc atacccaaga tgcggattga cagctgtgat cacgcctgcg cttttttcta 1976041 cgtattgctt catacgcttt tcgttggctt caatgccttt taagcagttg tcagtgaacg 1976101 aacggaagcc gttgttcatg atgctgatgg attgaagcaa attaaagaca agcacgggct 1976161 ccatgacgtt caactcaagc tggccggctt ctgaagcaag gcagattgta ttgtcatttc 1976221 cgataacctg gaacgcaatt tggttgatca gctccgccat aaccggattg actttccccg 1976281 gcataataga tgaacccggc tgacgtgcag gcagagaaat ttccgcaagt ccggcgcgcg 1976341 gtcccgacgc cattaagcgc aggtcgtttg cgatcttcga catgttcatc atgcagactt 1976401 ttaatgaagc tgatacctct gtataggcat ctgtattttg tgtcgcatca acaagatgat 1976461 cagcgccgac aagaggaagc ccgctaatat cagcaaggtg ctttactacc tgtttgatat 1976521 attcaggatc agcgttcagc cctgtaccaa cagcagttgc gcccatgttg acttcataca 1976581 ggtgctggcg cgattgcttg attcgtttga tatcacgctc gagaacacgg ctgtaagctt 1976641 cgaattcctg gccaagacgg atcggaaccg catcttgaag gtgtgtccgg cccattttaa 1976701 taacagagtc aaactcctgt gctttttgct taaacacact atgcatatct tccattgttt 1976761 tcagcagttt ttctaagagc ttcaatgtgg aaatatggat agcagtcggg aacacatcgt 1976821 tcgtagactg tgacatgttc acatgtgtgt ttggacttaa atggatataa tctccctttt 1976881 tatgtcccat gatttcaagc gcccggtttc cgataacctc attcgcgttc atgttcatag 1976941 aagttccggc accgccctga atcggatcga cgataaactg atcgtgccac ttgccttcca 1977001 gaatctcgtc agcggcttgt acgatagctt ggccaattcc ttcatacagc cgtttcacgt 1977061 ccatgttggc aagagccgca gcttttttca caatcgccag tgcgttaatc atttcctcat 1977121 ggattttgta tcctgtgatc ggaaaatttt cagaagcacg gagcgtctga attccgtaat 1977181 aaacatctgc ttcaatttgt ttttccccaa ggaagtcttt ttccacgcga tattcttttt 1977241 ggccgtttaa cataatcttt aaccttcttt ctctttgctg gttatcgttt ttacatttta 1977301 caggacaacg tcatcagcta tcggcgtttc cataattctc ttgacgacag gaagatccga 1977361 agactgacct agcgcccaca tcaattttgg cacaattgct tctgtgttca tatttcttga 1977421 tcggataatt aagtcttggt tgactctgcg gccaacctcg taaatgctca tgtcttcgcc 1977481 ttcttcaaga cattgagtcg taatgacgac gacaatgccg ctttcgatca gttcattcac 1977541 ttttgacaaa atgtctctgc cttcaaacgg cactcctccg ctgccataac tctcaatgac 1977601 aattcctttg tacatgcttt tcagggcatc aaacatttcg ggctttaagc ctggatgcag 1977661 cttcagcaga catacatctg tgcatagtga agtgtcaact gtgaaggtgt cgttctcagg 1977721 ttccgttact tgtttgttgt attcgatccc gtcttcattg ataaaagcga tatatgggta 1977781 attgatgctt tcaaatgcgt cgtagctttt cgttcttaat ttgatcgcac gcgttccctg 1977841 aatgactctg ccgtcaaaca caacataaac gccgcccacg ccttcacagg caaatcgaat 1977901 ggcatctgta atattttttt tggcatcggt tttttggaac gtgatcggaa tctgcgagcc 1977961 ggtgatgaca atcggctttt tggcatgctg cagcatatac gatagtgcgg cagatgtata 1978021 ggccattgta tctgtaccgt gagtaataac aaacccgtca taggcatcat aattttcctt 1978081 aacggcttct gctatttcca cccagtattc aggctgcata ttggtgctgt ctatattcat 1978141 aagcgactga gtttccattg tgtaatcgtt atcaagtttt gatacgtaac ttaataattc 1978201 atcagccttg actccgggag ccagcccatt ttccccttca actgaagcaa tcgttccccc 1978261 agttgtcaac atcaataatt ttttcatacc atgcacctct tcactgtatc taaagatggg 1978321 ttgcgagaag gtattcgctt ttcgcatact tttaatgcaa ttatagacac ggaaaataaa 1978381 atacgcaaga cattattatt caattcgcgt acacttccta atacctatat gatataatca 1978441 gctcaaggtg aaaaaggagc ggaagttcat gaatctagat cgtttaactg aattgagaaa 1978501 aaagaaaaat tggtcgcttc aatatacagc tgaccttctc ggtatcgcaa aaagcacata 1978561 tgccggctac gagtcaggct accgacggcc ttcacttgaa gcgcttgcca tgctggctga 1978621 cctctttgac acaacctgcg atgaactttt aggccgcgag aaacaaaagc agactgctcc 1978681 tcaggccata gaattggcca cgtggagcag cctcgacttt accatttctg ttgatggcca 1978741 gccgctgagt gaagatgaaa tcatccagct gattaccttt atacgcacaa aaagaaaagt 1978801 acaggaggaa ctgagttaat ctttagctca cggtttaatt ttaccgtagg ttcctcctcc 1978861 tccggctttc aattccagtt ttccggatct cgcttttacg ataagcgccg cggttttcgg 1978921 cgggacaacg cgagccaaat cttcttctgc agcctcatga agaacagcca tttctgttcc 1978981 gaaggctttt tttagtttgt ccagcgtttt cgggcctaca cccggaacaa attgcagcgg 1979041 gatctgatgt acatatcgcg gacgcgggac gcgaacttca agctgatcac tcaattcacg 1979101 caatctatcg ctgactccct tggtaaatct ggcttttccg caattcgcgc acgctgtttc 1979161 cccgcttaca gcaggctctc cgcacgcttc gcaagccgtc tgataatatt tccccaataa 1979221 cgggtccaag ccataatttg cgataatttt cctgtcatct tgtcccttta atgcaagagc 1979281 aaattcagta aaatcagctg actgcacata taattcatta tattctctgc cgattttccc 1979341 caacgaatgc gcatcagaat ttgttaaaaa aggatacgga ttcaattgcg atacgtgtga 1979401 tgccatgtct gtatcacagc ttaatccaag ctccaccgcg tctatcatag atggatcaaa 1979461 aacctcagtt aagcttgatt taaccccttt tccatataag cttttatgcg gcgtaaagat 1979521 atgggcgggg ataaacaggc cgcccatatc ctgcactttt ttttgcaggt ttaagcccgt 1979581 ttcataaatc cgctgcgagc ttaaatgaat atttttcagc cgggctgaca gccagtttga 1979641 aaactgtttc atatcagcca gcgtcggcat aaatacgagc acatggatcg gtccgctgca 1979701 ggcttcatca taaatctcca gctcgctccc caataaaaga gtcgtgctgc gataacggat 1979761 tcctcccccg tcaagctcgc gatattttcc agatgaaatg ccttcctcaa gctctagaat 1979821 gacttccgga gaatgacagt cgataatgcc gaggagttca attcctttat gttcactggc 1979881 ttcaaccaaa attctgtcca gcgttaatgt tttggcgcct gttattttga cagcccttcc 1979941 tgtaaaggtc cggccgatat gaatgtgcaa atccgcgtaa atctttttca tttttgtgct 1980001 tggagcgctt ctttcagctg aagatactga atcgcgtagg ctgttttagc atcatatact 1980061 tcacgcgatt caaccagctt tagcgcatct tcaagcgtca cctccatcac ttcaacaaac 1980121 tcgtcctcat caagctcccg tttttcttca agcacagaaa gctcctcagc aagaaaaacg 1980181 tgaacgattt catctgcaaa tccgggtgat gtataaaacg cagttatttt tgtcagtttt 1980241 tttgctgtat aaccggtttc ctcttcaagt tcccgaagtg ccgtatactc cggctcctca 1980301 cctttttcaa gcttaccggc cggaatttca acgatcgtcc gctcaagcgg cttacggaat 1980361 tgtttgacca tgatgatttt cccttcatct gtgacggcta gtaccgctac agctccaggg 1980421 tgtttcacaa tttcacgttt actggctttg ccgtttggca gctctacatc ctcgacataa 1980481 agatcaatga ctttacccga aaaaatctgt tctttggcaa ttgttttttc ttctaatgat 1980541 ttcatttctt catctcccgt tctgtctcta tatgatgccc catacatttt atcatactag 1980601 agcaaaaggg ggcttcttcg tgaaagtgca ccgcatgcca aaaggtgttg tcttagtcgg 1980661 aaaagcatgg gaaattcgag cgaagttaaa agagtatgga cgcacatttc aatatgtgaa 1980721 agattggatc tcaaagccat aaaagttgaa actttagctc ctttatatta cggtcaatac 1980781 aaagcctaaa aaaggagtgt gcacatgaga aagcgcaaat tgggtacatc tgatttagac 1980841 attagcgaag tcggactcgg ctgtatgtct cttggaactg aaaaaaacaa agcattgtcc 1980901 attctggatg aagcgatcga gcttggcatc aactatttgg acacagcgga tttgtatgac 1980961 cggggacgca atgaagaaat tgtcggtgat gcgatccaaa acagacgcca tgatattatt 1981021 ctggcaacaa aagcgggaaa ccgttgggat gacggaagcg agggctggta ttgggaccct 1981081 tcaaaagctt acataaaaga ggcggtaaaa aagagcctta cacgtctgaa aacagattat 1981141 atcgaccttt atcagctcca cggcggcacg atagaggaca acattgatga aacgattgaa 1981201 gcgtttgagg aattaaaaca agaaggtgtc atccgctact acggcatttc ttccatccgc 1981261 ccgaatgtga ttaaagaata tgtaaaaaaa tcaaacatcg tcagcattat gatgcaattc 1981321 agcctgtttg acagacgccc tgaggaatgg ctcccgcttt tagaggaaca tcaaatcagc 1981381 gtagtcgcca gaggtcctgt tgccaaaggg ctcttaactg aaaaaccgct tgatcaagct 1981441 tcagaaagta tgaaacaaaa cgggtacttg tcctattcat tcgaggaact gacaaatgcc 1981501 cgtaaggcaa tggaggaagt ggctcccgat ctttccatga cagaaaagtc gctgcagtat 1981561 ctgctagcac agccggctgt cgcttcagtg attacaggcg ccagtaagat tgagcagtta 1981621 cgggaaaata ttcaggcagc aaatgcacgg cgtttaaccg aagaggaaat caaagcgctc 1981681 caatctcata cgaaacaaga catttacaaa gctcatcgct catagcagaa aaaccagcac 1981741 ctgtacgggt gctggtttat ttatattgat gccaatccat ttggctttca tttaggagtt 1981801 cttcaaagct cttatttttt tcgatctctt ttttctttct aatctgttct gctttttctc 1981861 ttttctgcct cttttcatcc tcttccttca attggctctt catctccata agctttgctt 1981921 tgatatcgga ttgaaggccg tcttttagct ggtgtttgtc aatggatttt tgttttttca 1981981 tgcagacttc ccccatgttt tgttttgaag ccagtttatc acggagcata taaactgaac 1982041 aagcagactc tcttctgatc actttctcag cgtagcagtg tttaggtata atgatcttaa 1982101 acacgaattg cctatatatt tcgttgaaag gtgctgtgac ttttgaagaa aatccttttg 1982161 gccattggcg cgctcgtaac agctgtcatc gcaatcggaa ttgttttttc acatatgatt 1982221 ctattcatca agaaaaaaac ggatgaagac attatcaaaa gagagacaga caacggacat 1982281 gatgtgtttg aatcatttga acaaatggag aaaaccgctt ttgtgatacc ctccgcttac 1982341 gggtacgaca taaaaggata ccatgtcgca ccgcatgaca caccaaatac catcatcatc 1982401 tgccacgggg tgacgatgaa tgtactgaat tctcttaagt atatgcattt atttctagat 1982461 ctcggctgga atgtgctcat ttatgaccat cgccggcatg gccaaagcgg cggaaagacg 1982521 accagctacg ggttttacga aaaggatgat ctcaataagg ttgtcagctt gctcaaaaac 1982581 aaaacaaatc atcgcggatt gatcggaatt catggtgagt cgatgggggc cgtgaccgcc 1982641 ctgctttatg ctggtgcaca ctgcagcgat ggcgctgatt tttatattgc cgattgtccg 1982701 ttcgcatgtt ttgatgaaca gcttgcctat cggctgagag cggaatacag gctcccgtct 1982761 tggcccctgc ttcctatcgc cgacttcttt ttgaagctga ggggaggcta tcgcgcacgt 1982821 gaagtatctc cgcttgctgt cattgataaa attgaaaagc cggtcctctt tattcacagt 1982881 aaggatgatg actacattcc tgtttcttca accgagcggc tttatgaaaa gaaacgcggt 1982941 ccgaaagcgc tgtacattgc cgagaacggt gaacacgcca tgtcatatac caaaaatcgg 1983001 catacgtacc gaaaaacagt gcaggagttt ttagacaaca tgaatgattc aacagaataa 1983061 aaaagcgaaa ggcctcttcg gctctttcgc ttttttatgt tacagaacgt cggtaatgcc 1983121 atccatattt tctctgatcc attcaatcgc aagatctatc gttgtaaact cctgcgtctc 1983181 gaaggtcatt tcatcctgca atagccagac atctttcttg atggactctg ctcctccgat 1983241 tgaccagtga agcaaggtat aaggatggtt ttgattcagg aaggataccc acgttttatt 1983301 ttgtgctgtg ttcttcattg ccttcagctt ttgttccacg tttcgcgtct cctactttac 1983361 taatatgctc attctggggc tgagcatttc agccgggctt ttcagcgcca atgttttggc 1983421 tttttcattg taatcgatcg tcatttgatc gtcaaaaaac actttttgcg acgattggat 1983481 atacagcgga atgccgttcg tttccagctg ctcgcactgt cccgttaatt cttctgccag 1983541 ccagattgtc gggacaccgc ttaccgcgca gccgcatcct tctgcatcgt aacgaagctg 1983601 ggcttttttt cccgggttgg cgtcaaacgc ctgctgcagt gcctgttttg ctgcatctgt 1983661 cacatgtatg ttcataaggt gaaacccccg ttttcatcat tttcgctatt gtagcataca 1983721 atactgccat tcgcattgtt tctgcctttt ttccaccgct tcgcattttc ttctgcagtc 1983781 ttgatccact catctttccc ttgtatatac tgattgatgc tgtcagggtg ctgggccgcc 1983841 agctgttttt tgagaacggc gtattctttc gctatgtttg gatgagctct gagataatct 1983901 ctgaataaca gatgcctttc aatagcaggg tttccctgtt cgtacatatg gacatgatga 1983961 gtgcgtttat ttccgccctt ttggaaataa cgcctgcccg ctataccgtt ctcacctttt 1984021 ggtgtatagc cgttggcctt catttgttca tcaaattggc tcacggcttc aatgcttctg 1984081 acttcaatta acatatcaat gattggcttc gctgccatgt taggtattga tgtgcttccg 1984141 atgtgatgaa tagcgataat ctccggcccg aacacaagtt tcagccgttc tttttcttca 1984201 tcgaaacatt ctgcccattt ttcgttgtag agaatgatct caacttttct tttcggatac 1984261 aaatgaaaga ccgacagcaa tagaccctgc gctgctttga cggtttctgc cttttggaat 1984321 ccggcctgtg tatagagtga cacagccggg gtattgttct cggctgtgac tacttcgatt 1984381 ttctcagcgt cttcattatg atcaatgaca aattgcagaa gcgctcgtcc aattcctttt 1984441 ctgaaaccgt caggatgcac aacaagcctg caaatggtga gataatgcat gtttttctca 1984501 tatgaaatga caccgatcag cttgccgttt ttccgatatc ccgcaaaccg ttcatgggat 1984561 gcttgaatat cctttacctt ctcttgtaaa gcgggaatac cgtcaaaacc gataatctct 1984621 gtttccttta tgtaggcggg gatctgtacg gctaaaatct cacgcgctat agtggcttcc 1984681 ttatgctgga gaaattcaat cattcgtgtt ctcctgaaac agccgctgtc tgtcgacttt 1984741 tgcgacgcgg actgcatacg actcgtacca aacgcttctt cctttttctt ttgctgcttg 1984801 atgttcagtg tgatgcctcc aatggttaat tgcgtccata ctgtcccaat aggaaactgt 1984861 gatgcccctt ccatccgctt cacgtacgct ttccacgcct aaaaatccag gctgatccgc 1984921 cgcaagtgat accatccgct ccgctgtttc tccatatcct gtgtcatttt cgcttttgac 1984981 agaagaaaaa atgactgcat agtaaggagg ctcaggtgtt tttgataaaa aatccatcat 1985041 atttccccct catatgtttt tgacaaatag taccctgtct tggcccgggc catcatagtt 1985101 tgcaaacact gagatgccat ttaccgtttt ggtgcccttt tcaatatcaa accccaattt 1985161 tgtgtgatat gcgattgata ccttattcac aggtgaagtg acacacttca cccgggtgca 1985221 gcccctttgt tttactgttt cgataaatac atcatacaat tgtttcccaa tttgcatttt 1985281 tctgaaatcc ggatgcacac cggaaaaatg aatgtacgcc gtttcaggat cggattgcga 1985341 ttgaaatccg attaaaaatc ccgtcatgct gttatgttcg gatgtaataa agcttgtgtc 1985401 ctgaaaatgc tcaaaaaata gtctcggcaa tttttctttc agctgtctgc cgccccacca 1985461 ttcattcagt acagacgtta ccatttcata atctgaagac gtgattgttc gaatatccat 1985521 tacgatttga tctccctccg tctggcaaaa cgaatgtcag ctctttttct cacaatataa 1985581 aaattatatt ttgcctggct ggaattgtaa atgccttctt tcctgtatca tacgtttcca 1985641 gactgccgag ggaacaatgt ttgatcattt tacgcctatt tctcccccaa acaggaggag 1985701 agactttaca gcacaatatc aagcacttga tcaagtttca gcttataaag ctgatcctcg 1985761 tctcctttta tccatactgc tttttcaaac tcttcatacc ggcagatttt cccggtgcag 1985821 cagacaatct caccgtcctg aaagcagctg acagtgatat cctgagcaaa ctccatcgcg 1985881 gcgcaaagcg tttgattcat ctcttccagc ttatcggggt caaggatcgg cttttgcagc 1985941 ttctgtttaa gtcgctttct ctccagcagg ctttgcttat gttccggcag aaacatcctg 1986001 ctcccttccc acagcaggtt gccccttttt aaatggtcgt tcatttataa tgccccccta 1986061 ttttagccgc acgttcaaat gcctggcctg ccgctgtcag tgacgccgcc ctgatgattg 1986121 ctgtatcgcc gaatcgattt ttaatgccat ccatcacata gcctaggctc attttctttg 1986181 cataatcctg aaataaattg agctgccata tgtcatcaga tgagagctga gacagattga 1986241 caccgaggcg gcggacgggt ttcccgtccc aaaatgtaag aaacagccgt cgtacagcct 1986301 catatacatc ctgcgtagaa ttagtcggct ctgccagctt cacttgccgg ttgaagcccg 1986361 tcggccaatc aaaatcagca ccccggcagc tcactgacac tgtctgcccc atgaccccgg 1986421 cgtttcggct tcgcctgcac acctcttcac tcagctcaag caatacgacc ttgatttctt 1986481 tgtcaaagtg ttcgtagtct ctcgggagag tcattccatg acctatcgcc ttttgcccgt 1986541 ccagagacga agttgacaca ggggaatagt cgattccgtt tgccgtcatc cacagcacgt 1986601 ggccgttaat gccccatttc ttttttaaaa gatcgagcgg aaaagccgcg agcccgccga 1986661 tcgtgctgat gcccattcga tttaaatgat gcttcatgcg gctcccgacg ccaaacatgc 1986721 tgcccaccgg gagcggccac atttcggttt tcatattttc tttcgttaag gtaaaaatac 1986781 cgttcttatt ctttttggca aaattgtcac acgcaatttt ggccagcgct ttgttagggc 1986841 cgattccgac ccgtgcataa acgccgatct cccgcatgat tctgccctga atgcttttcg 1986901 cgatctccat cggcgtccca aacagcttct ggctgcctgt aatgtccatg aactgttcat 1986961 cgatggaata cggctccaca aggtctgtat actcctcgag aatggccgta atttgcagtg 1987021 atacatcaat ataccgctgc atacgcggcc ggagcacaac agcctcagga cacttttcct 1987081 gcgcctccca cagccgtgaa gcattcacca cacccttttg tttcgccagc gggcaggcag 1987141 ccaatacgac tccgcccctt ttttcagggt cacccgaaac aatgacgggc ctatttttca 1987201 aatgtggatt ttccgctttc tctacagatg cataaaacga ttgcatgtca acgagaaaaa 1987261 tcactttttc tttcatcata cacacctcta aaaagaactt atgttcgctt ttcattatat 1987321 gcgaaagtat gttcgtttta tactggtaaa tgattcttgt ctgacagaaa atatgatcca 1987381 agggtttgag agaagaaaaa catttagtag aataaaagcg aagcataagg ataggagagt 1987441 catgatggag aaatttgtcg aaaaaatgct gggacaggca ttgcggcaat acggcagaaa 1987501 cgttgctata gatccgttaa gcccgtatga aaaacaaagc ctgaaagcgg ctctacaaga 1987561 gagacggaat gaagaaccag atgaggattt gcatgcgcat atagaagata tcatttatga 1987621 ctatgtcaca aaccaaggcc tgttctctta aacgcatgac tgtcagttct ttcagccgct 1987681 gatgcggctt ccctttgaaa acaccgcctg aaacaaataa acagtctcag gcttacagaa 1987741 aaaaagcagg attttctcac gctccataga ttcatatggc ctggcgtaaa attcccctca 1987801 atgctcgcgc aaaacggaat aagctgtcca tgatcacgcg tatacacttt ttcgaagaga 1987861 tgtgctctct tgttctgtca tgcggtccat gccggttttc agcgtacatc ttgatctcat 1987921 agccggtttc actgccgata tgatccacgt tctggcggct taaactaaca caccctcact 1987981 gaccaatcgc tttgcttttc atcggacatc ccgtcatttt ccttctttca agatgtaaac 1988041 tccgtcagcc acacgcatcc tcaacgcata gtatattgcc atccatacaa tcaggcatac 1988101 tacatgtcaa taacgaaata ttttgaacga tctattggag aaggaaattt tttcatatat 1988161 gatagagaaa gatcatacat acaggagaga atataattca tgaagaaatg gaaagatatc 1988221 cacccgatca gctggacaat tataatcgga accattttcg gcagaatggc aacatcgatg 1988281 agcattcctt ttttagcgat ttatttgaca gccgtccaag gcgcatcagc ttcctatgca 1988341 gggctggtca tcgccgcgag ctcatcagtc ggcatcctcg caagctttta cggcggatat 1988401 atctcagata aattcggcag aaaaaacatg atgcttgtat cgattttcgg atggatgctg 1988461 gtatttgcag gctttgcggc agcatctaat ctctgggtgt tttttgtagt aaacgcatta 1988521 aacggtcttt gcaaatcact gtttgagccc gcttcaaagg ccttgttgtc tgatatgaca 1988581 gaagaaaaaa cgagactgct agtttttaat ttacgctatg cggctattaa tatcggcgtt 1988641 gtcttcggac ctgtgcttgg cctatatttc ggctcatcgc aatcgactac gccctttttg 1988701 gtgcctgcag tcatttacgg actatacgga attgtgcttg ccctccaatt taaaaaacat 1988761 ccatccttat cagcaccagc ccagtcccga aatatgagcg tgcgggaagc gtttatggtc 1988821 acgcaaaagg attatctttt taccattgct ttggtcggca ttacgctatg caccttcggc 1988881 tactcacaat tcagttccac attccctcag tatatggcgc agaacccctt gatcggcaat 1988941 ggaacgaagc tgtatgggct gatgctgaca ttaaacgcaa tcgttgtgtt ggcgacgcaa 1989001 tttcccattg tccattttgc aaaacggttt tcgccgcttt gttctctgat gctcggtaat 1989061 gtgatggtta gcatcagcat ggccattttc accgtatcac acggtgttcc atcaattgtg 1989121 atgattgtca tcacatttac aatcggcgaa gtgcttttat tctctatgat ggatttgtat 1989181 gtagaccaga ttgcaaaacc aggattaaaa ggcacttatt tcggggcaat cggtttttca 1989241 cagctcggaa acgtcatcgg cccttgggtc ggggggatat gtatagacct gtttggcgct 1989301 ggccggccga tttatatttt ttctgtcctg agcggcatta ccctgctcgg cctgccattt 1989361 ttagcgttcg cctatcggca aatgaaaatg gagaccacaa aacaccgttc ccgtctggaa 1989421 aagccgcttt aaataaaaaa cggaagagaa tgaatctctc ccgcaaacat gaggtgaaga 1989481 acatgaatat aggtgatgtg atgtttcagc tgtttgtatt tattatattt gccgctgtcg 1989541 tctttgcggc tgttacaggc ttcaagtatg cgaaaaaccg aaaagcgcag ctggatcgca 1989601 ttgagaaaaa gctgaacagc ctgtccgaag atcacgatta acagcttggg gcaacgagct 1989661 ctaccttaat ccggtctgga tcctcacaaa agactgcata atgcccgtct cctccggcaa 1989721 aaggatgcct gtctcggtac aacacacgat agccttttgc cgtcaatttt tcagtcatct 1989781 gatcgacttg aagcttggat tcagcatgaa atgcgagatg gttcagaccg actcggcatc 1989841 tatggtattc cggctctaga aatggctctt tcgcctgcac aatcactagg taaaaacgat 1989901 ctttcttcca gctgatgcct gagctccatt tttgatactc tttataacca agttctttta 1989961 agaaccagcc ccaaaaccgc ctagacgcct ccaaatcaga gacatacagt tcaatatgat 1990021 gcacatttca taccctcctt accaacactt cctcgacctt atgcccgtct cccttacgca 1990081 aaatgagatc tgacctgaat ttagttggca aaatattttc atataaattc ggccggttga 1990141 cactctccca aatcgaggct gccatctcgt cagcctcctg atcggacaag tctttaaatt 1990201 tatgaaaata tgaatcagga ttttgaaaag ctgtttcccg aagcaggcga aaacgctcta 1990261 aataccaagt gaaaatccgg ctttcctccg catccacata aatcgaaaaa tcaaagaaat 1990321 cggaaacaaa aatacgcggg ttttcccggt catcctccaa ggtgggcgac tgaagaacat 1990381 taatgccttc aataatcaca atatccgcct gttctacaac ctcgaacaca ccttcctcgc 1990441 ggtcataggt tagatgggaa tacaccgggg cctttacgct gtcctttcct gattttaagt 1990501 cattcaaaaa ttcgagcagc gcctttacat catagctttc aggaaatcct tttcttgaca 1990561 tcatattttt ctttttcagc tcggcagtag gaaataaaaa accatctgtc gtgataaggc 1990621 tcacttttgg acggtcaggc aaacgcgaaa gcagcttctg caagatccgc gccgtcgtgc 1990681 tttttccgac tgcgacactg ccggcaatgc cgataataaa cggaattttg gctgaatgtg 1990741 ggtgcttcaa aaaaacattg acatgcttat tgcgttcagc cgcagacttg acatgtaaat 1990801 gaagcaagcg aacaagcgga atatagatcg tctccacttc ttcaacagat agataatcat 1990861 tcaatccttc cacagctttt gcctcttctt cagatacagc aatcgacaaa tgccccccaa 1990921 aaccagacca agactcccga ttgtgctgtg tatataaagt atgtaggtta agttctttat 1990981 ttttcactgt ttacacctga ctctctgtag gttaaaaccc ttacaaagat tgtaacggaa 1991041 aaccttttca ctgtctgctt atttttcatt tcgttttttt agcaaatcag caccgattcg 1991101 gttatacgca gccatttcat cttttggaac catgcttcct cccgttcccc agacgacatg 1991161 tacggcatgt tccatcttat atttctgagc atagcgcctt ccctcttctg tcgaaaaaag 1991221 ctgaaccggc ccgaacatgc cagcaagagc agagggctct aaatatttat cttcagatac 1991281 agccagcata tgaagcaaag tataaagcgt attgtcctct accgtataac agccgctcag 1991341 aagcggttca atcagcttgc cgacaaatcc tgacggcctc cctacggcaa gtccgtcagc 1991401 agccgtctga ttatccaggc cgatatcctg gacggagatc ttctcgtgaa gtcctgaata 1991461 aagccctaac agcatacaag gtgaatgagt tggttctgcg aaaaacacat gaacatcatc 1991521 tccgtataaa agcttcagcc caaatgctac accgcccggt cctccgccga ctccgcacgg 1991581 cagatacaca aacaagggcg tctcaagact tggctttata ttcatacagt caagctgtgt 1991641 ttttaatcgg cttgcagcaa cagcatatcc taagaacagc tgacgagaat gttcatcatc 1991701 aataaaataa cagaatggat cttgttccgc ctgccgtctc ccttcgttca ccgcttcact 1991761 gtaatctgtt tcgtactcca taacagtgac tcccttttgg cggaggagat cctttttcca 1991821 ctgcttagca tcggcggaca tatgcactgt cacgcgaaac ccgagtgccg cgccgatgat 1991881 gccgatgctt aaacctagat ttcctgtcga accgacagca atcgaatagc gggagaaaaa 1991941 cccggtaaac cgctcttcct gtaagatgcg gtaatcatcg gtttcctgaa gcattccttc 1992001 ttgaagcgcg agattttcag catactttaa cacttcataa atcccgcccc tcgctttaat 1992061 cgatcctgaa atcggaagct catggtcgca ctttaaaagc catcttccgg gaaatggctg 1992121 ctgatatgcc gcttccagct ttcccttcat atgctgcacc tcaaaaagcg gagactcgat 1992181 gattccttta gcgcctttcg tctcaggaaa cacctcggca atgtaaggtg caaaccgctg 1992241 cattcttttt tccgcttccg ctatctcggt tgcccactca tctgcacggg gtaatggccc 1992301 ctctttcttg cctgaatttg cccagaatac aggctctgca tcaatcagtt tctgaataaa 1992361 cggatcttta agcagagcat gaaggacttc tgaatgaact gacattcaac aatctctccc 1992421 ttccactatc aaaaactgcc ccgtgagaaa caagccactc caccacaggc agttctatca 1992481 ttattttttc atgagcgcgc gtcctgccag cttttctaca agagctggaa acagctgata 1992541 cagcttagtg ccggcattca ttaaacgcgg aagattgatc tcccgctttt tcgtaaaaat 1992601 tgcagctgta atttgagctg ccacgtcatc aggatcaagc atccagcggc cgacattttt 1992661 ggcgtagtcc ccgcctttat cagcaatgga aaaaaagtcc gtctgaatcg ggcccgggtt 1992721 gactgttgtc acataaatgc cggttcccga aagctccatc cgcaaagcgt ttgagtaacc 1992781 taacacggca tgtttggtcg cggaatacag gctagacttc ggtgtggcga ttttccccgc 1992841 ttgagaggcg atattgatga tatgtccctt tttttgctca agcatttgcg gaagcaccgc 1992901 ttttgtacag gcgatcaggc cgaagacatt cacatcaaac atcgctttca tgtcatccaa 1992961 tgtagagtct aaaaccgttt caaatatacc gaagcctgca ttgttaatca gtacatcaat 1993021 cgagccgatc tgatcgcgga cccgggcgat atcctctagg cggccgacat ccagaggaaa 1993081 aatctcacac tgtccgctcc attcctcggt tattttcctt ttgatttcta tcaaacgatc 1993141 ctcgcgtcta gccgacagca ggacatgggc tccttcagcc gcgcataagt atgcgattct 1993201 ttctccaagc cctcctgaag cgccggttat ccaaatcctt tttcccgcta tatgtttcac 1993261 ccatttcacc tcttcattgt tttaaagtat acggtatttc cttcccaata tgacgtgatg 1993321 gcttcttcag cctccaacac atcaaggtga cctgccgttt ctgacatcgt taaaaacaat 1993381 tccttttcat atacagcagg aaaaagctgc tgacagacct gaaaagcggt catcggcttt 1993441 tcatccagca tgcgacgcac atcctccgtc ctgttcctct gcttgtcaaa acgcttctca 1993501 atcagcgctt gtacactggt gataggctcg ccgtgaccag gaaatacgat tgttggatca 1993561 agttgagaca gccttcgcaa tgaccgctga taatccacta aaggctttga cctgacgtct 1993621 cccgctttcg gcgcttccaa aatcggatta gacgagctgt ttgccagcag tagatcgccg 1993681 ccaagcatcc ttccgctttt ttcatggaac agaacaatat gcgattcagc atgtccaggc 1993741 atctccaaca cagaccagcc ctcaagccca tctatgccca taccttctct gattgatttt 1993801 gtcagagatc tcgtacagga aaatgcgtac gctgatcgaa tcagcttttc cgccttcccc 1993861 gtatcaaatg gaacgcctaa ttcaggcagc agcttttgaa aaaaacgttt ttgccaatcc 1993921 ataaaggctt gattttggct gatataaggt tcgttgaatg tatgcccaat cacttcgatt 1993981 tcatctgaaa agacatcaag caagcctgca tgatcagcat gatggtgagt cagtacaacc 1994041 tgctcgatat ctgacaattt cacatttaca gcggcaagct gctcttgtaa ggctctggca 1994101 gcctcttttg tattcggccc ggcatcgata agtgtcagcg catcaccttt tacgaggtaa 1994161 acgataacat cgccgacagc aaacggtgtc gggacgcgga tcgcaattac atcttcagtt 1994221 gtcatccttt cgctccttgt cttcattcat tattcatatt ttagcttttt ctcggtcttg 1994281 tgtcattatt gcagaatgag aacaaacctt tttgaaaaag ctattgacat tagcttgtcc 1994341 gccattgcat aatgaacaac aaactaaaac gagaaccatt ggaacgctat gacgaggaat 1994401 agtatacaag gcaatggcct aagagagcga tacccccggc tgaaaggtgt tgcggcccgc 1994461 ttgtttgtag aacctgccct caagtcgcgg ttaggaaaac ctaaacgttt cccgcgttac 1994521 ggggatttga gctgagcaca atttgtgcta atgagggtgg taccgcgaac cttttcgtcc 1994581 tttacgtgat gaaaaggttt tttgttgttc taatagaagg aggatatcaa tgaaaaagat 1994641 aggatttgtc ggcgccgggt caatggcaga agcaatgatc aacggcattt tgcaaagcgg 1994701 catcacaaaa ccagaacata tctatattac aaatcgctca aatgacgagc gtctgattga 1994761 attaaaggaa acgtacagcg tgcgtccatg cagagataaa aatgagtttt tcactcacac 1994821 cgatatcatt atcctcgctt tcaaaccgaa agacgcggcg gaaagcatcg acagcatccg 1994881 gccgtatatc aaggaccagc ttgtcatttc agtacttgca ggccttacca tcgaaaccat 1994941 tcagcattat tttggcagaa agctcgcggt cattcgcgtc atgcctaata catcagcggc 1995001 aatcagaaaa tcagcaaccg gattttccgt aagcacggaa gcaagcaaga atgatattat 1995061 tgccgcaaaa gctctattgg aaacaatcgg tgatgcaaca ctggttgagg agcggcatct 1995121 tgacgctgtc actgcaatcg caggcagcgg cccggcctat gtgtatcgtt atattgaggc 1995181 gatggaaaaa gcagcacaaa aagtaggatt agataaagaa acggcaaaag cactcatttt 1995241 gcagacaatg gcaggggcaa cagatatgct cctccaaagc ggcaaacagc cggaaaagct 1995301 gcgtaaagaa atcaccagtc ctgggggcac tacagaggca ggtcttcgcg ctttacagga 1995361 ctcccgcttt gaagaagcaa ttattcactg tattgaagaa acagctaaac ggagcgcaga 1995421 aatcaaagaa cagtttgccg gtgccgcctt agagagacat tcttagatgt aaggacaaaa 1995481 acagaaggca cagtgccttc tgttttttat ttttcccgca gcagctggcc ggcagattct 1995541 gattgcttta atagcgcgga gatcgtaaat gaaagcaaat cgggaagcac ttcaaaggaa 1995601 taaggcatat acaatctttc cgtccattta tgcgggtctt taccagccgg accgacattt 1995661 aaaactggga catataaagc ctgattttta ccgcttggca atgaataccc tctgttaaag 1995721 agcggcatat tgcttgtgta tgcatcaacc tcctgttttt ccagctgaag ataactcaag 1995781 tccgaaagtc cggggaagta ctgaacctcc cgtaatgcaa tgccgtatcg ctcagccgca 1995841 taatgcttta tctgatctgc tgtatttctg atcaattgat catcctttga agaaacagct 1995901 ggataaagcg gcggactata aaacagaacg atgagcggcg catcctcctt acaaagcgaa 1995961 gcaagctcag aaacaatttt cgtcgaaaaa tccctgtctc caagctcccc cctgttagca 1996021 aaggcataat ttagagcccg ctctgtttcc gagatccccg cacgcttttt tgcacgcgag 1996081 accagctcat caaatgtcaa aacagtgacg tcccgctcaa tcggctgaaa tggctcaaat 1996141 tgttgaaaat cctgtgtttt cttccgaacg ttcgacatga tttcctccgc cgcctgttct 1996201 gctgttttaa gcagcatctg atgcagctca ctagctgagc gtttcattga cagcacatta 1996261 aataatgtga cggctgtatg cggtgtctgg actgaatatg cctctttcaa gtccttttgc 1996321 attaagttta ccggcggcgg agtgacctcg ccatcaacct tttcgcaata atcagcattc 1996381 agttcaagca aacggttaat ctcagatacc attaaatttg cgtttagacc tgaaaacggc 1996441 tctccaacat gtgtctcaat ccccttgcag aaaaaacccg caagcacctt gccaatgctt 1996501 cctgtataaa aatattgctg ctgatcgccg ggaaattttt caaacatcgg ttcggcattc 1996561 aggcaagcgg ttaatgtgat atcatgcttt ttctccatct ccttcaatgc aggaaccgct 1996621 tcaatcatgc ctcttgaatt cacttcctcg tccggaaccg ttatcaacag cagattgccc 1996681 tcaaaatgcc cgttcattgc cctctccagc atcgacagtt gaatacaaag ccccgctttc 1996741 atatccatcg tccctcttcc gaacagccag tctccgcttt cggcatctct tctcacacgt 1996801 tccgggagca gctctttttt ctctaaaaag gagctcaaaa gctcagcagg cttgcaagcc 1996861 atatgtttaa attcgccgta atcttctatg tcaacgacat caaaatgact cagcagaagc 1996921 actgtctttt tgacattctt ctttttgact agagccgtaa gaaaagatct gccatcgtcc 1996981 atcggatgaa gtgttacatc atcagggtgc ttttgaaaat agggcttgtc cttcaaaata 1997041 aaataaagat actctgcaag cgctacctcg ccctttgaac cggtgatgct ttcgtattgc 1997101 acaagagaag ttaaaagtgc cagcaattcg tccttcgtct gccaattcat tgattccgcc 1997161 cctcctatga ataaaaatgc ttctatactg aaaaataaac tgatttctcg tctattatac 1997221 agaaatgttt gacaaaagcg gttcatttga gcagtttata tgacgggaaa gaaatgactt 1997281 gatataatca atctctaaaa accttacggg aggcgaaaga aatggccaga aaattattta 1997341 cacctattac aattaaagat atgacgttaa aaaaccgcat tgtcatgtcg ccaatgtgca 1997401 tgtattcttc tcatgaaaag gacggaaaat taacaccgtt ccacatggca cattacatat 1997461 cgcgcgcaat cggccaggtc ggactgatta ttgtagaggc gtcagcggtt aaccctcaag 1997521 gacgaatcac tgaccaagac ttaggcattt ggagcgacga gcatattgaa ggctttgcaa 1997581 aactgactga gcaggtcaaa gaacaaggtt caaaaatcgg cattcagctt gcccatgccg 1997641 gacgtaaagc tgagcttgaa ggagatatct tcgctccatc ggcgattgcg tttgacgaac 1997701 aatcagcaac acctgtagaa atgtcagcag aaaaagtaaa agaaacggtc caggagttca 1997761 agcaagcggc tgcccgcgca aaagaagccg gctttgatgt gattgaaatt catgcggcgc 1997821 acggatattt aattcatgaa tttttgtctc cgctttccaa ccatcgaaca gatgaatatg 1997881 gcggctcacc tgaaaaccgc tatcgtttct tgagagagat cattgatgaa gtcaaacaag 1997941 tatgggacgg tcctttattt gtccgtgtat ctgcttctga ctacactgat aaaggcttag 1998001 acattgccga tcacatcggt tttgcaaaat ggatgaagga gcagggtgtt gacttaattg 1998061 actgcagctc aggcgccctt gttcacgcag acattaacgt attccctggc tatcaggtca 1998121 gcttcgctga gaaaatccgt gaacaggcgg acatggctac tggtgccgtc ggcatgatta 1998181 cagacggttc aatggctgaa gaaattctgc aaaacggacg tgccgacctc atctttatcg 1998241 gcagagagct tttgcgggat ccattttttg caagaactgc tgcgaaacag ctcaatacag 1998301 agattccggc ccctgttcaa tacgaaagag gctggtaatg cccataagag atatcctgta 1998361 gaggatatct ctttttttat ttttagagaa acgatcggct aaggttctcc gtctccctag 1998421 tagaaccaat tagaggagat gactccaatg aaatcagctt ggatggaaaa gacatataca 1998481 attgacggat gtgcgtttca tacacagcac cggaaaggat caagcggtgt aacgattgtc 1998541 tttgaggccg gctatggtac ttcttctgag acgtggaaac cattaatggc ggacattgat 1998601 gatgaatttg gcattttcac atatgatcgg gcaggcatag gaaaaagcgg gcaaagcaga 1998661 gctaaacgaa cagctgatca acaagtgaaa gaattggaga gtttgcttaa agcagctgat 1998721 gtaaaacctc cttatttggc tgtttcacac tcatacggag ctgtcatcac cggtttatgg 1998781 gcctgcaaaa acaagcatga tattatcggc atggtccttc ttgacccagc tttaggcgat 1998841 tgcgccagct ttacctttat acccgaagaa atgcacaaat cacatacgag aaagatgatg 1998901 cttgagggca cacatgcaga gttttcaaaa agtctgcagg agctcaaaaa gcggcaagtc 1998961 cacttaggaa acatgcctct tcttgtgttg tcatcaggag aacggactga gaaattcgct 1999021 gctgaacagg agtggcaaaa cttgcacagc agcatattgt ctctatctaa ccaaagcggc 1999081 tggattcaag ctaaaaacag ctcccacaac atccatcatg atgaacctca tatcgttcac 1999141 ttggctattt atgacgtatg gtgcgcagcg tgccagcagg ccgctcctct ttaccaggca 1999201 gtcaattaac gtaaaaaaag accgggccgt aagggattcc cggtctttta tattattttg 1999261 tttcacggtg aagggtatat ttctttaaac gcggtgaata ttttttcagc tccaaacggt 1999321 ctggattggt gcgtttattt tttgttgtga tgtaatttcg gtctcccgtt tcagtgcaaa 1999381 gctaaagtaa catttactct cataattaac atctccttat aaaacgtaat gattacgttt 1999441 tattatacaa cgtcatcaca aattgtcaaa taagagctcc gccttcagcc tcgcgggacg 1999501 tttacctcta agaaatcata tgccgccacg ctattgggga aaacgtcaac cgcttctttt 1999561 tgaagctcca aagaagcatc tccctgatat cttgcgctga tatgggttaa aatgagctgc 1999621 ttcgctcttg cttctttcgc tgttacagcc gcttgttccg ttgtactgtg ataataatca 1999681 taagcaagtt tacggtcttc cttagcaaag gttgcttcat gaacaagcac atcacaatcc 1999741 ctcgcaagct cttttagttt gtcacttact ctcgtatcac cggagaacac aacagatctt 1999801 ccctttttag gaggctccag aaaatcattc ccattgatga ttcgtccgtc ttcaagcgtt 1999861 accgtttcgc cttttttgat tttctgatat acaggtccgg gcgggatgtt catttctttt 1999921 aatacgtcag ccttcaagga acccggtacg tctttttcct gcacacggta cccgaaggct 1999981 tccactccat gaataacaga taccgctgtg acaataaact gatcgtcctc aaacacgatt 2000041 ccttcttcaa tttcctggat cgcaagcgga tatgtcaaat gggttttcgt gacggcaagg 2000101 cttgtttcaa taaacgcctt gatcccttta ggtccgtaca ctgtcagctc gtcctctccg 2000161 ccttgaaagg aacggctccc cagaagcccc ggaagtccgt atacatgatc gccgtgcatg 2000221 tgtgtaataa agattttctc tattttacga ggtttaatcg ttgtatgtaa aatttgatgc 2000281 tgtgtggctt ccccgcagtc aaaaagccat accgaacgcc tttcttcaag caattttaat 2000341 gccaccgacg ttacatttct cgccttggcg gggatgccgg ctcccgtccc taaaaaaagt 2000401 aattccacgt ttccttcctc ctactagaac cagataccta caagaataca ggatcaagcg 2000461 gaaaatgtga atcttgcctc tgaaaagaac aatcctttcg tgctagaaac attttttcag 2000521 cattctgctt aaaaaagggc ttaaatgttt gctttcgttg aattttagat ttaaaatgaa 2000581 ggaaatatac ggggtgtact aaaataaagc ttcgaataaa gtgaggtact tttagtgaaa 2000641 acaaaccaac aaccaaaagc agtaattgtc atattcggtg caactggaga tttagcaaaa 2000701 cgaaaattgt atccgtctat tcaccgttta tatcaaaacg gacaaatcgg agaagagttt 2000761 gcagtggtag gagttggaag aagaccttgg tctaatgagg atcttcgcca aactgttaaa 2000821 acatccattt cctcatctgc agataagcat atagatgatt tcacgtctca tttttactat 2000881 cacccgtttg acgtgacaaa ccctggttct tatcaagagc taaacgtatt gcttaaccag 2000941 ctggaagata catatcaaat tcctaacaac agaatgttct acttggcaat ggctcctgaa 2001001 ttcttcggaa cgattgcaaa aacattaaaa tcagagggtg taacagctac aaccggctgg 2001061 tcccgccttg tcatcgaaaa accgttcggc catgatctgc caagcgcaca ggcattgaat 2001121 aaagaaatcc gcgaagcatt tacggaagat caaatttaca gaatcgacca ttatctaggc 2001181 aaacaaatgg ttcagaacat tgaagtgatt cgatttgcca atgcgatttt cgaaccgctt 2001241 tggacaaacc gctacatttc aaacattcaa atcacatcta gcgaatcact aggcgttgaa 2001301 gaccgcgcaa gatattacga aaaatcaggc gcccttcgcg acatggtgca aaaccatatt 2001361 atgcagatgg ttgcccttct tgcaatggag ccgcctatca aattgaacac agaagaaatc 2001421 cgcagcgaga aagtgaaggt gctgagagca ctgcgtccta ttgcaaaaga cgaagtggat 2001481 gaatactttg tgcgcggaca atatcatgct ggtgaaattg acggtgtacc ggttcctgct 2001541 tatacagatg aagataatgt cgctcctgac tccaatacag aaacctttgt tgccggcaag 2001601 ctcttgatcg acaacttcag atgggctggt gttccattct acatcagaac cggaaaacga 2001661 atgaaagaaa agtccacaaa aattgtcgtt caatttaagg acattccgat gaacctgtac 2001721 tacggtaatg aaaacaacat gaatccgaac ttgcttgtca ttcatattca gcctgacgaa 2001781 ggcattacgc tttacttaaa tgctaaaaag cttggcggag cagcacacgc acagccaatc 2001841 aaactcgatt attgcagcaa ttgcaatgac gagttgaaca cccctgaagc atatgaaaaa 2001901 ctaattcacg actgtcttct tggcgatgca acaaactttg cacactggga tgaagttgcc 2001961 ctttcttgga gctttgtcga ctctatttct gaaacatggg cagcaaacaa aaccttatct 2002021 cctaactacg aatcaggctc aatgggaccg aaagaatctg atgatctttt ggtgaaagac 2002081 ggcttacact ggtggaacat ataataagaa gaaaaaagcc gaaaatgttt acaagcattt 2002141 tcggcttttt tacgctgaac aaaggtataa caatctcctt aataacaaaa cccccaaagc 2002201 ttaagagctt cgggggtttc tattgattac ttcatccatt cagtatggaa gatgccttct 2002261 ttgtcagtac gctcataagt atgagcgcca aagtagtcgc gctgtgcttg gattaagttt 2002321 gcaggcagta cggctgtgcg gtagctgtca tagtaggcta atgcgcttga gaatgatggc 2002381 accggcacac cttgggcaac tgcaagtgaa atcacttggc gaagcgctcc ttgatagctt 2002441 tctacaatat tcttgaaata gctgtcaaga agcaggttgt caagctcagg ctcgcgatcg 2002501 taagcttctt tgatcttctg aaggaatgcc gcgcgaatga tgcaaccacc gcggaagatc 2002561 atagcgattt caccatattt cagatcccag ttgtattctt cagaagcagc tttcatttgg 2002621 gcaaatcctt gcgcgtatga acagatttta ctcatgaaca acgcttttct gaccgcttca 2002681 atcagctctt ctttattttc tgtaacaggc ttcacttctg gtcctgaaag aagtccgctc 2002741 gcttttacac gctcttcctt catagctgag ataaagcgtg cgaatacaga ttcagtaata 2002801 atcggaagcg gaacgcctaa gtcaagtgcg ctttggcttg tccattttcc tgttcctttt 2002861 tggcctgctt tatcaagaat cacatcaaca agcggtttgc ctgtttcttc gtcttttttt 2002921 gtgaagatgt cagccgtaat ctcaatcagg tagctatcaa gctcaccttt attccattca 2002981 gcgaaaactt catgaagctc atcagcagaa aggcccagca cctgtttcag aatgaaatat 2003041 gattcagaga tcagctgcat atctccgtat tcaattccgt tgtgcaccat ttttacgtaa 2003101 tggccggcgc cgtccggacc gatatatgtc gtacaaggtt ctccgtcaac ttttgcagaa 2003161 atggcttcaa gaatcggttt tacaagctca tgtgcttctt tttgtccgcc aggcatgata 2003221 gaaggtcctt taagcgctcc ttcttctccg ccggaaacgc ctgttccgat aaaatgaatg 2003281 ccgctttcag cgagttcttt gttacggcgc tgtgtatctt tatagtatgt attaccgccg 2003341 tcaattaaaa tatcatcctt ctctagatga ggaagaagag attgaattgt cgcatctgtt 2003401 gcagttcccg ctttaaccat taataagatt ttgcgcggtg tttccaagga ttggacaaat 2003461 tcttcaatgc tgtaagtgcc aacaacattt tttccttttg cctcctgtaa aaactcctca 2003521 gttttactgc ttgatctgtt gtaaacagaa acagaaaatc cccggctttc gatatttaaa 2003581 gccagatttt tacccatgac cgcaagtccg ataacgccga tttgttgttt tgacatattc 2003641 taacgtccct tctgcaaacg tttaatcatt ttaaaattta aattaaaata aaatgatatt 2003701 tataataaag aaattaccat acattcaccc tttttttcaa gcgattcagc ttttcttttc 2003761 atcttgaaaa aaatctttat taaagcttgt tccctttgtt ttgctctcct ctttttttaa 2003821 cgttgcccct tttctgatca gtttggtacc gtacttttta ttcagctttt ccatcatctg 2003881 ctgaatgggc tcatccttcg catcttcatt aaagctgaac aaatcgagct gtttataggc 2003941 ctgctctttt tctactaaat ccgttccggt aatgccaagc agcctgacag gatttttatt 2004001 ccaatgttta aaaaagaggt gctccgcttc tttcaaaatg tcattttttt gatcaatcgg 2004061 gtttctcagc gtagtgcttc ttgtgatggt tctccaatcc gcatatctaa tcataataaa 2004121 aagcttcgaa gccatgactt ccttgcgctg taaacggtca ctcacagaag cggcaagctt 2004181 tctaaaaacg cctaacagct cttcttcatc actggaatca tgggaaagtg tcgatgagtt 2004241 gccgacgctt ttaaattcgt aaatgcgctc cgggtcaacc ggcgcatggt gaatgccatt 2004301 tgctttattt ttaaggcgcg gaccgttgat gccaagcagg cgcttcagcg agtgttcatc 2004361 agctgcagct agctctccga ttgtatggat gccgagtccc ttcagttttt ccgctgtctt 2004421 tttgccgact ccgtgcatct ctccaacagg aagcggccac aggatatcgg gcacttgcct 2004481 ctttcttaag atcgtaattc caagcggttt tttcatatca gacgccatct tagcgagaaa 2004541 tttattcggt gcaatcccta tgcttgacgg gagcagcagc tctttttgca gcctgctttg 2004601 gatttctttt gccgtctcta gagcgcggct gctgtatggt gtatcggtca tgtccatata 2004661 gccttcgtcg atggagacag gctccactag gtcagtatat tcacgaagaa tggtaaacat 2004721 cgctcgtgaa gagtttctat agcggtcaaa gttcggcgga agaacgatga gctcaggaca 2004781 atggcgcttc gcttgccaaa ccggcatcgt tgttttgacg ccgcgcgctc ttgcttcgta 2004841 gctgcatgtt accacaatgc cctttcgctc ctttacgttt ccggcaactg cgaccggctt 2004901 tccccggaga gccggatcat atgccatttc aaccgacgca taaaagctat tcatatcaat 2004961 atggaaaata attcggctct ttcccggcat aaacaaatct ccttttcggt cattagacaa 2005021 cagcttgtac atatagtaaa atgaagctat tgaatggatg tgatgacaat gtttgtggaa 2005081 tcgataaatg acgttttatt cttagtcgat tttttcacaa ttattcttcc tgctctaacg 2005141 gcaatcggga ttgcattcct cttacgggag tgccgtgcgg gcgagcaatg gaaatcaaaa 2005201 cgaacagatg aacatcagac ggtctttcac attaaccgaa cagactttct tattattata 2005261 tatcatcgca ttacaacttg gatacgtaaa gtcttccgca tgaattcgcc tgtgaacgat 2005321 gaggaagacg ccggttctct tcttttataa accgcattta taaaaaggag gagaacaaaa 2005381 ttgttaaaaa catatcaaaa acttttggct atgggtatct ttttgatcgt attatgctcg 2005441 ggcaatgctg catttgcagc gactaatcag gtgggaggcc tcagcaacgt aggttttttc 2005501 cacgattatt taatcgaacc gttttccgct ctgcttaagg gtgttgccgg gctgtttcac 2005561 ggagaatacg gactctctat tatcctcgta accattattg tgcgtatagt tgtattgcct 2005621 ttgtttgtca atcagttcaa aaaacagcgc atcttccaag agaaaatggc cgttattaaa 2005681 cctcaggttg acagtatcca ggttaagttg aaaaagacga aggacccgga aaagcaaaaa 2005741 gagctgcaaa tggaaatgat gaagctgtat caggagcata atatcaaccc gcttgcgatg 2005801 ggctgtcttc caatgctgat tcagtctccg attatgattg ggctttatta cgcgattcgc 2005861 tcaacacctg aaattgcgtc acactcgttt ctatggttca gtttagggca atctgatatt 2005921 ctcatgtccc ttagtgcagg gattatgtat tttgtccaag cctatatcgc tcaaaaactg 2005981 agcgcgaaat attccgctgt cccgcaaaac cctgcagcgc agcaatccgc aaaattgatg 2006041 gtgttcatct tccctgtgat gatgacgatt ttctcgctta atgtgccggc agcccttccg 2006101 ctgtactggt ttacaagcgg actgtttttg acagtgcaaa acatcgtcct tcagatgacg 2006161 catcataaaa gtaaaaaaac agccgctctt actgagtcgg tgaaataaaa aagcaacccc 2006221 gtgcaaaaag ccggggttgt tttttgttac ttgcaaagta ccgcgccaaa cagtcttgtt 2006281 tatcatggct gaagcagaaa tggccatcct aaaaaatagc cgtatcgttt aaaaagaagg 2006341 aaatcgggaa tacctttact cacctccaac cgaaaggagc ctatacgttg acggaacgct 2006401 ttcagcaaaa aaatatttct gtacctgatg gaatctggat catgagacaa acctggaatg 2006461 atgtcttatt tgctcactgg cctgttgatg tttctatcct tcgcgctttg gtaccgtccg 2006521 ttttagaatt agatacatat aacgggcaag cttggatcag catgcttccc tttatgctca 2006581 cgaacctgag ggcgcgttat ctccctgtca ttcccggtgc gcgtgcattt cctgagctta 2006641 acctccgcac ctatgtcacg tataaaggca agcccggcat ttattttttt agcttagatg 2006701 ccgatcatcg tctggcggtc cttggcgctc gcacattctt tcatctgcct tatttttacg 2006761 cggatatgaa gtccgaaaaa aacggtgatg ccattgacta tgtcagcaag cggaaaaatg 2006821 acaaagaagc agcattccac gccgcatacc ggccaatttc agcgcctttt acagcagaaa 2006881 aggattcgct cgattactgg ctgacagaac gatacaggct ctacaccact tatcgcaata 2006941 agctctatta cgaagacatc catcatcatc cgtggctgct gcaaaacgcc gaagcagaaa 2007001 tttcagtcaa tacggtgact gatgctcacg gtattacatt gccggagtca gaccccttgc 2007061 ttcattatgc taaaaaacag gatgtgttat tttggccgct taggaaatgg agctaaaaaa 2007121 acccgatgcg ggaaatcgca ctcgggtttt ctttttttat tttgccgcct cttcaataat 2007181 ggcaacaacc atttctgccg ttttaacgag ctcttcgatc ggcatttttt cattttttgt 2007241 atggatttgc tcataaccga cagcaagatt gaccgtcggg atgccatgac cagcgattac 2007301 gttcgcgtcg cttccgccgc cgctcgtttg cagctcgctt ggacgtccga ttttagcagc 2007361 cgcttttttc gcgatttcaa caacttggtc gccgtcttga tatttaaagc ccggatacat 2007421 aacctcaatt tcgacttctg cgcgtccgcc catatcagca gctgcctctt caaaagcagc 2007481 tttcattttt tgaacctgag cttccatttt ctcaggaact aaagagcgcg cttcagcaag 2007541 aatatgaact tcgtcgcaca caatgtttgt ttgtgtgccg ccttcaaacc ggccgatatt 2007601 agctgttgtt tcttcatcga tacggcccaa tggcattttt gagatggctt tgctagcgat 2007661 tgtaatcgct gaaatgcctt tttcaggttc aaccccggcg tgagcggttt tcccgaaaat 2007721 tgccgctctt accttcgcct gtgtcggcgc ggccacaatg atatttccga cttttccgtc 2007781 tgaatcaaga gcatagccgt aggatgcagt gatcatagaa cggtcaagcg ccttcgctcc 2007841 gatcagaccc gattcttccc ctactgtgat gatgaattca atcgtgccgt gttcaatatt 2007901 ttcttctttc agcaccttaa tcgcctcaaa cattgcagcc aatcccgctt tatcatcagc 2007961 acctaaaatc gtcgtgccgt cagttttgac gtaaccgttc tctacaactg gttttacgcc 2008021 gtttccgggt acaactgtgt ccatatgaga tgtaaaatag atcgtatctg tttgttttgt 2008081 cccttttagc gtgcaaatca ggttaccggc tccgtggccc gtgatatcca ttgtatcgtc 2008141 ttctttaacg tccacaccta aatcagaaaa ttttcgtttc agcactttgc agatttcagc 2008201 ttcgtgcttt gtttctgagt caatttggac aagctctaaa aattcttcca gcaggcgttt 2008261 ttcattcacc atttgtaagt ccctccatat taaagcggta tgttaccgtg cttttttttc 2008321 ggtctctctt ctgtcttatg tgtaagcata tgaaaagctt gaatcagtct tccccttgat 2008381 tcttccggca aaatgatgtc atcgaccatt ccacaagcgg ccgctttgta tgggccggcg 2008441 ttttgctttt tgtattcagc agttttttcg cgtttcgtct tttgcgggtc agctgaagct 2008501 ttgatttcct tttcatacaa aatcgatgcc gcaccttctg gacccatcac tgcgatttca 2008561 gcattcggcc atgcaaacac aaggtccgct ccgatcgctt tgctgttcat ggccacatag 2008621 gcgccgccgt acgcttttct aatgatgagt gtgacttttg ggacagtcgc ttcagcataa 2008681 gcaaacaata attttgctcc atgcctgatg attccgttgt gctcttgctg aatacccggc 2008741 agaaaccccg ggacatcttc gacagtcaac agcgggatat caaatgcgtc acaaaaacgg 2008801 atgaaccttg ctgctttatc agcagcgtca atcgtcaggc ttcccgccag atgcttcggc 2008861 tggctcgcca cgatgccgat tgctttttca cccagccttg caaacccaat gacaatgttc 2008921 ttcgcaaaaa atggctgaat ctcaaaaaaa gactgcgggt cagccagctc cctaatcacc 2008981 ttccgaacat cataaggctt tgtcgtatca gcagggacaa gacggtttaa taacggtctg 2009041 gacgcctctt tctctggctt cggctctgtt gtccggccat tcagcggcaa ataagacagt 2009101 agttttctca cccctgtcag aacctccttc tccgtatgcc cggaaaagtg ggcgtttccg 2009161 ctgacggcat tatgtatccc cgctccgcct aagctctccg catcaacctg ttcccctgtc 2009221 actttttcaa tcaccttcgg gccggtaata aacatccggc cagtctgttc agccataaat 2009281 ataaaatctg tgagtgccgg agaatataca gcgcctccag cgcacggccc taaaataacc 2009341 gatatttgcg gaatgactcc ggaatataag acgtttcggt aaaatatgtg accgtatcca 2009401 tctaatgata acacaccctc ttgaattctc gcaccacctg agtcattcag cccgataatc 2009461 ggcgccttat tttttgctgc cagatccatc aaagcgcaga ttttcctggc atgggtttcg 2009521 ccaagcgccc ctccgtacac tgtgaagtct tgcgcaaata cataaactga gcgaccgtca 2009581 attgtgccgt accctgtcac gaccccatcc cctaacatgc gctgttctct tgttaacact 2009641 tgactttcca tgaaggggtg taattcgata aagctgtcct gatctagaag aaatatgatc 2009701 ctttcccgag cagtgagctt gcccttttgc cgctgctgag ccagcttttc ccgtcctccg 2009761 ccttcttctg cctgcttgcg tttcgtgtaa aaatgatcca tgtgctcatt catgctcatt 2009821 gtgttggtct cctttcggtt cacaaagctc tacaagaaca ccgtttgttt cccgagggga 2009881 aataaacgcg atctttttcc cgttcgctcc ctgtcttgga aacctgtcaa tcaattgaac 2009941 atgctgatca gacaatgctt gaagctgttc agataggcag ttgcacaaaa acgcaatatg 2010001 atgcagtccc tgccctttct tctccaaaaa taaatggacg gggctgtcag ctgtcaacgg 2010061 ctctatcagc tcaagtttga cgctaccagc ttgaaaaaaa gcaacattca ccttttgctc 2010121 ttcaaccgtt tcttgatgaa gaaatgcaag ccccaataca ttttcataaa agcttcttgc 2010181 atcttttatc gaaaaaacgg ctatcccgat atggtcaagc ctgttcattt tcatccctgc 2010241 tttcgctaat agatatcgct tgtccgccca ttcaaaacac gctaaaatat agacagattg 2010301 tttaaggagt gaaaatcatg tctcaaaaac tgatgaaaag cgttttgatc gtgattttgg 2010361 gagtttttat tctttcaact gtactctcag gaatcgtcat gtttctataa cgataaaaaa 2010421 gcaggcgcct tattcaatgg gaatatcctg cttttttatc agagctttat gctcgatggc 2010481 aatctcctca aaagagcggt tgtcgtccgt gatcagcact ctcgttccta ctggtatcgt 2010541 ttgaaacaaa tgaacaacct catcgttatg catacgtata cagccgttag acacaaattt 2010601 tcctactgat tcctctcggt ttgtcccatg aattccataa atccgcccgt ccgttccttt 2010661 cgcgtcaaat ccgatccatc ttgccccaag cgggttatca ggagatcccc cttcaatatt 2010721 tttctttctg tagtaaggat tttccgcttt taccgttacc gaaaactctc cttcaggcgt 2010781 caaatcatct gtttttccag tcgccacact atacacgcct tctactttgt tgtcgaggat 2010841 aacagcaagt tcatttgttc gcttgttgac aataacatac ggatcacccg gcagcggatt 2010901 ttcgccgagc ggccaaatcg gtgaaatcat catgaaaatc gaacataaga aaaaacgcat 2010961 aagctcctcc tttttcatta ggttgaccaa tgaaggaaga gctcatgcga atcatccgag 2011021 tgatttttgc gcttttattc ctttaaaata acttttaatc actaaatatt gttccatttc 2011081 gccgagaaga tggaagagag cggccctcgc ttcaaattcc tctctagtcg caggaagcgg 2011141 catctcctca aattcttttc tcatgtcagc aagtcttttc agaaatttgt atgctgtatt 2011201 cccagggtgt atcgcctccc gcaaatcatg aataaattca gcgatcattt ttccctgatc 2011261 taccgtgatg gagatcgatg tcactttagg gagaaggcgt tcgataattt caaattgctt 2011321 ttctctcatt ttaaaataat gataatgcag attttcataa cgcaaaatgt ggttttgcac 2011381 atctcgatat gccaggtttt tagcctccgt aatgagctgg tgcgtttccg gaatttcttt 2011441 tcctgaccaa tcttgctcac cagttaacaa ataccgttcg atttctgcaa aaatgacagc 2011501 aaagttatcc tctatctttt tgcggtaggc aatcagtttc cggtcaagac taggcatata 2011561 caagttcatc aatagagcga cgccgatgcc aaccgtaatc agctgaactt cattccagat 2011621 gaaagtaggc gtaatgccgc cggacatgta taaatgaagg ataataacag aactggtgac 2011681 gataccctcg ttaattttta acagaaccgt tatcggaatg aatatcaaaa gaagcgctcc 2011741 gatcacaaac gggtggtagc caataagctc gaaaaagaga taagaaaaag caattgccag 2011801 acagcatgcc gaaaagcggg cccatgaggc ctgaagcgac cgtttttgtg tgatttgtat 2011861 gcacaaaatg gtgatgattc ctgctgatgc gaagttttgc aaatgcaata actggcttat 2011921 ataaatagcc aaagctgttc caagcgcggt ctttattgtg cggtaaccaa ttttaaacat 2011981 gtcggactcc atttctattt gtttcttcaa taaaaaagaa gaggcggcca gccttcttct 2012041 tttttatatt ctataatatt ttctctaaaa agtcctgcgc tcttttggat tttggcgaca 2012101 taaaaaattc cttcggattg ccgtcttcga caatcattcc ttggtccata aacagcacac 2012161 ggtctgccac ttcttttgcg aagcccattt catgtgtgac aatcaccatg gtcatgccgg 2012221 tttcgaccag ctctttcatc acctgtagca cttctttgac catctctgga tcaagggcgg 2012281 aggtcggctc gtcaaacagc atgatgtccg gattcatcgc aagagccctg gcaatcgcga 2012341 cacgctgttt ttgtccgcca gacaaacggt ttggatagtc atttcgcttt tcaaacaaac 2012401 cgactttgcg gagcaggtcc tcagctttct cctgtgcagc ctgttttgat tcttttttta 2012461 cattgacagg cgcgtacatg atgttttcga gaaccgtttt gtgcggaaag agatgaaaat 2012521 gctgaaaaac catcccgatg ttttcccgga cctttaatgt gttggttttc ggcttcgtaa 2012581 tctctgtgtc ttttattgta atggttccgc cgttaggctt ttccaacagg tttaaacagc 2012641 gtaagaacgt tgatttgcct gagcctgaag gaccgatcac ggcaacaacc tcaccctcag 2012701 cgattgttgt tgaaatgttt tttaatactt cgtgtttccc aaatgatttt gacagctttt 2012761 caaccttaat cattggattt cagcttcctt tctacagcct tgccgataaa cgttaaaatc 2012821 aggacaagca cataataaat caatcccgcg ataatgagcg gctcaaggta attgtaagtg 2012881 gcggcgccag cttgatatgc gcgtctcatg acatcaccaa gcccgatgac ggtgacgatc 2012941 gccgattctt ttgttaacgt aattaattca ttcacaattg caggtgatat atttttgaag 2013001 gcctgcggca gcagcagatc cttcatcatt tttccatacg ggacaccgag tgcaacagca 2013061 gcttcttttt gccctttatc aatggcattg attccggctc tgataatttc cgatacataa 2013121 gcggcggaat tcaaagacaa tgcgacaacc gcagcccaaa actggtcaat ttgaaatccg 2013181 agcagctgag gaaggccaaa atagacaatc ataagctgca gcactaaagg cgtgcctcgg 2013241 aacactgatg tataaaaatc agcgatccag ataaacgggc ggaatgtgct gatcttgcat 2013301 aagcttagca caataccgag tataagtccg ataatagcag atacaacaac aatttttaat 2013361 gtaattgcca agccttctaa tataaaagga atttggggga tcgttgctga aaaatccaaa 2013421 ttcatagcct ttgtctcctt ttcttacagg aaaaaagttt cctattcaat aaaaaggctc 2013481 aacgaaaaag ttgagccgct tttttttact tctcgccagt gaaccatttt ttcttcaatt 2013541 tctcaagctc tccgttatct tccatttcct tgagcgcttt attgaatttg tctgtcagtt 2013601 cactgtcctt tctgaaagca attgctgaac cggcttcttc cgctttcgca tcaggaatca 2013661 caaagccttg caggtcatca tttgatttga aatacccttc tgcaacaatg tcttcaataa 2013721 tcgcggcatc gaagcggtca gatttgattt cctgcaccaa atcagaaatt ctgttgcggt 2013781 cttctgtttt aaaaccatat tccggagaaa gctctttccc cttctcttcc tgaatagagc 2013841 caagctgaac gccaactgtt tttcctttca ggtctttcaa agattgaatg ccgctgtctt 2013901 ttttgctgac aatcatatgg ttcgctgtgt aatacacatc ggaaaaatca acttgttttt 2013961 tacgctcagg cgttggtgtc attcctgaca gaacgagatc cacctgtttt gatttaagcg 2014021 ctgtaattaa gctgttgaag tccatatcct gcacttcaat ttcatagcct gccttctttg 2014081 ccagagcttt tgccagctct acatcaaagc cgacaatatt atctccttct ttatattcaa 2014141 acggtttgta atccgccgaa gtacccataa ttaatttttt ctttccgctt tctgaacctg 2014201 aattgcttga gccgcacgca gttaatgcaa aggtgatgca agcagccaca agtaataaga 2014261 gccatttttt catgatccat ttcccccgta ttcattactt ttggtgtatt tgaatattta 2014321 ttcgttaatt tgtattttaa acagtttctc atttttatgc aatactattt ttaaaaatta 2014381 tctttaggct tatctttcca gtgatctctt ctgatattac tagataaaaa ttaaatcgct 2014441 gtacaatccg attgaataat cccttaatat ttattcatat atccttggaa atttatgcac 2014501 aaaaaaaccc gggctgcttt gagcatccgg gttgttcgtc ttatacttct tcacaatatt 2014561 cttcaaaggc ttcctgcagc tttgccacta cagccatcgg ctcatggcct tcaatttcat 2014621 gacgctctac cattttcatg atctttccgt ctttcaaaat cgcaaaggac ggagaagatg 2014681 gtggataacc ttcaaaatag tcacgcgcac gcgctgtcgc ttctttatcc tgtccggcaa 2014741 aaacggtgac gagctgatca ggtcttttat catagtgaac ggaatggtag gctgccggtc 2014801 ttgcaattcc tccggcgcat ccgcaaacag agtttaccat gacgagcgtc gttccttttt 2014861 tcgtaagtgc ctcatccacc tcttcggctg ttttaagctc ggtgtatccg gcagctgtta 2014921 tttcttgtct cgcttggcgg acaatatcat tcataaataa attaaagtcc atgttcaatg 2014981 aagacctctc ctttttcatc atctgttctt atgatagcaa ggaaacgtcc atatcggcaa 2015041 atgactttgc ttcgccgtgc actttttttg ctcttcgttt actgcttaca gaaaaagggg 2015101 attatataac cagaagtaaa ataaaggagc agttgtatat gagccaccgg aaagcgttac 2015161 tgattcataa cggaaatgcc ggcaacaaaa atatagaaaa agcacttggt gctgtggtgc 2015221 cggttttatc tcaccattta gatgaggtga ttattaaaca gacaaagaaa aaggatgatg 2015281 cgtatcattt ttgccgatcc attgatgatt ctgtcgacac cgtcttcatt ctcggcggcg 2015341 acggcacgat ccatcaatgc ataaatgcta tcagcgctct agaaagaaaa cccgctgtcg 2015401 gaattttgcc cggcggcacg tgcaacgact tttcaagagt gcttggcatc cctcaaaatc 2015461 ttgcaaaggc cgcggaagca cttatggcgg gaaaaaaaac cagcgtagac gtatgtcaga 2015521 tgaatgaccg ttattttttg aatttctggg ggatcggctt aattgcagaa acgtcgaatc 2015581 aaatcaacga aacggaaaaa gcattattgg gaaaaatcag ctattttaca agtgccttgc 2015641 gaaccgtctc atctgctgca tcgtttccga tgacattaaa aattgatgga gaagaaatta 2015701 aagaagaagc cgttatgctg cttgtgatga atggccaata cattggaacg aatcgaattc 2015761 ctctgcccga tgccagtatt gaagacggct tacttgatgt tctcatatgc cgcaatacca 2015821 acctcaccgc gctgcgggag ctgatgagca tggaacaagg ctcaattgat cgttttactg 2015881 gagagttgtc ctatgtccag gcttcccgta tcgagattga aacagacact gccaaaaagg 2015941 cggatatgga tggagaagtt tatacacata cacccgcagt cattcaggtc ctgccacagc 2016001 atatcgacat gcttgttccc gcaaatgaat aactgtcata aggctttaga aagattttgc 2016061 aaatccgttg actctcccct aggaggaggt cttacagtat aagggataca cacttgaaaa 2016121 aggggaagtc atatggagaa gaaaaatatt accttaacta tattattaac caatttattt 2016181 attgcttttt tggggatcgg gcttgtgatt ccagtaacgc cgaccattat gaatgaattg 2016241 catttatcgg ggaccgcggt cggctatatg gttgcctgct tcgctattac acagctcatt 2016301 gtctcaccaa tagccggacg atgggttgat cgcttcgggc gcaagatcat gatcgtaatc 2016361 ggcctgttgt tctttagtgt gtcggagttt ttgttcggca ttggaaaaac agttgagatg 2016421 ttatttatct cccgtatgct gggcggtatc agcgcagcct tcattatgcc cggggtcacg 2016481 gcttttattg cagatatcac gaccattaaa acacggccaa aagcgctcgg ttatatgtca 2016541 gccgctattt caacaggatt tattatcggc cccggcatcg ggggattttt agcagaagtc 2016601 cattcccggc tgcctttttt ctttgcggca gcttttgcac tgttagcagc cattttatca 2016661 atcctcacgc tgcgcgagcc ggaacgaaac cctgaaaatc aggaaataaa aggacagaag 2016721 acaggcttta aacgaatttt tgcccccatg tatttcatag cttttctcat tatcttaatt 2016781 tcgtcttttg gtttagcatc atttgaatct ttatttgcat tattcgtgga tcataaattc 2016841 ggatttacgg ccagcgacat tgccattatg attacaggag gagcgattgt tggcgccatt 2016901 acgcaagtcg tcttattcga ccgcttcaca agatggtttg gcgaaattca tttaattcgg 2016961 tacagcttaa ttctctcgac gagtctggta ttcttgctga caacggtaca ttcatatgtt 2017021 gcgattctgc tggtgacagt caccgtattt gtcggatttg atctcatgcg gcctgcggta 2017081 acgacttacc tgtcaaagat tgcgggaaat gaacaggggt ttgccggcgg tatgaattca 2017141 atgtttacaa gtatcggcaa tgtattcggg cctattatcg gcggaatgct gttcgatata 2017201 gatgtaaact atcctttcta ctttgcaacg gtcaccttag ccatagggat tgcactgacc 2017261 attgcttgga aagcgcctgc acatcttaaa gccagcacgt gataagaagc gcattctttg 2017321 tgtactgcaa agaatgcgct tcttctttat actgatgata gaaggagtga tggcatgaag 2017381 gaatcgtatt actcaattgg ggaagtatca aaactggcaa acgtgtcgat aaaagcgctc 2017441 cgttattacg ataaaattga tttatttaaa ccagcctacg tcgacccgga taccagctac 2017501 cgctattata cagattctca gctcattcat ctggatttga tcaaatcatt gaaatatatc 2017561 ggcacacctt tagaagagat gaaaaaagca caggacttag agatggaaga actgtttgct 2017621 ttttatacag agcaggagag gcaaatcagg gagaaattag actttttatc agccctggag 2017681 caaaccattt cattggtgaa aaagcggatg aaacggcaga tggaatatcc cgcgctcggt 2017741 gaggtgtttg ttttagatga agaagaaata cggatcattc agacagaggc agaaggaatc 2017801 gggcctgaaa acgtgctcaa cgcctcctac agcaaattaa aaaaatttat cgagtcagca 2017861 gatggattta cgaacaatag ctacggcgct actttctctt ttcagcccta caccagcatt 2017921 gatgaaatga cttaccgtca tattttcaca cctgtattga cgaataaaca gatttcatca 2017981 attacgccgg atatggaaat cacaacgatc cctaaaggga ggtatgcgtg tatcgcgtat 2018041 aatttttcgc ctgaacatta ttttctcaac ttacagaagc ttatcaaata tatcgcggac 2018101 cgccaattaa cagttgtcag tgatgtatac gagttaatca taccgattca ttactccccg 2018161 aaaaaacaag aagaatatcg agtcgaaatg aaaatacgga tcgctgaata ataaagcata 2018221 gaaaaagagc attttttgaa acaaaacttc aaaaaatgct ctttttgctt atttagtaaa 2018281 cagatgtctt ctcgtcaatc gattctaaaa tttgtttcac tcgtccgagg aatcgtccgc 2018341 acacgagacc gtcaagcact ctgtgatcta atgacaggca cagattaacc atgtctctga 2018401 cagcaatcat gccattgtcc atgacaaccg ggcgtttgac gatggattct acttgaagaa 2018461 tcgcagcctg agggtagttg ataatgccca tcgactgaac agacccgaac gaacctgtgt 2018521 tgttgacggt aaacgtgcct ccctgcatgt catctgcagt gagttttccg tctcttactt 2018581 ttttagctag gccggtaatg tctttcgcaa tgcctttaat tgttttttca tcagcgtttt 2018641 taatcaccgg aacaaataaa gaatcctctg tggcaactgc aattgaaata ttgatatcct 2018701 ttttctgaat aattttgtcc cccgcccaca tgctattcat ttgcgggaat tcttttaacg 2018761 cctgagcgac cgcttttaca aaaaaggcga agaacgttaa attaaagcct tctgtcttct 2018821 taaaagaatc ttttatactg ttgcgatatg caaccatatt tgtgacgtcg acttccatca 2018881 tcgtccaagc atgcggaatt tctgttttgc ttcgcttcat attggaagca attgcttttc 2018941 ttacacctgt gacagggatt tctttatcac cggctgcaga cgcaggatat gacgtctctt 2019001 cttttggctc aggttttgat gcagacttcg gtgcaggagc tgctgttttc agctcctcag 2019061 gattctgttc ttgcacgccg cctgtttcaa ttaagcgctg aatatctttt cgtgtgatgc 2019121 gcccgccggc accagttcct gtcacttgat cgaggtcaat gccgtgctct ccggccaaac 2019181 ggagaacagc tggcgagtag cgctttttat tgggctgatc ggctgctcca gcactttttg 2019241 caacagggtt ctcagcggct tctgatgctg ctggctgttc ttgtttttgt tcagccggat 2019301 tcgcgccttc tgtttcaatt ttgcaaatca tttctccgac ttgcagggtt tggccttctt 2019361 ctcccacaag ctctgttatc gtaccagtaa aagaagacgg aacctctgca tttaccttat 2019421 ctgtcatgac ttccgcgatc ggatcgtatt tgttcacttt atcaccgggg gcgacaagcc 2019481 atttgctgat cgtcccctct gttacgcttt ctccaagctg cggcatcgtc atttgttcaa 2019541 ttgccatgat tgtatcctcc cttacgtctt taaaactccg ctaattctct catcgccgct 2019601 tccactttat cagggttgac cataaagtat ttttccattg tcggcgcata aggcatagcc 2019661 ggaatatcag gacctgcaag ccgtttgatc ggcgcgtcta agtcgaacag acaatgctcg 2019721 gatataattg cggctacttc gctcatgatg ctgccttctt ttgtatcttc tgtgaccaaa 2019781 agaacctttc cagttttgga cgcagcttcg atgatggctt ctttatcaag cgggtaaact 2019841 gttcttaaat ccaccacatg cgctgaaatg ccatcttttt cgagacgttc tgcagcttgt 2019901 aaggcgaagt ggacacacag gccgtatgtg atcactgtga tgtcgtcgcc ttcccttttt 2019961 acgtccgcct tgccgattgg caggacataa tcatcagccg gaacctcgcc ctttatcaga 2020021 cggtatgccc gcttgtgctc aaaaaacagc acggggtctt cgtcacgaac tgcggctttt 2020081 aagagccctt tcgcgtcata tggtgttgat ggcatgacaa ttttcagtcc gggctggttg 2020141 gcgaaaattg cttcgactga ttgagaatga tacagggctc cgtgcacgcc tccgccgtat 2020201 ggcgctctga cgacaatcgg acagctccag tcattgttgc tgcggtagcg gattttagcc 2020261 gcttcagaaa taatttggtt gactgccggc ataatgaaat cagcaaactg catttcagca 2020321 atcggtctca ttccgtacat tgccgctccg ataccgactc ctgcgattgc agattcagca 2020381 agcggcgtat ccataacgcg ctcttcccca aattgttcat agagtcccgc tgtcgcttta 2020441 aacacaccgc cttttcttcc tacatcttcc ccaaggacga aaacgcgaga atctcgttcc 2020501 atttcttctt tcatcgccaa attgattgca tcaatatatg acattactga catttgttct 2020561 tcctccctac ttcgcataaa cataatcaag cgctgactca ggagctgcat atggggcgtt 2020621 ctccgcttca tccgtcgctt catttacgat tgccataatt tcatccagca tggtttgttc 2020681 tatctcatcg gacagcaggc ctgtttcctt taagtaagct tgataagtaa gcaggggatc 2020741 actttttttc gcttcctcta cttcttcacg gcctctgtag ctgctgtcat cgtcatcact 2020801 ggaatgtggt gtaaggcggt aagaaatcgt ttcaattaat gtcgggcctt ctcctctgcg 2020861 tgccctttcg cgtgcttctt taaccgcttg ataaacttcc agcggatcat ttccattcac 2020921 agttacgcca ggcatcccat agcctatggc acggtcggaa atgttctcac atgcgacttg 2020981 cttatcgtaa ggcactgaga ttgcgtattt gttgttttca cacatgaaaa taaccggcag 2021041 cttatggaca gcggcaaagt ttgccccttc atggaaatcg ccttggtttg aagacccttc 2021101 cccgaatgta acaaaggctg cgatatcctt tttctccata cgtcccgcaa gcgcaatacc 2021161 gactgcgtgc ggcacttgcg ttgtaaccgg agatgatccc gtcacaatgc ggtttttctt 2021221 ttgtccgaaa tgtcccggca tctggcggcc tcctgagttc ggatctgctg cttttgcaaa 2021281 cccggacatc attaagtcct ttgctgtcat gccaaacgcg agcacgacac ccatgtctct 2021341 gtagtacggc aatacataat ccatttcacg gtcaagtgcg aaagccgctc ctacctgtgc 2021401 tgcttcctgt ccttgacaag agattacaaa tggaattttg ccagaacggt ttaacagcca 2021461 cattctttca tcgatttttc ttgctaacag catggttcta tacatatcaa cggcttcctg 2021521 atcagtcagc cctagtgctt gatgtcggtt tgtactcatt caagcccctc ctttatgctt 2021581 ttaaaaatga atggctttgc catctgcggc aagcgcagct tctccaattg cttcagaaag 2021641 cgttggatgc gggtgaatcg tttgcccgac ctcccacggt gttgcgtcca gcactttggc 2021701 aagacccgct tcagaaatca tgtcggtgac atgcgggcca atcatatgaa cgccgagaat 2021761 atcatctgta tctcggtcag ccacgatttt gacaaaaccg tcgctttcac cgtatacaag 2021821 cgcttttcca atcgccataa atgggaactt gccgattttg acattatgcc cgttcgcctt 2021881 tgcttcgtct tcggttaagc cgacactggc agcttcaggg cttgagtaaa tgcacttcgg 2021941 cacaagcgtc ggatcaagcg gatgcggatt gagacctgca aaatgctcaa cagcaataat 2022001 tccctcatgt gaagcaacgt gagctaactg caggccaccg attacgtctc cgattgcata 2022061 aatatgagat tccttcgttt ggcagctttc attgactgaa atcatgccat tttcagtaac 2022121 aatatcggtg ttctctaggc cgatgccttc gatatttgcc tgtctgccga tggaaacaag 2022181 cattttctca gcagaatagg taacggtttc tccgtctttt tccgcttgta tgctgatatc 2022241 gtctgatgtt tttgtcattg tgtcaggcag cacttttgcc cctgttatga actggatgcc 2022301 ttttttctta agaagacttt ccatttcttt tgaaatctct agatcttcag tcggcaatat 2022361 gcgatccgcg tattcaataa ccgttacctt aacgccaaaa tcatgaagca tagacgccca 2022421 ttcgataccg ataacccctc cgccgacaat gatgattgac tgtggcagct cctccatttg 2022481 gagcgcctca tctgaagtca gtacagactt accgtccact tcaagacccg gaagcattct 2022541 cggtcttgat cctgttgcaa tgatcacttg tttcgggatc agcatgtcat tttcttcgcc 2022601 atttccccgc tcaacagaaa ttgttcccgg cagcggagag aagattgacg gtccaaggat 2022661 acgtccatat ccggtgtaca cgtcaatttt tccttttttc attaaatgat ttacacccgc 2022721 tgcaagctta tcaacaacgg cttgcttacg ctgctgcact ttttcaaagt tgagggacac 2022781 gccagccgtt tccactccga attgatcggc ttcacgagct gtccggtata cctctgcgct 2022841 tctaagcagc gctttactcg ggatacagcc tttatgcaga catgttcccc cgagtttttc 2022901 cttttccaca acggctgttt ttaagccgag ctgagcggct ctgatggccg caacataacc 2022961 gccggtaccg ccgcccagaa tgactacgtc atactcagtt gccatggtga ctcactcctg 2023021 tctgtctatt caatacgata ttgtttggat tgctcttcgc cctgcaatac tcttagcgcc 2023081 ccttgggcaa gagactgcag ttcattttca cccggataaa ctaaaacgtc tgaaatccaa 2023141 tctatgtatg atctgatagc agaaacaaag ctttttccgt acgcaaggcc tcccgtcagc 2023201 acaatcgctt caacttcgcc ttttaacgcc gcgctggctg ccccgatttc ctttgctacc 2023261 tgatatgcca tggcatcata aatgaagcgg gctttttcat cgcccccttg aatcatctgt 2023321 tccactttta ctgcatcatt tgtaccgaga tagcctaaaa gtccgccggt gccaacaagc 2023381 tttttcatga tttcttcttt tgtatattcc cctgaaaaac atagatcaac aagatctccc 2023441 gcaggcactg ttcctgctcg ttcaggactg aatggtccct cgccgtgcag gccgttattg 2023501 acatccacca ctcgcccgcg gtcatggacg ccaattgtaa tacctccgcc catatgggta 2023561 ataatcattt tcatgttctc atatcgtttg ccaagggagg ctgccgcttt acgagcgaca 2023621 gctttttggt ttaacgcatg gaaaatgctt ttcctttcaa tttcaggcat gcctgaaact 2023681 ttcgcaagca ctgacatttc gtctacgaca acagggtcga cgatatacga agggatattc 2023741 aggccgtcag cgatttcccg cgcgataatg ccgccgagat tagaagcatg ctgaccggcg 2023801 tagccgcttt tcaaatcctc aatcatctca tcattcacta cgtaggtccc gccttcaatt 2023861 ggccggagaa ggccgcctct tgcgcagact gcatcaaact ttgaaatatt gattccctgt 2023921 tcatgaagcg tttcgagaat atggttttta cgaaattcat actgatcaat aattcggtca 2023981 aatcgctgca gctcttctat gttgtgtctc aatgtttttt caaaaatgct tctttcgtta 2024041 tgaaaaacac cgattttcgt tgaagttgag cctggattaa ttgtgagaat gcgtttttcg 2024101 tcatgtagca ctttcataac ctccagatca atttcttaac gtctgcttaa tacactgtgg 2024161 ccgttttgca aaaactggct tcttgagcgg cgcatgcgtt caatccgttc ctctgctaag 2024221 cggtcagccg ctaaatatgc aggaatgccg tcacgctgag aaatctcaag tacacgctcg 2024281 atattgccgt aaatgccttc aacttttttc aatgcacgtt ctgcattata gccgtaaagc 2024341 tcatctgcca cgttgatgac accgcccgcg ttaatcacgt aatccggtgc ataaacgatg 2024401 cccatttcgt gaatttgatc accatggcgt gtctctttta attggttgtt agccgcacct 2024461 gcgatcactt tcgccttcag ctgtttaatg gtgtcgtcgt taatagtcgc accaagggca 2024521 cacggcgcat aaatatcgca gtcttgtgaa taaatgtcat caggatctac cgcacgggcg 2024581 ccaaaatctt caactgcacg ctgtacagat tgtttgttga tatccgtaac gattaagttt 2024641 gctccttctt catgcaggtg gcggcaaagg ttataggcta cgttcccaac accctgtaca 2024701 gcaatggttt ttccttcaag agagtcggtt ccgaaagcag ctttagctgc tgccttcatt 2024761 cctctgtaca ccccgtacgc tgtgactggg gacggatttc cagaagagcc gaaagcagga 2024821 gaaatccctg tgacatagtc tgtctcatca tgaatgatat ccatatcctc gaccgttgtg 2024881 cccacatctt cagccgtgat gtatctgcca ttcagtcctt gaatatagcg gccaaacgcg 2024941 cggaacattt cctcattttt gtctttgcgc ggatcgccga taatgactgt ttttccgccg 2025001 ccaaggttta agcctgccgc cgcgttctta taggtcatgc ctcttgccaa tctgagcgca 2025061 tcttcaattg ccgcttcttc attttcatat gtccacattc tcgttccgcc aagcgccgga 2025121 ccaagcgttg tatcatgaat ggcgataatc gcttttaatc cagattgttc atcctggcag 2025181 aataccaatt gttcgtaatc gtatttctcc atatatttaa aaagttccat gttcgttcct 2025241 cctaatgtgt gtattcttca gatgcgcata ttgccagcgc aatggaatac agtttatttt 2025301 cagcagagtc cgctctgctt gttaaagcaa tcggtgcttt tgctcctgta atgacagccg 2025361 ccacgctggc cttggcaaaa taaatcagtg atttatataa aatattgccg gcctcaattg 2025421 ttgggacgag aaggatatct gcgttgcccg ctacgtctcc cgaaattttt ttctgggccg 2025481 cggcaatttg tgaaactgcg ttatccaaag caagcggtcc atcaacaatg cagcctttga 2025541 tctggcccct tttgtacatt tgagctagag cagctgcatt cacggtcgct tccattttag 2025601 ggttcaccgt ttcgaccgct gcaagggcag ctgcttttgg catattgttc cccactgcat 2025661 gggccacatg aacggcattt tgcaaaatct gccggagctc ttccagcgaa ggagcaatat 2025721 tcattgccga atctgtcaca aacatcagcc ggtcaaaatc cggtatatcg aagacagcca 2025781 cgtgagaaag gacacttgct gaccgaagcc cctcctgtct gttcaatacc gctttaagca 2025841 aaacagaagt cggcacattg cctttcatta aaacgtccgc tgttttatga tgcacagcac 2025901 gaaccgctaa tttcgccgat tcctcaggag tattggcatg gacgatttcc acttgatgcc 2025961 cttgcatgga tgatgtcagc tcgttcagtt ttttgctgtc gcccgttaac aagaaacggg 2026021 cggataggtg ctcggctgcc agctttacag cccggatcac ttcctcatcc tcagcatgag 2026081 caaccgcaat ggtcttattt ttgtgtatcg acgctttgcc gattaaatct ttcagcttca 2026141 tctgttacca cctttcttgt ttcgactccg ccttttatta tgcaagttcc atgccagctc 2026201 ttaagggtgc tgtcatacca ggtataccga aacattcgtg cagatgtttg cgtttattct 2026261 gcaaattatt gcatgccttc atttgcaagg ccatatttat ccattttgta atataaattc 2026321 cgaatgctga caccgagagc ttttgctgtt tttgtccggt taaaatgatg cttttcaagc 2026381 gtttgctgga tcaaatgcgc ttcaaatttt tctactgcga cagacagctt ttcgccttca 2026441 atatccggaa aatcaaaacc tgttccctga tctgtgtcat tttctttttg ctcaagttcg 2026501 aatacaggca agtgatcttt ttcaatccat tccatatgcg gattcagaaa aatcatggct 2026561 cgtccaagga cattttcaag ctcccggaca ttcccaggcc aatggtaggc agataaggcg 2026621 cgcaaggctt gctgtgagag cccttttaca ttcctgccgt aatcccggtt gatcttttgg 2026681 ataagtctga cgctcaatgc ttcaatgtcc tccaaccgct gccgcaaagg cgggatggag 2026741 atcggatagc gattgatccg gtaatacagg tcttcccgga atgttccgtc cgccatcgcc 2026801 ttttcaatat ttacatttgt cgccgcgatc actctgacgt tgacagggat cgctttcgtg 2026861 ccgcccactc tgacgatttc cttttcttga aggacgcgta gcaatttggc ctgcatattt 2026921 tgtgtcagct caccgatttc atctaagaaa atactgccgt tatttgcttc ctcaaataaa 2026981 ccctttttac cgccgcgctt cgctcctgaa aacgcaccat cctcatagcc gaacaattct 2027041 gattcgagca ggttttcaga aagggctgca caattcacgc gaataaattt attgtatttc 2027101 cggtcacttt cgttatggat ggcatgggcg aacagttctt ttcctgttcc tgattccccg 2027161 cgcagcaaga tggttgccgg tgttttcgca ccgagcttcg cctgctcaag cgcaaccagc 2027221 atttgctcgc ttttgccgat aatgtcgtca aacgtgtatt tcgcttcaag cgtgcgaata 2027281 atttgtctgg cgcgattaag ctccgctgtc agcattttaa tttcggaaac atcgtgaatc 2027341 acgccgacgc tgcctttcaa aatcccgtcc acaatcaccg gtgctacatt aacgatcact 2027401 tctttttcat tcgggccgac cttcattctg acaccgcgga caggacgtct tgtttcaagc 2027461 acctttaaat gcatgctttc gccttcggaa atatcagtgt ttgcaggctt gccgatgact 2027521 tctttttcag aaagccccgt cattttcgta tacgctttat tgattagcag gccgatgccg 2027581 ttttcatcaa cgacagaaat cgcctcatcg gaggattgaa taattgcctc cagcatcgta 2027641 cggacctgct ttaagttggt cacttcctct gccagctcga ccgcatcagt gatatcttta 2027701 aacacacaaa gagccccgag cagacgtccg ccttcatcaa taatcggcag tcttgtggtc 2027761 acaatttgca aatgatcgcc taacagctgc ttctggttgt attcaggcac tcttgttttt 2027821 aaaatccgcg gcatcttagt gctcggaatc acttctttta ttgggcgccc aatgacttcc 2027881 tcacgttttt ttccgaccat tttttcggcc atatggttaa agagaatgat ttcttcattg 2027941 atatcaataa aaatcattcc atcatgggtg gaattaaaaa ttctgtcata tttataggtt 2028001 tgctctttta gcatttgaat caggtgctgc ttttcttcca tcagctgaaa aacgatgtat 2028061 gccatttttc ccggcatgac aatggtatct tcatgctttc tttgaaggag ctcgtcaaac 2028121 acggcttgat cgccggtagt atgaatgacg atatccggtt tttgttgtat gtaaggtttc 2028181 caatcagatg atacggcaat cccatactgt tctgcttctt tcaatcccgg cgcctcgggg 2028241 tctttgtcaa ctacggcaat gatatctatg atggctgttt taatcagaat atgtaataac 2028301 gccgttcccc ttttgccggc acctactatc agtacctttt gcatcccgat acccctttgt 2028361 atgaaaaaat ttgcacacct atttattccg ttgcaataat ttgcacaacc ctatgttacc 2028421 acgttttctt ctcttgacaa aatatttttt ccgctggaca ataaaggaaa tgaaaagata 2028481 aaggggtttt ctgaagatga gccgacttct tgcgctttta atattagtca tccccggggc 2028541 tatttctgct ttaggcatta aactgatgag agatacactt ttcggccata caatcaagcc 2028601 attttcagct ctttggctcc aagggttgtc aggattcatc ttttttgcga tcggcctcta 2028661 tgtgctggcc gggttcattt tatacagaga cagaaaacgc aatcaagtca gcccgcgatt 2028721 cagaaaacga tagctgaaaa aaagccggag aatgctccgg ctttttttgt tgcattattc 2028781 gtcaggcaaa acggtcttgg caatcgtttt gtctaacgct tcatagtcat aataagaaat 2028841 cgtatcgtac agttcttttc gtgtctgcat atcatgaagt ccttcttttt gtgagccgtg 2028901 ctccttcatc aaaccaaaca tccgctcaca agcttttgcc gccgctcgaa gcgaggtgac 2028961 aggatatatc accatgtgaa accccatatc ttcgaattca tcggcacgat aatatggcgt 2029021 tttcccaaat tcagtcatat tcgcaaggag cggaacgggg atacgctcag caaactggcg 2029081 gaattcattc tccgcctgta gcgcttccgg gaaaattgcg tccgctcccg cctcaatgta 2029141 agcctctgaa cgttttattg cggcatcaag cccttcctgc gccctggcat cagtacgggc 2029201 aacaacaata agggagggtg ccgcttgttt aatggctttt attttttgcg ccatttcctt 2029261 tatcggaact agctgtttgc catttaaatg tccgcatttt tttgggagct gctggtcttc 2029321 catttgaacg gctgctaccc tggcttcaag catctcccgg gctgttcggg cggcatttaa 2029381 gacaccgcca aatcccgtat cgatatccac aagcaaaggc agatcagctg cacgcacaag 2029441 atctttggcc cgttcagcta tctctgccga tgtgatgatc cctaaatcag gcagccccct 2029501 gctggctgta taggcagcac cggacaaata aatagcagaa aaaccggctt ctttcgcaag 2029561 caaagcggcc atcccgtcat gggcgccggg aatttgaaga atgtccggtg ctgacatcag 2029621 cttgcggaaa cgcccggcaa gctcctcttg tgacgattgc ttattgacga tccacgacat 2029681 gaaacaaaat ccccctttta catgcagaac atgtctacga attcatttac gcgcatcgtt 2029741 tgtaatgtct catagctggt acagcgctca taaatgtgtt tgtgctgttt atcaggaaaa 2029801 tgggttttga gattgtcaga aaacttttcc agcagtttcg gcactgcttc ctctcttcga 2029861 aaacgatggc cgaggggaaa ctcacattcc accatttccg tgctcgttcc atctttaaaa 2029921 tgaacctgaa cggcatttga gatggagcgt ttatcaggct tcaaataatc ctcggtatat 2029981 gttttatttt cagtcacttc cattttatca cgaagtttat ctattctcgg atcattcgct 2030041 gtttcagctt cataatgctg tgcggtgata tcaccaaaaa gcaaaccgat tgctgtaatg 2030101 tattggaggc agtgatcacg gtctgccgga ttgtggagcg ggcctttttt atcaatgatt 2030161 cggatagctg attcatgcgt tctgatgaca actcggtcaa tctcgtcaat ccggttcttt 2030221 acctgcgggt gaagaatgac ggcggactcc gccgctgtct gggcgtgaaa ttccgcagga 2030281 taagacactt taaataacac attttccatg acataagcgt cgagcggacg ggcaagcttg 2030341 atctctttct tattgaataa aacgtcttgg aacccccaac ccggtgcact caaggctgtc 2030401 ggataaccca tttccccttt taacgacatc agcgccaaat gaacacctct gctcgttgca 2030461 tctcctgccg cccatgattt acgcgagcct gtattcggtg aatggcggta tgtcctcaat 2030521 gctgcattgt caatccatgc attcgaaagc gcatttttga tttcttctct tccgccgccc 2030581 aaaagctttg ctgcaacagc agttgtcgca actttgacaa acagcacatg gtcaaggcca 2030641 actcgattta agctgttttc taacgccagc acaccttgga tctcgtgtgc tttgatcatc 2030701 atctcaagta cgtcgcgtac cgttaacggc tcttttcctt cagacagcct cactcttgat 2030761 acataatcag cagcggcaag gattcctccc aagttatcgg atggatgccc ccactccgcc 2030821 gccagccacg tatcgttgta atcgagccag cgaatcatgc agccaatatt aaacgctgcc 2030881 ctcacaggat cgagaacata tgacgttccc ggcactttgc ttccattcgg cacagtcgtt 2030941 cctggaacaa tcgggccaag cagctttgtg cattccggat accgtagcgc caagattccg 2031001 cagcccaggg tatccagcaa tacatgcccc gctgttgtat acgcttcggc actagtaatc 2031061 tctttctcaa gcacatagtc tgtgatttct tcgataacac gatccgtttt cggcattcta 2031121 ccagctcctt tcatgatttt gtttgatatc gcgggcccat gtaactgaca cggggacgga 2031181 agagccgatt attggcatgc tgttcgatca catgggcgca taaaccggac gttctcgcgc 2031241 tgaaaaagat cggcgtatat aaaggaatcg gtatgccgag catccaatac actggggcag 2031301 catagtaatc caaattcggg taaagccctt tttccttctc catcagccgc tcacccgctt 2031361 cgcacatctc atataaacga tggtcaccgg ctttatcgca taattgctgc agcgcctctt 2031421 tcatcatgag tgctctcggg tccatttttt tcatatacac ccggtggccg aagcccatga 2031481 ttttttcttt tcttttcagt tttgtttgca aaagctgctc aaaatcagat gtcgtttttg 2031541 cctccaaaag caaatacatc acagcttcgt ttgctcctcc gtgaagattc cctttcaggg 2031601 aagcgacagc cccagtcaaa gccccataaa gatctgaatg tgtagatgca atgaccctgg 2031661 ccgcaaaggt tgaattcggc atctcatgct cactgtacag gacgagcgac cggtcaaaaa 2031721 tctgttcttc caatgaagac ggcaatttcc ctgtcatcat gtagagaaaa ttcgcactgt 2031781 aggatagggt ttgaagcgga agaatcggtt ctttcttatt aatgatcctg tagctggcag 2031841 cagtgagggc aggcattttc ccaagaagct gataggcgcg ttctttgttt gcggaaggag 2031901 accgatcatc aatttgccga tcatagccag caagtgccga caggccggta cgcagaccat 2031961 ccattggatg agtgtcctca gggagcagct caagcagacg gagatgatca gcaggcaggc 2032021 ttgaggcact gtttatttta cgttccagcg tttccatttc actttcttct ggcagcctgc 2032081 cctccagcaa taaatggaca agctccagat agctttttgt ttcagaaagt tctattaaat 2032141 catagcctct tatcaaaatc tggctggact gcgtgtcaag ataagaaata tgagtttctg 2032201 ccgcaatcac accgtccaac cctggagaat aatgctgttt ctcctccata tcctcaacct 2032261 ccgtttttgc gttttttgtc tatcaggttc cgccaagcaa atacttggaa ataatcagtc 2032321 tttgaatctc gttcgtccct tcataaattt gcgtcacctt tgcatcgcga agcaggcgct 2032381 caactggata atccttcata tagccatatc ccccataaat ttgaacggcg tctaacgccg 2032441 cctttacggc tgcatcggaa gcaaattgtt tagccataga cgcttctttt ccacagttta 2032501 ggccgcggtt atgaaggtct gcagcgtggt agacaagatg tcttgccgcc tcagctctag 2032561 tcgccatatc agccagctta aatgatatgc cttgattggc tgcaatcggc cttccaaatt 2032621 gcactcgctg cttcgcataa tcaacggcat gctcaagagc cgcctctgca attccgaggg 2032681 cctgtgccgc aatgccgatc cggccgacat ttaaattcgc catggcaatg tgaaagccat 2032741 ccccctcttt gccaagcaaa ttggcttcag gcacttctgc attatcaaaa atcagttccg 2032801 tagtattgga gccataaagc cccagctttc tttctttttt tccaacggta aaaccgggtg 2032861 tgtttttttc aacaataaaa gccgaaatcc cgtgcctgcc ttgatctgga gctgttaaag 2032921 caaatgtgat atagatatca gctgctccgc cattcgttat gaatattttc gatccgttta 2032981 ataggtattt gccgttcttt ttgattgctg ttgtgcggag gctcccggca tccgaccccg 2033041 agtgaggctc cgttagtgca aatgcgccca aatggtctcc tgacgcgaga tttggtatat 2033101 atttcatctt ctgttcttcg ttgccgaaat acagaatcgg attcgtgccg actgaggtat 2033161 gaacggagag aatcacgccg acagccgcgc tgattctaga aatctcatga attgccaaaa 2033221 tataagaaac aacgtccgct ccagcaccgc cgtattgttc cggcaccggt attcccatca 2033281 gtccgtgttt acccattttt ttgatcagct gaaagggaaa ttcgtccgtt ttctccatga 2033341 tttccgcagc gggagcaatt tcttttcgtg caaaatcacg caccattttt cgcatcatga 2033401 cttgctcttg ggttacatgc aactcggcca cccccggatg gaatagactt caggaagtct 2033461 tctcctcata gtcataaaaa ccgcgtccgc tctttttgcc aagccagcct gctttgacat 2033521 acttgcggag cagcgggcaa ggacggtatt tggaatcgcc aaggcctgag tgaaggactt 2033581 ccataattga taaacacgta tccagtccga taaaatccgc taatgcaagc ggacccatcg 2033641 gatgattcat gcccagcttc atcacttcat ctattgcctc cggcttcgcc actccctcat 2033701 acacgcaata gatggcttca ttaatcattg gaagaagcac acggttggaa acaaacccag 2033761 gaaaatcatt gacttctacc gctgttttcc ccatcttttc cgctaatgcc ataacatcta 2033821 aggccgtttc ttctgatgta gccaagcctc gaatcacttc taccagcttc attacaggga 2033881 cgggattcat aaaatgcatg ccaataaccc gttgaggccg gtttgttaca gcagcgattt 2033941 ctgtaatagg caaggaagat gtattgctgg ccaaaatcgt atgaggcggg caaatgcgat 2034001 caagtgtttt aaacatctca gtttttgccg ccatgttttc tgcgatagcc tcaatcacaa 2034061 tgtccgcatg ctctgcctcc tcaagtgttt gagaaatcga aatgcggttg attacgctct 2034121 tcacttccgt ctcggtcctt tttcctttct cagcatcacg ggccagctgt ttcttcagcc 2034181 gtttcaatcc tgcctccgcg gcctctggat tcacatcata catccgcaca taaaagcccg 2034241 cgtcggcggc tgtttgagca attccgctcc ccatctgacc tgcgccagct accatgattt 2034301 gtttgatttc cattcaaatc ccctttttca tcatgtttta atgaacctgc actaagacgg 2034361 cgtctccctg tgctgccccg ctgcaaatag cggcaacgcc cagaccccct ccccgtcgct 2034421 ttaattcata aacaagcgtc atgagaattc tcgcaccgct cgcgccgatc gggtggccga 2034481 gcgcgatcgc accgccattc acatttactt tttcaagatc gaaacctacg attttttcac 2034541 atgtcaaaac aactgaagca aaagcttcat ttacttcaaa caagtcaata tcttggacag 2034601 ttaaaccatt ctttttcagg agcttgttaa tagcaaaccc tggcgctgcc gccagctcgt 2034661 gcgctggcat tcccgtagtt gaaaaaccaa gaattgtagc cagaggccgt ttgccaagct 2034721 cagcagcttt ttcctcagac atcagcacga acgcgccggc tccgtcattg actccaggag 2034781 cattgccggc tgtgatagaa ccgtcacttg cataaatcgg agcaagtttt gcgagctgat 2034841 ccagacttgt gtcacggcga atcgcttcat ctttatcaac aacgtttggt tttccttttc 2034901 gaccgatcca gttgacggga acaatttcat cctgaaactt cccttcatcg gcggccttag 2034961 ctgcccttgc atgacttctc aacgcccatt cgtcctgctc tcttcgtgag attgcatatt 2035021 ccttggcagc tgtatttccg tgaacagcca tgtgcacctc gtcaaatgcg cacgttaatc 2035081 cgtcatacac cattaagtcc ctaagctcgc cgtcccccat ccgtgctccc cagcgcccgg 2035141 cgggaacggc atacggaata ttgctcatgc tttccatccc ccccgcaaca agtatgtccg 2035201 catcctgcgc ccgaatcatt tgatcacata aagtgacagc gcgaaggccg gaagcacaga 2035261 ctttattcag tgtttctgac ggcacactcc aaggcattcc cgccagacgg gcagcttgac 2035321 gggaaggtat ctgccctgag ccggcctgga caaccatgcc catgacgttt ccttctacat 2035381 catctccaga gactccagcc tgttgcagcg cctccttcat cacaatgccc ccaagctcag 2035441 cagctttcac ctctttcaaa actccgccga atttgccaaa tggagttctt gcagcactta 2035501 caatgactgt tttcctcatg gtttcacctc attcagaaga tagacagcgc ttacaatttc 2035561 tagttgtctt ctatgaatgt atgctttgaa acgggcatga atgaatgaaa aaagaaggct 2035621 gcgtcaaaca gcctccttct aacaactatt catttttcag caatgccgaa gccttttctg 2035681 gaaagtcggt aaacatgccg tctgctcccg cttcaatgag acgcttcata tcttccggac 2035741 gattgactgt atacggcctt accttaatca aaccgttcct cattttcttc agtacttcat 2035801 ctgtgacccc tgggctgttt atcttcgggt gatagccgga agccggaata gacgcgatat 2035861 atcgatctgc ctgataaagc acatctgaag ttaatactgc ccgttcgata tgcggtgcaa 2035921 gccgggcgca cagcgccaag ctgtcatgat taaacgtgga taggatgact ctgtcctcta 2035981 cattaaatcg cttcactgcc tccagcactt tttcttccat tccctcatag cggatcacgc 2036041 tgttttttaa ttcaatgttg atgagaaaat ccttttttac cgcccacgag agcacatctt 2036101 ctagcagcgg cacttttata tcgctgtacg cttgatcgtg accagcggcc gcattcgcag 2036161 tctttacctc atcataggct gtatccttca cgaatccttt aagtgatgtc gtgcgattaa 2036221 gtctttcatc atgaattaca acaatgcgtc cgtctttcgt cagctgtaca tcaagctcta 2036281 tcccatccgc tccggcttca attccttttt caaatgcaag cattgtattt tcgggaaatt 2036341 gacctgatgc cccccggtgg gcaaaaatct ttgtcatcgt ttcacctcaa accctaaagt 2036401 tttctccatt atacttattt tgtcggctcc actctaggat taaggctgta tcaatctact 2036461 gatcataata agaatcaatg ccattgacaa tcgcatctgc ggccttttgc tggtattctt 2036521 cacttcccag cttgtccgcg tcagagctgt tcgtgataaa cccaagctcc gccaacacac 2036581 ttggcatttg tgaatatgta atgacgtaaa agtctgattc tttcacgccc ctgtctctcg 2036641 tttgtaagga agaaacgagc tgtgactgaa tatcggatgc cagacgccgg ctgttctccc 2036701 cttcataatc agattgaaaa tacgtttctg ttcctgaagc tgaagcaacc cctgaattca 2036761 catgaatgct gacaaaaagg tcagcctgat tggcacttgc cttagccact ctttcctcca 2036821 aggtcagaaa atgatcgtca gaccgggatg caacaggatt ggctccctcc tcttttagtt 2036881 tgtctgtcac atgctctgag acagccaaat taatatcctt ttcaaagagc ccgtttccga 2036941 ccgctccact gtcttcaccg ccgtgtccgg catcaatata cactgttttc ccttctatcg 2037001 gctctgctgc ctgtgcacaa ggcgcgagcg tcaaagccaa tccgcacagc gccaagctcc 2037061 tccataacat tctcaactta ctccctccgg tcacgagttc tttcgcagct gaatatcttc 2037121 cagctgtaaa gttccattat ccttctttgt atatttcacc aggacatgtg tctgatctgg 2037181 cagtgattca cattcatcac gtttatcctt cggaacttgt atcatggttt cttctccatt 2037241 aagagaaacc gcaatcgtat gaggatcagc cgagccaatg tattttccct cttcggtaaa 2037301 cctcggcact gagtcatccg cacttgcaac actgcacccc gaaagaaaga gcgcagtaaa 2037361 cagcaaaaga accgtttgtt tcacatgacc acctcttcct gatgtttggc ttttatcttt 2037421 gaccagaatg gagaatttgt aaagacaacg cgaatgcagg cgagcaagtt ccatgatttt 2037481 caaaagggct atacgacccg atcatttcct gttgttagaa agataacgag cagatttgtc 2037541 tatgaggatg gctctaattg aggcgccaat tagaaaaaat tagcggaaag aagcaacttt 2037601 ttattcattt taaaaaattt gagaataggg tgagcaaatc gtttgacggg tgggtcagcc 2037661 aagcgtaacc ttttaaagga tatttacttt attgaaagaa gttaaagcca tgaaaaaatt 2037721 cgttctgctg ctggcggcag ctgtcatcac atgctccatc ggccaccaaa tcagtggcgg 2037781 ctacaaaggc cccgaaaaag agcggccaaa acatcactct gcactcaaga tattcagtcg 2037841 gtaaagcaga tcaattgcat taatttttac atataggcta gaatatgtgc gaatccaaac 2037901 gaaagaagat gatcaaatga atcctaagta taagccactt tttgaaccat ttacgtttaa 2037961 aagcggcgtt acaatcaaca accggatcgc agtagcaccg atgactcatt acgcttctaa 2038021 tgaagacggt acaatatctg aagcggagct cgactacatc atcccccgtt caaaagagat 2038081 gggaatggtg attacagcct gcgcaaatgt tacaccggac ggaaaagcat tccccgggca 2038141 gccggccatc catgacgatt ccaacattcc aggtttaaaa aagttagcac aagccattca 2038201 ggcacaaggc gctaaagctg ttgtacaaat tcatcacggc ggtattgagt gcccgtctga 2038261 gctcgttcct caacaggatg ttgtggggcc aagtgacgtg tttgataacg gcaaacaaat 2038321 tgctcgcgca ttaacagaag aagaagtgga aaacattgtg aaggcgtttg gagaagcgac 2038381 aagacgcgcc attgaagccg gctttgacgg tgtcgaaatt cacggtgcaa acggctactt 2038441 aattcagcag ttttattctc cgaaaaccaa ccagcgcacg gatcgctggg gaggaagcga 2038501 tgaaaaacga ttagccttcc cgctcgctat tgtcgatgaa gtgaaaaaag ccgcttcaga 2038561 acatgcgaag ggtgcattct tagtcggcta ccgcctgtct ccggaagaac ctgagacacc 2038621 gggattgaca atgactgaaa cttatacgct tgttgatgct ttaggggata aagaattgga 2038681 ttatcttcat atctcactga tggacgtgaa ctcaaaagcg cgccgcggtg cagatccgac 2038741 tcgcacacgc atggacttat tgaatgaacg tgtcggaaac aaagtgccgc tgatcgccgt 2038801 cggttccatc cattccgctg atgacgcgct tgccgtcatc gaaaacggta ttccactggt 2038861 cgctatggga cgcgaaattc tagttgaccc taactggacg gtaaaagtaa aagaaggccg 2038921 tgaaaagcaa atcgaaacag tgatcaaagg cacagataaa gaaaaatatc atttgcctga 2038981 accgctatgg caagcaattg tgaacacaca aggctgggtg ccttataaag attaatgtgc 2039041 aaagactgcc gaaacgattc ggcagtcttt tttcccttta tataaatagt ttgtgtacac 2039101 atctaaacag caaaagaaag agctccccac caacttcgaa aagaaaatcc aggaaaaacc 2039161 cctcacgctt tcttgctttt ttctttttca ttcgtacgtc tcctttttac atgaatacgc 2039221 cttacttacg attttgcagg agaaaggttt cattttataa cggacacatc tagggtcgat 2039281 catgcttcgt gatcctataa gatgtatgaa tggaccaaga gtgcaggtaa taccgccatt 2039341 tgctttcctt acttttcaaa cctatccttt actatatgcg gatacttaat attcttctcc 2039401 catactacaa atgtccccaa aacaaaacgc ctcctattta tcagcgcaaa ctaataaata 2039461 aaagacgttt gatttaatga ccacttaata agctcatgtt taagaagcct tatgctctaa 2039521 cctcagctta tccgcaacca ttgcaatgaa ttcactgttg gtaggtttag cttttgtcat 2039581 gctgacagta taaccaaaca acgaggaaat ggaatcaatg tttcctctgc tccatgccac 2039641 ttcaattgca tggcggatcg ctctttctac acggcttgcg gttgtgttaa attttttggc 2039701 gatgtccgga tagaggactt ttgtaatgct gccgagcaat tcgatgtcat tgtataccat 2039761 tgagattgct tcgcgcagat agagatagcc tttaatatgg gctgggacgc cgatttcatg 2039821 gataatgctt gtgatgctcg cgtcgagatt tttcttcttt ggttcaggct ggctgctgcg 2039881 tataatactg ctttgcgatg atggcgcacg atgcgtcaca ctgctggcat ttccgctgac 2039941 ctggcggata tggccgacaa ggttttccat atcaaacggt ttgagaataa agtaggacgc 2040001 gcctaaatcg acggcctttt tcgtgacatc ttcctgccca aaggctgtca gcataatgac 2040061 attcggctgt tttttcagat ctgattccct cagcctctct aaaaccgcaa gtccgtctag 2040121 atgcggcata ataatatcta atacgagcac atcgggatct ttttctttaa acagcgacag 2040181 gcattcctgt ccgttataag caacgccgat cacttccatg tcttcctgtc cttctatata 2040241 ttcacttaac aggcttacca gctctcgatt atcatcagca acacaaactt taattttctc 2040301 cacgtttctt cctccccaaa tgtagttaac aggattcacc cttgctacat gtttacattc 2040361 gacaaaaccg ctatataccc tctaaaaaaa tcataatcac caatattagt ggcatatctt 2040421 tgttattcta tgtttttctc tgtttttcga ctaaaaatga aatttgacaa acaaggaaac 2040481 gtgaatttgt cgaaaaatct tcttttgtat attttaccgt atgtattctg agaagtgaag 2040541 agggatcagg atatactgat gaacgaatgg atgtgcacga aaaaaataag ctgcgcttct 2040601 cgcgcagctt acccagttgt tttgacttga tccgcttgtt ttaaaagttc tttcgcatgg 2040661 cgtttcgtta agtcggttac ttcgacacct gcaatcatgc gcccgatttc cgctaccttt 2040721 tcctgcttag agagcggctt gacacgtgtc gtcgttctgc cgtcttttaa ctccttcgca 2040781 atataaagat gcgtatcggc catggcagcc acctgaggca ggtgtgtaat gcacagcact 2040841 tgtgatccta ttgacacctt atggatcttc tcagcaattg cctgtgcgac cctgccgctt 2040901 acaccggtat caacctcgtc aaaaatgatc gatgtcacat cctgttgtga ggaaaaaatg 2040961 ctttttatgg caagcatcac ccgtgacagc tctccacctg aagcgacttt cgaaagggat 2041021 ttcagcggct cgcctgtatt ggttgaaatt aaaaacttca ccaggtcaat cccttgttca 2041081 gtcagctgaa cgggctggcc gtttacaagc ggcgcctctt cattgcgtga cgctgttctg 2041141 accttaaatt ccgtatcaaa agttgatttt tccatgtaca ggctttttaa ttcccgatga 2041201 atctcatcag ccagcttttt cgcccatgtt tttcggattt gtgacacatt tgccgcttcc 2041261 actgcgacat ctttgccgac ggagtcaagc tcctttttca agctttgaag gtggctgtcc 2041321 ctgttttcaa tttggtcaat ctcttcttca attttagaag catattccaa aatgtcttca 2041381 acagtggcac cgtattttcg tttcagctgt ttgatttcat taagtcgcgt ctcaatatag 2041441 ttcaggcgtt ccggatcaaa ttcaagctca tccagcatat ttctcatctg aaatgtggca 2041501 tcctcaagca aatagtagga gttcgaaaca ctttcagaca tttttttcag cggttcgttt 2041561 atatcagata tatcttcaag ctgcgctgat gccattccaa cccagtccaa tccgccctgc 2041621 tcactgcgaa gcgcgttata tgcattttgc agcgactcat atatcttctc aaagtttgaa 2041681 atttgctggc gctcttcttg gagctgttca tcttcgttaa gctcaagctt tgccgattcg 2041741 atttcttcga gctgaaattg aataagatca agacgatggg ccatttcctg ttcgctttca 2041801 gaaagctgct taagcttttt gagcagcttc acataccgct ggtacccttc ctgatacgtt 2041861 ttgagcgcgc tttccacttc ggccccggca aacttgtcca aaagctggag atgattttcg 2041921 tcttccatta acagctggtt atcgtgctgc ccgtgaatat ctaataaaag cctgccgatc 2041981 tctcttagtg aagcaatcgt gacaagcttg ccattgacac ggcaaacgct tttcccgctc 2042041 gtgctgatat cccttctcat gacgatcatt tcgtctgaaa cgtcgattcc ctgctcagcg 2042101 catacgccta aaacaggatg gccgctctcc aacagaaaca gcccttcaag ttcggctttt 2042161 gcttccccat atctaacaaa ttcagatgat ccgcggcctc cgactaaaag agaaatggca 2042221 tctatgatga tggatttgcc ggctccggtt tctcctgtta aaaccgtaag cccgcgttca 2042281 aaagaaaccg tcagttcctc aataatggca aagtttttaa tcgatagttc agctaacaaa 2042341 cagcattaca cctcttatct ttgttagatt ttctgttaca gcagttcaag gagcctgttt 2042401 tttacgcctt ctgtatcttc aggagtccgg caaataatta aaatcgtatc atctccgcaa 2042461 atggtcccca tcatttcatc ccagtccaaa ttgtccatca gcgccccgat tgcctgggca 2042521 ttgcccggca tcgttttcag cacaatcata tggcttgctg agtctatttt cacaaatgcg 2042581 tccatcaatg cccgctttag ctttgacagc ggattgaaac gctggtccgc cggaagactg 2042641 tatttgtaag aaccattatt tgtaggcact tttacaaggt gaagttcttt aatatcccgt 2042701 gataccgtgg cctgcgttac tttgtatcca tcctgcttta gcatgtcgac caattcatcc 2042761 tgcgtttcga tttcattgct tgtaatgatc tctctgattt taatatgcct ctggcctttg 2042821 ttcatgtaag cacctctatt tccaagctta tctgttcttt tatgttatat gattctctgc 2042881 acattgtaca tgaatgcaga aaaaaggaat aatagcgccc tattattccg gtacatctgc 2042941 ttttttttct tttaacgtct tatgtgcttc ttctacaacg cgcatgatct cttcttccgg 2043001 cagttcctgg ccttcctgtc cctctcccgg ccaatgcaaa tgaaggagaa actcaatatt 2043061 tccgtctcct cccgtgattg gagaaaatga caagccttta cagatatagc cttcagcggc 2043121 agaaaaactg atcattcgct tgagcacatc agcatgcact ttaggatctc taacaatccc 2043181 ttttttgccg acggattccc gtcccgcttc aaactgaggc ttaactaaag ccatgcagtc 2043241 gctgcccggt acgagcaaag tccttaggac aggcaggatg agccgcagtg aaataaagga 2043301 cacatcaatt gtggcaaact ccggcatgcc ctttgtaaag tctgccggtg ttgcataacg 2043361 aaagttcgtc cgttccatca cgacgacccg ttcatcctgt ctaagcttcc atgcaagctg 2043421 attatagcct acatccacag cgtatgactg tttagctcca ttttgcaaag cgcagtccgt 2043481 aaaaccgccg gtggaggagc caatatcaat cataatttta tctttgacag agacgggaaa 2043541 ttccttcaac gctttttcga gctttaagcc gcccctgctc acatacctca gcgggtttcc 2043601 tttgacagtt aacggaaggt cgcggtcaat tttttctcca ggcttgtcca agcggttttc 2043661 gtttgaatag acgatccccg ccataatggc tcttttggct ttttcacgcg tttccgccag 2043721 ccctctttcc actaataata catctaatcg ttctttcttt gacgtcatga tccaattcct 2043781 ttgtgtgtct ttggtggcat cagtaatcta atacgatttg ccacctgctg ttttgtcagt 2043841 ccaatttcct caagaagcgc tgttacactt ccgtgttcaa taaaccgatc aggtataccc 2043901 attctgtcaa tcggagtatg atattcacct tgatcatgag cgaattctaa aatcgagctt 2043961 ccgaaaccgc cttctaagac cgcttcttca attgttaaaa ttggcaagcc ttcttttagg 2044021 atactcttca tcatcttttc atcaatcggc ttaataaaac gcgcattcac aacgcgcacg 2044081 gaaaggcctt ctttctgcag ctcttcggct gcttcaatcg ccatttcgat tgttgtgccg 2044141 aatgttaaga tgacagcatc gttccctgga cgcagcacct cccacgtacc gatcggaatc 2044201 gttttcaact gttcatccat ttttacgccg agtccgtttc cgcgcggaaa acgcattgct 2044261 atcgggcctt cgtcatagct aagtgctgta tgaaccatgt gctggccttc attttcgtct 2044321 ttcggcatca ttaagaccat gtttggaatg tggcgcataa acgcaatatc aaacacgcct 2044381 tgatgtgtct ctccatcagc gccaacgagt ccagcacggt caattccaat aaacacatta 2044441 gcgttttggc ggcagatgtc atgaacaact tggtcatatg ccctttgcag gaaggttgag 2044501 taaatcgcca aaaacggctt cataccctgc attgccatag ctgcagccat tgttgcggca 2044561 tgctgttctg cgattcctac gtcgaacatc cggtcaggga attcctttgc gaagccttca 2044621 agctttgaac cgacaggcat agccggcgta atggctacaa tgcgtccgtc ctcgcgcgcc 2044681 attcgctgca cagttccgct gacaagaccg ctccacgaag gagctgcggc tttcggcttt 2044741 acaaagtcac cggtattaat tttatatggt ccggtaccat gccatgtccc aatcgtatcg 2044801 gtctcagccg gtttgtaccc cttccctttt ttcgtaatga cgtgcagaag aacagggcct 2044861 ttcgtttttt tggcgtattg aagattctca atcagctcat gataagaatg tccgtccact 2044921 gggcccaaat acgtaaaacc gagctcctcg aaaaacattc cggagacgag catgtatttc 2044981 aggctgtctt tgacccgttc cgccgtggcg gcaagcttgc ccccaactgc cggaatcttt 2045041 ttaaataagt attcaagctc atctttgacc cactggtatt tccccgcagt gcggagccgt 2045101 ccgagcatag agtgaatggc accgacgttt ggcgcaatac tcatttcatt atcattaagg 2045161 atgacaatca tgtctttttt ctcgtcgccg atgtggttaa gggcttcgag cgccataccg 2045221 ccggtcagcg cgccgtcacc aatgatcgga ataatatatt catccgttcc tttaatatca 2045281 cgggcagctg ccattcccat cgcgcctgac agagaagtcg agctgtgccc ggtttcccaa 2045341 acatcgtgct cgctttcact ccgctttgga aatccgcaaa gccctttgta ctggcgaagc 2045401 gtcgcaaatt cttttccgcg tcctgtcagc agcttatgga catacgactg atggcctaca 2045461 tcccataaaa atttgtcttt cgggctgtta aattccttat gcagggcaac agtaagctct 2045521 acgacaccta agtttgggcc gatgtggccg ccggaagcgg ataaacttgt aattaaaaac 2045581 tgacggattt catcacttaa tttctctaat tcatcaatgg acatgttttt taaaaacgac 2045641 gggtcctgta ttgataaaag atccaaagcg gatcaactca ctttcagcat gaatttctgc 2045701 aatgatacat gtcttttgca tgccgagctg acaataatct cagacataaa aaaagacaaa 2045761 cgcgcttttc cttttcattt ttcatataaa ctgcttacat tttaccatac ctcgtgcagc 2045821 cgcttcaaat taggatcgtt ttagtgatct cttgccgcaa ttaaatcaca aagctcatat 2045881 aaaaggtctt tttgaagaga gagtccgccg atcaatcgct tcgcctcttt tatatgaaca 2045941 tccaatttat gtttggcccc ttccaatgaa agaagcgacg ggtatgtcga tttgtcattt 2046001 gtggtatccg agccgacacg tttgccgatt ttctcttcac tgccttctaa atctaaaata 2046061 tcgtctctga tttgaaatcc gattccaatg tggctgctga aggtacgcag tgtttcaatg 2046121 tcttcctcag gcgcatcagc caaaatagca ccggcgatta cacaaaagcc aaggagcttg 2046181 gcagttttcc gttcatgaat ggattcgagc tcttcaagcg tgacttgtcg gttttccgct 2046241 tccatatcag ctacttgccc accgaccatg ccttcggtgc ctgccgctga aatcagttca 2046301 ttcacaagcc gcaggcgctt ttctgctgac acctcgtctg acacgtggga ggtaatcagc 2046361 ttaaagcttt ctgtgagcag cccgtcaccc gctaatactg ccgtcgcttc accaaacact 2046421 ttatggtttg tcggcttccc gcggcgcaaa tcgtcatcat ccatgcatgg aagatcatca 2046481 tgaattaacg aatacgtgtg aatcatttcg acagcacagc ccaccggaat gccgtctttt 2046541 tcgctttttc catatgcatt taaaacagcc agtacaatca gaggccgcaa ccgctttccg 2046601 ccggcctgta gagaatatag catagatttc tttaatgagt ccggcatatc aagcttttct 2046661 gtatagacag aaagctgatt ttcaattgtt tttttccggt ccgccagaaa gctcgttaat 2046721 ttatttgtca ccttcgtctt cctcctgaac actgaaaggt gccagttcgc cgtcttcttt 2046781 taaaatgaag tccatttgct tttcgacttt ttgcagcttt tcatggcaca tttttgacag 2046841 agccatgcct tcttggaaat agttaatggc ttgctctaga ggcacatctc cctcttcaag 2046901 ctttgataca atgctctcaa gccctttcat cgcttcttca aatgtcatgt tttcattttt 2046961 tttcacgtct gtcatttttc ttcccctctc ttttctaata cttcacaggt cagcacgcca 2047021 tccttcagct tgatttcaag ccggtcctgc tcttctattt gactgacact tttaatgagt 2047081 ttatcttctt tataagccaa gctgtatcct ctttccatca cttgaagagg acttagtgca 2047141 ttcagcttgc caagaacggt ttgaaattgg gaatgcagct gcttcatttg gatattcata 2047201 ttttttctca gctgatttgt ttgttcctgg tatcgtgttc tcgcttgttt cagctgttca 2047261 tgaggatgca atgcctctaa tctgtacgtt tcacgctcca gctgtctgct tttccgatct 2047321 aaaagagcgg tcagctgtgc ttgaaactgc tggtacgcga ggtcaaactg ctgctctttt 2047381 tgcgcataca aacgctttgg aaaacgaaag gcataggacg attgcagcgt ttgtatccgt 2047441 tcttttttct ggccgagatg ctgctgcatt gctcttgtca ttctgacttc cgctgttttt 2047501 gtccgttcga ttaaatcagt ggtatgaggc acagcaatct cagctgctcc tgtcggcgtc 2047561 gcagctctga tatcggcgac aaaatcacta atcgtaaaat ccgtctcatg tccgactgcc 2047621 gatataatcg gaatattgga agcaaagatg gcgcgtgcta caatttcttc attgaatgcc 2047681 cacagttctt ctatcgaacc gccgcctctc ccgacaatta atacgtcgca aatctctttt 2047741 tcatttgcct cttcaatgcg cgtaacgatg gatctgctcg cattttcacc ttgtacgagc 2047801 gctggaagaa caatgacttt tacaagggga tatcttcttt ttagagttgt aataacgtct 2047861 ctgacagcgg cacccgttgg agatgtcaca accccgattg tggctggaaa tgcggggatt 2047921 tgttttttgt agcggtcgtc aaataaacct tctccggcaa gcttcttttt taattcttcg 2047981 tacgctaaat aaagcgctcc aaccccgtca ggctgcattt ctttggcata taattgatag 2048041 tttccgctcg gttcatatac ggaaattccg cctctgacca gcactttcat tccgttttca 2048101 ggtttaaaag gcagacgctc gctttgtctc gcgaacatca ccgactgcat tcttgcgttt 2048161 tcgtctttta aagtgaaata aatatgccct cgtgtgtgta tctttacatt cgacaattcg 2048221 cctttaatcc aaatattttc aaggtgagga tctacatcga attttcgttt tatatacttt 2048281 gtcagcgctg agacggtcac atacgctgct tcacccatgt ctaaaaactc ctctcctaag 2048341 cattcctgca ccataactaa agaaaacccg ccctggcttt aggagcctga agaagcgggt 2048401 atcgtgctca tattcaaggc gggtaaacat ttcgcctgtg aatatctcca attatctatg 2048461 ataacgtacg tttcgcagat ttaacagtat tatgcgcaag catcgtgatg gtcatcggac 2048521 ctactccgcc cggaaccggc gttatgaagg acgctttttc ctttgcccct tcaaattcaa 2048581 cgtctccgca aagctttccg ttttccagac ggttaacgcc gacgtcaatg acaacagcgc 2048641 cctctttgat ctggtctgca ctgatgaagt tggctctgcc gactgccacc accaggatgt 2048701 ccgctttttt cgtatgttca gtaatatttt ctgttcttga atgacagtaa gtaaccgtcg 2048761 cgttttcatt taataaaagc tggccgacag gtttgccgac aatgttgctt cggccgacta 2048821 caacaacctc tttaccggaa aggtcaatat tggttttctt caaaagctca acaattccat 2048881 gaggcgtgca aggaagaaac gtatcttcgc caagcagcat tttccctacg tttaacggat 2048941 gaaaaccgtc tacatcttta tcaggggaga tacgttcgat caccgctttt tcagaaatat 2049001 ggtctgggag cggaagctga acgagaatgc catgaaactc agggtcttgg ttatattgat 2049061 caataatgga aagcagttca gcttctgtga ggctgctgtc aaattgatcg agcttgaaat 2049121 tcattcccat tgtttctgcc gcttttttct ttcctcgcac gtaagagtga gaagcaggat 2049181 catctccaat caaaataacc gccagtccgg gagtgacgcc ttgcttttta agctcttcta 2049241 cctcttttgc caattgttcg cgtttttctc tagccgtttc ttttccgtcg atgattgttg 2049301 cagtcatttt ctttcctcct atgattgttc aatatcagat ttaatgttag aaagaacccc 2049361 gtttacaaac tttgtcgctt tgtcatcacc aaaccgtttt gccagctcaa tcgcttcgtt 2049421 catggagaca ttcaccggaa tgtcttcggc atatgccatt tcatatgctg ccaggcgcaa 2049481 aatcgcacgg tcaacattgg caatccgatc gagcttccaa ttcaccagat gcttggagat 2049541 catttcatcc agctggtctt ggtgttccaa taccccgtgt acaagctgtt caaagaaagg 2049601 atctgttttt tcttcatcca gtgcgtgttc tatggcttca ttcactgcaa tatcgctgac 2049661 atcaatttga aatagtgcct gcaaagcttt ttctcttgct gttcttcttt tcattttctt 2049721 tctcctttga tcctctttat ccgcttgtcg ttaagccaca aagagatcat aacatatttt 2049781 tttcgtatcc gcatattgaa atcaaggttt ttttacccta ttaccgaata ttttcacaca 2049841 ccttaatatg attattcgga tttcacgttc atgaagaaac tcggctatgt aagccggctt 2049901 tcttcatgct ttgaaataaa gggtaacgtg taaaaaaacc aaagggccgc cctccccttg 2049961 gtttcgtgtt aagccattta catttcttcg tcgatttgga cttcttgggc ttttgtgtca 2050021 aattgaatgc cgacgatgtg aatattgatc tcgttaatcg aaagagacgt catatttaat 2050081 aaggtttgac gaatgttttc ctgaacggat gctgcaactt tcggaatcga aacgccaaat 2050141 gtaacgacac agtatacatc gatcgtaatt ccgtcatccg ccaggtcgac tttgacacct 2050201 ttgccatgat tcactttgcc aaagcgctca acgacgcctg tcgcaaagtt tccgcgcatt 2050261 tcggcaactc catcaacttc tgatgctgca atgccggcaa tgacctcaat gacctccggt 2050321 gcaatctcaa ccttacccaa atgcgtatct tcgtgatcca ttttaagcaa gctgttgtct 2050381 ttcattcaat tcacctccgt aaaaattatg agcccattac atcatatgtt tctaaaaatt 2050441 tcgtattaaa ctctccgctc acaaatgttt cgtgttcaag cagttttaaa tggaaaggga 2050501 ttgttgtctc aatgccttcg atgacgaatt cgctcaatgc gcgcttcatg cgggcaatcg 2050561 cttcatctct cgtttttccg tatgtgatta cctttgcaat catgctgtca tagtacggtg 2050621 ggatggaata gccagggtac gcagctgaat cgacacggac accaagaccg ccaggaggca 2050681 ggtacatttt aatttcacca ggtgacggca tgaaattttt gcttgggttt tctgcgttga 2050741 ttcggcattc gatggcccag ccttcaaatt caacatcttc ttgcttgagg ctcagttcca 2050801 ttcctgaagc cactttgatt tgttccttga tcaggtcagt tcccgtcacc atttctgtga 2050861 ctgggtgctc cacctggatt ctcgtgttca tttccatgaa gtaatagcgc tgttcattgt 2050921 agtcatagat aaattcaact gttccagcac ctgtatagcc aaccgctttg gcagccttta 2050981 ccgctgcatc tcccatttgc tccctgattt ctgaatcaag ggcaggagat ggtgattctt 2051041 ccaaaagctt ttgcaggcgt ctttggatcg agcagtcgcg ttcgcccaaa tggatcgtat 2051101 ttccgtagtt atcagcaagc acttggatct caacgtggcg aaaatcttct atgtattttt 2051161 cgatgtatac acctggattc ccaaatgcag ttgccgcttc ctgctgtgta atcttaatgc 2051221 cattaatcag ttcctcttca gtgcgggcaa ccctaattcc ttttccgcct ccgcctgcgg 2051281 tggcttttat aattacagga tacccaattt cattagcaag cgaaaccgct tcttccacat 2051341 tttctataat tccctgtgaa cccggtacga ttggcacgcc ggcctgtttc atcgtttccc 2051401 gcgcaacgtc ttttgttccc atttttgaaa tggcgtcagc gctcgggccg acaaacgtga 2051461 cattcacttc ttcacataat tcagcgaaat cagcattttc agctaaaaat ccgtatcccg 2051521 gatgaatggc gtccgtgcca gtcagctttg caacactcac aatatttgta acgtttaaat 2051581 agctgtcttt tgatgctttc ggtccgatac aaaaagcttc atcggccatt tgaacatgaa 2051641 gggcatcttt atcagcttct gaataaacag cgacagtctc aattccgagc tctctgcagg 2051701 ctctgatgat tctgacagca atttctcctc tgttggcgat caatagcttt ttaatcatgt 2051761 tcagtctcct tactccgctt ttacaagaaa tagaggttgt ccgtattcga ccagctggcc 2051821 gttttctact aatacttcaa cgatttcgcc tttcacttct gcttcgattt cgttgaaaag 2051881 cttcatcgct tctacaatgc agacaactgt gttttcattt acttttgaac cggctgttac 2051941 atacgggcca gcttccggtg atgaagaagc ataaaatgtt cctaccattg gtgaagtgat 2052001 tttatgcaga ttctcatctt gctttggtgc ttcttgggca ggtgccgctg cttgctgcgc 2052061 ttgcggctga actgcctgcg gagcctgtgc ttgtacaggt gctgccggtg cctgctgcat 2052121 gacttgaacc gtgcctgctt cgtgtttttt cagttttaag gatacacctt cattttcata 2052181 tacgaattcg tcaattgtag actcgtcaat tgctttaatc agctcgtgga tttctttgat 2052241 atttaacatt caatcgcact cctatgtatg aaatttcttt ttttataggt tactactaaa 2052301 agtacatact atgttcatct tacaggagcg gacttttgaa ttcaactcta atatgacagc 2052361 aacgcaaaaa gcccgcttgt ttagcgggct tttttccctc attcttattt agagggttca 2052421 aatgtgacag cgacatcttt cattgttttg atttcttttg ccacaaggtc tataatggct 2052481 gtcgccttcg atttagagtg tttgtctgat ttgactgtaa tattgatttt atctccttca 2052541 gcattaacaa gcgcatcctc gtaaccttgt gttttaatca gcgtttccag ctgtttttct 2052601 gttccttcca cttcactgag agccgtcatt ttatcgtatg cttcgctttt ctccttggct 2052661 gttgcatcat cgcttgacac aatggcattc agctcttctc tttctttgct tctggcatct 2052721 tctaaatcaa gacggtacgt tgtaaacaaa tcatcatcgg ctgtttccgt aacaacagtt 2052781 cctttttcac tggcttcagc ggatgtttcc ttgtctgctg atgaatcttt cgttcccttt 2052841 gttccatctt cttttccttt ttcagtttct gtaccgcttt tttccttcgt gtcttgcttg 2052901 gcaggcgctt tttcagttgc gacctctccg ctgtcagacg cgcttttttc actttgcatc 2052961 tgcacggcgt ttttgctttc cggcgacatg atatagtaga cgcttaacac cacgacaaga 2053021 ctgagcattg ttaatagcca aacggtttgt tttttaagca tttatgaatc ctcctttatt 2053081 tttttagggg caaccgcaac ccggtggctt ggaacatcca ggacccgtgt caccgcttcg 2053141 ataatggttt gttttatttg aacgttgtcc actccttgag caacaacgag tacaccgcgt 2053201 atatcaggtt ttttcgtttg gacgacgaca ggtgtttctt tatcgccgtt tttgatcatg 2053261 acgatttctt cctccgatga ttggtctgta acgcttcttt ttccgccttc tttgtcagtt 2053321 tcttcagtgg ttgtattttt gtttgatttg tttttttcgt atactttcag cgacgttgca 2053381 tctacattca cgacaaccga gacatcgtcc acaccaatga ttgtttcaag aatttctttc 2053441 agttgatttt cgtattcttt ttcatagtca tcgatcgagt ctttaggttt atcagatttt 2053501 gaggctttaa acacttcggc tgttttctct ttgctgtctg cggaatgttg tgatgatacg 2053561 gccgttatcg ttttggcgtt ttcagttttc tcaggtgaag aaaacagctg gctgacaagc 2053621 ataaaggaaa ctccgagaac aaaaacgaat agaaagtaat gatatttggt cagcttcggc 2053681 ttttcgccgt ccttcgtttg tcccggaaga aactgctttt tcaatacatt ccataatccg 2053741 tttttattca ttgccgacac tctccccgcc ttccatatga accgtaattt tctcacttcc 2053801 gatttcccaa atgtccgcga gctgcgtttg tatctgtttg gcttcttttt gttcggctgc 2053861 ttcttttgtt acgtatgcat gatctgtatc aatgtggacc ggcgcgaccg tttggaccgt 2053921 tttttcagaa gacggggcca tatacacgct gattgtttta atatcctctt ctgaatctac 2053981 cttttctcct gccgtgagtt tgatgcggcc tactttatat tcatcatgac tgaatctctc 2054041 ctccgctttc ttttttagtt ggacagccat ttcttctaga atatatgcgc gctgggaagc 2054101 ttgtatttct attttttttg aattgatttg attttttatg tcggcagact ctgactgccc 2054161 gttttttgtg aggtattcaa agatgacttc ggggtctgtc ttgaaaagtt taaaaatcgg 2054221 cgtaagcatg acgacaatca agagcaggct gactaccatt tttgcgtact tttgcatgct 2054281 ggagctcggc agcagcatat caatcacaat tgcaaatagg ataaacaaca cgatggtggt 2054341 aagccattcc gttaaaaaac tcatttgcct gcctccttca tttcatcatc atcgtgaggt 2054401 ttccggctgt gattatgaca gtaaggctta aaaaaaacat gagagacaca atggcgagag 2054461 ctgcaaaaat ataaatgacg cttttgctga tgacgtcgag gcaggtgatg acgggcccgc 2054521 ctcctagcgg ctgaagaatc gcggctgcca gcttataaat aaaagcgagg gaaagcactt 2054581 tgattgccgg aaatgccgca atacagatca aaatagcgac accgagaatc cctaccgtat 2054641 ttttcagcag taaagaggcg ctgattactg tatctgttgc gtctgtaaac attcggccaa 2054701 gcacaggaat aaaatttccg gttataaatt tagccgtcct gagcgtaatg ccgtctgtca 2054761 ctgcagctga cgctccctga acagagatga cgccgagaaa gatggtaaga aaaacagcca 2054821 gtgctccgat ggcgatattt ctgagcaggt tagccagctg cgttactttg tattgttcag 2054881 tcatcgtgct gacaatgctc agaatcgctg ataaaaaaat cagcggcatg acgatattct 2054941 gaatcaagag accgctcgtg ttcatcagga agaggataac aggatgaaag aaggcagcag 2055001 atacagctcc gcctgaggaa gccaaaagcg ccaagaggag cggaatgagc gccaggataa 2055061 agctggtcat cgtctgaatc gcctcagttg catagttaat tgccacatga aagctattaa 2055121 gcgcaaggat aatcagcacc atgtacacaa ttgagtaagc gaccttactg acggtgcttt 2055181 gctgaaaagc attttgcaaa agctgcagaa tgacgcaaaa aatcgtgagc aaaatcaatg 2055241 tgcccagcag ctttccgttg gcaagcactt catgaaacaa ataagaaaag agagctttca 2055301 gccattcttg cggtgagaat gatttatcgc cattgataaa ctccattaag ctgccttttt 2055361 ggctttccgg cagcagtccg ccgtattctg tcataatgtc attccaaaat tccccgatct 2055421 tatctgtttc aagcgaggct gctgtccttt ccgctaattg ctcggctgtt tcagcatggt 2055481 cttccgtttg ttctgcatta ccagctgctt gtacaatttc tgcacggcct gctatgatca 2055541 gcacggccaa aagcaaaacc cattgaaagc gcttcaatct accgcctcct ttcggttatg 2055601 acatagaagg tataagtccg agaatcgttt cgataatgac ggttaaaata ggcacagcca 2055661 ttacgagtat taaaattttc cccgccaatt ctattttcga ggcgatggct ccttgaccgg 2055721 catcttttgt gagctgtgcc ccgaattcag caatataggc gattccgata atctttaaaa 2055781 tggtttcaac atagaccatg ttgacatttg cattaatcgc aattttttct atcattcgaa 2055841 taatgtcgta gatttggtct accaaataaa gaaaaatggc acatccggca aaaacgacga 2055901 ttaaaaacgc aaaagtcggc ttttgttctt ttacaattaa agaaaggaag gtggcgatca 2055961 gccctaaacc tacaatttga acaatgtcaa tctgcaagcc cccctatcct tggaataaaa 2056021 acacagcttt tatcttttta aataggtcat ctacaatcgt ggcgaccata aataaaatat 2056081 agataaaacc taacagcgtc acccactgag catattcttt cttgcccatc tgatccaata 2056141 tcgtgtgtaa aaaagcgacc acgattccca ctccggcgat ttgaaatatg acattcacgt 2056201 ctactcccat tttatttttg ctcccctcac gtttacatca atagaagaat gagtaacaag 2056261 cccgctaaaa agcccaaact ttttatcatc ttttcgtttt tcgcttgcgc ctgctcagca 2056321 tccgcttctg aggcttccaa atgtgtcagc gccagcttga tgtgcttttg ctgagagatt 2056381 cgatcatgaa tcccaagcgt ctcgccaaac tgcttcagca cttcgtattc gctttttttc 2056441 aaagacaggg tgtcccatac cttctttaag ctttgctccc acgccgtttt cgcggaatca 2056501 cttcccttgt ccagctgatc actgaatgcg gaaaaaagag ttgaaacagg ctgtgcgagc 2056561 tgtttggcaa tctgctgtga agcagtatga agcggtgtat ggccgtacat gatttcagcc 2056621 tcgagggatt gaagcgccgc acgcagctgg cggatttgcc gcggccgttc tgtataaatc 2056681 ttcgccatct caaaacctgt ccatgttgtc gctaccacaa tgaatacagc gcccagcagc 2056741 ttcagcatgt tttcacgccc gtcgtcctag acagcacatt tccgtctttg tcataaattt 2056801 ggctcactgt gcccggccct tttgctcttg ataattccaa atagcggtca aaggctcttt 2056861 cttcccacaa acgcttcaat gaaggccgct tcatcaggtc ggatatactc cagccatgcg 2056921 ccgatacgat tactgaaaca ccggcatgca gcgcctccag aagtgcatct gtatcttcca 2056981 tacgcccgat ttcatcgaca atcatcacct cagggctcat ggatcgaatc atcatcatca 2057041 gcccttcagc ttttggacag gcgtctaaca cgtcaattct ctgaccaaat tgatgctgcg 2057101 gaataccgcg aagacatccg gcaatctctg accgttcatc gacgatccct gtctttacgg 2057161 gcagcatgtt ttttttgccg gtgcttgaga gcctcgcaag gtcccggaga agtgttgttt 2057221 tgccggtttg gggcggtccg ataatcagcg tattcagcca gctgttttga tataagtatg 2057281 gaagcagcgg ctccgcaatc cccagctttt gccgggcaat tcgtatatta aaagatgcga 2057341 tgtcacggag gcctttcaca cctccgtttt ccgtaatgac tctgcccgcc agtccgactc 2057401 tgtggccgcc tctgatcgtg acataccctt tcttcagctc ttcttcaagt gtatacatac 2057461 tatagttgct gagccggctc aggatcagat gggcatcctc ggccgtgccc gcataggaca 2057521 aataaacagg ttgtcctctt cgaatcaatt caacagggcg gttgatccga attctgactt 2057581 cttcgatttc cagccattgt tgttccggta tttcagaaag ggcgtttttc atggattcag 2057641 ggagaacctc agcgatttca ttcaacagag cctcctcctt tctaccgatt ggcttcttta 2057701 aaatgtatga tgtgaggcag actttatgac aagcctctct ttatttatga acacccgcca 2057761 aaatcaagac aacacccgta aaaatcagaa tcagctttgc atacgaaagc tgcccggcaa 2057821 tttggtagat tccgacagtc attgtaatga taaaaatcaa cggaccgaca atagcgagaa 2057881 tgctgttaac cacaaccgcc ttccggacat cgttggtcac aagcatgaca attgctgccg 2057941 tcagctcaat catagaggat aaaactcgta atcccgccat tgttaaaaca gtagaattga 2058001 tatttccaag taaaaatttc atagcactct cccaacctcc cattttttta tatgatatgc 2058061 tctagcttgc tgaagtagtc ttgtcatttt cgtataaaag aaagattctg tttttgggca 2058121 caaaaaaagc ctgctcccat ttgggaacag acttcttttt ttctttctat gctcttgaaa 2058181 cgtaagaacc gtctgatgta ttgacaacaa gtgtgtcgcc ttcattcaca aagaacggca 2058241 cgtttacaac aagcccggtt tcagttttcg caggttttgt accgcctgac gctgtatcac 2058301 ctttaatacc aggttcagtt tcaacaactt tcagctcaac tgtgtttgga agttcgatac 2058361 caagtgtttc atcctggtac atcatgatat gcacagacat gttttctagc aggtatttta 2058421 attcttcttc gatttgagtt gcgctcagtt caagctgctc ataagaagaa gtatccataa 2058481 atacgtgctg atctccgttt gcatatagat attgcattgt tttggtttcg atttgcgctt 2058541 tcgctacttt ttcaccagcg cggaatgttt tttcctgaat cgcgccagtg cgaaggttgc 2058601 ggagtttaga gcggacaaat gccgcacctt ttccaggttt tacgtgctgg aagtcaacga 2058661 cgcgccaaat gccgccatct acttcaattg ttaatcctgt acggaaatcg ttaactgaaa 2058721 tcatgtttaa tgtcctccta tattccaatc acaaaataat aagttctttt ggggaatggg 2058781 tgattgtccg gttgccgttt tctgtaatca cgatgtcatc ttcaatgcgg acaccgcctg 2058841 tttctggtat gtaaatgccc ggctccactg tgaccaccat acccggttca aggatagctg 2058901 aagatctgac ggataatccc ggcgattcat gaacttccat gccgagcccg tgcccggttg 2058961 aatggccgaa atagtcaccg tagccttttg cagcaatatg atcccttgtg agggcgtcag 2059021 cctcttttcc tgtcattccc ggcttaatat gtgcgacgcc aagcgcctga gcatcaaata 2059081 caacctgata gatctccttc aattgatcac tgggctgacc tacagcgacc gtccgggtaa 2059141 tatcagaaca atatccttta taataagcgc caaaatcaag cgtaacaagg tctccgcttt 2059201 caatcagttt gtcactggcc acaccgtgcg gaaggcttga acgaaggcct gaggcgacaa 2059261 tcatatcaaa agaagagctg tctgctccct ggcttctcat ataaaactcc agctcattgg 2059321 caacagcgat ttcagaaatg ccgggtttca taaacgtcaa gatatgtctg aaggcatcat 2059381 ctgcaatctt cgcagcttcc tctaatatct taatctcttc actagactta atcaagcgca 2059441 acttttccac ggattcagcc acaggcacta attcggcatc actgataacg gcgctgtatg 2059501 aagcgtaagt gccatatgtc atgctgttct gttcaaagcc gagacgcttg atgccaaacg 2059561 attcaacagt gtcggcagtg gtctgaatca agctgccgcc atgttcaatg atctcaaaac 2059621 cctttacctg aaccttcgcc tgctcagtat aacgaaaatc cgtaataaac gctgctttgt 2059681 cacccgatat aacagccaaa cccgccgaac ctgtaaaccc tgtcatatag cgtacattag 2059741 tgttgcttgt aatcagcatg ccgtcaattc ccagctgtcc aaacaggttt cttaatttct 2059801 ctagcttcat cttgattctc ccccttgctg gcttaataag tagcgaacag caagcttgta 2059861 gccttcagct ccaagaccga caatctgccc tttcgcaaca ggagcgataa ccgactgatg 2059921 cctgaattct tccctggcgt ataagtttga taaatgcacc tctaccacag gaagactgat 2059981 gcttgaaaca gcatccctga tcgcatagct gtaatgactc agggcgccgg ggttcagaac 2060041 aatcccgctg tattgctcct cagcctcatg tatcgcatct atcaaatcac cttcgtgatt 2060101 agactggaag aaagtgagct ggatatgtaa ggcttcagca aactgaaaaa gatctgtttc 2060161 aatatcggtc agtgtctggc ggccgaatac ttcaggctca cgactcccaa gccggttaac 2060221 attcggtccg ttcaaaatca aaaaatgagg cacacaatct ctccttttcg cgagggtttc 2060281 tcatgtaaaa aatgttcact tctcgtgaac attttatcat actggaaaag gattatacac 2060341 tattctctat gcattcccag cgcacgtgca agcttttccg aattcagctc attgtattca 2060401 aatgaaatag aatacccgac aaacagcccg taaagcaaat aaatgcaaat ggtcgtaata 2060461 attgtatctg atgtcagttc ggtcaccgtg cgcacatctg gaaaaatcgg attaaaaaca 2060521 aaaaacacga gcagccaaag caccaagccg tataaaatac ccggccacat tgtttttaaa 2060581 cgtttcaata gaagaaaata aagaaatgct gcgccaattg aaattactcc aatcaaaatg 2060641 atgctgatta ccgttcccag cccatgtttt ttccactctc cgagtacaaa cggctgcaat 2060701 atcatattcg ggctgatttc ggaaaaatga aacaaatatg cgatataagc aacgaaactc 2060761 caaagtacgc ctccgcaaaa acctgttgcc gccaccctgc cggccattga aacaggcggc 2060821 ttttgcttct cattcaattc ttcattttgt tctgtatctt tttcgcttgt catcatggca 2060881 cctccagtta aagtgtgccc aaaaaatgaa atgtcaataa aaaagctcac actttttggc 2060941 agctgcgagt aaaatttgaa aataacgggt ataatgcatg tagaaaaagc aaggctatgg 2061001 caattttttc agcctgtcaa tctagaggtt tagcgctgtt tcctgtacaa tagagtgaaa 2061061 ggaaatggtt agcaatccta aagaaatagg caggttgata atatgtcaaa acataaagtt 2061121 ccgcccgctt acggcgggca ggctgttgtg gaaggcgtta tgtttggcgg aaagcatcat 2061181 tacgttacag ccatcagaag aacggatgga agcattgact tttttaagct tccacgcaaa 2061241 cacaacccga aactgaacat cgtgaaaaag ataccgtttt tacgggggat cgcggccatt 2061301 atcgaagcga gtgcaaacgg cacaaagcat ttgaattttt caagcgaacg ttacgggctc 2061361 gatccatctg aagacgagac acttgagcag gaagaaaaaa aatcctctgg gctgtctatg 2061421 tatctcagcc tcgcagttat aggcgtccta tcatttttgt tcagtaaatt cgtatttaca 2061481 ttggttccag ttttcttagc ggaactgaca aggccgattt tttccttgaa cacagcgcaa 2061541 atcgcgattg aaagcctgtt taagttgatt ttgctgctcg gttacatcta ttttttgtcc 2061601 atgacaccgc ttattaaaag agtgtttcaa tatcatggag ccgaacataa agtcataaac 2061661 tgttatgaac agaatttgcc aattactgtg gagaatgtcc aaaaccaatc tcggcttcat 2061721 taccgctgcg gatcaagctt tattttattt acgattattg tcggcatgtt tgtttattta 2061781 ctcgttccga cagatccgct ttggctgcgt gttatagatc gtgtcgcact gataccggtc 2061841 gtgcttggta tatcctttga agttctgcag ctgacaaaca aagtgcgtga cattcccggt 2061901 ctgaaattac ttgggtaccc gggactttgg cttcagctgt taaccacaaa ggaacctaag 2061961 gatgaacagg ttgaagttgc catcgaaagc tttaacgaac ttctcagact cgaagcattg 2062021 tctgagcaaa atcagaagcc ttctcacaac gtcatctaaa atccgttgcc ctgctattac 2062081 tttcggaggt ggacagttat gaatcatcgt gtacaaccta ttattgctgt attaattgcg 2062141 ctgggagcgt tcggtttcct ctatgtgctg gtaaccaatc ccggagaaat ggcaaaaatg 2062201 gcggtaaccg tcatcgtggc aggtatcatt atttatttta ttgtgaaata tgtaatgaat 2062261 cgaaatgcgg gcagcgaagg agcagccttc aaaaaagcgg cgaaacaatc acggcgccgg 2062321 atgaaagaac aaaaagcaaa acaccgcgcc ggacataagg gacgtgtcag ccacctgcga 2062381 agcgttccga gcgccagcaa gcctaagccg atgattctca agaaaaaaag ccagactcag 2062441 ctgactgtta tagaagggaa aaaaaataaa aagaaaaaca gagcgctttt ttaataggtc 2062501 cactgcttta aaaacagctc tgtccgtctt ttacctagct caatcagggc tagttttttt 2062561 tgttgtgtta aatgaaaatc agtggccatt acgtcatcaa cagggagaaa aatgatattt 2062621 tgttcatagc gtgacgcaat gtgccttgcg tcatgagcat ccttcatcgt ttcaaacagg 2062681 gcgccgaaca gttcaaaagc gttgcggata ttttttttcg gacgctctct ttcacgcggc 2062741 gcaagcgtga caccgatcac agggcgcttt ctttcctttg aaaacagcca gattggaaaa 2062801 ttgcttaaca cgcctccgtc gacaaccgtg gcggtgcctg tgtccgtttt taattttatc 2062861 ggttcaaaga aatacggaat gctgcagctc attctgaccg ctctggcaac cgggaacata 2062921 tctggattta acccgtaacg ggccaaatcg tccggcaaaa caatcatggt gccgtttgtc 2062981 agatcagaag caataaggcg cagagaccct ttctgcaaat cgccgaaaac ccttatgcct 2063041 ttcgctctta acagatcagc aatccatttt tctatcgtat cgcctttgta taagccaaga 2063101 cgccagtaga tggacaccca ctggagcatc tttaagggga gaaatgagta cctctgatcc 2063161 agcaatttct ctccgtccac ttcttcaatt aaagcgtgga tttccttact ggtgtaacct 2063221 gacgcaatga aagcggcaat aatggcgccg gcgcttgtac ccgcaactct tttaaagcgg 2063281 aagccttttt cctcaagcac ttcataagcg cctgcgagcg caatgccttt tactcctccg 2063341 ccggaaaaca caccgtcaat atacatctca ttccctcccc ctccatccga tcgtttatta 2063401 ccattttaag aaaacacgcg aagaaataga ccaacgaatg acgggtggcg tcagcgtatc 2063461 aaaaaagacg gcctccttcg agaccgcctt tttactgatt atgatgttct gttttctttt 2063521 ggattgattt cagatctttt ttacgggcat catcttcttc aaaatattga acaagatccc 2063581 cgatgcgatc aatactgttc cagcttaaat gatgttcgat tccttcgaca tcgttatata 2063641 ttttctcttc atcaacacca atgattctta aaaactgctc aagcaattca tgtctgtata 2063701 ccagccgttt gcctattttt ttccctttag acgttaacac gagaccgcga tatttttcat 2063761 aaattaaata ttcgtcttta tctagttttt gaaccatttt tgttacagag gagggatgga 2063821 ctgccaatgc ttccgcgata tcggaaactc gtgcatatcc tttttcttca atcagcatat 2063881 aaatctgttc aatataatct tccatacttg gtgttgtcat cgaaaccctc ccaaaaagca 2063941 ccttaacttt ataaaccatt acaagtttac actaatgaac ttgaaaaaac aaggatgctc 2064001 cgcgggtcaa aagccctgtt taccgcttat aattccattc atctgaagcg tactttgttt 2064061 cagccaagtg atgaacaaaa tcaagctctt cctgagaaag ttcatatggc tccaaatgaa 2064121 tgttaagacc tgtttcaaat ccttctttaa aggctttacg agcctcatcc atcgtcaccc 2064181 gcttttcgat gagttcatta atggcaaccg ctttattttt gaaattgcgc tgcatccgct 2064241 ctcttactct ttcacttgga tataagaaca gatcgaacag cttgtcctca tctaaatcaa 2064301 gaagaatgga gccatgctga agaatcacac ctttttgtct cgtttgcgcg cttcccgcca 2064361 ccttgcgccc ctcaaccact agttcatacc acgaaggcgc gtcaaaacaa acagatgacc 2064421 gcggattttt taagctttct ttttcttttt cagttctcgg gatggcaaag taagcgtcca 2064481 gaccgagatt tctaaagcct tgaagtatgc cttctgaaat aacccggtaa gcctcagtaa 2064541 cagtcgccgg catctcgggg tgctcttccg aaacaattac gctgtatgtc agttcctgat 2064601 cgtgcagcac acctctcccg ccggtcgggc gtctgacgaa tccgagatta tatttatgta 2064661 ctgcttcaaa attgatttcc tttttaatat tttgaaaata ccctacagaa agtgtcgccg 2064721 gattccagcc gtaaaaacgg ataaccgggg ggattttctt ttcgctgtgc caatataaaa 2064781 gcgcttcatc aagcgccata ttgaatgcag gacttgcatt gcctgagtct ataaaccgcc 2064841 aagtttcttt ttgcatttta agaccttcct taccgtttta atagaatcag tttatcaaac 2064901 tgtcgggaaa atgaaaaata ttttagttcc attatagatg acaatcacgc tgtgctttac 2064961 tataatagta tttgtcgaaa acggctctat gaccttgttt tatgaagcag ggttttgatt 2065021 ttatatgcta aaggagtaga atcacattgt ctaatatgat cgttttgatt atttttgctg 2065081 catttatcat ctatatgatt gcttcatatg tctatcagca gcgaattatg aaaacactta 2065141 ccgaagaaga attccgcgcg ggttaccgca aagcgcagct tattgatgtt cgtgagccaa 2065201 atgagtttga gggcggacat attttaggcg cccgcaacat cccgctttcc cagctgaaac 2065261 agagaaaaaa tgagatccgt acggacaagc ctgtttacct gtactgccaa aacagtgtcc 2065321 gcagcggacg cgcggcacaa accctgcgca aaaacggctg cactgagatt tacaacctaa 2065381 aaggcggctt taaaaaatgg ggcggaaaga ttaaagcgaa gaaataaagc aaacagctgt 2065441 ctggtagaca gctgttttta tttatctttc ttccgcctcg tatctgagca ctgggtgtct 2065501 cgccgctttt gtttcatcca ttctttttac aatcgttgta tgcggggcct cctgaacaag 2065561 ctccggattc tcctccgctt cttttgcgat ttgaatcata gcatcaataa acgcgtccag 2065621 tgtttccttt gattcggtct ctgtcggctc gatcatgatg cattcttcaa cattaagcgg 2065681 gaaataaatc gtcggcggat gatagccgaa atcaaggagc cgttttgcaa tatcaagcgt 2065741 acgcactccc agctttttct gccgcttccc tgataataca aattcatgct tgcaatggcg 2065801 gtcaaacgga agatcgtaat aaggcgcgag ttttctcatc atataattgg cgtttaacac 2065861 tgcgttctca gtaacagcct ttaatccgtc aggccccatg gagcgaatat acgtatacgc 2065921 tctcacatta atgccaaagt tgccgtaata cggcttcaca cggccgatcg catgagggcg 2065981 gtcataatca aacgtaaagc gcccttcttt tttgactaaa actggctttg gcaaataagg 2066041 aatcagatct tgttttacgc cgacagggcc tgagccgggg cctccgccgc catgagggcc 2066101 tgtgaatgtt ttatgcaggt tgaggtgcac cacgtcaaat cccatatcac caggtctcgc 2066161 cttgcttaaa acggcattta aattagcgcc gtcataatac agtttccccc ccgcttggtg 2066221 tacaatttcc gccatctctg taatctgctc ctcaaacaag ccgagcgtgt tcggattcgt 2066281 cagcataaga gctgcagttt cttcattcac tgctcttttt aaatcctcta aatcaacaag 2066341 ccctttttca ttcgatttca ccgtaacggt ttcaaagcct gctactgttg ctgatgcagg 2066401 attcgtccca tgcgcggaat cagggacaat gaccttcgtc cgcttgaaat ccccgcgagc 2066461 ttcatgatag gcacggatca tcatcagccc cgtccattcg ccgtgcgctc cggcagcagg 2066521 ctgaagcgta acctcatcca ttcccgttat ttcttcaagg tgtttgctta aatcatataa 2066581 aagctctaat gcgccttgca ccgtgtcttc atcctgaaga ggatgaatcg cagcaaaacc 2066641 aggaatacgt gcgatttttt cattgatttt cggattatat ttcatcgtgc aagaaccgag 2066701 aggataaaaa ccggaatcca ccccgtgatt gcgtttggac agcgctgtat aatggcgcat 2066761 gatgtccagc tctgaaacct ccggcagcgc tgcgtcttcg tcacgaatat aggtgtctga 2066821 caagaggtcc cccaattcga tttccggtac atcgagctcc ggcagactat agccgattcg 2066881 gccttctctt gaaagttcaa aaataagtgc ctggtcctga ttactcatgg cgatccccca 2066941 attcctgaat gagtgcgtca atttcttctt ttgttctcag ctctgttaca gcaatcagca 2067001 tatggcagtc cagctctgga tacgtcaacc caagatcata tccgccaatc atgccttttg 2067061 ccagcaaacg cttgttcaca gctctcaccg gctcatccag tttgatgaca aattcattaa 2067121 acatcggccc gtcaaacata acagtaaggc ctgctttttt tgcttcttgc tttgcatagt 2067181 tggcttttaa gagattttgg cgggctatat cttttacgcc gttttttccg agagcagtca 2067241 tggccactga tgctgccagc gcatttaaag cttggttcga gcatatattt gatgttgctt 2067301 tatcccggcg gatatgctgc tccctggctt gcagggtaag cacaaagcct ctttttccgt 2067361 tttcgtcttc cgtttgtccg acgagacggc ccggcacctt tctcattaat tttttagtaa 2067421 cggcaaaaaa gccgcaatgc gggccgccgt atgctgaagg aatgccgaaa ggctgcgcat 2067481 caccgacgac gatatcagac tgaaacttgc ccggcggagt gagaagacct agcgccagcg 2067541 ggttggctga aacaataaac atggatttcc cttgatgagc gataggctca atatccttta 2067601 gcggctcgat cctgccgaaa aaattcgggt actgaacgat cactgcggct gtgttctcgc 2067661 aaacggtttg gcgcaatgca tcaagatccg taacgccatc cgcagcgggt acttcaacaa 2067721 catcaatata ctgacctttt gcgtaagttt tcagcacctc tcgcgattca ggatgcacgg 2067781 tttttgacac aacaattttt ttctttttcg tgtggcctga agcaagcatt gctgcttctg 2067841 ccaaggctgt tccgccgtca tacatcgagg agttggcgat atccatgcct gtcagttcac 2067901 agatcatcgt ttggaattca aaaatagcct ggagctctcc ttgtgaaatc tctggctgat 2067961 aaggcgtata tgcggtataa aactcagagc gcgaaatgac atgatccaca atgacaggct 2068021 gatagtggtc atatacaccc gctcctaaga aagaagcgta ttgtacggta tcacgatttt 2068081 tagaggccag ctttgtcagt tctcttgtta attctgtctc tgatttcgct tttttgattt 2068141 gatgctcttt tttatatttg acgttttccg gtatatcagc aaataaatca tcgatgctgc 2068201 ttacgccgat agtagcaagc atctcctgtt tatccttttc tgttgcgggc aaataacggt 2068261 gcttcatgtg ttgtctcctc tctccaagaa aaaatattag cgtttataaa atggtgtttt 2068321 gacaaccttt gctttcacta attttttgcg tatctctaca tctacaacag tcccgatctc 2068381 actcgtttcc gaatcaatta aggcaaggcc gacgtttttt cctaatgtcg gtgactgcgt 2068441 gccggttgtc acctttccga cagacttgcc attttggaaa acctcatatc cgtgccgcgg 2068501 tatccctttt tcaatcattt cgagaccgac aagtttgcgc ttcgctccgt tttctttttg 2068561 ttcactcaat actgacttac cgaaaaagtc agactccttt ttgtgcttta cagcaaagcc 2068621 tatacctgct tcaatcggtg taatatcccg ggtcagctcc tgaccgtaga gcgggagctt 2068681 cgcttcaaac cggagtgtat cacgtgcacc gagaccgcat ggaatcaatc cgtatgcatc 2068741 ccctgcatcg atgatttttt tccaaatatg catagcatca tcactgcggc agtaaatttc 2068801 atacccgtct tctcccgtat agccagtgcg tgaaataagt gctttgcggc cgctgatatc 2068861 ggcttcatca ataaacgcaa acggctttaa tgcagacaca tccgcatctg tcagattttt 2068921 taagatcgct tctgctttcg gtccctgtac agccaagagc gcgatttgat ctgactgatt 2068981 gtcaatctgc acatcacctg ctgcatgttc tttcatccaa gccaagtctt tatctatatt 2069041 agaagcatta atgacaagca gatagcggtt ctctcctttt tgatagataa gcaaatcatc 2069101 gacggttccg ccatccgggt aacacatcgc tgtatattga gcacggcctg gcgttaacgc 2069161 ggaaacatca tttgtcatca atctttgcaa aaaagacaga ctgtcgttcc ctgacacttc 2069221 gacttctccc atatgagata catcaaacaa accggctgca gttcggacag cctcgtgttc 2069281 tttttttata gaagaaaatt gaacaggaag ctcccagcct ccgaaatcaa tcgtttttcc 2069341 tccatattcc ttatacaggt caaataacgg cgttcttttc agcatctaat tcctcccctt 2069401 tatcaacggc gcagctaaaa aacatacaaa aaaggacaga gaaacacctc atgtaaaatg 2069461 aaggttctct gtcctggcac ctgaaagttt actttgcata cgcaaagacg tcccctttgg 2069521 tggtttgcgc atccgcacaa acactctcca gagttgcgtc gagcaagagt tcttttgcct 2069581 gagagattca ctccgcagtt tgctccttcg gcgcctgtat cccgaggttt tcggtcaggt 2069641 ctctcccctt gctgtcattc gctcatattt tcatgctgtt atggacatac tatagcaata 2069701 tcttacatca aatacatact catatcctac catcatcact atatgctggg caacagcaat 2069761 ttgggcagat ttttcttata ttattcatct taagaatcga agaataagaa aggcggtttc 2069821 aaagcaatga atacagaaat gatctacgat gcaaaatggc ctgaagaatt tgctgaaaga 2069881 ctgaaaaacg atggcccttg ggcaaactgg gaactgtaca agctctctgc agaaatccag 2069941 aaaacattag caattccaga gtttgaaggc ttacgggctc ctttatatct gccttccttt 2070001 acgccgctcc cccaccagct tgaagtggcg caaaaagtgg ttgaaaaaat gaacgggaaa 2070061 gcgattttag cagatgaggt tggtctcgga aaaacggttg aagctggact gattctaaaa 2070121 gaatatatga ttcgcgggtt agcaaaaaaa attttgatcc ttgtgcccgc ttcccttgtg 2070181 tcacagtggg tcaaagagct tcaggaaaaa tttttgattc cggctgttga acaaaagaaa 2070241 agctatgtgt gggagcaatg cgatattgtc gtctcatcaa tagacaccgc gaagcgctcg 2070301 ccccatcgag aaatcgttct gtctatccca tatgatcttg tcattattga tgaggcacac 2070361 aaactgaaaa atagcaaaac gaagaactat gaatttgtcc ggaatctcgt aaaaaaatat 2070421 tgcctgcttc ttaccgcgac gccaatccag aaccgtatcg aagagatttt caatttggtg 2070481 tccttattaa aacccggcca tttaggcagt cagaatcact ttcaggagga gttcgccaag 2070541 aagaaatcca gtttagaagc gcatgaacat ttaaaagatc ttgtgaataa agtcatgatc 2070601 cgtaacaggc ggcatgatac agggctgaat tggaaacagc gccatgttga aacagtgccg 2070661 attcaatttt ctccatcaga gcaggcgctt tatgatgaaa tttctcgttt gaaggacagt 2070721 atcaataaac cagccagcat gttctcgatt atgaccttgc aaagagaatg ctgttcgagc 2070781 agagaagcgg tatatatgac gctgaaaaag atgcttgatc aaaaagagaa acaagcacct 2070841 gccattgatg aggatacgat ttcagttttg atagatcgca tcaatcaagt gacacaaaac 2070901 tctaaagcgc ttcaagttgt tgacttgatc aaaaagatcg acgataaggt catcattttt 2070961 acagaatacc gcgcaaccca gatttatctg cagtggtttc ttcagcaaaa cggcatcagt 2071021 tctgtgccgt ttagaggcgg atttaaacgt ggaaaaaaag actggatgaa ggatcttttc 2071081 cgcggaaaaa tccaagtcct tattgcaact gaagcaggcg gtgagggaat taacctgcaa 2071141 ttttgcaatc acatgatcaa ctatgacctg ccatggaacc cgatgcggct tgagcaaaga 2071201 atcggaagaa ttcacagact cgggcaggag cgtgacgtgc atatttataa catggcgaca 2071261 aaacatacgg tggaagagca tattctaaag cttttatatg aaaaaattca tttgtttgaa 2071321 aaagtggtcg gtgaacttga tgatatttta acgaaaattc aagtgaacaa ttttgaagag 2071381 caccttcatg acattttgta tcactcagca acagaagaag aaatgaaaat aaaaatggat 2071441 aacttaacct catttttgtc ttataaaaaa cagctgcctg ctgaaaaaag aggatcttag 2071501 cctgtaagga ggttttatta gtgagacagc aagaggttca cgattttctg ctgcgttttt 2071561 ttcaagcaaa cagctgccaa atcgtcgatc aaggcttagg ctatatgaca gtgcagctta 2071621 cagttgaaat ggacaaacaa atcatgaacc gccctttcta ctggcattgg cgcgagaaga 2071681 caggcggtga tccgaatcca atgaaaatca cttttattac agataaagaa aatgcgccaa 2071741 aagacctaga tggtgaattt atatattttg gggccccgcg tctttttcaa atattcaaag 2071801 ctgttaaaca aaatgggaga tttaccagaa tgtatgagaa aattgaatca gccggagcta 2071861 aagtcccact tcagccttgg cttggtataa atgtcacgat ttcataccag tccgacatga 2071921 aaaaggataa gttattgtca ctaggtcttc acctagtctc tggaacgata attgaagatt 2071981 ttcaaagcaa gctgacccag ttttcactga cgtctcaaat atgtgactat tgcttcacca 2072041 tttcacctat gatcaaacca gaaagcggac ttaagcgtat ggaaaactat atttccaaat 2072101 ccgctatgca ggagccgtcc gactgggcgg aacaggcggt taacaggtgg aagaatgata 2072161 tgacattgct tgataagttt tacgagcata tagaagaaaa accagaagaa taccatctag 2072221 aaaaacaggc gctgaaaacc ttgtatcaac caaagatatc agttgaaatt gaaaatggcg 2072281 gattgtttta tctgcaaaat aatatttcaa gctaactttt ttaccattcg acatcattct 2072341 cgtttttttt gagaaaatac gattataata aaggtatatt ggaaaaaaat tctggtgatt 2072401 taatggcaaa tgacttccag agactaatga agcatacaat aagtcatggc cggactggct 2072461 gaaatacata aacaagtatt ttaggaggag aaactgcatg aagaatgcaa aacaagagca 2072521 ctttgaattg gatcaagaat gggttgaatt aatggtggaa gccaaagagg caaatatcag 2072581 cccggaagaa atacgaaaat atttactttt aaacaaaaag tctgctcatc ctggtccggc 2072641 agccagaagt cataccgtaa atcctttctg aatgtgctat aatatcacaa ggaaggtgat 2072701 gacattgatt ggccagcgta ttaaacaata ccgtaaagaa aaaggctact cactatcaga 2072761 actagctgaa aaagctgggg tagcgaagtc ttatttaagc tcaatagaac gaaatctaca 2072821 aacgaacccc tccattcaat ttctcgaaaa agtctccgct gttctggacg tctcggttca 2072881 tactttgctc gatgagaaac atgaaaccga atacgatggt caattagata gtgaatggga 2072941 gaaattggtt cgcgatgcga tgacatccgg ggtatcgaaa aaacaatttc gtgaattttt 2073001 agattatcaa aaatggagaa aatcccaaaa agaggagtag tgcctgagca gaggcactaa 2073061 ctcctctttt gtcaataacc atcgagacgg cccagtatat gaatactggg ccgtctcttt 2073121 tttttgctgt tattaatttt tatcctcgct atgcgcgagc tcgtcttgct cagtattgct 2073181 cattttttca attttttaga aatttttggg attgttatgt gagaatttaa atgcatatcc 2073241 cattattatt tggtaataat aaacaaagaa agggtgacag catgatgatc aaacaatgtg 2073301 tgatttgtct atctcttctc gtctttggca ccacagccgc tcacgcagaa gaaacaccgc 2073361 ttgtaaccgc ccgccacatg tccaaatggg aagagattgc tgtaaaagaa gcaaaaaaaa 2073421 ggtacccgct cgcacaggta ctgttcaaac aaaaagtatg ggaccgtaaa agaaaagatg 2073481 aagcagtgaa gcaataccat ttaactctga gggaagggtc aaaagaattc ggcgtttttg 2073541 tgacgatttc atttgatcct tatagccaaa aggtcaataa aattgccata ttagaagaat 2073601 atcaataagg tcctccattt tttgaaggac cttattcgtt tatttgcggt tattttttcc 2073661 gtttcagcca aagtcggaag ccatagggta aaataccgaa ccactgctgg gaaacaggcg 2073721 tttttgtttc tttccgcacc tcttttcgtt cttttcgctc atctctcgga gtatctatat 2073781 atttgacaaa ttgctgcgtc atatatttaa cataatcatt cgttttcacg tgatcacctc 2073841 atcattcaat tattatgagt gttgtctcac atgacttttt ttataccctt tacactgttt 2073901 tattctgtcc atctcagcag ttttttctgt ttttggtcaa acacgatctg tgcagttctt 2073961 tctgttcccg aatccgttga cactcttaag ttgatttctt tttgttcttt tatcgatgta 2074021 tcatgaatgt aataagaaac ccgtccatat agaaattgct gcgtaccctc ctggcctttc 2074081 cgttcctcta gaacatgccg aatcgaaaga agcaccccat tttgaagcaa attctctcct 2074141 atgtataact cttttgtttc cttctcaaac atgcagcgtg aaatatattg agcagcaaca 2074201 aagttcacga ttaacagcac aagcgctgac acaaaaagaa cagctggata aataaaccct 2074261 cttgtacgat acattcaccc ccctcctaaa tacgaataga ctggaaaagc agtttgatac 2074321 actttttggt cttcactctc aattttcagc aaaacaacac cattttcaat atcagctttc 2074381 atggcagtaa tatgatctaa aatcggaaca tgccctttgc catccactct ttttcttatc 2074441 attgaatgat aaatgtcaaa acggatgtct tgtccggaaa gattggtgca gattaacacg 2074501 ctcccatgct cggctgtctt aactgcctgt gattccttgc attcattcat catctgttct 2074561 atcgaaatca tccattcctg ctgtgtgaaa ccgtcatgtt cctgctgtcg agacaaaaac 2074621 agatggataa tcgcagctaa cgatcctgat atgagcaaaa agactgagag cgaaaataat 2074681 acgttaagaa gcgtgtagcc attctgtctg caaaatgctg aggcaaaatg atttttcttt 2074741 ataagctgcg gctttgatac atacgttttg atattcgccc tcctcctccc acttcattgc 2074801 atagatatga ttgttctttg taatcgtttt tgacgcggct ccttcaccac tcatgacata 2074861 tttgctaatg ctctcattca tcatctgata gccaatttct cgtgattccg ccattttttc 2074921 atcagccatc agcttgtccc acaaggggac gactgtcagc agcacaaaca gccacaggct 2074981 tagcgcagac attgtttcta ttgtagaaaa acctttattt tctctccaca ttgactctcc 2075041 cgctccctag ataaactgtt atgtcataaa cggcatggcc ttttactcgt atttttccgc 2075101 ctgcattcgg gtgccctttc tcattaaatt ccaaacggtc ttttaatgtc agcagttcta 2075161 tagaaagtcc cgttgcatac ggacgttcaa taaccgtatc accaatgact aattgatatt 2075221 cttttttatg aaagagaatt tttgttcttt gttgacggga aatagcagtc tgctgtgtga 2075281 gcataatatc atttttcagc tgacttgctg cctgtcggac agctgtattg tcataagcag 2075341 gaggaagtgt agtgaagacg gccaccagga ggatagaggc aaggcttaac acaagcaaac 2075401 tttctaaaag ggtaaacccc ttctcctcgt ttaatttaat gttcaacctt aacttctccg 2075461 ccggtgatga taatgcgctt accatttgga cagacagcat cctttttcac atagccctct 2075521 gactgtaaat cggcaaggct cggagtttgt ccttcatgat caagctcaaa tgcagtcatt 2075581 tgtgccttaa ccatgttttg taagccttca cagccctttt tttgaatggt ttgattatgt 2075641 ttcgtgacgt tcggtatcgt aattaaaagc aaaatcgaaa taataaagag cacgattaac 2075701 atttcaacaa gtgtaaatcc tttctcattc atcagcctct tcctttcaca tttgattcat 2075761 catctgatac ataggcacaa gcatagataa atacacaagt aagatcatcg ctgcaacaaa 2075821 tccataaatc attggctgaa ggatgcctgt ccatttttgc gctttgtgtt ccagccgctg 2075881 taatatgaat tggctgtatg tgaaaagctc ccgatccaat cggccgctca gctggccgtg 2075941 agatatgact tttgataaat cagtttcata aaaaaggctt ccacaaatag cggattcaat 2076001 tgactcaccg gcttttagcc gttcaatcaa ttgttcagcc tcgcagcggt agaaagggag 2076061 aaacgtttga tgtttaaatg cattaaggct gtcataaatt gagaggcctg attttaaaag 2076121 gctgcttagc tgcaaagaaa aaaagtagct gttaaacagc tttacaagct ttccaaccaa 2076181 aggaatcctg atacaaatca gcatttgccg ggcaggtgat tttttcttaa acacaagcca 2076241 ataataaatc ccgatacctg ctgtaaaaag aacaagcaaa atgatcacaa gatcaatatg 2076301 ctgaaaaaaa gcaaaaagca tatcggttga acgtgaggtt tccatattca tcgattgata 2076361 gataccggaa aactgaggaa tgatgatgga ctgtaacata taaaacatga cagcgaccgt 2076421 aaagatgagg aaaagcggat agcgcagcac tcttttcagc tggtctgcct gtgcaatttt 2076481 tcgttccagc agctctccgc tctggatcat tgaagcaggc agttcaccat gtgtttcagc 2076541 aaaataacaa atacctacgg cttccttatg aaatgacaaa ctctttagta cttgataaaa 2076601 cggagcccct tccctcaaac aagtgaccga atcagtcaag tcagccgcct gcctcttatt 2076661 catctgaagt tccatcaggc gtaatccatc cagaagtgta tatccgcccg cagtcatttc 2076721 accgagcctc tttaataacc tggcttgatc ctttaacaac cagacttttc taatcttttt 2076781 catgataaac ccaccggtca tagttgtttg tcgttaaata gccgagcgca attccttttc 2076841 tgataatttg acgaagcgtt tgatattggt aatttgcatg atttcctttt gcctcctgga 2076901 tacattgctg aagatttttc ccgtatagaa gctcataaac gctagctctc ctagtatttc 2076961 gtgactgtcg gcaatacact gatgaacatc cgttttcaca aaacgggcaa gccaaatcaa 2077021 ccaagcgctg agccgctatt gcaatgacag tctgttcgat ttcattcata ttgataccga 2077081 attcaagcag tctgtaaatt gcgccctttg cgtctctcgt atgaaggctc gttagtacca 2077141 gatgtcccgt catcgctgcc cgcaccgcaa tttcagctgt ttccgcgtct ctgatctcac 2077201 ctaaaataat catatcgggg tcatggcgca aaattgcttt cagacctgcg gaataagtta 2077261 caccggcttt ttcattcacc tgaacctgaa gaacatcttc gtcccttgtt tcaacagggt 2077321 cctctaatgt gacaatattt cgattaaagt gtttttttgc atattgaacg agagagtata 2077381 atgtggtagt cttccctgaa ccagtcggcc cggtaaaaat gagcatgcca tgggaatgtt 2077441 ttaaaaacga gagtaatgtg gctcctgtct tcggaaatag cgacaattta tcaatcgaag 2077501 ggatattgta ttggggcatc actctgatca cgaggctttc ttcattaatt gtgggcagcg 2077561 ttgacattct taaatgaaca tttccctctt tcaactttaa cgtaagcgaa ccgttttgcg 2077621 gctttcgcct ttcacctata tccattgctg aaagaaattt aaaatgtgaa atcagtctta 2077681 cgcactcttc ttttttcatg tccctttttt tcagcaaggc atgatcgacc cgaaaatgaa 2077741 tgatagcgtc ccgctccctc ggcacaatgt gaatatcaga agcctttgtt agatatgcct 2077801 cttcaatcaa gtttttgctt accttttcta ttgaatccaa tttgattccc tctcctttca 2077861 acgcatattg tagaaaaaga agaaaaggta atcaaacagg gaaaacgtga ttttgtgaga 2077921 tgttatatgc tgaaaaacca attctttctg gcaagaaaaa agactttcaa ctgaatgtac 2077981 ccctgtcatt ataattttcc ctataaataa aaaagcagac atggtcacca tgcctgctag 2078041 attccatttt cattatgctg ttttcgctta ttgaccagta tctttctcaa cggaaagatc 2078101 gcctaatgca acaataccgg tcatttggtc attttcaaga atcgataaac tgcggattta 2078161 atgctctgtc ataagcccct tgacatcgta tccggtcacc ctgatatgtc tggtgaaaaa 2078221 gcggggcacg ctgcacaaaa tatgaaacat cctatagagt ccgccttttt cgaggtttct 2078281 ttttcttctt ccgctcctgc agcatatctc ccgtccagcc tttttttctc aaatagagat 2078341 agatcagaac tgtagatgtg acaatcaata agagggaaaa gagatatccg tatttccaat 2078401 tcagttccgg catcactgaa aagttcatcc cccataaggc acccagagct gtaatcggag 2078461 taaaaagcgt cgtgaaaatg gtcagcgctt ttacaatttc attcccccta tgtgaggtaa 2078521 tgacttcctc tgaatgcagc agattgttaa gctccccttc aaattcgctg atgtatgtaa 2078581 atcccctgtc aatcttcagt tgtgtccgct gataatcctt tttcccttca ttttgaggta 2078641 aaaaggtttc tttcaacgcc atttcaattt ttttagcgct taatatcaaa tttttccaaa 2078701 tcatcagttc atggcgcagg agatggacgc ggtttaaaat gcttttgcta ttgtcgtctt 2078761 taatttgcca tctgagcttt ctcagcttga cttcaaattc atcaacaccg attaaatacg 2078821 cattcattag ttcgccgaga agaattaaaa acccctctat cgcattgtcc gctctttcca 2078881 tttgccgaac aacttctttg cctttaatct ctctcaaaat tgaaaagtca aagttgattg 2078941 taaaaaaata ttgtctggtg atataaaagt gaaaaacagt atggtctttt tcttcaccaa 2079001 gcccctgatc ataaacaatc gacccaaata ctgcttcatt ttccgtttca gttgtatcta 2079061 ctcgcaaaaa attaacgtga tggttatttt caaaccactt ttcacactga ggccagtgag 2079121 aaaaatggat tagatctctt gccttacttc tttcttgagg ccccatttgg taccaaaacc 2079181 aatcctttcc cgtatgtgcc ttcatgtcaa gctcctccaa acttttgttc tttattcttt 2079241 aattgcccaa taaccgcgtc actaaaccag tctgccgctt caacacatgt tttatgagca 2079301 ttttcaggtg gtatggaatg tagaaagaca tcggaaaagg gaggtgcatg ccttccttgg 2079361 agaaggcagt tgttttggaa tttatcaatt tactagcagt cgctattctc attttgttaa 2079421 caggattttt cgttgccgta gaattttcaa tcgtaaaagt gcggcgatcc aaaattgatc 2079481 agcttgtcgc aaaaggaaag aaaggtgcta aagcggcaaa gcatgtcatc actcaccttg 2079541 atgaatattt atcagcctgt cagctgggca tcacagtcgc agctttagga ctgggatggc 2079601 ttggggaacc gactgtgcaa actctgcttc gaccgctttt tcataaagca ggcttaaatg 2079661 aatcgcttac ccacctgctt tcactcgtca tcgcattttt agtggttacg tatttaaatg 2079721 tcgttattgg ggagctggcg ccaaagagtt tcgccattca aaaagcagaa agcattacct 2079781 tgttgttcgc taaaccgctt atttggtttt ataagatcat gtttccattc atttggctgt 2079841 tgaaccactc tgcccgattg attacaggag tgtttgggct gaagccggca tcagagcatg 2079901 agctggctta tacagaggaa gaacttcggg tcctattggc tgaaagctat aaaagcggcg 2079961 agatcagaaa aagtgaatta aagtacatga ataatatctt cacctttgat aaacgaatgg 2080021 caaaggaaat tatggtgccg cgaaatgaaa tggttagttt gtcactagat gaagactcca 2080081 tttcaaatct tcaggaaaca gtcaagcaaa caaaatatac acggtacccg gttgtaagag 2080141 aggataaaga taacgtcatt ggcgtgatta atatgaaaga agtgctgttt tccatgctga 2080201 cgaaagattt ttcaatcaag aagcatcaaa ttgaaccttt cgtacagccc gttatccatg 2080261 taattgagac gattcctatt tataaactat tgctgaaaat gcaaaaggaa cgcactcata 2080321 tggcgatcct catagatgaa tatggcggga cgtccggttt ggtcactgtc gaggatatta 2080381 tcgaagaaat tgtaggagaa atccgtgatg aatttgatgc ggatgaagtg cctcatatcc 2080441 gcgaacttgg aaaggatcat tacttgttaa atgcaaaatt attaatcagc gatgttaaca 2080501 gcctgcttgg aaccgattta tcagaggctg aagtagacac cttgggcggc tggtttttga 2080561 cacaaaacat agacgctgag cctgaaagtg ccatagaata tgatggctac tcttttaagg 2080621 taaaagacat caacagccat cacattttat ttatagaagt taaaaaagct gaatagcccg 2080681 tgaaaggctg ttcagctgct atctttcaag ataaacatgg caaaggcatc aacactcttt 2080741 tattttaaac cctttattgg ccagggcttt agcaagactt tgctctgttt tcacattcga 2080801 aaaatccaga cccagcttca cgacagtttg ggcaatttcc ggcctgattc ctgaaataat 2080861 agtctcaatg ccgagcaatt tggtgctgtc aatcacttta aaaatttgat aggctaccat 2080921 ggtatcaacg ataggaacgc ccgaaatatc taaaaataaa tacgagagct ttaacgctga 2080981 gcactgctcc agcacagact ccaaaatcgt cctcgctctg tgcgtatcaa tttcaccgac 2081041 aagcggaaga atcccaattc catcagtaat cggcataatc ggcgcactca attcattaat 2081101 catttctttt tgcgcgttta attgtatcat ggtcacctgg tgatattctt ccgtaaacac 2081161 ttcgatgatc tcatcaatgt tttgattcaa gatccggctc cactcataaa attcctgaat 2081221 gctgatgtct tgagaagaag cttcgctgaa tttatgaatc cattcaaaca tgatgtgcct 2081281 gaaagtgtta aactggccga cactttgtgt aaccgtcact tcatgaacgg cacggtctct 2081341 ggcgcattga agagaccacc ggttgagctc atcctctacg tcttcttttc taagggattt 2081401 tgctacgatg gtcaccaata attcatgctg gtcttttaac ttttgttcta gtttttgctg 2081461 atctttcgct gaatacagcc agctgccgtt tgacgtacaa acttccagcc attgttgcgt 2081521 aatatctttt ttgtgctctg ttaagtgctg atcaagagct atcatcttaa tgagttacct 2081581 cctgtttttg aaaaatgtac gctatatatg tataacgcgt ctgcctttac acatactatg 2081641 tttagattca atgggctata gccaagcggt aaggcaatgg actttgactc cgtgatcgtt 2081701 ggttcgaatc cagctagccc agtttctgaa caggtgaaaa accgaagata agctgattcg 2081761 tataaatcag cggatcttcg gtttttcatc atgcagattg atgaaccgtt ttcttcttcg 2081821 ataacttcaa cagttctccc gggttataac caatcaccag ctttttgttg tctactagaa 2081881 tcgggcgtcg caaaagcttc ggcttctcga ttaaaagttc cagcacctca tttaccgtca 2081941 tttcttcaat gtttaaattt aaatttttga aagtctggct tcttgtcgcc aaaatttcat 2082001 caattccttc tgtcgttaac gataaaatgt actttaattc ttctcttgtc ggggtttctc 2082061 tgaataagtg ccgttcgtta aattcaattt gatgtgcttt aagccaatgt tttgtttttc 2082121 ggcatgacgt gcagcttgga tatgagtaaa aagttaattg ttgttccatt cgttttttcc 2082181 tcctcagtta accatctctt tgtagaataa ctacccggat catttttcat ttaaaccatt 2082241 tacagaactt ttttcggatt attttttaaa aaacattcat acaatagaaa acacaatcaa 2082301 agggacaaat tccatttgta tattaataat gaaaatgttt acatttctag gtgtgatcta 2082361 ttataataac agtcagaggg actctcggga ggggataaaa atgaatcgca tgttccgggt 2082421 gttaggattt tggacgggaa tttttgcagt catgttttat ttaggtgata tgaaagatgc 2082481 ttccctttta ttttttggac agacgatctt atttgtgttt ctatcgtatt tgaacttaac 2082541 cgaacgcatg tatatttata tttttggcgc ttatttaaca attttcttcg ccggctttac 2082601 atattactca atttttatta tggtgcccgg cggcggaggc cattaaatgc agaaagagac 2082661 aaaccttatc ggtttgtctc tttttttaca atgaaaaccc atttaaaaac ggattttgat 2082721 cctgctcagt cagtacgtct gtttcaggtc catggccgct taacaccagc gtgtgttccg 2082781 gaagcgtaag cagtttttca tgaatggacg tcagcagcgt ctcttgattg ccgcctatta 2082841 aatccgtacg tcctataccg ccttggaaca agacatctcc ggaaatgacc aagtctgcat 2082901 ctttcacgta gtaagacaca ctgcctggtg aatgtcccgg cgtaaataat gtttccaaat 2082961 gaaacggccc gatattcaac tcaccgtcgc cttcaattag atgatctgca ggcttagctg 2083021 tgacttctat ccctcgcagc atgccggagc cgtttaaaga agcgtccgca agccaatttt 2083081 tttcattttg atgcaggtaa acagggatat cccatttttc tctcacttca tcaagcgccc 2083141 caatatggtc aaaatgggca tgtgtaagca aaatggctaa aggcgtcagc cctttttctt 2083201 ttatgtattg attgatttta tgtccctcgc cgcccggatc aaaaatcaga cattgatcat 2083261 cactgatgag aaaatatgcg ttcgcttgaa tcggccctac tggcattcgt ctccatttca 2083321 ctattatcac ctctttcttt tttatgctct tattatgagg gtttttgaaa aaagattcaa 2083381 acaatcgcaa tgaaaacgct atcgacaaac ctataaaaaa caggtagaat aaaactggaa 2083441 agaattgcag gtttttcaat gtaaaggggg ctgtgttatg ttacttgtcg tgattttcgg 2083501 ccttgtcgct cttttcgctt tatggggagt cttgcgttct gttagaaata aaaatatact 2083561 cgggttttta ttagccggtg ccaccttatt tgtctttgga tggtttaccg tgatgaccgt 2083621 aataaacagc gggtatccaa ccgcacatta aaacctgtat ccgatcggat acaggtttat 2083681 ttttatggct gtaaatgttt attgacactt tctattttgc tctcaagcgt cgtttttttg 2083741 tcacgcctgt catcgatacg gatattcgtt gccactctgt gcaatccttt ttgaaatggc 2083801 gcttcgtgaa ttgcctgaat aactgcaaaa aggtcactga gttctccctc gatcagcgta 2083861 ttcatcggtg tcagctgata tttgattttc ccttctgctt gatatccttc taatatcttt 2083921 tgcacatcgg ctacgtaagc actgacactg ggtgtttccg taccgattgg gataatggtt 2083981 acatctgcga tagccatcgt tattccatct ccttttgatc aatgatgagt tgcttcgttt 2084041 catgtgattt caataaaata atttgctcaa aatgaaagcc gtataacgca tatttcccgt 2084101 tcggagatat ttgaatcggc tccatttccc gcagagacac aagatctttt gtctctcccg 2084161 atgctacatt gattgctgcg agcttatatg catcgccgct ttgtttgaat gtataaaaca 2084221 ggcctcctgc ttcatcatag tcatactcca ttggagccaa acttgtatat ttcgcttgga 2084281 gcggccattt cgctgtaaca ggtgatgttg attgcggcgt tttaaactga tacgtccctt 2084341 ttcctccgga agctgatttg acagtaaaac tcatttgatg gaaagaatcg aagaatagaa 2084401 cgttatcctc aagcttctgt tccgtcttag aagctgtatc gaacgtatat aaaggccctg 2084461 ttttatcgtc tctaccctct tttacataat caaatgtatt tttggatgtc caatgaatga 2084521 acggaacctg tactgggctt aagaaagatt cgtctttttt agcattcacc tgatatgtat 2084581 ggaaatccca gttttcattg aattccgtca ccatcatttg ataaggatca tactgattcc 2084641 aagcagcttc aagctcatac gtttcgtaat ctttttcgta aagcgtctct ccttctgcat 2084701 taagcaaaac cactgccgtc ttttggctat gtgtgatttg cagcagaatc atctgctccc 2084761 tcgcattgat ttgaacatca acgatttgac catccgtttg atagagcttt ttcgctttgc 2084821 ctgtaaagat gcggtacgca aaaagctctg ttttcgtcgg attagacgca gtatataata 2084881 ttgtgctgtt attcagccag ccttccgccc catccgcttt ttccgcggaa agcggtatga 2084941 tgtctttttt ctcatctttt gccgccgatg cctgtttttg ctgctgatga gatggttcgc 2085001 atgccgataa actaaacagc aataccgcca gcagaataaa acaaactgat ctcatcagca 2085061 ttcccctccg atcatcttta ttctctcata tttgcttcgg cagaaaaaag aaaaagtttc 2085121 agttactcat gaaaaaataa cgccctccac aagataccgc ttgtggcgtt atatatgtgt 2085181 gaaaactgct gaaacggcaa aggattttgg ccttttccaa gttccaccgt atacccttcc 2085241 ttaaaataat ggtgaataaa ccaatcacga aatccagcat agctgtctat atcccttact 2085301 cccttataaa tgttcccgct taactcctca aactccttta tgacggcagc agattcctca 2085361 ggctcaaggc ctttatagcc ccaataaatt tcttctcctt gagtatgaag agccagcagt 2085421 ctgtcaggcg gattctccgt gatcagccgg tacatcgcaa tagattccgg ctccgtaagc 2085481 ggagagattc ccggaaaatc gcggtagctg ggtgctgtcg gttttcggta tttttcaatt 2085541 tcccataatg atggaaattg tttatttaaa tcaaccccgt ttatattcgc cttccattca 2085601 ttaaaatttg gacgatgttc atttagcctt tcgagttcat ctcttctggc tcccatgact 2085661 tctgatccgt ttaaaacaag atcaacgcca tccggattga caagaggaac gagggataag 2085721 gatgtgctgt taaacagctt tatgggagaa aagccaaaga aaggcgaatt gcagcataat 2085781 gacatacagt attccttaaa ccattttagc aggacagacg ttgtaatcca ctcattcgca 2085841 tgaaatgacg cgttcatatg gacctttttt acggcatgct ccccaccagc cttcagctcc 2085901 cagataggcc tgccgagtac agaacggcca atttcccggc atgagacaaa cggaaaaaca 2085961 tcaataatct tctttatttc cttttcaaca gctgaatcat catagatttt ctcttgctca 2086021 atccagctat ctgaaagttt cagctgccga ggctgtaaaa agcgctttat gtcctgaatg 2086081 gtttgaagct ctttgccgct atgctcctct atcacataac cagggcaata caattgatgt 2086141 ttttgtgcgg agcgatttgc acttttaagc aattcctcgt ctatcttcag ttctttcgcc 2086201 acattggcca aattgttctt gatctcaggt ttcaccgtaa taaacgccat catcatcccc 2086261 cttttttgtt actatatgac agcgtattta aaaaaagaaa gcctcccgct cacttcgatg 2086321 cgggagacat tgtgattatg atgcctgatc aagcatttgt ttttctttcc gctttgacga 2086381 attgtccagc cttttctggt cataaaatcg caacaaatcc ccataaatga tttcatcaga 2086441 aagtgatagc tcctgttttg ctttatcagc aaatgcttca cattgttttg tctcttctaa 2086501 cggttttccc gtctctttgt cataacacgc accgtctgta taaacaacct gatctgtgat 2086561 aaagctcccg tcccggagca ccgtgaagtc cagtttttcg tctgaaagca gatcgttgcc 2086621 gaattgaatt tgatctttcg tatcaatccc taaaagattc atcagcgtcg gcctgatatc 2086681 aatctgcccg cctactgttt caatggtttg cggcttttta tcagtaatac ccggaatatg 2086741 aatgaccagc ggcacttttt ggagctgtac ctcttcaaat ggggttattt cttttcctaa 2086801 aaactgcccc atcgcttcat tatggttttc tgatatacca taatggtcac catataatac 2086861 aataacagag ttgtcgtata acccgtcttc cttcagcttt tcgataaacc gtttcagcgc 2086921 ctcatcctga taacgcactg tcggaaaata tttatttagc gtctggctgt ttgaatcata 2086981 ttcatcaatc aattgatcct cttcatcaag atcaaacggg aagtggttcg tcagtgtaat 2087041 cagcctcgag taaaacggct gaggcagatt tttcatcagc tctgaggact gctcaaaaaa 2087101 ttctttatcc ttaagtcccc agccgactga attttcgtca gttacatcat acgagttaat 2087161 atcaaaaaac gaatcatatc caaatgagtc gtacattaaa tcacgattcc aaaagctctt 2087221 attattagcg tggagcaccg ctgaatagta tccgctgttt ttcaaaattt caggagcggc 2087281 catatattga ttgcccgcat tcgtaaaaaa tacggcacct cgtccaagcg gatacagtga 2087341 attgtccacg ataaattcag aatccgaggt tttcccctgg cctgtttggt ggtaaacatt 2087401 attaaagttg tagctctgtt ttataaagtc attcagaaaa ggcgtgattt cttctccatt 2087461 caatttttca ttaatcacga agctttgcgt cgactctaag gatacgagaa tgacgttcct 2087521 tccttttgca gcgccgaata agcgtttgtt ggcatccttc gcattagcgg ttacgtagtt 2087581 ttcaatctcc gtcaggctgt tgctgtctgc caacgctctc tgtgcggatt gctttgactg 2087641 aagaacgcca tcgtaaatat gaaaattaaa caggctaatg tttttaacaa gcatttctct 2087701 gtcaaatgag cgtgtcaata gctgaggtct ttccgcctca gacaagccca ggttgaagaa 2087761 ataaacagaa gcaacgaaca aaaaataagc cgcccgttca tttttcgttg agggaatgtc 2087821 cgattgaaaa gctttttgcc ggatgtgaag ccatattaaa accgcaatat ctacagctaa 2087881 taggaggtct gtcggctcaa gaagtgttcc gatgctgctt ccgagatcac ccatattgct 2087941 cgtttgaaaa agaacaggga ttgttaagaa atcattgtaa aaacggtaaa aaaccatatt 2088001 tgccagcaat acaaacgtga caagacagct catcgcgata atgtagcgat ttctgttttt 2088061 gccttttaaa aacaggctga ggccaaaaat aagcaacaaa aaactcaatg ggttgataaa 2088121 cagaataaat tcctgtgtta gattgtcgat tttaatatga aaactggttt tgtaaacagc 2088181 atacgttttc agccacatca ataaaatggc aatcagcata aatgaaatct tcgaaaaaaa 2088241 cgtttttcgc atttcaacct cctatgcagc acgctcaaaa aaatcagtct attcccaaca 2088301 ttctcattaa cacatcaaat taaatcttaa cctgagcaca acaaaaaatc aatttcattt 2088361 acacaatttt aacaattttg atgtttcagc cattcatttt tagcgatcca agcgcctccg 2088421 ataacgccgg catcatttcc aagtgctgcg attgaaatat cagcagcttg ggctgcccgc 2088481 ggaaacgcgc atttgcggaa tgttttctcg acttttgatc tcagcagttc tccggctctc 2088541 gatacgccgc cgccaagaac gattttggat ggattaagcg agcttgccaa atttccgagc 2088601 accaaaccaa gatgcttggc tacataatca accacctcaa gggcaatttc atcattttca 2088661 cccgccgctt caaacacatc tcgcgctgac aattgttcgg ttgcttttaa acgtgtcgtc 2088721 tttttagcat ttgctatttt ttcttttgca attcttacaa ttccggttgc tgacgcaatt 2088781 gtttcgatac agcccgtttt gccgcagttg cagggcgctc cgccttcagg gatgctgcaa 2088841 atatggccga tttctccgcc ggcgccattt ataccatgta caatttcacc atttgcaatg 2088901 atgccgccgc caactcctgt gccaagcgtc acgagaatga cgtcttttgc gccatcaccc 2088961 gctcccttcc acatttcccc gagcgcagca atattcgcgt cattttctat aacagctggg 2089021 atgccggttt ctgtctccag atggtttttc aaagcataat ttttccaccc tagatttact 2089081 gtttcataaa ccactcctgc cgccatatct acagggcctg gtgcacccat tccgatgtat 2089141 ttgatgatgt gcttcggttt ttgcagctca tccagcttgc tgtcgattgt ttttgcaatt 2089201 gtgacagtaa tcgtgtcgcc ggttttatct gtcggaactt cccacttatg ctgaatttcg 2089261 ccatattgat taataaaagc gagtttaatc gtcgttcctc ccaggtcaat gcccgcaaac 2089321 catatctcgt ccatttttat caccttagcc tttataaaaa tctcttccgt tttttgtttg 2089381 ttccaattct tttcgaagga cagctgccgc tctggcccac tgctcctttt caatcatgtg 2089441 gttcatgtat aattccttta attcatccag cataaactca atttcaagct ctctgtctcc 2089501 aaaataaaca atgtggccaa acgtttttaa cagctgctgc acatcataaa atgtattcat 2089561 tttcctcacc atttcttgaa cttaactatc ataagcgtat tcataaggaa gcggtcagtc 2089621 aagaagaaaa cgctgacaaa aaagccagct tcctttccat attccacctc tatgattctt 2089681 tattgttttc aatttgccgc tgcagctcct tgtagcgctg ctccttcggc ttcagtttca 2089741 cagccgtctg gatggccttt tctgcttgtg caagctcatt tttttccgca tacaataacg 2089801 ctaaattgta ataggaagca tggtctttag gttctttttt cactgctcgt tccaaaaggg 2089861 aaaccgcctg atcatattcg ccgatttgaa tatcagaaac agcaagaatt ttcaaaagat 2089921 cggcagaggc atctttttgc gctgcttctc cgttcagcaa ttctgttact tcttcatact 2089981 ttccttcctg atacagctcg cttgcctgct gaatcagcgc tgactcctgg tgtgaaggcg 2090041 aatgcaatcc gtaatataaa aatccaacag ccaaagcaat cagcaaaacc gctgacaaca 2090101 atctttttcc aaaggctccg gctttaggca accccagtgc tgctgcagcg aaaaagccgc 2090161 caatcaagcc gccgatatgt cctgaattat caatattcga aaccgcaaaa ccaaagccca 2090221 gattgatgat aataatgaca ataatattgg ttcctatagt tcttaaaaac atttttcgat 2090281 tagacaaagc aacatacagt aatgcaccta agcatccgaa tatggctcct gatgcccctg 2090341 ccgaaggata cgggctgaac acaaaactcg caatcgaacc cgtaatgcca gcagccagat 2090401 aaatcagcaa aaatctcccc gatccataca tccgctcaac cgctgtacca accgaccata 2090461 aagccagcgt attaaaagct aaatgcgcta tgccgatgtg aagcacgatc ggtgtcagaa 2090521 gccgccacca ttctccttgt gcaatcaggc tgttttcttt tgctccaaaa gccaccagtg 2090581 tctccgtatt agtgctgcct ccgtttattt cgagcaagaa aaacatcagg atctgaagcg 2090641 caataaataa atatgtaaaa gtcggttttc cgttttgaaa aaccgccgct tcagtttttc 2090701 tctgttcttc ttgtttcagc actagcgaaa ggaagcgttc tcgcgccatt tgcgcgtttt 2090761 caaacgaagc gtgttcctct gaacaatctt ctgtacgaaa tgatggaaaa accgcttgaa 2090821 gatcatctcg aagcatcgtt cctctaacga tcgccggctc aactgacaca gttcccttct 2090881 caaaagtttt ttttgcaatc tcttcccagt catcaactgg ggcttccgtt gaaaaaaaca 2090941 cgttcagcag cttcatcctt cgtctgccca attgatgtct gactcgttct actcgttcgg 2091001 cctgctcttc gatgtctcta accatttctt gacggaaatc aagatcgtgc ttataaagac 2091061 gaactagatc atgagaggac ttgtccggcg cttccagcca tatttcatct gactcaccgg 2091121 cttgtatgac gccatacccg ctattcacca ggtgcgccgc aattttccaa tatgtatact 2091181 ccagcaaaaa catgtttacc gctccaatag ttttttttca ttataacagc tggcgctccg 2091241 aaacgcctac tgaaagcaaa aaatcccgtt tttcacggga ttttagaaag cttgctgtat 2091301 aaacttattg cggataaatg gaattcttaa aaacaaatgg ataaaagacc gcctgattcc 2091361 tggctggctg agtacagtat tcataagacg gtagcgattt tgataaaaca tgacggcaga 2091421 aaccgcgaaa atggcatata tcaaaagttt tttcatgata tccctcctgc caatagggtt 2091481 tgttattcta ccttatttat tctcgaataa gggacaggaa agttatgaaa aacaagaaat 2091541 aatccgatcc tctgttatca gcttatgtac cgggatgtca tgcggcagac ggggtacgtg 2091601 cgcaaacaac tggcactcca aaagcaaaga gactgtcttc ccttcatatt cacttaaata 2091661 gcgatcataa tagccgcctc caaagccgac cctaaacccg ttaacatcaa aacaaacacc 2091721 cggaacgatc atcaagtcaa tttgtgatgg gtttacttct tttgtttttt caattaccgg 2091781 ctcgagcagt ccggcgtaca cggtttcgag ctgatcatca gtctgatatg tgcgaaattg 2091841 cattttcttc gtgtccggat ggcattttgg gatgcaaact tgtttccctt cttcccaagc 2091901 ctgctcaatg acaggacgcg tcggtatctc taatcctctg gaaatagtga cggcaatggt 2091961 gccggcattt tgccactccg gcagagaaaa caagtactta tacatacgtt ccgttttttg 2092021 aagaatatct tcatttgata aagcagacag tgcctccagc gtcttttttc ttaattgtga 2092081 tttcatctct catccccctc ggaatagaaa aaaagccaga acctttttca aagctctggc 2092141 ttttttctta cacctcaaac agcaaagctg ttattttgtt tcacggtgta acgtagattt 2092201 tttatcacgt gggcaatatt ttttaaattc aacgcggtct ggattgttgc gtttgttctt 2092261 tttagaaata tagttacgct caccacattc agtgcaagcc aaagtaatat taacgcgcat 2092321 tattttccct ccaaactaaa atcatttact tattcagact tatatataat accactataa 2092381 tggacggaat gctaggctgt ttttcaatga attgctgaat tattgaagat acgctcataa 2092441 agctgcaaat atgatgacat aatgagtcgg gggtggtgga gcttgaacac ttgttgtctg 2092501 ccagcttctt ttatccggcg ggctttttcc cggtctttta aaaaactgtc cagcagatca 2092561 gcagcttcct gtacgagcgt aaaatcagcg atgattgccg ttttgtcatg aaccgcataa 2092621 tcacaaaaac cacctgactg agaaacgaca gtcagcacac cttgttccat gctttcttgc 2092681 gcggcaagcc caaacggttc ataagaacta gggaaaacag ccatttcaca gtgagacagt 2092741 aacgttctga tatctttcct atttagaaac ggcagaaaca tgacgcgatc cttcaggtta 2092801 tatgccgcag ccaatttctc atagcaggac agagacggcc cctccccagc cagcactaga 2092861 tagaggtcag gctgacgctg cttcaagatg gcaaacacct ttaacagctg cgataatcct 2092921 ttttccggaa caaaccttcc atatgaaaag aggaatcttc tattcatgct tctcgggatt 2092981 ttccccttct cttcctccat agatgcaggg cttgggataa cggttatttt cttatgtgcc 2093041 gccttatcaa gagaccgctt cataaatgtg cttaatacga tcaatgcatc agcggattct 2093101 ataaggagcc gttcggtcat gagcctgtat gggtgtgggg cttctcggca caccttcttc 2093161 ctttcgcttt caagaccgtg gattgtcgca gcaagcggaa ggccaagccg ttgtttcaaa 2093221 tactgggcgg caggggcagt tgtgtcatca tgggcatgaa tcagatcaaa gcgtttattg 2093281 tgtgataaca catggcgaac cattgtaaag ttagcatcag ctatgtaatc ttcaaacttc 2093341 gcatacgaaa acagctgccc gctcggagta aaaaccgtaa tgttgatatg agggtttaaa 2093401 taggaaatga ggcggtttaa atggacaccg agcccgcttt tcggctcatc gggatgttcg 2093461 ggtgaaagca tgagaatgtt caccgttctt tttcccctct cccataacag gtgtatgcag 2093521 aaaattgcgc ctcccacctg gtgtgcgctt cttcaatctg aaaactgttt atatgacgaa 2093581 tcccattttc atcaagatag atgtcgtctg taccggcaag cttgagagag acattcattg 2093641 aattcacaat tctgtattca gcccgatata cagcatcacc agccgcctgt ctaatcgtcc 2093701 attctccttt atcatacgtt gtgcgttttg tcctgacagc ttcaatgtct tttcttttga 2093761 tgacaatgcg caattctttt atcatatcct gcgttttttc gaaaaggacc gcttcagcca 2093821 gccgcattgt ttcttctgag atttcccagc ttacggtcaa ggtgtgagcg ttttgaatga 2093881 ttatgtcgaa tgtgtcccta aaaaaggaaa gcttatgtcg tatattatag ggaaatgggt 2093941 gtttatccat ggactcctaa cattctcctt tccaatcgtt cacttcgtgt tcctattaaa 2094001 ccattacatg aagaagaagc gaagaaagat ttctcgacaa aatctcgttt ttttcgcgaa 2094061 ttcctttaga aactattggt tttatggtat aaaaaagaag gataaaaaaa gaatagaagg 2094121 tgatgaaacg tggaaattgc tattattgcg ttgtttatcg tcagtatagc gctaattgca 2094181 ttctcatatt ctcaaagaga cccgatgaaa gatgtagaac aggagctcga aacactgcag 2094241 ctttctgcga tgcaggaaat ttacaagctc aaaaagaaaa tgacagtgct tgaggaagaa 2094301 ttactggaaa caaaccttgt cattcgcaaa tcaaagcaga acgacatcaa tcaaaaaatc 2094361 gctaaacaaa tactttctaa atataataac ggtatgtcag ctgaagcgat tgctaaagct 2094421 gaacatgtat cagtggaaga cgtgaatacg attatcaaag ataatgagaa ggtgctcgta 2094481 tgacaaaacg gggcattcag gcatttgctg gcggcatcat tttagcgaca gccgttcttg 2094541 cagctgtttt ttatctgact gacgaagacc aggccgctgc tgtaaaagat aataaaacag 2094601 taaccgaaca agacgtgaac aattatcttg attctaaaaa attggtttct gtcaaccgtg 2094661 atgaatatca aaaacttctc gattcaaaag agaaatcctt aaacaatgac agcggctcag 2094721 acacgaaatc agacaaagtc aaaacctaca agctcaccat taaagacggc atgagcacgg 2094781 cggatgtatc tgctattctt gaaaaagagg gcattatctc ttcggctcaa gactttaatg 2094841 actatgtcat tgatgccggc tatcacaaag aaattcgtgc cggcgagttt aaagtaaaat 2094901 cagacatgag tttcaaaaag atcgtaaaaa cgttaacacg ataaaaaaac aggctgactc 2094961 agcctgtttt tttcatccaa actttcctga aatgtaatcg agcgttcttt ggtccttcgg 2095021 gttagagaac attttattcg tattgtcgca ttcaacaagc tcgcccatgt agaaaaaggc 2095081 ggtttgatca gaaacccttg ctgcctgctg catgttatgc gtgacaatga caattgtata 2095141 tttatctttc agctctagaa tgagttcttc aatttttctc gttgagattg gatctagtgc 2095201 agatgtcggt tcatccatca gcaaaatatc aggattggtc gcaagtgctc tggcgatgca 2095261 aagacgctgc tgctggcccc ctgacagcga aagagcggac gtatgcaatc gatccttcac 2095321 ctcatcccat aacgccacgt cttttaatga cttttccaca atttcctgaa gcttcttctt 2095381 atttttggtg ccgtggactc tcggtccgta agccacatta tcaaaaatag attgcggaaa 2095441 cggattccct ttttggaata ccatgccgat attttttcgc aaatccacga tgtccacttt 2095501 atcctttaaa atgttgctgc cattatagtt cagctcacct gcaagcttta cattcggcgt 2095561 catttgaatc attaaattca atgtcttgat aaaggtcgat ttcccgcatc cggatggtcc 2095621 gataatcgcc gtaacctcat tttcataaat gctcaaattg atatttttta aagcatgatg 2095681 ctgcccatac cataagttca ttccattgac ttgatatact tcctgtttca ttacagcttc 2095741 ggtagcaata ctcattgccg ccctcctatc cgaatttccc gttaatataa tcctctgtct 2095801 tttgcttttt cggactcgtg aaaatctgtt cggtctgtcc gtattctaca agctcgccgt 2095861 ttaaaaagaa tgccgtccgg tcagaaaccc gcagagcctg ctgcatattg tgcgtgacaa 2095921 taataattga gtattctctt ttcaatcctg taattaattc ctctattttt gcatttgaaa 2095981 tcggatcaag cgctgaagct ggttcatcaa gcagaagaac agccggcttc atcgcaagcg 2096041 ttctcgcgat gcataaacgc tgctgctggc cgccggataa cgagagtgcg gatgaatgta 2096101 aacgatcctt cacctcatcc cagagcgctg cttttgttaa actttcttcc acaatttcat 2096161 ctaaaacagc tttattccgc tctccggcat atttcaatgc atgtgtgata ttcgcataga 2096221 tcgatttcgg aaatggattt ggtttttgga aaaccattcc gatttctctt ctcaagctga 2096281 caacgttaat attgccgccc aatatattta atccctcata aaggatttca ccttccgctc 2096341 ttgcagatgg aattaaatcg ttcattcggt taatatttct caaaaaagta gattttccgc 2096401 atcccgacgg cccaattaaa gcagtcaccg catttttttc aatatccatg tttacatgat 2096461 gaacggcttg tttatttccg taataaatgg acagatcttt gacctcaagc acgtggttct 2096521 gcttcggaac aataacagct cgctcaggtt tttcttttac catttgttca gacatgtttt 2096581 tcgcctcttt ccgttctaat ttgccgtaag ctttttgtag atcatcgtgc caagccatct 2096641 cgccgcgaga ttaaacacaa gaacagaaat caccagcacg gcagaaccac cgttggcaat 2096701 cgcttcagca tccggaatca ttccttgtgt attgacgttc caaatgtgga ccgcaagtgt 2096761 ttcagcgggc ctgaaaatat taagcggtga tgtttccgaa aacgggttcc actccgtaaa 2096821 attaagacgc ggtgttgtca ggcctgccgt aaataataat gcggccgctt ccccgaacac 2096881 ccttcctgac gctaaaattg ctcctgtgat gatagaagga atcgcacttg gaattaaaac 2096941 tgtttttacg gtatgccagc gtgatacacc taaagcgaga gaggcttcct tcagatcttt 2097001 agggactgaa cggatcgcgt cttctgtcac acgcaccatg acaggaaggt taaaaacagt 2097061 taacgcaagc gctccgccta tgatcgtata accccagcct gttaagttga caaacatcaa 2097121 taatccaaac atcccaatga caatagacgg aagagatgaa agcacctcta tacatgttct 2097181 aatgaagtca gttactttgt tattaggcgc gtattcagcc atgaagactc cgccgcccac 2097241 accgagcggg attgtaatca gcattgtaat aaacaaaata taaaaggagt taaacagctg 2097301 atctcgtatg cctcctccag ctgcaatggc gctcgacttt gttgtaataa attgaaaact 2097361 gagctgagaa acaccgttta taataatata ggaaaacaaa cctactaaaa tggcagcgat 2097421 aatggctgca cacaaaccaa acattccggt cgccagttta tctgttattt tgcggttcat 2097481 tacactttcc tcctagatga caagtagcga ataagcagga tgaacaagaa tgacatcacc 2097541 agaagcacaa gccccattga ccacagcgta ttgttttcaa cacttccgta tgtggtgtgg 2097601 cccatattca gcgtgatgat cgttgtcagc gttcccgcag tgtcaaacgg gctttccggc 2097661 aatactcttg tatttccaat gaccatctga acagccaaag cttcaccgaa cgcccgagcc 2097721 atgcctaaca caacagctgt catcaatgtt ggaaaagctg caggcacaag tacttttctg 2097781 atcgtctgcc atcttgtggc accaagcgcg taagaaccct ctcgtaaact cttcggaaga 2097841 gaagccattg catcagcaga aatcgatgtg atcgtcggca gaatcatgac ggaaaggaca 2097901 atcgttcccg ccaataaact gtgccctgtt ccgctcgatt tgaactgggc gataaacggc 2097961 accaatactg taagacctat gaatccataa acaacagatg gaataccgac taaaagctca 2098021 atcaccggct gcagcacttt ctttccccaa ttcggggcaa tctctgtcat aaaaatcgca 2098081 cctgcaatgc caagcggcgc agcgattaga gcagaaagaa tcgttactgc aaatgagcca 2098141 aaaataaatg gcagcactcc gtatttcgga tcactatctg taggattcca atttaagctc 2098201 gttaagaatt caattgggct tacaccattt acaagaaaag attgcagccc cttaacgccg 2098261 aggaaaatgg taatcgcaac agatgccgca atcataatca gtgcacaagc tgtgactatc 2098321 attcttcccc gaacttcatc caattgccga ttttgcctag agctgattaa gcgctcgctc 2098381 acagacatat tttctctatt gtttatcatt gttttacact cctatgaatg tgttaagagg 2098441 agaaacggtt gtccccgcac tcctcttttt attaagatca gctttgcttc ccgttggcat 2098501 cacgtgtcac tttcatatca gtaaccggaa tgtagccttg gtcagtaaca atgctttttt 2098561 gaatgtcttc actctttaga taatcaagaa attctttagc taaacctgtc gcttcacctt 2098621 ttgtataaga atgttgataa gcccagatcg gatactcgcc agttgctaca tttttcgctt 2098681 caggtttaac accgtcaata gatagagcag ttactttgtc atctgttaaa tatgagaatg 2098741 caagatatcc aatcgctccc ggagtatcag caatgatctt tttcaccgtg ttggaggaat 2098801 cttcagtaat gccttctgca ggctccgctc cgtcaagcgc atatttcaca aatgtagcac 2098861 gtgtgccgga agaatcaggg cggtttacaa gtgtaatctt ttggtctttg ccgccgagct 2098921 ctttccagtt tttgattttg ccagtgaaga tttttttcaa ttcatctttt gaaatatcct 2098981 ttacaccagc atcagggttt acagctgctg ccataccaac tacagcgact tgatgatcga 2099041 caagcgcttt tgcatcgatg ccttcttttt cttcagcaaa aacgtctgaa ttcccgatct 2099101 gaacagctcc ttcagagact tgagaaagcc ctgttccaga accgccagct tgtacctgta 2099161 tatcagcatc agggttttct tccataaatt tttccgcggc tgcaagtact agtggctgca 2099221 ttgccgatga accagaaatg gttaaagaac ctgatgcctt ttcttctcct tttgcagaat 2099281 cgctattcga ttttttactt tctcctgcat ttccgcatgc agctgcaatc atcataaaag 2099341 cagccatcag aagcataagc accaatttgt tttttttcat ttcctgaatt ccccctgcgt 2099401 ataatgtgta atttgtccta cacgtataga gtaaaggttc tatgtaaaaa gggtttgaac 2099461 cgaatgttaa ggttttgtaa atcagtgcgt ttttttgtat aaaaaaaacg cccacatcat 2099521 gtgagcgttt ttttttagtt atcagaagac gttgtgtttt ctgcattttc ttcaattttg 2099581 tctttattct tttgctgagt accttctttg tcctgcttcg atttcagctc aaaatattta 2099641 tccattactt ccctgccgat ttcgtttgta attgagtatc tttgattgta atcaatgtaa 2099701 gtccaaggaa ctacgacaga aatagcaatc tcaggattgt cagctggtgc ataagccaca 2099761 agcgtcgtat tataagtgtc tgttcctgtt tttgatttat ccggtccgtc gtaaaatgat 2099821 tgggctgttc ctgtttttgc agctggttta tacgatgctg aagccagttg acctgcagct 2099881 gtccctttag tggcaacccg tctaaaaccg gcttggacct cttcaatata gctactcttc 2099941 atatcgactt tattcaatac ttcaggctga acagaatcaa cgactgcgcc gatccctttt 2100001 ttcgcatttg aatctctgac ttcctttaca agctgaggct tcatgcggta gccaccattt 2100061 gctatggtgg agacatattg agccaattcc agcggtgtat aagtatcata ctgtccaatg 2100121 gcgaaatcaa gcaagaaacc agataatctg cttgtacctt tatatcccgt catttcattt 2100181 ggtagatcaa ttcctgtttt tactcctaat ccaaattgac tgaaataatt tctgaaggta 2100241 tcaaatgcag aagtatccaa aggcaatgct tggtgaggtt tatattcacc tttaccaact 2100301 gcaattgctg ttttaaacat aaaaacgttt gatgacttct ctaatgcagt ttgaatacca 2100361 accggcccta agttttgcca agattttttc cctcttttat cctggccgat atacaatggt 2100421 tcatccttaa atacagtatt caaattaatc gctccagttt gaagaccggt caaaacggtt 2100481 gcacctttta cagctgatcc catagcgtag gatgaagtca tggctcctaa tgcataatca 2100541 tcaaacttat aggctccatt ttctcgttta atctgcttcc ctgccattgt cagcacttcg 2100601 ccgtttctag ggtccatcat gacaacgaat gcacgatcca acaattcggt actaggtctt 2100661 gctttagcag ctttaagttt tttctcaata attttttcca ctgatttttg caaatcaata 2100721 tcaattgtta gtacaagatc tttcccggct ttgccttcag ataccgtttt tgttcccgtg 2100781 acattgcctt ttgaatctgt gatattttcg acttttgctt tttggccctg cagaaggctt 2100841 tcatattggt attccagata gctttttccg accctgtcat ttcggctgta gccaagcgac 2100901 agataatggt cgagcaagtt ggacggcaat ccttcattag agctggaaac acttccgagc 2100961 actgagcgaa gaaggttttt ataaggatat tcacgttccc aatcggacgt gacatcaaca 2101021 cctggcagtt cgtctaaatg ttcacttacc actgccattt ccttcgctga tacatcttcg 2101081 tttttgatat attgaggggt caatgcatag cccgaatcca tctgtctttt gatagcaagg 2101141 atctgcatat ctttatccgt caattcattc agctgcttat cagtaatccg ttttagctga 2101201 agctggtata aatcgtcatc ggatattttt ttgtcttcaa cctgctgtct ttctttagag 2101261 ctaatgagct ttttcgcttc tttcggtcta gtcaaaatcc aataatcttt tttatcccgt 2101321 tctgttactt tttttgtatc gactttgatc atgtcagaca gcttttttgc gatctttaag 2101381 cgctgttctt gcgtggtcga tttagatctc gtgtatgtga ttgcatttaa agccttattt 2101441 gtcacaatgg cattaaagtt tcgatcataa attttcccgc gtggtaccgc tgagctgact 2101501 tcactttgtt cctgcttatt cgcttggttt ttgtaatcat caccttgcac gatctgcttg 2101561 atgcccagtt ccacaataat ccaggtaaat ataacaaagg cagctaaaaa taaaatattc 2101621 agccggatcg gaagcgactt ctttttctct ttatgatttt gcttttttgg tttatttctc 2101681 ctcataacat caccttttct atttacagaa agaaaagaca ctcaagtaag agtgccagtt 2101741 ttcattttaa aggttttttc gacttttttc tacagataac ccctttttgg caaaaaaatt 2101801 atctctcgcc ttttaaaagg gtcggttctg ttacccgttt ttggccgtct tcttccatgg 2101861 tttcattttc cccttctttc tccttaaaac gaatatcctt gacaaagtaa taaatcaaag 2101921 gatgtcctat acccaatatc gcaagtgaca aaggaattcc cacatcctct ttcagaaggg 2101981 ccacaatcag gagaaagcac aaaatggaaa caattctgcc ggcgttcaag aacatttctc 2102041 taagcacgat atattcaatt cttgcttttc tggcatgcct cgcgcgccct atcacatcat 2102101 atgtaagtga tacatatggc acaagcaaca gaggatagcc gatggcaata aaaacgccgt 2102161 acgttaataa tgtcgaaaag ctcatatgga acagaatcaa aaacagcgcg ccatacaaaa 2102221 taagtccgcc cagcaaaatc gatttttttc tcgccttttt cttaatcagc ctggatgcaa 2102281 agtagtaggc aaagaaggaa acagctgaat tgacaagacc gaatgtaccg agagcaagct 2102341 cgctgtttgt ctcaataaat acaaacacac tgattaaaaa gacaaaaatc ccttctctca 2102401 aaccctgaaa aaaatgcgca ttcgtgattc tccgccaatt catattgcta tggcgctctc 2102461 caaatacttt gctcagcata aaacggccct ttgattctct ccgttttaag aaaaagctca 2102521 tcacgacagc cagggcaaat aaactgaggg agagactgaa aatcactgta taacccgtat 2102581 tattttcaag ccttgagatc acgaatccgg ctacaatcgg gccgatcatt cctgcagagg 2102641 aagacagaat gcccataaac ccgttgaaaa agtctcgtgt atccggctct gttatttcaa 2102701 aggtcagcac gttaaacgct agccaataaa agccatagcc aactccgagc accgcgccga 2102761 ttagcacgag gcggctggcc gccgtttctc cggctaaaag cacacttaaa taaaaggcag 2102821 ctaaaaaaat gacgccgaac cttaaaatga ataccctgtc tatttttttg gctaaccgtc 2102881 cagccaaata aaaggttatc ggctgcattg tcacaatgga taaattatat atcgccaaat 2102941 caataaattt ccctgactgc ttccaaagat acacattaac aaatgtattg gacagtgcaa 2103001 ttcccagcga gtaaagcccg ccaatggtca gcagaaagag taagcctttg tttacgtcta 2103061 catcgcctat cacttttttt agtttgctca ttactgactc ccctttacta tcccttagtc 2103121 tgtctcactc aaaccgagat atgtaaaaag aagacataaa aaaacaaggt cccataatga 2103181 ggaccttgtt tgtgccatta ttttgcttcg ctgtatagac gagccacttc gtcccagttt 2103241 acaacattcc agaaagctga aatgtaatca ggacggcggt tttgatagtt aaggtagtaa 2103301 gcatgctccc aaacgtcaag acctaagata ggcgttttgc cttctgaaag cggagaatct 2103361 tggtttggcg tgcttgtgat ttcaagttta ccgttgttca caacaagcca tgcccagcca 2103421 gaaccgaagc gtccagctgc tgctgctgcg aattgctctt tgaatttgtc aaagcttcca 2103481 aatacactgt taatctcttc agcaagcgcg ccagtcggtt cgcctccgcc gtttggagat 2103541 aaaagtgtcc agaataattt gtggttcgcg tgtccgccgc cgttgttgcg gactgcagtg 2103601 cggatgtttt caggaacaga atcaagatct gcaacaagct cttcaactga tttgttggca 2103661 agagcagtgt ttccttcaac cgctttgttt aaatttgtca cgtatgtgtt gtggtgtttc 2103721 gtatggtgaa tagtcatagt ttccttgtcg atatgcggtt ctaaagcatc gtacgcataa 2103781 ggtaattctg gaagttcgta agccatgata attcctcctt agtatatatg tactgaaatg 2103841 ccgcttcaca gcgagccttt cttcattcaa tgtaacaaaa gaatgctttg taatcaatga 2103901 aaaagctcac gatttggctc atttcagcgg acatatttca ctttaaccga taatctgccc 2103961 cattaaacct gccgccagca tttcttatag gaccgtccat aaaaagtaac cgatcatcaa 2104021 aagctgtatg atgccctttg caataacccc tgttaaaaaa ccaatgagtg agccgaggcc 2104081 aattttaaac gctgacttta agtccttctg atggacgata agttctgcgc aaacagcccc 2104141 gataaacggc cccaatatga tccctgcaac cggaatgaca aaaggcccga ttaataaacc 2104201 gatcgtgctt ccccatatgg cagctttgct tcctccgaac ctttttactc caagcagatt 2104261 cgacacgtaa tctgctgcga ataatactgc ggcaaaaact gcctcaacaa gccagaacat 2104321 ataagaatac ggactgaatg aaaataaaaa tccgtacaat acaaatccgg caacaataaa 2104381 tactacgcta ggaataacag gatacaccag cccgataaag gcaatgataa aaaccgctgc 2104441 aatcaacagc caatacaaca tatccatagc ttccatcctc ccattttact ctgtcttctt 2104501 catgtcttcc ttgtattcac acgcatgcaa cgatacaata agcaacatat attagtttag 2104561 ctaggaagtg aagatagtga atgtgtttca gcttttcatt aaaagtacat actctccccg 2104621 tgatattgca aaaacaagat ttcaaggaat cggaaaagcg attctttatg tatttttgct 2104681 ctctgtcctg tttgcaatcc ctaccgctta ttatgtaagt acagggaccg taaaatcaat 2104741 gaacggcttt aaaactgttt taaacaaaga tttccctgat ttcacaattt caaacggcaa 2104801 acttcaaacg gatgagaaaa aagccacgga atctcaggca aatggtttcg ttatcgtgtt 2104861 cgatccgaca gactcctatg gcactgaaca aattgaagca aagcaaaacg caatcggcat 2104921 ccttcagaac aaatttgttt tggccattga cggacaagcc caagaaatgt cttactcaat 2104981 gatgccgtca gagttacaga aaaaagatgt cattgcaggt ttaaaccaaa ataaagcgat 2105041 gattgtaact gttctctcag ctcttatttt tctcgtaaca gcagcgggaa aatttattga 2105101 agtatcgttt ttagcgctta tcgggttaat cattaagaat tcgcagaaaa aacatttatc 2105161 ctatcatcag ctctggaagc tttctgctta ttccatcaca ctttcaactg tattctttac 2105221 aatcatgcgg gcactagaag caaccgtacc aagtgaattt ttgctgaact ggtttgtcaa 2105281 ttttgtcatc ctgtttctcg ttttaaaaga gattccgtcc aaaaaagtaa ttaataaaag 2105341 ttaaattata tttattttta tcctttaagt agagagtgtg aaagcatttg cattaacttt 2105401 ttacttaagg gatatttaat aaaatgtata gagcttaaac agatacattt ataaaaaaag 2105461 ctctacaatt actcaagaac aagctctgga caataatatc agaagtagta agatgtaaca 2105521 tgaaagaagt tcttaacagc atttgacata tgtttttaac aaaataagaa taatgttaaa 2105581 ttttaactaa tagactagtt aaaatcatat ggcaaaatat tttgcatcct ttcacaacat 2105641 atttacataa gatagttgct atttaaaaag ccaggtacca atagggcacc tagctttcag 2105701 aattaaatca tcaacaagtt agaattatct tctttccttc tattctcatt attgaactgt 2105761 tatctttttt gtgggtttat gtatacaaat gcagctccct tagctttccc cttatatact 2105821 gataaaccta ctgcccaagg tgttcctgtc ggttttggta atttactgaa gtaaaacttt 2105881 ttggttggag ttctacttga aaagtaccct gaatattgcg ggccaatgtc cccaccctca 2105941 actatagata caccaaagct cttataattt agtttaccgc attttccatt tgtttcggcg 2106001 taagcatcaa tagatgttgc actcttagta tatgtataag catctgtaat aactcttatt 2106061 ttacaaccag aaataccact taccggttgc caaccactgc ttgcagcctc tgctttttct 2106121 ttaggtgcaa ctaccaaagt taacattagt agcaaaatta aaaacacaga aaattttcct 2106181 tgcttcattt tgtagatcct cctttaaact attacataat tatcctaaca gatccattgt 2106241 tcattgtaaa taatggaata cgagttttat attataaaag cctctttttg atctaatttt 2106301 gcactatttt ctattttcta tctgaagtta atgtttagtc gaagaaatcc tgtcaaaaaa 2106361 gcgcctgtat aaaaaccgag cattcgcagt ctcttttctt ttgtcatgaa tcgaaatgga 2106421 caagcatact atggtataaa atttcgtatg cgggaggaaa agcgatgaag cgtctcacct 2106481 tagtatgcag cattgttttt atacttttta ttctttttta tgaccttaaa attggaacca 2106541 tacccattca ggacctccct gtctatgaag catcagcaaa aacggctgta caagaaccgg 2106601 cttataaaac ggtgaaggta aagccgggtg atacggttat gtcgatagtc ggatcagcag 2106661 gttctccgga tgacattgta aaggattttg aagcactgaa tccaaatgtg aaagctaacg 2106721 ccattcaagc cggaacagcg tataaattcc cggtctaccc ttaatttaac gttaatttct 2106781 tgtcagttcg gcgaagacac tgttacaatg taatttgtaa aataaattca cataaaccat 2106841 actagaattg ttatatctag aagcggcaac tacaattaag gagcgattgc aagtgagtga 2106901 aatcacacat cgtacaaaaa cgcgtcccgt caaagtggga cctttaacaa taggcggcaa 2106961 caatgaagtt gtcatccaaa gcatgacaac aacaaaaaca catgatgtag aagcaacggt 2107021 tgcggaaatt aaccgtttgg ctgaagccgg atgccaaatc gttcgggtag catgtccgga 2107081 tgaacgggcg gcaaacgcca ttgcggatat taaaaagcgc atttccattc ctctcgttgt 2107141 tgacatacat ttcgattata aacttgcgtt gaaagccatt gaaggcggcg cagataaaat 2107201 ccgaatcaac cccggcaata tcggccggcg cgaaaaagtt gaagcggttg ttaaagcggc 2107261 caaagacaaa ggcattccga tcagaatcgg agtaaacgcc ggttcattgg aaaaacggat 2107321 tttagaaaaa tacggttatc cgactgccga tggaatggta gaaagcgcac ttcatcacat 2107381 taaaattctt gaggatcttg attttcacga tattattgtc agcatgaagg cctctgacgt 2107441 gaaccttgca atcgaggctt atgaaaaagc agcgaaagcg tttgactacc cgcttcacct 2107501 cgggatcacc gagtcaggaa cactgtttgc cggcacagta aagagcgcag caggactcgg 2107561 cgccatttta agcaaaggca tcgggaacac catgcgcatt tcactaagcg cagaccctgt 2107621 agaagaggta aaagtagcaa gggagcttct gaaatctttc ggcttagcct ccaatgctgc 2107681 cacgctcatc tcatgcccga cttgcggccg tattgagatt gatctaatca gcattgccaa 2107741 tgaagtggaa gagtatattt ctaagataaa agcgccgatt aaagttgctg ttctcggctg 2107801 cgctgtaaac ggacctggtg aagcgagaga agctgatatc ggaatcgccg gcgcacgcgg 2107861 tgaagggctg ctgttccgga aagggaaaat tgtccgtaag gttccagagg aaacgatggt 2107921 agaagaactc aaaaaagaaa ttgacattct tgctgaggaa cactacgcaa aacttgaagc 2107981 tgaaaaagca aaattaaaag aagaaacaca aaaagcttga cgggaacccg tcaagctttt 2108041 ttgtgttaga aaaatggaat aataaatatt ccaagcacta atgaaacgac accgataccc 2108101 attgcccagg ctccaaggcc ttgagcacct cttcttcttg cgatatagcc gacaataata 2108161 ccagcagctc ccaataaaac aggcagtaca aacaatgaaa tgatggacaa ggctaaagcg 2108221 atgtacccta ttccccgtcc ttcattgaca ttgccgccgc tgcgatcatt gtcttggtca 2108281 ttgctgcggt cagcagcacg ataaggctct gcgatttcag cagctgtttc ctcaaaaaaa 2108341 ccgtcattgt cgcgggtaat atttgtccct tcagatccat gatcaacata gtaactgttg 2108401 ttatcacgct tttcgtaatc gtttgccacc ttcaattccc ccttctgttt tattaaagga 2108461 gcttttatag tttgatccat tttgcctgat tcatgtttgc taaacttttc tgttaatgtc 2108521 aattgtttat gttacacttg aagggatgaa actgaaggag tgtgggcatg ttacgcttag 2108581 gaatagatat tgacggcaca atcacggctc aggatacatt cgtcccttat ttgaaccgtt 2108641 cgtttaatct ttccatttca ttaaacgata tgacggatta tgatttaaca aagctgttaa 2108701 acattaccca ggaagaattt tgggattgga tgaatcaaaa tgaagcgatc atatataagg 2108761 aagcattgct tgcacagcat gcgaaacagt ctctcgatct tctcaaagag gagcacaagc 2108821 ttatttatat tacagcgaga cggactcatt taactgatat tacttatgaa tggtttgaca 2108881 gacaaaacat tcattatgac cacatcgaac ttgttggggg tcatcacaaa gttgaagcgg 2108941 tcaagaatca taacatcgac ctgttttttg aggatcatca cgggaacgcc atgatgattg 2109001 cgaaagaagc cgggataccg gtgattttgt tcaattcccc ttataatcag cttccgattg 2109061 attcaaacat catcagagta aacaactggc tagaagccgt tcaatggatg aacaacaaca 2109121 agcatcactt aatacgcgtc aataactgaa aaaggagccc aaaccgggcc cctttttcat 2109181 atatacgcat tttacgcagt agtgttttct tggttttccg ctgtacaatc agggcatgtg 2109241 ccataaatct caaatttatg cccgctgacc tgatagccat ccaaatcatc acaaagcttg 2109301 tccatcggac atgattcaat ttcctttgtt ttgccgcagg caagacaaat aaaatgatgg 2109361 tggtgatggg tgaatgaaca cttaaatcgg aagagctttt caccggacag ctcagttgtt 2109421 tccaaaatcc caagttcttc atataaagaa agatttctgt agattgtatc aaagcttaag 2109481 cctggataat catcattcag tgcagacagt acgtttttag cggtaagata tctgtctgaa 2109541 tcagcaaaaa gctgcagcat atcctcccgt ttgtttgtat atttatatcc gttttctttt 2109601 aataggttca gcgcttcttg gacgttcatg aagggtcccc cttttcgctt tgcttaagaa 2109661 cgtatcacat gtatgaaaaa gaaaatggca gctgtctgtc cagcaagcca ttttctttac 2109721 tgcagataaa attataccca taaaatgaat aaaagtaaat gaaagcctag tggattgcgt 2109781 ttttgaattt tccgcctctc gtttcatgag tattcataat tgttatgaat gcattttgat 2109841 caacttcaaa cacgatcgat ttgagctttg tcacttccag ccttgtgaca accgcgtaaa 2109901 ttacgtcttt ttcttcgtcc gtatacccgc ctttcccctt cagcttcgtt gtgccccgac 2109961 cgagacggtg caaaatcgcg tcggaaatct catcatactg ctcagacaca ataatgacag 2110021 cttttgtttc atcaagccct tggatcacgg catcaatcgt tttcatcgca atataataag 2110081 tcatgaatga gtacatcgct tgctcaggac cgaacacaaa aactgcccaa atgaaaatga 2110141 acacattgat gaacataacg aactcaccta cagaaaacgg gagttttttg gtcagcaaaa 2110201 taccgagaat ttctgtacca tccattgaac ctccatttcg aataacaagc ccgacgccaa 2110261 agccgagtaa aagacctccg aacacagtag ccaaaatagg ctgggttgta atggcttcta 2110321 catggtgaag tgaggattca ataacggcaa gcccgacaat ccctataaac gtagagacta 2110381 gaaaggtctt accgatatat ttatatccga agatcataaa aggaatattt aatatgacaa 2110441 cgaaaaaagc gaaattcaga aaggggtttg acataaagag gtggtctaaa ataagagata 2110501 caccgataat cccgccatca ataaaatcat tggggattaa aaataattca atacttacag 2110561 ccgcagatgc agctcctacc agaatcataa agaccctgaa aataaaatgg gtaaatgttt 2110621 ctttcttatg ttgttttgtt ggggtcataa aatctccttt cctgcaataa ctattttaaa 2110681 tacattataa atctatttta ccattaaaca ctgacacatt ttactgattt gcccatacat 2110741 taagtctgga ggtggaatga ccgatgattt tatttcaaag aattattttg cagcggctta 2110801 atcaggctac tgctgatgat ttgctgaagt actcaaaaca atacggaatc agcttaacaa 2110861 gatcgcaggc cgttgaagta gcgaacctgt tatacgggaa aaatgtaaac atctttaatg 2110921 agagtgaacg aatgcggctg ctgaaacaag tagagacgat tacatcgaaa gaaacagctc 2110981 aaacagttaa tgaactattc aaacaattta caagctaaaa aatgggggtg ttatccccca 2111041 ttttttattg ctgtaaaatc ttttcaagca atgtatcatc aaattgtttt tctttcagca 2111101 tttcaatctc aaaacggtat ggcggttttt tgttcttttt atcttcaccg acgtatggtg 2111161 tttcaagaat ttttggaatg tcttttaact gctcatggtg aacaacatat tgcagtgcgt 2111221 caaaacctat ttcaccaaag ccaatatttt catggcggtc ttttctcgca cctttgacat 2111281 ttttgctgtc attgatatga agcactttaa tacggtcaat gccaatgatt ttatcgaact 2111341 catttagcac tccgtcaaag tcttcgacaa tgttataccc ggcatcatgt gtatggcacg 2111401 tgtcaaagca cactgacagc tgctcattgt gtgtaacgcc ttcgataatc tgcgcaagct 2111461 cctcaaagct tctgccgcat tctgatcctt ttccagccat tgtttctaat gcaatctgga 2111521 cattttgatt cggatcaatc acttcattta agccttcaat aatttttttg atgccggctt 2111581 cagctcctgc ccctacgtga gcgccaggat gaaggacaat ttgcttcgct ccgatggccg 2111641 ctgtccgttc aatttctgaa cgaagaaaat caacacccag ctcaaaagtg gacggatttg 2111701 tcgtgttgcc aatattaata atataaggcg cgtgtacgat aatctcgtca atgccgtttt 2111761 cttgcatatg tgcccggcct gcttctatat ttaagtcttc aattttcttt cggcgcgtat 2111821 tttgcggtgc gcctgtatag atcataaacg tattcgcccc ataagagact gcttcctggc 2111881 ttgcagccag aagcatatgt tttccgctca tagagacgtg tgagcctatt ctcagcaaca 2111941 ggttccccta ctttcttttc ttagattggt ttcttctctg ttttttcttg attttctcca 2112001 tctcatagct cattttcttt ttatacccag gcttaacctt cttcggcttt ttcacgagac 2112061 gatgagcaat ttcatccgct tcattcggcg tttttttacg ttttttgcgg cgctgacggt 2112121 catcgccttt tttccattcg cccttttcaa gctctaagta ctcaaattcg atgcccattt 2112181 tttcaagtct tactaatgca tcctcatcag taagctcata aatggtcatc gcttgtcctg 2112241 atgagccggc acgagccgtt ctgcccacac ggtgaacata gaaatcgaga tcatccggca 2112301 gctcatagtt gataacatgg ctgacacctt taatatcaat acctcttgcg gcaaggtcag 2112361 ttgcaatgat atatgtgaat tccaaatcat tgatctgctt catgactttt ttccgctcac 2112421 gtggtgttaa tccgccgtgc agcaagccga ttttcatgcc tttgccagtc agatactggg 2112481 caatatggtc agccgtattt ttcgtgttgg caaacacaat ccccaggtat ggattcagat 2112541 gcgacatgat gtcaaaaagg agcttgtcct tgtcacgatg tttcgaagga atgaggatat 2112601 gctcgatttt cgcagcagtc acctgttttg gctccacatg ggcgtatttc ggattttcca 2112661 tgtatttctt caagaatggt ttcagctttt ccggtatggt cgctgagaac acaagcattt 2112721 gcagatcctc aggcatgcgg gaaccgatgt aatctacatc tgcaaggaat cccatgtcca 2112781 gcattaaatc cgcttcatca ataacaagag attccgcttt atgaacactt aacgcctgtt 2112841 ctttgattaa gtcagcaatc cgtccaggtg taccgacaac aagatgcggc tgtattttca 2112901 atttatcaat tgatttttgt ttatcagtgc ctccgataaa acatttcgag cgaatctgac 2112961 ttccttcttc accctgcgtg attttaagcg cttcctgata aatctggttg gcaagctctc 2113021 ttgtcggagc cgtaatgact acctgaacga catccttagc aggatcgatt ttgtttaata 2113081 aaggcagtaa ataagcgtga gtctttccag tacccgtctg agactggccg atgacgcttt 2113141 ctttttttaa cactgcagga atcagccttt tctggatatc agtcggttcg taaaaaccaa 2113201 ggcgatgtac tgcatctata ataaatggtt tcaattcata aagttcaaat ttcgtttctt 2113261 tcatttttcc cagctcctta aagcggcaca ttatgtgtcc atcatcacat tatacccgat 2113321 tttgcttaaa aacaccacgt ttgcaaggcg tttgttttat tcagttatgt aaagcaaata 2113381 ccgcagccca tgcatattct aatagcagag agagctgaaa ggaggtacaa gtatgttttc 2113441 accgcagcag ccaatgagaa attacccaca gcccggaccg ccccgcccca tgccaaatca 2113501 gcgaatgatg ggcagaagac cgcctaatat gcgaggacct tcatttggag cacagcagca 2113561 aggttttcag caagccggac aatttcttcc tcaggcaaat gccggagcga gaaatggtgc 2113621 aggtgcaggc ggaggcttaa aaggaatgct gtcaaggttc ctccccggcg gaggaggcgc 2113681 tggcagcgcc ggggttcccg gaattccagg agcaggtgca gcagcgagcg gaggtgctgg 2113741 cctgcaaggc attcaaaata ttgccaatcc tgcatcatta tccagtatgc ttggaaatgt 2113801 gcaaaaagta ctcggcatgg cgcagcaagt cacccctatg atccagcagt acggcccatt 2113861 agtccgcaat ctgccagcaa tgatgaagct gtacagccaa ttaagtaaaa gtgatgatac 2113921 tgagacagag gccaatgagg aaagtgaaaa acaatccgtt tcagaagaat catcagaaaa 2113981 agaaaaagag actgaaacaa aaacctcaga tgggaacaaa aaatcaaaac caaaaagttc 2114041 ttctctccca aagaaatcta aaacaactga caataaagaa caagaattaa aaacatctgc 2114101 cccgaagaaa aaggaagctg cctctcctgc tccgaaaaga acatcaggca gttcaaaacc 2114161 gagattatat atttaacatt ctttgatatc ttaagtgaga ttggctataa tgagatcaga 2114221 agaatgcaag aatagagccg tttgattacg gctttttata ttgcctttac tcacttcagt 2114281 attggaggac aaccgaaaat ggacgtaatt aaaatttcac cgcgcggcta ttgctatggt 2114341 gttgttgatg ctatggtcat tgccaaaaat gcgtcgctag ataaaagctt gccaagaccc 2114401 atctatatac tcgggatgat tgttcataat aaacacgtca ctgatgcgtt tgaagaggaa 2114461 gggattttta cattggacgg ctctaaccgt ctggacatct taaagcaggt tgacaaagga 2114521 actgtcattt tcactgcgca cggtgtttct cccgaagtca gaagaatcgc agaagaaaaa 2114581 gggttagtcg caattgatgc tacatgtccg gatgtgacaa aaactcataa tctaatctta 2114641 gagatgaaag aaaaaggata tcacgtgatc tatatcggca aaaaagggca tccagagcct 2114701 gagggagccg ttggcgtagc gccggagatc gttcacttag ttgaaacaga agaagatgta 2114761 aagaaccttg atatccaatc tgagaagtta atcgtgacga atcaaacaac aatgtctcaa 2114821 tgggatgttc acgacattat ggagcttgtc aaagaaaaat atcctcatgt cgaatatcac 2114881 caagagattt gcctcgctac tcaagtgcgg caggaagctg tatcagagca ggcaaaaaaa 2114941 gcggacttaa caatcgttgt cggagacccg aaaagcaaca attcaaatag gcttgctcaa 2115001 gtgtcagagg aaatagccgg gacaaaagca taccggatcg gcgacttaag cgaattgaag 2115061 ctcgaatggc tgaaaggcgt taataccgtt gcagttacag cgggagcttc aacaccgacg 2115121 ccgatcacaa aagaagtcat tcgcttttta gagcagtttg atcacgaaga tccatcaact 2115181 tggacaactg aacataatat accgctcaaa aaaatacttc caaaagtaaa agcaaaaaac 2115241 tgaggctgta aaagcctcag tttttttata gaaatgtaaa tggatttgta tctgtttcag 2115301 aaacaaagat attcacgcca aactttttat cattacacat tgatgtaagt tttctcgtga 2115361 cgccttcttt catgattttt tccgcgtaat ggcccggatc aaccacattt aggccaagca 2115421 tcatcgcatc atgggccaca tggaagtata aatctcctgt gacgtaaaca tcggctccct 2115481 ttcgttttgc atgatgaata tacttgtttc catctccgcc aagaacagct acttttttca 2115541 ccatgctgtc agcatcccca accattctga caccattgac gtcaagcttg tctttcacaa 2115601 ataaagcgaa ttccttgagc gtcatctcat ttttaagggt tccgacacgg ccgagccctt 2115661 tttcggcggg agtctgttcg acaggataga tatcgtaagc gacttcttca tatggatggc 2115721 tttttatcat tgcattgata acagcctttt cgacgctttt aggaaataca gtctcaagcc 2115781 ttacttcatg aacaagctca agctctccca cttcaccgat aaaaggctta gctccgtcca 2115841 atggcttaaa gctgccgatt ccttcagatg aaaacgcgca atggctgtat tcaccgatat 2115901 ggccggcccc cgcatttccg agcgcggctc tgacctgctc ttcatattcc ttcggcacgt 2115961 aaactgccag ctttttcaga ggatccgtat aagtaggtgc cagcacttcc gtctcactca 2116021 gctctaatgc ttcagcaagc aaatcattca caccgccgtc cgcaacgtct aaatttgtat 2116081 gagctgcata aacagcaata tcatgcttca aacacttttc aattaacctt ccggcaggct 2116141 gatctgttga aatatgcttt agcgaccgga aaattggtgg atggtgtgca ataatcaagt 2116201 caacctcttt ttcaatcgct tcatcgataa cgctctctaa cacatcaagt gtaaccatca 2116261 catttttaat tggtttgttt aaggtgccga tttgcaggcc gattttatct ccttcaaccg 2116321 cataggcttt cggggaaaat tgttcaaaca gctggatgat ctgctgccca tttacacttt 2116381 tagccatgat cgattacctc ctttaacagc tccattcgat cggcgagctc ctttaatttt 2116441 tgtttgtttt gctctgtatc cgccgcttgg ctgatctgtt cataaatgct ttgagtgtgc 2116501 tgaagctctt gtgtccactt tttcaaaaag acagcatttt tttcttttgc caagaaaggg 2116561 ccaacgagca tcccggctga taaagaaata ccgtcataag ccgcatccct gtctcccgct 2116621 tctgccacca gcacctcata gcactttccg tcctcttcaa ggattacctc atctatcagc 2116681 gcatatcttt ctttataaag ccactccctg atatgaacag catgaatatt cggctgtaaa 2116741 atgagccgtt ccttccccgt taatttgtct ttgcccgctt ctaaaatgtg agcgatcaaa 2116801 gccccgccca ttccggcaat cgtaatggca tcagcttcac cttttttaat cacttccagt 2116861 ccgtctccct gccttacaga aatgtgcgag tttaagcctg atttttcaac ctgccgcttt 2116921 gcagacaaaa atgggccgtc tgttatttct ccggcaatcg ccccgctggc tttatgattc 2116981 agcaccgcat aacaaggaag gtaggcgtgg tcagagccga tatcggccat caccgctcca 2117041 ttcggtatgt actccgctac tgtttgcaat cgtttagata attttaattc gttcacttgt 2117101 catcacaact tttctcaatc attttttcct ttactatcat ataaaaaatc agcccggaat 2117161 ccaagctgaa gcaaatgatt ttgaaattat ttcttttgat gcgggtctgc acgcagcagt 2117221 caaaaataaa aggctgtcga gaacatctcg gcggcctgtg aatgtataaa gagaaaaata 2117281 gttcttttat ttaatttttg acacccactc tgccatatca tccagcttat cggccggaac 2117341 aagaccggaa ggcattccat taccgccttt ttcgatcttt gttttaattt cagcgacatc 2117401 tttcttatcc cctacacctt ttaagctagg acccgaaaca ccttcataat tttcaccgtg 2117461 gcatgcgatg cagtttgcct tgtaaatttc ttctggtgaa gcgtttgcat ctttcttttc 2117521 agcagatttg ctttctcctc cgctcgcaat ctcccgagag tcatcaagtc cttttactga 2117581 taaaaagaaa gttagaccaa ttcctaaaac agcgatcagc aaaaatggaa taagcgggtt 2117641 ccatttcatt tcccttcccc ctttttgatc cttcccccta tgtaaacact tctaattcta 2117701 acttattttt acaaaaagta aatggattgc tatacaaaag ttttttattc acactttata 2117761 caaaattgaa tagaaacatg cctaaatctc taatatcctt tttattctat tgtataatgt 2117821 attgtatacg cttacaatag aaaatatgga attagatttt gaaatttttc accacaatgt 2117881 tcatttgcaa atgacatcat ttttcagtaa aataaaggca tattatccat atatcttttt 2117941 aaaaaaagaa gaacggatct tcaagacccg ttccatctta ttcaaggaaa tctttcaaac 2118001 gtttacttct gctaggatgt cttagtttcc gcaacgcttt ggcttcgatt tgtcgaatac 2118061 gctctctcgt tactccaaat actttgccga cctcttctaa tgttcttgta cggccgtcat 2118121 caagaccgaa tcgaagacgc aatacatttt cttcacgatc agttaacgta tcaagcacat 2118181 cttccagctg ctctttcaat agctcgtatg cggcgtggtc agaaggtgaa gttgcttctt 2118241 ggtcttcaat gaaatcacca aggtgcgagt catcctcttc accgatcggt gtttccagag 2118301 ataccggctc ttgagcaatc tttaagattt cgcgtacttt ttcaggcgtt aaatccatat 2118361 cttccgcaat ttcttcaggt gttggttctc tgcctaagtc ttgcagtaat tgacgctgca 2118421 cacggattaa tttattaatg gtttcaacca tatgaacggg aatccggatc gttctcgcct 2118481 gatcggcaat ggcgcgtgta atcgcctgtc tgatccacca cgtagcatac gtactgaatt 2118541 tataaccttt gcgataatca aatttttcaa cggctttcat caggcccatg tttccttcct 2118601 ggatcagatc aaggaacagc ataccgcgtc cgacataccg ttttgcgata ctgacaacaa 2118661 gccgcaggtt cgcttcagcc aatctgcgtt tagattcttc gtcaccttct tcaatctttt 2118721 gagcgtaggc gatttcttct tttgcagaaa gaaggttaac ccgaccgatt tcctttaaat 2118781 acatacgaac tgggtcattg attttaacgc caggcggtac acttaggtca ttaaggtcaa 2118841 attcttcttc ggctttggca agctgctgaa tattaggatc ttctgtttct tcattctcac 2118901 taattaattc aacaccttgt tcacctaaaa attcataata ctcatccatt tggtctgatt 2118961 caatttcaaa gctggacata cgctcagcaa tttcttcata tgtcaaaacg ccacgttttt 2119021 taccagactc tgttaattgc tcttttactt ggtcgaatgt taattctgtc tcgtgggttt 2119081 gtttatcagc cattatggat ccctccttcc aaagcttgca acgaattcta taagcggtat 2119141 gattcttatt cggtccattc aggcgttttc tatgtgaact gcctttaaca atgtgcgaat 2119201 aatgaaatga caattcatga tgaggttaag cgatctattt gctcctccgc aaggaatcat 2119261 tgccaataaa tgctcctcat cagttctcca gttattttaa agatcggttc aatgtaacga 2119321 tttcttgagc caaagaagca gctcttaaaa aatctttttg cctttctgct tcggctcttt 2119381 ccgcctcttt ttcttttatc attgaccaat ttctttgatt caacactttt tttacataat 2119441 ctgataactc ggcttcgcta agctcttgat taacctgaag cattaatata tcggacaaga 2119501 gctggcttat atgatcatcc gtcaccctgg ccatcagatg ctgaggcgtc agctcggctc 2119561 cctcttcata aaaagcataa agataagcgg ctaatgcccg gtgctcatca atattaaatt 2119621 gaaaccctac ccggtcaatc acttttttga tgacgctccg atctcgaagc atgtgagcga 2119681 gtaacagcct ttctgcattt tcatacgccg gacgcaaacg tttttgcctt gcttttgtcg 2119741 tcagatgcgc tcgccgcgtt ttagtttcac cgctattgtc agcaggtttg ttttgcttgc 2119801 tgaaaacaga cagctgctca gttaaagact cctgtgaaag cgaaaactct gaagcaagct 2119861 gctttacata gacttcctgc tctagagacc ctgaaagcgt gctgatttct ttcagtacgt 2119921 ctttaatgta agctaggcgg tcgccttcat cggacaggtt ctttcctttt cggaaatatt 2119981 gcattttgaa cgccattacg gtgacacttg cgtcaataat gtcgttttta aatttttccc 2120041 cgccgaattt tttgatgtaa tcatcagggt ccaatccgtc aggaatcatt gcaactctga 2120101 ctttgcagcc ttttttttgc agaagctccg aagcttttaa ggtggcttca taaccggctt 2120161 tatcagagtc atagcaaaga atgatttctt cgacgtttct tctcaggatc ttgacatgat 2120221 catctgtaag agacgttccc atcgtggcta tgctttcctt tacatccgag cttacggccg 2120281 atatgacatc agcaaaccct tcaaataaga ctgctctttc ctgctttctg atatgaaggc 2120341 gggccttata aaaattgtaa agcagtttgc ttttatgaaa gagcggggtt tcaggactgt 2120401 tcatatactt aggctgctgg ctgccaagag ccctgcctga gaaagcaaca acagccccgt 2120461 gatgatcatg gatcggaaac atgacacggt ttctgaagcg gtcgaaatat ccgcttccgt 2120521 cttcgcgtct gatcaggaga cccgcttttt ccatttgcgc ctcactaaat cccctcttta 2120581 caaggaattt cgtgataaag tcccaagaat caagagcata gccaatctga aattcattaa 2120641 tcagctcttt cgtaaagccc ctagaaagca gataatccag tgcctcttga ccttcttttg 2120701 tatttattaa caaatgatgg taaaatttct tcaggagctc atgtgcctca gccatttttt 2120761 gttctccaga agactctggc cgggctccgg aatggactgt tatatcatct ggaaaatcaa 2120821 tttggtattt gtcagcaagg tgagaaaccg actcggcaaa agaatagcct tccatctgcc 2120881 ttaaaaaaga gaaaacattg ccgcccgctc cgcagccaaa gcaatgaaaa atctgtttgt 2120941 cgggcgatac ggaaaacgaa ggtgtgcttt ctccatgaaa aggacagagt ccaaagtagt 2121001 ttcggccttg cttctttaat tgaacataat cacctatgac ttcaacgata tctgccgact 2121061 tttgcacctg atccacaatt tcatctggta tccgatttcc catcttataa cactccgtcg 2121121 tacattattc gatgctttag tgcaaaatcc cttcatcgtt cgacaggatt ttttgcagca 2121181 gtgtaataaa tcgttctcga tcttctttat tcaatttttt aggccctttg gcatatacgc 2121241 cttttcttct ttgtttgccg gaaaaatgac ggccctctag ggcaaaatca atcgtgtctt 2121301 ccttgtaaag acgacctctt tccgacataa cagagacatt tctgttcaac agcagagatg 2121361 ctaatccgat gtcctgcgtc acaacaatat ctcccggttt cacgtgattt gcgatatata 2121421 aatcagcagc ttctttatga ggatcaacat acttccattt ttcttcattg cttctggaaa 2121481 gctgataatg ttcaaatgaa gcgacaaaaa gaacttgaac ttcatactcg gatgctgttt 2121541 gtaaaatttc atcttttacc ggacaagcat cagcatcgac aaaaatcgtc ttttcttgtt 2121601 cattaagaag agtaattctc catccctcca ttaaactcct gcataaaagc aagcaaaatc 2121661 gcacatcctt tattattgtg gatgtatatg aatttgtcga aaaatttccg ggagaaattc 2121721 ttgacatctt acccataata gtttattcgt atcacacgat ccttaaacct aaaattaatc 2121781 attttatcac aattttttat tataatacaa acttcacaaa gatgctattg tttttcatta 2121841 ttcccttttg gcacagccaa aaacccagga tagagcgtcc tgagttatat gttttttgtt 2121901 ttgagatgat ggataatatt tgctgtttcc tcaaccgctt tatttgaaac atcaacaacc 2121961 tggcagccga tccgatccac aatcttttcg aaatactcga gttcctcttt gattctgttg 2122021 atatttgcat aaatcgcttt atcattaagc ccgagtgatt ttaaacgttc ttttctgata 2122081 tgattcagtt tatcagggct aatctttaaa ccgatgcatt ttttcggatc aacgttaaag 2122141 agttcttccg gcggatcaac ctccggtaca atcggaacat tggcaacctt caggcgtttg 2122201 tgtgcgagat attgagacag cggtgtttta gacgttcttg acacgccgat caaaacgata 2122261 tcagctttta aaatccctct tggatcacgt ccatcatcgt atttaactgc aaactcgatg 2122321 gcctccactt ttttgaaata atcttcatca agctggcgca cccgccccgg ttcgtatttc 2122381 gctgttaaac cgtaggctgt ttccatttta tcaatcaacg ggccgataat atcataatat 2122441 aaaacatttg ctttttccgc ttcggctatc aaatattctc tgatttccgg caccacgagt 2122501 gtaaaacaga taatgccgcc gtctgccttt gcaagtgaaa tcacttcatt gatagtgcct 2122561 atatcttcaa cataaggaat tcttcttaca tgagtatcat ccgccgatcc gttaaattgg 2122621 ctgagtgctg cttttactac caattcagcc gtttcaccga cggaatccga tacaacatag 2122681 atgatgcggt tattcatatt atccccccgt tagtttgcaa tcttatagga tttcattttc 2122741 agataaactg acaagtattt tggtcatatt tgtttttgtc actctgccga tcacttcaaa 2122801 gcctttatcg gtgtctttga tgacaggcag tgcatcaatt tgtttttcta ttaagtgctt 2122861 tgcaatgtcc atcacataat cctcgcgtct gcacaccgta atgttcggca tccttgtcat 2122921 gatgatgtga acagggaccg atgtaagctc ctgctggcca atgctcgctc tgagcaagtc 2122981 ttttcgtgaa agcaccccga ctaaaacagc atcgcggtcc accacaaaca gagtacctac 2123041 atcttctaaa aacatggtgc aaatcgcatc gtacacagaa acgttttcgt gaatcactac 2123101 ggggatagat tgaaagtctt tcacctgaag ctttttgagt ttatccgcca aaagctgtgt 2123161 gccggttttt cccgtataga aataaccgac tctcgggcgc gcctcgagga atcctgacat 2123221 ggtgagtatg gctaaatccg ggcgcaatgt cgccctggtt aggttcagct tttctgcaat 2123281 atgctcccct gtaatcggcc cgttttcttt tacaatctgc aaaatatgtt cttgccgttt 2123341 atttagttcg atcgtactca ccaccttttc acttcatagc tatgtaaaga aataacaatc 2123401 catattataa cgtaaatatc ttgtaatcaa acaaaaaact tataaatggg gaaaagacga 2123461 ttaccgatca cacagcaacc gccttttctc tctttatttt acaataaggg cattcatatt 2123521 cgcaaaggac ttgatctcat ccgccaagct taccatttgc gctaaacgat ttgcctttaa 2123581 tgactcatta tccgctataa ccattgtatg atcgaagtaa gcatcgatcg gttcttttaa 2123641 ggctgcaagt gaagcaagcg ccgcctcata atcttttttg ctgaagtttt cctgcagatt 2123701 ttgcttcgct gtttggtagg catcaaacag ttttgcttcg tattcatttt caaacagatc 2123761 aggctgaatg tctccgcgga ctcctttttt gctgatagag atcactcggc ctaacgcttc 2123821 ggctgtttcc ttaaagccag gtgcaccaag cttttgctcc agtacttgtg ctttatgcag 2123881 cgcagagtac ggctcaagct cagagctttc cagcacggcg tcaatgacat catgtctgat 2123941 ttgttcagca ttcaagacat atttcaagcg ctgagtgaag aaatccagca gttcattttc 2124001 tttatcggtt tgaacgaaag taagcagctc ttcaaatgaa attccccagt tgcggtcaag 2124061 aagaatcgca acaataccgc ttgcttggcg gcgcagtccg taagggtcct gggaaccggt 2124121 cggaattacg ccgatagaga agaatgaagc gattgtgtca agcttatccg ccattgctac 2124181 aacagctccg gtgaaagtag aaggcgtttc tccgcccgct gatctaggca tataatgttc 2124241 attaactgcc gcagccacag cttcatcttc gccaagcatt ctcgcatact tttcgcccat 2124301 aattccttga agttcaggga attcatatat catatgcgtc acaaggtcga atttagaaat 2124361 ttcagcagcc cgcttcacat gttttaatgt atcttcatca gcctgaagac gaacggcaag 2124421 tttctctgcg attgatgtga ctctcctaac cttatcagca agagaaccaa gctcttcatg 2124481 gaaaacgata ttttcaagct tcttcacatt tgcatcaatg tttagtttct gatcttcttt 2124541 gtagaagaat gaagcatcag ataaacgtgc gcgcagcact ttttcattgc ctcgggccac 2124601 attttcaatc gcgtggctgt tgccgtttcg gactgtgata aagtgaggca gcaggtcacc 2124661 gtttttgtct ttgacaggga agtagcgctg atgctctttc attgtcgtga caagcacttc 2124721 ttcaggaatt gacagaaact cggattcaaa tgaaccgtaa agagctgtcg ggtattctac 2124781 taaatgattc acttcatcaa gaaggtcttc gtcaactgga atgctccaat tgttttcagc 2124841 agccattgtt tccagctgag attgaatcat ttgctttcgg acgctaggat cagcaataac 2124901 atgctgtcct ttgagctgct cttcataagc tgaaggtgat tcaattgaca cttcatgtcc 2124961 gaggaaacgg tgtccctgtg ttgtccgtcc agactcaacg tttgtgatcg aaaatggaat 2125021 gacatcctgt ccaaataatg cgacaatcca tttgatcggt cggatataac gcaaatcttc 2125081 atttccccag cgcatgtttt tcgggaaatg caagcttgta attaaaccgc tcaattctgg 2125141 cagaagcgac ttcgtttctt ggccggcttg gaatttttgc acgaatacat actctatgcc 2125201 ttttacttct ttgatgtaca ggtcttccac atttgcgcct tggccttttg aaaagccgat 2125261 tgccgctttt gtccagttcc cgtccgcatc aagggcaatt tttttcgcag gcccttttgc 2125321 ttcttctttt atatcatcct gcttttctgc gacatcctta acgaacacag caagacgtct 2125381 cggtgtattg aagagtttca cttcaccgtg agtaatattt ttttctttaa gccagcctgt 2125441 cagcttgtcg ccaagctgaa ccatgctttc attcaaaaag cgcgccggca tttcctctaa 2125501 tccgatctct aaaagtaaat cctgtttact catgagaaga accctcccct ttaagcattg 2125561 ggaaccctag tttttctcgt tcctcatagt aggtttttgc tacttttcta gctaaattcc 2125621 gcactcttgc gatatagccc gtccgctcgg taacagagat cgcacctttg gcatcaagca 2125681 ggttgaaagt gtgcgagcat ttcagcacat agtcatatgc tggatgaaca agtccgttgt 2125741 ccatttgctt gatcgcttct ttttcatatg tgctgaacaa ttggaacagc atatcgacgt 2125801 ctgatgtttc aaacgtataa acagaatgct catattcagc catcatgaat aaatctttta 2125861 ctgtaaaccc tgacgtccat tccaagtcaa acacgttttc tttatcctgg atataagacg 2125921 cgagacgctc aattccatac gtaatctcta cagaaacggg tttacactct aatcccccga 2125981 cctgctggaa atacgtaaat tgtgttattt ccattccgtc aagccaaact tcccagccta 2126041 gacccgcgca gcctaaagac ggattctccc agttgtcttc aacaaagcga atatcgtgct 2126101 caagcggatc aattccaaga gcacgcaagg aatccaaata cagctcttga atgttatcag 2126161 gtgacggttt aataatgacc tggaactgat gatgctgata cagtctgttc gggttctccc 2126221 cgtagcggcc gtctgccgga cgtctggaag gctctacata agccactttc cacggctcag 2126281 gaccgatact gcgcaaaaat gtatacgggc tcatcgtgcc ggctcctttt tctacatcgt 2126341 aagcctgcat aagcacacag ccctgactgg accaatgctt ttgcaaggtt agaatcatgt 2126401 cttgaatatt catttcaagc acctccactt ttctttcata agttgactgc ggcagcaacc 2126461 aaaaaactcc cgtctctatg cttgccagcc gcaaacatag ggacgagagt tctcccgcgg 2126521 ttccacccta gttgctgaga acaaaatccc agcctctttt ttaaaattgc tcaagaatgc 2126581 ctttcgttgc gtgctcatcc ttagcttaca ccgccctaag gtcgctttca tgaggtaaac 2126641 gcaagtactt ctttctctca ctgcaacata ttttataata aatgatcata taaaaagatg 2126701 gaccaaatgt caacttttgt tttcacccat aagatgtttc atgctttcca tttgatctaa 2126761 aaagcgcttt gattttaaat acaatcccga atattcttcg taatataaat caatcacttg 2126821 ctttaattca gcttttgttt cctcttttaa ggacacattg ccgagtctcg acagatcaaa 2126881 atagtaaaag agccttaaca gccttgccgt ttgcggttta atcggtatcc tgtaaggatc 2126941 tttttcaaaa cagcggtggc atataaaacc attatcacga acagagaaat gaaaggttcc 2127001 gtcttggctt ttacaatgta cacaatgatt cagctcagga tacaggccca tgacaccgag 2127061 catcttcatt tgaacaatga aggtgataac atccggatct gttccttcat tcaactgttt 2127121 taatgattct aatatgaatt caaataaata aggatttggc tttttttctt ctgtgcctct 2127181 gtcgactaac tcagcaacat aggcagcata tgctgttaaa aacaagtctt ccctgatgcc 2127241 tctcatgctg aggatcattt ccccctgctg aagcgttccg aggcccgatg ttttttgcat 2127301 taagaaagaa ccatacaaaa agggctggct gactgctgat aaacggctgt tcggtttttt 2127361 ggcgcctcgt gccataacac ctatttttcc gtgttctctt gtcagtaatg ttacgatttt 2127421 attcgtctct ccgtaatcat ttgtgcgaag aacgatccct tcacattttg tcagcatttc 2127481 cgcaccttcc tcaagcagga gcggccaaga ggtttataaa attggataat caaatcgggc 2127541 tagctcatct tctagttctt cgggtctttc catgttctct ttttccagtt ctttaaaaag 2127601 aagatacgta tcaacatttc ctgtttgaga aaatacgttc caggtaaaat tcaacacaag 2127661 aaacccacct ttctgtagtt aaactagctt acctaaactc caaattctta cctttatctt 2127721 gaccagatgt cctccatttc atgttaaaca aaatttgcta atgtatccct gttcctgtga 2127781 gataatgaca cacacgggaa gagattaata ttcgtcctct ttaaagccaa aatcgcgaag 2127841 ctgggacatt ttattacgcc agtctttctg cactttcacc cacaattcaa ggtagacacg 2127901 ggagcccaac agtgcttcaa tatccgctct cgctcttttt ccaacctctt ttagaaggct 2127961 tcctttttta ccgatcacga tgcctttctg ggaatcccgc tcgaccacaa tcgttgccgc 2128021 tacgtgcaca gaaccgttgt cctgcccttt gatggattcg atggccaccg caatgctgtg 2128081 cgggatttct tctctcgtca aatgcagcac cttttccctg attaattcag aaatgataaa 2128141 tcgttcaggg tggtcagtta cctggtcact cggatagaat tgcggccctt ccggcaaata 2128201 cgcttcgatc tgcgcgagca aggtttcgat gttatttcct tctaaagcag aaatcggaac 2128261 aatttcctta aaaggataac gtttgcggta ttcgtcaatt agcagaagca attggtcggg 2128321 atgaatttta tcaattttgt ttacgattaa gaatacaggc gtagacatcg tctgcaattt 2128381 ctcaatgatg aattcgtcgc ccttcccgta gccttcctca gcattgatca taaacaagat 2128441 caaatcgact tcttttaatg tattttgcgc cactttcatc ataaagtccc caagtttatg 2128501 cttaggttta tgaatccctg gtgtgtcaat aaaaatggtt tgtgatgtgc ctgtcgtcag 2128561 tactccttgc accttgtttc tcgtcgtttg gggcttatcg ctcatgatcg cgattttttg 2128621 tccaatgact ctgttcaaaa atgtagattt tcctacgttt ggtcttccaa taatggatac 2128681 aaatcctgat ttaaagcttt cgttcgtcat gtaaatcctc cgatgaaaat gcgcctggca 2128741 ataattcttc cacagtcatt tcttttattt gtccttgtaa attagtcagt acgacaataa 2128801 cgtcttttgt gcaaagctca gaaatcacct gtcggcaggc tccgcacgga gatactggtc 2128861 caggggtgtc agccgcaacg gccagcatct gaaactctgt atccccttca gaaacagctt 2128921 taaataaagc ggtacgctcg gcgcaattgc acatgctgta tgccgcgttc tcaatattgc 2128981 agcctctgta cacttttcca tccttggtaa gaagagcggc tcctacttgg aatttggaat 2129041 acggcgcata tgccatatca cgcgctttta aagcttctgt tattaattct tgtctgttca 2129101 tgtgtacatt cctctcttac ctataatggt accgctatca ctttatattt tacataatcg 2129161 cgcgcttttt ttcacgccca tttctaaaaa tgtaaaataa atgtaagaat tttcagccat 2129221 tacagctttg gcaaaaaaat aagtaaacca atgatacacg aaatcacggc aaaaacgcaa 2129281 acagccccgg cggcagcgtc cttggccgct ttagcaagag ggtgatgttt gtcagttatt 2129341 aaatcaaccg tatgttcaat ggctgtattt aaaagttcaa gcgaaaacat accacctatc 2129401 aaaaggaata taatcatcca ctcaataatg ctgagctcta caaggaagcc gcaaatgaga 2129461 acagcgcagg cggctgcggc atgaaattgg aaattccgct ccgtccgcgc tgtttcccat 2129521 atgccccggc ctgcatgcac gaagcttttg aagaatcgat tcagctcatt tctatgatct 2129581 tttgagtcca taagcgtcca gcaattcctt ttgcttagta aacatctcct cttcttcctc 2129641 tttcgtcata tggtcatatc ctaaaaggtg cagaaatccg tgtacagcta gaaatccgag 2129701 ctctctttta aaagaatgat tatactcctc tgcctgctct cttgtgcgat cggcactgat 2129761 gataatatca cctaaaaccg gaggcatttc ggcgcccacg atttcgatct cgccttctcc 2129821 ctcttcttca agagcaaatg agatgacatc tgtcggagca tcctttcccc ggtattcttt 2129881 gttaatctga tgtatgtcat cattggaaac aatcgtgaca gaaacttcag cctgatcctg 2129941 aacgccttca cgctcagcgg caaattgaag cagattttct acttctttga gcatctcttc 2130001 tgagacgctt cccgtttcat caacgatatc aatcagtaaa ctcatctatt tcaccttctt 2130061 agtagcctcc ggatattcaa tccgggagtg gaaaattcct tttaatgttg cacagagcgt 2130121 ttttgcgatt gtatccagct ctttaaatgt caaatcgcat tcactgaact gtccgtcctg 2130181 aagcttatcg gatataatac cccggacaag cttttcaatt cgttcaggat ttggattgtg 2130241 catggatctg acggccgctt caacactgtc ggccactgat ataattgcgg cttcctttga 2130301 ctgcggcttc ggtcccggat aacggaactc ttcctctgta atctggtcgc ctttttcctt 2130361 cgctttatag taaaaaaact ttaaaagcga ggttccatga tgctgctcag caatatcgac 2130421 aagctctttc ggaaatttat agcttctcag catattcgca ccgtctgtcg tatgcgagat 2130481 aataatattt ttgctcaact gaggtgacag cttgtcatgc ggattgtcaa tattcatttg 2130541 gttttcaata aaatattgcg ggcgctttgt ttttccgaga tcgtgataat atgcgccgac 2130601 tcttgcaagc aaaccattag ccccaaccgc ttcacaggct gcctctgata aattggcaac 2130661 cattacactg tgatgatatg tacctggtgt ttccgtcagt attttgcgca atagcggatg 2130721 gttaggatta gacagctcga gcagcctcat ggtggataaa atgccaaagc ccgtctcaaa 2130781 aaacggcatc agaccgatga tcaatacaga tgaagcaaac cccgacacaa cccccatgag 2130841 cattaacgtg ccgatttcaa gacccgacag cgcagtgttc tggatcaata ataaggatag 2130901 aacgacaacc atattaataa acgccacgaa aagtccggtc tgcaaaatct ttgatcttgc 2130961 attgtgtttt cctaaaaata atacacctga aatgccgctg atcaaataat aaatccctat 2131021 gacataattg aatgttcctg tcacaccctg attaaacatc atacttccgc aaatcgcaag 2131081 aatgatactt cccaaaatgg caatgcgttc attcatcagc agtttgatta agatggcgcc 2131141 ggccgcaatg gggaccagat agccgatatt attatactcc atcttctgaa acaaactgac 2131201 aacctccatg atcacaagca aaagtgttgt gattatggag aataacagaa tggattggtt 2131261 tttaaacttc agattttgtt tctgtttttc aaaataatat acaagtgttg caatgaaaag 2131321 tccgatcata atcaatagcc cgctgatcgg tttaaagaga tttgagttat ttaataaccc 2131381 ggtcagctca agtttcctgt acacttcccg atcaatgagg tcattttctt ccacgagcac 2131441 ttgcccctgt ttgatttgaa cctgctggac attatctgag gcttcctgcc gttttgcctc 2131501 tgttgctttc ggatcgaaga cgtaattcgg aataatagca aaacgcccga tttctgtcgc 2131561 ggctcccaag tatttagacg gaatagaatt gctctttagc tctttttcta ccttatcctt 2131621 tgcatcagat agtttatccg aagggatttc actgctcatg accgtattta ccgcggtaat 2131681 gaccgtatct ctgacaaaag aaaagtcttc actgtctgct ttcagcaatg tcttgatgga 2131741 atcctccgat atagaatcat tcacatctga tgtcaatttg tcctttacag atttgaccat 2131801 tgatttttcc gatggtgatt tactgccttc ttccgatgat tttttcactt cactaatact 2131861 gtcgaatatt gatgacacaa ggtcaatccg attgtctgta tattcttttt ttaatgtata 2131921 ttgatcttca accgcgtcct cagcggcttg ctttttttcc tctgtggctt tttgatcttc 2131981 tacggttgcc ggagcgtaaa tggtcttgtc gctgactgaa aacaggtcta aatcaagtgt 2132041 ttccggctta acatgtacaa agagcaaagc aaacataatg gcagccagca gaagatacag 2132101 cagtacatgc atggagcggg catttttaaa actgctccat ttttttgagc tgcttttggt 2132161 cttagccttc tttttcaaca caagaacctc ctcttgaaac atcaagccca taagcaatca 2132221 taaaaatgac ccgataacgc gcgatcgggt cattcagcat taattttgct tatcgtatgc 2132281 ttcaataatt ttcgcaacaa gcggatgtct gaccacgtct gtctggtcta gctcaatcat 2132341 agaaatgccg tctattcctt tcagcatctc cttcgctact gcaagtcccg atttgacgcc 2132401 tttcggcaga tcaatttggc taacgtcacc tgtaatgatc attttagagc caaaacccag 2132461 tctcgtcaaa aacattttca tttgagcagg cgtggtattc tgtgcttcat caagtataac 2132521 ataagcatca tcgagcgtcc gtcccctcat atatgcgagc ggagcaattt caatgatgcc 2132581 tctttccatc agacgttctg tatgatctgc cccaagcaca tcatggagag cgtcatacag 2132641 cgggcgcaaa taaggatcta ctttttcttt taggtcacct gggagaaaac caaggctttc 2132701 accggcttcc acggcaggtc ttgttaaaat gatttttttg atatgtccgt tttttaaagc 2132761 atggactgct tttacgacag ccaggtacgt tttcccggtt cccgccggac caatgccgaa 2132821 tacaaggtca ttccgcttca tagcggccac gtattcccgc tgtcccattg tttttacacg 2132881 gattgatttg ccttttgcgt tttttgtaat ttcttcttca tacatgcttt caaagtattc 2132941 aagttcattc ttctttgcca ttttgatggc gtaaatcaca tcacgttcag agatctctat 2133001 ccccttgcga attaaagcga ggagcgatcc cagcagcctg tctgcaatct gaaacgattc 2133061 atcatcgcct gaaacataaa tcgtctcgcc gcgcgtaatg atatttaaat tcagatcttt 2133121 ctccatcaat ttcaaaaaag aatcttggtt cccgaagagt gaaagcgcct cgtccgggtt 2133181 tttcagtttt tgattcatcg caagtaaatg ttctgtcatt cttcagtctc cctgacaata 2133241 ggtgtggttt gaacgatatc ttctataact tggtagagaa taatcaactt tactttacca 2133301 ttctcaacag tctggtgcaa aactttttca cttttcacct cgccgttttc gcctatttta 2133361 tcctctacat cctgtttacc caatttaatg ccttcttgaa ctgcttcttc ttttgtatat 2133421 tttcgcaaag cctcttcact ttctctcgtt tgctctttga cataggatac agggagctta 2133481 aatccgagaa aatgaagcga atgcttttct tgttctgttt ttggatgctt caattcctct 2133541 tttttaaacg tcatccccca gatcgggatt gccaaagaac caaaagaaag cttgtgcttt 2133601 gtccttactt tgcccgtata gacgttaaat aatgtttcaa gcgggactgt cacttctgat 2133661 ctataccagg tttctccata aatttctgct tttgaggcga cttcctgctg atggtcttcg 2133721 ctgccgatca gtcccgaaac aagcagctgt cccttttcaa catgatcgtg tatggcggcc 2133781 atgggctgtc ctttttgcac aaacattctc gtaatggttg ctttcttttt ggcgacaata 2133841 ttgcgcgggc taacatattt ttctttttcg ggctcatttt tctccacaac tttcatatga 2133901 atggtcgtcc ccttcagatc aactccgacc caagtgatat tgtctattcc attggttaat 2133961 gatttctgta ttttttcggg cgacatcatt aaaaactgca gacggccctt tttgacgccg 2134021 atttcattaa gatgctgcct catttgatgt tctgtttcag gcttagcgcc tgtcacatca 2134081 attttccaca ccatattgga cagcaaaaac aaaagaatga aaaaaatcgc aaaaccgatc 2134141 gtaaacccta tattcagctt tgatttcagc aacaggaagg gaaatccctt ccgattgata 2134201 aatcgggctt tacatttaaa tttacttctt acccgccgaa aggcatgtac atcctgaagc 2134261 tgtatatata acgatacggc ttctttcttt tttttgacat gaaagaccgg aatcccctgt 2134321 cttgtgcatt cattaaggag ccgctcaatc cctcttcccg tcaattcaag ctggacctta 2134381 cccgaaaaaa aagacagcca tttatttttc acaacatttc cccctcggct ttatgactca 2134441 acatatcgaa cgacatcaat cgtaccctcc aaaagtatct cttccggaag aatcgccttg 2134501 atgacaaaat ttttaccaga tatgatgcac tggccctgct tcagcatcag ccgcacttca 2134561 ttctcactga aaagcaaaag gcctctgtgg ttttctatgt agatatgaag tctgccaacc 2134621 attgtaatcc tcggcagatc catcataacg tccgggggaa tttccaatgc tcttgtcagc 2134681 caagctttca tacgattctt tctttgcccc atacaaaaag aacccccttt catctcatat 2134741 gtatgatttg aaaggaggtt ctaacacttt aatttttacg ggccgggcgc atcgtacggt 2134801 gaggtttttt cgcccgtgga ggtccgaaca cctctcctag aacgatcccc tgtacgacgg 2134861 tgtctttatt cacctgaagc attttttgtt ttgtgtatac tgttttttgt ttggcagcag 2134921 caagatctcg ttccagccct ttcaggtttc ttgctgtttc cctgcgtctt tcttccgctt 2134981 cccgtcttgc ctgttccata cggttaggga taggtgcagg ggcatcttct tttgactgct 2135041 tcttttgagg agaagcagat tgcacgtgtt gaggtttttt tcttttttgg ctgttttgct 2135101 tttcttcttt gctctttttg ccgaaaatcg cagaaatgat tccgatgatc gctgcaataa 2135161 taagcggatt ggtcagtaaa tcttccatca gcgttctccc ttcttagaga gattatgatt 2135221 tgcggtcttc atccgaaggg tctttcgtca gcttgccgaa tgaatcacgc atttctgtgt 2135281 cagcatcgat gttcttgata ttcatgtaat ccatgacgcc aatattccct tcacgcaaag 2135341 cttctgccat cgcaagcggc acttccgcct cggcttctac tactttcgcg cgcatttctt 2135401 ctacgcgggc acgcatttcc tgttcttgag cgacagccat cgcacgtcgt tcttccgctt 2135461 ttgcctgcgc gatgttttta tcagcctcgg cctgatcggt ttgtaaaatt gccccgatgt 2135521 ttttgccgat atctacatct gcaatatcaa ttgagagaat ttcaaacgca gttcctgagt 2135581 ccaatccttt tccaaggact gtctgagaaa tcatgtcagg gttttcaagc acttttttat 2135641 gattatcaga tgaaccgatt gtagaaacga ttccctcacc tacacgagct acaatggttt 2135701 cttcccctgc tcccccgacg aggcgctcga tattcgctct tactgtgatt ctcgctttcg 2135761 ctttcacttc aatcccgtcc attgcgacgc cggcaatgaa cggtgtttca atcaccttag 2135821 gattaacgct catttgaaca gcttccaaca cgtcccggcc tgcaagatca atggcagcac 2135881 agcgctcgaa tgtgagttca atgttagctc gctgagcggc gataagcgcg ttgacgactc 2135941 tgtcaacatt acctccagcc agatagtggc tttcaagctg gtttgttcca acattaagtc 2136001 ccgctttatg cgctttaatc agcgggttaa caacccgatt cggaatgacg cggcgaagcc 2136061 tcatcccaac tagagtgaaa atgctgattt tcactccggc tgccaaagct gaaatccaaa 2136121 gcattacagg cacaaatgta aaaaatactg ccaaaacaat gatcgctact gcgacaattg 2136181 ccagaatcat aagtgttgac ggatccatat aacttctcct cgtttctatt taaatttctc 2136241 tcacgacaat gcgtgagcct tctactttta tcacttttac ttttttatct ttttctgtaa 2136301 acgatccctc cgatacaacg tcaaggcgtt catcatcaat aatcacggta ccggaaggac 2136361 gcagcggtgt aaaggttata cccacttttc ccattaagtc cgtgcgcgtt tgatttgaaa 2136421 cgtagccgct ctccgtgttt gtagaatcat ttaatatcaa tttcttaaag aatttcatac 2136481 gctttcccaa cacccttgtc agtaaaataa aagctgtaat cgaaacagct gaggcgatca 2136541 agagagaaac cgccatgaca gtgaagctcc ccgcggctaa aaacaggctc gcaataatcg 2136601 ctcccaagcc cagtaatcca atgattcctc cgggaagaaa aatctcaagc agaatgagaa 2136661 tcacccctgc tataaagagg agaaccgtct catacccggc aaggccggct gcaagatgcc 2136721 cgtaaaagaa cagcaataac gcaatgagtc cagccgttcc agggaggccg acacccgggg 2136781 aaaaaagctc taccgtcaga cctaaaaaag cgattgtcag cagaataggg acaatgaccg 2136841 gattcgtcag ccatcttgcc gtcttttccg caaagctctc ctttgcatag ctgatctgcg 2136901 ccttttcgaa cccaagcttc tttacgagcg tggacaaatt gtcagcagtg ccttctgaat 2136961 agcctacctc aatcgccttg tctgcgttaa gtgtcagcag atctccctta ggcgcgccaa 2137021 cttccttggc atctatatct gggtcagcca ttgcgagcgc atattttgga tcgcggttat 2137081 ttttcactgc ggcatcttcc atctctgcca gccaaagtga ttgagctttt tggtcagcgg 2137141 cattgccttg gccatcaaca atcgcggcgg ctcccatttt tccgccaggc gccatataaa 2137201 tgtgatctgc ttgaagtgca atatatgcac cagcagacaa cgcgcgtttg ttgacatatg 2137261 cagttacggg gatctcgctt tcggttatca aatcggccat atcaatagca gatttgacca 2137321 atccccccgg ggtattgata tcaagaataa tatggtctgc atgtgcatcc tttgcgtctt 2137381 gtaacgaacg ggacaaaaac gaggcgagac cctgttcgac atttttttca accgggatca 2137441 cataaacagt ttgtttttct gcttttgcgt tcagctgtac gcctaataaa gaaagtaaaa 2137501 atatacccaa aagagcagca cggaatcctt tgatttgaag caagggcggt gtatccctcc 2137561 ttccttttat aataagtgcc ttctcttcat acgtaacaaa tgtatcaaag gtttcatttt 2137621 tttatgtata aaaaaagaca tctctcttag aaagatgtcc ttttctttgc catttaagac 2137681 agttgactgc tcacaagctt attaattaaa cttccgtcag ctttaccttt tactttaggc 2137741 ataattgccc ccatcacttt gcccatgtcc gcttttgagc tcgcaccgac ctccgcgatg 2137801 gtttcattta cgattgtacg cagctcttct tctgacagct gctcaggtaa ataaacttct 2137861 aaaatgtcca gctctttttg aactttatct actaaatcta aacgattagc gtttgaaaat 2137921 tcctggaggg agtctttacg ttgcttaagt tcacgagaaa ggacagtgag ttcctcatcc 2137981 tcggtcaaac tgtctttctt aagcttaatt gcttcatttt gaagtgaagc cttaaccatt 2138041 cgaacgacag tcagtttgtc tttctcacgg tttttcatat acagcttcat atcctggttg 2138101 agacgctcaa gaagactcat aaatccaccc tcttttagaa tttgcgtttt ctagcagctt 2138161 cagacttttt cttgcgcttt acgctaggtt tttcataaaa ttcacgcttt cttgcttctt 2138221 gcaaagtacc tgtctttgat acactgcgtt tgaagcgacg aagagcatct tcaagcgatt 2138281 cgttttttct aacgaccgtt tttgacattc tctttccctc cctccgaata caccaatcga 2138341 ctacctttaa gttacacata taaacatgta ctttgacatt ataatataag ccatcagtca 2138401 ggtcaactaa gtgagttcac ttttccgtca tgagtgcgac tgcctgtcta tataatgaaa 2138461 gaaaggggtt ggtgaatagg atgttaattc tgattagctt tactgctctt atattattct 2138521 ttctcgcagg catgaacatg cttcgaaagg gcttaatttc aatggcgtac tcaaaaattg 2138581 aagaacgttt gcttttattt acagaccatc cgttaaaagc gtttcttatc agtattgtat 2138641 ttacggggat acttcagagc agctcagcct ttatggtcat tgtcatcggc tttgtaagtg 2138701 cgggcgttct ttcttttaag cggacgatcc cgatgattct ggggacaaat gttggctcta 2138761 cttttacaac tgaatttatt gctatcaaaa tggatattgt gatttgggtt cttttaatag 2138821 gaggtttatt gttttttctg actggcaggt atcctttgaa acagctggga acaagcttcc 2138881 ttggactggg catcatcttc ttttgcatca gcggattcag ccatcttgcc gggccgctga 2138941 caaagctgaa aacgggcgcc gacgttctat accatgttaa cgattcaaac tggtccgctt 2139001 tgctcatcgg catggtgtta actgccatca ttcactccag ttctgtctgt atcggcattt 2139061 tgatgagttt tatgaatgaa gggattatcg gactgacaca ggcgatgagc gtcgtactcg 2139121 gatcaaatat cgggacatgc attacagctg tcatggctgc tgtatccggc ggatatgcgg 2139181 cgaaacagac agcatatgcc catgtggtat ttaacgtgct aggggtggct ctagtattgc 2139241 cttttctgac cgcagcgacc ggctttgtag agcagttatc acctgatccc gcacaaaaga 2139301 tcgcgcattt cagcctttta tttaatgtgg tgacagctct tttatttctt ccgcttacaa 2139361 acttgtttta ccgattgatt caccttctta tcccggctaa ataaaaaaat cggtacattt 2139421 taatgcaccg attttttagg ttaagaagac aaacgcatgt gttcagttat ttcatcctca 2139481 accacacgga caaactgtcc ttcgttgtaa ggataacctg cttttaggat tttgactttt 2139541 acgattttgc cgatcatatc ttccgtacct ttgaaaacaa ccttcatata attgtctgtg 2139601 taaccgacaa acatattttc ttcttctgtt tccttaaacg cttcctcagg gataatctca 2139661 agcacttcat tttcatactg agaagcgtat tcttttgcaa gctggtcaga aagagcaatc 2139721 aggcggtgca cacgttcgtt tttcacgttt tcatccactt ggtcttccat tcgtgcagct 2139781 ggtgttcctg tacgcttact gtaagggaaa acatgcagct cagagaattt atgttcttta 2139841 ataaagttat aggtttccat aaattcttct tctgtttctc cagggaaccc gacgatgaca 2139901 tcagaagtaa cagctaagcc tggcagtgct tttttcaatt tatttaaacg gtctgcaaag 2139961 aattccattg tatatttgcg tctcatccgt ttaagcactg tgtttgatcc ggattggata 2140021 ggaatatgca aatgattcac tatcttatct gagcggtcta agacctcgat cacttcgtca 2140081 gtgatttggc tggcttcgat tgaagaaatt ctgatccgtt tcacgccttc cacacgggtg 2140141 tctaattcgc tcaaaagctt cgcgaagttg taatctttca tatcttcgcc gtagccgcct 2140201 gtatgaatac ccgtaagaac aatttcctta tatccggcat cgacaagctg ctgcgcttgt 2140261 ttaatgactt cttcagggtc gcgggagcgg agcaggcctc tcgcccacgg aatgatacag 2140321 aatgtgcaga aattattgca gccctcctgt attttcaatg acgctcttgt gcggtccgtg 2140381 aaagcaggca catcaagctc ttcatatact cttgctttca tgatgttgct gacgccatta 2140441 atcggctggc gttcttctcg gtattggtca atgtagccaa gcattttttc acggtcctgt 2140501 gttccgacta caatgtcgac accggggatc gccataatct cagcaggtga ggtttgcgcg 2140561 tagcagcctg tgacacagat gacaccgtca ggattttgac gaatggcgcg tctgatcact 2140621 tggcggcttt ttttatctcc cgtatttgta accgtacatg tattaatgac atatacatca 2140681 gctgtttgtt caaagtctct tctttcatag cccgcttctt tgaaaagctg ccagattgct 2140741 tctgtttcat aatggttgac tttacagcca agcgtatgga aagcaacagt tgccattact 2140801 gatcacctct taataactct gtttgataag aaatcgcact caacgcgtat agcggagcgg 2140861 tttctgtcct taaaattctc ggtccaaggc cgcacgtcac accgtcttgc tctgtgagcc 2140921 gttcaacctc cgcttctgtt aaaccgcctt cgggaccaaa tacgatcaat agagatgatc 2140981 ctttcggaag gctgcttaca atcgcgctga atgcgcttat ttccccttgc ttcgatgact 2141041 cctcgtatgc aacgacacat ttatcgaaat cctgcatcct ttgaagaagc tgctgaaaag 2141101 aatggacatc catcactcgc ggcacttcgt tacggtacga ttgctcagcc gcttccttcg 2141161 caattttcgt ccatctttcc cgctttttct ttgccttttt gtcatccagc ttgacaacag 2141221 aacgcgcggc ttggaaagga ataaaggcat gagctccgag ctcagtcccc ttttggataa 2141281 tccattcaag cttatctcct ttcggaaggc cgctcgcaat atagaccttt atcggaagct 2141341 ctctgttttc attcgtccat tctatcacaa ggcaggacac tttatctttg gaaacagatt 2141401 gaagttcaca ttttgcctcg aagccgtctt gagagcagca gataatctga tctccctcat 2141461 tcattctcat cacgttcaca atatgatgaa cttcttcgcc ggtaatcgaa aaagtcggcg 2141521 cttcctctat ttgctgcttc gtgagctcga taaaatatcg ttgcatacgc tgtgacacct 2141581 actaactgtt attttttcgc aataatgctg acccaatctt ccattgaaag gatttctaca 2141641 atggtaaagc cagcttgttc cagtgcttct tttacttctt gttttttatg accgatgatt 2141701 cctgacgtaa taaagtgacc gccttctttt aacaggctgt acgcttgtga agtaaagcga 2141761 agaatgactt cagccaaaat gttggccaca atcacatcat gttccccttc aatcccgtct 2141821 aacaaattgt tttgcttcac ttgagcaata tcgctgactt tgttcagctt gagattgagg 2141881 cgtgcacttt ctacagccac gggatcaaga tcgtaggcat gaaccgattc agcctcaagc 2141941 attgcagccg caatacttaa aattcccgaa ccagtgccga catcaatcac cttatcaccc 2142001 ttttgcacaa agcgttcaag cgcctgaatg cagagtacgg ttgtcggatg tgtccctgtg 2142061 ccgaaagcca ttcccgggtc catttcaata atcagttcat cagtatggac cggcgtatat 2142121 tcctcccacg tcggcacaat tgtaaacttt tcagaaattt tcacaggatg ataatacttt 2142181 ttccaggcag tcgcccactc ttcttcattt acttcagaaa tagtgatgtg gtttctgccc 2142241 aaatcaatat tgtaaagaag gagattatta atcgtttctt tgatgccgtc tacagtttcg 2142301 cccagaaaac tgttaaccgg cagatatgct ttgacaatga caccctcatc tgggtaatca 2142361 ttggggtcga gctggtagat ttccccgtac acattctcac gttctttaat taaatcaagc 2142421 gggtcctcta tcacaacccc acttgcacca gcttcatgca atatatttga gataggttcg 2142481 accgcttcat gtgttgtgtg aatgcttaat tcggaccatt tcaaaactac caactcctca 2142541 tccaataatt aatcgccttt aaacgcgcgt tttaccttgt caaagaaact catttcctgt 2142601 tcgtcaggca ggtttccgct gacttcggca aattcgcgga taatgtcttt ttgtttatca 2142661 gtcagatttg tcggcgtaac gacgcggacg acgatatgct ggtcaccctg tccatagcct 2142721 ctgacatttt gaacgccttt gcctcttaat ctgaatttcg ttcctgtttg tgtaccggcc 2142781 ggaattttca atttcacttt tccatgcagc gtcggcactt ctacctcatc tccaagagca 2142841 gcctgagcaa acgttaacgg catttcacag taaatatcat cgccgtcacg ctcgaagaac 2142901 tcgtgtgcgc gtacatggaa cacgacaaat aaatccccgg cagggccgcc gtttattcct 2142961 ggttcaccct gtcccgagag acgaagctgc tgcccgtcat ctacaccggc tggaattgtc 2143021 acattgattt tcttgcgttt tttgattttt cctttgccgc cgcagtccgc acatttgttt 2143081 ttaatgattt tgcctgtacc ttcacagtgg tggcagaccc gtctgttaac gacttttcca 2143141 aacggtgtat tttgctccac gtttaactgg ccggagcctc cgcagtggga gcatgtttct 2143201 ggatttgttc caggtttcgc acctgagcct ttacatgttt cgcacgtttc ctcgcgggga 2143261 atttcgatgg ttgtttcttt accgaaagcc gcatcctcaa acgacagggt catcgtatac 2143321 tgtaaatcag caccctggcg cggagcgttt ggatctcttc gtcttgtgcc tccgccgaat 2143381 atacttgaga aaatatcatc gaaaccaaaa ccgccgaaat cgccgccgcc aaaacctccg 2143441 ccgccgaagc cttggttagg gtcagtgtga ccaaattgat cgtaatgcgc acgtttttgg 2143501 tcatctgaca gcgtttcgta tgcttctttt acctctttaa atttttcatc tgatccggct 2143561 tctttgttaa tatcaggatg atattttttt gacagcttcc gataagcttt tttaatttca 2143621 tcctttgaag cgctcttact tactcccagc acttcatagt aatcacgctt actcatctcg 2143681 cttcactctc ccgaatttct cacataaatt agattgtatc attttgaatt atgatttttc 2143741 aattcctttt atcccgggca agaaaaaaag tcaaagccaa gagatgcctg actttgactt 2143801 tctaatcatt gaatcagatt atgaaatgtg ttcttttcgg tcagctccgg aagcggggct 2143861 gacactaaaa agaacttatt ttttgttttg gtcgtcgttt acttcttcgt attcagcgtc 2143921 gacaacgttg tcatccgctt tgccttcagc gtttgctccg ccttgagctt gctgtgcttt 2143981 agcagcttct tcataaagct tcatagaaag ctcttgaacg attgtttgaa gctcatcttt 2144041 tttcgctttg atctcttcaa attcgttttt ctcaatcgct gcttttaaag cgtctttggc 2144101 atcgttggct tttttcactt gttcttcgtc cactttgcct tcaagatctt ttaatgtttt 2144161 ctcagtttgg aaaacaagct gatctgcttc gttgcggact tcgatttctt cttttttctt 2144221 cgcatcagcg tcagcatttt cttccgcttc ttttaccatg cgttcgatct cttcatctga 2144281 gagacctgaa gaagatttga ttgtaatgtt ttgttctttt cctgtgccta agtcttttgc 2144341 tcttacgttt acgataccgt ttttgtcaat atcgaaagaa acttcgattt gaggcacgcc 2144401 gcgcggtgct ggcgggatat cagtaagctg gaagcggccg agtgttttgt tgtcggcaga 2144461 cattgggcgc tcaccttgaa gaacatggat atcaacagct gtttggttat cagcagcagt 2144521 tgagaacact tgagatttgc ttgttgggat cgtcgtgttg cggtcgatca gttttgtaaa 2144581 cacaccgccc attgtttcga taccgagaga aagcggtgta acgtcaagaa gaacaacatc 2144641 ttttacgtca cctgtgataa cgccgccctg aatcgcagca ccaagcgcta caacttcatc 2144701 cgggtttacg cctttatgcg cttcttttcc agtttctttt ttgattgctt cttgtacggc 2144761 agggatacga gttgatccgc cgacaaggat gactttgtcg atttcgcttg cagaaagtcc 2144821 tgcatcttga agcgcttgac ggacaggacc cattgtgcgc tctactaaat gagaagaaag 2144881 ctcttcgaat ttagcgcgag ttaatgtaag ttcaaggtga agcggtcctg cttctccagc 2144941 tgtgataaac ggtaaagaaa tttgcgtaga agatacgccg gaaagatctt ttttcgcttt 2145001 ttcagctgcg tctttcaaac gctgaagcgc cattttgtct tttgacaaat caatgccgtt 2145061 ttcttttttg aattcagaca ccagatgatc gatgataact tggtcaaaat cgtccccacc 2145121 cagacggttg tcgccggcag ttgaacgaac ttcgaataca ccgtcgccaa gctcaaggat 2145181 ggaaacgtcg aatgtaccgc cgccaaggtc gtatactagg atcgtttgat cttcatctgt 2145241 tttatcaagt ccgtatgcaa gcgctgctgc agtcggctcg ttgatgatac gttctacttc 2145301 aagacctgca attttaccag cgtcttttgt tgcttgacgc tcagcatcgt taaagtatgc 2145361 aggaactgtg ataactgctt ttgatactgt ttcgccaaga tagctttcag cgtatgattt 2145421 aaggtgttga aggatgatag cagacacttc ttgtggagtg taatcctttc cttcaatttc 2145481 aactttataa tcagtaccca tatgacgttt gatagacata attgtgttag ggtttgtaat 2145541 agattggcgt ttagccactt cccctacttg acgttcgccg tttttaaatg caacaactga 2145601 tggcgttgtg cggtttcctt cagcgttagc aataacttta ggctcgccgc cttcaagcac 2145661 tgccacacat gagtttgttg ttcctaagtc gattccgata actttactca cttgaataac 2145721 ctcctgctat gtaattattg attcactttg accatggaag ggcgaatgac gcgatccttc 2145781 agcttatagc ctttttgcat ttcctcaaca acaatgttgg agccgtagtt ttcgtcttca 2145841 gcctgcataa cagcttggtg cagattagga tcaaattcct gccctacagc ttcgatggct 2145901 tcgacgcctt cttttttcaa ggcttctacg agctgacggt ggaccatttc cattccctgg 2145961 agcaaacttt tcgtctgttc attgtcggct tcaacctgaa gcgctcgttc aaaactgtca 2146021 agagccggca gcaaatcagt cacgatattt tgagaacggt atttttggga cgcttccatc 2146081 tctaaacggc tgcgtcgttt atagttttca aagtctgctt gaacacgcaa aagtttgttt 2146141 tctttttcct caagcaaacc ttgcaattcg ttaatttggt tttgaagaag ttcgctttca 2146201 tttgtttctt cctgctgttc atcagcggca gcttgttctt caatgatttc ttgctcttct 2146261 gtttcgtttt gttcaacggt ttgtttttct tctgacattg tgttcacctc cctcaaagtg 2146321 taaggagaag gacaggtgct gcccttcgat aaaatttgcc aaaattccct tattcatcat 2146381 acagacttgt taatgctttt gacaagtccg aagtcacatg ctgaagcagg ctgacaaccc 2146441 tggaataatt catgcgggtc gggccgataa tcgcaattga gccgatctgc ttctggtcta 2146501 cggaataaga agccgtaatc agactgcaat tttccatctc ttcatagtcg ttttcttttc 2146561 cgattttaat cgaaattccc gtgtgcgggg attgaaccag ctttaaaaca tcctgttctt 2146621 tctcaattaa tgaaagcagc gaccgaactc gggtgatatc atggaactca ggctggttca 2146681 gcatattgat tttcccgcca aaaaacaact tttcaacgtg atttgtggaa tgaaaggttg 2146741 aacgaagcgc gtcgagtata ttgtcatagt ttttaatgtg ctgtcttagg tacatgacaa 2146801 cttctttaaa tatgcgctca ttcagttcat ccattggaac gccgcttaaa cggtcgttca 2146861 gtatatttac cagtttttca atatcagaca gatccatttt ggtcggaaag ttaatcgttt 2146921 tgttttccac atgccccgta ttggtaacga gaatcgctac cgccatatca ggctgaatcg 2146981 gaatgatttg aatctgttta aggtaattct cactcaactt cggcccgagt acgatggatg 2147041 tgtaattcgt cagatcggac aaaatttgcg ctgatttttg aactgtcttc tccagctcga 2147101 aaattttctc tttgaagatc gagtggattt ggtccaggtc gcttttcgtc aatttgacgg 2147161 gtgacagcaa atggtcaaca tagtaccgat accctttttc tgacggaaca cgtcctgagg 2147221 atgaatgggt tttttcaata aagcccaatt cctccaagtc agccatctcg tttcttattg 2147281 ttgcagagct aaatgtgatt tcatcttttt tcgaaagagt tcttgatccc accggctgtg 2147341 ccgatttaat aaaatcgttg attataacct gaaggatcag cagctgacga tttgttaaca 2147401 tcatcatcac ctctgttagc actctcaata agcgagtgct aattctataa caaaagtatc 2147461 aaaccacaag aaaaatgtca attataactc acccaaaaaa gcgccaaaaa cttcattgcc 2147521 taataatttc ccttgatgag tcaaataaac ggcagactcc gaattgtgaa tcagcccttt 2147581 ttcagcgagg tcttttaaca cgcttgggaa aagtccatcc agggaacggc cgtatttttc 2147641 tgcgaatcgt tttttgctga caccggctgt ttttctcaaa cctaaaaaca tttcttcctc 2147701 aatctgttct tctgttgtca cttcatgtgt atctctgtac ggaaaaccct tttcagctat 2147761 caggtcaatg taatgcttaa caggtccgac gttcactgtt cgtgtgccgc caatatatcc 2147821 gtgagcgcca gctccgaaac cgaaatattg ttcgttgctc caatacgtta gattgtgctt 2147881 agattccatg cctgccttag caaagttgct gatttcatat tgatgaatgc cgtgagcttc 2147941 catcttgctc atcactattt catacatttc agcttcctgc tcctgcggcg gaagatgaag 2148001 ccgccctttt tgcatcaaat tataaaatac cgttttcggt tctacaataa gggagtaaac 2148061 ggaataatgc tcagcgtcca atgataaagc agtgtttatg gaatgttcca gatgcttgag 2148121 ggtttgcccc ggaagcccga acatgagatc aagactgata ttctcaaaac cgatttcccg 2148181 cgctctttca aaagaggtga atacatcttt ttgcttgtgc actcggccga ttttttctaa 2148241 cagatcgtct tcgaacgttt gcacaccaaa gctaaggcga tttacgcctg cttcttttaa 2148301 tatttttaat ttctctgcgg acaaatcgtc cggattcgct tcaaccgcaa attccgataa 2148361 gtcgcttgag ggctttagca cgcggttgat catatccatc agctttttaa gctgttcctc 2148421 agacagggag gtcggcgtgc ctcctccgat aaagattgtt ttgagatcag gctgcccggt 2148481 ttttgctatt gtatttatca tttcctgttc gagtgcgttt aaatactcgt cgactggctg 2148541 actttgaata aaatatttat tgaaatcgca gtagtggcaa atatgctcac aaaatgggat 2148601 atggatataa gctgatttca acggattcac cttctttaca gaaagaagcc gcagtacaag 2148661 actgcggcgg cttctattgt tttttcggac tgtcgtccat tttcagaact gccataaatg 2148721 cttcttgcgg cacttcaact gagccgacct gcttcatacg gcgctttcct tctttttgtt 2148781 tttcaagaag tttccgttta cgcgagatgt cccctccgta acatttagcc aatacgtttt 2148841 tacgcattgc ttttatggtg gagcgggcca cgattttctg gccgattgcg gcttgtaccg 2148901 gaacttcaaa ctgctggcgc ggaatgagtt ctttcagttt ttcaacgatc acttttcccc 2148961 gttcatatgc gtaatcacga tgcacgataa aggaaagggc atcgattttt tcaccattca 2149021 gcataatgtc cattttcaca agcttggacg gtttgtagcc gatcagttca taatcaaagg 2149081 acgcatagcc tttagtgctt gatttcagct gatcaaaaaa ctcatatacg atttccgcta 2149141 atggcatatc ataaatgatg ctgacacggt ttgcgtctaa atactgcata tcaatgaaat 2149201 tgccgcgttt tccttggcaa agctccatta cagcgccgac atagtcattc ggcaccatca 2149261 tcgtcgcttt tacgtatggc tcctcaaccc tttcgatctt ttgaggatcc ggcatgttgg 2149321 acgggttgtc gacaacgacc ttttcgccgt ctgtcatata cacgtcatag ataacgcttg 2149381 gcgctgtcgt aatcaggtcg atgttgaact cacgctcaat tcgctcctga atgatctcca 2149441 tgtgaagcat gcctaaaaat ccgcagcgga acccgaatcc aagcgcttgc gaagtttccg 2149501 cttcatattg aagggaggaa tcattcagct caagcttttc aagagcttcc cttaaatcat 2149561 tatacttcgc tgtatcaatc ggatacaaac cacagtacac catcgggttt agcttgcggt 2149621 atcccggcag cgcttcttct gcaggattgg cagcgctcgt tattgtatca ccgacacgtg 2149681 tgtcaccaac atttttgatt gaggcagtca ggaagcctac atcaccgacc gtcagttcat 2149741 ttgtcggagt tgctttcggc gtgaacacgc ccacctctgt tacttcgaat tctttgccgg 2149801 ttgccatcat tttgattttt tgtcccggct ttaccgttcc ttcaacgact ctgatataag 2149861 ccacgacacc gcggtaggcg tcataaagcg agtcgaagat cagcgctttg agcggcgcct 2149921 ccggatctcc ggtcggagct ggcacctttt ctacgatttg ttctaaaatc tcctcaatcc 2149981 cgataccggc ttttgctgaa gcaagcacgg cttctgatgc gtcaaggccg ataacgtctt 2150041 ctacctcttg gcgcacacgt tcgggctcgg cgctcggaag gtcgatttta ttgatgaccg 2150101 gaaggatttc aagatcgttg tcaagcgcta agtagacatt ggcgagcgtc tgcgcttcaa 2150161 tcccctgggc tgcatccacg acaagaatcg ctccctcgca ggcagcaagg cttcgggata 2150221 cttcatacgt gaagtcgacg tgtcccggcg tatcgattag atgaaagata tattcttctc 2150281 cgtcttttgc tttatattta agctgaacag agtttaattt aatggttatg ccccgctcac 2150341 gttcaagatc catagaatcg agcaattgtt ctttcatttc tcgttgagtg attgccgacg 2150401 ttttttctaa aatacgatcc gctaaggtcg attttccgtg gtcaatatgg gcaatgatag 2150461 agaaattccg tattctcgat tgcctctcta aacgcttttc tttatctgtc acaatctatc 2150521 actcctacta ttaaacgcaa aatacactag cttagattat atcaatagga ttgtaaagat 2150581 tcaatgtaaa acaagaaaga gaaaagttcc ctatcatatc tgggttgctt ttctctttca 2150641 cgtacttatt gattcatatc ccgtatccat tcatacattg actgggcagt attggttacg 2150701 gtgtccgaaa gcgcttttcc ggcttttgaa aacatattga atgtctccac cttttccagc 2150761 tctttttgtt tttctactaa atcttttgcc gtgactgttt ctcctaggat tgaggcttct 2150821 ttttcattat cttttccgtc ggtgagcgta aacgccccct tcagtgaagg gtcatgatag 2150881 cctttcatac tcagcatccc gtggtttgcc tgctgcatgc cgaacagaac gcctaaaaac 2150941 atgatcgtga caagcagtaa gcactttcca aagtatgcaa tcaaatcaac cacctatttc 2151001 ttattgtttt ttcgtctccc cgctcgctgc gttgaccttt tcagcatccc agtacatttc 2151061 gctgaatacg tccgcggccg cgttagccgc acgctgcagc tcttcgagat tattatccac 2151121 tccgccaaac tcgagcaaaa gcgctctatc ggttaaatcc tgattgtaaa caccattatc 2151181 gcctggcgag cctttggaaa agacacctgt gctaagtccg gggtattttt tctccatcag 2151241 tttatgaagc tcactcgcaa ttttatagtt ttcttcgaag tttttgcttt ttttcccgac 2151301 gacaaaggct accctggcat agcttttccc tttaatcgtt gcggttgtgt cttttttgcg 2151361 ccgagagtct ctgtggatgt caatgatata ttgcagattt ttgtttgaag cgagggcgtc 2151421 tttcacgacc ggccttgatt catcatagga cctggcatag tttaagcctt ttttattcaa 2151481 ttttgactgt atatcggttt tattcactgt ggctccgatt ccctgggatt caagcgcttg 2151541 tccgaacata tctcctacaa gcgtgacatt ggctttagaa tggcgcgcca tgtcaggatc 2151601 ggtctcgcct tttaatagag ggagatatga ttccgtattg tgcgtgtgat agataaacac 2151661 gaccttttta tcacctgttg tttgtttcgg cggatctttt tgcgcattat ctgattgcgt 2151721 ttgctgtttt tcaatctctg ccaaattcgc ttctctttct tcctccatca ccttagacgg 2151781 cggcggcgat tccgcaggca tattcgtata atccgttcct tgtccagcta acaaaatctc 2151841 ggtatcaaat tgtgcaaatc ctggcagctc ccgaccgaga aagctccgcg gatcttcgag 2151901 gttaatgctc gtcgccagct ttaaagaaag acgagaaaga tgaaatgagc tgtctgtttg 2151961 agagaggtca gaagcgaaat aatggttttc catctgcagc aaatgtgcaa atacgtcacc 2152021 cggcaattct tcagcaatcc cataaaaaga gtcagacgac ggcctaagtt ccggccggag 2152081 agacgtcagc acaccggata gaacaaaaat cacgataagg cttacgataa atagaaagat 2152141 ggcttttacc gctttccctc catttaccgc aacaacaatc tgtctgtttc tgcgtttatt 2152201 tctcattgaa tccctccagc gcttgtctag taattactct atgaacaagc tagaggaagt 2152261 agaactgttt agtgattgta ggagcctttg ttttcttgtg acactttttc atgaagcgct 2152321 gtgtttaatc cgttcgctaa aacatttgcc atatcgtcga taaatgaatc gacttccttc 2152381 ggtgtaacca ttaagttgtg ccctaaaggc gaaagcacct cgtgaatgag ctgccgtttt 2152441 tcatcttctt gaagggttcc gacaatacct aggaacgatt ggcgctgctt ttgatcggga 2152501 agatcgtctt cagtgagcac tttctttttc ccaaacgtca tgcctgccgg aacaagcgat 2152561 cttgatggcc tgttatcctt catttctctg ccaaaatgtt ttaatatgta gtccaccgtg 2152621 tcgctggcaa ttgtcacggc atcaactact gtcggaacac cgatagcaat caccggaaca 2152681 ccaagcgtgt ctttgcttaa atcttttcgt ttattcccca ctccagaccc cgggtgaatg 2152741 cctgtatccg atatttgaat ggttgtgttg accctttcca ccgcccgcgc cgccaacgca 2152801 tcaatggcga tgacaaaatc aggcttcgat tgctcaatca cacctttaat aatgtcactt 2152861 gtttcgattc ctgttatccc cattacaccc ggtgcaaaag cactgacagg cctgtaaccc 2152921 tcctgtacgt tttccggctg aagcttaaac aagtgccttg ttaccaacag attttctact 2152981 gccatcggtc caagcgcatc aggtgtcacg ttccagttgc cgagcccaac gatcaaacag 2153041 ctcgcatctt ttgagatatt aaggttttca agaaaagctg agaattcctc cgcaaagaca 2153101 gcagagacct tctcctgcat ttccgaatca ttctccctga ttccctgtgc ttcaagcgtt 2153161 aaatagcgcc cttctttttt tcccgaaagc tctgcgcctt cctttgtaac atcaactgtg 2153221 cggattttaa tgccgccgtg atcacgctct ttttcaataa agcctttaat ttcttttgtc 2153281 ggcacagcct gctgattggc cattgcttcc ttcgtttcca ctgccaaatc ggtccgtatc 2153341 aaatactgat tcacatccag ctcactcttt ttcatacagg ggcctccttc acattaagta 2153401 cctatattgt tgccatttgc tgaataaatc atgctaaaaa gagaaccttc aatgaaaaat 2153461 actttacatt tatattgcaa tctaaaggtg tgtttgatag aatacaattt gttctattgt 2153521 gaagaagatt taaccttaag acactgtgct acaggttgta tcttaggagg tgaaacacat 2153581 gccaaacatt aaatcagcga ttaaacgtac aaaaacaaac aacgaacgcc gcgttcataa 2153641 cgcgacaatc aaatctgcta tgcgtactgc aatcaaacaa gttgaagctt ctgttgccaa 2153701 caacgaagct gacaaagcga aaactgctct tactgaagca gctaaacgta ttgataaagc 2153761 agtgaaaaca ggtcttgtac acaaaaatac cgcagctcga tacaaatcaa gactagcgaa 2153821 aaaagtgaac ggactttctg cataatataa aaacgatcct caataatggg gatcgttttt 2153881 ttcatttctt tttaacagct gtaaaaggaa cagttcgagc aggagctgct tgtccttttt 2153941 cccggttttc atctcatagt ccatgacggc aagctgttca ataattaaac ggagctcctc 2154001 ctctgaaaaa agccttgctt gatccatcgc cagctttacc cgaaatgggt gaacttttag 2154061 attagaagcg atttgttttt gtccgtatcc ctgttccgcg aagtacttcg tctgcagaat 2154121 cagccggaac tgattcgaaa taagcgccat aattttgatc ggttcttcat tttgttttag 2154181 caaatcataa aaaatttgca gactctctgt tcgttttcgg ttgacgattt tattgatcag 2154241 ctcaaaaata ttttgttcaa ggcttctagc aacaagcatt tttacatcat ccagcgtaat 2154301 ttcttcacga tctccaataa acgtgcagag cttttgaatc tcctgaaaaa tcgatgacag 2154361 atgaccgttc acaagcagaa ccaaatgctc cgccgcttcc gtgccgattg ttttctgctc 2154421 tgtttttgca aggttgacag taaagtctgt cgtttccttt gcatttaatt ccttcgcctc 2154481 catcataaac gcgtgcttct ttaacgcttt cgtcagcttt tttcgctcat caagcttttc 2154541 atacggagca agcaggacaa agactgtgta aggcgcaggt gattgtatat atgattcaag 2154601 cgcactgacg ttgtgctcaa ttttttcttt tttcttttca cctgttaaaa aatatggatt 2154661 tttcacaatg acaagacgcc gctcccccat aaacggaaac gtttcagcat ctgcaatcgc 2154721 ttgatccagc gggtcctctt ccagatcaaa aacggacaga ttgaaatcct ttgtctcctg 2154781 atcaacgacc gtctgtctga tcctgctgac ggtttcttgc agcagatatg tctcttttcc 2154841 gtataaacaa taaaccggat ggacctctcc ttttttcagg cttttccaca catcaaatac 2154901 cattgttgta cgacttcctc tctttcatca tccccttcta tcctaaattg agtttgcaaa 2154961 atagtaaaga ggaagcctga ctgctgcttc cccatttata ttaaacgcct gttcgcaagc 2155021 ccccgggaca gcttgtaaaa aggcgataat caccagaaca gaaaacgtta ccttagcttc 2155081 tagatttttc aaaacaattc cattatactt aagtcagtca ggagggataa agttgaatga 2155141 ttttgaaaaa aacgttcaaa gcaaacgaaa tgatgctgta gattcagctg ttggttttgt 2155201 tgtgtccttc ggatttttcg ccttcttgtt tgtcatggca acggttattc acctagttgg 2155261 ttcataacag cgactgcccg ggctgctgat ttctcggcag tcttttttag ttcgtctctg 2155321 ttatatctga tgtatcatat ggaggataga cagaaaaggt tccaactctg tttttgtatc 2155381 tatattggat cgttccgttt tgatctgttc gcagcacgcg gatagaatgt ctctgtaata 2155441 gttgcagaac tttttgatga ggatgatggt accgattgtt tttcccggct gagataatgg 2155501 ccgttttcgg ctgaagctgt tggatgaatt cttcaccggt agagcctttg ctcccatggt 2155561 gccccacctt taacacatct gcttttatat tcggaaacac gttcatcacc tcttgttccc 2155621 cttctttctc cagatcaccc gtcaagatcc agctcatacc gcccgtctcc atccacagaa 2155681 cgagagatga attatttttg cttgccggat caggtgcttc cggtgacagt acatggaact 2155741 gcaaatcctt tatttgcaac acatcgcctc gcttcacctc ttcaattgcc actccctctt 2155801 ccctggctgc ctgcagcact ttctcatctt taggttcaga aacgaaccct ttcggaatca 2155861 cgaggcgctt tactttatga tgcttcagca gaatctccgc ctctccgata tgatcttggt 2155921 cagcgtgcgt cagaattaaa gcgtcaagct gcttgattcc cttagcagtt aaaaacggaa 2155981 tcagcacctt ttcccccagt gaaaacggat gctgtttttc gcgccaaggc tctgacgagt 2156041 aagacaaagt gccgccggta tcaattaaga cacgaccccg ctgatgcgga gcacctacaa 2156101 acatgctgtc accctgtcca atatctatca tatccacttc tccttcggaa ctaagacacg 2156161 gatatataaa gagcagaaac atcaccgtgc agcaaatgcc tccggttacc atcaactgcg 2156221 acaaggagcg tttttcaatc gccataagca ataggatgat cgtgactgtg aataaaaaaa 2156281 gcaaaacagg tgcaggatgt gcgatcataa tcgtgaacac atcaacatct gcaatgtttg 2156341 tgattaacct attgatccag cttatcaata aatcaaacca gctgaaaaac aatctcccaa 2156401 acgaagcgga aagacttaat agaagaacac ctgctacagc tcccggcaaa atacagaagg 2156461 tataaaatgg taccatcaac atattcatcg gtacgctgat gatagaaaac tgatgaaaat 2156521 gatataggag aatcggaagc gagcccagct gagcgatgag tgatacaatt gtcagctgcc 2156581 ccaaggaggt tttaacctgc tgaaaaatag aagaggatag aattaaagaa aaactgacgg 2156641 cgaacgatag ctgaaaaccg gcttcaaaga gatgataagg attgaagagc agaaggacga 2156701 tgtacgaaag gcaaattgca gttgcagagc ggacacgcca tttgacaaga cttccagcta 2156761 agtaaacacc cgacatgaga gcggcgcgta gcactgaagg agcagcgccg gtcaacatca 2156821 catagagcgg cagaaataac agcaacagaa ttgacgcctt ttctctagtt ataccaaggc 2156881 ggatcatgat ataaaacaaa cctgctgtca aaatccccac gtggagtcct gatattgcca 2156941 agagatggac aacaccaagc ttttgatacg cggtaagcac ttcatcctcc acgtaaaatc 2157001 tgtcaccaac tgtaagtgcc tgtacaatcc ctgtcgaatc aggaggcaga aggctgtttg 2157061 tgaatgatat gatatgtttt ctcaagctga gcaccttgta cttgaaattt tcaggttcgc 2157121 tgcagttttg gatagacgtg acagagtagt tccaatgaat atgctgccga taaagatact 2157181 cgttataatc aaatgcaccc ggcacagttg cgtgattcgg ttcttccaat gtaccagtca 2157241 actcacatga cattcctggt tctatgtata acagctgttc tttttcacca gcagactgaa 2157301 tgcgatacgc agcagcccat ttttccttat caggtgtctc aaccatcata gacatacggt 2157361 cgccgtcaat tttgggaata gtgtcaatca ctgccttgaa ttgataggtt ccctgccgat 2157421 aggaagagac attctgagaa tctgtgactg catacagtac aaaaaacaat ataaaagaga 2157481 agaaacaaac aataataaga aaagcgtgcc tcgttttgat taaaatgatg aggagaaaga 2157541 ggatgaaaag aaaaatagcg gggaaataag cggcggcagt aattccagcc gttgccgaag 2157601 ctgccgccat aggcaataat aagcgcgaat tacgcattca tcacacgtag ctcgtgaaaa 2157661 gtgtattcgc ctgttcatgt atctttttca attcttcctc cgctaaaccg gcatcagcca 2157721 atttccctat tagacccgct acaaatgaaa gcttttctct gtttttcaga tcaacgatca 2157781 tttcatcgag ttcaacctgt tcaacagtta cacccgcctg ttcaaataat tcctgcgcat 2157841 acggatgtgt tttgtaatcc tcagcataat aaaccgtttt gataccagct tgaataatag 2157901 atttgcagca ttgaatgcac ggataatgcg tcacataaat ctcggctcca tcagtcggca 2157961 ccccaaactt agagcattga agaatcgcat tcatttcagc gtgaatggtt cttgcgcaat 2158021 gatcatctat cattaagcat ccttcatctg cacaatgtac gccgcccgcg attgacccat 2158081 tgtagcctcc tgctatcatg cgtttgtctc tgactatagt agcgccgaca gataatctcg 2158141 gacatgtgct gcgcagcgcc aataaatggc tttgagccat aaagtattga ttccatgaaa 2158201 ttcgttccac gttgttccct ccaaatgttg tgttgcctga cctttagttt acctatcata 2158261 atgcatgacc gtcaaatcac tttactgtaa tggaagactt tattttctca aatgactttt 2158321 cacctattcc tgaaacctta gtgatatctt caattgtttg gaaacgaccg ttttcctccc 2158381 ggtatgcaat aatagcttca gctttggatg gccccacccc tgagatgcct tgtaactcct 2158441 ctaaggttgc tgtattgata ttcaccagcg ctcccttccc tccatcgctt tggacagacc 2158501 ctccgccacc ttgctgcact gctgtttcct ctcccttttt cgggatgtac accactgtcc 2158561 cgtcctgcag aatctccgcc aaatttactt gcgcttcgtc tgcttgttca ctggtcccgc 2158621 ccgctttctc aattgcctga gatactctgt cccctgttcg catttcataa acgccaggat 2158681 gctgaacagc acctttgatg tctatcacaa ttgtttcgtt tgactcgtcg ttgtttgctt 2158741 cctgctttac cactgtattt tctgtctctg ttggtacagc ttgcttcacc ggctctttat 2158801 ttttccctgt ggccagaaag atcataatcg ctgtgaaaac agccgcagaa gccgctaaaa 2158861 taattgcttt cttatgctga ttcaaccaat tcatcgtgca tgttccccgc tttcgtcata 2158921 ttttattttc ataacacata tggtttagag gataatagct caaaggaggg gaaaccattg 2158981 aagataggct ttatcggcac aggaaatatg ggtacgatcc ttatcgaatc atttattgaa 2159041 tcaaaagcgg ccgatccctc aaacatgaca atcacaaacc gcacaattga aaaagcgttg 2159101 cacataaaaa accgctacaa cagcataaac gttaccgaaa gtctcgaaaa gctcgtttct 2159161 gaaaacgaga tgatttttat ttgtgttaag ccgcttgata tatatccttt actggcaaga 2159221 gcgttacctt atttaagaaa agatcatatt ctcatttcaa ttacaagccc cgttcaaacc 2159281 gaacagctcg aacaatatgt gccgtgtcaa gtggcgcgag tgatcccaag tattacgaac 2159341 agagcgctgg caggtgtttc tctcgtcact ttcggcacaa gctgcggcga atctgcaaaa 2159401 gcgaaaatca atgagctgat gcagcatatc tctcatccgc tgcaaattga aagtgacatc 2159461 acgagggttg catcagacat cgtaagctgc ggccccgctt ttatgagcta tctgattcag 2159521 cggtttatag atgcagctgt ttcggaaaca tcagtgtcta aacaggacgc gattttgatg 2159581 tgtaaggaaa tgcttgtcgg aatgggaaaa ctgttagaaa ccgaattgta taccctgcct 2159641 gcattacagg aaaaggtttg cgttaaaggc ggtgtaacag gagaaggcat taaagcgctg 2159701 gaaagcggtg tgcaggatat gtttcaccgg gtatttcaaa atactcatat gaagtacgag 2159761 gaggatattt ccgcagtgaa aaagcagttt catgtgtaga cgagtatgtc atacgttcgt 2159821 ctgtactgca aaagcataaa aaagcatttt aaaaaaccat cgttttagga aacgatggtt 2159881 tttgatttct gcgccttgaa aaagaggcgt tctgattgtg ctgatggctc ggtatccgta 2159941 aaatcagctg tcacgcgatg gagctgaaag ccgcagttct taagcatttc ttcgtattct 2160001 tccaccggga acgttctttg ctcgtgtgtc tcatcaaaac gatcatacgc ttctccgttc 2160061 cacacaaaaa acgacatatc atgaatgaca gaaagctcgt cacttccggc aaagctctgc 2160121 caaatatagc tgatatcttc gtcctggtca gcaaatgtgc tatccggaaa gacttccgca 2160181 attttaaaag atgaatgaac atcaaacagc aggatgcctt caggctttaa tacccgaaaa 2160241 acacttttaa aggtttcgat cacatcattt tttgttttta aataatttaa tgagtcacag 2160301 catatcacaa cagcgtcaaa ttgaccgtca aagccggtaa tctctctcat atcctgctga 2160361 agaaataaaa taggctggct actcgatacc ttttgctggg cgaaagaaag catctcttcg 2160421 ctgagatcga tgcctgtaac ctcgaagcct ttttcggcaa gccggatgga gatttccccc 2160481 gtgccgcatg ccagatcgag aatacggcct ttttccggga gagatgcttc aatccatttt 2160541 gtccattgat cgtaaggcgc gtgtgacatt agctcgtcat acacgcttgc aaagccttga 2160601 taaatcattg attcattcca aagtcaagat ctgcgagcgg agcgtctccc cacagctttt 2160661 caaggttgta gtagcttctt tcatccttgt ggaagacatg gacaactaca tcgcctagat 2160721 caacgagaac ccatcttgct tcatcaaagc cttccatctt tttgacttga atgccgtttt 2160781 catcagcttg atccttgatt tcacgggcaa tcgcctgtac ctgtttatct gaatttccgt 2160841 ggcagatcag aaaataatca gcaaccagag aaataccttc catatccagt gctaaaatat 2160901 cctctgcccg tttatcatcg caagccgcag ctgcgatctt taaaatggac ttttggttca 2160961 ttcacaaatt cctcctgttc agctgccaga cacaagccag ttatacgtta aaaatgtgtc 2161021 tggaaaaacc ggttgatttt ttttcataag aaaaaccatt gtatttttaa tggactgaat 2161081 cagcgcttga ttcaaatctg tctcagcaag cttacgcacc tcatcgacac cgggaaatgc 2161141 ccggtttggc tcaatgtaat cggcaacgta aatgactttt tctaaaagtg tcatgccggg 2161201 gcggcctgag gtatgatacc taatggcgtc aagaatgtct tcatcttgaa cccctgcctc 2161261 tctttggacc aaataagcgc cgaccggagc gtgccagagc tccggattat gatccaataa 2161321 atgcgcaggc attttttcac gcgcaataat ttgtttcatt tcttctttcg ggcggaattt 2161381 ggcgtaatca tgaaagattg ccgctatttc cgctttttta gaatcggctc caaaacgctc 2161441 cgcaagttcg atcgccgtgt tcatcacgcc aaccgtatgg atatatcggt gttcggtcaa 2161501 ttgctgcttc acgcatgcaa gtgcctcctc acgattcata taaaccattc tcctctacat 2161561 acttcttcac tttatcaggg attaagtagt cagtgggctt cttgctttta aaccgttccc 2161621 ttatcatagt tgatgatacc tcaaattccg gaacgtctgc aaagagaagc ggataagggg 2161681 tttcaacatg aaaaccgggg cgctttactc caataaattg aatgaggttc agcagctcgt 2161741 ccagcttata ccatttcggc aaatattcaa tcatatcagc gccgataata aagaacagct 2161801 gatcatttgg ataacgctgc ttcagtaaag aaacggtatc aaaggtatat gatggccctt 2161861 ctctttccat ttcaacaagc tccagcttaa aggacggatt agattgaatt gcaagcttta 2161921 gcatttccac gcgatgaaag ctgtcggtat agtcttcgtt ctgtttatgc ggcggaattt 2161981 gattaggcat aaaccaaatt tcatcaagcc ccgcctggta cagcacctca ttcgccatta 2162041 agaggtgacc attatgcgga gggtcaaacg tgcctccgaa aattccgatt ttcttcattt 2162101 caaccacctt taaggaagct cgatttgttt attttccttt gattccttat ataacacaat 2162161 cgtattgccg attgtctgca ccaattgaga gcggcttcct tttacaagag cttccgctac 2162221 atcgttttta tcctcttcgc aattctgaag cacgctgact ttaatcagct ctctcgcttc 2162281 aagcgcctca gcaatttgtt taatcatgtt gtcgtttact ccgcctttac ctacttgaaa 2162341 aatcggcgtt aaatgatgcg cttttgaacg caaaaaacgt ttttgtttac ctgttaacat 2162401 tctgttcctc ctaattttcc tattacaata gatctcattt tttcaatatt aggctcttgt 2162461 ccagtccaca attggaaaga caatgctgcc tgttcaacaa acatgcccac accatcgagt 2162521 gttttcaagc ctttttggct tgcttctttt aaaagtgccg tctgtattgg attatacacg 2162581 atatcacata cgacggcact gctcgcggca cgctgtaatg aaagcggcac atcgtccacg 2162641 ttcggataca tgcccacaga cgttgtatgg atgataacat catactgctc aagacgttct 2162701 tctgcttctt ttatgcttaa tacttcttta ttgtgaaacg agggagtagc ttctgtaagc 2162761 cgctttgctt tttctaacgt ccggttgcaa atgtcaaatt ttttcggggt atttcggaca 2162821 attgttgtaa aaatggctct cgccgctccg ccagcgccga tcattaagaa tgacagttca 2162881 gagatgggct tgtctaatac cttcattaat gacttcacga agccttcccc atcggtattg 2162941 tatccgacaa gcttatctcc ctctcttctg accgtgttta cggcaccgag cacttttgca 2163001 ctctcatcaa tatgatccaa ataatccata atggaaacct tgtgcggaac agtcacattg 2163061 attccttgta cgcctagagc tcttattcct tttaccgcat cctccagatc attctcttct 2163121 accttgaagg catgataatg tccgtcaagc ccgaggtctt tcaatgatgc gttatgaata 2163181 tcaggtgaca tagaatggcc aataggattt ccgataaccc cgtacagctt tttcatacac 2163241 ctctcccctt ttcttaaatt aatgaacgcc gaacaaatac atgaacgcct tttggcgcgt 2163301 atgcagttac ctttttatca gcgtcatgga cagtaaccca gcctaaccca gagaaaacga 2163361 tatctgtctt tttgtctttt atcgtaaacg tatgggcgac caattcagga aactcatcca 2163421 tttcatcttt acccggaggt gtgagcaatt cccctgcatg cttttcataa agcgcgtctg 2163481 cattttcaag ttttgttcta tgaatcatca gctcattcgg catatagcaa ataaaaggag 2163541 atctttcccc agacacataa tcaaaccttg caagtccgcc aaaatacagt gtttgctgat 2163601 cattaagctg gaatgtgcga ggcttcagct cctttttagg agataatatt ttcaggtcct 2163661 ttttattgac ataatgcgcc atttgatggt tgttgataat tcccggtgta tcataaagcg 2163721 atgaaccgtc atccagcggg atttcaatcg catcaagggt tgtgccagga aattgggatg 2163781 ttgtaataat atcttcttca cctgacactt ctttaataat ccggttaata aaggttgact 2163841 ttcctacatt tgtacatccg acaacataga cgtcttttcc gttgcggtaa tgctcaatcg 2163901 cgtcaattac ttctctgatt ccctggccgc gacccgcact gaccaaaaat acgtcaaccg 2163961 gttttaagcc aagctctttc gcttcacgct tcatccattg gatcagacgc tctcttttca 2164021 gtgacttagg caaaatatcc gctttattgc caactaataa gatagggttt ccccccacca 2164081 agcgctgcag cccattaatc cagctgccgt taaaatcaaa aatatcaaca atttttacga 2164141 ccagagagtc cgtttctcca ataccgtgaa gaatgttcaa aaaatcatca tcagttaagg 2164201 agacatcttg tatttcatta tagtttttca gtctgaagca acgctggcaa atcacatttt 2164261 ctttcgtaag cgatgcaggc ggcgcgtacc ccaaacctgt tttgtcctcg gtttggatcg 2164321 taactccgca cccgatacaa acaacctttt ccatttctta ctcctcccac tgaatgtgcc 2164381 cttttcgttt gagagcactc agtattctgc gttcgacctg gcggttaaag cgcgtaatga 2164441 atccgtcaga ggaagcgact ggcacgacca aaatcgtatg gtagccgttt cggtttcccc 2164501 cgagtacatc ggtcagcagc tggtctccga tgacaacgca gtcctctttt ttcagctcca 2164561 tattgcgcac cgctctatta aaggctttac ccatcggttt tcttgcttta tagatgaatg 2164621 ggattccaag cggttctgag aaaagtttca ctcttctttc gttattatta gagacaattg 2164681 tcactttaat gccgtgttcc ttcatttctt caaaccactc gatcaatcgc ggcgtcgcgt 2164741 tcggcctgtc ccattcaaca agcgtattat ccaggtcagt aataattcct tttacatttc 2164801 gttcctttaa tttctcaggt gtaatatgaa aaatattttt tacaaactcg tcaggtaaaa 2164861 aaaacttttt taacaaaacc cgcacccttc cctttttctt tctttcaaaa tgattgtcga 2164921 aaaaaatcga acttgcgcct aaagaaaaac tgagcaaaaa aatttcgaca aaaattgggt 2164981 ttcttcacca ggtgtggata aatttacaca cactatccac tcttattaca tcactcttta 2165041 gacaaattat aaacacgata ctcacaagtt atccactttt tggtgtggat aacagaacga 2165101 ttgttcttat atgcatttca tggtagatta aagataactt caacctcaga tgaatgcaac 2165161 ttatcattgt atgcgttaaa atcatgaatg attccaactt ttaaggaggt gcctctccca 2165221 ttaattgggt tcctagcatg agaaaactgt ctgatgaatt actaatagaa tcttatttca 2165281 aagccaccga aatgaattta aaccgtgact ttattgagtt aattgaaaac gaaataaaaa 2165341 gaagatcgct cggacatatt atttccgtat cttcttaata ggaatttgtc tattttttcc 2165401 gggcgtattt ccttttttta ctcagatgac tgatattata tcactttggc tgcgcgcttt 2165461 actactattt tcagcaaaaa acacccctaa aaagaggtgt tttaaagggc cggttattat 2165521 gctaaccagt atatgccgcc cacaacaagg agaacaacaa ctaaaacaac aataaaagcg 2165581 tatccatatg ctctgcctgc gccatacatg tgaagcgcct ccttaataag gttttataac 2165641 agcctatgta ggagaaataa atcggactag gcggttgtcc ggctcaacgc tgcaggatct 2165701 gccccgcgaa ctaatttatt aatgttcaac aacagaattt cgtctattgg caataaagaa 2165761 tccacaaatc attgcaagaa tggccatcgc ccaccagaac gttgagatcg cctgatcatg 2165821 atcgatgata atcaaacgaa tgacagctgt gatgccaata taaatgaagt agcgaagcgg 2165881 aaaatgaaag tctgatttga agtatttgat aatcaaagca atgaactcaa agtacatgaa 2165941 gaatataagc agttctccaa gcatctcata atagctgtcc actttgttga acagtgactt 2166001 gtatacgaat agcacaatgt accaagtctc gctgatcaga agtgcgctta aggctaacgc 2166061 cagaaagaac agacagacgt tgagaagcgc ttgtaacagg taaggcacct ttttgaattt 2166121 gttagaaaat ctcatcatgt tgtctcctat ttcaatatat tcgtggtttt tattctcagc 2166181 ctacatcttg gtgttccaaa atcgtagcac aatgtagtac ttagaattct tttgtatact 2166241 gtgaaactgt ccctgcatgc gggacatcat tcgcgcaatg cttctttcac cgagtccgtt 2166301 gctttccggt gttatatctg caagtttaat cgtattgcta acatggatct caaatatctc 2166361 ttgatccgat acaaacgtga tactgatttt ttcttccgga tctgcgtatt tcaataagtt 2166421 tgacatcaca ttatcaaata cacgaccaag ctcctccaaa ttcacgttaa tataggtttc 2166481 cggcagctcg cctgaaatat ggacccgaaa atgctcctga tgaaggatag caatctgatc 2166541 tgatattaga tcgtagatca cttctttcac tgcaacggtc tccagatcgg cctcatattc 2166601 cttgttcagc aggaaatacg caaacagatt gtcagacaag ctttttaatt gcagtgcttt 2166661 accataagca ttggctacat accgatcttt gctggcaccc gcttcgcctc cctctttttt 2166721 ggcaaactcc agattcatga tcagcgacgt cagcggtgtg cgcatatcgt gcgacatttc 2166781 ggtaaccagg ctgcggctct cagcttgcaa ttcctcgata gctttaagtt tatccaggaa 2166841 agctttccgc agatcctcaa tgctctttgc aatcatcgct aattcatcat gcccttttat 2166901 cgtcatctcg tagtccagtt cgcccccttc aagaatatga atctcttgat gaatcgtttt 2166961 aaggtagcga agactttggc gaattccgaa gagaacaatg attaaaaaga tgagggttgc 2167021 cccgagcaaa tccaatgcaa aggccagatc ataatatcgg gaagagtaga aaccgtcgat 2167081 aatgactcgt ccttcaccat cgctaaactt gacaggatgt gaatgatttt gagcgtactg 2167141 agtcagcttt tcctttccat aatccgattc ggaataaata gaatcatatt gcagctcctg 2167201 atccttgaat atggtgaggt taatgtaatt ttcttttttg acccactcgc caaacgcttt 2167261 tctatctgat gtagacaact cattttctga aacgtacttg ctgaattttt gaatgtatct 2167321 tgctgactcc tcgtgataat actcttccga actcagatat ccctcgatca gatcatctgt 2167381 gatcttttgc aacgtcagaa agatcacacc actcacaatc gcagcaacca ttatcagcaa 2167441 agccagtttt ttggttagcg taaatttaag atgcgccaaa tcgatatcct cttccccatt 2167501 cagtttttat ataaaccgga cgtgccggat catcctcaat tttggagcgc agcttccgta 2167561 tatgcaccat caccgtattg ttggaacagt aaaagtaagg ctgtccccac acactctcat 2167621 atatattttg ggcagaaaat attttgttgc gtttgttcat cagaagtttc aggatacgat 2167681 actccagatc tgacaacttg atttgcttct cctctttcca cacctcatta aattcttcgc 2167741 tcactcttag tttgcccccg ataagaaatg tttcttcctg ttccttcttt tcctgataga 2167801 tagtatatct gcgtaattga gcaatcactc tagcgtgaag ttcctcttcc gagaatggtt 2167861 tagtcatata atcatcgccg ccggcgagta atccctcagt tttatcgagt gtactcgatc 2167921 tggccgtcag aaacagaatc gggacgttag aggatttcct gatgtgctga catgtttcaa 2167981 ttcccgaaat gcctggcatc ataatatcca aaataaccaa atcaagcgag tcattcacaa 2168041 gttgcaatgc tcgctttcca tccttggctc ttagcacctc gtaacctgca cgtgtaaggg 2168101 attcctccaa aagatcacca atatcctcat catcctctac gactaatatt cgataggcca 2168161 tgtctctctc acctcatgat tcttgttgtt atttctcgtg tgtccttact atatatcgtt 2168221 catagtaata agtacgttat aagatactac gtaaatctta acaatttatg aaagctgatg 2168281 ctcgccacaa atttgtcaca ttttctaaaa aaaatgatga ctcttcataa attgttaaga 2168341 ttcggtcttt atatttatcc attgtaaggc tcaagttttt cagatccgca ctacacattg 2168401 ccgtgataaa tgggaaagga gtattgatat gattgtacaa aaagaaggac gcgggcaacc 2168461 ggtgagtctg cgggaacggg ttcattttct ggacatcgta cgaggatttg ccttgcttgg 2168521 cattattatt gtcaattatt ttctgatcgt agattcagta aagggattcg aaatggcctc 2168581 cgatgacgta ctgcataagc tggtttcctg gtttgccgaa gggaaattcg ttacgttatt 2168641 ctccttcctg ttcggagtcg ggtttatgat ctttatggat cgagccgcgc agaaggtaga 2168701 gagtcccaac aagctgtttg cccgcaggtt atctatcctg ttgggatttg gcattttgca 2168761 catcacattt gtttgggtcg gtgacatatt ggccttttac gccgtaagtg gcttcctgtt 2168821 actcgccttc tataaacgca cggccaaaac ggtgcttaga tggattatcg cacttatcgt 2168881 gtttcaattc ctgactcctg ttttcacaat gttgtacaat gtcatcaata ctgcagggtc 2168941 aaaaaacccg aatttttcag agtttacttt gtttagccac agcagcctta cctacatgga 2169001 atccatcagc actcggtgga cagatatggt cacgatggct gccggctctt tctctatgat 2169061 ctattccatg tttctcatgt ttctgctggg cgtgtacttt gttaagatgg aatttttcaa 2169121 agacatggaa gcgaaaaagc ctatatggaa gcgtatctgg atcattagca caatcgcttt 2169181 tctaataaca caaagcagta tattactaga catgtttaat ctttctgaga atatgctgtg 2169241 gaaggacatt tcctctgtct tgggtcaaaa tggcggctta accggaagta tgttttatat 2169301 gagcactttt gcaatgctgt ttctatacct tcctcagctg cgaggcccta tgatgatatt 2169361 caccaaagtc ggacggatgt cattgacctg ttatctgctt cactctatca ttggaacagt 2169421 tctgttcctc aggtacggat tcgggcttgc ggatcatatt caatccgccg gcacgttcat 2169481 gttcagtctg gccgtgtact tcgttcttat gagctttagt acattgtggt tgaaacggtt 2169541 taggtacggt ccgatggaat tagtatggcg caagctgacg tacggcaaag taaacgggag 2169601 tcccaaagca actccgctgc attcggaaaa atctattcag aaataacccc cttgcacaga 2169661 ttgcatgact tcaaattagt gttgttgaat gaagcgggca ttaaacggac agatttgata 2169721 tatggactag ttatttttat atcatttagg cttctttggg ctaataaatc caccagagtt 2169781 tactcaatgt gcattgctca tgatcgaatc taaattgaat cttttacgca tgttcatagt 2169841 caaaggcgcc tcattcgact atttttgtaa cttttcgcag gaaaaattcg agaatgatga 2169901 caaatcccgc atacgacact taatacggta gtgaacaata gtaaattagg gttacatgca 2169961 gcttgttttc caatgaaaca aagaaaaaga atcatacaaa aagacaggag aaagcttttg 2170021 aagtatttta acgccaaatt taccgcggaa gaaagagcga tggaatcact tttttgtgaa 2170081 aaggcctcgc agagcagctc gaatgtttta ctgaacgact gaactctata ttttagcaac 2170141 tgagggagtg aacaatcatg aaaactaaaa atgaaccaaa agttattctg gaactagcaa 2170201 aggaatctga tctgccagaa ttccaaaaaa aattacaaga agcctttgcg atcgccgtga 2170261 ttgaaacgtt cggtgattgc gaagatgggc cgattccatc ggacaatgat gttcaggagt 2170321 ctttcaatgc tcccggagca gtggtatatc atattcttca ggatggtaag aatgtcggtg 2170381 gtgcagtagt acgtatcaac agccaaacaa atcataattc gctagattta ttctatgtat 2170441 ctccagaata tcacagccaa gggattggtc tttctgcttg gaaagccatt gaagcacagt 2170501 atccggatac tgtgctttgg gaaaccgtga caccttattt cgaaaagcga aatatcaact 2170561 tctatgtgaa taagtgtgga tttcatatcg tagagttcta caatgaacat cactctaatc 2170621 cgcatatgca tcgcaatgga cgtgaagatg acaagcccct actgaatgat gatgactttt 2170681 tcagatttgt aaagattatg aaaaaaaagg actaaacaat tgaacacggc gagatgccgc 2170741 agagagttgc tggtaacttt tttatatttc attatcagag gaaggtaata atgatgttta 2170801 aaaggtgttt tgatccctgt ctcataaaca ggggtcaaaa cacctttgaa tcatcggttt 2170861 cttttctgac atataccacg cccactagtc cctcaacata gtaaaaacat atcatgagtt 2170921 acaaaagctt ttattcaaag catatgttta ttttatttat acttattttc atcatttttc 2170981 agaattctgg acacaaatcg ggtacctatt agaggccaag gaactctaca tttcattaag 2171041 aaatacgtac tcattgccct gctttaatta attttaagcc ctcgcactat gcccccccct 2171101 gaattaagta tttgatgtaa ctttgaaatt aagtttatga aaatctgtca caaaccctta 2171161 tttcataaca catcatttgt ttcagcttcc ctcgcgaata ccggattaat gctcggcttt 2171221 aagatagtca accaatctct ccgcactgtt cttaacatct tcttttgaaa gatgaagtgt 2171281 cccatattgt gtaaacgcag gaagaaaacg cattcctata tagttagcag tgacttgaaa 2171341 cggtctgata agctcgctga tcgtgatatt atattctccg cctgcttgat aatcagattc 2171401 ctgtgcgcct aaggagatag ctaagagtag ttcttttcca tgcaatttag ttcctccagt 2171461 tccataagcc cagccatgtg ttaacacatc atcttcccat tgtttgagta acgcgggact 2171521 gctgtaccaa tacattggga actgaaaaac gatacgctca tgatctaaca ggagctgctg 2171581 ctctttttct acatcaatga taaaattagg gtattcaccg tacaggtcat gaaccgtaat 2171641 gtctttctct tgctttaaac gattcatcca ggttttgttg acaacagacg tttccaaatt 2171701 aggatgtata acgataacta atgttttcat tagactgatt atcctttctt tgccaattag 2171761 ttattatttt ttacgataat gaattgattc taattttaaa atagcaactt tatttacacc 2171821 tattttatcc tttttcatga attcagggca actaattggg caccaaaatc aatgatgact 2171881 taagacattg ttttgtagaa atccgatata cagaataatc cattatttag aaaatttcta 2171941 ccttttccct caatccgagc tcgctcttca tgcggatggc ctattttaaa ggaataactg 2172001 actatgttca tcagttattc ctttaaaata cgaaagtcta cgatatttcc atatcgatcc 2172061 gcttcaatgt gacagcaccc ctcaagcagc tgttttaatt ttccacgtcc gcgttgtacc 2172121 cttgattttg ctccggagta agaaatgccg agcttttcac tcaactcttt ttgtgataac 2172181 ccctggaaat cagttaactc gagcgcctct cgatactttt caggcaaccg tttgatggtc 2172241 gatcgaatac acacagttgc ttccttggtg aaattttctt cctctgcact gtcattaaaa 2172301 tgtagaacat caggcaatat ttcgcttgtt ttttttgtac ggtaaaaatc aataatcgta 2172361 tttctagtga tccgataaat ccagctgtcg atcttttgtt catcgatcag atttgggaga 2172421 tgcacttgta ttttcataaa tacgatttgc aagaggtcat caacgataga ttgatcgtta 2172481 accctatgtg aaatatatgt ttttaacggc tgatgaaatt gatcccatag atcctctata 2172541 ttcatttgaa aaaacctcct ataattttgc gtctgcttta catttgcttc gtctttttaa 2172601 tcgtaacaaa gagcaaacaa ttgttgaatc aattgtattg cagctgttgc caaaaataat 2172661 gataaaggag aggtttgttg tggagtatac ctatttaggg agaacaggat tgcgggtgag 2172721 ccgtttatgt ttaggcacga tgaattttgg agttgataca gacgaaaaga ctgcgttccg 2172781 tatcatggat gaagcacttg ataacggcat tcaatttttt gatactgcca atatttacgg 2172841 ctggggcaaa aacgcaggat tgacagagag catcattgga aaatggtttg cacaaggagg 2172901 acagcgccgc gagaaagttg ttctggcgac aaaagtatat gaaccgattt ctgatccgaa 2172961 tgacggacca aatgatatga ggggcttgtc tctatacaaa atcagacgtc atctggaagg 2173021 atcactgaag cggcttcaga cagatcatat cgaattgtac caaatgcatc atatcgatag 2173081 gcggacaccg tgggatgaga tatgggaagc ttttgagact caggttcgct ccggcaaagt 2173141 agactatatt ggatccagta attttgcagg ctggcattta gttaaagcgc aagctgaagc 2173201 tgaaaaacgg cgattcatgg gactcgtcac tgaacagcat aagtatagtt tattagaacg 2173261 aacagctgaa atggaagtgc tgccggctgc acgggatctt ggtttaggag tagtggcgtg 2173321 gagtcccctt gcaggagggc ttcttggcgg gaaggcattg aaaagcaatg ccggaactcg 2173381 tacagcaaaa agagcagatt taattgaaaa acatcgtttg caactcgaga aattttcaga 2173441 tttatgcaaa gaactaggag aaaaagaagc aaatgtggct ttggcatggg tgctggcaaa 2173501 tccagtttta actgcgccga tcatcggacc acgaacggtt gagcagctgc gtgatacgat 2173561 aaaagccgtt gaaatcagtc tggataagga gattctccgc atgttaaatg atatctttcc 2173621 cggacctgga ggagagacac ctgaggcata cgcctggtga tacattcatt actcaatact 2173681 gacatttttc ttaaatattt atactgaact atcatattaa gaaagacaag agcatgtttg 2173741 tctcttgtct tttccacatc gtgctgaaaa tgctggctaa acatcgacaa aaatgctgcc 2173801 gcttaaaaaa gaaccctaaa caatagagta actggaaaga caactggctt gatcagcttg 2173861 ggaccccttt cagctgtatt taaatcaatc aaactaatga ttcattggca gtctaaatat 2173921 tattattgtt tctttacaaa atagtaatag cccctgtaat gattgctaac aacgtaataa 2173981 ctaatgatgt aattacagcc cacttaacgg caaacctttg aaatgacccc aagtccattt 2174041 taagcatgct tactagcaat actgttgacg caaccaatgg actcatcaga tgaaccggct 2174101 gccccattat agaagccctt gcaatttcta ctggttctat accatatgct gaggcagctt 2174161 ctgcaaagat aggtaccata ccaaagtaat atgcatcatt tgataaaaca aaagtaaacg 2174221 gaatactagt gagtgctaca ataacgggga aaaaccctcc cattgatgag gggatgatgg 2174281 atattaatga tcctgctatg gcatccacca tctttgtccc ggataatata ccagcaaata 2174341 ctcctgctga aaataccaat aataccacgg ttatggcatt accagaatgc tcggcgattc 2174401 gctccttctg catttttaca ttcggataat ttatagtaag ggcaagaaca aaaccaatta 2174461 aaaataaaac tgacggatgc ttagttccaa gcacaataaa caccatgata cttataacga 2174521 ggaataaatt aagatatatt aagcgtggcc ttttcaattg ttcgctctcc aaagtagcag 2174581 ccatataaga ttgagagctg tcctttgtta tatgtctagg ctctaattga acgatgccta 2174641 ttcgattcct ctctttcctt cccattagaa aagccagaaa tatcacacaa gcaatacctc 2174701 caagcatggt cggaagtaat ggcacaaaga aatctgaagg atccaaaccc agcactgaaa 2174761 tcgctcttgt agctggtccg ccccatggag tcattccgct aacgatactc aacgacagca 2174821 ttgctaatgt cgccataacc atgggattca taccaattct tttatacaaa ggtaacattg 2174881 ctgagactgt tatcatatag gttgttgtac cgtccccatc taaagcgata agcattgcca 2174941 agacggcaga ccctatcgct attttcacag ggtctccctt tactatagat aaaatttttt 2175001 ctattagcgg atcaaataaa cctgcatcaa ttaaaattcc gaaaaaaaga atagcaaaca 2175061 atagcaatgc cgctgaactt gcaactgttt gaattccttc taaaatcatg tcgccaatac 2175121 ccttaccaaa acctccaata agagcaaaaa caatgggagt gatggtcaag gcaacaatag 2175181 gcgagacttt ctttgtcatt attaatattg taaaaacagt taccatcgaa aaacctaaaa 2175241 tagtaagcat attacacctc caagaatgcg ctttcaaatg acttttgatt aacatatctt 2175301 atacggtgta ataagttaaa taaatatttt tttactgtgt ttcaaaaaaa attctatcat 2175361 aactttaaat ggttaccatt tgttcaccct ttaaaaaatc aatgaatgct ttaacgagtt 2175421 tgattcctaa tgatttttga tcgtacatta gccaagtatc tctcattaga ggcttaccct 2175481 tagcattata cagttccatt gtgtacaaat gatcagattc ctgcaggcaa atttctggtg 2175541 ctatggagta accaagacca tgctttacca tctctttgca agtctcttgt cgatccactt 2175601 ccattgcaat aatgggggct tgttttagat tcgtatgcat ccaatcttct ataatcgttt 2175661 ttaaagaagc atccgtttta tatttgataa aaggtaaaaa aggaagttgc tctatcgtta 2175721 ttggtttttt tgagatgata tgtaattttt cccgtgtcag ccgttcctcc acccctttcc 2175781 agcgatggct tcctctcagt ataccgactt gtacaatacc agcatctaat aatttcatga 2175841 catctgtgct ccagcctgtt tgtacactat attggacatt aggatacata gtggaaaatt 2175901 cccttaataa cttagggagc ttatattgag cgaaattgct tgataccccc agccttagat 2175961 gtccttgcac ctctttgctt agattagaga tatgatcttt ggtatcttga agttcctgta 2176021 gcattcttct tgcataagca accaagtgtt ctccttccgc agtaaaggta attcctttat 2176081 gccttttggt gaataattca attccgaaaa tctcctcaat ctttttcaac cgataagtga 2176141 tggaaggctg tgatgtaaat aatcgttctg ctgtttttgt tacactttgt tcttcgtgaa 2176201 gaattttcaa taaaatccaa tctttctcat ccattttcat cttcctttct agtccttctt 2176261 tcacaattat aaaagttttt ttatcgaata ttaagaaaac ttatatttta tttttatttt 2176321 tttaccttct acactaaaaa acataaaaaa tactaccttt aagatgagga tgatgacgat 2176381 ggtcaagacg aatgtaacaa tcatgagagg cggaacaagc aaaggcgttt ttttccacga 2176441 atcagccatg cctaacaata aaaacgaatg ggagcccttt ttgcttgatg tcatgggaag 2176501 tcctgataaa agacaaatag atggtttggg tggcggtaat tcccttacta gtaaagtggc 2176561 aataataaag aaagcatata cttcggatat tgatgttcac tatactttcg gtcaagtcag 2176621 catttcggaa gaaaaggtgg actttaaggg gaactgcgga aatatctccg ctgctgttgg 2176681 tccatttgct attgaagaag gacttgtaaa agcgaaagaa ccaatgactg cggtaaggat 2176741 cctgaatacc aatacgaata aaatgatcat tgcggaagta gaagtggaag acggtcaggt 2176801 caaatatgac ggagatgtta cgatatctgg agtacctgga tctggatctc caatctattt 2176861 aaactttcat gatgccgctg gttcagttac cggtcattta ttgcctactg gaaatagttc 2176921 ggagttttta gatacaagtc aaggccaaat agaggtgtct attatcgact atgcaaatcc 2176981 attagttttt gtggaagcga gcagtatcgg cctggatgga acggaacttg cagaagaatt 2177041 tactgatcta cagttggctc aatttgaaga attaagatcc attgcggcag agaaatgcgg 2177101 ctttgccagt cgattttcag ctacaaagtt atcgccggct gtccccaaac tggctatagt 2177161 agcaaaacca gagaaatata aagatagtac aggtgcttgg cattcaagcg ttgagatgga 2177221 cttacacatc aggatgatgt ccatgcaaaa gccacatcaa gcactggctg tcactggagc 2177281 gatatgtaca acaagagccc tttcagtgga aggtgcaatc cctgcaagaa tagcaaaaaa 2177341 ccactctaca aaggttcggc tagctcattc ttctggtatt attgaaacaa tggtggagcc 2177401 cactggtata aagatcgtcc gtaccgcacg acgtattatg gacggaacag tttatacgca 2177461 tggagactat caaatgatgt agatggactg tgcaaaaagc ctcccccctt tccatcgtta 2177521 atagatggat tgaatgcgcc ttcttgcaca gatccattgt aatcttgcat ggctttaaaa 2177581 aagcctctat attgtttttt atgaaatcgc caaggtcctt tcatgtatct gcctcaagca 2177641 tgacataatc attatagaga aaattgaata ctttttactg caaataaaaa gataccaaca 2177701 tcattggtat cttttagatt gagttcatct gcagcggttt cttttcctca ctgcttattt 2177761 gattacaaaa ttaccgtact cgtttgaacg aacatgaatc ggtccgttta gattatagtt 2177821 gttctccttg gcgatagagc gaagcacgtc cacacgggca actgattctc tccattcgtc 2177881 acgggtgtca tgattggccg gattcatcag atcgtcatag cgtacgtcca agaatttatt 2177941 caaccacttc ttctcgtcta ttccgtcttt aggtgatccg cccgcttttt tgttcgtacg 2178001 tttaatcaag gcataaaaag agtcagggtc atcaccatcg ccatgctgaa taaccgtatc 2178061 gtacatcaca gctcttgcca atgctgtttt tagtccggca ttatccgatc gtttcatggc 2178121 aggctgataa tacaaatggt catttacttt gtcttgagcg gcgcgaaatt ccttatcatt 2178181 tgcaagcgac ttccaggcag aagcgaatcc cttgagattg cttgtatcat cgctttcttc 2178241 cttggccaga cggcgcaatt caggcagata ctttttcagt ttgttattcg gaactgcctt 2178301 tgtgtatact tccactactt ccaatgcatc cccggtagcc gttgtaaagc ctgcccgtcc 2178361 gcatgtatag cctcgcccgt catccaatcg ctctacatat ccatattgga tctccgttgt 2178421 gccgttttca aagatacttg tcagctgttc cgcccggcgc ttttgatctt tattcagtcc 2178481 cgccgcaaaa accgtttcgc tcatcatcag ggtaaaaaac atggtgaaaa caagtaatga 2178541 gatcgctgct tttttccaaa aatctgcttt ttgcatactg attttcattt cacttcccct 2178601 ttctaaatat tgtaaataca gactcagtat acatgaagaa actgccctat tgttgaaaat 2178661 acatcaattt gtcaatattt tgaatctaaa gtaatatagc ttgaatctta ctctattcat 2178721 tgccaatcag ccttagcccc tctcactggg aaggtccctt gattttcata ctgcttcaac 2178781 tttcattaac aagatgccat aaggctttac tctattttat aatggaagtg atcatcgaaa 2178841 atcgttaggg aggtgatgta atggcaagca agatgagaat gccagattcc gcaacgtccc 2178901 atgcaaagcc tactattggg aaggcgatac tttgcatggg gtagactttc taaaagatcg 2178961 cccaagtaag cttttctgat atagtggctt tgcaccttat ttgacataaa aaaataagga 2179021 gctggcagaa atggcatatg taaaagcaac cgctatttta cctgaaaagc tgatatcgga 2179081 aattcaaaag tatgttcaag gaaaaacaat atatatccct aaacctgaat cctctcatca 2179141 aaaatggggt gcgtgttcag gaacaagaaa gctgatcgat gacagaaacg cttctattaa 2179201 aaaagcattt aaaaacggca aaaccattca tcaattatct gatgaatatc acctctctat 2179261 tgaaacaata aaaaaaattg tctactctaa ataaacaaaa cggaagcact gataaaaaat 2179321 aatcagtgct ttttatatgg cgagtttgtt tcttagttat ttcctgcata tgataccatt 2179381 ggccaattgt gtaaagttaa gggagatgag aagaaaggaa ggtcctacaa atgacgataa 2179441 acaatggaac gttgcaagta cccggcgcga acatccacta tcaggtgcgt ggctctggtc 2179501 caatcattct tttggtccac ggaggaggcg gtgatgccga caagttccat catgttgcca 2179561 atcatctggc taactggtac acggttgtta cttatgatcg ccgcggccat tcccgcagca 2179621 atctcgccaa tcagattgag ggttaccgtg tggaaacaca cagtgacgat gctcaccgtc 2179681 ttctagccaa aatcaccaat aagccggcct atgtatttgg aagcagctcc ggggctgtta 2179741 tcgggcttga tctgtgcata cgccatcccg aacaagtaca tgtcatgatc ccacacgaac 2179801 caatcttatt gcagcttctg catggaaatg agctgaaaca agccgagcaa ttcatggaag 2179861 accttaagaa aaatcatcga agtgaagtca ttaaattaat gtcaagatta gagacagacg 2179921 aacaatcaaa ggctgtcctg acaaagcggc ttctcggcaa ttcaacgtat ttcactgagt 2179981 atgaaattca aggaattctc agctatacat tagatttcga agcattaaaa actgtgttta 2180041 catcttcacc gatgaagata ctcccagctg gcggaagtgc ttctcgggag ctttttcctt 2180101 atcgttgcgc gaacgcccta gcggaacaat tggaaacaga atgggttgaa ttccccggaa 2180161 atcatacggg gtacacaatg taccataaag aattttctga gaggttacac gacatgttag 2180221 aaaaagaaaa gaaacatacg tgttaaggat tgattaaaat tttcaaaata ggacaggtga 2180281 aactaactat ggaattggag aagatttcac gaagcgtaaa aagaactttt cactaacgag 2180341 aacgcaatgt gagatgttta accaaagtga tattagggat ttcatcgaaa aataggtttg 2180401 tacattacgt tctcctattg attatttcct atcttaattc cgtattttat accattagat 2180461 acaactctaa agcggctcgt tattttgtcc tcaacaacaa ccagtgtcta acatcatgaa 2180521 tctcttttga aaatcaccac aaatgcaggt atggaagact tcatcgcagc aaaaaccata 2180581 ccaactattg ttgttggtat ggttcgtcct agataggccc ttaagaagag attctattgt 2180641 acggagtatt tagctaattg catttgtaac cgacagggcc gtctgaacct gtgtacacat 2180701 atgtgtcaga cacatatcca atattcacga caccccggga atctttccac tggatttggt 2180761 cccagatatt actcgttcca tacttccctg taacagtcgt tccataagcg taacaataat 2180821 aaggaacacg ggagccactc ggaatggaaa gcataatagg ataatttgta ccaggaccgc 2180881 tgcgcatatt gacaggcgca ccgctgcttg ttgagacagt aaagtactga acggcaagtg 2180941 cctgactgga aaaaatgaat aaagatgcaa tcatcacggt taacatactc agcattttca 2181001 gtttagtcaa tgtcatccct ctttcttcaa ttccttcatt ttaagaaacg atagaacata 2181061 ggctaccagc tgcatttagg aacaaccgga ccgtctgagc ctgtatacat atatgtatca 2181121 gagacaaatc caggaacgat ctccccgctg gcaagcgtcc gctctgtgta attccaaata 2181181 ttgctcgttc catactttcc agttacagtt gtaccggttt tgtagcaata gatcgggatg 2181241 cgggttccgc tcggaatggt cgttacaatt ccccaacttg tacctgggcc gctgcgcatg 2181301 ttgacaggag caccgctgct tgttgaaacc gtataatact gagccgcaag tgcatggcta 2181361 gaaaaaatga acacagatgc aatcatcacc gttagcatac ttagcctctt taacttattc 2181421 accttatacc ctccccttat aaatgccgta cgtttgactt tcttacatcc agttaaggat 2181481 ttactttcag ataccatgcc ccctcccctc ccatatattt atcaatgtac cataaactag 2181541 atctttcaaa agtggaatta ttcctatgtt ttcgacaatt aaggatacaa aataaatggt 2181601 agtcaggctt gatattgatg gtgtgttaca tttggctctt aatcatttgt ccagtcggta 2181661 atcacgattg acaatcagga aaaaggacat ggatcaagcg gcttcgtttc caccaattaa 2181721 ctcaatcagt gtactgcttc cttgtatcca cgcttcttct cgattcatag atactccacc 2181781 tttttcacca atcaaaaacg gacaccatac aaatcagcgt aaatgctgca agttcagtgt 2181841 ccgcaaccta ttatgacttt gctttctttt accagggcgt gtaaaaatga ttaggtacgt 2181901 tatcaaacgt tattctatga ttttgcgagt caaaaaatca taacatttta tatatttcaa 2181961 tcagattatg atctggatct ctgaagtgag caactcgggc actccattcc ttgcgatcat 2182021 gcggtttatt ctcacattta actccttttt cgtgtaaatc gtcatacgtt ttatcaacat 2182081 cttctacctt aaactgaagc aaaaattttg attgagcttc tccttccaag gacttttttt 2182141 cctctccaac gatttcagcc atcgtttctc gagataaaag ctctattttc gtttccccat 2182201 tatcaaagag tgcatattcc atttcattct ctaaccaact tattggaagt cctaatgaat 2182261 ctttataaaa ctcgacgctt ttcttaaaat cattcaccaa cagtctaatt tgtaacagct 2182321 tcatatcgag tgcctcctat aaaaccatac ttttactggt catccaattt aatgatacca 2182381 aagaaacctg acagcactat gtcaagtttc catacttcac ccttatttca gatttaagtg 2182441 cagtttagtc catgtcataa gaacgagcaa aaacagcgat tcttaaaaca aaaaatgata 2182501 ccgagtgtat tttctgtatg cttcaacttc atttcgggaa atgtaacgtt gataaaagga 2182561 ggttacatca atatggatca tcaaacattg gcagctcatg aggctgttga cttacatgaa 2182621 atcgtgaact ttaaaacact ttgtatagcg aaatcaaagt taatgcaagg gcttgtgttt 2182681 gaccaagaac tgaaggactt gatggaaaaa gatgtacagc aatccattca agaccttact 2182741 gaattacaag cggtttatga gcgtgcctca tttcaggccc ctgtccctca aagccgccca 2182801 acgccaatca tcaattgaaa gggaggtaag cctctttgaa taatgatcat ttagacccca 2182861 ttaattcgct gaatgtgcct gaactagcag acactacatt cgcgatggat tttcttatac 2182921 gagctaagga aggcgtaagg aatactgctg tagctttgac agaaaccgct tcaccagatg 2182981 taagagcact gcttcggaaa cagctgatgc aaggaattgc gatgcaccaa gagattacgg 2183041 aactgatgat cagcaaaaag tggttccatc catatgagct gagcgaacag tataagctgg 2183101 atcagctctc tgcaaaaaac acgatcatgg tcggcaatat gaacctcttt cctgatgaaa 2183161 caaatcgcaa agggatgttt gaccggacac ctgatgaaca ctaacactgg aggttttaca 2183221 gcatgaaggc agtaacgtat caaggcatta aaaatgttgt tgtcaaagat gtccccgatc 2183281 caaagattga aaaatccgat gacatgatta tcaaagtcac cagtacagcc atttgcggat 2183341 cagatttaca tttaatccat ggattcattc cgaatatgca agaagactat gtcatcggcc 2183401 atgaaccgat gggaatcgtc gaagaagttg gttctggggt gactaaacta aaaaagggag 2183461 atcgggtaat tattcccttt aatatagcat gcggggaatg ctttttttgt aaaaaccagc 2183521 tggaaagcca atgtgatcag tctaatgaca atggggaaat gggtgcttat ttcggctatt 2183581 cagggcaaac tggcggttat ccaggcgggc aagctgaata tttaagagtg ccgtttgcga 2183641 attttaccca ttttaaaatc cctgaatctt gtgaggaacc cgatgagaaa ttaagcgtga 2183701 ttgccgatgc catgaccacc ggcttttgga gtgtggataa tgccggcgta aaaaaaggcg 2183761 atacagttat cgttctcggc tgcggaccag tcggcctgtt tgctcaaaag ttttgttggc 2183821 taaaaggcgc aaaacgcgtc atagcagttg actatgtaaa ctatcgctta cagcatgcga 2183881 aacgtacaaa caaagtagaa atcgttaatt ttgaagacca tgagaataca gggaattatt 2183941 taaaggaaat cacgaaaggc ggagcggatg tagtcattga cgctgttggg atggatggta 2184001 aaatgagcga tctcgagttc cttgccagcg gcttaaagct tcatggcgga acgatgagtg 2184061 cattggtcat tgcttcccaa gctgttcgca aaggaggaac catacaaatt acaggtgtgt 2184121 atggaggcag atataacggt tttccgttag gagatattat gcagcgaaac gtcaatatac 2184181 gctctggaca ggctccagtg atccactata tgccgtacat gtttgaacta gtatcgacag 2184241 gcaaaattga tccgggagat gttgtcagcc atgtcctgcc gcttagtgaa gccaagcatg 2184301 gctatgacat ttttgattca aaaatggatg attgtatcaa agttgtgtta aagccttaaa 2184361 aaacggaggt tacagaaatg gaatacgcct tacacgaagt gcttgaggtt caggaaatga 2184421 ctgcatttaa gacactttgt ttgacgaaat ctaaaacaat gaaagcactg gtatctgatc 2184481 cgaagctgaa agaaatcatg cagcaagatg ttgatatcac cacacgccag ttgcaggaat 2184541 ttgcctctat tttatctaat gcaaagcaag aatgaggaga tgaataaatc atgaatccta 2184601 tcatagaata tctgactggc atgaatgttc taacagacca aatcattgct atggacttat 2184661 taatttcagc aaagaacgga gtcagaaatt atgcgatggc agccactgaa gccggaacgc 2184721 ctgaagtaaa agaggtcctt atccgccatt tggaagaagc actcgatatg cacgaacaac 2184781 tctcaagcta tatgatggaa aaaggctggt accatccttg gaaccctgac gaacaagtca 2184841 agctgaattt aaaaaatatt gatacagcca ttcaattgcc aaccctttaa catacaatga 2184901 ctgatttgct gaggaacagt attgattggc cacaactgtt cctcagcttc aaaatgagca 2184961 ctgtttgttc gggtcctatg accgtaaata gattaaccgc ttttctccat ctgatctccg 2185021 ataatgtttg caaattctcc aatccaaata aggaatcgta accacctctt tttatgcgat 2185081 ctcttgatgg agaaaacagg ccagaaacaa aatccttcgt ttttgacctg ccctcttcac 2185141 acgcaaagaa tgctaccttc tttgctccac tgatccgtga agactttccg ttttaggcct 2185201 gcttttgagc tttgcctcat tttcacgcaa tttcccatca taatctttaa tttttgtgtc 2185261 taatctctta attgtttcat caatttcttt ccgcttctct atcagccgct gtcgttcgtc 2185321 agccaggata ttttttcgag cttctaccgt acggtcacct tcggtaaata atgttgtata 2185381 ttcaattagc gcttctatcg atagtcccgc atttcgcatg catttaatga attcaatcca 2185441 tttgatatct tcttcatcat agtcgcgaat gccgctgtct tttcgtttta caggcgggat 2185501 taatcctaca cgttcgtaat atcggagtgt tgcggctgtc aggccaaact gctttgccac 2185561 ctgagcaata ttcatgatct tcacctctct atcctgtatg ttgtgaaggt aacacttaaa 2185621 gttaacttta agtcaagctc aaaacaagtg gttagctgct gaatctgggt ttatatattc 2185681 gggacttgcc ttaaagcaca ctttaaactc tatacttctc catgcactaa aaacagtgta 2185741 gttggaggga ttgctgaatg gcaaataaac acactgccgg aagagaacaa ttaggagaat 2185801 ttgcgccaaa gtttgctgaa cttcatgatg atgttctatt cggtgacatt tgggcaagag 2185861 aagaagaact ttcatcccgg gatcgcagca tgattacagt ttctgcatta attactgact 2185921 gtttctcagc ttataaatca ggttcatttt aaatggtttt tttaaaaaac ccttgcctta 2185981 aagcagactt taaggtttat cgttatgttg aagacaccat aaaacataaa taagtgcatg 2186041 tttttattta caacacttat gatgaagaaa ggataggttc gtatgtgtaa tcaacatcaa 2186101 acccgtgtat taagcgtgtc acatgcaaaa gccaaatttg aacaaacgac gattgagcga 2186161 agaggattac ggccgcacga tgtcttaatc gatattaaat tcagcggcat ttgccattca 2186221 gacattcata gcgcttttga tgaatggggc ggtggcatct tcccaatggt gcctggacat 2186281 gaaatagccg gtgttgtaac agccgttgga acaaaagtca ccaagttggc tgtcggggac 2186341 cgcgttggtg tcggctgttt tgttgactct tgcggagaat gcgaatactg tctcaacgca 2186401 gaggaacaat tctgcacgaa gggtgttgtt caaacgtata actcagtaga ctacgacgga 2186461 aaccccactt atggcgggta cagccaaaaa atcgttgtca ctgacagatt tgttgttcgc 2186521 ataccagatc gtttggaaat ggatgttgcc agtccgctgt tgtgtgcagg tatcacaacg 2186581 tattccccgc tgaaacactg gaatgttggc cctggtaaaa aggttgcgat tgtaggcgta 2186641 ggtggccttg gacatttggc aattcaattt gcacatgcga tgggtgcaga agtaaccgtc 2186701 ctgagccgtt ccatgaataa gaaagaggaa gctctggaac tcggtgcaaa tcattacttt 2186761 gcaacaagtg acccagccac attcactgca ttggccgggc gttttgacgt gatcttaaat 2186821 acggtatcgg caaatctcga tgtagatgcc tatttatcaa tgcttcgtat agacgggaca 2186881 cttgtaagcg ttggagctcc tgccaagccg gacacataca gtgtgttttc cctaatcatg 2186941 gggcgccgca gcattgcagg ttctctagtc ggcggaattc aagaaactca agagatgctg 2187001 gatttcgcag ctgagcatgg catcgaacct aaaatcgaag tcatcggagc tgaccaagtg 2187061 gacgaggcat acgaacgtat cctccgaagc gatgtccgtt atcgatttgt gattgatatt 2187121 tccacattgt aataggttag tccttatatg ggctgccgct tttattgaaa ctcacgaaaa 2187181 atgatctctt taagcaaata ttttgaaggc cggtcaatct tcctgttatt ctatgaatag 2187241 agagttatta ggagggtttt ttatgagcaa aaaaattgca gttcttgtta cagaccaatt 2187301 cgaagacatc gaatatacaa gtccggtaaa agcatacgaa gaagctggct acagtgttgt 2187361 ggctatcgat ttggaagccg gcaaagaagt taccggtaag catggcgaga aagtaaagat 2187421 tgacaaagcc atctctgatg tggatgcaag tgactttgat gcacttttaa ttcctggggg 2187481 attctctccg gatttgcttc gtgcagatga ccgtccgggt gaattcgcaa aagcatttgt 2187541 cgaaaacaaa aaacctgttt tcgcaatttg ccacggcccg caagtactga ttgatacgga 2187601 tcttctaaaa ggcaaagata tcacaggcta ccgcagcatc cgcaaagatt taatcaatgc 2187661 cggtgcaaac tacaaagatg cagaagtagt cgtcagccac aacattgtca caagcagaac 2187721 acctgatgat ttggaagcat ttaaccgcga atctttaaac ttgttaaaat aacaagaagg 2187781 cacagactgt tcgggtctgt gcctttttta aaattaagac tccttcgtta cattctgaaa 2187841 gacagcagtc gcgtcccaca cattcaagcc aaattggcct tctgaaaata cggaatcatg 2187901 tgcatcaatc acaagacgat catctaaata gattttaaag cgatcgccct cggcctctgt 2187961 tttcagatga tactttttat taacgtctat cggtgttttg tattcagcaa tgacagaagc 2188021 agcaccgttc tcaaatttaa agaatttcac taggtcatgc ttcgcatcca cattggcaag 2188081 gtaaccgttt ttggcatctt tgtcagagcg aaacattagt gctcctgccc ctcttccgtt 2188141 tccatcctta atggtgatat cagattcata agtgaagtct gacccggatg ctgaagacaa 2188201 gataaaggaa tcgccgtccg acctcccttg tttcccctca attgtgtctg cccacgtgcc 2188261 atttacagtc gtccagccag tcatattgga cataaaaggt gtcgttcccc ataccttttt 2188321 taaagggtgt atcgttaaag attttacctt tacaccgcca tttgcagcat ataattcaag 2188381 ccctttgctt gatcggtctg ggagaataat atccgttatg acctgctttc cgtcattccc 2188441 aaatacttca accgaggagc ggtcaacaaa aatgcgcaac ttaaccttcc catttaccgg 2188501 cttcaacggg gctgtttctt ttccggtgtt aaaggccgga ttaaaggtgt cgttgcctga 2188561 ctcgctccgg tcaacgaaca atttggcgtt ccttcggtca tagccgacct tcgtaaattg 2188621 attttcacct gttcggacct taaaaccaaa ttcagcagct gaaccagggc ttactttaaa 2188681 ttctgcattt atttcatagg catctccaga ttgccccgct aacacattat gacttgcagg 2188741 cgatatggtc agattcttcc acttcttaga ggttccgcga atggtttcca gctctttcac 2188801 cggtgtttgg accactctaa ccccttcggt aaacgctttc aattttaact ctcttggaat 2188861 ggacgttgca cttctccatg gggatgtcgg aacatcattc gcatattgcc aattgctcat 2188921 ccaccctaac catagccggc ggctgtctgt ggatggaata tcagaccagg atacagccgc 2188981 ataaaagtct ctgccgtaat ccgtccagag aactttgttt ggcgggtttt catttttaaa 2189041 atgagttcca tcaaagtccc ctacaaaata ttgcatgcct gatcctcccg agaccgctcc 2189101 gtttccgaca ctgacctgca tgacccattt cttttgattc ggattgccgt ctaccggaag 2189161 ctcaaataaa tccgggcatt cccatactcc cccgtggctt ccttgatcct gtccaaattc 2189221 acttgcatac gtccactgct tcagattttt tgatgtataa atgaggattc ggtcaccggc 2189281 cgcaagcacc atcacccact ttttttcttt ctcataccaa aagacttttg gatcgcgaaa 2189341 atctttttta cccgggtttg gaatgacagg gttgccagcg tacttcgtcc atgttcttcc 2189401 tttgtcgttg ctataggcaa tactttgcac ttgatggcct tcccgatcct gtgtataaat 2189461 ggccacaagc ggcttctctt tgcctgtttg aaaaccgctt gtgttatttt tatctacaac 2189521 tgcgcttcca gaaaagatcg tgcctttttc atccggatac agcgcaacag gaaggtgttc 2189581 ccatgtaacc aaatctttgc tgacggcatg cccccaatgc atgggccccc actgaagccc 2189641 gtatggatgg tattgataga acaagtgata ttccccagca taatatacca ttccgtttgg 2189701 gtcattcatc cagtttgcct ccggtgtgaa gtgatattga ggacggtaat cctcatcata 2189761 gtagcttgaa tcggctgcat ctgccgaaaa tgccatagtc aacagcaggg tgaacatgat 2189821 catgacttga atcagtctct ttttcatttg ttccttcgct cctctcttca tgtttgaaca 2189881 ctttcaaaag agactgctgc gcaagctggt ccgtttctgg caattctcct ctgtttcact 2189941 gttatccgaa tgatttatat atgaaaagac tgctgcagtt tctctctctt tccttcacac 2190001 accttatgct aagaatccag cccaataccc gagaatcccg atgacaaaga tgccgcaaat 2190061 aatgagaagt ggattcaccc ctttgcgaag catccatgcc accaataacg ttaatccgag 2190121 aggcagcgcc cccggcataa tgctatctag cacgttttgt accgtttgaa catctacttt 2190181 tccgctttca tccttaatcc tggatacaac gattggaatg ttgatggtgg tccatttgga 2190241 cacgagagcc cccataacaa ataacccgag aatcgaagcg ccctctgtaa gcttttgaat 2190301 gcgattcccc gctaaatcct gaagaatctc cattcctttc acatagccat actttaatcc 2190361 gtaatatttt gtgcttaatc ttatggcatt cagcaagaaa aagaatagca aaggaccggc 2190421 aatgtttcct cctaaagcaa gggaggctcc tagcgcagct aagacaggac gaatcgttcc 2190481 ccaaaaaatt ggatcgccta cgcccgctat tggtcccatc aaaccgattt tcattccgct 2190541 tatcgctttt ccgtcaattc ctttattgtt cgccatttct tcttccatgg ctgccgtcac 2190601 gccaaatata ggcgctgtca gccacggatg tgtattaaac cattccaaat gccgctgtaa 2190661 ggcttcgttt cttttcgctc cgggaccgta caattttttg atcgccggta tcatgacata 2190721 acaatatccc attgcctgca cacgttcgaa gttaaaggaa ccgagtaaaa aatttgaacg 2190781 aataaacatg ctgaaaattt ctttcttcgt taatcgtttt tctttctcca ttttttcttc 2190841 cccctcatcg tttaggcatc aagatcatca tcatcgtcat cataaacagc aacactgcca 2190901 ctgtctgatg cggccgcgac tgctccgtga gcgctttgtt tttgcatcac ctgctggtat 2190961 aaaagcgcca gacagagacc aagggctcca aatcccacta agttaaaatc ggtaaacgcc 2191021 gctaataaga aaccaatata gaaaaatggc tttaaataag gaatattcat catattgatc 2191081 accatggcat acccgacaac cacaataatg cctccgccta tttgcagtcc ttttgtaatg 2191141 acatcaggaa tatttcccag gaacgcctga acagcgctga cactaattaa agcaacaatc 2191201 aatgtaggaa tcatgacgcg caaagcttga aacaccatcg cggtaatatg cataatttca 2191261 attcctttta tatttcccgc ttttgcatat tgatcagcgc ggtggatgaa aaagacagtg 2191321 atcgtccgaa caaaaatcgt cagcgcctga cccgcagctg ctaaagcaac agcgacagca 2191381 atcccttcgc caattccttg atcagcggta ataactaaaa tggttgagat gacagaggcg 2191441 atcgctgtat caggtgccat ggcaagcccg acgttcatcc agccgagcgc catcagctcc 2191501 agtgtgcctc caagaataat tcccgttttt aagtccccga gcaccaagcc aaccaacgta 2191561 caggccacta gcggccggtg tgtctgccct tcatccaata cacttgcgat tccggtgatt 2191621 gctgcaatga ttaacaacaa aataatttgt aatgaagaca tattctcatc cccttgatta 2191681 ttttgttacg ttccgtaaaa tctgtacaaa atcctcactg gcatctgaag gcagctgcct 2191741 caattccagt ttcacgccct tgtcacttaa tgtttcaaat gcctttatat cttgttctgt 2191801 gacactgact gattttgtga tttgcctgcg atgattttca aaacgcattc ccccgacgtt 2191861 tacggttttg atcggtacac ctgcttctat aagagataca atatcggacg gattttcaaa 2191921 caagagcatt gccgttaccc cttcgtagcg cggactatga aatgcttttg ccattttaga 2191981 aaccgagacg gcactcgcct ttacatttga aggcgcaaca gaaaggatca gcgtttttct 2192041 catttcgtcc tgagcaatat cgtcggagac aacgatgatt cggtcggctg catggacttt 2192101 tatccacctt gtcaggattt ggccgtgaat aaagcggtca tcaattcttg ctaacacaat 2192161 gttcatcata attcatcctc tcttgtatct tgattggctg tttttacttt ttctaaatgt 2192221 tcactgcaca cttgaaagct ttgctgactc attgctttta agttgttcag caaatctttg 2192281 agagccagat gttctctcag gcttaatacc tccagcagaa tcggcaggtt tacgccggca 2192341 gccatatcca ttctttgatc ctcagcaata aaggaagctg ccgcgttata tggcgtccct 2192401 ccaaaaatat cgactaaaaa aagcacttca tgttcttccg ggatatcctt gagcgcctga 2192461 tgatattttt cttgcagcgt ttgtattcct tcccctttga aaaacggcac tgcaatcagg 2192521 ttattttctt caccgaatat catccctgaa gactctttta atgctatggg aaaatctcca 2192581 tgaccgctga taataactga aatcatatct attgctcctt tcctgttttg tacatccata 2192641 tataatgcaa ggatcgtgcc aacacagttg tgttaagcgt tttcattgtt atttcagcca 2192701 atagcaattt gttgttgaaa cacttaaaac gaaaaaaata aacctgtatt aaaatggtgt 2192761 tccatttaat acaggttcat atgaaaaaac tgtttttaaa acagctggcc atgcacttct 2192821 tcagcaaata tggcggctat aaataatttt tcatcatcac ttatgcgaag tccgagcttt 2192881 tcttcataag gggctaatgt tcgctctgtc acgtacacca tttccttcag ctgatcattg 2192941 atctcttctt cctctgagaa agcgatcgga ttctgcttaa ttaccctttc aaaggcgaaa 2193001 gccgtgtgca taatgacttt gatcaaaacc gcattattga aaatgacccc cagctcatcc 2193061 tgaacggttt gcagccactc caataacatg tcgatcacat ggtggggatt caagaagaca 2193121 aggtattttt tcaggctatc ctcgcaaagc tccctgacaa taatatttgc ttcgttcaat 2193181 ccattgctca aggagatgct tccttttgta atcgcctgtt gaatcagctt ctctccctcc 2193241 ccttcaatta acacttctaa agatacatgc ggagcattga ttttagggtc tttcgttccg 2193301 actgtcgcaa ggatttcata ctctttttcg atttctttta tgctgttggc cagcttaatc 2193361 gatgatacgg tcaatatgtg aatgggggta tcggaggcct tgtttacgat cgtggttaga 2193421 atgtcttcca gctttttggc cgttccgcta cccgtcgtgc agatggatac caatgccttc 2193481 tttttgccgg atgccgctgg ctgacgctcc cacaactcga taaaatcctt cgtgaccgat 2193541 tgatagatcg catgcaaatt taaattcaaa tagttgacct ttctgacagc atccagcacc 2193601 attgaagtcg taacattgct gatcgtttta atagaaatgc ctgtcttttc ctccagcctg 2193661 ctttccagca ttgcaagcga ccccatatct accagcatta aaacaccttc accttcatca 2193721 acctgtttca ttttttctgc tacgcattca agaatgtccg aaggtgaaac agtaagcggc 2193781 atgtcaactg ctgcaatcgg cgtactccct agcagttctg tcgcgacttc aaccattgaa 2193841 ctcgccgtgc tgtttccatg agctgccacg ataataccga ctcttttgtt ctcctttaac 2193901 gatttgatgg aatgaattaa catcgttaag tagatgactt ctatttcagg aatagccact 2193961 ttaaaatatt cctgaatttt atctttaaaa atcatcgcca cccgatattc tttcacatgg 2194021 gtatcacgaa tttcatctgt ctcctgtgta ttcaaaacat caatttgctt tcctcgcttt 2194081 aaaaatgcgt caatatgcat actcaagaaa taaataaact tacggtcaaa tgtgcaatcc 2194141 agctcatgtt cagctatttc ttttaactgt tttgtcattt gaatcacatc gtcttcaacg 2194201 aatgtcagca ggttgtcttt ttgaaaagct tgatgatgaa aaaaacttct gacatgcaaa 2194261 tggacatcag tcaagatgta ctggttaata tcctttttgg ataaaccttc tttcataagc 2194321 gttttcactt tttcctcaat caaatgatat aagttaaatg agaggtcttc gtcaattttt 2194381 gttgtttcat cttctacaat cggagagata atcgttgtaa tattgacata ttcagaaatg 2194441 gctttgcttc tttgcatgtt tttgctgctg gacatccatt cttgcttgat ttcatcaggc 2194501 agatcgcgaa cagtcagttc aataacttca tttctgtcaa ggttatgcaa aaatccgtgt 2194561 gcgcaaacta actgaacatt tgatttcagc tgtccgacat tcccaaattt cgcagagtga 2194621 ataagcgcat tatagacatc gatatgcaca ctcagattct tcttaattcg ctctgcttct 2194681 ttccctaata aaaacgtcgt cagatccact ctttcattaa gcgatcgttc ttcaagcgaa 2194741 ggaatatgaa tggtcattgg gattcttcgc aaaaacgttt tcaatagtgc agaactcgga 2194801 ttttctgtag tcgcacaaat aaacaatacg ttcgatgttc gtttatgttc agattctcca 2194861 agcctgttat aagaaccgct gtcaataaaa taaaacagca tttcttgtcc ctcgggaggg 2194921 agacggtgga tttcatccat aaaaagaatg cccccattgg cctgttcgac taaacccgcc 2194981 ttatcctcgg cagcacctgt aaatgaacct tttttgtgtc cgaataattg agaaagcaat 2195041 aattgagggt tgttgtagta gtctgcacag ttaaatgtaa taaatggtgc gccggccttc 2195101 aatatgtcag agtaaatggc aaactggtaa attcggttcg caaaaaggga tttaccggaa 2195161 ccagtcggcc ctaggaggag catatgcaga ccgttcggcg gataaaagac agctgctttt 2195221 gcctgggaga tcgctttctt caaactccct tttgccccta tcataagctc taggggattc 2195281 gtggaaatgt gttgatgatt ttgctttgaa tttccggaaa acgcctgaag gtctttcact 2195341 tccatcatct ctgtatccca tttcttgttg aataattttt ctgctatctc gactgggatg 2195401 tatcttacag gaaatgtttt aattttgatg acctttttgg accggacgag attgttcaat 2195461 tcaaagctga cattggaccg ctccattttc agctgctcgg caatctcctt tgctgaattc 2195521 ccttgtattt ttaaaagatg atctaaggtt gaatcatgaa aattatgctt gagctgatgg 2195581 tatattttat ctattcttct cacgtctatc atcctttgtc cttattagat aagccattaa 2195641 caagaatatt tcgaaacttt atagtccgcg ttgagattta cacgtttaaa aaggtctcta 2195701 tagcagattg acaaagctgg cttttatgcg tatatgttta catgttgaat catttgcacc 2195761 tcatattagt atgatagatg ctcagttctg gagggccagt ccccttcaaa agtaataatc 2195821 agtaaacagt ttatcattct cggggaatgt aatgatgtca aaataatcaa tgacaaaaaa 2195881 tgaatcttat agatcatgac aaattaccca aatataaccc cttaagttcg ttcacaacta 2195941 aaaagacgga cactctatgt gaccgccaca gtattacaat ttgcaaaact tcgtcatttt 2196001 tgcaatccac attggaggtt aaggaatctg taagcttaaa aactttatct ccgatcctat 2196061 cgatttgatc cccctgccgg cctcaatcat agtgggtatg caattataca aatcgttacc 2196121 gattaaaact agcctgtcag attgtccaaa tgactttcct gttttactct gctattcagg 2196181 tagaatcacg agtgaaaaat agagccacaa gacatgtaac agcacttaaa atagttttaa 2196241 aatttaaaaa taaaagtatc tattctttta aatgttataa tatccgataa aactttactc 2196301 atctttttat tactggagga aaataaaatt gataggcaat tctagcaaag acaattttgg 2196361 ccagcaacag aaattgtcta gaggccttaa aaacaggcat atacaattaa tggcgattgg 2196421 aggtgcaatc ggtacaggtt tatttttagg ttcaggtaaa tccatccatt ttgcaggacc 2196481 atccatttta tttgcttact tgatcaccgg cgtattttgc tttttcatta tgcgttcgct 2196541 cggagaactg ctcttatcaa atgcgggata ccactctttt gttgattttg taagggacta 2196601 tttaggaaac atggcagcat ttatcactgg gtggacctac tggttctgtt ggatttccct 2196661 cgcgatggct gatttaacgg cggtcggcat ttatacgcaa tattggcttc ccgatgtgcc 2196721 tcaatggctg ccgggtcttc ttgcgcttat tatcctgctg atcatgaacc ttgccaccgt 2196781 taaacttttc ggagaattag aattttggtt tgcattgatc aaagtcattg ccatactggc 2196841 tctgatcgta actggtattc tcctgattgc gaaaggtttt tccgcagctt ccggccctgc 2196901 cagcctcaac aacctttgga gccacggcgg catgttccca aatggatggc atgggtttat 2196961 cctatctttc caaatggtcg tcttcgcttt cgtgggtatt gaacttgttg gactgacagc 2197021 aggtgaaaca gaaaatcccc aaaaagtgat ccctaaagcc atcaatcaaa ttcctgtccg 2197081 gattttactt ttttatgttg gcgcactttt cgtgattatg tgtatctatc cttggaatgt 2197141 gttgaatcca aacgaaagcc catttgttca ggtcttctct gcagtaggca tcgttgtggc 2197201 tgccagtttg atcaattttg ttgtattaac atcagccgca tcagctgcaa atagcgcttt 2197261 attcagcaca agccgaatgg tctattcact tgcaaaggat catcacgcac ctggactatt 2197321 aaagaaatta acttcttcta acgtgccaag caatgcgctg ttcttttcat ccatcgccat 2197381 tctgattggc gttagtctga attatttaat gcccgagcaa gtcttcacgc tgattacaag 2197441 tgtttcaaca atatgcttca tttttatttg gggcatcacg gtgatttgcc atttgaaata 2197501 tcgaaaaaca aggcagcatg aagcgaaagc aaacaaattt aaaatgcctt tttacccatt 2197561 atccaactat ttaacacttg catttctcgc gttcattctt gtcatattgg cactggcgaa 2197621 tgatacacgt attgctttgt ttgtcacccc ggtctggttt gttttattga ttattttgta 2197681 taaggtgcaa acccgcagag gacataaggt gaaataaaaa aaagacaagg gatactcact 2197741 cccttgtctt tttatatgtg tcaaacacta aattaaactt tggtttcaaa tttcattcac 2197801 ttcatttaag tgttaactca aaccagtttt gatgccgaaa cctactaata ttattccggt 2197861 aattttttga aacactttct ggaacttcga gtttttcatc catttttttg cgtaatcaat 2197921 aatataaaca agaaacagga accacaacac cgctaataag gttaggattg aagctaaaat 2197981 gatgagctgc tggtttatat ttccgttcaa attgataaat tggggcatga ttgtaacata 2198041 caccaaaaca gttttaggat tgagaatgtt actgagtgat ccctgcataa aggaagtttt 2198101 ataataacgt ttcggagaac ttgccatatt ttttgcttgg gattgcatgt catctaacga 2198161 aaacatactt ttagcaaaaa aactttttac acctaaataa attaagtatg ccgctcccaa 2198221 atatttgatc gttgtgaaaa gaatcactga ctttgcgatt accactgata atcctaaaat 2198281 ggcaatcacc gtccaaaagg aaagtcctgt cgccaatccg agaatgttat aacggccggc 2198341 tttcggacca tacctaagcg tatttttcat cacaagcatc gtatctgccc ccggtatgat 2198401 aaccatcatg gcagcgatcg gtatgtatgc gagtaagctg tgcattgttc tctccccctt 2198461 taaaaatccc ctcaatcata tagtgactac aaaagtaact acttataaaa gtgtatcaat 2198521 gcgtttggaa taaatcaata tgatttgtta aaatagcgat tactaaggca gcgattgctc 2198581 tttatattgg aggatatatg aaagaaaata tgttagacat tttaaaaaac ctcaatttta 2198641 cagaatatga atcgaaagcg tatttagcat tattgcaaga atcaccttta acaggctatg 2198701 ccgttgccaa aaaatccgga gtgccccgtt ctaaaattta tgaagtattg gaaagtcttg 2198761 tcataagggg agatgttttt gtcagtcatg gaaatacgcc tcagtatgtt ccagtccccg 2198821 caaaagaact gattaaaaac cgccggctca aagcggaaga gcattttgat caggctgaga 2198881 aatattttga aaagttcgag cagaccgcaa atgaccggga aaacatctgg aatatcaccg 2198941 gccgcagtga aattcttgaa aaggtgaagg cttgtatctt atctgccaaa aaaagaatcc 2199001 tcttagaaat atggaaagag gattttaagg agatagaagc agagctcaaa caggcggcag 2199061 aacaaggcgt tattgtcacc attattgcgt acggagacat cgtatctgat tttgccaatg 2199121 tttaccttca tgatatgagc agtgaaatta cagaagagta tgacggacgg tggcttgtct 2199181 atagcggaga tgattcagaa gtagtagcgg gcattgtctc acttggcaac gacagccgtg 2199241 ctgcatggac gatgcatgta gggttagtca tgcctattac tgaagtgatc attcatgatc 2199301 tgtacctcat ggaaattctg aaaaagcata gagagctttt agaagagagc ttcgggaaaa 2199361 atctcatcca gttgcgccgt aaattttcta ttcactcaga tttcaaaaaa cattatttgg 2199421 aataatgttt gtcatctctt accccaaaaa caaggcttgt acaaaacaag ccttgttttt 2199481 ttatgcataa accccccatg ctgatttact tctctctttt aaaaaatgtg attctgcgca 2199541 aactattttt cagcctgccg cgtctatcct aggtaacagc ctacgatata cgtatattca 2199601 aaaaggagcc ctttattgca atgaagaaaa aacaaacaac aaaagcgttg cttgtcacat 2199661 gcataactga ccataagcaa gatttctaca ggttggcttt cagttatgtg aaaaatcaag 2199721 atgacgcatt agatattgtt caggaatcta taaaaaaagc gctgagctca gttgaaacgg 2199781 tcaggaaccc tgagacgata aaaagctggt tttataaaat tttagtacgg acagccattg 2199841 actttttgcg caaacaaaaa aagataagag tgatggacga cgaaacgata gaatttttaa 2199901 gcaaaggaaa ggaagaccat tacaaggata ctgatctcca tgaagcgctt gacgaattgc 2199961 cgtaccgcta taaaaccatt attattttac gtttttttga agacctcaaa ttagaagaaa 2200021 ttgcggaaat tacaggagaa aacacgaata ccgtcaaaac gcgcctatac agagcattga 2200081 agctgatgcg cattcagttg acgaaggagg atctttctta atggataaga gattacagca 2200141 attaagagaa gaatataaaa atgttcagat tcctaaagaa ttggatatca ttgttgaaaa 2200201 agcccttcag caagaaccaa aaaagaaaag aatcgttatg tggccgacat cagcagcaat 2200261 cgctgcagct attttattca ctgcgcttgt taatatcaac ccggacgccg ctcaggctat 2200321 gtcaaagatc cctgtcatcg gcaaaatcgt caaagcgatc acctttattg aaatcaaaga 2200381 ggaaaaagac caatcaagca ttgatgtcaa aacacctgct ttgtccgggc tttctaataa 2200441 agagcttgaa aacagcatta acgagaaata cttgaaagaa agccagcagc tgtataaaga 2200501 gtttatacag tccacatcca aaaacaaaaa agggcatctc agcatctaca gtgattacga 2200561 gacggtcaca gacacgccag atttactctc tatccggcgc aatattgaaa caacacaagc 2200621 atcttcctac acacaaagcc gttatattac aattgacaaa aagaatgata ttttacttac 2200681 attaaaaagc ttattcaaag atgagcgcta tatcaaagtc atcagtcaaa acatcaaaga 2200741 acaaatgaaa cagcaaatga aggaagatcc aaataaaata tattggctca ctgacgaaga 2200801 tgcagaaccg ttcaaaacga ttcttcctga tcagacgttt tacattactg aagaccataa 2200861 acttgtgatc tcatttgacg aatatgaagt cgcccccggc tatatgggcg ttacagagtt 2200921 tacaattcca accggcgtca tttcaaactt gctcgtggga gaacgttata ttcgataaaa 2200981 taaaaacatc catctaagat tatggatgtt ttctctcttc tctattcgag gtcgtaaccc 2201041 cgctatcaaa aacaacgaga atatttgcat actattggag gaatacccat gtatcacaag 2201101 acacagcatc atcgatacat tcctggactt gatggccttc gggctttcgc cgtcctgtca 2201161 gttatcactt atcacctaaa tttcaattgg gctaacggtg gttttatcgg ggttgatatc 2201221 ttttttgttt tatccggata tttgattaca tctattctat taccggcata tggaaatgat 2201281 atcaatcttg attttcggga tttttgggtg cgccgcattc ggcggcttct cccggcagcg 2201341 taccttatga tcttttccac tgttgtgtgg gtcgtattgt ttgatcgaga actattgcac 2201401 actgtacgtg gagatgcgat ctcttctctc ttttatatga gcaattggtg gtttattttt 2201461 cacaagctat catattttga tagtttcggt tccccatcac ctctaaaaaa cctttggtcg 2201521 ctggcgattg aagaacaatt ttatatcata tggccgatgt ttttagttgt tggaatgtac 2201581 ataatgaaaa gccgcgccag attggctgcg gtgatatcat tgcttgtgct ttgttcagcc 2201641 gtgatgatga gcgtactgta tgaacctggc ggagatccga gccgcgttta ctatggcaca 2201701 gacactcgtt cgtttgaact tctcatcgga tgtgccttgg ctttggtatg gccgatgaaa 2201761 aggctgtctt ccaacaggct gccaagcaaa ctgaagcaca ctttgcacgc cactgaattt 2201821 ttggcatttt gtattttagt gttgtgtgtc tatttcacag atgaatacga gccttttctt 2201881 tacagaggcg gaatgctatt cattagcgtg actgccgcaa tccttattgc atgtgtttgc 2201941 catccgagca gctttttagg caatctgctt tcatggaggc cgcttcggtg gcttggaacg 2202001 aggtcttacg gaatttatct ttggcactac cctgttattg tgttaagcac gccagttcaa 2202061 gaaatcggaa accctgtttt ttggcatatc gtgctaaagg tcattgtgac atgtatactt 2202121 gccgagctct cctaccattt tattgagaag ccgatacgga cacagggatt taggtcattt 2202181 tcccgccgtg tttttataca tagaatcaag gaatggaaaa cgacatctgt catcagcaaa 2202241 atgtcaattg gtttcattat tttcgctata cttatttttg caggcgggct gtcagggcta 2202301 gccggcgagc aaaagcaccc taccaaatgg acctatagct cacaagaaac aaatgctgac 2202361 accagccagg cttctgggga taaaaagaac gctgcagcag ataaaaaaca caatcctgaa 2202421 caaaagacaa cagattccaa tcagggtcaa aaggaaaaca aagatagtgg gcaagagact 2202481 cataaaaaga aagacacgca atcccaacag ttgaaaaaac cagcagacac tgcgaaagaa 2202541 gttttagcta taggagattc cgtcatgctt gatatttctt cacacctgcg tcagtcattt 2202601 tcaaatgtga cgattgatgg aaaggtaggg agacaaatgt ctcaagcttt ggaactcgca 2202661 agggaataca agtcttttaa tcagccgaac aaggctgtca tcattgagct tggaaccaat 2202721 ggctatttta caaacagcca aatcgaacaa ctgcttcaat ctttctcaaa agctcatatt 2202781 tatcttgtca atacacgggt tccccgccaa tgggaaagca aggtaaatga atctttgcag 2202841 caacaggccc acgcacatca aaatgttacg ttagttgact ggcatacaga agctcttcag 2202901 catccggaat attttacccc tgatggtgtt cacttggttc ctaaaggggc aaaaactttg 2202961 actgctctta ttgttcaggc gatgaaatcg taaaaaagag atcctataca gatcactttt 2203021 ttactttagt ttctgatcgt tgattatgtc ttctttcagc aaggcagccc ttatgtttac 2203081 atgccgttta cgtaagggta agccaaaatt gaatggaggg atgataatga aaggaaatga 2203141 agaacatgac atccaaaaag agttgaaacg atatgagctt tttttcaaaa aacgatataa 2203201 ggttctttat acagtaaacg attttatcat cggtgctatg tttctcgttg gaagtttttt 2203261 ctttttttat gaccggttaa tgtcggcagg gatatggctg tttgcgatcg gaagtttgct 2203321 gctgttaatc aggccgacca ttcggctgat tcatgacttt cattaccgta agcatgtgga 2203381 acagcaattc aagcatcaat cttcaacaga tgactgatct taaggaataa gaaagaacaa 2203441 aatgccaaaa gcctgagtcg aaaatcaaaa acaagacttt cagactattt atttttaaaa 2203501 acaaggtaaa aagaactaaa cttttgcctc tgcatgccga tatgaataat aaggccggcg 2203561 cgatactccc tataacatcc ttttcagtag atttcattat cgtgccggtt ttctcatatg 2203621 caaagcaatc ccgccaatca gattggcggg attttatatt ttacattcct gtccaaacgt 2203681 ctttcacata acgtctttga tcttgcagct tttgcagcca tacagctgat tcttcctgac 2203741 ttgctgcttt ttcagcttca tatgccaatc gcaaagttct ctctacatca ggagccattt 2203801 gcgatccatc accgcatacg taaatatgag cccctttttc aatgagtgtc atcaatttct 2203861 gcgtatcttg cttgagcaag tgctggacat atccttttgg ttcgttttcg acgcgcgagt 2203921 agcatcggcg gattgtgacc aaaccgtcct gttccgcttg atccagctct tctctgtaaa 2203981 ggtcgtcatg gtccgggcgg cggcagccga agtataaaag tgcttcacca agggtgcttc 2204041 cttccttctt caaaaccgat cttgcctgaa taaagcctct gaatggcgca attcctgtgc 2204101 ccggcccgac cataatcata ggcgtttcag gatcattcgg catctgaaat ccggactgcg 2204161 gcgtacgaat gaagcaagct gctgcatcac ctgtattcaa ttctgctaaa taattagagg 2204221 cgacaccccg gtattcacct cggccgctcc atgctgaggc tttcacaact cctaccgtca 2204281 tgctcacgat atttgcatga actttcggtg agcttgaaat ggaatagtat ctcggtttta 2204341 gtgatggcaa aagtgctaaa aaccgttcaa acggcatttc gcaagcagga taatcctcta 2204401 aaaaatcaag catggtaaga cgttttgcaa gtacctgctc tttgtaaatg ccatcatctg 2204461 aaacgagctg ttccagctct ttttgatgcg gcggacaaac tgtataagag gccagctccc 2204521 gaagctgaag ccttgatgcc ggttcctgca gctctacata ggacgacaat aaatccacta 2204581 ctttgattgg ccgatccatc ggcagatgag ccatatgagc gcttccgctt acttttatca 2204641 catgattgga ctgcaaaccg aatcggctga gaacccgctg aacaagctcc ctgctgttct 2204701 ttggcaggat tccgatatga tcgccttctt tatatgtttt accagccgga atttccaatt 2204761 caatatggcg ggttgaacgc gtgctggcag ctgtctggag ttctcgattc tctaacacaa 2204821 tcccttcaaa cgcgccatat gctttagcaa ccggcgtttc cgtcgcttca ctgagaaaag 2204881 taatcgataa tgaaggcctg tcttctttct gggctatttc gttaatatca aatgcgtcca 2204941 tcgtttcctt ccagaagcgg ttttcccaag actcgcggtg gctttcaaaa tcatcggcgg 2205001 cgtcaccttc cccaatcgct gttaaacgcg atgccccctt tgctttcatc atgtcatcaa 2205061 tcaggcgggg aatccgctga tacgtgctgg cccagctccg gtttccgcag ccgaataccg 2205121 cataggaaac acctttcaat tggccttcct caagctcttt cagccactct acaaatccgg 2205181 cagcattatc aggcggcgcc ccattataag aagccgttac aatgacgact gccccttctt 2205241 cagggagctt gccgatataa tcatcaagcg gagccgtttc agctgtaaag cccatctggc 2205301 ggccttgagc agccagttca ccggctattc cctcagctgt cccaagattt gaaccaaaaa 2205361 gaacaagtaa aggtgtgccg tgtttaggtt tggtttcttt tggctttgtt tctgctttga 2205421 tgtctgcctg ttcttttctc tgtacattga ttgccgctgt ttttcgcggt ttcacagtaa 2205481 ttttaaaatc atccggcttg atcgttaatg cttctttgat ttttagttcg tagccagtat 2205541 ggtttatcaa ttcaaaatgc tttaatacaa gaccgagaac cattgtcgct tcttgaagag 2205601 caaactgcat gccaatacaa gcgcgctgtc cgtttccaaa cggcttatac gcatggtgag 2205661 ggatacttga aggatcctca aaccgttccg gacggaaatc ttccgcatcc ggtccccaag 2205721 cgttttgatc ccggtgcagt tttggaatta aaacagtgac tggctgccct ttgctgatcg 2205781 gatattcccc gcctagaaca gtatcctcct tcgcatatag agaaaaagcc ggagctgttg 2205841 gatacagtct gagggtttca tttaaaacca tccgaatgta tttgagctgc tggatttgtt 2205901 tatattcagg cgtgtcatcc gttaacacgc gatccgcttc ctcctgagct tttttcagtt 2205961 tttccggatg tgtaagcaga caataaatcg caaaggatag caacccgctt gttgtctcat 2206021 gtccagcaat taaaaatgtg atgatttggt atcgaatgtt ttcgtcatcc agcgtttcac 2206081 ccgttactgg atctttggca taaagcatga gagacaagag atccttaatg ttttcatccg 2206141 gattcgcctt tcgctccgct atcattctat caaccaggga gttcatgact tctatatcct 2206201 tttggaactg cagcttcgtt ttcaccatca ttttatcttg caggcccagt cttttcgatt 2206261 gattcatcgc ctcttttaag gcacggagca tactggtgat aaacggatgc tgtgaatcac 2206321 ggtaaaagct gttgaatcga tagttaaacc cgcataaccc aatcgtatca agcgtcagac 2206381 gtgtcatatc gtccgctaca tcaatttctt cattagggtt taaccggctc cacttttgaa 2206441 tcagctgggt tgcgatatcc agcatcatag aatgatagcc tttcatcgct ttttgactaa 2206501 aactcggcag caaaatgcgg tgggcttttt gccagttcgg ttcgtgcgtc cagcttgtaa 2206561 ataagccatc tcccccgaac tcacgcacct tttgcaagcc tttgccaagg ttcttgtcaa 2206621 agcgtttttc atcacacact tcagccacaa gattgtggcc ggacacaaaa acactggata 2206681 ctcccggaaa atcaaaacgg aaaatcggtc ccaattcatc agctatccgc cataaggatt 2206741 gagaaagctg ttctttttcc agatgcggaa gattttttaa aggtccgtat gttttgggct 2206801 gaggtattgc gcttgcctgt ttcattaaca tctccctttc ctatttttgt gatgaatgaa 2206861 gcttaatggc gtcccagcag cattgttcca attcagtaat taaatcagtg tccatctcta 2206921 tatcacctgt ttgaacgagc tgatatatct tgagaaacgc ccctaataca atcgcaatta 2206981 acacattaga gggcaggctg cgaatcacgc cttccgcttt tcccttatta aaatagtcat 2207041 caagcatttg agtcagattt tctatcattt ttttgcttgt atgatttaag taatgagcgt 2207101 cttttttggt ttcaagaaaa aaaagcgcat agtcgctctc tttcgtaaac tgaacgagac 2207161 agcaaaatac gtggtgaaag ccttctctga caggcaattc tgaaacgtct tgcttcagtt 2207221 tttccgtaaa tcgctggatg ctttcttgaa acagtacgtt aacgagtgtt tctttgctgt 2207281 caaaataacg atagatcgtt cctgtcccta catgagcacg ttcagctatc ataggaatag 2207341 tggtagcgtc aaaacccctt tccgtaaaaa gtgagactga cgctttcata atcatgtcgt 2207401 atttactgct ggatgcggat atcatgtaat ctgacaacct ccgattcgtt tacggaatga 2207461 atattcattc cttttgttca caaagaatgt ctgccctgtc tgatatcacc tctttgttct 2207521 ttcttctgtt ataagtttat atgaaaaaaa ctttttttaa tataaagtat atgcaaaaaa 2207581 taaaaaatta agaaaatata cccaaatcct aatacgagga tcttggatat atttcccgag 2207641 aaatttttta tttaacagcc acaatacata gacaggaagc acgcctgata acagaaagat 2207701 ccctgaaatg ctggtctttc agcagttgaa tatacgtttt ctctttttca ccggtatttg 2207761 tgtcaatact gatataaaac cggccgtcaa tttgaagcac cctgtaaatt tctcttaatg 2207821 caagcctaat atcggtgcag ctttgaaccg tatgtaaaga aaagacttta ttaaaggtac 2207881 ggtcatcaaa gggaatgtcc tctggatagc catgaaaaac ctccccgttc cccatgttct 2207941 ttcgattcgc acgtgatatc tgtcttacct ttcgttttga aggatcaatg ctttttaggc 2208001 tacccttttt tagtttcttg gttatgcttt taaagacagt gccgtttcca attccaattt 2208061 ctaaaattct gtcattttct tgtatatcta tagagtcaat catcatatgc tcaattgttt 2208121 tggttagctt atatttccga gaaaataatt tccaaaaatc cgatcgttta tagagtctat 2208181 tttctagcat tttaaacacc tgcttttggt ttcctatgtt tatttattat cttaaaaaaa 2208241 taaacatcat cttcatttct aaaagtgaag gaaggtacca actagacggc aatgtattga 2208301 aaaatgtttc aatagaacta aactttttca tttttttccg aaaaaaaagc agaaaacata 2208361 atgttttctg ccctctttct aatgccaatg ataagggaat acatacagcc tttgctgctg 2208421 cattgccatc agcctctgct gtcggaatgg atttccataa ccatgtttga aggaatgcgg 2208481 catggacgca taaccatggc caatcgacgg cagtcttttt tgataatcgt tcatcatgcc 2208541 atcacctgcc tcacaataac gttgatttac tatatgcagg cgcgcatttt cttgacagct 2208601 atttcgctaa acttggtcct tctccattgt ataatgcatc aatagttcca ttctaagcat 2208661 atgccattcc cccttcagtt tttttcgttg cttttagcgc cagtttgtta aataaagatg 2208721 ctttaactga gactctttca tttcatcata aatttgttca atctgctgtt ctcgttcgaa 2208781 ttcttccagg cttttaaacc gttttttaat cgttaacgtt aaaaagaata ggttaatcgt 2208841 catatcgctc accccctttc aaagtccgca tcaagcgaaa taacccgcgg cacaaccctt 2208901 ctgccgcggg caaataaaaa ccgcagacaa aagaagacac caatgcctct actgcctgcg 2208961 gggagttgcg tatgtccgac tattccgaat ttaatgcgtg cgataagcat cggttaagga 2209021 aggacacgaa ctcttccaca ggctgaataa accatgaact tttacatgtg tatcacgtac 2209081 aggttgacgt cgttgtctca ttgtcatttt ggttcagcct cctttgcttt tttcttactt 2209141 tgtaagtata tccaccaaat tccattttgt aaacatcttt ttctaaaaat ggacggaaat 2209201 tgtgcaaatc atcgaatgga tttgcccgtt ggtcatgaca cctgcttcat ttcttttctg 2209261 gagcggtctt tcttatgata tgcaataaaa taaatgagac cgacaaatac agctccgccg 2209321 atgacattac cgataaaagc cggaatgatg tttccgatga actgccccca cgtgaatgag 2209381 cctgcaaaaa tggcagcagg aatcacaaac atgttggcga caacgtgctg aaatccgata 2209441 gccacaaaag ccatgattgg gaaccagatg ccaaggattt ttcctgctgc gtcttgggcg 2209501 ccgaaagaaa gccacactgc aagacataca agccagttac agccgatggc ggaaatgaga 2209561 accttgccaa agctcatatc aagctttcct tgggcaacgg caatcgtttt ttctaaataa 2209621 ggacctgttt cagtcaatcc aaccaaatgc ccgaaaaagt aagcaacaaa caatgcgccg 2209681 attaagttca taattgtgac gattccccag ttaatcgcta actcttttac tgatattttt 2209741 ctcgaaaata acgccatcgc aactgacatc atattgcctg tgatcagttc agcgccagcg 2209801 agaacgacaa ggatcaggcc gactggaaat actgctgcac caatcaaact ggacaggctc 2209861 ccccattctt tcggaagatc gccaattacc ctgatatcaa gcaaataccc aagcgcgata 2209921 aatgcaccgc ctaaaaaccc cagcacaagc agtgacggca gcgggagctt tatttttttc 2209981 atccctgctt caattgctgc ttccgctatt tcatccggtt ttcgaaaagc cataataaaa 2210041 cgcctccatt acttcttctt ttctcacagt tatgcaagaa aggcaataaa aaaggcagca 2210101 ctcaaataac ctgtgtcaaa ccaggcgttt gaatgctgcc taacttgtat gcatacccat 2210161 acaacaatat caagcagtat ataagatatt gaaagagaat atatacagtt cgtgcataca 2210221 ttccattgct ttagccttct ataactgtag caacatcata tcaaatgtga caaatttgtg 2210281 tcaatgacaa atatactagc tttgcagagc ttctttttgc tcatctattt ttcggtcaaa 2210341 aacaaataca gatacagcga tgttttcctc aattttaata tcagaaaaca aatggactag 2210401 cttagctccc ataagttcct ccattccttc cggtgtttgt ttggaataaa ggtcttgaat 2210461 taggcttgtc cgggccgcat gtaccatctc tcttccttca ggcgtgcggg caataaactg 2210521 ctcgcttgca ctcagatttc cgtatagtgt tgaaactgcc atgttttcta caaatacagt 2210581 atgaattctc tcaggccctt ttccgaacaa ttctttgcga agttttcgaa taatatcatt 2210641 gaattcatga atttttttag acatgctgat taccccttcc gatattgcct tataaaggct 2210701 tttcccggtt cccctcagga catttcactt ggttaaaatt ttcctgccat attgtattat 2210761 aataaatatc acattataat aaaagcagtg ttgatggatt tgtaatagga tcttgttatg 2210821 agtctatcgt tttataaaaa tcaaggattg gtctgttagt aagacttgct agtgaactat 2210881 tccgccatgt gtgtttacac cttcttagaa ttaagggcag gtgtatctat acatggcttt 2210941 ttttgacttc ttgaaagaaa gatggagggg aatatgaata tgatggacgt taagtcgatc 2211001 agtgtccgtg tagacggaac agaaattcaa gcacgagcag gggccacaat tttagatatt 2211061 ttaaatgaaa acggaattga gtacccgcag atttgccacg taccagaggt tgacccgatt 2211121 caaacttgtg atacttgcat agtagaggca aacggcaagc tggttcgttc atgcgcgacg 2211181 gttgcagaaa acgggatgtc tattgatctt tcaggaaatc gagtgaaaga agcgcaaacc 2211241 gaagcgatgg accgccttct tgaaaatcat ttgctgtatt gtacagtttg cgataacaac 2211301 aatggaaact gtacgctgca taatacagcg gaaatgatgg ggatcgagca tcaaaaatac 2211361 ccatacacgc caaaagaaga tccttcttgc gcggttgata tgtctcatcc tttttaccgc 2211421 tatgatccaa accaatgtat tgcctgcggc cagtgtgttg aggtctgtca aaaccttcag 2211481 gtaaatgaaa cactctcaat cgactgggaa cgcgaacgcc ctcgcgtcat ttgggatgag 2211541 ggagttccga tcaatgaatc ttcctgtgtc agctgcggtc agtgtgtaac agtatgtcca 2211601 tgtaatgcac tgatggaaaa atcaatgctc gggcaggctg gttttatgac aggcattaaa 2211661 gaggacgtca tggaaccgat gattgatctc gtgaaaaatg ttgaaccggg gtatggcagc 2211721 atttttgcca tttctgaagt cgaagcggca atgcgtgaaa cgagaacgaa aaaaacgaaa 2211781 actgtatgta cgttctgcgg tgtcggatgt tcatttgaag tatggacaaa aggacgggat 2211841 attttaaaga tccagcctgt ttctgatgct ccggttaacg caatttccac atgtgtcaaa 2211901 gggaaattcg gctgggattt tgtcaattca aaagagcgga tcacaaagcc tttaatccgt 2211961 aaaaacggag cctttgtgga atcttcttgg gaagaagccc tcgatcttgt cgcaagcaga 2212021 ttaggatcaa ttaaagagca gtacggtaaa ggctctgtag ggtttatttc ttcttctaaa 2212081 attacgaatg aagaaaacta cgtcattcaa aaactagcgc gtcaggtatt tgaaacaaac 2212141 aacgtcgata actgctcacg ctactgccag tctcctgcta cagacggatt gttccgcact 2212201 gtcggcatgg gcggtgacgc cggcacgatt aaagatattg ccaaagcagg cctggtcatc 2212261 attgtcggtg ccaatccggc ggaaggacac ccagtgctcg caacacgcgt caaacgggca 2212321 cacaagctcc acggtcaaaa actgattgtt gctgacctgc gtaaaaatga gatggctgag 2212381 cgatctgatc tgttcatcag ccctaaacaa ggcacagacc aagtttggct gatggctgtt 2212441 acgaaatata tgatcgacca aggctggcac gatcaggcgt ttattgatga gaacgtcaat 2212501 tactttgaag attataaaga aacccttaaa acgtatacgc ttgattatgc agaacgcatc 2212561 acaggccttt caaaagaaaa catcattcaa attgctgaaa tgattcgtga tgctgacggc 2212621 acttgtgtcc tttggggaat gggtgtcaca caaaatacag gcggttctga tacatcagca 2212681 gccatttcaa acctgcttct cgctacgggc aactatcgcc gtccaggtgc cggcgcttat 2212741 cctctgcgcg gacacaataa cgtgcaaggc gcatgtgata tgggaacatt gcctggctgg 2212801 ctgccgggat atcagcatat tacagatgac aaagcacgcg ctaaatttga agaggcatat 2212861 ggtgtcgaga ttgatggaaa gcctggttta gataatattc aaatgcttca tgccattgaa 2212921 gaaggaaaaa tgaaagctat gtatcttgtc ggtgaggata tggcactggt cgattcaaac 2212981 gcgaaccatg tgcatgatat tttatcaagc cttgatttct tcgtggtaca ggacatcttc 2213041 ctgtcaagaa cagctcaata tgctgatgtc gtcttgccgg ccactccttc acttgaaaaa 2213101 gacggaacat ttaccaacac agaacgccgt gtccagcgat tgtatcaggc gcttccgacg 2213161 cttggtgacg caaaaccgga ctggtggatt attcaagagg tggcaaaccg tttaggagcg 2213221 aattggaatt acagccatcc aagtgacatt ttctctgaaa tggcgagtct ttctcctctg 2213281 tttgccaaag caagctatga ggtgcttgaa ggctggaaca gcttcctatg gggcagcttc 2213341 acaggtgaaa gcacaccgct tctgtatgaa gacggattta atttccctga caaaaaagcc 2213401 cgctttgccc tttctgattg gaccgagcca gcggcatttc cggaggaata tgaccttcat 2213461 atcaataacg gccggatgct ggagcatttc cacgaaggaa acatgacaaa taaatcgaaa 2213521 ggcatccaag cgaaagtgcc gaatgtattc gttgagatct cacctgagct tgcacaagag 2213581 cgaggtgttt gtgacggttc gcttgtacgg ctcgtttctc cgttcggagc agtcaaattg 2213641 aacgcgctga tcacagaccg ggtacggaaa aatgaactct atttgccaat gaactcgaca 2213701 gacaaggagt cagcgattaa cttcttgacg ggccctgcag ctgataaacg gacgaacacg 2213761 cctgcttata aacagacaaa ggtccgcatg gaagtgcttg gcggctgtga aacagcgccg 2213821 cttccaaaaa caaatccgcg caacaaaaaa cggcatccgc aaaacggagt cgaagcagaa 2213881 agaaaatgga accgccctgg ctatgtacat ctgactgatt aaacgatagg aggaaaacga 2213941 atggccactc cgattacgac gatcaaaaaa gaaacaaaaa cagctgagca aattaagctt 2214001 gaaaaaatag aagaactgaa agagctgctg gcggaaaatg aggacgccgt ctctaaaacg 2214061 atgacgttaa tgaatgaact caatgatctt ggaatttttg atgcggcaac aagcatgctc 2214121 agagcgaagg aagacattgc caagattgcg cttggccaag tttcccgcga gcctgtcacc 2214181 aacctcatca acacgatgat ggccgccgga ggcgcattga caaaagccga tcctgagttt 2214241 acagcaaagc ttttagaaag cgtaatggct gggactgaac aggcacaaag ctttttaaaa 2214301 gaagacaaga aagtcgggat tctcgacctg ttaaaagcaa tgaacgatcc tgacatcaac 2214361 agagccgtcg ggttcggcct tcagttttta aaaggcatgg gaaaagaact tcgagaacaa 2214421 taacagaaaa acagccatct ctgatgatgg ctgttttttt attcgtcggc ttcttccaga 2214481 cgcttcttgt aaataagtga acggtcagcg caaaagaagg caccggctaa aaatacgcaa 2214541 tccgctaaaa acatcgtcga tttctggcct aatgttaagc cttgatcagg gagaactgcg 2214601 cctatatata aaaaagtgct gactgcaagc aatgtaaaag caaaatgctt gtagtcttct 2214661 tttaaagatt tcattctatt tttgttcaaa agaatcacct gccagattca tagtatacga 2214721 ctattataat ataatccggc ggcttacaga gaaagtaatt ctatccattt gttatatatt 2214781 ttcaagcgct tggccgatat cttccaacaa gtcttccgca tcttcaattc ctacagaaat 2214841 tctgatcaag ccgtccgtaa tgccgagctc aagccggcgt tctctcggaa tagaggcatg 2214901 tgtcattctt gcaggaacag aaattaagct ttcaaccgcc cccaggcttt cagcaatggt 2214961 aaacagtttc agatttccta aaaacgcatc aacccgttct tcactgccaa tatcaaagga 2215021 gatcatgccg ccgaagcccg ctccttgcgt ttttgcaagc tcatgtccgg gatgatttga 2215081 agaaccaggg taatataacg tttggacagc agggtgattc tcaagaaagc ttgcgatttt 2215141 ccgcgcattt tgatcgatcg cttccattct gagtcccaac gttttgattc ctctcattaa 2215201 cagccaggaa tcttgagggc cgagcacgcc gcctgtggag ttttgcacaa aatgcagctc 2215261 ttctccaagc tctttcgaag ctgtcacaac taaacctccg acgacatcac tgtgtccgcc 2215321 aagatatttt gtcgcactgt gcagtacgat atcagcgcct aaagtaagcg gctgttgaaa 2215381 ataaggagta ttaaaggtat tgtctacgat aagcagaaca cccgcttttt ttgcgatatc 2215441 agccatgagc gtcaggtcgg tgattttgag caacgggttt gtcggtgttt caatataaat 2215501 tgcttttgta ttagggcgaa tcgctttttc aacttcttcc ctgctgctcg tatcaacaaa 2215561 tgttgattca atgccaagac ggttaagcac ctttgtcatc acgcgatatg ttccgccgta 2215621 cacatcatca gtcaacacga catgatctcc gctgttaaac agcatcataa ccgctgtaat 2215681 ggcagccatt cctgagctga acgcatagcc tgcttccccg ctttccagtt ctgtcacaag 2215741 tgcttcgaga gcggttcgag tcggattggc cgttcttgaa tactcgtagc ctgtatgctg 2215801 ccctgctttc ggctgcttgt acgtgcttac ttgataaatc ggcacggaaa ctgcgcctgt 2215861 tttctcatca cctgtgattc cgccatgtat catcaatgtt tttttcttca tatcagatgc 2215921 ctccttcgta tatttgtttg ctgatatatc gatcgctgct gtcaggaaat actgtgacaa 2215981 tgttagttcc agcggatgct tttttcgctt cctccaatgc cgcataaagc gctgcacctg 2216041 aagagcttcc gatcagcagg ccttcttttt ctgccgcttc tttcacaagt ctaaacgcat 2216101 tctcatctgt tacggtgtag atctcgtcaa aatggctctt atccatataa tcggggataa 2216161 actccatgcc gatgccctct gttttatgag cgtggggctc tcctccgttt aaaatcgagc 2216221 ccaccggttc aacaatcacc gttttgactg ctggattttt ttcttttaag aaggaagctg 2216281 tccctgcgaa tgtgcctcct gatcctgccc ctgcgacaaa tgtatgaata ttcccgtcaa 2216341 gcgcttccca catttcaggt ccaagcgtct tatagtaagt cgatggattt actcggtttt 2216401 taaattgcaa aacgcaataa gaattttcaa tttcagtctc cagctgaatg gctttttgaa 2216461 tggctccctg cattccgtct tgacgcggtg tatgaatgat tgatgcgcca agcgcttgca 2216521 taatttgctg tttctctctg ctgaaatgtt cagggacaca gaaaatcgct ttcagcccat 2216581 attttctggc acttaacgca aggccgatcc ctgtattgcc tgccgtagct tctataatca 2216641 ctccgccggg tttcactttg cctgaatcga gcgcgtcacg aatcagcata tctcccagtc 2216701 tgtctttgat gcttccccct ggattcatca tttcaagctt ggcatacacc gcgactcctt 2216761 ctggaacatc aaagttcttc aagcggagaa gcggtgtatt cccaatcagc tcggtaatgt 2216821 ccgtaatcac tgtcatatat gtcctcctcc ttaatagagg ttgtttttag agaaaaacgg 2216881 aggagaacgt tctccccgtt ttaatgaatt cgtttgatca cctttaacac aagctctgtt 2216941 gaatgaacag ccgcctgctc taaaaattgg tcaaatgaaa catgtgattc tttgcctgcg 2217001 atatctgata acgctctgat gacgacaaac ggcgttttaa attgatggca tacttgagcc 2217061 actgccgcag cctccatttc aaccgcgtac agatcagaaa atctcgcacg cacctcttca 2217121 acccgcttcg gatcgttcat gaaagaatcg cctgttgcaa tcgttccttt tgcaacctga 2217181 atgccgtcga gttcagatac cgcttcttca gtgatgctga tcagcttttc atccgccgca 2217241 taagcagccg gaagacccgg cacttggccg tattcatagt caaaagccgt tacgtctaca 2217301 tcatggtggc gaacgtcagt ggaaatgacg acatccccta cattcaatgt atgatgaaat 2217361 ccgccggctg agcctgtgtt aatgacataa tcaggcttgt aacggtcaag cagaagcgtc 2217421 gtgctgatag cagcatttac ttttccaatt cctgatttta aaagaatcac ttcagttcct 2217481 tcatattcgc ctgttgtaaa ttcacagtgt gcgatcgttt ctgtttttgc attttcaagt 2217541 ttgtttctta agatggtaac ttcctcttcc attgctccga tgactgctag tctcatctat 2217601 tcacattccc ttcactttac cgtttgatcg cctccattat ccacacgaag tcgttttgct 2217661 gagtgaatcg gactgcaaaa ccttcagctg taaacatttc tttcaacgca tccaatgtag 2217721 gataatgctc tgtctctaaa tcatttgcaa gctgataaaa gccttgagaa cgggctttat 2217781 cgatagcctg ttgatacgct tgcgcatttt caaagacggt atcggcaaac actattttat 2217841 catgcaagtg aaggtatttg ccatattgct ttatggcagc ccgcttttct tcgtcagtca 2217901 aatgatgaaa agcatatgaa ctgacaatcg tatcagcctg aaatggcggc tcagggaatg 2217961 tcaggaagtc tccatcaacg atttccgtcc tgcctgagag cttgtcagaa gccagtttac 2218021 gcattgctgg agaaggttcg attccaaata cagttttgcc tgcatcgagc agcttagctg 2218081 tcaaattccc ggtccccggg ccaaattcta acacatgcgt tccagatttt ctgacgatgg 2218141 catcaaggat atgatcgtag cctctgaacg cttctttata ctgaatatct aaaccttgta 2218201 ctgtttgatc ataagttgct gcccaatctt caaagagagg gataaattca cggcccatat 2218261 ttgtcacact ccatatttaa taattcctat aagtatacta tggattaatg atggaacagt 2218321 tcctataata ccacatattc tgaaaagcag gtactaaaac actttgtgta ttttatgcca 2218381 tctcatattg cgcattgacc gcaaaaaagc ttatacttca tatgacttgt gaaagctgga 2218441 gggtcaagac atgaattttc aattagatct gattaaagac aaagtggaat tttttgaagc 2218501 ggcttcattg caggagcttg aaaagaaaat caatacacaa attgaaaaca ataaagccat 2218561 catgctccgg gtgaaatctg tttcacacca aactcttgtg gcagaaggaa gaatattgta 2218621 cagcgcggtg gttcatttct cagctgaagc ctaaaacaaa agcagccggt tttaacccgg 2218681 ctgcttttgt ttattttagc ttttctactt ttgtcggctt ccagcctttt tcatcgaccc 2218741 atgtaatcgt gacttgatat ttattcccag tcgccttgtc caaaatcttg cctttggcat 2218801 cctgagggct gccgttattt ccaagccaga gcaccgtcat gttatctgtt gagacaccag 2218861 ttgcgtacga aatggctttc agcatctcag cccagtcttg tgagcttgaa tcataagtag 2218921 cggcatgctc gccagtctgc tcagttccga ctgctttcca gtcaggattt tcatacgttt 2218981 tttccacatc gctcgatgag ccgccttctg ttacttttgc atctttaagc ccgtcaccgg 2219041 ctgaatctga gcttgaatct gaatcagagt catctttttt agaagaagaa tcatcttttt 2219101 tggaatcaga gtcagaagac ttctcagaat ccttttcgct gtcagatgta tctttcttgc 2219161 tgtcttttat atcctcatcc gatttctttt ccgtctttcc tgaagccgga gattcctgtt 2219221 tttgcgccgt ttcagaatcc ttgctgacat ctttgctaga aggactgtta atgaagagat 2219281 tcgctgctac tacgacaatt agtatggata cgattgcgat taaaatgtta agcactaaat 2219341 tggcttttct gcgtttatca cgattttcat aacgagattg attattgctc aataattctg 2219401 cactccttta tccctcttgg ctcagcatat attttaacat gtgctgagaa gttgttctat 2219461 ttctgattga tttcaatttc gtgtactttt ttaacaatat cataaaacac cgaatttgtc 2219521 agagccttat ctcccggtgt atccatgtgt aaaacaacta gagcgtattt cggcttatcc 2219581 gcgggaaaat atccggcaaa ccatttttcg tagagcgttt ccttctcttt tgaaagcttg 2219641 cctgtctggg ctgtgcccga cttccctgct acagtatacg gaagatcttg aaaccttctg 2219701 cccgttccgg aaggagattc tactacccgc cgcagtattt tttgaagctg ctgtgacgta 2219761 tatttgtcta tcgtttcccc tttgagcttc tgatctttaa acgtaacgag cgttgtgccg 2219821 ttcttatact caatttgttc ggcaattttc acctgccgtt tttctccgcc gcgggcgatt 2219881 gtcgccatca tattggctac ctccagcggc gttaccttta catttttctg cccgattgct 2219941 gtttgcgcaa tggctttttt gactgatttg tctttttcat ccccccaaat cacgccgctt 2220001 ttttcgttat acagctggcg gaaatcggtt tcgtggtaca gttttccctc ccagcctgcc 2220061 cgatcagtga gagccagctt ctcggacata tcttcaataa ccgagctgtc ttttttcatt 2220121 aattgttctg caagactcgt aaatgtgtaa ttacagcttt gggcaaaact ttcatcaaaa 2220181 gacaaggtgc ctttgtcgtc ccccggttcc ccgtacaggt ttaaattgca attaaaggtt 2220241 tgactaggct tcaccatatt attttcgatt gcagctgcgg caatgactgt tttaaaaact 2220301 gatccgggat agattggcgt cagcatataa ttttgaagtg tgttttgccg ggacacgtct 2220361 gcatctggtt tgcttacaat tcccagaaca ctgctatttt cgatgtccag cagcacagct 2220421 cctccctttt tcagcccctg ttcatccaat acctcctcca tcgctttttg aatgctttga 2220481 tcgatcgttg ttttgatctg gagcggataa aatgtattgg cttcagctgt atatttgacg 2220541 tccatgccaa acaaagggtt tccttttccg tccacatgat ataaaagctt tgtgtcttgt 2220601 tccggaagca aaaactcgtc aaatgtccgt tctaaaccgg ttgttccgat ttctgttgta 2220661 atcggaaggc tctccttgtc aggatatttc ttgcgaagca gcgccggatc ttggttcgtg 2220721 ctccctatcg tatgtgaagc aaggctgggc ttgtcttcat tctccatata tacgccgtaa 2220781 atgccgggat atttcaaaga attgattttt gtgatagatt gttttgaaag tgttttgatt 2220841 ttcttttgct gcaaaatgac cggttttttt gcctgaccta gtgtctggcg caaatcatct 2220901 tcagacatgc cgaggatgtc cgcaactttt ttgatcggcc aatcctgcgt cagcagaaaa 2220961 gggaacaaaa caaccgcagg ctcgctttgt cctgtcagcg cccgcccgtt tcgatctaaa 2221021 aaagagcctc ttccatctga aatgagcact tcctccgtcc gctgtttcac actttcttga 2221081 atcaaattaa ttttcttttt agaaaatgat tctgtgaaaa acagctggat ttctgcaagt 2221141 ctcagcagaa gcagaaaaaa tacaatcaaa aaagcgatga ctgccagctt cattcgtttc 2221201 gatatcttca taaaaaaaca cctcacccac attgtggacg aggtgtttcg ctgctaaaca 2221261 gatattatga aattttcaca attttcacga gcatttctcc gcccggtgtt tgtactgtga 2221321 cttcttcatc tacttttttg cccaagaggc tttttgcgat cggtgaatcg tttgagattt 2221381 tcccttcaaa cgggtcagct tccgcgcttc cgacgatcgt atatgattct tcatcaccgt 2221441 caggcagttc gacgaaagtg acggttttac ccaaaccgac aacgttagag ccgccgtcat 2221501 cttcaatgat tttcgcattg cgaatcatat tttcaagagt cgtcacgcgg ccctctacaa 2221561 atgcctgctc ttctttcgct gaatcgtatt cagagttctc ggaaaggtct ccgaagcttc 2221621 tcgcaatttt gattcgctct actacttctt ttcgtttaac cgttttcaaa tattctaatt 2221681 cttgttcaag tttttgtttt ccttctgcag tcataggaaa aactttctct tgtgccatgt 2221741 cccttcactc cttctggttg tccctcaaca tcttcgatta tgtatgagag cataaactaa 2221801 aaaatacaag aatgagaaca cagggcagtc ctcgttcttc tctcccatat aggtactgtt 2221861 tatcttaaac tgaatcgtgt cgttctgcaa atatttcgcg tttataaaca gggaaagaag 2221921 ggaattcgca cattcccttc ctgcctatac ataatatggt cagagttatt tatgtctatg 2221981 ctatggtatt acaaaatcgc gttttgttca agaatggttt gaatttttgt gaccatcaga 2222041 tcaattgcga cgtgattctg accgccttcc gggataataa tatcagcgta tcgtttcgtc 2222101 ggctcgacga attggttatg catcggacgg accactgaca catattgttc aatgacagaa 2222161 tcaatagagc gtccgcgctc attaatatct ctcataatcc gtctgatgat acgcaagtca 2222221 gcgtccgtat caacataaag cttgatatcc atcagatcac gaagcctttt gtcttcaaga 2222281 acaagaatgc cttcaaggat aataacatcc tttggctcta cgtgaaccgt ttcttctgaa 2222341 cgtgtgtgaa gcttatagtc ataaatcggc ttttcaatcg ggcggtaatt caatagatct 2222401 tgaatatgct cgattaaata gtcattatca aacgcaagcg gatgatcata gtttgtgttc 2222461 agcctttctt caaacggaag atggctttgg tctttataat aaaggtcctg ctggatcatt 2222521 aaaattgagt gtcctttaaa ctgttcataa atggaccgtg tgacactcgt ttttcctgaa 2222581 ccggaacctc ctgcgattcc aatgactact ggattcttac ccatgggctg ttacttcccc 2222641 tttctcatca tgttgctcgg ataaatcttt ttgtctagtt tgaatttgac aatttgcagg 2222701 ggatggcggg cagcatctag ctcatttccg tcttcgtccc aaatggtttc aatcgtatgt 2222761 gtaaagtttt cgatttctgg accgaaaaat tccacttcgt cgcctttttt gaagaaattg 2222821 cgctgctgaa gcgtgaccat ttgtgtatct tcatcataat tcagcactaa gccgacaaaa 2222881 tcatatgtcg ttttcttggc gtgttcgccg aacatttgct cttcatagcc tggcgttcct 2222941 tcaaagaaag ctgtcgcagt gtccctgttg gcgcacttat caagctcttc aagccattct 2223001 ttttgaatca caaagttttc tggatcagcg caataagcat cgattacttt gcggtatacg 2223061 ctgacaacag ttgctacata gtgaatggat ttcatgcggc cttcaatctt taagctgtcg 2223121 atccccattt caatcatttt tggaatggat tcaatcagct tcaaatcttt cgggctcatc 2223181 gcaaatggtg catcttcttc accatacaaa gcaacggcgt tggcaccgtc tgtttggtag 2223241 agatcataat cccagcggca tgactggcag cagcctccgc ggttggaatc ccgcgctgtc 2223301 atgtgattgc tcagcacgca gcggccggaa tatgcaatac acattgcgcc atgaatgaag 2223361 gattcgattt cgatatctac cttttctttc atttctctga tttcaagagc gctagtttca 2223421 cgtgccagca cgacgcggtc gagaccttct tccttccaga actggacagc cttccagttt 2223481 gaaagagact gctgtgtgct caagtgaacc tcaacattcg gcgccactct gcggcatgtt 2223541 tcaataataa gcggatctgc cacaataata ccggcaacgt tggcgtctcc aagcgctttt 2223601 aaatagtctt caagcccgtc catgttttca ttatgagcga aaatattcgt tgttacgtag 2223661 atcttcgcgc catatttctt tgcgaattca acgccttctg caatttcttc gatcgtaaag 2223721 ttatcggcat tcgagcgaag cccgtattcc tgtcccccga taaagaccgc gtccgctccg 2223781 taatgaacag cgattttcag cttttcaaga ttacccgcag gtgcgagaag ctccggcttt 2223841 ttcgtaatca cacgctttcc attaacgatt gtggatattt tatcatttac ggcagtcata 2223901 gcttaacctc cttttgatta ataaaccgtt tccttgaaga agaatccggt atcaattttt 2223961 ctgtttactg gctggatgct ttcaatgcgt tcgatccagt cttctttttt cgcttcgtat 2224021 tcgtcacggt tttccacgca caaatcaatt gcttctctgt acattttggt gacttctatt 2224081 aggtattcag gcattttcaa aacaccatcg attttgaaag aatcaattcc ggcatctatc 2224141 aattcctcga gctcatcaat gatgcacaca tcgttcgggc tcatgatgtg agtgccgttt 2224201 tcatcttcga aaatcggata tttattatcg cgttctttat cgtgtaaaaa catgcctgat 2224261 tcttttttct ttctttcaat gtccatgact ttgccctgat attcaaaata gtttccaatc 2224321 aaagaacgct tcgattggaa catgcacgtc attccatgca cctggatttc aatttcgact 2224381 tcagcatttt ctttaatctc aacaatgctg tccatgttta attctctggc aagcacagaa 2224441 cgcgccgcac ccttgcgtcc ccagtagttg catgtataat agttggtgcc tgtcgtttct 2224501 gtgctccaat gaagcttcag atcaggcgca gattcacggg cagccatcag cacggcagga 2224561 tcgccgaata ccgctgcatc gacaccggct tctgctaaga aagccagata ttcgccaagc 2224621 tcacccactt tatcattatg gaaaattgca tttacagcaa cgtatacttt tgccccttct 2224681 ttgtgagcaa tctctacggc ttttgttaca tcttcacgag aaaattctcc ggctaatctc 2224741 aagccgtatc tctgttcccc aactaaaaac gcagttgccc cagcctgtat gagcggcaaa 2224801 atgtccgctg tactcgtcgg cgtcactaag agctctggtt ttttcatgac gttcacctct 2224861 tctttttact aatcgcaagt ccgtccccga caggaataat cgcagtttga taatccggat 2224921 gattcatcag ccaatgatta tattcatcaa ttttggctac aagcctgcgc cttctcttcg 2224981 gttctatttt gctgtaatcc tctgccacca gacctttaaa cagcacgttg tctgttataa 2225041 tcaccccgtc cggtgaaagc atcggttcat ataaatgaaa aaagttttga tactgacctt 2225101 ttgcagcgtc aataaaaatg acatcgtaag gcgcggttac atgaacggcg tcggctaatt 2225161 caagcgcatc tccgtaaaaa acatgaatcc ggtcatcaag ctgaaattcc ttgatattgt 2225221 ttaccgcttc ttcatgccgt ttctcattgc gttcaattgt atatatttca gcagacggca 2225281 gttccagagc cattcgaatg gctgaataac caatggccgt tccgatttct agtatttttt 2225341 tcggctgttt cacagacaaa atttgaagca gcacctccat gcccgctttt tccataatcg 2225401 ggacatgatg ttcttctgca tatgcttcaa gtctcttcac gttatccggc cgaggcttta 2225461 ataatgcttc tatatagtca tttatttgtt cataccggtc agtcactaca aacagcctcc 2225521 cgttctaaaa aggagtgccc cagtcttatg cgcaggacac tctctgaata catcatgata 2225581 catcggtaaa caacccgata tattttatca taaaaccttg cggaaagcga acaaaaggag 2225641 agctttttgc tctcctttta tttctcattt tttgaggaaa tgtatttttc ttttgcttta 2225701 ttatgctctt ttagcgtttt tgtaaatacg acctcaccat ttgatttggc caagaaatac 2225761 agatagtccg ttttatccgg atgcagcgct gcttcccatg atgacatgcc ggcattggca 2225821 atcggccctg gcgtcagccc tgtgttttta tacgtattgt atggtgaatc gatttccaga 2225881 tccttataaa gaacccgatc tttatgcttg cctgccgcgt acaggacggt cggatctgtt 2225941 tggagcggca ttttcttttt caggcggtta taaaagacgc tcgcaatttt atggcggtcg 2226001 gctttttcag tcgcttcttc ttctatcaaa gaagccattg tcagcagctt atgcacagaa 2226061 actttgtttt tcttcatttc tgatttatat gtttccacat aagaatttgt ctgcttaatc 2226121 attgccttga taatgtcttc aagtgatgtg tccggatcgt taaaagggta tgtagccggg 2226181 aataggtacc cttcaagcgg gtgcttaatg tttttattga aaacatcatt tgtcacagtg 2226241 tccgggaatt ctttcttcag ctgattgata aatgtttcat cgtccagctt cgctatgact 2226301 tgttttttag agtattttgt ttcatcagca atagcagccg cgatttgggt cagctgtgct 2226361 ccctcagtca ctgtgatttg aaaagcgtaa cctgtagccc cgcttgtcag cttctgaata 2226421 atggcatcta aatccatacc tttattcaga tggtagaatc cggcctgaaa cccggaagca 2226481 cctttatatt tcacatagta ctgaaacgcc ttctcgcttt ttatgacatc atttttcttt 2226541 aatatcgatg cgatggctga aacagacgaa ccgctcggaa tgttaatatt aactgtcgtt 2226601 ttactgtctt tttcaacagg ttcaagcaat gatttcccat ataaaaatgc cccgccaatg 2226661 atgagaaaca gcacaacaat ggaagacagt atgattcttt ttttattaaa aaacgatttt 2226721 ttttgctgat tgatatacat taggtctcct cccatcagct cttatactac atgattcatt 2226781 gtatttcggc aatttattac aaaaagaggc ctgcataaag cagaaaaaag ccggagcagt 2226841 atagctccgg ctttggtttg gcgcgatgtt ttactcttcg tcttcgtccg ctaagaatgt 2226901 gtttagtgtt tcttcgatca tatcccattc ttcgtcagtt tcaatcggga atagctcacc 2226961 gttttcaccg tcttcgtttg gcgtgaagct ggaagcaaga atttctactt cttcgtcatc 2227021 ttttgattcg attggatagt acaagacata agatttgcca aactcttcat tttcaaatgt 2227081 aaacagcact tcacaaagct gttcatttcc ttgatcgtca acaattgtaa tatttttttc 2227141 gccgtgttcc attttcttca cctctggctt taatttaagc tgtcaagata tccttgtaaa 2227201 atcataacag ccgccatttt atcaatgact ttttttcgtt tttgcctgct gacgtcagct 2227261 gcaatcagca ttttttcagc cgccattgtg gtaagacgct cgtcccacag cacaacagga 2227321 acattgtacg ttgtttcaag cactttcgca aatgtttggc tggcttcgcc tctcgggccg 2227381 actgttccgt tcatgttctt aggaaagccg agcacgattt tatctatagt atagtccttt 2227441 atcagttcag ataaacggga taaaccataa tcgccttctg cttcatttat ctttatggtc 2227501 tcaatgcctt gagcagtcca gcccatttca tcgctcagag ctacaccgag tgttttggtt 2227561 cctaaatcga gtcctaatat tctcattctt tatttacgcc tctttatgct gttctaaata 2227621 agactttacc aattcctcga ttaattcgtc tctttcaagt ttgcgaatta aattgcgagc 2227681 gtcacgatgc ctaggaatat aagcgggatc acctgacagc aagtatccga caatctggtt 2227741 gattggattg tagccctttt cctgaagcgc gtcatacact gtaatcagca cctcatttac 2227801 gttagtctca gcagaatcat cggagaaatt aaatttcatc gttttatcaa acgagctcac 2227861 cgttttgcac ctctttccca aattcgcagg caaagttcag cctggggtcc taatcttacc 2227921 atcattctac actacatggg cgaattataa aacggatttc acccaatctt ctacagaagc 2227981 caaagcttct tctaattttt ccggctgttt accgcctgcc tgcgccatgt ccggacggcc 2228041 tccgccgcct ccgccgcaaa cttccgcagc ttgtttaacc agcttgccgg cgtgaagtcc 2228101 tttctcaatg aggtcctttg tgactccggc agagatatta actttatcgt tttgtaccgc 2228161 accaagcacg atcaccgcag agccaagctt tgctttgagt tcatcgacca tagtgcggag 2228221 atgattcatg tcttttgcat ttacttttgc cgcaagcacg tttacgccgt caacttcttt 2228281 tactttcgac aggattgctc ctgcttccac gttgcctagt tttgcaagaa gagattcatt 2228341 ttctctttgt gcatccttca gttcagcctg cagagccgcg acccgtttcg gcacttcttt 2228401 gatatttgtt ttcagctcgt cagcggtctg cttcaataca gaaatctggc tgttcatttc 2228461 gacgtaagcg ccttgtcccg ttacagcttc aatccgtctt gtgcctgctc cgattccgga 2228521 ttcagaaacg attttaaaca agccgatttc tgctgtattt ctgacgtggc agccgccgca 2228581 cagctctaag ctgtaatctc caacttgaac gacacggaca atatcgccat atttttcgcc 2228641 gaacagtgcc atcgcaccca tttcttttgc ttcagcgatc ggtttcaaat caatgctgac 2228701 cgggatgctc gcccagatct tttcgtttac gattctttca atttgttcga gctcttcttt 2228761 tgtcacttgg ccaaagtgcg agaagtcaaa acgaaggcgg ttttccgtta caagagagcc 2228821 cgcctgattg acatgagttc caagaacatc ttttagagcc tgatgcaata aatgcgttgc 2228881 cgtgtggttt ttaatgacgc cgcttctcat atggtcttca acttcagccg taacatgcag 2228941 gcctttttga acagtaccgc tctccacaac accttcatgc acatgctggc cgttcggcgc 2229001 tttttgaaca tctttaattc ttacaactgc ctgctcgctt cggagatagc ctttgtcgcc 2229061 gatttggccg ccgctttctg catagaacgg tgtttcatca agaatgattt gaacgctttc 2229121 tccttcatga gcctcttcga ttaattggcc gtcctgaaga agcacaatga tattggcatc 2229181 agctttggtt tgagagtagc cgacaaatgt gctttcaact gtcacgtcgc gcagtgcgcc 2229241 gccctgcacc tgcatgctgc cgacatcctg gcgggcgttt cttgcccgtt cacgctgctg 2229301 gttcatttcc tcctcaaagc cctcatggtc aaccgtcatg ttctcgtctt ctgcgtattc 2229361 ttcagtcaat tcaaccggga atccatacgt atcatacagt ttaaacacat cagcacctga 2229421 gataacgctg ctgcccttgt ctttttcttt tttgatcatt tctgacagga tcgcaagccc 2229481 ttcattaagg gtctcatgga agcgttcttc ctcggtttta atgacttttg cgatgaaatc 2229541 cgctttctct ttcacttcag gatagaaatc agccatgatt tctgcgacaa ccggcactaa 2229601 atcaaacatg aacggacgat ggatgttgat cgttttggca taacgcacgg cacggcgtaa 2229661 taagcgtctt aatacatagc cgcggccttc atttgacggc agcgcaccgt cactgacagc 2229721 aaaggcaacc gttctgatat ggtcagcaat cactttaaac gcagtgtctt tcacattgtc 2229781 tttgccatat gtttcaccag aaatcgattc tgttgcttta atgatcggaa caaacaaatc 2229841 ggtgtcaaag tttgtcggaa cattctggat gacagacacc attctttcaa gacccatgcc 2229901 tgtatcaata tttttctttg gaagcggtgt gtacgtgccg tcagggttat ggttgaactc 2229961 tgagaacaca aggttccata cttccaggta acggtcgttt tccccgcctg ggtaaagctc 2230021 cggatcttct ggatcattac cgtatgcttc accgcggtcg taaaagattt ccgtattcgg 2230081 tccgctcggc ccttcaccga tatcccagaa gttcccttcc agacggataa ttctttcttc 2230141 aggaataccg atttttttcg cccaaaactc atatgcctct tcatcttcag gatgaaccgt 2230201 aacagagaga agctctttgt cgaagccaat ccacttgtcg ctcgttaaaa actcccaagc 2230261 ccatgtaatg gcttcttctt tgaaataatc gccgatggaa aagtttccga gcatttcaaa 2230321 gaaagtgtga tggcgcgcag ttttacctac attttctata tcgtttgttc tgatcgcttt 2230381 ttgagcgttt acgattcttg gattttccgg cacgacacgg ccgtcaaaat attttttcag 2230441 cgtcgcaaca ccgctgttga tccaaagcag tgaaggatcc tcatgaggca ctaatgacgc 2230501 gcttggctct accgcatgtc ctttttcttt aaagaaatcc aaaaacattt gacgcacttc 2230561 cgcagaagtt aagtgtttca ttgtatttcc tcctctataa aaatcgaaat tctcttcagt 2230621 gacagcaaaa aagccctccc cctatgcaaa ccaacgttta cacagggacg agagctgtct 2230681 cgcggtacca ccctgattac gggcattcat gcgcccgtca cctttaaccc tgtaacgcag 2230741 gataagcggc agtgattaac tgcactcagg attagcttcc tccgatcttc tgataaagct 2230801 cctttcagct tatggagctt ctctctttaa cagggcttcg gcgtactcag atccgtcact 2230861 cgagattcgt atgtattcta cgagaaatta tagacaagcg gcacgccgat gtcaatgctc 2230921 cgtcctcatc cgcaaaaaat ggatcatcat tacttttaaa acagccgtcg caggaacagc 2230981 cagaatcatc ccgacgatac ccgcaagctc ccctccggca aggagtgcaa gcatgataac 2231041 gaccggatgc attttaaggc ttctgccgac aatgaacgga ctgaggatat ttccttccat 2231101 aaactgcaga ataaacaccg taatcaccac aacaagaacc gccttgactg agatcgtcat 2231161 cgcaattaac aacgcaggaa cagctccgat gaaagggcca aaatacggga tgacattcgt 2231221 taccccagag ataaggccaa gtatcagcgg atacggaagc ccaaataccc agaacgaaat 2231281 gcctgcaatc acgccaagaa tcaagcagac caaaagctgg ccgcggatat aatcgccaag 2231341 cgaatcatcc acatcccgca aaaaggcgct gccccgcttt ctccacgact tcggagtcaa 2231401 gtaccatact gtctttttca ttaactcaat gtccttcacc atataaaaca cgagaaaagg 2231461 gattgttgca gcaattaaga agtaatcaag cacattgcgg atcccgctga tcgcaccctc 2231521 gatcgttccc gcaaaaaacg cctccgtctg gcggatcatt ttatctatac ggtgatgcat 2231581 accatcaggc cagtcatccg tatggttatg cacatgaaga agaagcccgt tatacgtttc 2231641 ggcaaacatg ggtatatttt ctgacaaatc cgtcagctgc acgattaaaa caggcacccc 2231701 tttatacaac gcccagccaa tcccgccaaa aaaaagaaca taaatgacca agatgctcaa 2231761 agtcctaggc aatcctttgc catgcagcca ttctgtgacc ggaagcaata aataagatat 2231821 aaaaatagaa atgatcaagg gaataaagat cgtttttatg acgagccaaa agggtgacca 2231881 taacatatca agcataaaaa agacatagac tgttaacaga accagcaaac aaatagccac 2231941 ccacaacaaa agctgcaccg gtttttggag catctgcttt cacctcacct atatcttttg 2232001 aggtttacaa ggaattattc tttatgtttc tttagtcagt cagaagtcat ggacattttt 2232061 tcacttttaa ttttcagaaa agtttgatca tttacttttt ggtcaaattt tctgatagga 2232121 ggattgcgat gatcacattt caaaatgtaa acaagcatta cggagatttt cacgtgttaa 2232181 aacaaattaa tcttcaaatc gaaaaaggtg aagtcgttgt tatcatcggc ccatccggtt 2232241 ccggtaaaag cacattgctc agatgcatca acagacttga gtcgatcaat gagggagtgc 2232301 ttacagtaaa cggcaccgcc attaacgaca gaaaaactga tatcaatcaa gtgcggcaaa 2232361 atatcgggat ggtgtttcag cactttcatt tatatccgca taaaacagtg ctgcagaaca 2232421 tcatgctggc tccggtaaaa gtgcttagac aatcacctga acaagcaaag gaaacggcgc 2232481 ggtactatct tgaaaaagtc ggcatcccag acaaggctga cgcctatcct tcccagcttt 2232541 ccggcgggca gcagcagcgt gttgccatcg caagaggact ggcgatgaag ccggaggtca 2232601 tgctgtttga cgagccgaca tcagcacttg atcctgaaat gatcggtgag gtgctagatg 2232661 tcatgaaaac actcgccaaa gaaggcatga caatggttgt cgtgacacac gaaatggggt 2232721 ttgccaaaga agttgccgac cggattgtct tcattgacga aggaaaaatt ttagaagaag 2232781 cagtgccggc tgaattttac gcgaacccga aggaagaacg ggcccgctta ttcttaagcc 2232841 gtattttaaa tcattaaaac agaaatgggg gagcttgtat gaaaaagatt ttttctttag 2232901 cattgatttc tttattcgct gtcatcttgc ttgccgcttg cggcagcaag ggatcaaacg 2232961 gagaagcctc aaaggagagc aaaaaagata cgctagccgc cattaaagac aatgacaaaa 2233021 ttgtcttcgg cgtaaaaacg gacactcgac tgttcggtct taaaaatcca agctcaggtg 2233081 agattgaggg ttttgatatt gatattgcta aacaaatcgc taaagacatt ttaggtgatg 2233141 agaaaaaagc tcaatttaaa gaggtcacct caaaaacaag gattcctatg ctgcaaaacg 2233201 gggatatcga cgccattgtc gccacaatga cgatcactga agaacgaaaa aaggaagttg 2233261 acttttctga tgtctatttc gaggccgggc aatcgcttct cgtgaaaaaa ggcagcaaaa 2233321 tcaagagtgt cgagaatctt ggcaaaggct caaaagttct tgcagtaaaa ggctccacct 2233381 cctctcaaaa cattcgtgaa aaggcgcctg aagcatctgt tttagaattt gaaaactacg 2233441 cagaagcctt tacagccctt aaatcggggc aaggcgatgc cctcaccaca gataatgcaa 2233501 ttttatatgg aatggctgat gaaaataaaa attatcaatt aacaggaaag ccttttacag 2233561 atgagcctta cgggatcgcc gtgaaaaaag ggcaatctgc tctcgcgaaa gaaatcaacg 2233621 cttcacttaa aaagatgaag tcggatggca gatacgatga aatttataaa aaatggatca 2233681 aagaagaccc agctgaataa caaccatccc gggatgagca ggcgatgctc atcccaattt 2233741 gataaggagt gaataggcag atgaatgtgt caattctttt cgataacttc agcatgtata 2233801 tggacggttt ttaccatacc ttgctcgcaa gtgttatcgc gctggccggc agttttgtcc 2233861 tcggcgttgc tgtagcggtt atgagaataa cagtctttaa gccgctgcaa tggctcggga 2233921 ccgcatatgt agaattcatc cgcaacatcc ctcttctttt aattaccttt gttttctatt 2233981 tcggacttcc aaacgcaggc ctgaggcttg acggttttca agcgggaacg gttgctctca 2234041 ccatttatac ctctgcgttt atcgctgaag ccatcagagc aggcatccag tctgtttcaa 2234101 aagggcagat ggaagcggca cgctcgtcag gctttaccta cagccaagcc atgctccata 2234161 tcattttgcc gcaggcaatc aaaatcgtca ttccgccttt aggcaatcaa tttttaaact 2234221 tagtcaaaaa ctcttcgatt cttggggttg tggccggatt ggatcttatg taccaagccg 2234281 atttagtttc gtcgagcaca ctcgttgtat ttgatgttta tatttttgtg gcgctttttt 2234341 acttagtgct gacgattccg cttagcatcg gtgttaacta tctggaaaaa cggctggaaa 2234401 aaagctattg ataaggagtg agttacattg gatttcatcg gtgcttattc acaggagcat 2234461 ttagcgtttt tatgggatgg ctttctcgtc accttgtacg ttgctttcat ctccatcatt 2234521 ctgagctttt tcttcggttt aatcgcaggc accctgcgtt atgcgaaagt tcccgttctt 2234581 tctcaattga ttgcagttct cgttgaaacg atcagaaacc tccccttgct gttaattatt 2234641 ttctttacgt tttttgccct tccggaaatt gggattaagc ttgaaattac agctgctgca 2234701 attacagcac taacgatttt tgaatccgct atgctatctg aaattatccg aagcggactg 2234761 aaatcaattg acaaaggaca aattgaagcg gcgcgctcct ccgggctgag ctatacacag 2234821 accctgttct ttatcgttat gccgcaagcg cttcgccgca tggttccgcc catcgtaagc 2234881 cagtttattt ctttattaaa agatacatcg ctcgctgttg tgatcgccct gcctgaactg 2234941 attcacaacg cgcaaattat taacggccaa agcgctgacg gcagttattt tttcccgatc 2235001 tttttacttg cggcccttat gtatttcgca gtcaactaca gcctttcact cgcagcaaga 2235061 cgcctcgagg tccggcaaac atagaaaagg atactctttg gagagtatcc tttttgcatt 2235121 aaaacatttt cgtaattctt cttctcatcc gcttcatgct tcgattattc agcatgtcag 2235181 attgagtcgc cattcggtac acgagagctc cggctcccat tgccaaaaga gaagtcatcg 2235241 tccgattcat cctgcgcatc tcctttcatg attaaaaatt gatgctgcgt tcatcctcag 2235301 aaaacaaatc atccaagctg cttaacgttc cgtcttcttc cacctgatga gttgcaatct 2235361 tccctttcgc cactgtcagt tcaataaaac agccccagca ataatattgg ttcacgccga 2235421 ttttgccgat atccttactt ttgcaattcg ggcatataag catacctcac acctctatcc 2235481 gttcagaacg atctcgtctt tccgcacctc gacaagcgaa tccgctcttt ggatctggcg 2235541 cttgcttccc gccaggtcag aaaagaaacc gtccgagagt tcatatgcta cgattatgcc 2235601 cctgtccaaa caaaagtata catcttccag catccccaat atatccccct cttgcgattt 2235661 cacaagcttc atcttcatct gctcgtatgt gaagcatgat ttcggaagag gcaaaagctg 2235721 ttctgaactg accgaagcca atatgcggtc atcaaaaatg gaagagatat cacacgcccg 2235781 taatagcgca tgatgatgat gcaaaaagcg tttttgtgca agaataaacc caagacaatc 2235841 tcctttcaga gaaaaacaaa tatcggaaat tgtcccgaga taactagaag ttcgttctga 2235901 gtatactggg aatccttcta cttcatggca tgttctcaaa gtgtgatcaa ccaccttttg 2235961 ttgaacaggc ttaggttttg ctttgcgcct tagactcata cgatgaaatc aattccactg 2236021 caaatgaaaa aaaactcccg cttgcacggg agcattttat tgctgttctt ctttcataaa 2236081 atcgaatggt gtaatgcctt ccatgccaat gttggcgtcg tgtacgctga acgggagctc 2236141 tttttgcaaa gcttcaagct cggcatccat ttcctcaacc tgtacggaca gcctgttttt 2236201 caaggaggtc tgtctgacag ttgcatcatt atttttcacg ccccactcca gcgcctcctc 2236261 ttccccgcat aaaatgagaa atttcttcgc tcttgtaatc gcggtataaa gaaggtttct 2236321 tctgagcatt ctataatagc ctttcacaac aggcaaaacc acaatcggaa attcacttcc 2236381 ctgcgattta tgaatagaac agcaatacgc atgggtaaat tgattaaaat cttttttcgt 2236441 aaatgtcatt tcattgccgt caaaagaaac gacggccatg tcttcttttt ctgtattttc 2236501 ctttgcataa aatatcgacg tgatttcgcc aatatctccg ttgaacacat tgttttccgg 2236561 ctgattgaca agctgcaaaa ttttatctcc ggttctgtag acaacatccc cgaacttcaa 2236621 ttctctccgt ttttctttag gaggatttaa aatgtcctgc agcatcacat tcaattcatt 2236681 aatgccggct tttcctctgt acatcggagc gaggacctga atgtcctttg ctgtatagcc 2236741 ttttttcaat gcattggcga caaccttctc aactacttct ttgatttgcg acccgccgca 2236801 gcgaataaag gaacggtcct ttgtcggggc agtcaaattg ttcggcagca atccattttt 2236861 catctggtgg gcaagctcga cgattgatga cccttctgcc tggcgataga tgtctgtcag 2236921 tctcacagtc ggaatcacct gggatgccag caggtctctg agcacttgtc ccggaccgac 2236981 ggaaggcagc tggtcttcgt ctccgacaat gatgatttgt atatgatcag ggatcgcctt 2237041 gaacaaatga ttcgccagcc atatatcaag catactggct tcatcgataa ttaacagctt 2237101 cccttcgatc ggctgatcct ctgtatgagt aaagccttca gcgccgttcc agccaagcag 2237161 cctgtgtatc gtaactgcag ggagtcccgt tgattcactc atccgttttg ctgctctccc 2237221 tgtcggagcg gccaaaacaa tcggaaaagc ttcatccttt ttataagctg acgggtctag 2237281 tgacacaccg tgaagctctc cgtagagctc gacaatccct ctgattaccg tcgtttttcc 2237341 tgttcccggg ccgcctgtta aaagaagcat cggcgaggaa agggcttttt gaatcgcttc 2237401 cttctggctg ggggcatact gaacgtccat ccgttcttcc agttctccca acgcgagcaa 2237461 aaactctgat tcgggaaact ggttctcata ttcggtttgg ctagcgatat gtttcacacg 2237521 ctttgcaacg ttttgttctg cgtaaaacag cgaaggaaaa taacagcggc catcttctat 2237581 gacaatgtct ttattttctc caagggcaat aattgcgtta gcggcatcca tttctgtaat 2237641 gcgctgccct tcccttgctg actggtttaa cagtgattga gtgtcgatga tcagctgttc 2237701 cgtttctatg tacgtgtgcc cctctgacag acaagtcgtt tcaagcgtgt acaaaatagc 2237761 agcttttacc cgctcaggat gattacccga aagacccatt ctgctgccca gctcatccgc 2237821 ttttccaaac ccgatgcctt ctacatcctt cacaagctga taaggatttt cctgaatctt 2237881 ttcaagcgtc tcggattcat aggcttgata gattttcata gacagctgcg ggccaaagcc 2237941 aaactgattc aaggaaatca tgatttgctc cagtccctga tgccgctgca atgcgccagc 2238001 cagcgtgtct gctttctttt ttgagagtct gggaacatca taaagcactg aagcatcagc 2238061 caatatttta ttaatggcgc tgtcgcccag ctttttcaca atttcttcag ctgttttttt 2238121 gccgatcccc tcgaataaat cactcgataa atattgaatg atgccttcct tagtcgttgg 2238181 aatctccttt ttgaaatgct ccgcctgaaa ttggagcccg aattttggat gggttacgat 2238241 ctttccgtaa aacgtgtagg tctcttcttc ttgaagcgca gggaagtagc ccgtcacgga 2238301 tacggcttta tcttcaatgg cttcggaggt ctctgtgact ttcactttca gaaccgtata 2238361 taaattggtg tcattatgat agatgactgt gttgactgtc ccttttaaat agggctcttc 2238421 ctccagttta agctgatccg gatgctgctg cacgagctgt ccctcctcct gtgcctgtta 2238481 tgatggatca atcagttttt tagcatgaag cgcaagcata tgatctggct ggatatcgat 2238541 tgccttgtcc agcatttcca gcgctttttc tcggttttct ttataagcat aagtgacacc 2238601 ggcattataa aatgcatctg catgccccgg gtcttgctct gtcacagctg cgaattggct 2238661 gagcgcttcg tccagcatgc cctcgttggc taagcacatc ccgaattgaa aacgcgcttc 2238721 cgtatcgttt tcattcagtt cgactgctct ttgtaaatat ggcagtgcaa gcttaggctg 2238781 ttcgagcttg acaagtaccg ttccgagcat gtaaaacagg tcgccgtttt ccatccccgc 2238841 acgtagcgct ttttcaaaca tgtctttcgc ttctttgtac atttctttta caacatagac 2238901 atttcctgct ccataataag cagtggctgc gctactgtct aattcaagcg ctttatcata 2238961 aaacgcaagc gcacgttcca gctcgtttac ggatgaaaga aggttggcaa aattgatata 2239021 cggaatcgcg tcttctttat tttcttcaat cgcttttgta aatgcctctg ccgctttctc 2239081 gtaatcgcct tcctgcatcg cctctatacc gagttgatta taatccaccg atcatcttcc 2239141 tttcattaaa aaaccccaac tcagtgttga ggtttttcat cttttatacg taccacaatt 2239201 ttgttccgtc tttgtacaca tcatcaattg tcccgccgcc aaggcattct tcgccgtcat 2239261 agaagacaac ggcttgtccc ggcgttacag cgcggacttg ttcatcaaag atgacttccg 2239321 cttcaccttc gccagtcatg cgcactgtta ctttatgatc ctcttggcgg taacggaatt 2239381 tagccgtgca ggaaatctct tcgcccttca tgatatccga acgtacccag ctgatatttg 2239441 ttgctgtgat tttgtcggaa tataaaagcg ggttatggaa cccttgatct acgtagagga 2239501 tgttcttttc aagatctttg cctaccgcaa accacggctc gccgcttccg ccgatgccaa 2239561 ggccgtgacg ctgtccgatc gtatagtaca tcaacccgtc gtggcggcct tttacttcgc 2239621 cgtccatcgt catcatatcg cccggctgtg cagggagata ttggctgaga aacgttttga 2239681 agttgcgttc gccgataaag cagatgcctg tactgtcttt tttcgtcgct gttgcaagtt 2239741 ctgcttcttt ggcaatttca cgcacacggc ttttttgaag ttcgccgatc gggaacatga 2239801 ctttgctcag cgtatcttct gtcagctgat tcaggaagta cgtttgatcc ttgttttcat 2239861 caatgccgcg cagcattctg acttttccgc cgcttctgtc tactcttgca tagtggccag 2239921 tcgctaaata gtcggcgcca agtgacaatg catgctccaa aaaggccttg aatttaattt 2239981 ctttgttgca caatacatcc gggtttggtg ttctgcctgc tttatattca tcaaggaagt 2240041 attgaaatac cttctcataa tattgctttt caaagtttac ggcataatac ggaattccga 2240101 tttggttgca gacgcggatc acatcttcat aatcctctgt cgccgtgcaa aaaccgtttt 2240161 cgtccgtatc atcccagttt ttcataaaga ttccgattac atcatagccc tgttctttta 2240221 acagcagggc cgccacagat gagtctactc cgccggacat gccgacgacg actcttgtat 2240281 cctccggccg tttttccatt tcattcactc caattactac gccgccttat tatgtcagcc 2240341 gtttgacaac gtcggccaca tgtttggcag cagttttcac ttgctcagcc gtattgccga 2240401 ggccgaagct gattcgaata gaggacgtca gccggtcact ctcttcgccg aacatagcag 2240461 tcagaacatg tgacggcagg actgaaccgg ccgtgcacgc tgaaccgctg gagacagcga 2240521 caccagccat atcaagatta accagcagcg cttccactga cacaccgggg aaataaagat 2240581 tcagaacatg cggcagacta tgctctttgt ccccgttgac ctcgaatgcc acacctgcat 2240641 ctctaagcgt gtcggcaaag attgctttaa acgattgata cttctcgttt ttttcgtcac 2240701 gttcttcact tgacagcttg atcgcttctt tcagcccgac aatgcctgga acattttccg 2240761 ttccggcacg gcgttttctt tcttgctctc ctccgaataa aaggggtgaa agcttcacat 2240821 ctttactagc atataaaaag cctgtccctt ttggcccgtt gagcttgtgc ccggaaacag 2240881 acagaaggtc aatatggctg tttttcacat caattggcag caacccgaat gcctgaacag 2240941 catcggtatg aaaataagct ttgtgttcct ttaacagctc accgatttct tcgatcggct 2241001 gcactgttcc gacttcatta tttccataca tcactgtcac aaggattgta tcatcacgca 2241061 gtgcttcttt cacctgtttt gcactgactc ttccattttg gtcaacgtcc agatacgtta 2241121 tgtcaaatcc gtctccctca agtttttcac atgtgtgaag cacggcgtga tgctcaattt 2241181 ttgttgtgat gatatgtctg ccaagatctt ttcttgcaag tgcggttccc atgatcgcca 2241241 agttatcagc ttccgttccc ccgcttgtaa aaatgatctc ctgctctgcc gctccgattt 2241301 ctgctgcgat ctgcgctctt gcttcatcca cccattttcg agattctctg ccaaatgaat 2241361 gaatactgga gggattaccg aaactgccgg agaagtgcgg tatcatttgt tccagcacgc 2241421 gctcatccat cggagacgtt gcggcatgat ctaaataaat ccgttccatt atgtttacac 2241481 ctctgatcta aatatagaac atataagctt cttgctctcc gtctgtatag ctggcaagat 2241541 cctctaatgt tgtactgtct aaaacctctt ttacagcatc ccggatgcga atccagagct 2241601 cacgcttggc aggctcctca tcttccagca cttcaacagg gctgatcggc ccctcaagca 2241661 cacggataat atctcccgca gtaatggcat ccggctcact gcctaataca tatccgccat 2241721 atgcgcctct gatgcttttc actaaaccgg catttctgag cggcgatacc agctgctcca 2241781 aataatgctc ggacaaatta ttcgtctgtg cgatgctttt taatgaagtc gggccttcac 2241841 cgtgcttttt tgcaagctcg atcataatgg tgagcccgta tcttccctta gttgatattt 2241901 tcaacatgaa cacctctgtt atttcatgat tttccacatt tataatggta atttctatat 2241961 gtttcgtccg tttattatct tatagaccaa ctgttattat aacatacctt cagcgaattt 2242021 tcattgaggc agaaggaaag gggcctttac ccttttctaa tgtacggttt tccgttaccc 2242081 tgtaattaag taaggagaga tgatagatga agccattggc atatcggatg cgtccgacaa 2242141 aaatagagga tattatcggc cagcagcatc tggtggctga agataaaatt attggcagaa 2242201 tggtccaggc aaaacatttg tcatccatga ttttgtacgg gccgcccgga attggaaaaa 2242261 catcaatcgc aacagcaatc gccggttcaa caagtattgc ttttcgaaag ctgaatgctg 2242321 tcattaacaa taaaaaagat atggaaatcg tagctcagga agccaagatg tccggccaag 2242381 tgattttgat tctggatgaa gtccacaggc tggataaagg aaaacaggat tttctattac 2242441 cctatttaga aaacggaatg atcattttga tcggagcaac gacggctaac ccgtatcatg 2242501 ccattaatcc ggcgatcaga agccggaccc agatttttga gcttgaaccg ttaacacctg 2242561 aactgattaa acaggcactg gaacgtgcgc tccatgatga gcatcggggc cttggcacct 2242621 attctgtatc cattgatgat caggcgatgg agcattttgc ccacggatgc ggaggagatg 2242681 tccgctccgc tttaaatgcg cttgagcttg ccgtgttgtc aacgaaggag tcagcagacg 2242741 gtgaaattca cattacatta gaaaccgcgg aagaatgctt gcagaaaaaa agcttttctc 2242801 acgataaaga tggtgacgcg cattatgatg tactgtccgc ttttcaaaaa tcaatccgcg 2242861 gctctgatgc caacgctgct cttcactatt tggctagatt aattgaagcc ggtgatctgg 2242921 agagcatcgc aagacgattg cttgttatcg cctatgagga tatcggttta gcaagcccgc 2242981 aagccggccc tagagtgctg aacgctattc agaccgctga gcgagtcggg tttcctgaag 2243041 cgcgaatccc gctggccaac gcagttattg agctttgcct ctcaccgaaa tcaaactctg 2243101 ccattctggc aatcgatgag gccctggcag atatcagagc cggaaaaatt ggggatgtcc 2243161 cgaagcattt aaaagacgcg cattataaag gagctcagga attaggaaga ggaatcgact 2243221 ataaataccc gcacaattac gacaacggtt gggtcgaaca acaatacctc cctgatcctc 2243281 tgaaaaataa gcaatactat aagccgaaac agactggaaa gttcgaatct gccttaaagc 2243341 aggtgtacga taaattaatg aaaagaaaat aaaacaaaaa aacagccttg atcatcaagg 2243401 ctgtttttat gcattattta tccttcacac gtttgatttc aatgtctttc aaaagatcca 2243461 tgacaacatg tccgcccata atcaaacctg caactgacgg cacaaaagca ttagaggaag 2243521 gcggcatttt tgctttacgt attttcgctt cgtcattccc cacttctttt ctgacatctt 2243581 cccgaataac aatcgggctt tcatcagaga aaatcacttg aacgcctttt ttgataccct 2243641 ccttgcgtaa tttcgtacga acgaccttcg caattggatc agtgtgcgtt tttgagatat 2243701 cagcgatttg gaagcgtgtc ggatccgttt tatttgcagc acccatgctg gagatgagcg 2243761 gaatatcccg ttttagacat tctttcatta aatgaatttt ataacaaatg gtgtctgacg 2243821 catcaatgac atagtcaaga ccatagtcaa aaaactgctc atacgtttcc tccgtataga 2243881 acatttttaa cgcgatcact tcacactccg ggttaatgtc tgcgatccgc gccttcatta 2243941 aatcaacttt cggctgtccg acagttgaaa gcagcgcgtg aagctgacga tttacatttg 2244001 taatgtcgac atcatctttg tcgacaagca gaatgcggcc gacgcctgac cgcgcgagag 2244061 cttccgccgc gaacgacccg actcccccga ctccaagcac agcaactgtg ctgtttttca 2244121 gcgtttcaag gccttctttt ccgatagcta attcattgcg tgaaaactgg tgtaacaaga 2244181 acctcactcc acattcgtat tctggtttca tctataaaat ggctgatcca tgagcagccg 2244241 ttttttctgc gcacaaaaaa taaagtccca atagtgccgt tgcagctttc ctttgttttg 2244301 aacccgctct cagcaggtgg gtgccctctt ttaaatcttg taagtcctct ttaccgaatg 2244361 aaaagaggca tgtacgccat ttaaaaatgc gggctcccaa atcaaaaaaa tgttcggtca 2244421 aaactaggtg tacaactaac acatcaggac tttatttaac ttgtcaaaat catatcacag 2244481 acgattttga ttttcaagaa tcgaactgca aattcagttc ttaacttttt tcttgataga 2244541 aagatgaagc tcgtcaagct gggcgtcgct tacttcgcct ggcgcttctg tcatcaggca 2244601 gcttgcactt gccgttttcg ggaatgcaat cgtatctctc aggttcgtac gtccagcgag 2244661 aagcataacg agacggtcta agccgagtgc gattccgccg tgcggaggag cgccgtattc 2244721 aaatgcttcc agcaggaatc cgaactgttc agccgcttct tctggtgaga agccgagaag 2244781 cgcaaacatt ttttcctgaa tatccttttc gaaaatacgg attgaaccgc cgccaagctc 2244841 atagccgttt aagacgaggt cataagcttg cgctttcatg tcttcaggcg ctgtttcaat 2244901 cagctcaagg tcttctcgga caggcattgt gaacggatgg tgcgctgcgt aaaaacggcc 2244961 ttcttccgga tcatgctcta atagcggcca gtcgatgacc cataagaaat tgaacaattt 2245021 ttcgtcaatc agtccgcgtt ctttcccaag ctttaagcgc agggcgccga gtgatgcggc 2245081 cacaacttcg aattgatccg ctccgaacag cagcaaatca ccttcagcag catcaagtgc 2245141 ttcaatcagc ttagactgct tttcttcatc aaagaattta gcgatcgggc ctttcactcc 2245201 gtctgcctca accttcaccc aggcaagccc ttttgccccg tagtttgcag caaaagcgcc 2245261 aagagcgtcg atgtcttttc tggagtaatc gccggcaccg ccttttacat tgatggcttt 2245321 gaccacgccg ccgtttgcta cagctgatga gaacacttta aattccgtat cctttacaat 2245381 gtcagacaca tccgtcaaaa gcatgtcaaa acgcgtatcc ggtttatcag acccgtactt 2245441 gttcattgct tcgtcatacg tcattcgagg aagaggaagc tgaagttcct caccttttgt 2245501 ttcacgcata acctttgcca tcatctcctc agccaatgac ataatgtctt cctggctcat 2245561 aaaggacatt tcaatatcaa tttgcgtaaa ctcaggctga cggtccgcac gcaagtcttc 2245621 atcgcggaaa cagcgggcaa tttgataata tcgttcaatg cctgatacca tcagaagctg 2245681 tttaaatagc tgcggagact gcggcagcgc gtagaactca ccttcgtgca cacggctcgg 2245741 caccaagtag tcacgtgcgc cttcaggcgt gcttcctgtt aaaatcggcg tttcaatatc 2245801 aagaaaccca ttttcatcta aaaagctgcg aacagctttc gtcacgttat ggcgcagctg 2245861 catcgtctgg aacatagccg gtctgcgcaa atctaagtaa cggtgtttta aacgaacgtc 2245921 ctctgacact tcttcagctt gatcagaaat cgcaaatgga ggtgtctttg cagcatttaa 2245981 tacgttcact ccatcagcat gtatttcgat cgcgcctgtt ttcaaattcg gattaactgt 2246041 tccctcttca cgcgccacca cttttccttg aatatcaagc acgtattcat ttctgatgcc 2246101 ttccgcaata gcaagcgctt cttttgacac atcagggtta aaaacgactt gaacaatgcc 2246161 cgtacggtca cgcaagtcaa taaaaatcaa tccgccgagg tctcgtcttt tttggaccca 2246221 gcctttcagc gttacagatt cgccaattgc tttttcagtt atatcaccgc aataatatgt 2246281 tcttccaaac aatgcgtttc actccttatc ccttttggtt tgccttcatc acatgtataa 2246341 attcatcaag tgccacttca atctgttcgc ccgtctgtgc atcctttaca ttgattttgt 2246401 tttgggcaag ctcatcttca cccaaaatcg caataaatct ggcctttaag cgatcagctg 2246461 ttttaaactg gcctttcatt ttcttatttt cataatcgat ttcactggaa atgcctgctt 2246521 ctctcagttt gtacaccaat gaaacagaat aatcctttgc tttttcgccg agtgtgacga 2246581 tatagcagtc gattccctta tcaacaggca gctctctttt ttcagcatca attgcggcaa 2246641 gcaagcgttc gatgctcatc gcaaatccga tgcccggtgc ttcaggtccg ccgatctgtt 2246701 cgacaagccc gtcgtagcgt ccgccgccgg caagtgtcgt aatcgcgcca aagccctccg 2246761 cattgctcat aatttcaaat gcggtgtggt tgtaataatc cagccctctc acaaggttcg 2246821 gatcgatttc atacgaaatg ccaagatcat ttaagtattg tttcactttt tcaaaataag 2246881 cggctgattc ttcatttaaa tatgtcaaaa tcgaaggtgc cgatttcatc agctcatgat 2246941 cacggtcttt tttgcagtcc aaaattctaa gcgggttcgt gtgcagccgg gactggcagt 2247001 ctgaacaaaa ttcttcgatg cgaggctcga agtgtttcac gagcgcttct ctgtagcttt 2247061 tgcggctatc ttgatcgccg agactgttta tgacaagctt aacgttttct aaacctgctt 2247121 tttcataaat actcatcgca agcgccatta cttcagcgtc gattgcaggg tctttcgaac 2247181 caatcgcttc aattccaaac tgataaaact ggcggtaacg gcccgtctga ggacgttcat 2247241 aacggaacat cggcccgaca taataaagct ttgtcggctg tacaggattt gcgaacagct 2247301 tgttttcatt aaaagcgcga accgcagcag ctgttccctc cggacgaagc gtcaggcttc 2247361 tgcctttgcg gtcctcgaag gtatacattt ctttttgtac gatatccgtt gattctccga 2247421 cgcctctggc aaacagttct gtatgctcaa aaatcggtgt gcggatttct ttatattgat 2247481 aagtgcggca agtgtctctc ataatttgtt caacaaactg ccagcgatct gattctccag 2247541 gcagaatatc ctgtgttcct ctcggaatgt tatatcccat aggtagacct ccttatgtat 2247601 tccttataaa atatccaatg atcgttaatg atgaaaatga aaaaaactcc cgcccctact 2247661 atacatgata gtagggacga gagttatacc cgtggtgcca ccctagttgg aatacgttca 2247721 tattcccgct cgatccttta acgcaggttc acgttcactg cctaatggcg ttattcacgc 2247781 gttcagcagg aaacctccgg agtgttgttt cgagaaagac gcaatgggat ccgctttcag 2247841 cctggggcgg gttcctctct aatcatgcaa tctgacctac tcttctccat tattggttca 2247901 aatctttcat catttgctat gtactcaatt tctattataa taatgggatt ggggttctct 2247961 gtcaagcttt attccggttg tttttcctca gcgctgcttc tttggacata agaccaaatt 2248021 cagatgctgt ttccgtaaga taaccagtcg tatcgggatc tgcgtgatcg ctgtaatgca 2248081 gattcgcttc accgtcgtga aatgcacgtc ccatttttgg atgatatttc atgatttgca 2248141 cacctttttg attgtattta cgcttagtat aaacaaatca ttttattttt atttaaaaat 2248201 cagaaaggac tttacgatat taaacaagaa tgctttttta atgatcatca gaaaggagga 2248261 cacaatgaac aagaaatact ttgtccttat tgtatgtatt attttcacct cagcgctatt 2248321 cccgaccttt tcatccgtta cagctgctca aggagaagcg gtcatcgcaa cagatgaaat 2248381 gaacgtcaga agcggcccag ggcttagcta cggcattaca gcggaagtaa aaaagggaga 2248441 acgctatcca attttaaagg aagatggaga ctgggtgcag atacagcttg gttctggaga 2248501 aaagggctgg gtagtctcct ggcttattac aaaggaagac caggccagca caagctcctc 2248561 aggaagcagt gacactgtga catcaacaga ccccgatctg cggatgagaa gcggcccggg 2248621 cacttcctac gaagtcatcg gcaaattccc gcaaggcagc caagcatctg tcattgataa 2248681 agattcgggc tggatcaaga tatcctatca cagtgccacc ggatgggtat catctgaata 2248741 tgtcacatca ggaggcagca gttcagcgtc tgatgagagt gaccaaaccg aggattccgg 2248801 tgcgtcaacg acgggcacag tcggtgtttc ttcgctaaat gtaagagcct ccgcctcaca 2248861 tgacgcggca attataacaa aacttgatcg cggaacgaaa ctgacggttc tcaacgagaa 2248921 aaatggctgg gctcacattg aggtgaacgg gctaaaaggc tgggttgcaa gccattacct 2248981 tttgactagt tctgttccag ctgatgattc agcaaatgcc ggcagttcat cctccgctaa 2249041 aaaagcctat atcatgtacg gaggaacgaa tctaagaagt gatgcgtcaa catcagcttc 2249101 gatcgttgag cgcgctgcca aaggagattc atacaccatt accggttcaa agggaagctg 2249161 gtatgaaata aagcttgata acgggcagac tgcttatgta gccaattggg tggtccaaac 2249221 gtctaaaagc gcagaagaag caggtgaacc gccagtctct gattccccgt ctggaaacgg 2249281 ctctctaaac aataaaacga ttattgttga cccgggacat ggaggaaaag acagcggaac 2249341 gatcgggtat tcggggaaat tcgagaaaaa cctgacgatc aaaacggcaa aactgctcgc 2249401 cagcaaactt agatcggctg gagcggatgt atatgtgaca cgccaggatg atacctttgt 2249461 cagcctgcag tcacgggtct ctacctctca ctaccgtaac gctgacgcct ttatcagcat 2249521 tcattatgac agctatgcgg atacctctac aagaggcagt acagcatatt actacagtcc 2249581 tgccaaagat caggaactcg catcagatgt ccactcagaa gtggtgaagc gttcttccat 2249641 tccagaccgc ggcgtattat tcggagatta ttatgtgctc cgggaaaaca gacagcccgc 2249701 tatgctgtac gagctgggat atgtaagcca tccgcaggaa gaagccattg tacatagcaa 2249761 ttcataccaa gaaaaagtaa cagatgggat cgaaagcgga ttagagaaat acttccaata 2249821 aaaaaagctg ccttttggca gcttttttta ttttgaatcc ataatgagcg tgaccggtcc 2249881 ggagtttgta agctgaacat ccatcattgc tccaaacgtt ccggtctcca ctttgattcc 2249941 tttttcacga agcaggtcat tccatttttc ataaagacct aaagctttat caggtttggc 2250001 cgcgttcatg tagttcggcc ggcgcccttt tttcgtatct ccataaagcg taaactgtga 2250061 gacggataaa atctctcctc ctatatctac aagagacaga ttcattttcc cttcactgtc 2250121 atcgaaaata cggagattga caactttatc ggctaaataa gctgcatcat cttctgtatc 2250181 atcgtgagtg atgccgacca gcaccataag gccttgtcca atttggccga cgacctcttc 2250241 gtccactgta acgcttgctt ctgttactcg ctgaacaact aatctctttt ctaacccctt 2250301 tagttcatga cgcggcgcac agaatagata tctctaatct gtttaatacg ctcgacgact 2250361 ttatgcaagt gattgatatt ctggataaaa atcgccatat ggatggttgc cactttattg 2250421 cgatccgatt tgccagagac agatgaaata ttggttttcg tttcattcac tgcctggagt 2250481 acctcgttca gcaatccgcg gcggtcatac ccaagaatct ctatctcaac attgtattcc 2250541 ttgcgctttt gaacttgtga ctcatgttcc cactctaccg ggatcagccg ctcttgggct 2250601 tcattcgttt tgacattcgg acagtcttcg cgatggaccg aaacccctct gccttttgtg 2250661 ataaagccga caatatcatc acctggcaca ggattgcagc attttgataa acggacaagg 2250721 aggttgtcaa tgcccttgac acgaacgcca gcttcccgtt ttcttccttg cgggtatggc 2250781 ttaggttccc cagtgacttc ctgaacgatc ttttcctgtt cttcctggtc gcgctgcttt 2250841 ctctcttttt ctgttaggcg gttcgccacc tgcagagctg tgatgccgtt gtaaccgacc 2250901 gccgcgtaca tatcctcttc atttgagaaa ttaaatttgt cagcaacctt ttgaatattc 2250961 tccggcgtta aaacatcctt caattcaaaa tccaagtttt taatttcttt ttcgaccagc 2251021 tcacggcctt tttcgacatt ttcttcacgc cgctgtttct taaagaattg acggatttta 2251081 tgcttcgctt gggatgtttg ggcaagcttc acccaatcct ggctcggacc gtaggaatgc 2251141 ttagaggtga gaatttcaac gatatcacct gtccgaagct tatggtcaag cgtaaccatt 2251201 tttccgttta ctttggcacc gattgtttta ttgccgattt cagagtgaat ccggtaagaa 2251261 aagtcaatcg gaacagaacc ggacggaagc tcgattacat ctccttttgg cgtaaagaca 2251321 tacaccatgt cagagaacaa atcaattttg agcgattcca taaattcttc tgcatctgtc 2251381 gattcatttt gaaattctaa aatttcacgg aaccaagaaa gctttttctc aaaggttgca 2251441 ccttcattgg ctgctttccc ttctttataa gcccagtgag ccgcaacccc gtattccgct 2251501 atttcatgca tttcaaaggt gcggatctgc acttcaagcg gatcgccttt aggcccaata 2251561 accgttgtat gaagcgattg atacatattc ggcttcggca ttgcgatata atctttgaat 2251621 ctgcctggca tcggtttcca gcatgtgtga atgatgccaa gcaccgcgta gcagtccttt 2251681 atgctattca caagaatacg gacagccaac aaatcgtaaa tttcattgaa ttgcttattt 2251741 tgcagcacca tttttcgata aatgctgtaa atatgtttcg ggcgtcccga gaagtcagcc 2251801 ttgatattta cttcttcgac acgtttcttc acttcattga caacctcatc gacataaagc 2251861 tctcgttctg cacgtttctt cttcatgagg ttgacaattc tgtaatattg ctgagggttc 2251921 aaataacgga gcgccgtatc ttccaattcc cacttaattt ttgaaatccc gagacgatgc 2251981 gccaaaggag caaaaatttc cagcgtttca ttggagattc tccgctgttt ttcctgaggc 2252041 agatgtttca gtgtccgcat attgtgaaga cgatccgcca gcttgatcaa tatgaccctg 2252101 atatcttgag ccatagcgac aaacattttg cgatgatttt ccgcctgctg ttcctcttga 2252161 gatttatatt taattttgcc gagtttcgtt acgccgtcta caagcattgc cacttcttcg 2252221 gaaaatgctt ctttcaggtc atcgagcgtc acatctgtat cttccacgac atcgtgcaaa 2252281 aatccgcccg cgattgtgga agggtccatt tcaagatcaa cgagtatccc cgcaacctga 2252341 atcggatgaa taatatatgg ctcgcccgat ttgcggtatt gctcgcgatg agcatcttca 2252401 gcgtacagat atgctttttc gacaaatgcg atatgctcat cagatagata gctgcgtgct 2252461 ttatctataa cttgctcggc agtcaatact tgttcgttcg ccatggaatc acctttttta 2252521 aaatgtaaac tgtattgtag tttattatca agaaaaaaac gaaagatgta aagagcagaa 2252581 gttcaaatag ccaaatatta tataaaataa atgcaaaaca ataggaaaaa agcaccctga 2252641 catggagtgc tttttcgtta tgcggttatc cttagtattt catcaatgtt aagatgtcgt 2252701 aatcttcgag cttatttctg ccgtcaaggt aagaaagctc gattaagaaa gcgataccag 2252761 caacaacgcc gccaagttct tcaacaagtt tgattgtcgc ttcaattgtg ccgcctgtcg 2252821 caagcaggtc atctgtaata agcacacgct gaccaggctt aatcgcatct ttgtggatcg 2252881 ttaatacgtc ttttccgtat tccaagccat aatccacttt gattacttca cgaggcaact 2252941 tgccttcttt gcggaccggc gcaaaaccta cgccaagcgc gtaagcaacg ggacagccga 2253001 taataaagcc gcgcgcttca gggccaacga ccaaatcaat ttgcttttct ttcgcatatt 2253061 caacaatttg atctgtggca tagcggtata catcgccttt atccatcagt gtcgtaatat 2253121 ctttaaattg cacgccctct ttcgggtaat ccggtacaat tgttacgtat tgttttaaat 2253181 ccatctgttt tatgtcctcc tcgtactttc ataagcctct gaatcttgtt tcatcagctt 2253241 attcagccat tccttcagct cttcagcaga agaataattc agcttttgat ccagttccat 2253301 cagctgctgt ttcgcctgat atgtttgtga gtctgttaag tcgcgtttct ttgctccgct 2253361 cacaacagac agcacaccat tctctatttt aacaaaaccg agatcaaaaa acacctttgt 2253421 catgaaattg attgtttcaa cggaccagcc tttatgtttt gcaagctctg aaccgtgttt 2253481 tttcacgtca aaagcgcctc ttttcagcaa gaacgcataa taccatttaa agtggtctct 2253541 tgcgggaaaa gttgataaaa agtggtcctc atgattgaga aaaataaaat atatccgctc 2253601 gggcgccttt ccttccagca aacgtgcgag catgtccagc gaaggcggcg gatccagtaa 2253661 tacaatatat gcaccatcga ggtcaaacgc ctttgcttga tctttagaac tgatgacgtg 2253721 cacttctcgg cgaaggtctt cagtttgaag taatgttgtt gagtcttctt tgaaagagac 2253781 aatggcccgt ttagcagatg gaagggcgga aactgtgtct tcccacgtcc gttttcccct 2253841 taaatcaaac agctgccatt cagaaacagc ggcatccttt atcataagct gcggcttttt 2253901 tcgattgttc cattcgttga ttgacatctc accgacaatg gaaattcttg aacccggtac 2253961 gatgccttct tgaagctcgc ctttattaaa accgacgcaa tcaagctggg acgactcgtt 2254021 tctgatcgtc attttgacat gagttttatt tgcccctatc ttgcggacat cttccagtac 2254081 tgcattttct acgagaacgt gcggtttcgg gttcagcatg ccaaaaggag acagcatgtt 2254141 catttctgcg atgctttcaa ctgtaatgtc ttcgacgccg cagacaaggt cgacttcctg 2254201 tacgggaata aaatcctctt ccgtaagcgt attgtccgct atttcattca gcctgcttcg 2254261 caaatccggc acatcttcgg ctttcagcgt catccccgca gccattggat ggccgccgaa 2254321 atgaggaaga atatctctgc attcagaaag gctctcaaat aaattaaatc ctctgatgct 2254381 tcgggccgaa cctttagcga ttcccttttc ttcatcaata ccaagaacaa tggccggtcg 2254441 gtagaaacgg tccacaagct ttgaagccac aatcccgacg actcccgggt tccatccggc 2254501 tttggccacg acaattgcag tttgatcgag cccttgctgt tcaaccattt caatcgcttc 2254561 atccgtcatt ttgctgacca ttttttggcg ctctttgttc agctggtcaa tttctgcggc 2254621 aagctcttcc gcttcaaacg aatcctctga cataagcaaa tgaacagcgg gatccgcctg 2254681 ttcgattctt ccgacggcat tcagccttgg tgcgagctga aatccgactg tttcttcgtt 2254741 cgcttctccg atgtctccgc ctgacagctt aatcagctct tttaagccga gccgatttgt 2254801 ccgtcgaagc ctttcaagtc ctagtgttgc tattaatctg ttttcgtcat gcagcgggac 2254861 tagatcggca atggtgccga tagccgccag gtcaagcagt tcatcaggaa gttcacccaa 2254921 taaagcgtgg gcaagcttaa acgcgactcc aaccccggca agctctttaa acgggtaagt 2254981 gcagccaggc tgcttcgggt ggacgatcgc acggacatcc ggaagctccg gtcccggttc 2255041 atgatgatcg gtaatgatga catccagtcc gagttccttt gccaccttcg cttcatgcac 2255101 agcggcaatt cctgtatcaa ccgtaatgat caaagagaag ccccgttctt taatcgaacg 2255161 aaacgcctgt tcattaggtc catatccttc tttaaaacgg tcaggtatat aaaaatcaac 2255221 ttgagccgac agtttttgca gcgtgtgaag catcactgac gtacttgtaa ccccatcggc 2255281 gtcataatcg ccatatatca taatcttttc ttgttgtgaa atcgcctgtt ttattcgatc 2255341 tgccgcttct ttcatgcctt tcatttcaaa aggatcataa aaatcggcat cctttgtatg 2255401 taaaaacagc ctagcgcttt ctgccgtatc aaagcctctt tttacaagca gggacgcaac 2255461 aagaggtgtt atatgcaatt gttctgtgag tgatttgacc ttatcctgat ctggtcgctg 2255521 gatttcccat cgcatttttg acgctaacat aaattcaccc ctcaaccacc ctattatact 2255581 agagcaggct gaggggtttc aaataatatt cgaaaactag tcttttttct caatcatggc 2255641 tgatgcatcc tgtgtgtcag tctgatcagc aagatgagta tcctcttgtt tatgtattgc 2255701 tgttctattt tctttccgca aggtttttat ttcccgcttc aatttcatta cctgaaaaat 2255761 gccgacagaa aatacgatca gtgctcccat taaaactgag cccaaaataa caagaatgag 2255821 cggccattct gatcttccaa acaggtaatc aacttctacg gatcgaacat taatgactgc 2255881 gaaaatagcg acaattaagg tgaaaataag tgcgaaaata atggtccatt gtttattcat 2255941 tctcttttcc cccaaacttc ttattgaggt aactttccca atcaagactg gttttaaaca 2256001 tggcttaaca ctaggttaag ctccctttgc tgttaatttt tcccggatca gcctcttcag 2256061 tccggttccc tcaccggaaa tcacaagtgt atcgccttcg tcaatgactg tttcagagct 2256121 cggattcagt tgtttatcct gattcttttt aacaattgca atgaccgtca catgatattc 2256181 ctgacccaca ttcaaatcac caatcgtctg atgaatggca ggcgctcccg cctctgcttt 2256241 acaccactct ataatcaaat catcaagggc tgactcgacc tgttctaatg ctttcggttt 2256301 atatgccatt ccgccaagaa ttgcagacat ttgccttgct tcagcgtcat caaactgcac 2256361 ggaggcaaca cattcctcat ggtcgttttc gtcaaaatag taaagctctc tccgtccgtc 2256421 atgatgaatg ataattgaaa ttttatcacg gtttctagta atcatttcaa ctttttgtcc 2256481 tatgcccggc agctctgatt cgcgaaccct catatataaa ccctcctaca tatctgaaaa 2256541 ccagccataa acacttttaa caccatatat atgtttaaat gtaagcgtat gtcattatag 2256601 caaatgtcta ttttaagttc aatgaaactt caaaaaacag gctgccctgc agaggacagc 2256661 ctgatatttt ttattgcgcc gaatcttttt tcagttctct tcctttccat gcaagccaaa 2256721 tttgtgcggc aatgtataga gaagaataaa cgcctgttaa cagcccgacc aataaagcaa 2256781 ttgagaagtt agtaatagaa gatgctccaa agatcagcaa tgtcacaaca acaatcacaa 2256841 cggttaatac agtgttaatt gaacgtgtaa aggtttgctg caggctcagg tttacaatat 2256901 ggttcagatc ggcaaaggtt ttcggcttac gctttttcat atgctcgcgg accctgtcaa 2256961 atgtaacgat tgtatcgtta atggaatacc cgattatcgt caagatggcc gcgatgaatg 2257021 taacatctac ctcaagcctt gtaatactga agaacgtgac gataaagaat gcgtcatata 2257081 gcaatgaggc gatggcagca atcgccattt tgtattcgaa tcggattgaa acgtaaataa 2257141 tgatgccaat agaagctata gcaactgcgt acagcgcatt tctcgccagc tccttaccga 2257201 ctgtcggtga aactgtgctg acatttggat cagatccgta tttgtcttta aaatacgttt 2257261 ttacttttgc aatggtttct ttatctggca ccccgacaaa acgggcaaca ccgatattgc 2257321 tcttttcgcc tgacagaact acagtatcag ggtccatacc cagagattca aaatccttct 2257381 caacttgctc tgtcgtcagc ttatggtcgc tttgcacttc aatccgtgca ccgcttgcaa 2257441 agtcaatgcc aagattcagc ctgaacacaa gcaggataat aatcccggca accgtgaccg 2257501 cactggagaa aataaagaag tatttgcgtt tgctcgtgaa atcccatttt tggaatggcg 2257561 tatgcggctc tgtattttca tccgtatcct gaatatccat gatatgtttc ttattgacac 2257621 caaaccagcc ttttttccga tcaagccatc tgctttccac aaggagagcg aggagaaatc 2257681 tcgataagaa aacggcagtg ataaagcttg tcaaaatcga taggatcagc attgtcgcaa 2257741 accctttaac agagcttgtc ccaaagataa agagcacaac cgctgcaata atggttgtaa 2257801 tattcgcgtc aaaaatcgtc gcaaatgacc gtctgtttcc tgaacggaag gcagagcgga 2257861 ctgactttcc tagcttgagc tcttctttaa tccgctcata ggtaataatg ttggcgtcaa 2257921 cagccatccc gacacctaaa atgagagcgg caattcccgg aagcgtgagt acggcattca 2257981 tccagtcaaa gatctggagt gtaatgtaga tataaacaga cagcgtaatc accgcgatta 2258041 atcccggcag acggtaatag aaaagcataa ataagaaaat aattgcgata ccgacaatac 2258101 cggcaaacac cgtatcatgg agagcctgct ggccgaattg cgcgcctact gatgtcgaat 2258161 acttttcagt cagtttcaca ggaagtgcgc ctgcgtttaa aatgctggct aaatctttcg 2258221 cttcttgagc tgtgaaatga ccttcaattt ttacatcagt tgtatttagt tcctgactta 2258281 catttggagc ggatacaaat ttaggatgct ctttttgaac ttctttctta aaggaatcac 2258341 ctttatcata atccaaccaa atgacaagct ggttgtttgg cgccattttc atgaccttct 2258401 tggtcacttc accaaattta tcagcgtctt tcagcttaat cgtgacaatt ggctcatttg 2258461 ttgtgctatc ataagtttgt ttagcgccgt tttcgactag atcagcaccg tttaacagtt 2258521 ccttatcatt tgcatctctg aaagaaagct gcgcttcagt cgccaaaatt tcacgcgctc 2258581 tgttttggtt tgtcacgcca gcgagctgaa cgcgaatccg gttattccct tcaatttgga 2258641 tgttcggttc gctgacaccg agaacattgg cccggcggtt cagtgcctct actgtgctga 2258701 ccagaacgtc ttttgtgatt ttgtcacctt tttttacagg ctgtacatca tacagcacct 2258761 caaatccgcc ttgcaaatcc aatcctaacg taatattgtt agcggcaggc ttcgtaaagt 2258821 agcccaagcc cgtgccgatc aatagaacga aaaggaaaaa cgcaatcaag cgtccttttt 2258881 tcattatgta tatcctccct taaacctgtg cgaatcaacc tgctatctca gcagttcttc 2258941 caatgcttcc tggccctctt cactgcccag ccaattagac gttttaaatg actcaacggt 2259001 tgcatagttc ataaattcgc caattttcac tgataaaata tcactcgcca gttcataaat 2259061 gctcagttcc gttttctttt tccacttctt atctgttaag tatgaccaca aactttcgag 2259121 ttcaacatca tcatacccga gaatcttaaa ctcttccagt ttgctgtaaa gaaacggcct 2259181 gacgtggtct ttatatagat cggctggatg cttctccacg aattccacgc tcctttttta 2259241 ttgtttttca agaagacttg tcatgcttgg acgacatata cgcatatctt tattgtatat 2259301 gattccaggt agtttgagaa ggcagggggt aaaaatggcg aaacagacgt ttttaaaggg 2259361 cactcttatc cttatcgcag caggaatggt tacaagaatg ctcgggtttg tcaaccgggt 2259421 ggttatcgcc cgttttatcg gtgaagaagg agtcgggctt tacatgatgg cagcgcctac 2259481 tttcttcttg gccactacat taactcaatt cggtctgccg gtcgcgatca gcaagctagt 2259541 cgctgaagcc agtgcgcgcg gagatcatca aaaaacgaaa aatattttag tcatgtctct 2259601 gaccattacg ggagtgctca gcctcatctt tacaccgctg tttctgtttt tcgcccctgt 2259661 tatggctgaa acgatgctga cagataagcg aacactgtat ccgctcttgg ccattacgcc 2259721 tgttgtgccg attattgcta tatcgagtgt gctgagggga tactttcaag gaaaacagaa 2259781 tatgaacccg cttgctatgt cacaagtcct tgaacaggtt gtccgcattt cactcgtggc 2259841 tgtctgcaca acgatttttc tcccttacgg aattgaatat gctgcagcgg gggcaatgct 2259901 atcctcagtg gcaggggagc tggcatcact tctttattta ttcgtttgct ttaagtataa 2259961 aaagacaatt aaaatcagaa agcatttttt acagtcaatt aaaaacggaa aacaaacctt 2260021 tacccaatta atgagcgtgt cccttccaac aaccgggagc cgctttatcg gaaacctctc 2260081 ttggtttttc gagccaatcg tcgtcgctca aagccttgcc atcgccggtg tggcaacagt 2260141 tgccgcaaca aagcaatacg gggaactaac cggctttgcc atgacgctgc tgactctgcc 2260201 cagctttatt acatattctt tgtcgaccgc gcttgttcct gcgatcagtg aaggaatgga 2260261 gcagaaaaaa ttgcaggtgg tggaataccg cttagaacag gcgatgcgtc tctgtctgct 2260321 cagcggaggc atttcagttg ttattttatt tgtatttgcg gatgagctga tgagagtgat 2260381 gtacggttcc tcaggcgcag ctgtatttat aaaagtgatg gccccgtttt ttctgcttta 2260441 ttatttccaa ggcccgcttc aagctgtgct gcaggcgctt aatttggcag gagctgcgat 2260501 gatgaacagc ttaatcggag cgcttgtcaa aacaggcctt atttttgtcc ttgccacaag 2260561 gccttctctt ggcattatgg gcgcggcatt agccattgtg acaggcatgg tgctcgtcac 2260621 gctattgcac gcagcaaccg taagcaaagt gctgccgatc agcatcaaaa tcaaggagta 2260681 cgcgctcagc ttcgctgtta ttgtaatttg cggattcatc agctccgcca tcaaacaata 2260741 tataagcttt ggagcatctg aggctgtcaa tctagccgga tggattgcgg cgagcgccgc 2260801 catttatatg atcctcctgc tcgttttccg tttaattaaa aaagatgagc ttcgccgcat 2260861 tcccattatc ggacggttga tcatccgata atggtcacgt gcggtgccca tctttttcat 2260921 caatatatat ttctccgtct gtaaacgagc aaaatgaaat atctgaaggg tttgtgtatc 2260981 cgtgtttttg caaactttca agcagccatt ttctatcttt actgattctg gacaggtttt 2261041 ctgtttgaat gaagccgtct ataatgagcg gcatttcgag ctgccgatgc tctccgctgt 2261101 tttctttctt aacaatagtc agtttgcccg acggctctaa aatagcaaat gatacgtcag 2261161 ctactctgtc gatgctattt tctctgagct gaaccattaa atcatcaaaa ttataacgct 2261221 gtgatttcat ggcttcttcg tcaatttttc catatttgat aattatggtc ggcttaccgt 2261281 caagaagctg gcggactttt cggtttttta aagaaaagta tgccaaagtc acttgaatga 2261341 tcattaatac aagcattggc aaaatggtat gaaatagatg atcgtctacg ttttctatgg 2261401 ctaaaacggc aatttcagcc atcatgataa agacaacgag atctaaaata ctaagctctc 2261461 cgatctcccg tttgcccatg aaacgaaaaa tgaccaatat cacaaaatac aatacgactg 2261521 tgcgaaacgc aatagtgaga agctcttcca ttatgcacct ccaactcatt ataggttgca 2261581 acaaaatgat caatttatgt aagaaaaacc gattgcattt cacaaagctt ttacgtctaa 2261641 ttcatgggat aagggaatac atttttacaa agacgagcca tcagcatgtc tgacggtttt 2261701 gaacaaaaag aacagaagcc ttttaataca ggcagagagg agacaatcat ggaggaaacg 2261761 aaacaagttg gaaaaggcat tctttacggc ttaatcgcca tattttcagc catgctcctg 2261821 acaagtttag cggtttcact tttattgacc gcaacctcgc tggaagaatc atcatttaac 2261881 tggctgatca ccgctatctc atttctctct ttatttatcg gcgggttcat ttcaggcggg 2261941 aaaggcaagg aaagaggctg gatgattggc gcattgaccg ccttaagttt ttctctgatt 2262001 atcttattgt ttcagtattt aggattcgga aagacattta cagcagaaca gctgatcttc 2262061 catctgggat ttttaggggt gtgcatgctg ggcgggattt tcggcgtgaa catgagggga 2262121 aacaggtctt ccacataaaa aagagcgggc tcacttgccc gctctttttt gtttgctatg 2262181 tatagctcct gctgttattc agcagcagaa acttctctga tcgcgcggcg gtcgaacgta 2262241 agacgtgtgt tatcaccagt cttaattacg actttgcttt cgtcgataga gtcaacagta 2262301 ccgtgcaatc ccccgattgt cactactgaa tcgccttttt tcagttcctc ttgcatttgg 2262361 cgtacagcct tttgctgctt ttgctgagga cgaatcagca agaagtaaag gaccgcaaac 2262421 attaaaataa taggaaccaa tgtacctaaa gtgccagtca tcattttcac ccctttctgt 2262481 aagcctgtta tgtttattta gaagcttttc gcatttggct tgttatagcc gtaacgctca 2262541 aagaactctt ctctgaaatc acccagacga tcctcgcgaa tagcctgtct tacctgctcc 2262601 attaagtgta acagaaaatg aaggttatgg taagttgtta atcgaaggcc gaatgtttca 2262661 ttgcagcgaa tcaagtgcct aatgtacgcg cgagtgtagt ttttacatgt atagcaatca 2262721 cactcttcat caatcggacg gaagtctctt tcaaatttcg catttttcat attgagtcgt 2262781 ccttcagcag taaacactgt gccgtttctt gcaatccgtg taggcagcac acagtcaaac 2262841 atatcgaccc cgcggatcgc tccgtcgatc agtgcgtccg gagaacctac tcccatcaga 2262901 tatctcggtt tatccttcgg caagagcggt gttgtgaatt cgagtacacg gttcatgaca 2262961 tccttcggtt cacctacaga caatccgcct atagcatatc ccggaaaatc aagcgaaatc 2263021 aagtccttcg cactttgtgt ccgcagatct tcatattctc cgccttgtac aataccaaac 2263081 agcccttgtt catcctgacg attgtgggca ttcaggcagc gttccgccca gcggcttgtc 2263141 cgttcaactg acctcttcat gtagtcgtac tccgccgggt atggcgggca ttcgtcaaac 2263201 gccatcataa tatcagagcc gagtgcgttt tggatctcca tcgctttttc cggagataaa 2263261 aacagcttgt ctccatttag atgattgcgg aaatggacac cctcttcctc tatattacga 2263321 aacttgctta aagaaaagac ctgaaaaccg cctgaatctg ttaaaattgc gcggtcccag 2263381 ttcataaatt tatggagccc gcccgcttct ttgacaatgt cttggcccgg acgaagccat 2263441 agatgataag tgttgctcaa aatgatgcct gcatccattg ctttcagctc ttcaggcgac 2263501 attgttttga ctgtcgccag tgtgccgacc ggcataaaaa ccggcgtttc gaaggagccg 2263561 tgaggcgtat gcactttgcc cagccgcgct cctgtttgtt tgcattcttt tataaattca 2263621 tagcgtattg gttgttcagc cacttttgat gaggcctcct gttctcaaat tatataatca 2263681 gcatcgcgtc tccgaagctg aagaaacggt attcctcttc cactgcatgg ttataggcac 2263741 gcagaatgtt ttctcttcca gcaagcgcgc tgaccagcat aatcaatgac gatttcggca 2263801 aatggaagtt tgtaatcatt ccgtcaatgg ctttaaattc atagcccgga taaataaaaa 2263861 tagatgtcca gccgcttgat gctttaaatt gcccgtcatg ttctccggca atcgtctcaa 2263921 gcgtgcgtgt cgaggtcgtg ccgacagaaa tgatccgacc gccattttct cttactttgt 2263981 ttaaggctgc agccgtttct tctgacattt gataaaactc tgcatgcata ttatgctctt 2264041 ccacttcatc ggcactcaca gggcgaaacg ttccaaggcc tacgtgcagt gtgatgaact 2264101 caatttgcac gcctttgtct ttcagctgct gtaagatttc ttccgtgaag tgaaggccag 2264161 ctgtaggcgc agcagcagag ccaatttctt ttgaatacac tgtctggtag cgctctttgt 2264221 catcaagctg ttctttgata tatggaggga gcggcatctc tccaagggat tcaagcacct 2264281 cgtagaaaat accgtcatat tgaaattcca tctttctgcc gccgtgctca agctcttccg 2264341 tgcagattgc cttcaatctt ccgtctccaa atgtgacaac agttcctttt ttcacccgtt 2264401 tcgccggttt ggcaagtgtt tcccatttat caccggtttc ctgtttcaac aaaagaagtt 2264461 ccactttcgc gccggtatcc tcttttgtgc cgaataaccg cgcaggcagt acccgggtat 2264521 tgttcaggac tagacaatcg ccttcgttaa agaagctgat aatgtgttta aacgagctgt 2264581 cagtaagctc tcctgtatgt ttatcgagca ccatcagcct tgaagcatca cgctgctcca 2264641 acggtacttg tgcaattaaa cgttctggta gttcaaaatc aaataaatcg actttcatga 2264701 tgatttcacc tttattctag tcttttgtta tttcattctg ccaaaaagat taagcaaaat 2264761 tgataatacc acacttataa taatacaagt gacaaccggg aagaaaaacg taacatttcc 2264821 tttttttaca aaaatatctc ccggcatctt gccgacaaaa tgcaaaactg ctccgataat 2264881 aagcaaaaca gcaccaagaa tcataatgat cttaggaaat tcagtcatat cggggagcct 2264941 ccatttggaa atgatgataa acggccggtg tcacgatcct tccacgcggc gttctttgta 2265001 taaatccaat ttgcagcaga tatggttcat atacgtcttc aatcgtatgc gattcctcgc 2265061 cgatggtagc tgaaatcgta tcaaggccta ctgggccgcc gttgaatttt tcgatcatgc 2265121 ccatcagcag cttatgatca atatgatcca aaccgaggcg gtcaacctga agccgctcca 2265181 gcgcattctg agaaatgtct tccgtaatcc tgctgtcacc cagcacttgg gcgaaatcgc 2265241 gcacccttct cagcaggcgg ttcgccacgc ggggcgtccc tctcgatctt cttgcaattt 2265301 caagagccga cggtttatca atctcaacct cgaatacatc agcggttctt gtgacaatat 2265361 ccgccagttc ttcttgtgta tagtactcaa ggcgagacat tacgccgaat ctgtctctta 2265421 aaggagccgt caaaagcccc accctcgtcg tggctcccac cagcgtaaaa ggcggaaggt 2265481 cgaggcgaac cgagcgggca gatgggcctt tgccaatcac aatgtccagg caaaagtctt 2265541 ccattgcagg ataaagcacc tcttcgatcg atctgtgcag cctatgtatt tcatcaataa 2265601 ataatacatc tcccggttcc agcgccgtta atatagcagc caaatcacca ggcctttcaa 2265661 tcgcaggccc tgatgtcgtc cgcaattcca ctcccatttc attagcaaca atcgaagcaa 2265721 gcgttgtttt tccgagtccg ggcggcccgt acagaagaac atgatccagc gtctcctgtc 2265781 tcattttcgc cgcatctata aacacgcgca aattttcttt taccttatgc tgcccgatat 2265841 actgtgccag attttgcggc ctcaggcttt gctctatcac tgattcatgg ttgtctgctt 2265901 cacttgagac gagccgttca tccatgaaca tcaccttact ttaatagttt ttgtaatgct 2265961 tttttcacat attggtctgt tgtcagccca atttcttctt taaggtgagg aagcaccttt 2266021 ttgatttctt tttcagcata tccgagaacc ctgagggctt caagtgcttc ttcaagagcc 2266081 gtttccgctg tttgcttttc aagcctttct tcatgattaa acagattttc aatcatttca 2266141 ggcacaacat ctgccagctt tccttttaaa tctagaataa tctggcgtgc ggttttcttt 2266201 cctactccag gaaacttgac caaaaaagct tcatcttcat tttcaattgc ttggatgacc 2266261 gctccgggat cacccgagcc caagatggca agtgctcctt tcgggccaat tccggtcacg 2266321 tttaacagct ttgtaaagag cgccttctcc tctcttgttg aaaaaccata aagcgaaaaa 2266381 gcatcctctc tgatatgatg gtatgtaaaa atcgtttctt ggcttctctc cttatatata 2266441 aacggattcg gcgtgaaaat ctgatagccg atgccgccgt tctctatgac aatatattgg 2266501 ggagatacat aatcaatcgt ccctttaaca aattcaatca cgcaaattca cctctttgac 2266561 tgttcttcat tgtaccataa aaacagccaa agtcttatag aaaagttaac atatgttcgc 2266621 ttctctctca ttctttcacg aaaaaaaaga catgaataca tgtcttcaat cagcggacgc 2266681 tacccgctgt atgtcttcat atgttcgatg acatcctcaa actccgcttt tgtccgaaat 2266741 ggaatgcctt tcagcagatt tttttgcata tggctttcca gcctttctaa atcaatttga 2266801 aaaaaagact gaattggttc ggaagctggc tcaggccgcc catgaaaagt ggaaatcact 2266861 ccattatccg atacaccgat atacccgttg accttgctga gcggagaaat atcgtccatt 2266921 tgcttccgga agagcacata tccctttttt tgttccacta gcgtccatcc ggcataagct 2266981 gcccaaaaat catccataga aaacactttt tcatgcttat gctcaatgct gacatcgccg 2267041 tccaaataca ccttttcaag ctgcacatgc acctgcagcg gctcatagtg ctccacttcc 2267101 gcgccaagtg cgcgggaagg agctcctatt aaaaatactg ccgctgagca aagaatgccc 2267161 agcaaaagat acgccgtgct gaatcgtttc accctctaca cctctttgca cacgtttatg 2267221 attagtttga ccaaagaggc tactgcttaa ccgttttatc aaaatttgtc tgcacatttt 2267281 ccctgacaaa ccgttcctcc gtatacacat ctgtgctttg ctcagaaatt gtcaagaatc 2267341 gcgtcagaaa ggcactgaaa aaatacaatg ccgcaaagat ccaaatcacg ccacctgcac 2267401 cgagcggccc aatgaaaaga ctcacgatgc ccggcgcgat aaacgcacat aaaccagatc 2267461 ccaaattcaa cactgacatg gcagcacctt tattatcagg tgcaagcgtc ggcaaaagcg 2267521 cgcttaatgg gacgtaccct gctaaagccg cgccgtagca gcaggcgata atcatgagca 2267581 cccaatactg atgcccgatc agctgaggcg tgtaatacag cgccagcgta aaaataccgc 2267641 atccgacacc gccaaaccac atgaccgtat tgcgccagcc tagtttatct ccgactgcac 2267701 cgaaaatgat attaaacaca atattcacaa aaaacagcgt cccccatatt tgcagccatt 2267761 ccgaaaccga atacccgtat cgtgctaaat aagtaggaag aaagatggca aatccaaatt 2267821 gtcctatcgc attaatcgtc ttgaccactc cgccgatgcc taccttaggg ttttcaaaca 2267881 taatcgtaaa tgccttcgac agttctttcc atttcggctg atcttgtttt tgtatcggag 2267941 taaatttatc tttgttaaaa aataaggcaa gaattccgcc tgccgccaca aacagtaaag 2268001 cgctccaaag cgtattgatt tctccaaagg ccggaactgc atagctggaa tagaacggac 2268061 cgagcacgtt aaggccgcac gtaaacataa accaaaacca gccgacggct tttccaagaa 2268121 tattttgaga ggtgctgtat gacacccata cgagaaaaga gtatgcaaac agcggatatc 2268181 ccaagcctct aagagcatag ctgcccaaga gagccggata atacatatga ggaatcgccc 2268241 agccgataaa agcggccgaa ccgaggataa atgcaagcaa tccgacagtc atcgtttttc 2268301 tcggccccca agtttggaca aacgttcctg aaagccaagc tgagatggtg acagcaatgc 2268361 cgtacatggt aaataacgat gcggattgct gcatactgag accatgatca acgagaaaag 2268421 gagacagcca gccttgttcg aggccgtctc caaccataaa gatgacaacg ccaatataac 2268481 cccaaaccat gtgagaagga attccgattt tgttcaaaac atttccttta gcatgtactg 2268541 tattcatttt ctccaccgcc tacttaaagt atcaatggag tatataccca agcttgctga 2268601 attgtaatcc tgttagatta aaaagcgatt ttttcagtgt gctcaatgct aacaggcatg 2268661 ccaaaagcaa gcgattgctg tgctgctctg gcgatcctcc cggcctgtaa accgtcattg 2268721 ccggtgcagg gagtctcctg gtttgtgccg atcgcttctg caaaacggag aatctcctcc 2268781 tcatatgaat ccttatagcg ttcaaggaaa aagaaatgcg gtttatcctt catcacaaaa 2268841 tcagctgttg acacctcaac cgttgtcggc ctgctattgt cagccgctgc agagcctttc 2268901 gtcccgaaaa cctcaacccg ctggtcatat ccgtacacag cttggcggct gttatcaatc 2268961 acagccatgg caccgttttc aaaagtcagt gtaataacag ctgtatcaat atcacccagc 2269021 tccgcaaaag aaggattcac caaagccgcc cctttggcat acacttccgt cacttcgctt 2269081 cccataatat atctggccat atcaaaatca tggatcgaca tatccataaa caatccgcct 2269141 gacgtacgga cataatctat attcgggggt tctgggtccc gggacgtgat ttttaataaa 2269201 tgaggtgtac cgatttcacc attttcaaca atcgttttga ttttcttaaa atgaggatca 2269261 aagcggcggt taaatccgac ttgaagtgtt accccgtgtt tccggacagc cgcaagcgct 2269321 tcactcgttt cgtccagaga gaaactaacg ggcttctcac aaaatatatg ctttttcgcc 2269381 tcggctgctt ctttgatcat ctgtgcatgt acggctgtag gagagcaaat aaaaatagca 2269441 tcaatatcag gatcatgtaa taaatcacga taatcagagg ttatgtattc aatctgatga 2269501 ctgtcggccc agctttttat acggctcgcc tgaatgtcag agattgcttt tattttcatg 2269561 tgaggaatcc ggcttatatt ttgaacatga agtttgccga tgcggcctgc accgataatc 2269621 cctgtcacaa tctgttttgt catggcttct tcccccttga tcattcacga aagcgcttta 2269681 tttaaaatta atactatccc atttgtaagc gcttttcaag aatggaaatt aaacgttcta 2269741 tgtctctttt atcacaattc atgcttataa gtagccttct tcttcaagac cagatacact 2269801 agaattaggc tctttttcct gaacagttta tgattttcct ataaacagct gcataaaata 2269861 gagcaaagaa ggtgaatgaa atgctgacaa aagcagaggc actggcccat accgtcatat 2269921 accgcaagaa cagcagattt gataaagtca aagagaaatc cgaggaatta acactaatcg 2269981 gcaagggaag aagcgcctat gtgtttgcct taacagaagg cggtcgaaaa atggcgctga 2270041 aagtattttt tccggaatat caagcgacag cagtcaaaga agcagcgatc tatgaaaaat 2270101 tagccgggtc cgcattctat cctgacattt acgaaactgg cgattcattt attctcatgg 2270161 aatatattaa aggtgaaacc ttttataact gtctgaagaa aggcattgca atcagtgatg 2270221 acatgattca gcaggttgaa gaagcgcttt ctgacgcccg ggcagccgga ctgaacccgt 2270281 cagatattca tttgcggaat ctgatattga cagaaaccgg ggcggtgcgg gtgattgatg 2270341 ttgcgagatt tgagcagaca aaaacatgca cgcagtggga cgacttaaaa tccgcatatc 2270401 atgcactcta caaaaaaccg atattcccca aaaagattcc gggtttttgg ctggagatca 2270461 tcgcattttt atataagaaa gattggtttc aaaagcattt cgcacagcgg aaaagaaaat 2270521 attcttaaat caaaaaggca gccgcacaag cggctgcctt tatcatgtat tttttacttt 2270581 ctgacggcag aaatcagttt catttgttca ggcgacagct taattcgata gcctctcaca 2270641 gttaagtaga ccgcttctgg gtccttctcg ccggaatgac aatacgtttt ttccatttct 2270701 gtctcccctc accctttatt ggctttattt catcttatca ttgctttatt gaggtaattt 2270761 taaagaaatg taaagattat atgaatccga tatatagtaa aatgagagaa aaaaagggag 2270821 agagtcacat taagaccgaa aacaccttga gcttagatgc agccagaggt gaacttgtaa 2270881 atgaaaaaac acttgtcaag agaacaatct actggaatta cccggacagc cgcccagcag 2270941 tgacgtggat caatcacaat acagtgaaaa tcggcaatca gactttacat cttgatactg 2271001 atgaaacgta tgattggcga aaagatgatc attggatccg tgaagaaccg ccgcaggcgt 2271061 cagtgaggtg atgaaacatg aataagatga acggaacaaa tgatgaaaag catttcaatc 2271121 attttgtgat tgctttatcc tttatatacg gtttgactga actaggctat ttgttgctga 2271181 aggattttat aacaattgcc ataagtttgc ctctgtagaa aaacgcagcg tagtcgatac 2271241 gccgcgtttt ttctttttcc cttcctcttc ttattgataa ttacaggtca tataatgtga 2271301 caaatcgatt gtagaaatag ttcgattaga ccaaaatcct ttttatacat gtattcgaat 2271361 ttgaagtgag ggggaagctt gatggcagat tttgttgcta gtttgaatgc ggtcttatgg 2271421 agtacgcccg tcatttatat tttattggga attggattcg ccttttcaat tatgacccgt 2271481 tttttacaag tccgacattt aaaagaaatg attgttcaga tgttcaaagg caagagctct 2271541 gaagccggcg tttcatcttt ccaagcgtta tcgattgcgc tgtccggccg tgtgggcaca 2271601 ggaaacatcg cgggagtggc gacagcaatt gcattcggcg gacccggtgc agtgttctgg 2271661 atgtgggcga ttgcctttat cggggcggcg agtgcctttg tagaatcaac gcttgctcaa 2271721 atttacaaag tgaaacaaga cggtcaatat cggggcggcc ctgcttatta tatagaaaaa 2271781 ggcttaggca ttaagtggtt tgccgtctta tttgccgctg ctgcccttat tgcaatggcc 2271841 tttctaatgc cgggcgtaca gtccaactcc attgcggctg ggatccaaaa tgcattcggc 2271901 atctctcctt tcgtcacagg gtgcggtctg gttttattat tagggttcat tatttttggc 2271961 ggcgtcaaac gaattgccaa tgcggcgcaa atgattgttc catttatggc cattggatat 2272021 atcctgctgt ctttgattat tattgtcatg aatgtgtctg aattgcctgc tgtgatctca 2272081 ttaatattca aaagcgcctt cgcattggat tccgcttttg gcggcttgat cggtatggcg 2272141 atttcctggg gcgttaaacg tggcatttac tcaaacgaag ccggccaggg aacaggcccg 2272201 catccggcag ctgctgcaga ggtttctcat ccggtcaagc agggactggt tcaggcattt 2272261 tctgtttata ttgacacctt gtttgtatgt tccgctacag ctttcatgat cttgtttacc 2272321 ggcatgtaca atacccaggc tgcagatggt tcctttatcg ttcaccagct taaaggcgta 2272381 gaagcaggac ctggtttcac acaagcggca attgacagtg ttcttcccgg attcggtgca 2272441 ggctttgttg ccatcgcttt attcttcttc gcttttacaa caattatggc gtattactac 2272501 atcgcagaaa caaatatcgc ctatttagca cgaggcagag aaagcaaatg ggcgatgctt 2272561 ggcttaaaac tgattatttt agccgccacg ttctatggta ctgtgaaaac agcttcactt 2272621 gcttgggcat taggggatgc agggcttggc attatggtat ggctgaacgt cattgccatt 2272681 gtgctgcttg ccaagccggc gctccttgct ttaaaggatt atgagcgcca aaagaagcag 2272741 ggcttagacc cgatctttga tccaaaagcg ctgggtatca aaaacgctga tttctgggag 2272801 aaagaataca ctcatgaaag tgaacgtgtc tcctgaacat actaaaaccg gcccgatatg 2272861 acctcgtgcc ggttttttat gaacgatagt ttgtatacac ttcttgaaca tcatcgtcat 2272921 cttcaaggac gtctattaat gtttccagct tctcaacagc ctgatcatcg gcttctgcat 2272981 aggtattggg aagcatggtc acctccgccg aagaaattag atatttcgat tcgagggctg 2273041 ttttcacctc ttcaaaatgc tcaggctctg tgaaaacctc atataggtct tcttcaattc 2273101 gcagctcttc tcctcctgct tcaagcacat caagcatgag ctcatcttct tctatttgcc 2273161 gttcagtacg gtctatcgta atgaacccct ttcgttcaaa taaaaaggct acacatccgc 2273221 tttctcccag acttccgcca tttttattaa aggctgtccg cacatttgac gccgttcggt 2273281 ttttattatc tgttacgcat tcaaccatga cggcaatccc tgaagggccg tagccttcat 2273341 aggtgatttc ttcatagctg cttccgtctt ggcctcccgc agctttttta atggcccgat 2273401 ctatattttc attcggcata ttggcgcctt ttgctttttc gatgacaaga cgcaatgctg 2273461 aatttgcttc tggatccgct ccgccttctt tcgctgccac atagatttct tttgccagct 2273521 tcataaatat tttcccgcgc tttgcatcct gtgcattttt tcttttttga atgtttttcc 2273581 acttggaatg gcctgccatg ttttcacctt cttttacatt ttctatgtac actttaatgg 2273641 gaaatgttcg ctgatgcaaa gaaaaaggct gccgaatatc acttccggca gcccttcctt 2273701 cctagcggtt gttcatttta tgaagttttc tgaacagccc tttatctgtt gatacttgga 2273761 cgtcacggcc atttgcatag ttgcgcgctg cttttacaac attatctctg tcagactttg 2273821 tgaactctct gtggcttttg actgcgataa ctactcggtc atccgatacc ataacttgtg 2273881 tgtcattgac gtttttcact tgtttcacac ggttggcaat ttttgcagcc agtcttctgt 2273941 tttcttggtt gtcatacccg ttgttcgctg cattccgatt catgtttcgg ttattcgtgt 2274001 tgttatatgt tccgtcagtt gccaaaggaa cacgatcgtc agcagtaaca cggtcacggt 2274061 tatttacatt cgtggtgttt cggttaccgt cgttctgatc ctccattaat tcagaaacag 2274121 gaccatcgtg gtcgattccg tctccctgtc tatcggcgtc attttcattt gtataatatc 2274181 cgattggacg ggtattgccg ttattgcgcg tatcattcat agcattatcg tttgctccgc 2274241 atgctgttaa gccggctgtc attagaatca ggctagcgat cgtcattttt ttacccaatg 2274301 gaaaaacccc ccgtggacga attgagcatg tttgctcgct tttatcatgt gcgtatgggg 2274361 ggcatgttaa gcgtgtcagt tctctccatt tggcagtgat ctgcttgaaa acaaaaaaag 2274421 gaacgattta catcgttccg aacgatcact cattttcttc ttccggacgg ccaaacattt 2274481 ggtttacaga aggctggttc gtcattggca tagaaactcc tgccgaatat gggtttggat 2274541 ttgggttagc tgtgccatat ggcatattag ggcttccata agctcccatt cccgaatggc 2274601 caggtgcaga gaaatatggc tgatgatcac cgtcacagcc gcagtcgtca tgatctttgt 2274661 atggcatgta accatgagcc gcagcaggct ggtatgctcc cattacttgg ggagtgccgt 2274721 aataagggcc atacggcata tgtccatacg gagatccata agccggagat gcgtattgcg 2274781 gcgcaccgta tgaaccgtaa tgtccgtgat ggctgttttc atgatgctgg ttttcataac 2274841 ccgggtcata ctgaggcgat acaaagcctg gctggtatcc atgcatcgga tgcattggat 2274901 aagcttgtgc cggatagtac ggatagcata atcctgatcc tggaagaatt ggcgaaacag 2274961 gcaccggaca cggtacgaaa tgagccggat aatgataata aggctgaaca gccggcatcg 2275021 gcatattcgg aactgtgtga tgaacgtttt cctcttctat accgcctacc tctggcgcct 2275081 ttggcatatt aggcatattc ggataatttg cattttccat attactcata gcctcctgtt 2275141 gtggaaattg gtcttgcata tgatacatat gatccatatt tccgtcatga tgttttttcg 2275201 gctcctccgg tttaggaggc gaccaaggct ggaaaagctg tttcatatca taataatcgt 2275261 tcacatcagc ttcagggtac acattttcct gcaaattagg catcggcggg acatacggca 2275321 tggacttctt ttctttcggc tttgtgtctt ctacatcgac aacggattta ggcttctctt 2275381 tcgcatatgg atgttcttgc ttcacactcc cggccgcagg acttttgccc gcttttggct 2275441 cttttctgac cgggactcct tctgacggca cttttatttt cattccaggc atgattaagt 2275501 ctggattgct aagctgtgta ttgagttttt tcacttcctc aacatcgact ccgtactttt 2275561 cagctatttt ccagagcgaa tcgccttttt gaacgatatg gattttcaac gttttcccct 2275621 cctatgcaaa acgtgaacag ttcagctgtg attacaatat gtttcttcac aacatatgcc 2275681 tgaacaaaag aagttatgag taaaggaagg gaaaatattt ctgatctacg tgatcgaaag 2275741 cattcgattc agggcaagga gtgcatcttc ctgaatggct tttggcacct tgatgacgcc 2275801 tgaaggttct cctttttcaa tttgttccag cgaccacaac aaatgcggca aatcaattcg 2275861 gttcattgtc aggcaagggc acatgtcagg gttgagtgat tcgatttgtt tatctggatg 2275921 ctcgtgaatg atccgctgaa caagattcat ttctgtcccg attgcccact tgcttcccgc 2275981 cggagcctgg ttgattgtgt cgataatata tttcgttgat ccgttatcat cgcttagtgt 2276041 cacgacttcg tgtgaacatt ccgggtgcac aatgatctga atgtcggggt ctcgctctct 2276101 catatcatgg atatttttag tggtgaattt ctcgtgaaca gagcaatgcc ctttccacaa 2276161 aatcactttc acattcgtat gcccggattc agctactaat tcatctttca tcggatccca 2276221 cacagccata tcttcaagcg caatgcccag atcataagcc gtatttctcc ctaaatgctg 2276281 atcaggcaaa aataaaattc tttttttctg tgtaaacgcc cattcaagca cttttttcgc 2276341 attcgaagaa gttacagttg ctccgccatg ctttccgacg aatgccttga tctccgcagt 2276401 ggagttcaca taagttaaag gtatgatcgt atctccaaat atatgctgaa gcttcttcca 2276461 tgccctattg gtctgctgca tgtcagccat gtcagccata gaacatccag ctctcatatc 2276521 tggcaggacg accgtttgct gctcgcttgt cagcatatcg gcggtttctg ccataaagtg 2276581 aacgccgcaa aatacgatat aatccgcttc tttgtttttt tccgctactt gggccaattg 2276641 cagggagtcg cctgtttggt cagcaaattg tatcacttca tccttttgat aatgatggcc 2276701 tggtataaag agcctgctgc cgaacttttt cttaatggcg gcaacgcgcg tttccatatc 2276761 ctttctcgat agttctttat aactttcggg catcatatca ttcgattgtt tgatcacatc 2276821 aagaattgac ataacagcat tcctccacag attcatttga taacgtaaca tccatgctga 2276881 tatctaaact tttgacggaa tgagtcagaa atcctaatga aatataattc acacccgtcc 2276941 ctttaaaagc aggcaaagat tctaacgtaa tcccgccaga ggcttcagtt tttatattag 2277001 ccggtgtgag ctttgcaaaa tgacggaccg tatcaggcgg acagttgtca aacataataa 2277061 catccgctcc agctgcaatt gcttcccgca gctgttcctc cgtttcaatt tccacctcga 2277121 tatttaccat gtgccctgcg gcctgacggg cttttttgca cgcctctaaa atagagccgc 2277181 atgctgcgat atgattatct ttaatcatga tgccgtcata caaaccgaat cgatgattat 2277241 acccgccgcc ggctctgaca gcatatttct ccagcattct gagccccggt gttgtttttc 2277301 tcgtgtcaca aattttaatc tgttcatcat ccagacaccg aacagcctct cttgtcattg 2277361 tcgcaattcc tgacagcctc tgaataagat ttaatacgac ccgctctcct gaaaggagcg 2277421 cagctgcggg accgtgtaac tcggcaatca cttcaccttt atgcaacatg tccccatctt 2277481 ttttgtgtaa aatgctttga acattttcgt ccaataacga aaagccttct tttatgatcg 2277541 ctgctcctgc aaaaataccc tctgactttg caacaatctc cgcttcacag ctctgttctc 2277601 caaaaataga ctgcgatgta agatcccctg tcccaatatc ctcaagaaaa aagtgattca 2277661 gtaatttttt cagctgtaaa tgattcattg ttccaaatcc cctcgttttt tctgatcttc 2277721 gttccttttt ttgtatggac aatttgtctt ccttgccagc tcacctcagc atgaggaaaa 2277781 tcggtgcgga agtgagcccc tctgctttcc tcccgcaaaa gcgcagaaaa cgtcatcagc 2277841 tttgcagttt gccatagatg agaaagttcc atctgccgaa ttgtgatatc cttcacattt 2277901 acttcctgaa aaggcagcgt atgaagccag atgctaagct caatcaaact gctttgttcc 2277961 cgcagaatag acatgtggct tgtcattttg ctttgcagtt catgcccctc tatatccggc 2278021 acctcgtaga agacactggt ttctagccct gattgatatt gcctgttata aaccggtttt 2278081 tggataatat gctctgctgc cctttttcca aataccagcg cttccaataa agaattgctt 2278141 gcaagccggt ttgctccatg taaaccggag catgctgtct cgccaatcgc ataaagcccc 2278201 ggcactgtcg tttctcccca gcgattaact gaaacacctc ccattaagaa atgcattccc 2278261 ggagcaacag gaatttttcc gctgtggata tcaatccctg ctttttcaca aatagcggtg 2278321 atggtaggga aacgcgtttc aaaatcagaa atcgcactga agtctatata aacgcgattt 2278381 ccttttgcca tttcttcgtg aataacccgt gagacaatat ctcttggagc caggtcacct 2278441 aaaggatgcc gttcagccat aatcctgcgg ccgttttcgt ctactaaaca tccgccttcc 2278501 cctctgacag cttctgaaac aagcccgtag gaaacaccat ttttcacaag cagtgtcggg 2278561 tgaaactgag taaactccaa atccgttaat tccgccccgg cccggtaagc cagagaaaga 2278621 ccgtcacctg tgacagtgag atcattcgta tggtgaagaa acaggtttcc acagccgccg 2278681 gcagccagca caacttcgtc tgcgtgcctt accttgagcc gccctttgct gtcttttgtc 2278741 atgacgccga tacatcgtcc gtcctctata agcaaatctg ctgccgtttc attctcgatt 2278801 aacttgattt tgctgttgat ccgtttgagc aaataatcga taagcagcct gcctgttgcg 2278861 tctccgcctg catgaaatat gcggttgtat gagtgggccc cttctcttcc aagacaaaca 2278921 ccgcctcgtt cattgcggtc gaatggaaat ccacgctcca ataggctttg aaccatcatt 2278981 tttccatcat gtaatacgtc tgctacaata gctagattat tatggccgca ccctgcgtat 2279041 aacgtatcct ccagatgggc ttcaatcgag tcatcttttg cataggccgc agcaatcccg 2279101 ccttgtgcat agacagaatt gctgtttttg acgctttttt ttgtgataac agtcacttcg 2279161 tatgagggcg ggaaagctgc agctaaggaa agtgccgccg cccctgaacc gatgactgca 2279221 atcgtctttt tagacatatg ccatcctcct gttgtttaca cctgtcttga cacctatatt 2279281 tacacaagga taaaataaac tcaagagttt tttatggaga acggatggag gaagaccgga 2279341 tgatttattt agattatgca gcgacaacgc ctatttgtga ggaagccctt actgtatatc 2279401 agaagcttag tatggatatg tacggaaatg ccagcagcct gcatgatgca ggaggaaaag 2279461 caaagcacat actggagtac tgccgtgaaa aaatcgccaa catcattggc ggagaagcaa 2279521 gcggcatcta ttttacaagc ggcggcactg aatccaattt tctggccatt caatcattgt 2279581 taaacggcct gccaaaaacg aaaagacatt ttattacgac tgccatggag catcagtcca 2279641 ttcataattg cgctgctttt ttggaacagc agggatatga tgtaacagtc attgaaccga 2279701 atgaatacgg gcttattacc gaggaaatat tactaaccca tatccggccg gaaacaggcc 2279761 ttgtatctat tcagcatgca aattctgaaa ccgggatcat tcagcccatt caacacctgt 2279821 cttcatacct gcacaataag gggattcttc ttcattgcga cgctgttcaa acgtttggaa 2279881 agatcccgat caatacaaaa aatctgggag tagatgcact ctcaatgtcc agccataaaa 2279941 tccacggtcc taaaggagta ggggcggtct atatccggcc ggatgtccct tggaaacccg 2280001 tttatcctct gactactcac gaatacggat tcagagccgg caccgtaaat gttcccggga 2280061 tcggtgcctt cactgccgct gcagaattga tcgtaagcga aatggaaaaa cagatatccc 2280121 gcaatgaggc attaagaaca tactttctag accaaatccg tattcggtct ctccctgtaa 2280181 cccttgcagc agacacttcg aaagcagaat gtcttccgca tattataggg tgtttttttc 2280241 actcatttga aggacaatat gttatgttag aatgtaatcg gagtaatatt tgcatttcaa 2280301 ccggcagcgc ttgttctgca ggttaccacg gtccgtctga aacaatgaaa gcattaagaa 2280361 aaaccgaaca agaagctctg caatttatcc gcatctcttt tggcaggcat acaacagctg 2280421 aacagctgga acagttatta catacgttta cagtgctttg ggaacaaaag aaaggagaat 2280481 ttgatattga ccgaagaatt aaagctaatg ggcgccaaca ggcgtgacca gcttcttctg 2280541 tggctgaagg aatctaaatc accgctgaca ggaggagaac tcgcaaaaaa agcgaacgtc 2280601 tcaagacagg ttattgtaca ggatatatcg ctcttgaaag cgaaaaatgt accgattatc 2280661 gccacaagcc aaggatatgt atacatggat gcagccgctc agcagcacca gcaggcagaa 2280721 agaatcatag catgtctgca cggtcctgaa cggacagaag aggaactgca gctcatcgtc 2280781 gacgaaggcg ttacagtaaa agacgtaaaa atcgagcatc ccgtatacgg agatttaact 2280841 gcagccatcc aagtaggcac ccggaaagaa gttagccatt tcatcaaaaa aatcaattct 2280901 acgaatgctg cctacttatc acagctgacc gacggcgtgc acctgcatac actgacagca 2280961 cctgatgaac atcgcatcga tcaagcctgc caagccctcg aagaagccgg cattttaatt 2281021 aaagactaaa aaaagccctc tagtgggctt tttttataat tggtaagact ggtatgcacc 2281081 cagaagcctc actttgcagc cgagtgcttc aagctcctgc atggcccctg gaatcaatac 2281141 atcatcaaac gctttctcaa tatcaataat aaagaaataa tggcctaatc cggttttagt 2281201 cggacgtgac tcaatttttg acaggtttaa atttctccaa gaaaatgcag acagcactct 2281261 atgcagcgcc ccggactgat catcctgcgg cagcatgacc attaaggtcg ttttgggcct 2281321 agagctcaat tttgaattca cttcaaaaga tatgttttca tcgggagaca ggataacaaa 2281381 tcttgtatga ttgtccctat aatcctgtat atcccgtttc acgattttta attcgtatgt 2281441 agaagctgcc atatcattgg caatgacccc gatattcagc tcgggatggt cactgacaaa 2281501 ctttgctgcc gccccggtag aattggcgta ttcatatgga acggaaggaa aatgtcgatg 2281561 aagaaattta tggcattgcg caatcgcgtg tgaatgtgag taaattttgt cgagctcttt 2281621 ccatgcattc tctcttgagg gatggacgag caagtgctgg tgaatcggca acgtcatttc 2281681 acccacgatt ggcaaaggct gttcatgtat taaatagtct attgttagat taacagatcc 2281741 ttctaaagca ttttccaaag gaacaaaagc aaaatcaact tcgcctgcaa cggctgcatc 2281801 tatacactcc ggaatggtgc ggtaagcaac atgttcggcg ccgttttgaa aacaagaact 2281861 gactgctaga tgtgtaaatg tagctgctgg acctaaataa ccgactttca tgacgatttt 2281921 ctctccctta tgcacctgaa cctaatattt caaccttttc tacaaaatca aacttcctga 2281981 gcttattcat taatgtatga atgtcttctt ccattgccga cgtactgata gacagtgtca 2282041 catttgctct gccttgaagc ggaatggtct ggtgaatgga aagaacgttg cttccagaat 2282101 cagctaccgc ctgaagaagc tgagataacg cacctgacct atcctccaaa tgaaagaaaa 2282161 gtgtgataat ttgttctttt accatggtgt agaatggaaa aacagcatcc ctgtatttat 2282221 aaaacgcact tctacttaaa tcgacctttt gaacggcatc tgctactgaa tctgcttttt 2282281 ttcgatcaag cagctttttg acttctaatg tttttctcat tgcatcgggc aatacatctt 2282341 cacggacaag ataaaatgtc tcctctttca tttgcatccc ccctttaaaa tagagagcct 2282401 ggcaccaggc tctcttttca gccaacattg attaatcaat aaattcaaat tcaaattcca 2282461 gaagcctgat tatatctcca tccttggctc cgcgttctct gagtgcttca tcaacaccca 2282521 ttccgcgcat ctgtcttgca aaccgtttaa ccgattcatc acgtgagaaa tcagtcatct 2282581 tgaataaccg ctcaaggctg tctcctgaaa gcacaaatac accgtctgga tcgcgtgtaa 2282641 tgttaaatgg cacttcttca ttttccatcg tgtacatgac acggttttgt gtaagctctt 2282701 cctcgtcata cagcgggaat tccggtgtgt tctcaagctg attggcaacc tcaaacagaa 2282761 gctcacgcag accttctctt gtcaccgcac tgatcgggaa taccggataa tcatccgtca 2282821 gcttttcttt aaaggcttcg agattttccg cagcctccgg catgtccatt ttatttgcaa 2282881 cgataatttg cggacgctca gtgagacgca gattgtactc gctcagctcc tggttaatcg 2282941 taagataatc atcatatgga tcacggcctt ctaagcctga catgtcaatg acatgaacaa 2283001 taaccctcgt ccgttcaata tggcgcaaaa actggtggcc cagtccgacg ccttggtgtg 2283061 cgccttcaat cagccctggc aaatcagcca tgacaaagct gcgtccgtca tccgtttcaa 2283121 ccatgccgag attcgggaca agcgttgtaa agtgatagtc cgcaattttc ggttttgcag 2283181 atgagacaac agacagcaaa gtagattttc ccacactcgg gaacccgaca agtccgacat 2283241 ctgcaagcac ttttaattca agaacaatgt agcgttcttt tcccggctcg ccgttttctg 2283301 aaagctgagg cgcgggatta gccggtgtag caaagcggct atttcctctt ccgcctcttc 2283361 cgcctcttgc aatgacagcc cgctgtccgt gctctgttaa atcagcgatg acctgttttg 2283421 tatcatcgtc tgtcacaacg gtgcccggcg gaactttaat gaccatatca tcagcatttc 2283481 gcccgtgctg gtttttggac atgccatgct cgccgcgaat cgctttaaag tgttttttgt 2283541 atctaaaatc catcagggtg cggagacctt catctacttc aaaaacgacg tctcctccct 2283601 ttcctccgtc accgccggca gggccgcctt tcggcacata tttttcacgg cgaaacgcaa 2283661 ccataccgtt gccgccgtcg ccgcctttta catatacttt gacctgatct acaaacataa 2283721 tgtcctccgt tctaaaccgt taaaaactcc gctagtccaa cccaatttca atcagacatt 2283781 cgtgactcgt gatttcaaaa cgcatgatat caacgtcctc atatccattc tgccgaatat 2283841 catcaaaagc agatggatcg gcaaaggcgc cgtgaaaatc aaggtacaga atcagctgtc 2283901 tgtcaggatg atccgtttga agcgaaaccg ttaaatgatt ttcactctct ctgctgactg 2283961 cttgatcaaa cagatgaaac agctttctca tcagtttcgc cagcttttga tcataagccg 2284021 acaaatcctt aatttctccg agaacttcat attcaagcgt catataatgg gttttccaat 2284081 taaacgtaag aaaatcaaac gccaaatgcg gtgttttcag gtttgagagc tttgattcgt 2284141 gctttgcgtc tataaccatt tcttcaatca tttcaaagac acggtcatac ttctgtaagc 2284201 ttaagtttcc tttaatcagc tgcagcttat tcatccaatc atgccgggaa tggccaagca 2284261 gatgaatcag ttcgtttgtt aatgccgtgt cgcttatatt ttcttcttga ttttttgaaa 2284321 catccttcat tttcgcactc ccaatcattt aatttcttat ttaggagtct gtataagtgt 2284381 gtattatgaa ttataacaga gaaggctttg ttagaaaaac aattgttttt cccagaaata 2284441 tcatgttcct tttttctggc tttggttgat ttgcagccag gcagaacatt ttatgtatta 2284501 ctgcttgggg aacatatcca gtgggtttga gatgtttatt ctcattcttg gcggggtctg 2284561 ctcgcacata ctctgcattt cattctaggt gtttactccg catattgcaa aaaaaactcc 2284621 agtcatcatc gaccggagtt ttttgaatca ttattgagct acaggatata cgctcacttt 2284681 tttgcggtca cggccgaaac gttcgaattt aacagttccg tcgattttcg caaatagagt 2284741 gtcatctccg ccgcggccca cgttttcacc tgggtaaatt tttgttccgc gttgacggta 2284801 aaggatagaa ccgcctgtta cgaattgacc gtcagcacgt ttagcaccta aacgtttagc 2284861 ctcagagtca cgtccgttct ttgtagaacc tactcctttt ttagaagcga aaaactgaag 2284921 atctaatcta agcatgtagc tcacctccta tattatgttt gtggtcacac gcaagttgtc 2284981 tttgtaatcc cgttcgattg tctccagcga aacaatcatg ccttcaatca gcagctgagc 2285041 tttttggcgt gcctctggat caagagattc agggaattca aaataaaaat aacccccgtc 2285101 ctctcctata tcaagaagcg gctcgaagcc cgcgagcaca atgaccgcgt taacggcccc 2285161 aaacacaacg gctgtcactc cggcacaaac aagatcttgt ccatgttcag caaaattcgc 2285221 atggcccgtc atttcaaaag acaatatgcc tttatcatga gaccttctga ttgttgcctg 2285281 aatcatgctt acgcgttgat tttttcgatc gtcactttag tgtaaggctg acgatgacct 2285341 tgttttttat gaacgttttt ctttggtttg tatctgaaaa cagtgatttt tttcgcgcgg 2285401 ccttgttttt caactttagc cgttactgtt gcgccttcaa ctgtagggtt gccgactttc 2285461 acgttgtctc cgccaacaaa caaaacgtct tcaaaagtaa ctgtttcacc tgcttcagca 2285521 gcaagttttt cgatgtaaac agtttggcct tcttcaactt tgatttgttt accgcctgtt 2285581 ttaatgattg cgtacattct ctgcacctcc tattagacta agactcgcca gataccaggg 2285641 ggctgtaaaa gctcttaaca cctgtactga gcggttgtag caatggtgct acatccataa 2285701 cattaaaaaa tataccaaaa tacaaggcgt ttgtcaatca gttttagtag ggcagaagca 2285761 gttcctccat ggaagaattc gtccgcttat cggcaaagta agcgtgcagc acttcattct 2285821 cgtcaagctg gctgagcttt tggcctgatt tttctataat aatcggatgc ttacagccac 2285881 gtttgaactc ggccatcaca tgatagactt tatcctccgc ctttactgtc agcggcagaa 2285941 gtttctcaag ctccctgttt tttccgtaat acctttcgag gagaaatctc acatggatat 2286001 agtgcctttg ccgatattcc tcaaacaagg aaacagccag aaagacaaac aaaacccatg 2286061 cgctgatttg cagaggaatc acgaataaaa cccagcaccc gagcagcagg cagaagcaga 2286121 gcgacgtttt tagattaagc cggtgagcct tttgaaaagg cagctgtttg gaaaacaaca 2286181 aaaataacag ttttcctcca tccagcggcc agatcggcag taaattgaca aataagatag 2286241 aaagattata aaaggtgaag agttcaaagg tatgctgatg aatcactgag acttctgcaa 2286301 gcatccaggc ggcaaactga agccagatgt gctgaagagg tccggcaata atgaccgcaa 2286361 actcttcctt taacggccga ttcccgtgct cttccacttc gaccgttccg ccaaacggca 2286421 gcaaaaaaac acgcttgatt ctccaagaaa aaaacacagc cagagcagca tgccccagct 2286481 catgaatcaa tacaatcagg agcagacata ataatgcttt catatggcct gtgagcaagc 2286541 ccagcgccgc aataatccaa agaaaaggat gcacatggat ctttaagata aggtcgagcc 2286601 atttattcaa atgaaatcac ctgaatcgga tcaataaatt tatcgccgtc tttcatggca 2286661 aaataataga cccctttatt atgatcatca agcttaatcg aaccgagctt tttgccttta 2286721 tccacaaaat catataaagc aacatccaca tctttgagct cgccatagat actataggtg 2286781 ttgtcagcat gctgcacctt aaccgtcagt cccgtttggc tgtctttgct gacttcaacc 2286841 acatagcctt cttttacgct atcaatctta tcactgcttg tttcgacttt aattccttcc 2286901 ccattgtcct gaaaatcctg ctgtactttc ccggatgcag gcgcgatcag atctttgcct 2286961 acttcaatct gctgttcctt atttttgtgt tcaggagcca ggaaagcaag cggatttccg 2287021 aatttggttt cgaaccaatg gcttgctgaa gcaaattgaa attcagtttc aaaggttttg 2287081 gctacggcgg gtttaatctg actgacgggt ccaatgtttg ttttataggc tatagctgaa 2287141 acgagaacaa ggcaggccga cagaagacat ttcaggataa ttgaatctgt tttcaccaat 2287201 gggtgttttc cgttgaatgt tggcatgtta tcttcgtaga ccggaagtgt tccatgcttt 2287261 tcctgatccg ttaccatcac ccaggacggg ggtttctgct tttcagaaac tgtctgagta 2287321 gagaaacgtt ttgagccgga aagctgcttt cttcttttct ctaatcgttt tctgatttca 2287381 tctgctctgt gactcattgc catcatcctt tgcattcgtt gggtttgtac atcatatgtc 2287441 ttgtccatgg caaatattcg gtttagtcaa gaacaaagca ggcaaaaaca aaaaaaacct 2287501 gacacagcat atgctttgtc agattcttct ctttgattct atcacattaa gatcttactc 2287561 cgaaaaatga cttaatctta gccatcattc ctttgttttg ctcttcaagc acctgtaaag 2287621 gaacagattc acctaagatg cggcgggcaa tattgcgata tgcaatggaa gcgcggtttt 2287681 tagggtccat cgcaatcggt tcgccatgat tggaagcttt aatgacttca tcatcatcag 2287741 ccacgattcc gagcaaatcg atcgacagat gctgtacgat ttcgtcgata tccatcgtgt 2287801 caccgttttt catcaggtga tttctgattc tgttaacaac gagccgcggc ggttcaatat 2287861 tttcctcttg ctccagcagt cctataatac ggtcagcatc acgaacagct gagatttcag 2287921 gcgtagtgac cacaatcgct ttatcagctc cggaaacggc atttttgtac ccttgctcga 2287981 ttccggcagg acagtctatg atgacatagt caaattcctg tttgagctct tggaccatgt 2288041 ttttaatttg ttcaggagca acagctgtct tatcgctcgt ttgagcagcg ggcattaaat 2288101 agagcagatc atcgaaacgt ttgtctttta cgagcgcctg atgcattttg catctgccct 2288161 ctacaacgtc taccagatcg taaataattc tattttcaag acccattaca acatcaaggt 2288221 tgcgcagtcc tatatcagta tctactaagc atacgcgctt ccctaaaatg gctaaggcgg 2288281 taccgaggtt cgcagatgtt gttgtcttac ctactccgcc ttttcccgaa gttattacga 2288341 tagcctcacc caattcacat tcctccctca agccttgtta gatcaggtct taaatgagcc 2288401 aaatgttgaa ggcgttcaat gaccatattt ccgtctgtat ctaaataagc acattccatt 2288461 tcgttccctt tttgaatgtg gtctggggag cgatttaaca catgattgat tcttaattgt 2288521 gtcggaagca tttcagaggc ggcgatgacc gcttgattat ttccattgaa tccagcatgc 2288581 gcaattcctt tcagtgagcc cagaacaaaa atgttccctc cggccctgac tgttccgccg 2288641 ggattcacgt caccgatcag gagcaagtcg ccttttacct gcagcacttg gcctgaacgg 2288701 acaatttttg aaacagaaat aatttcggct tcctctctta tctgctgtgc ttctttttta 2288761 gtaatgactt cactgtcaat agaatgaaca aacaaatctt tctttgacgc aatcaattcg 2288821 gttagctgtt cctcttgctc cttatataaa aagcgatttc ccagcttaac atgaacgctg 2288881 attttctggc cttttccatc ggtatattgt tcaattgaca gcatattctg aagaccatcg 2288941 agaagctcat caaaagaaca cgcatcatcc agatgcaatg ttagtccatt ctttgttcct 2289001 tttattgtta catattgctg ctttttggtc ttcacaatat tcacctcaac aacatactca 2289061 tttcgtcaaa aaaagataaa atccttttta ctcatctctc aattctttct ttagactcat 2289121 aaaaaacaat ctaaatggca gaacaagaat aagagctgct gcaatattta ataaaattgt 2289181 cggtataaac cggtcaagca caaatccgtt aaacgtcata atgtctttat gaatcaaaga 2289241 ctgaatgccg aatacgtaaa attcgagcag acagacagcc agaactgcta tcaatatcac 2289301 tacaaatgcg tttgtatgca acactttaaa cgcttttgaa gccaaatagc atagccctgc 2289361 aaaaccaaac atgtaaacgc ctaatagact tgtatagttc atgtcatata gaaagccaaa 2289421 aataaatccg taaatcatcg cgtgtttttg gttgataaaa gccgacatga atatcaatac 2289481 aagcatcaaa aaacgcgggg cgagcacttg gtcatctgta acgaaaggaa aatgcaccaa 2289541 atctgtaaaa atgctttccg cagaaaaaac aagcatcata acgaaaggga gaaggaaacg 2289601 tttcacgatc cttcctcctc tgtatcgaca gtcggcacgt cacggttaac aacgatcaca 2289661 ttatttaaat ctgtaaggtc agccgcaggt tttacataag caaccttcgt taatccatag 2289721 gaatctgact cgatatcagt cacttcaccg attgtcagcc cttctgggaa aacaccgcct 2289781 gtccctgatg tttcaataag atcgcctttt ttcacgtctt gtttatcctt acgctcaata 2289841 attgtcatct taagacgttt tttctctttg tcatatcctt cgatcaagcc gtagcctttg 2289901 ctgccttttt ttccggaaat ttttgtcgcg actctgttat tgcggtcagt atcgcttaaa 2289961 agctgaacag cagacgtaaa attgttaagt ccggagcttt tgatcttgcc gattaatgcg 2290021 cctttttcgt ttgtaacggc catatctttc gctacgtttt gctgagtccc cttgttaatg 2290081 gtgacctgtt tcgcccaatt atcagggctt ctggcgatga ccgttgctaa aatcggcttg 2290141 taatctttaa tcgatttgac atggccaagc tcgtcacgca aggatttgtt ttcttcttca 2290201 agctcttgaa gcttggcttc atattgtgtc tgtccgtcaa gtttttctct tagacgctcg 2290261 ttttctttgt atgtgttttt taaatcattg atgttctcaa atattcctgc aaaaaattcg 2290321 gcaggcgtat gaaaaatatt ttgaaatact cccgtcgtat cgccgatcac tttctcaggc 2290381 caggtggtat tgcggccgcc cttcagcgaa aatccaatca tagccaccaa tatgataata 2290441 cacagaagta atagcattaa ccgcttattc ggcatcgtgt tacacctctt ctattgaact 2290501 cccgattatc tagttttccc tttgaaaaga tggatgtgct ccagtgcttt ccctgttccg 2290561 atcgctacac aatcaagcgg atcttcggcg ataaggaccg gcatttttgt ttcttcgctg 2290621 atgactttgt ccaaattgcg caaaagcgct ccgccgccgg ttaacactat acctctgtcc 2290681 atgatatctg ctgcaagctc aggcggtgtt ttttcgagtg tgctcttcac tgcttcgaca 2290741 attgtagata cagtgtcgcg tagagcgtta gaaatctctt ttcctgtaat ttcaattgtt 2290801 ttcggcaaac ctgtgagcaa atcgcggccg cggatttcca tgttgtcgga ttcttcagga 2290861 gcttctgcag atccgatttc cattttaatc gcttcagccg tacggtcacc gatcatcaga 2290921 ttgtacgttt ttctgatgta gttgataatc gcgtcatcca tctcatcacc ggctacacgg 2290981 attgactgag acgttacgat gcctccgagg gaaataatcg caacttctgt cgtaccgccc 2291041 ccgatatcaa caaccatgct tccagtcggt tcccaaactg gcagattggc tccgattgct 2291101 gcggcaaaag gctcttcaat cggatacgcg tcacgcgctc ccgcctgtct tgtcgcatcg 2291161 ataacagcgc gttcttcaac agctgtaatg cctgatggga cacataccat tacatatggt 2291221 tttctggcaa acatgccttt attttttatg gcctgattga tgtaatattt catcatcgtc 2291281 gccgttgttt cataatcagc gataacgccg tctttcatcg ggcgaagagc caccacgttg 2291341 cccggtgtcc gtccaatcat atttttcgca tcatttccga cagcgacaat cgatttcgta 2291401 tccgtctgca aagcgacaac tgacggctct ctcacaacaa ttccttttcc ttttacaaaa 2291461 acaagcgtat tcgcagttcc aagatctata ccaaggtctc tagcaccaat tccaaacata 2291521 tgtatgtatc ttcctttctt aaagcaaaaa taccctaaag ggaaaaactc ataaactcta 2291581 ttatagctta attcgacgaa aaaaaaagtg ttacaaatat cctttttcct ttaaactcac 2291641 aaatttttta tccccgatca ccaaatggtc aagcagctcg atgccaatca ggtttccgca 2291701 ttcaaacagc cgtcttgtca cttcaatatc ttccctgctc ggcgtcggat ctccagaagg 2291761 atgattatga acacagataa aggaagcggc agatcgttta aacgcttctt taaacacctc 2291821 tcgcgggtgg acaatagatg aattcaggct tccgataaat acggtgcgtt tatggatgac 2291881 ttgatttttt gtatttaagt ataaacagac aaaatgctcc tgggttaaaa agcgcatatc 2291941 ctccatgaca agattagcgc cgtcttccgg ggagcgaata acgaaatgtt cttcgttggc 2292001 taatttatga atccggcttc caagctcaac tgctgccagt atttgaatcg cttttaccat 2292061 accgattccc gggatgcttg acagctcttc aaccgatgct tccttgagca ggcgcagccc 2292121 gtcaaatgag cgcagcagcc ggtttgacag gtccaaaaca gattcgtgtt tagtccctgt 2292181 ccgcaataat atagccaaaa gttcatgatt cgctaagttc tcggctccga ctttcaggag 2292241 ccgttccctt ggcttttctt tcattgggaa atctttgagt tttaatggca gatcgtgtat 2292301 gaccaagcac tccttttctt tcccttcccg tttatagaac cgtcatgccc ttatatcaaa 2292361 atggcgaaga gctctcattg tttttgatat aggaaggccc atgactgaat aataatctcc 2292421 gtctattttc tttacaaaaa gcgcgcctct tccttggatg ccgtatgcac ctgctttatc 2292481 catcggctct tttgtttcaa tatatgtcca aatctcttct tcactgaggg accaaaacgc 2292541 aacttctgtc ttatcataaa aagtctcgct gtgattttca gcttgaatgc tgaccgcggt 2292601 tattactgag tgacttcggc ctgaaagcct ccgcagcata gaagcagctt cttcttgatc 2292661 ctgcggtttg ccaagacatt cgccgtcaag gcataccatt gtatcagcac cgataacgat 2292721 tgcatgcggg tggagatcag ctacagcctt agctttttgt tttgccaacc attggacgtt 2292781 ttcttctggt gaaaagtttc gatttaattt ttcttctact tcactgacaa taatggagta 2292841 gggcagctgg agaagatcga ggagttcttt cctgcgcgga gattgtgatg caagtattag 2292901 cggttttgtc atgttcgtca tcctttcagg gtttgcttaa gaaaaaaaga tactcgttta 2292961 tcctaccaaa tcacgaggct tgtcacaatt tcagaaaaat aactttttca tgacaaaata 2293021 aaaaaagcct gtcactaaag gacgaaggct cagggcacta tctcttattt tacgacggct 2293081 aacagctcct gctgagcctt ccacccggct tcagcacttg gatcctctaa ttcctttaaa 2293141 gcctgcaaaa tcgctttttt ctctcctgtt tctgacgctt ttgtttcacc aagcgacttt 2293201 tctattttct ctacactcgc ttttgtaatg tcttcgtcga gaatcgcctt tgctgcaagc 2293261 tccgctgttt ccttaaaaga atctgtcata tctgactcta ttgataagga aagctccttg 2293321 cctccccagg cttcaaaatc actgtcgatt aaaacctgtc ctaactgctg tgagacctcc 2293381 ttttcacttg ctaagcctgc aataacatac gtatacccgt catcctttga cagtgacacg 2293441 gcggaatatc ctttttcggt caattgttct gttaacgttt cggcgccctt ttcatttgaa 2293501 aattttccgg cttgcacagc gtatgttttg tatgtacctt cagtttgtgc cgcttgtttt 2293561 tctgcgcctg aggtttgttt atcagcagaa gtatcccctg cttttgccgt ttggctgcct 2293621 aaagaatcct ctaaagaggc cggtgctgac gcttctttat tccccgatat gtttaacgcg 2293681 aataacccta atccagtgcc aatgacagcc gcgaaggcaa tcgtcgcggc cactcttttt 2293741 accggtttgg cagccccggt ctttcctttt gcgtaaagct ttgttttttt cttttgaaaa 2293801 ggaggaacaa ctttagggtc ctctttaaac accttgtcct cctcggaatc ccaattgaat 2293861 tcatcttcat cagggtgttc ctgggatgcc gcaacctctt gttctgcctg tcttttttcc 2293921 tcccaatttg aaaatgtcat gcttttattc gcctctgtct caggcgtctc ttgttcgtaa 2293981 accgtctctt cttttccatt aatcgtcacc ttgagggctt tttctgcggc tttactgttt 2294041 tttttattct ttcttttttt caattccgct tcctcccttc atttgcttga ccgttcttgt 2294101 cggcttttca tgctacacac tttagcacag gcaaagaaaa aaagaacaag acttttgtcg 2294161 ccttgtccaa aaaacgttcg tcaaattttt cagcagtcag cccaatgcca ttttgatata 2294221 aaaagaaatg atagagtcac cgtataaata ggctaaaatg ctccctgcgg ctatagcggg 2294281 ggcgaaggga agcggctgcc ttttagcgag tctaccagtc agaacagctg ccgctccata 2294341 taatgcacct atcaaaactg aaaagaaaaa ggcagctgcc agcattttca caccaagcac 2294401 aaagccaatc accgcaaata atttaatatc tcctccccct actcccccat gggtgattgc 2294461 ggcaattaca gccagaaaca aaaatccggc tgccgcacct aacaggcctg cataccagga 2294521 atcaagcgga gaaatcaatc tcgcggccgc caaaaaggga agaaagaaaa tcaatattcg 2294581 atttggaatc agcataaaat gaatatctgt cactgcaaca ataatgagaa gagagataaa 2294641 caccacagcg ggaaacagtt ccagcgatat gccaaagcgt attcctgcgg cggcaaataa 2294701 acacgctgtc acaagctctg ctgcgggata cataaaagaa atcctatgcc cgcagctttt 2294761 acatttacct ttttgaaata ggaatgacag gatgggaatt aattctgcag gagttaatgt 2294821 tcgccggcaa aacgggcatg atgaacgggg cgcaataata gatagatgta aggggatacg 2294881 gcacccggcc gtatagtaaa aagaaccaag gataagcccg aagataaaaa gaatggatag 2294941 catagacaac acacctttac tcattgagtt ctggtatgga ttgtagcaaa atggacatcc 2295001 tgagctccaa ttgggaatat tcaattttac acatgaaaaa aacggcagaa tctttttttg 2295061 attctgccgg agccggatgc ttttatttca acctttttcg aatgtcagaa ataaagtaaa 2295121 gagatccggt aatcagcaca atttcatttg agcccttttt actttctatg aatttgatta 2295181 catcgtctgg atcttcactc cagcttttat tgctgatttc acttgcatca tagagatctt 2295241 ttgcaaggga agcacgcggg aaatcaaaag aagcaaaatg aatcgcatga gcaatggttt 2295301 ccagtctttt aatcatgttc tgatacggtt tgtcctttaa cgcgctaaac accacagaaa 2295361 tgcgtgaatt ggcgaaacgc tgcttcatcg tttccgccag cttttcaaca ccttcttcgt 2295421 tatgcgcacc gtctaaatat accggaggat gttcctgaac aagctctaac cgtcccggcc 2295481 aagcagcctt cacaagcccg ctccttaacg cttcgtcact gatatgggcg atattctcct 2295541 tattgagcca ctccgcagcc aaaatggaca aagcagcatt ttgtctttga tgggtgccaa 2295601 tcagagatgt ccgaatatct tcatagcatt tctcttccgt tttgaatgaa aactgttctc 2295661 ctgcaggcag agcctcttca ttgaaaataa cacatgcatc atgcaatgac tggaacggcg 2295721 cagcatgccg ttcggcttca tggcggatga cctgtaaagc ttccggctgg gtaactgctg 2295781 taacgattgg aataccttct ttaataatgc cggccttttc tcctgcaatt tcttcaatgg 2295841 tgtttcccaa aatgttcata tgatcgtgtc cgatgcttgt aatcacagtt aagagcggtt 2295901 caaccacatt agtagaatcg aatctaccgc ccagacctgt ttcaaaaata acaaaatcga 2295961 ccttatgaaa ctctgcaaaa tataaaaatg cacaagctgt cataatttca aattctgtcg 2296021 gctgtccgta ttccgtttga tcaagggctt caacgtgcgg tttcatttga ttgacgagtg 2296081 ctgtccattc ctcatctgaa atcggtatcc cgtttacgct gatccgttca ttaaacgtaa 2296141 taatataagg cgatgtaaat gttccaaccg tatatccggc ttcctgcagc atagaacgga 2296201 taaaagcgac agttgatcct ttaccgtttg ttcctgcgac gtggaacgct cggatttttt 2296261 tttcaggatg tcctaaccgc gccatcagct gtttcattcg accaagtccg ggcttcaccc 2296321 cgaatttcag cctcccgtga atccagctgc gcgcatcttg atatgcagta aacaatgata 2296381 atcccctctt ttataagaca aggcggtttc tctagaaacc gccccggctt ttcattaacc 2296441 cttcagctca gccattcgtt tttgaacagc gtcacgcttc gccacataat ctttttcttt 2296501 ttcacgttct tcatcaatta cgtgtgcagg cgcttttttc ataaatcctt catttccaag 2296561 tttcttttgg acacgctcaa cttcttttgt cagtttatca aattcttttt gcagacgggc 2296621 aatttcttca tcaatattga ttaagccttc aagcggaaga ataacctctg ctcctgagac 2296681 aacggccgtc atcgccttat caacagcctc aatatcggtg ccgattttaa gcacgctcgg 2296741 attcgtaaag cgttcaacat atgaacggtt cgcttcgagg cgggacgcta tttcgtctgt 2296801 gcttgtttta atgtacagtt caacctgctt gctcattggc gtattgactt cactgcggat 2296861 attgcgcaca gaacggatca gctcaacaag aagcttcatg tcagctgccg cttcagtatc 2296921 ggtatgctcc ggcactactg caggccattg acttactgta atcgattccc cttggtgagg 2296981 aaggtgctgc caaatttcct ccgttaagaa tggcataaac ggatggagca gacgcatcgt 2297041 ttgatcaagt acgtaagcaa ggatggaacg ggtagttttc ttagccgctt cgtcttctcc 2297101 ataaagcgga agcttcgcca tttcaatata ccaatcacag aaatcatccc aaataaagtt 2297161 atataaatgg cgtcctactt caccaaattc atatcggtca gcaagctggg tcacgtgctc 2297221 gatcgtttca tttaatcgcg ttaaaatcca cttgtcagcg actgactttt cacctgacag 2297281 atcaagctca tcgtacgtca tgccatccat attcattaat gcaaaacggg aggcgttcca 2297341 aattttattg gcaaaattcc aggtcgattc cactttttca tagctgaagc gcagatcctg 2297401 gccaggagag cttccagtcg caaggaaata acgcagagaa tcggctccgt acttgtcaat 2297461 cacatccatc gggtcgacac cgttgccaag agatttactc attttccggc cttgctcgtc 2297521 acggattaag ccgtggatta aaacatcttt gaacgggcgc tcgcctgtaa attcaatgcc 2297581 ttggaaaatc atgcgtgata cccagaagaa aatgatatcg taccctgtca cgagaacatc 2297641 tgtcggatag tagcgtttaa agtcttcagc cgttacatca ggccagccca ttgtggagaa 2297701 aggccatagc gcagaactga accatgtatc cagtacgtct gtatcctgtt cccaattttc 2297761 gctgtcttcc ggcgcttcaa gtccgacata tagctcgcct gtttctttat gataccaggc 2297821 aggaatacga tggccccacc acaattgacg ggagatacac cagtcgcgga tattttccat 2297881 ccagtgtaaa tacgtttttt cgaaacggtc aggcacaaag ttgacctttt cttctttttt 2297941 ttgcagctca atcgctgcat cagcaagcgg ctgcatgcgc acaaaccatt gtgtagaaag 2298001 ataaggctcc acaacagccc cgcttcgttc actatggccg acagagtgca tatgatcctc 2298061 gatcttgaag agaactcccg cctcctgtaa atctttcacg agctttttgc ggcattcaaa 2298121 acgatccata ccttgatatt ggagcgcatt ttcattcatc gtgccatctt cattcatgac 2298181 aaggatgcgt tctaaattgt ggcggttgcc aagctcgaag tcgttcggat catgagcagg 2298241 cgtaattttc acggcacctg aaccaaattc catatcaaca tagtcatcac cgacaatcgg 2298301 aatttcacga tttacaatcg gcaggatcac cgtttttccg ataaggtgtt tatagcgctc 2298361 gtcttcaggg tgaacggcaa cagctgtatc accgagcatt gtttcaggac gtgtcgtcgc 2298421 aatttcaatt gagcctgaac cgtcagcaag cggatagctc atatgataga atgcgccttg 2298481 aacatccttg taaatcacct caatgtcgga tagggctgtt tttgtcgctg ggtcccagtt 2298541 aataatatat tcgcctctgt agatcaggcc tttttcataa agcttaacga atacttccct 2298601 taccgctttg ctcaagcctt catccagcgt aaaacgttca cgggaataat ctaggccaag 2298661 acctaatttc gcccactggc tgcgaataaa gtcagcatat tcttccttcc acttccacgt 2298721 ttcttcgagg aatttttcac ggcctaaatc gtagcgggat ttgccttctt cacgaagttt 2298781 cgcctccact ttagcctgtg tcgcgatgcc ggcgtggtcc atgccaggaa gccacagcac 2298841 atcatagccc tgcatgcgtt tcattcttgt tacaatgtct tgcagcgttg tgtcccatgc 2298901 gtggccaagg tgaagtctcc ctgttacgtt tggcggcggg atgacaacag agtatggctc 2298961 ttttgtctgg tcactgcccg cttcaaaaaa tttgcctttt agccaaaaat catatcggtc 2299021 tttttcaacc gctgccggat catatttcgt cggcattgtt tgttcattcg tttccatcat 2299081 aaccctccag catgtttaaa aatggctgag aacgaaaaaa gagctcttca tccctgtaaa 2299141 aggacgaaaa gctctttcgc ggtaccacct tttttcatga actcaatcag ttcatgcact 2299201 tataacggat aacgggtgtt tcccgaattt ctctactctt ctttcaagaa attatgctcc 2299261 cgggcgacct tccaatcaga caacataaga agcctttcag caaacggctt ctctctctgc 2299321 atgcgccttt tttgtactct tcccgttcta agcaggtgta tttatcagct cattgtatac 2299381 attatttatg ttctttatta tagtaaaagt gtttttgatt cgtcaatcat cttttccaaa 2299441 aacaccgctt tctatacaga tgggcaggca cctattgccc aagtttacat atgatgcttg 2299501 taaatgcgta gaggaggatg caccgtgaag aaacgtttca gctcttattc gctgccgcca 2299561 tgggtaaggc aaattcggct tgtatccgca caagtgatta ttcccattac gatttttcaa 2299621 ggaatcagaa ccattttctt tccgacaacc tttgatgttt tgctgctcgc aatcctaatc 2299681 tttttagctt gcgcccttca tttagaatgg atataaacaa acaagtccgc gccattaaga 2299741 cgtggactcg ttttcagcct gaaatttttt ctcttgttca atctgatgaa ttttcatcac 2299801 aaacggctct atgtttttca tttgccaata agcctttaat aattgtgtac attcctcttt 2299861 ttcatgctgt cttttcccag tttgataacc gttcagcacc ttgtacatgg ctgccggata 2299921 tgccatatag ctgagaaaaa ggctgacttc cgcttcacgc aaagggaatg atttcgtata 2299981 tccataaaac cattcgacgc attccggaca agctttcgga aagcctctga acatttttgt 2300041 ataaaagccg agcaggtcgt tttgcggcgg accgacagat gctctttcga agtttgtaaa 2300101 atatccggtc ccggcatcat tatacagaaa atggtgtata gacaggctgc cgtggttcat 2300161 tacaaccctt gaaacgtcct tttcctttgc ggactcatac cagtcctcca gccgttccag 2300221 cgcaaagttc accgcggaaa tggtttcaga aaaataggtt atggcctgga gttcaaaggg 2300281 agaaaggtac cattccttct ccgctctatc cacaaactgc tcatagaaaa ttttatcttg 2300341 ttcccacttt tttttcgttt gcccgtaata acgttcaatc tcatcacgtc taacctttag 2300401 ttcctgcgcg gttctctcgt gaagacgggc tgtttctcta aataaataag catgtttttg 2300461 atcccgttct tcctcttggt caaattggag ccaaggcatt aaatagtaga tatctccgta 2300521 ttgtatgcct gctgagaaaa actcaccgct atttgttctg taaacgggaa cgaatgaacg 2300581 aaagcctttt tcctcaatcg ccaccatatg atctgtaaaa tgcttgccgc gaccttcttt 2300641 caattttttc agggcaaata tgccgtagtc tgtatacact ttccaaacaa gaggactgac 2300701 aggctcaata aattgagcag tcagtccgta ttcctgaaga accgattggg tatcttccat 2300761 ttcattcacc acattttccg atcacttacg gtttacgcat ggctattttt atattgagga 2300821 atatagagaa tctgtcctgc ttttaattca tcatccaagg ctaaagaatt catcctgatc 2300881 agctgctggg atgtaatttc ataccgttcg cataaacgct cgatcgtatc ttcctgctgc 2300941 acaatacaaa ttttcattct cgaaaactca tccgcttctt ttgtaaagag ttttgttaaa 2301001 taaagagaat tatcactttc ctttgtttga ggttccttcg tttcagcagc aggagcaacc 2301061 ctaggaacag catccgtttc cttcctttca gtctcagaag attcaggcag ctggaaggat 2301121 tgaaaaggtg tttcttcctt aggctcttca gctgatggtg tttttctcac ttcaatttcg 2301181 aagctctctt cctcttgttc ttcctcctcc agcagcttag gcgctgaata aaaagaatcc 2301241 tcctcttctt gttcaggcag gaaggtacgg tatgccggtt caggcaattc ttcttgagat 2301301 gcctcctccg agcttgtttt ttgattgaaa tggaaatgta aatcggcatt gtcattctcc 2301361 atatatacag ctgaagctgt ttctctgcta tcttctatgg agagagcggc ctctgataca 2301421 ctctccaaag cttcatccgg ttccgcctct tcttggcaaa gcgcaggatc agcctgatcc 2301481 gattgagctg cttcttcatt ttgagcctct tggcgcagcg catattcatg attaggagac 2301541 actgttgttt cctctttttc ctttgcaatc acagtctctg aatgaagctc agcttccaaa 2301601 gcaggcgatt cttctgctcc aacgtgttca cgaagctcag tctccgctgg agagtctgct 2301661 tcttcacgaa catccgctat tgcagctgcc ggctctgccg tttctttttt tgctttaacg 2301721 atctcttgaa tctctatttc tgaaggatca ggttctggct cagattcttc tgtttccgat 2301781 tcagcacgaa cctccgtttc cggcacagca agctcttctg actcttcttc ctctttcaca 2301841 tcttctctgg cctctggttc tgaagcaacc gattcaggcg gctcagattc tgctttttct 2301901 gtctccagtt cttcacggag ccccgctttc gagataaaaa gttctggcgg ttcggctggc 2301961 ggttcatgct gaagaactgc ttcctctgcc gatgatgcac ccggttcttc tactacacta 2302021 tgtgccggcg gctctgaaag ctcttcctcc ctgaatgccg caggagcttc atataaaggt 2302081 atctccggct ctttgtcttg cgtatcgtcc aaaagccctt cgatcgctaa atcagcttga 2302141 attgttaaaa tgcgcgaatc cgtcaattga tagtcaaatg cgtcaataaa gacgaagaca 2302201 tcctgtaaat ggctcacttt atttttcgga atggtaatat ccacaggaaa acagtgagtc 2302261 agttccgcac ttccatcctc tctctttctg acttgttcaa caaaccgctt atctgtataa 2302321 atctcttcgg tatgtttgtt ttgatctatg ttgtactcac ctgtaagttc aagcgatcct 2302381 atgattgata cataatcatt tacttcctga accctaatat caggatctaa tgaaatagaa 2302441 agcagttcag aaacttcctg tcctttttgg aaacagatcg attcttctac agaaaattgc 2302501 aatcgatgat tttgcggcaa gttcatatcc tcctttcatc taatccttaa aattagatgt 2302561 cactaaaggt gtatgtatga actggagaaa atatgagtgg gagagcacga aaaaaccggc 2302621 acaaggagtc cttgataccg gttttcactc ttatctgcgg ctgatctcag caaatacttt 2302681 ctcagctgcc tggattgtgt tttcaatatc ttcatcagta tgggccgttg agaggaaaag 2302741 accttcgaat tgtgatggcg gaaggaatac cccttcattt gccatccctt tataatagct 2302801 tgcgaacagc ttcaaatcag atgatttcgc tgtttcataa ttgatgactg gttcgtttgt 2302861 aaagaagaaa ccgatcatcg aacctgcacg gttaaaggta tgcggaatgc catgagcccc 2302921 ggcggttttt gaaattcctt cttccagtct gtcgcctttt ttgatgaaat tcttgtagga 2302981 ttcaggtgtc agctgtttca atgtctctaa gccagccgtc atcgcaagcg ggttgcctga 2303041 caatgtacca gcttgataga tcggaccgct tggagcgatc tgctccatga tttctgcctt 2303101 tccgccataa gcgccgacag gaagtccgcc cccgattact tttcctaaac aagtcagatc 2303161 aggcgttacg ccgaagtagc cttgagcgca gttataatcg acccggaagc cagtcatcac 2303221 ttcatcaaaa atcagcaggg agccgtactg ctcagtgata tcacgcagac cctgaaggaa 2303281 accttcttgc ggcggaacaa cacccatatt tccggcaact ggctctacaa tgactcccgc 2303341 aatgtcttca ccgaattgct ggaaagcaag ctttacactt tctaaatcat tgtacggaac 2303401 ggtgatggtg tttttcgcaa tgccttcagg cacccccggg ctgtcaggca gaccgagagt 2303461 ggcaacacct gaaccagctt taatcaagag agaatcgccg tgtccgtggt agcagccctc 2303521 aaattttaaa atcttgttgc ggcccgtata gccccttgcc aaacggaggg cactcattgt 2303581 agcctctgtt ccggagctta ccattcgtac aatttctaca gatggcacac gatcaatgac 2303641 gagcttagcc agttcatttt ctacttcagt cggagcacca aagcttgtcc cgtattcagc 2303701 cacttttttg aggctttcta cgacgcggtc atttgtatgc cctaaaatta aaggccccca 2303761 tgacaagacg tagtcaatat attcattccc gtcaatatca aagattttcg agccttttcc 2303821 gcgctccata aaaatcgggt ccatgtctac cgatttaaat gcgcgaacgg gactgttcac 2303881 accgcccggc atgagttttt gcgcttcttt aaaagccgtt tttgattttt catagcttct 2303941 catctgcctc aactcctgtc aactgaataa aattactccg caagccattt cgctgcgtct 2304001 ttcgcatgat acgtaataat caggtcggca cccgcgcgct tcatgcttgt caaaatttcc 2304061 aacacaattt ctttttcttt gatccagccg ttctgcgctg cagccttcac cattgaatac 2304121 tctccgctta cattataagc gacgagcggc aaagtaaact cattttttac gtcacgcatg 2304181 atatccatat aagaaagcga aggtttgaca atcaaaaagt ccgcgccttc ctcaacatct 2304241 gattgtgctt cgcggagtgc ctccatacgg ttggcagggt ccatctgata tgttttgcgg 2304301 tctccgaatt gcggtgtgct gtttgctgca tcacggaacg gaccgtaaaa ctcacttgaa 2304361 tatttaacag cgtaagacat gatgggaata ttgacgaatc cttctttatc aagtgcttct 2304421 ctgatcactg taacaaatcc gtccatcatg tttgatggcg caatgatatc cgcacctgct 2304481 ttcgcttggc tgacagctgt ctgcgccaaa agctccagcg attcatcatt gagaatgact 2304541 ccgtctttga caagtccgca atggccgtgg tctgtatatt cgcacaggca cgtgtcagcg 2304601 acaacaacca tttcagggaa gtgttcttta atttctgtga tggctttttg gacaattccg 2304661 tgatcatggt acgcttgtgt tccgcaatca tctttttctt ccgggatgcc gaacacgata 2304721 acagattgaa tgcccagttt gaccagctcc gctacttcat ccttcaataa atctaatgat 2304781 acatggtgaa catcaggcat tgacggaaca gcttttttgc cttccagccc ttcaacgaca 2304841 aaaatcggat atataaaatc tgatggatgc aaacgtgttt cctttaccat ttctctcatt 2304901 gcttttgatg tccgcaggcg gcggtgtcta ttaaatgatt gactcatatt ctctcttcct 2304961 ctcttgacat gctgcacatt aactcaagca tgccatctat tgtaaatgta tcaggcgtat 2305021 gcgatgtgat gccgtacgtc agaagggcat catttgttaa aggcccaatg ctgatacagg 2305081 ccgtcccatt cgccttccac ttttttaatt cttctcccaa gacatgcata aacgtatgta 2305141 cggttgatga actcgtaaat gttacatagt caaaggaata ttgacccgca gcgtctttca 2305201 atgcctcaat gccttcttca tccggaatcg tttcgtagag aacccattcc tttacttcaa 2305261 aaccgagcgg gacaagctct tgttttatca catcacgtga caaattccct ttcatcacgg 2305321 taatggtctc ccccggttca gcatgctgct taagagcgtc agccaattgt tcagcaatat 2305381 actcctgtgg catcacatca accgatacgt tatgcatttt taaacggcgc gcggtttttt 2305441 caccgacggc tgcaattttt ttatgcgcag ggagaataag ctgattttcc ttcagataag 2305501 aaaaaaagaa gtctgccccg ttcacacttg taaaaacaag ccagcctggc gcggcaagat 2305561 cctctcttac ctgttccgca acatcattcg gcaaagcgcg gcgaaacgta atcaaagagg 2305621 ttaaaaccgc tttaccgcca agcgcctcca ctttttgctg aaatgatgct gcctgtgcct 2305681 tattccgggt gacaagcact gtttttcctt tcaacggaaa atcattttcc atcctcgtca 2305741 agctcccgtt ttacacgatc aattaaatct tttgctcctt tgtcagccat aagagcggca 2305801 cagcgctttc ctacttcctc cggatcgttt ccggtgacgg tttctttaaa aatgattttg 2305861 ccgtcaggtg aagcgacaag acctgtcatt tcaatttcat cctgtccatt taacacggag 2305921 tagcccgcga tcggaacctg gcagccgccc tccatcgcgt ttaaaaaagc acgttccgct 2305981 aagacagtcc gttttgtata ttcatctgta aactgagaaa acaacgccaa cagctcttca 2306041 tccgattctc ggcactcaat cgccagggct ccctgcccca cagcaggcaa acagcgctca 2306101 ggctcaagga attcggttac gacatcttgc ttccaaccca ttctggaaag gccggcagcc 2306161 gctaaaataa ttgcgtcata atcctctgtt tccagctttt gaagtcttgt atctatatta 2306221 cctctaatcc atttaattgt aaggtcaggg cgctcaatca aaagctgcgc gcttcttctt 2306281 aaactgcttg tgccaatgac agcacctttc ttcatttctg aaagctttac gcgattcttt 2306341 gaaataaggg catcacgcgg gtcctcccgt tcaggaatac agccgatcac aaggccttca 2306401 ggcaaaacag caggcatgtc cttcatgctg tgcactgcca tatcaatctc ttcgtttaaa 2306461 agcgcctgtt caatttcttt gacaaaaagc ccttttccac ccacttttga gagtgtaaca 2306521 tcgacaatcc ggtcgccctt tgtcacgatc tctttaattt caaaagcaaa cgaaggattg 2306581 atttccttca gtttttgaat aacccatttt gtttgagtca tagcgagttt gctccgtctg 2306641 gaacctactt taatcgttct catcatttct ttcctcccga atctgcttgg gacatcgttt 2306701 aactgaacca atggaattgc gacaggcttc caagcaggaa ataattgatc atcagcacca 2306761 gaaaacaagc cgtattccac agtgcagcga cctttccttg cagctcctta atcagcctga 2306821 tataaagata atagctgtac agcagcagga cgacaaacga accaagcact ttggcgtcaa 2306881 accaatacag cgtttctagt gagacatacg cccaaatgac gccgagaatc aaactcagca 2306941 gcagcatcgg aaccccaatg acatttaaaa catacgccat ataatcaagc ttagataaat 2307001 cttctattct caacagccat tttccccact ttttcttttt cagcagatga tattgaaaca 2307061 tatatagcac agaaaaaacg aaagaaaggg aaaaagcgcc gtatgaaaga atcgccattg 2307121 taatatgaat caccaaaagc tcggatacaa gctgcccgga aaaagcagct gactgctgct 2307181 ctgtcggtga aaatgtgtga atggcgatca tagaaaatcc tataacattt gtaaaaaaca 2307241 cgataaagtc aacacgtaaa agctttgtca gtacaagtga cagcgtgaca agcacccagg 2307301 cataaaaata aagtgcctct gtcacattta ataccggaaa ccgccccgtc acccacataa 2307361 aataggccaa atacacggtt tgcagagtcc agacaataga aagcaaccag aaggccattt 2307421 ttccagcctt ccggttgtgt tgaagaaaat ctataaaata aaagagtaca cttaacgcgt 2307481 aaatgacgat tgtcccctca ttaagtcttg ccattgcagt atcaatcatt cagctttcac 2307541 tcacttacaa gtgggctaaa gcccgctttt gattcagcct tcttaaaaga gtggaccttc 2307601 tggctgcttt caacggtttt catcatttga cggcccgcag cttcttcaat atcaaaaatc 2307661 tgcataaaca acgcgagctt ttcttcagaa tcagcatctg ccgcaagctc tttcaccttt 2307721 aaaatcggat cacgaagcat ttggttaata atacttttgg tgtgtttgtt caacagtttt 2307781 ttctctcttg tgcttaagtg aggcagctta cgctcaatgc tgtccatcgt ttctgactgg 2307841 atggcaagcg ccttttcgcg caatgcagaa ataacaggca caacaccaag tgtattcatc 2307901 cattgtttaa attccacaat ggtttcttca attaacagtt caactttttc agctgtttct 2307961 ctccgctctt tcatgttcgc ttctacaatg ccttccagat cgtcgatatc ataaagaaaa 2308021 acaccttcaa gatcattcag cgccggatca agatctctag gcacggcaat gtcgaccata 2308081 aacagcggac gtcccttgcg aagcttattc gcgttttcca tcatctcttt ggacacgaca 2308141 aattcacttg caccggttga actgattaaa atatcagcct ccgcaagcgc gctttcaagc 2308201 tgattcaagc ttctcgcttc acctgaaaaa cggtctgcaa gctccttcgc tttcaagtat 2308261 gttcggttaa tgacagtgac cttgccgatt ccctgtccgt gcaggttttc cgcagcaagc 2308321 tcgcccattt ttcccgcacc gagaatcaat atgtgcttgc ttgaaagatt tccgaagatt 2308381 tttttggcaa gttcaactgc agcatagctt actgacaccg catttgagcc aatgtctgtt 2308441 tcggcgtgag tccgtttgcc cactgtaact gcctgcttaa acagctcatt aaaaatagtc 2308501 ccgatcgttt tttcttgctg agctgtttta aagctgtcgc gtacctgtcc gagaatctgc 2308561 gtttcgccaa tcaccataga atcaagtccg caggctacac ggaataaatg ctcaacagcg 2308621 gcatcgctct cataaaacgt taagaacggt gacagctctt ctttgcttaa ttgaaaccaa 2308681 tcagctaaaa acttttttat ataataacgg ccggtatgaa gctggtcgac taccgcataa 2308741 atttcagtgc ggttgcaggt tgagacaatg atgttttcaa gaatgctttt ctcttctttc 2308801 agctgcacca ttgcttctgc cagctcattc ggctgaaaac ttactttttc acgtatctca 2308861 ataggggcgg atttataatc tactcccaca acaagtatat gcatcgctct aattacaccc 2308921 ccaacaccca atcttaattt ataatcattc taacatagaa ctcattattt ataataatta 2308981 taacatagtt tctttcacaa aatgtgaaca gattttaaaa ttcttatgct atattagaaa 2309041 aagcttcagg gaaaagaagc attcctattg acaataccaa aaacagcaga aatttactac 2309101 acatcagctc taaaaaacaa gaaggtgata tgcatgaaac aaaaatcaat tttattccct 2309161 tgtctgctgc ttgccgcttc tgtatatgca tggctagaaa gcggccaagc cgaactgttt 2309221 tcagggcagg atcaatggcc tgttctcctc atgctgttag gcgcagcctt tgtatatcaa 2309281 ggaaaaaaag aagccgtcac accccatttt tttatcggtt tgcttctctt cgggatcggt 2309341 ttacactttt ttgccaagcc gaaatgggta tggtggccgg atgattttga aatgctcctc 2309401 tttatgatcg gcttctcact tctcgtttca accgttcaaa aaaaagaata tgtatatgaa 2309461 gctgtgtcga tgatttgttt ttccctgttt ttgtactttt tcaaacaaat tatggcatgg 2309521 cttgagtctg cgcatattcc aacagcgctt ctgaaggagt attggccgtt tgtctttatt 2309581 ggaatcagtt tattgttatt attgataaaa cgaaaaaaat ctatacgata aataaaaccg 2309641 gtagaggatc ctctaccggt ttatcatttt tttgatcgct ccccaagctt cgtcttttcc 2309701 ctttttcgtt tctgaagaaa agaggatcag ctcgtcttcc ggatcaatat ttaatgtttg 2309761 tcggacaacc ttcgcgtgtt tgtcccattt acctttcggg atcttatccg cctttgtagc 2309821 gataacaata acaggaatgc cgtaatactt taaaaattca tacatctgta catcatcatt 2309881 agatggcgca tgccgcaaat caacgatctg caccacagct tttaattcct cgcgtgtcgt 2309941 gatataggtt tcaatcattc tgccccatgc ttcacgctca gactttgaca ctttggcaaa 2310001 accgtagccc ggcacatcca caaaatgcag ctcatcattg ataatgtaga aattaagcgt 2310061 ttgtgttttt cccggctttg atgacgttct cgcaagattt ttgcgattga ttaatgaatt 2310121 gataaaagac gattttccta cgttcgatct tccggccaat gcgatttccg gaagcccccc 2310181 ttcagggtac tgttccggtt ttactgcact gatcacgatt tctgactttg tgactttcat 2310241 ttcttctctc ctactaaggc atgttccaaa acctcgtcta agtgggacgc caatataaat 2310301 gtcagcccct ccctgacgct ttccggaata tcctctatat ctttttcatt atctttaggc 2310361 gcaataatgg tcgttaatcc cgctctatgt gcgccaagcg ctttttcctt taagccgccg 2310421 atcggcagca cgcgcccgcg aagcgtgatt tccccagtca tgccgacttc acgcgaaacc 2310481 gcccgtcccg ttaaagcaga aacaagcgct gttgccatcg taataccggc tgacggacca 2310541 tcttttggca ccgcaccctc tggtacatgt atatgaatat catacttctc atgaaagtca 2310601 ggttcaatgc caagttcttc tgttttggat cgcacatagc tgaatgcagc ctgagcagac 2310661 tctctcataa catctccgag ctttcctgtc aggattaatt tcccttttcc cggtgaaagc 2310721 gatacttcaa tcgaaagcgt atctccgcca acggttgtat acgcaagccc tgtcactaca 2310781 ccaacttgat cctctgtttc agcttgtcca tatctgaaaa tgcgttttcc gataaaatct 2310841 tgaaggttct tctcagtaac cgtaattcgt tttcgctctt cagcaacaat ggcttttgca 2310901 gctttacggc aaattgcggc aagctggcgt tcaaggcttc ttacacccgc ttctctcgta 2310961 tagtaacgaa taatatcaag aatcgcctga tcacgcagct gaagattgct tttcttcagc 2311021 ccgtgttctt tgatttgctt tggaagcaag tgatccttta caatttcaag tttttctatt 2311081 tctgtgtagc ctgcgatatt aataatttcc attctgtctc tgagcgggcc cgggattgtg 2311141 gccaaattgt tcgccgttgc gataaacagc actttggata aatcaaaggt ttcttcaata 2311201 tagtgatcac tgaagctgct gttttgctct ggatcaagca cttcaagcat agcggatgat 2311261 gggtctcctc taaaatcaga tgacattttg tcaatttcgt ctaataagaa gaccggattc 2311321 agcttgcccg cttttttcat cccttgaata atacgtccag gcattgctcc gacataggtc 2311381 cgtctgtgtc cgcgtatctc tgattcatcc cgaactcctc cgagtgagat tctgacgaat 2311441 ttgcgtccca agctttttgc aattgatttg gctaaagacg tttttccgac acctggaggt 2311501 cctgccaaac agagaatcgg gcctttcagg gattttgtca gcttctggac agccaaatat 2311561 tctaaaatac gttcttttac tttttcaagc ccgtggtgct cttcgtccaa gagacgtcct 2311621 gcttctttca aatcaagctt atcatctgtt tcatccgtcc acggaagagc aaccagccag 2311681 tcgatatagt tgcggatcac agagctttcc gcagaacttg acggaatttt ttcatatctg 2311741 ttcaattctt taagcgctgt ttctttcaca tgatcaggca tgcctgcttc ttcgattttt 2311801 tccgtcagcg tctgaacttc gccagttttg ccttctttat cgccaagctc tttttggatc 2311861 gccttcattt gttcacgcaa gtagtattcc ttctgcgtac gctccatcga acgtttgacg 2311921 cgctggccga tttttttctc aatctccagc acttcttttt cattattaat aaaatcaatg 2311981 accttgttca gcctgtcttt gacatcagcc gtttctaaaa tatcctgctt atcctttagt 2312041 ttaaggggca gatgagaagc aacgatgtct gccattctcc ccggctcttc gatatcagta 2312101 accgcagcgt acgtttcggc cgagattttt ttagaaattt ttatgtactg atcaaagtgg 2312161 tctagcaaag tccgcatcaa tgcttcgtct tctgtatctt ttgaatcatc ttcatgaata 2312221 agttgaatgt caaccgacgt gtaatcctcg tgttcattgt atttgacgat atgggcgcgc 2312281 ttgaggccct ccaccaacac acgaatcgta ccgttcggaa gcttcagcat ttgcttaatt 2312341 tttgtatagg tgccgacagt gaaaatctcg tcttcaccag gttcgtctat cgaaatatcc 2312401 tgctgagtgg ctaaaaatat catatgatca tgcatcattg cctgttcaag agcctgaacc 2312461 gacttgtcac gtcctacatc taaatgcaaa accatcgtcg ggtacactaa taaacctctt 2312521 aaagggagga gcgggatgct gcgttttaat tcttctgcca tgtgactgac acctccgtga 2312581 ctttagtatg aaccattata atacaacttt ttcatccttg tacaataaac ggcatggttc 2312641 cattttctat aaaacagtct cctcgtagta taccctttct ttctgatatg aaaaaggaaa 2312701 agatgtcctt catgaaaaaa accctattat caaaataggg tttaaacgga ttctttattg 2312761 atttcgatat gaaacggttt ttgttccgtt ggcggattca ccaaaatttc atcaagcact 2312821 tcttggaacg tcttcactgc aataatctcg atcccgtcaa tctgctttaa gatggcctgc 2312881 tgattttcat atgggataat cacctttttc gcaccggact gcttggccgc ttttattttc 2312941 ggaatgacgc ctccgatggg tttcacaaga ccgttcaggc tgatttcgcc cgtcatcgca 2313001 acggtattgt caataggaat tttgtgtatc gccgagaaaa tccccgccgc catcgcaatg 2313061 cctgctgacg gcccatcaat cggaatccct cctgggaaat tgatgtgaat atcataatca 2313121 gaaggcttca ttcccattgt ccggagcacg gttaatacat tttcaaccga acccttcgcc 2313181 atgctttttc gcctgatcga ttttgattgg ctgccgatgc tttcttcttc agctattcct 2313241 gtgatgttaa ttgatccttt atcttgagcc gcggttacac ttacttcgat ttccagaagc 2313301 gatccgctgt taggcccata gactgcaagc ccatttacaa tgccaacctg tggttcaaca 2313361 ccgatttttt gctcgtgctt tggagtaagc tgactggagt gaatgaccca ttcaatatcc 2313421 tcaatcgtaa tgtcctttcg attctccgtt acagccatcc ccgctgcgat ttgaatcata 2313481 ttgacggctt cccgcccgtt ccgcgtgtag ctggtcaaaa gatccagtcc ttcttcggag 2313541 atattttttt caattttatc cgctgctgtt ttggcaaccg ttttcagctc gtccttttca 2313601 agctcgcgga aaaaaacctc caaacagcgg gaccggatag ctggcggaat ttcgtttggc 2313661 attctcgtgg tcgcgccaat caagcgaaaa tcagccggca gcccattttg aaaaatatca 2313721 tgaatatgat tcggaatttg tgtattttcc tcactgtaat acgcactgtc taaaaagact 2313781 tttctgtcct caagcacctt cagcatttta ttcatttgaa taggatgcag ctcccctatt 2313841 tcatcaataa acagcacacc gccatgggca tgggtgacag ctccctgctt cggctgcgga 2313901 atcccagcct gtcccatcgc tccggcccct tggtatatcg ggtcatggac agagccgatg 2313961 agcggatcgg caattcctct ttcatcaaaa cgggctgttg tcgcatcgag ttccacaaag 2314021 acagcctgct ctttaaacgg tgattgttta tgtttttttg cttcttccaa cacaagccgc 2314081 gcagcagccg ttttcccaac tcccggtggc ccatagacaa tcacatgctg aggatttggc 2314141 ccgcataaag ccgcctttaa tgctttaatg ccgtcttcct gtccgacgat atctttaaag 2314201 cttttggggc ggaccttctc agataatggc tcggacaagc tgatagcgcg cattttccga 2314261 agctgctcca tttccttctt tgattcttta tctatcgtga ccttttgtgt cctttgattt 2314321 ttaagcaaat tccaaaaata caaaccgatg atgatcccaa aaaacagctg aataaataac 2314381 gcgatccctg tccaactcat ggtggtccct cctgaaaaac aatttatgta tccaattcat 2314441 tcctctgatt gctagtatct cccatagaag acgggaataa acgtttttcc ggaagagttg 2314501 catgcaaaaa aacctcctga gtgttaccac tcaggaggtt tgtgcttatc tttatgcaga 2314561 tgttttatct tggcttacct cagtgccgtc ttttaataag aggcgaggag gctctccgtg 2314621 tgtcacagtt gccccggtga ttacacattt ttcaatgtca tcacgagaag gcagctcaaa 2314681 catcacatca agcatgatgc cttcaatgat agaacggagt ccgcgtgctc cagtcttgcg 2314741 ttcaattgct tttttagcaa tttcagaaag cgcttcttct tcaaactcaa gctcaacgtt 2314801 gtcaagctca agcattttct tgaattgctt aacaagagcg tttttcggtt ttgttaagat 2314861 cgcaaccaat gcttcttcgt caagcttttc aaggcttgca ataaccggaa gacgtccgat 2314921 aaattcagga attaacccga aacggagcaa atcttctgga agcacttttg aaagaagatc 2314981 ttctttctca agatcagcag ctttattgtc ggcaccgaat ccaatcactt tttggcctaa 2315041 acggcgtttg atgatttgtt cgataccatc gaaagctccg ccgcaaatga acaaaatatt 2315101 tgttgtgtca atttgaatga attcttgatg aggatgctta cgtccacctt gaggcggtac 2315161 gcttgccact gtaccctcaa gaattttaag caatgcctgc tgtacaccct cacctgacac 2315221 atcacgtgtg atagacgggt tttcagattt tctagccact ttatcgattt catcaatata 2315281 gataatgcct ttttcggctt tttccacatc ataatcagca gcttggatga gcttcaagag 2315341 aatattctct acatcttcac ccacgtatcc agcttcagtc aaagatgtag cgtccgcaat 2315401 cgcaaacggc acatttaaaa tgcgagccaa tgtttgcgcc agaagggttt taccgcttcc 2315461 cgtagggccg attaatgaaa tattactttt tgaaagctca acatcatcaa ctttgctgtt 2315521 ggagttaatg cgcttatagt ggttatacac agcaacagca agtgatttct tcgcttgatc 2315581 ttggccgatg acatattcat tcaaaatttc gcgaatttcc tgaggctttg gtacgtcttt 2315641 aaattctact tcttcttctg ttccgagttc ttcctctaca atttcagtgc agagttcgat 2315701 acattcgtca catatatata caccaggtcc agctacaagc ttacgaacct gatcttgtgt 2315761 ttttccacag aacgagcatt ttaattgtcc tttttcctcg ttaaatttaa acattctttc 2315821 accccttaat cttgtctcac tttttctttt accggcagag caaaagaaaa tgattcttga 2315881 aacgaacgag tatgtattgc attttaccat actttccaaa aagacggtaa caatgtgttt 2315941 ctgacttgca cattctatat gtatgacaaa aaacagccct gcattaacta tattgcccca 2316001 agaaaaagag ataactcata attgtacaaa acaaggcacg aatgattcgc gccctgtttt 2316061 attagtacta ttattatgca ccatattaac ggttttctac aagaaaatca attgctttgc 2316121 gaacttttaa atcttctttc atcgcgtcag tagaaccgat ggcttgttta atattttcaa 2316181 caggcatgtt gtatgcttca gccatttttg taagctcagc atcaacttcc tcatctgata 2316241 cttcaaggtt ttccgctttc gcaatcgcct caagagtcag gttagatttt acgcgttttt 2316301 cagcatcttc tttcatttgc tctttaagcg cagcttcatc ttggcctgag aattgagtgt 2316361 aaagctcaag gttcatgcct tgcatttgca gacgctgttc gaattctttc agcatgcggt 2316421 caagctcagt gtcgaccatt gcttgaggca catcgatttc agcattttca gaagctttca 2316481 gaacaagctc ttcacgcaat ttagcgtcag cttcgttttc ttttgcttct tctaaacgtt 2316541 tctttgtttt ttcagttaat tcagcaagtg tttccacttc ttcatcgata tcttttgcga 2316601 attcatcgtc aagctcagga agctctttcg ctttgatttc gtgaattttc actttaaaca 2316661 cagctggttt gcctgcaaga tcttcagcgt ggtactcctc agggaatgtc acttcaacat 2316721 ccttctcagc acctgcttca aggccaacta attgatcttc gaagccaggg atgaatgaac 2316781 cagaacctac ttctagagag tagttttcag cttttccgcc ttcgaaagct tcgccgtcaa 2316841 cgaatccttc gaaatcaaga acaactgtgt ttccttcttc aacggcgcct tcttctttta 2316901 caacaagctc agcttgacgc tcttgaaggg cttttagttc gttttgaaca tcttcgtcag 2316961 ttacagttgt gtcgtctttt tcaatgccca ggcctttgta ttcgccaagc ttcacttcag 2317021 gttttactgt tactttcgca gtgaagatta agctttcgcc tttttcgatt ttttcaacat 2317081 cgatttcagg acggtctaca ggctcgattc cagcttcttc aaccgcttta gggtattcta 2317141 caggaagaag aatatccaaa gcatcttggt aaagagcttc tacgccaaag cgctgttcga 2317201 ataatccgcg aggaatttta cctttacgga atccaggaat tgaaacttgt tttactactt 2317261 ttttaaatgc atcatcaagt gctgttttaa acgtttcagc atcaacttca accgttaaaa 2317321 cgccttcgtt gccttcttgt ttttcccatt ttacagacat gtgtttccct ccaaaaatct 2317381 attcaggttg tgtcggtctt ccattctaaa gcaatcattc ggcttcgtcc aacaaaaaca 2317441 aagctgccaa agatcagaat cattatgtat agatgttaat aatgaactgc aaagcctgtc 2317501 caaccgtatt tcttataacc cgttatacac aaatacaacc actatattat aacataacac 2317561 atagcgcttt caactatatg gcgcgattta caaataagaa atttcttcaa tatcttttaa 2317621 cattgtgcaa gcttcatcga gttctctgtc tgtaaattca tacatcatat gaagttcttc 2317681 gctttcaatt tcaatcccgt gcatctcgta accgacttta tgaagggcag ccgcccaaag 2317741 gtcagccgac agcaatttcg gctggaacgg atataaaacg tacaaatgtc ttctccacaa 2317801 ttcttctact gctgcatata aggttggatt ttcatttcca agtgtctcat ctagcaccct 2317861 gagaacacgg tgaagaatcg gcgcggcatc aggcggaaca atctctgacg gttcaattgt 2317921 caacgactcg ccaaatttac taatgtgtac aggtttactg tactcatgct cagccaacag 2317981 catgacaatc atcgttttga taatcggatg ggctgagggg tcttggagga ttgttttgag 2318041 caatcctgta tactttgcta cgttacggtc ttttaaggaa tgaatgagat tcatttgctc 2318101 ctcagggctt gccagcactt tctcggtgtc aattgtatcc tcatattctt cggcccaagc 2318161 ctcgtcctca cgatccggat cggtcatttt ccggctgaaa tccagcagct tataaaattg 2318221 ctcggcactt tctgccggca gctgattttc ttccaaaacg gcttcaatgg tgcttttgac 2318281 ttcttcgtac tttttgagct gaattaagat ggtcatgtac acctgcaaaa ccgtaaaata 2318341 atggccataa ccttctttga gcatcttctc gcacacgctt tctgcctctt ccagctcgcc 2318401 cagctctaaa aagcagatgg ccatccctaa gtgaagatcg gattcagtat catcatattt 2318461 catcgcttct gaaaacagtt caagcgcttc ttgatacttt ttttccttga gtgatgacat 2318521 ccctttttcc acaaggcggt ctttcagatg aggaaaagga ataatttttg cgtttttctt 2318581 gtcatgcgtc atacctatat tcctttcagg catttatttt gttcaagtgt atcaacacct 2318641 gtgaacaaaa acaagaaatg aaaggtttca ccaggcaaaa aaagccgccg gacaaatacc 2318701 ggccgctttt tcaggcttga agccaagagc ttctttgtga ttcaaattgc ttgatttcat 2318761 cttccagcag cagcgttaat gaaatttcat catatccgtt gatcagcatc tctttccaat 2318821 gcggatcaac ttcaaatgaa atttgattgc cttcactgtc atgaatcagc tgattttcaa 2318881 ggtcaacagt catttgcaat gactggtttt catactggcc gacaagctgt ttccaattgt 2318941 catatggcat gcggatcgga agcatgccgt ttttaaagca gttctgatgg aaaatatcag 2319001 cgaatgacgg cgcaatgata attttaaacc cataatcatc aagtgcccac ggagcgtgtt 2319061 cacgcgatga cccgcagccg aagttttctc ctgctattaa aatggaagct ccttgataaa 2319121 caggctggtt taattcaaat tcagggttcg gttcaccatt cgcatcatat ctccagtcaa 2319181 agaatgcaaa acgtccgtag cctgttcttt caatcctctt caaaaattgc ttaggaataa 2319241 tctggtctgt atccacattg atccgattta atacggctgc tttccccgta tgtgatttca 2319301 aaggttccat ctcgcgcact ccttacacaa ctgttttttc ctgataaaac tttctgacat 2319361 caacgaagtg tccgtgaatg gcagccatcg cagccattgc cgggctgacg agatgtgttc 2319421 ttgcaccttt tccttgtctg ccctcgaagt tgcggttaga ggttgatgca cagcgctctc 2319481 cctcaggaac aacatcatta ttcatactca aacacatgct gcagcctgac tctctccatt 2319541 caaatccagc ttccaagaaa atctggtcaa gcccttcttt ttcagcctga agcttcacgc 2319601 tttgggatcc gggcacgacg atggccctta cgctgtcagc taccttcttc cctttgatca 2319661 tgtcagcagc ctgtcgaagg tcagtcatgc gggaatttgt gcaggaaccg ataaatacgt 2319721 gctccacttt aatgtcttca attttttggt gaggagtcaa tcccatatat tcataagcac 2319781 gaatcgcttc ttttttatcg tcttctgcag aaaagctttc cggcgcagga acttcagaat 2319841 cgacaggaag aaccattccc gggttaatgc cccatgtcac cataggggaa attttgttgc 2319901 cgtcaaggac gatagattta tcgtaaacag cgcccgggtc tgtgcgcagc gccttccatt 2319961 cctctacggc cttgtcaaat tcttcgcctt ttggcgtgta cttgcgattt ttgcaatatt 2320021 caaacgtcac ctcgtcaggt gcaatcaaac ctgctcttgc tcctgcttca attgacatgt 2320081 tacaaacagt cattcgttca tccatcgtca tatttctgaa tacttcccca gtgtattcaa 2320141 tgacgtagcc tgtgccgaat ttcacaccgt atttgccgat gacagcaagg atgacatcct 2320201 ttgccgttac ccctttttga agcgttccat ctacgcgcac ttcaagtgtt tttggacgct 2320261 gctgccaaag tgtctgtgtg gaaaggacat gttcaacttc actcgtcccg attccaaatg 2320321 caagagcgcc gaaagcgcca tgtgttgatg tatgactgtc accgcacaca atcgttttcc 2320381 ctggaagcgt taagcctagt tcaggtccga cgacatggac aatcccttga tccacactgt 2320441 gaagatcggc aaggcgcacg ccaaattcct cacagtttct ttcaagcgcc gttacctggc 2320501 gtttcgcaac ttcatccttt atctcaaaac gattgacagt cgggatgttg tggtccattg 2320561 tcgcaaatgt gttttggggt cttctgacct ttcttccctt ttgtctcaag ccttcaaatg 2320621 cctgaggaga cgtcacctca tgaatgaggt gcaaatcaat atagagaaga tccggctttc 2320681 cctcaccatg ttttacaata tgctgatccc aaatcttttc gatgattgtt cgaggcatca 2320741 tcttttattt cctccctcta cctagagcta agaccgctta acgtaagctg tcacacatta 2320801 gaaattgtat tttcactcat gattgctgcc ttaacttcct ctgtaatggc ctgagtgctg 2320861 ctgaactctt cactccgtgc caagtctctt gttctttttc cagaagccaa gactttgttt 2320921 accgcatctt ctacagcttt cgcttcctct tcaagcccga aagatgttct caaaagcatt 2320981 gccgctgaca atatggctgc gaacggattt gccatccctt taccggcaat atcaggcgcg 2321041 gagccatgaa caggttcaaa cagatgaagg ccagagcttg ataggctggc tgacgggagc 2321101 attccgagcg agcctgtaag catggacgct tcatcgctta aaatatcacc gaacatattt 2321161 tcagtcacca cgacatcaaa ttgattcggt gcataaatta gctgcatggc cgcgttatcc 2321221 acaagcatgt gctcaagctt cacatcagga aattcttgtg caacgtcctc agccacttca 2321281 cgccacagcc ggcttgattc aagaacattc gctttatcta cagaggtcac tttgcctttt 2321341 ctggctgccg ccattttgaa gccctctctg atcactcgtt caatttccgt tcgcttataa 2321401 aacagtgtat ctactgcttc ctgctcacct tcagtgttta cataacgttt gctcggctgg 2321461 ccgaaataca agccgcctgt gagctcacga acgataacga aatcaacatt atctatatat 2321521 tcttttttca aaggcgaagc gtcagaaagg ctttcaaata ccttcacagg ccgcaaattc 2321581 gcaaacaaat caagctgttt tctgatgctg agcagccctt tttccggtct cagttccgaa 2321641 ggattttgat cccatttcgg tccgccgaca gcaccaagca atatcgcgtc tgcattttta 2321701 caagcagcaa cggtttcctc cgggaggggg ttatgatgtt catcaatagc cgcccctcca 2321761 atcaggccat attcaaattc aaattcatgg ttaaagcgtt cggcaacact tttcagtacg 2321821 tctgtcgctg attctaatac ttcagggccg atcccgtctc cgggcaatag agcaatacgt 2321881 ttcttcaagt taaccgttct cctttctttt atgatccgac agctgtgtgg tttttcaatc 2321941 cgctcatatt cgactggaaa accaattgac ggtttactgc gttcaaatag gctttcgctg 2322001 atgcttctaa tacgtcttgc gctatgcccc gccctgctga ttcttttccg ttcaccaaaa 2322061 ctcttacata cacctgggca aatgcatctt cgccttttct attagactga atgcggtagt 2322121 ctaagagctc cacatcctta tcgatgcagc gctcaagcgt attgtagatt gcttccacgc 2322181 ttccagctcc agttgcagct tcctgaataa gctgtgcgtt ttcttgattt ttcaaagata 2322241 gagtagccgt agggacctga cttgttccgt aatgtacttg cagagaaaga aattcatacc 2322301 caatcttgcg atctgttact ttttcttcta aaataagaga aacaagatcc tcatcagtga 2322361 tttctttttt cttctcagtc aactctttga acatcgtaaa gaatttatta atctcttcac 2322421 tgtcaaattg gaatcctaaa gcagtcagcc ggtctttaaa tgcgtggcgt ccggaatgtt 2322481 tacctaggac aagcgcatct gcggttacgc cgacaagctc cggtgaaata atttcataag 2322541 tcgatttttc ctttaaaaag ccgtcctgat ggatgcctga ttcatgagca aatgcattat 2322601 ctccaacaac cgctttgttg cgcgggacag ccatgcctgt cagtttgctt actaaatcac 2322661 ttgttctctt aatctcgttc agcgtaatac ctgtttcgac ttggtagaaa tcttttctgg 2322721 tatggagggc tacggcaatt tcctctaatg ccgcgtttcc ggctctttca ccgatcccgt 2322781 tcacagcgca ttcgatttga tcagcgccat tttcaatcgc agcaagagag tttgcgactg 2322841 ccattcccaa atcatcatga cagtgggctg aaagctttgc tttgtgaatg ttcggaacgt 2322901 tttctttcat atatttaaag atatttccgt attccgccgg ggccaggtag ccgacagtgt 2322961 ccggaagatt gataacactg gcgcctgcgt caatcacttt ctcgacgatt tctgctagaa 2323021 acggcagttc agtgcggcag gcatcttcag ctgaccattg cacaatcgga aaacgttctt 2323081 ttgcgtattt caccattcca actgctcttt caatgacttg ttcacgtgtc attttcagct 2323141 tgtgcttcaa atgaatgtcc gatgtcgcga taaatacatg aattcttggt tgagcgccat 2323201 cctttaacgc ttcccaagca gcatcaatat caccttttac acaacgggcc agaccagtta 2323261 ctgaacaatt tttaatggtt cttgcgattt cctgaacagc taaaaagtca cctcgggacg 2323321 aagcgggaaa tcccgcttca atgatgtctg ccccgagtct ttcgagctgc ttagctatgg 2323381 caagtttctc ctgtgtattc aagttcactc caggggactg ttcaccatca cgaagcgtcg 2323441 tatcgaaaaa attaattttg cgcaacggag accaccgctt ccttcttctt gccttgtttc 2323501 acaaacggca tcatttcacg aagctttctt cccactactt cgatttgatg ttcgttctcg 2323561 cttgcattga tagcgttgaa acgaggacgg tttacttggt tttcgacgat ccactctttt 2323621 gcgaatgtac cgttttggat atcttttaat acttctttca tagattcttt tactttggcg 2323681 tccacaacgc gagggcctga tacgaaatct ccccactgtg ctgtgtcaga gattgaatat 2323741 ctcattcctg caagtccttc ttcgtacata aggtctacga ttaatttcag ctcatgaaga 2323801 cactcgaagt atgcaagttc aggctgataa cctgcttcag ttaaggtttc aaatccggct 2323861 ttgacaagcg cgcttaatcc gccgcaaaga actgcttgct caccgaacaa atctgtttct 2323921 gtttcttctt taaatgtcgt ttctaatacg cccgctcttg cgccgccgat tcctttagca 2323981 taagcgaggg ctttgtctct tgcttctcca gtcacatctt gatagattgc gaacaatgca 2324041 ggtacgccag ctccttgctc atatgttctt cttaccaagt gtcccgggcc tttaggggcc 2324101 actaagaata catctacatc cgccggagga acaatttgat ggaaatgcac gttaaatcca 2324161 tgagcgaata ctaatgattt tcctgctgtc aattcatctt tgatttcagc ttcgtatact 2324221 ttttgctgct gctcatccgg aagcagaacc atgatgattt cggcttgggc tgccgcttct 2324281 tttactgaaa atactttatg tccgtcttct tgggcttgag tgaaagattt tccttgtcta 2324341 acaccgacga tcacgtctac tccgctttct ttaaggttca gggcatgtgc gtggccttgc 2324401 gaaccgtacc cgataaccgc tactgttttt ccagccaata cgttctcttt gatatcaccg 2324461 ttataatata cttttaccat ttcaatctct cccttgttat gttttataca atagatattg 2324521 ttttattgga tgacgccttt tgctgggttc ccctcgcaaa agccgttgta cctgttctcg 2324581 cgatttcttt aatgccataa ggttttaata actcaataag cgcttcaatt ttgttagatt 2324641 cacctgtcac ctgaacaacg atgctgtctc tgctgacatc aacgacagag gctctaaacg 2324701 gttctatgat tccattaatc tctgttcttg ttgaaggtgc ggagacaacc ttgattaagg 2324761 ccagctccct ctggacaatc gattgatttg tgatgtctgt gactttcagc acatcaatct 2324821 gtttgttgag ctgtttcgtt aactgttcaa catcattttc accttcaaca tgaacgacga 2324881 aggtgattct ggaaacgccg gctgtttctg tgtgtccaac tgtaatgctt tcaatgttgt 2324941 aatgcctttt tgtgaataga ccggtgatcc ggtttaacac cccggagcgg ttcaccacag 2325001 tcaatgtgat aattcttttc aaggtttcac ccccaccatt tcatgcagcc ctttccccgg 2325061 agccaccatc gggaatactt tttcttcgct ggcaacccgc acgtcaatga caacaggttc 2325121 tcttgatgtt aatgcctctt ccagcttttc ctttgcttcc gcttctgatg aaattctgat 2325181 gcctttaatg ccgtatgctt cggacaattt gacgaagtca ggctgagaag cgaatttaga 2325241 ttctgaataa cgttcttcat agaaaatttc ctgccactgt ctgaccattc cgagacaagc 2325301 gttatttaaa atcactacct tgaccggaag atttaattcg cgaataacat cgagttcttg 2325361 aagcgtcatt tggaatccgc cgtctccgac aaccgcgaca acagtagcat ctttttcggc 2325421 cagctgtgcg ccgatcgccg ccggaagacc gaatcccatc gttccaagtc cgcctgacgt 2325481 gacccattta tctgcttttt ggaacggata aaattgcgct gaccacattt gatgctggcc 2325541 tacatccgtt gcgacaatgg cctctccttt tgtaaattga tgaatatatt caatcaattt 2325601 ctgaggttta aaaccttctt cttcattatc tacataccag agcggatact cttctttcca 2325661 ttctgcgagc tgttttttcc attcgcttga atcgctttgt ttgccgtctt gtttgatcag 2325721 ctcctgcagg acaattttgc tgtctccgac tacaggaatc tgtgttttca tgatttttcc 2325781 gatttcagct ggatcaatat cgatgtgggc tatctttgcg tttctggcaa agtgtttcag 2325841 gtttcctgtg acacggtcat caaaacgggc gccgatactg attaatagat cacattcatg 2325901 aagggccata ttggctgtat aagtaccgtg cattcccgcc atccctagga aaagcggatg 2325961 gtcagccggg aagcctccga gccccaaaag ggtgtgtgcc acagggattt gctgctgttc 2326021 agcataattt tttaattctt ctgacgcttt tccgtgcagt acgcccgcac ccgccaggat 2326081 caccggtttt ttcgcactgc tcacggcttc cacaagcttg cggatctgca aataattcgg 2326141 ctctgttgtc ggctggtatc ccgggagatt catctcatga tcgtagctga attctccttc 2326201 aattgttgct acatctttcg gaatatcaat caatacaggt ccgggtcttc cagttgttgc 2326261 aatatggaac gcttctttaa tgatgcgcgg cagatcttcc ggctggcgaa cctggtagct 2326321 gtgttttgtt actggcatcg taatccctaa aatgtctgct tcctgaaatg catcgctccc 2326381 gattacagag gttgctacct gccctgtaaa gacgactaac ggcaatgaat caatcatggc 2326441 atcagcaagg cctgtaacaa ggtttgtcgc tcccggccct gacgtggcaa tgacgacacc 2326501 cggttttccg gagacccttg cgtatccctc cgctgcatga attgctcctt gttcgtgacg 2326561 gggaaggata tgtaccaacc ctgaattgta tagcttatcg taaatcggaa gcacagcccc 2326621 gcccggataa ccgaagatca tttctacttt ctcttttttt aatgattcaa tcagcattaa 2326681 tgctccgctc atcgtctgtg tacattcggc agatgctgaa tccacctgta cattagtccc 2326741 cattttagtt cctccttttg gattttcatc ctttaaagat catcttttca ttagctagat 2326801 agctgattat tcaataaaaa aagcccttcc gcccacaatc agccgcgcag taactgcgat 2326861 agctaaaagg ggcgaaaagg cttttctttc cgcggtacca cccttgttta cggcctgtta 2326921 atcggccgtc tcatggatat ttctatccgc tttagtaacg agtgaatcaa gttcacccgg 2326981 ccaagtccta ctgtcatttc agactggcac tctgaggcga gttcaccttg taaagcttcg 2327041 ccggttctca gctaacccgg ttctctgtgg aaaactttat caaggctact tatcctcatc 2327101 tgcgcttttc atattcagcc ttcggaacgg ctttccagct gttcaagaag gtcgtttgtt 2327161 tttcattttt ttagaatcat actgcgatga ttttcgcttg tgaagcttgc atttatcttt 2327221 tgttgaactc atattacgcc gctttggacg cagtgtcaac agcatttttt aaaattatta 2327281 gacaattttg attaatcaat ctatattgta tacgctttca ttattggtac aaaaggaatt 2327341 gcaaatgtta aaagttttta taattttttt attaatctat caagaataca ccagaattat 2327401 ttaattttat ataaacatgg aagattttat aacacgatat ggttcgtata tggattgagt 2327461 ctgacagatc atcttgcaat ccatttcaat ttcggatagg cacttctctt gttccctcgg 2327521 catacattaa tgatatcttg caaagaaaag gtgatacgat gaataaatca tttgcagaca 2327581 tgcaaggatt tcctgcgggc tttccaagct tccccaactt tccgcagcag tactatcctg 2327641 ctgtccctcc cttttaccag caaagccagc agccatttgg aggctacgga tacggacagc 2327701 cgttcagtca ggcatacagc ccgttaacca ctccctctgg aatgtactcc tcattcccat 2327761 acgcttcagg attttacgga cagcaatttt caggtgcagg ctttagcggc catggcggca 2327821 gcttaagtgc tccagcgata catgccggcg gattcagcgg ggcgccaggc gtacacggag 2327881 gctttagata ttaaagaata ccacaagggc cgaacatcta ttgcggtcct tttattgttt 2327941 taaaacgact tcacaagtac agtcacattt tctgtcttta tatttggaaa caggatggaa 2328001 tatgattaag atgaattgaa cgatattctg cacaatccgt aagttttcga ggaggaataa 2328061 aattgcatat aaaaatagac gatttaactg gacgtcaggt ggtttcactg gtgaatgagc 2328121 atttacatag catgacgctt atgtccccgc cagaaagcat tcatgcctta ggtctagaaa 2328181 aactaagagg gcctgaaata acattttgga gcgcatggga aggtgatgaa ctagctggct 2328241 gcggagcgct aaaagaactg gacacccggc atggagaaat caaatcaatg cgaacatctg 2328301 catcacattt aagaaaaggc gttgccaaac aagttctcca gcacatcatt gaagaagccg 2328361 agaagcgagg ctatgagcgg ttaagcttag aaacgggttc aatggcttca tttgagccgg 2328421 caagaaaatt gtatgaaagc ttcggtttcc agtattgtga accgtttgca gactacggtg 2328481 aagatccaaa cagtgtgttt atgacgaaga aattgtgaga cggctttata aggatagata 2328541 agtgcagggg aaggtctgtc ttatctatct ttttttatat tcacacattt ttcaccttta 2328601 tgatacacgc caatgttttc aattttgttt aattcaaaga acagcgggaa ttacaaacga 2328661 catgaacgat atcatgcaaa ttcataaagg aggagattga tatgaaaagc atagttggtg 2328721 tatatgaaac tccgcaggaa accatcgcag cgattgaagg cttacttaca aaaggctatg 2328781 attctgatga catttctgtt gtgacaagcc ggcgagatac agattatttg gagtcacgta 2328841 caggaacaga agtcaatcaa gctatcgatg cacatcagga cgaatctgaa tcttttttcg 2328901 ataaactgaa agattatttc acaatggatg atactgctac acacagcaaa gcattatccg 2328961 acttggatat taaaactgat gaaatagaca agtatcaaga agatttggat gacggaaaac 2329021 ttctggtagc cgtcgataca gatgcagatg taattgctcc tattgataac ggcaatgccc 2329081 tttcaggcgg cttttcaagc acaaatgaat tggattatac aacgaaagaa gaaaaaacga 2329141 tgccgctccg ggaagaacag ctgaaggtcg ataaggaaga cgttcaaacc ggcgaagtag 2329201 aaataggaaa agaagtgaaa acagaaaaaa gagatatgga cattccggtg agacatgatg 2329261 aaatttatgt cgaacgccgt ccagtggatg aaaataaaac ggacgctgct cccgtcaacg 2329321 attcggaaga gatcagagtt ccaatcgttg aggaaaagct ggaagtgact aaaaaaccgg 2329381 ttgtcactga tgaagtggtt gtcggcaaac gcactgttga agaaaatgaa catatttctg 2329441 aaactgtgaa aaaagaagaa cctcgtctga ataaagaagg aaaagttgac ggcttggatg 2329501 atgatccgtt aaataacaaa tgaaaatcat agaccgacaa caaaaaacct caaatcctaa 2329561 atggatttga ggtttttctt ttggtacgtc ccaggagaga ttcgaactcc cgaccgacgg 2329621 cttagaaggc cgttgctcta tccagctgag ctactgggac acgttttgtt tttttgtttt 2329681 tcgctttaac tatcagcgac aagatttatt atatatggga tgcaataata agtcaacggt 2329741 tttttagaat ttttttcatg aggaagaaaa ttttcttcct catgacattt tcatagtgtg 2329801 actcgatttt gcagatcctc aatttcattg cctgcttggt cgtaaaaacg gactgtcgca 2329861 gcatcatttt ctaatgtcag tatagcatag ctttctgtcc tgcgcaccct cggaagccgg 2329921 atgctgcctg ggttaatcat cagttttccg cgcagcactt cgcttcccgc gatgtgcgaa 2329981 tgcccgaagc agataacatc cgccccgagc tcctctgcac gatagtatac gtttaacaag 2330041 gtctgtttta taccgtgaag gtggccgtgt gtgactagta tttttcttga gccggcagtc 2330101 agaagaagct cgtccttaaa atcgccggca aaatcgcaat tgccttttac aaccgcataa 2330161 ggctccaatg caggatgcct cgtctcaagc tcagagtccc cgcaatgaat catgagatca 2330221 acttctgcct catgccgttt cgcaatggtt tggagttctt cttcaagccc atggctgtca 2330281 ctgataatca gcacgttcat gtacaagctt cctccttatg cctccaaaag cttagacagc 2330341 tttttaagcg cgtcagccct atggctgatt ttattttttt catcacttgt cagttcagcc 2330401 atcgtcttat ctttatcttt cacgataaaa attgggtcat agccaaagcc atattctcct 2330461 ctcggttctt cagcaatata cccttcaaca tggccttcga ctgtttttgt ttcctctccg 2330521 ggaatactca cggccagtgc gcagcggaaa cgggcggtgc gctgttcttt ttcgatacct 2330581 ttcagctcgc tgagcacttt ttcgatattt gcctggtcgt ctttctgttc ccctgcatag 2330641 cgggctgaat aaaccccggg tctgccgcca agattatcga tggatagtcc ggagtcatcc 2330701 gcaatcacca ttttgttcac tgctttggca acagcttccg ctttcataat ggcattttct 2330761 tcaaatgtat ggcctgtttc ttcaatttcc tctgtgaatc caatttcagc taaagatttg 2330821 acatcatagc ctcttggctc aagaatttct ttgaattcct tcacttttcc cggattatgt 2330881 gttgcaataa ttgcttcttt catgatgatc aagcctttct gtctttattt cagttctggc 2330941 agagaatcac ccagcacttc tttttgcttg tcaatcagct cttggattcc tttttccgca 2331001 agacccagaa gaccgttcag atcctctcta gaaaaagttg cctcttcccc ggttccctgc 2331061 aattccacaa aacggccgct gcctgtcatg atgacattca tgtcaacttc agcagaggaa 2331121 tcttcttcat aatttaaatc taacaaaatt ccctgttcct tatcaattcc aacagagatt 2331181 gcagcaagaa aatcagtgat cggatttgtc ttgattgttc ctgctttgat cagcttgcca 2331241 atcgcaatcg ccatagcaag aaatgcgcct gtaatggaag ctgttctagt tcctccatca 2331301 gcttgaatga catcacagtc aatccaaatc gtccgttcac cgagcttttc cagatctaca 2331361 acagctcgaa gcgcgcggcc gatcaggcgt tggatctcca ttgttctgcc ggaaattttc 2331421 cccttagaag attctctgat tgttctttgg tttgttgccc gcggcagcat gctgtactct 2331481 gctgtaatcc agcctttccc tccgccccgc aaaaacggcg gtacgcggtc ctcaacagac 2331541 gcgttgcaga ttacctttgt atttcccgct gttattagaa cagaaccttc cggatggctg 2331601 ataaaatcca aatcgaatgt gattggacgc agctcatcgt gttgtcttcc gtcatgtctc 2331661 atgttttacc tccgattgta tgtacataaa ccatttttgt cccggaattg aataaagaaa 2331721 gaggcagccg gaacgctaac ctctttcttc ctagtatatc aaaaatccca atttaaaaac 2331781 tacccgtatt cacttgagat ggtctggaga ccggttctgt gagcttttcg cctttttcat 2331841 ttaccagctc tgattttccg ttcactttaa cagagacgct ttttacatcc ggctgctccg 2331901 ttaacgtcag cacaatgctg ttcagcactt ctgaagaaat cattttcgtc ttctcatcgg 2331961 cgctgccgaa tatagattga ttgaaatcca acgtcacgcg cccgtctttg attttcggtt 2332021 tgctgaccag ctttacatct tcactgaagt ctgttaacag cccgctcacc ttgctcggcc 2332081 ctttagccaa ttcattaatg gctgctgtga tgtcgtcttt ttccgaattg tcgattcgtt 2332141 tggtcaccgg cacgtagtat tcactgtctt cattttccgc caaatagtag actgtcagcg 2332201 gatgggtagc agtgagatca tttacaccgg ctgtttccaa attaatgccg tctttgcggc 2332261 ttaaatcatc tgagatcggc gtccctccta caggcatctc cttcagttca tgcccgttta 2332321 ttctcagctt cactttatct atcgaactaa attgcgtcag cgtccacgtc acagattgaa 2332381 cgattttctg ttcgtcttct ttcttataat ttttgaactc attagagaaa tcagctatcg 2332441 ccgttccatc ttttttgatg tcaacgttaa cggtggtgtc agccggcaat acagctctga 2332501 agccattcgg aagaatttca gacacaggcc cgccctgtac gaggtattca agcgcctgct 2332561 tagccgtgct ctcactttta ggaagaggca gcgtttgcgc aacaacatac ccgtttttat 2332621 caatgagata aagctccctc ataacagtag atgaggcttg atccgctttt gcggtatcgc 2332681 ttttttcact ttctgttttt ttggctgctg ttgtatttga attggcaccc gcttcatcgt 2332741 tcacgaatgt aacgtcttga ggcggatcaa tttcctcggc tgccttatca gattgaaaca 2332801 aaccgcatcc ggataaaagc aaggcagagg tgagacaagt ggcaccaatg actgcaggtc 2332861 cttttttcag catacttttc cctcctaagg atgtttgtac tattatgtat acgagcctct 2332921 ttaggaaata gaccgaagaa ttccggcaaa acagaaaaaa acccgcaaca taccgttgcg 2332981 gggaaaacta tcttttaatc ggttcttgca gtgagataca ttccacatgc ccgacttcat 2333041 ggccaaacca atcgtctgcg atttttgcaa actgatcacg cgcccctgtt gtcaggaact 2333101 gatgatccgg ggcaatcgga gactggttca gcagcccttt ataagagaga attgtgctga 2333161 cttcccgggc tgtttcatcg ccggacgaaa taatgtttac gtgctctccc atatatcttt 2333221 gaatggcttc ttttaaaata gggtaatggg tgcagcctaa aatcagcgaa tcaattgatg 2333281 tgtcttttaa cggatacagc gaggttttaa caatctcgtc tgctgttttg tcgagaaact 2333341 tcccgctttc cacaaaaggc acaagcagcg ggcaggcaag gttttcaacc ttcaaatcag 2333401 ggtttaatgc caaaagcgct tcttcgtatg cattgctctt aatcgtattc tctgtgccga 2333461 tgacaccgat atgctgatta tccgtcactt ttatcgctgc tctcgcacca ggctggatga 2333521 ctccgaccac cggtataccg acgctgcgct ggatgtcatc caaagcgatc gctgttgctg 2333581 tattacaggc gatcacgagc attttgatgt ggtggttttc gagtaaataa ttcgtcagct 2333641 cccacgtata ttgaagcacc tcttcttcag ggcgcggccc gtaaggacac cgtttcgtat 2333701 ccccgacgta gataatattt tctttaggta gctgtctcat gatttccttc gcaacggtta 2333761 aaccgccaac cccggaatca atgactccta ttggttgttc caacaaaatc gcctcatttt 2333821 ctcttcattt catgctgcag tttcatcaaa gatttttcga agatggctat ttcttcatct 2333881 gtaaacgatt cgaacatatc acgcagatat tcctgtcttt ttgtaatgac ctcttggata 2333941 atccgttctc cttcaggcag cagatgtatc ctgacaacac gtctgtccgc cgggtccttg 2334001 acccgctcaa caagctcatt tttttgcatg cggtcgatta agtccgttgt cgtgctgcat 2334061 gccagataca ttttgcccga taattcaccg attgtcatat ctcctaattc ataaagccat 2334121 tgcaagccga caaattgcgg cggcgtaatc gcatattggt taaggatttc tcgtcctttt 2334181 tgcttaatga tcgcggcaat gtggcggagt gacttttcaa tatccgcaac atgctccaaa 2334241 ggttttgatg tcatttgtcc atccctcact caaggatctc ttacgcacaa aagcgttccg 2334301 tgtctatttt ccttcttttt tgaagaaaat gcaagactcg caggagagaa atagaggact 2334361 ttagtcaaac aacatcaaga aataaaattt aatttatgac ttgcctacgt tttgcacagc 2334421 attccaaata tggtttcgaa tgttccaaac aaacagcaat aaccggctcc ttccaaaaga 2334481 aggaataccg gcaaggatta aagctctagc tcacccattc taagaagctc aacaacggct 2334541 tgcgaacgcc ctttcacacc caatttctgc atggcatttg aaatatggtt tcgaacggtt 2334601 ttctcactga taaatagctc gcttgcaatc tcctttgttg tcttatcttg aacgagcaat 2334661 tcgaacactt ctctttctct tttcgttagc agcggcttcg attgaaattc tttctccttc 2334721 aagtattgta accctccttg ctaaggtgag agcgaatcag aaacgaatgg gttttgatat 2334781 agtcgagata tcatatgtaa gaagggcgca ggaggtgacg tttacaagat aattagttta 2334841 tcgtgtatga agaagcgttt ctttctcctc atccgtccag ctgacagcct tgccgctttc 2334901 ctttgagact tgaaccatca cgactgcccc ggtgaagcag ggttcgcctt cgaggttctc 2334961 tccgagatag tgcaaggtaa gagatgaact gccgactgcg cttgttttca catagatgcg 2335021 caactcttca taaggcatga cttggcgcaa ataatcgcat tgctggcttg ccacgactgt 2335081 catggtctgt ttgttttcac tcatcatatt cagcttttta aaataagaaa tccgcacctc 2335141 ctcaaaatat ataaaagggg ttacattatt catatgccca aacatgtctg tctcggaaaa 2335201 tcttacggat accttattga aaaaagaaaa ggatgttttc cattcttgaa acggcatatc 2335261 aatataagcg ggaagcttca tcttttttca tctccttatt gtttaaaaaa acctctccca 2335321 tgcggaagag gttttttctt cttatactct gtcgcttccg aagaaattgc ggaacgcttg 2335381 taagtttgta tctctattca aggctgcaat cgaagtggta agcggaatcc ccttcggaca 2335441 ggattgaaca cagttttgcg agttgccgca atctgcaagg ccgccttcat ccattaatgc 2335501 ttctaatcgt tcagatttat tcatggcgcc tgtcggatgc gcgttaaaca ggcggacttg 2335561 cgacatcggt gcaggcccca tgaacttcga tttgctgttc acattcgggc aagcttcgag 2335621 gcagacgccg catgtcatgc attttgataa ttcatatgcc cattgacgac gtttttccgg 2335681 cattctcggc cccggtccta aatcgtacgt accgtcaatc ggtatccacg cttttacttt 2335741 tttcaatgaa tcaaacattc tgctgcgatc aacctgcaaa tcacgaacga ctgggaatgt 2335801 tttcattggt tttaaacgga ttggctgttc aagctggtca ataagcgccg tacaagactg 2335861 gcggggtttt ccgtttataa ccattgaaca tgcgccgcat acttcctcaa gacagttcat 2335921 atcccatgtg acaggggttg tcttctcacc tttgacatta accggattcc ggcggatttc 2335981 catcagagcg gaaatgacgt tcagattcgg gcggtatgga atctcaaatt cttcatcata 2336041 aggcgtgctg tcagctgtat cttgacgtgt gataataaat cgtatggttt tttgttcact 2336101 catgattatt tcgccacctt cttcttcgag taatcccgtt tccgaggcgt tatcagtgat 2336161 acatcgacat cctgatactc aaattccggc gcttcatacg ggcttacatg tttagccatt 2336221 gttgttttga gccattcatc atcattacgt tcaggataat ccggtttata atgggcgccc 2336281 cggctttcat tacggttgta tgcgccaagg gtaatcaccc tcgcaagctg aagcatgttc 2336341 gagaactggc gtgtgaacat cgctccctgg ttgctccatt ttgtcgtgtc attgatgttg 2336401 atctttttga agcgctccat taactcctga attttgtcat ccgttttcaa aagcttgtca 2336461 ttatggcgga caaccgttac gttcgccgtc atccactcac cgagctcttt gtgaagaaca 2336521 taggcatttt cggttccgtc catactcata atatcagccc atttttcttc ttctttctta 2336581 acgtgagcgt cgaataaaga tgaagacatg tcttccgctg aagattctaa gccgtttaca 2336641 tatttcaccg cattcggacc ggccaccatg cctccgtaaa tcgcagacag cagggagttc 2336701 gctcccaagc ggttgccgcc gtgcatagaa taatcacatt ccccagccgc aaacagtcca 2336761 gggatatttg tcatttgatc gtaatccacc cataaaccgc ccatagaata atggaccgcc 2336821 gggaagattt tcattggaag cttacgcggg tcgtctccca tgaatttctc ataaatctca 2336881 atgatgccgc caagcttaat atcaagctct ttcggatctt tatgagacag atcgagatat 2336941 accatgtttt caccgttaat accgagcttc tggttcacac acacatcaaa tatttcgcgt 2337001 gtcgcaatat cacgcggcac caggtttccg tatgccggat atttttcctc caggaaatac 2337061 catggtttgc cgtctttata tgtccacacg cgcccgcctt caccacgcgc tgattcactc 2337121 atcagtctta gtttgtcatc gcccggtatg gctgtcgggt ggatttgaat gaattctccg 2337181 tttgcataat acgctccctg ctgataaacg attgacgcag cagatcctgt attaatcatg 2337241 gagttcgttg attttccaaa gatgattccc ggtccgcccg tcgccataat gacagcgtct 2337301 gaacggaagg attcaatttg catgtttgtc aggttttgtg caacaattcc gcggcaggtt 2337361 ctgtcatcat ctaaaacagc gccaaggaat tcccagcctt cgtattttgt gaccagaccc 2337421 gcaacttcgt atctgcgcac ttgctcgtcc agtgcgtaaa gcagctgctg tcccgtcgtc 2337481 gcaccagcat aagcagttct gtggtgctgt gtacccccga atcggcggaa atcaagcagg 2337541 ccttcaggcg tccggttaaa catgacgccc atccggtcta ataagtggat gatcgaaggc 2337601 gccgcttcac acatcgcctt gaccggcggc tggttggcaa gaaagtctcc cccgtatacc 2337661 gtgtcatcaa aatgttccca cggagagtca ccttcccctt ttgtattgac cgctccgttt 2337721 atgccgcctt gcgcacaaac tgaatgagaa cgtttgacag gaacgatgga aaacaattta 2337781 accgccattc ctgattccgc tgctttaatt gtcgccatga ggccggcaag acccccgccg 2337841 actacgataa tgcttgattg actcatgata gcccctctcc ctctagtaat ctagtactct 2337901 taaacaaatg caaaaatcgc ttttaagcct acgtatgaca gtgcaacaaa aataatcagc 2337961 gtaacgtatg tcgaaattct ttgagaacga ggcgttaccg tgatgcccca tgtaacagcg 2338021 aaagaccata aaccgttcga gaagtggaaa attgttgata aaacaccgac aatgtaaaaa 2338081 ccaagcatag ccggagagct caaaatattc gccatcatgt cgaaattgac ctcagcaccc 2338141 atttgtgcgg caatgcgggt ttcccacacg tgccagctga cgaaaatgag ggtgatgata 2338201 ccggttacac gctgcaggac gaatagccag tttctcatgt agctgtattg accggcgtta 2338261 tttttcgcag taaacgctat gtacacacca taaactgcat gataaattaa tggtaagaag 2338321 ataataaaaa tttccaaggc atacctgaaa ggcaggctat ccataaaatg agcagcgcta 2338381 ttgaatgctt cagcgcccct tgcggcaaac tggttgacga ctaaatgctg aataagaaag 2338441 atgccgaccg gtatgacgcc aagcaaggaa tgcaatcttc gaaaataaaa ctctctgttc 2338501 ccagacatta ctttaccccc tgtttgataa gtgcgaaatg tgctaaatct cttcccccac 2338561 ttctttcaat tgtaagcact ttattaagat ttattgacaa tttcatttta ctcctccctc 2338621 aaaagggcgt caagaaaacg cgtacataaa ttataatttt ccgaattgat tagttgattg 2338681 aaaaatttta ttttatcaat atatatttct tgcttaattt ttcataagaa ttacaggatc 2338741 attctgtaat cctcccccct gtttgagcta taatatacgc aggagagagg ggagacagat 2338801 atgaagtcta aatttgaagc atctattgac aacctaaaag aaattgaaat gaacgcttat 2338861 gcctacgaac taatacgaga gatcgttctc ccagatatgc ttggccaaga ttactcttcc 2338921 atgatgtatt gggcaggaaa acatctcgcc cgtaagtttc ctcttgaatc atgggaggaa 2338981 tttccggcct tctttgaaga agcgggctgg ggaaccctca ccaacgtaag cgctaaaaaa 2339041 caggagcttg aatttgaact tgaagggccg atcatttcca accggcttaa gcatcagaaa 2339101 gaaccttgct ttcagctgga ggctggtttt atcgctgaac aaattcaatt gatgaatgat 2339161 cagattgccg aatcatatga acaagtgaaa aagagagccg ataaagtggt tctgactgtg 2339221 aaatgggata tgaaagaccc agtgtaatca aaaaggcggt gactgcatag tcccgccttt 2339281 ttgattgtca ttacacagct gaagggtgtt ttgaaagctc aaatgcatcg tgaagcgact 2339341 cgactgcttt caccatgtca ttttcgctta cgactgttga cactttgatt tcagatgtgc 2339401 tgaccatttt gattaaaatg tttttttgcg ccagtacagc aaacatttca gccgctacac 2339461 cgggatttga gaccatgccg gatccaacaa tagatacttt agccaatttg ctttctgtct 2339521 cgattttctc aaattccagc gcgtctttat actcttcaag caccgcaacg gtttggtctg 2339581 catcttctgt tttgacagag aaggaaattc cagtcttgtc ctcggcctgc gtttggataa 2339641 tgatatccac gtttatgttt cttttggcaa gtgttgtaaa aatagtagac aaagttgtca 2339701 ggccgctagt cagcccgtaa atggttactc ttgtgatttg atcttcaaat gcaatgcctc 2339761 tgacaattaa attctgttcc atggatgatt cctcctcaat taatgttccc gcttcggttt 2339821 ctgtacttga acgcacttct aacggcactt ggtaattttt cgcgaactca actgctctcg 2339881 gatgaagaac accggcgcct aaattggcaa gctcaagcat ttcatcgtat gagatgccct 2339941 caagttttct cgctgatttc acatagcgcg gatcggttgt aaacacgcct ggcacgtctg 2340001 tgtatatgtc acatttatca gcttttaaag cggcagccaa agcaactgct gttgtatctg 2340061 aaccgccccg gcccaatgtc gtaatttcac aatcctctgt catgccttgg aatcctgcaa 2340121 caatgacaat ttttcctttt tcaagctggt ctgctaaaac cgaagtgtcg atatctgtaa 2340181 ttctggcgtt tccgtgaatg gcctccgtac ggattcccgc ctgccagcca gtataagaca 2340241 cagcgtcata gcctttttcc tgcaatgcca ttgaaaggag tgaaatcgtg acctgctcgc 2340301 ctgtcgccag cagcatatcc atttcgcgtt tgctcggctg gtcagaaata gcttttgcaa 2340361 ggctgaccaa ttcgtcagtg gattttccca ttgctgaaac gacgacaacg acttgatggc 2340421 ctttctgttt ttctgcaatt gcgcggtttg ccgcattttg aattttttcg actgagccga 2340481 cggaagtgcc tccgaatttt tgtacaataa gacccatgta ttaccaccct ttacattttg 2340541 gttcgtgcgg gtgaggagaa agagcgcttt gtccacaata aaaaaagcaa tgagaggaat 2340601 actctcattg cttatcaatt aatcatcata aatgattatg aacaacgaga tagccctcca 2340661 agaaaatgat ttcttgacag ccttacattt attcaatgca cggccagcaa ataataccga 2340721 tggggtttta tttgcttcgg cgacgctccc ctttcagcct ttttcacaga atccatcttt 2340781 ctccaaaggc atactcttga agttcgcacc tctatcttca ccatataaca cgatctaact 2340841 atgaaattag ttcacatttt atcagatctt atttaaaagg acaacattat ttttgcaatt 2340901 tgtcgtaaag gagctgagcc gccgctgcgg gaacaccggc ttttttgatg tcctcaaggc 2340961 ttgcttcctt cattttttta acggaaccga aatgctttaa cagcattttc tttcttttct 2341021 ctccgatacc cgggatgtcg tccaaaacgg attgaaacgc gctttttccc cggatttgcc 2341081 tgtgaaaact gattgcaaaa cggtgcacct cgtcctgaat gcgctgcagg aggtaaaatt 2341141 cctggctgtt tcgttccaga tacgccacct ccagcggatc accgatcagt aaatttgagg 2341201 ttctgtgttt ttcatctttc gctaaaccgg cgatcgggat atccaagccg agttcatttt 2341261 caatgacatc ccttgctgcg ttgatctgcc cttttcctcc gtcaatgata atcagatcgg 2341321 gcagcggcag attctcacga agcactctcg tatagcgtct tctgacaacc tctctcatag 2341381 aaccgtaatc atccggccct gtaacagttt tgattttata tttgcggtat tcctttttgt 2341441 atggtttgcc atcgataaac acaatcatcg cggaaaccgg gtttgtcccc tgtatatttg 2341501 agttatcaaa cgcttcaatt ctgtgcggcg tataaatatt taatgcctca cctagtttct 2341561 gcactgcccc gattgaacgc tcctcgtccc gttcgattaa agagaatttt tctttcaatg 2341621 cgattttcgc atttttatgg gcaagcatga gcagttcttt tttcgggcct tttttcggct 2341681 ggtgaacgtt tgtttccagt agctgctcga tcatagattg atctatgctg tccggaacta 2341741 aaatctcctt cggaaggaag tggttgtttt ttgaatagaa ctgcccgatg aacgtgagga 2341801 actcttcatc tgcttcctga taaagcggga acatgctgac atcgcgttca atgagctttc 2341861 cttggcggat gaaaaagacc tgcacgcaca tccagccctt atcgtacgcg tacgcgaaca 2341921 catcacggtc gactagatcg ttcatcgtca ttttttgttt ttccatcgtt gattcaatat 2341981 gggcaatttg gtcacgaagc tcttttgctc gttcaaactc aagattctca gcagcttcat 2342041 gcattttctc ttcaagctct tttttgacct cattatagcc gccccttaag aaacgtgtaa 2342101 tgctttcaac cagctctctg ttcgtctctt cggaaatatc ctttacacac ggagcaaggc 2342161 attggcccag atgatagtaa aggcacactc tgtccgggag cttggagcat tttctgagag 2342221 gatacagacg gtcgagcagt ttttttgttt cccttgctgc ctgtacattc ggatacggcc 2342281 cgaaatagcg ccctttgtct tttttgacat tgcgggtgac aatcagcctt gggtggcgtt 2342341 catgggtgag ttttatgaaa ggataggttt tgtcgtcttt gagcatgacg ttgtatttcg 2342401 gatcatgctt tttgatcaga ttcatttcta aaataagcgc ttcaagattg gaggacgtca 2342461 caatatattc aaaatcctcg atttccgtca caagcctttg ggttttcgcg tcgtgagaac 2342521 cggtgaagta ggagcgcact ctgtttttca gcacttttgc tttccctacg tagatcacag 2342581 tctgctgccg gtccttcatg agataacaac ccggttgatc aggaaggagg gcgagttttt 2342641 ctttcagttg tttgttcata tgttaccctt ccttatgttt aatcctttat ttccagttta 2342701 acacgaacgt ttgtttttct ctatggttca caattggcga ataaaaaaag cgatccctca 2342761 atcggaatcg ctctggcatg taagcagcgg aaaattaaag atgtttgttt acaagctctt 2342821 gaagcgcttc ttttggtttg aagccgactg aagtttcaac tacttcgccg tcttttaaca 2342881 caagaagagt cgggatgctc ataacgccgt attttccggc agtttcttgg ttttcgtcta 2342941 catcgatttt tacgattttc agtttgtctc ccatttcttg atccaattct tcaagaacag 2343001 gtgcaatcat tttacaaggt ccgcaccaag gagcccagaa gtctgccagt acgacgcctt 2343061 cgcttgtttc agctgagaaa gattgatcag ttgcttttac gatagccatt attgaattcc 2343121 tccaatgtga aatgatgatt tttagtatag catctcccat tcgttcacgc tattttaatg 2343181 cttacaaatt attttttcct gatcacagcc ggtttactca tttttatatg gttgaatggg 2343241 atatgctctt tttttaaaac acaaatctga taatggcccc gatcactaca attgccccaa 2343301 taatcattaa aatggtacga agcataagat cacatctcct cttcactgtc atgtacttta 2343361 ccatgccctg ccggagctgt tttaaaacct gaaaaagagc gccggcatga agctccggcg 2343421 ctcttgcgcg attaagaatc agcacgcagc gtaagtaaga cgactgacat tggcgggagt 2343481 tttactttca gtttgttttt gctgagcgtg tattgtctga aggattccgg tttgacatga 2343541 tgaggatcgt caaacgtgtt atgcgcattc attttttctg ccgtaagaat gactccggaa 2343601 tggtccgctg ccttgtgtag gcccctcagc tcgatttccg cctctgcttt gttttggtga 2343661 tcgatgttgc aaattgtgat attgatatcg ccttcagctt gtttcgacgc tgaaatgctg 2343721 atttgcggaa gcgtttcacc gttccattca tagtcggcag acattgtctc tgtggctaaa 2343781 agagaagcgt cctggtgcac cttaaacata ttgaatacat ggtacgtcgg tgtcaaaagc 2343841 atccgctctc cctcagtcaa aatcatcgct tgaagaacat ttactgtttg ggcgatgttg 2343901 gccatttgca cccggcggca atgctgatgg aaaatgtgga aatgagaagc cgccaccagt 2343961 gcatcacgaa tggtgttttg ctgatataag aaaccgggat tcgtgcctgg ctcgggatca 2344021 aaccacgtgc cccattcatc aataatcagc ccgacccgct gctccggatc gtaccggtcc 2344081 ataatcgtgc cgtgtttttg aatcaattca tcgatgtatt tggctttttt catcgtaata 2344141 aaccattcat cttccgtgaa ttctgtggct gatcctttgc ccttccagaa atcccccgga 2344201 atcgtgtaat aatgaagact caacccgtcc atcaggccag cggctttttt cataagcacg 2344261 tccgtccaat taaaatcatc cacatttgcg ccgcctgcaa ttttataaat gtcattcccg 2344321 ctgtaattgc ggacataagt ctgaaaacgc cggtacagat ctgcgtagta ttcgggatgc 2344381 atgttgccgc cgcagcccca gttttcattg cccacgccga aatatttcag cttccaaggc 2344441 tcttctcttc cattttgctt tctccagtct gacatcggcg tgccttcttc aaatgtcata 2344501 tactcaatcc actccgacat ttcctgaacg gttccgcttc cgacattgcc gcaaatatat 2344561 ggctcgcatt caagcagctc gcaaagcatc ataaattcat gcgttccgaa ttcatttgat 2344621 tcaattgtac cgccccagtg agtgttcagc attgtcttac ggtcaccgac accgtttgcc 2344681 caatggtatt cgtccgcaaa acacccgccc ggccacctaa ggacaggaat gtgcagctgt 2344741 ttgagcgcct ccagcacgtc ctttcgtatc ccgttgatat tggggatgtc tgagtccgtt 2344801 ccgacccaga tcccctcata aatccctctt cctaaatgct cagcaaaatg accgtatata 2344861 tttttgttaa tggttccttt tgcgatatct gtttgaatca ctgcttgatg ttcagacatg 2344921 cctctgatca ttcctttcat acggatatga aaagcaccac agtcaaatat gtgatctgtc 2344981 gtttgcctga ggagtcagca tgaatgtaag cgcttttaaa gtaaccatat tatatatgtt 2345041 cgtacatgtc aacgacattt tctattgttt ttatatttgt acgtatgtat ttataaatat 2345101 gaaaaaaccc ggacttttaa agtccgggat ttcctttatg agtgtatatt cagctgtttg 2345161 aattcctcag ttaataacgg gacaacttca aataaatcac cgacgatgcc gtaatccgct 2345221 attttaaaga tatcggcttc ggggtcttta ttgatggcga cgatcacctt gctgtttgac 2345281 atgccggcca aatgctggat ggcgccggaa atgccgcatg caatgtacaa atccggagta 2345341 acgactttcc cggtctgccc gatttggaga gcataatcgc aataatcagc gtcacatgcc 2345401 ccgcgagaag ccccgactgc ggcccctagc acctctgcaa gctcctgcag cggctgaaat 2345461 ccttccttgc ttttgactcc tcggccgccc gcaacgataa ttttcgcttc ggagagatca 2345521 acaccgtccg ccgttttttt cacgacctct tggataacag tgcggaggtc agtaagagaa 2345581 acatcaatgc tttcgatgct ccccgatctg ctggtgtctt tttctgaagc ttgaatgtta 2345641 ttggggcgaa ttgttgcaaa gatcatcgga tcggttgaaa tgacgcgttc aaaagctttc 2345701 cccgagtaaa tcggccgtgt gaacacaaca ttccctccgg taacgcttac atctatagca 2345761 tcagaaatta agcctgtttg cagacgggca gcaagcttcg gtgaaagatc cttgcccatt 2345821 gccgtatgcc cgaagatgac tgaatcagga ttttcttgct cgataacacc tctcatgacc 2345881 tggctgtacc cgtctgccgt gtatgttttc agcttcgggt cctcagcggt aagaacttta 2345941 tctgctccgt aatgaataag ctcttgtgca atgctttgta cattttcacc gatgagaaca 2346001 ccgatgactt ccccatctcc tgaaatggtt cttcctgcag ctattgcttc aaaggtgaca 2346061 tttcgcaatt ccccatcgcg tatttctcca agcacgatca ctttttttcc cattctaaca 2346121 tccccctgtt tctttgaatg tccaagtttt aaatgacttt agcttcgctg cggagcaatg 2346181 aaacaagctc ttttgcctgt tcagcaggct caccttggag aagcttcccg gcttcttttt 2346241 tcggcggcag aaaacgttca atggttttca gctttggttc agcatcctct tcgtccagat 2346301 caagatcatc aagttcaagc tcttcaagcg gctttttctt agccttcata attcccggaa 2346361 gcgatggata gcgcggctcg tttaagccct gctgagctgt gacaagcaat gggagcgtcg 2346421 ttttgatttt ttcaacatcc ccttcgacgt ccctttctgc ttctgcatca gtgccgttga 2346481 tttcgagttt ggtgatcgta gtgatacacg gaatgtccag tagctcggca agccgaggcg 2346541 ccacttgtcc tgatcctccg tcaatggcaa catttccgcc gagaatcaaa tcaaactcct 2346601 gatccttcat atagtggtat aaaacttgag aaatggaata ttggtcgggt tcatcaagat 2346661 catcttctat gttgattaaa acagcttggt cacaacccat ggcaagcgcc gtacgcaatt 2346721 ctttctccgc ttcttcaccg ccgaccgtga cagcggtgat cgtgccgcca tgcttttcct 2346781 tcagctggat ggcttcttct atcgcgtact catcatatgg attaatgatc cattccgctc 2346841 cgtcatcctg aatctttcct gtttcaatga cgattttttc ttctgtgtca aacgtccgtt 2346901 tcatcagtac aaatagattc atgatcatat ccccttttat tcgcctttga actgaggctt 2346961 tcttttttcg agaaatgcct ggatgccttc cttggcgtcc tctgactcaa atgcttcccc 2347021 aaatcgcttt gcttcaagct ttaagctgcc ttcataggaa tacaccttgt tggaataaag 2347081 aagttcaagc aaagatgcca gcgtttgcgg gcttttctct gcaaacttag cggcaagtgc 2347141 ttttgctttt tcaatcactt ctgcctcatc tttcgctcca attgagacaa gtccgagatc 2347201 aagcgcttct tttccggata tcggttctcc tgatccgatg agctccagtg ctttggctgt 2347261 accgacatat ctcggaaggc gctgtgtccc cgcaaaacct ggaatgatac cgagattaag 2347321 ctccgggagc cccagcttag catcttctgc cgcgattctg atgtgacagg ccattgcaag 2347381 ctccagcccg cctccgagag cagcgccgtg aatcgctgcg ataatcggtt ttggaaaact 2347441 ttcgattctc tccattaact gctggccgcg ctcagcgagc aatgaggaat cctcattgcc 2347501 tttaagcgat gtaaattctt taatatcagc gccggctgag aaaaatcttc cctcgccgtg 2347561 aatgataatg cttcgtacgc ctgcatctgt ctcacattga tcaagacagg aagacagctc 2347621 ttctaatatc cggcttgaaa gcgcgtttgc cggcggattg tgaatcgtca agactgccac 2347681 aaattgatca accgcaagtg aaattgcatt cataggacag aactccttta cttattgtga 2347741 attccggata ccaataattc taaaacgctg tttgaaagcg caacgagatc gtacttttgg 2347801 tcattcatca cccaagttgt cacagtttcg tcaatcgttc caaaaatcat ctgccgggcg 2347861 aggcggacat cgaggccttc ttttatttcg cctgattgta taccttccgt caaaatgcca 2347921 tccaaaatat ttaagtagcc ttttaatatt tcgttgattt tttggcgcag ctccaagttg 2347981 gattggcgga gctcaagctg cgtgacaatg gcgagattat ggtcacccgc taaaagggaa 2348041 aaatgctttg aaatcacaag cgccaatttc tctttcgctg ttgctttttc tttaatgtcc 2348101 tcttccatcc gctcaataaa ttgacccatt ttttctttga aaagagaaat taaaatatct 2348161 tctttgtttt taaaatagag atagatggtg ccgtccgcta ccccggcttg tttggcaatt 2348221 ttggatacct gtgactggtg gtagccgttt tctgcaatga cttctactgc tgcatcaata 2348281 atctgcatat actttggccg tttttgcttc aatgttcatc gttccttcct atagaaatga 2348341 atgactattc attcataatt tcatgataag aaggattttc aggtttgtca agtttattca 2348401 taggcgttct ctttttttat ttgatatgat gattttcggt ttcttcttca agtaaacgcc 2348461 ttcttaaaat ttttcccacc gccgttttcg gcagctcctt tctgaactca taggctttgg 2348521 gcaccttata gggagctaga cgtgatctcg caaaagcgtc cagttcttct gtatcggctt 2348581 ttgcgccttt ctttaatacg acaaatgctt ttactgtttc tcccctgtag gaatcgggaa 2348641 cgcctgcgac aacaatttcc tggatggctt catgttcata aagcgcttct tctacctcac 2348701 gcgggtaaat attgtaaccg ccggcaatga tgatatcctt cttcctgtca gcaatataga 2348761 aaaagccttc ttcatccata tagcccatgt ccccggtgaa cagccagcca tctctcagca 2348821 ctgcggcggt ttcctctggt ttattccagt atcctttcat gacttgcgga ccttttacaa 2348881 tgatttctcc atgctcatac ggagcggcaa gctcacccgt ctcttcagaa tagatcgcag 2348941 cgtccgtact cggccaagga cagccgatac tgcccggctt gttttttccc cagataaagt 2349001 tggcgtgcgt cactggggat gcctcagaca aaccatagcc ttccacaagc tttccaccag 2349061 tcaccttttc aaatttctgc tttacctcca cggggagcgc ggctgatccg ctaagacagc 2349121 ttttaatgga tgacagatca taatgctgca attcagggtg atgcaaaagg ccaatgtaaa 2349181 ttgtcggtgc gccaggaaag agcgtcggtt tgtgtttgtc gatgatttta agtgtttcga 2349241 gcggatcaaa cttaggaaga agaatcattt cgaagcctag tttaatcgaa tagttcatga 2349301 ctgccgtcag tccgtagaca tgaaaaaatg gaacgatgcc cagcactttt tcagcgcctt 2349361 ctttcacgtc atacatccaa gcggcgcaca tttcagtatt tgccaaaata ttttggtgcg 2349421 tgagcatgac cccttttgga gctccggttg ttcctccggt atactggagg acagcgatat 2349481 catgctcagg atcgatcttc gggattgtca ggagttcagt tttttcctgc ttcatacagg 2349541 aagcgaacgt gtgaatgtta gctgttttgt caaagtcgat atgcactttt tgtttttgcg 2349601 tcagcgggta aagaatattt ttcggaaaag gcaaatagtc ttttacactg gttatcaaaa 2349661 tctggtcgac tattgataac gttttcattt ttattgcctt cgggaaaagc aaatctaagg 2349721 tgatgattac acttacctga gcatctctaa gctggtattc aagctcatgc tcggtataaa 2349781 gcggattcgt ctgcaccacg atgccaccgg caaacaagac gccataataa gaaatcactg 2349841 tttgcgggca attgggcagc ataacagcca ctctgtctcc tttttgcagg ccattgcact 2349901 gcaaaaaagc tgcaagttta agagcatccg tcagaatgtc atgaaaggtg agtttttttc 2349961 cataaaacga tattgcggtt ttatcaggga atcgtgcggc ggagtctgtc aggatggatt 2350021 gcagggtttt attcggcaac ggaagctcat gcgggatatc gttgggatac tcggcaagcc 2350081 acggcttttg agactgcata aaacctcccc tttcgatttt agagatccac cttatcatta 2350141 tagcagatgg acggcaaaaa aaagaaaaag aaaggtaaat ctttcttttt ctcataatat 2350201 gaacagatat ataagaccaa ttaacaaaaa gattcccgct gcggcgagca gtattttcgc 2350261 aagcttttcc atctattctc cgtcccctta tattccggct gccaccacaa aagaaagccc 2350321 gacagaaatg acaaatgaaa taaagccgac agcccggtta tcattttcga tttcctgatc 2350381 aattttaaac cgcggagtca aaaactcaaa aataaagtag ctgatcagaa gcataacaaa 2350441 cccgtaaacg ccccagccga tcatttgcag cagcgaatta tgctgggaga tggaatgctg 2350501 aaatacgttt gcgattccca aaatttttcc gccggtcgcc attgccaccg caagatttcc 2350561 tttttgaatc tcttcccagt ttttataagc cgtcaccagc tcaaacacag tcaaaaagag 2350621 gacgaggcag agaaccgcga cactgtaata tgccgcgatt tccacaagct cgttttccca 2350681 aaaatcactc atggccatac tcccttttat tttagttcaa caaccgtaac gcctgatcct 2350741 ccctcacctg cttcaccgaa acgggaactt ttgacgctgc ggtggttttt cagaagatcc 2350801 tgtacgcctt ttcttaaagc gccggttcct tttccgtgga tgattgacac tcttggatat 2350861 ccggctaaca ccgcatcatc caagtatttt tcaacccggc tgagggcatt ttcatagcgt 2350921 tcgccgcgaa gatcaagttc aagcgatacg tgatagtcct ttcctttgac cgctgtaatc 2350981 attttttctt tttttggctc cggagctgat ttgataaact ccagatcttt ttcttttact 2351041 ttcatcttta aaataccgat ttgaacgttc cattcattgc cgcctgtttt ttcgagcaat 2351101 gttccttttt gcccgaaagt gaggactttc acctcgtcgc caggcttaaa gtcgcgtttt 2351161 tgcgttttcg gcttttccgg tttcttggac ttttcaaaag caggcatagc gccttctaac 2351221 cgtttcttcg cgttaatcag ctcgtgatcc ttgaaggatt tgtgttcttc ttttatggtg 2351281 cgcaattcat gaataatgtc ctcggcttct ttcattgccg cttttacttt ttcagcagcc 2351341 tgctgttctg cctcttcaag cattttgtct tttttgctgt taagctcgat gatttgctgc 2351401 tgcagctctt tatgcagttt ttccgcttct tttctgattg attctgtctc agaaagctct 2351461 tcttccgcac gttttttgct ttgttccagc gacgcaatca tcgtatcgac ttcgttatgc 2351521 tcggccgtca tttctgactt cgcctgcccg atgatatggt ccgggagccc gaggcgtttt 2351581 gaaatttcga aagcattgct tcgacccggc acaccaatta aaagtttata ggtcggtgac 2351641 agcgtttcga tgtcaaattc aacgctggca ttcatgacgc cttctctgtt atagccgtac 2351701 gccttcaatt ccggataatg cgtcgtagct aacactcgtg cattggtgcg atgcacgtca 2351761 tccaagatgc tcatggcgag ggccgccccc tcctgcggat ctgtccctgc accaagttca 2351821 tcgaaaagca caaggctgtt ttcattgacc tgttctaaaa tgccgacaat attcaccata 2351881 tgggatgaga acgtacttaa actttgctca atcgactgtt catcaccgat atcagcgaat 2351941 acgtgctcaa atactgccgc ttctgaccct tcatctgccg ggatatgaag acctgactgc 2352001 gccattaagg ttagcaggcc taacgtttta agggtgactg ttttcccccc ggtgtttggc 2352061 cctgtgatga caatggttga aaaatcgcgg ccaagctcga tgtcattggc aacaacctga 2352121 tcaggcggaa gcaatggatg gcgggctttt ttcaaacgga taaagccggt gtcgttcata 2352181 atcggttttg tcgctttaac cgcttttgca tatctagctt ttgcaaaaat aaagtcaagc 2352241 gtctgcagca cttgcaaatc tagaaatagc tcctctgtat actctgccgt tttctctgtc 2352301 agcacacgca aaatccgttc aatttcttgc ttttctttca ctttcgcctg ctgaagggaa 2352361 ttgttcatat ctacaatcgc ctgcggttca atgaatagtg tcgcaccaga ggatgaggtg 2352421 tcgtgcacaa ttcctccata gctggatctg tactcctgtt tgaccgggat cacaaagcgg 2352481 tcattccgaa tcgtaacaat cgtatcagac agcattttcg atgcggaaga ggaacgcagc 2352541 atcgactcta accggtctct gactcttgat tcgagtgttc tgagctgtgt gcggattcct 2352601 cttaatgttt ccgatgcatg atcaagcact tctccgtgat catcaatgca ggaattaatg 2352661 tcccgctcta aatcggacag cgtgataagc tgttcagcat gctgatggat cagcggaatg 2352721 tcgacaccgt cttcagccat ttgcgtgata aaatgtttca tttgtttaac tgcataaagc 2352781 aggcctgaga tttcagtgaa ttcagaagga ctgagaacgc tgccgatttc cgcccgtctt 2352841 aacgctcctc tgatatctac aaggccgcca aatggcgctt ggcctctcag ccggataatg 2352901 tcagaagctt cgtctacttc atccagctgt tttttgattt cgtctataga agcagaaggc 2352961 ttaagctcga gaagcatttc ttttccgagc gatgaagcgg catgcccaat aacctgttct 2353021 ttcactttat gaaattcaag agctgataat actttttgct gcacgattgt gtgagcctcc 2353081 ttacttaatc gttgcgcttc agaaatgcct ctacgtcttt aagcgaccgg gcattcagaa 2353141 cgtttttcgt ttccgtccat cctttgcgcg cggcagtaac gccagttttc atatcgtcta 2353201 acatctcaat attatgggca tcagtattaa tcaccaatgt aaccccttgt tcgtttgctt 2353261 tcattaaatg ctctgtgcgc agatcaaggc gcgcagggtt ggcattgagt tcaagcgccg 2353321 tatttgtttt cctcgcaagc tcaatcagct gatcaatatc gatttcgtaa ccggcccgtc 2353381 tgccgataag gcgcccggtc gggtgtgcga taatgtcaac atgcttgttt gtcagtgccg 2353441 tctcaagccg tttcataatc acgtgttccg gctgattaaa actggaatga atcgatgcaa 2353501 taacgatatc catttccgca agcacatcgt catcataatc gagcgtaccg tcaggcagga 2353561 tatccatctc aacgcctttc aaaatacgga agttttcaaa ctctgcattc agcgcgtcaa 2353621 tttcttttgc ctgctgctta agtctttctg cagtaagccc gttggcgacc tttaaatatt 2353681 gtgagtgatc ggtgatcgcc atgtattgat agcctttttt gatgcaggct tcagccatct 2353741 ctctgatcga aaatgcgcca tcgctccacg ttgagtgcat gtggagatca cctttgattt 2353801 gcccgagctc tatcagttca atgctgtcgc tgtaggtttc cacttcctgt ccgctttcac 2353861 gaatttccgg cggaatcagc ggcaggccga agtgcgcata aaattcacgt tcactcggaa 2353921 atgttttgat ctctccggtt tcaactgtct caacgccgta ttcactgatc cgctcgccgc 2353981 gttctttggc gatttggcgc atcttaatat tgtgatcctt tgatcccgta aaatgatgga 2354041 gtgttgtcgg aaactgctct tccgtcacaa gacggaaatc gacgcttgtt tcatattcaa 2354101 aggaaaggat gacggacacc ttcgtatctc cgcttgcgat cacgcttttg atgtttggca 2354161 gctcaagaag ctgctctctt acttcagccg gatgatctgt agcaatgata taatccagat 2354221 ccttcaccgt ttcccgcgct ctgcggagac ttccggcacg agaaaatttg atgatatgcg 2354281 taaattgaga aagatgctcc tcaatttccc gcgcgatccg gagggcgtag ccgatcggga 2354341 accgttcagg ctgttttccg gcttccccga gcgcctgtaa tattttttct tccgattttt 2354401 tgccgaagcc cgcaagaccc tggacctttt gctgctcaca ggcttccttc agagattctg 2354461 catcgtgtac gccgagctct ttatacagct ttgcgatttt tttgccgccg agccccggca 2354521 gcttcaataa aggcacgagt ccttccggca cttctttctg aagcgattcg agcgtgcttg 2354581 actttccttc atctatatac tctttaatga cgctgtacgt tccttttcca atgccggaca 2354641 gcgacatcat atcgtccatt tctgataagc ttcggtcgtc ctgttccaga gctgccgccg 2354701 cttttcggaa ggcggatact ttaaacgggt tgtccccttt gagttccata tagactgcaa 2354761 tggtttcaag cagccggata atatcttttt tatgcatatc ataaccccca gacgttcaca 2354821 tatgtttcca tcatacttga aaaaaacttc tccggacaag agaagttttt ttatgccccg 2354881 tactgtgtcc acagctcttg taaaagccct gacaagtacg gtgtatggtt aatgatcaca 2354941 tttgcgagag acgattgccc catcatttgc tgcaacgcgt ctaccggcag aacggatgcg 2355001 acatacagca gcacaaatgt aaataaatag acttctagaa aaccgagaac ggctcccagc 2355061 atctggttga tttgtttaat caccggaatg ccggctacaa tactcaggaa cgagccgatg 2355121 attctcagta agattttagc aatgataaat aaaacgataa acgcaatcgc attatagtac 2355181 gctgcttcca aattccccgt aaaaaaagaa agagccggct gtcccgctga aaaatcgggt 2355241 gcgggaatcc aatgtaaatg cggtgccacg tttttataga ataaagccgc aaaggcaatt 2355301 gataaaataa agctcgtcaa gcggataaac tgcaggataa aaccgcgttt taaccccagt 2355361 aaagtcccca tcaggagcaa gattaagatg atgatatcta gcatagttgt tcaatccttt 2355421 tctttaagct gacgctccag tttttcacat ttctcttgta atttgacata atcgtgcacc 2355481 acatttaccg ctgtcagcac tgcaagttta tttatatcaa ggtatggatt tttttcattg 2355541 atttctctca ttttatcatc aacaattccg gcgacatacc tcatatgggc tctgctttct 2355601 tcaccgacaa tcgtgaagtg ctggccgtaa atgtcaacgg ttgtttttgt ttttttgccg 2355661 tcagacaacg tttctcctcc attccgcgag aatcctagtt cttatcataa cacgtttatt 2355721 aaatgaatgg aaagacgagc ctcccgctgt tatgatacac tggtatatac agcgaaaagt 2355781 gtaaaaaaag gagattatta cgtgtcccat tcagtgataa aagtatcgtt gtctgctatt 2355841 gaccaaatga aaatgacgta cagcggttca cttacagcct ctgttccgca gggagccgtt 2355901 tttcaggcaa aaccgcccgg ctgtaccatt acagcatatc aatcaggtaa ggtcttgttt 2355961 caaggaaaaa acgctgcggc agaatccgcg cgctggggaa cagcagagcc tcaggaaaag 2356021 aagaaaacgg ccaaaaagcc ggctgatccc cgctatgccc ctccggcaga tatcgccgga 2356081 atgtctgtta tcggttctga cgaagtcgga accggagatt actttggccc aatgacggtt 2356141 gtatgcgcgt acgtcgacaa aaccatgctt cctttaatga aggaactcgg tgttaaggat 2356201 tctaaagatt taaaagatcc gcaaatcatc gagattgccc gaaacctgat taaaaccatt 2356261 ccgtacagcc tgctggtgtt aaagaatgaa aagtataaca gcatgcagga aaaaggcatg 2356321 agccaaggga aaatgaaagc tttgctgcac aatcaggcga tcacacattt attaagaaaa 2356381 ttggatggag taaagcctga agccattttg attgaccaat tcgctgagcc aggcgtctac 2356441 ttcaatcatt taaagggcag agacattgtg aaggagcgga cctattttag cacaaaagct 2356501 gaaggtattc acctggctgt cgccgctgct tcaatcattg caagatattc atttttaatg 2356561 gaaatggata aactatcacg cgcggcagga atgacgcttc caaaaggggc cggtccgcac 2356621 gtcgatgaag cggccgccaa gctgatcctc aaaaaagggg catctgcact cagaaccttt 2356681 acaaaactcc atttcgccaa tacgcaaaaa gcgcagcgcc ttgctgataa aaaacgttca 2356741 tagaaaaaag cttgcagatt tctctgcaag cttttttatc agcctcttaa aacagcttga 2356801 tatgtgtctt ctaacgcttt cagcactttg ctgtgcgcct ttgtcacttc ttcttcagtc 2356861 agtgtttgtt caggattgac atactggagt gagaaagcga ctgacttctt gccttcctcc 2356921 atatgctctc cttcgtatac gtcaaatacg gttacctctt tcagaagctt gcccccggcc 2356981 tctttaatga cgctctcgag ctgtccgctt gtgacggttt tatctgttac aagagcgata 2357041 tcacgtgtca cagacggata ttttggaatc gccgtgtaaa caagcggtgc tgtttctgct 2357101 gcgagcaacg catgaagatc gagctcaaat acgtatgttt cctttatatc cagttctttt 2357161 tccaatgaag gatggacttg gccgatgaag ccgatcagag aaccattcaa taaaatgttc 2357221 gctgttctgc ccggatgcag ctgtttgcgt tcagactgta caaattcaat gctgtctagg 2357281 acgttgagtt tgtctaacag cccttccaca attcctttga caacaaagaa atcaactggt 2357341 ttcttttcac cctgccatag ctgcttgcgc cataatccgg taacagctcc tgctacgcgt 2357401 tctgtttcaa caggttttgt gtcctcttcc ttcgttagga aaacggagcc aacttcgtac 2357461 agtgcaactg agtcagtctg cctcgcaaga ttgtaagaaa cagaatcaag cagatttgga 2357521 acaagactgt gtctgagaat gcttctttct tcactcattg gaagcgcaag cacagtattc 2357581 agtgattttt caatcgcaaa cgctgtcgct ttcttctcgt ttgtcagtga gtaagtgatg 2357641 gcttgtgata agcctgcgcc ttcaaggaag cgtctgactt tacggcgttt tgcctgatat 2357701 ggcgttaatc cgcctgtagt tcccgctgtc tcaggaagcg tagacggaat gttatcgtag 2357761 ccgtacagtc ttgccgcttc ttcgattaaa tcctcttcta ttgtaatgtc accgcgccgt 2357821 gatgggacag tcacaacgag aagatcatcc gcttcaccga ccgtaaaacc gagacgttta 2357881 taaatgctga tcagttcttc tttactgatc gtcaggccta gaacgctgct cactttgtca 2357941 gcagatacgt gaatgttatt tgcttcgatt gtcaggtgat cttcctcaac cgttccagca 2358001 agcacctcac cgccggcata cagatggatc agctgcgcag cccgttctgc tgcaagacgt 2358061 acgcgtgccg gatcaattcc tttttcaaat cttacgcttg attcacttct caaaccaagg 2358121 tctttggaag ccttgcgaac cttctgcccg ttgaaatacg cagcctcaag caaaatggtt 2358181 ttcgtatctt cctgaacctc tgactctgct cctcccatga caccggcaac ggcctgcgct 2358241 ttcgttccgt ttgtaatgac aaggtgatcg gcagacagct tacgttcttg atcatcaagt 2358301 gttacgatca tttcattctc agctgctttt cttactacga cttccttaga gccaaatctg 2358361 tcataatcaa acgcatgaag cggctgtccg tattccaaca ggacaaaatt tgtgatgtca 2358421 acgacgttgt tgtgcggacg aatgcctgca ttcatcagct ttgtctgcat ccaaagcggt 2358481 gacggagcaa tcgtgacatt tttaatgatt tttgcagtgt acagcgggtt cgcttcttga 2358541 tcttcaattt tgactgaaat gtaatcagac gcttgttctg aagcagccgg gtaatccgtt 2358601 tgcggaagct ttacctcagt gtctaaaatc gccgcaacct cgtaagcaac accaagcatg 2358661 ttcatggcat ccgcgcggtt tggcgttaaa cccagctcaa gaatcgcatc gtcaagctgt 2358721 aaagccgcta aggcatcgct tcctgtttca gcgtcattcg ggaatacgaa aatgccttct 2358781 gcatactcct tcgccacaag tttgctttcg ataccaagct cctgtaagga acagatcatg 2358841 ccgtttgatt cttcaccgcg aagcttggct tttttgattt tgaaattgcc cggcagcacc 2358901 gctccgactg ttgcaactgc gactttttgt cccttatcca cattcggcgc gccgcaaatg 2358961 atttgtacag gggcttcagc tccgatatcc acaaggcact tattcagctt atcagcattc 2359021 gggtgctgct cgcgctccag cacatggccg atgacaacgc ctttgatgcc ttctcctttg 2359081 tattcaattc cttcaacctc aataccggct cttgtaattt tttcagcaag aacagccggg 2359141 tccatgcctt ttaaatcaac ataatcctct aaccatttat aagaaacaaa catccttgca 2359201 tcctcctctt acgcctgttt aaactgcgaa ataaatctga catcgtttgt atagaagtgg 2359261 cggatatcat caatgccata tttcagcatc gcgatgcgct caacacccat tccgaatgcg 2359321 aagccctgat attccttcgg atcaaagcca gccattttaa gcacgttcgg gtgaaccatt 2359381 ccggcaccga ggatttcaat ccagcctgtt cctttacata ctgagcagcc gttcccaccg 2359441 catttaaagc atgtcacatc cacttctact gaaggctcag taaacgggaa gaagcttggg 2359501 cggagtctga tttcacggtc ttgcccgaac atttttttcg caacaagttc aagcgttcct 2359561 tttaaatcac tcatgctgat gtttttgtca acgacaagcc cttcaatttg cataaattgg 2359621 tgagagtgcg tcgcatcatc gttatcacgg cgatatactt tacccgggca aatgatttta 2359681 acgggacctt tgccttcatg cttttccatc gtacgtgttt ggacaggaga agtttgcgtt 2359741 ctcatcaaag tttcctctgt gatgtaaaag ctgtcctgca tatcgcgcgc tgggtgttct 2359801 ttcggaagat tgagcgattc gaagttgtag taatccgttt caacctctgg cccttcctcg 2359861 actgtgtagc ccataccgat aaataaatct tcaatttctt caatgacaac agtgagcgga 2359921 tggcggccgc cgactgcaac agggttcccc ggcagcgtga cgtcaattgt ctgtcctgca 2359981 agcttctgtt tcatttcctc ttcttcaagc ttctcgtttt tgtcagcaat cgcattggca 2360041 atacgctccc ttacttcgtt cgcgagcgcc cccatttttg gacgttcctc agcagaaagc 2360101 ttgcccattc cgcgcagcac ttctgtaatc ggcccttttt ttccgagata ttgcacccga 2360161 atatcattga caaccttcaa tgagcttgcc gcttctactt gttctaaagc ttcttgttcc 2360221 agctgtttta gcttttcttc cattttgcat cctcctttta tgtaaacaaa ccgtcatatg 2360281 tctttggaaa ataaaaaaaa cccgtccctt gtacaaggga cgagttgtgg ccgcggtacc 2360341 acccttattt cagacagact gatgctgtcg tcagcttcat tgacataacg gaatcagatt 2360401 ccggttcacc tttacgcgca gtgtacgcgg tcccggcgac aactcaagag gtgaagccaa 2360461 tttccggctg cgttaaaaat gctctcagtc agcggcattt tctccctgga aagcagttga 2360521 tcagaaattg aggtcctctg tcacggtttt tgaaatatta tgttctatta tagagaaatc 2360581 caacgcttgg cgcaacacta tcctcgcaag tgatacacga ggatggcagc cgcaaccgca 2360641 acgtttagtg attcagcctg tccgtaaagc ggcacgtaca ggttcaaatc cgttttttcc 2360701 agcaatgcag catctacccc tgcaccttca tttcctacaa tgagcgcaaa ggattcagac 2360761 tgaggaatct cctggtaagg cgctccgttt tgcagcgccg tgccgtatac ttttacgccc 2360821 tctgccttca attcgtccac atatgaaggc aggtttcttc tcacaacagg aatatggaag 2360881 tgagatcctt gagcagatcg cagtgttttt ccgttaaagg cgtccgccgt gccgtcaccg 2360941 agtacaaccg catccaaacc ggccgcatca gccgttcgaa tcattgtgcc aaggtttccc 2361001 ggatcttgaa cagcgtcaat cagcagcacc ttgcgtgccg ttgccagctt ttcttcaggc 2361061 atatggcaca cagcggcaat ctgctgcggc gtttcggttt cagtcacagc tgaaaacgca 2361121 tcttcactca gcatatagca ctggatacca gtctcaagat ctgaaggaat cctcgtttca 2361181 tcctttacaa ggatttcttt cacaatgccc gggcttttca acgcctcttc aacgaggtgt 2361241 tctccctcta tcagaaatgt atttgttttt gttcgttctt tttttgtgtg aagctttttc 2361301 caatccttca ctttttggtt ttttgccgat tctatttgtt tcactgtcta tgtggcgctc 2361361 ctttttttaa catgatgtta ttatatcgca agaacagcac ataataaacc aggtgcaggg 2361421 ttagaatata cgtattacat tttagaaaaa ggagcgtttt acatggatct taatttacgt 2361481 catgccgtca ttgccaatgt caccggcaat aatcaggagc agcttgagca tacaatcgta 2361541 gatgcgattc aaagcggtga agaaaaaatg cttccagggc tcggcgtttt attcgaagtc 2361601 atttggcagc acgcatccga aagtgagaaa aacgaaatgc tgaaaacgct tgaaggcgga 2361661 ttaaaacccg ccgaataaga catgaaaccg ggtgacagcg cccggttttt ttcttatata 2361721 ataaaaacat gatgaggggg aacgccatgt ttttacagcc gttattagcg aaaaaaatta 2361781 ttgctgaagt taaaaaaatg tacgaacgtg aagtcattat tgtaaacacg gacggtctta 2361841 ttatggcagg cacaaacgat gagcgtgtcg gacaatttca tgagggagcg cttatctgcg 2361901 caaaagaaag acgcagcgtg attattacaa aagaagatga aacaaggtta aaaggagtga 2361961 aagcaggcat aaacctccct gtattttttg accatgatgt gattgccgtc ttcgggctga 2362021 caggtgagcc tgcagagatt cagccattcg gagaactgct tcgaaaaatg acagaactgt 2362081 tcattaagga atcgcggcac ttagagcaat cccagtggcg tgagagaatg ctggagtcct 2362141 ttatgatcga ttggctgcaa ttaaaggagt ggtctcccag ttttcttgag aaagctcagc 2362201 ttcttggtgt tgacctttct tcccggcgcc aaatgattct tattcagggg tatgagtggt 2362261 cacctcatga tattgaacaa atggcacgca gctggaaatc ctcgtaccct gcggatttgt 2362321 tcatcaggtg gggaaatgaa cggattttga ttaatcatga agtgccgcag catgaacaaa 2362381 gggatcggct tttgcggaaa atccttcaca tttgttcgtt tgccaatacc gcaagcagcc 2362441 aatatacagc agctggcgcc ggaagggctg tcgcaagctc cagcctgaca gattcatacg 2362501 agcaagcgga aaaagcgctg gctgtcagcc ttaagcgaaa aacgcccata tttgaagagg 2362561 atctgaagct tgatatgtgt ctgacggaga tcagcccggg aacccgaaac gaatttccgc 2362621 aaagagtatt aggaaaggcg ctagagcatc aggaacttat gaatacgata cggactttct 2362681 ttcatcacga tttgtctttg aaacaaaccg ctgaagacat gcatatacac atcaatacat 2362741 tgcgttatcg tctggctaag gctgaacagc tgacgggatt acgttttgac cgtaccgagg 2362801 acgtcgtcac gatgtacgtc gcactctatt ttttagatca agatacaaaa tagagagagt 2362861 ttcagtttca ttttttgtat gtttctccat ggaaggcttt gctttttttc ttttacaata 2362921 gattgaaagc gttttttgac agggggatgg gtgaaatgat caccaaggat gtaaaggagc 2362981 agctgattca ggtctccgga ccagaaaact ttgatgactc gaatgccggc cgtctcgtct 2363041 attcatatga tgcgacgcct cagtatcagt ctatgcctga tgccgtgatt gctccgagga 2363101 atactgatga aatatcacgc attttaacaa tttgcagcga acatcgagtg ccgatcgttc 2363161 caagaggatc agggacaaac ctgtgcggcg gcacgtgccc gactgaaggc ggacttgtgc 2363221 ttctctttaa gcacatgaac cagattcttg aaattgatga agaaaattta actgccacag 2363281 ttcagccggg cgtcattacg ttggatatga tccgggcagt tgaaagcaaa ggtttatttt 2363341 atccgcctga cccgagttct atgaaaatat caactatcgg gggcaacatc aatgaaaatt 2363401 ccggcgggct acgcggatta aaatacggtg tcacccgcga ctatgttatt ggactggagg 2363461 ttgttctcgc aaatggtgac atcatccgca ccggcggaaa actcgcaaag gatgtggccg 2363521 gatacgatct cacacgtctt tttgtcggct cagaaggaac actcggcatt gtgacagagg 2363581 caatcgtcaa actcgttcca aagccggaaa caaagaagac gctgcttgcc ctttatgaaa 2363641 acatcgatgc cgctgctcaa acggtatcgg acattattgc cgcaaaaatt atacccgcta 2363701 cgcttgaatt tctcgatcag cctacactat tggtgattga ggattatgcc aaaatcggac 2363761 ttccgacaag cgcaaaagca gttctgttaa ttgaacaaga cgggccattt gaaactgttg 2363821 aacgggatat ggaaaagatt gaggcgatct gcaaaaaagg cgacgccgta tccgttcaga 2363881 ccgcacaaac agaggaggaa gcgtttgccc tgactgaagc ccggcgttct gcactttctg 2363941 ccctagcccg cctcaaaccg acgacgattt tagaggatgc gaccgttcct cgctcagaaa 2364001 tcgccaatat ggttaaagcg attaatgata ttgctgctaa atatgatatt tccatctgca 2364061 cctttggtca tgcgggagac gggaaccttc acccgacatg cacgacagac ataagaaata 2364121 aggatgaaat ggaacgtgtc gaacaggctt ttgccgagat ttttgagaaa gcgattgaac 2364181 ttggcgggac gataaccgga gagcacggag tcggggaaat gaaagcgcct tacttggaaa 2364241 tgaagctgaa aaaagaaggc attgatgcga tgaaagcgtt gaaagcggca tttgaccccc 2364301 ggaacatatt aaatcccggc aaaatgtttg cgaaagatgc cagaaaacgt gtggtggcgg 2364361 aaagatgaca acagaaaaag aaatgaaaca gatccaaaat gaatttaaag agcgtatgga 2364421 tgaaggagag ttattaaatt gtatgcgctg cggcttctgt cttccttcct gtccgaccta 2364481 tatcgaatcg ggatttcagg aaacacactc tccgcgtggg cgcatcgcct taatgaaagc 2364541 cgtagccgac ggtatgattg aaccggatga agatgtcgaa cggtcgctgt cactttgcct 2364601 cggctgccgc gcctgtgagc ctgtatgccc gtctggcgtg aaatacgggc agctgcttga 2364661 ggaagccaga gatattatcc accaaaataa aaaacactct cttggtgaac gtgtcatgcg 2364721 aaagacggct tttcacgagc tgtttccgca tcaaaaccgc atgcgctcag ctgtaagcct 2364781 tatcggtttg tatcagcgtt caggactgca aaccgctgtg cgaaaatcag gcatgcttcg 2364841 ggtcctgcct gagcatttgc ggacgatgga agctgttctt cctgatgttc caaaaagcaa 2364901 agacatgaaa catcggccgc gtttcctgcc ttccattggc cccatgaaaa aacgggtcgc 2364961 ctttttttcg ggctgcttaa tggatacaat gtttttaccg accaataacg ccacattgaa 2365021 gcttttacag ctggcaggct gcgacattgt cattccgcct gaacaggctt gctgcggggc 2365081 gcttcatgga cacagcggtg aaaaaaacac agggaaagag ctcgcgaaac aaaatatcgc 2365141 tgctttcgaa gcattagacg tggatgcagt cattacaaac gcaggaggat gcggagcctt 2365201 tctcactgaa tatgatcatt tgctgaagga tgaccctgag tggtcggaac gggctgccgc 2365261 ttttgttcaa aagctgaagg atttttcttc tgttttggtt gaactcgatt tccatcaaat 2365321 ggatctagca ctcgagacgc ctcaggtcgt tacctaccaa gattcatgtc atctaagaaa 2365381 tgtgatgcat acgtcacttg agccccgcca gcttcttaaa agcatcaaag gggcggaatt 2365441 caaagaaatg gagaaagcag acagctgctg cgggtcagcg ggaatttaca acatcgtcga 2365501 agttgaaatg tctatgaaaa tactggacag caaaatggct gccgtcaaag caaccgaagc 2365561 gatcctcatt gtaacagcaa atcctggctg cctgctgcag atgaagctcg gcattgaacg 2365621 cgaaggacta agcggtaaag tcagagccgt tcacctggct gatttgctat tagaagcagc 2365681 cgggcacaaa acatcatgag aaagcccaaa acagacattg ttttgggctt ttgtgcgtta 2365741 ttccatcgga ctgcaaattt cgatataatg tccatccgga tcagcgatat aggcgaccgt 2365801 ctgcccccat ggtttcactt tcggctcccc gataatcgat acgccttgtt ctctcatcct 2365861 tttgatgacc gcttctacat tttcagtaac aaacccgatt tcaaatgtgt ttgaagcaga 2365921 tgtatccgga atgtccagcg ccgtgatgtc tctggcgctt tcccgggtat taagcgccaa 2365981 tatcgtagac cctgtatcaa attcgacata cgtgccgtgt tcagcacgaa tcggcagtcc 2366041 taaaatatcc cggtaaaaaa tgaatagccc gcttgctgtc cgatacgtat agaataagat 2366101 atttcattga tagattcatt gccaacccct ctcagcattt tcaatagtcc ttctagcccg 2366161 gtatagatgc ttccatcctt aagctcggat ctttccacat ctgcgcccat tttttcacag 2366221 ccgccacgat aatgatgaag cctaacacca gcatgatgat agataatacg ccattcaata 2366281 cactatatcc tgctgcttca ggattgagat acacattgcg caccatccaa tagcccgcat 2366341 aattgacagt gacatataaa taggcaagcg ggataaggca agtcagaatg taccggcgtt 2366401 tatcggcgat tttcagcacg atcgtcgctc cgataatcag ccccactgaa gccatcagct 2366461 gattagaaac gccgaagagc gcccaaatgg aaccgatatc tcctgaatac agcaagtacc 2366521 cccacatcaa acaggcaagc gcgctggcaa atacagagcc cggaatccag tctgttttct 2366581 tcagcggctt atacacctcc ccgaagaagt cctggatcaa ataacgggcg acacgtgtgc 2366641 cggcgtcaat cgctgttaaa ataaagaccg cttcaaacat aatgacaaat tggaaaaagt 2366701 atgaggccaa atggctgaaa aacggcattc cggtaaaaat ataagtcatc cctaccgcaa 2366761 gcgtgacggc tccccctgtt cttccttcta agtccaaacc gatttccccg ctcaattcag 2366821 gcaaatgtac gacattcatg ccaagcgtac ggaaaacctc aggcgtgctg ttaatcgcaa 2366881 agtaatcagc aggctgtaaa gcggtcgctg caatcagcgc catgataccg acaagacact 2366941 caacaagcat tgcgccaaac gcaaccggct tcatatcact ccatttattc agcattttcg 2367001 gtgtcgttcc tgagccgaca aaggcatgga acccagagat cgccccgcag gcgatggtta 2367061 ttgagatgaa cggccagaca ggtcctgcca gcaccggccc tccgcctttt acgaattctg 2367121 taaacgcagg gaacggaatg gacggattga cgacaaacac accaacaatc aaagcgataa 2367181 aaacaccgat tttcataaag ctgcttaaat aatcacgcgg agccagaagc agccaaacgg 2367241 gaagcgcagc cgcaaaaaac gcataaacag gaagcgcgat tgcaagcgtt ttcgtatcta 2367301 gcgttaaaaa gtcaccgagc gcggtagtct gtacccatgg accgataaag actcctgcca 2367361 ttaaaaagag aaagccgacc gttgaagcga gctttaaatt tcccgttttc ttataaaata 2367421 agcccacacc catcgcaatc ggaatcgtaa tccccaccgc aaatgttccc catggattac 2367481 gttcaagcgc atgcaagaca accatcgaca ggcccgccat tgtgatcgtg atgataaaca 2367541 gcatggacag tcctgtacaa aatcctgcaa cagggccaag ctcatccttc gccacttccg 2367601 acagcgattt tccgtttttg cgcatcgatg caaacaacac cacaatatca tggacggctc 2367661 ccccaattac cgccccgatt aacagccaca ataatcccgg caaatagcca aactgcgccg 2367721 ccagaattgg tccgaccagc ggcccggccg ctgcgatcgc ggcaaagtgg tggccgaacg 2367781 aaacccattt atttgtaggc acatagtctt tcccatcctc aagcgcatga gcaggtgttg 2367841 gcttgtcatc attcactttg agaaccttca ccatcataaa tgttccgtat aaacgatagg 2367901 caatagccaa aatacacatt gatgctatca caattgtaac cgcattcatt ttctcccatc 2367961 cccttttctg tttttcataa atatatcata atttcatggt gaaaagcggt cattttttcc 2368021 tatacaaaaa gccggctgga atgggccggc tcgtggcagt tgaaagacaa gccggagaga 2368081 aatctccggc tttgctattc ttatgactgt tttttcaggc ggatcacatt ccaggaaagc 2368141 ggcgtgaaat gagcagttaa gccgttttcg ctgacagacg atgatccgtt ggaatgcgga 2368201 acgacatttt ttctgttatg ctggtttgtt gctttgatat cctgatgctc aagtacgatg 2368261 tgctctgcga tttggtagga ttcaaagcct ctgagcgaaa tctccgtctc catctgatcc 2368321 tcagccttgt ttaccgcaaa aatagtgagt gtttcttcct cttcagagta cacaacagca 2368381 gcatcaacat atggcacatc agtgaaatca gaacaatcgt acttaggaga agaaataagc 2368441 ggtttcagtg actcgcccct tccgtaaaca gaagcatgca tgtatggata gaaaatcggc 2368501 tgtctccatg cttctccgcc tttttccgtc atgatcggcg cgatgacatt aacaagctgt 2368561 gcaagacacg caattttcac acggtctgcg tgctgcagca tcgtaatgag cagagagccg 2368621 actaataagg catcttcaaa attgtaaata tcctctaaaa tcggacgcgc agtgatccac 2368681 ggctcgactt ttttatcagc ctcatttgag tggtaccaga cgttccattc atccagagag 2368741 agattgatag ttttcttgct gcgtgttttt gcttttacat agtcacaggt cgcagcgact 2368801 gatttgataa aatgatccaa atccatagaa cgtgccaagt agtttggcag attgttatcc 2368861 cggtttccgt agtaagtgtg aagagagata tagtcgacat gctcatacgt atgctcaagc 2368921 accttcgctt cccaatcgat aaaggtcggc ataccgctgt ttgagctgcc gcaggcaacg 2368981 agttcaattg atgggtcaac ccacttcatg acctttgctg tctctgcggc aagccgtccg 2369041 tattcatcag ctgttttgtg gccgatctgc catggtccat ccatttcgtt tcctaagcac 2369101 catgttttga tgccatacgg ctgttcatag ccatgcgatc ttcttaaatc actccagtaa 2369161 gagcctttcg gatggttgca atattcaacg agattacggg cggcatctat gcctcttgtg 2369221 ccaaggttga cggccatatt gacctcagtg ttcacctttt ttgcccaaga taaaaattca 2369281 tttgttccca cttcattggt ttctgtcgtt tgccatgcca agtcaagccg tctcgggcgg 2369341 ttttcgactg gtccgacacc gtcctcccag ttgtatccgg ataaaaagtt tccgcccgga 2369401 tagcggatga tgggaacctg taattctttg atcagcgact ggacatcttt tctaaatcca 2369461 tcttcatccg cttcagggtg atcaggctcg tatatgcctt catataccgc acgacccata 2369521 tgttcgataa acgagccata aatccgttta tctacttcac cgattttata ttctttgtct 2369581 acaatcattc gcgctttttt catcacacgt ttcctccttc attaaccttt gactccccct 2369641 accgtcaggc cggagataaa gtacttttgg aaaaacaaga aaatgataat caccggcaaa 2369701 atcgcaaata ctgagccgga tataagcatg tcgtaattat ttccataagg gctcagcaag 2369761 ctggacagcc ctattggaag cgtaaacatt tctttcgacc gaagcacaat cagcggccac 2369821 aagaagttgt tccagctgtt taaggactga aggataatca tcgcaccgaa agccggtttc 2369881 atcagcggtg ccataatcct gaaaaagatg ccgaattccg tacagccgtc catccttgca 2369941 gagtccagca gatctcttgg aaggccaaga gcatattgcc tgaaaaagaa aacagcaaca 2370001 ggtgaaacga taaacggcaa tatgacaccc gtatatgaat cgatcaagtg cagtccgaca 2370061 gtaagtttaa acagaggaag catcatcact tccagcggaa ccatcataat aatcagcaca 2370121 agaacaaaga tgatatttct gcccttaaaa tcataaaccg caagcccgta cccgatcatc 2370181 gaagaaaaaa acagagtgag cacagtcgta aaaagtccga gtacaagact gttaaaaaac 2370241 catttgaaat aaatgctgcc gccattaaac agaaatgtgt agttatcaaa actcatcact 2370301 tttggatcaa tatcaagatt cagccccaca cgcaaaagct cagatgacgg ctttaatgat 2370361 cctaaaagca aacagaaaat cggaaaaaga tacaataggc tcagcatcat aaaaaacagg 2370421 gtcagcgcaa ttctataaac gctaaactga ggactgtgcc gcaacattta tccctccccc 2370481 ttaaacgagc ctgacagctt taatgaaatc aggctgacaa caaggatcac aatcaaaagc 2370541 acaatgccga tggccgctcc gtatcccatt tcattgtagg caagtccctg ctgatacaaa 2370601 tatccgacaa gcgtcagacc aatattaccc ggggaattat tctgccaaag gacgtagctt 2370661 tcctcaaaca tcctgaagcc gccgatgatg ctgatggtca gcacatatac ggttacaggc 2370721 ttgagaaacg gcagcgtgat gtgcagaaat tttttcattg tattcgcgcc gtctatatca 2370781 gcggcttcgt acagctcttt cggcacattt tgcaaacctg ctaaaaagta aaggatgttg 2370841 attcccatcc atctccatga agcaagcagc accatcaaaa acatgccggt atgttcattg 2370901 ttcatccagt tctgaggtga aaagccgagt ttaagtagga tggaattggc cagagacgtt 2370961 tccatttctc cgaagatcag ccgaaaaatg atccccgcga caatggttga ggtcaatgcc 2371021 gggataaata atgctgattt aaatatattt ctaaatttga ccagctttga attcaggaat 2371081 atggccagaa gcaatggaac aggaatcagc acgatcagcg tccaaaaggt gtattccagc 2371141 gtattccaaa gggcggtata gaacgtcggg ttgtttagcg ctgtataatt agacaatccg 2371201 acaaaggaca cctctcccgg caaaattctt tggaagctca tgatgaagac actaatgatg 2371261 gggtatagaa aaaatacgag aaaggataaa acgaatggcg ctgtaaacag atagggcgcc 2371321 gctttttttg aataaaacag atctcgccag cctgattgtt tcgcagctga aggaacggga 2371381 tgaaccgttc ccgttttcac aggtttcatg agaacctccc cgctttcact ttttgaatgg 2371441 gattctattt ctgtttcagt tcacctgccg ctctgtccaa ggcttgttta ggcgtttttt 2371501 gctgagattt aagcgcgtcg aacaatacgc ttctgttgac aaggtctgaa gccttggcaa 2371561 aatcctcatg taaataaatt ggattgattt catccttgat atcgagcagc acagaaaaaa 2371621 tgcctgttcc gttttggaag taatccgtgt atttgttttt ctctttcaat tccttggagc 2371681 tccaaacatc ccagcgaagc gggtcaaagc cgagtacgct ccagagtttt ttatttcctt 2371741 cttcagagcc cttcgcaaag gccaaaaact cttttgctaa ctcaacatgc ttggattgct 2371801 tcggtacaac agttgccgta ccgcccaaac ctgccgagcg gtcgcccccc tctttccatg 2371861 ccgggagcgg tctgatggca atcttccctt tcagatcagg catataatcg ataaatcttc 2371921 ccatatacca aatcggcatg agaactgaag cagctcctcc ttggttcata aagccgtagt 2371981 attcttcact gtgatgcccg ccgcccggcg caggaatcat cgttttatca ttgatcatgt 2372041 cttttaaata ttgaagtgtt tttacgttgg tgtcattatt gaggatcagc ttgccgtttt 2372101 tatcaaaata gcctgagttt tgctgtgaaa tcatagataa gaacgttgcg gaatcatttg 2372161 tttccaccgt tcccatcggc ttcccggtca ctttgcgcac tttctgtccg gctttatggt 2372221 aatcatccca tgttttaata tcgtcaggat tgacgccggc ttttttcatc acatccatgt 2372281 tataaaacat gaccgttgtc cctacatgtg tatcgagtcc gtaaagcttt ccgtttttgc 2372341 tgtacaatgt cagccgcgcc tcaacgaatt tatcgcgatc cttttcaatc agcggagtca 2372401 agtcggcaag cggtatgtca gagcccttca aaaagtttga aaaacgggcc aattcgacat 2372461 ctgcaatatc aggaacgcct tctcccgcta ttagggagat agataagtta tcgtgcattt 2372521 gtccatatgg ataaacgacc gtattcagct taattttgcg gtcaggatat tttttgttcc 2372581 attccttcac catttccaca tagaactgct catgaagccc gttaaatgtc caaaaggtca 2372641 gctcagtttc acccgatttg ccggatgatt tttctgctga acacccggca atgactaatg 2372701 tcagcaacat catgagcaca agaaaacaga cagtcatttt tttcatctgc gttacccctt 2372761 ccattcgagg tgcgggctat tcatatagac catggttgat cagcgttttg ttttcattga 2372821 tgattcttaa tccggtgcat cggtctctta aggtgtgcgc gtgtctgaag gcatttttga 2372881 cggaatcctg cccgacaccg atttcgtcaa aatacgcagg gcctccggct gatctcagcc 2372941 aatcagccag cacttctcct ctcgggagtg tttgataagc cgattggatg gcttcccggc 2373001 ggcttggtga aaattcgttc agcccgtcat cctgagcgag ctttctgtat gtgtcagtta 2373061 ataaaacagc ggcacagccc acctttgccc catgaagaat ctgaggccgt tttttctcca 2373121 ttaactccat ttcaatccaa tgtgaaatat gatgctcgcc gcctgatgcc ggtcgggaat 2373181 gatctaatgc cagcatgaca agccccgata caagtaaaga ctccatcaaa acccgtatgc 2373241 cagtttccgt tttcatcgca atgtcttctg tgtgttcaat gcaggcagca agcgcctcct 2373301 gaacgatctt agctcctgca ggcgaataag gctcaccggc aagatgccgg gatatttccc 2373361 aatctgctaa agacgtgatt ttaccgagca tgtcaccaaa gccagccgcc accattgact 2373421 gcggtgccgc ttttaataga tccagatcag cgaacagcgc agatggggcc ttcgtttgaa 2373481 tggttgtttt cgtgccgtat aaaataatcg gcgcaccggc tgatgtaaaa ccgtctacag 2373541 atggagcagt cggataagaa ataaacggca aatctctttg aaacgccgca aagcggacga 2373601 tatcatgaat cgtgcccgaa ccgactgcga tcatgacatc cgttggttgt ttcgtatgga 2373661 tcagcacatg aatgagcgat cgttcatcag ctgtcacatc tccggcttca ttttctggaa 2373721 tgatcaggca ctcggcctga aatccttctt gattcagtcg gttttctaaa tcaattcctg 2373781 caatgcggtg tgtattcgcg tcgcagacaa ggacaatatg ttgattgttt tttcgtttta 2373841 cataatccaa aagcgaatca gctgcttgct taccgagaac aatttcttca acttttatag 2373901 gcaacgtctt ttctccggcg ttttcaaaag cacgctgaac gtcagctgcg atacgattca 2373961 tatcagaatc ccctcctcag ccaatttggt tacatcctta atagaatcca gcacataatc 2374021 cggcgtgtac aaacgctgtt caccctgttt cgcagaacca gttagcacta aggcgctttt 2374081 catgccataa agcttcccca tcgcaatgtc agattcaatg ctgtctccta taatcatgca 2374141 ttcatgtgcg gacagcccca ttgctgtaca ggcagcctcc gccatcagcc atgacggttt 2374201 tccgacaaca agttcagtct tcgcttgtgc agaagtctca attgccccga tcattccggc 2374261 cacatcaatg gcatttccgt cttcgttcgg aaaagagcgg tctttgtttg tagcgataat 2374321 acgagcgccg ccggcagccg cttgaaaggc ttgatttaaa tcgtcgtacg tgagcgtttc 2374381 atgaagggag atcacgagcc aatccgcttc cttcggttcg ctcgcgttct gcacaccggc 2374441 cagcctcagc tcgtcaacca agccttgctc cccaagcacc catacctttg aaaaacgata 2374501 atgttttttc agaaaagccg ctgtcacgct tgatgacaga acaatgtcgt ttacgtccgt 2374561 ttcaatcccc gcgccaagaa gtttttttct gcacatggca cgggagatat tcccccggtt 2374621 gcttaaaaag acgattttct ttcccattct cctaagcgtt ttgatcgctt ctcttgctcc 2374681 ttcgatcaac tcatttcctc tgaatacagt accgtccaag tcaatcagaa tgccagccgg 2374741 tgacacaggc gtatcatgac tggccataat acgcatttgc tccgtgtttt cgataaaaat 2374801 gcttttcatg caggactgta ttgattgggg ttacatcctt gttcagcata atggagtgat 2374861 aggccatttc ggcaaccgtt tctaatacaa ctgcgttatg aatggcattt aaggcgtcag 2374921 tgccccagca gaacggtccg tgattattca cgagcacacc cggcacctgt tcgtaattat 2374981 gatgctgaaa ggtttccgct atgacttttc ctgtattcag ttcgtagtca tgaatgattt 2375041 cttcatcgta catttctcga gtacatggaa tcgcactgtc aaaataatca gcatgggtcg 2375101 tgcctaacgg agggatgtct ctgcccgatt gcgcccagct tgtcgcccat tgagaatggg 2375161 tatggacaat tcccccgata ttcggaaagg ctttatatag ataaacatgg gtaggtgtat 2375221 ctgaagaagg tttaagcgag ccttcgacga cctctccatc aaggttcaaa acaaccaagt 2375281 catcggctgt caggtcgctg tattcgactc cgctaggttt gatgacaatt ctttcttttt 2375341 cacggtcaat gccgctgaca tttccccacg taaaggttac cagctgatgc tcttgaagct 2375401 tcaggttggc agccagcact tcttttttta atgtttcaag catgctccat caccctttat 2375461 caattctttt tggcggcaga tgaaaattga agatttttga tcgttttcag acgcttcatg 2375521 acatggtttt cttttccgaa ataatgaacc agctctttat attcagcgta caatttttca 2375581 taaaccgcgg cgttttcggc atttggcgta taagttatat ctttcagttt tcccatgttc 2375641 gccgctgcct ttttgatatc atcgtagccg cctttttctt tgcctgctgc aagcgcgccg 2375701 aaaatggcag atcctaaggc tggggcttgc ggtgaaccag agattttaat gtccatgttt 2375761 gtcacatccg cataaatctg catgacaaac gggtttttct cagctattcc gccggctgcg 2375821 aacagttcct caatcggaac accgctttct ttgaatgttt cgataatcat ccgggttccg 2375881 taagctgtcg cttcaactaa cgctctataa atctcttcag gcttcgtcag cagtgtcatg 2375941 ccaagcagca tccctgttaa atctgcatca acaagagttg aacggtttcc attccaccaa 2376001 tctaaagcaa gcaagccgct ttcaccaggc gcttgatggt ttgctttctc actcagcagc 2376061 tcatgaacgc caatgttttt ttcctttgct tcctcttgat aagctggcgg gacacatgtt 2376121 ttcacaaacc agtcaaaatg atcgccgaca caggactgcc cggcttcata tcccgcatag 2376181 cccgggagaa ttccgttgtc cacaacgccg cacattcctg gaacgatatg cacctcttca 2376241 ccaagtagaa catggcacgt cgaggttccc ataatcatca gcattttccc tggctctgta 2376301 atgccgaccg ccggtaccga aacatgagcg tccacattgg caaccgcaac agccgttccc 2376361 gggagaagcc ctgtcagctt tgccattttt tcagtcagac tgccggcttt ttctcctact 2376421 gaatgaatag aacctgacaa tttgtccttt gtaatcgttt tcattgaagg atttaatttc 2376481 tcaaagaaat catctgacgg ataccccgct ttttcactcc acatcgcttt ataccctgcg 2376541 gtacaattgc ttcgcttgag cgagccgcac agctggtaca cgatccagtc cgcagcctcg 2376601 atgatccggt cagccgcttc ataaatgtga ggcgcttcct cggcaatttg catgaccttt 2376661 ggaatcatcc attctgatga aatttttcct ccgtaccgct gtaaaaaagc ctctccttct 2376721 tcttccgcga tttgattgag ccgatcagca tgtttttggg ccgcatgatg cttccagagc 2376781 ttcacatagc tgtgcggctc ctcttcatat tcaggcagca tgcataacgg ctgcccgctg 2376841 ctgtcaatag gaaggatcgt acatgccgtg aaatcaattc caatcccgat aatgtctttc 2376901 gggtcaacgc ccgtctgttc gagtaaagac ggaatggttg tttccaagac ttcgaggtaa 2376961 tcagcagggt gctgcagcgc ccagtcacgc ggcagctttt gacccgtttt tggaaggacg 2377021 gtatcaatga cagcatgcct gtattctttt acagcagccg caagttcctc ccctgtttgg 2377081 acatgaacga gcactgctct tcctgataaa gttccaaaat caacccctat tgtgtaagcc 2377141 atgtgacatc cccctctact tttgaagccg gtaaagcgcc tcgttccatt ttaactcgtg 2377201 tttcagttta tgaattgtcg tatcacggga aatgagaaca ctttcgattc ccgccatttc 2377261 cgcccaatca agcatttgct ccgctgtcag ttcataagac aggcaggtat ggtgtgcacc 2377321 gccggctaaa atccatgcct ccgctgctgt tttcaatgac ggctccggct tccagagaac 2377381 acgggcaacc ggtaaattcg gcatgtcttt ttcaatttcc tggccgttga cttcattcag 2377441 cacaaggcgg aaacgcccgc caatatcaac aatgctagct tgaatggcag aaccgctgat 2377501 gccgttaaat accaaacgcg cagggtcctc tttgccgcca atcgaaagcg aatgaacctc 2377561 gattttcggc tgatccaaag cgacagtcgg acacacttca agcatgtgag agcccagaat 2377621 catttcattt cccggttcaa aatggtacgt gtaatcttcc atgaaggaag ttctttttcc 2377681 tttagccatg attttcatca tccgtacaag ggccgctgtc ttccaatctc cttcaccggc 2377741 aaacccatag cctttctcca tcaggcgctg aacggcaagt cccggcagct gtttcattcc 2377801 gtgcagcact tcaaacgatg tcgtaaacgc tgtgtatccg ccttgctcaa gaaaagcggt 2377861 taatccaagt tcaattttcg cctgttcttt aatggacgct acctttgctt cgtcacgttt 2377921 tgtttcctca ctgatcacat atagtctgtc atactcggca taaagcgtgt caacctcgtc 2377981 gtccgtaatg cgatccatca cttcaacgag atccccgatg ccatatccgt caacctgcca 2378041 gccaaattga atatgcgctc ccaccttgtc tccgtccgtt accgcgacat gacgcatgtt 2378101 atctccaaat ctggcaacct taatatgtct gctttcattt aatgcagccg ccgtatccat 2378161 ccactgggac atttcttttt tcacttcttc atcatcccaa tagccggcaa tgacttttcg 2378221 gctaagcccc attctcgagt tgatgtaacc gtactctcga tcgccatgcg cggattggtt 2378281 gctgttcata aaatccatgt caatcgtacc ccacgggata tcgcgattat attgggtatg 2378341 caaatgcata agcggttttt gataagagga aaggccttct atccacattt ttgcagggga 2378401 aaatgtgtgc atccatgtaa tgatgccagc acatgtctca ctgtactccg cttctcttaa 2378461 cagctctcta atggtttccg gtgaagtgac gacgggctta tgagtgattt tatatctgga 2378521 agaaatcccg ctgagcccct cacaaatgct tttagcatgc tgatctacga gttccagcgt 2378581 ctcttccccg tataggtgct ggcttcctgt cacaaaccag aattcataat cctttgtctg 2378641 aagcatgtaa actgcccctt tctcataaaa taaaacgctt tcaaatacaa aagatacgta 2378701 ctaatgatag aaaataaacc tataaataaa tatttgtacg aacaatttta ttatagtaat 2378761 tgactattat actgtcaatc ttttctttta aaaaaagccg ggggcagagc ccggcttttt 2378821 aattcaatag gacggccagc ccgagctcca attcaaatca ttgatgagaa gctttggaat 2378881 gccgttgtca ttggcatcat aggcatggcg aacaagaatg tttccgttca caatatcctg 2378941 gcctccaggt cctttccatt ggtcattgcc cgaatccaaa atggtgcctc cgccttcaag 2379001 catgcttttt ccgcttttat caagataagg gcctgtaatg cttttggatc ttccgtaagc 2379061 aattttgtac gtactgttta ccccgtcaca gcatttatca aatgaaacca ttaaatagta 2379121 atatccattt tgatacgtaa gagtaggagc ttctaaggca cctccattat tcggtctagc 2379181 tgcaatcgaa tagagcgagc ctgtaggctt cattgtactc ttatcgagct tagtcagctt 2379241 aatgccgctc caaaacgagc cgaatgcaag ccacgggttg ccatccttat cgaatgtcag 2379301 ctccggatca atggcgttat aattatttga gcttgtcgaa cggatcacca agccctcgtc 2379361 cttccagccc cccgaactga tgcttgttga agatgccagg ccaatggcag atgtattgct 2379421 tccaaaagaa gaaacggaat aatatagcca gtacttgccg ttatagtatt ggatgtccgg 2379481 cgcccactgg ttttggccat aattcggcac ataattggac caccacgata gcggtgtagt 2379541 gaaaatggat ttttgtacgg tccaattttt agcgtctgaa gacttcaaaa cccgcagtcc 2379601 ccgttcttca gtaagccctg ttccgagcgc ataccatgag ctcccctctt taatcatagt 2379661 cgggtcatga agcagctcat tggatgcacc ccaaaacgct gcctctgcgg gagcagcaga 2379721 agtgaatatc aaacctgcag ccagagctgc actcgaaaag tgtaagaagc gtttccatgt 2379781 ttttttcttt ttcaattttg ttcaacctcc tttattttag aaagcgctta caaattagat 2379841 tatttatcct cccttcctgt caaatcgact gcgtatcgta tatcgtcatg ttcaggaaat 2379901 tttcggtatc ccctttattg tagtcactat gctgtaattt gtacagacaa aaaaatagaa 2379961 tccacctcaa taggcggatt cttccgtatc tttattggta cgtaatttcg tcaaccgttt 2380021 ttcggtctaa cttcttaatg acttctgtaa ttaactttac cgcgttttca taatcatcac 2380081 gatgcagcat ggccgcgtgc gtatgaatgt agcgggttgc aatggtaatg gacagcgcag 2380141 gaacgccatt tgccgtcaaa tggatggcac ccgaatcagt tccgccgccg gcaatggcat 2380201 caaattggta cggaatgccg gcttcctccg cagtggctac aactgcatcg cgcaaacctt 2380261 tgtgagagac catggatgca tcgtaaacga taatctgcgg gcctttgccc attttgctct 2380321 gcgcttcctt ctcggaaatg ccaggcgtgt ctcctgctat ccctacatca acaccaaacg 2380381 caatatcagg ctgaatggtg tgtgcagccg ttttcgctcc cctcagcccg acttcctcct 2380441 gcacggttcc gacgccatac actatatttg gatgatctgt gttttgtaag tttcttaaca 2380501 catcaatagc aatcgcacag ccgatgcggt tgtcccaggc ctttgcgagt aggaattttt 2380561 cattgttcat gaccgtaaat tcaaaatgcg gaacgatcat atctcccgga agtacacccc 2380621 actccaaggc ttcttcccgg cttgaagctc caatatcaat aaacatgtct tttatttcca 2380681 ctgatttttt tcttgcttca ggagacaaaa tatgaggcgg cttagatccg ataacccctg 2380741 tgatttctcc tttttttgtg acaatggtga cgcgctgagc aagcataacc tgagcccacc 2380801 agccgccaac ggtttgaaaa cggataaagc ctttatctgt gatttgtgtc accataaagc 2380861 cgacttcatc caaatgtccg gcgatcataa ttttcgggcc gttttctgca ccagtttttt 2380921 ttgcaattaa actgcccagg cgatctgttg tcacctcatc agcaaatggt tctatgtatg 2380981 atttcatcac ttgccttact tctctttcat tgcccggtat gccttttgca tctgttaaat 2381041 ctttcagcat ggtcaatgtt tcatctaatt ttgccatgtt ccaaaccctc cttcatcagt 2381101 cctgcattct tattatacaa aacatggcgc taaccatacg actatttcac ttgaaaatcg 2381161 ggtatatgtt tttacagctt tcttttagaa aaagtgaaac ctttttctat gcttttcgta 2381221 ttacatcaga tcatcaccat aagggaggtg ccttcacaca atgtttgtca tggttctaag 2381281 gattattttg cttgcacttt ttgcttattg tatttatgcc gtggtcaaat atgtcgcgaa 2381341 tcctaagaga aggcttaagc tggcccaatc aaaagaacat ttttatatta ttgatgaaca 2381401 aaacaatacc cggaagaatt ttcagctgac gtataaaggc gtgctttttg agggagaaaa 2381461 gcatattcct tccaaggatc atccgctgtt tattcacacg atctttgtct ggacagaatc 2381521 tcctgagaag ctgaaacatt tctctgcaaa agattttgag aacattgaag aaaaagtgct 2381581 ggaacgatat ccaaattgta agattgactg ggaccagccc attaaactcg caaaaaaagc 2381641 agaagagcgt taaacgcttt tctgcttttt ataaatcaaa cgggctgtag taaatagcga 2381701 tgagaatcgc ttctattacc agaagaagcg gtactccgta cttaaaagaa gcgtgtttcg 2381761 ttttatgtct gaaggtttgc atgccaagcc agacaccgag cgctccaaac acgatggcta 2381821 tcagccacag ccggtcttca gaaattctcc acttgtgctg ctgcgctttg cgtttgtcaa 2381881 tgcccatcac ccaaaaaccg cacagattaa tcaacaccaa ataagcagca ataatcatgt 2381941 tgcctcatcc tttatataga aaaagccgct ctgctggaga gcggctctat atgattactt 2382001 gtttaattga gctttagcag catcagcaag ctgattgaat gcagtaagat cgtttacagc 2382061 aagatcagca agcattttac ggtttacttc gataccagaa agcttaagac cgtgcattaa 2382121 acggctgtaa gaaaggccgt tcatgcgagc agctgcgttg atacgagtga tccaaagttt 2382181 acggaaatca cgttttttct gacgacggtc acggaaagca tagtttccag atttcatgac 2382241 ctgctggtta gctactttgt ataatgtatg ttttgaaccg aaataacctt ttgctaattt 2382301 aagaaccttt ttacgacgct tacgtgtaac agttccgcct tttactcttg gcattgaatt 2382361 tccctcctaa ttgttcctta tccgattact tgatgttagc aagcatttgt ttgatacgtt 2382421 tgaagtctcc tgcgcttaca acagcactct tgcgaagctt acgcttttgc ttttgagatt 2382481 tgttggcgaa taagtgactt gtgtacgcgt gagaacgttt taacttccca gaacctgtct 2382541 ttttaaaacg tttagcagat ccgcggtgag ttttcatttt tggcatggga tttcctcctt 2382601 attgcttttc gtttttcggt gcgagcatta agaacatgct gcggccgtcc atttttggtt 2382661 ttgtttcgac tgtcgcaacc tcagcacatg cttcggagaa acggtctaat acacgctgac 2382721 cgatttcttt atgagtgatt gcgcgtcctt taaagcggat agaagctttc actttatcgc 2382781 ctttttcaag gaatttaatc gcattgcgca atttcgtgtt aaagtcatgc tcatcgattg 2382841 tcggacttaa ccgaacttct tttaagttaa tgattttttg attcttgcgt gcttcttttt 2382901 cctttttctg ctgctcaaat cggaacttac cgtagtccat gattcggcag acaggcggtt 2382961 ttgcattcgc tgcaactaac acaaggtcaa gatttgcgcg gccggcgatt tcaagtgctt 2383021 cctgacggga cttgattcca agctggtcgc cattttgtcc gattaaacgg acctcacgtg 2383081 cacggatacc ctcattaacc aattgatctt tgctaataat gagccacctc catagtttct 2383141 tcgaattgat tcacaactca ttttgaatgc attttgcagg caaacaaaaa gtgtgggcat 2383201 tataaaacac ccacactacg aacatctgta tcaataaaaa tgtacggtca acctgccaac 2383261 tacatgcatg tgtcaatcag gtgagaagcg ggtgcttctg cttgtgattt atattcaatt 2383321 caataactat tctacacaat accggatctt tagtcaagga cgacttatcc ggaacaactt 2383381 ttacattgta acatgggttt tctatgagcg caagagagaa aaagaaaatc tttcatcccc 2383441 acccagaata caaagaacca acaattcccc cttattacgc aatttacaac aaaaccaccg 2383501 acaggaagaa atgtaaaaca aagttaatct ctgaccgata taaggagcag aagggagcct 2383561 gacacatgaa caaactgata cagcttgctt tatttttcac attgatgtta accggttgct 2383621 cgaatagcag cacatcttcc gaatcaaaag tcgaaaccac tgttaagaca acggcagcat 2383681 ttcctcaaaa ggagctggag aaagagctaa aaaaactaaa acccgtttca ttggacatga 2383741 agttcgagag tccactcgct accgagttag gaaagcggaa ggcaaaagag gaagctgaaa 2383801 agcaaagaca aatcgccgct gagaaaaagc ttgaaaaaga gcgggaggcg aaacgaaaga 2383861 aacagcagga ggaaaaagcg gagagacagc gattagcaga gcagcaggct gcagagagac 2383921 agcgattagc cgaagcggaa agacaagctg aacttgaaag acagcggcag gcagcaatcc 2383981 aaaaagagca gaaagcgaac gctgagaaaa agcggcaatc gcaggcacaa cggcagcaga 2384041 ctgaggcacc ctcatctaat agtcaagatc caccatcttc ctcgagtcag acagataaaa 2384101 ccattcaaca gccagcttca gagcttcctg atgacgatgg ttatggttat gaagaacgaa 2384161 aaaagtggca tgacgatcaa gtagaatggg gcattaaaca agggtatatc gatcccgaag 2384221 acgcaccata aaataaaaaa agccaaggca ttcagccttg gcttatcctc cgatcagctg 2384281 cacgaacaca gggatgacca gaaccgttac cactcctact acgacaacag caatacttgc 2384341 catcgcagct tcaacttctc ccatctcaat cccgaccgct acaccaagtg catgtccgga 2384401 tgttccaaga gccaatcctt tagaaatcgg atttttcact ttaaacacct tcaagaacaa 2384461 tgctccgagc gcatatacga tgacagcgtt aaagatgacc gcaaaggctg tgatgtcgct 2384521 gatgcccccg atgccttttg ataaaggaag cgcaattgcc gttgtagccg cctgcggaag 2384581 catgcttttc attacggccg aatcgagatg aatgccttta gcgagcagat aaacaatcgt 2384641 gacagagcag atagagccgg caataatgga ggccatgatt tgccaccagt actttttaag 2384701 cttatctctt tgtttgtaca aaggaattgc aaatgcgatc gttgccggtt caagaaaaaa 2384761 cttaatgatc tctcccccgt tattataatc cgcgtaggaa aaaccgccga tttttaaaaa 2384821 tgcgatcccc agcaccatgg caacaaacaa aggagtgaaa aggaagaagc ctttcgtttt 2384881 cttaaataaa aaggtgccga tgccgaatgc agcaagtgat acgacaatcc caaaataagg 2384941 actcattgtg ctttccatgt gaagaacctc ctgtttccct taatggtgaa cgagttcgtt 2385001 attgttctgc gggctttgca ctgtttttgt tttcatgtcc gcttcggttt tgcgttttcc 2385061 gctcagcgac agaatcagct gagaaaacaa tcccgtagcc cccagcaaaa taatcgttgc 2385121 gagcagaatg acaagaacaa tttgcaggcc gtattgctgc atcacaccaa gcgaattcat 2385181 aacagatata cctgatggaa caaataaaaa tccgatcaga gaggttaaag acgttccgag 2385241 cgtctccact tgttccagtt taatgacttt caaacataat aggagaaata ataagaccaa 2385301 ccctacaacc gatgccggga taggtattgg gacaatagcg gcaatcatat ttgaaaccag 2385361 cataatgacg gcaaaaataa atgcttgtgt taaaaacccg tacacttttt tagcactcat 2385421 tttcttcacc tctttctctt tggtaccctc attataaata agaattccct gttataaagc 2385481 gcttacaaga taacatgccg tatagcgggt ctgagttgca gaatcaaatg gctgaaatgc 2385541 aaaaagccgc ccatcaaata tggagcagct ttttcaattc cttcgcatat gtccggctga 2385601 ccggtatttt cgatccgtct ttcatgatca gattatacgt tgaattaaac catggctgaa 2385661 tttctttaat atattcagta ttcacgacaa agctccgatg gacgcggata aaatcagaat 2385721 ccggcagctt tttctcaatc acaacgagtg tatcgctgac cgtataagaa tgatcgaagg 2385781 tttttacatt gacatgacca tcttctgttc cggcatagat aatgtccttc gtatccacaa 2385841 tcacaatcga ttcccccaca gatagcgcga gcttgtgctg gccggcatgg ctgttttgct 2385901 ctgtttctac aatatcccga ttgacttttt tatatttttt cagcgtttgc tgaattcttt 2385961 cttcatcgaa aggcttggtt aaataatcaa gagcgtccac ctcaaacgct ttgagcgcat 2386021 actggtcata cgctgtcgca aacacaatag caggaggatg cttcattttc ttcaatcgct 2386081 ttgcgatatc aaaaccgttt tctccggata aatcaacgtc taaaaacagc aaatcaggtt 2386141 tttgatccat catttggtca aaagcggatt cgatattttc cgcttcattg atttccattt 2386201 catcattggt ccgcttaagc aagtaagcca gttcatccct tgccagcatc tcatcatcaa 2386261 ctattaacac cctgagcatg ttcttctccc tctttcatct gttgcattgg cacttgaaag 2386321 gaaacctctg tccctttatg aacctcactg ctgatatgca gtgcagcctg ctgtccgaat 2386381 aaaccgatca gccgctgatt taggttataa agcgctgtac cggttccctc cttagacgga 2386441 aacggtttct tccccagttc cggcaagacg tccggcggaa ttccgcgtcc gttatccgcc 2386501 accttcatat agacggatgc atcatcagat aagacacaga ctgtaacctt gcatatgtct 2386561 tgttttttcg gaaacgcgtg ccgaagcgcg ttctcgacaa gcacctgcaa aacaaacgga 2386621 gggatttcaa tctgctccag tctgctgtcg atattaagct caattttata tttcccggga 2386681 aaacgcgcct gttctaatga caaataggcg ttaagatggt tcagctcctt tgagagcgga 2386741 atcagcagct gtctcgctcc ttgaaggttt gaacgaaaat aaacactgag ctgcaatagg 2386801 agcttacggg ttttttcaac atctgtacgg cataacgcag aaatcgtgtt gatcgcatta 2386861 aataaaaaat gcggattcac ctgtgcttga agcgctttaa tttcagcatc cttgagaagt 2386921 ttgctttgca gctctgcttc cccaagctca agctgtgtcg aaaacagcat ggccagcccc 2386981 tcggcaagtt cctcctctac ctgactcagg cctgccgggc ttttaaagta catttttaag 2387041 gtgccgattg tattgccgtt cgatgtcagc ggtaggacaa ttgcagcgtg caaagggcat 2387101 tcagcatgcg tgcattcaat ctcttcctgc gaaatcgcct tcataatatg ccctgtttta 2387161 atcacctttt tggacaggcc ggtgatcaag cttttcgatg ggatgtggtg atccattccc 2387221 gcaccgacat gcgcaaggat cttttctttg tcagtgagag acaccgcatc tgttcctgtc 2387281 agcttatgga taatagccgc tacactttta caggagtttt catttaatcc ttggcggaaa 2387341 aatggaagtg tctgatcagc aatcgtaagc actcgatgcg tttcgagagc ccttgcctgt 2387401 tcttccttgc gaatgatcgc ttgaataata gacagaaaaa taaaactgcc tgttccattg 2387461 atgagtatca tcggaattcc gatcatgctg acaagctccc aagcgtcact gaacggcttt 2387521 gccatcagca aaataatgat catttgcagt gactccatgc cgattcccac aagagcggcg 2387581 atgcgcggtg tcggcattcg atatcgcttc gtaaaatacc tgccgatcaa gcctgcaaga 2387641 acacccgcta aaatagatga gacggcacag cttaaggccg tgctgccacc gagtgaaaaa 2387701 cgatgcaggc ccgcaagtat gccgatccca gcccctacaa aaggacctcc gagaaggccc 2387761 ccgatttcca cgcccaaaat acgggtattc gcgatagagc ccgatggatc tatcgtaaac 2387821 acccagtcat tgtttacaat catatttctt tgaatttcga tgcctgtata attgctgatg 2387881 atgctgaaaa gagaaaaaat agaaattaaa atcgcttttc ctttatagcc gtcctgattc 2387941 tgaagagctt gtctgaaaag tttcgtatgg gcgagaatga accctaatat aacaataatc 2388001 cccactctct ccagcatcat aatcattaaa tgaatcattc atgtcacctg ttctttccgt 2388061 tttcattcta gcatgttttc gttttgcggc tgactgtttt tttaaaatcg tctgaaaaca 2388121 tatttcacaa ggcttttatc tattgtaaaa taaaacatga gccttttggc agaaagattt 2388181 gaatctgaag cagaggagaa gatcatgaaa gccgtatttt ttgatttaga tgatacacta 2388241 ctttgggacg aaaaaagcgt cagaacaaca tttgcagaaa cttgcttaca ggcggagaaa 2388301 aaatatggcc ttgcccctga ggaattcgaa gcagctgttc gcgaagcggc gagagaattg 2388361 tacatgtcat atgagacgta tccatataca gtgatgatcg gcattaaccc gtttgaagga 2388421 ctgtggtcca atttctcaga gccaatcagt gaaggctttc aaaagctgaa caagattgtg 2388481 ccggagtaca gaagaaatgc atggaccaac ggactgaaag cgcttgggat cgatgatcct 2388541 gcatatggcg aatacttggg agagtttttt gcggcagagc gcagaaagcg cccgtttgta 2388601 tatgatgaaa cttttgctgt actcgatcaa ttaaaaggca agtatgaatt attgcttttg 2388661 acaaatggcg atcctagtct gcaaaaggag aagcttgccg gcgtgcctga gctcgctcct 2388721 tacttcaatg aaatcgtcat ctcgggcgca ttcggcaagg gcaagccgga tgtttcaatt 2388781 tttgaacact gccttaagct gatgaatatt gaaaaagacg atgccatcat ggtcggcgat 2388841 aatttgaata ctgatatttt aggcgcttca agagccggaa tcaaaaccgt ttggatcaac 2388901 cggactgata agaaaaacga aactgacgta aagcctgatt acatcatcag cagccttcat 2388961 gatttgtttc ctatattaga gaaataaaaa aagcatgatc tcttcaatga gatcatgctt 2389021 ttttatttta ttttttcgct tcagctactg cctttttcac aaactcatca agtgaaatgg 2389081 tttcagagtt ctgttctccg tatttacgca cgtttaccgc tccgttttct gcttcttggt 2389141 caccgaccac cagcatgtac gggatttttt gcatttgcgc ttcacggatt ttgtagccga 2389201 ttttttcatc gcggctgtcg acttcaacac gcaggccttc acattgcagg cgttcctgca 2389261 cttttttcgc gtagtctaaa tgcacagccg gagaaaccgg gatgacttgg aactgaaccg 2389321 gtgcaagcca tgtcggcagc gcgcctttgt gttcttcgat taagaaagca acaaagcgtt 2389381 ccattgttga aacgacacct ctgtgaatga caaccggacg gtgctgcttg ccgtcctcac 2389441 cgatgtatgt caggtcgaaa cgttccggca ataagaaatc aagctgaacc gtagacagtg 2389501 tttcttcttt tccgatcgca gttttcacct gaacatcaag tttaggtccg tagaatgccg 2389561 cttcaccttc tgcttcgtaa tagtcgtggc cgatttcatc cattgcctct ttcagcatgg 2389621 attgcgcttt gttccacatt tcatcgtcat caaaatattt ctctgtatct tccggatcgc 2389681 ggtaagacag acggaatgtg taatcactta aaccgaagtc ttcataaaca tcctggatta 2389741 aacggactgt acggataaac tcatccttaa tttgatccgg gcgcacaaag atgtgtgcat 2389801 catttaacgt cattccgcgt acccgttgaa gtcctgacag cgcacctgac atttcatagc 2389861 ggtgcatcgt tccaagctct gcaatacgaa tcggaagctc gcggtaactg tgaatgtctt 2389921 gtttgtaaat catcatatgg tgcggacagt tcatcggacg caatacaagt gtttcattgt 2389981 ccatttccat cggagggaac atgccttcct gataatgatc ccagtgtcct gatgtttcat 2390041 acagctcttt gctgcctagc acaggtgtgt atacgtgctc atagccgagg ctgatttctt 2390101 tatcgacaat gtagcgctcg atgacgcggc ggattgttgc gccttttggc agccaaagcg 2390161 gcaggccttg tccgactttt tgagagttcg cgaacagctt taattctttg ccaagctttc 2390221 tgtggtcgcg ttctttcgct tcttctagca tacgaagatg ctcttcaaga tcagcttttt 2390281 tgaagaaagc tgtaccatat acgcgctgaa gcatttggtt tttgctgtca ccgcgccagt 2390341 atgcgcctgc aaggcttaac agcttaaatt ctttgatttt tccggttgaa ggaacatgga 2390401 cgccgcggca caggtcaaag aattcgcctt gctcatagat cgaaacggtt tctccttcag 2390461 gaatcgcatc caatagttca agcttcaggt cgtcgccgat ttccgcaaaa cgggctttcg 2390521 cttcttcacg gctgacttct tttcgaacga tcggaaggtt cgcattaacg atttttttca 2390581 tttctttctc gattttcggc agatcctccg gtgtaatcgc ttcgtccatt tctacatcgt 2390641 agtaaaaacc gttttcgata accggaccga cgccgaattt aacatccttg tagatgcgtt 2390701 taatcgcttg agccagcaag tgagccgcac tgtggcgcat aatttgaaga ccttcttctg 2390761 agccttctgt aatgatttcc actgtaccgt cttcattgat cggcgttctc aaatcgattt 2390821 cttttccgtt cagttttccg gctaatgact ttttctttaa tcccggactg atggatgccg 2390881 cgatatcttc tgttgttgtt cctttcgcaa actccttgac tgctccatca ggaaatgtga 2390941 tttttaccat atctgacatc tttgtcactc ctttttttgc atataaaaac cccgccccct 2391001 atgaaaggga cgaggttgaa taaacggaat cgtggttcca cccttttttc cgcaaagcca 2391061 atacacggca cctgcggctc taagctctgt aacgggagtt cccgtcagcc attactgttc 2391121 cttttcaaga ggttcacagc tgaagttcaa aggcggtaaa gcgaatggtc cttagctggg 2391181 aagcttgcag ccagggcttc cctctctttg agccggtatc attccttcgt gtccttatca 2391241 atacgtgtgt ctttcttaat ctcctatgta ttataaattg ttcaatccaa aaaatcaaca 2391301 cgatcgcgtt tccttttttt taaaccgaca gccttaaata gacaggctgc cggccctcat 2391361 ccttccgagt gcttcaccgg tatttctgca tctgtaaaag catgcagcgg gagcatttcc 2391421 actctctctt gaaatacgtt ttgaatggtc cttgccatca tgtgctcggg ctggtcggta 2391481 taaagcacga cttcatcagg cgcaatggaa atcagcggcg cgagcaaatg agaatcaata 2391541 tacataggat gatcccggac aaatcttctg tctatgtatt tcattttttc ccgttccggc 2391601 acatagcgca gctcccataa tgtaaaggaa ccatcatgga caatatgcac ttttttgatt 2391661 cgcggctgtt tggcgtccac atagtctctg agtgtttgaa taaagttttg atattcctgt 2391721 tccatcttat attcatcaat cgctgcttct gtaatatctc tcagctgctt atagtatgat 2391781 ccaagtcgga aggtctgaaa ggagcgaatg taaaatactc cttcctctaa acagatcgtt 2391841 tggagttcat ccaaaattga ttgtttccgt gaaagcttca gcggctcaaa cggaagatcg 2391901 tctgcttcac cttcaataat actgtgtgcg agctgaagga tttgctgctg ttcatcctgg 2391961 tccgtgaaac aatacgtttc ctcaatcaat gacagcatat gctcgtcttc tttgcattcc 2392021 aaaaaaaatt tgaccagaat cggctccata aaacgctgaa taggaaaagc cggattcgct 2392081 ttttcaatcc cgatttttcg tatgccttca cggacaatga tattgttccg atcgtccgaa 2392141 tgctgaatga gatgtaaaaa agcggctgca tcatggtcat cttcaaagat tatttcaagc 2392201 atgtttgtcc ccccttacgg catctgttac aagtatatgg gggatgtttt taaaatagac 2392261 gtaaaggtca ttggcaaatc ttaatttgat tcttggaaca agttttgcat tttctttctg 2392321 aagatgaacg gcaatgagat aaacacgata tacaaagcga gcaccataaa gaaagcgggc 2392381 agattgccag ccaaaaagct cgcacccagc acattaagcg caatcgtccc agggatgatt 2392441 cccacagccg ttgcggcaaa atacggcagc gctttgacat tggaaaggcc tgccgcatag 2392501 ctgacgaaat caaaattgat cggcaggatt ctcaaaagaa agatatagaa aaatccgtta 2392561 tcctccattt gcttctgtat ggcttcaagc ctttcgtaat gcccgttctt tttcgccgaa 2392621 aacaaaccag ccgcaaaaaa cgaaacagct gaagcgcaca tcgaaccgaa taacgtataa 2392681 agcgtgccga gaagcgggcc aaacgcaagt ccgccagcta ttgaaataac agacaccgga 2392741 aataaaacaa gtggcctgac gatggatatc ccgataaaca tcagaggtgc aaagactccg 2392801 aacgacaata cccataccct gatttctttc ggcgatacat tcaaatacgt tttatttccc 2392861 caatagagta aaccagcacc tgcaagcact gccagccatt tgacagccgt ttttcgtttc 2392921 ataccctcag ttccttcccc tttgaaccac agcaattatg gatgtcggcg gttttctccg 2392981 tcaaggcgga tcggagcagc caaatataat atccgctcca ttaatcttgc agcttttact 2393041 tcttcttttt ctcccctctg cgaatacgta aaatgatgct tcagctcgtc aggtgagaaa 2393101 ttagaagaaa agaacgttgg cagctgctgg gacattctgt gctgaagcac cgttccgatg 2393161 acctcatccc ttacccagct tgtcattgat tctgctccga tgtcatcaag cattaatacg 2393221 ggtgtggtct ttaccatatt gagcttctct tccaatgtct ggtcttgcag cgaattctta 2393281 agctctctca caaattcagg cacataaaca atcatggagg aatactcttt ttccgccagc 2393341 tcattggcaa ttgcagcgag cataaacgtt tttcctaccc caaatttccc gtataaatat 2393401 aatcctttcc cttttcccgt ctcattatag cttttcagga agtctgtaac atgctgaaac 2393461 atcgcgagtc tgcttgggtc actgatatca acttgctgga acgtcgctcc aagaagatcc 2393521 tgctggatat acatgctttt cataagagac tgttgtttct tctgctggtc gagcttccgt 2393581 ttgactggac attcgtaata ctcgatatca atagacctcc cattgacaac aagcttcgga 2393641 tggtagccct ccaacaaatt gttgcagttt tcatcttccg aacaatagga gcaattcttg 2393701 ctttgttcga tatattcata aagcttattt aagctctttt cgatcatttt ttggtcaatc 2393761 acttcttcgt tttccttcaa aaatgcttga acatcttgat ctttcatgac tttttccttc 2393821 atttgttcaa gacgtttttg gaaatccggc ctgccggtta cgccctgcag ggaacggccg 2393881 attggttcca tctattcctt caccccgcat ctctgtcttt aataggcaga gtattttttc 2393941 agtttttgca tttcttccat catctttttc ttctgttctt ccaaatcctg cggatgcagc 2394001 ttctgctgtc cggattctga atcggacgct gtttcctttt ctgtcatcca atcaggaagc 2394061 ttttcttcac gaatcacttt ttggtttcgt ttcgaagact ttgtttttcc ctcagcccat 2394121 tcaagatact ggcggttttc ttctattgcg agcttcatcg cttccctgac cgttttcacc 2394181 tttttgcgtg cccaatgcga agcgattttt tggatatagt ttttcgacag cttcatgtcg 2394241 gttttcagca tgacataata aattaacaca tttgtgacgc ctggctcgag cttctgttcg 2394301 aacataattt cttctatgat cttcagatca gcttttgacg gctctgttcc gtcagcaatg 2394361 tcctgcagaa gcttcttcgg ggaaatcgcc tccagcaatg caatcagctt cccatccaga 2394421 gaatcctctt ctgccggttg ttcgccttca cgcagatgca ccggctgtgt tttttccacc 2394481 aaatcgggca gctgtccgtt tctttcaatt tgataccagt cgctcgccgc ttttcttaat 2394541 gcctccgtcg taatgacgtc acgctcatca attgcgctca tcacaacatt ttgcatttgc 2394601 aaagggtcaa ttccgtacag ataagaaagc tttttgattg tgtcccgcac ctgctgggtc 2394661 atcgcttttc tcggtatcat cgtctcagaa agtcccgcta aaaacaaatc aaaatcaaac 2394721 acatcctccg ttatggtgta ggacggagac tgtccgacag aagtatactc ggacccctcg 2394781 gcaagcctta ccgtttcctc catatcggat gtgagcttcc attcactcgg ctgcagcgat 2394841 tcaaacgcat gattaaacgg acgcgtaatg tccttcgcat cttctgaaat ggccgggtgc 2394901 gtaaaaaatt gttttaattg ctgatatttc gtttttccga ccctattata cagaaaaaca 2394961 ttcagcattc cgtcttcaaa aaattcattt ggtctgagcg gcggaaggag ttcatatata 2395021 aagaggcgct cctgccgctc ggattctttc atatatactt tcagcaatcc gatgccctcg 2395081 agcttcccct gttcctgatg gatcgttttt aagttggact gtgtcatccc catcagctgt 2395141 ctatgtgtgg actctccgcc ccacagacgg ttttgttcaa gctctcccca caatgtcata 2395201 taaagagaga atgcaacagg gccgattaag ggctggtaca gttgtgtaat aatttgtctg 2395261 tcaatatcct gcagcatcga tctgctttta accacatacg ggtctacagg cagtacatct 2395321 ttccaatagt cagccataca ttctcaaacc ttccgaattt gtttctacct ttcattttac 2395381 accgtttctt atatctatca aatgccaatt ttgcacatga gaaaagagct agaagaatcc 2395441 tcttagctct tttaacgctc tttctttatt aagtctttta attcatcgat aaagacgttt 2395501 atatctttaa actgccgata gacggacgcg aaccgcacat atgcgacttc gtcaatctta 2395561 gccagccggt ccatgaccat ttctccgacg agctcactct tcacctcgga gcagccttga 2395621 ttgcgaagtt ctttttcaat atcaaagcac atgtcttcaa gcgttttgag tgaaacaggc 2395681 cttttttcac atgcttttat gaggccgcgc agcatttttt ctctgctgaa ttcctcacgc 2395741 acaccttctt ttttcacaac gatgagcggg gtttcctcca ctttctcaaa ggtcgtaaac 2395801 cggtagtggc aggattcgca ctcgcgtctt cggcgaatcg actttccgtc atccacaggc 2395861 cgtgaatcaa ggactcgtgt tccgttatgc tggcatgaag gacatttcaa taaaatcagc 2395921 tcccaactat atcgttccct gcaatgtatt ttcggcagcc tccgcctttt aaaaatagat 2395981 gtgacagcat ctgtcgggag agccgttgtt aaatttgttt ctatagcatt aggtggtttg 2396041 tgaaaatctc cttcttattt tacaaaaaaa atgaaaaaag aaaaagctga cactctcgtt 2396101 tctttataaa aataaaagga gcataagcta aaaagcgcat aatggctttc tagcttcagc 2396161 tccctttgtg ttcgcaattt actttatagt actttcgctt gcgcctgttt aatttgcaca 2396221 ggccccattc ctcttggtat ttcaatgttt tctcttgtat cagcatgtaa tgcctctgca 2396281 atgtaatcag cagcgacatt aggatctaag tctccacaag tataaacatc aatgctcgca 2396341 tatccgtgct caggaaaact gtgaatcgtt aagtgtgatt cagaaataat cacaactccg 2396401 cttacgcctt gcggtgcaaa tttgtgaaat gcaacctcgc gcacctcagc acctgatttt 2396461 agagcagcat ttacaaacgt tttttcaata aaatccatgt cattcagctt atcaaaatcg 2396521 catccccata gctcggagat aacgtgacgc cccattgttt ccatagtcat ggacccccct 2396581 taacaagaat taaaaagtga aattccaaca actgggtcgg ccatttacca cgggggaaag 2396641 ttagtccgga gaggtcctaa ccctttaagt aattccgaaa cagtctcaag caagaagttc 2396701 acgaaaaata gtatactgtg tttaagtcta atttgcaagg tgcgtttttt cagaaatatg 2396761 ctgttaaggg ttttttcttt aaaatgtgtc catgacctta ttttatacag cagacggatg 2396821 tttcattcgt gccgctacat ggcggattag atcaacaact ctgcaggagt agccccattc 2396881 gttgtcatac cacgccagca cctttacttt cctgtcttcc attaccattg ttgtaagccc 2396941 gtcaatgacc gctgaatgcg gattcgtatt ataatcagtc gaaacgagcg gttcatctga 2397001 gtaatcaagt acaccgtaca tcgacgtttt ggcagcgcgt ttaaatgcct cgtttacttc 2397061 ttcagccgta acatccgttt tcagatcaac aacgagatca accaatgaga cgttcggaac 2397121 agggacacgc aaggcgaggc cgtgaagttt tcctttcaga tgcggcagca caagcgaaag 2397181 cgcctttgcc gctcctgttg ttgttggaat gatggattca ccgcaagccc gcgcccggcg 2397241 caaatctttg tgcgggttat caatattttt ttggtcattc gtatacgcat gaactgtagt 2397301 catcagaccg ctctcaatgc caaactcttc atccagcact tttacaacag gcgcaaggca 2397361 atttgtcgtg catgacgcat ttgaaataat gacatggcgc tcagcgtcga attggtcctc 2397421 atttacgccc atcacaatgg taacgtcttc attttttccc ggagcggtca aaatcacttt 2397481 ttttgcacct gcttctatat ggcccatcgc tttatcttta gcattaaact tccctgttgc 2397541 ttcgacgact atgtcaatat catattcccg ccaaggcagc tgttttggat cacggctgtt 2397601 taacaaaagc actttctttc catttacgat caggctatct tcaccagcca caacctcttt 2397661 gtcgtatctg ccgtgaattg tgtcatactt tattaaatga gccagcgttt ctgcggaata 2397721 gctggcgtta atggccacta cttgaatttg atcgtctaac atcgcttttc taaaaaccat 2397781 tcttccgatt cttccaaacc cgttgatcgc tacttttacc ttcatgttgg acacccctta 2397841 tcaattatgc catcctaatt tgttactatc taaaattagt ataacacatt aaaacaaatt 2397901 cgccagtaca tattgataaa aatcaacgat tataacgcta atttatgatg catcttatgt 2397961 tttcttgcac agaatatcag gcgtaagaac caaaaagcag ccagcgctcc gcactgactg 2398021 ccctcatgct ttatgattcc tgttttaact tatcattgag cacactttct tctagcacag 2398081 aaaatgtatc cccgtacact ctgttaatat gattcgctcc ccaagcacac agcatatcta 2398141 aaatcccttc taagctgcgg ccgtattcgc tgagctcgta ttccactttg ggaggaactt 2398201 gattatatac gattcggtta atgacaccgt ccgcttccag ctcgcgcagc tgctgagtca 2398261 gcattttttg cgtgatattg ggcattaggc gttttaattc acttgtgcgt ttttttccgt 2398321 gcgtcagatg gcataaaatg acgcatttcc atttcccacc gatcacttca agagtcgctt 2398381 caacagaaat gttatatttt ttcttctcca tacaatccat tctcctcaca ggcaccaaaa 2398441 agtgactata gcacttcaaa gtacgtactt ttatttctta acgatatgtt tcataatcac 2398501 atttgccggc tgatttgaat ctgctctttt ttatttatat agcttactcg gcagaatttc 2398561 aatcatacaa cacatcttac aaaggaggaa catcatgact tcagccaata aaagcaatat 2398621 tcctgcacta ctggctttgg ccgtaagtgc attcgcaata gggacaactg aatttatcag 2398681 tgtcggcctt ttgccgctca ttgctgatga cctggatatt cccgtcacga cagcaggatt 2398741 gaccgtttcc ctttatgcgc tcggcgttac atttggggca cctatattaa cttcattgac 2398801 ctcaagcatg tcacgtaaga cactattgct ttggatcatg tttattttta ttgccggtaa 2398861 tacgatggca gcaaccgctt caagcatcgg gattttacta gcagcacgtg tgatatcggc 2398921 attttcgcac ggtgtgttta tgtcgatcgg ttcgacaatc gcagcggata ttgtcccgga 2398981 ggataaaagg gctagcgcga tttcaattat gtttactggc ctcactgtgg caactgtaac 2399041 cggagttcct tttgggacat ttatcggcca gcagttcggc tggcgtttcg cctttatggt 2399101 cattatcgcc gtcggaatca ttgctttcat tacaaatggc attcttgtac cgtccaaatt 2399161 acgaaaaggg acgaaaacaa cgatgcggga tcaattgaag cttgtgacaa acagccggtt 2399221 attgctttta tttgtcatta cagcgcttgg atacggagga acattcgttg tgttcacgta 2399281 tctgtctccc ctgcttcagg aagtaacagg cttcaaagcc gggactgttg cagtgattct 2399341 gctcggatac ggaatagcta ttgctatcgg caatatgatt ggcggaaagc tgtcaaaccg 2399401 aaatccgatt gccgctttat tctatatgtt tatcgtacag gcaatcgttc tattcgtact 2399461 gacatttaca gccccgtatc aagcagcagg gctcattacc attctctgta tgggattgct 2399521 ggcctttatg aacgtgcccg gccttcaggt gtatgtcgtc atgctggctg agcgttttgt 2399581 cccgagtgca gttgacgtcg catccgcgat gaatatcgct gcctttaatg cagggatcgc 2399641 gcttgggtca taccttggcg gtgtgatcac cgattcaatc ggattgattc ataccgcttg 2399701 gataggcgga ttaatggtgg tcggtgcagt cattttaaca ggctggagcc gcttgatgga 2399761 aaaacgagat cggcaggaag cctgacaatt ttaaaggagg aaataaacat gacaacacat 2399821 ttacaagcaa aagcaacact tcataatggg gtagaaatgc cttggttcgg cctcggcgtg 2399881 ttccaagtgg aagaaggatc tgaactggta aacgcagtta aaactgccat tgttcacggg 2399941 taccgcagta ttgatactgc agcaatctat ggaaatgaag ctggagtcgg agaagggatt 2400001 cgggaaggca ttgaagaagc aggcatttca agagaggatc tgtttatcac atcgaaagta 2400061 tggaatgcgg atttaggcta cgaagaaaca ctcgccgcgt ttgaaacaag tctgtccaaa 2400121 ctcggtctgg attatttgga tctatacctc atccactggc ctgtagaagg aaagtataaa 2400181 gaagcttgga gagcgcttga aacgctgtat aaagaaggcc gtatcaaagc gattggcgta 2400241 agcaacttcc aaattcacca tcttgaagat ctgatgacgg cagctgaaat taagcctatg 2400301 attaaccaag tggaatttca cccgcgcctc acacaaaaag agttgataag atactgccaa 2400361 aatcagggca tccagatgga ggcttggtca cctttaatgc agggacagct gctggatcac 2400421 cctgtattgg ctgacatcgc tcaaacatat aataaatctg tcgcacaaat tattttgcgc 2400481 tgggatctgc agcatggcat tataacgatt cctaaatcaa cgaaggaaca ccgcattaaa 2400541 gaaaatgcaa gcgtatttga ctttgaatta acgcaggatg acatgaaccg aatcgatgca 2400601 ctgaatgaaa acttgcgcgt cggtcctgat ccggacaact ttgattttta atggccaaaa 2400661 aacaccgttc aatatgaacg gtgttttttg tattatgccc agctgttcat gatttcatca 2400721 agctgccttt tggtctcttc aagcgtgccg ctgttatcaa tgacttgatc tgctcttgct 2400781 gttttttcct ctaagggcat ttgagagcgg atacggctga ctgcttcttc ttctgtcagc 2400841 tgattgcgct tcatcagacg ttccagttga agctcttttg tcacactgac cacaataatt 2400901 ttatcaacca atgattccaa tttgctttcg aacaatagcg ggatatccaa tacaacaaat 2400961 gcctcccgat ttgcaacggc ttcatcacgg cgattgagca tttcctgcct gactgcggga 2401021 tgaacaattg catttaaagc gagacgtttt tgttcatttg taaataccag cgctccaagc 2401081 ttttttctat ctatatcgcc atttgagagc agtatgtctt caccgaattc gtcaatgatt 2401141 tgccggtagg ccggcatccc tttttctacc gcttgttttg caatgatatc tgcatctata 2401201 actgttattc ctttttcaat cagcatattg gctaccgtgc ttttgccgct agctattcct 2401261 cccgttaaac caatgactaa ggtcaagaga tccactcctt tttacaattt ccagagccca 2401321 atcgtgatta atagaagccc cggcaaaaac gccattttat cgatccattt ccacttagac 2401381 agaaaatggc cggcattgat tccaattgat acaaacagcg agctcatgat tgccacggcg 2401441 atgctcatca caatcggcga aaaaccgaga atggctgcgc ctatacctgc tccaaaggca 2401501 tcaatcgata aggcaaatcc caataagacc gcctcaattc cgttgatcac acccgatttg 2401561 tcgatatccg cactcatggg ttttctcaaa atatgaatca caattcctaa tgaccgaacc 2401621 tctagattaa gcagtgtttt ttcatgcaat aggtattctt tatcttttgc cggtttgaaa 2401681 aattgataca gaacccacgc accgattcca accaatatca aaccgccaag cttctccgtc 2401741 acatatacag gaaaaaactt cgtgagaaag cttccgatca gcatggatat aaacatgaca 2401801 gcaccggaac agcaggcgat aaccaaaatc gctttaaacg gtattttcat ttttctcaat 2401861 ccgtacgtaa atccgactga aaaactgtcc aagctgacag ccaacgccag cagcagtata 2401921 gaaaccattt gcatatccgt ttcttccttt ctgttggtgc tcttgtatca gatgtgaaat 2401981 gcccgggatt catcacaatc atatatatgg gaaagtgaaa aatccgtgtt tcgaaaatgg 2402041 catccttaat ccagagttac tgatatatgc accgacagct tggacaatga agcattatgc 2402101 tacttttttg tctggcactt tgcgcaaaaa tgcgtgcctc ttcctccaac gacaattttc 2402161 gaaatcatcg ttccgcaatt tttgcatggc tcgtcttttt ttccgtacac aaaatgctgc 2402221 agctggaaca ttccgatttc cccttgggag ttgatatatg aacggactgt gcttccgccc 2402281 gcatcaatcg cctcctgcag agtgtttttg atttcagcgt gaagggtttt gattgtttta 2402341 tctgataatt gatttgcttt tgtctcggga tggacacccg ctctgaaaag agcctcatcc 2402401 acataaatgt tcccgagtcc aactaccgtt ttttgatcca gtagggcagt tttgacagcg 2402461 cggtttgttt tcgcaagccg gtcttttaaa tacgcacttg taaattcttc tgcatccggc 2402521 tccggcccta actgagaaag cgggagctcg cccgcttctt ctcccggttt aaataagtgc 2402581 atggttccaa atttccgcac atccctgtac cggagctggg ttccatccgt catcgtgaat 2402641 atgacatgca cgtgtttatc gtcaggctcc tcggcttgat gaagaccgta ttttccttcc 2402701 attcgaaggt gagaaaccat aacataatga tctaaatgaa acagtaaaaa ctttccccgt 2402761 cttccgatgg actgtatcgt ttctcctgct agttttcgcg caaattcctc cggttcggca 2402821 ggccgtttga tgatattcgg ccatctgatc tctaccgatt tgattgtttt tccctttaca 2402881 agcccggtca gagtgcgccg gaccgtctca acctctggta attccggcac atccatcact 2402941 tcctatctct gtttatttcg catcgtacca agatgggcct gatgcaaagt ccacctttaa 2403001 cggcacatct aatgcaagcg catgctccat cacttcagga acaagctttt caagaatttc 2403061 aatttcttcc tttggcgcct caaaaatcaa ttcatcgtgt acttgaagca gaagccttgc 2403121 tttcaactgt ttttctttca gcttggcagc catgtcaatc atggcttttt tgataatatc 2403181 agcggcgctt ccttgaatcg gcgtattcat ggccgtccgc tccgcaaaac ttcggatatt 2403241 aaagttccgg ctcgtcagct cagggatgta gcggcggcga tgcataagcg ttgttacgta 2403301 tcctttttgt ttcgcttcct gtactgaatc ttccatgtac gcttttacgc cttggaagct 2403361 ttccagatag cggtcgataa atgctcccgc ttccttccgg gtaatgccga ggttctgtga 2403421 cagaccgtaa tcgctgatcc cgtaaacaat gccaaagttg accgctttcg cctggcgtct 2403481 catcgcagat gtcacttcat ccttagcgac atggaacaca tccattgccg ttttcgtgtg 2403541 aatatccata tcattagtaa aagcttcgat cagattttca tcctttgaaa tatgggcaag 2403601 cacccgcagc tcgatttgtg aataatcggc tgcaaaaatg agccagtctt tttcagacgg 2403661 cacaaaagct tggcgaattt tccgcccttc ctcaagcctg atcggaatgt tttgcaggtt 2403721 cggatcagtc gagctgagac ggccagtttg cgttaaggcc tggttaaatc gcgtgtgcac 2403781 tttatgcgaa tccggtctcg tcacctttaa aagcccttcg atatatgttg attgaagctt 2403841 gccaatttgt ctgtactgta aaatatagtc gacaatatca tgcttgtcag ccagcttttc 2403901 aagcacatcg gcagacgtag aatagcctgt tttcgttttc tttacgacag gaaggccgat 2403961 cttttcaaat aagatgacgc ctagctgttt cggagaattg atgttaaacg gctctcccgc 2404021 aatctcatgg attttttctt catattcctt cagcttcgca cccagttctt cacccatccg 2404081 ttttaaacgg tcaacatcga ccttgacgcc agttgattcc atttcgccaa gaataagcgc 2404141 aagaggcatt tccagctctt caaacagttc aagctggtcg ttgttttcca gctcttgaac 2404201 gagcttttcc cgaaggcttt gaatcgctaa cgcttttcgg ccaaggtgct cagacagtac 2404261 gtcttctgac ggcactgccc gttttgctcc ttttccataa actgattcat cacttgaaac 2404321 gatatgcagg ccgtaatcct tagccacact cgcaacgtcg tcatatgaat tgcccgggtt 2404381 gatgatataa gccgcaagga gcgtatcaaa ctcggctcct ttcagctcaa tgccctgcca 2404441 gcgcaaagcg acaacggccc gcttgctgtc gaagacccat ttcttctgct cgtcattttc 2404501 cacccattct ttaaacacct cagactcaac ggcaatgtct ttcggaatga aataagctcc 2404561 cgtttcattt acgatcgaaa atccgaggat cggctcttca tgataattat cgccaatctg 2404621 ttcaacgaca aatgcggatg gagaaaccaa tatatcgctt gtcacgtctg tgactgtttt 2404681 gacattaatg tcttccaacg attgatcctg ttctgcttct gcactgtctt ctccaagccg 2404741 ttcaagaagc gtgttgaagc caagatcttt aaagatggca atgacctgtt cacgattaaa 2404801 gccttgatat tccaggccgg aaacagatac ctcaatcgga gcatccgtca taattgtcgc 2404861 aagctccttg ctcatcaatg cctgatcctt aaactcctca agcttttcct tcaatttctt 2404921 tccgctcacc tcgtcaatgg actccagcag cttttcaacg gaatcaaatt gttttaaaag 2404981 cttaatcgca gtcttttctc cgacgccggg cacacccgga atattatctg aggaatcgcc 2405041 catcagaccc ttcatgtcaa tgatttgttc aggcgtaagc ccatatttct ctttgacatg 2405101 ctccggtgtg taaaattcaa catcggtaat tccctttctc gtaatggcaa ctgtcgtttt 2405161 gtccgttgcc agctgggtta aatccttatc tcctgagaaa accttaactt caaatccgtc 2405221 tttttcagcc gatttggcca gtgtgccgat aatatcatcc gcttcatatt gttccagttc 2405281 atagcggctg atctggtagg catccagcag ctcgcggata aacggcattt gttcggaaag 2405341 ctcaggcggg gttttctgtc tgccgccttt atattcttta aatgtgccgt gacgaaatgt 2405401 tgttttcccg gcatcaaacg caaccagcat gtgcgtcggt ttttcatcct caagcatttt 2405461 catcaaaatc atcgcaaagc cgtatacagc attcgtatga acacctttat cattgcttaa 2405521 cagcggcaat gcaaaaaacg cccggtaagc cagactgttt ccgtctacaa gcactaattt 2405581 ttttcgttcc gtcattcaat ttcctcctaa gaagcctcag gcttccattc atctcttaca 2405641 tagtcattag ctcctcttat tttaacaaag ttcaatttga aaggaaaata cgtgaactat 2405701 aagagaagac acaaaaaagg acgggaacac aaataggttc ccgccgtcaa aattggctcc 2405761 ttggatgaag gggttctact acatcctacc agcataggtt taacagtgca tgaagatatt 2405821 gttaaacctt tgtaaacatt aggcggactt ttcagcggcc cgtttcagcg tcacggtaaa 2405881 gacagttccc cgtccaagct cgcttgtgac atcaattttc ccttcatgag cctctattaa 2405941 atgcttgaca atcgctaggc ccagcccggt tccgcccgaa tttctgcttc tgtctttatc 2406001 tacacggtaa aagcgttcaa agatgcgcgg aatttcttct ttctgaattc cgattccaga 2406061 atcggcaacc tcaatctgaa tgtctttttc tctgggcttt acattgatag ccacggagcc 2406121 cccctcaggc gtgtaggtta atgcattgtt tacgagatta agaaatacct gtttcagcct 2406181 gtacgggtca ccagatacat attgagggtc tttcgggaca ttcaggtgca aggagatgcc 2406241 tttctcatcc gccttatgct tcagaagcgt ttcaatctca ccaagcattt tggccggctc 2406301 aaacgtttcg atactgagcg tgaaattttg ctgctcgatt tttgagagat cgagcaaatc 2406361 ctgaaccaaa gactgaagcc tttcgctttc cttaagaata atagagagaa attcagaaag 2406421 cgcctctttg tcttccatcg ccccgtccaa taacgtctcc gtaaaccctt ttatggacgt 2406481 aatcggtgtt ttcagctcat gagaaacatt ggccacaaaa tccttcctca tctgctctaa 2406541 tttcttcgtt tccgtcatgt catggaaaac gagcacaatt cctttccatt catcgtccgg 2406601 ccccataatc ggaacgccgt ccacttcaaa ataacgccgt tctattttga tcggcagtct 2406661 taacagcttg catttctttg tctccgtcat aaaaatgtct tcgacaagct ggatcacttc 2406721 ttcatgttca aatgcatcgt gataaagacg gcgcagcata tgattcggat tgatatgaaa 2406781 ctgcttggcg taagacctgt ttacgagatt aataaagcct cttccgtcga tcataatcag 2406841 cccggagcca atgttttcaa tgactgtcag cagccgatcc cgctgcattt cctgcgttcg 2406901 cgtcatttcc atcagatcaa tggcaaggct gttcatcgca tgtcctagct tatcagaacg 2406961 cctaatatag ccgccgtacg tccgtgcatc gtagttgccc ttagagagtt ctgtggctac 2407021 atttgtcgct gactcaattg accttttata acgtgaggtc atgctggaat aaaaataaac 2407081 aatgacgata aatgcggtac aaagactggc cgtcagcatc ccccacaatt cgccttttaa 2407141 gccgtcgctt ttttcagagg cggaaagcag cacatatcct gttttttcac cttcgcttct 2407201 aagtgaaagt ccgtaataaa gcttgttatc tgttgttgac agaataccct catggccaga 2407261 aacaagcgcc tgcacctttt gggaatcagc cgatctaccg tttgacccat acagcacctt 2407321 accgtctgta tcgataacgg atgcgctcac atcaagcgcg ccgcctgcat ctttaatgat 2407381 tttctcattt gcttgattat tcagattgcc ggcatcaaga agcgaagcca agtattttgc 2407441 ttctttttca atgtgttcct ctgctttcct ttgatcagat gtttcaaaaa gctgctgtaa 2407501 aaacagcccg aggacacaaa acaccagaat catacagaca acgaatacag aaaaaaggcg 2407561 cacacggtat ttattcattc atttttggct cctccagttt ataccccaat cccctaatcg 2407621 ttttaatgta gatcggtttt ttggtattgt tttcaatttt gtcgcgaaga tggctgatgt 2407681 gcacatcaac aattctcgta tctccggcaa aatcataatt ccagactgcg ctcagcagca 2407741 ggtctcttgt cagaactctg cctttatgtc tgcctaaata gagcagcagt tcgaattctt 2407801 tcggtgtcag ttcaagctga ctttctttaa agtacgcttc ataatgatca ggcaggattt 2407861 tcagatcgcc gattacgatc tggccttcca tttcatcgtt cttcatctca ctagagggcg 2407921 cagctatttc cgaacgcctt aaaatcgctt tgactctcgc atttacttcc cttggactga 2407981 acggcttggt catataatca tcagcaccga gctccagccc taatactttg tcgaattcct 2408041 catccttcgc tgtcagcatt aaaatgggaa acatcagttt ttgctgtctc agctgcttgc 2408101 atacttcgat tccgtccaat tttggaagca tcacatcaag cacaatcaaa tcaggtttct 2408161 ctgtttccgc ttttttgagt gcttcttccc catccgaggc ggtaatgaca tcatagcctg 2408221 accgttccaa attgtactgt aaaagagtaa caatagattc ttcatcatcc acaactaaaa 2408281 ttttcttgtt catgctgtgc ctccagtatt ataattcccc gacatcctat ttctctattt 2408341 tatgtcatct taacatgttt catgatttta ttttagcgaa agcaggacat tccgacaatt 2408401 cgccttttac atcattttta aaagaaataa agacgtttat gatagcgctt tcatttatag 2408461 taaaaagaga aaggctgtat taagcaagcc tttctctctt tttattagga taatactttc 2408521 atgacatttt tgacagattc aactgattta ttcagctgcg ctctttcata gtctgtcagt 2408581 tcaagttcaa tgatttgctc aagaccgttg ccgcctacaa ttgtaggaac accaaggtag 2408641 atgccttcat agccgtattc cccttcaaga taagcaattg taggaaggac gcggcgctga 2408701 tctttcaaga tcgcttcgac catttctgtc agagaagccg caggcgcata atacgcgctt 2408761 ccgtttccaa gaagattcac gatttcgcct ccgccttttc tagtgcgctc cacaattgcg 2408821 tcaatccgtt ctttcggaat aagagtttca agcgggatac cgccagcata agaataacgc 2408881 acaagcggaa ccatatcgtc accgtgtccg ccgagtacga aaccagtcac atctttcact 2408941 gacaggttta attcctctgc cacaaatgtt ctgaatcttg ccgtatcaag cacacctgac 2409001 tggccgatta cacgctcttt agggaagcct gattctttgt acaccgcgta tgtcattgca 2409061 tcaacaggat ttgtcagcac cacaataata gagtcaggag aatatttcac gatttcctgc 2409121 gtaacgcttc tcataatctt ttcgtttgta gagaccagat catctctgct cataccaggt 2409181 tttcttgcga taccggctgt aatgacaaca atgtcagagc cggctgtatc ctcgtaattg 2409241 gatgttcccg taatttttgc gtcaaagcct tgaaccgggc ttgcttcaag catatcaagc 2409301 gcttttccct ttgtcgggtt ctccaattgc ggaatgtcaa caagaacaac gtctgccagc 2409361 tctttttgag cgattaaaaa tgcagttgta gctccggtaa aacctgctcc gataacagaa 2409421 acttttttac gagtatttcc catgtctctc ttctccttta tggctagttt taggcttttt 2409481 ccttgcttag tccatgtttt tgatcagttc ttctccgaac tctgaacatt tcacttcagt 2409541 cgccccgtcc attaatctgg caaaatcgta agttacgact ttagaagcga ttgttttttc 2409601 catagatttg ataaccaaat cagccgcttc gttccatcct aaatgctcaa gaagcagaac 2409661 gcctgaaaga ataactgaag atgggtttac tttatcaagg cctgcatatt taggagccgt 2409721 tccgtgcgtc gcctcgaaaa tcgcatgtcc tgtttcgtag ttgatgttcg ctccaggagc 2409781 aatgccgatt ccgccgactt gcgcagcaag agcatcagaa atgtaatctc cgttcaagtt 2409841 cattgtcgca acgacatcaa actcgtttgg acgcgttaag atctgctgaa ggaaaatgtc 2409901 agcaatgctg tctttgataa tgatttttcc tgctgcttcc gcttcgcttt gcgctttgtt 2409961 ggcagcgtct tttccttgtt cttcagcaat gcggtcatat tgagcccatg tgaagacttt 2410021 atctccgtat tctttttcag caagttcata gccccagttt ttgaaggcgc cttctgtgaa 2410081 cttcatgatg tttcctttgt gaacaagtgt tacagatttg cggccatgct cgatcgcata 2410141 atcaatggca gctctgacca agcggcttgt tccttcttct gaaacaggct taatgccgat 2410201 acctgatgtc tcagggaaac ggattttatt gacgtttaac tcattttgaa ggaagctgat 2410261 aagcttttgc acttcttcag agccttttgc atactcgatg cctgcgtaaa tatcttctgt 2410321 attttcacgg aagatgacca tatcagtatc ttcagggcgt tttaccggtg acggcactcc 2410381 agtaaagtat cttacaggtc ttaagcagac gaataggtca agctcttgtc tgagcgctac 2410441 gttcaaagaa cggataccgc cgccgacagg tgtcgttaac gggcctttaa tcgcgatgaa 2410501 atattcgcgg atcacatcta atgtttcagc agggagccac tcacctgttt tattataagc 2410561 cttttctccg gcgtaaactt ctttccatgt aattttcttt tcgcctttgt atgctttttc 2410621 tactgctgct tccaaaacct tcgaagccgc gttccaaata tcaggaccgg ttccgtctcc 2410681 ttcgataaat gggataatcg ggttgtttgg tacgtttaat actccgttag agactgtaat 2410741 tttttcacct tgtgccacaa taaaaacctc ccagtatgta attcatattt agaaaacatt 2410801 ttatttttct tatatagaaa ataaaatgat ttttcctaac attcaattta aagtgtaacc 2410861 caattttgat gtctgaacaa gaggctaacc tcattgacgc aagccagcct ccaatggttc 2410921 tttaggctct ttcttcaatc ggaacgaatt tttgtttgtc agggcctgtg taatctgccc 2410981 gcgggcggat cagacggttg ttgtcatact gctcaagaat atgagcgagc cagccggaca 2411041 ttctgcttac agcaaaaatc ggtgtaaaca aatcatggtc aataccgagg ctgtgatata 2411101 cagaagccga atagaaatca acgttaggcg gaagcttttt ctctgatgtg acgatgtctt 2411161 ctatacgaat cgacatctca taccatttgc tttcgcctgt caggttggtc aggcgcttgc 2411221 tcatttcttt cagatgcttc gcgcgcggat caccatgctt atacacacgg tggccgaatc 2411281 ccatgatttt ttctttcttt tcaagtttag cgcggatgta cggctcagcg ttttccactt 2411341 caccgatttc tgtcagcatt ttcataacgc cttcattcgc tccgccgtga agaggccctt 2411401 tcagcgcgcc gattgctgca gtaatgcctg aatagatgtc agaaagtgtt gcgacgcaga 2411461 ccctcgctgt gaacgttgac gcgttcagct catggtcagc atgtaaaatc aatgctttgt 2411521 tgaaggcttc aacttcaatt ggtgaaggct cttcaccgtt taatgtgtaa agaaaattct 2411581 ccgcaatacc gtaatcttct ctcggttcaa caggctcaag acccttgcga attctggaaa 2411641 acgctgcaac caggccaggc acctttgcct gaaggcggat cgcctttctg tagttggctt 2411701 ccgggttcat ggtatcagcc tcgctgtcaa gcaggcctag taatgaaatt gctgtccgaa 2411761 gagcagccat gggatgaaca ttttcgaggg aataagattt gaagtgctca ataatttctt 2411821 gcggaacggc agcttccttt gcaagctgct gctttaactc ttcaagctct tttttgtttg 2411881 gcagccttag atgccaaagc aagtagatga tttcttcaaa acttgcattc tctgtcaaat 2411941 catcgatatc ataccccaca tatgtaaggg tatcatcaat aatagaacta acagatgatg 2412001 ttgttgctac aaccccttca agaccgcgtg tcgctgtcat atataacatc tccttttcaa 2412061 taaatttccc ctttaagagt gttgtaaaaa catgaggctt acttaaaaag cacgatgcaa 2412121 gtatttctct cccccaaaaa gaaaatgctt acattttact ggctgctgga actaaaaccc 2412181 tttgcttttg aaagaacata acaaattttt ataagcttat ttaagtttaa gcctattctc 2412241 attataaaca ataatcagac atttgttaaa tgtttaccta taattttttt tttccattct 2412301 gtgatttccc cgaaaaaacg cctttatttg cgggtttttg cataaaaaaa agcggcttta 2412361 aggccgcttt tttttatgaa gtgaacagtt ttacgatctg catggctaaa taagcaatcc 2412421 ccgctccgat cagcggcccc accgcaactc ctccaaaaag cgcgactgca agaatggtcc 2412481 cgatcacgag agcagttgta atatgcggat cattttcaag cagggtcagg ccgttttttg 2412541 caatcagcgc cactgcgatc cccgctccaa gggcgatcca tgcgtaggaa gaccgcattg 2412601 cttctccaag ctgcttaaat ccgatttctc ccgtggcaat cgggacaaga acggcgatgg 2412661 taataatggt cacaccccag ttaatgcctt ttgactggat ggtcggaaat aatttctgat 2412721 caagcccaac gattttgatg atcaaaagga cggatacagc aaagagcaat gattggtttt 2412781 ttgcgataag tgcgatagcc aagagtaaaa ttaaaaataa attcgcttgt gtaaacacat 2412841 gccatccctc ctttaagatg aatgtattca tattcagccg cagcgtgaat acatataaaa 2412901 aataggacat gctgacgaga ggaggaccgt ttttgtgaat caatcttata tcactatttt 2412961 tttcagaacc ctctttgtca tatcaatgac cgcagggtcg atagctgcgg cctattattc 2413021 gtttccgtta acttatccgt tcctgatcgc ccttattcta tcttcagtga ttcatcctgt 2413081 tgtcgattat ttggacaaag tgacaggatt cccccgaacg ataaatgttc tgggcgttct 2413141 tgcttttttt ctgctcgcag ccttcggcgt gctcaccatt ctggtagccg aaatcgtaac 2413201 gggaacagcc tatctagcaa aaacgctgcc tccgcatatc agcacgttta tttcatattg 2413261 cgaaaaattg tttaccactc atattcagcc gctctataac gagttaactc ttttgtttca 2413321 agaattggaa acgaaccagc aggcttccat cgtcactcat atccagacac tcggtgattc 2413381 tgccgctaaa aatgccgggc tcctgctgtc ccacattcta gagatgatcc cgagattttt 2413441 cgctcttctt cccaatacgg cggcggttct gattttttct cttctggcaa ccttttttat 2413501 gacaaaggat tggcataagc tgaaagccat gcttgtttta attctgccgg atcgtgtgac 2413561 agctaacagc aaagcaatca gcagcgaatt aaaaaaagca atgactggtt ttatcaaagc 2413621 acaagccgtc ctcgttttca tcacgatggt gattgtattt atcggccttt ctctcttaaa 2413681 ggttgaacac gccgcaacaa ttgctttttt aatcgggctt gtagatcttc tcccttactt 2413741 aggtgccggc tccgtatttg tgccctggat tttgtattta tcgattacgg gccagctgcc 2413801 ccaagcaatc ggaattggta tcctgtacct cgtcgttctt attcagcggc agctgacaga 2413861 gcccaagata ctaagtaaat ctatcgggat cgatccgctg gcaacactca tcgccctgtt 2413921 tgccggcttt aaattattcg ggtttttagg actgattgcg ggaccggctg tactcgtcat 2413981 catccaagct ttcatcacaa caggcgcatt aaaagaaata tggtcctata tcaccgttca 2414041 gcaaaaataa aacggcagcc gttttttcat ggctgccgtt ttttatttga tgatgatccg 2414101 cttattcttc gacattcctc tcagccattt gaacagaatc ggcttacacc agccgcgggt 2414161 aaacgggata agaagacagg cgccggccaa atctgataaa aagcccggaa gcatcagcaa 2414221 tagaccgcca atgaaaatgc acagaccgtc agcaatcgct tctcccggca ttttgccata 2414281 ttgaagatca cgctgaacct tataatacac ttcggttcct tgtttttttg cagctgctgc 2414341 gccgataatg ccagtcagaa tcatgaatag aactgtcggc aaaataccaa tcagatttcc 2414401 taaaaatagg aatataccga tttctattgc cggaaacaca ataaaaagca aaaacaaaaa 2414461 tctcatatcc aagcccccca cacgtgtaac acgttctgtt caacaaaagg catgataaag 2414521 agaaaaggaa gggattcccc ttccattttc acctgtaatt aaagaacgct cgcacggcct 2414581 tgatagactg cgcctctgga agcgtcaact gtaatatcct ggccatctgt caaaatagat 2414641 gtcgcatttt ccagacccac gataaccggg atgccaaggc ttaatccgac taccgcagca 2414701 tggctagtca aaccgccttc ttctgtaata agagcagacg ctttttcaag ggatgcaatc 2414761 atatcacggt cagtgctttt ggtaacaagt accgcaccgt cagtcatttt ttgctcagct 2414821 tcttttgcat tttgtgcaac gacaaccgga ccgtaagctg atttgcgtcc aatgccttgg 2414881 cctttagcga tgatatcgcc gacagtatga accttcatta agttcgtagt gccggactca 2414941 ccgacagtgc cagctgtaat aacgataaga tcgccgtgtt ttacaattcc gctgttcaat 2415001 gatttttgga cagcatcctc aagcatctca tctgttgagc tcgcattttg gccgctttcc 2415061 gcgaatacgc cagatacgag ggcaagcttt ctggaaatag agtcatttac agtaaccgca 2415121 acaatcggag cctgcggacg gtattttgca atcatacgtg ctgtatggcc gctttctgtc 2415181 ggcgttacga tcgcagcagc attcaggtta atcgccgtat gtgcgacaga ttgtccaatt 2415241 gcgtctgtaa ttgtcatgcc cacttggtct ctgcgttttg agagaatttc tttataattt 2415301 aatgcttctt cagaacggga cgcgatgtta tgcattgttt gaactgcttc aaccgggtaa 2415361 cttccggcag cagtttcacc agaaagcatg atcgcatctg ttccgtcgaa gatcgcgttt 2415421 gcaacgtcac ttgcttccgc acgagtcgga cgcgggttgc gctgcatgct gtcaagcatt 2415481 tgtgtcgctg taataacagg tttgcccagc gcgttgcatt ttttgatcag ttctttttgc 2415541 acaagcggca cttcttcagc tggaatttcc acacctaagt ctccgcgtgc aaccattaag 2415601 ccgtcagaca cttcgagaat cgcatcgatg ttgtcaacgc cctcttggtt ttcgatttta 2415661 gggatgattt gaatatcctg agcgttgtgc tcttcaagaa gctcacggat ttcgagcaca 2415721 tccgtagaac gtcgaatgaa agatggtgcg atgaagtcta ctccttgctc aataccgaaa 2415781 acgatgtctc gcgcatcctt ttcagtaatc cccggaagat tgacacttac gcccggtacg 2415841 ttaacacctt ttttattttt gagtgttccg ttgtttaata cttttgtttt gatttcgcgt 2415901 ttagcggcat ctacatcaag tacctcaaga ccgataaggc cgtcatctaa cagaatcgtt 2415961 gaaccttgtt caacgtcatg gactaaacct tcatatgtca ctgaaatttt atctgttgtt 2416021 cctacaacct cgtccattga aataatgagc tctttgcctg tttcaagctc aataccgccg 2416081 ttttccattg tatgtgtgcg gatttcagga ccttttgtat caagcagaat tccaacgttc 2416141 ttgccaagtt ttttacttgc ttcgcggata tttttaattc ttgcaccgtg ctcctcaaaa 2416201 tctccgtgag aaaagtttaa tcgagccacg ttcattcctg actccattaa tttcgtaagc 2416261 atttcaatac tttcacttgc cggaccgatg gtacaaacaa ttttagtttt tctcatttgg 2416321 ttcacttcct tctgaaatct tcagccttca gctgtacatt agatagacag ttcttttgaa 2416381 agctgataca tgttttgctc aactgtgtgt tttgtctcaa gtatttctat aatatcatgg 2416441 tctacaagct tattgttttg tatacctaca cagcgtccgc cttttccttc aagcagcagt 2416501 tcaactgcat atgcgccgag acggcttgcc aacacacggt cagcagcact cggagaacct 2416561 ccgcgctgga tatggcccaa tacagatacc ctagtttcaa gatttgtttc ttcttcaatg 2416621 cgtttcccga attcaacacc gctgcctaca ccttcggcaa caataataat actgtgcttc 2416681 ttgccgcgtt cgtggccgcg ttttaagcgg gcaatgattt cgtgcatgtc atagtctgcc 2416741 tcagggatta agatcgattc tgcgccccct gcaagaccgg cccacaatgc gatatcgccg 2416801 gcatgacggc ccattacttc gattacatat gtacgttcat gagaagtcgc tgtatcgcga 2416861 atcttatcaa ttgcgtcaat tactgtattt aaagctgtat cgaaaccgat tgtaaaatca 2416921 gtgcccggaa tgtcattatc aattgtaccc ggtacaccta cacatggaaa cccgtgttcc 2416981 gttaattttt tcgcacccat ataggaaccg tctccaccga taacaacaag gccttcaata 2417041 ccaagcttct tcaagtttgc tatccctttt tcacggcctt caactgtttt gaattcagga 2417101 catctcgccg tataaagctt agtccctcca cgatgtataa tatcgcctac tgatccgagt 2417161 tcaagctttt caatctttcc gctgatcaat cccgcgtatc cgttgtaaat accgtaaact 2417221 tcaacgtcat gatagatcgc ttttctgact actgcgcgaa ctgctgcgtt cattcccggg 2417281 gaatccccgc cgctcgttaa tacccctatt cgtttcattc tccattcacc tcagcaacat 2417341 atatgattaa acataacatg atcattgccc taaaaacaat gaaaagggat ctccatcctc 2417401 cctatgaaac cttacctatt atacaattaa ataaattgtt tttaaataaa atttaaggaa 2417461 tgtcacaaaa aataaacgtg agccaaaggc ttcacgttta tttagtttac cccgatatat 2417521 tgatcttcaa ccgagacttt gccaattgct ttatattttt cataacgctg ctgaactaat 2417581 tcttcttcgc tcagcttcag taaagttttt aacgattgtt taagggtttc gtccatatag 2417641 cttgcctgca gcttcacatc atggtgcgct ccgcctttta cttctttaat catatgatct 2417701 ataataccta attcttttaa atccggcgca gtgattttca ttgtttctgc tgctttttta 2417761 gcaagactgg agtccttcca taaaagtgcc gcggcacctt ccggagaaat aacagaataa 2417821 gtagagtttt ccagcatatg caagtgattg cctacaccca gaccaagggc tccgccgctt 2417881 ccgccttcac caatgacgat gcagataaca ggcactcgaa ggccggccat ctcaaacagg 2417941 tttttggcaa tagcttcact ttgtcctctt tcttcagctg ctcgtccagg gtatgccccc 2418001 ttcgtatcaa taaaacagat aattggtctg ttaaatttgt cagcctgttt catcagacga 2418061 agcgcttttc tgtagccttc tggatgcggc atcccaaaat tgcggactag gttttccttc 2418121 gtgtctttgc cgcgctgatg cccgattacc gttacaggga ggccgtggaa cttcgcaatc 2418181 ccgccgacaa tggcttcatc gtccccgtac gctctgtctc cgtgacattc aaaaaagtcg 2418241 gtaaacaggt gttcgatata atcaagagtt gtcggacggt ccgccagacg cgcgatttga 2418301 acccggtccc acggcttcaa atttttgtaa atatcatcct gaagcttagc gagacggtct 2418361 tcgagccgtt cgatttccgc acttagatcc atatcggaat cttgggtgaa tttttttagt 2418421 tcggcgattt tggtttgcag ttcaatcacc ggtttttcaa attctaatct tggagccact 2418481 caatgtcacc tcctgtttga tgcatatcca gcagattttc taacgttttt ttcatatcgt 2418541 cgcgatgaat aaccgcatca agctgtccat gttttaataa aaactcagcc gtttggaagt 2418601 cctcaggcag tttttctcct attgtctgtt caataatccg tcttccggca aaaccgatca 2418661 gcgcgccagg ctcagcgaaa ttgtaatcgc caagggatgc aaagcttgct gatacgcccc 2418721 cggtagtcgg atgcgtcatt actgaaataa taagaccctg ttcttcactg aacagtttta 2418781 acgcagagct tgtctttgcc atctgcatca aacttaatac gccttcctgc attctagcac 2418841 cgcctgaagc cgtaaaaata ataaacggaa ctttatcagc ttttgctttt tcaatcgcaa 2418901 gcgtgatttt ttcaccgacg actgaaccca tgctgcccat tctgaatgaa gagtccatga 2418961 cggcgacaac agccgggtgt ccgccgatgg tgcccttgcc tgtcacaaca gcctcgttta 2419021 aggatgtttt ctcgcgatct ttttcaagct tttccagata tcccgggaaa ccaagcggat 2419081 tttccgagag cattccctga ttaaattcct caaaggattg ttcatccatc aagctttcga 2419141 tacgctgttt tgcgttcatt gggaaatgat aatcgcagtt catgcatacc cgcatatttt 2419201 tatccaactc tttagtgagc atgatttttt tacacttagg acattttgtc ataatgcctt 2419261 ccggaacatc gtgcttcgct tgatcagacg gtacggaagc atactttttc tttttcgtga 2419321 atatatcctt taacaaatga ttacctccct tttgtgaagg gttctcttca ccgcatgtca 2419381 tcaaacagat agacttgcta ataactttac cgaaactatt gtactttttt tgtcaaacgc 2419441 tgtcatcctc aattcgacaa ctttttattc gatgacgtgc tcggaaaggc ttgtatgaaa 2419501 tcagataagg tgttgaaacg acaaggttga cagcgcattc aaaaataatg ttaaacccgg 2419561 ctgaaatttt tttaaggcta accccctaaa aaaatttcag ccgtcagttt aacttgagaa 2419621 cagcgcgccg gtctccgcca acgcgctgcc atttttggaa tgaattaaaa ttattcacca 2419681 ataatcgtaa gttttcttgt tttttctgcg acttcctcag ggtcaacagt gattcttgca 2419741 acacctgttt ccatcgcagc ttttgccaca gccttcgcaa cagcaggcgc aacacgttta 2419801 tcaaacggtg cagggatgac atagtctgcg ctaagctcat cttctgaaac cagtgaagca 2419861 atggcttcaa ccgctgcgat tttcatttcc tcgttaatat gagtggcacg cacatcaagc 2419921 gctccgcgga aaataccagg gaatgcaaga acattgttta cttggttcgg gaagtcagaa 2419981 cggccagttc cgacaacgct tgctccggct tcacgcgcat cttccggcat gatttccgga 2420041 tttggatttg ccattgcaaa gataatcgga tcttttgcca tgctttgaac catttctttt 2420101 gttaacgcgc ctgctacaga gacaccgata aatacgtcag catcaacgat aacatctttc 2420161 agagaaccgt ctttgcgatc ttggttcgtg aacttcgcca cttcattttt gacatcgttc 2420221 atgccgttcg ggcgcccttc ataaatggcc cctttggaat cgcacatcac aatgtcgcga 2420281 acgccataat gatgaagaag cttgataatc gcaatgccag ccgcacccgc gccgtttgcg 2420341 acaactttaa tggatgacat ggattttcca gacagtttca gcgcgttcac aagacctgct 2420401 acggttacaa tggcagtacc gtgctgatca tcatggaaaa ccgggatgtt tgtttctttt 2420461 ttgaggcgct cttcaatgat aaagcagttt ggcgctgcaa tatcttcaag gttgacgccg 2420521 ccaaatgtcg gttccagcaa ttttacagtt tcaacgattt tatcaacatc gtttgtgttt 2420581 aaagcaatcg ggaacgcatc tacgcccgca aagcttttga aaagaactgc tttcccttcc 2420641 ataacaggaa gcgccgcttc agggccgatg tttccaaggc caagcacagc tgtaccgtca 2420701 gttacaactg ctaccatgtt ccccttcatt gtataatcat atactttgtt aatgtcttca 2420761 tgaatatcct tacacggttc tgcaacaccc ggagaatacg cgaggcttaa atctttcgca 2420821 tttctgacct ctacttttga tttagactcc agtttcccct ggttgacttt atgcaggtgt 2420881 aatgcttctt ctcttaatga cattctccta aacactcctt atggatattt tttgattcgt 2420941 atactgctgc gttgattgct gcattctgcg gagtaaatct atctgaatat ttaaacagga 2421001 tcacataatt gctccaattg tataacaaaa agcgaatcgt taccactgtt ttaaaacgac 2421061 gtttttttga cccaacagct cttttaagcg atataacacc tggtgatctg cattgatatg 2421121 gaacgactca ggtagcttaa tcgtctgttt ttgcctttca taatagagat aaacgcctgt 2421181 ttccccttta tgctccagca aaatgcgctt aatctttgcc aggatctcct ggctgtgctg 2421241 actgctttct atttttatat aaaccgatgg cgctttttct gcatccatat cttctaataa 2421301 ttctgcccgg gacatgatga attggatctt atcttgtcta acttcacatt tccccgcagt 2421361 gaacaaaaga gcgccttctc ttaaaacggg agaaagctgt ctgaattgtt cagggaagac 2421421 tacggcttcc atctcgccgg tttcatcact gagcgttaaa aacgccatgt tttgacctgt 2421481 tttcgtccga atcgttttga tcttcgacag cagaacgcct agtgaaagct gccttttgac 2421541 tgcccgctga gcctgcagaa tggagactgc tccttgcgca gtgagctgtt ttcggaaggc 2421601 ggagagggga tgatttgaaa aataaatgcc aagcgtttcc ttttcaaacg caagtaaatc 2421661 caccagagga agctcctccg tctccacata cttcggctta attgaaaacg attcatctaa 2421721 aaacaatccc atttggtcat cgtccgcggc gaatagctca gcatgttcca aagcaacatc 2421781 aatggatgcg agcagcgtgg cccggttttg gccgaattcg tccatcgcac cagaaaagat 2421841 aagtgcttca agcattttgc gatttacgct ttttgacggc acgcgaaagc agaaatcgaa 2421901 aagatcttca aatggtttct cttttcttgc tttatatata tctttgactg ctgagacgcc 2421961 tacacttttt atcgcgcgga ggctgtatct gacagatccg ttttcaactg taaacggaaa 2422021 actgctttta ttcactgacg gaggaaggat acgaatcccg ctcccctttg cttcgtaaag 2422081 atattgagag attttatcct cattgccaat gacgcttgtc agcaatccgc acataaaata 2422141 taacggataa tgagctttca aatacgcaag ctggcacccg atcatgctgt atgccaccgc 2422201 atggcttctg ttaaagccat agtttgcgaa tttgacgatt aaatcgtaga cctcatttgc 2422261 agtgtctaca gaatactcct tttttaagca cccttcaaca aaatggcttc gctctctgtc 2422321 caggatttct tttttctttt tgctgaccgc ccttctcaat aggtccgctt cgcctaaaga 2422381 aaaccccgcc atacgggaag caatcatcat aatttgttcc tgatacacaa tgacgccata 2422441 tgtatcttcc aaaatgctcc ttaaatcttc atgaggatag tgaacaggcg cccgaccgtg 2422501 tttacggtcg ataaataacg gaatattttc catcggaccc ggccggtaca gtgcattgac 2422561 cgccacaata tcttctaggc ccgaaggttt cagccgtttc aagacgcttc tcatccctgc 2422621 agattcaagc tggaaaatgc ctgtcgtatc cccttttgac agcaaggaga acgttttgtc 2422681 atcgctgtag gaaatacttg aaaggtctat tttaatattt tcttcttttt caatcattga 2422741 agtgatggat tcaataagtg tcagattcct caaacctaag aaatccattt ttaaaaggcc 2422801 caagtcttca agatggtcca tcgcgtattg cgttaaatag atcccttcat gcccttcttg 2422861 aagcggaaca acatctgtta acggttcttc actcaggaca acgcccgctg cgtgggttga 2422921 tgcatgcctt ggcagccctt ctattttccg ggcaattgaa tagacttgct gaagcaggct 2422981 tgactcccga agccgcttat ccagctgcgg tgactgctgt ctcgcttcat ccagcgtcat 2423041 tcccggtctt gaaggaatga gttttgcaag ctgatctgcc tccttcgggc tgacgccgaa 2423101 tactctgccg acgtcccgga gcgccgcctt tgccgcaagt gttccaaagg tgataatctg 2423161 tgcgacgtgc attgcaccgt atttctgctg aacatattga atgacttcat cccttctagt 2423221 atcgggaaag tcaatatcaa tatccggcat gctgacgcgt tcgggattta aaaatctttc 2423281 aaacagaagg tgatgcttaa tcgggtcaac atctgtgata tacagcacat atgccacaag 2423341 agaacccgcc gcagaacccc ttcccggtcc tgtaacaatc cctttttcat gggcgtgctt 2423401 cataaaatcc cacacgatca gaaagtaatc gctgaacttc atccgcttga tgacatcaag 2423461 ctcatattga agacggcgaa ggtatcgttc atcaggcttg ccgaaacggc tgcggagtcc 2423521 ctccatacag atatccgtta aataatcatc agcggacgtt ccgtctgggg tcggaaaaga 2423581 cggtagacgg gtctgcccga gactgacgtc aacccggcat tgttccgcga tctctacaga 2423641 agcttgcagt gcctcgggat gctctcgata aatgttttgc atttcttcga gtggtttcaa 2423701 atcgagatca ggcaaatctt cagcgggtgc atccgtcagt ttttcccccg ctttaatcgc 2423761 tttcaaacaa cggtaggcag ccttatcttc cttccttatg taatgcacat cgcctgtggc 2423821 cgtaacaggg atacccgttt cttctgacag ctttagaatc tgctcagaca agacttgatt 2423881 ccctttaaaa ggctgatagg agaaataaaa agctcccttt ccgaatatag actgaaattc 2423941 cagcgaggct tgagcagcct gttcgaacag ccctccttca agaagcgttt caatatatcc 2424001 tttttcgccg ggcgttattg cgataatccc ttctcgataa ctgtgaagcc atttcggctt 2424061 cagtccgcct tttgatttag attgcagaac gctgctgatt ttcagcaggt tttgatagcc 2424121 tgtattcgat tttgccagca ggacgagcgg gtatgcttca agctcgctgt catctgtaaa 2424181 aacagaagcc gtcaaaccga ttattgggtt gatccctctc gccttgcaag ctttataaaa 2424241 ttgaatagct ccgtacatga catgatcatc tgtcagcgcc aaagacgcat atccgagcct 2424301 gtcagcttca ctgacgagtt cttccacagc cgcggcgctg tttagcaggc tatacccgct 2424361 atgcacttgc aggtgaacaa aagacatgct atcacctctt tctcattacg atccatttct 2424421 tccttcatta taaggccggt ttccaaaaga aacaaatgtt cttttttgac tcatcatcat 2424481 acttgtcctg aaagctcaat atgatataaa aggtgaggtg ataaagatgg atcaggaagc 2424541 aggatttatg gtgaatttta tcaatagcta cttcattgcg ttaggggtgc tgatcggggg 2424601 cgcactcatc ggagggctcg gagcatactt ggcaggcgaa cccccgctta cagccattac 2424661 aaagcttgcc aaccggttaa aaatatgggc gcttgtcgca gctatcggag gcacctttga 2424721 tgcggtatac agctttgaac gcggcatact cgaaggcaat acgagagata tctttaaaca 2424781 gcttctttta attatttcgg ccatgggggg cgcgcaaagc ggctggctta ttatatcatg 2424841 gctgacccag gagcatcttt cttcatgagg gtcccccagc attacaaaaa accgggatgg 2424901 cagcgttttt tcgcgggaat gatgtgcgga gccgtaatca gctggttctt tttcctgttt 2424961 acttacggaa cattccaaga ggagcaggtc agcctcatcg aaaagcaaaa agagcatgta 2425021 aaagacttga acaatcaaat ttcgatctat caggaagacc tccataaact gaatgaagat 2425081 aataaaagaa aactgctgat tcaaagcgtc agcgtcaaat tgctgaatgg ggataaatat 2425141 aaaatatcac agccggataa aacgaaattc gaggagcatg taaaggatga tatttcagag 2425201 gtgattacaa aagacataga gagcgtctat caaacaaagg atctcttgaa gcggacaatt 2425261 gaaaataaag tctatatgat caatgaaaaa aaatacgagg caaccgtcag agaattgatt 2425321 atttatacga ggctgacagt ggaacttgaa atttctttcg ccacataatt atggattttt 2425381 tttaaattct ccaaacttct gtcgcttttt cccattcttt tttataaact atatgtgagg 2425441 cttaatggcg aaaggaagga ggaagggaaa tggaggttta cagtgaccgt cagttagcaa 2425501 aagatcaagc agcccgtctc agacaaggtt tttctgcata tgccgaaaca aactcactcg 2425561 cttccctcat caaaaaagaa cttcaatcac acaatctcca agtctacgag gaccttactg 2425621 atttcggctg ctggttcatc cccgtcacag atgaacacta agagagaggg tctcccctct 2425681 actcgtgttc tttacataat gtttccagat cagctaaaat acgatcagct tcatcccagc 2425741 tgtaaataga ggcgcctgaa gctaacggat gccctccgcc gttatatttc cgggcaagtc 2425801 cgttaatgac aggccccttc gaacggaatc tgactctgat ttgatcgtct tcttctacga 2425861 aaaacaccca ggcgcgaata cctgagatat tgccaagcgt cccgacaagc tgcgacgctt 2425921 cagaagccgt tgtgccgaat ttttcaagcg tatccttttt gatgaaaaca gaagccgccc 2425981 cgttttcgga caaagacaca ttttgaaaga taaagccgtt aagcttcacc acattcagtt 2426041 ttgtttcata caattgatta aataactctg aggaagagaa tggatactga atgagctcgc 2426101 ctgcatattt tagtgttttt tccgtggtat tcggaaataa aaagcgtccg gtatctccaa 2426161 caatgccggc gtagatcagc tctgccgctt tcgtattcag cttccagccg tgctcttttc 2426221 cttctaaata cagctcgtaa atcatttcac ttactgagct ggcgcttgta tcgacccaga 2426281 gaaggtcacc gtatggatct tcgttcggat ggtggtcgat tttcattagt ttggcgcctg 2426341 aaggataacg ctgatcgtcg attctttcct gatttgccgt atcgcagaca atgacaagtg 2426401 cgccttcata tgtttcattg tccacctcat caagggaata taagaaagag agggacggtt 2426461 caggcgtgcc gaccgcaaaa atattttttt caggatatgt ttcacgcagg atttccgtaa 2426521 gcccacactg tgatccgtag gcatccggat caggacgcac atgtctatgt aagataatcg 2426581 tgtcatataa tgatatggtt ctgatcaatt ctgttttcat ttgatactcc tttattgttt 2426641 ttattcatta aatcacattc tctgccgacg gaaaagaaaa ataacgtcaa aaccaagccc 2426701 gtttttgtat aaaatggggt tgtaaacttt tacgatggag gatttcattt atgctggttc 2426761 ttgttttttt gattgggctt tcagcctgct tttatgtgta ctataaagta aaaggcgtac 2426821 gggcaaagcc atctttggca aaagaaatat gttcagcaaa atcaagcatg gccttagggt 2426881 cactagtcct gttctacggg cttaaccaaa tgatattatt ccattcagta ttaacgttag 2426941 taatcggcgg tatctttatc gtcataggag caggaagcgc ttgggcaggt tataaagcct 2427001 tcaggcatta caatcccctt cacgccaaag aagctgaaag agatcacgcg taaggggcgc 2427061 ctgaacgtcc cttagcttct ttccatcagc tgaaccatca gcatcgcttt agacacgata 2427121 tgaccttggc tgtgcacttc cacttccatt ttcccaaact ttctgccggc ctccaagatg 2427181 cgaggtttga cttcgatgac tgattccatc tgcacaggct tcaaaaagaa gatggtgatg 2427241 ctctctatga cgagttcgcc gcgttttttc gagcgcaaaa atcggtttgc cgcttgcgtc 2427301 aaaatggtcg taaatacgcc ataagaaatg gttccaagct gatttgtcat ttgcggcgtg 2427361 acttcatact cgtaaaccgt ttgatcttct ttatcatcac cctcatcttt aaaccccctt 2427421 gaaacgatat catcaagctt ctccccgacc tgcggctgct tttgaatcat ttgaagagct 2427481 ttcaatacgt cttggcggct gatcatgccg atgagttttt ggtggccgtc agtgacggga 2427541 agcacttcga tcccttccca taccatcatt tgcgcagctg aagcgacaga tgttttccca 2427601 ataaccgtga cgggattttt ggtcatgact ttttctatag atgcatttcg gtcatggcca 2427661 gcaatatctt ttgatgtcag aatgccatgg attttcattt gatcgtcgac aaccgggaag 2427721 cggccgtgcc ccgtttcaaa atttttctca taccattttt caagtttatc cttaggcgaa 2427781 agatataccg tgcggtcagc aggtgttagg atgtcctcca ccaaaacaat ttcttttttg 2427841 atcagctggt catatattgc ccggttaatc atcgcggcaa ctgtaaaggt gtcatagctc 2427901 gtggataaaa tcggcagttc aagctcatct gccagctgca caatgctgtc atccgtgtta 2427961 aagcccccgg tcaccaatac ggccgcgccc gcttcaagcg cctgcctgtg tgcattgatt 2428021 ctgtttccga caatcaaaag attccccgct gcggtgtaac gcatcatcgc gtcaagctcc 2428081 atcgcgccga tgacgaattt attcaatgtc ttatggagcc ctgccctgcc tccgagcact 2428141 tgtccgtcta taacatttac aacctctgca taggtaagct tttcaatgtt ctcttttttc 2428201 ttttgttcaa ttctgattgt gcccacacgt tcaatcgtgc tgacaaaccc tttattctct 2428261 gcttccttga tcgctctgta cgcggttcct tcgcttactt tcatttcctt tgcaattctt 2428321 cggacagaaa ttttttcacc gacaggcagt gaatcgatat acgttaaaat ttgttcatgc 2428381 ttcgttgcca agcctttcac ctctaaggac agtcttcttg tttttattat aaggtttcaa 2428441 aggatttata cgcaatgagg ctggaaaata aaaaagaagc ccgaccggct tcttacagcg 2428501 ttgatttcgt tccagtcaaa cgcaaggacc acgtgattcc ttttacatcg taaagcggaa 2428561 aaacctttat ttttctttta aatggacatc aaccgctgtc ttaacaatat ttcgattccc 2428621 tattttagat aaaacaaata aaactgcgga tagccatatc gcccctatgg ccgtatagat 2428681 caatggatga acagctgtgt ttgcgatcca ttcatttatt aatgttctgg catttaccag 2428741 aataataaat cctcctacaa gcacacccat caattgcgga tgaaacttct gcaccagcca 2428801 tgctgcgata ggggcagcga taattccgcc ggccattagt gaaaacaccc ataaccaatt 2428861 gacgtcctcc catcctaatg aaataagaaa accggcggtt gcagatacgg cgatggcaaa 2428921 ttcacttgtg tctacagtcc cgacaacttt cctcgggctc aagcctttgc gggataataa 2428981 aatcggagtg gtcaccggtc cccagccgcc tccgcctgtg gcatctgcaa aaccagcgat 2429041 cactcccaat gggatggatt gttttcggtt taacggcaca tgcttcttct caagagccgg 2429101 cttatattga aataaaaacc tgatcaatac atatccgccc agaaggagca aaaacaaaga 2429161 aatatagggt ttcgccacat ctccaggtaa ttggctgagg aatgccgcgc ctaaaaaagc 2429221 gcctatagag ccgggaatga caagctgata aacggtttgt ttgtcaacat tgccaaattt 2429281 aatatgcgac actcccgatg cggcagtcgt tacgacttcc gctaaatgga cagaagccga 2429341 agccacagca ggtgtgatgc caaacgccaa taacaaagaa gttgaggtaa ccccataagc 2429401 catacctaac gaaccgtcta ttaactgcga caataaacca ataaatgcaa aaacgattaa 2429461 tttcttcatc agaacacccc atctatatca atcagatatt tttgactctt cattcgaatc 2429521 taacaatctc ttggcgcttt catataaaaa ataagaggct ttgataattg cagtttcatc 2429581 tattgtaaat gcagggtggt gccaatcatg atcaccgtct gttccaaaaa acgcaaagga 2429641 tcccggaata tgctcaagat aataagcaaa atcttccccc gcggttgatg gggcgggatc 2429701 aatgacttga agtttcgctt tatgtgcagc gtctcgcacc agccccgtaa ttgcctcatc 2429761 attacaaagc ggcggcggtc cggaatgcca cttcacattt gcctttaacg agaaagcggc 2429821 agaaatctgc tctgtgactg caaaaaaacg ctgtttcact tgattacgaa cctctgaatc 2429881 aaatgtacga acagtgccct caatgaccac tgtatccgga atgacattcc aagtgctgcc 2429941 gccgttgatt ttccctacgg ttaaaatcgc gctttgcagc gggtttacat ttctgcttac 2430001 aatcgtttgc agggcgacaa taagctgaga ggcgccgata attggatcaa aaccattatg 2430061 cggcaatgct gcatgagcac ctttcccttc tatctctact ttaaatcggt caacagcagc 2430121 cataagcggg cctgttttta accctacagt cccaaccgcg atatccggtt tattgtgaag 2430181 gccaataacc gcatcaatgc catccagttg gccgtcctct atcacttttg tagcgcctgc 2430241 acccgcttcc tctgctggct gaaataataa acgaatcttt cctttcagac tgtcttgatt 2430301 ttccttcaat aaaaaggccg caccaagaag cgctgccgta tgaaaatcat gaccgcacgc 2430361 atgcatgatc cctttatgtt tagacgcata aggcaatcct gttttttctt caattggcaa 2430421 ggcgtcaata tcagccctca aagcaatcgc cggaccttct gactcccctg ctatgtctgc 2430481 gaacacaccc gtttttagag cagtagggcg aatctgtatc cccttttctt taaggcattt 2430541 ttttataaaa gcagttgttt caaattcttc ttttgacagt tcaggatatt ggtgcaggtg 2430601 ccggcgaatg ccgatgagct gcttttctag cgttgagaga tttacgggat tagactcctc 2430661 tttcaacgtc aggatgtcat ttcctgtagt ctgatatgga taggagcctt ctatatttct 2430721 ccaataatcc aaagacatat gttccgctcc tttccctatc ccaatatatt ttcttcagac 2430781 tcttcaacat aagatgaaat aaatcggttc aatttatcag caagaccgcc cgccccaaat 2430841 cttatatact tgctggaaac tttcggatta tcttctttca aaaagcttaa aaaagataaa 2430901 atataaatgc gcctgtaagc tacttgtgta attccgtact caaaaaacca gttatcaatg 2430961 acattgtata cgcctcggtt gacgccatat aggttattac atttcttgta aaagcagaga 2431021 tccggaagat ttaactcctg atgggaaaga aggctttctt ttttgtttgg tgccataatc 2431081 ccaatcagct caaagcgttt tgcaacgcac gaaatatcct ttttaatttg ctttgttaaa 2431141 gactccaaag aatcaaacct tctttcttct ctaattttaa agagaatgct gcattcgatt 2431201 ttttctccat aaatgtctct atgaaagtca aacaaaaaaa tctccaatgt cttttcaagg 2431261 ttagagccca ccgtcggttt cacaccgata ttcataaccc ctaaatgaaa ttgatgattg 2431321 actgtcgcca gaaccccata aactccatta cgcagcccat gtatttttgc atctacattt 2431381 gccgtgggga atccaagctt tctgcctaat tgttttcctt tcacaaccgt accggcaatg 2431441 atcgtcaaaa aagtcagcct cctctctcag cttccgcatt cgatcagacg aaacctaatg 2431501 atgtgatgaa tgtaaaacgg attgatgctg cggaatgcca agaccgagat tttcccgcaa 2431561 tgtcccgccg cgataatctt gacgataaag ccctctttct tgaagaatcg gaatcacctt 2431621 ttctacaaaa gcatcaagtg ttcccggtat atccgaccca acgataaacc catccgccgc 2431681 ctcagcgttg aaccaagttt caattaagga tgcgacacgc tctggtgttc cgatgaatag 2431741 agtccgtgga aaagccattt cctgtgctac ctcccgcaat gtcagatttc tggcttttgc 2431801 ttctctctta atccggtctg ttgtgctttg aaacgcattc tttcccacat cgccaatatc 2431861 gggaaatggc tcatccaacg ggtaaacact cagatcataa tcatcaaaaa aacgggccaa 2431921 ataagtaaca gcattttcaa tcggtatcaa ttctgcaaat tcacgatact tcttttccgc 2431981 ctcttcttcc gtatctgcca caatcgggct gatccctgga aaaatccgca cacttgaagg 2432041 atcacgccct tcatcagcag ctcggctttt cacatccgca taaaacgctt ttgtctcttc 2432101 taatgaattg gaatgggtaa aaatcgcatc cgcattttta gcagcaaact gccggcctgt 2432161 ttctgatgaa cccgcttgaa acactacagg ctctccctgc ttagagcgcc cgatattcaa 2432221 gggcccctct acttgaaaat actttccttt atgattcagg cgatgaagct tcgcctgatc 2432281 gaaaaactgc cctgttttct tattgtgtat aaatgcgtca tgctcccagg aattccacag 2432341 cccgcgcaca acatccaaat gctcttgtgc gatctcgtaa cgttcagtgt gttctggcaa 2432401 attagactta ctatggttgc gcgccgctcc ttcctgcggc gaagtaacca gattccagcc 2432461 ggccctgccc ccgctgatat ggtccagcga catcaattgt ctggagatag tgaatggctc 2432521 agtaaaagat gtagagaacg tccctactaa accaatattt ttggtaaccg atgccagcgc 2432581 agataaaatg gtgatcggtt caaaacggtt taaaaaatga ggaatcgatt tttcagaaat 2432641 aaataagccg tctgcaatga aaataaaact aaacaaacct ttttcagctg tttgcgcctt 2432701 tttcatgtaa aattcaatat tcgtgctggc cgagggatca acatcgggat gacgccagcc 2432761 gtcagttgtt cccccgacac cgtgaatcat ggctccaaac tgaataaaat ctgcacgtgt 2432821 catctttttg cctcctttat ctgtgcatga ttagcaagtg caagatcaag gtgttcaatg 2432881 ccgatttcag ttatcccttg atactgattg ccgcgcccga tttcgaccac aggcacatgg 2432941 cgcaccccat atttcacctg taaaatatcc cgaagctttt ctttctctga aacatcgata 2433001 ttttggaacg ggaacccttt ttcattcaaa taattcttga cttcctcaca atacgaacag 2433061 ccttttttac tccaaaccac aatgttcaca acatcactca ttcttctgtc cctccttaac 2433121 gttttgcagc taaaactgca tcgctcagca gctgataaga cagctgtttt tctacagcat 2433181 ttttgatcgg tgtaaaaata acaaaatcat tgattttgta tgtgcctgat aaacgtgtta 2433241 attcttctgc cacttcttcc tttgttccgg caataatccc ggttttttgc acgatgatgt 2433301 catagggctc tgtgacgttt tccagatagg cctcagcctg ttcgcgggaa ccgacgttga 2433361 ccttacgccc gtctttcaaa accactttta tcgattcacg cgacacaata tgtttttccg 2433421 cttcttcttt tgtatgtgcc gcaaaaacag cgggggcaag atgaaattca gcctcagatc 2433481 ctggcgggag atgcgcgtca aatgctcggc gggcttcctt cagcacttcc tcttcaccgt 2433541 taataaagta agcaaagaca aaagagattc ccagttttgc agcagaaatg gcactctctg 2433601 tgcttcctcc caatagaaaa atacccggct tccgatcaac ctgcggccta ggacgcaatg 2433661 cggcatagcg gtgggtatca ggaaaatcat cccgaacgaa atgagtaagc tcctccagtt 2433721 tttcatcaaa ctgacgcacc ggttttttat attcggcctg cagcgcgtct gtggacagct 2433781 gaaacccgcc gggcgctttg cccactccaa gatctatacg gccgggagct aacgctgata 2433841 gaagatggaa ttgctccgct actttataag agctgtaatg ctgcagcatc actccgcctg 2433901 atgctaaacg aatttttctt gtgcttgcag caagatagcc taaaagaacc tcgggtgcag 2433961 accctgcaat ctcatcattg ttgtgatgtt cggccaccca aaatcggtga tatccacatt 2434021 cttcagccat ttgtgccaat ttcactgtat gctgtaatgt atcagctgct gtctcccctt 2434081 caccaatcaa gctttggtct aaaatactta agcggatcat atcaccggct cctttatgtg 2434141 ttcttttggt tcaaataaat attccggcga aacacggcgg agaaactgcc tcgttctgtc 2434201 ttttttggta tggcggaaga cttcctccgg ggttccttgt tcaacaatga ctccttcatc 2434261 cataaaaaca acttgatcag agacccttct tgcaaactcc atttcatgtg taacaacaat 2434321 catggtggct ccggttttca cgatttccag cattacctca agcacttcac cgaccagctc 2434381 cgggtcaagc gctgccgtcg gctcatcgaa cagcagcaca tcaggatgaa tggcaagcgc 2434441 ccttgctatc cctaccctct gcttttgtcc tcccgataac tgactcggat aagcgttcaa 2434501 tttatcttga agcccgacct ttctcagttc attttccgct acggcatacg cgtcttgttt 2434561 tctcattttc cgggcaatcg tcaagccctc catgacattt tcaatcaccg ttttgtgagc 2434621 aaacaggtgg tattgctgaa ataccattgc cgtctgtttt ctgagccagt gaacctcttt 2434681 tttggacgga aagcggcaat taatcacttt gtcatgtata gaaatgatcc cttcgtctgg 2434741 acgttctaat aaattcaggc accgtaaaaa ggtggttttc cctgatccgc tcggcccgat 2434801 aatcgtcaca acttctccct tgcgtaccgt gagatttatc ccttttaata catggtggat 2434861 gccaaactgt ttatggatat ttttaatctc aatcataaag tgcctccttg aaatctggct 2434921 gcctttctct ctaatactcc atttgcggat tctaggatta gagtcagcac ccaatagata 2434981 atcgctgctc cgataaacgc ttctaaaaat gcataattat cagaagcaac gatagtcgcc 2435041 gtccctgtaa tctctgggac agccactata gccgcgatag aggtggtatg caaaaagccg 2435101 atacccaaat ttgtgaagtt tgggatggaa accttcagcg cctgcggcaa tattacacgc 2435161 cgaaaggttt ggctgtatgt caagccgatt gaataagccg cttcgacctg tccggtatcc 2435221 atcgccagaa tgcccgaccg gatgatttct gtgagataag ctccggcagt taaagacaag 2435281 gccatgatga caaacatgga gaccggtatc tcattagcgg accagccgag atgaaaaaaa 2435341 ctgctgactt gatctgcaac aggcggtatc cctaaataaa tcaacataat gtgaagaatt 2435401 gcaggtgtac ttcgaaagaa agacacataa aaccttgagc aagccaccaa gcccttaatt 2435461 ctaaaaattc taacaattat atttccaaga gccacgagaa atccaaacac aatcggcaaa 2435521 acagccatca tcaatgtcag aggaatggtc tttaccattt ctttcatggc ggaaacgata 2435581 aatggaaagt caaattgcaa tcttctcccc cctcatccga agaaatatat caatgtatgt 2435641 tcatgtcaaa aacagtaaca atccttgttt gattcttctt gattcgtttt tctgccactc 2435701 gaaagaacca ttcgaataaa accgctacag cataataaac aatcgatagc gcaatgtaaa 2435761 cttcaagaga atggttgctt gaggtaatca gtgtttggcc ccttccggac atatccataa 2435821 cacctattga aaaggctaga gacgtatctt ttaaagaact gatcaccatg tttcccatat 2435881 tcggaaacgc ctggacaagt gcctggggca gaacgattcg cctgaaggcc tgactaccgc 2435941 ttaagccaat actgtacgcc gcttccgttt ggcctttatc tacactgccc acccccgctc 2436001 gaatgatttc tgcggctgcc gctgcattgc ttaacgcgta ggttgcgaca gcagcataaa 2436061 acgggtccat ttttgatgta tcaatcccga taagccccgt aagcgccggg atcccgtaaa 2436121 acacgatgaa aagctgcacc atgataggcg ttcccctgaa aaacgagata tacacttttg 2436181 ccaattgatt tacaattgga atattataga tgcggggcag tgccagaaag agtcctaata 2436241 caaaaccgaa aagcaaggac agtgttaaaa tgtataatgt aaccggtaaa taagcggtta 2436301 acgtcggcac aaaatctcca atcatgttca tatcaaacgc tttttccatc actgctccct 2436361 ctctttttac ctaatactgc tctttggaat agtcgtcacc aagccatttc aaactgagcc 2436421 ttttcaacgt tccgtcatca atgatttcct gtaaggcttt atcaatatcg tcacttaacg 2436481 tttgttcatt tttgttaaac ataaaataca ctttggcatt tgaaagcaca ttaccgacgg 2436541 ttttttcttt aatagtgctc gtcttgtttt gaaagtctac tgcaaaaggc gttgagatcg 2436601 ttgcgtccgc acgccccgat ttcagctgat tcgcagtctc atttgcgcct tggccctcat 2436661 aggcaatctc aaacggccgt ccattatcct cattccattt tttcagtaca agcgctccgt 2436721 tggaggttgc actcgtaatc acccgttttc cttttaagtc ttcaattcca cggatcgtat 2436781 cgttattttg aagcacagta atttttaaag gaaaatggtt gtaagcaacc ttgttaaaca 2436841 gaaatttttt ctcacgctct ttgcttttct ccatttgatg tgccacgata tcgactttat 2436901 gctgtccgag gctgacaagc aggttggaaa attccatcgt tttaaatgtg aatttataat 2436961 gtggcaggcg cttatcaagc tctttgatca gttcgacatc ataaccggtt aaatcgcctt 2437021 tttcatcgat aaagcaaata ttcggaaatt gggttccagt tccgaccgtg atcgtctgta 2437081 ccttcttttg cccggctccc gtcgtttgac tgcctgcacc gcaagctgac agaactgtta 2437141 taagcgaaaa taatattgcc atgaatgctg ttttcgtttt catctcatcg ccccatttat 2437201 ttttcaaaac ttgattttga ataatctgcc ccgagccatt ttcggcttag tttttttagc 2437261 gttccgtttt tctccagctt tttaatcgct tgatccgtgt catccgccaa ggtttggctg 2437321 cctttattaa acataaagta cacctcggta tctaataaca cgtcaccgac tgtcttttgg 2437381 cggaaggcgt gcgttttatt ctgaaaatcg acggcaaacg gtgtagctat cgttgcatct 2437441 gcgcgcccgg tttcaatttg attggcggta tcattgcttc cctgtcccgc atatttcaaa 2437501 tgaattgggc tgccgtgcgt tttgttgtac tttgtaatat aatctgccgc atttgacgtg 2437561 gcgccaacta tgactgtttt tccgtgtaag tcttttaatg tatgaatctt gtgattatcc 2437621 tctttcaccg tgatgtacat cggcgagtag ttatatggga ctttatgata caaaaaacgc 2437681 ttttctcgtt ctttattttt ggccatattg tgcgcaatca catcaatttt tttatttccg 2437741 agactcgtca gcaaatttga gaaatccatc gttttaaatt caaatgtata ttgaggcaac 2437801 tccttatcga tggctttcat cacttcaatg tcatacccgg tcaattcacc tttttcattt 2437861 aaaaacgcaa tattcggaaa atctgttcca gtgccgacta tgaccgtttg agcctgacga 2437921 tctgttttgt tatttgtttg cgaacatccc ccgccaagta atgcaaacac tgacagcagc 2437981 aaaaccaatc ctttacgctt attcataggc tgcctcacat catgcccagc tgggcgcacc 2438041 taaaagcgtt gggttaaatc gttccggaat cagaaccttg tgcatcatca cacctatgtc 2438101 cccgtctttt tcctgctcaa aatacacttc ataccctctc cttctgtaca tgtcagcaag 2438161 ccaaggatgc ttgcgcgccg atgtgccgag tgtcagcgca ggagccttca gcatatctcg 2438221 aagcactttt tcttcaacat acgtaagcag cttacttccg gcgccttgcc ctttatattc 2438281 cggcagtgtc gcaaaccacc acacaaatgg atattttgaa ggaggcgtct cactctccca 2438341 cgggaacctg attgtaatcg ttgaaatcag cttcccatcc cgctccagca caatcgctga 2438401 atgatgttca atattttctg ataccatttg gatatcagct ctcgtggatg gccaatcaat 2438461 atccagctgc cgaatgggct gaaatgcgct gttaaccagt ttcaacagct ccgatgcatc 2438521 ttcaacagtt gccagtcgaa aaatatcatc actcattttt gtcactcctc ttcacaaaat 2438581 atataattcc tatttgttta ctaagctttt attgtttata ctataaagca tactctgatc 2438641 tttgactaat caaaaaaagt aaaccttcac ttcagtaatt ttaatgatga aaaacaggag 2438701 ggagcacatt ggagttacgc tcaatcaaaa cgtttcatac gattgtaaaa tttggaagct 2438761 tctataaagc tgcagaaata ctcaactact cgcagccgac gatatcgatg cgtatgaagc 2438821 aattggagca ggatttaggc gtactgctgt ttgaaagagg aaaaagcctg cagttgacaa 2438881 aagcagggaa gcttttttat gaacgaacag gagatctttt gatgcaatac gaggcgctta 2438941 aacacaacct ctccgactta aaggaagaag aggcaggcat tatcaacata ggggtttcag 2439001 agccaaccgc cagtctgata ttccccgaga ttttaaagga tttcttaatg gattacccaa 2439061 agataacggt taatatcaag gttgatgacg ccaatacctg cagtcaaaag ctcttagacg 2439121 ggacgattga ttttgcagtc tgcggcgagc cggagctgat tcttgaaaat tactaccatc 2439181 cattttttta tgacacatta aatgtgattg tatctgatca acatccgctc gctgagaaga 2439241 aggctgtcca tttgtctgat ttagcagaag agcgcttcat atttacgccc gccaattgcc 2439301 ccattcgctt acaaattgaa cagcatttac atagagaact cgggaatcgc tacaaaaaaa 2439361 tggagctcac aagcagcatg tcacatgaat attacgtacg tgaaaacatc ggaatttcaa 2439421 tctttaccag caccgcacat tctaaaccgt tcaacggcac taaagtcatt ccaattctga 2439481 acctggatat caccccgccc atagggctgt tgacaaatca aaaagaagtt cattttgacc 2439541 gcgccacgaa ggacttgatc gcccggataa ccaaacgttt tcagcagcgc agcaaagaat 2439601 tggaaggaac ctctgataag accattacag gataactgaa aaaataaaaa ccacctcctg 2439661 attcatcagg agatggtttc acggtttaaa gctcgatcgt ctcaccgacc gacatgactt 2439721 tgccgactcc gcccggcagg ctgtcagcga atgcttctgg gtcttgttcg atgaccggga 2439781 atgtattgta atgcaccggc acgacctgtt ttgcgcgcag ccattcagca gcaagcttgg 2439841 cgtcttcagg ccccattgta aagttatcgc caatcggaag gaaagcaagg tcgatatgat 2439901 tcaattcgcc aatgagtttc atatcagaga aaagtgccgt atcgcccgcg tggaaaatcg 2439961 ttttatcttc tacagtcagc aaaataccgg caggcatgcc tgtgtaagtg atcgttttgt 2440021 tttcttcatc tgtgatggct gatccatgaa aggcctgtgt gagcttcact tttccaaaat 2440081 cgaactggcg ggagccgcca atatgcattg gatgaacatt caagcctttc cagcctaagt 2440141 acacagcgag ctcgttcggg gctataacca gcgcgttatt ttgcttggcg atttgttcag 2440201 tatcaccgac atggtcattg tggccgtgcg ttagtaagat gacatccgct tttacatcct 2440261 ccggctttat atccgttaat gaattccctg ttaaaaacgg atcaaaaata atatgatggt 2440321 ccttcgtttc cactgtgatt acagaatgtc cgtgatatgt cactttcatt tctttcacct 2440381 cgtcacatga ttttgttttt tttattttcc ctttttaaaa agctgaaaaa cttatgttgt 2440441 ttgattcttg ttaatgacat tgaggcctcc ggtggcttca atgacagtcc ctgtcacaag 2440501 gtctgagttc tcctcacaca agaaagcgat aatcctggca atatcctcgc ctgtaccgga 2440561 tcttcctatc ggcgtttttt ctttgccgat tcgcattctg gcttcctcta tcgatgcttc 2440621 tttcatgtcg ccgacaatgt ctcctgggca aaccatgttg gcggttatgc cgaattcggc 2440681 ttcttcaatg gcaattgtct tcgtcaaaga agccaagccc actttcgcag cgccaaatgc 2440741 cgatcggtga agccagccgg gcgcgtgagc cgcaccttgg aatccgtacg taataatgcg 2440801 tccaaattgc tgttttctca taataggaat aaccgctttg aataaatgaa agacggcgct 2440861 taaatttcct tccagcatgc cataccattc atcatcagta taatcggcta actttttacg 2440921 ttcaaatatg tatggtccag cgttgttaat caaaaagtcg atccttccga agcggtttaa 2440981 ggcagcctct gcaatacgca gcagatcttc ttttttggtg acatcacctt ttacaaattg 2441041 cagccggtca agacaatcgg gacaggcttc cttcaggcgg ctgactgcct cctcatcctg 2441101 tctgtaattg actgttactg aatacccctt tgcaagcaac gtttcagtca ctttgcggcc 2441161 taaacccttc gaaccggcag taattaaagc atgtcgcaca tgaatacctc ccaaagcaac 2441221 gtcgccgctt tcaataaagt gtttcttctt ctactttact ataaaaggct tgcaatatca 2441281 ctttttacac tttggcatac aaaaaaagct gcctgtacag acagcttatt ctgcaggaga 2441341 tgaagactcc tgatcaggca tatcgacata accgctttga tatgcttctg aaatgagcct 2441401 tgttgtctcc tggctttctt gttcatcata aatatagcgt tccggttctt ttttcatcat 2441461 tctgcctccc atcattatag aggtaggttg gctataatga cgggatttta tgaaggaaat 2441521 tttaacaaac tcctgctgcc acgcaagctt tcgctttttc aagcgcctgt tccacctgtt 2441581 tgaatccggt gcccccggcg ctcattcttt tttcaactgc gtagtaaggg tctaacacag 2441641 tgtaaatatc ttcttcaaat agtgtgctcg cctgctgaaa ctcgccaaac ggcatatcgc 2441701 ttaaatagat ccctctttcg atgcatgtgt acacaagttt cccgaccact tcatgcgctt 2441761 ctctgaacgg cattcctttt ttagctaaat aatcggccag ttccgtcgcg tttgaaaagt 2441821 cttgttttgt tgcttgcttc atgacgtctt tgtttacagt cattgtttgg atcatgcctg 2441881 tgaagatttg caggctgccc tccaccgttt tcaccgtgtc aaacatgccc tctttgtctt 2441941 cctgcagatc tttgttgtaa gcgagcggaa gtcctttcat gatcgtaaac agccccatca 2442001 tatcgccgta tacgcgtcct gttttgccgc ggatcagctc cgccatatca gggtttttct 2442061 tttgcggcat catgctgctt cctgttgcgt acgtatcgtc aagctcgatg aatttaaact 2442121 cctgcgagca ccataaaatg atttcttcag agaaacggga taggtgcatc atcagcatac 2442181 tgctgttgct taaaaactcc aaaatgaagt ctctgtcgct gacgccgtcc aagctgtttt 2442241 cataaatggc atcaaagccg agcagttccg ctgaataatc acggtcaatt gggaaggttg 2442301 ttcccgcgag cgccccgcag ccgagcggag atttgttaat ccgcttcatt gaatcctgaa 2442361 aacgctcctt gtcgcgctca agcatccaga aatacgcaag cagatggtga gcgaatgaaa 2442421 tcggctgggc gcgctgcaaa tgtgtgtagc ccggcagaat cgtttcaacg ttcgcttccg 2442481 ccttttcaat cagcgcactt tggaatgcct caatcagctc gatgatgtgg ccgacatgat 2442541 tcttcaagta taaatgcatg tcagtcgcca cctggtcatt ccggcttctg ccggtatgca 2442601 gcttgccgcc aagaggaccg atttcgtcaa tgagcatttt ctcaatgttc aaatgaatat 2442661 cctcataatc gactgagaat tccaatgctc cctcctctgc tttttgcaaa agggtattca 2442721 ggccctctcg gattttcaac tcttcttctg ctgtcagaat accgcatttt ttcagcatgg 2442781 cagcatgtgc gagagaccct gtaatgtctt cagcaactaa attttggtca aatgatatgg 2442841 acgcgccgaa ctcgtcgacc catttttccg gtgttttttg aaatcggcct ccccaaagct 2442901 tcttcatgct ttaatctgct ccttcttttt cacgatgctg ttcacttttg tcggaagtcc 2442961 ccaaagctcg ataaatccga ttgctgcatg gtgatcaaat gcatcgtctt ttgtatatgt 2443021 tgcaagtttt tcatcatata gagagtattc cgatttacgt ccttctacaa ttgcatggcc 2443081 tttaaacagc ttcacgcgga caatgcctgt gacatgcttt tgcgtttctt ttaagaaagc 2443141 gtgcagcgcg tcttttaacg gtgagaacca taagccgttg taaatgattt ctgacatttt 2443201 ttgctcgatg atcggtttaa agtgggctac ctctttcacc agtgtcaaat cttctaattc 2443261 tttatgcgct ttgatcagtg tcatcgcacc agggcattcg tatacttccc gggatttaat 2443321 gccgacgagg cggttttcca cgtggtcgat acgtccgaca ccgtgcgcgc ccgccatttc 2443381 attcagcttc aagatcagct cagaaagcga gtaggaaaca ccgtcaatgg agacaggcac 2443441 gccctgttca aatgcaattt caatcacttc cggcgtgtcc ggcgtttttt ccagcggagc 2443501 tgttaaatcg tatgcacctt ctggcggcgc cgcccatgga tcttctaaaa tgccgcactc 2443561 attggcgcgt ccccagaggt tttggtcgat agaatacggg ctgtcaagat tgatcggaat 2443621 cggaatgccg cggctagccg catattcaat ttcttcttca cgtgaccact gccattcgcg 2443681 aaccggcgcg atgacttcta ggtcagggtt taatgattta atggagactt cgaaacgaac 2443741 ctggtcattt cctttccctg tgcatccgtg ggcaatcgcc tgtgcatctt ctttttccgc 2443801 aatttcaacc agttttttcg cgatcagcgg tcgagataat gccgaaacaa gcgggtattt 2443861 tccttcatac attgtgtggg cctgcaaaga gataagcgcg taatcctgtg caaattcttc 2443921 ttttgcatcg atcacgtagg agtttgtcgc gccgacttca agcgctttct gctgaacaaa 2443981 tgccaaatct ttgccctcac cgacatccag gcagcaggcg attacattat atccttgctc 2444041 ctgaagccat tttattgcga cggaagtatc aagacctcct gagtatgcta atacgacttt 2444101 tttctgttct gacatgataa aaatcccctc tcaaccgtgt ttctattttg tataaaaata 2444161 aattatattt aataaaaata cattttgtat gtatacactt taacaagtac gtttcgtttt 2444221 ttcaagcctt ttataaaaaa aacttcacct aaatttcagg tgaagtttca tagtatttat 2444281 tcatttactt gtcttttctg atttctctga ccacatgcgc aagttcggga ataatcagct 2444341 tattcattgc cagctttact gcgccgcttg agcctggcgt tgagaaaaca gcggtatgct 2444401 gaatgacgcc ggcagttgct ctcgacatga ttgcggcaga gccgatatcc tctgtataac 2444461 tcagcatcct gaatatttct ccaaagccgg gcagttcttt cgaaaacagc ggcgttatgg 2444521 cttcaattgt gacatcccga tctgctatgc ctgtccctcc gtttaagagt accgcgtctg 2444581 tctgttcatc catgcagccc gcaagcactg accgttgcaa agcatccttt tcgtctttta 2444641 caatttcata tgcggcaata tgatgaccgg cttcttctaa aaatgagatc atcagcttgc 2444701 cgcttttatc ggtttcatct gtcctcgtgt cactgacagt aatcactttg caccgaacga 2444761 tatcgggagc ttcttgttta tgctcttgaa cgctcattgg cccacctctt ttatgttttc 2444821 tgtctgtcac tatcatgcat caacaaaaaa gcacattcaa gagaatgtgc tttcatgcga 2444881 tttattttgc taaacgaaca acgtcgcgcg caatcatgac ttcttcatca gtcgggatga 2444941 tcatgacttt tactggagaa tgcggatagc tgatgaaagc ttcctcgccg cgcacgttat 2445001 taagcgcagg gtcccagtat acgcccatga attctaaacc gcgaagaacg cgttctctga 2445061 cttccacact gttttcaccg ataccggcag taaagatgat cgcatctaca ccgctcattc 2445121 ttgcagcgta agaaccgatg tatttgtgga ttctgcttgc gaatacttca agagccgttt 2445181 ccgcgcgctc atttccttct ttcgtagctt caacgatgtc acgaagatcg cttgagaaac 2445241 cggaaatgcc gagcagtccg ctttttttgt ttaatgtatt cagtacttcg tcagccgttt 2445301 ggcctgtttt ctccatgatg tatgggatca gggcagggtc gatgtttcca gagcgtgtgc 2445361 ccattgctac accggcaagc ggcgtaaagc ccatggatgt gtcaatagat tttccgcctt 2445421 caacagcggc aatacttgct ccgtttccaa ggtggcagga aatcaggcgc aagtctttta 2445481 acggacggcc gagaagctct gccgcacgct cagttacata tttatgtgaa gtgccgtgga 2445541 agccgtattt acggatgccg aatttttcat agtattcata cggcaagctg taaaggtaag 2445601 actgctcagg cattgtttgg tggaatgctg tatcaaatac agctaccgca ggaacatttg 2445661 gaagcacttc tttgaacgct ttaattccaa cgatatttgc cggattgtga agcggtgcca 2445721 attcagaaat atcttcgatt tccttaatgg tttcatccgt taataaaaca gaatcgctga 2445781 atttttctcc gccgtgaacg acacgatggc caattccgtc aatttcattc aagtctttaa 2445841 taatgccgaa ttccgttaac ttattcagca gcattttaac agctaccgca tgatctggaa 2445901 tatcagttac ttctgtattt ttttcgccgt tcacagaaat tgtgaatacg ctgtcggcga 2445961 taccgattcg ttcaactaaa cccttcgtta aaacggtttc tgaaggcatt tcgaaaagct 2446021 gaaatttcaa agacgagctt cctgcgttaa ttgcaataat tttggacatg attgacgctc 2446081 ctttatactc tgtatcaaca acttcgtttt tcgtactttt ttcccggtga atatcaacat 2446141 cttctccgaa aaatatctga cttttccatt taaacattgt catgtcggct tttcaagtca 2446201 acttgcgtat tgataacgct tacaataaga agtcgttatt ttcagacaca ttcactatag 2446261 gttttgtatt gatgaacgct tacaatttgc ggtttttccc tctgtatttt gtgtttcaaa 2446321 gctggattca attcgtcaag tccggtcttc aaaagcataa ataaaagcag cttaggcatc 2446381 gacctcatac ggctgtctaa gctgctttta aaacacttac ttttcttttt taaaccattc 2446441 atcaaattga gccatcatat caagcatcgc cttttgattg gagaaagacg gaagattcgc 2446501 aagcagaatt tgccccggcg ctttcgtatt ctctccttgt ttctgaagca caaggatgct 2446561 tttggcatga gcttcgtctt taaaaataga ttttggcagc tgcaacagtg cgttgatatg 2446621 aaccttatct ttgaaaaact gtttcagctt gccgctttgg gagctctcaa acaaatgatt 2446681 cggaatcata aaaaataagt agccgcccgg tttggtatgc ttgacgctct gttcaataaa 2446741 cagatgatga gcgaaggaat ggccttcgtc agctttgagc tcaaacgctt ctgctccttc 2446801 gtcattcgga taatagccga ctggcagatc acaaatgacc gtgtcaactg gatcgataaa 2446861 caacggctca aggctgtcct ggtggaaaag ctcaagctct tttttcagaa ggttcgcttg 2446921 ggcataggcg atcttcaaga gcacatcatc aatttcaatg ccaaagctgt ttgccgtttt 2446981 ttcagacagc tggttcagca cggtaaacag aaggttccca gttcccaggg ctggatcaag 2447041 aatggtcagt tcctttttgt ccgccataaa tttattcacc aaatagctga tgaaaagccc 2447101 gatcgtatcc ggcgtcattt gtctgtttgg atgcgagata tctttcattc ctttaaggac 2447161 ggcaagctga aaagccttgc gtacccactc atgctcatac gtgccgaatt ccgctttttc 2447221 aagcagagcc tgaagttgtt tggttttctg atcagcaggc agtttcagct gatccgtttt 2447281 ttcaagaaaa tacatttctc ctgcttcggc cagcgcctct atatatgaaa tctgcaattc 2447341 attctttatc ataatcgcgg cttcgtttaa cagctcatac accgcaccta catggtcttt 2447401 ttgcatattg tgttcctcct tgccatgaaa aaagctccgg cggcagcctg gagctttttt 2447461 ccctgcttac tttactaatg ccttagcagc ctcaattggc ttttcatagt tcgggtggtt 2447521 tgttgcttcg cttacatatt cagcgtaaac gacttttccg ttctcatcaa ggacaaatac 2447581 ggaacgcgca agcagacgaa gttctttaat atacacaccg aacgcttcgc caaatgacat 2447641 atctctgtgg tcagacagtg tttccacttt gtcaattccg ttagcgccgc accagcgcgc 2447701 ttgcgcgaat ggaaggtctg cactgattgt gtagacgttg acatctccaa gctttgcagc 2447761 ttcttcgtta aaacggcgtg tttgtgcatc acaaacacct gtatcaattg aagggataac 2447821 agaaataatc gttacctttc ctttcatgtc agctaacgat ttttcttcaa ggctgttagt 2447881 cagcactgtg aaatcaggag cttgatctcc taccttcact tcttgtccga caagtgtaac 2447941 cggaccgcct ttgaatgtaa tttcagccat tataattcct cccttttgta tgtatgtctc 2448001 tatcatagta aagtttcctg caaactgcaa agtttatgcc aaaaaaaagt taactgcggc 2448061 cagcgcagtt aacctttttt taataattca tattgttcat ttggttttga ttttggcctt 2448121 ggctttggtt tttgttattt ttcttgaaca tttgctggat gcgctcgagt gtttgagggg 2448181 ctgcgtctaa aattttctct attaaatggg tattttcatc taaatgaagc attctgatgc 2448241 ctgtcgatcc gacaattaaa aacgcgatcg gcgtaatgga cacaccgccc ccgcttccgc 2448301 ctccgaaagg aagtttctgt tctcttgtct catcgtcttc cgatttcttt tcggccggct 2448361 ttccgccaaa ctcgcttccg cctgcggcga atccgaatcc aactttagaa acagttaaaa 2448421 tcacacttcc atcaggcgtt tccactggat ctccgatgat ggtgttaaca tcaatcattt 2448481 ccttcaagtt ttccattgcg gttttcatta aaccttggat gggatggtct gccatatacg 2448541 cttcctcctt aaactgatga atcattcttt gaagtcattc tagccgacgg attcttcttt 2448601 aatacggata gctcccgtcc gtatttgacg aatttgaaag ctgcaagcat agcatgtcca 2448661 aagcgaaaaa agaatataca ctgaaaatgg gtcttggaaa cagggacttg aaacgacggg 2448721 atcacctcat agacaggttt attcacaaag tccaggtggt cgtagagcat tgctgcgata 2448781 ccgcccttca cgccccatac agcaccggtt aacacacctg tcactgccgc gtcctgaatt 2448841 ccgattactg taacccattc tagttttgtg atatgtaaat gcgcgagaaa agacgcgctg 2448901 attttccgca gtctggtgac ctgatgcaaa agcatttcga ttttattaat gctttgctgc 2448961 acatcgtttt gtgtaatttt tttctttccg ctgctttttt tcattttgga ttcagttttt 2449021 tgtttgatat ccactgttcc gtcttctttg ttcaccttaa tcgccgggat tgtttttttg 2449081 atccttataa ggccaaacag cgccgtaatc ttcaaggtca atttgtcatt atcatcggca 2449141 tgaagatact ccagcgcgac atggattttc attctgagaa gcagtacgat ccctatgaga 2449201 ataagaatgg ctgtcagtac atacaccata ttcttcactt cctctaggag cattatcgcc 2449261 aattcctaaa aaaataaacc cggacggaag tccgggttat cggttatttg cggtataatt 2449321 tttcatgcac cacggtggta tccgcgatgt aatcatgaat cccttgtttt gtaggtgaaa 2449381 aggcaacaac gatatataaa atccaaatct tatcaatata ccgtccaacc acttcacgaa 2449441 aaatcactgt actccatgtc agcttgctat cttgcttcac agaaaccact ttgaggccga 2449501 acaccatttt accaagcgtc tgcctgaagt attttgtcat gagtgcgaaa taggcaagat 2449561 acacaataag cgttgtcaca ctgtaggccg agaaggtaaa catgccggat gttttcggca 2449621 gatccaatac ggtaaagagg ggagaaacga gcaaatggtt taatccccat atcacgagcc 2449681 aatcaagcag gaaagcccag aaacgaaccc aaaagccagc ataggcatgt gtcagcagct 2449741 ccgcttcttg cgggcctttg atgtcattgc gctctaactc ttcatatgtc gcgtccatta 2449801 ttgttccctc ctacttcgca tagagataca tcattctcgg cgaaccggat tgcgatagaa 2449861 tttctctcat attcaaaaaa tcaatttcac ttttaaacat tttgttcgcg cccatggaaa 2449921 acagtgagcc taatccgaag ctttcctcat aagaaatgac agaggcgttt ttcaaatcct 2449981 tgtgatcctt tttcatggcc gtaatggtat cgtcataaaa accaagctca tcaacgaggt 2450041 tcagtttttt cgcctgccgt ccgtcataca cgcggccgtc cgcaattttc tttacctctg 2450101 ctttcggcat gccgcgccct tttgaaatga catcaacaaa gccttcatac gaattatcaa 2450161 ccatcgattg catgatgttt ttttcttctt tcgtcatctc acgggaagga gacataatgt 2450221 ccttatgggc cccgctctta atcgtttcaa aagaaatgcc aagcttgtcg gcaagctttg 2450281 aataattgac gctttccata atgacgccga gtgacccggt cagggtttcc ggtgtcgcaa 2450341 aaatcttatc agccgctgtt gagatgtaat agcctcctga tgctgccatc gaacccattg 2450401 acacgtaaat cggttttttc gtttctttct tgatttcttc cagtttctta tgtatttcag 2450461 cactttcata cactccgcca cccggagaat tcaccttcag aacgatacct ttgaccgtct 2450521 tgtcatcttt tgcgcgctca aggtttttta agaacgttct gtggttatat ccgtctgcac 2450581 caagcagact gcttgagtcc ccattatcct gaatggtgcc gctgacctct aatacggcaa 2450641 ttttacttga gggactgccg ttttccagcg tcttctcctg cgattcatcc gtcagtgatg 2450701 tgagatccgt ttgagcgcct ttgacgcttt caaagaaact catagagatg ctgacgataa 2450761 tagacacgcc gaaaatcccc agagcaatca ctaatgcaat ccatcttttt gcattcattt 2450821 tttctcctcc tttttcctaa actctctcat tatacgattc aatatgaaaa atgtttcact 2450881 tcatgagaaa gctccggctt aacgggctgc cggcaaacgt ggtacactta tggccaaagg 2450941 tattttatca caaatactgg atggcagaaa aacttaaata tgacagcaaa ggggaaatgg 2451001 gatatgaccg atcaacgccg taatgtttat ttttttcaca aacaggatca ggaaacgaac 2451061 gaacaagccc gctcgttaac acaattagcg gaagagcatg gatttaccgt tgtgaaccag 2451121 cactcagacg ccaatattat cgctagcatt ggcggggacg gcacattttt gcaggcagtc 2451181 agaaagacga attttcgtga cgactgcttg tacgtcggca ttaccaaaaa ggggaaagct 2451241 catttatatt gcgactttca tagtgatgag cgagaaaaaa tggtcgatgc aatgacgttt 2451301 gaacaaattg aagtgagaaa atacccgctg attgaagtga cagtggatca agccagtcct 2451361 tttcactgct taaacgaggt atccatccgc tcaagcatca tcaaaacctt tgtgatggac 2451421 gtgctgattg acgatctgca ctttgaaacg tttagaggtg acggaatgat tatctcaacg 2451481 cctacaggga gcaccgccta taacaagtct gttgcaggag ctgttgttga tccattgctt 2451541 ccatgcatgc aggtatcaga gcttgcatcc cttaacaata atacctaccg gacactcggc 2451601 tcgccatttg tcctcagctc tgaccgaaag ctgacccttc gtgtggtgca ggacggcaac 2451661 gaacacccaa tcatcggctt ggacaatgaa gcactcagca cgagaaatgt gaaaacgatc 2451721 gaaatcaaac tgtctaataa gaaaatcaaa acagtcaaac taaaggacaa ttcattttgg 2451781 gaaaaagtga agcgtacttt tttatagaaa ataaaaggac aggctgctgc ctgtcctttt 2451841 atgatttctc atatacaatc tggccgttaa tcacggtttt tttaatctct aaaagatgaa 2451901 gctgtgcggg gtcaatggca aacggatcac cactgagaac tgtaaaatcc gcgtcatagc 2451961 cttccgcaat ttttccgcgt gacttctctt tataaatgat accggcgcta ccttctgtat 2452021 aaagctttat cgcttcatat acaggtaaac attcactttc attatagctt ggcccgtttt 2452081 gctcatgact gcttttccgg aggaccgcgg actggatccc tagaagcggg tcaacaggct 2452141 caatcggggc gtctgaaccg cccgcgcata aaatgccttt agatatgagg gttttccagg 2452201 caaatgcagt cttcatccgg tcttttccga gacggtcaat gacccacgga aagtcgcttg 2452261 caacgaagtg cggctgaagg tcaagtgcga tcggcatgcg tgctgctctc tcgattaatt 2452321 cgttatcaag cacttgagca tgaataagcc gatcatgccg gccgtttttg ggcggatgct 2452381 tttctattgc gttcagcact ttttcaaaag caagatcgcc gattgcatga acagcaacct 2452441 ccatcccttt ttctctcgct ttgcgaatga gccggccaag ggtttcgtca tcgtgaacct 2452501 gaacaccatt tgttgatgga tcatcctgat atggttcttt caataaagcc gttctcccgc 2452561 caagcgcccc gtccgcaaag attttcatag caccgaactc cacatacggg ccggacagct 2452621 tctccagctg ctcccatcga tcgacagctt catgatgaac gagcaaatgg cagcgaaacg 2452681 gatactttcc gccagcggca gctttctcat aagctttcat cggcaccgaa acatcaccat 2452741 aataggacaa gtcttccgaa tgaccgcccg tcaggccttt tgtccagcaa tcctttattg 2452801 cagccgttaa tgcctcatca acatagtgct gggagactgg cgggacagcc ttcagaatca 2452861 aatcctgcgc cttatcaaac aggagtccgg tcggctcgcc atttgcatct tttacgatga 2452921 ctccgccgtc aggatcagga gtatttcttg aaattcccgc tgcttgaaga gccgcagaat 2452981 tgacagctat tgcatgccgg catatacgct tgagcaagac gggcctgtca ggaaacaggc 2453041 gatcaagatc atgcttagtc aagtagtcag gtgtctcaaa ctgattttca ttccagcctt 2453101 ctccaatgag ccaatcgttt ttaggaagct gccgctctct ttccttcgca gcctgtaaaa 2453161 ttgaatcttt cgacgtcagt gcggacagat cgagctgaag ctgtttctca ccgtggccga 2453221 tcaaatgtag atggctgtca acaaaaccgg ggaacatcac tgctccgttc aggctgattt 2453281 cttctgtttc cggcgacccg tacttttcct tcaaacgttc atagctgccg gtgcctttta 2453341 taacaccatc ctcaacataa actgcctcag tccgatcgcc ttcttcgagc atcgtataaa 2453401 tgaaaccgcc gtgccatatc gccttcattc acgttcactc tctttcttta cgccttttta 2453461 ttggctttga gctgttcttc acgttttctt aattccactc gtctgatttt tgcagaagcc 2453521 gttttcggca ggctttccac aaattcaatt tctctaggat atttgtatgg agcggtaatc 2453581 gtcttcacat ggttttgcag cattttgaca agctcatcac tgcgtttttc atgattttgc 2453641 aggacaacat atgcctttac gatggagcct ctgatttcat cagggcttgc gacaacagca 2453701 cattctttta cttctgggtg cttaacaagc gcgtcttcca cctcgaaagg cccgatcgta 2453761 tagccggagc tgataataat atcgtcattt cggctttcaa accagaagta accttcctca 2453821 tcttttcttg ctctgtctcc cgttaggaaa taatcgccgc gaatttgtgt tttcattctt 2453881 tccggatctt taaaatactc tttaaagagc gcaggcgtac tgaggtgaac agcgatatcg 2453941 ccaacctcac caggtttgca gatttcaccg tcttcattta tgatctccac ctgatttccc 2454001 ggtgtcggtt ttcccatgct tcccggttta ataggcgtat ctttcaaaac accaaccaaa 2454061 agcgtgcttt ctgtttggcc atatccgtcc cgtaccttaa tgccaaagtg cttttggaaa 2454121 acatcaatga cttcacggtt gagcggctca cctgcggaaa cagcgctgtg cagggcagaa 2454181 agatcaaagc gtttcaagcc ttcaaccttc gccattaagc ggtattctgt cggagtgcag 2454241 cagaaaacat tgattttgta gcgatttaaa agctctagat atttttctgc tttgaatctg 2454301 ccgtggtaca caaaaccggt tgctccgctg ccaagcaccg ctaaaaacgg actccatacc 2454361 cacttttgcc agccaggggc agcagttgcc cagacgatat ccttttcaga aatgtcaagc 2454421 caagcgccgg cagaagtttt taaatgagca aatgcccatc catgtgtatg tacaacacct 2454481 ttcggctgac ctgttgtccc ggatgtataa gataagaaag ccatatcatc tcttgttgtg 2454541 tcagctgttt taaattggct tccgtccgct tcaattgata agaggttttt ccagccggca 2454601 tcattttcac caatagacag tgtaatcagt ttgtcagccg tactgacatc ccggaaagcg 2454661 ccaataaatt cggagtagac gatagcgcct tttacctctg catgttcaat ccggtattca 2454721 agatctttcg cgcgaagcat ttcggagcac ggaatgacaa ccattcctga tttcaggata 2454781 gccaaataaa cagcataggc ttcaagcacc cgcggaacca ttacaatcag cttgtctccc 2454841 tttttaaatc caagatcagc taaggccgct ccgattttat ttgtttcttc catcagcttt 2454901 tcatacgacc aagattcttg cttgcccgac tcgtcctccc aaagaagagc ggttttttgt 2454961 ccagcagcac tgaacttttc catttcattc actaaattat attgcacagg ggcaattaaa 2455021 tcttcacgtt ttaacacgaa caactcctca ctttctccac ccattataca taaatacagg 2455081 ctctttccgt aaggatatgc ctaaaagcaa cctctgtaaa catagatttt ataggccgct 2455141 ggtccttttt tatatgtaaa aaatgaaaaa gagtggggat acccccactc ctaagccatt 2455201 atgtgaaatt gtaaattaga attgtcctcc gcccatgttt tgttgagcaa aagatacaag 2455261 acgttttgtg atctctcctc caacagaacc gttagcgcga gaagttgtgt ctgctccaag 2455321 gtttacaccg aattcagaag cgatttctaa tttcatttgg tcgatcgctt gagcagctcc 2455381 tggtactaaa aggttgttgc tgttacctga gttattgtta gccatgtgtc tcacctcctt 2455441 gtgagtatag aatgtgtcaa aacacatggc ttcattcaga aaaactttgg taattgtata 2455501 caggagctga aaattgattt aaaagagttc agcgaattta tcgttagctt cttgttcgct 2455561 ataaagggtc attgtctcaa tgttatctac cgcttcttga atatacggct cgaaatcaac 2455621 aaagctttca aagtgttcaa ttttctcttt tttagggcgt gttttcgggc ttggcggtgt 2455681 aaagatcgtg cagcagtctt caaacggctg aatacttgtc tcatatgtgc caatttcccg 2455741 tgatttttcg atgatttctg ttttgtccat ggcgattagc ggacgcaaaa tcggtgttga 2455801 cgtcaccgca ttaattgcat acatgctttc aagcgtttgg ctcgctacct gaccgaggct 2455861 ttctcccgta ataatggcaa gcccgtttct cttttctctg attctgtcgg ctatctgaag 2455921 catgaggcgg cgggttgccg tcattgtgta attttcagga atttgttttt ggatgagctc 2455981 ttgcgttttt gtaaatggaa caatatgaag tgtcatgctt cccccaaaac gggacagaca 2456041 tttcgccaga tccattacct tttgctttgc gcgctcgctt gtgtatggcg ggctgaagaa 2456101 atgaacagct tctaccgaca atccccgttt catcgcataa aaaccggcca cagggctgtc 2456161 aaaaccgcca gaaagcatca gcatcgcttt tcctgctgaa ccaactggca gcccgcctgc 2456221 acctttttca tcacgaattg tcaaaaatgt tgcttcttcc ctgatttcga ttctgagcgg 2456281 gatgtctggg ttgcgaacat cgaccgtcaa tccttctgta tttcgcaaaa tatggccgcc 2456341 gatttcagcg ttcatctggt ttgtatctaa ttcaaattgc ttatacgctc tctttgtcgc 2456401 gactttaaac gtatcacctg gtttatactg atctttgata gcctttagtg cggttgcctt 2456461 aatatcatca aggcggctgt cacacttaat tgccaggctg aagctttgaa tcccaaacac 2456521 ttgctttaaa tgaggaaaaa gagcctcagg atcctctcca tttaatgtaa tcgtcatacg 2456581 atccctgttg gaaaagtatt ttaaattcgg atagtctttc aaaacgagtc tgatgttttg 2456641 ttttaagcgc tcaataaagc tttttctgtt tttgcctttg gtcgaaattt ccccaaaacg 2456701 aattaatata tgatcgtaat tcatgttcta cctcatcatt tcccttaatt ttttgatgcc 2456761 aggacgaagc gcgttcataa acggttctgc cacatcgctt gtctggctgt aatttaaact 2456821 gattctgatg ctgcttccgg caatctgctc tcctttgccc atctctaaga gaaccttgct 2456881 gggcttatgt tcttttgccg agcaagccga tgttgtggag acgaatatat cctgttcctc 2456941 aagcatgtgt aaaagcactt ccgctttaat ccccggtaca gagaaattaa taatgtgcgg 2457001 cgcgctattc atttgaggcg tgttgataac gacgccctca atttcactca gcctattcat 2457061 aaacaattcc tttacggcag tcatcgtgtc aagccgtgtg tcaaaatcag cagaggccag 2457121 attaatggcc ttggcaagcg aaaccgcacc agcagtatgt tctgttccgg cccgtatgcc 2457181 tttttgctga gagcctcccg ttatgagcgg aataaggcgt gttccttctt ttacaataag 2457241 tgcgcctgtc ccctttaggc cgtgaaattt atgccccgaa attgaacata gatcaatgcc 2457301 ggccttttca attgccaagg gcactttata gatgccctgc acataatcga cgtgaaacaa 2457361 aatgttcgaa tgctctttca gcacttctcc tgccgcttca atcggctgca cggaaccgac 2457421 ttcattgttc acatgcatca tgctgacaag cacggtatcg ggacggatgg ctgcttttag 2457481 atcttcaata gaaacaaatc cgtcttcatt cacagaaaga taagtgatat caaacccgaa 2457541 caactctttc agctgttcta acgattccgt aacggatgga tgttcaatag aagtggcaat 2457601 gatatgtttg cctgttttta tctttgacaa agccgctcct tttaaagccg cattattggc 2457661 ttctgtggcg cctgacgtaa atacaatatc atattttttt aggcctaagg accttttgat 2457721 ttgatttttg gctgcttgaa gcagctgttc cgtttcggct ccatatcggt gcaaagatga 2457781 aggattgcca aagtatcggc tgctcgtctg ttcatatacg ttcaagactt catcgtaagg 2457841 cttcgtcgtt gaactattat ctaaatatat catctttttt actcctttat gaaagcggta 2457901 caaggtatga tatttatgtt accataacaa aatttaatag aaaattacga aaaactagta 2457961 ttgacttcta atttttttac catataataa gatttgttcg tttcgtcata ttatctgaca 2458021 attaattgac agaatatttt aacataatta ttaggaggat ttttttcatg aaacactcac 2458081 tgcctgtcaa agataccatt attattggtt tcatgctatt tgcgttattc tttggagcag 2458141 gaaatatgat ttatccgccg gaacttggac aagcagccgg acacaacgtc tggaaggcca 2458201 tcggcggatt tttactgaca ggggtaggcc tgccgcttct cggcattatc gccatcgcat 2458261 taaccggtaa ggacgctaaa ggccttgctg acaaagcgca ccctgttttc ggcacaatct 2458321 ttactgtcgt gctttattta tcaatcggac cattattcgc catcccgaga acaggaactg 2458381 tttcatatga aattggcgct gttccgtttt tgactggtgt accagaaaga ctttctttat 2458441 taatatttac acttatcttt ttcggcgtta cgtactattt agcgttaaac ccatctaagg 2458501 ttgtggatcg agtcggaaaa attctgactc ccatcaaatt cacaattatt ttaatcattg 2458561 ttctcaaagc catcttcacg ccgatgggcg gattgggcgc cgtgacagaa gcatataaag 2458621 gaacaccggt ttttaaagga tttttagaag gctataaaac aatggacgca cttgcttcaa 2458681 ttgtatttgg cgttgtcgtt gtaaatgctg taaaaagcaa aggcgttaca cagtctaaag 2458741 ctcttgctgc agcctgcatt aaagcaggtg tgattgccgc tttaggcctg actttcattt 2458801 atgtatccct tgcttattta ggtgcaacaa gcacaaatgc cattggtcct gttggtgaag 2458861 gagctaaaat tttatctgcg tcttcccatt atttattcgg ttcattgggc aacatcgtac 2458921 tcggagcagc gattacagtc gcatgtttaa caacaagcat cggccttgtc acatcttgcg 2458981 gccaatattt ttcaaaactt attccggcat tatcatataa aattgtcgtt acgattgtca 2459041 cgttattcag cttgatcatt gcgaatttcg gactcgcgca aattatcgcg ttttctgttc 2459101 ctattttatc agctatctat ccgcttgcca ttgtcattat cgttctttcc ttcatcgata 2459161 agatctttaa agaaagacgc gaagtgtaca tcgcatgctt gatcggtaca ggacttttca 2459221 gtattttaga cggtatcaaa gcagccggtt tttcacttgg atctttagat gtgtttctaa 2459281 atgcgaatct tcctctttac agcctcggca tcggctgggt gcttccagga atcgtcggag 2459341 cggttatcgg ctatgtgctg accttattca tcggaccatc caaacagctt aatgaaataa 2459401 gttaatgtca cagaacgcct gcgttattgc gcaggcgttt tgtaataaaa aaagagcctg 2459461 ctcattacac tgcgggctct ttttcatggt cgtgattatc taagcggata tgtcagcttt 2459521 gattttttca actgcacctg gcgcagcctt ttctacagcg gcagcggcaa tttcataaga 2459581 gtcgtcataa tcaaaagcat aaaaacgtct ttccgcttct ttcagctgtt cagataaaat 2459641 atgattctgg cttctgaacc ggtttccgaa ctgaatgatt ttttcaatga ggatgacctg 2459701 ctcgacaagt tcctctgatt cccggcttgc cctgttgacg atatcttctg cttgtttcaa 2459761 atgggctccg gcttcttcca tatttaatgg aagttcgttt agttgattga ccgtttcttg 2459821 aatatgatga tgcgcgttct ccagcatctc ttgaatatgg ctcggaatgc ctggaatgtt 2459881 gctagtcttc agcagtcttg ctgtctcaga aattgttttt ttcaaattgc tgagcgtctc 2459941 cctcgcctga agctcttctt ttctcagcgc ttgcagattt tcacgatact cggcatgctc 2460001 ttttttcact tcttcaattt gcttctctat tgaagcaact tcttctacta aaagtgagta 2460061 ggcgacatgc tctgcatcaa gcttatcttt aacggatgat agcagctttc caatttcatc 2460121 aaggcgcttt tcaaaagcct gctgtttgcc gagctcaccg gctgtcagcc tgtagctttc 2460181 cttcaccagc tcagtttccg ctttcgtatg ctctttctct tctttaagct tgtcgtaagc 2460241 aataatcaat tcaggcattt tgcttagtac ggattgaccg gcttcaactt cgccctccag 2460301 ctgctgataa acagattgaa tattttcgtc aatgagctgc aggattgcgg acgcttcatc 2460361 aatatccagt tcagtcatca ggacatgttc cgctcgtttc agctggtttg acagattttc 2460421 taattcctta tcaagctgga tatgctcaag cttgtaccct ttttctttca tttcgccata 2460481 gccatccttg agctttgcaa tctgtccggg caccgtctgt ttacagtcag ctaacagctt 2460541 cggcacatca tctatgtatg actgaagccg ttcaagattg cggtcctgct caagcagtac 2460601 ttttcgtgca gtaatatagt ttccgccttc tgtttcttct tcaaattgtt tgatgccgct 2460661 ccaaatttcg tccagatcct tttcaaggct gtcataaagc tccccgtaaa ggtggctgta 2460721 agccagcagg ttttttcgag atttcgaata gcgctccctc acctgttcaa tctcttcacg 2460781 gctcttttcc tcacttgtga caagatcgct gatttcccga agaatctttt caatgcttga 2460841 ttcagccgct gtcagcaggt cgtcgatatg aacgagcact tgattggcct ttttaaaccg 2460901 gtatttgtct gcattttcct cggcatcata aaggagctct tcaactttcg gcatgtgggc 2460961 tgtgacaatc tcatcccatt cttcacgcca cttctcaaag aactcttctg tctgacccgt 2461021 catttttaaa tgttttattt tagacatttc ttccacgatc gaccgattca gaatttcaat 2461081 cttccacgat tccagccggt cgatttcggc gtagattttt ttcctgaaaa agtagcctgc 2461141 cgcaaacagc gcaagcagta caattaataa tccaatgaca aactccataa tgagccccct 2461201 tgctgtttac cttaatctgt cagggtgttt tatttattca gaaagatttc aggatatgta 2461261 ttgagaaaaa ctgtcgtttt cattgttatt atgataccat gtaacaaaca ttttttgacc 2461321 agaaatcaaa aactttttgt gcaaaatcgg caggatttga ctattttttc atggggtgac 2461381 atcaatgcaa aagcgagacg gacatattca cacaccattt tgccctcacg gctccaatga 2461441 cacactcaga caatatgcag aagaagcctt aaaaaaaggg ttcgaatcga ttacttttac 2461501 cgaacacgcc ccattgccgc catcttttac cgatcccacg ccgctgaaag acagcgcgat 2461561 ggcgcaagct tctttggaac gctatattca tgaaatttcc ggattaaaaa aagaatatcg 2461621 cggacagctt agcatacgga cagggcttga agtcgattat atcgctgaat ttgaagacga 2461681 aattacatta ttcctagaca catacgggcc atatttagat gacagcatct tatccgttca 2461741 ttttttgcgc acagactctt cctatctatg ccttgattat gacgagcata ccttcaaaga 2461801 gctgatttca gcctgcggaa gcattgaagc ggtatatgaa caatattacc ggagtatcta 2461861 ttcttccatt gtagcatctc tcggcgttta taagccaaaa agagtcggtc acatcacact 2461921 cgtccaaaaa ttcatcaagc tgtttccata cagcatgtca gagcatattc gcggcctcgt 2461981 ttctctgtgc ctgaatgcca ttgaagaaaa cggaatggag ctcgacttca atacttccgg 2462041 cttaagaaaa acttacgctg gcggtattta tatcgaggat tggatgctga atgaagcgaa 2462101 gcaaaagaag atcccgcttg tgtttgggtc tgatgcccat caagcgggag atgtcggata 2462161 tgcgtatgag gcgtttttgg aacggtgcta gttggtgagc gccacgtctc ctgtccggaa 2462221 gacgcttctg atccaaatct tgatttcttc aaaatacatt ttataaaaat acggctcgtg 2462281 cggctgcatg tagagtactt ctgaaatata ttgaggctgg agatagggca tcatcaagag 2462341 agattttaat tggagaataa aatgaggcag cggcagcgtt aaatattcac gctgtttttc 2462401 tccttcctca atgatcagct ggaagatata cttttccttc attagatatg tcgacataat 2462461 ttccctgatt aatgtggagt caattgtgac ttcccggtag acaaaacgag ttaattgacg 2462521 atgattatgc tgataggata aaatatcgaa aaccaattga agaagctgtt cctgcgtgct 2462581 ttgagtagag atattgcttg ccgctgtttc aagcgttttg ctgtagcctt cgtaaaactc 2462641 tgaaactaag tgttccatca agcctccttt gcctttaaaa tagtaggaga tgtgcgcaac 2462701 atttacatca gctgactttg cgatttcacg gacagacgtg ccagaaaatc ctttttggtt 2462761 aaaaagcatg acagcagatt caataatttt gtctttggtg cttactttca tacggctcac 2462821 tccttcctct tgatactatt caagcagaaa gccgctgttc ctgtaagaac ttatcgacaa 2462881 atgccggcag aaaagccgga actttgtttt atattataga aaaagtgagg gttttccatg 2462941 ttccatgtcg aaaaacaatc tggagataaa gaaaaagact atcagcttct gctaaaacag 2463001 ctcgaagcca tgaccgaaga cgaaacagac caaatagcta actatgcaaa tgcctcagca 2463061 ctgctgtatc attcgctgcc tgaagtcaac tgggcgggtt tctattttgc caaagaagag 2463121 gatggacagc ttgtgttagg tccgttccaa ggcctgccgg catgtgttcg gattcctttc 2463181 ggcagagggg tttgcggcac agcgtacgca aacggaaaag tggaacgtat tgaggatgta 2463241 aacgcgtttc cgggacatat cgcctgcgat gcagcgtctc aatcagaaat tgtgcttccg 2463301 attcgtgtag acggaaaaat tgtcggcgtc ttggacatcg acagcccagt gaaaaaccgt 2463361 ttcgacgaaa ttgatgaaaa atacttaact caatttgccg aaacgctaga aaaagcgtta 2463421 gcgcagtaat ataaaagccc aaaactgata tcgttttggg ctttttttat tttattgagt 2463481 catgaatcat caagcggttt ttcccgctcc gtttcgcgct gtagagcgct tcatctgcct 2463541 catgcacaag ctctttcagc gacttttttg tttctgtcgt ccagcaggag ataccgcagg 2463601 aaatggttac ctcgggtttc gtattttttc tgaccgcgta aaccagtcgc tcggtaatcc 2463661 gtttccccac tgcaaccggc acatttggca aataaatcgc cagctcctct cctccccagc 2463721 gggcaccgac atcatgcttt cggatgttgc ttttaatcac tgaagcgact tgaattaaaa 2463781 tctcgtcccc agtctgatgg ccgtacgtat catttacatt tttaaaatta tcaatatcaa 2463841 caagaataaa aacacccttt tgatggattt tcatgctgta ttgaattttt tcatctaaat 2463901 acgctcgtga atacagttca gtcagctgat ctgttttcac gagatgctca aggcggtcgc 2463961 gaagcattga attggttaca gccagtgtcg cgtgatgaat cagcgcctga aacagcttgt 2464021 acatttcaaa tgtaaaagcg tacagctcct gtttcaataa aaccgcaaag cctaaaagcc 2464081 ggtcgttttg aatcatcgga gcagccatca gcgagccgta ccccgccttc ccaaaaacag 2464141 actggccatt cccgatgaaa accccttttt caccttcata cagcttttct ttcagctcat 2464201 tataaaaatc tgacggcttc gcttctttaa aaaatgctgt gctgcctggg agcaatgtta 2464261 ggttttcaaa atggtctata tgaaaaaatc ccacttcttc tgcctgaaac gattctgcca 2464321 ttctcacagc cagatcattc attgtatcag tcaatgtcag ccgctgattc aggcgtcgtg 2464381 atgtttcatt aatcaattcc aaatttgcga tgcttgcttt ggattgttcg tagagctggg 2464441 cattttcaaa cgcttttccc gcggcgtttg ctaacagcga catttcatca aggcaggcat 2464501 cagtaagaaa gctgtcaccc gttccttcag ccttcaacac cccgtatgtg ccctgctgtc 2464561 ctttgatcgg aatataggcg acagattcat ttttccgcaa aatgtctccg gacaaataca 2464621 ctttgagcgc aaaggaatcg gatttttccc cttccatata cagctctttt gcaggaatcc 2464681 ctaaacattg gtcttgatcg tgcgatataa ataaagaaaa ctcaaaaaga gaaaatgtgc 2464741 ttgtcaagct ttctaaaagc tgcttcagca catctgtctg atcaagcagt gaatggaaca 2464801 gctctgtcat tttgtatatc tttttttggt agatcgtttt gttatagagt ctttcctgtt 2464861 tcatcgactg gtttaaaaat gaagcaacca cgtccggaag cccttcagga atctcttcat 2464921 cctgcctgca cgcaagatgg aaacgcctgc cggagccgtc ctcaatcaga taacatgaag 2464981 cgtttatttt tgaagcggaa aaacgcgctt caccatctgc cagttttgtc acaaagtctg 2465041 atggtgacgg tgtaagcgaa acacaaaggg ttgaaaaata ggtttgaata gccgaagtca 2465101 gccatatgaa agagtcggtg aatgtgactt tttcagattt ggttaataaa aaatcgagca 2465161 tatgataatg aaaggcggat aattgatctt tagtttgttc taccatgttt ttatcaccta 2465221 aaagtttacc actaattttt gtttattata tcataaacgg tgaagcaata atggaggaat 2465281 ggttgacttc aaaacaaata aattatataa tgacctttgt gtgaaatatt gcagcctttt 2465341 tgttcagctt ctatgttttc attttgttcc ttatcaataa ggtgtatcgt gtaactctct 2465401 gctgctggag cgaggataca tgaaaacaaa atgtgcatgg tcgaatagag cagacggttt 2465461 ttattttcca caaaaataaa accaaaggag gagtcacatt atggctcgct atacaggtcc 2465521 atcttggaaa ctgtcccgcc gtctaggaat ctctcttagc ggtacaggaa aagaattaga 2465581 aaaacgccct tacgctccag gtccacacgg cccaggacaa cgtaaaaaat tatcagaata 2465641 cggtttgcaa ttgcaagaaa agcaaaagct tcgtcacatg tacggtgtaa acgaacgtca 2465701 attccgcact ttgtttgaca aagctggcaa actagctggt aaacacggtg aaaacttcat 2465761 gattctttta gattctcgtc ttgataacgt tgtgtacaag ctaggtttag cacgtactcg 2465821 ccgtcaagct cgccaattgg ttaaccacgg tcacattctt gtagacggaa gccgcgttga 2465881 catcccgtct tacctagtga aacctggtca aacaatcggt gttcgcgaaa aatcaagaaa 2465941 cctttctatc atcaaagaat ctgttgaagt gaacaacttc gttcctgaat accttacttt 2466001 cgacgctgaa aagcttgaag gtactttcac tcgtcttcct gagcgttctg aacttgctcc 2466061 ggaaattaac gaagcgctta tcgttgagtt ctactctcgt taatcgtttt aaaaacccct 2466121 gccgctatgc ggtcggggtt tttttatcgg ctttcgcctc ttgctggcca acactatctt 2466181 gcgcctgctg ctcccaatga tcccgctgca gccgttcttt tgcaatcgta cacatgagat 2466241 tcacgcttta gcgctccttt catttaaaag gtggtgattg gtcgtgtttg ccctatctaa 2466301 tatactcttt tcctttcatt cctatgcggt aaacaaaaag atcctttgcc ttcagtggca 2466361 aaggatcttt ttcttattta tacgtcacaa ggaagtattt tttcttcccg cggcgcagaa 2466421 cagtaaattg gttttcgatg cggtcttcac ctgatagggt ataatttatt tccgtctggc 2466481 gttcaccgtt aatgtaaaca gctccgtttt ggatgtcttc acgcgcttgg cgtttagaag 2466541 gagataattt agattgcacc aacacatcta caagtgaaag ctcttgggtg ctgtcaactt 2466601 ccatagaagg aacatcttta aagcctactt ttacgtcttg agcagaaagc tctttaatat 2466661 tgccgctgaa cagcgcttgg gagatgttga tggcttgctc cagcgcctcg cgtccgtgaa 2466721 caagtgatgt cacttcttct gccaggcgtt tttgcgcttc acgtttttct ggcgccgttt 2466781 ctgttttttc agcgtatgct tcaatttcct cttttgaaag gaacgtgaag tatttcaagt 2466841 atttgacaac gtcacggtcg tctgtgttga tccagaattg atagaattca tatggcgatg 2466901 ttttttcttt atcaagccag atcgcgccgc cttccgtttt tccgaacttc gtgccgtctg 2466961 cttttgtgac aagcggaatc gttaggccaa acgcttttgc tccttcttct tctgattttc 2467021 tgatcagttc aagacccgct gtgatgttgc cccactgatc gcttccgccg atttgcagtt 2467081 tacagttttt gtctctgtaa agatttaaga aatcataaga ttgaagaatc atgtagctga 2467141 attccgtgta cgagatgccg gattcaattc ttgagctgac cgtatctttt gccagcatgt 2467201 aattgatgcc gaaattttta ccaacgtcac gaaggaaatc gatcacattc attttgccga 2467261 tccagtcaaa gttgttcgcg atgacagctg ggttttctgc tgcttcaaaa tctagaaatc 2467321 tggacagctg gtttttgatt ttttgggacc attcggatac gatgtcagca gtgtttaatg 2467381 tacgctctgc tttttttccg cttggatcac cgatgaggcc cgtcgcgccg cccacaagcg 2467441 caatcggatg atgccctgca agctgaaaac ggcgaagtgt taaaataggc agcaggtgtc 2467501 cgatatgcaa gctgtctgct gtagggtcaa agcctgagta caagcggatt ttttcttcat 2467561 tcagctgttt atttaaccct tcttcatctg tcatttgctg aatcaatccg cggaaggata 2467621 agtcttcaag taagttagtc ataagataaa gctccttttt taattaaaat aaaaaacgcc 2467681 ccttcgttta cacgaaggga cgattgatta tcgcggtacc accctactaa taagagaatg 2467741 caaacattcg tcttatcact ttgcctgata acggatcagg tccgttcttt cactactgaa 2467801 agcctggccg gctttgtttg caaaagcggt tcatgagtgt attcgatata tccgtctgtg 2467861 ctgattttca ccggccatca gctctctgga acgtaaggat attctacttg tctcaatctt 2467921 taccttttca tatgaagcta tatcattttt aacataaata aaatcctgtg tcaacgccgc 2467981 cttttaatcc tccattgttg acagatctcc agccggcaga ttaagctccc atgccttcag 2468041 cacgcgcctc atgatctttc cgcttctggt tttcggaagc ttatctttaa attcgatctc 2468101 acgcggagcc gcatgggctg caagaccctg ctttacaaat aggcggatct cttctttcag 2468161 tttatcagac ggctcaaatc cttccctgag tgcaataaag gctttaatga tttctccacg 2468221 caccgggtca ggctttccga taacgcctgc ttctgcaata gccggatgtt cgacaagctt 2468281 gctttccact tcaaatgggc cgacgcgctc accggaggtc atgatgacgt catcaactct 2468341 gccttggaac caaaagtatc cctcttcatc catgtaagca gaatccccag acacatacca 2468401 gccgcccggc atgaaatacg attcatactt ttcagggtta ttccaaatgg tatgcatcat 2468461 ggaaggccag ccctttttga tggcgagatt gcccattcgg tacggcggta gctcgttgcc 2468521 ttgattgtca acgatcgctg cctccactcc tggaatcggc ttacccattg aacccggttt 2468581 aatatccatg caaggatagt tgcagatgag ctgactgccc gtttcggtca tccaccaggt 2468641 atcatggatt cgtttgttaa aaactttatg tccccatctg atgacttccg gatttagcgg 2468701 ctcaccgaca ctgagcacat gccggagtga agttagatca tatttcgcag ccatttcatc 2468761 tcccgctccc atcagcatcc gaaaagctgt cggcgcgctg taccagacat tgacgccaag 2468821 ctgttcaatc gttccatacc agctttccgg gctgaaacgt ccgccgacga tgacatttgt 2468881 cgctccgttc agccacggtg caaaaatgcc gtataccgta cctgtcaccc agcctggatc 2468941 agccgtgcac caataaatgt cttcttcctt taaatcaagg acccactttc ctgtttgata 2469001 ttgctgaatc atcgcttcat ggacatgcaa cacgcccttt ggcgtaccag tggaacctga 2469061 tgtatagtga agcagaaagc cgtctttttt atccatccat tcgatatcca atcttgtgct 2469121 ttcctgtttc gctgcttcat cataattgat gatattcgtg ccgctctcag cctctccccc 2469181 gactacgaag acatgctgca agtgaggcag tttgtctacc ggtattctct ccagcagctc 2469241 aggcgttgtg acaacaacct ttgcctcact gttttcaagc cggtctttca ccgctccctc 2469301 cataaatgct tcgaacagcg gcccggcgat ggcgccaatt ttgattgcgc caagcataat 2469361 aaaataaagc tcgggtgatc tcggcataaa aataaaaacg cggtcccctt tttccacatt 2469421 tccataccgt ctcagcacat tcccggctct gtttgattct tccttcattt ctttaaatgt 2469481 gtatttttca tccctttttg cgtctttata ataaagcgct actttgtttt ttcgaaacga 2469541 ttcggcatgg cggtcaatcg cttcatacgc cgcattcagt ttccctgtct catgccaaga 2469601 gaaatgtttc tctgcctcgg cccaatcaaa atgccggtac gtttcttcat agttttttaa 2469661 gttatgatcc ccctctattg ctggtaacgc tttcaagttc atgcccaaac atcccccttt 2469721 gctgaagttg tcacaattat tatagtatat attcatattc ttctcaattt ttaaaatata 2469781 aaccatgttg aaaacgcttt ataatttggt attcttaaag aaggcatgta tttttgataa 2469841 gaattgatgg gacggtgaat tagtggaaca tcataaaaca taccattcag caaacatcaa 2469901 aacagcaacc ggctctttac tgatagaagg gcctgtctct ccagaggatt tggcaggtta 2469961 tgagtttcat aaagatttaa ccgcatttcg cccgcctcgc gagcagcatg aagcgctagt 2470021 cgacattgca ggccttcccg aagggcgcat tattattgcc agagacggcc gaaccattgt 2470081 cggctatgtc acgtatttat atcctgaccc gctcgaaaga tggtctgaag gaaatatgga 2470141 ggatttgatt gagctcggag ccatcgaagt agcgccggac tatcggggat gcgctgtcgg 2470201 aaagacgctc ctgaccgtca gcatgatgga tgaacaaatg gaaaactaca ttgtgatgac 2470261 gacagaatat tactggcatt gggatttaaa agggatgaaa aaagatgtgt gggaatacag 2470321 aaagatcatg gaaaagatga tgaatgcagg cggattggtc tggtttgcaa cggatgagcc 2470381 ggagatcagc tcccaccctg caaactgtct gatggcccgc attggaaaaa acgtcagcca 2470441 agaatcaatt gagcaatttg acaggctccg tttttatcat cgttatatgt attaactgac 2470501 actgacaaag gggaaaaaat aatgattgtt gagcaaatca tgaaaagaga tgtcattaca 2470561 ttaacgaaga cggatacgct tgaaacagca atatgcaaac tgaaggaatt ccatatcagg 2470621 catctgcctg ttgtagatga agaacgacac gtgatcggca tgattacaga cagggacatg 2470681 aaacaggcca gcccgagtat ttttgaagaa aacaaacgaa gcctatttct cacacgaagc 2470741 gtagattcaa ttatgaaaaa ggatgttgtc tgcgcccacc cgttagattt tgtcgaagaa 2470801 atatcagccg tgttctacga gcatggcatc ggctgcctac cagtggtaca ccatcaaaaa 2470861 ttaataggca ttttaacaaa aaccgatttg ctgcggacgt ttgtcaaatt gacaggcgct 2470921 gaccagccgg gctcgcaaat tgagataaaa gtaaacgaca tcaccaaaag cctcgctgag 2470981 atcagcagtc tttgccaaga ccttcaagtg aaaatattaa gcgtgcttgt ttatccgcat 2471041 gacgatcccg gtgtaaaagt gcttgtcttc cgtgtaaaaa cgatgaatcc gctgccgttt 2471101 ttgcaggcat tacaaagaaa tggacaccac gtcgtatggc cgtcagagca aagggatctg 2471161 ctatgagaga cagtgtattt atctattctc catcctacca aacctatatg tttcatcagg 2471221 agcatccctt taatcagcag cgggttctgt taacatatga tttgcttaag acgatcaatg 2471281 cctttgatga tggagacatt gtcaccccca gactcgcttc agaagaggag ctttcccttg 2471341 tccacacgga cgattacatt caggccgtaa agcttgcggg cgccggaaag ctccccgctg 2471401 aagaaggaga aagctacggg ctcggcactg aagacacacc cgtctttgcc ggcatgcacg 2471461 aagcggcatc actcttggtc ggcggcactt taacggccgc agactgggtc atgtcaggac 2471521 aagccctgca tgcggcaaac cttggcggag ggcttcatca cggctttcgc gggagagcat 2471581 caggattctg catatacaac gacagcgctg tggctattca atatatccag aaaaaatata 2471641 gcgccagagt gctttatatt gatacggacg cccaccacgg ggacggtgtg caatttacat 2471701 tttacgataa tcctgacgta tgcacgctgt ccattcatga aacaggaagg tatttattcc 2471761 ctggaaccgg tcagatccaa gaaaaaggaa gcggaaaagg atatggctat tcctttaata 2471821 ttccgcttga cgcttttaca gaggatgatt cttttcttga ggcttaccgg acagcagctt 2471881 cagaagtcgc cgcgtatttc gagcccgatg tcattatcag ccaaaacggc gccgatgccc 2471941 attactacga cccgctgacg catttatcag caacaatcaa tatatacgaa gaaatccccc 2472001 gtcttgcaca cactttggct catcaatatt gcggagggaa atggattgca gtcggaggcg 2472061 gcggatatga tatttggcgt gtcgtgcccc gcgcctgggc cagaatatgg cttgaaatga 2472121 agggaattga cccgggtcac gagatcccgc cggaatggat tgttaaatgg caaaaacaat 2472181 gccccgtggc ccttccgtcg agctggagcg atccggctga tttatatcct ccgattcccc 2472241 gcaagcctga aattacagaa aaaaatgccc aaactgtcag caaagcatta tatgcgatac 2472301 gttctgaaca gcaaagaaca aagtaaaaaa cgacctttac gaagaggtcg tttttgattt 2472361 tttaatcact atttccacac gccgattttc cttcatgtgt tcatttgtct tgttatcctt 2472421 tactggcttt gtatccgcat aaccgacagc aataaagcgc ttggagggaa gcttctcttt 2472481 agacgtgaag tattgaatca ctccacttgc ccgtgctgct gatagctccc agttcgacgg 2472541 gtatcggtat gtcgaaatgt ttcggctgtc tgtatgtccc tcaacctgaa tgtcatttgg 2472601 aattgtttga agaagaacgg caatttggtg aagaagtgtt tcggcatttt tcagcacctt 2472661 tgcctcacct gtatcaaaca gcacagcctc ctgaagaacg agcacgacac cgcgttcatc 2472721 ccgtttggct gtcatttggg ccttcaaatg attgtctttt atatatgtat ttactttctt 2472781 gagaagctga tcctgctgat cctcttgctt cttcgtatca gatggggatg tattcttttt 2472841 ttctatggat gtttggtccg gctgaagccc gttgccttcc ttctggatcg agtccactgc 2472901 cgctttgaat ttttgcagat cgatttggga catcgaaaag agtaaaataa agaacacaag 2472961 gatcaaggtg atcagatctg taaaggttac catccagctg gatgaagatt gactgttttt 2473021 tccgcttcca ttccttcttt caaaacgttc tcttctaagc ttcatgtaca gatccctttt 2473081 ttgtttttac ttgttttggc tgcttctgcc attcttcccg tgagctgaaa acgaccagct 2473141 ggctttcaag gttgcgcggg ttttttccgg attgaacacc gataatccct tccaccatta 2473201 cctgcttgat gaaaatttca ctttctgttt tctcttcaag cttagccgcg atcgggttga 2473261 agaccatatt tgccagtaat gaaccatata aagtcgtcag aagcgcaatg gccatgtttg 2473321 gtccgagcat atgcgggtcg tttaagtttt tgagcatcag cacaagcccg acgagtgttc 2473381 cgatcattcc ccatgccgga gcgaattctc ccgctttttc aaaaactcgc cgcccttttc 2473441 ggtgccgttc ctccattgct gcgatttctg aatccatgac gagccgaatc gtttcttcat 2473501 cccagccgtc aatcgctaaa agcagccctt ttttcaagaa tggatctttg atttcccgag 2473561 cctgatcatc caatgataaa agcccgtgtt ttcgcgcgtg atcggaaagg gaaacaaagg 2473621 ttttcacaag atctttcaca ttgtcttcct ggcggatgaa tgcctgcttt aacacagagg 2473681 gcgctttttt cagctcactt ggcggaaaac tgataaaaac agcggcgcaa agtccccctg 2473741 ttacgatgaa gaaagaggtc agatcaagaa aagagcggaa accgcttact cccgatcctg 2473801 aaataatccc gataacaata ataatcgttc ctaacacaaa tccaacaggt gtaagataat 2473861 caaaacgttt catcatttct ccccatgaaa aaagcaagaa ttcaccataa aggtgaagct 2473921 tgctctttgt ttttcttatg acttggttga ctttctaagc tctatacggt gcggcagttc 2473981 gacgatatgc tcttcaaccg gctctttatt catgagcttc gtcagcagtc tcatcgcaac 2474041 ggcgccgata tcatatgtcg gctgaacaac tgttgaaagc tgaggacgaa ccatgaggct 2474101 taatcttgta ttatcaaaac cgataatgtc gagatcctcc ggaatggata agccctgatc 2474161 ctgagcggca tggataatgc cgagtgccat ttcatcagtt gcagaaagaa tggctgtcgg 2474221 ttttttatcc aggctcatca gatgctgcag tgcttcgagt ccggaatcat atgtgtaatc 2474281 cccttcagct acaaattgtt cattaaacgg aaggttcgct tcttcaagcg cacgtttgta 2474341 gccttggagt tttttcgaac ggttgatcgg ttctgccatt ggtccggaaa cgaacgcgat 2474401 gtctgtatgt cctttatcaa ccaaaagctt cacggcatca taaatcgcct gttcgtaatc 2474461 gatagcgact gacggtgttt cctcctgctc ttctacagaa gcggcaagta caatcggcac 2474521 tggagaacgc ttaaattccg ccacatgctc gtccgtaatg tttccgccca taaacacgat 2474581 gccgtccact tgtttgccga gcattgtgtt taacaagtgc agctctttct ccatgttttg 2474641 gtcagagttg ctcaaaataa tattgtattt atacattgtc gcgatatctt caattccgcg 2474701 cgcaagctct gaatagaaaa tgcttgagat atcgggaatg atgacaccta cagttgttgt 2474761 ttttttactt gccagccctc ttgccaccgc gtttggacgg taaccgagac gttcaatggc 2474821 ttccaagact tttttcctcg ttgtcggttt tacattcggg ttgccgttca cgacacggga 2474881 aacggttgcc atgcttacat tagcttctct cgctacatcg tagatcgtaa tattgctcat 2474941 cctaaaacca ctccttttac tggatacact tatccttatc tatagcataa acactttatg 2475001 tagagaaatg tcataatgtc cgaatttatg tcgtttatga tttgtaagcg taagtcagta 2475061 gtgtacatta tttttcatta ttcatcaaat ttaattactt ctcatgaaat tatacacgtt 2475121 tttatagatg atgaaaacgt atacttggtt tttataacta aataaacgag aaagcataaa 2475181 aaaaggccgc aggcgcggcc ttttggattg ttcaattaag cgttgacttt caccattggc 2475241 ttcagttcat tcagccattt ttcgaattca ggaatcgcca tttgctgagc agagtcagaa 2475301 agtgcgactg acggatcagg gtgaacctca gccattacgc catcagcacc gatcgctaaa 2475361 gcggctttag ctgtcggaag caagaggtca cggcggcctg ttgaatgcgt aacatcaaca 2475421 aagactggca aatgcgtttc ttgtttcaaa atcggcacag ctgaaatatc cagcgtgttt 2475481 ctcgttgctg tttcatatgt tctgattccg cgctcacaaa ggataatttg gtcatttcct 2475541 tgtgacatga tgtattcagc agcattgatg aattcagaga tcgttgcagc aagaccgcgc 2475601 ttcagaagca ctggcttttt cacggcgccg gccgctttca gcaattcgaa gttttgcatg 2475661 ttgcgcgctc cgatttgaat gacatcaatg tagtccagcg cttcttcgat atgagccgga 2475721 gttacgattt cactgataac cgccagatca aattcatccg ctacacgttt taaaatttga 2475781 aggccttcaa caccaagccc ttggaaatcg tatgggctcg tacgaggctt aaaggctcca 2475841 ccgcgcaaaa ttttaatccc ttgttttttc gcagctgcag cgacttcagc tacctgctca 2475901 tagctctcta ccgcacatgg gccgacaatg aatctttgct ggccgtctcc gattttttcg 2475961 cctttgatat caacaattgt atcttcaggt tttttcttgc gggagacaag cagcgctttg 2476021 ctgtgatctt cttcctgaag ctctaaaccg gctttgaata tctctttaaa aatgtgctgg 2476081 atggttgaat tttcgaacgg cccgtcattg ttttcaatga tattgtttaa cattgtgcgt 2476141 tctctgacag ggtcaaatcg gttgacaccc tgtgcttcct tcgctttacc gatctctttt 2476201 acaacattgc cgcgttcgtt gattaatttt aaaatttgta ggtttaattc gtctgctttc 2476261 tgccttaaaa gctctaactc tgtgttgctc atttttttca tcctttccct gcacattcat 2476321 tttttatttt gtagttatca tgcatcttac tataagtaat tccaaatgga aatactgaaa 2476381 tacaaaaaat tttataaaaa ctctacttta ttacccaaac gcttttaagt gataaagtaa 2476441 tctatgaagc tatcctacat gatgtgaggg caatgttcaa gggtttttta caaaaaaaag 2476501 cgccagatga tatctggacg cttttttcta tgacaaatgc tgctcaatag cggcttctgt 2476561 aatttgtgaa tgtgaggtat gccatttcac ttcaccgttc tggatgatga atatctgagg 2476621 gctttcatgc ttgaccccat atgtttctgc aatgaaattg gacagcggcc gggcttcttg 2476681 tacttgaaga tagtaagccg gcacatcctc atgctgattt gcaaaggcat caaactcatg 2476741 aaatgctgcc tggctgatcg ggcatgtggt gctgtgtttc aagaagacga aaacgccttc 2476801 ctgttctgca atccgtttaa attcttcctc agattgaata agctgtttag ccatgactca 2476861 agctcttcct tccctgctca gcgattcaac tgctcagcct gtttttgtgc atctttcagt 2476921 tcgtctttta catcttcttt cgtctggagg acttgatctt ttgtttcatc agctgcctgc 2476981 atcgcttctt ccctcatatc ttgcattgca gtcgatgaat ccgttttgtc agatttggaa 2477041 cggtctctca aatcctttac cttgttcatg atctgtccag actgatccgc tacaagctgt 2477101 gtgatgttgg aagttttgtc ttttgcgatg ctgacatatt gcgtgccttt ttccttcgca 2477161 tctgccgtca ttttatcagt tttgtcccgt aaggcaacag cctggctgcc gagatcgtcg 2477221 cgaagttctt tgcctgattt aggcgctaga aaaagagctg tagtggcacc gatgattccc 2477281 ccgattaaag ttccgattaa aaaatcttta ctattaattc catctttgct catcattatt 2477341 cctcctctta gtattttttt ctcttacagg gctgattttt tcttttgctt ccatttctcc 2477401 caaatttcca ttgctgcttg actccaagtg acaacttgat tgatcttatc ttgattctct 2477461 ctaactgatg ccgatacaga ccctgccgct tgtttcatgg atgtattgaa ctgctgtaca 2477521 gaagctccca ctccttgaac agcatgaacg accgtgttca gcttttctga tttttcctga 2477581 atatcttcag ccaggcggtt ggtcttatgt aaaagctcgg ctgtttcagt tgtgatgccc 2477641 ttcatttgtc cctccagccc ttcaagagtg gatgcgacgt tttttagtgt cagctgcagt 2477701 gacttcaatg ttttagacaa gtagatcact aatacgagaa atgcaactgc gatgagtgca 2477761 acgctcaaat aaagaataat aatcatctca aacctccttg ctgcaggata tactgctgtt 2477821 tacccgtttt cttcaatcat aaacatgtgt actgggctgt atacatacta ttctccgtta 2477881 tgtaagaaaa tcctttaata agctttccca tcagataaat aaaaagcagt gagatcactg 2477941 ctttttatta tgccatgacg ttttcgtagg ctctcatata tttttggata tctcctgctc 2478001 ccatgaagat gagaacggct ttatcatgag cttttaaaac agatgtgtca tcttcttcaa 2478061 tcagcttggc attatgaatt tttccctgga gatcaccgat cgtcagcttt ccggcattct 2478121 cacgggctga gccgaaaata tcgcataaat acacacagtc ggcgccgctc aggctttctg 2478181 caaattcgtc aaggaactgc tgcgtccggg taaatgtatg aggctggaat accgcgacaa 2478241 tttcccgatc aggatacttc tgtcttgccg cctcgattgt cacttttatt tctgtcggat 2478301 gatgggcata gtcatcaatc agcacttgat ccccaagctg cttctcattg aatctgcgtt 2478361 tgacgccccc aaaggatttg agagcatgct taatgatgct ggaatcaatt tcttcataat 2478421 ggcataacgc aatgaccgcc aatgagttta atacattgtg gtggccgtac gcaggaatat 2478481 aaaacgtatc atagaacgta ttgcggacaa agacatcaaa agttgtccct tccgtgcttt 2478541 ttacgatgtt tctggcttga aaatcatttt cttcccccgt gccataatac acaaccggga 2478601 cgttcgcatg gattttcggc agatgctcat cgtctccgca ggcaataatg cctttgttga 2478661 cttgaagagc catctcttgg aaagcgtcaa atacatcgtc aatgcttgag aagtaatcag 2478721 ggtgatcaaa atcaatattc gtcataatcg cataatctgg ctgatagctt aagaaatggc 2478781 ggcggtattc gcacgcttca aacacaaagt attcgctgtt ttcatttccc tggcctgttc 2478841 cgtctccgat taagaaagac gtcggttttg cgttttggat cacgtgagcc agcagacccg 2478901 tagtcgacgt tttgccgtgt gcgcccgtaa cggcaacact cgtgaatttt ttcatgtagt 2478961 cgcctaaaaa cttatgataa cgtatcaccg gaattccctc agacatcgct ttttctattt 2479021 caggatgcgt gtctgggaat gcgtttccgg cgatgactgt catgccgggt ttaatatttt 2479081 ccgcgctaaa aggaagaatc gtaatatttc ttttttcaag cgctgtttgc gtaaaaataa 2479141 atttttcgat atccgatcct tggacagtat atccattatc atgaagtatt tgggcaagcg 2479201 gactcatacc ggtccctttt attccaacaa aatgataaac agtcataatt gtacctccaa 2479261 caaacgtcta tctgttcccc agtatatgac gctcatttca atttgcgacc gcggcggctg 2479321 aaaagcctcc cttagcggcg tattttatat gttttgttat gtttagtatc aggttatttc 2479381 tttccgatta aacccagata tcaagatttg tctatgcaca gctgctgtaa agcggcatag 2479441 ctgttaaatg ctctaaacac tatcatacca tgtttggtgt gaaaatgaac ccatattatt 2479501 cgtttattaa atcacttgct gtgatcagca cctctcgagg cttgcttcct tttgcctcag 2479561 agatcatgcc ttccgcttcc atcatgtcga tcagccttgc cgcacgattg taaccgattc 2479621 tgaatcttct ttgcaggctt gaagtgctcg cactgttttg ctctacaaca aactcacacg 2479681 cttcgtaaaa cagttcgtcc tcttctttca gggcagatcc ttgtcttacg agctcttctt 2479741 gttcaaataa ataggtcggc ggcatttggc ttctgacgtg ggaaacgacg cggtcgattt 2479801 cccggtctga cacaaagtta ccttgcagac gaaccggttt tcccgagccg ttttccaaaa 2479861 agagcatatc cccttttccg agaagctttt ctgcaccggc tatatcaata attgttcggg 2479921 aatcaacctg gcttgagaca gaaaaggcga ttctcgttgg gatattcgcc ttaatcagac 2479981 ctgtaatgac atcgactgac ggacgctgag ttgcgacgag aagatggata ccgcacgctc 2480041 tggctttttg ggcgatccgc gcaatgcttt cttccacatc gtttggagcc accatcatca 2480101 aatctgcaag ctcatcaata atgacaacta aatacggcag cttttcaccc atttggtgtt 2480161 cagcggttaa ttgattaaag cggtcaatgt cgcggacacc tgaatgggca aaaagctcat 2480221 agcggcgctc catttcctca acgacccatt tcaaagcagc cgtagccgct ttagcatcag 2480281 taatgaccgg gctgacgagg tgaggaattt tattgtaagg ggccagctct accattttcg 2480341 gatcaatcag cagcaccttt acctcactcg ggtcagcttt ataaagcagg cttactaata 2480401 ttgtattgat gcatacgctt tttccggagc ctgtagcgcc ggcaatcaag ccatgcggca 2480461 ttttcttcaa gtcgataaca acaggatttc ccgaaatatc taatcccagc gcagctgtga 2480521 gcggtgactt gcttgtcctg aaagctgagc tgcgaatcat ttggcgcaaa tcaaccacct 2480581 tgctcgtgcg gttcggcact tcaattccga tcgtgttttt ccccggaatc ggcgcttcaa 2480641 tccgaatatc tttagctgag agactgagtt taatatcatc ggacaagttg gtgattttat 2480701 tcacctttac acccggttca ggatgcactt caaatctcgt gacagacgga ccctgggtta 2480761 catggaccac attggcgcgg acattgaaat ttttcaaggt caaatcaaga agctgacgct 2480821 gttcttcgat ccacgcagta tcatcttgaa cctgcgctgg cgggacatca agcagtgcaa 2480881 cattcggaaa tacatagctg ccgcggcgct cctctgcttt ttgctgttta tgcgtatctc 2480941 ttttcagcat catcacatta aaaggaacgg atggcccttt ttgagaagat gcgctttgtt 2481001 cagtcctttt ctcctgtaca ccaggccttt ttttcggctc ttctgaagct tcgcgaggtt 2481061 tgtctgcgcg aatttcctgc cggttttcaa gagttgcagt agacgatttg gaaccctgct 2481121 ccatgtgttc agttttctca agctctgtat ggctgtctgg ctgaacatct atcttcgttt 2481181 cctgagcctc tcccagggtg tcataatgat tatttattat gctttctgat ggctcttctg 2481241 attcttttgc cacagtttct gcttgagcca gagcctctga tgaatactca tgatcagtaa 2481301 ataaaggctc ttcctgacga atgtccattt gttcttcttg aacgaacggg gactcagcac 2481361 cttctgccgc gttttcatga tgattgtata ctgggctgtc tgacggctct tttgcttttt 2481421 catcctcaga tactgcctct gtctgagatt caggagctgt ttgctcttca tcaagttcag 2481481 cggagaaaac aggctcttca aatttctctg gctgctgctc cctttgttct tcctcagccg 2481541 ttgcaggctc ttcgcggcct acttcactgt ctgaaagccc ttcagccgcc gtatctgtga 2481601 gcatctcagg cggtgtttgc tcttcggctt gttcagctgg gaagaaaggc tcctcttttt 2481661 ccggctgttg aacgcctgac tcaaatggca ctttgttacc tgacggctcg gctggccgtt 2481721 tcgccagcgc ctcatcatgc tccgtatcct ttctgtttaa aacgccagaa ggctgttttt 2481781 caaattgggt atccgggaag aaaggacttt ctattttgga atgcgcctgt gtgtctgaag 2481841 caggatagcc gcgttcacgt tcgatctctt ctgacagcag tgttaccttc tcttttaccg 2481901 atttatccgg ttcgttcaat gtttcagaag gctttttcgg cacatccttt ttaacagatg 2481961 gtttttgatt gaatccatag acaggcgaag ggatatttgt cggtttaaac ggtttcttcg 2482021 ccggctctgc tgcttgatat gtatgctgct cttcttcatt tctgggacgc tctctgtaag 2482081 gtgcagcact tggacgaggc gcggatttcg gttcgtccga tggtgtgcgg cgccttctca 2482141 ggtcatgatt tttgtatccg tcaggcacga ctggaaaacg gaatttgcct tttggatatt 2482201 cataatatat tttaggatct tccaatcttt ttaattgtcc ttcaggatga tgtacttctt 2482261 gttgctgcgg aatttgagcg ggttttgtct cccgttcagc atcctcttcg ctttcgccta 2482321 aaaacaaatc aaaaaattta tgaagccaac tcataattta tctctaactc ccttatagtt 2482381 ttctgggacg gtttttagta taccactgct ggtcggccca gaaaagatta agctatcagc 2482441 agaaacaaag ccgctaaaca agggcttagc ggcttttcac atgattcgtt ttttttggcg 2482501 gatttatggg agtctaaaac tgaaatgcgt ctcccgcctc atagtctcct tctaacacaa 2482561 ggattccttt ttcagcaggg gcatccggca aatcaagctc tttcgctgag cagatcatcc 2482621 cgcttgacgg aacgccacga agctctgcat ccttaatgac aagtccgcta ggcatcacag 2482681 caccgacttt ggcaacgaca actttttggc cttggtcaac gttaggcgcg ccgcagacga 2482741 tctgaagcgt ttcttctcct acgttgactt tacatacgct taatttatcc gcattcggat 2482801 gtttttcttt tgattctaca taacccacaa caaacttcgg agataaatca acgactaatg 2482861 tttcttcaac gccgtttctg tttaaaatct cattcacatc ttgcacgaat gtttctgaga 2482921 gcgcaacagg gccgttttca tcaatggtca agtaagaaga cgcattgaaa atgttgaagc 2482981 ccgttgtttc ttttgtttcg ttattgaaaa ttttgacgac gtcgccgtgt ttttcatagc 2483041 ctaattgttc gcgtgtcaca tcttgaagag agatcaggag cgtgtctccc acaccttctt 2483101 tattataaaa agcgttcata agtaaaaatc ctttctaatc ctttttcgga cggcttttcg 2483161 ccaggataaa caccggttcc agctttcctt cattgtacaa aaatgatagg gcggtaatcg 2483221 ggacggtgcc gcctgcaaag aagctcatcg acatttgtcc tagaatatca taccccgatt 2483281 cattccggat gtcagcaaga atcaaaacgt cctgatgagg aacagagatc gccagctcac 2483341 cttctgcatg ctgcttatac tcatttaaga tcgcttcgtt caaaatccgg cttgcgtcgt 2483401 atccgtcgtt tgccctgaag aaataaaagt aattgccggc aaccgtatcc tctttgacaa 2483461 ccgtcggcag ggaacggaga ttaaatgcgg ccgtctctct gatccgctct tttgtccagt 2483521 tttctttctc aagcatgcgc tggtcaatta aacggtaggt tttcccgaga tctagcgcgt 2483581 aataaattct tgtctctgcg gtatgatcgt cataaatgag cgggatatct tcgctggact 2483641 tgtccgggaa ggaagtcgag cggatgaccg gataaatgcg agtttctttc ccggtcattt 2483701 cctgagcctt cccttccatt gccgtcatcg cttcggagac atagtacacg atctcatcaa 2483761 tggcttcgtc ttttttcagt tcccattttg caataatcgg cggcaaatcg agtgtaatcc 2483821 cttttttagt cgtttgatcc tcaacacgga gggtgtcttt ttctctgtca aacagaaagg 2483881 agcgattctc gtgctgaagg cgctgcttca gtatatctga cagcttcctt gaggtcattt 2483941 tcaaaccgat gtcctccttt acgctttagc gagagagtct gttaaaaact gttcaatttc 2484001 ttcttttgtt ttgcggtctt tgctcacaaa acgatttact tcttttcctt cattaaacac 2484061 cacaaagctt gggattccgt aaatttccca ctctgcacat gtatcaatga atttgtcacg 2484121 gtctacgtag tagtaggtga attcagggaa attcgcttcc agttcaggca ggaaaggctc 2484181 tacaaaacgg caatccgggc accaatcggc cgaaaacata aatacagacc aatcatcctt 2484241 taccgctttt tccagctctt gagttgattc aatttttttc atttcatatc cctccagttg 2484301 tttatgttct tacatgtttt ttatcgatac tcgtccattt ggatcatacc aaactgcttg 2484361 aggcaaaacc acttatatgc aacgaatgaa tatgtaagat tggctttccc attatcatta 2484421 tcatatttta tttgcattat caagctcgtt tcgtttaaca tcgtgtacat gagggtgaaa 2484481 tttacagatg gatatacata aggagggatt tttattatgg agtttatcgt ctatttagca 2484541 ggagaaatcc acagcaattg gcgcgaggaa attaaagaaa aaacaaaatc actgaagctc 2484601 ccgattacgt ttgttggccc gatggagaat catgaccgct cagacaatat tggtgaagaa 2484661 attatgggcg tacagccaaa tgccgtttta aaggatgaca aagcctctga catcaacaac 2484721 ttcagaaccg ccgtcctgat gaataaagca gactttgtga tcgccctgtt tggcgaaaag 2484781 tacaaacagt ggaacacggc aatggatgca tcatatgcga tcgcaaaagg aaaacccctg 2484841 attatcatcc ggccggaatc gctccaccat cctttaaaag agctttccaa taaagcgaat 2484901 attacggttg aaaccgttaa ccaagccatt aaggcccttt cctatctatt tgaaacagaa 2484961 taagaaaaaa gcttgtcgat ccgggcttac tgctcgttca acaagctttt atgaaaccta 2485021 catattttct ttaatcgcat ccactgtctg cttatcgcag gctgttacaa gtttgatgag 2485081 catttcttta gcagcagcat aatcatcaat atgaatgata gtagcgtttg tatgaatata 2485141 gcgggaacat attccgataa ccgctgacgg cacaccgctg ttcgaaatat gaaccttgcc 2485201 tgcgtctgtt cccccgccgg atacaaaata ttgatatgga atatcatgcg tttcagccat 2485261 atcaagaacg aattccctca ttccgcgatg catgactgtc gttctgtcaa gaatgcgcag 2485321 caaaaagcct tttccaagct ggccgaattc atttttgtct ccgctcatat cgtttgccgg 2485381 gctggcgtca agggcgaaaa acaagtccgg tttaatcata tgagaagccg tctgcgcgcc 2485441 ccttagccct acttcttcct gaaccgttgc acccgcatag agtgtattcg gaagctcttt 2485501 accgtgtaat tccttcagaa gttcaatgct taagccgcat ccatatctgt tatcccatgc 2485561 ttttgataaa attttctttt cattcgccat cgtcgtaaac ggacaaacag gcacgatctg 2485621 ctgtcccggt ctaatgccga ttttgatggc gtcttcctta tcatccgctc caatgtcgat 2485681 catcatgttt ttgatatcca tcggtcggtt tcgctgcgca tctgtcaata aatgcggcgg 2485741 tatgcttgaa atcacacccg gaaccggccc gttatctgtt tgaatttcaa cccgctgcgc 2485801 aagcaaaact tggctccacc agcctccgag cgtctggaat ctgagcagcc cgttgtctgt 2485861 aatggatgtc accatgaagc cgacttcgtc catgtgcccg gctaccataa ttctcggtgc 2485921 gtcctctgcg cctcgtctga ctccgaaaac acttcccagt ctgtcctgaa cgatgtcatc 2485981 tgcatatttg gctagctcct gcttcataaa agcacgaacc tgatgctcat tgcccggcgc 2486041 gccgggaagc tgcgtcagtg tttggaaaag cgctttcgtt tcttgattca tgttttcccc 2486101 tcatttctat gtagtccttt tattttatta gaaacaatga agttttccaa gcactctgac 2486161 ccaatctgct cgatcagccg cgtattgctt aacaggattt ggctgtttct gtataatgaa 2486221 aagtacgatc aaccaggagg tgctttattt tgaaattgcg tcatcttctt ttaggagcag 2486281 gacttggaat ttgtacggct gtcgttgtga gacaatatgt gatgaagcct tatatttctt 2486341 cagaaaaagc gcttcgaatt gtaaaatctg cttttaagca gcggggcccg attgacggat 2486401 catggattta cacccagccg gagccctaca atattaacgg agaaacggta caggtataca 2486461 aaaccggcat tacacgatca gctttcggag aattagaaca gtatgaagtc atggtggatg 2486521 cgaaaacggg agaaattgtt gatgtcattg atacaatcgc ctcttaacac cggacaagca 2486581 aaaaatagaa gccgctgcct atgcagcggc tcttttttat tatatcgcgc gaatcggttt 2486641 gtataccgga taccacatcg catcctgcac tgcctgtata atgtcttcag gctcttccgt 2486701 agcgacgcct tccttcattg cggtttttgc aacttcaaca gcaacggttg ccgaaacagt 2486761 gcgcaaatct tcaacttttg gaagcatcgg cgccccaggc accccgacat tgaccatacc 2486821 tgcgattgcc cgggcacatg cttcaaacat gccgtcggta attaattttg attttgtaac 2486881 aatcgttcca agaccgagac cagggaagac aagcgcgttg tttgcctgcc cgatatgata 2486941 cgtaactccg ttatattcaa ctggcgggaa cgggcttcct gtcgtgatca gcgcacggcc 2487001 ttctgtccat tcgattaaat cctccggctt tgcttcagaa agagttgtcg gatttgacat 2487061 tggcaaaatc gccggccgtt tcacatgtga cgccatttct tttacaattt cttcagtgaa 2487121 agcgccggaa accgtagatg tgccgatcag gatcgtcggt ttcgcctgcc gaaccacttc 2487181 aagaagatca atgcctccgc cgtctccgtt ccgctgataa tccttcactt catcagccga 2487241 acgggcatac ggcttttgga aatcaagaag ctgatccata tcatctgtta acagcccgtt 2487301 cctgtctatg caccagaagc gcttgtatga ttcttcttca ctcagtccct cgcgcaccaa 2487361 tgcttcccgc agctgttcgg caattccgat tcctgccgtt cccgctccga atataacaac 2487421 tctgtgatct ctcagcggaa ctttagacgc ttttgcacag gataagactg cggccaaaga 2487481 aacagcgcca gttccttgga tatcatcatt gaaggtacac actttatctt tatagcgttt 2487541 caaaatgctt cgcgcgtttt tcgccccgaa atcctcccaa tgcagcaatg cattcggaaa 2487601 tgtttctctc gccagcgcaa cgtagtcgtc aataaattgg tcataacgtt ccccgcgcac 2487661 tctggaatgc tggttgccga cataaagcgg gtcgttcaag aggctctcct gatttgtccc 2487721 cgcatctaaa acaacagcca gcactctgct cggatcaatg cccgcagccg ctgtataaac 2487781 cgccagcttg ccaatagaaa ttgcgattcc tccgacgccc cagtcaccga ttcctaaaat 2487841 tccttccgca tcagttgcaa caattaaatc gatcgtatcg ctttgatctt tatactgttt 2487901 aaaagcttct ttcataccgt ccgggtcatc gattgacaga tagagccctc gtggttttct 2487961 gtattcatgg ctgtatctct gaattgccgt tccgactgtc ggtgtgtaga caatcgggag 2488021 catttcccct aaatggtcat ttaacaggcg gtaaaacagc gtttcattcc gatcgtgcag 2488081 cgccgttaaa tagacatttt tgctcaaatc gtcaggctgt gcggaatatt gttcatacgc 2488141 tcttttcgcc tgatcatcaa ttgttaatac cttgggcggc agaaagcctt ttaaaccaag 2488201 ttcttttctt tcttcctcag taaaagcaac acctttgttc aaaaaaggaa cagagagcac 2488261 ttcaaggcct cttaatgttg tttgaatgtc tccttcgttt gttactctga attgtttcac 2488321 cctgcctctt cctttctgag cataatagta ctaggtttgc attattagcc ggaaaacatg 2488381 cagggtaaac ataaaaatat gctatcgctt cattcgctta actgactttt tgatgcttcc 2488441 gtcctcctcc cattgaaggg cgcgatactc ggcatcatgg taaaaaataa accaagcatc 2488501 tttttctgct gcgaacgcct gccatttctg cttttgcggg atagaggtca tcggataatc 2488561 atcgtaagcc agcacccata gcggattgcg gtgggcatgt gtcggcatca gatctgccat 2488621 atgtacggca gtttcacccg catcctcgca tatcaggaca ctgtgtccgt cgctatggcc 2488681 tccggtgtga tgcattgtaa taccctctgt gatcgttaag gtgtcttcaa aggttttgac 2488741 ttggccagct acagcctccc aattttcttt ccaatacgta tttttcgacc tgatattcgg 2488801 atggcgcatt tcgtcccatt caacagctga tgtataaatc actgcattcg gaaagacaga 2488861 gacgagccgt tcaccttcat attccgttaa accgcatgca tgatcaaaat gaaggtgtgt 2488921 cattgcgatc acatctatat cggcaaccgt taatccgagt gcagctaatg agggtttcac 2488981 attcgactct tgtgtcacgc catagtttcg tttttgttta tcagtcagct tgccgtaccc 2489041 aattccggcg tcaatgatga tattgagccc atccttttga atcaaaatag ggtctgttct 2489101 tagttcaatc tggttttttt cattgactgg atatttttta gaccaaagcg gctttggcac 2489161 aacgccgaac atggcgcctc cgtccatatg cgtcacgcct ccgtcaagcc aggtcaacgt 2489221 gatgtttcca attttcattg tttccatttt cacccccccc tatcatcatg gtagcaaacg 2489281 gcccataaaa aaaacagact cctgtcagag tctgtcttta cgttctccat tcaacctcag 2489341 cccgatagat cggctggccg agtgcagaga atttttcttc atattctgtc ataatattgc 2489401 cttccagatt gctgttatgc aaatcgagac tgacgtatgt cagcaggagg ccgtactcag 2489461 agaagctctt caaagagtac tcaaataaac ctcggttgtc cgttttaaaa tgaatcgatc 2489521 cgcctttgcc cattacttct tcatattttt tgaggaagtg ggaatatgtc aggcggcgtt 2489581 tttcatgccg tttcttcggc caaggatcag aaaagttcaa gtagacccgt ttcacttccc 2489641 ccggctcaaa cacatccgtc agcgtgtccg catctatatt cagaagcttt acattctgcg 2489701 cttcgctgtc ttttactttt tggacggctg tcacgatgac gcttttaaat aactcaatac 2489761 caatataatt gatgtcggga ttttgtttgg ccataccaga aataaattgg ccttttcctg 2489821 taccaacctc gatatggatc ggattgtcgt tgccaaacac tgtgttccat ttccctttat 2489881 aatcagcagg attgctgatg gcaatatctg cgttttcagc caaaaagtca tcagcccaag 2489941 gcttgtggcg cattctcata tgattgacac ctctatctat tatttcgact aacaacatac 2490001 catgaattaa aaagacccgc aagctcgttt ttccagtgta tctctcttaa ggccgagcgc 2490061 ataaaaaaag agggtcccgt ctgctggaac actcctttcc catgtataaa aacgctctgt 2490121 tttgaacaat ttaacccgta tgatactgaa gggatgtgta ccgttatggg tttacattat 2490181 gagcatcaag ttcatttatt gaaggatata ttgactgacc atcaattgga ctgctgcgga 2490241 acagtcgcag agtacgagca gcttgagcgt gtgattaaat cactgatggc aaacaccgag 2490301 cttgattcaa atttcaaaaa cgtgcttgaa gatgtttacc gctacagcca atcaggaata 2490361 tcgtccaaat ccatcgactc acacatacaa gagcatcaga acagcctgtc tcaatgggta 2490421 gagcaaatgg attcgtattc ctgattaatc aacaattcgt ttcatgagga tatgcagctc 2490481 ttccattgca tcatgaaatt ccttatcatt gccttttgct ttatgccagg caatgaaagt 2490541 aattgtttca gataacacat accaagccat tcgcaaccga aggctttctg tcagctctat 2490601 gccgtacatg ctcagccagc tctcccaagc tggcttttcg acgtagtggt acagcaaagg 2490661 cccgaggtcc atcgccggat cagcgatcat ggcgccgtcc cagtcaatta aatacagctg 2490721 gttgtcttca gacaatagcc agttattatg attgacatca caatggcaaa cgactttctc 2490781 accgaaatgc acttcatgca ggtgttcttc caaatacttg atcccttctt gaatcagcgg 2490841 cgaagattgc tgcacagcaa atacagcctg cttcagctga gacaaaagag cccccgggtt 2490901 cagcggttct tttccaagtc tcttcagcat gtccagcaag gcttttgatg tgtgtatttt 2490961 acgaagcaat tcagcaacgg gccgtccgct catgtcttta ggcttcagct ctctgccggt 2491021 catccagtgc tgggccgtaa tgacgtcccc attttccatc cgttttgtcc aaaccagctt 2491081 cggaacaatg ccttcggcgg ataaaacagc taaaaaaggt gagctattac gttttaaaaa 2491141 aagctgctgc ccgttatgtt tcgcataata tgcatctcct gtagctcctc cggcggggaa 2491201 gatctcccaa tcgctaccta gtaattgtcc caaccagttc atatcaatgt tcaacccatc 2491261 atttcttaaa atattttaga attaaggcta atcgtttcta gtctatccag cgaatgcctt 2491321 tttcgtacga atcgtataaa aataaaaaag acagctattg agagtctcat atgctaatca 2491381 atagccgtcc tttaaatttt agcgctatag cacaaacttc gtcaagcaaa actcttaaga 2491441 tctgatgcta aatataagat aaccgttccg atgccgttta ctgcaaccgt tttcttgatt 2491501 tctgttgggt cttcctgaaa tcctgatgga tcacataaaa gccgataagg tatgtcgttt 2491561 ggcagcctcc actcgacgga gtctggactc gcgtgatgga taacaatgat atctttccat 2491621 tcgtcaacct cgtcaagatc ataaagcctg tatgcgataa ggtgttcttt tagcgtcaag 2491681 cattcaagat ggcgctggat gtctgcagcg gacctaagac ggaatgcagg atgcgctttt 2491741 ctcagcgaga tcagcctgcg gatatagtga acatcttctt tgaatgtttc acggcgatcc 2491801 cagtcgagct ggttgatgct gtcactggat tgatagctgt tttccactcc ctgcttcgtc 2491861 cggaaaaatt cctggccgct gtgaataaac ggcacccctt gggcaagcaa aataatcgcg 2491921 gctgcaagcc tttgcctgct tcgctttcgg ctgtcatttt cttgaggaag cgcaaagctc 2491981 attttatccc aaaaggtgtg attgtcgtgt gattcgacat aattgatgga ctggcttggt 2492041 tccggaacaa tcggtgctaa tgccttccat ccggaagacc cggcaattcc atgcatcaca 2492101 gcttgtgctg attcaccgtt gccgagcgca aaccctgttg ccttaaggtg aaaggtgttc 2492161 ccttttacag cgtcacgaaa catatcatta aaaaagccga tgcccggcat tcttggcgcg 2492221 ttcgccaaag cagctttctg ttcatgcggc agcggtgtag ccaggtccca cccttctcca 2492281 aaaagcagga ttccgggctt tgccttagtt gctttctctt tcatataaag cacggtgtca 2492341 atatctaaaa tcccgaggag atcaaagcgg aagccgtcaa cattgtattc ttcaagccaa 2492401 tagaccacgc aatccgcaat gaattttctt gccatccttc tttctgatgc aatatcattg 2492461 ccaacgccgg tgccgtttga tggcatccca cattcgtcgt gccggaaaaa ataaccgggc 2492521 actgtctttt caaaggggga attctccctc ttatacacat ggttaaaaac aacatccaga 2492581 atgactcgca gaccgtgctg atgcagggta ttgatcattt gtttcagctc tgtttttctc 2492641 gtttgaggat catgaggatt tgaggcatag cttccctccg gggcaaagaa atgaagcggg 2492701 ttatatcccc aattgtatgc atcaagcggc ttctcttcat caactccggc aaaatcattc 2492761 accggcagaa gctccacatg tgtcacacca agctctttta catacgctaa tcccgaagaa 2492821 ctgccatttg cggtttgtgt atcagtttcc gtcagcgcta agtattttcc cttgtttatc 2492881 atgccgctgt tttcatggat ggagaagtcg cgaagatgcg tctcatagat gacggcatcc 2492941 acagggtgtg agaatggttt aagaggagca gtccatttca tttgatccgg gcgcaagacg 2493001 acgcccttct ctccatttac agtcacagcc ttggcatact ggtcaactgt ttccatccat 2493061 tctgaattgt tgcagatgca aaacaaatac tcatatccgt gaaggtcacc tgtgaccgtg 2493121 acggcataga cgcctttttc caagcgagtc atttggaatg tgcgcccgct tttattgggg 2493181 tgtgaaagct tgacagcagc tgaggttgca gcaggcgccc atactttaaa tacggtatga 2493241 tccgcggtat aaacggcgcc cagctctccg tcataataaa attcgtcatc aaacgctgcc 2493301 gtccggatga ccgcgccaat ttggagatcc gttttgtggc cgctggatgc tctgacgcaa 2493361 tggatttttc caaatgtcac aggatggtcg gatacgcaga cgtacttgta ttttgcttca 2493421 agggagtatt cctccctgac agccagagga aaatctgtta tttctgtctc aagccgaaac 2493481 ggcggtgtca tgatttcctt ttgttcagca ggaatcagaa cagtaatgat attcatgtca 2493541 tcgacatacg cttcgaagct gcggcggatg ctgaccatcg gaagctctct cctccaaaca 2493601 cgtttatgtt ttgattctta ggggtgaagg actagatgcc agacgaaacg gggtagtgcc 2493661 catgatttct ccgtcagcat ggaacgggat tttgtccttc gtgtaaaatg taatgtcctt 2493721 cgctttaaac atcgtaacgc catccatctt tgtatgtttt ccaaatgcca tgagacataa 2493781 aagccaatat tttttcaaaa acggctggtt ttcaacgatt acgatatcaa atgtcttctc 2493841 gcgcggattt gctaggggcg ccgccttcat gcctcccccg taaaacggat ggttggatac 2493901 aacggcaaac cagacatcat gaaattcgcg cgtctcgtct tccgtcgtac aagctaatgt 2493961 aaacggctta aaggttgccg aagcgtgcaa atgagaaagc ggatacacaa gaaatcgaag 2494021 gcggagaaaa agaaaaaccc gtctcaacgg aaattccatc gcctttttat tgacatatgc 2494081 gtcaaacccg atcccgatat gattcataaa ataaagaatc tgtgatttat cctgaaggaa 2494141 attgacgctc cctaaatgaa aggttcttgt taacgggcgc tttaccttct tgatttcctg 2494201 tatcagatcg atttttttaa tagagaaccc tcgcgaaaaa tcattatacg cgcccgccgg 2494261 cacaaagctc agctcaatat cgtcaacatc tttcagcccg ttgacaactt catgcatggt 2494321 tccgtctccg ccaatgacga tcaggcgctt cagcttatat tcctgtatcg ttgaaatctg 2494381 tctggcgagc acctcggcgt gtcccggatg ttcagttaaa aatgaacggt gctcaacctt 2494441 tcgtttgatc aattcttttt gaatggactt ccaaacacgc aggccgtttc gatgtcctgc 2494501 tgtcggatta ataataaaaa accaatggct catctttctc acctgcttat gttatgagaa 2494561 aaccgctcaa atcgttctct tttactccag ccactcctgt ctgcgatagg agtcagacat 2494621 gcagtaagac aatagagcct ttgcagcctt tacctgatga tgtttgatcg gagcagtgtt 2494681 tttcttctgc cgctcaatcc attcttccgc gctccgctta tccgctattt ctaagccgta 2494741 tggcggctcc gggtaatcga tgtacgacgt tctgctcaga agcaattttc gaaccggaat 2494801 ctcagcctgt ttttccttta cgatctttga cacaaccgag tccgtacgaa acaggctaag 2494861 ccctggattt aacactgatg cagtctgaga ggctgttttc ttgtcccaaa aacgattttt 2494921 agaccctatg tagacactgt cttcctcagc ctctaaaaaa gaaacgcaat aaatttccag 2494981 aggagaaata atcacaatgc ttaattcaac cgccgcctgc tgaattttca gcacaggctt 2495041 atacataata aaataagaat caggcagctg ctgggtcaga taacgcaaaa tgcggtcctg 2495101 cttcacttgg tttgagagtt gagatatttc tgaaagagta gagcttgccc atttgagctg 2495161 aaaatcatat aaatgccttt tataaaaaga agcaagcgcc accctgctct tcgggagcct 2495221 tacatgaata tcttcttcgt cctcaaacca ttggtgtctc tcttcttgta tatcggcttt 2495281 tatctcttct tttcttcttt tcaatgaaaa tttttttcgt ttctgcaccg gttccggttc 2495341 ttcagcactg gcttgccttt cttcatgctg gcgctccgct gcttctacta gtgaaagcca 2495401 gcgctctttt ttcaaacgta caaactggtt gatataatgg tacggatcaa gctcatatct 2495461 cgatatataa tcatgaattt tgatgatttg tgccatgttt gtttctccac tccgcaatga 2495521 attaagataa ttgaaatttg aatatttcct cgtattttgg tgattggttc aagtgtattt 2495581 gaaagagcga aaatcgttca gccatcatcg aaacctcgcc gctttcaaac ggaacatgag 2495641 ctggaaatcc atcttcgcct gtccattttc ttgccagcgt catatgagga tgatacggtc 2495701 ttttttccac ttgaaagccg gcctgaagta cagcctgctt cgtatgttcc cgcagtctat 2495761 caagcgtttt gtttttcttt ggctccagat gtaaaacgcg cggctttctg cggtcgccga 2495821 atacatctat cttgccaaac ttaattgaaa atggatcaat ttctgaagca atctctgcta 2495881 gcgaaccttc aagcttcttt atttgtgtct catccgccgc tccgagaaaa attaacgtga 2495941 tatgatagtc aagcgggtgc acccattttt gaaacgtcaa tatcggttcg tttttcgcag 2496001 cctggtagat cggatttgca attccctcag gtatgggaac gccgatgaaa taatgaggcc 2496061 gtatatctgg catccgtctg acactccctt ctttgacagc tattatttta tcaataaaga 2496121 ggctgtgcgg atagaggaac agtgtatgaa aacactctcg cacaaacgtt tattatgtta 2496181 ggatattata tgacacttgt tttattcaga aaggaatgac aatgttgaaa atcgttgcaa 2496241 acacagctga tctgatagga gatacaccgc tagtgagatt gaatcggctt cagccggaaa 2496301 atgcggcaca agtctattta aagcttgaat ttttcaatcc gagcggcagt gtgaaagaca 2496361 gagccgctta tcaaatgatc atagaagctg aacaaaacgg tttactcaag ccgggatcag 2496421 ttattataga gccgacaagc ggaaataccg gcatcgggct cgccatgaat gcggcagcac 2496481 gcggatataa agcaatctta gttatgcctg atacgatgac gaaggaacgg atcaacctac 2496541 ttaaagctta cggtgcagag gttgtattaa ctcccggaga ggaaagaatg ccgggcagca 2496601 tcaaaaaagc gaaggagctt gccgaacaaa ttccgaacag ctatattcca atgcagttcg 2496661 ataacactgc taatcctgat gcgcaccgaa aaacaacagc gcctgaaatc gcccgggcaa 2496721 tagaggaaat cggaaaaccg ctcggcgctt ttgtagcctc ctctggaacg ggcggaacca 2496781 ttaccggaac aggtgaggcg ctcaaagagc tttttccgga tatcacggtt catgttgttg 2496841 agccagcggg ttcgcctgta ttatccggcg gaaaacctgg cgcgcataaa cttgtaggaa 2496901 cgagcccagg ctttataccg ccgattttaa atgaagacgt ttatgatgaa attatcaaaa 2496961 tctctgatga agacgcgtat acgacgacaa gacggcttgc tgctgaagaa ggaattcttg 2497021 tcggtccttc atcaggcgct gcctgcttcg cggcaatcga aacagcgaaa cgcctctctc 2497081 ctgacaaagt tgtggtctgc atgacagctg atacaggaga acggtactta tcaactgatt 2497141 tatggtcatt tatttaaaaa aaggactggc ttcagcagaa gccggtcctt ttattttgca 2497201 agctcgtaaa tggcctgagc atataacgct gtcgatctca gcaggtcatc aatttcgata 2497261 tattcatcct tttggtgtgc gctgtcaggg cgtccgggga acagcgggcc gaacgcgaca 2497321 ccggctttta aggatctcgc ataagtcccc ccgccgattg agattaaatc agctttttta 2497381 cccagctggc cttcataaac cttttgcagg gttttgacta acggatgatc tgcggacacg 2497441 tgatgcggct tgctgtcttt gaattctccc agctcaaatt cagatgcgct ttcgaatgta 2497501 tcgcggatca ctttgctttc tgctgtcaca ggatagcgga tattgatccc gagctcgcct 2497561 ccttgccctt ctttatagcg cagtgttccg acatttaatg tcagctctcc gctgatttca 2497621 tcctcacagt cgatgtccag tttttttcct cttgtatcac ctgagaactt atctgtcaca 2497681 acttgcacaa accgctttcc tgcatcgtca agctcagtct gctggagaaa ttcgcacaat 2497741 aaaatgccgg cattgatccc attgttcggt tccatcgcat ggcaggaaag accgtacata 2497801 cgcaaaatga gctgtccgtt ctctattgca gcttcccctt tttggtccgt cgtgcggagc 2497861 atgtctttaa atgaagacag aatctcttca tttttcggcc cttcaatgac agcttccgca 2497921 gcgtcgggca ccatgtttaa gcgaaggcct gattgaaacg agacaagcac tgcctttggt 2497981 tcagcttgat ttgggcggtg cggaataagt aaagaagcat cgatgatccc tttttccgca 2498041 ttaatgatcg gaaaatcggc gtcaggcgca aagcccattg ttggcatttc ttcatgcttg 2498101 aaataatgct ctacgcatct ccaatcactt tcttcatctg ttccgataat cattctgact 2498161 cgcttggaca ggggcaaatt catgtctttc acgattttca gcgcgtagaa tgccgccatt 2498221 gtcgggcctt tgtcatcaat ggcgcccctt gcataaatcc gtccgttgcg gatttcagct 2498281 gaaaatggat cactcgtcca cccatctccc ggcggcacga cgtcaacatg gcaaagtacg 2498341 ccgataatgt catcgccctc cccccattca atatgacctg cgaagccgtc aagatttttt 2498401 gttgtaaagc cttctttttc tccaagctcc agcaatgaag tcaggctggc atttacccct 2498461 tctccaaacg gtttaccggg tccggcggtt gtttcgtcca tgacactgtt gattctcaaa 2498521 aattcctgtg tatcacgaat taaatcctct ttttttctga tcacttcaac ttcccagttc 2498581 ataatgatcc cctttccgca agaaatgact tgcaaaaacc aaataaaacg aataatatta 2498641 atggtgtttt gttaaaacgt tcgtaattgg aggatactat gtttcatcta aaagagcagc 2498701 aaacatccat aaagcaagaa atcatagcag ggctgacgac ctttttcaca atggtctata 2498761 tcgtcgtggt caatccggtc attctggcta acgccggggt tcctttcgac caggttttca 2498821 ccgcaacgat tattgcctcc attgtcggaa cgctgtggat ggccctggca gcaaattatc 2498881 cgattgctat tgcgcccggc atgggcttga acgcttattt agcctttcat gtcgtaagcg 2498941 caagcgatgg cggcatcacg tacgcaacag ctttcagcgc agtatttaca gcaggggttc 2499001 tcttcattat tctatcgtta acgcctttaa gaaaacaact tatagaagcg attccaaaca 2499061 atttaaaata cgggatcaca acagggatcg ggctgtttat tgcttttatc ggtttgcgtc 2499121 aagcgggaat tgtggcagct gatgagtcaa acctggtcac tctcggcaat ctgcattcac 2499181 ctggtgttat cttaacgctg gtcggccttt tgatcagcgt ggtcctgatg gtgctgaatg 2499241 taagcggcgc tttatttatc ggaatggcag ctaccgcttt gatcgccttt ttcaccggtc 2499301 agctccattt ttcaaaggga tttatgtcgc ttcctcattt gccggaagga ttgatgatct 2499361 caaatccatt taccgctttt ggcgatgtca ttcatcacgg cctgtacgct gtcgtctttt 2499421 cttttctatt agtcaccatt tttgatacga caggcacgat gatcggagtt gccgagcaag 2499481 ccgggctgat gaaaaacaac aagctgccga acgtgcgaaa agcgctgctt gctgattcaa 2499541 ccgcgacgac agtaggagct gttttcggca caagtccgac gactgcattt atcgagtctt 2499601 ccgccggtgt cgcagccggg ggaagaacgg ggcttacggc tttgactgtc gcggtgatgt 2499661 ttgcggcttc aatgtttttc agtccgcttg tcagcgcctt gtcaggtata gccgccatca 2499721 cctcgcctgc tttgattatc gtcggcagcc tgatgatggg ctcagtttcc aatatgaact 2499781 ggaaagagat ggacgaggca tttcctgcgt ttctcgtcat tctagccatg cctttgacct 2499841 cgagcatttc tacaggaatc gcgcttggct ttatttcgta cccaattgta aaagcggcgc 2499901 ggggaaaatg gagagagatt catccgctcg tcatcgtttt cgccattctg tttttcatcc 2499961 agctgtttat tttataagga tagaccaaaa aacccaaacg tcgccgtttg ggttttttat 2500021 gtaaacaata aagagacagc ggccgctaaa aaacaacagg cggcaaacgc atagtgcagg 2500081 atgttgatac agctttttct ggcccgataa tattcatcac tttccttatc ggtgccaatt 2500141 aaaaaagggg catccatgac cttgtcaaaa ataagcgtca ggatataacg gcaaacccct 2500201 gtgtatacca gcagcgcaat caccttcagc caaattgggg aaacaaatat gagaacagtg 2500261 aaagctgaca gtagcatgta catctgcctt gcatactcgc cattcctcag cataacttta 2500321 aaaaacaact ccttatagcc tgtgcagatc gttcgtcttt taaatatcct ttttgaattt 2500381 cggtataata atggttttct tctcatcctg tcttttactt ttggcattcc cgcctcctga 2500441 ctcatcatca tcacaagtcc tgcaagggca agcctgcttt ttttctcttc agtcacctca 2500501 gcttcaaaag ccgtgaacga ggctgtcttt ttcaaactgc ggataactga gaaaaacaaa 2500561 aataaaatgc caaaaagcgc aagcaagtgc cgctcagtaa aaacaatcag gatagcagaa 2500621 ccagcaaaaa gaatagctct gacaagggta tcgccaatcc atctcgaaat ggagcgcggc 2500681 tttctgatcc tgtcttgctt taaggataaa aagaatatat gaaggccaaa caaataacac 2500741 aatagagcag tgctttctgc gaatgtgatg agaacagaat gactgatcaa gggaaggaca 2500801 atgaaaaaga gaagcagcca tttagccagc gtggccagaa aagaatacaa aagcgcatac 2500861 cgtttgagct gatagatgat ttccttcttt tgcagcaaaa acactttgtc cgcttccatt 2500921 aaaaatgtac gaatcgaacc tgtaaacatg atcagcacac acacagcata cagccatctc 2500981 cattccgcca cttcagacca ctcataaaga aggcctcttc cgttcatcaa atcaatatac 2501041 tgatagatga caaaagcaat cgccggcaaa acgatataga gagcgactgt ccagtcaatg 2501101 accgcatgca acactttaaa ctgatactta taatagtcaa acagccttcg aaaaaagagc 2501161 gtacgcccgt tcatagccga tcaccttgaa ctgccttata aaaacagtca agcaatgact 2501221 gcccctctaa tccggtcttg tcctgaacat cttttaacgt gccttggaga aataatgaac 2501281 ctttctcaat catataaaac cggtcacaga ttttttccgc ggtatcgagt acatgcgtgc 2501341 acataagaat tccggctcca cgttcttttt cagccttaag catgtccaca aagcgtttcg 2501401 tcgatatcgg atcaaggccg ataaacggtt catcaatcac atacatatcc ggcttagaga 2501461 gaaaggcctg gataagcatt agtttttgct gcatgccctt cgaaaaggtg acaggcagct 2501521 catgtttgac atgatctagc gaaaacgtct gcagcaggct ttgggcccga tgcgcaaatt 2501581 cactctcttc aatgccgtga agtgtgctga tcagatccaa atgctcccac agcgtcagtt 2501641 cttcgtagaa ggacggatgc tccggaatat atgcaaatga acagtcgttc caggcaatat 2501701 gccctttaaa atcttctgaa aggccgagta tcgccttgat tgcggtgctt tttcctgcgc 2501761 cgttagctcc gatcagtcca accagttccc cttttctgac ttccagaaaa acatcggtga 2501821 gcactttttt tcggcttgta tacccggcct gttctattga agcttcaagc aaatttgtca 2501881 aaactcactc acctccaaaa tttactacga aatagaataa aaaaagtttc tttaaccata 2501941 ataatattga gccgaaatac atagtaatcc aacaaggatg gctgcccaac gcgaaattgg 2502001 aaaaaattaa taggagttat ccctagattc atcactgcaa tatcgtgtat aatgagggcg 2502061 aattatttta acaattacag atgtctgcct ttgttgctat ttcgtacgca gttgatagtc 2502121 gtgagttgtg gttagtcaag tccatccgat cttatgatag ggagtggttt tttgaaacct 2502181 tcaacaaacc gtatgctaac tcgaatcaaa tcagtttaca tgtttattca agaaaaaggt 2502241 cttgtgacaa cacaggaact ggttgacgaa ttcggcatta cacctagaac gattcaaaga 2502301 gacttaaatg tgttggcata taatgatctt gttcatagtc caagccgtgg caagtgggag 2502361 acaacgagaa agaaagtaaa gattacctca taaattgaaa attacatagg gccgcctgag 2502421 agcggtccga tagataacag ggcgaagaaa ctactgagcc ttgtttttgt gtgcttataa 2502481 ataaaacccc gcattcggta tgcggggttt ttgtcatgct tgcggctcat ttagcaaatg 2502541 aagctcttcc tctgtcagct cacggtattc tccgggtgcc agagcgggat ctagggaaac 2502601 gcgtcccatc gaaagccgct tcagataaac cacttcattg ccgactgcct ttgccatttg 2502661 cttgacctga tggtattttc cttctgtaat tgtcagatat ataacggtat tgccactgtc 2502721 gtttgttttg atttccgctt ttgccggctt tgttttatag ccgccctcta tgtagacacc 2502781 cgtttccaaa tcggaaatgt cttcccgaga aatctgtgat tttaaatgga cttcatacgt 2502841 ttttggaaca tgctttttag gagaaaggag ccgatgtgcg agctggccgt catttgtgag 2502901 cagcaaaaag ccctctgtat ctttatcaag cctgccggct ggaaatggct caaatctcat 2502961 ctcctccggc gtcagcagat cgaccactgt ttgctgccgg ctgtcctcag tcgccgacag 2503021 cacgccctgc ggtttattca tcataagata aatgaactct cgataatcaa ccggttcccc 2503081 gtatacggtc acctcctgcg tatcaggatc aacgtgctcc tttacatctt tggcaggttt 2503141 gccgtcgatc atcacggctc cagccttcac aacggctttg acttcttttc tggaaccata 2503201 cccgctgttg gcaagcagct tatcaagtct cattcccaat ctctccttta taaaagaaag 2503261 cccgcagcat gcgagccctc agtttcatca tatctagttc atcagcctgc atgtctgcct 2503321 ttcctaaaga aacctggcaa acggcggcct aaaattttct gcaaaaatcc taatcggtag 2503381 ccgcaataca ggtagacagc tccgccaaca gcggccgcga tcaccacaac aatcgcagct 2503441 tgcatctggc catcctgata ggaaataaag aagcctaata cccactgcac gattttcacg 2503501 gcaataccca taatggctga taagaccagc atcaaaacag ttcgtttaac aagtatctta 2503561 tacgaatagc ctgcatggcg cttaatcatg ataaacccat ataaaaggga agcgatatat 2503621 ccaagcgccg tcgctaaaat cgctccgtca gcctgcatca gcttgatcag cggaacattc 2503681 agcacaagct tgatcacgac accgatcaca aggctgacaa ccgcaaattt ttgcttattg 2503741 atgccctgca gaatagctgc gttgactgta aacaaagaga acagaattgc gacaggcgaa 2503801 taccaaagca aaatgtttgc ccccagttca ggatgaaggc tctctgaccc gtaaaagaac 2503861 gtatacgtcg gtcctgacaa tagagagatc ccgacaacag ccggaataat taaaaacagg 2503921 atcgtctgca tcgtttgatt aatctgctga tttaacagct tatagtttcc gcttgtaaac 2503981 gattcagtaa tcgttggaat taatgtcagt ccaaaagcag ttgctaggga aaccgggatc 2504041 atcacgagct tctgaacata cagggttaga atcgcaagca tgtcctggct gatggcttga 2504101 tgaccggctt caatcatcgc tttgttaaac gtatttgtat caatatagtt atacaaaggg 2504161 atggctagtc cgacaaaaac gtacggagca gcatagctga acagctcgaa aaacattttc 2504221 ttgtagctta ggtttgctgt cggacccgta ttcggcatca tcgccagcag gctgcccttc 2504281 cgtttgttcc aataaatata aagcacgacc agccctccga aggcaccgat cagcgctgcg 2504341 aaggttgcat agcccacagc gatgacaagg ccgccgttga aaaccttcaa aatcaagaat 2504401 gtcgcactca atagaaagat gatgcggaca atctgttcaa cgacttggga aacagctgtc 2504461 ggacccatca tttggtgccc ttgaaagaat ccgcggacaa ggctcataat cggtacgacc 2504521 aaaagcgcta agctgaccat gcggatgaca taaacgacat gatcaattgt caggccgtta 2504581 ttatccttgc ctcccagcga tatttccgca aacatcggag ccgatagata cagaatgaaa 2504641 aaggctatca ttcctgtgac tagcataacc gacatgcccg ccttgagcat tttcctgctt 2504701 gtctcataat ccccttttga attatatttg gaaacaaatt tagaaacagc ggccggaaag 2504761 cccatcgtag caatattcaa aaataaagtg tattggttgt atccgtattg aaataatgca 2504821 ccgcctgtcg ccccgaccat aatgctgaag ggaattaaat agaccatccc cagaatccgc 2504881 gatatatatg taccgagcgt taatacaaac gtgcctctta acagtttgct tgacatgttt 2504941 cttcatcacc attttctacg aagattcaac ttttctattt taccacaact gggcatttag 2505001 acggtaataa atacaaaagc aatcctgtga acattcatgt ccgcggcaaa agacgtttaa 2505061 ggagcggctt tctttcgcta taatagtact gcggacgggt gtccgcacac gaaatgaaaa 2505121 gaaagttgat gataaagatg aaacaatatg acgtaatcgt aatcggcgga ggcccttcag 2505181 gcttgatggc tgcgattgca gcaggagaac agggcgctgg cgtgttgctg atagataaag 2505241 gaaataaatt aggacggaaa ctcgcgattt ccgggggcgg ccgctgcaat gtgacgaacc 2505301 gccttcctgt ggaagaaatt atcaagcaca tccccggcaa cgggcgtttt ttatacagcg 2505361 cgttttctga atttaataat gaggacatta tcaagttttt tgaaaacctc ggcattcaat 2505421 tgaaggaaga ggatcacggc cggatgtttc ctgtgaccga caaagcccaa agtgtcgttg 2505481 acgcgctgtt aaacaggcta aagcagctcc gcgtaacaat cagaacgaac gagaaaatta 2505541 aatctgtttt atatgaagat ggacaggcag cagggattgt gacgaataat ggcgaaatga 2505601 tccatagcca ggcagtcatt attgctgtcg gcggtaaaag cgtgcctcat accggaagca 2505661 cgggagacgg ctatgaatgg gctgaagccg cgggccatac cataacagag ctgtttccga 2505721 cagaggttcc cgtcacttct ggcgaaccgt tcattaagca aaaaacactt cagggcttat 2505781 cactaagaga tgtagccgtc agtgtgttaa ataaaaaagg caaaccgatt atcacacata 2505841 aaatggacat gctgtttacc catttcggcc tctcaggacc tgccattctc agatgcagcc 2505901 aatttgtcgt aaaagagctg aaaaaacagc ctcaagtgcc gatcagaatc gacttgtatc 2505961 cggatatcaa tgaagaaacg cttttccaaa agatgtataa agaactgaag gaagcaccga 2506021 aaaaaaccat taaaaacgtg ctgaagcctt ggatgcagga gcgctatctc ctattcctgc 2506081 tcgaaaaaaa cggcatctct ccgaacgtat cgttttctga gctgccgaag gatcctttca 2506141 gacaatttgt aagggactgc aagcagttta ctgtcctcgc aaatggcaca ctgtcgcttg 2506201 ataaggcatt tgtcacggga ggcggggtat ctgtaaaaga aattgacccg aaaaagatgg 2506261 cttctaaaaa aatggagggg ctttattttt gcggtgaaat tctggatatc cacggctaca 2506321 caggcggata caatattacc tccgcccttg tcacaggcag gcttgcaggg ctaaatgccg 2506381 ggcaatacgc ccgttcttaa tcattactct ttaaatctct tgccgccaaa ctcacatttg 2506441 aacattcccc gcattcatgt tagggtgaga cttgttttgt ttcacctgat tgcggggtaa 2506501 ttttaagaga ggaatgagct gccatcgtac gaccatacta agcctgcgag caagatatag 2506561 gcgtacacaa aaaattagag ggtgagaaat gttgaaacat atatctagtg tattttggat 2506621 tgtgattgca atcacagctg cagctgtatt atggggtgtt atttctcctg acagcctgca 2506681 aaatgtgtct caatcggcac aagcatttat taccgattca tttggttggt attatctttt 2506741 agttgtctct ttgtttgtcg ggttttgtct ctttttgatt ttcagcccga tcggaaaaat 2506801 caaactcgga aagcctgatg aaaaaccgga attcgggtta ttatcatggt ttgccatgct 2506861 gttcagcgca ggcatgggaa tcggcttagt attctacggt gcggctgaac cgatcagcca 2506921 ttacgcaatt agctctccat caggtgaaac agaaaccccc caagccttca gagatgcact 2506981 ccgctatacg tttttccact ggggtttgca cgcttgggcc atttatgcca ttgtggcatt 2507041 atgcattgcc tatttccaat tccgcaaagg cgcacccggg ttaatcagca gcacactgtc 2507101 accgattctc ggggataaag taaacggacc gatcggaaag gccattgact gtattgcagt 2507161 tttcgccact gttgtcgggg tgtcaacaag tcttggtctt ggcgcaaccc aaattaacgg 2507221 cggtttgaat tacctgttcg gcattccgaa tgcgtttatc gtccaattgg ttttaatcat 2507281 tattgtgaca gtgctctttt tactttctgc gtggagcgga ctcggaaaag gaattaagta 2507341 tttaagcaac acaaacatgg tattggccgg attgttaatg ttgtttatgc tcgttgtcgg 2507401 gcctacagtg ctgataatga actcatttac agattctatc ggacaataca ttcaaaatat 2507461 cgttcaaatg agcttcagac tgacaccgaa cgatcctgaa aaacgcgaat ggattaacag 2507521 ctggacgatt ttctattggg catggtggat ttcctggtct ccatttgtcg gcattttcat 2507581 cgcccgtgta tccagaggcc ggacgatccg cgaattttta atcggcgtct tggtgacacc 2507641 ttgtattttg acatttctat ggttctccat tttcggcgta tcagccatgg atctccagca 2507701 aaaaggcgcg ttcaatgtag caaagctgtc cactgaaacg atgctgttcg gaacacttga 2507761 tcactatccg ctgacaatgg tgacatcgat ccttgcattg attctgatcg cagtattctt 2507821 tatcacgtca gctgattcag ctacattcgt gctgggcatg cagacgtcgt acggttcttt 2507881 aaatccggcg aattctgtga aactcagctg gggtatcatt cagtccgcca tggcggctgt 2507941 gctcctatat tccggagggc ttgccgcttt gcagaacaca gcgattctgg cagcgctgcc 2508001 gttttctatc gttatcctgc tgatgattgc ctctctctat caatcgctct caaaagaaag 2508061 aagagagatc aaaaaagcgg agaaactcga taaaccaaga agtccaagag tgaaaaaagc 2508121 atattaacaa aaaagatctt tccgcgcctg cggaaagatc tttttatttg cgatataaaa 2508181 taagggcgga aaaacagtaa agctgctcgc cgtctgggtc gcacgccgcc gaaaccgtat 2508241 atttgatatc tatcagctgc tcctccgata tcccttttaa aaatgaattg atttccgttt 2508301 gtaagtcttt ttcatgctct tcatcaaata ccgctacctt cagcatttta tccgctctcc 2508361 tttctctatc aatctattcc gtttggaaca gcgttatgat agagaaatga tgattatctc 2508421 gtttccggat aaaaagcttt ccgtatatgg gatttcctct gtggctcgcc gccgtgctgc 2508481 tccactttca gcagcacggc ataaacaatg cgcatatggc agtagctgat aaggctgacg 2508541 ctgaaaaaag ggacaatgcc cggcaggtac gcaagcaaga aaaagagagc aacagtcagc 2508601 gcaagcatag taagcgtata ttgcaaatac gccacactga gcaagagcga aaatttcaca 2508661 tacagacgtt ttttccagtc aaaatggaca agcagcggaa acacataaaa aagcatggat 2508721 acgaacaaaa agccaaatat cataatggcg aagcgcagga tgtgcagaag gaaatgactt 2508781 ggataaatta aggccaaatc aatataaatg atcactccga tgagcgccag tacagcgccg 2508841 agcagatttg aacgaaaaaa ttcacccttg tattcctgcc aaaacgtttt gagcaccgga 2508901 acgttgtcct gcccctggat ccacttccgc atgacagcga ataaagccgc ggtcgcgggc 2508961 atgatgccaa acacgccgag accgagcaac gtaaaaaaca gccacagcaa gtttgtatac 2509021 gcaaatctca taatccattc gcaaaaacgc agcatccgtc ccagtgagcc atcatgttcc 2509081 atggcgcccc ctcctttttt gcattataca ttctgcatct gaaaaagctc tttcatgccg 2509141 atcggcttct tttcggcaac cgagcgccac attccctcac caaccgcgat ggagtaggct 2509201 ccagcttcag ccccggctaa aatatcatag cggcgcagcg ggtctttccc taaaaaaaga 2509261 tcctcaagca aaagcggatc acctccgcca tgcccccctt catttttgac cacttgtatc 2509321 gtctgctttg attcaaaaag cggatagtat tcgattgtct gctcaggaaa agcaaacgga 2509381 attctggaag gttcgtgaaa ttcatttgat tcaatacgtc cttttgtgcc gttgatcgtc 2509441 agccggtagc cttcatacgg ggccgaaaaa ataatcgagt agcttaacag tgcgccgcca 2509501 tcatatttga ctgccgccac gtacgtatcc tcgatgtcaa tttcctcgtc aaaaatacac 2509561 gcgtcaggcc tgtatgcagt atataagctg gactggtctc ctgcttcaag atgatcatcc 2509621 tttatagaag ctttagagga acggggatgc caccttgaat agtagtggca tttttcttta 2509681 acacggcacg tcccgcaaaa acgcccgtct tcttccggca aggggttcca ctcactgtcc 2509741 ggcccatagt aattcaaggc gccataagca aatacctctt ccggattttg cccgagccac 2509801 caattgacga gatcgaagtg atgtgttgat ttatggacag aaagaccgcc ggaaaactgt 2509861 ctcgacctgt tccagcgttt aaaatagctg gcgccatgat acgtatcaat ataccaattt 2509921 aaatcaacag aagtgaccct gcctattttt ccgtccagaa tcatttcttt tattttccga 2509981 tgaaacgggc tgtagcgata gttaaacgcg acggtgactt ttccttcgct tttggcctcc 2510041 gcttcaagca cccgattcgc atcctgcact gttgtcacca ttggtttttc agtaatcaca 2510101 tctgtattcc actgaaggct ttttacaata tatgcgacat gcgtatcgtc cctgcctgcc 2510161 acaatgacga tatcaggctt tgagacgcgc atcatctcgt caaaagcatc ttcgctaaac 2510221 tcaggcacgt gggccagctc gggaaatttc ttcttgcaaa cggcaaaacg tttcggatcg 2510281 gcatccagca atcccgtaat ctcataatga gttgaaaacc gctccatcag tggtttgata 2510341 aacatactga atgctctgct gctcaatccg caaaagacga tgttcttcaa tatcctcacc 2510401 tctatcgggc ttcagttagt tgagaaatca gctgcagcgc ttcctctgtt ttttcagcat 2510461 acacagggat aaacgccgcc atatcgcgat tcaattgaaa agaatagccg ttcagctgtt 2510521 ttttcccttt ttcgatctga acggcataga tcgttttttc tcctgttttt ttattaacag 2510581 ttgtataagg agatgttttt tcaggaggca atccgtttaa cggctgaaaa ttttccggat 2510641 catcgtaagc ttgaaacatg tcttcaggca cgatgaaaac atctccctca tgggcggtaa 2510701 tttcagtcag cagtttttcc tgaaaagctg gaaagatatc gaccttcccg gcattctgct 2510761 cggcggcctt ttttattttt tcctgtacgc cagcctgcat atcagaaaag agaatgacat 2510821 gcattccgtc cggcctgctt gagcatgatg ccaaaaagag cactgagacg atcacacaca 2510881 aagccgtacg tatccttttt gtcatttccc cgctgaccta aaaagaggct ccagctctgt 2510941 catagctaaa ataaacgcgc cggctccgtg cagatcgttt gtgcttcttt cgcggctgac 2511001 ataatagtca tagaaaccgg ctgacgttcc gacacatatg tctttgacga gaaacgctcc 2511061 gtcttctgat gtttcggttt tatgctgaat caagccttga tacgctttta gcagtgttgt 2511121 ttcgtaagct ctgtctagat agcctttatt gattcctttt gcgattgcgt acatgtacag 2511181 acaggatcct gagctttcca gccagttatc agacctgtct cccttatcaa cgatctggta 2511241 ccataacccc gtctctttgt cttgatagcg acagatgctt ttaatcatgt cctgcagcgt 2511301 gtttttccac acatgacggt tcggatgctt cttcggcagc tcttcaatca tgtcagcaag 2511361 agacatgacg taccagccga tggaacgtgc ccaaaattcc ggtgaacagc ctgtctcttc 2511421 attggcccaa ggcatttttt tcgcttcatc ccaggcgtga taaaaaagtc cggtttttgc 2511481 atccttcgta tgctttctca tcaatgactc ctgaagcaca acctgatcaa acagctccgt 2511541 ctcctgcttc agattggcat atttcagtgc aaacggcccc cccatgtata agccgtcaag 2511601 ccacatttgg taaggataac cgtctttgtg ccaaaaaccg ccctcagacg tccggttcag 2511661 tgttccatat aagctgcgca gcctttttgc cgctttgaca taccgttcat ccttcgtctg 2511721 ctcgtataat ggaaaaagaa tgagacctgc ttgaatggcg tccagttcat ctcttctaaa 2511781 taatagattg ccattatcat cgattaagag atctgcataa gccttcgcat actcaaaata 2511841 ccgcttttcc ccggttgctt cccacagccg caatacaccg cataagaaaa caccctgatg 2511901 gtagtgccag cggtttgcag gtggcagctc ctcgactgtg tacgtgttca taatggtgtt 2511961 tgccaatgcc tccgcgtacg taagaggcga ttttacagcg attgattgat ccattgatcc 2512021 catccctttc ctaataaatt ccttcctcgc caaatttctt cgccaaacga ttcgctagca 2512081 tgaccaaaat cagcccgacc gccgctttaa atacgccgac tgctgtactg tagctgaatt 2512141 ggccctgttt cagccctgca gtataaacat acgtatcaaa aatttccgcc acttccctgt 2512201 tagtcgcatt taacagcaaa tacacatgct cgaagccaag ctccagcgtg tctccgattt 2512261 tcaaaatcag caaaacgacg ataacgcttt taatggcggg cagcgtaata tgccacattt 2512321 gccgcagccg tcccgctccg tccattttcg ccgcttcata cagctggggg tcaaccgctg 2512381 taatggccgc cagataaatg atcgtcgacc agcccgcttc cctccagata acctgcagaa 2512441 tatacagggg ccggaaccat tcttcgttca gcagaaaatt gattttttca ccgccaaaaa 2512501 acacaatcag ttcattaatc aagcctccgt ctaccgttaa aagcacaaac gaaagcgata 2512561 caacaatgac ccaagacata aaatgcggga tataaatcag cgtctgaaca aattttttaa 2512621 agagagcaat ccgcacttcg ttcaatagaa gcgccagcag tatcggcacc gggaaaaata 2512681 tggccaggtt caaagcaaat aacacgagcg tgttttttaa caagagaaaa aatgtaggct 2512741 cagtaaacag cctgataaaa tgcttcagcc ccacccactc actgcccaaa atgccgagga 2512801 acggctgata atcctgaaac gcaatcacaa ttccccacat cgggacatac ttaaaaagca 2512861 aaaaataaat acaccccggc aaaatcatca agtacaaata tttttgttga atcagcttga 2512921 ttagtaagcg ctttcttttt tcttttttaa aaatgactgc atcaacagcc ggcgcttgcg 2512981 cttctgctgt tttcattttt tcctagcctc ctttcacgga ttcttgcatt cactgtagcg 2513041 cagcaggcaa aagtccgtct acaatcatat gatcacatcc tgttttatcc ctttataatc 2513101 aagggttcag ccggtccacc tgaaaaaaag acaccgatat tagaaaatga ttattgacaa 2513161 tatctatcaa tctttggatt aattgtatta aggtgaagtg gatgttatga aatggggggt 2513221 tttatgaaaa gaagccaata caagttttac tacaaactga tcacgttttt ctgcctgctc 2513281 agcaccattc cggttatttt ggtcggatta ttttcgtacg agcactctca gaaaacggct 2513341 atttccaacg tttcggagga aaaattcgac acactccagc agacccagca aagcatcgag 2513401 catatattga aaaccgtcga tcactcttta acccactatg tgagttcgcc gcctctcctt 2513461 cgcacattgt ccgagccttt gcactcagac caatttcaaa tctataacca agtgaaccaa 2513521 gagctcaatt atctgcaaag ctttgatacc gatctgtcca acatgacgtt agtcagttat 2513581 acgaaaaaat ggtacatgaa caattccggt ttgtaccgtt tgaatacaga cactcttcat 2513641 gaagcagcct cagcgtacac gaaacaaaaa gcgagccgct cctattggac gcttgaggaa 2513701 aacaatcatt tgatttcaac caaagaaggc acagcagaaa actgccgcta caatatcaat 2513761 ttaattaagc agcttccttt gaacagcaca aatacaaagg gattggccgc cgcaagcatc 2513821 ccgagctgtt cgcttgtcaa aaatatgccc ggctattcaa acgccaacaa cctgtttatc 2513881 atcgatgaaa aaggcctcat catccttcat aacaatatgt ctgacgttgg tgaatctctt 2513941 cataacgacg gctttgtcca aaaagtgctg gcgcaaacgg ccaatagcgg acagtttgaa 2514001 acagtgattg accggattca ttataaagtc acctatcaaa aatctgacta taatgcatgg 2514061 acttattttt ctctcgtttc cctgcctgag ttaaaaaaag aagccaaatc aatcggctgg 2514121 atcacttttg cagtatgcct cattttgtta acgctttcat tgctgttctc ttggcttggc 2514181 tcccgccatt tttacaagcc gatcagggtg ctttacgaat cattcgcaag acatggagcc 2514241 atacaagaga aacaacagcc tcctcaaaat gaatttgagt taattgaaca gagctttaag 2514301 cagctgaagg acagaaatga cgaccttgaa gaaacgatga agcagcaggc cactcatctg 2514361 cagcaatatt ttatggtcag gcttatgctt ggaaaactga cggatgagga ggttgataac 2514421 cgttttgaaa gcctcggctt aaagcaaaat tggcggcacc ttgccctgct tgtgctccaa 2514481 attgacacac tgaatcatac gccttatgag aaaaaagata tggatctgct tttgtttgcc 2514541 gtcaacagcc tgattgagcg caacatcccg acggacaaac atcttgcccc cgccgtagtt 2514601 gacaaacagc aggcgacgat tttgatcaat caaagcggga caaaggaaga attcatggct 2514661 gagctgaatg agactgcaag gatgattcag gaaaaagcgg aagctgagct gcagctgtct 2514721 gtcagcatcg gcatcagcca gccgtttgat gtgctgacaa aagcgaaaac agcctatgcg 2514781 gaaggctcag aagcgttgaa atatcggctg aaagcggaaa acaagtcgat catcttttac 2514841 gaagaccttg accagaaaaa aaccttcaaa acccattttc caaagcagct tcagcatgag 2514901 ctgttcgatg ctgtcaaagc aggagacaag gagaaagcgg ataaatgcct gcacgcgatt 2514961 ttacaagcca ttttcaccca gaacaccaac ccgtatcaat ttcaaatcgc catcgcccgt 2515021 tttttgaacc atgtgattga gctgatgcat gtgcttggga tcgaattgtt tgagcttgaa 2515081 gaaaacaaaa tgctgtatga ccaaattttt gagctgaaaa cgttcgagga taccgaaaac 2515141 tggctaaaga atgagtttat tgatccgatg acagacaaag tgaacgcccg cgcggatgcc 2515201 cagtacaaaa atatttccga caacatcatt catatcatcc atcatgagtt tgaatccgaa 2515261 ttgacactgg acgaaatcgc acgcaggctg cattacaacc caaattattt aagcagtatt 2515321 ttcaaaaaag aaatgggaat ttcattcagc gagtatgtct caagctaccg acaccatatg 2515381 gcgaaaagct ggcttgccga aaccgacatg gcggtcaagg acattgccga aaagctgaaa 2515441 tataaaaact cccaaaactt catcagatca tttaagaagc tggaagggat tacaccggga 2515501 aactaccgcc agcaaaaaag aagcatgtaa aaaacccaaa accgcttgcg cgttttgggt 2515561 ttttccaatg ttattttgct tgtttaaacg cttcttcgta ttcctgaata atttgttttc 2515621 ctccgcttga ctcccatttt tccacttctt tatcgaactg gctttctgtg atgtctccaa 2515681 tcatatattt gtaggtcgcg tcatcaatga ttttcttcag ttcgtcaccc cgttccgact 2515741 ccgatgcgga atacaggctt tcagccgggt ttgagacgat aatcttttca ttgtcctcgg 2515801 tcagctcctc gtacgccgtc cgaagcggat ctccagtgtt ttttaagtag gctttatcaa 2515861 tggcaattaa agcggacagc ggctgaatat cagtctgcca gtcttttacc tggctttctt 2515921 tgcgtgtaaa cgttttgtcc tcacctttgt tgtaatgaac gccgtcaatg ccataagtca 2515981 tcaggctata gacatcttct tcggcaattc ggtcaaaaaa cgccaagatc cgtttaagct 2516041 cagcttccgt tttcacactc gttttcggga aagcaaacac gccgttatgg cctcctgatg 2516101 cccatacccg ctctttccca tctgggcctt ttatgcggtt gatgatctcg agcttcatcg 2516161 atttatcaga ggcatggtcg cgcagattga ccgcatctac catattgcca atataaattc 2516221 cggcttttcc ttgagaaaac agctcttgct gctgggtttt gcttgtgacg ggaaaatcct 2516281 tattcatata cccgttatca cgcagctttt tcatatagtt catcgtgtct ttgtattcct 2516341 gtgtcatgaa atcaggcgtg aatttgccgc ccgattcctt ccaatctgtc ggcatgcctt 2516401 catacgagcc aatcgtttta aacgcgccgt aaatcaagtc attacggtct gccagcccga 2516461 atgtatcatc tttcccatcc ttgtccgggt cgtcctccgt aaatgctttg gccacttcat 2516521 aaagctcatc caacgttttc ggggttttca aatttaaatt gtccagccag tccttccgaa 2516581 tgacgatccc ctgtctggaa agcgggcgct ctctgtatat cccgtagagc ttgccgtcaa 2516641 ttgtcacatt tttattaatg agtttgttca ttttgtttaa gttgggataa tccttgatat 2516701 aatcgccgat ttcccaaaac attcctgacc gaaaggcatt catgactgac gaatttttaa 2516761 tatcctggat ggtcacgatt tgcggaagat tgccggctgc aagcgctgca ttcagcctgt 2516821 cttctttcac cgcgtctgga acccaggtga tgtcgagttc tgtatttgtc agcttttcaa 2516881 tttctttaat cgccctgtct ttcggcggct gctggtgata caaaatcgcc atccaagaca 2516941 gctttacctt tgaatctggg ccagctttgc cttcagccga agactgatca gttcctttac 2517001 agcccgccag cactccgccg agtgccagta caagcacaat caaaagcacc ctccatttgt 2517061 ttcccatcgt acccctccgt ttcatatttc tttatccttt gacagatccc agcaaagctc 2517121 cttttgcaaa atgcttttgt ataaacggat agacaagcag aacagggatg gtcgccacca 2517181 ctatgaccgc cattttaatg gtttgctcag gcggcgggct gcccgacccc atttcagaca 2517241 tatccccctg cataccgctt gatacaatga cgatttggcg cagaagcacc tgaattggcc 2517301 attttgctga atcatttaag tacaagatcg ctgtcatata cgtgttccaa tacgtgaccg 2517361 cataaaatag tgaaatcgtt gcgatcgcag gaagagacag cggcagcaca attttaaaga 2517421 atatgcccag atcattgcac ccgtcaattt tcgcggactc ttccaggctt gacgggatat 2517481 tttgaaagaa gtttttcaga atgatcaggt taaaggcatt aatggctgtc ggcaaaataa 2517541 gcgcccagta agaatcgagc aatccaagcg atttgaccac aaggaaagtc ggaatcatgc 2517601 cgccgctaaa cagcatcgta aatacgacga gaaacatgag cggctgccgg ccgattaaat 2517661 cacggcggga taacccgtaa gccatcagtg acgaaagaaa catgctgacc gcagtgccta 2517721 tcactgtcac aaacacagaa acaagcaaac tcttataaat aatatctgtt gaaaaaatgt 2517781 agcgataagc atctagcgaa aaagtggtcg gtattaaaat aaattttttc gacacgactt 2517841 cttctactgt ggcaaaggat gctgcgataa catgaatgaa cggaagtacg catattaaag 2517901 cgaacatcag caagaaacca taaatcaaca tatcaaacag acggtttttc agtgaatgtg 2517961 cgatagctcc cacctccctt tgtaagcgtt atcatatttt tggaaaccga gctcagcatg 2518021 tgacgatatc gtgtctaaaa tgtagcaaat ctgtgattgc catgtctata atcatttgaa 2518081 cagtgtcccc ggccgggcgg gggctgccgc gaattgagac cgataacaaa agaaaaagag 2518141 cataatctta gaaaatgatt atgctccgtt ctcctcctcg ttcagaagtt cagccgtatt 2518201 gatttgtggc gaaaacccaa gttcattcac ggcagattca atggaccatg gccggcccgg 2518261 attatcagag acggcgtaat aagtgccata ccggatgttg gtctcaatgg cggctttgaa 2518321 aatcgacagc agatcggggt gagaaagcag tgtctttttc gtccgttctt tttcatgcag 2518381 cgtatccatt tcatctgtca cgactgttcc gattcgaagg ttgattactg atagcttatt 2518441 ttccaaataa aacaaatggc cgatctgttc agaggtcagc tttaatacac cgtacaagtt 2518501 ttttgacagc ggataatcgc ttgttgtgat ttcccgtcct aagagcgagc gcccgtcttt 2518561 ttcatataca tctgtgacat gattgctgct ggcgaacacg agcttttgaa tgccgagctc 2518621 cgctgccgca cggcacagat aatagcttgc cctatagaaa acatccgtca ttttttcaaa 2518681 ctcagcgatg tccataatat cgtatttgat tttcacagcg agtaaattca agatggcatc 2518741 ggtatctttt ggaatcttct tcaacagctc ctcataattt gccgcgtcag cctgaatgga 2518801 agaggctttg ccatcgaaat gatctttatc aagcacagtc acttcatagt ctgaaataag 2518861 cccttcagca agcagtctcc caatcacacc atttccgccg gcgatcagca cttttttcac 2518921 gatgttcact cccctttttt atagattgcc cattttcggc ggggctgaca cttttttggc 2518981 actcacattc ttaggcttat tcaaaagtca ccggcagctc ctcaagcgcc cgaaatccaa 2519041 aaagcggccg ataccgccat tcaaaatccg caagattaag gctgggcatt cgctgcagaa 2519101 gagtgttaat cgcaatttgc gcttctaatc gtgccagcga ggaccctaag caaacatgat 2519161 ggccatgccc gaatgaaaga tgcggattag gacttctcgt aatatcgaag acatcggggt 2519221 tcgtgaatat gctagggtct cgattagccg ctcctaacaa aagatagact tgttctcctt 2519281 gacggatcgt caccccgcag atgtcaatat cctctgacgc aactctggct gtcatttgcg 2519341 tggggctttc atagcgtaaa cattcctcga ctgcggtacc aataagatct ggattttctc 2519401 tcagtttcaa aagctgttct ggatgctgca gcagacaaag gactgaattg ctgatgagat 2519461 tgaccgttgt ctcatgtccg gcgatcgcca gcaatatgca cgtagatgcc gcctcctctt 2519521 ccgtcagctt atccttttct ctccccttca agagcatgct gatcatatcc tgttgagggt 2519581 ggcgttttct cttttgaatc agctctttga aatatgccat agcctgcaca gccataatat 2519641 tgccctctgt taatgccttt cttgagcggg taaaatcaat cgtttgaatg agactcgcag 2519701 cccactcctt taattgctcc ctatcttcct ccggtacacc tataatgtta gctatgacaa 2519761 aacttgctaa aggaaaagca aagtccgaaa tgacctccat ctttttttta ccttgcactt 2519821 gatcaagcaa atgatggaca gtttcaatga tatacggctg ataactctct gtcgttctcg 2519881 gcgtaaacgc tccgctggca agcgtccgca atcgtctatg atcaggctgg ttctgaaaca 2519941 gcatcatttg attttgcaca tgtgaaaggt cctgatattt ggttgagctc tcaggcagcg 2520001 gggtgcggac tttgaatctc gcatctttca aaatagcagc cgtttcttca tatcctgtga 2520061 cataccagcc cgggtatttt aagaaactcc ctttatagat aggatgaaca gctcgcaatg 2520121 tgtcgtaaaa agaatatggg tttttcaaaa actcagaaga tgcagttgac gatgcaattg 2520181 tcacgtgatt ttctcctttc tgttcaaaaa taaaaacaat cgacatcata ccgattgctt 2520241 ttattgattc tttcagcttt tcgcacttaa actagccttc atttcttcga ctgattcaac 2520301 ttcaaagcct aaatcactca gcattttatg atcctccgtc tcctcttgcc cggcagttgt 2520361 taagtagtct ccgacaaaaa tggagtttgc ggcgtaaagc cctaatggct gcaatgtgcg 2520421 gagattgacc tctcttcctc cggaaatgcg aatttctttt gatggattga taaaacggaa 2520481 cagcgccagc acttttaaac aatacagcgg gtttaattcg ttgacgcctt ctaacggcgt 2520541 gccatcaatt gcatgcaaaa aattcacagg aatggaatcc gcgtcaagag ccttcaagct 2520601 tttggcgatg tcaatgacat cctgtttcgt ctccttcatc ccgataatgg cgcctgaaca 2520661 cggagacagc cccgattctt ttgcgatttc aaccgtattg actctgtcat cgtatgtatg 2520721 tgaggttgtg atgtttgaat ggtttctctg tgacgtattc aaattatgat tatagcggtc 2520781 tactcctgca tctttgagcc gcttcgcctg ctctggcttc aacagtccaa gacatgcaca 2520841 aatcttcagt ccatacgtct ctttaatttc ctgaaccgca tctacgacct gatccacttc 2520901 tctgttagac ggacctctgc cgcttgccac gatacaatat gtgccgatat tcagatcgtg 2520961 cgcccgcttc gcgccttcaa gcagcgtttc cttattcacc atccggtaag actcaatcgg 2521021 cgctttcgaa atcgcagact gtgaacaata gccgcagttt tccgggcaga gcccggattt 2521081 cgcattcata atcatattga gctttacttt ttttccgtaa aagtgttttc tgatgtgaaa 2521141 agccccgtgc attaatagca aaatatcttc atcaggacaa tgtaatattg aaagcgcctc 2521201 ttcgtcagtc acttctgctc cagccagcac ccggtctgcg agttccatcc attgattcat 2521261 tctcataccc ccacttgatt catcagtaat gatagattga tatggtcttt taccatatgt 2521321 agaaccgttt ctttcgtcac gttggcaagc tttggcgtaa cccctaaaat cggcacaccg 2521381 cataagcgct caatcatctc aggattggtt ttttcatctt catcaggaga gtcactgatt 2521441 ccattgatga taattccggc gattggaagc cccatgcttt ctgcatattt gacagttaaa 2521501 aaggtatgat taatggttcc aaggcgagga cgcgccacaa taatcatggg aagctgcaac 2521561 gcttttatga catgactgac caaatagtcc tctcccaatg gcacagaaat accgcctgca 2521621 ccttctacga tgaagcattc atgtttttct ctaatccgcc cccaatggct taaaacctct 2521681 tccatggtga cagtctttcc ctcaagtttc cctgcaacgt atggtgcaag cggcgccttg 2521741 aaggcaaaag gcgtaatgtc ttcatgagaa agactggtct gcgacatatc tttcagcaaa 2521801 cttgtatcac tatctggatg atggcgcgat atcccgctta aaaatggttt atacaccccg 2521861 acatgtctat tattgtcttt caataaggca gcaagaccgc tggatataac cgttttccct 2521921 acttctgtat cagttcccgt cacaaaaaaa cccctcaaat gatgtgcagc tcctttccga 2521981 ttgaatgaaa tgtttgcagc aaatgatcaa tatcacccat actgtggtca gacgtgattg 2522041 taattcgaat ccggctttca cccggcgcaa cggttggcgg ccgaatggca ggagcataaa 2522101 ttcccttgcc ctgcagtttt tcagcaaata ggaccgtttt atgggcatcg ccaatgacta 2522161 caggaataat cggtgtgtga tctcctttca ccacataacc catattcttc agactggttc 2522221 tgatcatgct gatataagaa aataaaagct gtcgtttttc cctgctggct tcaatgatgt 2522281 tgaaagcctc gtgagcagcc gcacagctgg ctggcggaat agcggtttga aagataaatg 2522341 ttctggcatg gttcagcaaa aagtcgatga agaccgctga tcctgccgca aaacctcctt 2522401 ccgcgccaac agctttgctt aaggtgccga taacaatgtc gggacaaaca ccaaagtatt 2522461 cactcgttcc ttgtcccgaa tcgcccaaaa ctcctgttgc gtgggcatca tcaacgacca 2522521 cgaaggcatg atagcgtttc gcaagtgaga tgatctgatc aagaggggcg attgtgccat 2522581 ccatgctgaa tactccgtct gttacgataa aacggcgctg ataacgctgt gtttcattca 2522641 gcttgttttc aagatcattc atatcaatat gccgataaac aactgtatca gccttagaaa 2522701 gtcggcagcc gtcgatcata cttgcatgat tgagctggtc acttaaaatg acatcttcct 2522761 tttctggcaa ggatgaaagg acaccgacat tggccaagta accgctcgaa aacagcaggg 2522821 ccgcttctgt cagtttaaag ctggcaatct tcttttctag cttttcatgc cagaccgaat 2522881 tgcctgtcgt taaacgtgaa ccgctgcttc ctgtcccaaa ttgctgcaat gctgtttggg 2522941 ctgcatcgat caaacgtcta tcgcttgcga gccctaaata attgtttgag gaccagaccg 2523001 tttgattttc gccatcaata ttcctctctg gaaccggcgc tccatccatt gaccgcaggt 2523061 tacgatgtac gccggcttct ttcattctgt ctaaccgctc gtttaaccag gaatcaatct 2523121 tcaaggctcg taacctcgtg gatcgcttgt ttcataatgg caaccatttc cgagagctct 2523181 tcagctgtgc tggcaagagg aggaagaaat gcaatcacgt ccccaagcgg tcttgtcagc 2523241 attcctaact ctctcatttt taaggaaact ttgtatccaa tccgccgatc agccgggtaa 2523301 ggttctttag tttcctttga tcgtacaagc tctgcaccgc acataaagcc aagctgccga 2523361 atatccccaa catgaggaag agcgtgcaga tcttgaagaa gaaaatggag ctttttactt 2523421 ttttccgcta cttgttccac aatgttttca gattcaaata atgccagatt ttcaagcgca 2523481 accgcacagc caagctgatt gcctgtatag gaatggccat ggaaaaaggt ttttaggttt 2523541 tcataatcat catagaatgc cttatagatg tcttcagtgg caaacgtaac ggcaattggc 2523601 aaatagcctc ctgtaatgcc tttaccggca gccatcagat caggctggac attctcgtgc 2523661 tcgcacgcaa acatttttcc tgtacggcca aagcctgtag cgacttcatc aacgatcatt 2523721 aagacatcgt atgttgtaca tagctcgcgc acgcctgcca aatatccttc cggcatcacg 2523781 atcataccgg acgcgccttg taccattgat tcaatggaaa gcgcggcaat ttcctcatga 2523841 tgttcctcaa gcagctgtgc aagctctcgg aggcactgat cacggcactc atcaggatca 2523901 ccgctttcag aacgatacac ataaggaatc ggggccttgt aactctcgaa catcaacggg 2523961 ccgtatacgt ggtgaaaaag ctcaattgaa ccgacactga cggcgccaat cgtatcaccg 2524021 tgatacccgt ttttcattgc gatgaatttt tgtttctcgg gcttcccgat gttcttccaa 2524081 tactgaaacg ccatttttag ggctatttcc atcgcctctg cgccgctgtc tgaataaaag 2524141 acccgcgtga gcttttttgg gctgatgtcg attaatgttt cggcaagctg ggttgctgga 2524201 acattggtca tgcccaataa cgtggagtgc gcaatttttc cgagctgttt ttttatggcg 2524261 tcatctagtt cttttttgcg gtgtccgtgg acattaagcc aaaccgatga aaaaccgtca 2524321 tagtattcct tgccgtttat gtctttgact ttgattccag tcccgctttc gatgattaag 2524381 gggttttcat cataatcttt catttgggta aatggcagcc agaggtgctt tttacttttt 2524441 tctatcaaat catgagtcat gatcttcctc ccactctatt aaaataggct gcttctccag 2524501 gtcatgtatg tacgtgttta catcattgga tccatcaata aaaaagactc ggcagccctc 2524561 ttcagtcccg tattctttca ttgctgtaat acgctgatag cccattttct tacccgcaac 2524621 atagcctgtt atgtaatccg gatcgtccga ccagcataat tctgcaacga ctgccgggtg 2524681 ccggcttacc tttgaagcga gcgcaagggc ctcttttatt cttgaatgag ctggcacgtg 2524741 actgtgaagc gcccattttt caaaattagc gtccggccaa tccattctgg agacccgcac 2524801 ccctttttct tttgtttgat ccattcgctt gcctgtatga atatcaaaca acaccgcacc 2524861 cctgacatct gaccattcag ggatttgttc atatgctttt tcaatcacgt ctcgtgaaac 2524921 gccttctttt tccaataaca atcgggcaag cttttgtcct tcttccgggc agctcacttc 2524981 attcgtatgc acaggcaatg gctgaatggt ttttatcgat tcatgtacct cttcaaattg 2525041 aatttgcata aaatcaggtt ttcctcttga atgggataac cctttttcta ataaagcatt 2525101 gactgtatgc ttcatctcat ggaaaggaat aagccgttct ccgccggata tatgctttcc 2525161 gccgtcttca tgagatccat tcattgaagc cctcattctg acactataaa aagtttcttc 2525221 ttgcatcatt tctcgccctt tcactgataa ctgaagaacg tgtagcgctt ctcacctaaa 2525281 ttgttaacca attatattca aaggttaaca attagaatat attattctct cctgtttctg 2525341 tcaatagaag aaaggatcga tttatggcag ttggttaaaa ggaaacaaaa agaccgtttt 2525401 cacacaaaac ggtctttttc gatttctttt tacagtcaca gccacttttg caaaaaccgg 2525461 acagcttcat gccttataac tgctgtttcg aaatgtcccg aagcagaacg gaccactcgg 2525521 tagcaatcag cagctccctg tccagcatag acagctgtca attctttttc gattttgtcc 2525581 acgccctcag ccggcgttaa ccgatcgtgt acaccaacaa gactaaggtg cgggcgcggc 2525641 gcgatcaggc tttggatctc cgatgcggaa aaatgctttg caagcgatgg gacgtaataa 2525701 taaaagccgt gcctgtcaag attctgtgtt ttgatcagca cgtgatgatc cacctggctg 2525761 cacaaatcca cacacacctt aatccggtca tcgagcgccg ctgtccacca cgccatcaaa 2525821 cctcccatag acatgccgat ggttccgatc ctgtcaggct gaacatcaga gcgtgactgc 2525881 atatagtcta acgcacttaa actgtcataa atcatcatcc cccacatcac ttttccggtg 2525941 agaagcattt ctttaaatat ctcgctttcc gcttttcccc gccgatctcc aaacccccaa 2526001 tgatcaatcg caagaacgcc gtatccgagt gaagtaagct catcagaaaa agaaggcgtt 2526061 ttcaaataat ccgctccctc aatcagctca ctttttcccc tatcatactg gcctccatgc 2526121 gaatgctgaa acaatacggc tgggcacggt ccttctgttt tcttcggctt cacaaaataa 2526181 gcgggcgcct tttcatgtcc atttaaatcg agcaggagcg tttcaacgat attttcttct 2526241 ctttcttcaa tacgtaatgt ctcaacactg attggcctcc gatcaggcaa atcaccaagc 2526301 aatcgaaaca gttgctttct tctttcggct ctcatcccat cacccttcct tattcgctta 2526361 cttcacattt acgagacaga tctgggttcc cctttatttt tccaacataa atcacatcat 2526421 ttactaaata tttagtaaat attatggaat atttcgaaaa caattattgt aaccgcttac 2526481 ttttatatga taatatcaat ttatcaaaaa cagatgagtt aatattttac taaatagatg 2526541 agagggatac ccatggttcg tattaaagat atcgccttga aagctaaagt ttccagcgca 2526601 actgtgtcca gaattttaaa tgaagatgag tcgctttctg ttgcgggcga aacgagacaa 2526661 agagtcatca acatcgctga agagcttggt tatcaaaccg ttgccaaacg ccgaaaatcc 2526721 cgcgggcaaa aacagcgggc tcagccgctg atcggtgtgc tgagctgtct gtcccctgat 2526781 caggaaaggc aggaccctta tttttcttcc attcggaaag ggattgaaaa ggaatgcttt 2526841 gaacaggaaa ttttcattac aaattcgatt catctcggct cctttcagga acatatcttt 2526901 cgggaattgg atggtgtcat tgtcatcggc cgtgttcatg atgaagcggt taagcatatc 2526961 agcgggaggc tggagcatgc cgtatttatc aatcattcac cagatccgca agcatacgat 2527021 tcgattggca tcgattttga atcggcttca cgccaggcga ttgatcacct tttcgactta 2527081 ggctacaaac ggttaggcta cattggcgga caagaaaaag agcatacgct gaaggacggc 2527141 caaagcattc gcagaacgat tgaagataaa cgcctgaccg cttttttgga gtcagccgcc 2527201 ccccagcctg agcatgtgct gatcggagaa tacagcatgc gtgagggcta tcgcctgatg 2527261 aagaaagcaa tcgatcaagg ccatctgccg gaagcattct ttattgccag cgattctatg 2527321 gcgatcggcg cattaaaagc gctgcaggaa gccggactgc aagtgccgcg ggataccgca 2527381 atcgtcagct ttaacggcat tgaggaagct gaatttgcca gcacgccttt aacgacggtg 2527441 aaggtataca cagaggaaat gggccggaca ggcgtaaaac tgctgcttga ccgtctcaat 2527501 ggccgaacgc ttcctcaaca tgtcaccctg cctacaacat taatcgtaag acaaagctgc 2527561 ggatgtacag caaaggaggt gacataagca aagattcatc acgatgataa ggaggaaaag 2527621 atgaaacaca cttttgtttt atttctctct cttattctgc ttgttctgcc cgggtgttca 2527681 gcagagaaaa gctcagcaga taccgcaaaa aagacgttaa ccatttattc tacaatgtca 2527741 accgacagtg aaagagatac gttcagaaaa ctagcggcag cattcgaaaa ggaacacagt 2527801 gacattcatg tcagccttca tttcccaggc aatgactatg aaaatatgat gcgtgtcaga 2527861 atggcggcca atgatttgcc agatctattc gatacacatg gctgggggaa aatcaggtac 2527921 ggagaatata cagcggatct ccgggatatg aaatggactc aagatcttga tcccaattta 2527981 aacagcatcc tcaaaaataa aagcggaaag gtgtatgcct atccaatcaa tcaggcaaaa 2528041 gacggtctgg cgtataatcg caatatttta gaccgttacg gcattgctcc gccggaaacc 2528101 atggatgact ttatcaaagc actgagaacg attaaagaaa agagcaaggg aagcattgtt 2528161 cccttctggt ttgccggata tgacaaaagc tcattcgccc aatattacga ccaattcgct 2528221 acacctcttc tcatcacaga ccctgcccat aatgaaaaaa aacagctcat caacggcact 2528281 tttcaatgga gtaaattcac ttatttatca gaaatcctca aacaaatgca gaaagaaaaa 2528341 ttgatcaata tcgacgccgt cacggcaaaa aaatcacagc tcattgaatt aatggcccaa 2528401 aacaaaatcg cctttacaat gcaaggcggc acactcggcc aagacgttgc ccagatcaac 2528461 ccgaacgtca aggtcggcat tatcccgaca cctgccatcc atcccggtga tgacccgata 2528521 tggatcggcg gtgaacgcta cacccttgca gcatggaaag attcgcctca attaaaagag 2528581 gcaaaagatt ttatcgcatt tatggcccgc ccggccaatg ccaaacaaat ggctgaagcc 2528641 acatcgcttc cttcagggct gaccaatgtg aaagctgata ttttctacgc aaacgattat 2528701 gagtattatc aagatgtcaa agtcgagcct tacttcgacc ggttatactt gccaaacgga 2528761 atgtgggatg tcctgggcac ggttgggcag gagctcgcgg ctgacatttt ggcgcctcaa 2528821 gacatttcgc agaagctggg aagagaatat aaacgactcc gggagcaatc cgaaacacag 2528881 ggagctgaaa acaatgagtg agatcgcaag ggacgttcat gtgaaacagg ttaagccaaa 2528941 aaagcagtcc tcactttggt ggatgtacat tcctgctttg ctctccgttc tggtctttat 2529001 gatttacccg tttgtgaaag gcacattgat tacctttaca aactggaacg gattttcaca 2529061 agtctaccaa tgggttggat tcgcgcaata tgaaaggctg ttttctgatc ctgatacttg 2529121 gcatatctta aaaaacacgc tgcattacgg gcttggcagc accttttttc aaaatgtggt 2529181 cgggcttctg tacgctctcc tcttaaatca aagcattaaa acgaaagcgg taacaagaac 2529241 aattgtgtat ttgccggtga tgatcagccc gctcattatg ggctacattt ggtacttttt 2529301 cttctcctat gacggaggcg cgctcaacga tttgctcggg gtcttcggca tcagccctat 2529361 taatgcgctc gccagtccct cgctcaatcc atggatcatt gtcatgatta acacctatca 2529421 atatgtcggg atcgctatgg ttgtctactt agccggtctg caaagcattc cgaaagacta 2529481 ctatgaagcg gcgcaaatgg atggcgcgaa acaaggccag cagtttttta ccatcacgct 2529541 gccgctgtta atgccctcca ttaccattaa tatagtcatc aacattatcg gaggcttaaa 2529601 gctgtttgac gtcatcattg cactcaccgc aggcggcccc ggaaatgcgt cacaatccat 2529661 gtccacgttt atgtatgatt tgtatttcaa acggcaggat gccggctatg ccgcaacgca 2529721 aggcatattt atggcatttg tcattttgat catcagcttt tgcgcgcttg cgtactttaa 2529781 aagaaaggag acggaaatgt catgagagcc gcccgtacaa aaagcatgcg gatcattacg 2529841 cttcttgcag ccattgtggc ctgtgcgcat tttattcctt tttatatcct gctgaccact 2529901 tcattgaaag caaaaggaga ctacagttcg aaatggatat ttccagccga catctccttt 2529961 cataattttt cagaggcgtg ggagcgcgct tcgctaggaa actcttttat aaacaccatg 2530021 atcatcacag gtttttctgc cttgttatta attatattcg gctcacttgc cgcctacccg 2530081 cttgcccggc gggaaacgaa actgaataaa gccgtttttg ccttgctgat ttccattatg 2530141 atcatccctc cgttaacgtc catggttcct ttgtaccgaa tggtcgtgga cgccggaatg 2530201 gtcaatacac acgcaatcgc cattttcatc aatacagcgg cttacatgcc gttaaccgta 2530261 ttcttatatt caggctttat ccgatcgacc attccaaaag agcttgtaga agccgcaaga 2530321 attgacggtg caggcatgct gaaaatcttt tttacgattg tgtttcctct gctgaagccg 2530381 atcactgcga ccatctgtat catttcttgt gtctttattt ggaacgacta tcaatttgcc 2530441 attttctttt tacaagatca aaaggttcag acattaacag tagccatggc aggttttttc 2530501 ggagaaaacg caaacaacct tcatttagtt gccgcagcgg cacttatggc aatgctgccg 2530561 atggttgttc tgtttttggc gctgcaaaaa tactttattg ccggcctgtc ttccggagcg 2530621 gtaaagggtt aacattaaag ggggaagcaa tatgaaaaag attacattta tcggtgcagg 2530681 gagcacgatt ttcgccaaaa atgttttggg agactgcctg ttaacagagg cactgaatgg 2530741 atttgagttc gctctttacg acattgatcc caaacgcctg caggaatccc agctcatgct 2530801 cgaaaatcta agagaccgtt ataacccaag tgtggccatc aacagctatg atgacagaaa 2530861 actcgccttg caaaacgcag gctatgtcat caatgcgatt caggttggag gatacaaacc 2530921 gagcacagtc atcgatttcg agattcctaa acggtatggg ctgcgccaga cgatcgccga 2530981 tacagtaggc atcggcggga tattcagatc tctcagaaca atcccggtct tatttgatat 2531041 cgcaaaagat atggaggaaa tgtgccctga cgcatggttc ttaaactata caaatccaat 2531101 ggccactctt acaggcgcca tgctccgcta taccaatatc aaaacaatcg ggctctgcca 2531161 cagtgttcaa gtgtgcacga aggatttatt taaagctctc ggaatggagc atgacggaat 2531221 tgaggaacgc attgcgggca ttaatcatat ggcttggctt ttggaagtca aaaaagacgg 2531281 cacagattta tatccagaaa tcaaaaggag agcgaaagaa aaacaaaaaa caaagcatca 2531341 tgatatggtg cggtttgaat taatggataa gttcggctat tatgtcacgg aatcgtccga 2531401 acataacgca gagtatcacc cgtactttat taaacggaat taccctgaac tgatcagcga 2531461 gctgcaaatc ccgctcgacg aatatccgag aaggtgcgtc aagcagattg aaaattggga 2531521 gaaaatgcgg gatgatatcg tcaataataa aaaccttacg cacgaacgct caaaggaata 2531581 tggttcaaga attatagaag caatggaaac aaacgaacca ttcaccttcg gaggaaacgt 2531641 cttgaataca gggctgatca ccaaccttcc ttcaaaagcg gttgtggaag tgacatgcgt 2531701 cgccgacaga aaaaaaatta caccgtgctt cgccggagaa ctgcctgagc agcttgcagc 2531761 cttaaaccgg acgaatatta atacacagct gatgacaatc gaagcggctg tcacacgaaa 2531821 aaaagaagcg gtttaccaag ctgcaatgct tgatccgcat acaagcgcgg agctttccat 2531881 gaaggacatc atctccatgt gcgacgattt atttgcagca cacggcgatt ggcttccgga 2531941 atacaaataa aaactagggg accgctctcc cctagttttt tggttttgtt tcgccttccc 2532001 aggccatcat gccgccttca acattgactg ttttaaagcc ttgctcatcc aggtacttgc 2532061 agacgttcat gctgcgcatt cctgagcggc agataaatac gtactctttg tctttatcaa 2532121 gggtttccat tttttcagga atatccccca tgcgaatatg aacggcttgc gggatcatgc 2532181 cttccgctac ctcttcatct tctctgacat caattaaata taattcttcg tccgcctcaa 2532241 ttttttcttt caaagcggct gtgctgattt cttttatttc caaagaaaac actcctattc 2532301 acagtgatca tgttcagtat atcaaagtca gccgaacgat tgctattctg agactgatga 2532361 aaaaaaatcc ccttttggca aaggggattt tttctaggct tagtttgcca caatattgac 2532421 aagcttccca ggcaccgcga tgattttccg aatcgttttg ccttcaagct gctctttgac 2532481 cttttcatct gcttgagcaa gctgttccag ctgttctttc gttgcatcgg caggaacctg 2532541 taatttcgct tttacttttc cgttcagctg aacaacgatt tcaacttcat catccacaag 2532601 ttttgtttca tcatatacag gccaagcttc gtaggcaatt gtgccggaat ggccaagctt 2532661 ctcccatagc tcttccgcta agtgtggcgc gacaggagaa agaagcttca cgaagccttc 2532721 catatattct ttcggcagtt ctgttgcttt ataagcttca ttaataaaga ccatcagctg 2532781 ggaaataccc gtgttgaaac gaaggccttc ataatggtct gtgactttca tgaccgtttc 2532841 atgatagacg cgctccaatg tttcacccgc gccttcaacg atttttccat taagctcacc 2532901 gctgtcttca ataaataggc gccatacacg gtcaaggaaa cggcgcgcac cgtctaatcc 2532961 tgattcagac caggcgattg aagcatcaag aggtcccatg aacatttcgt acaatctcag 2533021 cgtatcagca ccgtgagagg ccacgatttc gtcaggattg acaacgttcc ctttagattt 2533081 actcattttt tcgttgtttt cgccgagaat cattccttgg ttgtacagct tttggaacgg 2533141 ttctttcgtc ggcactacgc cgatatcata aaggaactta tgccagaagc gggcatacag 2533201 aaggtgaagc acggcatgtt ctgcaccgcc gatatacata tcgaccggaa gccatttttc 2533261 caatttttct ggtgatgcca gctgatccgg attgtgcgga tcaatatagc gcaagaaata 2533321 ccagcagctt cccgcccatt gcggcattgt attcgtttct cttcttcctt ttttccctgt 2533381 ctcagggtct gtgacttcca cccactcttt aatgttcgca agcggtgatt cgcccgttcc 2533441 gctcggtttg atttcatccg tttttggcaa aatcagcggc agctcctctt ccgggacagc 2533501 tgttgacgtt ccgtcttccc aatgaatgac cggaatcggc tcgccccaat aacgctggcg 2533561 gctgaagagc cagtcacgaa gacggtacgt cactttcttc tcaccgtttt tcgtttcttc 2533621 cagccaagcg atcacttttt caatcgcttc ctgtttgtga aggccgttca ggaaatcaga 2533681 gttcacgtgc tcgccgtcgc cagtataggc tgcttcctca acgttcccgc cttttacgac 2533741 ttccttcacc ggaaggccga atgttttggc gaattcaaaa tcacgctcat cgtgtcctgg 2533801 aactgccatg acagcacctg ttccgtatga tgcaagaaca taatccgcaa tccaaatcgg 2533861 cagtttttct ccgtttacag gattgatcgc atacgctcct gtaaatacgc ctgtctttgt 2533921 tttcgcaaga tctgtgcgtt ctaggtcact ctttgattga atttctttga tataagcttc 2533981 aacagcttct ttttgctctg ccgttgtgat gttttccacc aatgcgtgtt ccggggcaag 2534041 gacagtgtat gtagcgccaa acagcgtatc tggtcttgtt gtaaacactg taaaggaatc 2534101 atcatgtcca tctatagcaa aatgaacgtg agcgccttcc gaacggccga tccagttgcg 2534161 ctgcatatct ttaatgcttt ccggccaatc aagctcttcc aagtcctcaa ggagcctgtc 2534221 cgcataagcg gtgattttca gcatccactg cttcattggg cgtctctcta ccggatggcc 2534281 gccgcgttcg ctcttgccgt caatgacttc ttcgttggca agaacagtac cgagcgcagg 2534341 gcaccagttt acaggcactt cgtcaacgta agcaaggcct ttttcgtata gctttaagaa 2534401 aatccattgc gtccatttat agtattcagg gtcagtcgta ttgatttcgc gatcccagtc 2534461 atatgagaag ccaagcgctt gaatttggcg gcggaagtta tcaatattct gcttcgtaaa 2534521 cacagcgggg tcgttccctg tgtcaagcgc gtactgttca gctggcaggc cgaatgcgtc 2534581 ccagcccatt ggatgaagga catcatagcc ctgcatgcgc ttcatgcggg acagaatatc 2534641 cgtagctgtg tatccttcag gatggccgac gtgcaaccca gctccagacg gataaggaaa 2534701 catgtccagc gcgtaaaatt tttgtttttc attattatca agagtggcaa atgttttgtt 2534761 ttcaagccaa tatgtctgcc atttcttttc tatctctttg tgctgaaaac tcaaagtaaa 2534821 aacctccttc tgattgaata cggcgtgtat ggttcaagta ttgacgggaa ggagaggatt 2534881 atattcagaa tattcccaaa ctaaaaaaaa ctccctcatc ccaaaaaggg acgagagact 2534941 ttcgttttcc cgcggtacca ccctcgttag cgcggcatac gccgcactca cttgatactt 2535001 ttaacgcagt tatgcgtcag cggcttttca ccgctgcaac tctgaggtga gttcggaaac 2535061 aaacttgatt gactttcacc agccgtcaac tctctgcaac aatatctgtt tcttactgct 2535121 cctcttcatt gttcttatcg caaccgtaat ctaactgtat tttatagaat tctgttcata 2535181 agtgcaagca ggtttgtata caatgggaat gtaccctgaa cgggcggaga ttgaggacaa 2535241 ttattcgggt ggagttttgg tttgacgttt ggactcggcc ggttcgccgc cgctgttcag 2535301 ttctctcaca aagtcaaaac ttctgagaac agcttcaccg ccgtagcctg agataatgga 2535361 taagatgaca agttgaattc ctgaatcggg gtcagcggat aatacaagta aaatggaagc 2535421 cgtcatgccg ataaaccaat cttccaaaaa tccaaggtag ataaaccgct tcgtcattct 2535481 gggcttctcc agcctgcctc tctttttcac atgaccgaga atccccatga ttcctccaat 2535541 tacacaagca atgagtacct gatgcagcat cttcatcatc accttcctaa agcccttatt 2535601 tcgtaaagcg acttcaggcc atccagcccc cttaaacgat tccgatgatt ttcgatatct 2535661 acataccggc aaatctgtaa aaagcttgtt tcttccatta tatgtgaaca catgatcggt 2535721 aagcttgatg cattggattc atttttcacc cagtgacatt gacctagtca cctatttagc 2535781 atgtagaaaa cctttccgtt catatgttca aattctgttc ttatttttag tgtatacgag 2535841 gacaagccct aatgacaaac aacaaactgc acttgcttga atcagaacat gtgttgtgct 2535901 acggttactg tagaattcat ttttaaaaag gggaatatca ggctttcgca tagcaagctg 2535961 acggcctaag ggggatttat atggctagtt ttcaatcatt tgggatacca ggacagctgg 2536021 aagtcatcaa aaaagcactt gatcacgtgc gagtcggtgt ggtaattaca gatcccgcac 2536081 ttgaagataa tcctattgtc tacgtaaatc aaggctttgt tcaaatgacc ggctacgaga 2536141 ccgaggaaat tttaggaaag aactgtcgct tcttacaggg gaaacacaca gatcctgcag 2536201 aagtggacaa catcagaacc gctttacaaa ataaagaacc ggtcaccgtt cagatccaaa 2536261 actacaaaaa agacggaacg atgttctgga atgaattaaa tattgatcca atggaaatag 2536321 aggataaaac gtattttgtc ggaattcaga atgatatcac caagcaaaaa gaatatgaaa 2536381 agcttctcga ggattccctc acggaaatta ctgcactttc aactcctatt gtcccgattc 2536441 gcaatggcat ttcggctctt ccgctagtcg gaaacctgac agaggagcga tttaattcca 2536501 tcgtttgcac attgacgaat atcttatcaa catccaaaga tgattatttg atcattgatt 2536561 tatccggatt ggcccaagtg aacgaacaaa cggccgacca aattttcaag ctgagccatt 2536621 tgctgaaatt gaccggaact gagttaatca ttactggcat taagcctgaa ttggctatga 2536681 aaatgaataa actggatgcc aatttttcgt cgctgaaaac atattcaaat gtaaaggatg 2536741 ccgttaaagt gcttccgatt atgtaaaaag atcccgctca cccagctgga tctttcagat 2536801 tgttgacaaa atcctaaaat ggttttcatt ttaggatttt gtcatctttt cagcgtgatt 2536861 gaaaaccctt gaagtctagg aaggacgagc ataggagcgg agcgaatgtt ctaattcgtg 2536921 agcaccgaag cgcaggcctg acaacgaatg cgagggtttg tcgacacgct gaaagatccc 2536981 gctcattcgg cgggatcttt tattatgaag agattgatgc ctgcttattt gtttctttag 2537041 ctgattttat ccgtttgtca tatagaagcg ttgtggcaat actgatcagc agcaatacca 2537101 acagagataa aacaagagcc ctaatgccgt aatgatcgac aagcactcct ccgaacaggg 2537161 gaccaatcat tctgccgcct gtcgccgcac tgttgacaaa gccttgataa aagccttctt 2537221 tccctttagg ggcaagctga ttggcaatag tcggcacagc aggccaaaca agcatttctc 2537281 cgatagtcag gatcaccatc gcagcgagaa acatcggaaa ttgctttgca gtcagcagca 2537341 tgctgaaaga cacaataaaa atgataaagc cgatgaccat ttgcgctttt agcgactcgg 2537401 cccatttttt caccacaaaa ctgacgagcg gctggccgag cacaatgaga attccgttaa 2537461 ccgtccacag cacgctgtat aaggaaagag atattccaat gctttgtgtg tacgaagcaa 2537521 ttgtggttga ccactgagaa taagccagcc atccgagtac atagcctccg cttaaaatga 2537581 tcagtgcggc aaattttgct ttgctgttca cagcatcata atcaagcacg gatgtttggg 2537641 atgcatcgcc cgtttgaata tttcgaaatc cgaaatatac aataaagaaa aagatcagat 2537701 acaatacggc atttgccaaa aatacatatg aaaacgagaa agatgccacg acaccgccaa 2537761 gcgctgaacc aacggccacg cccgcgtttt gcgcgacata tatcgcatta aatgccttcc 2537821 ttcccccttc aggccatacc gatcccgcca ttgcgtagct tgccggaaaa acaacaccgg 2537881 agccaaagcc cacaatcgtc agcagcacaa tataggctgg ccaatcatga aaaaagacaa 2537941 gacccatcag gcttgctaac gtaatggcta tcccaagcat aatcgattta aaaccgccga 2538001 ttttatcaaa caaaaaacct ccgcataaat tgccagccac actggcgccg gaattcagca 2538061 tcaggacaag tccggctact gttaacgact ttcctaaatg attatggata taaatcgtat 2538121 tcagcggcca taaaaaagaa gcacccgtca cattgataaa cattccaatg actaaaattt 2538181 taagagcacg cggcatactc atcccccttt cttacctaaa aaagctcatg aaaaaaacga 2538241 aacctaaaac ggctccgtac gaatccagtt atcatagcac attcattcta tctgtctctc 2538301 tcacattttt caactgatga gcgtgaaaaa atctaacaaa tattgtttga aaaatgtaaa 2538361 ataaatagaa aaaggggtca tattatggaa atggtattag cattcttagg ttttctggca 2538421 tgtctcattg cactgggcta tggattatat caccttgtca gatatgtact gaaaaaggaa 2538481 aaacgtttct caaagagact tttttggccg cttttcattg gaggccttgt gctgctcttt 2538541 accggggcag cattggcaga acctgacact gccgcagcaa atgccgagaa aaaatattca 2538601 gcgctaaacg ccgaatataa aaacctcaca aaagagcacg aagaacttga gaaagaatat 2538661 aaatctgtca gctctgaagc aaagaaatta aaagacaaca aagaagatca agacaagctt 2538721 gagaagctta aaaacgaaaa tagcgatcta aaaaagactc agaaatcatt aaaagctgag 2538781 attaaagagc ttcaagaaaa tcaaaagcag ctcaaagaag atgcaaaaac ggcaaaggct 2538841 gaaaatgaaa cacttcgaca agataaaaca aagcttgaaa atcaattaaa agagacggaa 2538901 agccaaaccg ccagctctca tgaagacact ggaagttctt caaacaatac gagtaaaagt 2538961 gatgaaacca aaacagctga caaagcagaa ggctgtaata tcaaaggaag cagaaacggc 2539021 atctaccaca cgccaggcag tacatactac gaccggacaa ccgatccggc tgaaatgttt 2539081 tgctcagttg aagaagctga agccgccggt tatcgggcgc caaaacgata aacaaaaagc 2539141 tccagaatgt ctggagcttt ttctgtttca caacgacgat ttaatgacct tcttataata 2539201 aagaactgac agaaaaccaa aaatggagta gagcgcagta tataacacca tcaccataat 2539261 cataggcgcc catacctctg atccgaataa gaaccagccg gattggacgg caaagtaact 2539321 gtggaagagg ccgacaacga gcggaatgcc gaagttgtac atttgtttga tgcgtatccc 2539381 ctttatcagg tcgccctgcg taaagccgag ttttcttaaa attgtatagc tcggtttttc 2539441 atcttcactt tcacccattt gtttaaaata aaggatacaa cctgatgtaa tcaggaacgt 2539501 taaccctaag aagccgacga tgaacatcac cataccaaac agtgattttt gcgcagcgct 2539561 tgtatctagt cttgataaat gctcgttttt cttgttcacc tgttgaaaaa gctcatttgc 2539621 tttttccatt tgatcgtcat gtttcacatt gacgccgata aatgtagatt gcgccagctg 2539681 aatgcggggg tctttatcct tgtccagctg tttaaacagg ctgtcatcca caatgacagc 2539741 gggcatgccc ccgcttgtaa acgtgtagga cacaagaaac tcttctctta atcctttata 2539801 ttttaatggc tgcgtctcgt gcttgctttt tactttaata acaccagagt ccttgaaaac 2539861 cattattttt tgcagcaagt cggtgtatcc tgagaaaacg gcttctccag ccgccacatc 2539921 gactcctttt acatctttgt cgctaacaac agcaagctgc atattgccgg gatcgccctg 2539981 catctctttc ggagttccat ccataatatt tgcaatgtca acatttgctt gcaggacagg 2540041 tgttgccttt tttacaaacg agatgttgct ttccctcaat ttgttttcaa ataacttggc 2540101 atctttctca ttcatgaatg aaaaatcagc cgctacattt tgttcagcgg tcttttccga 2540161 cgagtaatac gagatgtaag caagagataa cagcccgatg gcgagcgctg aaacggttgt 2540221 aataatcgtc agcagcagcg cattcgattt cattctgaac atgatcgaag acagtgacag 2540281 aacctcagaa atatttaagt agccgccctt gctttttcga atgatattcg agataaacgt 2540341 aactgatcct ttataaaaca aaaacgtccc gataatgacg ctccccagaa tgaagctcat 2540401 cgcaacaaac agttcattaa tggtcttaaa ttttccgcca aacagctcag aagacacata 2540461 gtatcctgtc aaaatcaaca cgatgcctaa agcgccgatc agcatttgga aaaatgatat 2540521 tttcttcact ttgtcttcag tggaggacgt tactttaaac aaagataaaa tactctgttt 2540581 tttgataaac gtataattca tgatcatgat caaaaggtaa atgccgcaga acacaatgac 2540641 cgtttggacc aaggcctgct cagaaaaatg cagtttcgca tccgctttga catcgacaat 2540701 tttgaacaga atcatcaaga caagcttcga tatcgaaaac ccggccgcta ccccgatcgc 2540761 taatgaaccg aaatacagca tgacattttc tgcacttaag atgcgaaaaa ttttatgctt 2540821 cgtcattcca attaattgaa acagcccgat ttctttactc cgtctcttaa taaaaatcgt 2540881 attggcatat aaaatgaaga tcgccactac agccacaagc aaaatcgaag cggttttaat 2540941 agccgcggct cccttgattg aagccttcac ttcgttaatt gctggatcat actgcagcgt 2541001 gacaaaggcg aaataaagcg ccacgctaaa gatgagcgca aacacataca aatagtaatt 2541061 ccggagattc tttttcaaat ttcgcaggat gagctgatta atgttcatgc tgcaccccgc 2541121 ctaacacgcc ttgcgttttc ataatatcct ggaaaaacgt ttgcctgtcc tggccccctt 2541181 tattcagctg tgtatacatt tgcccgtcct taataaaaat gactctgccg cagtagctgg 2541241 cagcgacggg atcatgggta accataataa tcgtcgcgtt gcgtttttga ttgagctggc 2541301 tcagcttatt taatagatcg gaggccgatt tcgaatcgag cgcgccggtc ggttcatcag 2541361 cgaaaataat gctcgggtca tgaataaacg ctcttccagc ggatgttctc tgcttctggc 2541421 cgccggaaat ttcattcggg tatttatccc gcaattcata tattcccagt tccttggcaa 2541481 cttcctcaaa cttgcgattg gcttcctttt ttgatagttt cgtgatcgat aaaggcagaa 2541541 ggatattctc tttcactgtc aatgtgtcta acaaattgta atcctgaaag ataaagccta 2541601 aatgctgttt tctaaattca gccagctgct tttccttcat agccgtcatg tcatttccat 2541661 taatatgaat ggttccgtga ctgacctgat cgattgagga cagaacgttg agcaaagtgg 2541721 tttttcccga cccggaagca cccataatac tgacgaattc gcccttttca atgtgaatat 2541781 cgatgccctt cagcacttcc tgtttattca gcttgtttcc ataacttttt cgaattttat 2541841 tcgcttctaa aatcaccatt tacgcagtct cctttatatt ggataatctc attataaaaa 2541901 ggaatgccgg gcttttcctt cgatacggcg aacaaaaaag aaaagcatgt gacattttcg 2541961 tcacacgctt atgacatgtt caaattgatt ccgtattgga aaggttaatg taaaaactgt 2542021 tcccgcacca aactccgact caacatcaat atggatcaat aacggcgccg ctgctttttt 2542081 tgccaagtac agccccatgc cagttgacgc ttgatcatgg tgatccgttg tggatgtaaa 2542141 ccctttatca aaaatacgcg gtacatcttt tggatcaatg cccctgccac aatctttcac 2542201 ttggagctgc gtctgttccc ctttttgaaa gcttttgatc tcgatttcag aggcttcgct 2542261 gtatttcacc gcgtttgtca gcagctgcct gatgataaac gccagccatt ttgcatcgct 2542321 cagcacttct ttggcctcga gctgtatgtc aaaaccgatc cctttttgga tacaccacga 2542381 ttgtaaatct ttgatttctt taaagatcaa aggctgaagc tgaatgaatt ctactgacag 2542441 gtcgttttca ataaatgaaa tgcgtttttg atgaagctgc tgatcaagaa gcaggtgaat 2542501 acgcagccat tcatatgaca gctgggattt cagtgctttt tcttccattc tatcaatgat 2542561 taaatgcatc gctgttaatg gagttttgac ctcatggatc catgccatca gctcatcttt 2542621 ttcattttcc aatgctaagc gatgccgtgc tgcggtctgc ttcaagtgtt ctgtttgccc 2542681 ggcaatgctt ctttcaacca ttgcttcaaa cggcgtttcc ggttcattta tggctgtcac 2542741 atcgagattg ttctcccatg ttttcaagct tttataaaac gctgtttctt tccgatagcg 2542801 gaaccaaagg aatatgataa aaaacaagat gcacaaatac accatataaa gtacattccc 2542861 aaatgatatg gaaggatcga caaaagcaat gaacagcatc aaagcctgct gaaacaaaaa 2542921 cgcggcaatc cagctccgcc tttcgataag gaatgcttta atcatagaac ttgtcctctt 2542981 ccttcgcgat gtagccctgg cccacctttg tctcgatata tgcaccaagc tgcagggcgt 2543041 ccagtttttt tcgcaggcga ttgacattga cggtcagcgt attatcacta acaaaacgct 2543101 catcgttcca caagcttctg atcagctctt cccggctgac gatcttgttt ttttgctcta 2543161 ttaattgttt tagaatgaac atttcatttt tggtcagttc aacagatcct ttgtcattgc 2543221 tgacgaggtt ctgctccgcg tctacagcag cgccgcacca cgttttaatc gtactcggct 2543281 ccgtattata atggtgcaca cgccggaaca tcgcttggat tttcgcgatc agcacatcaa 2543341 aatgaaatgg cttttgaata aagtcatctg ccccgagctg catggacatc accatatcag 2543401 caggatgatc ccgggaggat aaaaagagaa tcggaacatt tgaccgggag cggatcagac 2543461 ggcaccaatg aaagccgtca aatttaggca gctgcacatc aataatgaca caatcaggat 2543521 taaccgccgc aaattcctgc agcacctgac tgaaatcctg aatgccgtat acatcatagg 2543581 accatcccgt taaacgatcc ttgatttcat gaaacagcga ttcatcatct tcaatcagca 2543641 aaagtttaaa caatcgactc accgcacttt ttcctttttt atcaagtgta tagcaaaacg 2543701 ccagcatgcg ctatagaaaa agccggctgt ctcagccggc tcgttcgcat tataattctc 2543761 ttctcaacgc tgtcagcacg ttggttttgg tagcttttct cgccgggttc attccggaaa 2543821 tgactgcgac ccctccgcaa atcacaacgg caatgatcac aaggctcgcc gggatgtagg 2543881 agaatgtgta attcaaatcg cccgcatcgc caccgcttgt ggccgcaaga atcatcggaa 2543941 cggccaggtt gacaaggtag ctcacgccgt aagaaatgat aatcccaatc acacagccta 2544001 aaattccgat atacgcgctt tccatcaaga acattcggcg aatgattgac gggctcgccc 2544061 caatcgcttt cataatgccg atctcttgcg ttctctctgt caccgccatc gtcatcgtgt 2544121 taaaaatgcc gatcgctgaa atgataactg cgatacatcc gacaaagatc agtccgattt 2544181 tgaagaccat gaagaaggta ttggctccct caagttcagt agtcactgat gtgacatagt 2544241 acccgtcatc tgttagatca tttgtcagct gttccacatt ctcaaactta tcagcaaaaa 2544301 caccaatgtt cgtttcaaca tttccgcctt tgaaatctaa gaattccgaa aaatcttttt 2544361 tgaattgatc actgataaaa atatttgagt cctccatcca gtcttgagat ggtttttttg 2544421 taataccgac aattttaaag tcatatgttt ttgtttttgt aacatcccct gttttagaat 2544481 ctgtcttcga tacacttagt tcaattgttt tatttagaat atctttcgta tagccctttg 2544541 gttcttttat atcttctgga tttccttttg cttcctcgat ttttttgtta tattcttccg 2544601 attctttttt cgttaataat ctctttgcga agtcgtatcc tactacgatt tcattttccg 2544661 actttgcgac tcttcccttt tccaattcca tattggcctt taattcatca ttcatattag 2544721 taaaaatgag atttgagctt tcatttgtac gattgcctaa agtagctttg tttggttcat 2544781 acacttgcgt tctttctaca actgacctta cgtgatcata cttctctaaa tcagcttttt 2544841 taatcggctt gtctccttcc ttgcccatta cgctgacttt cgttacaatc tgctggctca 2544901 ttgtcatatc tgtaatcgtc ttttgaatcc caaatccaac ggacgacaac acaaccaaaa 2544961 acgcacacgc cattgttgtc gccagaatcg tcataaagac gcgaagcctg tttttcttca 2545021 tatttcttct gataaaatga acctgatcct taaacctcaa cggtaattcc tccttttagc 2545081 acaccatcat gaagctgaaa ttttgaatgt ccgatagaag cgacttcatc atcgtgagta 2545141 atgatcacaa atgtaatgcc acgctcacga ttcagctgct ggatcaattc cagcacttca 2545201 tgttccgttt ctgaatcaag gcttcccgtc ggctcatccg ctaagataat cgaaggattt 2545261 aaaatcaatg ctcgagcaat actgacacgc tgctgctggc cgcctgacag ttcattcgga 2545321 taatgagcgg cgtggttttc cagaccgacg cgtttcagca tgtcctgcac cttttgcttc 2545381 cgctcagatg gcttgattcc ttttaacgcc agcggcattt ccacattctc atacgtcgtt 2545441 aaacccggga tgagctgaaa gctctgaaaa ataaacccga aatggtcaag ccgaaattgc 2545501 gcccattcct tttcattaaa ccccgtaaca tcagtgccat taatgacaat ccgccctttt 2545561 gtcggcgata tgtagccgga aattaaattc aaaagcgttg atttccctga gccgcttcgt 2545621 ccgacaatgc aggcgatttc ccctttcgcc acgctcaatg aaacatcctt caatactgga 2545681 acttcattct cacggccctt ttttccgatc gtgaaagaat ggtcgatatg ctgaacatca 2545741 atcatatgtt ctctctccct tacaaaagtt tcattttttt ataaatcgca aaataactaa 2545801 tcaagaaacc gattaccgca cctgtaccca tgccaatgag ataaccggca aagctctcgc 2545861 ttgcagtaaa tccaaaatag ccgaagccca tgattcctat gataataacg atgatctgca 2545921 ccgggcggtt aagcggcttc cataagaaga aatatccgtt tctttcatta gacattttaa 2545981 caaagctaat atagccgatg atgtaaaaaa tgatagtcat gatagccgga atgactaaat 2546041 aatatggtga attctcagcc catttcgagt ctacataaat tatcggaatg aaatactgca 2546101 cccatttagg tactggacca tggataaaat ctattgatcc gccaaaaagg atctcgaggt 2546161 tgatcacagg caggctgatg agtaaaaacg gcgaaatggc cacggtaaat gagactagaa 2546221 gctgtgcgaa actattgcct gtcaaagctc ctccggccat aaccaaagaa taagccagca 2546281 tgctaacaat aatcattccc aagctgtaat tgtgaaaata aacggcctga tctggcttca 2546341 aaagcatgat cagcaaaaca gacaaaacat aacctatgag ctgcggcacc acaatcacca 2546401 ttccgccggt aaggaacttc gcatgaaata tctgccctcg tgtatatgga aggcttaatg 2546461 taaaatcaaa gaagctcttg ctacgttcaa tcccaagctg gctgaccgcc aaaacgactc 2546521 cccaaatcca aaacaatgag ataaatgagc tatttaaata atcaacgctg aatacgcagg 2546581 ggccgaccca attttctttt ccagtgacac agccttgata gatgagatac atatttaaaa 2546641 ttgataatgg attacctaat ataaaaacca aaatggtgat aactaaggcg actttattct 2546701 gccgccactc tttgtaaagc agtccggaat ccggcaactc acttccctcc aaacctaagg 2546761 catttcttac acttttgttt tcttataaat agagaagtag ctcacaaaga atccagccac 2546821 tgctccaatg atcataccca aaatataacc aataatggaa tgtccggtat agtatccaaa 2546881 taaaccaaat ccaaggatgc cgaaagccat aaccagaatt tgcaccgggc gatctaatct 2546941 gttccataag aaaaagtgtc cgttccgttc acttggaagc ttcttgaagc ttataaagcc 2547001 aatcaagtaa aatagcatgc tcattacggc tggaatcaat aaaagatatt tactgttaat 2547061 cagccattca tttacaacgt aactaatcgg tactaggttc gataaattgc ttgccagaga 2547121 gaaataactc tcaggggaag ggaatatttc ccatatattc gcaccaaaaa caacttctag 2547181 gtttccaacc ggcaatgcaa taattaaata cggcaatata gctgctgaaa acgccgttaa 2547241 cagttgggca aaagcatttc cagttaacgc tccggcggcc atcaccagtg aaaaagccat 2547301 aaaacttatc acgattactc caatgctgct gtgctcaaaa aagtagacgt gttcagggtt 2547361 atagacaaga atcagcagcc atgcaagtaa aaagccaatc aattgtgaca gcacaatcac 2547421 aaaaccgcct aaccaaaatt ttgtctgaaa aatttggctt ctgttatacg ggaggcttaa 2547481 tataaaatcc atcgtgcctt tcgaacgctc cattccgagg aagcagaccg ccaaaatgac 2547541 acccggcacc cagttgatat ctatcagatt gcttatggaa taattcacaa taaaatcaca 2547601 atattgcggg tcttggcgat caagacaccc ttgataagac aaatacgtat taacgataga 2547661 aagcggattt gccaatacta aaaacgcgat acttaacaaa atcaccactt gattctgctt 2547721 ccactctcga tagaggagac ctcggtctac catctccgct tccctccaaa cttcgcaatg 2547781 aacacttctt ccaggttgac aggaagctca ttccacactt ttggcttcag ctctctcaaa 2547841 aagctctttt tctcctcatc gcttttcgga atcagcactg tgtaaaacac gccggcctga 2547901 tcgagcatcg gaatgttttg ctctctgatg gccaaattga catctgtatc gaaggccatt 2547961 tgaattttaa tgtattcttc ttttaactca tcaagatcca tgacgttggt caggctgtta 2548021 tcttcaagaa aaccaattcg gttgcacatc cgctctatgt cttcaagccg gtgggacgta 2548081 atcaggatgc tcgtatcacg ctctgccact tcatcgacca tcagctgcag cacatcatgc 2548141 cttgtcaccg catcaatacc atccgtcggc tcatcaagga ggatcagcgc cggtctcgcc 2548201 gcaaacgaca gaacgagcga tagctgcttt tttaagcctg tcgacagctc acggtatttt 2548261 ttcgtttccg gaatttcgta tctgttcatc agctcattcg cgtacgtgac atcaaatttc 2548321 ggatatattc ttctcaaaat atcgactaac tgcttgtatg tatacttatc gtaaaacgga 2548381 ttttgaacag gcatgtagat gatattttgt ttgactttcg ggtgcttttt gatttctacg 2548441 ccgtcaaata aaatcgttcc gctgtcagcg aaaatgattt gctggattaa gcgaagcatc 2548501 gtcgttttgc ccgatccatt gcgtccaagc aatccaaaga tttctccttt ttcgattgtt 2548561 aatgaaacat cttttaatac ttgattgccg tcaatcgctt ttgacagctg ccgcagttca 2548621 atcatttttt ttgcctccct tcacatcagc gctgatttcc tttatccatt cgtgcagttt 2548681 ttccagctca acccctgcat agtgtgcatc gatgatgagc tgtttgagtt gctctttaat 2548741 catcgtcatc ttcccttcaa ccagtgtcgt ttttgcattc tccgatatat aggtccctct 2548801 gccccgcagc gtttcaataa tcccctctcg ctcaagttct ttatacgctt tgctgacagt 2548861 gttcggattc gcaataatga tcgttgccaa ttctctgaca gaaggaagct tatcaccagg 2548921 cttcatgatc cctttcaaac aaagctcttt catttgctga ataatttgtt cgtaaatggg 2548981 tgttgagctt cttggatcga tttgaatcat ttacttccct actttctata cgatctgaac 2549041 cttttataga taaaaatgat caattatact tttttgccat tcaaaaccga tcatcacaag 2549101 aacaagaaaa aaagaacaag cgatcacaga tgccgcaatc agcattggca cgttacgttt 2549161 gtttcgtttt ttatgtttca taactgcctc ccttaatgtc aatatataaa tgattttata 2549221 ttagtgtcta tagtgtatta cttcaattag tacacttaat acaataaata ctttgactca 2549281 caaagtcaat ccttttttta caaaaaaacg gaccctttta aaagggtccg ttttcctaca 2549341 catcaagagg gtgctgcagg atcatattat tttgcaaaga ttgaagctga agtctcattc 2549401 tgtacagctg ttctctctgc tgatcatttg acgacagcca tagtttattc aaggcattta 2549461 ccgcatcttc tagctgcatt tgtgcatcac tatattcttg atcgttataa tgctcttgtt 2549521 tagaagcgat tttcagctgt tcttcagcat aatcataggc ctgcatacat tgctggagat 2549581 gttcatctac tgattgtctt gttgccacag taacccctcc tcttggtaat ggaaatcatc 2549641 catcattcat attgtagcct catctgactt tattcaataa agtaatttat ggtcgatatt 2549701 catttgttct cttgtgaaat gcgtgctaca attttaggat gcaatcgtac gcaaggaggc 2549761 acatgaattg tgatgcagaa caatcctttt ccttattcaa atacggaaaa acgctatcat 2549821 acattgaatt atcatctcag agaacatttc ggccataagg tgtttaaagt agcgcttgac 2549881 ggcggttttg actgtccaaa tcgggatggc accgtagccc acggaggctg tacgttttgc 2549941 agcgcagcag gctccggaga ttttgctgga aaccggaccg atgatttaat tacgcaattc 2550001 catgacatca aaaaccgcat gcacgaaaaa tggaaggacg gcaagtacat cgcttatttt 2550061 caggctttca caaacactca cgccccggtt gaggtgcttc gtgagaaatt cgaatccgtc 2550121 ctcgccttag atgatgtggt cggcatttcg atcgccacac gcccggactg tctgcctgat 2550181 gatgtcgttg attacttggc agagctgaat gaacgtacgt atttgtgggt ggagcttggg 2550241 cttcaaacag ttcatgaacg gactgcactt ttgatcaacc gcgcacatga ttttaactgc 2550301 tatgtggaag gcgtcaataa attaagaaaa cacggcatac gtgtctgctc gcatattatc 2550361 aacgggctgc ctttggaaga ccgggacatg atgatggaaa cggcaaaggc cgtcgcagat 2550421 ttggatgtcc agggcattaa aatccatctg cttcacctac tgaaaggcac gccgatggtc 2550481 aaacaatatg aaaagggcaa gctggaattt ctttctcaag atgattatgt gcagctcgtc 2550541 tgcgatcagc ttgagatcat tccgcctgaa atgatcgtcc accgcattac aggtgacgga 2550601 ccgattgagt tgatgatcgg gccaatgtgg agcgtcaaca aatgggaagt gcttggcgcc 2550661 attaataaag agctagaaaa tcgaggcagc tatcaaggaa agttctttca acggcttgag 2550721 gaggaatcag cgctatgatt ttgaagaaaa ttcttcctta cagcaaagaa ctgctgaaaa 2550781 tggccgcggg agagggagat attgtcgtag atgcgacaat gggcaacgga catgatacac 2550841 agtttttagc ggagcttgtc ggtgaaaacg gccatgtata cgcattcgac atccaagaat 2550901 cagccgtggc caatacaaag gaacggctcg gtgacatgta tcaagcgcga acaacgttat 2550961 ttcacaaaag ccatgataaa atcgctgaat ccctcccgcc tgaaacacat ggcaaagtgg 2551021 cggccgcggt atttaacctc ggctatttgc cgggcgggga caaatcaatt acgacaaacg 2551081 gcagttctac gatcaaagcc attgaacagc ttctcagcat catgaaagac gaaggtctga 2551141 ttgttctcgt cgtctatcat ggccacccgg aaggcaaagc tgaaaaaaac gacgtgctcg 2551201 agttttgccg ggacttggac cagcaaacag cccgtgtatt aacatacggg tttatcaatc 2551261 agcaaaatga cccgccattt attgtcgcca tcgaaaaaaa agctcagatc agcaaatgat 2551321 ttgagctttt ttctttgaat ttttcatcca ggacattttt tgaaatttcc ggtaggctct 2551381 gccgttgata taaaagaaaa gggaggtttt tccgctggct ttgatcagct tctttgcgag 2551441 ccggacctgc ttcgtcttac tttaccattt ttcaaattat atttgaaagc aataaccatc 2551501 gttaacccgg acgtcataca gttcgggttt cgatttttcc ataaaacgtt cacatatagc 2551561 atgaaacgta tgacttttat cttatcacaa aactataaac agcctctgca aaaacacata 2551621 cctattcttt cctgttctct attttctatg agcacacaca aaaagagccc actgggagct 2551681 ctttttgtca gctgatattt cgttcgctgg cagcagccgc atttttttta tgaaaccctt 2551741 ttccatagta cacagccagc aagatgagaa accatatcgg cccgataatc acggctactc 2551801 ttgtatcagg gctgtaagcc ataagaatga cgacgaatgc tagaaatgcc aatgacacat 2551861 aagacgtaaa cggaaataaa ggcattttgt actttaattg tttcttttct tccggcttca 2551921 aacttttcct gtattttatt tgagaaagca aaatgattgc ccacgtccaa atcgctccga 2551981 acgtcgcaat acttgtaacc caagtaaata ccttcgcagg gacaacatag tttaacagca 2552041 ctccgactaa taaagcgccc gctgaagcca gaacagcttt acccgggatg ccgcctttcg 2552101 tcagctgacc atatgcttgt ggcgcctctt tctgttccgc caagttaaac agcatccgcc 2552161 ctgtgctgaa aataccactg ttgcatgaag acagcgcggc tgtcaacacg acaaagttaa 2552221 tgatacctgc ggccgatgga atgcccactt tttgaaatgt gagaacaaat ggacttcctt 2552281 gagagccaat ttcctgccac ggataaatag acataatgac aaataaagcg cctacataaa 2552341 aaatcaaaat ccgccaaaat actgtatcga ttgctttggc taacgatttt tgcgggtttt 2552401 ttacttcgcc agccgtcacc ccgatcattt caatccctaa ataggcgaac atgaccattt 2552461 gaagagacaa taaaacccct tttaatccat gagggaaaaa tcctccgttg ttccacaaat 2552521 tgctgattcc ggttgcaatg cccccattgc cgactcctgc aataatcatc aataaaccga 2552581 cagcaatcat ggataagatt gcaacaattt taatcaatgc gaaccaaaat tccagctcgc 2552641 cgtaagcttt gacagccagg aaattaacac ccgtcataat gaccagtgcc gataacgccc 2552701 aaatccagtt tggcacgtcc ggaaaccaga accccatata gatgccgaca gcagtgattt 2552761 cggccataca ggtgacaacc cataaaaacc agtagttcca acctgttaaa tagcctgcaa 2552821 gcggtcccaa ataatcacgc gcatacctgc tgaaggagcc tgcgaccggt ttttgaatgg 2552881 ccatttcccc aagcgctctc ataataaaaa acatgaccag gccgcttgcg gcatacgcta 2552941 ccaaaatacc aggccctgct aattgaatag ctgatgcgga gccgaggaac aaccctactc 2553001 ctatagcagc tcctaaagac attaaagaaa tatgcctttc ttcgagtccg cggtgcagct 2553061 cttgtttttg tttttgcatg cttcttctcc cctagaaaaa aatatcatta tatcattttt 2553121 ctgaatattc cgtacggatt gggtaaatca atgatgatgg agaaataaaa ggataacaac 2553181 aaggctttcg actactcgaa agccttgttg tctgttacac aaagatgact tctttaggct 2553241 gatggctcag ctcttcaggc atataccgtt tttcaatatt gatgctgtgc cagatcataa 2553301 agattagcac agtccaaatt ttacggctgt tatcagcctt gtccgcacaa tggtcttcaa 2553361 gaagctgaag gacataatcc ttatggatat aagcatccgt ttggctttct tgaataatat 2553421 tccgcaccca ttcgttcatt tcgtttttca gccaatgacg gatcggtaca gggaaaccaa 2553481 gctttttgcg gtttaatacg tgctcaggca caattccttc agcggctttg cgaagaagat 2553541 acttcgtcgt gccgttcttc gttttcagct catcaggaat ttttgaagcg acgtcgaata 2553601 cgactttatc caagaacggc acacgcagtt ccaaagaatt cgccatcgtc attttatccg 2553661 cctttaacaa aatgtcgccg cgcatccaag tgtggatatc gacatactgc attttgttga 2553721 tatcgctgta cgagctgctt tctgtaaagt aagtcttcgt cacatcgcga tatgaaaggt 2553781 tcggattata atgcttcaac agctgctttt tgacagactc ttcaaagatt ttcgcgttac 2553841 cgatataacg atcctgaagc ggagtgcagc cgcgctcaag caggctcttc cctctcatac 2553901 cttcaggcat aacggcagca acgtgcagaa gcatcttttt caagccggac ggaatccgtt 2553961 caaacggttt aagcgaaagc ggttcacggt aaatgttata tccgccgaag agctcatccg 2554021 ctccttcacc tgataaagca accgtaacat gtttttttgc ttcttttgca acaaagtaca 2554081 acggaatcgc tgccggatca gcaagcgggt catcaaaatg ccatacgatc ttcggaagct 2554141 cattcatgta ttcctcaggc gaaatgactt tgctgatatt ttcaatgccc agcgccgctg 2554201 ccgtttcttt cgctacatca acctcactga agccctgctg ttcaaagccg acagagaatg 2554261 tttttaagct tggatgaaat tccttcgcaa cagacacaat aaaggaagaa tcaatcccgc 2554321 cagacaggaa cgaaccgaca ggaacgtcac ttctcatatg aacgtttaca gagtcataga 2554381 tcgcgtctcg gacttctttc acaagcttgt cttcttcagt ctgaaccggc ttgaagttcg 2554441 ctttgaaata cgttttgaat gtgatatcgc cgtccgggcg gattgtgaat tgtgaacccg 2554501 gctctacttt tttcacatgg gcatcaagcg tgcttggttc aggaacaaat tggaaagaca 2554561 tgtactgctg caatgcctct ttatctattt caatatcatt ctgagcaacc attaaacttt 2554621 ttctctctga ggcaaaataa acctgatcat tgatcgttgt gtagtacaac ggtttaatgc 2554681 cgaatggatc tcttgcccca taaagcacat gatcgttttt attccaaatc agaaaggcaa 2554741 acataccgcg cagtttggac gccgcttctt ctttatagtg acggtaagtc gcaagaagaa 2554801 cctctgtgtc cgaatccgtg ttgaatgtgt acccctttgc ttcaagttct tctctcagtt 2554861 cgatatagtt atagatttct ccgttaaaga taatccaata tgtttcatct tcatatgata 2554921 aaggctgtcc accattttct acatcaataa tgctgagccg tctgaatccg aagccgacgt 2554981 gctcatcatg gaaatatcca tcactgtcag gaccgcggtg aacgatcatt tggttcattt 2555041 gtttgattag ttcttcttga tcagcggttt gagctaacgg atgcttgtta aaaaccccga 2555101 caaatccaca catagtattg cctccataat taaaattgtc atcattgaac ccctatttat 2555161 agacgctgtg aatagtattt ggtttcacag ttatgtaaaa aaataaacat gaatacaacg 2555221 ataaaaaagg gaaagccgct taaccagtaa gcggctataa aattattctc ctaacgcttc 2555281 tttacgcagc tgctccgctt tgtctgtgcg ctcccatgga aggtcaacat cgtgacgtcc 2555341 aaagtggccg tacgcagcag tttgtttata gatcggacgg cgcaaatcaa gcattttgat 2555401 aatgccggca ggtcgtaaat caaagttatt gcgaacaact tcaatcagtt tttcctcaga 2555461 agcttttcct gaaccgaatg tgttgattga gattgacaca ggctgtgcaa caccgatcgc 2555521 gtaagcaagc tgtacttcgc aagaatcagc aagctcagcc gcaacgatgt ttttcgcaac 2555581 gtatcttgcc gcataagctg cagaacggtc taccttcgtc gcgtccttac ctgagaacgc 2555641 gcctccgccg tggcgtgcat agccgccgta cgtatcaacg atgattttgc gtcctgtaag 2555701 tcccgcatcc ccttgagggc ctccgattac gaaacgtcct gtagggttga tgaaatattt 2555761 tgtttcttca tcaatcagct cttcaggaac aaccggattg attacatgtt ctttaatgtt 2555821 gcgctgaatt tgctcaagtg taatttcagg gtgatgctga gttgaaataa caatcgcgtc 2555881 aatgcggact ggtttgttat tttcatcgta ctcaaccgtt acctgtgttt tgccgtcagg 2555941 gcgaaggtac ggaagaatat cttctttacg gacttcactt aggcggcggg ctaatttatg 2556001 ggcaagtgaa attggaagag gcataagctc tttcgtttcg ttgcacgcat aaccgaacat 2556061 taatccttgg tcacccgcac caatcgcttc aatttcttcg tcgctcattg tgccttcacg 2556121 ggcttcaagc gcttggtcta cgcccatcgc gatatcagca gactgctcat caattgatgt 2556181 taaaaccgca caagtttccg catcaaatcc gtattttgca cgtgtgtatc cgatttcttt 2556241 aatggtttgg cgaaccgttt tcggaatgtc aacatacgta gaagttgtga tctctccgct 2556301 tacaagaacc aaacctgttg tcacagatgt ttcacaagca acacgcgcgt tagggtcttt 2556361 ctttaaaatt tcatctaaaa tgctgtcaga aatctggtca cagattttat ccggatgccc 2556421 ctccgtaaca gattctgatg taaataaacg acgattttta ctcatgattt gcttcctcct 2556481 gcacaaggcc tcccgaaaga ccttgtatat atgatacgga actcgctccc tcttatacaa 2556541 tgtacagtta tattagagaa tgttaattgg catatttatg aaataaaaaa accttttcca 2556601 tcgaggaaag ggtttggtct ttgtgccttt cactcttatc gctcaaggaa tcatacaacc 2556661 ttgcaacagg ttagcacctt ggttgtctca ctcagttgaa cataataaat aacagagaaa 2556721 ccggttgctg ggcttcatag ggcctgtccc tccgccagct cgggataaga gtatccgctc 2556781 aatgaaatat cttatcgtaa aagggtttgc aatgtcaata tgattcagaa gaaataggca 2556841 cctatattga gggaaaacaa tggaaatgca cacacaaaaa acaataaata gtatagacta 2556901 tttgaaaata tatgttatac taattcacaa ttagcaaaac acaaaaaacg ataaaggaag 2556961 gtttcatatg aactcagttg atttgaccgc tgatttacaa gccttattaa catgtccaaa 2557021 tgtgcgtcat aatttatcag cagcacagct aacagaaaaa gtcctctccc gaaacgaagg 2557081 cattttaaca tccacaggtg ctgttcgcgc gacaacaggc gcttacacag gacgctcacc 2557141 taaagataaa ttcatcgtgg aggaagaaag cacgaaaaat aagatcgatt ggggcccggt 2557201 gaatcagccg atttcagaag aagcgtttga gcggctgtac acgaaagttg tcagctattt 2557261 aaaggagcga gatgaactgt ttgttttcga aggatttgcc ggagcagacg agaaatacag 2557321 gctgccgatc actgtcgtaa atgagttcgc atggcacaat ttatttgcgc ggcagctgtt 2557381 tatccgtccg gaaggaaatg ataagaaaac agttgagcag ccgttcacca ttctttctgc 2557441 tccgcatttc aaagcggatc caaaaacaga cggcactcat tccgaaacgt ttattattgt 2557501 ctctttcgaa aagcggacaa ttttaatcgg cggaactgag tatgccggtg aaatgaagaa 2557561 gtccattttc tccattatga atttcctgct gcctgaaaga gatattttat ctatgcactg 2557621 ctccgccaat gtcggtgaaa aaggcgatgt cgcccttttc ttcggactgt caggaacagg 2557681 aaagaccacc ctgtcggcag atgctgaccg caagctgatc ggtgacgatg aacatggctg 2557741 gtctgataca ggcgtcttta atattgaagg cggatgctac gctaagtgta ttcatttaag 2557801 cgaggaaaag gagccgcaaa tctttaacgc gatccgcttc gggtctgttc tcgaaaatgt 2557861 cgttgtggat gaagatacac gcgaagccaa ttatgatgat tccttctata ctgaaaacac 2557921 gcgggcagct tacccgattc atatgattaa taacatcgtg actccaagca tggccggcca 2557981 tccgtcagcc attgtatttt tgacggctga tgccttcgga gtcctgccgc cgatcagcaa 2558041 actaacgaag gagcaggcga tgtaccattt tttgagcggt tacacgagta agcttgccgg 2558101 aaccgaacgt ggtgtcacgt ctcctgaaac gacgttttct acatgcttcg gctcaccgtt 2558161 cctgccgctt cctgctcacg tctatgctga aatgctcggc aaaaagatcg atgaacacgg 2558221 cgcagacgtt ttcttagtca ataccggatg gaccgggggc ggctacggca caggcgaacg 2558281 aatgaagctt tcttacacta gagcaatggt caaagcagcg attgaaggca aattagagga 2558341 tgctgaaatg ataactgacg atattttcgg cctgcacatt ccggcccatg ttcctggcgt 2558401 tcctgatcat atccttcagc ctgaaaacac gtggaccaac aaggaagaat acaaagaaaa 2558461 agcagtctac cttgcaaatg aattcaaaga gaactttaaa aagttcgcac ataccgatgc 2558521 catcgcccag gcaggcggcc ctctcgtata aaaaacaaaa gccaagagca attatgctct 2558581 tggcttgttt taattgacgg aatgcaaaga agtcagcttg tatgtaatga tggtccggcc 2558641 ttcttcccat tgaagcttct gcacttcagc tgtgcctgac ttttcgccaa actttgtttt 2558701 gcgtacatcc attggaatct ccatcggata tactcggtat ccgtccttct ctaacgtgaa 2558761 tatattttca tctatgcgaa cttcttttcc ttttgtcaca atcagtgtat taaattcaac 2558821 aggcattccc aaagtgaaat cccctttcgt tctctttttt ctttatcata acatatttca 2558881 ctgtcagcgg tttttcatcc attgtgtgag ctgccgcacg atacgccggt tttcttttgg 2558941 cgggaaataa tgtgtgaatg tactgtagta ccatgtttcc accggcttat gcagttgttt 2559001 tagcttctct tctaataaat aggaatgctg aatcgaaaca ttttggtctt tttctccatg 2559061 gattaacagc acgggagcct gaattttgtt tacttggtca aacggtgtcc tccattgata 2559121 ttcctcaggc acctttttcg gtgttccgcc gatgactctt ttcatcattc gccgcaaatc 2559181 ctgccgctcc tcgtatgtaa gaatcatatc actgacgcct ccccaggaaa caaatgaagc 2559241 tgcctgcccg cccatttcga tcgcagtgag cattcccata attccgccgc gggaaaaacc 2559301 gaagatatgg attctatcct tcttgacatt tgggtgctgc tgaagcaggc gaaaagcaga 2559361 aaatgcatcc tccctgtctt ctccggcaaa atcctcattg ccttctcctc cttgattgcc 2559421 tctgtaaaaa ggagcaaaca ccacaaaccc ttgggatgca aactggataa tccggcccgg 2559481 ccgaaccatg cccacgcttt taatcccgcc gcgcaaatat aaaaatccgt catattgtcc 2559541 cggttccgcc ggctcagcca gaagcccctt aacccgtaat ccatttgaca gatagcagat 2559601 cgtatacaaa cgcacatgct ggcttggcga cggaaatctt cttttctcta caatcaaaac 2559661 agccgcctcc ttttttctat atgctttcct tactccaaaa ttacatccgg agaacctggt 2559721 taggcattca cacattttta tacccatcat acgatatgta aagcaaaaaa ggatattaac 2559781 ttgatgcgaa ataaggaggt tgtctatgtg aacagatggt taaggctggg cttcgcctgt 2559841 gtcggcagta tctttctgat gttcgccctg gcggcttgca agcaggaaga aacgctcacc 2559901 aaagtcaaag tagctgaagt gacccattca attttttacg cacctttata tgttgctgag 2559961 tctaaaggtt tttttaagga agaagggctt gatgtcgatg tgaatacgac ctggggcgga 2560021 gataaaacga tgacatcgct tctttccaac ggctccgaca tcgcgcttgt cgggtcagaa 2560081 acatctattt atgtcgaagc gcaaggggct aaagatcccg tcattaattt cgcccagctg 2560141 actcagacag acggaacgtt tcttgtcgcg agagaagatg ttgaacactt cgactgggat 2560201 cagctgaaag gaaaaacgtt tctcggtcag cgaaaaggcg gcatgccgca aatggtcggc 2560261 gagtatgtac tgaacaaaca taagattgac ccgcataagg atatagacct catccagaac 2560321 atagacttcg ccaatattgc caatgcgttt gcttctggaa ccggtgagta tgtacagctc 2560381 tttgaaccgc aggcttctct ctttgagaaa aaaggcatcg gccatatcgt ggcttcattc 2560441 ggagaagaat caggagaggt tccttatacg acttttatgg cgaaacaaag ctatttgaag 2560501 aaaaatgaag acacagccgt caagtttaca aaagccattt ataaggcgca gcagtgggtt 2560561 gaaaatcatt ctgcgaagga catcacagat gccattaaag atgaatttga tgataccgac 2560621 ccagacgtca tcgaaacatc cattgaacgc tataaaaaac agcattcata ttcaccagac 2560681 cctctgctta acgaaaaaga atgggagctt ctccaaacca ttatggataa atcgggagaa 2560741 ctgccgaagc acattccata caatcagctt gtaaataaag aaattgctga aaaagtcacc 2560801 tcggagaaat aggaggcgcc atctatgtct ttcttacatg tcgaccatgt aacccatact 2560861 tatttttcta ttaaagaaaa aacaacggct gtgcgggata ttcatttcga tgccgaaaaa 2560921 ggcgatttca tctcatttct cggcccaagc ggctgcggaa aaacaacatt gctttccatt 2560981 attgccggtt tgattgagcc atcagaaggc agagttctga ttgaaggccg tgagccgaat 2561041 caaaaagaac ataatattgg ctatatgctt cagcaggatt acttatttcc ctggaaatct 2561101 atcgaggaaa atgtgcttct cggtttaaaa atcgccgaca cgctgacaga agaaagcaaa 2561161 gccgctgcac tcggtctatt gccggagttc ggcctcatag atgtggagaa aaaatatccg 2561221 aaagaactgt caggcgggat gcgccagcgg gctgcgcttg caagaacact tgcgcctaac 2561281 cctagtctgc ttttgctgga tgagccattt tccgcgcttg attttcagac aaagctgtct 2561341 ttggaaaacc tggtattccg cacattaaag gaatatcaaa aaacagcagt gcttgtcact 2561401 catgatatag gggaagcgat agcgatgagc gatacgatct ttttattttc aaatcagccg 2561461 ggcaccatcc atcagatttt taccattcct aaggaattgg ccgcgatgtt gccttttgac 2561521 gcccgtcagg aaccttcctt ccagacactg tttcaaacga tatggaagga gctgaattct 2561581 cttgagaaac agcaaagaaa ccattgatct gcttcacgag cagtatcaat tcaaacagaa 2561641 aaaggaaaag tggaaggtcc attcctttca gcttgccata tttattctct ttttctcggg 2561701 ctgggaaatc tccagcaggc agggctggat cgatccgctg atcttcagct ctccatcagc 2561761 tgtgtggcga ttattgctgg agaaacttgg tgacggttct ttactgtcac acatcggcgt 2561821 cactttattt gaaacggtgc ttggcttttt gctcgggacg tttatgggca cgtgcctagc 2561881 cgctttgtta tggtggtcta accgacttgc cagaatttta gatccgtatc ttgtgatttt 2561941 gaacgcaatg ccgaaagtgg ccctgggccc gatcctgatt gtcgcgctcg gtcccagttt 2562001 tatcagcatc attgcgatgg gagccatcat cagcgtcatt atcacaacca tcgttgtcta 2562061 caccgccttc caagaggtcg acgaaaacta tacgaaagtc atgaaaacat tcggcgcaaa 2562121 aaagtgggtt atttttaaag aagtcatact gcctgcatcc tcccccgcga ttatttcaac 2562181 actaaaagtg aacgtcggtt tatcatgggt tggcgttatt gtaggggaat tcctcgtttc 2562241 gaaggtcgga ttaggatata tgattattta cggattccaa gtcttcaatt ttacactcgt 2562301 cttcttaagc ctgctgatca tcgccatctt cgccactctg atgtatcagg gcgtcgagct 2562361 gctggaaaag aaatggacga aggggaggac ataaaaaacc cggcacatgt gccgggtttt 2562421 ttattcaatc catccagatt ctttcagttt tttcaagctg atcggaagaa cggaatcctt 2562481 cataataaag ctgaattttt tattgcggga aaggttctcc ggcagctcgt gaaacaaaac 2562541 cgggcctttc gtttcaaagt aatcagcctg cttttcaagc ttttctatat ctgcaaaata 2562601 tatatttttt acaatcactt tttcttttcc gagaacttta tactgtccga gatacttgag 2562661 gcttttgact ctcgcgcccg tctcttcctt tacttcccgg agcgcagcct cttctgcgca 2562721 ctccatcggc tctactttcc cgcctggaaa ctcatagcct ctgtcctcat gttctgttaa 2562781 aagccatttg ccgccaaaac ggcaaatcac ccagacatgc ttcgggctgt ccgagaaagg 2562841 ctgatcgtca aaggaaagct gaacagtatt ctgataataa tctttaaact cgtacatgtt 2562901 tatccctcaa atccgttcct agctatcttc catacatcat accacagtta cgtttcttcg 2562961 gaagcctttt atcaaaaaat aagggaaacc cagcacgccg tcaggttctg catgcagact 2563021 agctcgtaca gtttttttgc gatacttttg ccggaaagtg cgaccgacgc tctgggcttt 2563081 attatgaccc gcgaacaggg aaaagttacg gtttgcgctt aaatttattt tttaacgttt 2563141 ctaaaagatc gacaagcatc tgaggaaccg gtatgccaag agagctggct gtcacaacaa 2563201 tttgcacaga ttcataaaga atataaaaca taatagccaa gtcacgaatt gatccctgtg 2563261 tattcagcag ctgatcaaaa aagtggcata cagagatcag agccagcgtg actaattttt 2563321 tgacaagccg ggcaaatacc tttttaaatg acagtttgtg aataatggtt tccttcaaag 2563381 tcgtactgat aaattcaatt gccataagag agagcaaaat cagaaatgaa tactgaaaac 2563441 ctccaaagaa aaaacccgct gctgaaacgc tgactgctaa aaacgaaaag atgccaaagt 2563501 ctctatccat ttatcccaac atcctttcac agaaacggcc ttacgatatt ctatggtaaa 2563561 caagccgaac ggattggatt tttcagaaaa atggactggt tgtcgcctat ttttcagata 2563621 caaaaagaaa agccggacgt cttttttaag acatccggcc gttctatttt tgaacttaac 2563681 ctaggtaagc ttttagcatc cagttatgtt tttcaatatt ttgatggatc gcaagaagca 2563741 tgtcccctgt tgtttcgtca ccgacttcat cagctaaatc catgccgttt ttcagctctt 2563801 ccgcgatgac tgtgaaatca tcatatacgc tttgaaccat ttgttcagct gtttcatttc 2563861 cagcagcttc tttgacagaa gccgtttcta aggattcctt cattgttgca atcggttttc 2563921 cgttcagcgc caaaagacgt tctgctaagt catcaatata agttgctgtt tcgttgtaca 2563981 gctcctcaaa cttttcatga agagtgaaga aatctttccc tttcacatac cagtgataat 2564041 tatgtagttt cacatacatg accgtccagt tggctacttg tttgttcact gcttgaatca 2564101 attgttctga catggtatct cctccttgtt atatgactat gtataccctt aatatcgtac 2564161 gctaaaacct cttttttacc cttatctgtc acgatttctt ctattatgct acaattgtta 2564221 aaaaacggga ggtggaatgt catgacgctt ctcattacga taagtatttt gattgtgctg 2564281 gctgttttgc ttgtaaccat ttggacgact gtaaaagcct ataatgtaaa gcataccatt 2564341 gatccaccac aagaaaatca ctctgattca cacaatcaat gatgatgtga atgctcctct 2564401 tctgactgat tgctggcagc atcggcgtct ccgacttgga cttttaaggt cggcatgcta 2564461 tgctgttttt ttgctgtgac atgagattgg acagtgtata caccatcttc cttaaacgtc 2564521 gtttccaatc ggtatacgcc tttttcttgt ttcaccttaa acatttggct tgcgtctttt 2564581 tccccttctt tccatacttc aaactctact tcatcggcat ccgtcacagc ttcatcacca 2564641 tatgatacag ctgcttcata agcagcgctt tctccgggat ttactttttc aggcccggtc 2564701 agcttgacat ccaaaacctc gggcgtctca gctgtatttg ctttactttc accagatccg 2564761 catccattaa gcaataaagc agaaaaaagc agaacaacca acatcttttt catgccatca 2564821 ccctttcatc gtttacctaa atagtagcaa acgcttacag caaatggtac acaaaatatg 2564881 agacgtcaca aaaaagacct ttttgcttaa gcgcaaaaag gtcctttcta ttttagccaa 2564941 atacttttag caattcttct ttatcctgtg aaagccagaa acgcattaaa cgtttagcgc 2565001 cttccagatc atgaagcttc gcttggccgc actgcttttc attcgcagca ggtatttctg 2565061 taatctctac cgcttccttc attgtgtctt caagcagatc aacgatttcc gctgatgtcg 2565121 gctctccgct cacaactaga taatagcctg tctggcagcc cattggagaa atatcaatga 2565181 tatcaaaatg atcgtatttc tcagcgtgag aacgaatcgt aaacgcgagc aaatgctcga 2565241 gtgtgtgaat ggtgtcaggc ttcatcgcct gtttatttgg ctggcaaaaa cgaatgtcaa 2565301 atttatttac aacgccgtct gttcccactt tatgcacgcc gcaatgtctt acatatggag 2565361 caacaaccgc attatgatca agctcaaaac tttctactga aggcataatg gcactctccc 2565421 cttttttaaa aatgtaattt cattataaca tacttttccg ataagaatta ttgattaact 2565481 tttcaatctg tgtttttttt cttatacttg catcagaaag gttgctgaag aaacatgaaa 2565541 accctattca tcgctctgat cagaggatat caaaaattca tctcgcccct gacaccgcca 2565601 acgtgccgct tttatccgac ctgttcccaa tatggaatcg aagcgattaa aacacatggc 2565661 gctttaaaag gcggatggct gacaatcaaa cggattttga aatgccaccc gttccatccg 2565721 ggaggagtcg atcccgttcc tgaaaagaaa caaaaacatt aattgttata accgtttacg 2565781 ataagatcca gttttccggt tttaggatca atgactaagc catggaccgg aacgttttca 2565841 gggaacagcg ggtgatgttt aataacatct acgctgtctt tcacactcgc ttccactgaa 2565901 tcaaagcttt taaaccattg atcaaagtct acaccggagt actttattgt ttcgatgcgt 2565961 tcttccggaa tccctcttgc tttgattttt tcaagcatgc ttttgctgct gattttgctc 2566021 atgccgcaat cgtgatgccc gatcacacac acctcatctg cattcagctc gtacactgcg 2566081 acgagtatac ttctcatgat gcttccgaat gggtgtgtca caagcgcacc ggcactttta 2566141 atgattttca catcaccgtt tcgcaaattc atcgcatgcg gcagcagttc aaccagacga 2566201 gtatccatgc aagaaagaat cgccattttt ttatctggaa attttgatgt ttgatacttt 2566261 tcatactctc tttgttcagt aaatgtcttg ttaaattcga gaatatcatt tagaagactc 2566321 atgttcgttg tccctttcta ttctttttac tcttcaatat atcacaaccc ttgtttattc 2566381 gtcataataa aaaaagacaa accctcaggc ctgccttatt tccccatgtt atagcgtttt 2566441 ttgaactgct caactcgtcc gcctttttca ttgaatttct ggcggcctgt ataaaacgga 2566501 tgcgtgtcag agcttacctc tactttaatg acaggatatg tgtttccgtc ctcccactct 2566561 gctgtttcat tagatgtttt cgtagaggtg cttagaaaac ggtagccgct gttgacatcc 2566621 tgaaatatca ctttgtggtt ctttggatga attccttctt tcatgggtat ctcctttcaa 2566681 taaatcgtaa taattacgtt ttattttata accttacaaa cgttttgtca atcttcttat 2566741 atccttccct ctgtttcaca tcgtaaacct catggcattt aagaatagga agaataatct 2566801 aaccgaggaa gcaaataata aacccaaaat acatacagaa cgtctttttg gaaaggtggt 2566861 ttacgattgt ggatgattta gttttggcca gaagcctttt tggcacgacg atgggctttc 2566921 atatcatttt cgcaacactt ggagtcggtc tgccgctcat gattttagtg gcggaattga 2566981 tctatcaaaa aacgaaagat gaccattatg cgatcatggc gaaaagatgg acgaaagcac 2567041 aagccgtttt gctgggggtc gccataccga ccggaacgat cgcgggcact cagctcgcgc 2567101 ttttatggcc gggatttatg gaagtcatcg gccgggtgat gtccctgcca tttcaaattg 2567161 aaatctatgc tttttttgtt gaagccctat tcatgtcgat ttatgtatac gctgcagacc 2567221 gtttgtcacc tgcaatgagg attgttgctg ttttctttgt gttagtcggg gcagcagcat 2567281 ccgctgttct gatcacgaat gttcacgctt ttgaaggtac gcccgccggt tttaaaattt 2567341 taaacggaaa aattacagat gttgacccgt gggctgcgtt ttttaatcct agctttttta 2567401 tcactgccgg ccatgtcgtg ctgtccgcgt ttatgactgg tgcgtttatc gtggcttctg 2567461 ttgcggcgta taaaatgatc cgaacgagga aaaaggaaag ggtctatcgc tttcaccgga 2567521 aagccctttt gctcgcactg acgatcggcg gtattttttc attgctgacc gctttgaacg 2567581 gacacgaatc tgcacagatg ctgtacgaat accagcccga aaaattagcc ggtgcggaag 2567641 gcctatttga aacaagatcc cacgccccgc tcgctatcgg cggttttacc gacccgaatg 2567701 aagaaaaagt aaaatgggca atcgagattc catgggcttt aagctttttg gcagcgaacc 2567761 gttttgacac tgttgtaaaa ggattaaatg catttccgag agatgaatgg ccgccgcttt 2567821 tcattcacac gctgtttaat gcgatggttg gtgtaggcat gctgctaatt ctttattcca 2567881 ttatcggtgt ggtctggaga aaggtgctca agaaagaccg tttcccaacg tggcttttga 2567941 tcattttcat gacagcaggc ccttttagtc tcatcggcat tgaattcggc tggattttcg 2568001 catgtacggg gaggcagcct tgggtcatct atcatctgct gaaaacgtca gatgtcgtaa 2568061 caacgactgg ctcgatcggg gtgctgttct tatttttcac atttgtttat gccgtgttag 2568121 gcgcagctgt cgtctacgtg ctgctgtatt atttccgcaa gcacccggtt gacgaagatt 2568181 taaatacagc ggagtcgtaa tggctccgca aacaggaaac caaatggaag gaagatcgta 2568241 caaatggaga tttcaactga cgctctgatc gccatctcaa ttatctgggg ctttgtgttt 2568301 atttacgccg tcatggcgac aatggatttt ggagcgggat tttggtctat gatctattta 2568361 aacaaggagc atatgaaggc caccgatatt gcgaatcgct ttttgtcccc gacttgggag 2568421 gtcacaaacg tctttattgt ggccatcgtc gtggcgcttt tcagtttttt ccccggcgcg 2568481 acatttgtgc tcggcaccgt tttattaatt cccggaagca tgattttgct gcttttagca 2568541 attcgaagcg gatttctcgt gttttcaaat acagcaaagg agcggaaaac gctaagatat 2568601 atttccggca tctccggctt tatcattcct gctattttaa ttttggtgct tcctgtgaca 2568661 cacggagggt ttatagaaaa aacggatgga atctataact taaatatgtc taaaatcttt 2568721 tcaagcccca acgcctattc atttatcggg tttgcgattt taagcacctt atttttgtcc 2568781 tcgctgttgc ttgcagattt ttcaaatgtg gcagaggaac aggatgcgta ccgagcctac 2568841 agaaaaagcg ccctgattac cggcccgatt tcactgttgt ttgctgtatg cattatggta 2568901 actatgcgga atgaagcaaa ctggctgtac agcggaatga tgaatgattt ttcttggatt 2568961 attgcatcgt tcattacatt tgtcattgct ggaatcgctc tttttctgcc taacaaaagc 2569021 tttggtcaaa acatcggaaa accgcgtctc gcacttgttg cgattgggat acagtatttt 2569081 ctcgcaagct acgcgtacgg gcgggcgcat cttccgtata tgatttatcc cgatgtgaca 2569141 gtcatgtcag gcttcacaga gccagcaacg ttcagagcgc tgtttgcaac gtatatcgtt 2569201 gcatttatca ttctatttcc gggcttcttt ttcttctgga aaatgtttat gcgagataaa 2569261 cgctatatcc gccaggagga atagagggca agccagccgg ctatactaat ccagaacctt 2569321 tataaggagg ggatggcatg gagcagaaaa ttctatgtga ggtcaacaac tgttcttatt 2569381 ggggcaaagg taacaaatgc accgctgatg ccatttatgt tgtcagccat actggtgaaa 2569441 cggctgaaaa cagccgggaa acagactgca aaacgtttaa gccgcatgat ttataattaa 2569501 aagaaagagc tgcatcagcc agctctttct ttttgcatgt tgagtgttct cagcttttta 2569561 gttatgaccc cgtttgcagg tgaaaacaaa aaggcgcttg cataacatac acctgtcatg 2569621 gccgccatcg ctcctgaaat cgaaacatta agccacgttg cgaagaaata gcccatgacc 2569681 gccgacagcc cgccaatcaa cgcgctgaga atcagcatat aaagaagccg gtctgtcagc 2569741 aaatgtgccg cagccggcgg aacaatcagc atggccacaa ccaatacggc acccaccgaa 2569801 tcaaaggaag caacagtcgt caaggacagc atgcccattt gcacgtaatg aatgagcaaa 2569861 accggtattc ccaaggctaa agccatttga ggatcaaacg aagcgatttt aaactcctta 2569921 tagcacacac tgatcaacac tacgtttaaa accagaacag atgccagcat ccaaaacgct 2569981 ttcggcccaa tatcaacccc gaataccgtc accgtattcc acggcacaaa agcgatttct 2570041 cccattaacg agtgctcaat atcgagatgg acattcgctc catacacaga aagcaaaata 2570101 accccgattg caaataagga tgtaaacaca actcctatgg cagcatctga ttgaaccccc 2570161 ttgctatgaa gaagctgaac caagaaagcc gttaacagac cggttgcggc tgcgccaata 2570221 aacatataaa tcccatcgag acttcccgtc actagaaaag cgccgacaat gccaagcaac 2570281 actgtgtgac tgattgcgtc ggccagcatc gccatgcttc tcagcacaag aaatgtgccg 2570341 atcaatccgc agcttacacc gactaataca ccggtagcta taatccatgc ttcaaaactc 2570401 atttgcgatc tgtcccttct cggcatcatg agacgctttt cgacgctcag gcatccgtcc 2570461 atacagcttt aagagtgaat aaagccgctc tctcgtttct ctcggtaaac ggtccgggtc 2570521 aaagtagtcc tgatcggatt ctatattggc aagttccatt tcatgcatga gatacacttc 2570581 atacatccgc tgcttcaaag ctgtgtgata gcctttttct atccctttgc ttgtgatttg 2570641 ccaaatccca ttttcgatac gctcaatgca cctctcttgt tccaagtcat ttaatgcctt 2570701 aaggcataat gaaggggata ggcgtctttt ctttcttaca ctttcaacag ttacacaaag 2570761 attattcttt tcatactgtt cataaatcgc caaaagcact tgctccctgc ttgttctgcg 2570821 ccgcagcctc atcagcctta tggctttagc agccaatccc cgcttaggcg cgcaaatcat 2570881 tgaaaaaaga aagagcagcg ttgcagataa gatcattaat ggccctgtcg ccattccctt 2570941 catcgtggtg ctaagcaggg ttccggccac tccgctgacc ccgcctgtaa tcccggcaat 2571001 gatgatcatc ccggttaatc gttcggtcca atatctcgcg gttatggcag gtgtaatcag 2571061 catagccgcc attaatatca caccaacagt ctgaagccca atgacgacag cacagacaat 2571121 cagacaagcc aaaagcccgt ttaaaaaacg caccgggatt cctaatccct ttgcaaacgc 2571181 gagatcaaaa gtaatcaatg taaattcctt aaagaaaaca atacatagga gcagtagaac 2571241 agcggatatc cctgcaataa ggatgatatc ctgcctgacc aatgaagcag cctggccgaa 2571301 taaaaaagaa tcaagcccgc tttggcttcc cgccccctgt tgctgaatat atgtcagcag 2571361 aatgatcccg acgccaaaaa acacagaaag aacaatcccg atcgccgagt cctcctttgt 2571421 ttttgaaagc cgaggaatca gctgaataca aaacgttccg agcagtccgg cgagcgctgc 2571481 ccccagcaaa aagaaaggca gtgatttttg cccggtgaac agaaaagcga gacacactcc 2571541 cggcagagct gaatgggcca tcgcatcgcc gattaaactt tgctttctca gcagcacaaa 2571601 gctgcccaaa acaccgcttg ccgtcccgag caaaagcgta ccggccagca cccactgtgt 2571661 attcggatgc tgaagctgca gccacaaact ttcaaacatt gcgctcactc cttatgtcct 2571721 tctgccagca ctttatcttt taaaaacgta agccttcctc catatgtttt ttgcaggttt 2571781 tcgatcgtaa aaacgttttc cgtcggtccg aaagcgattt tccttaaatg aagcagtaag 2571841 atccaatcga aataatcctc ggcggtctgc agatcatgat ggacgacaag cacggttttt 2571901 cctttttctt tgagttctgc caacagcgtc ataatcgcgc gctccgtcgc tgcatcaaca 2571961 cctgcaaacg gttcatccat aaaataaatg tcagcgttct ggcagagtgc ccgggcaaga 2572021 aacacccgct gctgctgtcc gcctgacagc tggctgattt gccttttcgc ataatcatgc 2572081 atcccgactt ttgttaatgc ggccttcgcc atctccacat ccgctttctt tggcctcttt 2572141 aataaaccga ttctcccgta tcttcccatt aggacgacat cgagcgggct tgtggggaaa 2572201 tcccagtcaa ccgagccgcg ctgcggaaca tatccgattc tggtccgctg atccttatag 2572261 tctttgccgt aaatagagat gtctccggaa gctctgggca caagaccgag aatcgttttg 2572321 atcaaggttg attttcccgc gccgtttggg ccgataatgc caataagttt tccttcaggc 2572381 acctgcagcg aaatgtcctg cagtacaggc tttttatgat aagcaaccgt cacattatca 2572441 agctcaacag ggaacatatc ctccacctct tttctttatt taagcgcttt agtaatcgtg 2572501 ttgatattgt ggcggaacat tccttcgtat gtgccttctt ttgtgccctt ttcacccatg 2572561 gcatccgaat aaagctgacc gccgattgtg actgtatggc ctttttcttt agcgccttcc 2572621 accactgcat tgattgattt ttcagataca ctgctttcta cgaacacagc ttttatttgt 2572681 ttttctgtca gaagatcaac cagctcctga acatccctta atccatagtc cgaatctgtg 2572741 ctgagtccct gcaggccttt taccttaaat ccatactcat tcccaaagta cgcaaacgca 2572801 tcatgagcag tcacaagcac acggcttttc tccggaatat gtgcgatctc cttacgcgac 2572861 cacttatcta aatattgcaa atcttctttg tactctttgg catttttccg aaaggcatct 2572921 gcgtgctgag gcattgcttt gctgaattgc gcttcaattt catccaccgc atagatccat 2572981 aacggaatgc tgaaccagac gtggggatca aacgtcttgc cttcccccgc gggaataagc 2573041 ttatttttcg gaatggcctc agctactgcc gccgattgtt tttgttcgcc gattttttgg 2573101 aggacatcct ccattttccc ttccaaatgc aacccgctgt acagaacaac atcggcagac 2573161 attaattttt tcgtgtcacc ttgggaagct ttgtaaaggt gcggatcaac ccccggtccc 2573221 attaaagagg tgacttttac gtgcttacct ccgatgtttt ctgctgcatc ggcaatttga 2573281 gatgttgtcg ctgtcacttg taattgctga tcagcgcttt ttccggctga atccgttccg 2573341 catcccgtta aagcaaaggt cgcaaaaagt actgctgcca tcagcccttg tctcatattt 2573401 ctcctcctct ttgccatcaa tgtccgattg ttttatctta tgttgtcagt tcttagacat 2573461 gtgacattaa attagccaaa agcatgtttt atttacacag gacaaaaagt ttccctcatg 2573521 caaaattatc gcgtttggcc atttttgtca agctgattta cataaaaaaa ccggctgggt 2573581 cagcagccgg tccaaacgag aagggatgta ttcaacgaac acttttactg taacagcaca 2573641 gtgtcattta ttcaaaatag caaaatgctt ttttcttaac catgctgtgt gaaaacatcc 2573701 attttggtca catattttcg cataatatct tggtttacct caacccctaa accaggctgt 2573761 tttgacacag aaataaatcc attatcaata cgaatatcag gagttacaat atcttcatcc 2573821 caatagcgtg aggatgaaga tatatcgcca ggtattgtga attgaggcag tgaagcaagc 2573881 gccacgttct gcgctcttga tatgcctgtt tccagcattc ctccgcacca aacctgcata 2573941 tgatgctctt tgcataaatc atgaattttt aaggcttctg ttaagccgcc gacacgagaa 2574001 ggttttatat taataatttt gcagcttcct agctcaatcg cccgtctcgc atcatcaact 2574061 gaacaaatgc tctcatcaag gcaaatggcc gttttcaaat gtttctgcaa gtggcggtgg 2574121 tcaacgatat cgtcagcttg gagcggctgc tcaatcatca ttaaatgata gtcatcaagc 2574181 tcctttaaac ggctgatatc cttcagttcg taagaggaat tggcatcggc cataagcggg 2574241 atggttggga atcggctgcg gatggccttg accaattcca catcctgccc aggctgaatt 2574301 ttaattttta ttctttgata accttctttt tgatagctct caatttcctt cagcatatcg 2574361 tcaagaggcg ccaggccgac taccaccccg gcagggactt tatctcttgt tccgcccaat 2574421 gcctcagcaa gggatacgcc cttctttttg gcataaatat cccatacagc cgattcaagt 2574481 cccgcttttg ccatccggtt tcctttatac cgcgccaggc tgtccggcac ttctgaaggg 2574541 tgattgaatt cacggccgac gacatttggg ataaaaaaat cttttagcat atgcaaacat 2574601 gttccaatgg tttcctcggt gtaccaaggc gaagagaaag cggaaacttc tccccagcct 2574661 gtgacacctg atgtatcaat ggcttccacg atcagaaatt tacgctcttg aagcgtttcg 2574721 atactgtttt taaacggttt ctttaagttc atgctcaaat ggtaaagcgt gattttttct 2574781 atttcgatca tagcagttct cctttacgcg catccttcag ctgatttcgc aagagcttat 2574841 tagacgcatt gcgcggcagg cggtcaagca caaagaattt tgccggaatt ttatacttcg 2574901 ccaagcgttc tttgcagtag tcagtcaatt ctcctgcgct cacaggcttg tgaaggacaa 2574961 gataggcgtg aggcactttc ccccattttt tgtcctcagc ccctgaaacc ccggcttcgg 2575021 ccacagcggg gtgtgaaagc agcactgact ccacttcggc cggataaatg ttttctccgc 2575081 cggatatgat cagatctgaa cgtctgtcta atacatataa aaagccttca ttgtccaaat 2575141 aaccaagatc acctgttttc agccagccat tttgaaagga ggcttcgttt gcgctctccc 2575201 ggttaaaata gcttttcatg acattcgggc ctttgaccat gatttcaccg tgttcatacg 2575261 gttcacatac ctgtccgtcc cgctctattt tgatttcaca cgaaaacagc ggtttccccg 2575321 cagatccgag cttttccatg ctgaattccg gcgacagggt aacaatttgc gagcatgttt 2575381 ctgtcattcc atatgactga aagacaggga atcctttctc acggcattcc tcaagcaatg 2575441 gcagcggtgc aggaccgccg ccgagaagaa tgcatctgat ggattcaggg cagcggtttg 2575501 tttcttccaa aagactggcc agcatagtct gcaccgcaga tatcattgtc acttcatgcc 2575561 tgttgataga atgcagcaca tcgcttacgg aaaaacgctg gtgaagcacg acagtcattc 2575621 catagatcac agatttaaat aatgcggaca atccgctgat atgaaagagc ggcaatgcga 2575681 taagccagcg gtcttgttct gttataccca aattaagagc ggacgacacc gcactgaaat 2575741 aatggtttcc gaacgtttgc tgaactccct tgggctttcc tgtcgtaccc gacgtataca 2575801 tcagcgttgc cgttgcatcc atttgcatat aagcctcgat ctcaatttcc tctgctgctt 2575861 ctttcatcag ttcatccaca tcaatcgttt gaacgatgtg ttcatattct ttcttctcaa 2575921 agcttgaatc tgtcaataaa aagccggatc ccgaatcctc cagctgaaac agcctttcat 2575981 gtgttgacag cttcgtattc aaaagcaccg ccttaacacc aagcaaaaaa caagcgtgaa 2576041 cagcgtatac catttctgca cggttttgga gcaaaatagc tgcagtatcc cctttccgaa 2576101 ccgaatgagc ggcaagctgt tccgccattc gtttagacgc ggcaaacaat tctgcaaatg 2576161 tcacggtttg gtcttcatag atgagagcga ttctctcagg tgtcagctgt gcccgctgca 2576221 tgagccagtt gggctgttct gtcagcatgt catcatctcc gaggtaaaat gtctgtattg 2576281 aaaagaaaac agcttggacc gcaaagtctc aagctgttgg tttactagat attgctgatc 2576341 acggaaaacg agggaactgt ccgaaatcag gtttgcgttt ttccttaaag gaatcacggc 2576401 cttcttttgc ttcatctgtt gtgtagtaaa gaagggtagc atcccctgca aactgctgaa 2576461 ttccagcaag tccgtctgtg tccgcgttaa acgcagcttt aagaaagcgc agtgcggtcg 2576521 ggcttttttc aagcatttct tcacaccatt taatcgtttc ttcttcaagc tgttccaaag 2576581 gaacgactgt gttgacaaga cccatgtcca gtgcttcctg tgcgttgtac tgacggcata 2576641 ggtaccagat ttcacgtgct tttttatgtc ctacaattcg agccaggtag ccagaaccgt 2576701 aacctgcatc gaagcttccc actttagggc ctgtttgtcc aaaaattgcg ttgtccgcag 2576761 caattgtcaa gtcacatacg atgtgaagca catggcctcc gccgatcgca tatccggaca 2576821 ccatcgcaac aaccggtttc gggatgacgc ggattaaacg ctgaagatcc aatacgttaa 2576881 gacgagggat ctggtcgtct cctacatatc caccgtggcc gcgcactttt tggtctccgc 2576941 cagaacaaaa tgctttgtcc cctgcaccgg caagcacgat aaccccaacg ttttggtcgt 2577001 ctcttgcgtc agcaaacgca tcaatcattt cagcaaccgt tttaggggta aacgcattat 2577061 gtacctcagg tcggttgatt gttatttttg caatgccatt atacgtttca tacaatatct 2577121 catcgtatgt ccgttttgtt ttccattcag ccatatgatg acctcctttt attctctatg 2577181 tgaatgagtc agatgcttgt caaaaactca ctcactattt taccaaacaa tcgcggctgc 2577241 tccacatgga ccgtatgtcc tgcttttgga acaatctcta ttctactaga aggaagcatc 2577301 ttatgcacct cttgattgat ggcgcaaaat ttttcgtccc actccccgca gatcagaagc 2577361 acaggaacat ctatttcctc tacacggctc cacaaggaag gctgtgaacc ggtgcccatg 2577421 ccggttaaac tgttcgcaag cccaatctta ttgttccgca gacggcccga tcgtatcctg 2577481 taccgaatat cttcagccag cctctgctga gatgaaaaca aagggatatt ctcccaatac 2577541 gcaacaaacg cttcgagccc gtctcgtaaa ataaaatcag caagcttccg gtcccgcatg 2577601 attcgttccc gccgttcccc aagtgttttg agccccggcg tcgtgctttc aagcacaagt 2577661 gccgataccc gctcgggata tgtcatcgca aaagagtaag caagccttcc tcccatagaa 2577721 tacccaatca atttcacttt gtgaagtttt aattgatcaa aaatctcggc aaggtcagaa 2577781 acttgccggg ttgtgctgta tcttttccca ttcagcgggg catcggtttc cccatgccct 2577841 aaacaatcaa ttttgatcaa acgggaatca ggcagcattt catcaagaaa agtccatgat 2577901 tgtttgctgc cggtaaaccc atgcagacag acgacggctt cggaagcatt cggtccctcg 2577961 tctgccactg catatcggac accatctgat accgttatgt ttacagttcc cattgttttt 2578021 tcacttcccg cacagcctca ttcagcatat cgcgatgaag ctggactctt gattggcgat 2578081 ccgttttgat ttcaatcaaa tggagtccgg gcttgtctgc ctgcggcgcg taagctgttt 2578141 tgaattcatc ccaagaagcc gggcatgaat acgttccgcc gtaaagtgca gccgcatgct 2578201 tgaaatcgag ccctgtcggt gtgccgaaca aatcttcaaa gtgtgtcttc tcagaagcct 2578261 gcggcaaaaa ggagaaaatc cctcctccgt cattattgac aagaatcaca gtaagaggaa 2578321 tacccagctt tttggccgcc agcaggccgt ttaaatcatg ataaaaagat aaatctccaa 2578381 tcacaagggt aacaggcgct tttgttcctt cacatacccc catggcagag gagacgacac 2578441 cgtctatccc gtttgctccc cggtttgaat aaatccggaa agggcggtcc tgcttttcaa 2578501 aaaacgtatc aacatccctg atcggcatgc tgtttcccac aaacagcgag ctgttttcag 2578561 gcacaagatg ctgaaggatt cgatagagat tgccttcaaa cgaaacatct tcactgctga 2578621 ttgtttgcag atgctcgcgg aaccgcccat tgacaaactg ccacttttcc agccactctg 2578681 aggatctggt ggcagcagta aggcctgcca tgatctcctc agcaaaaaca gacgcattac 2578741 aatgaatcat atgcgcgctt gcctgtgtcg ggtctctcca ccctccatcc tcgtcaatca 2578801 cgatttgctg aatcgtcgga tcatccttaa gccataagaa aaccggtttt gaaacaggca 2578861 tcggtccaaa ccgaatgaca acatcaggac ggagtttccg cttcagctca tcatctttta 2578921 aaaacgaatc atacgcatca ataacagtgc ttttatcatg aacaccattc cgcagattag 2578981 acagcggatc tgctaaaatt ggatactgaa gcgcttttga cagcgcaata atgttttcct 2579041 tgtccgcatc actatggagc tctccgcaga cgatcattcc tttttcagcc tctgcgagca 2579101 tctcagccac atcagacagg gactctcggt caacagactg cgtacccgtt ttcacagaca 2579161 catgacggcc tgttctcatt cttccaaacg gctcatctga aagatccggc atcagcggtt 2579221 cgcgcagcgg cacattcaca tggacaggcc ccatcgggcg cttttgtgct tctccggcag 2579281 cgcggcttgc cagcgttcgg atgtatctca gcatttgcgg agactcttca ggaagagcag 2579341 agtctgtgaa aaacttaaca aagttaccga ataagaagtg ctgattaata gcctgcggtg 2579401 cgcctacttc gcgcagctca tgaggccgat cagcagttaa cacaataata ggcacccttg 2579461 aataatgggc ttcaaccaca gccggataaa agttggccgc ggctgttcca gatgtacaga 2579521 tcaatagtac gggacgctgc ttcgcttttg ccaaacctaa tgcaaaaaat ccggcagacc 2579581 tttcatcaat ttggacatgg acgctgatat cgggatgcgc agcacaaaga acagccagcg 2579641 gtgtagatct tgagcccgga caaacgacgg cgtccgtaat tccggaaagg gcgaattcat 2579701 caataaaact tccgatgtaa tgagtaatcg ggttgactgt caacgcctct cacctcctaa 2579761 tgcagagatc atcggcttca atttaatctg tgtttcttca tattccgaga ttggttccga 2579821 gtcttccaca ataccgcacc cggcaaacag ccttgctgtg cttccttcga tgagccctga 2579881 acgaatggcg accgcgaatt ccccgttatc ctggctgtca atccagccga taggggccgc 2579941 ataccagccg cgggacatcg gttcaatctc cctgatcacg tcaacagctt tttcctgagg 2580001 tgatccccca agcgcgggag tggggtgcag cttctcaatt aagtcaaaaa tcgaagcaga 2580061 ctcgcgcagc tgtccgacaa tcggcgtaaa caggtgctga acgctttttg ttttgtacaa 2580121 aacaggtcca tcaggctttt caacctctga acagcttgat acaaaagcat tatgaatcat 2580181 acctaccaca atatcatgct caagcaggtt tttctcatcg tttaataatt caaggcctat 2580241 ccggcggtcg tcttcttcat tcacgcctcg tttaatggag cctgccagac aggaagacat 2580301 gacagtgccg ccgtctcttt tgatcagtct ttccggagac gcgccgacaa aggttttgcc 2580361 ttcttgttca attgcaaaaa catagcttgt ctgctgatcg tccagaagcg ttttaagcac 2580421 cggttcaatt tggattggac cgtcaaacgt gagcagcagc tctcgggcaa gaacaacctt 2580481 atcatattgt ttctctttaa tttggcttgt ggccgtttcg attgctttca gccaatcatc 2580541 cttatccagc tcttcggctg ctgcaatcac agcctgatct tcttgcttga aatcgggaac 2580601 cataaattcc gccgcaaaag cttttaagcc ttctaaaaca gcttctgcgt cttctcctcc 2580661 gcttacccat ctgttaactg ttaagaacgg gccttcagca gtcatcgtca gcataagcgc 2580721 aggcacaaag aaatcccctt ccgagaaatg gtcccattgt gaacctcttt cttcgcaagg 2580781 gtcaaaagaa aatcctccga ataacacagg tcccactgca gaatgctgca gcttttcttc 2580841 ttcataaata tgaaaagccg tctttttaaa gcgctcccat tgttcaaaaa cctcacgata 2580901 ccgctcgctg tttttttgat ttgtctggaa aaccgcttct ttgccaagac cgactattgt 2580961 caattcactt tcaggatctg accaaaaaaa tcgattgcct gtatattttt ttgctccgta 2581021 attgaaaaat gatagagggt caagagactc gatttgtctc gaatagctta ttaagacagc 2581081 atggttgact tctttggctt tatgtaatgc atgtagaact tcctttcgga acgtacgctg 2581141 caccgttgtc accatgagac attcctccat aatccttaaa atgcttttaa taccatacac 2581201 ctgtgtctcc tttgtgtcaa acacagatca tgcagtccaa atggcctgcc ttacctatta 2581261 taaacctaat ttcagaaatg aaaaagaaac aaagcttaaa tttctttctc cactgatagc 2581321 aaaggttgta tccgcttacc ataaaaggaa aacctcctat attcctccac ccgccattta 2581381 tgaaagttct caggcgatct gttcatacta aaggtatgca tcacagagaa acgaggcgat 2581441 cacattgctt acgaaagaac agcttcagca tttaaaaaat gaactggaac aaacgaaaaa 2581501 agatatctta aaccgtttca aagacaatga tcattttcag cttaactcag cctttcctta 2581561 tgattcgtgg ggtgagcttt cggcatacga caaccatccc ggcgatcagg cgacagaact 2581621 ttacgagcgt gagaaagaca tcgctctaga cttgcatgag agagagcacc ttcgggacat 2581681 tgagcattca ttgaaggcga tagaaaacgg tacgtatggc atttgtgaag tcagcggaaa 2581741 ggaaatccct ttcgaacgac ttgaagcgct tccgactgcc acaaccctcg cggagtattc 2581801 gtcacaggac gtggtttcca aagaccgtcc gattgaagaa gaaacaccat tcgggcaatt 2581861 tgaatttgat gatgatgaag aaatcagagc gccatatgac agtgaggatt cctatcagga 2581921 tgtcgaaaaa tatgggaact cacaaacgcc gcaggatatg gaaaaccctc cgctcagcta 2581981 tgatgatatg acgatgaatg ccgaagagaa tatcggcaat acggagtctt acgaaaattt 2582041 catcgctaca gatatcactg ggaaagaaat taccgtttat caaagcagag cccatgagcg 2582101 ctatgaagaa gaacttgacg aagagggaat catgaccaca ttcggcgatc tccacgctga 2582161 ttgaaccccc aattattggg ggttcttttc cgttttcagc atatcgtaaa tcagcttcag 2582221 ataatccttt tgcaggccga tgtcataccg ctcgccctct agcaatttcc cgtatacggt 2582281 acatgccccg agcgaagctt ttatcgcatc cgttacctgc acttctcctc cgctatcagc 2582341 ttctaatgcc tccagctcat taaaaatatc cggtgtgaaa atataacgcc ctgctgcggc 2582401 aaaatgagac ggagggtttt gtttaggctt ttccacaata tcctgtatgc gataaagccc 2582461 tttttcaaca ggctcccctt ttatcacccc gtaatgatgt aaatcctccg tttttgtttc 2582521 ttttaagccg atcacactgg actgatattt cgtatacgct tcaatcagct gccccaaagc 2582581 cggctgattg gcggaaaaaa tcagatcatc tggcaaaacg acggcaaaag gctctcctcc 2582641 tgcaaattgc tttccgaaag aaatggcgtc gccaagaccc tttgcataag gctgccgcac 2582701 atagtgaatc cgtatatccg gaatgggatg ctctctaagt aaatgcagtt tattcttaga 2582761 ggccaaaaaa gcctcaagtg ccaaagagga atcaaaatag tcgacaatca gatttttatg 2582821 gctcgataca accatcaaaa tgtcctcaat gcctgactcc tttaattctt caacaagata 2582881 atgaatcaca ggcttagatc ctaccggaaa catttctttc ggaatcacct tcgtcaccgg 2582941 cagatttctc gtgccgaatc cgcctgcagg aatgatcgct ttttttatca tggtattttc 2583001 ccctcagctc atgtttatta catgatattc caagagcgca tcccgatgtt tgtacatctg 2583061 aaattaggcg gaagcaactg ggcagaaagc ggaatcacga accagccctt ttttaatagg 2583121 atattgatat atgaccagta atcttgtaaa ggagctcagg tgatgaaaat ttgtgtggtt 2583181 ggcgccgggt atgtcggttt aaccctatca gcggcactgg catccatcgg acatgacatg 2583241 atatgcacag acaaagacgt caaaaaaatc gggcagctga aaaaaggagt cattcccttt 2583301 tacgagcctg ggctttcaga tgcaatactt cgttgcggca atctctcgtt ttcttctgaa 2583361 gtgaaatcga gcatggagga atgtcccgtt atttttatcg cagtcggaac tccgccgcgt 2583421 tcggacggat cagctgatac gaaagccctg cagtccgtca tcggtgattt aagcgaggcg 2583481 atccgatcgt ataaaaccat tattacgaaa agcactgttc cgcccgggac aaatgaaaac 2583541 atagcaaaac agctgattgc ctccggagtg tctaaaaacc tctttaatat cgtatccaat 2583601 ccggagtttc tgcgggaagg caatgcctta tatgacatgc tgcatcctga caaaacagtc 2583661 atcggtgttc aggaagaaga tcacgtatcg gcagccatcg tcaaatccat ttacaaacac 2583721 attgataccc cttttatcgt tacaagctta gcgggagcag agctgatcaa atatgccaac 2583781 aatttctttt tagcggccaa aatttcgttc attaacgaaa tggcccgcat atgtgaagcc 2583841 tatcaatcag atatctcaga tatttcccgc gctatcggtc tagacccaag gatcgggaag 2583901 cactttttgc aggcaggcat cggatacgga ggctcttgtt ttccaaagga tctgcaggcg 2583961 ctgcaatttg ctgcccagga aaaaaacacg gagaccttcc tgctccgggc cgtgcagcac 2584021 attaatgaca cccagcttgg cctgtatatc aaaaaaatac agtcattctt cgaaacactt 2584081 caaggcaaga aagcggctgt actcggcatt tccttcaaac cgaatactga tgacatccgg 2584141 aattctcagg ctgtcagact gatggaaagg ctggcggagc tgggatgtga tgttcatgca 2584201 tatgatcctg aagctgtact tccagaacat ttgcggcaac atgtaactca gcattctcaa 2584261 gcttttgatg cgatcgaaga gagtgacttt ttatttttgg cgacagaatg gtctgagttt 2584321 ttagcgtttg attggaaaaa ggctgcagat atcatgaaag ggcgtcttgt gattgacgga 2584381 cgcaacgtac taaaaaaaga actgatcgag gcttgcggcc tgatctgtac gggagttggc 2584441 cgtccatgaa aatactcgtc acaggagcag cgggctttat cggctcccac ctctgcgaag 2584501 aattactaaa agataagaaa cataacgtta tcggaatcga tgactttatc ggtcctactc 2584561 cattttcctt gaaattaaaa aaccttaaaa acctgctgcc ggaaaagcga tttacgttca 2584621 taaaggaaaa tctgctgaca gccgatcttg cttccttact ggaaggagtg gacgtcatct 2584681 ttcatttggc ggccataccg ggtgtccgct caagctgggg caatcatttt cacccatatg 2584741 ccgcacataa tatccaagcg ctccaaaggc tcctcgaggc gtgccgggaa cattctattc 2584801 aaacgttcgt ctttgcatcc acctcttccg tctatggcga aaaacaagga aaagtcagcg 2584861 aaaacacgtc gctttctcct ttatctccgt acggggtaac aaagcttacg ggagaaaagc 2584921 tttgccatgt gtataaacag agctttggca ttccaattgt gattctccgt ttttttaccg 2584981 tatacgggcc aagacagcgg ccggatatgg cttttcaccg gctcattaag cagcaccttc 2585041 agcaaaagcc gcttaccatc ttcggtgatg ggcagcagtc aagagatttc acttatatca 2585101 gcgactgtgt caaaggcatc accgctgttc ttgggaaacc ccaccttatt ggtgaaacag 2585161 taaatatcgg cggcgcagag cgtgcctcag tcttaaaagt tgtctccctc attgaggata 2585221 tttccgggag aaaagcaaca ctgcactttt cggacaaaat agcaggggaa ccgagcaaca 2585281 cgtgggcgga tatttcaaaa gcaaaacagc tcttgcatta tgatcccgcc acatccttaa 2585341 aggatggctt gaccaacgaa atcgcctatt tatcgtcgct gtatcagggg gaataaaaat 2585401 gaagcttgcc tttatctgta cagaaaagct gccggcgccc gcagtacgcg gcggcgctat 2585461 tcaaatgatg attgacggtg tcacgcccta tttcagcagc aggtacgacc tgaccatttt 2585521 ttcaatagaa gatccatcgc tcccaaaaag agaaacaaaa gacggcgtac attatatcca 2585581 tctgccaaaa gaacattacc gcgaggcggt agccgaagag ctgcgagcct cttcctttga 2585641 cctcattcat gtgttcaaca ggcctttaaa tgtctcttta tataaaaaag cctcaccaaa 2585701 cagcaagatc gttctgagcc tgcataacga aatgttttct gaaaaaaaga tgaccttcgc 2585761 gcaaggaaaa gaagtactcg acaatgtctc catgatcaca acagtgagcg aatttattaa 2585821 acaaaccgtc attgaacgtt tccctgaagc cgaggacatc acaaaagttg tgtattccgg 2585881 cgttgattta aactcttatc cgcccgtctg gacgatgaaa ggctcggctg tcagaaaaac 2585941 ataccggaaa aaatacggta ttgaagataa aaaagttatt ttattcgccg gccgcttaag 2586001 cccgacaaaa gggcctcacc ttctcattca cagcatgaga cggattttgc agcagcaccc 2586061 tgatgctgta ctggtcatag caggcgggaa gtggttcagc gatgacagcg aaaaccaata 2586121 tgtcacctat ctgcgcacgc tggcgctgcc atacagagac cacataatct ttacaaaatt 2586181 cattcccgca gacgatatcc caaacctttt tctgatggca gatgtatttg tgtgcagctc 2586241 tcagtggaac gaacccctcg cccgtgtgaa ttatgaagca atggcggccg gcacgccctt 2586301 aattaccaca aaccggggcg gaaacggtga agtcgtaaaa cacgaagtca ccggccttgt 2586361 catcgatagc tacaacaaac cttcttcatt tgcaaaagca attgacagag cctttacaga 2586421 tcaagaatta atgaacaaaa tgacaaaaaa cgcccgaaag catgtagaag ctttatttac 2586481 ctttacccat gctgccaaaa ggctcaatac tgtttaccaa tccgttctga ccccgaaaaa 2586541 caaacaattt ccgccgcctt ttctgacgca aaattttgat ttatcatcta tcaatcagct 2586601 ttttgtgaaa gcaaaaacat aaaacctaca gctcgtgttg caaaacgggc tgttttttcg 2586661 ctacagagaa cttaaaaaaa ggcataaatg tgactttatg ccttgcgctt tacagtttga 2586721 gaaaaccatg gagctggttt agattcactt ggaagaatga tgatttccac tttagcttct 2586781 tccgctaagt ctggttcttc atcttcatcc tcttcttcat atgggggcgc tgagcgtttc 2586841 gaatcacgct cctcctcagg ctccagagtg gtttcgaatt ttgtttcttc ttcatcatcg 2586901 acgattttgc gatctgtttc cttttccttc gtttcttttt gatattcttt cggtgcattg 2586961 atgtgaggga gctctcgaat gctgcccaca tctaaatgct tctcctcttc ttccttctca 2587021 gctgagattg agtcatgagc ctgccatccc atcggtccag gcggtgtaaa tacgaattgg 2587081 tcgagatcca gtttagaaat agaggctttt tgtctcgatg acctcatgtc aattcgcctc 2587141 ccgatacgct tttatctttt tatacagttc cggcagttta tccaaaaacg aatctttaga 2587201 ttcttcaaca gaaatcatgt tttgcagcgc ccagttatac ttctcatctg accacgtttt 2587261 cttttgcttc aaataatatt tgtgcccgat tgcacagaac aaatgcggaa acgcgagatc 2587321 aatccaaagt acctcgtact gtttttctgt gagcggatac actgcgtcgt aggccgcaag 2587381 cagtgcaacc atgaaatcag tatcccatac agaaagctta accatcactt tattcagcag 2587441 aatacgaagg tctcttgacg gcaaatcgta ggtaatcgag tgaagctcct ttaaaaaagg 2587501 ctccccttcg atctcagtca aacgtgccaa tgtaaaatcc tgaaaacaga atccgccatg 2587561 ctcgagtgtc tcttttgtcc aggtttcgta ttctgagtca tcaagcgctc tgagagcttc 2587621 ttttcctctt gccagcattt tatcagcatg ttttaagaaa gtttgcgaaa atacgtcatc 2587681 aggataggat gctgcgatct gcatattccc ttcaagttcc tgcagcttcc aacggtacaa 2587741 tttgtgccat tttcccagcc tgcttctctt cttgctttca tctgtgcaaa catatccttt 2587801 tgaggcatga tgaaaatggc cggcaaatga catgactttt ttcatttgct ctgcatcata 2587861 gtaaatcatt tcttttcctg tcactttgtc atataaactg taagaaacct gatccgtgcc 2587921 caagcagcta ccgccatttt ttgtttgatg aatcggcgct atcggcagcc ctttctcttg 2587981 taaatgggcg tgtgcctgag tgataaaaag catccgctcc ggtttcattt gcgcttcttt 2588041 tagcagcttt gggccatgat cagtttcgac ttcccagatt ttgcgcccgc ttttgttcga 2588101 tttcagcgcc acatggtcga tatgaaacgg ataataactg agaatttcgg acacaatctg 2588161 ttcttcatgc tctttttggt acactctgtt caccccttct atctgttctt ttcatagacg 2588221 ctgagcagat tttcagccac cctctgccag ccaaaattgc tttctgcctc acggcggctg 2588281 tatttcccaa gccgttcccg cttttccgag ctgctcagca aatcattgat acgttcggca 2588341 tattgtttag gattttcaaa gtcatgaatg atgtagccgt ttttcccttc ctctatgacc 2588401 tctggattgc ctccccgatt gcttgtaata ataggaagtc ccgcagccat cgcttcataa 2588461 tgcacccttg ctaaaggctc ctgccattgc gaagagcata caaatacatc tgacatggta 2588521 taaaggcgcg gaatgtcctt tggcttcaca aattgaataa atgtgacatg atccttttgc 2588581 atcgcaccaa gggtatgaag atgtttgaca tagttattta attcattatc tccgaaccat 2588641 tttgacccga taaacaccat catgacatcg gggtgctcct caatgatgtc cggcaaagcc 2588701 tgcaataata tgtgcgggcc tttgactttg ctaagccggc cgacaaacaa gacgattttt 2588761 ttgccgtgaa gccccagctc gcttcgcatc tcttcgcgag ctcgctgccc ttcattcgtc 2588821 cagcgagggt ggtacgtttt taaatccaca ccagaataca ccgtttttgt ttttgatcgt 2588881 gctgacggaa aacggcttgt gatcgtctgt ccgatataat cgctgaccgt aacaatctgc 2588941 gctacggagt cgatgcaaat ctcgccttcc gcctggctga ttttatcgta agcgaacatt 2589001 tcattgtgaa cgcttaaaat aaaaacagca tccggcgcct gtttcttcaa tttcggaacc 2589061 cagcttgggc gattacaaac atgcacaaga tcaaaacggc tctttttcag ctctgctcca 2589121 acggcttctt cataacggtc ttcatccaaa tgcacataat ggacaccgtc taccttctct 2589181 ctatcagcga gattcggatc tttaatagaa aacacagtca cctcatgttt ttttgcaatt 2589241 aaaggggcaa ccgcttcgag gtagatttga atggcgcctc ctcgaaccga tgggacagga 2589301 agcttctctg tggcgatcag tgctattttc atacatagcc tccattcctg catgattttt 2589361 aactagttag aatcatgata cggctgaaca accaacttgt gcggaatggg actgccctaa 2589421 aaacaaaacg ggtaaacaac cagattcatc tattaaatat agtcaaataa ctcaatcatt 2589481 ttttcctttt gattcataag gtaggagtaa aacaggtaag gatgtgtcct ttaatggcag 2589541 aaaaccatga agtcattgag gaggggaatt catcagagct tcctttatca gcagaagatg 2589601 caaaaaaatt aacggagctg gctgaaaatg tgcttcaagg atgggatgtg caggctgaaa 2589661 aaatagacgt cattcaggga aaccagatgg cgcttgtctg gaaggtccac acagactccg 2589721 gcgcggtttg tctaaaacga atacacaggc cagaaaagaa agcgttgttt tccattttcg 2589781 cgcaggacta tttagcaaaa aaaggcatga atgttcctgg catactccca aacaaaaaag 2589841 gcagcctata ttctaagcac ggctcatttc tatttgtcgt atatgactgg atcgaaggaa 2589901 gaccgtttga gctgactgta aagcaggact tggagtttat catgaaaggc cttgctgatt 2589961 ttcatacagc ttccgtcgga tatcagccgc caaatggcgt tcccatattt accaaattag 2590021 gtcgctggcc gaatcactac acgaaacgat gcaaacagat ggaaacgtgg aagctgatgg 2590081 cggaggcgga aaaagaagat cctttctcac agctttatct tcaggagata gatggcttta 2590141 ttgaagacgg gctgcgcatc aaagaccggc ttttgcaatc gacctatgtt ccatggactg 2590201 aacagctgaa aaaaagccct aacctttgcc accaggatta cggaaccggg aatacactct 2590261 taggagaaaa tgaacagatt tgggtcatcg acttagatac cgtatcattt gatctgccta 2590321 ttcgcgattt gcgcaaaatg attattccgc ttttggatac gacgggtgtt tgggatgacg 2590381 aaacatttaa tgtcatgctg aacgcatacg aatccagagc cccattaact gaagaacaaa 2590441 aacaagtcat gtttattgat atgctgtttc cttacgagct ttacgatgtc attcgcgaaa 2590501 aatacgtccg caagtctgct ttaccgaagg aagaattaga atcagctttt gaatatgaac 2590561 gcattaaagc aaacgcattg cggcagctta tttaagacca tcatttcccc cgcatatcgg 2590621 gggtttgata tttataagat aaagggtaat taaatacatg cggaggttgc aaatatgaaa 2590681 aagattgtcg gcgctttagc cgtttttgtg attacatatg cgctgttttc agccgcaggc 2590741 tacctgtttc ctgtggacca agaatggtac aattcattga aaaaaccgga ctggacgcca 2590801 agcggaactg cgatcggcat catttgggcc atcctgtttg ccctgatctc cctttcagca 2590861 gccattgtat atgctgcgtt ttcatttaaa ggtgcgaaaa gcttttggtt tacacttttg 2590921 ataaattacg tgctcaatca agccttcagc tatttccagt ttacgcaaaa aaatctgctg 2590981 gctgcatcgc ttgactgcct gcttgtcgcc atcacagcaa tcgtattact gatcattgcc 2591041 aaaaaataca gcagagccgc aagctatctt cttttgcctt attttttatg gagtgcattt 2591101 gcgacgttct tatcctttac aatcaattca atgaatctgt gaacaaaaaa agccgcttat 2591161 acagcggctt tttcacatca tcggcttgat gccccaaatg tccttcgcat attcccggat 2591221 cgtgcggtcg ctggagaaat atccagaatg agcaatgttt acaatcgaat gctcagacca 2591281 tttccttcgc tctcgataat cagcttgaat tcgctcctgt gcatctgcat atgagctgaa 2591341 atccttcagc acaaaatact catcattatg cggaagcagc gagtcaaaga tcgattcaaa 2591401 ttcatctgcc tctccttcaa aaaaaccatt gatcaactga tccgctacct gcctgattct 2591461 cctgtcatgc tgataatatt ccctcgacct atagccgccg ttttcctgat acgatagaac 2591521 ctcatccgcc tttaagccga acgtgtaaat acagtcaggg cccacccgct caaggatctc 2591581 gatatttgcg ccgtcatgcg tgccgatcgt caaagccccg ttcatcataa acttcatatt 2591641 ccctgtacca gacgcttcct tgcttgcggt tgaaatttgc tcacttacgt ctgatgccgg 2591701 aaaaattcgc tcagccatag aaactctata attttctaaa aaaacaactt tgatcagctg 2591761 tttgaccgcc ggatcataat tgactttttc tgcgacagaa tggatcagct taatgatttt 2591821 cttggcataa taatagcttg gtgaagcctt tgccccgaaa ataaaggttt gcgggtagat 2591881 tgaaaacccc gaatcctcct tgaggcggtt atacaaatac ataatgtgaa gaacattcag 2591941 cagctgccgt ttatatgcat gaagccgttt cacctgtacg tcgaatatgc tctcagggtt 2592001 cacaaccacc ccggccgtgc aaaaaatcaa atcggcaagc tcttgttttt tcttgctttt 2592061 gttgttttga aactgttcaa taaatgcagg atcagtggcg tacggttcta aacggatcag 2592121 tgattccggc tgcttgaccc attcatcgcc gatcgcctct gtaatgatgg cagacaagcc 2592181 tggattcgct tttaacagcc agcgcctgtg ggcaattcca ttcgtcttat tgttaaaacg 2592241 attcggaaac agcaagtgaa agtcgcgcat ctccctttcc tttaatatat cggaatgtat 2592301 ttttgcaacg ccatttacac tgtagctgcc tactatggcc agatgagcca ttttgacaac 2592361 accatgcgct gtaatcgcca tgttctctat ccttttccag tctccaggat acttttccca 2592421 aactgcacgg caaaacctct cattgatctc ttcaataatc atgtacattc gcgggagcag 2592481 cggcttaaac aaatgaatcg gccatttctc gagcgcttct gacaatgttg tatgatttgt 2592541 ataagaaatc gtatgtacag tgatatgcca agcttcttcc cagctcatgt tctcttcatc 2592601 gagcaaaatc cgcattagct caggcaccgc aagcgcaggg tgagtgtcat taatatgaat 2592661 gctcactttt ttatgcaggc cggataaaga tttatgtgtt ttacggtaat tgttcacaat 2592721 gctttttaag cttgcgcata ctaaaaaata ctgctgcttc agccgtaaaa ttttcccctc 2592781 atcatgggtg tcatcgggat ataagaattc agaaaccgct tctgtttctc gcttataaga 2592841 caaaatatta ccgccgtgat aatgggcata gggctcggcg ttccaaagcc ttaacgtgtt 2592901 gacagtgccc gtttcatagc cgatgatcgg gatatcataa ggaacagcgg taacaattgt 2592961 cgcttgttca tggcgaaaat gcaggcgccc gcttttttct gtcatatgga cttcgcccca 2593021 aaacggcacg tccactgctt gatccgcatt ccttacttcc catacgttcc cgtttttcag 2593081 ccattgctca ggcagctcca cctgatgtcc gtctacaatt ttttgctcaa acaaaccatg 2593141 cttataacgt atgcccatgc cgtgcccagg caggttcaac gaagcaagcg aatctaaaaa 2593201 gcaagcggcc aagcgcccaa gtccgccatt gccgagacct gcatcgttct ctatctgaag 2593261 gatctcctct aaattgatgc cgatttcctt taaaccagct tctacaacat cacgaacacc 2593321 aagattcatt aagttttgct caaggagctg accgagcaga aattcgattg ataaataata 2593381 tgtctgcttc ccggaatttg atctgctttt ttcattcgtt tcgatccaat cagcgctgat 2593441 atactctctg accatattgc ccaacgtttt atattgatcc agcttggcag aatctttaaa 2593501 gctttttccg cacgtcattt ccagacgctt taaaaataag tctgcaaagc gttctttact 2593561 cgagaacatc ccgtccactc cttgtcacct gctcgaaaat acgctgatac tctttagccg 2593621 acttccccca gctgtaatct gcattcatag cggtcttcac gatgctcttc catacatcct 2593681 gttggcaata aaacgacagc gccctttcta tcgtaaattt cagatcatgc gcattaaagg 2593741 cggaaaacgt aaagccattg cccgttccct cttcctcctg ataggcacgg acagtgtcgt 2593801 aaagaccgcc cgtttccctg acaatcggaa tggcgccata ttgaagagca atgagctgcc 2593861 ccaaaccgca cggctcaaat ttcgacggca tcaaaaacat atcagagccc gcataaattt 2593921 gatgggctag cggctcatca aacccgatat aagcccggca cttctcatga aaagcaaatt 2593981 ctgcataccg gaaataatct tcaaattcac gttctcctgt gcctagcaca accagctgta 2594041 tgtcttgctc ctcaagaagt tcgtgcataa ttctgcggac aagatcaagc cccttttgtt 2594101 tagtgagcct tgtcaccata ctgatcagcg gaatatcgtt tttctctgga agccccatcc 2594161 gctgctgaag cttcgttttg ttttccagct tgcatgcaag atcccctgaa tcgtattgcg 2594221 cctctatata agggtcgctt ttcggctgat agaacgtatc atcaatgcca tttaatatgc 2594281 cggttacatc atcttcccta tattgcaaaa cctgttccaa ctgctcacca taatacggcg 2594341 tcatgatttc atttctgtaa gtggggctca cagttgtcac atgatcagcc gcaatgatgc 2594401 ccgctttcat aaaattaaca aatccgttgc attctaacct ttcataatga aaatgatcca 2594461 tctcaagacc cagcaagtca tgtgtgacat caggagggaa tatgccttga aactgcaggt 2594521 tgtggatcgt gagcacgctt ttcatccgtt cataaaaagg atgttttctg tactcctctt 2594581 tcagcaaata attgaccatc gctgtatgcc aatcgtgagt atgaacaata tcggcttgaa 2594641 cattcacaac tttggcagcc tccagcacag ctcttgaaaa aaaggcaaac cgctcaccgt 2594701 catcataatg cccgtacaac gaatccctgt tgaaatagta ctcattgtcg atgaagtaat 2594761 aattcacatc attctctgcc atatgttcaa ttccgcaata ttgctgccgc cagccgacag 2594821 ctacggtaca ctcagcctgt tttttcatac gctttttcca cggttcaggt atttggctgt 2594881 acttcggcag catcacagct acctcattgc ctaatcgcgc aagcgccttt ggcagagcac 2594941 ctgctacatc ggcaagacct cctgatttca caaatggggt gcattctgac acagcaaata 2595001 atatcttcaa gaattcatca gctctccttg caccaaacct tttcttaata caagcggctg 2595061 ctcagctgtt cctgcagctt ccgtcgcctt gccgatttta acatccttat ccgaaatgac 2595121 ctgctcaaga agacaatcct ctccaatctg cgttttttgc ataataatgc agtttttcag 2595181 cttcgtaccc tttccgacat ggaccgccct gaacaaaatg cagttttcaa cctctccttc 2595241 aagcacacag ccgtttgcca ccaaagaatt tttgacagtg ctgtgctttc cgtatttcgt 2595301 aggcggctca tccttcactt ttgtatagat cggctgctgc ggcaaaaaca cctgctgcca 2595361 aaaacgaggc tgaatgagct ccatactgtg ggtataatat ttttccaccg aatcaatgac 2595421 agcggcataa cctgaatatt cataagggca aatggtcagg gcggaagatt ccttttcaac 2595481 agcctcctga atggttttat agcctttttc gctatgtccg tagatcagat cctttaaaag 2595541 cgttgttgac atgatataga tttgcagcga ctggccgtcc tgaaatacct cggtgacgtc 2595601 gcagccaacc tcctgatggc gtttcagcac atattgaaat tgaatgttgc atacggtatg 2595661 gctgttggag attacagcat attgctgagt gcttctgtgg aagtaatcta gatggtccga 2595721 aaactggcga aaggaaccga attcatcgta ttcgtgatga agatggggag acgggaaaaa 2595781 aaagaggccg tcctttttcc ggtgcaaatc ccattcctta cccgccccaa ggtgatccat 2595841 gagcgaacgg taacgatact tcggaaaaat tgcaacactc ctaatatccg cattcaccat 2595901 gttggaaagc ataaaatcaa tcagtcggta cctgccggca aaagggatcg ccccgagcga 2595961 ccgctgtgct gttaaatcct gaagagaatg cttatatgtg gtttcatcta taacacctaa 2596021 catttgatta ttgaacactg actctgcccc ctcttcagta attaaatcaa ttctttttct 2596081 acaaattcct ctgaaacgag cagcacctct tcaatgtctt tttcggagcg aatcactgcg 2596141 ccatccggca gcaccatccc attaggaacg atggcatttt caatgactac atgctcccca 2596201 atcgtcacat ccggcattat gacggatgat gtaacagtcg tatgcttacc aacagtcaca 2596261 ccttgaaaaa gaacggagtg agacacattt ccatatacaa cacaaccttc gttcacaagc 2596321 gaatcttgaa cctgcgcatc agatgaaata aattgcggag gctgatttgg attgacggag 2596381 taaattttcc atttgcgttc aaacagcttc agctccgagt cctcttttaa caaatccata 2596441 ttggcttccc acaagctctg caccgttccg acatccttcc aatatccctt gaacggataa 2596501 gcagaaagct tctttttctc ttccaaaagc agtggaataa tgtctttgcc gaagtcgtgg 2596561 ctagaataag ggttttgatc gtccatctca agatactgtt tcaaaagcgg ccaattgaat 2596621 atataaattc ccattgaggc aagattgctc ttagggaatt tgggcttttc atcaaaatgt 2596681 gtgatcgtcc catctggatt ggccttcatg atgccgaacc ggcttgcttc ctcccagccc 2596741 acttcgatga cagagatggt cacatctgct ttcttttcaa tgtgataatc aagcattttg 2596801 ccgtagtcca ttttgtatat gtgatctcct gataaaatca gtacatactc aggatcatac 2596861 tgattcaaat aattgagatt ttcataaatg gagcttgccg tccctttata ccatttgact 2596921 tctgatgact cggcataagg gggtaaaacc gtcacgccgc cattatatct atccaggtcc 2596981 catgcactgc cgatcccaat ataggaattc agctcgagcg gctgatattg cgttaaaatc 2597041 ccgactgtgt ctatgcctga attagaacag ttgcttaggg taaaatcaat aatcctgtat 2597101 tttcccccga aagatacagc cggtttggcc atattttttg ttaatccgct gagacggctg 2597161 cccttcccgc cggcaaggag catggctaca cattgttttt tcatcttttt atctctcctc 2597221 tttttttaac cgcccgtaaa atcgagatgc cgtaaggggg gatggtcatc gtgatataac 2597281 acggtttatg atgaagtgct ccctttttag ccgataacgg ctttttgttg atttgccctg 2597341 agcctccata tgtttcactg tcactgttaa gcacttcaat gtattgagta aaaaaaggaa 2597401 ctccaacatc atattgatga tagaccacgg gtgtaaaatt acaaatgatg acaagcgcct 2597461 caccgtgctt ttggccataa cgaataaaag aaaagattga ttgttcgtca ttatggacat 2597521 caatccattc aaacgattgt gcacgatggt catgctcata aaggattttg cttttttggt 2597581 aaaagcggag aagatcttgc gtaaaaacgc tggctttctg atgcatgggg aaggagtcca 2597641 aaaaccaatc aagctgttct gtatctttcc attcatcaaa ttgagcaaac tctgatccca 2597701 taaagatcaa tttctttccg ggatgcactg tcatatagcc cagcaaaagc cgatactggg 2597761 caaatttctg ccagtagtcg ccaggcattt tattgagaag tgattttttt ccgtatacga 2597821 cttcatcatg agaaaacggc aatacaaaat gttcactaaa cgcatatagt aatgaaaaag 2597881 agataagctg atgacaatgc cgcctttctt cgggcggcgt ctccatgtat ttcagtacgt 2597941 cattcatcca tcccatattc catttataat gaaaaccaag ccccccttcc tcaacggcac 2598001 ctgtcacttg aggccattct gtagaatctt ctgcaatcat catcacatgg ggatatgcct 2598061 ctctcatggt ttgattgagt ttttttaaaa aatcaacagc atatggattc gtgtggcgtt 2598121 catcctgatt tggccaatac aagatattag ccactgcatc aaccctaaat ccatctatat 2598181 gatagaattc cgcccagtac aacgcattcg aaattaaaaa actatgaact tccggtttcc 2598241 ccaggtcaaa gtttgccgtg ccccataacc agttctcccg atcacgttct tctttgtatt 2598301 cataaagcgg ttctccatca aacatataaa ggccatgtgc atctttacaa aaatgtccgg 2598361 ggacccaatc caaaatgact ccgatatttt gttgatgaca ttcatccaca aacttcatca 2598421 gatcatgcgg cgggccaaac ctgcttgtcg ggctgtaata ccccgttcct tggtaccccc 2598481 atgaacgatc atatggatgc tcatacacgg gaagcagttc aatatgggta aacccatgct 2598541 tcttgatata agggataagc gtctgactta attctttata ggaataatgc ctgccatcag 2598601 aatgcttctt ccaagaccca agatgcagtt cataaatgaa aacaggtttt tcatacagcg 2598661 tcttagcctt ctgtttcttt tgccattttt gatcttgcca gctgtatcct tccaaatcgt 2598721 aagtaagtga cgctgtgttt ggtctgactt ctgaataaat agcgtatgga tctgccttca 2598781 gcctgatctc accgttattc gtcacaattt cgtatttata tcgttccttt tctcctatac 2598841 ctggaataaa taacgtccaa atgccattat cattcactct gtgcatcaca tgctcttctc 2598901 cagaccagct gttaaaatct ccagccactc gtacttccga cgcatgaggc gcccacacac 2598961 agaattcata tccgcttttg ccattcagct cgcggtaatg cgagccaaac agctgatagc 2599021 ttttaaacag actgccttcg tgaaaaagat aaacatcatg tgctgtcggg ctggcagcgg 2599081 ccatgtaatc atcctttctg acatcatagt tttcatttat agtatttatt cgaagaaata 2599141 aaaaaaagcc ctttcctgaa agcgcttata cttatagaca attaacttca ttttctgaag 2599201 aaaaacgaaa tatatggaga tttttgtagt ctgtttttaa aataaagaac aaaatctaag 2599261 acatatcatg atttataaaa acaaaaaaac cttgcaggat atgcaaggct tctggatgac 2599321 ccgtacggga ttcgaacccg tgttaccgcc gtgaaagggc ggtgtcttaa ccgcttgacc 2599381 aacgggccga taattatgat atctgtaatc atatggcgga gaaggaggga tttgaaccct 2599441 cgcgccgctt acacgaccta cacccttagc aggggcgcct cttcagccac ttgagtactt 2599501 ctccatttgg ctccacaggc aggattcgaa cctgcgaccg atcggttaac agccgatagc 2599561 tctaccactg agctactgtg gaacaaaagt catggtgggc ctgaatggac tcgaaccatc 2599621 gacctcacgc ttatcaggcg tgcgctctaa ccagctgagc tacaggccca tgacgatata 2599681 gaaatggagc gggtgatggg aatcgaaccc acgacatcag cttggaaggc tgaggtttta 2599741 ccactaaact acacccgcaa tttttatttg gggcgattga tgggaatcga acccacgaat 2599801 gccagagcca caatctggtg cgttaaccac ttcgccacaa ccgccaaagc atattgataa 2599861 atggtggctc gggacggaat cgaaccgccg acacacggat tttcagtccg ttgctctacc 2599921 aactgagcta ccgagcctaa gtatttaaat ggcggtccgg acgggactcg aacccgcgac 2599981 ctcctgcgtg acaggcaggc attctaacca actgaactac cggaccattt taaaatttgg 2600041 ttgcgggggc aggatttgaa cctgcgacct tcgggttatg agcccgacga gctaccgaac 2600101 tgctccaccc cgcgatgatt aggaatatgt atggcggagg aagagggatt cgaacccccg 2600161 cgggctttga cacccctgtc ggttttcaag accgatccct tcagccagac ttgggtattc 2600221 ctccgtatag tggtggacct tgtaggactc gaacctacga ccggacggtt atgagccgtc 2600281 tgctctaacc aactgagcta aaggtccatt ggtagcggcg gaggggatcg aacccccgac 2600341 ctcacgggta tgaaccgtac gctctagcca gctgagctac accgccaaat atttttgaaa 2600401 tcaagtggag cctagcggga tcgaaccgct gacctcctgc gtgcaaagca ggcgctctcc 2600461 cagctgagct aaggccccaa gaatggtcgg gaagacagga ttcgaacctg cgaccccatg 2600521 gtcccaaacc atgtgctcta ccaagctgag ctacttcccg atttcatata gatcatggcg 2600581 cgcccgagag gagtcgaacc cctaaccttt tgatccgtag tcaaacgctc tatccaattg 2600641 agctacgggc gcaaaactta atgccgaggg ccggacttga accggcacgg tagtcaccta 2600701 ccgcaggatt ttaagtcctg tgtgtctgcc aattccacca ccccggcgtg gatggtatag 2600761 ttggagcgga agacgggatt cgaacccgcg acccccacct tggcaaggtg gtgttctacc 2600821 actgaactac ttccgcagaa atggtgcgga tgaagggact tgaaccccca cgtctgtaaa 2600881 gacactagag cctgattcta gcgcgtctgc caattccgcc acatccgcaa catgtaaatg 2600941 gtgagccatg aaggactcga accttcgacc ctctgattaa aagtcagatg ctctaccaac 2601001 tgagctaatg gctcttctta caatagactt gaatattata tcatataaaa gtggtgccgg 2601061 caagaggact tgaaccccca acctactgat tacaagtcag ttgctctacc aattgagcta 2601121 caccggcata tatgtaaaac cgatatgtat aatgaaaaat ggtggaggat gacgggctcg 2601181 aaccgccgac cctctgcttg taaggcagat gctctcccag ctgagctaat cctccatact 2601241 tgcactaacg tgcaattgct tggcggcgtc ctactctcac agggggaaac ccccgactac 2601301 catcggcgct gaagagctta acttccgtgt tcggtatggg aacgggtgtg acctcttcgc 2601361 tatcgccacc aaacaaattg agagtgttct ctcaaaacta gataacaggt gtgacatcat 2601421 tcaaaaatat ggttaagtcc tcgatcgatt agtatctgtc agctccatgt gttgccacac 2601481 ttccacctca gacctatcaa cctgatcatc tttcagggat cttacttcct tgcggaatgg 2601541 gaaatctcat cttgaggggg gcttcatgct tagatgcttt cagcacttat cccgtccgca 2601601 catagctacc cagcgatgcc cttggcagaa caactggtac accagcggtg cgtccatccc 2601661 ggtcctctcg tactaaggac agctcctctc aaatttcctg cgcccgcgac ggatagggac 2601721 cgaactgtct cacgacgttc tgaacccagc tcgcgtaccg ctttaatggg cgaacagccc 2601781 aacccttggg accgactaca gccccaggat gcgatgagcc gacatcgagg tgccaaacct 2601841 ccccgtcgat gtggactctt gggggagata agcctgttat ccccggggta gcttttatcc 2601901 gttgagcgat ggcccttcca tgcggaacca ccggatcact aagcccgact ttcgtccctg 2601961 ctcgacttgt aggtctcgca gtcaagctcc cttgtgcctt tacactctgc gaatgatttc 2602021 caaccattct gagggaacct ttgggcgcct ccgttacctt ttaggaggcg accgccccag 2602081 tcaaactgcc cacctgacac tgtctccccg cccgataagg gcggcgggtt agaaggtcaa 2602141 tacagccagg gtagtatccc accgatgcct ccaccgaagc tggcgctccg gtttccaagg 2602201 ctcctaccta tcctgtacaa gctgtaccaa cattcaatat caggctgcag taaagctcca 2602261 cggggtcttt ccgtcctgtc gcgggtaacc tgcatcttca caggtactat aatttcaccg 2602321 agtctctcgt tgagacagtg cccagatcgt tgcgcctttc gtgcgggtcg gaacttaccc 2602381 gacaaggaat ttcgctacct taggaccgtt atagttacgg ccgccgttta ctggggcttc 2602441 aattcgcacc ttcgcttacg ctaagcgctc ctcttaacct tccagcaccg ggcaggcgtc 2602501 agcccctata cttcgcctta cggcttcgca gagacctgtg tttttgctaa acagtcgcct 2602561 gggcctattc actgcggctc tctcgggctt gcaccctaac agagcacccc ttctcccgaa 2602621 gttacggggt cattttgccg agttccttaa cgagagttct ctcgatcacc ttaggattct 2602681 ctcctcgcct acctgtgtcg gtttgcggta cgggcacctc tcacctcgct agaggctttt 2602741 cttggcagtg tggaatcagg aacttcgcta ctatatttcg ctcgccatca cagctcagcc 2602801 ttatgggaaa cggatttgcc tatttcccag cctaactgct tggacgcgga tatccaatac 2602861 cgcgcttacc ctatcctcct gcgtcccccc attgctcaaa tggtgaggag gtggtacagg 2602921 aatatcaacc tgttgtccat cgcctacgcc tttcggcctc ggcttaggtc ccgactaacc 2602981 ctgagcggac gagccttcct caggaaacct taggcattcg gtggagggga ttctcacccc 2603041 tctttcgcta ctcataccgg cattctcact tctaagcgct ccaccagtcc ttccggtctg 2603101 gcttcacagc ccttagaacg ctctcctacc actgttcgaa gaacagtccg cagcttcggt 2603161 gatacgttta gccccggtac attttcggcg cagagtcact cgaccagtga gctattacgc 2603221 actctttaaa tggtggctgc ttctaagcca acatcctggt tgtctaagca actccacatc 2603281 cttttccact taacgtatac tttgggacct tagctggcgg tctgggctgt ttccctttcg 2603341 actacggatc ttatcactcg cagtctgact cccaaggata agtcattggc attcggagtt 2603401 tgactgaatt cggtaacccg gtaggggccc ctagtccaat cagtgctcta cctccaagac 2603461 tcttaccttg aggctagccc taaagctatt tcggagagaa ccagctatct ccaggttcga 2603521 ttggcatttc acccctaccc acacctcatc cccgcacttt tcaacgtgcg tgggttcggg 2603581 cctccattca gtgttacctg aacttcaccc tggacatggg tagatcacct ggtttcgggt 2603641 ctacgaccac gtactcatgc gccctattca gactcgcttt cgctgcggct ccgcatcttc 2603701 tgcttaacct tgcacgggat cgtaactcgc cggttcattc tacaaaaggc acgccatcac 2603761 ccgttaacgg gctctgacta cttgtaggca cacggtttca ggatctcttt cactcccctt 2603821 ccggggtgct tttcaccttt ccctcacggt actggttcac tatcggtcac tagggagtat 2603881 ttagccttgg gagatggtcc tcccggattc cgacggaatt tcacgtgttc cgccgtactc 2603941 aggatccact caggagagaa cgaagttttg actacagggc tgttacctcc tatggcgggc 2604001 ctttccagac ctcttcatct acctcgttct tttgtaactc cgtacagagt gtcctacaac 2604061 cccaagaggc aagcctcttg gtttgggctg atcccgtttc gctcgccgct actcagggaa 2604121 tcgcatttgc tttctcttcc tccgggtact tagatgtttc agttccccgg gtctgccttc 2604181 tcatatccta tgaattcaga tatggatacc actccattac gagtggtggg tttccccatt 2604241 cggaaatctc cggatcaaag cttgcttaca gctccccgaa gcatatcggt gttcgtcccg 2604301 tccttcatcg gctcctagtg ccaaggcatc caccgtgcgc cctttctaac ttaaccgtta 2604361 aaaagaatca ctatgtgata tcttgtgtta ctaattgaat gtgatgtcta ctgttatcta 2604421 gttttcaaag aacacgtttc gaaggaatga tccttcaaaa ctaaacaaga cagggaacgt 2604481 tctgtttata agaccttggg tcttatattc cgtataatat ccttagaaag gaggtgatcc 2604541 agccgcacct tccgatacgg ctaccttgtt acgacttcac cccaatcatc tgtcccacct 2604601 tcggcggctg gctcctaaaa ggttacctca ccgacttcgg gtgttacaaa ctctcgtggt 2604661 gtgacgggcg gtgtgtacaa ggcccgggaa cgtattcacc gcggcatgct gatccgcgat 2604721 tactagcgat tccagcttca cgcagtcgag ttgcagactg cgatccgaac tgagaacaga 2604781 tttgtgggat tggcttaacc tcgcggtttc gctgcccttt gttctgtcca ttgtagcacg 2604841 tgtgtagccc aggtcataag gggcatgatg atttgacgtc atccccacct tcctccggtt 2604901 tgtcaccggc agtcacctta gagtgcccaa ctgaatgctg gcaactaaga tcaagggttg 2604961 cgctcgttgc gggacttaac ccaacatctc acgacacgag ctgacgacaa ccatgcacca 2605021 cctgtcactc tgcccccgaa ggggacgtcc tatctctagg attgtcagag gatgtcaaga 2605081 cctggtaagg ttcttcgcgt tgcttcgaat taaaccacat gctccaccgc ttgtgcgggc 2605141 ccccgtcaat tcctttgagt ttcagtcttg cgaccgtact ccccaggcgg agtgcttaat 2605201 gcgttagctg cagcactaag gggcggaaac cccctaacac ttagcactca tcgtttacgg 2605261 cgtggactac cagggtatct aatcctgttc gctccccacg ctttcgctcc tcagcgtcag 2605321 ttacagacca gagagtcgcc ttcgccactg gtgttcctcc acatctctac gcatttcacc 2605381 gctacacgtg gaattccact ctcctcttct gcactcaagt tccccagttt ccaatgaccc 2605441 tccccggttg agccgggggc tttcacatca gacttaagaa accgcctgcg agccctttac 2605501 gcccaataat tccggaaaac gcttgccacc tacgtattac cgcggctgct ggcacgtagt 2605561 tagccgtggc tttctggtta ggtaccgtca aggtaccgcc ctgttcgaac ggtacttgtt 2605621 cttccctaac aacagagctt tacgatccga aaaccttcat cactcacgcg gcgttgctcc 2605681 gtcagacttt cgtccattgc ggaagattcc ctactgctgc ctcccgtagg agtctgggcc 2605741 gtgtctcagt cccagtgtgg ccgatcaccc tctcaggtcg gctacgcatc gttgccttgg 2605801 tgagccgtta cctcaccaac tagctaatgc gccgcgggtc catctgtaag tggtagccga 2605861 agccaccttt tatgtttgaa ccatgcggtt caaacaacca tccggtatta gccccggttt 2605921 cccggagtta tcccagtctt acaggcaggt tacccacgtg ttactcaccc gtccgccgct 2605981 aacatcaggg agcaagctcc cacctgtccg ctcgacttgc atgtattagg cacgccgcca 2606041 gcgttcgtcc tgagccagga tcaaactctc cgataaatgg atcacaggtt aagttcaccg 2606101 catcctgcgg cgacacctgt gtgacctgcg tcgtgcaggc cctagtttga ctgactacgc 2606161 acatcgcagt gcgattttta aaaactgaat taacaggtac gttttgtctt gtttagtttt 2606221 caaagatcat ttcgttactt ctcaatgaag cagctttact aatataacat tcagcttctt 2606281 ttttgtcaac aacttttttc aagttgtttt gaagcatcta gtttgtgtcc gctgtgcatc 2606341 agcgacgttt aataatataa cacctgtatt tatttattgc aatagttttt taaaaaaaat 2606401 ctataaaaca aataaactat aatcctcgcc atgatttcta aagcgtgtgt atcatataag 2606461 tttcttaaaa gaacatatac atcagtcatg tgatcttgtt gtttttttcg ttttcttgta 2606521 tagtagaaac gaactaaata ctgatgacca caaggggagc attaaagctg agagtgagcg 2606581 gtttcgttct gaccctttga acctgttagt taacgctggc gtagggatgt ggcaaagtca 2606641 aatgaattgc agatcgtaaa gcagtgcgtg gaacttttct catccttccg cgtgctgctt 2606701 ttttgttgtc cttttggttg tctgtcaatg gaaggagata gatatgaatc aatctaagca 2606761 actggttcgc cttattgaaa ttgccattat gacagcggca gccgttattt tagacattgt 2606821 ctcaggaatg tttcttagca tgcctcaagg aggctcggtc tccatcatga tgattccgat 2606881 ctttttaatt tcgtttcgct ggggtgtcaa agcaggtctt actacaggtt tgttgacagg 2606941 tctagtacaa atagcaatcg gaaacttgtt tgctcaacat cctgtacagc tattgttaga 2607001 ttacattgtc gctttcgcag caatcggcat aagcggctgt ttcgcttctt ctgtccgtaa 2607061 agccgctgta tcaaaaacaa aagggaaatt gattgtttca gtggtcagcg cagtttttat 2607121 cggcagtttg ctgcgctatg ccgcgcatgt catttcagga gctgtgtttt tcggcagctt 2607181 tgctccaaaa ggaacaccgg tatggattta ttctttaact tataatgcga cttacatggt 2607241 tccttcattc attatttgtg caattgtcct atgtttatta tttatgacag caccccgtct 2607301 gcttaaaagt gacaaagcgt aaaagtaaca atcccccagc gaattccgct gggggatttt 2607361 tcgttatctg ttaagaagtg tttttaaagc tgaaagatcc ggccagccaa gacctacttc 2607421 tttcagcctt actccggcaa tttcaaagtt gtcctccgct actctttcag gtgaataggc 2607481 ctgataaaat ataatcgagg gattctgctc aataacccaa acaaacatac ttgaaaaacc 2607541 atgttgaagc aaaaactccg ctccttttgc taagagcgcc ctgcctgcac cttgccgctg 2607601 gcgctcttcc agaagataaa tagcgtataa ctcgccgtca tagccttctt gttcagagcg 2607661 aataggtcca aatgaagcaa agccgaatac tgaacccttt tcgtcctgag caacaaatac 2607721 tccctttaac gagcgacttt tccatttgtc ttcaaattcc ttatagttca ggctgtttaa 2607781 ataatcaatc gggataattt cgtggtatgt tgtcctccag ctgtctacat gcacttttgc 2607841 aatgtccttt atatcctcta acttcgcttc acgtacagtt accatacggt tctgcccttt 2607901 ccttactctg atttttggat cgttttggct tctttgattt catttgttaa ttcattaatg 2607961 ctttgtttta cgtttccttt tcctgaaaag ttctcaagca tttcttttac atcaattcct 2608021 gaggatgctt ttaaactttc ttgcagactt gacattaagt tcgtcgcata gctggttact 2608081 ttgtttgctc cgcttgattc accgcttcct cctgtatcga caacggtgat tttatcaata 2608141 tttgaaagag gtgccgctgc ttgtttcgcg tattccggaa gcattttgac aatcatatcg 2608201 aaaatcgccg cctgcccgta ctgttcaaag gcggccgcaa ttttctcttt tgcttccgct 2608261 tctgcaagac ctttcaggcg gataacctct gcttctgtct ctcctttcgc tttttccgct 2608321 tctgcttttg ctagcccgtc aattcttact ttttccgcct cagcctttgc cattgcttca 2608381 atactgtact tcttggcatc ggcttccgcg agctgtttgg ctttctcagc tgctgcggac 2608441 tgctcaacag aataacggtc tgcatcggct tttttcttta cctctgagtc gtattgacgt 2608501 tcacggcgaa gaatttcttt ttcttctagt tctatttgtt tttggcgttc gataatttta 2608561 acctgcattt cctgctctgt gacttgctgg cgcgctcggg cagtctctaa atcatatgct 2608621 tggtcggcat tcgcttttgc cgtatcttgt tctctgcgga attcagccat tttgagctga 2608681 ttgatttttt cagcttcagc gatttccgtc gcccgttcaa gttctgattt ttttgcgtct 2608741 ttatcggctt ctgcccgctt aattcgggtt tctttatcag cctctgctgt tgcgatatca 2608801 gcatcgcgtt ttacttgggc aattctcggt ttccctaatg attcaagata accgttttta 2608861 tcacgaacat ctttaatggt aaacgagacg attacaagtc ccattttcgc gagatcctgt 2608921 gaagcgacac gctgcacctc ttgagagaat ttttctctgt ttttatagat ttcttctact 2608981 gtcattgagc cgagaatgga acgaaggtgg ccttctaaaa cctcccgcgc ttcctgctca 2609041 cggtcgtctt ttgatttccc taaaaattgt tcggccgctg tagcgatttc tcctatagaa 2609101 ccgccgattt taataatcgc agttccatcg gccattactg gcactccttg ttctgtatag 2609161 acttcaggtg tcgaaacatc gagtttgctt gataataggc ttagcggctc tgcctgctgg 2609221 aagacgggaa ggacaaaggt tcctccgccg cggacgattt taatacggtt gccgccttca 2609281 tcgacatgaa catttttatt acccagatag ctccctgtta caattaacgc ttcatcaggc 2609341 cctgctgtac gatacttcgt aataaacaca gctattagtg caattaataa aaagaataca 2609401 actccgatga tcattataat cggcattgtc atatcaaatt cctcctttta tgttaaatgg 2609461 gttcatgcgg agtaaccgaa agaactccgt tgttaatatc tacgactaac accgttgtcc 2609521 cgtaactgat ctgctgatta tcaaaactga ccgctgactt tgaaatggtc ccgcctatcc 2609581 cttctatgac cacttcacca aacccgtcaa ccggcacagc tgtaatcact ttaccgagtc 2609641 ttcctctgag atcatcttct ctatatgcca atgattcttc tgcagatgat aatggcacca 2609701 gtacaaagat gtgaagcaat accaccagca tgatcgaaag gatgcaagat aaaagcgcaa 2609761 tcagcaagct tgacagaggc aatacaagtt cacctatata tccgcccgct gaaaaacatg 2609821 taaaaaatga gagcactaat gtcggattaa gaaacggaat gccttctgac agccctgaaa 2609881 atacatctcc gaaaaacagg aataacagcg taaggctgcc cgcaataata agcgtataaa 2609941 gatacattgt ttgtataggt actccaaata actccaactt cctcatcctt tcttcatcaa 2610001 tgcattgatg aacggctgcc gttaccattt atacgagaca cctcgggaaa agtttcaaaa 2610061 ttttaagaca aataacccat ttgaagtgct ttataaatga taattgctta tatatatggt 2610121 aatgtcattt taggaggaga tatgatgagt atctttaatg aagccagatt agaaacgtgg 2610181 aacgaattga aaggactttc tgacgaaaag ctgaatcaaa agccttctgc tgaagaatgg 2610241 agcatacggg aagttcttga ccatttgaaa aaaatcgata tgaccgcaca aaaaatgttg 2610301 aaggaacgtg taaaggacgc tccgattaaa gaaattgaag aaaaaccgct tgaagtagca 2610361 caggacagaa ataataaacg gaaagccccg agtcatcttg agcctgcgca tgattttatt 2610421 tcaggcagcc aaatgaaacg tgagcttgat gtggtaagag agcagctgac tgctgcgatt 2610481 gcctctctga aagaagaaga ttttgaaaga gtgcttccgc atcctgtgtt tcaagagctg 2610541 actgtcagac agtggatcga ttttatcggc catcatgaaa aacggcacct cagccaaatg 2610601 aaagaaatta aagaaaagat agaaagggcc tgatttaatc agaccctttc tgcttttcgt 2610661 ttgacttttc gctgatagga atgaacttct atttcatcac ctgtgtaaac agcaccaggt 2610721 ctctccacaa tacagacaat ccctctaatg cccagtgcgt ggcggacgaa agccgacgcc 2610781 agcttcggtt ggtccggata ataagactga atgacttctc ccggctggat acacggatca 2610841 ttttcgccct cacacagcag agccgctccg ctcggaaaaa taatccggct tccttctttt 2610901 aatgaagtaa gatctggcat accgctgact gccacattcg ccccgagcca ttccggcaaa 2610961 attctcggca ctcccatttt taaagcgatt tcgttgcatt cctctattga aacaattgaa 2611021 atttgtctgc ggttgaaaat ttcagtccct cttgaaaaca ttggttctct ggctcccgct 2611081 tttttggtca ggccaaaatg caagtcgccg gggatgccgc cataatcaaa atcaagcttg 2611141 tccatttgct ttgttacgaa gctttttgta tctgcgatat ataagccttc cgcttttgca 2611201 gtcatacgct tccacatcag ctggcacctt ccttcttatc taaaatttcc acctatgctt 2611261 cattatccca aaaaatcccg ctctgtaaag gagcgggatt ttgattatac cgttttaggc 2611321 gtaaggttaa agcagcgttt gtagatccag ttgtatgctt tttcatttaa atctctaggg 2611381 tttccgaagg tttgcggatc tttcattgct tctttagaca agcgttcgat catatcaggt 2611441 gatactccct gctcttctaa agtcggcact tctaaatctt cgaccagatc atacatccaa 2611501 ttgacagatg ctttcgcagc ttcttctgtt gtcatcttgc ttgtatcaat accgaacgct 2611561 ttcgcaatac gcgcaaactt ctcaggatag cccttccagt tgtattccat gacagggccc 2611621 atcatcgccg ctacacattg gccgtgagcg actgggataa taccgccaag cgtttggctc 2611681 atcgcatgag cagcgcccgc tgattcactt ccgtaagaaa gaccggcaag catcgcagcc 2611741 tgcgccattc cgtaccttgc ttccagatcc tctccatcag caaatgccct cttgatgtaa 2611801 tgagcggcat actcaatcgc cattaaggca accgcatccg tgattggctg tgcaaatttc 2611861 attgtatagc actcaatggc atgggcgagc gcatcaattc ccgtcatagc tgttacatgc 2611921 ggaggcattg aaacatgaag ctcaggatca atgattgtca agtgcgctgc aatcagcgga 2611981 ccgcccgtgt tgaatttgaa ttctctttct tcatctgtga taaccgccca ttgggttact 2612041 tctgatccgg ttccagctgt agtgggaatt gtcgtcagcg gaggaatgcg gttttccagc 2612101 ggttttttcc catctgccgc ttcataatca agcacgcttc cttcgtgagt cgcttctact 2612161 ccgattgctt ttgctgtatc catggagctt ccgcctccga ctgccaccaa accattacag 2612221 ttctcttttt tgtaaagctc agatccttca ttcaccagac ggacaggcgg gtttggctca 2612281 actttattaa agagtaccac ttcaatgcct gcttctttaa gtgattcgat tacgggatca 2612341 gcaacaccgg ctttataaat cccagggtct gtgacaagga gcgcttttga aacgcccagt 2612401 gcagctactt cctcacccgt atgcttgatg gctccgattc catgcttaat cacagtcgga 2612461 atttcaaatg tgtggaattt ctgcatgctt tctaccttca tatttaatgt catcatcaat 2612521 ctccccctct tatgaattaa accagttaac cgctgccggt tttgtattgc ggtatacatg 2612581 tttgacttct gtgtattctt caaggcctat ttttccaagc tcgcgtccga acccggattg 2612641 cttatatccg ccccatggcg cttgtgcaaa gtacggatga aaatcgttga tccaaacggt 2612701 tcccattctc aagcgggctg ctacccgttc gcacttttca atgtcttttg accataccgc 2612761 tccagccaag ccatagatgg tatcattcgc aagctcgatt acctcttctt cagagctgaa 2612821 ggtttcgact gtcaatacag gaccgaaaac ctcttcctga acgattctca tgtcagaatt 2612881 acagtttgag aaaatagtag gttcatagaa aaagccgttt tgaagctcag gatcttccgg 2612941 gcgtttgcct cctgtctcca gcttcgcgcc ttcctctatt ccgatctcta catatttttc 2613001 tacctttgcc ctgtgctccg ccgaaataag cggaccgctt tctgtctcag catgaaaacc 2613061 gtttccgagt tttatgcgtt ttgcccgttt gaccagctcc gccaaaaatt gatcatgaat 2613121 ggcatcctca acaagcaagc gggaacctgc agagcatact tggccggcgt ggaaaaatac 2613181 agcgtttaag gcctgatcaa ccgcaacttc taaatccgcg tccttgaaaa caatatttgg 2613241 gtttttcccg ccaagttcaa gggcgatttt tttgacgttt ccgcttgccg cccgcatgat 2613301 ttttttgcct gtttcaattc cgcccgtaaa tgaaatcaaa tcgacgtctt tgtttacggc 2613361 aagctcgtcg cccactgtgg ctcccggtcc aagaacaaga tttgcgacac cttttggaac 2613421 accggcttct tccatcagct taaagacttt gattgtcgtc agcggcgtaa tctcactcgg 2613481 cttcatgacg attgtgtttc ctgcggccag tgcaggggcg attttccagc tcgcttgaag 2613541 gagcggataa ttccatggag tgatctggcc gcaaaccccg attggctccc taataatttt 2613601 gctttctgaa tcaggaatcg gagatgaaat gatctctccg ccatctttgt ctgccaagcc 2613661 ggcgtaatat tgaaaaacat tggcgatatc gtccatatcg gccttgcttt cttcgagtgt 2613721 ttttcctgta tcaagagatt caagctcagc cagctcctca agatcgcgtc tgattaattc 2613781 cgcaattttc agaacaattt ttccgcgttc aagcccggat agcgatgacc attctccttt 2613841 gtcaaatgct ctacgtgcgg ctgcgattgc tttgatggcg tcctctcgcc ctccctcgct 2613901 tacagttgca atttcttctt gattaaatgg gttgataata ctgcggatct gttctttttc 2613961 ggcactgatc cattctccgt caatgaataa tgtttgactc atataagcct ccttgacgta 2614021 aataaagttt gttaaataaa aatttaatgt ttttaacaac cttaatctaa catatggttt 2614081 ttaaactgtc aaagtcccat tttgattttt ctttttgact tttcctcatg tttcgttaag 2614141 ataaagaaca taaagaaata acttaacgaa tttaattttc taaaggaaaa gagggtcagt 2614201 atggatgaaa atccagaatt tgcagctata gaacaggctc gggatcttgt tattgactcc 2614261 attgctgaaa cgatggatct ttacggaatt acccgcagtg tcgggatttt atatgggacg 2614321 atgtatatga gggatgagat gacgcttgac gaaatgcgtg aggagttgca aatgagcaaa 2614381 ccaagcatga gcactggcgt caaaaagctt caagacttaa atgtagtgaa aaaaacattt 2614441 caccggggca tccgcaagca tacatttgtg gctgagaagg atttctttaa atttttcaca 2614501 aatttctttc cacctaaatg ggagcgggag gttcaagtga atgtaacagc gatcgaggaa 2614561 gctcaagctg atttacaaaa ggttttatgc aaggaagatc tcgatgagga tatcaaaaat 2614621 gaagcactgc agttatatga tcagctggaa agctctaaag cttactatga ctggctgaaa 2614681 cggcttgctg aatcggtgca gaccggagaa atttttaaat ttataccggt cgaaacaaag 2614741 taaagcagaa aacgcctggg aaactaggcg tttttttgat gtaactacta caaatttgaa 2614801 aaatacggga aaaacacccc atttacttcc aaaatatttg atggtaattt tatgtaggta 2614861 aaatttgtat ttggcctttc agaggaggtg aaaagcgggc aggcctgttt aatttatcat 2614921 tttttagggg gaattttgtt atgaaacgca aattattatc ttctttggca attagtgcat 2614981 taagtctcgg gttactcgtt tctgcaccta cagcttcttt cgcggctgaa tctacatcaa 2615041 ctaaagctca tactgaatcc actatgagaa cacagtctac agcttcattg ttcgcaacaa 2615101 tcactggcgc cagcaaaacg gaatggtctt tctcagatat cgaattgact taccgtccaa 2615161 acacgcttct cagccttggc gttatggagt ttacattgcc aagcggattt actgcaaaca 2615221 cgaaagacac attgaacgga aatgccttgc gtacaacaca gatcctcaat aacgggaaaa 2615281 cagtaagagt tcctttggca cttgatttgt taggagctgg cgaattcaaa ttaaaactga 2615341 ataacaaaac acttcctgcc gctggtacat atactttccg tgcggagaat aaatcattaa 2615401 gcatcggaaa taaattttac gcagaagcca gcattgacgt ggctaagcgc agcactcctc 2615461 cgactcagcc ttgcggttgc aactaatgta aaagaccggt taacgccggt cttttttgcg 2615521 ttttaccctc ccctttttct ctaatccccg ttatcttttt tctggtttaa aatttaaatt 2615581 gacaaacact agaaacagga gtaaattctt gagtgttcaa tttcatacag tctcttttac 2615641 cgcttaatca aacacgaacg ggggaaccaa cgattggctg ttttattaac agccttgggg 2615701 tgaatcttac taagtaagag ggggtactct gaatccctaa tccgacagct aacctcgtag 2615761 gcgtatacag agaggaggtc tattatcggc cattctttgc aatggtcttt tttgtttcaa 2615821 aaacgttaat tcactaaggg agatatgaac attgggaaga attaaaaata agcaatttgc 2615881 cgtgatcggg ctgggccggt ttggcggcag catttgtaaa gaacttcata gaatggggca 2615941 tgaggtcctt gcggttgata tcaacgaaga aaaggtcaat gcatatgctt cttacgccac 2616001 tcatgcggta attgccaacg ccaccgaaga aaacgaattg ctttcattag gaatacgcaa 2616061 ttttgaatat gtgattgttg ccatcggagc aaatattcaa gcgagtacgc tgaccaccct 2616121 attattaaag gagcttgata ttccaaatat ttgggtgaag gctcaaaact attatcatca 2616181 caaggtgctt gaaaaaatag gcgctgaccg cattattcat cctgaaaaag atatgggggt 2616241 taaaatcgca caaagccttt cagacgaaaa tgttttgaat tacattgatc tatctgatga 2616301 atacagtatt gtcgagctgc tggctacgcg caagcttgat tcaaaatcga ttattgacct 2616361 gaatgtaaga gcaaagtacg gctgcacgat cctggccatt aaacatcatg gagatatctg 2616421 tctttccccc gcgcctgaag acatcattcg cgagcaagat tgcctggtga tcatgggcca 2616481 caaaaaggat attaaacgtt ttgaaaacga agggatgtag acaaaggtga cacttcaaaa 2616541 ggataaagtg atcaaatggg ttcggtttac accgcctcaa gtgcttgcca ttggtttttt 2616601 ccttaccatt atcatcgggg ctgtcctatt aatgcttccg atttccacta cgaagccatt 2616661 gtcatggata gatgcccttt ttactgcggc ttccgctaca actgttacag ggcttgctgt 2616721 tgtcgatacc ggcactcaat ttacggtatt cgggcaaaca gtaattatgg ggctgattca 2616781 gattggcggg cttggattta tgacatttgc ggtcttgatc gtcatgatat taggaaaaaa 2616841 aatcggctta aaagaacgaa tgctcgtcca ggaagcctta aaccagccga caatcggcgg 2616901 tgtcattggc cttgtcaaag tcctgtttct gttttcgatc agtattgaat tgatagcagc 2616961 actcatttta tccatccggc ttgtacctca atacggctgg tcatccggct tgtttgcaag 2617021 tttgtttcac gcaatatctg cttttaacaa tgccgggttt tcgttgtggc ctgataattt 2617081 gatgagctac gttggcgatc ctacagtgaa cctcgtgatt actttcttat ttattacagg 2617141 agggatcgga tttacggttc tgtttgatgt gatgaaaaat cggcgtttta aaactttttc 2617201 tttacataca aagctcatgc ttacaggaac gctgatgttg aatgcgatcg ctatgcttac 2617261 ggtctttatt ttagaataca gcaaccccgg cacgctcggc cacctgcata tagtggataa 2617321 actgtgggcc tcctattttc aggcagtgac gccgagaacc gcagggttca attctctaga 2617381 ttttggaagc atgagagaag gaacaattgt atttacttta ttattgatgt ttatcggagc 2617441 aggaagcgca tcaacggcga gcggcattaa gctgactacg ttcatcgtga ttttaacatc 2617501 tgttattgct tacttgagag gtaaaaaaga aacggttatt ttccgccgtt ccatcaaata 2617561 tccgattatc attaaagctt tagctgtgag cgtcaccagt ttgttcatcg tgtttttagg 2617621 gattttcgcc ctgacgatca cagaacaagc gccatttctt caaattgtgt ttgaaacctt 2617681 ttccgcattc ggaactgtcg gccttacgat ggggcttact cctgaactga caacagctgg 2617741 caagtgtatc atcattgtca tcatgtttat cggaagaatt ggtcctttaa cgttcgtgtt 2617801 ttcattcgca aaaacagagc aatcaaatat ccgttatcct gatggcgaag tgtttacagg 2617861 gtgatatcaa aaaaatccgg cgtgcagtcg ccggattttt tatgattcga tatgagattg 2617921 attttgtctt ttttcctgtt ccgcgatgat ttcgttatcc tccgcgttat cacgggtcac 2617981 tttttgcgta agaatcgcac caactgctac aagtatcata acagcgatgt aataaccttt 2618041 ttcattgagt tccagattat cagcattata gagtccgata ctaaacaaaa atactcccgc 2618101 aaaaaaagta aaataagcta gtactgtaaa ggcaaccgtg tttctgcgtc tatatttctg 2618161 cacctttgtt ccctcccgaa agcatagtta aaaagtgata acttccgtgg aatattatac 2618221 ctcaaattcc ccggaatgga acaaagaatt aaaaatacca gtaaaaaggg cttaggttgc 2618281 ctcctttatt tcaacagctg aatcatcaat ccagccgata agtttatcat tgatttggaa 2618341 ttggtaccat acagactggc ctttctgttt tttagacaca acctttatgt ctttgccgac 2618401 gtaagattgg gcagaggtaa gccttatgga ccgatcatca gtagaaggct tggaccatac 2618461 gtcttgaacg gcactgtctt taatagaggc gtttaaatcc acagatttga gggatggatt 2618521 tacctcatcg tactcatcta aatcgtattt ttccacaata gcgctgattt tgtcagcgta 2618581 gtcagggtct gtagcatatc ctgatgtttg cagggcggtt gccgcttcct tataattccc 2618641 tgcctcaagc accggtttat acttcttttt attccacgat gtgccacgga cgaacaattg 2618701 ggcgtgatca tccatagatt caaaaaacgt gctgtatttt cgaaacttcg cgcgaatggt 2618761 ttttcttttc cctttttcaa cttcgtccgt ttccatcgtg acatgatggc ctttataatt 2618821 cccttttacg ccaaaaaggt tgttggcctt agcagccagt tcactgttcc cccagtccga 2618881 ttcgagaatg gcctgagcaa ttgtgatgct ggggagaaca tggtattttt catacaaaat 2618941 ttgggcatgt ccggacagac tgtctataaa tacttgctgt tcatcgattt cttcagtttc 2619001 tttggatatt tcaatcggtt ttgataaagt tgtcgctaaa acaaacagag ctagcggaat 2619061 cgatacaagg aaaaatagtg aaatcaagag tttacgtttt ttaagttttt tacgggccat 2619121 gaaaaccttc cttcgaatta aaagattacg aatgtaaaag aatctacctt ttagaatttt 2619181 acttgcactt ctaatatttt tcaattcttt agggataaag ttgggaaaag attgcaaaat 2619241 aaaaaccttt tcgctcaatg aaaaggtttt taccatgttt ctatttttgt aaatttctga 2619301 gtgcattccg atattccgta tcatttatta ctttatatga tttgacagtt gccttcgaca 2619361 aaccttgtgc tgagacggcc ggtttttccg gagctgtttt cgctttatca tgtggtttat 2619421 gtgccagctt gtgccccatt ccagtggcat tcatacaaaa tgacaggcag acgagcagca 2619481 cgctaaggat aaaagaaatg aagaagagat catgataagc agtcatcata gaatcctgta 2619541 ccgaaccgct ttgtctggca gcatcttttt tcgtgaaaaa gccgatgaga atgggaactc 2619601 ccatatagac aaacaatctt aaaaactgaa cagctgtcat tctcttgacc aaatcaggca 2619661 gcgggcctcc catggcagct cccatcagcc ctgcggcgac tgtcaggcct gttcccgctg 2619721 caagcatgat aaacagtgcc gcgaacatat aaagagatga tcgatcctgt atatgcagcc 2619781 attgaaaatt cacaaaaacg agaatgagtc cgccgataat accgagcatc cctggtccga 2619841 ctttatcgta taacagagcg ctcaaaatgg ccgcgatcgc cactccgatt aaaagagtca 2619901 agcttaaaag aatgagatgc tcctgagaaa tatcatacat ttgacggagc aagccttgaa 2619961 aagcagaaag gctgacagct accgttatcg tccctgcagc tatgatcaat aagccgagca 2620021 ccggttttgg cagcagcatc agtttaatag atatgaaggg gtttttcact ttatattcca 2620081 caatcaatag accaatgagc aaacataacg tcaccccgaa accaatccat acataacccg 2620141 atgacagccc ccatttttgc agaaaaatga atgaaaccgc tgaggctgcg gcaaggaaga 2620201 cagataaaag aattcccgca cgatcaagcg gctgttcttg atccgccgct ccgtgatgct 2620261 catcatgaag aaagaaatag ctcaccgcga caccgatcag ggacaaggtg ccaaagatga 2620321 aaaacagcca tctccaatgc ccgcagcttg ttgcaatggt tcccaggatt gtaccgatga 2620381 taacagaacc atagaatccc ccgatcagca caagcagtgc atagttcctg cgttcaatcg 2620441 ggaatgacag tacaagcatt ggaatcataa tcatcagcat gacgcctgtt gccgcccctt 2620501 gtaaaaagcg ccctgccgcc atcaatgcaa tatcgcctga acatgcgatg agcagtgagc 2620561 ctagtataaa gacaggtaat gaagccagat agacgggacg agcaccgaat tttttcctca 2620621 gcagcggtcc tgccggaact aacaaggcaa aggccatatt gccgatcaat atcggattta 2620681 ctgatgtaaa gacacttgtt ccaaccgttt tctgaacaag gccttgaact gacgacaatg 2620741 ccgtgttaga catcaatccc ggcccgaccg ctaagacggc gagcaaagaa atcacccaat 2620801 agtgttttgt cttcatgttg tcatcccttc ctatatgaat acatgcgaaa cacatcattt 2620861 tttgaaaaca aaagaagcta atagattttg cataccatta gctttcattc taatattctc 2620921 cctttcaggg gaaatgatat tattttatta taattatgtg aatgaatgag catataatca 2620981 aatattattt caaatcgatt gtgttttgtc aatggagtaa atttcaagca caacatagaa 2621041 agcttgaaag cttttccccg atattgtgtc tagaactgca cttatgaatc cctgctcgtt 2621101 ccctcaagcg aattaaagca ggccgtttta atcctttcaa tccactattc caactaataa 2621161 actcaaataa gttggtgata agacaacatt ttacccccac atttttttgt gttcactggg 2621221 cgtttgccgc ctctaaattg tatatgggta aataccatga attaacctat gaaataccaa 2621281 tgtaagggag gcaaaaacga atggaactgt atgagtgtat ccaagacatt tttggcggct 2621341 tgaaaaatcc atcggttaaa gatttagcaa cgtctttaaa acaaattcca aacgcagcaa 2621401 aattgagtca accgtatatt aaggaaccag accagtacgc ttacggccga aatgccatct 2621461 atcgaaataa tgaattggaa attatcgtga ttaacattcc gccaaacaag gagacaacag 2621521 tacacgatca tggtcaatcc attggttgtg caatggtgtt agaaggaaag cttcttaatt 2621581 ctatttatcg ttcaaccggc gaacacgcag aactctccaa ttcatacttt gtccacgaag 2621641 gagaatgcct tatttcaacc aaaggtttaa ttcacaaaat gtccaatcca acatctgaac 2621701 gaatggtgtc tcttcatgtc tactcccctc ctttggaaga catgacggtc tttgaggaac 2621761 aaaaggaggt attggaaaat tcatgattga cagataaact gctcactttg acttcactca 2621821 actggaggat tcagagaatg aaaccttttc ctcaaaacaa aaaaaccctt atcgaataag 2621881 ggtttaaagg tatggagcca agggggctcg aacccctgac ctctacgctg ccagcgtagc 2621941 gctctcccag ctgagctatg gccccgtatg taacgtcatg tttattatag atgattttat 2622001 tttgaaaaac aagctgtttc ctcttgaatt gacagaaaaa ataaggctcg gaaaagagcc 2622061 ttatttttcg acttacatca tgatcaaaag taaaatcaca ccgagaataa ttcgatagat 2622121 tgcaaatggg acaagtttga ttttgttaat cagccttaag aagaaacgga cgacaaacag 2622181 tgcgaccaca aaggcacaga taaagccgac gatgaaaaac ggcatcagat ccgaacttaa 2622241 gctgtcccaa tgcttcacga ggcttagaaa gctggctccc atcatgatcg gcatcgccat 2622301 aataaacgta aagtcggctg cagctcggtg gtttaatccg agaataacac cgccggaaat 2622361 ggttgaaccc gaacgcgaga aaccaggcca aagggaaaga cattggaata agccgacggc 2622421 tatcgcctgt ttataggaaa tgcggtcgag tgtgtctgtc gctgttttcc gtttattgac 2622481 ccagtcagca aaaagcatga ggattgcccc ggcaattaaa ccgatggcca cagttttaac 2622541 ggaaaataaa tattcatcaa tgtaatcttc aaacaaaaag ccgagaacag ctgcaggcac 2622601 gagtccgacg gcaatttggg caatgcttaa tttatgtccc tgctcctggt cgcttgtaat 2622661 attttttttc aagcccagta aatttaaaat tcggtcttta aacacgatag ctactgctaa 2622721 aatggagcct agctgaataa ccaccttgaa tgagttagca gcttcttctg acatcagatt 2622781 acttgatttt agccagatgt cgtctactat gatcatatgt cctgtcgaag aaaccggcgc 2622841 gtactctgtt aatccttcta cgattcctaa aatggcggct acaaacaatt cccatagagt 2622901 catgattttg attctcccca ttagacattt atttttttac ataacgggag cttcccataa 2622961 atggaaagcc cgtcttatat aactataaac gaaaatcaca ctttatgccc cggcgtattt 2623021 tcattttttt cttcatcgta taaatgtgac tgcattttaa accagtcaaa taaatgtgtc 2623081 gtaatgactt tggcaaccgc atagccggga atcgcaagaa tgattccaac aacgccaaac 2623141 agcttgccgg ctgttaacag cagaaaaata atcgtaatcg gatggatgtg aaggtttttt 2623201 cccataattt gcggagagat cagcttccct tcaatcagct gaacaatcgt ccaaacgatc 2623261 accagcttaa gcagcatgag cggcgatgtc actatggcaa tgataatcgc aggcgtaatg 2623321 gcaatcgttg gccctaaata tggaacgatg cttgtgcaag ccgcaatgac tgcaagcaat 2623381 gaagcataat ccagcccgat aatcaaataa ccgataaaca gcaaaaaccc gatacagaag 2623441 ctgacaatga tctggcctct gatataagag cttaaccgat gattcatttc gcttaagact 2623501 gtatatgtct gttctttcaa tcgagtcggc acaaacttca gtatgtagac cggtaatttt 2623561 cttccgtctt ttagcaaata aaatagaata aacggaaccg tgacgatcga aatgataatc 2623621 tcagtcagtg cgccgataaa attcccaaca ccggtaaagg tgctgttcac gatcgtcgct 2623681 gcctgatccg aaacctttgt agcaagatca gatatattaa tgttcatcgt ttgctgggcc 2623741 tgattgacga agttgctgcc aatcagctgt ttcgtctgat tttctacgac gtccacatat 2623801 ctcgggatat tgtcaatcaa actcataatt tgttctttta agaagggaat gatcgacacg 2623861 atcgtgatcg tgatcagccc gataaccaat aggtatagca gcaatataga atagattctt 2623921 cttattcttc ttctctccag aaaatcgacg actgggttta acagataaaa aacaatgcct 2623981 gtcaaaataa tcggaagtga tatcgttttg agcagaacaa taatcggggt gaaaataaat 2624041 gatgtttttg taaatactag aatatttaaa ccaatcagca gcagcacaag caaaaataaa 2624101 acaaacttat tatccaagaa gaatcgcttg aatctgccgc tccatgtttg caacgtctcc 2624161 actatcgttc ctccgtcata catagtttaa ttaaattgta cactatcgtc cctataatga 2624221 aaaataaaaa ccgttaattg ctggaaaagc tttctcggtt ttaacattct atttatatct 2624281 atcatgtgat tttgttcttt ttaagctata atttagctat atcatgcaaa aggagcgata 2624341 cgagtgatac gttttgcaat aataggaacc aactggatta cagaccgctt tcttgagtca 2624401 gcagcggata tcgaagattt tcagctgact gctgtttatt caagatcggc tgaacgcgct 2624461 ggcgagtttg ctgctaaaca caacgctgcg catgccttct cagaccttca ggaaatggcg 2624521 gcgagcgatt gctttgatgc cgtatacata gcgagcccga acgctcttca caaggaacaa 2624581 gccgttctct ttatgaacca tggcaagcat gtgctttgtg agaagccgtt tgcttcgaat 2624641 acaaaagaaa cagaagagat gatctcagcg gctaaggcaa acggcgttgt tctcatggaa 2624701 gcaatgaaga ccactttcct gccgaatttc aaagaactga aaaaacacct gcataaaatc 2624761 ggcactgtcc gcagatttac cgcaagctac tgccagtatt cctcacgata tgacgcgttc 2624821 agaagcggaa ctgttttgaa tgcgtttcag cctgagcttt ccaatgggtc attaatggat 2624881 attggcgtct attgtattta tccggctgtt gtgttgtttg gcgcgccgaa ggatgtaaaa 2624941 gcaaacggat atgctttatc ctccggagtg gacggagaag gaactgtcat tctgtcttac 2625001 gacgggttcg aagctgttct gatgcattcc aaaatctcta cttcctatgc cccggctgaa 2625061 atccagggtg aagacgggac gattgtaatc gatacgattc accggcctga acgtgttgaa 2625121 atccgctacc gggacggccg ccttgaaaac atcgcgatcc ctgatcctaa accggcgatg 2625181 ttctatgaag cagaagaatt tgtcacgctt ataaaagaga ataagctgga atctgaagaa 2625241 aatacatttg aacggtcttt gaccaccgca aaaattatgg aagaagcaag aaagcaaatg 2625301 gggattgtat accctgctga tcaagcttaa aaaaatccgc ccgcgtgcaa atgccgcggc 2625361 ggatttttta ttagacaatc ggagaagatg ccttcctttt taaaagcacc tgttgctcat 2625421 attctttgat gtcataaagc catgcctctt ttaccggaac gcccatttgc tcacagtagg 2625481 aatcccagat ggctccgaaa ggatatgttt tgaattcctc catcagggcc agcctttctg 2625541 tatagcggcc ctcttcctgc aattgtttta aatatccgtt cgggagaagc agggcataca 2625601 ataaagcttt gatcatattt ctcgttccga tggtccaggc ggctacacgg ttaatgctgg 2625661 catcgaaaaa atccagaccg atggctacct tctcaagagc atgatttcgt acaatttcaa 2625721 gagcgatttc tctcaattca tcatccaaaa ccactacatg gtcgctatcc caacgaacag 2625781 gccgcgatac gtgcaaggca agcttgtctg tgtaaagcag catggacgag atcttgtttg 2625841 ataccgtctc agtcggatgg aaatggcctg tatcaagtaa acaaagctta tgattcgtca 2625901 aagcataagc taaataaaat tcatgagatc cgacaacata tgattcggag ccaagcccga 2625961 acagcttgct ctcgattgaa tcaagattat gttgttcact gatctcctct gagaagatcc 2626021 gatccagtga ttcttttagt cttttacgcg gtgtcagcct atcactcggg atatccttat 2626081 agccgtcggg aatccaaata ttcgtcaagc aaggtgttcc taattctttc ccgaagtatt 2626141 ccccgatacg gcggcaagcg atgcaatgcc tgatccaaaa ttctctgatg tccggatcag 2626201 ggtgtgaaag ggtgagtccg tcagccgctt tctcatgcga aaacaaggtt ggattaaaat 2626261 ctaaaccgag accaaggttt tttgcccatt tcacccagtt ttcaaaatgc tgcggcttca 2626321 attcgtcacg ttctaccgct tccctgtttg tttctgcgta tatcgcatgc aggtttacgc 2626381 ggtgctttcc aggaatgaga gaaagagcct tctccaaatc tcttcttaat tcttcaggag 2626441 tttgcgcttt tccgggataa ttgccggtca cgtcaattcc gcctgaaagc tcgcccttat 2626501 ttacttcaaa gccttcaatg tcgtcaccct gccagcagtg gatcgaaatg ggcacttgct 2626561 ctaattgccg aagcgcctct tcaacatcaa ttccccattt ttcatatgcc tgttttgcac 2626621 tgtcataatt ggcttttatg gtcatacggc tctctccctt tatcagtttt tcaatccaaa 2626681 taaaaaactt cctttagatc tatcgcaaca ggactgaaat ccgaatttgt tttcattaat 2626741 ggcgccatcg atttccacca tctttggcaa acttccgtgt ccgccatctt tctccatttc 2626801 tcttcatcct ctatttctaa atatgcaaaa agcctgcctg tttcctcgtc tagaaaaatg 2626861 gaataatggt gtgctccatg agctttgagt gcttctgcca tctcaggcca aatgtcatca 2626921 tgccgctgtt tgtattcttc gtacttgtct tgatggacaa acatgatact ggcttttctt 2626981 ttcaaacctt ttcacctctt catcatttag atagcgcttt caaaacagtt tgctgaaatg 2627041 actgaatgat cgtgcttcta tcaatgtctt taggtgtaaa cactttgatc ggaaaggaat 2627101 ttctgacgac ttgccgggct tcttttatgt ctttgacttc tttggcagca atcatttgca 2627161 tcaaaagatt tccggtggca gttgcctcta tcggccctgc atataccgct tttccactca 2627221 tgtctgccgt taattgattt aagaaatcat tccgggctcc gccgccgatg atatgaaatt 2627281 gctcgatcgg tttttctgtg attgtttcga gctctttgat ggctatcgca tagatgatgg 2627341 ctaaattgct gtagatgcag caggcaagtt cgcctgcagt acggggaatc ttttggcggg 2627401 tttgtctgca ataatgttgt atttccttta tcatgttttc tggattcagg aaacgtttat 2627461 catttaagtt tataaattgc tggaatggtt ctgttttttt ggcttcttct gcaagctgct 2627521 gaaaagaata atctgcttgt agctgctgtt tgacttcttg tatcacccac atgccgataa 2627581 tgtttttgag aaagcgaatg gtgttgtttg cgccgcgttc atttgtatag ttgttttcta 2627641 aagcaagatc agttattatc ggtgttttgt tttcaacccc gattaacgac catgttccgc 2627701 tgctgatata cgcccagcca tcatttacgc ctggcgccgc aatgacggcc gaggccgtat 2627761 catgtgttgc gactgtcatc accttgcacg ccgggagatc ataatccggg aaccactcat 2627821 ttcttagctt cccgagttca caccccggtt cagtgagcgg cgcaaattgc tgttccagaa 2627881 cagacacggc ttcaagcaat tcaggatcaa gatttcccgt tgagacgttt aaaagctgtg 2627941 ttgtggacac gtttgtgatt tccgttacag cttttccggt taaacaatag cctaaataat 2628001 caggaatcat cataattttg tctgtctttt tcagcagctc acggtcttct tcaaacaatt 2628061 gatagatcgt gttgaaaggc tgaaattgta ttcctgtttt ttgataaatt gcggcttttg 2628121 agagggtatg ttccagtttg tctattgtgt gatctgttct tctatcacgg taggagattg 2628181 cttcccgcaa ccgatcgcct ttttcgtcca gtaagacata atcgactgcc catgtatcaa 2628241 tgcctacggt gcagtgttca tacccaagcg tctttacttt ttgcagtcct tgcaggattt 2628301 gttttagcaa atgatcaata tcccataagc aatgcccgtc tctttgactg aaaccgttag 2628361 cgaacctgtg aatctcttgt atgtcaagct tcccttcatt cagttcacct accatgattc 2628421 tcccgcttga tgcgcctaca tcaatggcag tataaatcat cctttcaccc tctcttcgaa 2628481 agaggaacag ctgtcacctt cacctttttg tcctcaagag cttttaccga tgccggatca 2628541 agtccagaat ccgtaataag gcggctgaca tcttgcagcg aggcgatatg tgaaaactcg 2628601 cggttccccc atttgcttga atcggccatc aaaatggtct ggtccgacct ttcgatcatc 2628661 cgttttttga gcagcgcctg ccactcattt gaatcactca tcccgttgtg tacgtcaaat 2628721 cccttacatg acagaaaggt tttattgaca tgataggtct caagtgaacg ctctgctaac 2628781 gggccggcaa atgataatga tttttccagc aaaatgccgc ctgttgaaat gactgatatg 2628841 ttttctttat tgctgagttc aatagctgct ttcattgagt ttgtaatcac ggtgagctca 2628901 atgtcaggga gtatttttgc catgtaccaa gcggttgtgc ttgcatcgag aatgattcgg 2628961 tctccgcttt ttacatattt ggccgcttcg tgagcgatgg cttttttttc gatgacattc 2629021 gtgatttccc gttcagaaaa atgaatttct gattccttct gctgaatact gaccgctcct 2629081 ccgtggctcc ggctcagttt atgttctttt tcaagctttt caagatcacg ccgaatggtt 2629141 tcctctgtga ctgaaaaaat gtcacttaat tcggaaacgc ggatgcttga acgcatattt 2629201 actatttcca ctattttttg ctgccgttct gctactagca tcggtaacgc ccttcctcat 2629261 atcgtagtcc gtcttatatt tttatcatag catatatcta acgcgtaaaa gcagcaggga 2629321 cgccgccgtc taccgtgatc atgcagcccg ttgttttttc ggctttggaa gaagcgaaga 2629381 atgcaatggc ttcggcaata tcctccgggt aaatattgac gagcaatgct gtccgtttcc 2629441 ggtaatgttc ctccagctga tccggttcaa tcccgtacgc cgcggctcgt tcctcacgcc 2629501 agcttgaacc ccagattgcc gatccttgaa gaactgcatc aggcaaaacg gagttgaccc 2629561 taatgccgaa ttctccgcct tctgctgcga tgcatcttgc taaatgggtt tcaagcgcct 2629621 taacagagct gtaggcagag gcgttttttc ccgcataaac tgaatttttc gatccgacaa 2629681 ataccatgct tccgcctcta ttttgatgtt tcatctgttt aaacgcttca cgggctacaa 2629741 ggaaatagcc tgttcctaaa acattcatat taagattcca ttcttttaga cttgtttcgt 2629801 caaatgggct tgatgtggcc agcccggcat tattgacgac gatatcaatg ccgccgtaag 2629861 caagcgccgc tcgttcaaaa gctgactgta cgtcttcctc ctttgtcaca tccattttga 2629921 cagccattgc ccgtcctttt ccgtatgcat cgtttatttc cccggcaatt ttctgtgcgc 2629981 cttctatatt cagatcagct acgatcacgt gccctccctc agctgcaaat cggcggcatg 2630041 ccgcactgcc gattccgccg gctcctccag ttatcagcgc tacttttcgg gaaaattctg 2630101 cttccggcgg ggccagcgtg agtttatata gttcgagcgg ccaatattcg acatggtagg 2630161 actcattttc atgtaaagaa acaaattgcc ccagagcggt tgctcctttc attacggcga 2630221 tggccctccg atataaagcc ccgcttactt tagacatcgc ataacttttt cctgtattca 2630281 ccattccgat tccaggaatc aatatcaccc gcggggcgga ttcaaagatt tgatccccat 2630341 cctgctgatt gcgtgtaaag taagcctgat actctgatgt aaaggtctcg actcctgact 2630401 tgatcagatc tgcaagcttg tgcacatctt gagtttccgg attccaatca atgtacagcg 2630461 gaacccgttt tgtgtgaaca aggtgatccg ggcatgccgc accgatttgc gaaagtgctg 2630521 gcgcttggac actgtttaca aattccaaga catcgtcatg atcatcatag gaaaggatca 2630581 ttttcttttc ttcacttact gctcctctga tcacaggcat gatgcctgcc aagatttgtt 2630641 ttcttttatc ctccggcagc ggctgatacc ttttgcctcc gaatacctca tgctgattga 2630701 tacgatcgtt aatatactgc tcggcttctt gaatgatgga tatcgttttt tgataacatg 2630761 tttcagacgt ctctccccaa gtgactaagc cgtgtttctc cattaataca agctcggcgt 2630821 gggggttgtt tgctacgcct tcagcgatca ttttagacaa agtaaatcca ggacggacgt 2630881 atggcaccca tacaaaccga tttccgtaaa tgtcttcagc gatttgtttt ccattatccg 2630941 cacagcatat gctgataatc gcatctggat gggtatggtc aacatgtttg tatggcagaa 2631001 aagcgtgtaa tagcgtttca attgaagggc ggggatgttt gctgtctatc atacaatgag 2631061 acaggtagtc taccatttct tcatcgggca tttggtccct tttaatcagc gggcggatat 2631121 catctaattt caaaccggaa aagttatgcg ctttcattgt tgccaaatcc gatccgcttc 2631181 cttttaccca catgacttct atttcacggc ctctaaaatc cttttccgtt gttttcatag 2631241 atgtattccc cccgccccag ttgcagacag tgcggtctga cccgatcaga ttggacctgt 2631301 acaccaattc ctctacacct ttaggtagct gtgcagctcg ctctgaatcc catatatgtt 2631361 tcaccatatt tgatattcct ccataccctt ttatttgtat ccgttttcat tatatatgat 2631421 ttctgtttgt ttttgaatcg tttttgttta tttttgcttt ttaacaaaaa aagaaagcag 2631481 cagatatgcc gctttctcgt ttcattatga ttctatttta aatttcttcg taatgtcctg 2631541 aagttcttcc gccatgtttg ccaacgtttc cgctgaagag ctgatttctt ccatggacgc 2631601 aagctgttct tccgccgaag ctgcgatatc ctgaatgcct gctgagcttt ctttcgccac 2631661 tgcagaaata tcttcaacag cacttgacac ttcctgtgat ccggctgaca gttgttcaac 2631721 cgtcgcgttc aagttttgca attcgccgga aatttgggtt gtcatctcat agatttgttt 2631781 aaagctttcc gctgtttgat ccgtaatctg caagccttct ttcacttcat gattcacgga 2631841 ttggaacatt gaaagtgagg tgctgatttc cctgacaatc tcttgaatta atccttcaat 2631901 ttccttggcg gagtctgctg attgtacagc aagttttcta acctcttccg caactactga 2631961 gaaacctctt ccgtattctc ccgctcttgc cgcctcaatc gcagcattta atgcaagcag 2632021 gttggtttga tcagcaatgc cgttaatcac attcaagatg cttgtgatgt cttgcgattt 2632081 tgtttcaagg cccttcacaa ccgcttccgc tttttgaacg gattggtcaa ttgttttcat 2632141 ctggccgact gtatgctcca ccagcttttc tccgctgccc gctgcctcag aggactgaat 2632201 cgatgatttc gtaatggttg aagaggcttg agccactttt gaaatcccct cgttcatttg 2632261 agaaagatga tttgagcttg tttccagttt ctcgctttgt gcctcgttgc catctgagaa 2632321 ctgttcgatg gcaagtgtaa tatgttcagt tgccttgctt gtttgggctg cgcttgctgt 2632381 cagctcctca gaagatgaag cgacgttttc tacagacgtt tgaataacgc ctattacaga 2632441 acgcaatgat gcagacattt cattaaagct ttcgccaagc tggccaaact cgtttttcga 2632501 gtgaatgtca atgacttctg tgagatctcc gctgctgatt tttgcagacg ttgagacaag 2632561 ttttcttaac ggcttggtga tggcacggat aatatagagt atgagtatgc cgccgattac 2632621 tattgacacg catagaatga taaccgcagt gttcagcacc gggcttgaag catcttgcaa 2632681 ttcactgaca aaatatgtgc ccgcgatttt ccagccagtc agtttatttg tcgtaaaggc 2632741 cattttcttt tctttgcctt cgaatgtata ttcaaatgag ccttcttttt tggaatatac 2632801 ttggtttgtc caatcgccgg aaccggttgt ccccggctta atggtcggat gggcgatata 2632861 ttttttgttg cctgtcgtaa taaatgcaaa gccttctttt ccgattttga ttctttttga 2632921 tgcagtaagc acttcatcca ggtttaaatc tagcgctata acccctgaac cgtcttttaa 2632981 ttgttttgaa attgtgacaa cgatatctcc tgtcgcttca tcggtatacg gttctgagaa 2633041 aacagcttgt cctttttccg caaccgcctg tttgtaccag tcacgtcctg tcggatcgaa 2633101 acctttcgga acaccgctat ccggatattt ataaagcttc ttatcttctg aggcagcata 2633161 gattgcgcct acatcgtcgt taagtgtcgt gtactgctta aatttctctt tcagtaatgt 2633221 tttgtttttg cctaacaata tgtctttatc gactgtctca ctataataat ctattgcttt 2633281 tactttatct tctaatttat tttgcagcgt actgtttagt tcttcaacat ttcccttcgc 2633341 actgcttatg agctctctgt ctaacgcgtt ccaagctgat tgataactga aatatgctaa 2633401 aaccccaacc ggcaaaataa gcactgccag aaacgcagcg attagcggtt tgctgatcga 2633461 tggctgtttg atccattgta tgaattttcc cattctcgtt gactcctcct ttaagataaa 2633521 tctaatatcg tcaaactagg ataaaaggtt taataaaaaa actaaaaaaa acacccaagc 2633581 gcaacaagct tgggtgttaa ggcttattat tcaattttaa atcgtttggt catatcccga 2633641 agctcttccg ccatagagga aagggtctct gcagacgagc tgatttcttc catggaagct 2633701 agctgctctt cagctgacgc cgcgatatct tgtatatgcg ctgagctttc ttttgaaatc 2633761 gatgcaatgt gctcagacgc tcccgaaact tcttcggagc tggcagaaag ctgctgaacc 2633821 gtcgcactca tattttgcag ttcgccggcg atttggttcg tcatttcaga aatgcgtttg 2633881 aagctcattt ctgttttatc tgtgatgtca agtcctgtct gcacctcttg attgacagat 2633941 tggaacatgc cgagtgatgt attgatttcc ttcacaattt cgatgattaa tccttcaatc 2634001 tcttttgctg aatctgctga ctgtactgcc agttttctta cttcttccgc tacaacggag 2634061 aagccgcggc cgtactcgcc tgcgcgcgct gcttcaattg ctgcgtttaa ggcaagcagg 2634121 ttcgtctggt ctgcgatgcc gttgatcaca cgcaaaatgt ttgtaatatc tttcgatttc 2634181 gtttccaatc cgcgtacgac ttgctccgct tctttaacgg acttgtcaat gacattcatt 2634241 tggccgacgg tttgatgaac aagcttgccg ccttcacttg caatttctgt cgattgaaca 2634301 gatgaatcag tgatcacttc agaagcttga gccatattcg tcaacccgtc attcatttga 2634361 taaatgtgct ctgctgccgt ttcaatgttt tcgttttgtt tttcattgcc gttagaaaat 2634421 tgttcaatcg ccaatgtaat gtgctctgtt gccttgctcg tttgcgcagc tgatgcagtc 2634481 agctcctcag aggaagcggc aacattgtct accgaatcct ggatggcgtg tatgagagaa 2634541 cgaagtgacg acgccatatt gttaaagctt ttgccgagct cgcccaattc atcttttgaa 2634601 cggatatcaa tggtttccgt caaatctccc tcgctgatcc gcttagagga accgacaagc 2634661 tgtttcagcg gtgttgtaat cgaccgaatg atcaatgtca tgacgataat ccctatgata 2634721 atagctgcgg ccaagacaat taaagcaagg tgaaggacag gctgggctgc ctcatggatt 2634781 tcatccaaat acatggtgcc gccgatcttc catcccgtca acttgtttgt gtcaaaggcc 2634841 atttttttct tatcgccatc catggtgtat tgaaaatcgc ctttatcagc actcaacatc 2634901 ttatcgagcc agtcgccttt taattcagtt cctgattgtt cattagggtg tgcgacaact 2634961 tttttgtcct tcgtcatgat aaatgcgtag ccttgtgtgc cgatgttgac ttttttggtt 2635021 gttttcagca gattttcaat cgtcatgttg attgcgataa cgcctgaacc atcttttgtc 2635081 tgctgggcga ttgtcacaac catcgtattt gtcgacgcgg ttttataagg gtctgtgatc 2635141 acgactttcc ctttatttgc aaccgctttt ttgtaccagt cgcgttcaac cggattatag 2635201 ccgcttggca tcggaagatc cggatagcgg gtaaagtgcc cttttgtgtc acttgtataa 2635261 atggattcta catccttgtt aatgctgata tattgtgaga atttctctgc aatgcttgca 2635321 ttgctttttg cattgtattt ctcttttgtc agccattcgc tgaaataatc agcactgttt 2635381 tctttttcgc cgatgctggt gttaatgatt tcgtttaatt gctgtacatt ttccaatgcg 2635441 ctccccatca tctgtctgtc gagtgagctg ctagccgatt gatacgcaaa gatcgccaat 2635501 atgacaaccg gtatgatgag gatcgacaga aaggaaacga gaagcttccg tgtaattgat 2635561 ctttgtttta tgagttggag tatttttttc atcattcatt tctccttttt tatgctaccc 2635621 ttcatatcgg ctggaaatgg gtaaatatat acagcaaaaa agaagaaatt taacaaaagt 2635681 aactaatttc ccataaataa atagtatttt agacctatta tttgtctact ttaaattgtt 2635741 ttgtcagatc acggagttct tcagacattc tttcaagcgt cagtgcagat gaactaatct 2635801 cctccatgga tgccagctgt tcctcagctg aagcggcgat atcttggatg ccatccgagc 2635861 tttccttaga aatggcagtg atatcatttg aagctgcgga aatttcttga gctcccgctg 2635921 acagctcctc aaccgtcgca ttcatgtttt gcagctcgga agcaatttga ttggtcattt 2635981 gcgatatatg tttgaagctc tgtttagttt catccgtcat gacaagccct gtttcaactt 2636041 ctttgtttac ggactgaagc acgttcagtg atgtgtgaat ttcttttact atttcactga 2636101 tcagcgattc aatttctttt gctgagtcag ccgactgtac cgcgagcttt ctcacttcct 2636161 cagcgacgac tgagaagccc cggccgtatt cacccgctct ggcagcttca atggcggcat 2636221 ttaaagccaa aagattggtt tgatccgcaa tgccgttgat gacacgcaaa atattcgtga 2636281 tatcctttga tttgatctcc agccctttca ccacttgttc cgctgctttt acggaatggt 2636341 caattgtgtt catttggccg gctgttttct ggacgagtgt ctcccctttg cttgacactt 2636401 cggttgaatc tgcggatgtt tctgtaatca ctgctgcagc ccgcgccagc tctgccaatc 2636461 cgtcattcat ttcattaatt tgttcggttg tcgtttctat tttctcgctt tggctttcac 2636521 tgccgtttga aaattgctcg atagccatcg taatgtgctc agtggctctg cttgtctggt 2636581 ctgccgatgc agtcagctct tcagacgagg aggcaacgtg ttctactgag tctttgatcc 2636641 cgtgaatgag cgagcgaagc gagtgtgcca tatgattgaa gctctcactc agaacgccga 2636701 gttcatcttt tgaattgatt tcaatcgttt cggttagatc gccttcacta attttttcag 2636761 cggatgcgac aatgcgtctc aatggctttg tgatggatcg aatcacaaaa taaatcgccg 2636821 tcattccagc tccgatggca atcgccagaa cgattgaagc catgatcaga accctgcttg 2636881 cagcatcgtg aatctcgttt gcatacatcg tgccgctgat tttccagcct gttgtttggc 2636941 ttgttgcaaa tgccattttt ttctttttgc ctttgtacgt atattcaaag tccccgcttt 2637001 tatccttgta gagcttatca acccagtccc cttttagctc tgttcccgct ttttctccgg 2637061 agtaggcgat gactttcttg ttttggctca aaataaaagc atagccttct tttccgatat 2637121 tgattccttt cgcggtagtg actaagtcat caattttcat atcaatggcg acaacgcctg 2637181 acccatccac cgtttgacgg gcgatggtga cgaccatttt tcctgatgaa atcgattcat 2637241 aaggctcagt gacaattgtt ttgcctttat tggccattgc ttctttgtac caatctcgtt 2637301 ccaaagcatt aaagtcgctt ggcatgtcag cgtacggata acgtgtgaag tccccgtctt 2637361 tgccgcttga aaataccgca gcgacattat cattcatttg gataaattgt ttaaattcct 2637421 gtttcagctc tgttttcttt ttatcctgaa atttttctgc tgtagcccaa tcgctgaaat 2637481 atgcgaggct tttttcagta gtgctgattt tatcatcaat gatgtgatct aatatctgaa 2637541 cattttcctt tgcgctttgc gtcatctgta catcaagtga ggcaactgct gattgataag 2637601 cgctaaccga aagggcggtt atcggaacaa ttaagatcag caggaaagaa ataataagtc 2637661 tccttgcaat tgatgatctg cgaatagtgg tgagtgtttt tttcatttcc ttttgaacct 2637721 tctttcaata atttacaaat tatatcggcg gatcttcctt taaattacat tgaaaatgga 2637781 ggaaaaaatg aaaaatagtt ctaaattcac ctgttaaact aggactttat tattgtttac 2637841 catataaaaa aacagcgctt tgatagcgct gtttttcggt ttttactcga ttttaaattg 2637901 tttcgtcaga tcgcgaagct cttctgccat ctgcgcaaga gtcgtcgctg aggaactgat 2637961 ttcttccatg gaagcaagct gttcttcagc tgatgcggca atgtcctgga tgcttgccga 2638021 gctttctttc gacacgtctg caatgccgct gactgctgct gaaacatgct gtgaacggtc 2638081 tgacagctgc tcgacggtgg aattcatcgt ctgcagcttg cccgcgattt cgtttgtcat 2638141 gctgaaaatg ctctggaagc tttcttttgt attgtctgtg acaacaagtc cggactgtac 2638201 ttcctgattg acctctttaa acatgtgaag agaggtgtcg atttctgcga cgatttcttg 2638261 gatcagcttt tcgatttctt tcgctgaatc ggctgattgg acagccagct tgcgcacctc 2638321 ctccgctacg acagagaagc cgcgtcctga ctctccggca cgcgccgctt caatggctgc 2638381 atttagtgca agcagatttg tttggtcagc gattccgttg atgactctca aaatgcttgt 2638441 gatgtctttt gattttcctt ctaagccttt gacaacagct tcagcctgct gaacagattg 2638501 attaatcgag ttcatttgtc cgactgtctg ctgcacaaac ttctcacccg ttccggcgat 2638561 ttccgttgat tggatagatg cctttgtaat atctgacgat gtttgtgaga cttgctggag 2638621 tccttcattc attaagttca gctgatgaga gctggattca accttttcgc tttgctcctc 2638681 gtttccgttt gagaactgct caatcgccat cgtaatatgc tcggtggctt tactcgtctg 2638741 cccggcagat gcggtaagct gttcggaaga tgcggccaca ttgttcaccg agtcctgaat 2638801 agcgctgatc agagagcgga gagattgtcc catttcattg aagctttccc caagctctcc 2638861 aagctcatcc tttgaatgga tttcgatcgt ttcggtcaga tcccccctgc tgatcgtttt 2638921 cgatgattga acaagacgtt ttaacggttt tgtaatcgaa cgaacgataa acagaattaa 2638981 aattccgcct gccacaatgg aagcaatcag cacaatcatt cctgttgtca gcacagactt 2639041 tgaggcatcc ttaatttcat ccatatacat tgtgccggct attttccaac cagtcagttc 2639101 gtttgtagta taggtcatct ttttatcttc gttattaaga gtatactgga gttcaccgct 2639161 gtcattcgca tacattttgg ctacccagtc gcctgaaagc ttttctccag ccttatggtt 2639221 cttgtgggcg acataggttt tgttttttgt tgcaatgaaa gcataacctt cttttccgac 2639281 cttgatttgt ttcatttgtt ctaacaattt atcaatggta atatccatgg cgacaacgcc 2639341 agatccgtcc ttcagctcct gtgcaatggt aatgaccatg cttccgtcac tcgcagccac 2639401 gtaaggatct gtcacgacaa tttcaccgcc ggccttcatc gcatcctggt accaaggccg 2639461 ttgtctcggg tcgtatcctt ccggcaattt ttcttttggc gcttgtacat aagtgccgtt 2639521 atctgcgccc ccataaattc tggctactcc ttgattaata gatacatatt gtgaaaattt 2639581 agctttgatc tcttcttgat ttgatttccc tttgaatgcg gatcttttaa gagattcact 2639641 gaaaaaggtg actgctttcg ctttttctcc cagatcattt gtaacagttg tattaaatgt 2639701 atcgacactg tttttcgcat ttcccataat ttcctgatcc agctttccgc tggcgcttcg 2639761 gtaagagcta aattctaata taagaatagg gataatgaga atcgcaataa atgagacgat 2639821 taatttcttt gaaatagacg gtttcttcag ccaattgata aaagtcttca tgtcacttgc 2639881 tccttcaggt ttgatacagt atatatcggc tgcttaaaaa agttttaaaa taaaaaatgg 2639941 aagaagttct ttttggctgt cttctgcctt tttaactttc attgcccaag ctctttgcat 2640001 atcttataaa aaacaagggg ggctaaacat gattattgta tcaggacaat tgctccgtcc 2640061 ccaggatatt gaaaattggc agattgatca agatctgaat ccgctcttaa aagagatgat 2640121 tgagacgcct gttcagtttg attatcattc aattgctgaa ctgatgtttg agcttaaact 2640181 gcggatgaat attgtagcag cggcaaagac gctgcacaaa agcggggcga agtttgccac 2640241 ttttttaaaa acatacggga atacaacgta ttggagggtt tcaccggagg gcgccttgga 2640301 gctgaaatac agaatgccgc cttcaaaagc gattcgggac attgcagaga acggcccgtt 2640361 ttatgcgttt gaatgcgcaa ccgcaatcgt tatcatttat tacttggcct taatcgatac 2640421 aatcggagaa gataaattca atgccagctt tgacagaatt attttatatg actggcatta 2640481 tgagaaattg ccgatatata cggaaacagg acaccacttt ttccttggag attgtttgta 2640541 ttttaagaat cctgaatttg atccgcaaaa ggcgcaatgg agaggcgaaa atgtgatact 2640601 actgggggaa gataaatatt ttgcccatgg tcttggaatc ttaaacggaa agcaaattat 2640661 tgataagctg aattctttta ggaaaaaagg agccttacag tcagcctacc ttctgtctca 2640721 ggcgaccaga ctggatgttc cgtctctttt ccgcatcgtc cgctaaaaag ccccatcgcc 2640781 tattttccgg acgatggggt ttcaaatgcc tttcgttttc gatagaaggg ggctgtgcca 2640841 aaatattggt tcgcagccca ctccattttt tcaaggtcat ttcttgtcac gattggatcc 2640901 tggctgctcc atttgataaa gcggacaaaa tagtagcctt tgataggaac cattgtaact 2640961 tttgagtgag gccagccttc aaatacaaac tcaattttcc ctcttttttt ataagaatat 2641021 tgaagaatgt tcatatctgt cacctcagtt tatcaagtta cgttcggcaa agctcggtac 2641081 gtttacatcc attgattaac tatccctcat gcaggctttc cggaaaacaa agggtgaggc 2641141 gcgtgtctct ttccctcgct ttttatttcg catatggacg aatgccaagc acgccttcat 2641201 tcgataaagc cgcagcgtgg gcgggtgtga caagccctcc ggctatcggc gcttgttcag 2641261 cgatcatgct tttgtcataa aaaacagcct attatcccat cattttgata tagcatgtcc 2641321 gggtgcgagg cccgtcaaat tcgcagaaat aaatgccctg ccacgttcca agaataagcc 2641381 ggccgttttc cacaatgaca tgctgtgaag ctccgaccgt actcgacttc atgtgtgcag 2641441 ctgtattgcc ctccatatgg cggtccagct catgttccca cggatatacc tcatcaaacc 2641501 ttctgagcat atcttttttg acgtccggat cggcattttc attaattgta atgcccgcag 2641561 tcgtatgcgg acagtaaatc agcgctgcgc cgctcgttat acctgtttct tgaagaaacg 2641621 cttccacctc ccgggtgata tctatcattt catctcgttt ggttgttttg atttgcagtg 2641681 ttttcagcat ttgtttctcc tttcgtttgt ccgctctcat cgcttaattc gttctgtgtt 2641741 cttttttttc ctgttaaacc gctctcataa acccgataaa acaaaaaaac tccagtctaa 2641801 ggctggagtt tagcaccata gatatattct tgcttcatac ggctttaaga gtactgatgt 2641861 catatgcttg tgcggctctg tttcaatatt tgacaagacg agtgcatctg atgacaatgg 2641921 caatccagag tgcctgaaca acgccggtgt tcctgtcaga ttggccgcaa tcagtgcagt 2641981 atggctctcg tttttccgaa gatatgcaaa gatttgctga tcttccggta aaatgagctc 2642041 gtatgtcccg ttaataaaaa catcatatgt ttggcgcagc ttgatcaagc ttttgtaaaa 2642101 atggtaaacg gatgttttat cgtttttttg cgcctcggca ttcagccatt tgtaattctc 2642161 attgattccg atccacggtt tggcctcaga aaatccggcg tatggaccag cattccattg 2642221 catcggcgtt cgcgaattgt ctcttccctt tttccagaca atcttcatca catcctcgtg 2642281 tgatgtgcct ttcgctgttt ttgtttcata caggcgtttc aatgcgacat catcatagtc 2642341 ctcaatagat ggaaaagcca cgttcgtcat cccgagttcc tgtccctgat aaataaacgg 2642401 tgtgcctttc atgagaaaat aaacagcgga aagcgctttt gcactttctt tcaggtacac 2642461 tccgtcgtct ccccacacag aaactgaacg gggctggtcg tgattctcca taaacaaagc 2642521 attccagccg atcccttcca gactgtcctg ccagtcagtt aaaattcgtt taaatgcaac 2642581 gatatcaata ctttcattga tctctacatc ccacaggccg agatgctcaa attgaaaaat 2642641 catgctgaat atgccgtttt tttctccagc ccaatcagct gcttcttttg cagcgacgcc 2642701 gtttgcttca ccaactgtca taatcggata gcgggaaaat gtgttttcct tcagctctgt 2642761 taacaaatcc ataatgccgt cagcattcat atgataagga aaggaaggga catagtccag 2642821 tccctttgga ttcggcatgt caggaaaccc ttcttttttc ttaatatgcg taatggcatc 2642881 cacccgaaat ccgtcaattc ctttatcaag ccaccaattg atcatgtcat aaacggcatt 2642941 cctcaccttt tcattttccc aattcaaatc aggctgtttt ttatcaaaaa ggtgcagata 2643001 atactggctt gtcttttgat catactccca agccggcccg ccgaaaatgc tttcccaatt 2643061 gttgggcgtt tttccgtttt tgccgtcttt ccaaatatac cagtcgcgct tttccgagtg 2643121 tatggatgaa cgggattcta tgaaccatgg atgttcgtcg cttgtgtggt tcacaacgag 2643181 atccataatc agcttcatat ccagatcatg aatgtcacca agcagctcat caaaatcttc 2643241 catcgtgcca aactcgctta atatgttttg ataatccctg atatcatagc cattatcggc 2643301 attcggtgaa tcatacagcg ggcaaatcca tatgacgtca gcgcccagct cttttatgta 2643361 agaaagcttg gttctgattc cttgaatatc cccgattccg tcgccatttg aatctttaaa 2643421 actgcggggg taaatttggt aaactacggc ttccttccac caagcctttt tcatacagcc 2643481 actccttccc agtgtaccgt tcttatatat cctatgtaga aaaaggtctt tacagcattg 2643541 ctttttaaga aatgacttga tgacacaaaa aacagccgtt tgttccccgg ctgtttttta 2643601 tcaaaaatca gtttttttta tttctacaaa acggatgtgg tgatcttcgg cgtcgaggat 2643661 tttaaattca cagccctccg cgtgtatcac atcccctgct ttcagctcca ttttttgcgt 2643721 tagaagccag cctgcaatcg tatcaatttc ttcattttca atcgcaatgt cgagaaggtc 2643781 attcacttcg tctattagcg cttttccatc catcacataa tggtgctcgc cctttttcag 2643841 gatgtgcggt gtttcatcct gatcatactc atcgcggatt tccccgacga tttcctcgat 2643901 aatatcctct acagtgacaa gccccgccgt tcccccgtat tcatcgacaa gaatcgccat 2643961 gtgaatccgc tccttctgca tgcggattaa aagctgctga acaggaatgc tttcaatgac 2644021 tctgataacg ggcctcatga tttgattcag ctttatcggc tggccgagaa aataagcttt 2644081 aaacatatct ttgctgttga tgatccctaa aatatgatcc ttgtcatctt tgatgacagg 2644141 gtagcgtgta taccgttcat taatgatgtg atgaattgcc tcttcaagcg actgctccag 2644201 agagataacc gcaatttctg tccgcggaat cataatctct ctcgctaccc ggttgtcaaa 2644261 ttcaaaaatc ttatttacat agcggaattc agactgattg atttctccct tttcatagct 2644321 ttcagaaagg atcagcctta gttcctcttc gctgatgaca acctgatgct cctttaccga 2644381 atgaaagcca aacaatttca caagaaaact tgcagagccg tttaatgctt taataaacgg 2644441 gtacgtgatt ttataaaacc agatcagcgg ctttgcaatc cataagctta cagcttcagc 2644501 tttttgaata gaaaccgttt tcggggcaag ctcccccatc accacatgca aaaaagtgac 2644561 gatgataaat gcaactacaa atgtgacaat gtggttaaac ggttccggta tgcctgtcat 2644621 tgtaaataag ggatgaagaa aacgttcaaa tgtaggttca ccaagccacc caaggccgag 2644681 ggctgtaatc gtaatcccga gctggcaggc tgataaatac tcgtcaagat tggagatgat 2644741 tttatgtgcg gctagtgctc ggctgtcacc gctttcgatg agctgattga tttttgaacc 2644801 tctgattttg acgatcgcaa attccgctgc aacgaaaaca gccgtaatgc caatcaaaac 2644861 aaaaatggcg atcaattgta aaataagcaa aaaaagccct taccataaat ggtaaggggc 2644921 cacctcctta acgttaattc tcatcacgac cgtttaagaa aatcatcaca aaacgaagta 2644981 gttcaaacag ggaaaccagg gcggcggcca catacgttaa ggcagcagca ctcagcactt 2645041 tatttacccc attttcttca ttgtttcgga tgaatccttc tgacacaata atctgcttcg 2645101 cacgtgaact tgcattgaat tcgacaggca atgtaatcag ctggaaaaag acagccgctg 2645161 aaaacagtat gatgccaagc ccgatcaaat tcaggctgcc gagaagcatg cctcctaaga 2645221 aaagcaaagg agctacaccg gatgcaaaat tcacgactgg gaagatttta tgtctcagca 2645281 caagcgcacc atatgactcc tgatgctgca aggcatgtcc gacttcatgg gaagctacgg 2645341 atatggcgga aattgagcgg ccgtaataga ccggctcaga taaacgcacc acccgtcttg 2645401 tcgggtcgta atggtctgtt aaagtgcctc ttaccggttc gaccggcacg tcgtaaagac 2645461 cgtttatatc taaaatccgt cttgccgttt ctgcccctgt acgtccgctt gaggcttcca 2645521 cttttgaata tttttcaaag ttgctcttta ctttaaattg tgcccaaaac gacaatccca 2645581 atgcggctat tgttaaaaat ataaacagca ttttttcatc atcctttgtt catgatcatt 2645641 tctctattac gattatttta atgagttttc tttctcgtgt acagaaatgc gctttttctt 2645701 ccggcttgga gcacacaatc caatcagcaa aaagaacagg cctgctgaaa acaaataaaa 2645761 ggcgaaactg ccggccagtt ctttcagaaa atgaagccag gagaagcttc cggaaaagtg 2645821 attatatgaa ttcaaatcga aaataaacaa aatcaccgcg gatgccgcca gctgcgtacc 2645881 gattaaaacc acgatcgttc tttgaaagat cgtcatcttt ttcatccttt ttgttttagt 2645941 ttatggagaa atccggtttt atatgttttg tacatttttt gaaaaacatc accggaagtg 2646001 ggacatactg ttagaaaaaa gcacgggtgt gatggaagct atgaaagtga cgagtgagga 2646061 aaaggaacag ctgagcacag caatcgaccg aatgaatgaa ggactggacg cgtttatcca 2646121 gctgtataat gaatcggaaa ttgatgaacc gcttattcag cttgatgatg atacagccga 2646181 gttaatgaag caggcccgag atatgtacgg ccaggaaaag ctaaatgaga aattaaatac 2646241 aattattaaa cagattttat ccatctcagt atctgaagaa ggagaaaaag aatgaaatca 2646301 aatcggatat ttatttcatg gctcaggtgg ccgttattta tccgaatcgg ggttattatt 2646361 ttatgtctga ttcttttgtt cggccaaatc atttatatac ttgagcctaa gcagttcact 2646421 tcggtattcg aaggtatttg gtgggctgtc gttacggttt ctacagtcgg ttatggagac 2646481 tatgtgccgc acactccgct gggacaggca gccggaatac tgctgatttt gagcggagca 2646541 agctttgtca cagcgtattt cgctacgtta tcagcggccg cattcagcag acagcatcgc 2646601 tacattgaag gaaaagttgc ttacaaaggc cgggaccaca tcattctgat cgggtggaat 2646661 gaaaaaacaa accggctttt gaaggacctt cagcttgccg ccccttccaa aacagtcgta 2646721 ctaatcgatg aatccttaac agaaggcccg cttattgaaa acgttcattt catacgcggg 2646781 cacgctgccg atgatgggac actgaaacgg gccaatatta ctgaagcgga atcagtgatg 2646841 attactgccg atcagtataa aagtgaaact gatgctgata tgctgtcagt gctgactctt 2646901 ttatctgtta aaggtcttaa tccccttgct tactgcatcg tcgagatttt aactgaccgt 2646961 tttgtcacca atgcggaacg ggcaggcgca aaccaaatca tcggaacttc agaatttatc 2647021 agccgggcga tgctgcagca ttaccaagtc aagttacggc cgtctaaaca gcagaacgga 2647081 atcaagctga cacttgatca gcatgtggag cttcttgctg ttcctgacga actaaaggga 2647141 gcggcttaca aaacctgtgt tctctatttc cttgatcaca acacaacaat tataggcata 2647201 caaaaaaagg aggggccgat gctttcccct cctcttacat acaaggtgct cgaaacagat 2647261 caattccttg ccatctagtg taacagaaca tcctccaatt ctttcacgag agaggcgccg 2647321 atatccaaaa atgccggatc aatttccgcg tcccgccttt ccggttcgga aaattgatta 2647381 aacagtgatt ggaaaggccc tccctcggcg tgatcgtcaa catccgcctg aaacacctgt 2647441 ctcagcataa atggcgttcc gatccggacg gccgcccctc gttcatcgag actgccctgt 2647501 accgcattga cgggaattct taaaaataaa tagccgtctc tatcatcaat tttataatca 2647561 aagtagccat gatcgtattc ccagccgccg tttatcacat aaccgagcgg cttcatcact 2647621 tgttccagtt cttgaagcag aaaagactgc ccatctatcg cggaaggtat tggtatcatc 2647681 agaatgcccc ttttttcact tatcctgtcc cgccgaacaa gacttcattc agaggcgcct 2647741 acatggaaat cgttgtttct ttcgcgcggc caacaggaaa gaaagcgcat tcaattaaga 2647801 agtaaacagc cattgccgct gcaagccata cagctgaatc ccaagacaca taaacaaccg 2647861 ttgcatagag tcctaattta gtgaaaagag tatgggttcg ttttaaatgc aaaatccgat 2647921 gtaccgcatc ggtaaaaagg gcaagcggca aaccaatgag aagaaaggag tggatgaaaa 2647981 aatgtgacag cgtgccgcca aagcttgaag aaaaccctgt atacacggca tcaaaggaga 2648041 taaggaaact taaaatagct gcagaaaaac cggcaatgat gagatgttta accaattgtt 2648101 tcatgaacat cagcaccttt ctgattttat aaaaagccga ccggcaaatg ccagtcagct 2648161 ttctcacatt aatcttccag acgtttttca agctctgctt ttttctcttc aaagccaggt 2648221 ttgccgagta acgcaaacat attgacttta tacgcttcta caccaggctg gtcaaacgga 2648281 ttgacgccaa ggaggtaacc gctcatcgcg caggcttttt cgaagaaata tacaaggtat 2648341 ccaaaagtat atgcattcag ctcaggaatg ttaacgatta agttcggaac atttccgtct 2648401 gtatgggcaa gcattgtacc ttggaatgct tttttgttaa cgaaatcaac agttttaccg 2648461 gctaaatagt tcaagccgtc aagatcgtta tccgcttcct caattgtcag ttcatgttta 2648521 ggcttctcta cgttcaggac cgtttcgaat aaatctctgc ggccttcttg tacatactgg 2648581 cctaaagaat gaaggtctgt tgaatagttc gctgaagaag gataaatgcc cttctcatct 2648641 ttcccttcgc tttctccgaa cagctgcttc caccattccg caaagtattg aagcgccggt 2648701 tcgtagttga tgagcatttc aattgttttg cccttattat aaaggacatt gcgaacaacc 2648761 gcatattggt atgctgggtt atcttccagt tcagatgttg caaaatcttt gctcgcatcc 2648821 agggcgcctt tcatcatgtc gtcaatgttg acgccgctga cagcaatcgg caagagacct 2648881 acagctgtta aaactgaata acggccgccg acatcgtcag gaattacgaa tgattcaaag 2648941 ccttcttcgt tagaaagcgt ttttaatgcg ccgcgctctt tatcagttgt tgcataaatc 2649001 cgcgctttcg cttcttcttt accgtatttc tcttcaagaa gcttgcggaa aatacggaaa 2649061 gcgattgcag gttcagttgt cgtacctgat ttagaaatca cattaataga gaagtcaaca 2649121 tcttcaagaa gatccatgac gtctctcata taagatgaac tgatgttgtt cccgataaaa 2649181 atgacttgcg gattgccgcg ttttgctttt ggcaaagtgt tataaaacgc gtgattcagc 2649241 gcttcaatcg ctgcccgcgc tccaagataa gaaccgccga tgccgacaac aagcaagaca 2649301 tcagagtcag atttgatttt ttccgcgctt tttttgatgc gcgcgaattc ttctttatca 2649361 taatgttcag ggaggtccac ccagcctaga aaatcgctgc ccgcgcctgt tttctcatgg 2649421 atattatggt gtgctgtttt tacaaagtcc cgcaggtatg taagttcatg ttcgttgaag 2649481 aaagtcaacg cttttgagta gtcaaagcgt acatgcgtca ttgcttgtcc ctccataacg 2649541 gtataatgtt ttcatctttc actttatatg aacttatctg tgaaatcaag tcaagaagaa 2649601 agggcggaat gactggattc cgccctttgg gtttatagag acgcgcgaag gatggcaagc 2649661 acgtcatctt tgttcagttt ttggaagttg ccgaagccgc cgtgttccat ttccttggct 2649721 gcgatatcag caatcagctc aagcttttct tctccaatat tgtaatcagc aagacgagaa 2649781 ggtgcaccga ggcttgtcca gaacgcagac agtttatcga ttccttcaag cgcaatttct 2649841 ttatctgttt tgccttcagt atcaatgtca aacatgttga gcataaggtt tttaaaacgg 2649901 cctacatttg tatcaagcgt gtatctcatc caatttggga acagtattgc caaaccgccc 2649961 gcgtgcggaa tatcatatac agctgaaaca gcgtgttcca ttgtatgaga agcccagtca 2650021 ccgaagtatc ccatttggag cgtgccgttt aaagcaatag taccagcata caaaatcgtt 2650081 tcacgaagtt cgtagttttc cagatcttca agaagcttag gagctgtttc gatgaccgtc 2650141 tgcaaaacag caaagcacat tctatcctga agcggcgtgt tttcaacatt atggaagtat 2650201 tgttcgaata cgtggctcat catgtcaacc atgccgtata ctgtttgatt ttctggaacg 2650261 gtgaacgtat tttcagggtc taaaatagag aaacgcggat gagtgacatt gctgccccat 2650321 acaaatttct cgtttgtttc ccagtttgta atcacggaat cagggttcat ttcagaccct 2650381 gttgcagcaa gagttaaaac agtgccaaac ggcagcgcat cctccgctgt tacttttttg 2650441 ctgaaaatat cccaagcgtc accgtcatat ttgacgccag ctgcgattgc ctttgtacag 2650501 tcaatcacac tgcctccgcc gacagcaagc agaaaatcaa tgtcatgctc tctgcaaagt 2650561 cctatgcctt tttccactgt cgcaagacgc gggtttggct ctacacctga cagctcatga 2650621 acaacagcgc cctcttcttt taaaatgcct gtgacttgat cataaaggcc gttgcgttta 2650681 atgctgccgc ccccgtaaac aagcagtaca ttcttgccgt atcgtttgaa ttcttttctt 2650741 aattgttcaa gctgaccttt tccaaaaatc agctttgtcg gattataata agtgaaattt 2650801 tccatagtaa aacctccaaa tgatgctggt aaaaaacaga ttttccattg taacataagt 2650861 tgacaaaaaa gaaaaaggga agcagccaaa cggctatttc cccttttttt atagtgatgc 2650921 tttcaaaatt gacagcacat cttctttgtt gagtgattta aattggccga atgtaccgtt 2650981 agccattgcc ttgtcagcga ttgtgtcaag ctgctcatca ttaatatcat aatcagcaag 2651041 acggttcgga gcgccaagac ttgtccagaa tgcggacagc ttatcgatac cttcaagggc 2651101 aatttcttca tccgttttac ctgcttcttc aacatcaaac acgcgaactg caagctgttt 2651161 catgcgggca gggttttcag acaatgtgtg tctcatccaa ttcgggaaca gaatcgccag 2651221 tccgccggca tgcggaatat cataaacggc tgatactgca tgttcaatat tatgagtagc 2651281 ccaatcccct cttgccccca tagaaagcat gccgtttaat gcgattgttc ctgtgtacag 2651341 gatcgtctca cgcaattcgt aattttcgag atcattgatc agcttaggcg ctgtttcaat 2651401 gactgtacgc aaaagtgatt cacacatgcg gtcctgatac ggcgtgtttg atacatgatg 2651461 gaagtattgt tcgaatacgt ggctcatcat gtcaaccatc ccgtagatcg tgtggttttt 2651521 aggtacggtg aatgtattca ccggatcaag aatcgagaat ttagggaata cgagcgggct 2651581 gccccagccg tatttttctt ttgtttccca gtttgtaata acagatcctg agttcatttc 2651641 tgaaccagtt gcagcgagag tcaataccgt tccgaatggc aaagcatctt ttggctgatg 2651701 ctttttcgta acgatatccc acgcatcacc atcatacttc gctcctgcgg caatcgcttt 2651761 tgtacagtcg attacgcttc cgcctccgac agccagcaag aaatcaatgt tttgttcttt 2651821 acagatggca acacctttat taacagtcga cacacgagga ttcggttcca cacctgctaa 2651881 ttcatgcacg gtcgctccgg ctttattcag ctgttcaatc acttgatcat acaggccgct 2651941 gcgtttaatg ctgccgcctc cgtacacaag caatacgttt tttccgtaag gtttgagttc 2652001 ctccggaagt ctttccactt cgccgcgccc gaaaattaat ttggtcggat tccagtatgt 2652061 aaagttttgc atgacatctc ctccttagat tttttattat gcagaatgtc ctcaccacat 2652121 gtaaagcaat cagctctcac cgatcagcat accagatggt tttattttgc aaggtgctgg 2652181 gaaagaagct gatataagcg agggcaggcc agcttccctc atatggagaa tgcatgtata 2652241 gattctccaa tatgtcacaa tctataactg ttttaataat tcatggagga ggttgcaaaa 2652301 catgagtacc attcaaagaa tttgtcttgt attaaccatc attggcgcca ttaactgggg 2652361 actgatcgga tttttccaat ttgacttagt agcggctatc ttcggcggcc aagggtcagc 2652421 tctttcccga atcatttacg gacttgtcgg aatcgccggc ttaatcaacc tcggtctgct 2652481 atttaagcca aacgaggaaa gatcacgtga agaagcagca aatcctgaaa tgcgatagga 2652541 tatcaatcac gctgaaatag gattttgcat gaaatcaaaa gcaccgaaca ttcctgtccg 2652601 gtgctttttt catgcttatt ttttgataag gtctttgcgg ttggacattt cgatccactc 2652661 ttcaagctta tcttttaatg tgttgaaacc ttgtggtgta gaagcttctt cgcttacttg 2652721 agcagcttta ggttttcttg gtttgctttc ttttttctca ggcgcagctt gtgtcgcacg 2652781 aattgaaagg ctgattttgc ctttttcttc atcaacagca agtactttta cttgtacttc 2652841 gtcgccaact gaaaggtgct cgttgatatc ttttacgaaa ccgtgagtca cttcagaaat 2652901 gtgtactaaa ccttgagttt cttcatctaa tgcaacaaac gcaccatacg cttgtaatcc 2652961 tgtaacttta ccagtgtaaa cactgcccac ttcaaatttt gctgccattc ataacaactc 2653021 ctaagttaaa ttaaatatct gtttatacgc aatttaaaat tatatcacac atgtcttatt 2653081 tccgcaaaga aaactttttt ataaaaaatc aggtttatgc acagcaaaaa gggggtaaac 2653141 tgaaaatacc aaaggctttc tagtattccc cccttttatt ggatgcgaac aaaaggttcg 2653201 tatctttttt tatgttgttt tgtgcaggaa gcgtttcatt ctgactaacg cttcttgaag 2653261 ctgttcaatc gaggttgcgt atgaacaacg gatatatccc tcaccgctcg gaccaaacac 2653321 acttccagga acaactgcca ctttttcctg cgtcagtagc tcctcggcaa actgttctga 2653381 actcattccc atgcttttga tagatggaaa agcatagaaa gcgccgcccg gatgatgaca 2653441 gctgagaccg atttcattga gcgattctac aaacagattc cgtcttcttc gatagctttt 2653501 tttcattttt tctacgtctt ccatgccgtt cttcaggcct tcaagggcgg caaactgcgc 2653561 cattgcgggc gcgcacatca tcgcatactg atgaatttta agcatggcat cccgaagcaa 2653621 ggatggtgcc gcggcaaaac cgagcctcca gcccgtcatt gcaaatgctt ttgaaaagcc 2653681 tgagatgact accgtccgtt ccttcattcc cggtaatgcc gctatacttg taaattcctc 2653741 atcatatgtc agctccgcgt agatctcgtc ggctaagacg atgacatcat gttttttggc 2653801 aaactcagca atctcattca gctcttcctt cgaataaacc gaacctgtcg gattcgatgg 2653861 tgagcagatg agaatggcct ttgttttttc agtgactgcc gcttcaaaat cagcagccgt 2653921 tgctttaaat cctttgtctg ccgttgtatg aacgtgaacc gggataccgc ctgccaaaga 2653981 aacaagcgca tcgtacgcaa caaaacacgg ctcaggaatg atgacttcct cacctggatt 2654041 cacaatggcg cggatcgcaa tatccaaagc ctgacttgcc cccactgtca caatcagctc 2654101 attatctggc gagtagctaa ggtcaaacct gttgctcaaa taacggctga tttcctcccg 2654161 caatgagtat aaacccgcat tggccgtgta tgacgtatat ccttgttcaa gagagagaat 2654221 gcttgcttcg cggacattcc atgcggtaac aaaatcaggc tcgccgacgc ctaaagaaat 2654281 gacgccttcc atcgttgccg ccaaatcaaa gaatttgcgg atgccggatg gttttatttg 2654341 ttgtacatag tctgataaat acgaagtcat ttacggtgac accacgattc ttttgtcgtc 2654401 gtctcctgtt tcaaacactt tgccgtcatg cttgtatttt ttcaggataa aatgggttgt 2654461 cgtagataca actgaatcaa gcgttgagag tttatccgaa acaaaacgcg ctacgtcaga 2654521 catcgaattg ccgcgaatca cgacagacaa atcgtatacg cctgacatca ggtaaactga 2654581 ttcaacctct tggaatcggt aaatccgttc cgccacttca tcaaaaccga cgccccgctt 2654641 cggcgttact ttgacgtcaa tcatggccgt aacgccctca tgtccgtcga cttttcgcca 2654701 gtcaatcata gcggaataat cgataataac cttttctttc tccagtttgt caataattgt 2654761 tttcacttca tttacaggga tgcccgccat ctttgcgatt gtttctaaat cggcgcggct 2654821 gttttcgtct aaaatttcta atatttctgt ttctttttct gtcaatttca tttgattcac 2654881 acctttgcaa tgtcaagaaa tctcatgaca ttatatcacg ttttttgacg aatgctaaga 2654941 aaaaacgagg agaaacttcc gctagaattg acaatttcag ggcataatac aaccatcaaa 2655001 aaaagggagt gacacagaat ggaggcggtt tcaccaataa ggcggtttac ggtcgatgga 2655061 gtcaatgtat actacgaaca ttatcaaaat cccggcaggc aaacgctggt ctgcgtacac 2655121 ggttttttat catctgcatt cagcttcaga aaagtaattc ctctccttcg ggacaagtac 2655181 gacatcatcg cgcttgattt gcctcctttc ggccaatctg aaaaatcaag aacgtttatc 2655241 tatacctatc aaaaccttgc taagcttgtc attgggattt tggagcactt gcaagtgaaa 2655301 caggctgtgc ttgtcgggca ttctatgggc gggcagatat cgctgtctgc tgctctccaa 2655361 aaacctgagc ttttttcaaa ggttgtgctg ctttgcagtt cagggtattt aaaacgttca 2655421 cacccgacga ttattttcgg gacccatatc ccgtattttc atctttacat caaacgctgg 2655481 ctctcgaaag aaggcgtgat gaaaaattta ttaaatgtgg tgcatgacaa atcgctgatt 2655541 gatgaggaga tgattgacgg ctatggcaga ccgtttcagg acgagcagat tttcaaagcc 2655601 atgacaaggt ttatccgcca cagagaagga gatttagaac ccgagcaatt gaagaaaatg 2655661 aacaagcctg ctctattgat ttggggcgag gaggatcgaa ttgtcccaat ggagatcggt 2655721 aaacggctgc acgcagattt gcctaattcc gtgctgtact cacttggcca gaccggacat 2655781 ctggtgcctg aagaacggcc tgaacttatt tctgaacaca ttgctgattt tatcaaataa 2655841 caaaaaaacc ggtgctgaac cggttttttt aaggcgtgca ggagctgctg tttttaatga 2655901 ataaaagctg gccagccact tcccggcagc tggcgatcgg cagcgtttgt tcaaaagaag 2655961 tttcaaatat ttgctgaatg cttttcgcca gcaagtcggg atcgttttca tcatagactg 2656021 cctgcacgac atcaacagcc tccgtttcgt aaaactcttc tccatattta aacgggtccc 2656081 atttggcaat gatcttaatc atttccctga ccgcatgact ttcttccata ttcatcaccg 2656141 cttataataa aatttgcagt tctatcttat catagtgaag cttagaagaa taaacataca 2656201 tgagggggta acagaatgaa ctttgataaa cgagaagaac gccttggcac ccaatcggtc 2656261 aaatgggata aaacaggcga attatttggc gtgacagacg ccctcccgat gtgggtggca 2656321 gatatggatt ttcgcgcccc ggaagcgata actgaagcgt taaaagagcg tcttgaccac 2656381 ggtatttttg gttatacaac tccagatcaa aaaacgaagg atgctgtgtg cggatggatg 2656441 caaaacaggc acggctggaa ggtaaatccg gaaagcatca cattcagccc cggcgttgta 2656501 acagctttga gcatggcggt acaagctttt acggagccgg gcgatcaagt agttgttcag 2656561 cctccagttt atacgccttt ttaccatatg gtggagaaaa acggccggca cattttacat 2656621 aatccgctgc tagaaaaaga cggcgcatat gcaatcgatt ttgaagattt ggagacaaag 2656681 cttagtgacc caagcgttac attgtttatt ttatgcaatc ctcataaccc ttctgggcgt 2656741 tcatggagcc gggaagattt actgaagcta ggcgaattgt gccttgagca tggcgtcaca 2656801 gttgtatcgg atgaaatcca ttccgattta atgctgtacg gacataaaca cacgccgttc 2656861 gcttcgctct ctgacgattt cgctgatatt tccgtgacat gtgctgctcc aagcaaaaca 2656921 tttaatatcg ccggattgca ggcttcagcg atcattattc cggatcgcct gaagcgcgcc 2656981 aagttttccg caagccttca gcgaaatggt ttaggcggac tgaacgcgtt tgccgtcact 2657041 gcaatcgaag ccgcgtattc aaaaggcgga ccgtggcttg atgaattgat cacttacatt 2657101 gagaaaaaca tgaacgaagc ggaagccttt ttgagcaccg agctgccaaa ggtcaaaatg 2657161 atgaagccgg atgcatcata cttgatttgg ctcgacttca gcgcttacgg cttgtccgat 2657221 gcagagcttc agcaaagaat gctaaaaaaa ggaaaagtta ttttagagcc cgggacgaaa 2657281 tacgggcctg gcggagaagg atttatgcgc ctgaacgccg gatgctctct tgcaaccctg 2657341 caggacggcc tgcgccgcat caaagccgca ttatcgtaaa tatagctgta aacgccttta 2657401 cgtcttcatt tgtaaaggcg ttcttaataa aggaatttta tattttactt ctaatattta 2657461 gtgttataat agattcatat tttatacgaa aggatttcac acgaatggaa attctaaaag 2657521 actatcttct gcacatctgc tttattttgt ttcctattct tctttaccaa gtgttttggc 2657581 ttggaaaacc tgcgattctt gtgccaaaaa taaacagcgg tttggtcacg ctcttcgcct 2657641 gcggcgcctc cgttttatgc attattttcc cgattcatga aatggactac atacaatacg 2657701 gccttcagat gattcccgtt atcatttgtt tattttacat tagtaccgct tccggactta 2657761 cagtcgccgc atctgtccta tgttttgaac tgctttttta cgaaccttcc gcaatgtttg 2657821 ttttcacttt gctgcctttt cttatcatta tcccaatctt atttcagaaa aaatggccat 2657881 tcatgtccaa agcgaaaaaa ctgctgctgt ctttattgat cagctgcgtg gagattttcc 2657941 tatttttcgc ctcaagctgg attctttccg ccttgaatat tttaaatttt caaaaatcag 2658001 gaattttcgt ttacgaggcg gcagtctcag ggcttttccg ctccagtgtt cttctattaa 2658061 gcatctatat tatcgaaagc atcgccgaaa atatcgccct gcgttcacag cttatccatt 2658121 ctgaaaaaat gacgattgtg agtgaactgg cagcgagcgt cgcccatgag gtcaggaatc 2658181 cgctgacagt tgtccgcggg tttgtccagc tgctttttaa tgacgaaacc ctacaaaaca 2658241 agtcgagtgc ggattacaaa aagcttgtac tgtcagagct tgaccgggcg caaggcatta 2658301 tcacaaacta tctcgatatg gccaaacagc aattatacga aaaagaggtt tttgacctat 2658361 ctgcccttat caaagagaca agctccctta tggtgtcgta cgccaattac aagtcagtaa 2658421 ccgtcgaggc tgaaacagaa ccggaccttt tgatatacgg agacgcaaca aagctgaagc 2658481 aggctgtcat caacctgatg aaaaacagta ttgaagcggt tcctcacggg aaggggatga 2658541 tccacatatc agccaaaaga aacggccata cgatcatgat taacatcaca gacaatgggg 2658601 tcgggatgac agaccatcaa atgcaaaaac tcggcgaacc ttattattcc ttaaaaacga 2658661 acggaacggg actcggcctc accgtaacct tttccattat tgaacatcat cacgggacca 2658721 tttcatttaa cagcagcttc caaaaaggca ctacggtgac cattaagctt cccgctgatc 2658781 ttcctcacta gcaaatcgat tggaacttta atagaataaa tgcgaggtga tgacagatga 2658841 gcacgtttga gacaggctct atcgttaaag gattttacaa aacaggtgta tacataggag 2658901 aaatcacggc ttgcaggccg cagcattatt tagtgaaagt gaaagcggtt cttacccatc 2658961 ccgctcaggg agaccttcat catccaaaac aggcggatgt gccatttttt catgagagaa 2659021 aagcgctcgc atatggtgaa cagaccaata tcccccacca tatggtgaag ccttatgacg 2659081 gtgaagtgcc ggattatacc gaatctctgc gggaggcgac agcacagatg agagccaaat 2659141 tgaatgagga tggttcggag tgggcaaagc gctcccttca taatctggac attttagaaa 2659201 aagaatattt taaccggcca taacccagtc tgacaaaaga ttgggttttt tacgtcgcgc 2659261 gcttcaacag ttcggttaaa tcgattctct cgccgattgt gggcggtttt ggcttttcga 2659321 gatactgctt atcctgctca acaagcttaa aaagtttata tgctgtgaga gcatcatcaa 2659381 gcgctttatg atgggtgccg gttccggaat ctccatactc ttcggcagct ttccataaac 2659441 ccgtcaatgt ccggtctcca aaaaagtttt tgtattcaag cgataaatct ctcatttctc 2659501 ccttaaacgg gaaagggata tggttaaaca tacagttttg cttcagcact ttcatatcca 2659561 tgtttcccca cgtaataatt gtgctgtttt tctcaggatc cagctcgttt agtttacgga 2659621 tgaaatcctc gaatctcatt ccttcgtcta cctgtttttg ggttattttt aaaaatgatt 2659681 tgcagcgttt cgtaagcttc gggaactttt tcggtctaac atagctagaa aacgtctcaa 2659741 ccacttcatc atcaatcgac tttacaattc cggcttcaat gatttccggg aagaagtttt 2659801 gaggactgta ctttccatca ggcattgtaa attcgaaatc aataatgagt aagctgtttg 2659861 tcgtcacctt ttacacctgc ctttcctccg atcagaaaat gctatcttta tagtatatca 2659921 attccccttc tcgacatttc ttcattttct aaaaataatg aattttccca gccgcttcgt 2659981 ttcttttaaa ttgtgaatcg tttctttata attagtaagg aacccgaaat aataagaagg 2660041 tgatgttatt tctatccgta agaaaaactt tgtcattgtg tggctggcga acttttttgt 2660101 ctccgctagc acaacgatga tcgttccttt tctctcctta tacattgaga cgctcagctc 2660161 tttttcaaac ggctttgtgc aaaggtggag cggctatgtg ttcggcatta catttctcat 2660221 ggcgtttttg gtatccccgt tttggggacg gttcggagac aaacgcggat acaagaaaat 2660281 ccttatggca accggaacag gcattgccct cagcattttc ttcatgggct ttgttacatc 2660341 ggtgtaccaa ttgttttttc tgcgtatggc aatgggtctt gtaaccggat tcatcccgac 2660401 atctcttgcg atgatttcgg cacagactcc gaagagctca gctggcaaaa cactcggcac 2660461 gctgcaaatg gggcaagtgt ccggaagctt gttcggcccg cttttgggag gcatgcttgc 2660521 tgatcgtttc ggctttacgt ataccttttt tatcacatcc tttgtgattt tctcgtctgt 2660581 tcttctcgtg ttatttggtg tcaaagaaaa gcatcttgca gagaaaacag ccaaacgtac 2660641 gtcttactcg agaaaagaag tgctctccta tatttttcac catccggcgc tgtgggtcat 2660701 gatgctgtta accatgctga ttcaaacagg caatttcagt atccagcccc tgctcgcttt 2660761 atatgtaaat gagctgcacg gacctgtcaa tcttgccttt ttctccggca tggcattttc 2660821 agcaacgggg ctcggaagtt tgctgctggc tagaaaatgg ggtgatctgg gcgaccgcta 2660881 cggccaccgc cgcattttaa tcggactttt gctcgccgcc tctttctttt ttattccgca 2660941 ggcgctcgcg tcctcactca gcgtgctcct tgttttcaga tttttattcg gaatggcgat 2661001 gggcggtttg ctgccatgca ttacggcagc gatccgcgtt caggctcccg gcagcattca 2661061 aggtgaagtt ctcggctaca atgtcagctt tcgcttttta ggaaacgtgc tcgggcctct 2661121 gctcggcgga atcatatcga gccattttac catttcggcc accttttacg tcacggcgtt 2661181 tctctttttc gccggcgcct gcatgctttg gatcatgcag aaacttcgga aagattctta 2661241 tgccaaagca agctgattcc gagaaaaaac taaggaatct tctaaattta accttctcgt 2661301 aatctcaaaa gaatggtacg atatggctag aatttaggag aaaagagagt gaccatgtta 2661361 cgaaaaataa tcggatggat tttgctcctt tgcataatcc cattgtttgc atttacagtt 2661421 atcgcttccg gaaaagaagt aaaacaaatg aagtccctgg atcaggtgct tgataaaaat 2661481 attgatctga aagatatcag ccttgttcag aacagctaca tgtatgacag ggacggctcc 2661541 cttgtctcgg aaatcgtcag cgaccacgaa aaccgtgtgc tcgttccatt taacaagatt 2661601 cccgaggaag tcaaacagat tttcttaaca tctgaggacc gccattttta cgagcataaa 2661661 ggctttgact ttatgggaat ggtgcgggct actgcttcta acgtaaaaga caagaaaatt 2661721 gaccagggtg ccagcaccat cacacagcag ctttcaagaa acttgtattt gagccacgaa 2661781 cgctccttca gccgcaagct gacagagctc gcgtattcct atcagctgga gaaaaaatat 2661841 acgaaaaatg aaattcttga agcttactta aataccattt atttcaacaa cggtgtttac 2661901 ggcgtcggtt cagcagctca attctatttc agcaaaccgc tgaaatctct cacagtggga 2661961 gaaatggctt ttatctgtgc tatacctaat aaccctacat tatatgatcc tctcaagcat 2662021 tttgactaca cgaaaagccg tcaagaacgt ttacttaaag ggctaaaaga tgccggggtc 2662081 attacggaca aagagctgaa aaaagccgta aaacaaaaaa tcaaactgga tgttgaaaaa 2662141 agagaagaca aatatcctga ctacgtttcc tacgtcaatg atgaattcac tcagctggtg 2662201 tctgaatcag aaggctttga taaacgcctt caaaaagcat caggaaaaca aaaagaaaag 2662261 atcgagaacg agctgtccgc aagagtcagc acgctgatga aagacggagt gaaaatttat 2662321 actgcacttg atccgtacat gcaaaatcaa gttgtggcac aaatgaattc caagctcccg 2662381 tatgcggacg tacagggcgg agcggctgtg attaatcacc agacgcatca aatcattgct 2662441 ctatccggcg ggaaaaacta tcaaaaatat gactttaacc gcgcctacca ggcgtacagg 2662501 cagccgggtt catccattaa gccgcttctt gattacggcc cttatattga acagaccggc 2662561 gcgacaacaa gcagcaccat tgatgccagc aagttttgca gcaaagacta ctgtccgcaa 2662621 aactacaata accgcactta cggcacagtg acgcttgata cggcgtttaa aaattcatat 2662681 aataccccgg ctattagaat gctcgaccgc gtcggcatcc aaaaggcatt cagttatatt 2662741 gagccgtatc attttgccaa acttgtcgac agtgactatc ttcttccggc ggcgcttggc 2662801 ggatttacaa acggcatgac gcctcttgag atgacaaagg cttatacgac attcggaaac 2662861 agcggaagct atacgccgag ccatgcgatt acaaaggtga cagaccttaa aggaaaaaca 2662921 ctttataaat ggaatgataa agcgactcaa atattcagcg tccgcacgaa catgcagctg 2662981 aaaaaactga tgtcttccgt tgtgaaaagc ggaacaggga aaaaagcata tttcaatgcg 2663041 ccttacatcg gcggtaaaac cggaacatca aatgattatc acgatatgtg gtttgtcggc 2663101 ctgactgata cgtatacaat gggtgtctgg gtcggaaagg atacaccgac cagcgttgaa 2663161 tatcttcaca gcatcagccc tcagctttcc atctggaaag gaacgctgca agcggcttat 2663221 taaaggatcg gaggggatat ggagtgactt cagaacaaat tccaaatcgc gttttgctgt 2663281 ttgacggtgt ctgcaattta tgcaatggcg ccgtgcagtt tatcattaaa cgtgatccgg 2663341 acggattgat ttctttcaca tcgctgcagt cggaaacagg acagagcctg ctgaaaaaaa 2663401 gcgggcttcc gactgatcgg tttgacagct ttgtctttat tgaagacggc caagtgtaca 2663461 caaagtcaac tgcagccatt aaggttttca ggcatctgcg aggcccatgg cggctcttcg 2663521 tccttttttt cgcagtgccg aagcctgtca gagatatggt ctattctttc attgccaaaa 2663581 accgctataa gtggtttggc aaaaaaaatg aatgtatgct cccctcccct tccattaaaa 2663641 aaagattttt accgtaaata aaaaatggct aggaagctag ccatcacaga ttgttgacaa 2663701 aatcctaaaa cggcttcgtt ttaggatttt gtcatctatt cagcgtgatt gaaaactttt 2663761 gaagttgtga aacggcggaa acctgagaat ctagccgccg tttcattgcg tacagagcac 2663821 gaagcgcaaa tctgaccacc aaacgctgaa atggctagct tacacaggta agctagccat 2663881 tatgctatta taaagcttga taaatatgaa cagaataccg ataacaaagg taaaccaaaa 2663941 cagcagttcc aatagaatga atccaactaa tgacatgaga gaaagcgtcg aataaatccg 2664001 gtatacggta aacacaaagt aagcgagcgt gacgaccgca aaccagatca caatccaaat 2664061 gacattttgc aagagcacaa aggataaaat cccgccgccc aaataaatca tggaacccat 2664121 tctgagtttt ttcaggttgt tcccttccgg atcattagca aaaaacagca atgacagctc 2664181 ggtcacggta tttgcaatta atttcagagc ggacagaacc ataaaatata aaagtgcaaa 2664241 ggcagcaaat aacgcaagcc tgattccttt ctctgaaaaa taatcgagca ttccatcata 2664301 cattccaaat gaagacagca tcttcaacgc ataaagtgaa gttgagatgg ataaggacga 2664361 actaaaaagc aggatcgcaa tcagcggaaa atatcctgtc aaataagtat ttttcatata 2664421 aaaaagtccc tttctataat ctacctcatt tattatggag gacttaaaac acattgacaa 2664481 gataaattat tccatttttt ctccttttta cgaattacgg gcccaaatct tcacaaagca 2664541 gcattttgag agtaaagtag tacgcaggaa tcataaaacg taaggaagtt ttatatgaaa 2664601 aaaacattaa aactgcaaac cagactcacc atatttgttt gtatcgttgt attaatcgca 2664661 ttgctcatta cgttttttac agtcggtgcc caaaccacca aacgaattag agatcaggaa 2664721 aaggccactg cgctgcagac tgctgaaatg gtagctgaag cgccgatgac agccgctgct 2664781 ttagaaagcg gaaaaaaaca aaaggaactg cagagctaca caaagcgggt tcagaaaatt 2664841 accggcacgg aatttgttgt cgtcatggat atgaacggta tccgcaaaac tcatcctgac 2664901 ccgagcaaaa tcggaaaaaa attcagaggc ggtgatgagt ccgaggtatt aaaagggcat 2664961 gtccatatca gcacagcctc tggcacgctc gggaaatcgc agagagcgtt cgtccctgtc 2665021 tacgcggaga atggaaaaca ggtcggtgca gtcgcggtcg gcatcaccgt aaatgaaatt 2665081 gatgaagtga tcagccatag cttacggccg ctttacttta ttatttgcgt cagcatcttc 2665141 gtcggtgtga tcggagccgt tatcgtcgcc cgtacagtga aaaatatcat gtacggactt 2665201 gaaccttatg aaattgcgac tctgcttgaa gaacggagcg cgatgctgga atcgacgaag 2665261 gaaggaatac tcgctgtcga tgaacatggc aaaattaaac ttgccaacgc ggaagcaaaa 2665321 cgcctattcg tcaaaatggg catcaacaca aatcccattg atcaggatgt agatgacatc 2665381 ttgccgaaaa gccgcttgaa aaaggtcatt gagacaaaaa aacctcttca agacagagac 2665441 gtccgcatta acgggctgga gcttgtgttt aatgaagttc ctatccagct gaaaggacaa 2665501 actgtcggag cgattgcaac attccgcgac aagaccgagg taaaacattt agctgaacag 2665561 ctttccggtg ttaaaatgta tgcaaacgca ctgagagcgc agtctcatga atttatgaac 2665621 aaactgcatg tgatattagg tctcgtccag ctgaaagagt atgatgatct tggagattat 2665681 attaaagata tagccataca gcaaaaatca gaaacaagtg aaattataaa tgatgtcaaa 2665741 agctccgtac tggccggttt tctgcttgga aagcaaagct ttatacgtga gcagggcgca 2665801 aatcttgata ttgaatgcaa cggtgtcatc ccgaacgcgg cagacccttc tgtcatccat 2665861 gaacttatta caatcatcgg aaatctcatc aacaatggct tagatgccgt tgccgatatg 2665921 ccgaaaaaac aaatcaccat gtccatgcgc ttccataaca gcatacttga tattgaaatt 2665981 accgatactg gagcaggcat gtctgaagaa gaccaagcca aagtatttga acaaggctat 2666041 tcaacaaagg gcaaaaaccg gggattcggc ctttatttca cacagcaaag catcgaaaat 2666101 ttaaaaggcc aaatgatcct cacaagcgaa aagaatgaag gaacgacatt cagtattcgc 2666161 atcccgtacg aaccgaagga ggaaaatcat gattaatgta ctaatagttg aagatgaccc 2666221 catggtgggt gaattaaata aacgatactt aagccaaata gatggctttc agctgaaagg 2666281 catcgcttct tcctttcaaa gcgctctgca tattttaggg gagcaccata ttgacctcat 2666341 tttgcttgat atttatatgc cgggaaaaaa cgggctggaa ctgctgacgg aattgagagc 2666401 ccaaaatgaa gcggttgacg tgattgtcat ctcagcggcc agcgagcttg acgtgatcaa 2666461 gaaaacactt cggtacggag ctgttgatta tttaatcaaa ccgtttgaat ttgaacgatt 2666521 ccaaacggct ctgtctgatt acagacgaaa acaaaaggtg tattcaaccc atcgcaacat 2666581 gagccaaaaa gaactggacg ccgagctttt tcaaaagaaa gaagcaacag aaaaagtgca 2666641 gcttcctaaa ggcctgacaa aaagcacgct gaagctgatc tggtccagta tccagtcatt 2666701 tgaaaatgaa tcttttacga cagaagactt ggcaaagcac acagaaatct ctcaagtatc 2666761 catacgaaaa tacttaaagt ttcttgaaga tatacaggtt ctgaatgtag aaatggcgta 2666821 cggaacgatc ggaagacctg tgtttcagta caacgtcaac aacagtaaca ttaacggaat 2666881 aaagcaatat ctataagaaa acgcactgct tgctttgagc agtgcgtttt tctgtcatat 2666941 ctcttgccaa gatgcttgat tctattgttg ataagttata caagaataac aaagggcttt 2667001 cacattttta agcaaataat tctaaaaata gataattttt aaaaaattat gcgaaattct 2667061 atttatttct tattagttaa atgataaatt atgattggtt agttgatccc gaaaaactaa 2667121 gtcataagtc ttacttcaga aaacgatgtc acggttttcc gcccggaacg ccttccgcat 2667181 ccttctcttc cccgcctttc gaaggaaata ctcacaccac gcttattcag ggaagaatag 2667241 aactgtctca gcgcattcca tttgttatta tcagaaaatt ttatcgattc taagaaattg 2667301 ttcaggacag cccatcacat gactggccgg atcagctttg aaccaaattt ttctgggggg 2667361 ttatatcttg aataaacgaa aaatcggatt ggcgatgtca cttgtgatcg cagcaggcac 2667421 catattagga gcatgcggaa acagcgaaaa aagcagcggc tcaggcgaag gcaaaaacaa 2667481 attcagtgtg gcgatggtta ctgacgtagg cggagtggat gacaaatcct tcaaccaatc 2667541 agcctgggaa ggcatccaag cctttgggaa agagaatggg ctgaaaaaag gcaaaaacgg 2667601 ttacgactat cttcaatcca aatctgatgc agactataca acgaacttaa ataaattggc 2667661 gcgtgagaat tttgacttaa tttacggcgt cggctactta atggaggatt caatcagcga 2667721 aattgctgac cagcgtaaaa atacaaactt tgcgattata gatgctgttg tcgataaaga 2667781 caacgtcgca agtattacgt ttaaagagca ggaaggctca tttctcgtcg gagtggccgc 2667841 agccctatca agcaaatcag gaaaaatcgg ctttgtaggc ggcatggaat cagagttgat 2667901 caaaaaattc gaggtcggct tccgtgccgg cgtgcaagca gttaacccta aagccgttgt 2667961 agaagtgaaa tacgcagggg gtttcgataa agccgatgtc ggtaaagcaa ccgccgaaag 2668021 catgtataaa tcaggcgtag atgttattta tcactctgcg ggcgccactg gcacaggcgt 2668081 ctttactgaa gcgaaaaacc tgaaaaaaga agatccaaaa cgcgatgtct gggtcatcgg 2668141 tgtcgataaa gaccaatacg cagaaggcca ggtagaagga acagatgata acgtcaccct 2668201 cacttccatg gtgaaaaaag tagatacagt cgttgaagat gtaacgaaaa aagcgagtga 2668261 cggaaagttc ccgggcggcg aaacacttac ctacgggctt gatcaagacg gagtcggcat 2668321 ttctccatct aaacaaaatc tatcggatga tgtgatcaaa gcggtcgata aatggaagaa 2668381 aaaaatcatc gacggattgg aaatcccggc aactgagaaa gagctgaaaa ccttcaaagc 2668441 tgaataagaa tcgcagggat aaggaggtcg agcccttatc ccttgttttt cttttatttt 2668501 gaaataaagg agcggtcaat caatggaata tgtcattgaa atgctcaata tccgcaaggc 2668561 gtttccaggt atcgtcgcca atgacaatat caatcttcaa gtcaaaaaag gcgaaataca 2668621 cgcgttgctc ggtgaaaacg gagcggggaa atcaacattg atgaatgtcc ttttcgggct 2668681 gtatcagccg gagcggggtg aaattcgggt gcgcggcgag aaggtgcaca tcaacagccc 2668741 gaacaaagcg aatgaccttg gaattggaat ggtgcaccag cactttatgc ttgttgacac 2668801 ctttacagtt gctgaaaata ttattctcgg gaaggagcca aagaagtttg gcagaattga 2668861 ccggaagcgt gctggccaag aggtgcagga catttccgat cgatacggcc tgcagatcca 2668921 tcctgaagca aaagcagctg acatatcagt cggtatgcag cagcgcgcag aaatattaaa 2668981 aaccctctac cgcggtgccg acattctgat ttttgatgaa ccgacggctg ttttgacgcc 2669041 tcatgaaatt aaggaactga tgcaaattat gaagaacctg gtcaaagaag ggaagtccat 2669101 catcttaatc acccataagc tgaaagagat tatggagatt tgtgaccgcg ttacggttat 2669161 ccgtaaagga aaaggcatca aaacccttga tgtccgtgat acaaaccaag acgaactcgc 2669221 cagtctaatg gtcggccgtg aggtatcgtt caaaactgaa aagagagctg ctcagccggg 2669281 agcggaagtg cttgcgattg acggcataac tgtaaaggat acccgcggaa tagagacagt 2669341 cagagatttg tctctttctg tcaaagcggg agaaatagtc ggcatagcag gcgtcgacgg 2669401 aaacgggcaa tctgagctga tcgaagcggt gacaggactc cgcaaaacag attcaggaac 2669461 aatcacctta aacggaaaac agatccaaaa cctgacgcca agaaaaatca ctgaatccgg 2669521 gatcgggcat attcctcagg atcgccataa acacggtctc gtccttgatt ttccaatcgg 2669581 agagaatatc ctgctgcaaa gctattacaa aaagccgtat tcagcattgg gcgttttaca 2669641 taaaggcgaa atgtacaaaa aagcacgcag cctgatcact gagtacgatg tcagaacgcc 2669701 ggatgaatat acacacgctc gggcattgtc aggcggaaac cagcaaaaag cgattatcgg 2669761 gcgggaaata gaccgaaatc ctgatttatt aattgccgcc cagccgactc gcggccttga 2669821 tgtcggagcg attgaatttg tccataaaaa gctcattgag cagcgtgatg ccgggaaagc 2669881 cgttcttctc ctctcgtttg agcttgaaga aattatgaat ctcagtgaca gaatcgccgt 2669941 tatttttgaa ggacgcatta tcgccagcgt taatccgcag gaaaccactg aacaggagct 2670001 tggtctcttg atggcaggaa gcacgcaaaa ggaagcgggg aaagcaaatg gttaaacgac 2670061 tctctcattt actcgtgccg ctcatcgcaa tcatacttgg tcttgcggcc ggcgcgttga 2670121 ttatgcttgt gagcggctac agtgtggcta gcggatattc ggctttgtgg aatgggatat 2670181 tcggagaaat ctattatgtc ggagaaacaa tccggcaaat tacgccttat attttatccg 2670241 gattggctgt cgcctttgca ttccgaaccg gactctttaa tatcggcgtc gagggacagc 2670301 tgctcgtcgg ctggacagca gcggtttggg tcggtacggc gtttgacgga ccggcatata 2670361 ttcacttgcc gctcgcattg attacagcgg cagctgcagg aggattatgg gggtttattc 2670421 ccggcatttt gaaagcgcga ttttacgttc atgaagtcat tgtcaccatt atgatgaatt 2670481 atatcgcgct gcacatgacc aattacatca tttcaaacgt cttgacagat catcaggaca 2670541 agacggggaa aattcacgaa tccgcctccc tccgctctcc ttttcttgaa cagatcaccg 2670601 attactcacg gctgcatttg ggaatcatcg ttgcccttct cgcagcagtt atcatgtggt 2670661 ttatcatcaa caaatctaca aaaggatttg agctccgggc ggtcgggttt aaccagcacg 2670721 cttcccagta tgccggcatg agcgtgcgga agaatatcat gacctccatg cttatctccg 2670781 gcgcttttgc aggtcttgcc ggagccatgg agggcctagg gacattcgaa tacgcagcag 2670841 tgaaaggcgc atttaccggc gtaggctttg acggtatcgc tgtcgctctt ctcgggggaa 2670901 acacagccgt aggcgttgta ctggcagcat gcctgcttgg cgggctgaaa atcggcgcat 2670961 taaatatgcc gattgaatca ggcgttccat cagaggtcgt tgatattgtg attgccatta 2671021 ttattctatt tgtggcttca agctatgcga ttcgtttcgt catgggcaaa ttgaagaaaa 2671081 agggggcgaa ctaagtggac attgtgcaga ttttatctat cattgtccct gccacactcg 2671141 tctatgcggc cccgcttatt ttaactgctc tcggcggcgt gttttccgag agatcaggtg 2671201 tggtgaatat cggcctagaa ggcctcatga ttatcggggc gttcaccagc gtgttattta 2671261 atttattttt tggtcaggaa ttaggtgccg ccgcaccttg gctttcgctc cttgccgcca 2671321 tggcagcagg cgccctgttt tcactgattc acgcggcagc ggcgatttcg tttcgcgccg 2671381 accagacagt cagcggtgtc gccattaaca tgctggcgct tggggcaact ttatttatcg 2671441 tcaaactgat ctacggcaaa gcgcagacag acaaaattcc agagcctttt tataagacga 2671501 aaatccccgg tttgggcgat attcccgtct tgggaaagat cttcttttcg gatgtctatt 2671561 atacgtctat tcttgcaata gcacttgcct ttatttcctg gtttatcttg ttcaaaacgc 2671621 cgttcggcct tcgtatccgt tctgtcggcg agcatccgat ggcggccgat acgatgggaa 2671681 tcaacgtata taaaatgcgc tacatcggcg tgatgatcag cggattgttc ggcggtctcg 2671741 gcggcggcgt atatgcctcc acaattgcgc ttgatttcac gcactctacc atctccgggc 2671801 aaggttttat cgccctggca gcgcttgtat tcggaaaatg gcatccgatc ggagcactgg 2671861 gggccgccct gtttttcgga ttcgcccaaa gcttaagcat cattggatcg ctgctccctc 2671921 tttttaaaga cataccaaat gtgtatatgc tgatggctcc ttatatctta acgattctcg 2671981 ctttaaccgg ctttatcggg cgggcagatg cgccaaaagc caatggcgtg ccttatatta 2672041 aaggaaaaag ataaacattc tcccctggga agacgattct cagggatttt tttctaatcc 2672101 aaaagacccc cttaatttaa ttgtttatta gttttttaac ttaaaaaaat atgaagtgtt 2672161 aacgctttct tgtagactgt aacaaacaat acatgggggt gtatgacatg ggagcaattc 2672221 caaaaacggg gacaatttca cctgagcaaa aagactcaca ggagaaaaac ctgtttcaaa 2672281 aaatttggtc ttgggaaatc ggtgtgattc ctttgccatt atacacagta ttagctgtta 2672341 ttattattct tgcagcatat tacaatgagc tgccggcaaa tatgcttggc gggtttgcca 2672401 tcattatgat tcttggtgtg tttctcggag acataggcca acgcataccg atattgaagg 2672461 atattggcgg ccctgctatt ttatctttgt ttgttccttc atttttagtc ttttacaatg 2672521 tactgaattc aacatcttta gacgctgtaa ccaacttgat gaaaacgtct aacttccttt 2672581 atttctatat cgcttgcctt gttgtgggaa gtatcctcgg tatgaacaga attgttttaa 2672641 tacaggggtt tatcagaatg ttcgttccac tggttgcagg aacgatcgcg gccgttgcag 2672701 ccggcatcct tgtcggattt atttttggct atagtgccta tgattccttt ttctttgttg 2672761 ttgtcccgat tattgccggg ggaataggtg aagggatttt gccgctttca atcgcctatt 2672821 cacaaatact gggctcatcc gccgatgtat ttgtgtctca gctggtgcca gccgcaatta 2672881 taggaaacgt ttttgctatc atatgtgcag ccttaatgaa aaagcttggc gacaagcgtc 2672941 cagatctaaa tgggaacgga cgtctcgtaa aatctaaaaa agcaaatgag attttcaatc 2673001 aaaaagaagc cgaagcaaaa attgatttta aactaatggg agcaggagtt ctgctcgcgt 2673061 gtacattctt tatttttggc gggttattgg agaaattcat cttcatcccg ggcgcgatct 2673121 taatgattat ttcagctgcg gctgtcaagt atgcaaatat tcttccgaaa aaaatggaag 2673181 aaggcgctta ccagctttat aagtttattt cttcaagctt tacatggccg ctgatggtcg 2673241 gtctcggcat cctctttatt ccgttggatg acgtagcgtc tgtgatttct ataccgtttg 2673301 tcatcatctg tatttcagtt gttatcgcga tgattggttc tggatatttc gtaggcaagc 2673361 tgatgaacat gtatccggtt gaatccgcaa tcgttacctg ctgccacagc ggtctcggcg 2673421 gaacgggtga tgttgccatt ttatcggcat caggaagaat gggccttatg ccgtttgccc 2673481 aaatttcaac ccgtctcggc ggtgcaggca cagttatttg cgcgacagtg ctgcttcgtt 2673541 ttttcacttc ataaacagaa agagttccgt tttatgcgga actctttttt tatttattca 2673601 caatccgaat atactctcgg ggaccaaacg gcagatcctt tgattccgtc tcactcattc 2673661 tggctgacag gtggtgctcc agtaaataca gctcccactc atcacaagcc gccacaccgc 2673721 tgcgcccgtc atattgattc aacatgaatg cccctgcaaa tactgagcag aataaacctg 2673781 agcacatcac gacttttgtt ttcacatgac cagctccttt ccttcagctt gatcaggatt 2673841 gattttaaat atacaaataa cctctttttt gttagactta ttttgaggtc aaaagaactc 2673901 ataaaaatcc attacagcag ttcgaagcgt ggcagcttgc agaaaagtgc gatataattt 2673961 ggactaggtc gtttgaccgt atattttata catagcgcat ttttcaattg agaacgagaa 2674021 aaggaggtct tatctttgca gctcttacat cttgctattt tatcgccttt tttatttgct 2674081 tttatcattc ccttcttggc aaaatacgca aaaagagtgc atacgggctg gtttgtgttg 2674141 atcctgcccg tcttgctgtt tatatacttt ctcccaatga tcaggatgac gcaatctgga 2674201 gaaacacttc gatcggtatt agagtggatt ccgtcactcg gcattaactt taccgtttat 2674261 atagacggcc tcgggttatt attcgcttta ctgatcacag gcattggctc tttggtcact 2674321 ctttacagca ttttttattt atcgaaagaa aaagaacagc ttgggccctt ttatgtctac 2674381 ttattgatgt tcatgggcgc catgctcggc gtcgttctag tagacaatgt catggttctc 2674441 tacatgttct gggagcttac aagcctttca tcctttttgc tgatcggcta ttggtataag 2674501 cgggaaaagt cgcgctatgg cgcagccaaa tcacttttga ttacggtcag cggcgggctg 2674561 tgcatgctcg gcggatttat tctcctttat ttgataacgg attccttcag tattcgagag 2674621 atggttcacc aggttcaatt aattgccggc cacgaattgt ttatcccggc tatgattctc 2674681 attttattag gggcttttac gaaatcggcg caatttcctt tttacatctg gctccctgac 2674741 gcgatggaag ctccgacgcc tgtcagcgct tatctccatt cagctactat ggtaaaagcc 2674801 ggcatttatg tgattgcgag attcagtcct attttcgcct tttcagctca gtggttttgg 2674861 atcgtgtccc tcgtcggcct ctttacgatg gtttggggtt cattccatgc cgtgaaacaa 2674921 actgatttaa aatcgatttt ggcgttttca accgtcagcc agctcggcat gatcatctcc 2674981 atgctcggag tcagtgctgc ggcccttcat tacggacata cagaatatta tacagttgcc 2675041 gctatggctg ccattttcca tttgatcaac cacgcaacct ttaaaggaag cttgtttatg 2675101 gcagtcggga ttatcgatca cgaaacaggc acacgggata tccggaagct aggcggcctg 2675161 atggcgatta tgccgattac ttttaccatt tccttaatcg ggacattttc aatggccggc 2675221 ctaccgccgt ttaacggatt tttgagtaaa gaaatgtttt tcacaagcat gcttcgcgtg 2675281 acacattttg acctgttcaa cgtgcagaca tggggcgttc tgttccctct tttcgcctgg 2675341 atcggaagtg tatttacgtt tatctacagc atgaaattgc tgtttaaaac attcagagga 2675401 aattaccagc ctgaacagct tgaaaaacag gctcacgaag cgcctgtcgg tatgctcgtt 2675461 ccaccggtca ttcttgtcgc tttggctgtc agtctcttct ttttcccgaa tatattgtcg 2675521 tacagcctga tagagcctgc gatgaactca atctatccga cactgcttga cggccatgag 2675581 aaattccacg ttcacatttc acagtggcat ggggttacaa cggaattgct catgactgcg 2675641 ggtattgttg tgatcggaac aattggttat ttgtcgctga ataagtggaa aggaatctat 2675701 aaactgtttc cttcgaaact cacactcaac cggttatacg ataagctttt gactatgatg 2675761 gagaaaggct cttaccgggt cacaaaacaa tatatgaccg ggtttttaag agattatttg 2675821 ctgtatatct tcgctggttt catcattctg ataggcggag cttttgccat taaaggcgga 2675881 ttttcattta aaacggaagg catggctaaa atcggtgtat acgaaatcat tttgacgctt 2675941 gtcatgatca gcgccacagt ggcgactgtt tttgctaggt caagactgac ggcgatcatt 2676001 gcactcggtg ttgtcggtta tacgcttgca ttgttttttg tcattttcag agcgccggac 2676061 ttggcattga ctcagctcgt cattgaaacg atttctgtgg cactgtttct gctttgcttc 2676121 taccatttgc cgaaactgag gctgaaaaca aaaacgagaa cgttccggat gacgaatttt 2676181 atcatttctt taggcgtcgg tgttatcgtt acactgctcg gcatcgcatc ctcaagccag 2676241 cggacaaaag acagcattgc gtccttcttt gtcaaacaca gccacgatct cggcggaggg 2676301 gataatgtcg tcaatgtcat tctcgttgat ttcaggggat ttgatacaat gtttgaaatt 2676361 acggtattaa cgatagccgc tctcggcatt tacagcatga ttaaaacaaa agtaaaagag 2676421 gaggggaaaa gcggtgaatg aacaaaaaac aaatgacttg attcttcaaa ccgcgacaaa 2676481 gcttgtatcc tttatcattt tgcttttctc tttctattta tttttatcag ggcataacgc 2676541 gcccggagga ggctttgtcg gcggactgat cacgtcctct tccatcgttc tcttgctctt 2676601 ggcatatgat ttaaaaaccg tgcgttccct tttgcctgtc aatttcattt atgtcgcggg 2676661 agccggcctt ctgctcgctg tattaacagg cgttggctcc tttgtcttcg gggctccttt 2676721 tttaacccac acattcggat actttcagct gccgatcctt gggaaaacgg agctcgccac 2676781 agcgacgata tttgatttag gcgtttatct tgttgtcgta ggcataacga tgaccattat 2676841 tcaaacgatt ggagaggaag aataatggaa atcttaatgg ctgtattagc cggtattatt 2676901 tttatggctg ctacgtattt gctgctgtct aaaagcctgc ttcgcgtcat tatcggaaca 2676961 gcactgttaa gccatggcgt tcatttaatg cttttgacta tgggaggatt aaagaaaggc 2677021 gccgctccga ttttgagcga gcatgccaaa tcatttgtcg atccgcttcc gcaagccctg 2677081 attttgaccg caattgtcat ttcttttggc gttacgtcat tcatcctcgt catggccttt 2677141 cgcgcttatc aggaattgaa atcggacgat atggatcaaa tgaggggaaa tgatcaacat 2677201 gaataatttt gttattttgc caatcctgat cccgcttttg tcggctattc ttctgatttt 2677261 catgacgaag aatcttatgc tcatgagaat cttcagcacg gcggcatcgg ccatcgggat 2677321 tgtgattagc ggcatacttg tacagactgt cttcacaaaa ggcatccaga cactcagcct 2677381 aggcggatgg aaagcgccgt acggcattgt gcttgccgca gaccaattcg ccagccttct 2677441 cgttctcaca acagcgatca tcggtttatt ggttgggctt tattccttcc gttctgtcgg 2677501 tgaaaaacgg gagcgctcct tttactactc cggcgttcag ttcttgcttg ccggcgtcag 2677561 cggagcgttt ttaacaggcg atttatttaa tatgtacgta ttttttgagc ttctgcttat 2677621 tgcttcctat atgctgattg tattaggcgg cacaaaaatt cagctgcggg aatcccttaa 2677681 atatattgtg tttaatattg tatcgtctgc cctgtttgtc ataggggtcg gctttttata 2677741 cgctgtaacc ggtacgttaa acatggcgga tcttagcgtg aaaatcagcg aatcaggaca 2677801 aaccgggctg atcactgtga ttggtgtcct gctgcttttg gtatttggca tgaagggcgg 2677861 aatcttcccc ctctactttt ggcttccagg ctcttattac gcgccaccgg cggcaatctc 2677921 cgcgttgttc ggcgctttgc tgacaaaagt cgggttatat gcgattacga gggttttcac 2677981 attgattttt attcacgata cagcctttac ccatcagttg atgatttggc tggcggcgct 2678041 gactgtgatt tttggtgtga tcggttcact cgcttattcg aatgtcatga aaattgtgat 2678101 ctataacatt attaccgctg tcggcgtgat tttgttcggt gtggcagtac acacccccgc 2678161 atccattcag ggcgcgatct actatctgat tcacgatatg ctgattaagg gcgctttgtt 2678221 catgctggca ggtacgctga tcgcattgac tggaaccgcg agcctgcata aaatgggcgg 2678281 gctgatcaaa cgctatcctg ttcttggatg gatgtttttc atttccgcta tttctcttgc 2678341 aggcattccg ccactgagcg gatttgtcgg caaatttaaa attgcagagg gcggcttcgc 2678401 agaaggtgaa tttacgatat ccatgctgat tctgctttcg agtctgcttg tactgtactc 2678461 tgtgctgagg atctttatac atgcgttttg gggcgaagaa aaagaaacgc caaaaccaaa 2678521 tcatcgaaca gctaaaggac ttctttatcc ggcagctatt tttctcttgc tgtcccttct 2678581 cttcggattg ggtacagaat gggtgtcgcc ttacgttgat caagcggccg agacgctgct 2678641 gaatccggaa aaatatatcg aagctgttct gaaggagtag atcgcatggc atttcaaatt 2678701 ttattaaatg tgtttctcgc tttttgctgg atgttcttaa gcaacagtcc aagcgccgca 2678761 ggattcatta caggctatat tctgggaatg ctctctctct ttttcttccg gcgctttttc 2678821 actcgccagt tttatctatg gaaattgatt tctattatca agctctgttt catttttata 2678881 aaggaactgt accttgccaa tgtcagtgtg atgaaatcag tcttatctcc aaaactgaat 2678941 atcagaccgg gtatttttgc ttttaaaact gaactgacga aggactggga aatcaccatg 2679001 ctttctctgc tcattacatt aacgccggga accttggtga tggatatttc agatgacaga 2679061 acaatacttt atattcatgc aatggatatc gaggatgcgg aaaaagcgat ttttgacatt 2679121 cgggagtcat ttgaaaaagc catacaggag gtgagccggt gatgtttacg ctgatcctgc 2679181 aaatcgcgct cggcattatg gcagtgtcta cctttttgta tgtcattcgt gtcattaaag 2679241 gtccgactgt gcctgaccgg gtcgtggctc tggatgcaat cggcatcaat ctgatcgcaa 2679301 tcacggcgct tgtctccatt ttgctgaaaa caagtgcgtt tttggatatt attttgttgc 2679361 tggggatttt atcgtttatc ggaacgatcg cattttccaa gttcctggag aaaggagaga 2679421 ttatcgaaaa tgatcgaaac cgctaaggtc gttgtggctg tattcatttt gctgggtgct 2679481 cttatatgcc tcattgcttc atttggcgta cttcgccttc ccgatgtgtt tacacgcgct 2679541 catgctgctt ctaaaggctc aacattaggt gtcaatatga ttctgctcgg tgtcttcttc 2679601 tatttgtggt ttgtgacggg ggagctctcc gctaaaatcc tgcttgggat tctctttatc 2679661 tttattacgt cgcctatcgg cgggcacttg atctgccgtg ctgcgtataa ctccggcgtc 2679721 aagcttgatg agagaagtgt gcaagatgac tataacggaa tcagaaactt tgtgattaaa 2679781 cgaaaagagg attcttattt ataaaaataa gcagccggac aggcagagtt ccggctgttt 2679841 ttttatttct tgatgacagc cagcgtgcat ctggatatac agatcagcct ctcttgctcg 2679901 tcatatatgt gaatatgata gacaatcgtc gttctgccta tatgaacggg ctcggctatc 2679961 gcctttaccg ttccttcctt tacagatttt aaatggttgg cgttaatctc caaaccaaca 2680021 caagcttgcg ttgtatgatc aatcaggttc tgtgcacctg cgctcgccgc ggtttccgcc 2680081 agggccactg aagcgcctcc atgcaaatat ccgaacggct gtaccgtccg atgatccacc 2680141 ggcatgaccg caacgcatcg ttccgctgtg ttttcaacaa tctcaatacc aagcgcttca 2680201 agcaatgtgt gcttcatatc catctctaca ccccccaaca tttaaagtac accgtctgat 2680261 ttcgcaatca aaaccgcttc cgtccgtgaa ccgacattca gcttattgaa aatcgatgtc 2680321 aagctgtatt caatggaccg cttgcttaaa tgaagggcat ctgcgatttc ttggtttgta 2680381 aatccctttt caacttcttg aagaatcagg cattctctag gtgtgagcac atcttgttct 2680441 ttttgagagg aaggagccgg ctttgttttt tgctgagtca tcagctgttt aaagtaagca 2680501 aaatcgacta aaatttctcc gttgagtacg tggtatatgt attgggtgat cttttcttta 2680561 gattccgttt tgctgatggc accgtgcaga cccgcacgaa tcgcttcctc gaaataatcc 2680621 tcgacctcat aaccggtata cacgataatt ttacaatgag gattctcttg taaaatctgt 2680681 ttagaaagct ccatcccatt gacctcgccg cctagattca gatccattaa aatgagatca 2680741 tatgacgaga aatcatgctg cttgataaac tgttcgctcg gttcaggact gagacaatca 2680801 acagacaaat tcgaatccgt ttccaaaatt gtcttggtgc cttccatgac agccggatgg 2680861 tcatcaatca ctagtatctt tttcatgttt tcctcccttt tactcactct tttccatttt 2680921 ataaaaaaga cttggcctgt gccaagtcgt ttccgttata aatccattac aattcgattt 2680981 caatatcagc cttaaagccc tttccttcac ttgtttcaat ccgaaggcgc ccatctaaag 2681041 ccctgactct ctccttaatg ccagaaagcc ccatgctcat ggaatgctca gtattttttt 2681101 cttgatcaaa cccaacgcca tcgtcctcat aatgaagaac gattttgttt tgaatactga 2681161 tgagcataat cagcacatcc gtcgcctgag agtgcttgac cgcattagac agaaactctt 2681221 gaatgatccg gtacaaattc agctgcgaat ccagatcaag ggaagccgta aatctcccgg 2681281 tatttaaacg gatatgaaac ggaacccgct cctgctgctg cgccaccagc ttcgacagcg 2681341 ccttcaccaa tccaagatca tacagaagct gcggccgcag ctcatgacac gtctccctcg 2681401 tcatcgaaat cacatcagac atctgctcat tcatctgtac aagcttgtcc tgcacctctt 2681461 cacggcacgg attatcatcc ttcttgaaat cacccaaaaa cagctcacac tggcgtttta 2681521 aggaaatcaa atcctgaaga accgaatcgt ggagatcgcg ggcgagtcct gaacgctgtt 2681581 tttcttcgat tgcaaacatt agctttttca gccagatggg gttggttccc tcttgtttta 2681641 agtccttcaa atgttccatg agctcctcaa tatgcaggac attttccatg gacacacttg 2681701 tataaaaaga cagtgttttc agccacgata tttcatcacg tgttagccgg ggagtgttaa 2681761 tattagataa acaaagcaga acataagaac taccgcctcg ttcaccaact ttcataagaa 2681821 agccttgatt gacttctata attttcccaa tttctgaagt tacgttttca aattcctctt 2681881 gataaaaatt ccagtccggt ccaacttcat gcttatctaa aaatatcact ttgtgatcag 2681941 gagtaacctc aaaggtataa gctttgctta caagcaaaac atccagtata gtatttttca 2682001 gttctttaaa aacttgttga agagaagtta cacccctcat tagctgagta tatttaaaaa 2682061 tactgtcctg atagttgaat ttttcggaga aacgttttaa ccgaaattta aaatccatga 2682121 cctctttaaa ataaaagaca gcgaacatga caacgaaaaa aaatacagtt tgacgcacag 2682181 ggttcatctg gatgtccatt acatcaaaca gaactaatgc accaactatt agaagagttg 2682241 gtatcatggc aagtagagca tagtatctca ttcttcctaa gataaactct atatcaaaca 2682301 tcttattggc tacaaattgg tatactaacc cgaacggaat tagtactagt aatgacgccg 2682361 aagctaatgc cgggaaaata taattacctg taaatattat tggaagaaca aaaaatatca 2682421 aaaaaggcgc aaatgaaaga gtgtttgtta aaattagtaa tttaagaata aacgaatgct 2682481 cagcatattt atatttatta agatgtaagt atatcgctga aaaagaaaat agagtcaaag 2682541 ttgcaaaaga aaccaaatta agagttgcta aaaaatcaat atctacttgt aaatagtctt 2682601 gaaaaaactc aataccaaga ttaaatattg gtatgatata aagaaaagaa attctattca 2682661 aaaaagtttt acctatttct ccaaggtatc tttgtataaa ttgaagataa agaataggag 2682721 aagatataaa agtaaacaag ttaatatacc gattgattat atgtcctcta aatggtccgc 2682781 ctgcacttat atatgctatc gaaatgtcta ataacaatag aataagaata taggcagcaa 2682841 atgatctcct ttttttattt actttaagta tataaaaaat acatattatg cttaaaaaat 2682901 aaaaaaacaa aggaagtacg aacagaaaaa aactataagg tctatttaga gtaactaaat 2682961 caaaatcttt gagatgaatc ttttttccac ttctcaaaat atccagactg ttaatatgac 2683021 tcaaatatcc ccatttcaaa tgtttgtctg aaggtttttc tttattaatt tttaatatga 2683081 tgtctccctg tctcagacca acaaattgtc catatgaaga ttccgatatt tcttctatca 2683141 taaattgact tttatcattt ttatgaatct tagtcccaat aataattcca ttcatactga 2683201 tataagttgt atagcttata taaaggatac tcaaaacaat tacagctatt gtgaattttt 2683261 ttattaagtt cttcaatatt aatccaccta ttaatcaccc cattgacggg ttattggatc 2683321 agccagataa taatcattat aagctttaat tattgtttca gtttcttgca catcaaaacc 2683381 tataaggcag gcttctttat ttttcaattt ttttaaagcc tcaggataat ttaaaaagta 2683441 gttaattagg tcttgcatct tgtatccccc tttgtataac ttaataagca ttcctttatt 2683501 agctcttttt ttctttatct aaatttaatt gttctatagc agaaatacat ttctgtttat 2683561 atatttccaa taataccgaa atgtattgag taactcccgc tttaattaat ttttcttgga 2683621 atttctcttt atcaagtaac gatttataat ataagtcttt atgtgaaatt aagtataata 2683681 aatcttccga agcatcatta aaaaggcgct taagatataa gtaaatcagt gtatgtttgt 2683741 ttttttcaat atcactgcga tttccggata aaagaacata ataatctcca gaaatttgag 2683801 ctataatccc tttatagtag gaatatcttt caactgtttc attatattct cctgtagcca 2683861 ataaaacacc tgctacattt gctagtgcaa tcagacttcc acattttaat ctaattactt 2683921 ctaaactttc atcttctgtt ttagatttat tagtgatatc gtcatgttga ccttgcatgg 2683981 cctcgtttac gtattttaaa acatatttaa aaattagagg attgttattt aatgaataaa 2684041 tactcgttaa tcctactgta tacaaggaaa gtgctgcatt taacgactcc gagcgattaa 2684101 ttttcatcca taatgcatgg tgattatctt catcttcaag atcatccata atatctgatg 2684161 aaagaataag aatttctatt cccgcgccaa gccttgttgc aacatctaaa ttctcccctc 2684221 caaaaacaac ataatgtaag attgtggatt cagcaaagga gaatgtttct ttagaatcaa 2684281 taaatgagta aagaagttgt gacaaatcct cgttaaatat gttttgctcc acaatctcct 2684341 tcattttctc cttgatccgg acagaatcta aacatatctg ctcaataacg acttcccccc 2684401 tcccattcca ttttactaaa tgggacattt aaaggacagc aggtttttcg ttttttaaca 2684461 atcatataat actttatcca tttattgtat cggtagaacg aaaaaaaaga cttgtttcca 2684521 agtctttttc acgaaatttt cattgcataa ttgtatttat cgagttgatc aatgcttttg 2684581 ttaatgtttc gtaatgaatc tgtcgtttct ttaatatcaa gttcgagtcg gaataacaat 2684641 tgttttactt cttcaagttt cttttccatc gtttccacac tccttttttt gaaagatcaa 2684701 tgaattgtgt atggtgaacg agtcctaggt atttgatctg ttactaatag tgtgtctgct 2684761 ttcggctcat ttttcaccga aaagtatgca aaaaagtcct gcgtgacacc gcaaatctca 2684821 ataggtcctt atactcaaag gaatcacaac aagaacggga ctatctttct atgcgaaaga 2684881 gcgtttatat gtgctgaaat tgagaaagat tcttaatctc cttgatttta acgggtttcg 2684941 cattttcact aagcaagact atagtccttc ataccgtatt ttcaaaattg aatatgcgat 2685001 tcttggcgtt tcctgaccga caaacaccga aaaagaccgc aacgctaaag ttgtggcctt 2685061 ttcgctttgt catattcggc aattagggat ctatacatat agaaacatcc ttttttgcga 2685121 ggtgctccca tgagatatcg ttatccctgg ttttacgtgt atccgtatga ggtacgccgt 2685181 ccgcccgctc ctgccaacaa tattgatacc tttatccgtt cagcgaagca ggccgcaggg 2685241 atatttgcgg atgcccagct cgttctcagc cgcattgcgg gctcgcggga gctttcgcgc 2685301 cgcattctga ccgcagccga acagtctgat aaacaaacta taaggcgcct gatcaaacaa 2685361 atgggcgtcc ggcatgaagt ggatacggtc tttaatcccg acggcatcta tatcagcctt 2685421 atcggaacgc aaagccgaat gattcttgct ttgcggtggt cagaggaccg caatcatttt 2685481 gcgtccataa gattatgaca ccattccaga gcctctaaat aacattcata cgcttcttct 2685541 ttgtccagtt gattgcctaa ttctgagcaa gtgtcccagt tgttgctttc aattaatttc 2685601 acaagctcaa gcatttggta gtagtcgttt tgatggccta ataatgcttg cccgacttca 2685661 tcttttaaag gcaattcttg aacaatttcc tctatttctc tatgcaggag ggtgtctatg 2685721 agagaaaaca ttccgatcag catataagaa gcaggctgcg gccgggatgt ctttctcgcc 2685781 agcagttcgc aaagctttgc tcttatcaga gaaatcttaa tgatttcgtg cttgctggaa 2685841 tgccctttcc tgcttaaatc cttaaaggaa agaatatata tccaccgttt gatttcatta 2685901 aatcccagca gcataatggc ctgttgaatg ctttcaattt tctggctcaa acggctgtgg 2685961 gatgagttta aaaattttaa aatttgatag gacagtgata aatcccgctc tatgtactct 2686021 gtcacacgct ttatgttagg ctgctcttta ctcagttcgt taagcagttc atagtaagaa 2686081 tagaaatgag tcgataggtc atgcccgctg atgatgcgcg gctcgctgaa aaagtagcct 2686141 tggaataatt gaaagccgtc ttggaccgcc tgtttatatt cttttcgggt ctctactttt 2686201 tccgctaaaa aaatcaggcc gcggcagccg taggtttgca aaattgttct gcgttccatt 2686261 cgtgttgttt tgagaaaatc aattttcaat atatcaatat agctcatgag tttttccagt 2686321 aagtcctcat cttgcggatt tattgcataa aaatcatcaa gcgccagcat ataccccatt 2686381 tttttcaatt ctttgcatct agaaatgagg gccggcgtga tcggtatatc ttcaaggatt 2686441 tcaatgacaa gctgtttcgg attgaaggag gtgggaagat tcgaaaacat caggctttcc 2686501 gtaaaattaa caaaacagcg tttcccttcc gtcagcttct caattccgat gtttaaaaag 2686561 ctgttgatca ccaaatctgt tgttgcctga tcgccgtctt tagcgctata cacgttctct 2686621 tcgctttctc tatacagcag ttcataagca acaacctgtt cttttctatt aaaaataggc 2686681 tgtcttgcaa caaacaccct cattgattta tcccccttac aatacgcgcg gctttcaccc 2686741 ctaagtatat caaataattt gacgaaaatt gtctaaacat gaaaaataat atatacataa 2686801 agaaaactgg cccttcgcga atgaaaggcc agtttttctt tattcttcct caagctcttc 2686861 ttcaattctg cttttcactt cgtggatccg ctgcatttta ttgctccagc agtcctcgct 2686921 taaatcaacc gggtattcct ccggcttgct gattctctta tattcctccc aaagcaggct 2686981 gaggttatcc tgcacatact gctgtatgtc tgaaatctca gggttttggt agcaaagaat 2687041 acccttctca aaaatcagtt catgaagatc cttcgcataa aaattcgtga caaatttgct 2687101 gatgaatgta tgaaccgggt ggaacattct gagccgcttc tgatcattca cctgctcatc 2687161 ataaagcgca atatagtcgc cttcagaatg atggttggac tgattaataa tgcggtagac 2687221 tttctttctg cccggtgtcg tcactttttc aggattggac gaaattttga tcgtgtcgac 2687281 cattttcccg tcttcttcaa tggcaacgag tttataaact gcgccgagag ccggctggtc 2687341 ataggcagtg atcagcttcg taccgacacc ccagacatca atgcgcgctc cctgagcctt 2687401 taaattcata atggtgtgct catccaaatc gcttgaagca atcaccttcg catctgtaaa 2687461 tcctgcttca tcaagcattt tccgggcttt ttttgacagg tacgccaaat cgccgctgtc 2687521 cagacggatg ccaatgaaat taatgcggtc gccgaattcc ttggcaaccc taatcgcgtt 2687581 cggcatgcct gaacgaagcg tgtcatacgt gtcaactaag aagacgcaat ccttatgtgt 2687641 ttccgcgtat tttttgaaag ctgtatattc atcgcggtaa gcctgcacaa gcgcatgcgc 2687701 atgtgtgccg gaaaccggga tattaaagcg ctttccggct cttacattgc ttgtcgcgct 2687761 aaagccgccg attaaggctg ctctcgctcc ccacatggcc gcatccattt cgtgcgcccg 2687821 tcttgttccg aattcaagcg caacttcatc accgatgacg cctttaatcc gggcagcctt 2687881 tgttgcgatt aatgtttgat agttcacaat gttgagcaaa gctgtttcaa tcagctgcgc 2687941 ttctaccagg ggtgcctcca ccctcataat cggctcattg ttaaaaacga gttctccttc 2688001 tttcatggag taaagtgaac ctgtaaaaga taagccgcgc aaatattcaa taaaatcttc 2688061 atgatacccg agttcatcct gtaaataact caaatcgcta tccgtaaact tgaaattttc 2688121 caagtattca atggcttttt ccaagcccgc aaatacggca tagccatttt caaacggaag 2688181 ccttctgaaa aacagctcaa aaatcgcttt cttttcatga atgccgtctc tccagtacgt 2688241 ttccgccata ttgatctgat aaaggtctgt atgtaatgac aggctgtcat ctttaaatcc 2688301 gtactctaac actgtttttc cccttcctta ctctgccact tgcgctccga tgctgtttgc 2688361 aaaatgggaa agagcccatg cgtgcccctc ctgattaaag ctggcaacag cttgtttatg 2688421 cacaacaatc cgaaaacctt tgttgtatgc gtcaacagct gtatgcaaca cacaaatatc 2688481 tgtgcagaca ccggcaagat gcagttcgcc aatctgccgc tctctgagtt tgagctctaa 2688541 atcagttccc gcaaaagcag aatatctcgt tttttccatg tagtaaacat taggttcatg 2688601 ttcatgtttc tgatatagag gcaaaagctt tccgtacaga tcttttcctt ccgtgccttt 2688661 tatattatgc ggaggaaaaa gacgggtttc agggtgatat tgatcccctt catcatgaga 2688721 atctactgct aatacgacgt aatcaccgtt tgtgatgaat tctttagtta aattgacgat 2688781 cgcctcttca atcattctgc cgggctcccc gcaggtcaat tttccgtcac tcgccacaaa 2688841 atcattcgta taatcaatac aaataagtgc ttttttcata gccggcctcc ccgccatcag 2688901 tatgagaaca ttatatctta tctccagttg taagtgaatt gccatgaaca aaaagacaaa 2688961 cggtccgttt gtctcttacg atttcagtac tgaccgatta taaatgtcgt cctgaatata 2689021 tatcaattca cgattcacag cgatatcagc cgcaatgacg atgcctaagg gcgtatgaaa 2689081 ctggagatca gatacaatct tgaaaggcac tccgtaccgg ctcgccattt ggatataaga 2689141 agagtaagac tgatactgaa gctctccatt aatcaaaagg gtgacgttat ggctgttttt 2689201 cagctcgtgc tctgcctctt tatacggttt gcttctaagc acctgtcctt tcgtcagtgc 2689261 caaaacgact ctttctctta aagagcctaa aaacaaatgg cgctcgtcag gctttgtctc 2689321 caaaggccca tacattcctt gctgcaaata gagatccatt ttatcttcac tcaaaagcct 2689381 gtcctcccgt cttgtttgtc ttcattatca cctgatcagg caggagctaa actttcaagc 2689441 gccgtttaca tttctgttac ccaatgaatg atttttttgg ccagctcacc agcaggggtt 2689501 tcctctgtat gccggcgcaa cgacgcttcc agccgttcag gcagagttgc tttatcttct 2689561 tcataggaaa tgatcgtgct ccactccagc tgcggtaccg ctacaagcgt gcgcagttct 2689621 tttctgtttt catgcagata cacgtccgtg atcattccgg tttgcgtatt gatatttgct 2689681 tttctgattt tcataacatg acctctctat tcaaagacta cccatattat acaataaaaa 2689741 agcaacagcc tcttgtgaaa aggctgttac ccgttaaacg aaactgtttc atcagtgata 2689801 tcggcatctt tgaagagagt tttactcgtt tggttgttaa tcttcacaaa atcaccaagc 2689861 tgaaatgtgc ctgaccccgc ccctgaatga gcgacgcttt tgggcgaaat cgcaaatacg 2689921 tctccaaagc ttgccgcggc attatccgta actgacatga tataaatcgg ccccacaatt 2689981 gcaggcattt ccccacctcc gcattgattt acagcatcat atgcaaggag ccgataatgg 2690041 tgcccgccta ttcagctggc tttgcgtttt cctcgagtcg tgaccgctgg cgcagcttga 2690101 tcaagcggac aatattcagg aagaacgcct tcactaccgc ataaaccggc accgctaaaa 2690161 tcatgccgag aattccgccg aagcttcccg ctccgattaa tagcaaaata atcgtaagcg 2690221 gatgggtatt cagccgcttt ccgatcacaa gaggagacag caggtttccg tccagctgct 2690281 gaacgatgac gaccacaata atcgcaaaca gcgctttggc cggcgagtcc ataaaaccga 2690341 caatgacagc cggcgcggca ccgagaaaag gcccgacata gggaatgata ttggtaatcg 2690401 ccatgacaat cccaagaatc agggcatacg gcagtccggc aattaaatag ccgataaaac 2690461 acgctgttcc gacaaaaaga cagattaaca gctgcccctg gaaatatgcc gcaagcgtat 2690521 cggataaatc tttaaaaatc tttaagcctt ctgtccgata agaagccggt agaattttta 2690581 ctgccaaatg cggaaagcgg tgtccgtctt tcagcatgta aaaaaggata aatggaacag 2690641 taataataac aagcgtgatg tttgtcacga caccaaacac cgcagataaa ctggacgtga 2690701 tattttgcgg caggttttgg agaaaacttg tcaatgactg ttcaattttt gatatcgata 2690761 cataatcctg gttcatcatc caggtaaacc attgagaatg ggacaaatcc tttgtcagcg 2690821 cctgaatctg ttttatataa tcaggaaggt tgttaaacag ccctgtcacc tgtgcggtga 2690881 tgataggtcc gactgacgct gaaataaagg caagcaaacc gataaacagt aaatagatca 2690941 atagaatgga taatgtccgc ggaatttttt tctcaagcag gcggacgacc ggattaaata 2691001 tgaaatacaa aattcccgca attagcatcg ggaaaaacaa tgtcgagata aaaacaataa 2691061 acggctgaaa tacaaatgaa acttttgttg ctacaaaaat aatcagcaaa acaaataaaa 2691121 tctgcaatgt ccaaaaatgg acttttgatt tcaacaagct ttgttcctcc tagtttttct 2691181 ttgtctgtca gataaaagaa cttatacccc atcattgtaa caaaaatgaa ctcatatcag 2691241 aactcttaat ataatgaaag gagtgttggt gatgaaggcc gtgacatacg atacagattc 2691301 agaactggct tatatctatg ttcttcctcc gaaaaagaac aggaatgtac ggactgagga 2691361 gctcagagtc aatgattgtc tcctgctgga tatcagccaa gatggcaaaa tcgccggatt 2691421 cgaatgtttt ggtgaggcag cacacctctg tgccccattt gccgggaaat cccggctgta 2691481 tgtaaaagat tcagacggtt atcattttcg ggtctgccag catgcttcag tccgttcctg 2691541 ctatacggtg taccgtgtca ctttctgttt ttcagatggt gactatcagg aatttgccgg 2691601 ctttgacctt gatggaacaa tgtatcatag tgcgttttta cagcgcttaa ctgaaaaata 2691661 ggacgtcctg ttgtacgcct atttttcatg cgcaagcact gttagacccg ctcactgtaa 2691721 tctggggtga cggaaatcat gtgctggatt ctgatcaaac aaacagaatt tcgggctcct 2691781 tcaattgtga tatggtcagg ttttacatcg atcagtctgc ctctgaccgt atctcgtact 2691841 gtctgtataa cgaaccttga gccgatgagc tttttaatgg tctgatagac ataaggatcg 2691901 actaaagaga ccagttgcgg actaccttgg ttgaccatac ttttatcccc tttgtgtgtt 2691961 ttatctcagc ttatgccgcg cttatggata atgacacagg cttacctgat aaaacaaagg 2692021 ggtgcggaga ttttaggaga atacgtttgg aggcgggtgt aaaggaagta tcgatgaagc 2692081 ggagacagcg aagaaagctg gcgctgttcc gtacttatac aggctttatc acggatgcct 2692141 gggcttggtc gattaattgg tccagctttt ctattttttt tcgtgcggtt gaaggatcaa 2692201 tttggcggta atgatggtgg ccgcccggct cttcatccag ttcgtccgct tttttgacaa 2692261 tctgctgcag tgtgttttta tctaattcgc cttcaggcaa ataggaatct gtatgaagca 2692321 aaatggctag tgcaatctct tttgctgctt tcggttcctc gccaagccga atcagaagtt 2692381 tatgcgcccg ttccgcccct ttaatggcat gaatgtcatt tcttttgtat ttctcataat 2692441 cccactttcc gtctgtatac cattcataat ggccaatgtc atgaagcagt gccgcttttg 2692501 ctgctaaatc aggattaatg tcagccttca cagacagcct gtatgcatga taagcgcagg 2692561 caatcgcatg tgccacgccg gaacgctgaa gatatttttg tgcaattgga tgggtgaaaa 2692621 catccattaa tgtaaccttt ctcatggaaa cccctccttt agatattttt agaatcctaa 2692681 cataatttgc agagaaactc aattcttatg tcacatcatt ttgatcttct tatcatcatt 2692741 gttataccct aaaagcaacg tttcagtcag tatatgcggc tgttcaataa aatgcgctgg 2692801 ctgcagcctt ttgtataaaa aaaagagcag aaaatatctg ctctacaaaa actctttaat 2692861 atcataaatg cggccgtttt ccgtcccttt ttctagtaaa gaaagcagcg tgccggcaat 2692921 aaagtccgga ctgcgaaggc ttcctgtttc atttaatttc cggaatcgtt caatgtggtg 2692981 gaaatccttt ttcgatgaag aacggatgac ggcctgcatc tcagtgtcca tcactccagg 2693041 tgagaacgaa atcatgttca ccggcagctc ttcatcctcc tgttcaaatc cgaatgtcct 2693101 cgtaaacatg tcgagcccgg cttttgaact gcaatacgcg ctccatccct tatatggatt 2693161 tttggcggct cctgaagtaa tgttgacaac cgtctttttg ccgctgtatg aagcaaaccg 2693221 ttttgtaaac agctgactca aaagcacggg cgcagtcagg ttcagctgat aatggcgctg 2693281 aagctcgtca agagacgctt cgccggcacg tttgatcggc gttaccattc cggcgttatt 2693341 aataagggta ataccagaat aacgatctga atcgatggat gagagcaatg tttcaaattg 2693401 ctgttcagct tcttcgagat tgatgaggtc tatttgatgc tgcgttagtt ttttgtgaga 2693461 gacatctgtt ttcgttctgg ataaggcatg gacttcatgc cccttttcta aagcctgtaa 2693521 tgcaatggct tgacccagcc cttttgacgc tccggtgatg atataaagtt ccattggaaa 2693581 cctccttttc cgttattatt gtacggcacc tcttttacac aacacaagca cgcggcctac 2693641 gccttcttgt tttcctgcgc tgtgactttt gggatgagga acacgatgcc tgcaattccg 2693701 agcaggatca gtacgacata gatcatcggc agcagcaatg atgatgtttc ttgttcatct 2693761 tctgtttccg ttgatgatgt ctttgtcatt ggtttttcag caaaagtaat tccaagctgt 2693821 ttcgactggg ccgcaatcgt gttggaatcc tcggcatttg ttgatgtaaa caaatctttt 2693881 atcagctcgg cgtccttgtc cttcggttta tcaaaagtga tatccttttg ttcctcaggc 2693941 agttctgttt tttcttcata gtaggtatct tcatgcaaat aattcgtatc gatttcgatg 2694001 tcttttttct catactggtt tggcgcgaca tctgtatttt cttcagtttg ggcagccgct 2694061 gcagagggta tgaaaaggga aaaggagagc atacaaatca tgatcccctt ttccatgctg 2694121 cgatcacgct tcatacgttt catcgctttc tgctgtgtgt tcagccatca accggataat 2694181 cagcggcaga gccacggcaa tcaccgtaat gatcagcaga actgttattc ccattgtaaa 2694241 caagtgccca gtaccgtact ggatgtcgat atatactttc gaaaccggat cttcaaatgt 2694301 aaagttcggc atgatcaaat caataagcgg tgcgacatag aataggatca ttgctgctga 2694361 agcaacccag ccagggattg atccgaatct gaatgccgtc cggatgaagg cagagcttgc 2694421 gaccagcaat agaatcgtaa acaccgacca cttaatcgtc tgatcgtccg gcagtgaata 2694481 aatattcaag ccgaacaagc tgatcataag tccgacaagg atattcagaa ttccgaataa 2694541 cgctcctttg acgagaagcg gtgcgttttg gtaatacgag ctgaaatagc cgattaacag 2694601 actgctgatc aacacaatga caaggatgac aaccggaggt accgtctgaa ttttttcttc 2694661 cggaacctct ccgctgattt taagcggatt cgctaagtaa tcatatacat agccattgtt 2694721 ttgcccgtct actaatgtat ttccgagtat gccgtatacg tcatttcgca cgagtttcgt 2694781 ggaggcgaca tttttccccc agttgttgtt taaggtgtcg gctttcgctt gaacatcatt 2694841 aacgctttgc tgcatgttgg ttgtgtaatc aatgatgccg gactggcgat cagacaatga 2694901 acccatcatg tctgacattt gcagcacttc ctggccgacc gtatcttgga cactcagtgc 2694961 catggtacca gacagcccat cgttgctgaa cgtcgcagat tcctgtgttg cgcccgttac 2695021 aagctgttct gacgcttttg cggcactttc agagattttc gtcagttcgt cgagaacacc 2695081 tgcttgagag tcacggatat agccgctgta gtcgtccgca aatttggtca tgccgtcgat 2695141 gaagctgtta atatcctcat ctgtttgcat cgtgttgttt ttgagagctt cccagctggc 2695201 tgattcttca ggtgtgagag ccaggactga ttggacgttg ccatcttgct cttggatgac 2695261 ttcaccttta ataatagtca aagagcctag atccagatta tcatttagcg tagacttata 2695321 taaatttaaa gagttgtaat acttcatcaa gttagaaata ttatcagttt caattctact 2695381 tgaaaaaatt gaacttagtt tttctttctg atctatatag cctctactct gcaaagtttg 2695441 tattatttcg tcttccaaat tgtatattaa cctataagca tcattgacat tattatcaaa 2695501 atcaaccaac ttttttgtta agtcaccaat ttgatcattt aattttgaaa ctgttttatt 2695561 taactcttta atttcttgat ttaactcatc aatatgtttc tctagtttgt tgttatgttc 2695621 ctcttgtttt tcttgaagtg cattttctat ttcctctaat tttatcgctg cttcgttcag 2695681 acgttttttt gcacctgaaa tatcagtttc accgtcagct ccgtcaccct gtagcccatc 2695741 actttgattt gagccatcgt tttcatctgc gagttcaatc aaagagaaat ctgttttaga 2695801 ggttcctgta ttctccgtgt ttgtatcttg ttcaggaacg ttttttgaag attcttgatg 2695861 tttttgtccc gtttcaatgt tagtttgaac atcattttgt gatccattat cttgagtacc 2695921 ctcttctgat gagccagtat cttcatttgt tggctgatca tcggatgttg gaatatcatt 2695981 cgacggttct tcagtattag gagaatcatc ggttgatggt tcttcagcat cgggtgttgt 2696041 tggtttttct tgttcaggtt cttttaaccc ttcagagata tctttaattt cagttgcaac 2696101 atttttgagc tcatcccgct gcttctctaa atccaatttt atatcttcaa tatcttcctt 2696161 atctgtgtca tctttattat cagatgtgtc ttctccatct tccttttcgt cgctttcctt 2696221 aggtttaagt aaactaaggc ggttcttccc gatattctct tgcaattgat ttaaattttg 2696281 atatttaata gcttcatatt gacttttata tcgagataga aatgcattaa acatgtcatt 2696341 ctcaattttt ttcataccca tttcttgcaa tggcacttga ttttgcctta acttttcagc 2696401 attgttcaac gcaaggtttg tcagtcctat ttgtgtcttc gcttggccga tcccggttgc 2696461 caatccgctc atgcgttcgc tgaactgatt cgccttttgc tgtgcctgga tggcatccag 2696521 acctgtccgg atttgctgct gtgttgaatc ctgggctgcc aaaagcagct ttttctgatt 2696581 ctcttgatat tctttgtacc tttcaactgt atcaatgaat tctttcagcg tgtttttggc 2696641 ttcctccgcc gtagaagctt tttcttttgt cgtgccttgc gcttcattca ttgatttctt 2696701 cagctcatcg attaagtctt tttgctgttt gatttcacct gctaaatcat tagagcttgg 2696761 tttgtaaaag ttgtacatga cattctggaa ttcagattct ttattgacga tcttgtcaaa 2696821 ttctcctctg atgttgtcca ctttttgcga aacaaaattc cagtataagg ccgacatttt 2696881 tttgttcatt gtcttttggg catcctcaag ctcacgctga actttttctt tgttaaccgc 2696941 attcaggtta tcttgaatgc tgaattcgag cgttgccttt tgaggatggt ctttgtcata 2697001 gctcaaaatg ttttttgaga agtctgaggg aatgtagaca atcgcatcgt atttctttga 2697061 agcgagaccg gtctcggccg cgcttcggtt tacgaccgtc cacgaataat caggacgttc 2697121 acccagaacg gccgctactt ccttgccgaa ctgggcggat ttgtcctctt catcagactt 2697181 tacctcatca ctcaatacgc ctgtgtcttc attcaccacc gcgatttgcc gggtagaatt 2697241 gactgctttt ttcgttgggt cgtctccgat aaatcggaaa aacaacaccg gcagcagcaa 2697301 aatgatgatg acggcggata ttaacttgat caagcttttt cgttgttctg tcatctagca 2697361 ctctcccttt cagcagaaca taaaggaatt tgaacttttt gctccttccc gttttccaca 2697421 acatatccga agcccggctg aatctcaggc tcctgtcttt ggtacgggag aggaatgaca 2697481 ttttgctcag actttttcat cagcagaatc gcgtggcgga tttgcttcat ctcagtcgtc 2697541 aaggagtcat agccttttga gaattcgctg tggtttccgc ccgggataaa gctgaaccca 2697601 agatgagcgt atgatttcat gaagttagcg agacgatctt gtattctcgt atcaatcgtc 2697661 tgctggaatc tcgttatccc gtcaatcatc agcacgactt gtgagaatcg cagattttgt 2697721 gcgtctcctt ggcggacggc ttctacatac atggcttctc ttgttttgaa aatgtcttct 2697781 gctgtttcaa tccactgctc aatatcttct ttcgtttcca aatatgaaac atctgattcc 2697841 ttcgcataat gagataagcc gcggtcaatc gagtcaaaca ggccgatcat ttcggtttca 2697901 tcatcaatca gatgttcaag catgactttt aggacgtttg ttttcccgcg ctgagtttgg 2697961 cctaaaatca ggcagtgctt atgcttgccc aaatcaaaat agactgggct gactgtttct 2698021 tcatgaagcc cgatcggtac agataaaggc ttgcgttcca gcttgaagcg gatagacaat 2698081 tctctcgtcg acaagctctc aggcagcatc ggaatcggtg ccggctgctc cattgaagca 2698141 aatcgccctt gaagtttctg tacgtctgat ttcagctcgt tgaacatgcc gatatcatca 2698201 tcggcgtcaa caggcaggaa catttgcgcg aaataaagct cttccttttg aatgatgacg 2698261 cgtcccggaa tcggctcaag attgaatttc ggacggccgt aaatggaata tccttctgat 2698321 tgatccatga gataatggac aatctttgtt ttcaagttat ttaacaatga ctggcggaca 2698381 gcattcaccc gcgttgctgt cagcataaag tagataccca agctttgtcc gtctctggaa 2698441 agctggacaa attccgattc aagctcatgc atctcatcct tgacaatgtc aaagttgtca 2698501 atggtgataa aaatgaatgg aagctcttct tcgctcagcg cattgtacat tttgatgtgg 2698561 ctgatttctt tttcccggaa caaacgttta cggcggtcaa tttcttcttt gatgcgaatc 2698621 atgaactttt caattttcct tgactggtcc atcaggaagt aatccgcggt atgcgggagc 2698681 ttcgctaatg gcagcagcgt tccgtttccg aaatcaaaga tatagacatg aagctcttca 2698741 ggtgtgtata cgtccgcaaa actcatcagg aacgttgcgg ctgcaatcga ttttccgtag 2698801 cccgaagagc cgaagatgcc gatatttcca tcttccatca tcttataagc aattggcgcc 2698861 tgtctttgca gatcaggttc atcgacatac gcaaagtgga aatggtcttt ttcgtttgaa 2698921 gggaaaagag tgcgcggaat acgttccgca agcggcggca gccaagggct tggcagcttc 2698981 tcgattccca tttcatcttg gatgcgttca atttcgtcaa ctacagcttc gatttcggtt 2699041 tgaacgtctt ttttcgcgtt atcttcggta tcaacctcag aaagcgggat cagacccgta 2699101 tctgtgacga tcgcgatttc atcctcggta ccgtagactt cctctaagta aggcgccccg 2699161 ctccatgcag attggaacag ctcatacact tcattgtttc cgacctgcaa atagccgcgg 2699221 cctgttacgg taatgtttgc ggcatcgctg tttttcaaaa tttctttact gtcggtggca 2699281 tcctggacct tgagcgctac tttaaagcgc gagttactcc agatctggtc gtcgatgatg 2699341 ccgcctggct tctgtgtcgc caaaatcaaa tgaacgccga ggcttcgtcc gatacgcgcg 2699401 gcactgacaa gctccctgat aaaatcaggc tcctcgcttt tcagctcggc aaactcatca 2699461 gaaattaaga acaagtgagg catcgccact tctgctttcc cttgcttgta tagctttgta 2699521 tagtcattga tgtgattgac ttgatactgg tcaaacaggc gctgcctttt ttttagctcg 2699581 cttttaatgg aagcaagcgc acgcatactg aagtttttgc ttccttcaat atttgtgatc 2699641 gtgccgagga ggtggggaat gttacggaac ggctgcgcca ttcctccgcc tttatagtca 2699701 attagtaaga aagccgcttc atgcggatga aaatgcactg caagtgacaa gatgtaggtc 2699761 tggagaaatt cacttttccc tgatcccgtt gtccccgcaa gcaagccgtg cggaccgtgt 2699821 gctttttcgt gaaggttcag atacacaatg tcatctttcc ctttatagcc gatcggcact 2699881 gacagcgact tcgacgattc acttgtcagc catctttgct gaatgccgat ttcttttact 2699941 tccttcgcat gaaaaagctc caggaacgat accgtttccg gaatggaatt cgtaatgccg 2700001 acctggtggt tcagcgtccg cagtgtgcgt gaaaaccgtt cgttatcctc acgctgatga 2700061 tgatcgagac ggaacggaat tcttaccgct tttttctttt gtattaaaat gtcgccttca 2700121 tgctcattaa tgtagcggac aagagttgta atgttttccg acaagctttc ctttgtttct 2700181 gcagcgacaa ttgtcgagat gcccagatgc tcatgctgcc cttctaaata ttcgagaatg 2700241 acatgctcag agatcagctg ctgattcgtg atgacaaata caaaatgcgg tttgaactgc 2700301 agtttttctt tgtcatcttc gagatcacgc tctctgatca attcgtaaag tgaagacagg 2700361 agctgatctc gggtttgctc attataaata aatccttttg cataaatatg gggcatttga 2700421 aattgcggaa gccacttcat ccactcccag tctttatact cttcttcatg aaaaataaat 2700481 acgaaacgca aatcgtgata gctgttaaag aacgacagct gtccgattag ctggtgaatc 2700541 tcatttttca caatttgtga tttaccgaca agccccatcg gaccttctgc caaatcgacc 2700601 gtcaccggcg cattacggat atctttatag acgcgttgca tgtgctgcga tttctccatg 2700661 aggtcatcga tatcacgatt cgccaagtct ccgccactca tattgatttc atagcttgac 2700721 ggaactgttc ccgtcccaag ccgcagctgg agataatcct tgctttcaag tgatttttcc 2700781 cagatccggt cactgatttc acttgttaag tatttcattt gttcaaatga aggaaagtga 2700841 aattcaagaa cctgcttttg cttttcagca agtgcctgaa gctctttccg cttattgtct 2700901 aagtaaagct tatatacacg ctcccgtttt tcctcgcgtt ttttccgctg gtttttatca 2700961 cggaaatatt gcactgtcga ggtaatgaga gtcatcataa acatcgccaa agaaacgagt 2701021 ataaatatgc cgcgcggctg gatgatggca actacgccca tcacgatcag catcacaagc 2701081 ggaggcagga tgacgagcca cagccctctg ttggtttgat cgctctcctg agagggaaaa 2701141 ctgaaagaaa cgcggtcatc cggcagatcg tataccatcc gcggcgttct tctgtactgc 2701201 ggatattttt tctgcatctc tgtactcggt ttgaccgttt ctgttaacgc tgtttcaaac 2701261 tgggcataat gaacaatttc taaaaggtct tgttccgtca ccctcatttg cgtgaagttc 2701321 cagaatattt catcccccgg cttgagcggc gtattggcgt tgattttctc tccgttcaag 2701381 aagatcgttc cgctttcagg gcggaccgac cagctgccgc ctgcacggag caaagaaaac 2701441 gtgctttgtt ctgcaaatgc aaaatcttgc ggattcagat aaatatctgc attcgttttt 2701501 tctgaggaac atacaatttc atcccgattt cccgtaaaat aaacggattt ctcaggttca 2701561 ctgcccgtca atatcaagcg tatatcctgc tgatccgttt ggagagtaaa tgatatatcc 2701621 gtctcaatcg tgccgagaca atcatttccc aggaaaactt cgtattggcc gccggattcc 2701681 tttcttttaa gagaaatcac tccgctatta aatggaatgg tgctgatcgt aacagaatcc 2701741 ttcacatcag gccctatggt caccggatga gacgacggga ggttagacag atttaatttt 2701801 tgaacgttat tttggtaaaa aacccataat agactcaaat ggcgaacccc cttacggccg 2701861 aatggcagca tgcgatgacc tgcgcttcat gtctcacgtt atttgtcatc ttttttctca 2701921 tctttctttt ctgtttcttt tttctcgtct tctttttcct tctgttcttc ttttttcgct 2701981 ttttcctcgg ctgcggcttt ttcttctgcc gctttctctt ctgcttgttt ttcttcgtct 2702041 gtttgtgtct gttcttcgct tgtatcgact aacgatgttt cagaattaga ctgtttattt 2702101 tcttgacgtt ctttttgggc tttttcaagc tcactattta ctgaatcaag ttctttttgt 2702161 atgtcttcat catttgtatc ctcagataaa agctgctgtt tatatttagc tagggcaaag 2702221 taaatataat cattgtattc cagcttacgg ccgatactga tcgcttcttt gtattctcct 2702281 cgaccataat caatccaata taagaaatgc tgagggtctg attgaagggt gactaaatta 2702341 ttttctatat ttttggtttt tgcactcccc aggttttcga cctcaacata ggacgtcgcc 2702401 agctgatact gcaccgattc aggcaggctt tccgcatcgt acttggacag tgtgctgatg 2702461 acttcactgt actgcttgtt taagaacgca cggttgctgt ccactatcgc ctggtgcttt 2702521 ggctgcgcga aaaataaggc gtacatcgaa taaataagtg ccggtacaag caaaacaatg 2702581 agccccaggc cgatatatcg ctggatgttc cacttctttc tcgggatatg tatgtatgtt 2702641 tttgctttgg cttcgagctc atcaatatgg gtttgaatca gctcgagcaa atcatcatag 2702701 gattcagcat ctaatatcgc ctttgcctct gcggagaacg tcagcgtttc attgaatttc 2702761 aggtagtctt caaacgcaaa agcgccgtca actgccaaag ccgctgccgc tttcagctcc 2702821 tgccatactc tttcctcatc acgctcgtaa ggaggaatgc tttcttttac tccataatgg 2702881 agaaaataag gcgtaagccc tttatcgaat acaatgtttt caggagcgac aatcaaattc 2702941 agcctcgaca gattgtgctg ctgtacggct tgaacaagct gataggcaaa ctgccattta 2703001 ctttttttat ccttagcttt catgaagcgg aatgctttat aggaggaggg aggttggatt 2703061 gtgatgatta cttcatcatc cgtcacatcg atttctttat gaaaaaatgg atttatatct 2703121 ttgatcacgt tagcttcaag accgtcgaga agctttattt tttcccgttg aaaggtaaat 2703181 gtatagccgg catctgtttt ctcggcaaca gcttctaatt ggttttctaa atatgatttt 2703241 tgttcacctg acattcaacc agatcctttc ataatatttc aagccggtct ccgtttgtaa 2703301 tgccgcaatc agacagcttg cattctccgg aaaacacctt atccttgttc accactctga 2703361 tccagtgccc ttcgcgcgga ggcatagata cgctttgggc ctgccaagca atatcaatta 2703421 cttttttcac cgggtggtaa tctgacaatc tgagatcaaa gacactgccg ttataatgtt 2703481 tcaaatctat tgtaatatca atatacattt aggatcaccc ttacatagaa agagcgccgt 2703541 cttcttttga atcaggcgct ccttcccttt catactgtta tccgcggatt tgatttgcga 2703601 tgtcttggtc agtagactca agtgtatttg ctgtttgatc aagctgctga ttcacatctt 2703661 gaagcaaatc tgacattttg ataaatgaag gtttgagctg ctcgtattga tctgcgaacg 2703721 cttcgcttga agcaccttcc cacatgcttt tcaaatcaga gatcattcgg tttaaacgat 2703781 caacctgatt taatacttct tggctttcaa cgccgtattg cttcgccatc gctcttagct 2703841 cttcgggtgt gacacgaatt aatcctgcca tattcctcat tacctcctgt gccatcagcc 2703901 taaatatggg ctaattcact tatttttaga acgtcattat tataaaaaca gtttttcggc 2703961 atagtcaaac aaatatgttt taattttaca aaatgagtcc aatggtttac cccgaatcac 2704021 tcaaaaatga catatactgt aaagtaaata ggtttatttt cttaatcttc tcttcattct 2704081 ccgaataatc caaaagaccc aaataactct ccaactccca aaaaaaacct ttcagaaaat 2704141 ttgatgctac agcaccattt ctgaaaggtt cagttttttc tttccttaat tagtcttgcc 2704201 tccgatgact ttcttagaag attaatagga taagctgtcg tattatatga gacatacact 2704261 gtcctgcaaa aaggcgatta caccgccaaa tgtatataga acgtttctct catgaaattg 2704321 tttttttgct tctgttcttt gttgttgatt ttcacaaaca acaacaatca taataaaagg 2704381 aaggggatga gatgtcaaag agaaatcaag cacgaaaagt agggagattt atgaccatgc 2704441 cgaatgatcc gtttaaatat agttttgaca gacttgaaga tgtggctgat catatcagcg 2704501 acgttctgcg gtgcccgatc accatagagg atgttaacca caagctgctt gcctacagta 2704561 cacacagcga ctgcacagac cctgcccgga cgtctaccat tattggcaga agggtaccgg 2704621 agaaggtgat taacaagctg tggaaagacg ggacaattcc tgctctctta aaaacggacc 2704681 agccgatcag agtcaagcaa atcgatgaag tcgggctgag caatcgcgtc gctatttcga 2704741 tttggaaaaa caagcaagta cttggcttca tatgggcgct tgagatccaa aaaacattgt 2704801 ccgatgaaga tctgctgaca ttgcaaatgg cagcaaaagc agtgaaaaac aagcttctca 2704861 aacttcaaat cagaaaaacg aaaaatgaag aacgcagcca agaatttttc tggaaaatgc 2704921 tgaccggaca catccatcag gaggatgata tggcggatgg gttccataag cttggaatgg 2704981 ccgctccttc agagttttcc gttatgatca tccgcataaa tggcgagctg actgaaaaaa 2705041 tcgaacagca gctgcaatat ttacaggaaa cgacccagca ggtttacgtg ctgctggcga 2705101 ccgtagattc caatgaactt attatattaa cctcacccaa aacagatcat ccttttcaag 2705161 atttaaaaca gtttgcttta agtacgcaaa aacagctgaa ggagcggtat aaaatagaag 2705221 acgtttctat cgcttttggc ggaatataca actctatttc ttttgtctcc cgctcctatc 2705281 aggaagcatt gtccgtctta aaaacgaagg aacggttcgc tgaagagacc aaacatcttt 2705341 tcagcttttc tgagttaggc atttatcaat acttagatgt cttaaatgaa aaacggaaac 2705401 aggcgggcca ttataattac tcgctttcca aactggaaca atatgaccgg gatcaccagt 2705461 caaatatggt agagacgcta gagcgcttta ttgaagcgga cagcaacgtg aataccgctt 2705521 ccaagctgtt aaatatacac gttaatacgt tgaattaccg actcaagcgg atcagccaga 2705581 tcgctgaaat tgatttgaaa aatgtgaatc aaaaattcac catctattta gatatcaaac 2705641 ttcggcacat ggatttgtga aatttcacaa atccatgttt ttttattttc ttaatcaaac 2705701 aaagaatttt ccaaaatatc aagctacact aaaaatatca catatacagg aggagacaga 2705761 tatgatcata ggggttccta aagagataaa aaacaatgaa aaccgtgtcg cattaacacc 2705821 cgggggcgtt tctcagctca tttcaaacgg ccaccgggtg ctggttgaaa caggcgcggg 2705881 ccttggaagc ggatttgaaa atgaagccta tgagtcagca ggagcggaaa tcattgctga 2705941 tccgaagcag gtctgggacg ccgaaatggt catgaaagta aaagaaccgc tgccggaaga 2706001 atatgtttat tttcgcaaag gacttgtgct gtttacgtac cttcatttag cagctgagcc 2706061 tgagcttgca caggccttga aggataaagg agtaactgcc atcgcatatg aaacggtcag 2706121 tgaaggccgg acattgcctc ttctgacgcc aatgtcagag gttgcgggca gaatggcagc 2706181 gcaaatcggc gctcaattct tagaaaagcc taaaggcgga aaaggcattc tgcttgccgg 2706241 ggtgcctggc gtttcccgcg gaaaagtaac aattatcgga ggaggcgttg tcgggacaaa 2706301 cgcggcgaaa atggctgtcg gcctcggtgc agatgtgacg atcattgact taaacgcaga 2706361 ccgcttgcgc cagcttgatg acatcttcgg ccatcagatt aaaacgttaa tttctaatcc 2706421 ggtcaatatt gctgatgctg tggcggaagc ggatctcctc atttgcgcgg tattaattcc 2706481 gggtgctaaa gctccgactc ttgtcactga ggaaatggta aaacaaatga aacccggttc 2706541 agttattgtt gatgtagcga tcgaccaagg cggcatcgtc gaaactgtcg accatatcac 2706601 aacacatgat cagccaacat atgaaaaaca cggggttgtg cattatgctg tagcgaacat 2706661 gccaggcgca gtccctcgta catcaacaat cgccctgact aacgttactg ttccatacgc 2706721 gctgcaaatc gcgaacaaag gggcagtaaa agcgctcgca gacaatacgg cactgagagc 2706781 gggtttaaac accgcaaacg gacacgtgac ctatgaagct gtagcaagag atctaggcta 2706841 tgagtatgtt cctgccgaga aagctttaca ggatgaatca tctgtggcgg gtgcttaatt 2706901 cacaataagc ttgcagaaag atttctgcag gcttttttat tttttaaaag gaaaaaagag 2706961 accatttcac gaattatgac tatgaagttg atcataaagg aggattcata tggctgttca 2707021 gcaatatggc gtgttaaaag gcatagtatt agacatgaag cgggaaacag atgatgacag 2707081 tcctcatttc caagtcaaaa tgctcggtga agagaatacg tattacaggt gcgccatcaa 2707141 tgtgatgtcc agttctgagg aatctgaagt attgtatttg gctgacgatc agtttgattc 2707201 gggctcaatt accatccttc cgaacatgcc gtatggatat acaaggatca atgaagcaaa 2707261 ccgtgaagtg gcactggatt atgtgcgggg caatttgttt gacccgcggg aaatgaagcc 2707321 tttgcctcat gaaatcacgg gacctgataa tgatttaaat gattttattg aaacctatat 2707381 gaagaaagca caagatgaga aaacgccggt ttatatattc ggttcaaaat tcggccctga 2707441 acaggctgca gataaaatat tcggctttac cccgactaac ggaatgcaca atatccatat 2707501 gaatcaaggg aatgcaatgg atacccgctg gaaaaaagac aacggctctt ggcatgacgg 2707561 gggtattctg attcagtttg cagatcagtg ggccgctgtg tttttagcgt ttttatccca 2707621 atcttggtgt accgatgaaa acggaaaccc tgtcagagat tgtgatcata cccaaacgtc 2707681 tgcgtaagat agaaaaagag actgcggcaa gcagtctctt tttgataaga ttacacattt 2707741 tcaacagtct ttaggctgtt tggcctcata tcgctccaat gcgattggat atagtccaaa 2707801 caagcttcac gccctttttg ctcatgaacg actgtccagc cgctcggcac atctataaaa 2707861 cccggccata gggaatattg gccttcttca ttgaccagca ccaaatatgt gccatccgca 2707921 ttttcaaaag gatttgccat tctatttctc ctcccttatt tattcaactc ttccaatttg 2707981 acagcgagaa ccttgccgat ttgagccaga ggttcaggct gacataaatc tttatgacgg 2708041 cagtcgatgt cgatttgttc aatctgtccg ttaatataag gcttccacga gtcaggttca 2708101 atcgggtcaa accattcagg aatgattgtt gatctgaaaa acaaaacatt tccgcggaag 2708161 gttttcggct tataggaacc taaaatgccg acagaattta catacgtatt cttcaaattt 2708221 aaaatgaccg tttcatccag gctcgcaagc gcactgccgt cacggcgaag aatctcaatc 2708281 gccgcttcaa aatctagcgg tttttcccct aagctgtctg gatcataccc gcctaacgcc 2708341 agaagggcaa taagcgcttc ctcatcatcc ggtgcctctt ttataggaag gaagtggttc 2708401 ggataggcgt ccagcatcac caacagggat acttcttctc cttgattttg cagctgggta 2708461 gccatcgctt gaacgacatt cccgcccagg gaccagccca gcagatggta cgggcctttt 2708521 ggctggaccg ttcggatttg tttaatgtaa tcggcagcca tgtcatcaag tgttttcgga 2708581 agctcctcgc gctgcccgat tccccgtgcc tgcaagccgt agatcggata atctgttcct 2708641 atattggtca tcaaaccggc ataacaccag ctgagccccc ctgccggatg aacacagaat 2708701 aaaggaggct tgtctccgct tgttcggagc ggcagcagaa cgtcaagagc gctttggctt 2708761 gatcccattt caagtctttc agcgagcccg gctacagtag gtgcttcgaa caagttgccg 2708821 atgctgagtt caacgccgag cgcttcacga atgcggctca tgagctgtac agcaagcaag 2708881 gaatgtccgc ctaaatcaaa gaaacggtca tcaatgccga cacgcggcaa gtgaagcacc 2708941 tccataaaga ggtcacagag aatttcttcc tgcggcgttc tcggtcctcg tcctgtcact 2709001 gccgctgcga aatccggagc gggcagcgct ttacgatcaa gctttccatt cggtgtcagc 2709061 ggcaattctt tcatcgtcac aaaggcagca ggcaccatgt aatccggcag tctctcagca 2709121 gcatatctgc gcagttccgc cgtatcaaat gtttcttccg aagggatgac ataagctgct 2709181 aaccgtttat ctcccggctg atcctcacga acgatcactg ccgcatcttc aagctgcgga 2709241 tgctgaacaa gcgcggcttc aatttctccc aattcaatcc ggaatccccg aattttcact 2709301 tgatggtctg cacggccgac atagtcgaga gaaccgtcag cgcggaggcg ggccacatcc 2709361 ccagtgcggt acatccgggt gcctggagga ccgaacggat cagctatgaa gcgttcagat 2709421 gttaaaccag gccggcctag ataacctcgt gctaaccccg ctcctgatac atacagctct 2709481 ccggcaacac ccggcgggac cggctgcagg cgttcatcca gcacgtatac accaagatcg 2709541 ggaatgccgc agccgatcaa gctgtttgcc cgtaaagctg ccatgcttcg gtctaattcg 2709601 atatagctca catgcaccgt cgtttctgta ataccataca tattgataag ctgcggtcta 2709661 ttttcagggt ggcggttgta ccaatcctct aaacggctga gttcaagcgc ttctccgcca 2709721 aaaatgacat agcgcagact gagtgcctgt ccgagatccg gctgttcccg ttccgcctgc 2709781 ataaactgat agaaagcaga cggtgtctgg ttcagaacag tcaccccctc tttgacaagc 2709841 aggcgcagaa acgcttctgg cgatctgctg acgtggtgag gcacgattac aagacgtccg 2709901 ccatgcagca gaggacccca gatctcccac accgaaaaat caaacgcata ggaatggaac 2709961 atggtccaga tatcacctga gctgaaacgg aaccagtgct cggtcgctgc aaataaacgt 2710021 gttacatttt ggtgaggaat catcacacct tttggaacac ctgttgagcc ggatgtataa 2710081 atgacatatg ccgtattcaa aggggaaagc ggctgagtcc tatccttatt ttttggatta 2710141 cctgcagggt acgtgtttag tttctctgcc agctcgggat catccagcac gattttcggc 2710201 acgttttcaa ctggcggaat gtgatttgca gctttagtgt tcgtcatgat aaacgcaggc 2710261 tgtgcatctt ttagcataaa agcaattcga tcagccggat aatccggatc aagagggaga 2710321 taagctgccc cggcctttag caccgccaat aggccgacag ccatttccaa cgatcggggc 2710381 agtgccaatg ccacaaattg ctccggcccg acaccttcac taatcatcat tcgggcaagc 2710441 cggtttgctc tttcattcag ctctgcatag ctcagttcct gattttcata tacaacggca 2710501 atggcatcag gacgtaaagc agcctgcttc tcaaattgct ctggcaaaca tgcgtgcgga 2710561 atcttttcag atacactttg ccaatcagtc accatgctgc tgtgttcctc tggcgcaaga 2710621 atatccagat ttccgatttg ctcgtcagga tcagactcgg cagcctccaa caggcgcatc 2710681 aatcggtcag caagagcctg agcagtttcc cgtttgaaaa gatcagtgct gtattcaagc 2710741 agtccttcca ttccgtttgg tgtcccgtca gcaaggcgat cttcactaat ttccagcgtc 2710801 aaatcaaact tggcagaacc gacactgttg attcgcaggc tgctctccat atcaggaaga 2710861 tgcagttcag cgtccggtgt gttttggaac gcaagcatga tttggaataa aggatgcgtc 2710921 gcacgcgaac gagccggatt gagcacctct acaagtctct caaacggcag atcctgattg 2710981 tcataggcgg ccagattcac ttcccgtact ctgtctagaa gctcacgaaa gcttgggtca 2711041 ccggacgtat cagttctgag caccaatgta ttaatgaaca gccctacaag atcgcccagc 2711101 gcatcatcat tccgtcccgc gatcggactg ccgatcggaa tgtcggtgcc cgccccgagc 2711161 cttgtcaata aagcggcgag accggattga agcaccataa acaggctcac cctatttgcg 2711221 cgagccagct cctgcaatcg cttgtgaaac tcgggctcaa tacgaaaatg aatcgtatct 2711281 ccatcatgac tcggctcagc cggacgtgaa taatcggttg gcagttcaag ctgatcaggc 2711341 aggtttttca aggtttcttt ccagaaagca agctgtccgg caatcaagct atttggatca 2711401 tcctcgtttc caagcagttc ttgctgccaa agcgcatagt ctgcatactg cacagcaaga 2711461 ggcgcccatt cgggagatcg tccgtggcag cgagccgcat aagctgtccc aaggtctctg 2711521 gtcagcggtg ttaaggacca gccgtccccg acaatatgat ggacgagaag aagcagcacg 2711581 tactcgtcag gaccgatcac aaaaagctcg gcacgaaaag caggttcagc tgcaagatca 2711641 aagctgtagc gtacagcttc ggcaagccga tcagaaagct ccttctcagc aatttcagta 2711701 acatgtaact cgggacaggc tcgatcggca tctaaaatat gctgatagga tgtcccctgt 2711761 gattcaggga agatcgtccg aagactttca tgacggcaga cgaggtcata aagtgccgct 2711821 ttcagcaatc cttgatccaa ctcacctgac aaacggacag caaccggaat attataagta 2711881 ggactcggtc cttccagaca atgcaggaac catagccggc gctgggcaaa tgagagcggg 2711941 atcttttcag gccgctcagc tctctgcaaa gcgggacatg cactctgcgc caaatcaaga 2712001 tgggcagcga gtccggctac tgtcggttcg tcaaagagct tggcgatacc aagttcggct 2712061 cccattacct cgcgaatgcg gctcatcaga cgggctgcaa gaagagaatg gcccccaagc 2712121 tcgaagaaac tgtcatcgat accgacgcgt gccaaaccga gaacctctgc aaacaagtca 2712181 cacaatatct cttcctgagg agtccgcggg gcccgatcac tgacagatgt gctgaagtct 2712241 ggtgccggca gtgctttccg gtcaagcttg ccattaggtg ttaacggcag ctcgtccatc 2712301 tccacaaacg ccgacggtac catataatca ggaagactag cccccatata acgacgaagc 2712361 tctgcagtat caatagcagc atcagcgact acataagccg ccaatcgttt gtctcccggc 2712421 tgatcttccc gtacgacaac cgcggcctgt tcaatgtgcg ggtgattggc aagcacggca 2712481 tcaatttctc caagttcaat tcggaatccg cgaattttga tttgatgatc cgcccgcccg 2712541 atataatcca aagacccatc ggcgcgccag cgggcctggt ctccggtccg atacatccga 2712601 gttcccggcg gtccgtatgg atctgcaacg aagcgctccg ccgttaaatc aggacgatgg 2712661 aaataacctc tggccaagcc ggttcctgca atataaagct ctccgacaac gcccggcggc 2712721 accggctgca atccattatc aagcacatac acctgcgtgt tccaaatcgg tttcccaatc 2712781 ggaggaacgc ccttcagccc ttcttcaaga aaagctgcgg cagaccaaat cgttgtttca 2712841 gtgggaccgt ataagttcgt gactgaacaa tgaaggtctt gaagttcctg caaaagaccg 2712901 ctcggcagcg cctcgcctcc tacaagcact ctaagccccc gaagtttctc aggttcactc 2712961 gttaccaaag cgtgccacag tgtcggtgtc gcctgcataa tgttaatatc gaaattttca 2713021 atcatttgag ctaatgcctg cggctcacgg atcgtttctt tctttgcgat cacgatttgc 2713081 gctccgctaa tcagcggaag atataactcc aatgctgaaa tatcaaaagc gacagtcgtc 2713141 acagccaaca gcctgtcttc ttctcctaga gaaaatgcct cctgcataga cagcagaaaa 2713201 ttgcttaagc ttttctgtgt cacaacgact cccttcggtc ttcctgttga tcctgaggta 2713261 tagatgatat acgcaggatg gtcaagcgaa accgatacat cctgattttc cggcgaatag 2713321 cgttttataa tctcctgtgt aacagcctga tcaagcacaa gctcaggtac agccaggtca 2713381 tcaggcagac tggctgctat ttcctcagtc gttatgatgc atgaaggttt cgcatcctcc 2713441 agcatgtaag aaatgcggtc ggctggaaac tccggatcaa gggggagata cgccgcacca 2713501 gtcttgagca caccaagcat tgaagccacc atctcagggg aacgcggcag cgccaaagcg 2713561 acaaattgct ccggaccaat ccctttttcg atcaacagac gcgcgaggcg gtttgcctct 2713621 tcattgagct ttcgatagtt gacttgaatg tcatcacaca tgagagcgat acgttctggc 2713681 gtaagaactg cctgcttttc gaacatgtcc tgaaggctga ccagcttctc ggattttgcc 2713741 gtctcattcc atttagaaat gactttttct ttctcctctg gcaacagaag ctccatttgc 2713801 ccaatcagca tgtcctctcc ggcagaagcc gtttgcagca gctgcaaaat acgctgctga 2713861 tgaagcttaa tatcagactc actgtatacc tcgggattcg catcaacatc aattcgcagc 2713921 ccgctgccgt ctgttctgtc atatacattg attgatagat catcaacagg accggctgaa 2713981 agattatgcg ttgtgccccg gacgccggca aagtcgagac cgtaatcaaa cggcataaga 2714041 ttgatttgag ggccaaataa tctatgattt tctcctatca atttcagatc gcgcctaagc 2714101 tcttcatggc gatacttatg atgtcgccga atactgcgga tttcccggga aatttgctga 2714161 atcagttcag aaaagctcat cgaagagctt accgtcagcc ggagcgggag aaggttcatc 2714221 accatagccg gtacattcag tgacgcggac cctatccgac ccatcatggg caggccgagc 2714281 acaacatcct cagagccggt catacggtgc acataaacag ctgacaccgc aatcatgact 2714341 tcatgccagc ttcctgagaa atagcgcgcc gcttctttta acgcgtttac atcagacgga 2714401 ggcagatatg ccgtatgacg aagaaaactg ttagatgttc ttggcgcccg atcagccaag 2714461 ctcacaactt caggtgcatc tgcaaaacgg tccagccaga attgacgatc cttctcatac 2714521 tgctctgatc cgcgataatc tgtatcctcc tccaaaatgg cctggagaga cccaaaggaa 2714581 cggcttttag ctgtttgtcc ttttataagg gcagtatatg tacttgccac acgctgggct 2714641 atcagggaaa aaccgaagcc gtcgatcgct atatggtgaa tgcgctgata ccaaaagaaa 2714701 cgatcaggcc cggcaataaa cagagcttca ttgaacaaag gggcataccc taaatcaacc 2714761 ggctttgcta aatcagcttt catccagttt aatgctgttt tttccggatc aggctcagag 2714821 ctgacgtcaa tgacgtgcag ctgtacatcc ggagacgggt ttatcatctg ccaaggcccg 2714881 tccatatttt caccgaagcg gacatgcagc gattccgctt ccttgatcac gtgccgcaaa 2714941 gcttcttcaa aaagagcaat attgactggt ccattgattt ctatatattc cgctgtattg 2715001 tagattggat tgtccggatc aagctgctga gcaaaccata tgccagtttg cgccccggtc 2715061 aaagaatatt gaagatcttt tgtatcaggc atccgtttgt ttaccctcct tttataaata 2715121 atccgcgttt ggcagcactt gctggctgcg agttgtgagc aatttctgcc attcttcgat 2715181 cgttgggcgt tcagccaatt ccacgaaagt cacctctgcc ccttcacggc gccattgttc 2715241 caccaatgtc atgatcctta ccgaatcaag accacgatcg agcaaatcct cttgatctgt 2715301 gatgtcttcc ggtgtttctt gtagaagctc agcaatttgt ttacggatat tctcacatgt 2715361 aaacacgttc tttttgccag tgtttgctga cgttttttga acgtctgccg gcgcattctg 2715421 cagctgatca agaagactgt cagtcatcac ggtaaacgca cagcgtccag ccgcatattc 2715481 cagcgccatt tgatgttttt ctaatgaaaa atcagcaact gcatctccca caaaaaaggc 2715541 tttaatatcc tccataaatg cttcacatgc tgtaacaaga cagccgatat gggcgtaaat 2715601 tcctgtaatg atcagctgat cgcgtccctc tttgcgcatc atttcaagca gattcgttct 2715661 cttaaacgcg ctgtatctcc attttgtcag cacaagatca tcatcctctg gtgccagctc 2715721 ggttataatt ttctcctcat aaggaccgct gtttaatccc gggccccaaa agtctgtcag 2715781 cagcgcacgg tcatccggat tttggcttcc cggctgtgcg gtatagacaa caggaatccc 2715841 aagctgaaca cattgattct tcagctttcg tatattcgct gaaagctctg ttaccggaga 2715901 cgctcccgct gtgaaagcat caacaaaata gttttgcata tcgtgtatta acaagacagc 2715961 ccgattcgga tcaggcaccc atgatacttt gttttgcggc atatcagatg ctgtcggcat 2716021 ttgatacggc tgaatggcag gtatagccat atgaacactt cctctcaaat tgttgtttta 2716081 ttttttaaat cctgcaagaa gcttctcgga aatggcttca cggagcgctt ttttgctgac 2716141 ttttcctact cctgtctgcg ggaaggattc gacaaattca actcgatcag ggattttata 2716201 tgccgccagt ccgcgctctc tcaaaaatgc tttaagctct gcggcttttg gggcttcatc 2716261 ccggggaata atgaacacac aagatctttc gccaagaaat tgatcaggca tggagaccat 2716321 tgccgcatca tggacagccg gatgcgccag cagatgattt tctacctctt cagccgcaac 2716381 cttttctcct ccacggttaa tttgatcctt cgcccggcct tcaacgacaa tatagccgtc 2716441 tcgtgtcagc ctgacgatat cacccgtacg gtaaaaaccg tcctcagtaa atgaagcggc 2716501 gttatgctct tctgccttat agtaacctcg aattgtatac ggcccccgcg tcagcagatg 2716561 gcctgtttca ccaggtttta cgtcgcgatc atgatcatcc caaacacgca tttcatcata 2716621 tggagacatc ggttttcctt gggtgttgac aatgatctcc tcaggatcat ccaatctcgt 2716681 ataattgacg agaccctctg ccattccgaa cacctgctgc agcgtgcagc cgaaaacagc 2716741 ttttaccctg cgcgcggctt cagcactaaa cttggcaccg ccgacctgca gcacttgaag 2716801 gctggataaa tcatcacggc gtgaggatgc cgcatccatc cataccatcg caagaggcgg 2716861 aacaagagcg gttatcgtga ccttttcccg ttcaattaaa ggaaatgcgt catctggact 2716921 tggagaagga gataatacca ctcttcctcc agcgtataat acgccgagaa cgccgggtga 2716981 gctcagcgga taattgtgtg ccatcggcag cgcggccaag tacaccgtgc tgtggtcgag 2717041 ccagcagacc tccacactcc gcttcaggct gtatatgtag tcatcgtggg tcctcggaat 2717101 cagtttcgat agcccggtgc tcccgccaga aagctggagg aacgccacat ccgatgattt 2717161 gacttcaggc agttttacag gttctgcatg caaatcctcc agcggtaaaa attcctctgc 2717221 ctcacctgcg acaatgatgt ttttcaaagt cggcagcttg ctttgaacct gtctggcaag 2717281 cgaacggtag tcaaaaccgg aataagcgtc gggaatgata tatgcagccg cttcagcaaa 2717341 ctcgcaaaaa tatgtaattt cactgcttcg atgagaaggc agtgcgaaga ctggaagcgc 2717401 ccccagacgg aaaagcgcga aaatgacttc aaaaaactct ttgatatttg gcaactgcac 2717461 cacaacacga tccatctgtt gaatgccgag cttttgaaat ccggcagcca ggcgatcagc 2717521 ccttgtgtca agctctcgat agctccaatg ggtgtttccg catgtaatgg caatgcgatc 2717581 accatatttg gctgcccggt cccttaacaa atctccaaac gtctcaccgg cccagcagcc 2717641 gttctttcga taggtctcag ctaactcatc aggccaaggc gtaaatcctt tcagcatgtt 2717701 gtatccctcc agcaattcat tctgttcata tgtgatccac gcccattgcc cgcagcattg 2717761 tccgaaactt tgcggacgtc tcctgaagct cgtcctcagg ctttgaaccg gccacaacac 2717821 cagctccagc atacaggcgg agtgagcgtt cttctgcttc tgcacaacgg atggtcacga 2717881 tccattctcc gtcaccggca tcgtcacacc atccgaccat gccggtaaag aaaccgcggt 2717941 caaatggttc aatgctgaga atcgcttctc ttgcaagatc agtcggtgtt ccgcagacgg 2718001 ctggcgtcgg gtggagcgcc gccgccaatt caagtgcggt tacagacggg tcggaaagct 2718061 ctcccttaat cacgctggac aggtgccaca tcgtttccgt tttgatcagt gaaggcttct 2718121 ccggaacctc cagcgtccgg cagaaaggtc tcagcgctgc cgcaaccgcg tcagcgacaa 2718181 ccgcgtgctc atgaagatcc tttgcggaag aaagcaattc agctgcccgg cgctggtctt 2718241 caacaggatc attactgcgc ggtcttgagc cggctaatgg gttggaaacg acctgtgttc 2718301 ccatccttga aacgagaagc tccggacttg ctccgagcaa tgttctgcgg ggagacgttt 2718361 cctcctgact ggacacgtct gcggcaaacg tgtagccatg cgagttatgc tgagccagat 2718421 ggcgaagcaa ttcatccgtc tgaatcggtt caggcgatgt caaatgcagc gatctggaca 2718481 ggacgatttt gctgagtgtt ccatcggcaa tgcgtgccag cccttgttca acaccatttt 2718541 tataatcctc aggttcagga acaggcttta tgtggtatgt atgcccagcc tgctgttcct 2718601 tttcctcatg atcaaattga agcggtcctg accagcgcac ttcttcaggt acaacgagcc 2718661 gcgctgcttt tacttgatca aaaggaacgg ccccgacaac aagcggccgg ctttgccctg 2718721 attgttttgc ctgacgtaac gcctctgcaa ttcggccaga aagggtttcc atttggtttt 2718781 gcccgtctgc ctccggtaca atttcacata tgcctttcgc taacagtaca cgatgaggag 2718841 acgctaagaa aaaggcgccc ggctgatatt catgaagcaa atgctccgct tttgtttctg 2718901 ttataacgtt ttgatccaac attctcatga acctccttta aattcagtta cacgcctaag 2718961 gtcgcgccgc catctacgca taaattatgc atcgtaatat gccctgcctg gccagaaacc 2719021 aaaaagagca ccgcatccgc aatatccgaa ggcttggcta gttttttgag cgggatccct 2719081 gttttaaatg tctcaagtga tccttttatg acttgctccg ctccattctc gtcggcccat 2719141 aatgaccact gcatgtctgt ttccgttgat ccgggagata caatgttgca gcgaatattg 2719201 tattctgcaa gctcaaggcc aaggcatttc gtaaacatca cagccgcagc ctttgaagac 2719261 gcatatgccg ccatagatgt tcttggtaca ccggcagcat tcgatccgac tgttacaatc 2719321 gaacccgatc ttcggtccat catatatttg ctgactgaac gcgaggcgtt aaatacgcca 2719381 gtcgaattca ctgagaacgt cgcctcccat tcctcatcgc taagcgaatg gatcagtccc 2719441 gggcgaagga cacccgctac attcactaaa atatcaatcg gccccatttc acgttcgatg 2719501 cgcgccgtga tctcgtcaat cgccgcgctg tctctcacat ccgcaggaaa agcttctgca 2719561 tggcggcctt ctgctttgag gctgctcaca accttttcca gcttttcagg attataatca 2719621 actgccgcaa tatgtgcgcc ttgactggca agcgtccgcg caacagcttc gcctattcct 2719681 tgggcagccc ctgttataaa agcaattttt ccctctatac cctttgcatt catatcatca 2719741 attcctttct tcgctctaaa tgccaaacag acatccagcg aaaaagactg ctgcgccttg 2719801 aaaaacgcaa tctattgata atgattatca ttatcaatta taaaaataat catatccaaa 2719861 tgtcatgtga cagtcaaata taatttcagt gacaaatatt tttttaaagg caaggctgag 2719921 tatgtctcag cccattgata gatgcggtcc gtcagggtga agcgcaaaac gcagcgccct 2719981 gctgaccaaa acaggaagaa ctgaaatatg tccttctcct gaaaactcgc aaaattctgc 2720041 ccgtatacct tgttcagata aaacggccag ccgctcataa agctcccttg cattatcatt 2720101 catccggctt ttatgatgct gctctaattc tcctgcggca agcaggatat tgataggctg 2720161 attgtttttc ttggtgagag agacgaaatg gtccgttttc ttgagaataa acggtttatt 2720221 ccaatgaatg gacggacttc ccgcgatata cgtttgaaac gcatcgggct ttgttagcag 2720281 cacctgcagc acgaaaagcc ctccgagcga atggccaaag attgtttgtc tttttttatc 2720341 aatctggtaa tctcgttcta tctccggttt taaatcctct tcaataaatc tgaaaaagcc 2720401 ctccgctccg ccatgctccg gccattctct gccgtcgggc ctttccggca gcttcgattg 2720461 ggctgttggc attgtaaaat cccggtggcg tgctgaggag aacggctccg ctgtctcata 2720521 gccaatgccg acgatcactg cagggatcac cccggttttt tcgggtcggc gtccctgtat 2720581 tcgaacggct tccgtcatcg ttccgaagac agaattggca tccagcagat aaatcacagg 2720641 ataaccagcg ggtggcggcg gcgtactagg tttcgagata aaaatgtgat aggtacggtt 2720701 ttcattgcgt gaagacatca tacgcacttc cgtaccagga atcgtaaatg cgtttgatgt 2720761 cccgccattt gtccggtctg ttgtttgttc tttcatgcag tacgacattc ctctccttaa 2720821 actaaaccgc aatgtatgat aatgattttc actatcaact agacacctca aataataggt 2720881 tttcttccaa agaaagtcaa ctttttcccg aataaaaaag gcaccttgat caaataaggt 2720941 acctgcagac tatcaatatg gaagtaaaaa cctaataaag atgcgtattg tcctatttga 2721001 aatagaacct taatcccatg taaacctttg attttgccaa gggtcgcctc tcatgtgata 2721061 gccattccgc tcccaaaagc cagggtgatt ttctttcgta aattggatgc cgcgcagcca 2721121 cttggcgctt ttccaaaaat acagatgcgg aaatacaccc cgcagcggaa agccgtgttc 2721181 aggggttaaa ggttcgccat tatgcgcata agccagaagg gaagtttccg ctaagaaatc 2721241 atcaagcggc agattggtcg tccagccctc ttcagcatgt aaaatgacgt agcccgcttc 2721301 ttcttttaca cccgcttttt ccgctatatc acaagcccgc acgccttgcc acacattatc 2721361 aagccttgac catcccgtga cgcaatgaat gtcgtttttc gattcatacc gtggaaaggc 2721421 tttgacatct tcaaagctta gcagcatcgg atggtcaacc aaaccgtata cttgaagatt 2721481 ccatttcgtc atatcttcgt aatatgggac atctccggta tgaagcacag gaaatgaagt 2721541 ggtgacgttt tgatttggcg gcactcttcc agattgatcg gactgtcttg tttttccgaa 2721601 atacatatgg gcctcctttt tgttaaccta atttaaaatc atgttgacaa tctttttgtt 2721661 ctttattact ctatgattgt gtatgtcaac ctaaggggga acaacgatga aacaacgtaa 2721721 acttcgtgcg ggagatatgg cgctgattgg catgttcgcc gcacttatgg ctgtcggggc 2721781 caacattaca tcagtagcac cctttttaca agtagccggc attccgcttt cgatgcagcc 2721841 gtttttctgt ctcttggcag ctttgcttct tggcagcaaa cgggcagcga ttgccatgat 2721901 tgtatatgca cttgtgggat tggccggagc gcctgtgttt gctcaatttt cagcaggctt 2721961 cgcaccgttt gcagggaaaa gcggcgggtt tattatctca tacattccgg cagcatttgc 2722021 agcgggatgg tttttagaac gaaacattca gccaagtaaa attcgatttc tcattgcttc 2722081 acttatcgga acggcgatca tgtatctcat cggcactacc tatatgtatc ttgcactgaa 2722141 gctgtggatt catacgccag tgagctacgg cacggcttgg ggctttatga tttggtttat 2722201 ggtaaaagat acagcgctgg ctgtgatact gtcgtttatc gcaccagcaa tctaccgctc 2722261 tattcataaa gcaaccggct ttaacagaaa tcacatatca tctacgtaaa aaccgttcta 2722321 ttggacggtt tttttatcat aacgagaaaa ggctccccag taaaggggag cctttttcct 2722381 ataaaacaag cgctgcaatc cagccaaaga tgacaagcgg aatattataa aatataaatg 2722441 tcggcacaca agtatcccaa atgtggtgat gctggccgtc cgcactcaaa cctgaagtcg 2722501 gcccaagcgt actgtcactg gcaggtgaac cggcatcgcc aagcgcagca gcagccccga 2722561 taatcgcaat cgttgccatc gggctgaatc caagctgcat gcatagaggc acgaaaatgg 2722621 ttgtgataac aggaatggtc gcaaaagaag atccgatccc cattgtaatt aataagccga 2722681 caatgagcat cagcaatgcg cccaaggact gactgtgtcc gataaaacca gctgacgttt 2722741 tgaccagtga ctcgacatct ccggttttcg tcaatacgtt tgaaaatccg gctgcaacaa 2722801 gcatgacaaa gccgataaag gccattaaaa ccattccatc agtaatcagt gagtccgctt 2722861 catcacgctt catcacaccg ctgacaaaca gaacaatcag accagcgagc gcccccataa 2722921 tcattccttc tactcccaaa gtctgagata agtaaagctg gacgccgagt gacacaacaa 2722981 tggctagaac cgcgatacca atactttttc tcgtatatgg cgatgcttct gcacctgaaa 2723041 tgtcttttgt ttcatattgt ttcggtttac ggtatacgat cactgataaa ataaggccga 2723101 caaccatacc tgcaactgga ataatcagtg cgtacggaat atcagcaagc ggaacgttta 2723161 acccggcatc cgccatattg tccttcagca tgccttggaa gatttggccg aaaccgaccg 2723221 gaagcaaaat ataaggagcc gttaagccaa atgtaattac acacgcgatc agacggcggt 2723281 ccatttcaag ttcattaaag attttcaaaa gcggcggaat cagcaccggg ataaacgcga 2723341 tgtgaaccgg aacgacgttt tgcgaaaaac aagatacaat taaaataatc agcacaatca 2723401 gcaccttaga cagtgctttt tttcgagaat cttctttatt tccgattaat ttaacggagg 2723461 cttccaccat tgcgtccgga agacccgttt tcgtcaaagc ggcggcaaac gcgccaagca 2723521 tggcatagct aactgcaacg gtggcatttc cgccgagacc gtctgtgaaa gctttaaccg 2723581 tttcgccaag accgagcccg cctgttaacc cgccggccaa ggcgcctata attaatgcga 2723641 taacaatatt gacacgcagc aggcttaata caagcataag caggactgcg atgacgactg 2723701 cattcatgat gatacccctc caaaaatcct ttagtttgct aatgtagtag ataaataaag 2723761 tacgaacgta tcgtatcata accgatccac tttagtcaac taaagatttc ggaagaaaaa 2723821 atccctgccg catcatacag cagggatttt tcattactcg tttttatctt cttccaatgt 2723881 aaatcgctcc gcaagtgtag ccagtgttct tgccataacg ccagtagccc cggccggtcc 2723941 gaagcaggtt gctttattgg cagtcgctgt gcctgcaata tcaaggtgaa cccaaggtgt 2724001 tgactcagcg aattcaccaa gaaacgttcc tgccataatc gcatgtccct cgcgtcccgg 2724061 tgaattgctg agatccgcca tttggctgct tttcacgcgt tttttatcct tctctgttat 2724121 cggcagctgc cagatcgcct cgccgcactc ttgtgcagca tcagctacct gctggtaaaa 2724181 gctttgatca tttgtcattg caccggttgt ttctgttcct aatgccacaa cgacgccgcc 2724241 ggtaagcgta gctacatcga caagaactga tgcgccatgc tgtttcgcgt atgtaatgcc 2724301 atctgcaagc actagccttc cttcagcatc cgtattaagg atttctattg tttttccgct 2724361 taaagatacg atcacgtcat ccggcttcat ggccccgccg gagatcatat tatcggttga 2724421 tggaataacg cacagcacgt tttgttcagg acgaagctct ccgatcgttt ccatagcccc 2724481 gagaaccgca gctgctcctc ccatatctga tttcatgcca acaattccag atttcgtttt 2724541 aatggagtag ccgcctgtgt caaaggtaat tcctttcccg actagtccga cgacgtcttc 2724601 ccattccttt ttgccctgat atttcaacac aatcattttc ggcggttcgg tggagccttg 2724661 gtttaccgca agtattccgc ccataccgag ctcttccatc tctgatttct ccaatatctc 2724721 acactcaaaa tcatatttcg ccgcaagctc ttcagcatac gaagcgaggt cagtcgctgt 2724781 cagcatgttt cccggcatat tcacaagcgt tctagccgaa tttgtccctt gtccgtatgc 2724841 ctggccgacg cgaagccctg cctgcacttc ctgtgtatct tcatctgtta caacatacac 2724901 ggcttcaatt tgtttgtcag gctcatttga tttatgctta taatcctgca cctcatagga 2724961 agcaagcagg cagctctcag ctaaagcatg agcggcatcg gctggaggca cgtcttccga 2725021 aataaacgta tcaagcagaa cagcagtttc ttgttttcga tctttatgaa tggcttgaaa 2725081 aacatgagca aaacgttcct tcgcctgttc aaacgaataa tttgcttctc tccccaggcc 2725141 aacgaaataa atccgtttca tacccgcaga agatggaggg aatacttttg atacttgatt 2725201 cggtttcgca gagacatcac cctcttttaa aagctgtgtc agatggcctt cgagcatttc 2725261 atcaatttcc aacgcttttc ctgtcagctg gcttttttga aaaagcccga caacaagggt 2725321 ttctgtatgc tctgattgtt gaaccgcata aaacatgagg cttacactcc taacgtaatg 2725381 ggtatttgta atgaacaatg gtataatagg aaaaacattc tttccactat acttatttta 2725441 acaaacaaca gtctaagact tgcttttttc ttttgaaaca cgaaggattt ttcaaataga 2725501 aaggatgtcg ccgatggaac ttttaacgaa ttttccttta ttatcaagcc tggccgcaat 2725561 tatttttgct caggtcatca aagtgcccat acagtttatc gtgtccagaa aactggactg 2725621 gtcgctggtc acaagcacag gcggcatgcc tagctctcac tccgcagcgg tcactgcgct 2725681 ttctacaggc gtagccttgg agcatggatt agactcctca ctctttgcgg tttccgccat 2725741 tttcgccgtc ataaccatgt ttgacgcaac tggcgtcaga cgtcacgccg gtgagcaggc 2725801 aacagtcatt aataagcttg ttattgattt taaccgtttc gtaaatgaag cgaaggactt 2725861 ccctaaggct gcagagaaag aaaagcaaaa aaagctgaaa gagcttctcg gacatcagcc 2725921 gatcgaagtc tttttcggag gattaacagg tattttactg acattggtac tcgcttactt 2725981 tttcatgtaa aaaaaacgct cctgctttcg ctggagcgtt ttattctttc accgttttat 2726041 attgatttct gaacacttgc aaagattttg tttcattgag cttctcaagc tcatcctcgg 2726101 taatctttcc cgttcccttt ttaatcacat atacatcaag ggtttttttg ccccattcat 2726161 tgtatacatc tttgactgtc tcaaagtaca gatcaaggcg gtttccctta atagctgatc 2726221 ctgtgtcggc cacaactccg agaccgtagt tcggaatgaa taaaattgtt ccgatcggga 2726281 aaacggacgg gtcagcagca accgtggaat ataaatcccg tttcactttc acacctgaat 2726341 atgtaagccc gtataatgga tcaccgggat ttttgcccgt cgactcagct cctgctgtgt 2726401 agcctgttgc tgttactctt tggactggat attcatccca atcaaatgcc tcttctaacg 2726461 gttttgtttt atcctcagcc gcggacgtgg tttgtgtttg tttctgctgc aatgctttta 2726521 atctcagtcc tgcatgcttc aagtgctttt cctgatgttc ctgcacccat tttgacaagt 2726581 ccttcgcttc aattcctgac actgataaaa atgtcgtgcc aaatgcaagc agaaataaac 2726641 aggtcatcag caaacgtctg atcatattca acatcattca cctctcctcc gaatcattgt 2726701 tcccaagtgg agagagcatt attcaaaatg gtgaatgagc tgaacgcata aaaaaagctt 2726761 tctttagaag aaagcggcat ttaaaacatt tgatatcctc tttttctaag catgttgatc 2726821 gctataccgg acacgatggc gccggccaaa ccgctgacta aaatcagcac atcagcagcc 2726881 gctaatgata agacacgatg aaacaggctg gcaaaggatt ctcccggcga ctggacatag 2726941 ctgatcagct tttctttgct gataatgaaa aggcatacaa ttggataaat cacagccata 2727001 atccaagaca ttctcagcag catgtttaat aagaaaccga ttccaaaaaa caagacaaaa 2727061 aacaaaacaa ttgagatgat tacgactggc agactaatca acctattcca cccccctgcg 2727121 ttgtttttag tgtaacgcgg gggctgaaat aaagtcaacg gctggaaaaa gaatgactgt 2727181 cttttcctgt cccctggcaa gacggacaag tctctgaacc gccgagaatc aattgaaaat 2727241 atcctttccc tgaacaaaat gggcatgcat gtgaagcggt tgtcgttgca gttttcatct 2727301 aatcatcacc ctttttctta attttctgat aatataccat atcaagctgt caacaataaa 2727361 gtcagatcat gtgacaaatc ttttgatgta agcggaaaca tacttgtttt cctctcgttc 2727421 tctttttatt ttggcgtttt ttaataaaga aaacccgctt ccgcgggttt ttagaaaaac 2727481 ttgaacttgc cttttttcaa tgtcagtccg agtccgccaa tcataaacag tgagcggtta 2727541 tcaatgactt ttttcataaa cgaagcgggc gtgcctttca gctttctgcc ataaacaacc 2727601 ccaaccgcgt tatgctcgcc aagagaagcc actgttccct taatgtccgg cttgaattcc 2727661 tcaagctctc cgcctttaat aagcctgcca aggtttttag cgaccgttat gccctgctgc 2727721 attgcaattt gcgcagtcgg cggatacggg cgctctgtat cttcattcat aaacagcgag 2727781 ctgtcgccga gaataaagac attgtcatgt cccggggcgc ggagatcagg gttgactttg 2727841 actcggccgc gcatattctc aaaaccggct tcctccacaa tcggatggcc gcggacacct 2727901 gccgcccata caacggtttg cgatttgatc tgctctggtt cttcatcttt tttgccgact 2727961 ctgactcctt ctggtgtaca ttcttgtaca gccgttccga tcttgaactc aactccgttt 2728021 tcctcaagat aatgtacggc gtaatcaaca agttccggat caaagcccgg caaaacggtc 2728081 ggcgctgctt ccacacaaat gatgcggaca aggcttctgt caacgtcata ttccttacag 2728141 agctccggca cgcgagcagc cagttcgcca agaaattcaa ttcccgtaaa tccggcaccg 2728201 ccaacaacga tcgttaacct gtccggccgt ttttccgctt ccgtattgta agtcgcaaac 2728261 tgcagctcaa tatgttcccg cagcaggcgc gacgtgttga tgttggcaat cggaaacgca 2728321 tattctttta agcctttaat gccgaacgtt tcaggcacgg cgccgagccc gatgactaaa 2728381 taatcgtact gcaattctcc attcgcaagc acaacttttt tctcatcaat tttgattgcc 2728441 tttacggtat cctgtacaaa attcacccgt gactggttga ttacatcttt tatctgataa 2728501 cggcagcggt catgatggag cgtacccgcg ctcgcttcat gcatccatgt cgtttcataa 2728561 tgataattgt gtttatttac aagcgtaatg tcagcatcat tcggcccgac atacttcgtc 2728621 agccttgtca ccgtcatcaa tccgccatat cctgcaccta aaatcacgat tttgggctta 2728681 ttcaatgcca tcacatccac cttctctttt tttgcttttg ttagacccat aataaaatca 2728741 tcatttgtgt tagcttcagc ttattggcgg gattttatga aatatattga aaagtttttt 2728801 gtgaagtcct tacccgtagc actattatca tgtttatccg gctggcccaa gaaacattca 2728861 gaaaaagatc atttcatttg gttattatcg tagcggcctg cggaaatatt ttcaagaacg 2728921 gatgggcacg ttagatcctt acgatttttt ctgctgactc gtcaatttga acggcaatat 2728981 ggtataatta ataacaattt tcatttagga ggcaattttc gtatgcgaga ggatacaaag 2729041 gtttatgata ttacaattat aggcggggga ccggtcggct tattcaccgc tttttacggc 2729101 gggatgagac aggcaagcgt caaaattatc gaaagcctgc ctcagctcgg cggacagctt 2729161 agcgccctat accctgagaa gtatatatat gatgtagcgg gattcccgaa aatccgcgcg 2729221 caagagctta tcaataacct aaaagagcaa atggcgaaat tcgaccaaac catttgtctg 2729281 gagcaagcgg ttgaatctgt tgagaaacaa gcggacggcg tgtttaagct tgtaacaaat 2729341 gaagaaaccc actactctaa aacggtcatc ataactgcag gaaacggcgc attcaaaccg 2729401 agaaagctgg aacttgaaaa tgccgagcag tatgaaggca aaaacctcca ttacttcgtt 2729461 gatgatctgc aaaaattcgc cggcagacgc gttgcgatcc ttggcggtgg agattccgcg 2729521 gttgactggg cgcttatgct tgagccaatc gcaaaagaag tatcgatcat tcaccgccgc 2729581 gacaagttcc gagcgcacga gcacagtgtg gaaaaccttc atgcgtcgaa ggttaatgtc 2729641 ctgacaccat tcgtccctgc ggagctgatc ggcgaagaca aaatcgaaca gctagtgctt 2729701 gaagaagtga aaggcgaccg caaagagatt ttagaaattg atgacttaat cgtcaactac 2729761 ggtttcgttt catctcttgg accgatcaaa aactggggcc tggacatcga gaaaaattcc 2729821 attgtcgtga aatcaacaat ggaaacaaat atcgaaggct tctttgcagc aggtgacatt 2729881 tgtacatacg aaggaaaagt caacctgatt gccagcggct tcggcgaggc accgacagca 2729941 gtgaacaacg ccaaggctta catggacccg aaagcccgcg tacagcctct tcactcaaca 2730001 agtctttttg aaaataaata ataaaaaaag gagcttgtgt ctgcgacaca gctccttttt 2730061 tatttgaaga tatttatata attcaatgca gttcctacaa ccagcgcaat cacaagggct 2730121 gcgactaccc agatcattgc cataataatg cggtcctgaa tcttttggga cttcggtgtt 2730181 ttttcttcgt tttgggccat cttattcgct cctttcccat gtccatgcca taaagaaagc 2730241 ctggtgctga acgaccaagc tttgctgaac gtatatcatt cgcgttttga tccgctctct 2730301 aagaccattc gttaaaacta tgatacctaa actcaccctg catgacaagc ttcggcactt 2730361 gcaccacacc tgccagcaaa tcataatgtt tgacatccta aataaaacag agtacattat 2730421 ataaggcgaa catttcatat attatacttt taaatattcg tttttaggag tgaaaaccat 2730481 ggaaaacgta tttgattacg aagatattca gctaattcct gcaaaatgca ttgtgaatag 2730541 ccgttcagaa tgtgatacat ccgtacgttt aggcggacat acatttaaat tgcccgtcgt 2730601 ccctgccaat atgcagacga ttatagatga aaaactagcg atttcattag ccgaaaatgg 2730661 ctacttttat gtgatgcacc gatttgagcc tgagacacga attgatttta ttaaagatat 2730721 gaacgcacgc gggttattct cttctatcag cgtgggcgtc aaagatgagg agtatgaatt 2730781 tgtccgccag ctggcagaag aaaatctgac tcctgaatac gtgacaattg acattgctca 2730841 cgggcactca aatgctgtca ttgaaatgat ccagcacctt aaaaaacatt tgccggacag 2730901 ctttgttatt gctggcaatg tcggaacgcc ggaagcggtc agagagcttg aaaatgcggg 2730961 agcggatgcc actaaagtcg gcatcggacc gggaaaagta tgtattacga aaatcaaaac 2731021 aggcttcggc acaggcggct ggcaattagc agcgctgcgc tggtgtgcca aggctgccag 2731081 caaaccgatt atcgcggatg gcggcatccg cacccatggc gacatcgcaa aatcaatccg 2731141 attcggcgca acgatggtca tgatcggttc actatttgcc ggacacgaag aatcgccagg 2731201 ccaaacgatc gaaaaagacg gaaagcttta caaggagtac ttcggctcag cctctgaatt 2731261 ccaaaaaggc gaaaagaaaa atgtcgaagg caaaaaaatg cacgtggcgc ataaaggctc 2731321 aatcaaggat acactgattg aaatggagca ggatcttcaa tcttctattt cttatgcagg 2731381 cggaacaaag cttaacgcca tccgcaatgt ggattatgtg attgtgaaga attccatttt 2731441 taatggggat aaatattaat cataaaaaaa cgccaagtca gcggttctcc gcttgagttg 2731501 gcgttttctg ctacttcttc agcaaagtaa gcttatattt gctttttgag tttatcttcc 2731561 atcagttctg ccatttgttt tgcatttgga ttttcttcat tttgcaactg ttcaatgacg 2731621 ttcatataat ccgtttcatt tcggttctgg cttaatttat atgccgcttg aatgtcttcc 2731681 accttaatct taaatccaac aatacctttc aattcacttt ctaagagttt tggagaaagc 2731741 ttatcccata acacaggatt gtcacgatgt ttttcgtatt tctccaacat gattgttaat 2731801 tcttctgcta attcatcttt ctctaacata cttgcttttc catacatgtg gacagcctga 2731861 taattccacg tcggaacatt ttcgcgcgaa taccaggaag aagaaatata agcgtgcggt 2731921 ccctgaaaca tcacaagcac atcttcacag gcttcaaacg ttctccactg aggatttcca 2731981 taagcgaaat gccccgtaat atagtaatga tcgtcttttt tattgaatcc taacggcaaa 2732041 tgtgtggcaa ttggttttcc ttgttctgtt gtgacaaccg taccaaagga gttttcttgt 2732101 acaaaattcc aaatttcttc agcatttgtg actttaaaat attttggaat atacatcatc 2732161 atccaccctt cgaaaaatat tatatgagtg ttttagccat gattaaatcc gtttgttctt 2732221 catcacccat ataaaatgag tgggcgccgg tctgaacaaa ccccattttc ttataaaagg 2732281 caatggcatt ttcatttttt tcccacacac ctagccaaat gttcttttta ttacgttcca 2732341 gcgcaatttc tatcgcttta ttcagcagat gtttgccaag cccatgtttt tgaaagctgt 2732401 tctttatata aattctctcg atttcaagtg attcagcacc catttcttca gactgagcat 2732461 catcgatatt gacctttaca tatccagcga tttcatgatc aaagtaaata aaaaagaatt 2732521 gcgaagacat attagataac tctttttcca gctgctcagt gttaaatgcg ctttctaaat 2732581 aggctttcat attttcaggt gagttctgtt ctttaaaagt gtcattgaat gtttcaatac 2732641 tcaattgttg aagtgtttgt aaatcttccc ggctgcattt tttcattttt acactcattg 2732701 ttcggattca gcccctttat ttaaaattca attgtcttgt gtccctttta tatatttaaa 2732761 cacggaacac atactgacct tgttaccatt ccaaaaatct tcttcatcac caactcccta 2732821 tcgtgatttt gttgtaaatg caataaaata tactccgcat taaatatatc gtaactttgc 2732881 tgtatttaca acaaaaatca aacaacaaag cagcgtttct cttgccgaag ttcccggaac 2732941 tctctgcatc atttccccat aataaaaacg cctcccttaa cgatgattta tcgctaagaa 2733001 aagcgtcagt aatagttgct atccgttttt agtgcttagc actcttcagg cttgcctgca 2733061 ttcgttgctg ttctgaacga agaaccgcag ccgcatgaag cgatggcgtt tggattgtcg 2733121 atggtgaagc cgccgccgag catggattgt ttataatcaa tcacggtgcc gttcatgatg 2733181 tcaaggcttt ctttgtcaac tagaacagtg atgccgtgct gatcaaacac actgtctgat 2733241 tcactctttt catgctcaaa gcccatgccg taagaaagtc cgctgcagcc gccgcctttg 2733301 acgcctacac gcagaaacgc gttttcttct tcatgctctt tcatcatatc ttttatatgc 2733361 aaagctgctg cttctgtaat tgttaccggg ttgctcatca ttatgaacct ccttttaaaa 2733421 accggttgct gtcttttatt ataaacatga tcgttccaat tctcaaacaa ggtgttttac 2733481 aagaaataga caccctcaca aacggtttca gccggccctg tcatcattac atggccgtta 2733541 tctttccagt ttatcaccaa atccccgcct gctaaatgca ccgtgatgtc ttgatttcgc 2733601 tttgatacgc cgtttaatac agatgcgact gccgctgcac atgctcctgt cccgcatgcc 2733661 tgagtaatcc ctgatccccg ttcccagacg cggaaatgca attcttgttc attcacggtt 2733721 tcaacgaatt ccacattgat gccttccgga aatctcggat ctttctcaat caccggcccc 2733781 agtgtcgtta agggtgcctg ttcaatgtct gcgatcggaa aaacgatatg cggatttccc 2733841 attgaaacgg cagtgcctgt tagttctact tcaccaaatg ccatcgtttc attgattgtg 2733901 tgctcttccc cgccgtcaag cataggaagc tcggattttg tcaagcgcgg ttcgcccata 2733961 tcgacagtga ccacattcac ttttccgttt tcgacttgaa cctccgcttt cacaagcccg 2734021 gagagagttt caatcagaaa agatgtttcc tcaaccagct tatgctcata tgcgtatttt 2734081 gcgacgcagc gcaggccgtt gccgcagttt ttcccttcag acccgtcatt attaaaaatc 2734141 cgcattttaa caggcgcttg gtctgatggg catatcagga tcattccgtc ggatccgatc 2734201 cctgtataaa cagaagaaac ctgaattgca atctctgaca gtttttcttc tggaagctgt 2734261 tcttcaaatt gattcacata aatataactg tttcccaggc cgtgcatttt ggtaaatcga 2734321 aatgagttca taggtgcctc caactttttt tctttttctt agtataaaag ctattataag 2734381 cggacacaat acaattatcc cccgtttttc atacataaaa gctccttgca ctgacgcaag 2734441 gagcttttat cgtttatata aacatgccgg caatggctgc gctgagcaga ttggctaatg 2734501 ttcctgcaag aacagccttc aggccgagac gtgcgatatc tgaacggcgg ctgggcgcta 2734561 aaccgccaag cgtaccaagc ataatcgcaa ttgatgaaaa attggcgaat ccgcataacg 2734621 cgaaactgat aatggtagca gttttcttag aaaactcgcc gatgtgcgaa ccgaagttag 2734681 aataagcgac aaactcattc agcaccaatt tctggccgat atagcttccc gcctgcaatg 2734741 cttcatgcca aggcacgcca atcaaaaagg cgataggaga aaacacatag ccgagaatgg 2734801 attctaatgt tacgcctttt aaaccgaaca agccgaaagc cccgccgaga ataccgttta 2734861 ctacagcgat taacgcaaca aacgcaagca gcatcgcccc aacatttaac gcaatttgca 2734921 gtcctgttga cgctcccttt gcagctgcgt caatgacatt ggctgcgcct tcgccttcat 2734981 ccattttgaa atcgcttttt acggtttgcg ttttttccgt ttcgggtata atcaatttac 2735041 caaagactag tccagctgga gcagccataa agctggccgc cagcaagtac tcaatcggaa 2735101 taccgagaag cgcgtaccca aacaaggtag atcccgcaac tgccgataga ccgctcgtca 2735161 taatcgtaaa caactcagag cgcgtcagcc cggcaatcag gggtttgatc actaacggag 2735221 attctgattg tcctacaaaa atattggcag cagccgccag agattccgtt ttgcttgttc 2735281 caaggagctt cgacaatccg ccgccaatga cacggaaaac gagctgcatg attttcaaat 2735341 gatataaaac tgcaatcagt gctgagaaga aaatgataac gggcagtaca cttaatgcaa 2735401 atgccggact gtctccgacc tttagaagcg gtccaaaaat aaaactgatg ccttcattcg 2735461 catagtcaat cagaagctgt acacggcttg aaaaccataa aaaaacagcg cgtcccgctt 2735521 cccatttcaa cacgatgtat ccaaacgcca cctgtgtgca taaaccaacg atgacggttc 2735581 ttatcttaat attgcttttc ttttctgaaa ataaaaacgc gatagcaatg atcgcaactg 2735641 cgcccagcag cccccacaga acattcatga atactcgtac acctcttaaa ttttatttaa 2735701 aaaaatatct tttatacgat aacaataata ttttttgatg tctacacatt tttttagttc 2735761 ttttgtacgg caaaataaaa aagggcctgt ccaggccctt ttctttaaaa cattggattt 2735821 tcttcaataa aggtatatat attctcaaca agctcagcag gcgtttcacc catgacgact 2735881 tctccgttta ccagagcgaa aagcgattcc atacatgtcc cgcagtagct taagcagcca 2735941 tattcaagga catcaaggtt gggatccttc tccaaaatcg cccgggcttc ctgagagccg 2736001 tgagccagat tgctgacaca aaattcaatc attggattca tgcggtttca cctcacatat 2736061 gtccattatc gcgaattttt cactattcgt caaagacaac ggatgattca aaatttatta 2736121 tcgtaacata ttatttctca aataacgttt tactaatttg tgttttcagg ctaaattgta 2736181 ggttattttg aaactattat tgtgatttta gatcaaattc gatataattc tagatgttat 2736241 tttacatagt tcgtattttc ttcaatgtat ctatcatact cttcggatta aaggggaatt 2736301 caaatgaaaa aattggtctt gatcggcgga ggttacggga acatgcgcgt tcttcatcgc 2736361 ttattgccaa accagctgcc tgatgatgtt tcaatcacgt taattgacag aaatccttat 2736421 cactgcttga aaacagaata ttatgccctt gccgcaggca caatttctga ccatcatatc 2736481 agagtgtcat tcccagagca ccctcgcctg gatgtccaat acggtgatat cacatcaatt 2736541 gatattgtac aaaaacaagt gctgttccaa gatcgtgaac cgatttctta cgatgacgcc 2736601 ataatcgggc tcggctgtga ggataaatat cacaacgtgc cgggagcgcc tgaattcacc 2736661 tacagtattc aaaccatcga tcagtcccgc gaaacctacc aaaagctgaa taatctgagc 2736721 gctaatgcca ccgtcgccat tgtcggagcg ggcttaagcg gcgttgagct tgcaagtgaa 2736781 ttgagagaaa gccgtgatga cctgaacatt attttgttcg accgcggtaa tctcatttta 2736841 tcaagctttc ccgagcgttt aagcaaatat gtgcaaaaat ggttcgaaga gcacggtgtc 2736901 cgcattatta acagggcaaa tatcacaaaa gtagaagaag gcgttgtgta taaccacgat 2736961 gatccgattt ctgcagacgc catcgtgtgg acagccggca tccagccaaa caaagtcgtc 2737021 agagacttag atgtggagaa ggacgcacaa gggcgtattg tattaacgcc tcatcataat 2737081 cttccaggtg atgaacatct gtacgttgtc ggcgattgcg ccagtcttcc tcatgcaccg 2737141 agcgcccagc tggcagaggc tcaagcagag cagattgtcc aaatcttgca aaaacgctgg 2737201 aatggagaag ccctgcctga atcaatgccg cagtttaagc tgaaaggcgt cctcggttca 2737261 ctcggaaaaa aagccggctt cgggcttgtt gctgaccgtc cgctgatcgg ccgtgttccg 2737321 cgtatgctga aatccggctt gctgtggatg tataaacacc ataacggtta atgatagaga 2737381 agaaccgctg atcaagtcag cggttttctg tatacccatg cttctccatt tcctcataaa 2737441 cgtcttttaa ttttggattg ccttcaccga caattttgtc ttctacaagc acaagcggat 2737501 aaaaatactc gtcatttctg attttttccg caagctcttt cgcatgttca ttgtcaggcg 2737561 gctcatgaat atcgatgtac tgcatctcaa aaggctgatt tggatatttt cttttcagcg 2737621 cagcctcaag ccactcgtat gtatccttgg ctgtcggcat atttacacag ctcgcacaaa 2737681 cgttttctgc cccgtacacg cttagcatga ctggtttcat cacttgtaga cgcccccttc 2737741 tcctatgtaa gtcctttctt ttaagtatac agagcctaag ggcgttttta tagaaaaaaa 2737801 ccgtttttgt gttgaagtct gaatgtgcta taatagggaa agcaactttg caaaccaaac 2737861 aatagatttt tattgttaca ctgaatataa tggttttatg acgacgaaag gagcgaatgt 2737921 catgactgaa gttgaaatga aagaacaggt gcaggaagta ctggacaaac ttcgtccgtt 2737981 tttacttcgt gacggcggtg actgtgagct tgtagacgta gatgaaggta tcgttaagct 2738041 tcgtcttcta ggcgcatgcg gcagctgccc aagttcaaca attacgttga aagccggaat 2738101 tgagcgcgct cttcttgaag aagtgccggg tgtcgttgaa gtagaacaag tcttttaata 2738161 aagcagccag gctgatattt gatcagcctg gcttttttat tagagatgtt gatcaaacca 2738221 tgagctgata taattcaggc gcttgatccg ctgtcttggg tgtccggtgc gtgataaatt 2738281 gtgcgatgca ttcggaaaac ggacaagctt ggtttccttg cccatttttt tcagagcgat 2738341 aaacagctgc tccgcctgct cgatcgggca tcggtcatcc cgctcgccat gcagtatcaa 2738401 aagcggtgtc tccacgtttg ctgcgtattt taaaggagac cggtcccaga gcttttctgt 2738461 gtcctcaaac atgtcatgct caagctgcca gtctgtaaag aaatagccga tatcactgac 2738521 gccgtgaaag ctgatccaat ttgatatcga gcgctgggta acggcagctt taaagcggtt 2738581 cgtctgcccg acgatccagt tggtcataaa acctccgtag cttccgcccg tgacaccgag 2738641 ccgcttagga tcaatatgcg gatctcgttt gatagcctca tccacagcct gcatcacatc 2738701 gtcataatcc tttcccccat aatctcctct gaccgcattc acaaattcct gcccgtagcc 2738761 gtggcttcct ctcggattga tataaacgac cgcgtatcct ttcgccgcca gcacctgaaa 2738821 ctcatgaaaa tatgtatgtc cgtacatcat atgcggaccg ccgtgtatgt taagaataag 2738881 tggatatgtt gtctcacctt ccatttgtgc aggcctcatc agccagccgt tcaccatcac 2738941 gccgtcttct gtagcatatt gaatctcttc aggtattgat atcgtatgct ccctgacaaa 2739001 cttgtcattc gcgccagtca gctgtttctc ttcctgtcca agcgggatac tgtaaagctc 2739061 actcggtctg tccggctttg tcacactggc aataaagtgc tgttcatcag gtgaaagaga 2739121 aaagctattg atgtactctt tttccagacg aatcggatac acaaggcctt caatcgaaat 2739181 ataatagatg cccgtactgc cttgatctgt gccgatgaca taaaaccctt ggctgtcctt 2739241 tgtccaaatc gggcgctgtt cagcaccacc gatcaatgaa tctccaatca gcgcatccgc 2739301 taaatgaacg tccagcatct cagtaagaca tgtgaggcgg ccttgttcga tatcatagag 2739361 ccacgccttt gagagcgtag cattcttata ttccttttca tttccaagca aagcaagata 2739421 ccttccgtct ggtgaaaatg agcttgatcc gaatgagccg cgatgaggtg taacctgctt 2739481 aagatctcca gactccagtg acattatgta aacatcatgc ggcttgctgg catcatctgt 2739541 ttcagttaaa ttagctgaga aaacaagcca tttgccgtca ggagaaaaag caggatcacc 2739601 atgatcagct ttgtgacttg tcagctcttt catctcaccc gactttacgc tgacaagcac 2739661 aagctgggca tacgcacctc tcgtcagccc tttgccgtcc cgtttgtagg agaggccttg 2739721 cacttcaaca ggttcatagc tgtcctgctc tgttttttct cggtcatcaa tgctttcccc 2739781 ctctcccaaa ctgacagtga ccagaatcga ttcaccgtcc ggggaccata gcggctttga 2739841 cacgccatat gggatatcag tcagttttct tgcttctccg ccttcagtgc tcatgatata 2739901 aagctgtgcc gcatcgcctt ctcgatcaga aataaaggca agcgtgcgcc cgtccggaga 2739961 ccatcttggg tcggtgcttc gcttttctcc atgtgtccaa ggaacagatc ctcccgtttt 2740021 cgtttcatag atccatatat ttgatgtata cgaatctttc tcttgattta cttgtgattt 2740081 tacatatgcg gcacgggtac cgtctggggc gtattgagga tcggtcacag agacaatcgc 2740141 tgtgatgtcg tctgcggtta tcagcttttt catattcatc tcctcctttt tacatgtatt 2740201 tcgtttttct aaataaaaac tcctttatct ccagcaaaaa aaagcgccct ccgctgacgc 2740261 tgaggaacgc ttggcatgat ctatacactt tttacttgat ataaaggatt tcgctctatt 2740321 atacttccct ctttcggaac ggtcaaagcg tctacttcac aatgagggaa atgaagcgcg 2740381 agctgttctt ttagctcttc tccctttcct ttttcggtca tgacgagaat cgttgggcct 2740441 gctccgctga gagccgttcc atatgcgccc ttcatctcgg cgacgtgctc tacttttgac 2740501 agctcaggca caagcatcgc ccggtacggc tgatggaaca tatccttctt catgattttc 2740561 ccgacaagcg gccaatcctt ggacatgatc gcagcaatga ggatattgct gacagcactt 2740621 gcttttacgg catcggcata tggaaactcc ttcggaagca cgtctctcgc gtctcttgtc 2740681 agcacttcat aaaaaggaat gacaacgact acgtcaatgt cagcattcgg gacgcggatc 2740741 atttgggtct cgtcatcctc atgcaggccg atcacaagtc cgccgacgag agaagcgcca 2740801 gcattgtccg ggtgtccttc ttctagactc gctaaatgca gcttgtccgc ttcagacagc 2740861 tttaagccgc ataattcatc agccagttca atggccgcta caatcgctgc ggcgctgctg 2740921 ccaaggccgc gtgcaagcgg gatgtcgctc cacaccttca catggacagg aggcatttct 2740981 tttccgtaca aatctgcggt ccgtttagcc acttggtaga tcaggttatc tgtacccgcc 2741041 ggaattccgg cgactgtttc tgtttcagcc tcaaaagacc atttgtcgct ttcaaagacg 2741101 gtcagcttca aatatctgct gagcgccatt ccgactgaat caaagccggg gcctaggtta 2741161 gctgtgcttc cgggaacagt gacagagaac agcatgtcgg cttcgttcat acacgggccg 2741221 ctccttttac atattcaagg atgctgtctt catcagtcgg caatgtgaca ggcttgattt 2741281 ctgaaatgtc gaccgctgtg ttcggatctt tcagtccgtt tcctgttaac acagctacga 2741341 ccttgctgcc tttcggaatt tctccggatt tcacctgttt cagcactcct gcgatagacg 2741401 cgcaagaacc tggttctgca aacacgcctt ctacacgggc gatcagctga tatgcgtgaa 2741461 ggatttcatc atcagtgact tcgtcaattt tcccattgga ttcctcggct gcctttacag 2741521 ctttgtccca gcttgccggg tttccgatac gaatggctgt cgctattgtt tccggatttt 2741581 caatcacttc attgcgcacg attgccgccg caccctcagc ttcaaagccg cgcattttcg 2741641 gaaggcctgt gccgtttttc tcatgatatt ccttgaagcc cttccagtac gcagtgatgt 2741701 ttccagcatt tccgaccggg atcgctaaaa catcaggcgc ttcccccagc tgttcgcaca 2741761 cttcgaaggc agcagttttt tggccttcaa tgcggtaagg gttgactgag ttgacaaggg 2741821 caatcggtga tttctcacag atggaacgga caattttaag cgcatcgtca aagtttccgt 2741881 caattgcgat aatctcggct ccgtacatga cagcttgagc gagttttcca aatgcaattt 2741941 ttccgttcgg gatgatgaca atgcatttca tgttagcacg ggctgcatat gctgccgcag 2742001 cagcggaagt gttacctgtt gacgcgcaca taatcgtgtc attgccttct tcttttgcct 2742061 ttgccacagc cataaccatt ccgcgatctt taaatgatcc cgtaggattg acgccttccg 2742121 ttttgacatg aagctcaatt ccgagctgct cagacagctt cggcaggtga ataagaggtg 2742181 tgtttccttc atgtaaagtt agcgccggtg tttgatctgt tacaggtaaa aattctttat 2742241 attgatggat aagtcctttc cacattagct ccaaccgttc ccttctacac gatatgtgct 2742301 tttgacttct tgaacgactt ccaaatcatt taggttttgc aggatatcac tgaaatcagc 2742361 ttctgatgta tgatgtgtga caattacgat ttcagctaac tcatcatggc ctttaattgg 2742421 cagctgaagg attttttcaa agctcacgcc ccgctctgag aacacagatg taattttcga 2742481 gaatgaacca acctcatctt ttacatgaat tcttaaaaac tgctgtgcat aaatgtcaga 2742541 cggcgatttc atgtttttct catattgcgg tccgacaaag ctgttgccgg ttacacctag 2742601 gcgcatattt ttcatgacag cgacgaggtc agaaacaacg gatgtcgctg tcggcatgct 2742661 tccggctccc ggcccgtaga acatcgtctc accgacagcc tcgccgtata cataaacagc 2742721 gttaaactca ttatgaacag cagaaagcgg atgatggtca ggaagcagtg tcggctgtac 2742781 gctgacctcg attttgctgc cgtcacgctg agcaatcccg atcagcttca ttgtatagcc 2742841 gaggcgtttg ctgaagctga tgtcctcgtc tgtaatttgg gagatcccct ttactttgac 2742901 gtcttccaga tccacgttca tcgagaagcc gaggcgcgcc aatatcgcca ttttccgtgc 2742961 ggcgtcaagc ccttccacgt cagaagtcgg atcagcttcg gcaaaaccga gatcctgcgc 2743021 ttccttgagc acttcctcgt atgggctttt ctctttgatc attttggtta agataaagtt 2743081 tgttgtgccg ttcacaattc ccatcatttt tgtaattcga tctgatgaga ggccttcctc 2743141 taacgtgcgc agaatcggaa tcccgccggc aacactggct tcaaagtaga tatcgcatcc 2743201 attttccttc gcttcggcaa gcagctcgga gccgtacaca gccattaagt ccttgtttgc 2743261 tgtgacaaca tgctttttcg atctcagcgc gtcgaccaaa tattgttttg tctgttcaac 2743321 gccgccgatc acctcgatga cgacatcaac atctggatca tcaatgacat catacacttc 2743381 tgtcgtgagc acttccttcg gcaaatctac ttctctcttt ttctctaaat cttttacaag 2743441 cacttttttt atcgtaaccg gacagccgac ctgatgcata agcttatcct gatggtcttg 2743501 aataatttta acgacaccgc ttccgacggt acctaaacct aaaagcccta cacgaatcgc 2743561 tttcaaaaaa actccacctt tcttttgatt gtcctcttgg aaaagacaat tgttaactca 2743621 acacagacat ataagttaca aacattatat aagcccgctc ctgttttgac aagacatcat 2743681 taggctgaat tttgcgaatg taaacgctta acgcattgat atgacaagat tctttatttt 2743741 ctaattattt ttgtcagatt ttctcctcac cttgagctgc ctttgccgag ccagctgacg 2743801 cgtggaacaa acagcttctg cgcccgcata ttcatgaatt cctgcgctgt attgagaaat 2743861 tgttcataac gcccacagtc attaagaatg aagtcaagct gttcttcaaa ataatgcttt 2743921 tctgattctg atgacatgta atagctttct acgatttcaa aataatgaag cgggaaaagc 2743981 agacggctgt ataaaaggcg tttcgaaaat gaagacagcg gtgtgacttg ctcgtattcc 2744041 tgtaaaaaga gaaagccctg ctgattaaaa tcttgtctgt gatgcaaaaa cgtatgcctc 2744101 atatattcag ccaaatcacg ggaagcgtgg tcaaacaccc aatccgccgg aatcctgatc 2744161 aatgattccg gtgaccatgt atgcctttcc atccgctgat ggcatatcgt tcctgaatca 2744221 gcggcttggg gcttgtcatc cagctcagtg tccactaaat attgtatcgc gttttctgac 2744281 agtcctaaat aatatggaaa tgattcgatc atttttttat cgaatggctc atgcggaggg 2744341 gtctgaacct ttctctgcca aaatgcttcc agctgatcaa ttcgttttcc ccacagatcc 2744401 ttccactggc cgattcttcc ggccgccttc acctcatatg gatatcctcg gccttttcgg 2744461 tgaaattccg caagctccgc tccaatggag aacgccctgt ttgaataagg gggggccgcc 2744521 ttcagcagag cgtacgtttt tccctcatgt tcaaatgtca gttcaccttc ttttgtaaag 2744581 ataaaaaccg aaacgtatgg gtcactttgt tcttgtaaat actgactcat gtaataaagc 2744641 tccgccagct ctgtttctga gaattgggaa acggggacaa tcagaaagta tgaattaggc 2744701 gtctgaaagc attgatatgt gtgctggtac atggaaagct gcctgatgtg aatgccgtat 2744761 ttttctttta ttgtaccttt caccatgatc acctgcctgt tgaattaggg ctcatcacat 2744821 cgtagtcata cacagccgga attatgaata catattttaa tccgaagaag gcgcaagaaa 2744881 aagtcgtaaa cttctcaagc attttgtata aactagtaaa aaagattggg tgaagctgat 2744941 gtcagaaaac gaacaattca gtcagatgga agctaaagca agagcacgga tgaaggagcg 2745001 cggcgttgag gtatcagaca ttgccgagct tgtctttttt ctgcagaaaa aatatcatcc 2745061 ggatttaacc attgatgaat gcacgctgaa cgtcaatcgt gttctcgcaa aacgcgaggt 2745121 gcaaaacgcg attttaacgg gcattgaatt ggatgttctt gctgagcaga aaaaattgtc 2745181 tgaaccgctg caaacgatgc tggaaataga tgaaagccta tatggagtag atgaagttct 2745241 ggcattttcc attgtgaaca tttacggatc gatcgggttt acgaactacg gttacatcga 2745301 caaagaaaaa cccggaatcc ttaaacgatt gaatgataaa tcaaccggtg aatgccatac 2745361 ctttttagat gacatcgtcg gagcgatttc cgccgcggct tcaagcagac ttgctcaccg 2745421 cgcgcggcat acagaataag ggcacccttt tagggcgccc ttttttcaaa tgtatggaat 2745481 ccattcagtc agagagtcaa tggcgtgagt cggtttttcc atatcgtctg tcatatgttc 2745541 tcttttcgtt acgcctgtgt gaacgagcag cgtatccata cccgcgttaa tgccggccat 2745601 aatatcagtg gcgtagttgt cgccgaccat gagtgtttca gacacatctg tgccgagaac 2745661 gcgcatcgcc tgctccataa taattgattc cggcttgccg ataaatacag gctgtacacc 2745721 tgtagatacg gttaacaccg atgtcagtga gccgtttccc ggcaggagcc ctctttcagt 2745781 cggaatcgca atatctccgt tagtggaaat aaagcgggcg ccatttctga ttgccaggca 2745841 gccaacagca aatttttcgt atgtaatgga acggtcgatg ccaacaacga caaaatccgc 2745901 gttttctccg ccaaatgtca ggccgttttc ttcaatcgcc tggcggattc cttcctcccc 2745961 aatcacatac acagacgcgt cttttttctg ctgtgcaatg tgctgggcag ttgccatgct 2746021 ggtcgtgaag acctgctctt ctgttgccgg aatatcaaaa gacacgagct tgtccgctac 2746081 ctgcttcggt gtgcgcgaag agttgtttgt cacgaaaaga taaggaacgc cgcgatcttt 2746141 cagcgttctg acaaattcac acgcctcctc gattttttcc gtgccattgt acatcgttcc 2746201 gtctaaatca attaaatacc ctttatatgt tttcatatcc aacactcctg tggctttcca 2746261 gttgttattt aaacgcggaa acaggtccta gctctgtttc caaatagctt ctgatccgtt 2746321 tcgggaagtc ctgaagagct gtttgatgcg ccttgatcag cctgtaaagc tcgccgctgt 2746381 cagcgagcag atactgttga accaacgttt tgcggtaggc gatcaatttt ttgagctcat 2746441 caccctcttt ttccgtgaca actttctcat caacaagtat atccataatg tcgtcatagc 2746501 tgcccgggtc ccgcataata aagccgtcaa tcatgtcatt gcctgtatcc aaaatgcatt 2746561 cgattaacag atggcctata cgctgaagtg ccaattcccc gatttcagac tgccagtctg 2746621 tttgtgagtc aaatagcgcc agctggtgct cgaagaaccc tagtgttttt tcgattttgc 2746681 ttctgtcaac aaaatacatg acagcatccc ctttgtgtat atttattttc tgatccgttt 2746741 caagacaaaa tacgcacagc cgaaattgca gtattcgtaa atatattcat ctaatgtgct 2746801 gattttcgtt tcgaaggttg ccttttgatt ctggtcgtca aagaagccct tgagccttaa 2746861 ctgaccgtat ccccagtctc ccacaatata atcgtattta tttaatatat cggagtagcg 2746921 ggctttaaaa gcctcttcgt tgaagccgtc tttgaaattg tgcaccaatt caaattcggc 2746981 attttgaata agaatcatga tctcacctct tttttcactc attcctatca taattcattg 2747041 ccccgtcccc atcaattgct aaagaataaa tcatgcgatt tggctaccct acacatgagg 2747101 agggattgat aaatgaaacg aaccgctgtc agcctctgcc tgctgaccgg actattatcc 2747161 gggtgcggag gcgcaggatt ggataatgcc caaaatgtcc ggaatcagac gcagaatcaa 2747221 accaaaccca ttcatgtgtc ggaccgcaac gaggctttta acaggcataa tgagaacgaa 2747281 caatttggct atgtccgcta tcaaaaagaa caatttgacg gagaacagca gaaaacgccg 2747341 gtgatgaacc gggaagaaac cgctcacatg atatcaagtt taacggttca gctcccccat 2747401 attcaagatg ctgcgacatt ggtgactgac cgagaagcgc ttgtcgtata caaaaccgat 2747461 tctaaaaacc gggagctgac cgccgatcag gtgaaaaaaa cagcggcttc tgtgataccg 2747521 cgatactatc acgtgtatat ttccgataat ccaaaccata tgcaatccgt cgaaaattac 2747581 agcaatctcg gctctggttc aagggatatt agagagatca tgtcggggac gattcaagaa 2747641 atgaaaacct ccccgcaagg aagccctgtc tcagagaatg aaaatgccaa tggagaaacg 2747701 cgtcaggaca tgaaaatcga taggaatgac aaaaacgcca gatgatctgg cgttttggca 2747761 ttatgcttgt gcttgacgct ttttagatgc ttcgtttact tgttcatccg catggtaaga 2747821 ggaacggaca agcggaccgg cttcacaatg gctgaagcct ttttgcatcg cgatttcttt 2747881 taattctgca aattcatcag gatggtagta tttttggact ttcaagtgtt tcttcgtcgg 2747941 ctgcagatat tggccgattg ccataatatc cacgttgttc gccaagaggt cgtccattac 2748001 ttcaataatc tcttcttttg tttcgccgag tccgatcatg atacttgatt ttgtcggaat 2748061 gtcaggctgc atttccttcg cacggcgcaa aaattccaat gaacggtcgt acgtcgcacg 2748121 cgcgcggact cttggcgtca ggcggcgaac cgtttcgata ttgtgattca ggatgtctgg 2748181 gcgtgtatcc atcaaggttt ttaggttatc gtagtttccg cccatatcag acggcagcac 2748241 ctcaattgtt gtgaacgggc tttttctgcg gatcgcacgg acagtttccg cgaaaatgcc 2748301 tgccccgcca tctttctgat cgtcacgcgc aacagccgta atgaccgcgt gtttcaaatt 2748361 cataagcgcg actgaatccg ctacgcgttc cggctcttgc agatcaagct cagttggaag 2748421 gcctgttttg acagcacaga aacggcatgc tcttgtacaa acagaaccta aaatcataaa 2748481 tgtcgctgta cgtctgaccg cccagcattc atgaatattc ggacactttg cttcttcgca 2748541 tacggtatgc aggttgtttt cccgcatgag ttttttgagc cctgtatagt tttcatttgt 2748601 atttaattta attttaagcc attcgggctt tctgaggtgt tcgtctttct ttgccaattc 2748661 ccatcatctc caatatccaa tatactcaat ttctgacacg aaacattctg aaaacgagaa 2748721 aggtgcaggt tttagttctg caacaaaaat aatgtttttc taactaaaga aagtcttttc 2748781 tttagacact ttaacatagg aaaaatttct cgacaaggga agatgattac tgacattttt 2748841 aagccgggtt gccgcaaact atgtgtattc aatatgaaag gagattattt tgtgaaagtt 2748901 ttgttatccg ctcttcttct ccttttgttt gcatttgagc cttctgcgtc tggaaaaaaa 2748961 ctttcagatc cagtgctgtc gaaacggatg gaattatatc ataaaatcga agctgtgacg 2749021 cagatccctt ggtatgcgct cgccgctgtt gatcaatacg aagaaaacgt gcggagcaac 2749081 cggaaagatc tgcctgaaaa ggcgggaatc atcagcatct atatacccga tgatatctgg 2749141 agcgggcctg aaaacccgaa tccgaaagac gatgcgccgt taagcattaa agtgtttgac 2749201 ggaatcggaa tggatggcga tggagacggg aaagccgagg tcagcaacga tgaagatatc 2749261 ttgtatacgt tcagccaata cttactgtcg tatggcacag atgaagacaa catccggatc 2749321 gggctttgga attattaccg gcgtgatcag acagtgggga ttatatctga attcatgaag 2749381 ctgtttaaag cctacggcca tattgatctg ggcgagcatg cattcccgct tccgatcaga 2749441 accgattaca gctaccgaag cacgtgggga gatgcccgcg gcttcggtgg aaggcggatt 2749501 catgaaggta cggatatctt tgcccattac ggccttcctg tcaaatccac atgttacggc 2749561 gtagttgaaa tgaagggctg gaaccgcttc ggaggatgga gaatcggcat cagggacatt 2749621 aacaatacgt atcattattt tgcccatctc aatgggtttg ccaaagggat taaaacagga 2749681 caaatcgttg agcctggcca agtgatcgga tcagtcggca gctccggata cggcccgccg 2749741 ggaaccgccg ggaagttccc gccgcatctg cactatggca tgtacaaaga taacggaaga 2749801 accgaatggt catttgatcc atacccgcat ttgagggcgt gggagcgata tgaataccaa 2749861 aaaaagaagt aacaaaaagc cgcctcttca acaggcggct tatttgctgc ttttttcttt 2749921 ttttgaatcg gcaccgtttt ctttgctgct cggaagctgg acagaaggcg tgacacccga 2749981 gccgccgctt ccattataaa actgcggcac ttcgccctgc actgctttaa tcgatacagg 2750041 aacattattt gtgacgacag cggttttgct ggcaaatgga atgatgacct tcactttaat 2750101 ttcgacaaag atgctgatat caataagtgc gttatttatg ccatacggct tgattttggt 2750161 tttgacatct gtaaaagcgt caccgattaa attgaaccgg accgggattt tcggcccgag 2750221 gtttccaaga aggctgttgc cggttacctg tcccagcgga atgttgatca taatgttttc 2750281 actggcgccg ctgtgtccgg tatgggtttc catctctttc aaatgagcct gaagctgctt 2750341 tgtcactttt gttttcacac tgtttacaac ctgtgtatta aaatcgattg tcgttaagtt 2750401 tccgttttca tcagaattca tttgaaacat atctttcata ttttcactgt cagacatata 2750461 gtcctcaatc gaatcctgga tcacctctgt cgctatacgc ttcgtttcca tctcgccgat 2750521 gtccattaaa acaggtttga tcgagccatt gatcatccaa aggctgaccg ttgttgacag 2750581 gataaaaaag acaacggaca ggagcatcac gtaacggaaa ggcaaaggtc ctctcttgcg 2750641 aaaagggccg cgatatcttg gcaagaaaat ccccccttac atatcacaat gtatgcttgt 2750701 aagaggggac atagtaatag ccggggccaa tttattttat ttcatcattt ttaaaagcgc 2750761 ttctctgccg ctcatgccga ctttgatgcc aagatcttcc gcagcgtacg tgacggattc 2750821 taaaggtgcg tctaacagct ggtcaatggt gcggacacca actgcgcgtc ccgccacgat 2750881 gccgcgctcc tttaattttt cattcagcag cgccacatca agcgcgccgc acataatgta 2750941 tccgtgatca ttggcgacgg ccataaaatt cgttttggga agctttactg tcacagctgt 2751001 aaaaggctgt ccttctatca tgatcggtgt caggtttacc acgtcaacca ctcccttcat 2751061 tcatcacttt atgatgaagg gcacagcttg ttgtgggctg actgccttat tgtgcaagct 2751121 tccaagcaag cagatcccgc aaaaattccg gcataaaata ttctttttct gcagcgtcgc 2751181 gaatcaacgg aaacagtttg ccgagcgtaa acatatcaag caccgcaacg gagtattgtt 2751241 tatgtttttc aatatcttcc ccgttcagtg tgatccgagt gacgtgggtg atcccgtcat 2751301 cgagccgttt cgtttctacc tcaacgccgg catacaccat tttccccatc acttctccgc 2751361 ggaagccgag tcctttgatc cggagctgct ccatttgttc ggaagcggca tggacaatgg 2751421 tttccttcag ttcttctccc gtcaggcgga cagccaccgg gttgatcgga tgcggacaga 2751481 tgcggtgcag atccagcttt gtcacaggac ctgcttttag cggaccgaga atgacacctg 2751541 aattgaccat actgatgtcc gtctcgcacc attcctttaa ggcgtatgcc aaaagcaaag 2751601 gcagctctga ttcttcaaac cacttcacct cagcatcttg tgcaagctct gcaacggcat 2751661 cggacagttt ctcctcggct tcacgttctt tttcattgag aaacgcttta gtttctgcgg 2751721 attctcctgt ccattccgcc atgttctgca cagaagccgt tttgctgttg atgcttcgct 2751781 gtacgctgtc caccgtgatt tctacacagc cgacataatg cccgtatttc tcggcgctgg 2751841 ccagcagtac cccattaacc acttgtccat cttcgagcaa atgatgggta tgtgattcga 2751901 ggattacatc aatctcaggc accgcttcag ccactgcttg atcatcaaga atgcctaaat 2751961 gtgacagcag aacgataata tcagcctgcc ctttcacttc cagaatggtt tcctttatgc 2752021 tttcaagggc atccgtaact gtccatccca gcttgtcata tacaggataa tacggcacag 2752081 ttacacctaa gaaagcaatg gacataccgt ttttcaatga tttgatatgg taaggcaccg 2752141 cccaggacgg acggtttcca tttttatcaa acaggttaga gacgatgaca ggaaattcag 2752201 catgatcata taaggcagca agctcttcat gcggaagcgt aatcccttcg ttattgccga 2752261 tcgccgctcc atcaatgtga aggcggttta agagatcgac attcgctttt ccgaatgtcg 2752321 cctctgtcac gaattgaaaa cgatcaagat gatcgccaat atcaaaaacg agcgtctctt 2752381 cgccgtctga ctgatgctct tttcttttct gctcgatata atctacaatt ttcggccagt 2752441 tttcaaaatg gctgtgcaaa tcatttgtat gatataagcg gagcttctcc ttcataatat 2752501 ctctccctaa tcgttcagct gaaaatgcct tcataaatga gctggcagcc gatcaaaatc 2752561 aatacgatcc gcatgatcat aacgatcgtt ttcgtctgca tttttctgtt gatggcggcg 2752621 ccaagctttc cgccgaacca agcgccgggc acaagcgcga gggcgtacag ccaattgacg 2752681 tgcccggaaa tcatatgtga aacagaccct gtcatagaag acaggaaaat aataaacatg 2752741 gacgttgcca ccgcaacctt cggcggaaac agaaataaca gcatcatcgc cggaaccatc 2752801 agtgatccgc cgcctatacc gaaaagtccg cctaaaaaac cgacaacaaa ggcaatggca 2752861 ataccgacag aggcctgata tgagtacgta taaggctcac cggcatcatc ctgaaatgtc 2752921 cggataattc ctttgtgcgc tttgttgatt ggccgggctt tcgctttcag cattaaggat 2752981 aatgaaatca gaatcataaa aatgccaaac caaacggaaa acgagtttga attgaacagc 2753041 tttgacacgt aagccccgat catgctgccg ggacccgaac cgataaagaa aatgagtccg 2753101 ctcttataat caactgtttt atatttaata taagccaaag ttgaagaaag gcccgtaaaa 2753161 ataatgacca aaagcgaagt tccaatcgca acctgcggcg tcacatcctg aaacagctgc 2753221 gtcactgtgc ttaaaaacat cagagatggc acaatgacaa ttccgccgcc aagcccgatc 2753281 agacttccta ccgtacctgc gattaatccc agtacgacca aaatcacaaa cgacatcaat 2753341 caaaacctct tttctaaaat aaatcgagct gtctcggagc aagtccgctg tactcgatat 2753401 caagcagttc aagcatctgc ttgccattat ccgcagcgtc accgccggaa ttgttgttga 2753461 acaggacaaa aacatcctta cattgctgct gcaattcatt caggtgcttt ttccaatcct 2753521 ccagctcctg ttggttgtag cggtataagt acctgacctc ccgccagttt ttcccgccat 2753581 caggcttcat ccagccctgc ttgttgcgtc cgtgaaacct gacgagcgtt ttgttttcat 2753641 cggtcgcgcg caacacggtc ggaacgctgc cttctccgat ttgcggttca tcacagacac 2753701 tgtgaatcca gccttccgct ttcataaatg aaagcgtctg ctcataaaat ggcggcgaga 2753761 accaggaacg gtttctgaat tcaagcgcgc aaggaatatc tcccatttgg tgcttacacc 2753821 atctcaaata ggcgacattc tccttcttgc agtcaaacca cggcggaaat tgaaacagca 2753881 ccatggcgag cttattgcta tgtaaatatg gcgttaaaga caccttaaac gcatcaaaca 2753941 tctcctcttt tgagtcaaag ggaatttcgc cgcgctgatg ccctgtcatg ccctgatatg 2754001 ctttcacgat aaattggaag gtttcgggcg tttccttcac ccacttttca ttattgcgcg 2754061 ccggctgaat cgcgtaaaag ctcgcgtcta attccacgat cggaaaatgg gaggaatagg 2754121 cctgcaattt tttctggctg gccgttttcg gcggatagat gctgtcatga tccccccatc 2754181 ccgtcagtcc gatataaatc acactcattc acctctcttc cagtttatca cacgtgtttt 2754241 caggtttcct cggaaatgct gttcatatgg cgggaaaatg cctcacgcaa atgctgatat 2754301 tgttcctcat tcgtatctaa aaacgcctct tctcttgagg aaggaatgtg ctgatattca 2754361 ataggcgcct gaaactgctc actcgtaaaa tcgtacacca caccattgat gctgttataa 2754421 aaatgccagc tctcatcgac tcttgttttg aaaatcgtgc cgccgaaatg gtcttgaatc 2754481 accaatgccg tcacgccgca ttggccgcat gacgggcatt cttccgtcca tttagagctc 2754541 gaatggcgcg accaggattg cttaagtatg tatttgacat gctccattgc ctccgcctcc 2754601 tttaaaaaaa gataccacgt tgatgagatt ttaaaaacta gaacggagga aatcaaaaaa 2754661 cccggcggta aaatccgccg ggcttacgaa ggaacgacca gagctccgtc aatttcagtg 2754721 actttttccc catcattgta cacgcaccgg cctttgctgt aagtggccga aatgctgcag 2754781 ggaaatgtat gtccttcgta aatgcttttt ttatgctttg caaacatcga ttctcttgta 2754841 acagtgtacg gctccatgct gacgagcacg aaatctgcat cacaccccgc ctcaagccgc 2754901 ccttttttct gaaggccgaa tcgttttgca ggggccgccg ctgtccattc tgcgatggtt 2754961 tcaaatggaa tctgatgctc aagcgccagt tccagcattc ctaataaagt gaactgcccg 2755021 ccgctgattc cgccccatga taaaaacatg ttatcctccc gcttcaagga tggacggcaa 2755081 ggggaatggt ctgaggaaac catgtcaatg tccccggcaa tgagcgtctc gatcagcgtc 2755141 tcttttgatt gccgtgaccg gagcggaggc gcgcattttg cgacagagcc cctttgccgt 2755201 aaatcgtcat ggctgaacaa gacataatgc ggacatgttt caaccgaaac atcaagacct 2755261 tcctgtttcg cctctctgat cagccggacc gctttcgccg tgctgatatg gacaaaatga 2755321 accggacagc ctgtcacctt cgcatactga atcgtgcgat acaccgcttc aacttctgct 2755381 tcctccgggc gggaggcggc gtacgcatcc gcatccacct ttcctttatt ggccaaaacc 2755441 atctgcaagt agcttgtgat cgcgtcgctt tccgcgtgga gagcgaggat ttttcctgca 2755501 gccgcgattt ctgccatgcc tttgagcaat gtccgttcat caacagagcg gaactcatca 2755561 gtgcctgact ttgataaaaa cgctttaaac ccgatcgctc ccgcttcagc catcggacgg 2755621 atgtcctcga tatggcctgg cacaaggccg ccccatagcg caaaatccac ggcagatttt 2755681 tgcctgccta gctcagcttt tgcgagaaga tgctctgccg tcacggttga tggaatacag 2755741 ttgagcggca tatcaaaata ggtagtgcaa ccgcctgcgg ccatcatttg agaacctgtt 2755801 tcaaacccct cccaatcctc cctgcccggt tcattaaaat gaacatggca atctatcaca 2755861 ccaggaaaca cgtatttccc gtctgcctgg atgatttccg tcccgcttgc ttcaatgtca 2755921 gaacctatct cggcaatgac accgttttga actacaatat cagcttctat aacgccatct 2755981 ggcgtaactg ccttcgcacc ttttatcacc atatcgtaag ccatattgat ccccccatgt 2756041 caggatgacg attttccatg tcagtttatg taacacaacc agttctattt tcaacagttt 2756101 actgctacta tgatcgtatt acatcagcaa aaccgctaga attcctattg aaaattattc 2756161 accttaacca atgtttttat agaaaaggag aatgcgctat gaatattctt gatgtgatga 2756221 aaataccggc ttttgaaaac gccaatttaa tcgctggaaa agcaggaggg gaaagagagg 2756281 ttcagcatgt caatatgatg gacgctccgg atatcgtaga ctttttgcat aagaatgaat 2756341 tgctcgtcac caccgcctat cacctgaagg atcacccgca tcaattatct gaactgattc 2756401 ggcaaatggc aaaacgcggc tgcgcgggcc tcggcattaa aacaaagcgc tatctggaag 2756461 atatcccgaa ggaaatcatc gaactggccg attcatatgc gtttccgatc attgagcttc 2756521 cggaacacat ccgactcggc gatattgtga atgccacact cagccatatt ctcgatatgc 2756581 gttctaacga gctgcagcaa gccatttacg cgcacaaaaa attcacaaac cacattatga 2756641 gcggcaaggg gctgcaatcc ctcctcaaaa aggtgtcaga catccttcag cttcccgtgc 2756701 tgctgcttga ccagcatgcc aaaatgctgt ctgcgtctca tcagatttca gttgagaccg 2756761 aaaagctgaa aggcaccctg aataccgtat ccgggccatt tttcacttgt ttctctacaa 2756821 tctcagatca gaaaacatat tctgtcctgc ctatttataa tcacgaaaaa aactgcggct 2756881 acctgctgat acccgacatg gtgcaggcag gcgacaaagg attgatcctc acgattgaac 2756941 aagcggccaa cgtcatttcc tttgaactgc tgaaggaaaa tgcgctgaag cagttcagcc 2757001 ggcgggcccg caatgagttt ttcaacaatt ttattgagcg gaccttttct tcagatgacg 2757061 aaatcaaaaa ccgggcgaaa gaattcaagc tgcgctggga tcaaaaatac atgtgcatcg 2757121 ccggcaaact cgatcgcaat gacgaatcaa tcagctttac agaaaatcag ctcgcttccg 2757181 acagcgtatt cgaatttctt gaaggtgaat tatcagcctt cccgtttcca cctcacttct 2757241 ttatgaaagg aaatgtcggc attattctaa tcgaggcgac agacagctgg agtgaaatgc 2757301 acgcctcggt gatcagcttt ttagaacagt ttcaaacaca ggtcagcgct caatttaaac 2757361 gaaccgtgtc ctttggcatc agcaatatct gccaaaagct cattgatgtt cccgacgctt 2757421 tcacagaagc ttctgatgct ctgcaatcgg ggcatttgtc aagaagcacc gcatttatcc 2757481 aggtgtatca cgccaaagat gtgcctgagc ttctgcgctt gctcccagtt gaggatttga 2757541 agaaatttta caactccacg cttcagagcc tcgctgaaaa acagcaggag gatcaaagcc 2757601 tgcttcatac gctttccgtc tatttagaga cacactgcca aatttcagag acggcaaagc 2757661 gtctgtacgt tcatcgcaat acggtcatat accgccttga aaaatgcgaa gagcttctgg 2757721 ggaaaagctt aaaagatcct gaaacaacga tgcgtttgcg gcttgcatta cgtatgcagc 2757781 ggctgatcag ctaaagtttg ttacattttc ttacaaaacg aatcgttttt cgtcactttc 2757841 agcaatcaca cctgtctttt tcagctactg tatccaatga cacccctcga ccggaacgat 2757901 attatgttac taaagttcac atacagggag ggactatagt gaaaaaaaga tcgtttaagg 2757961 tgtttacact tagcctgcag catgtgctcg ccatgtatgc aggtgcgatt ttggtgcccc 2758021 tgcttgtcgg cagggcgctg aatgtaacaa ctgaacagct gtcctaccta ttggcgattg 2758081 acctgttaac atgcggcgtc gctacgcttt tgcaaacctt gcgcggaaca tacatcggca 2758141 tcgggcttcc cgtcatgctt ggcagttcat ttgtggccgt caccccaatg attgcaatcg 2758201 gcagcaatta cggcattcac gcgatttatg gttccatcat tgcggccggt gtgttcatct 2758261 ttttgtttgc gcgttttttc ggcaagctga ctgtgttatt tcctcctgtc gtaacaggta 2758321 ccgttgtgac cttgatcggc ctttcacttg ttccgacagg tgtgaaaaat atggctggcg 2758381 gcgaaaaaat aaacggcagc gccaaccccg aatacggttc gctcgaaaac cttcttctct 2758441 ctgtcggtgt ccttgttctg atcttagtcc tcaaccgctt tctcaaagga tttgcccgaa 2758501 cactgtccgt tctgatcggc atcgccgccg gaacagcggc agcagcgatc atgggcaaag 2758561 tcagcttttc ttctgttaca gaagcaccgt tcttccaaat cccgaagcct ttttacttcg 2758621 gagcccctgc gtttgaaatc ggtccgatct taacgatgct gatcgtcgga atcgtcatta 2758681 ttgtggaatc aaccggcgtt ttttacgcaa tcggaaagat atgcggcaga cctttaactg 2758741 acaaagatct cgtcaaaggc tatcgagcgg aaggaatcgc cattctcatc ggcgggctgt 2758801 tcaatgcctt tccttataat acctttgcgc aaaacgccgg cttattgcag ctgaccaaag 2758861 tgaaaacaag aaacatcgtc gttaccgcag gctgtatcct tgtctgtctc ggactgattc 2758921 cgaagattgc cgcccttgca tctgccgttc ctgctgctgt acttggcggc gcgaccgtcg 2758981 tcatgttcgg catggtgatt gcctccggcg tcaaaatgct cagcacagcg gatctcaaaa 2759041 atcaatacca cctcctgacc atcgcatgct caatcgcact cggcatcggc gccagcacgg 2759101 cccccgggat ttttgctgaa ttccccgctc cgatccggat tctggtcagt gacggcacca 2759161 tcaccggaag cctaaccgcc atctttttga atctattttt cagcttgcgc gacaaaaaag 2759221 aattaacagc acagcaaaca gaacttccgg tattagaaca tacactcgca ttagaaaaag 2759281 aggtgtaaaa aagatgaagg aacagcacaa tgccttacag ctaatgatgc tggggcttca 2759341 gcacatgctt gccatgtatg cgggagccat tctcgttccg ttgatcgtcg gagcagcgat 2759401 cgggctgaat gcggggcagc tgacgtattt aatcgcgatt gatttgttta tgtgcggggc 2759461 ggcaactctt ttgcagctct ggagaaaccg atatttcggc atcggccttc ccgttgtgct 2759521 cggatgcacg tttaccgcag tcggcccgat gatttccatc ggaagcactt acggtgtccc 2759581 agcgatatat ggtgccatta tcgccgcagg actgattgtc gtcttagccg cgggcttctt 2759641 cgggaagctt gtccgttttt ttccgcctgt cgtaaccgga tcagtcgtca tgatcatcgg 2759701 catcagcctg attccaacgg caatgaataa cctggccgga ggtgaaggaa gcaaagaatt 2759761 cggctcactc gacaacgtgc tcctcgggtt tggcgtcaca gcttttatct tattgctgtt 2759821 ttatttcttt aaaggcttta tccgctccat agcgatttta ctcggtctta tcgcaggaac 2759881 agcggctgca tatttcatgg gaaaggtcga tttttctgag gttttggagg cgtcttggct 2759941 tcatgttccg tctctgtttt atttcggacc gccaaccttt gagctgccgg ctgttgtcac 2760001 gatgcttctc gttgcaattg tcagcctcgt tgaatcgaca ggcgtttatt ttgccctcgc 2760061 tgatatcaca aaccgcaggc tgtcggagaa ggatctggaa aaaggctacc gggcagaagg 2760121 ccttgcgatt ttgctgggcg gcttatttaa cgcgtttccc tatacagctt tctcgcagaa 2760181 tgtcggcatc gttcagctct caaagatgaa aagtgtcaac gtcatcgcca tcacaggaat 2760241 catactggtc gcgatcgggc tggttccaaa agcagcggcc ctgacaacag tgatccccac 2760301 cccagttctc ggcggcgcaa tgatcgtcat gttcggcatg gtcatttctt acgggatcaa 2760361 aatgctatcc agcgttgacc ttgattcgca aggcaacctg ctgattatcg cctcttccgt 2760421 cagcttgggg cttggcgcta caacagttcc cgcgttgttt tcatctcttt cgggcgcggc 2760481 ctctgtcttg gcaggaagcg gaattgtgat cggcagtttg acggccattg cactgcacgc 2760541 tttttttcaa accaaacagc cgaatagcgc agacataaaa acgtaaagga agatgccaat 2760601 gttcacaatg gatgacctga accaaatgga cacacaaaca ctgacagaca cacttggctc 2760661 tatttttgaa cactcttcat ggattgcgga gagatccgca gcactacggc cgttttcgtc 2760721 cctttctgat cttcaccgca aaatgactgg cattgtaaaa gctgcggatc gcgagacaca 2760781 gcttgattta atcaaaaagc atccccggct cggaacaaag aaaacaatga gcgatgactc 2760841 ggtacgagag cagcagaacg cagggctcgg caaattagaa cagcaggaat acgaggagtt 2760901 tctcatgctg aatgaacact attatgatcg cttcggcttt ccttttattt tagcggtgaa 2760961 gggaaagacg aaacaggaca ttcaccaagc cctgctggca aggcttgaga gcgaacgaga 2761021 aacggagttc cagcaggccc ttatagaaat ttaccgaatc gcccgctttc gtctggctga 2761081 catcatcact gaaaaaggag agacgcaaat gaaaagaacc atgtcttatg gcaaaggaaa 2761141 tgtatttgca taccgaacgt atttaaaacc gctcactgga gtgaagcaaa tcccggaatc 2761201 atcttttgcc ggaagagata ataccgttgt cggcgttgat gtgacatgcg aaattggcgg 2761261 agaagccttc ctgccatcat ttacagacgg agacaacact ctcgtcgtgg caacggattc 2761321 aatgaaaaac tttatccagc gccatctcgc atcctatgaa ggaacgacaa ccgaggggtt 2761381 cctacactat gtagctcacc gatttttaga tacctattct catatggaca cgatcactct 2761441 gactggcgaa gacattccgt ttgaagcaat gcctgcatac gaggagaaag agctcagcac 2761501 aagccgcctc gtcttcagaa gatcgcgtaa tgaacgaagc cgctctgtgc tgaaagcaga 2761561 acgaagcggg aataccataa cgattacaga gcaatacagc gaaatcatgg atcttcagct 2761621 cgtcaaggtg agcggcaact ccttcgtcgg cttcatccgg gacgaatata cgactctccc 2761681 ggaagacggc aaccgcccgc tgtttgtcta tttaaacatc agctggcaat atgaaaatac 2761741 aaatgactca tacgcttctg atccagcacg ctacgttgcg gctgaacaag tccgcgactt 2761801 agcgagcacc gtttttcacg agctcgaaac cccttcaatc caaaacctaa tctatcatat 2761861 cggctgcaga atattagcga ggttcccgca gctcactgat gtcagcttcc aatctcaaaa 2761921 tcacacgtgg gatacggttg tcgaagaaat cccgggctca aaaggaaaag tctacaccga 2761981 accgcgcccg ccatacggtt tccaacattt taccgtgaca agagaagacg ccgagaaaga 2762041 aaaacagaaa gccgctgaaa aatgtcggag cctgaaagcc tgatgggaaa actgacaacc 2762101 catattttag atttaacctg cggcaaacca gcggcgaacg taaaaattgg attgaagcgg 2762161 ctgggcgaaa gtattatgaa agaggtatac actaacaatg acggcagggt cgatgtccct 2762221 ctgctggctg gtgaagagct gatgtcagga gagtatgtga tggaatttca tgcaggagac 2762281 tattttgcga gtaaaaacat gaacgcagcc gatcagccgt ttttaaccat cgtcaccgtc 2762341 cgttttcagc tagcagatcc agatgcacat tatcatatcc cgctcttgct gtcgccgttt 2762401 ggttatcagg tgtatagggg gagttaagaa ggaagcccgc ctcaccggcg ggcttctttt 2762461 tgcacttcaa ttaacttttg atcctaggac agtacttgaa gtgatcccca cacttagtga 2762521 aacaacagct agaataaaca ttcacctata tttttcagga taattgccta cgagaaaaat 2762581 accctgtagt cctttcattt ataaatcgag gtttcaaact aataagtcag ctcttagcag 2762641 ccgagctccc ttctccaatc ctataaacag accgcgtttt ttctcgaaaa aatactctga 2762701 agacaattgc tgcgttttta atagttttga taacgcgttc tctcttacac ctttagacaa 2762761 aatattcatt ttttcttttt tagacttaaa tctatgtcga aaataatcgt tggcatatct 2762821 tatcctatct ccactaaagg aggtgacatt atgggattct acaattctgg tggatacagt 2762881 ggaaactctg gttactcaaa cggtttcggg agctccttcg ctttgatcgt ggtgctattc 2762941 attttgttga tcattgttgg agcagctatc tttaattatt aagtttaact ttccttgcct 2763001 ccgccgtatc caacacctcc ctgtccgaca gacgccataa gaagttttta tggcgtcttt 2763061 gctatgtgtt cactaatctt tttgtaatcc agaagctgtc aagttctacg agatttatcg 2763121 tgtgttttcc cacaacgctt ctgcgtcttg atcgcgctgt ctgactgagg ctaaaaaagt 2763181 ccggctttta aaagccggac tcccgtctac ccccgttcaa ctctcttcta atcctgcaag 2763241 ctgaccgcat aatcccgcca tacccggtac accggcacaa attccccgcc agcccttctt 2763301 ctatatcttt gtcagaaggt tgaggggttt cccgaaacaa tgctttaagc gcaatgatca 2763361 ttcccggcgt acagtagccg cattggaagc cgccttcttc caggaaagcg gtttgacaca 2763421 tatccagctc ttctttttga agcccctcga tggttgtgat ggaatggccg tctgcttgat 2763481 aggccatcgt catgcacgca ttggccagtt ttccgtcgat taaaatagag caggctccgc 2763541 agcggccgat tccgcaggac acctttgtcc cggtcagctg aaattccttt ctaagcaggt 2763601 cactcagatg tgtcgtagga acggcagcaa cctcccacgc ctgaccattc acggtcatcc 2763661 ggaactgttc cttttttaca ggaaatggcc cggcctcttt tatgtccatt gcttcagccc 2763721 ctttctgtcg atcgcttcaa gcaactcttc tcttgaaatt ggcagcttgt ttatccagca 2763781 tccgaccgca tcatgtactg cctttacaat cgccggagtg atggcgattg ttccgatttc 2763841 accaacaccg cgcggtccat atacgtctcc cttcattaag tcttctattg caatcagctt 2763901 catgtcagga acatctttga ttccgggaat caaatagtga tcgagatttt ccgcagcata 2763961 acggccatcc gtcattttcg cttcctccat cagtgtgtag ccgagtgcca tggcagcgcc 2764021 gccttcaatt tgacctcgat atccctgcgg actgacaacc ggacctgccg caatagcgtg 2764081 ctcacaatct atcaatttga catcgcctgt taacagatct acctccacct caacggcagc 2764141 cgctccaaat gagtagagga aatggccgcc caccacagga tcaggcgttg ttggaaagtc 2764201 aaaggccgtt tcctctgcca aagggccttt ttcagccagc tccttatacg tcaccacgag 2764261 cgcctttgtg tttttgtcac gcaagcctgc agcgccggga ataagatttt ccgctgaaca 2764321 gccgctccat tctgccgccc gttttttcaa ctgagctaga aacggcttct tcaaacgctg 2764381 gatcgcgtgc cacaccatgc ttgtgccgcg ggatgctgtg gaggagcctg acttcggcac 2764441 ttttgcggta tccccaataa caatggaaat atcctctgcg gcacaaccca gctcctccat 2764501 gacaatctgt tcaatcgctg ctagaatccc ctgtccgcat tcttcaaatc caaacgaagc 2764561 agtgattttg ccttcactcg aaagagacaa acggcctcct gccgcatcca ttcggccaaa 2764621 ccccagcccg ccgccgtgca ttgtaattgc cgctcccgtg cctctttgca gatacccgca 2764681 gttccggctt gtttttttaa gaatgggaga tttagatatg gcattcaaca cctgtgccgc 2764741 tccgtcagtt ggtgcaattc gatgctcaag cggccccaag tcatgcggtt ttctgatatt 2764801 ttttcttctc agctcgagcg ggtcgatgcc aagcatgccg ctgagacgat cgagatgggt 2764861 ttcgagtgca aatgtgattt ggttgccgcc aaagccccga aattcccccg ccaccccgtt 2764921 gttcgtaaat actgatattc cttcagtccg gatattcgga atacggtacg gccccgcggc 2764981 atgctcgaca gaaaaatcaa gaacagccgg tccgagcgta gcgtaagcgc ctgtgtccgc 2765041 cacaattttc acgtcgtgcg ccaatagatt tcccgaatga tctgcacccg tttttatcgt 2765101 aatcttcatc ggatggcgct taatgccaga acgtacagat tcctttcgtg tctgatgaat 2765161 tttgacaggg cgtccgcttt tcagggccaa aagcgcagca tacggctgaa tattcagctc 2765221 atccttccct ccgaacgagc cgcccatcgg acttgacaca attctgatct tctcttcagg 2765281 aatatcaaaa atacgggcaa gctggaaacg gtctttatag ccgtgctggg ttcctgcata 2765341 catcgtaaaa cccccgtcgt cttccggaac ggctacacct ccctccgttt ccatatacgt 2765401 atgcatctgc cgcggcagct cataggtttc ttcaaagact gtgtcagatg cttgaaaccc 2765461 ttcttccaca tcaccgtttg aaaaaaatgc gcggtgcagg atattcccgt cctcatgcag 2765521 tctttgcgca ttcggccgaa gcgctttttc tggtgaatcc atgacttcca gctctttata 2765581 ctcaacttga atcagctcca gcgccgcttc cgcgatttct tccgtttccg cagcaactgc 2765641 ggcgatcgca tccccgacat accgcaccct gtcctcacat aaaaccggct gatcagggat 2765701 gacaatgcca aatcggttta agccgggaac gtctttatgt gtgacgacgg cctgcacgcc 2765761 ttccattttc tcagctttta tggtgcaaac cgacacaatc tctgcatgag gataagcact 2765821 tctcagcacc ttgccataca gcattcctgg aaagctgaga tcggtcatat atttcaattc 2765881 ccctgtgacc ttaccccttc catccggcct gactcttgac ggtttgttga tgatcattta 2765941 ttcccctccc tcagccatca gctctgccat gatgacgttg gcagcggctt tttttctgta 2766001 tgccgctgac ataaaaacat ctgaggaaaa cggcagctca tggataagtg ttttgtacag 2766061 ctcatgcggg tcccaccctg gtgccatcca tttcgcttcg ctgtccaata atctcctagg 2766121 agtgatatcg gcatggccag cggcgaggcg aatgctgccg tctttcaaaa aacgtccagc 2766181 tgcaacagca gccgctccgg taaaagcctg gcgccttcca agcttgtgat aaaatacacg 2766241 ctctccctcc gcccgcggga tgatgacacg cgtgacgata gccgttctaa agtcttcctc 2766301 actgagccaa gcgccaagcg gcagcctgat tagctccttt tgatatacga taagctcagc 2766361 accaagcaca agcagaagcg gaatgaaatc accgatttta ctcgctatgt tgccgccaat 2766421 cgtggcacgg ctgcgaatcc ccggtgcagc gacagcggaa gcagcgtcac tgaaacagct 2766481 aagcgctctc ttaatcaaag ggttctttct gcattcattc agtgatgtga gccccccgat 2766541 cgacacgtgg gtgtcactgg tgctgatccc tcgcatttcg tcaatccctt caaggctgac 2766601 aaggtgctgt ttcggtagag ttcctttgtc ccactgaagc tgaaggagcg tgcttcccga 2766661 tgcggcacac acatccggag caagcttctc taaaagcgaa taggcctcat caagcgctgc 2766721 cggtctccat aattgaatat tcatccttgc ttttgtcact tggccgttca agacatcgcc 2766781 ctccttacca tgtcatattc ctcgggtgta tcaatatcgt ccaactcacc gctatccttt 2766841 gcctccaaaa ccgctcctgc tccaagctgt ccgcttttca ggagcctgcg agccccttca 2766901 tctcccttta atccctttac ataaggaaaa catgtcgacg agaagtagat tggcggggtg 2766961 aacgccccta aaaacgatga cacggcaaat gactcaggag ccagagccac aagggcattg 2767021 agatgatcga cggaaagctg aggctggtcg gctaacaaaa tgacaatgcc gtccgccccc 2767081 atgctttctg cttttctcac cccgctgctg actgaatgcc cctgaccctt ttctgcgtct 2767141 tggcaaacgt gcaggctcca gcgtttttga aaaggcggag cgtgatacgg cgctcctatc 2767201 cactcaaggg aggcatgttc tgtccgctcg acgaccagca cgtgatcaag gcgggacgac 2767261 agagcagttt tcaaggaaag tgagcctatg ttttctcctt ttagcggcaa agccagcttg 2767321 ttttgtccca ttcttctgct tttgccggca gcgagaaaca cgccgatcag ataggggctt 2767381 ctcatacaac cgccacccgt tttcttgttt gaatgatttc tgcaactaca cttaccgcaa 2767441 tttcctcggg accttccgca ccgattttca gcccgaccgg actgtaaaag tgagacggag 2767501 gatgttttcc gctcagcagc cgtttcgtgc ggtttgccga acccaacagt ccaatataat 2767561 ggaggttttg agaaaataag aagttgatga tcgtttgatc gtgctgataa tgatgggttg 2767621 ccacaacagc tgcatcatgc ggaaaaaatt gaaattcgct aagcatttgt tccggaaaag 2767681 cggtgatcag ctgatccgct tttggaaaaa gagaggatgt acaataagcg ggccgccaat 2767741 ccgtcacgat aacagaaaac cctgtgtcag ccgccaaatt ggccagcggt acattatccg 2767801 gtcccgcccc aaacagaatg agacgcggct tcggttcaat tcgctgaata aacatgttag 2767861 tggtttgatc gaaatgcggt aaatgaagcg ttgaaacagt acgttgaata tcttgcagag 2767921 gcgcgtccgg ccagttccca aaatgtccgt tctccgtcag aaataaataa tgggaggatt 2767981 caatctttat aacggaagtg acagctttgc ctgaatgaag gcagtccctc actttctcat 2768041 agtgccgcct tttttcctga gtgattcgct ctgcatgaac atgaataatg ccattgcacc 2768101 cggctcccat gccccaagaa agatcgtcct ccgaccgcat gtcgtaggga atcagcgttg 2768161 atgtgagctg atcgcccagc gcactgattc tttggaatac atcttcttcc acacacccgc 2768221 cgctcagcaa gccaatccgt ctgccttttt tcttaaagag catagaggcg cctgcttttc 2768281 gatacgcgga gccttcaact tgaacaattg tcgccagtac agcctcctcc tggtcttcca 2768341 ggagcgcatc taacatcgtg tgaaaattcc ccaatgccgc atcctcctct cgaaaattgc 2768401 cgtgagaaac aactagttca gcgtgatttt ataggtaact tgtataaaga atagacgatg 2768461 gaagaaaaaa tgactcatga tttgtcagaa aatgaaacac atagaaagag gatttgtaaa 2768521 aagagtcaaa cgaagaaaat cagattggag aaaacacgaa atcatatcgt taaaaagctt 2768581 gcggagttcc gcaagctttt ctttacaccg ctgcctggcg gccagcgttt tcatacacat 2768641 ccagcgctgc ttggagcgct tttcctgctt cgattcctgc gttatgtctg agaagcacag 2768701 cctctaaccc ggcaagcacg aatagcacgt tttcttttct gcagctgtac cccatcgtgc 2768761 cgatcctcca gatcttccct gcaagcgggc cgaatgagct ggcgatttca atgccgaatt 2768821 gtgccagcag catgtcacgg acagactcgc cgtcaatgcc gccgggaatt tcgacacagg 2768881 tgacaacagg cattttgcag ctgtcatctc caaacaatct tagccccatt gcctttatcc 2768941 ctgctgctaa tgcggcttca tggtgccgat gccgctcgaa acgcgtctca agaccttctt 2769001 caagcaccag tctgactccc tcacgtaagg cgtacagcat cgtcgtcgct tctgtatgat 2769061 gattgagccg tctttcgctc caataatcct caagctggct caaatcaaag tagttgcttg 2769121 taattggccg atttcccgaa agtgctgccc tgtcagcttg tgtcgcaatc ccgcgttcca 2769181 cctttttgcg agctgcaatc acgtccgcca cccgctcatt atatgtaatc ggcgccattc 2769241 ctgaaggcac agacaaacat ttttgcgttc cgccgatggc agcgtcaatc ttccattcat 2769301 cgactttaac ctcgcagccc ccaatcgttg cgactgcatc gacgataaac aatgcatcct 2769361 cggtgcggca ggcttcgccg atggctttca gcgggtgaat ccgtcctgtc gatgtttctc 2769421 catgcaccat ggccacaatt ttcggcttca ctttttttat ctcccgtatg atgtcctccg 2769481 ggtcaaaaac cgttccccat tcgcactcca gcatatgaac atttgcccca tatcgctcgg 2769541 cgatttcagt cagcaaataa ccgaaacggc cgtaaatggg aatgagcaca tcatcttccg 2769601 gctctatcac actagccagc actgcttcaa ttcccgcccg tgaagtgccg tcaatcgggt 2769661 atgcccagcg gttttttgtt tggaacagct cccgaagcat ctccatcgtt tcattcataa 2769721 tacctgtaaa cgccggatca aattggccga caaccggggt gctcattact cttaatacac 2769781 gcggatcaac ctcaacaggc cccggtgtca taatcgttct taacggggtg cataattctc 2769841 ttctgcctga cacagccatt cctcctttat cagtaagcca gtttgtataa taaatcagtc 2769901 agtgcgcgga cgccgatctc aagctgtctg gctgacgtat attccttcgg tgagtggctg 2769961 acgccgcctc ggctcggcac aaacagcata caagcaggat agcgccttcc gatcatttgc 2770021 gcgtcatgcc ctgctccgct caccatttcc tcacagctga agccgttttc taatgctgtt 2770081 tcaaaagccg cagccttcag cctttcgtcc atcggcacag gctctatccg catatattca 2770141 tcaatcacag cgcgaattcc tttttgtagg caaatgccgt tgatcaaagc aaccatgtct 2770201 tgatgaaact gttccagcac atgctgatgc tgatggcgaa tatcgattga aaactggacg 2770261 cggcccggta tgacattggc tacattgggc tctgccgtta tttttccgca tgtcagacgg 2770321 agctcatccg gcagctcatc cgaccgcagc agcagctcat gaatgatacg gctgctggct 2770381 gcgagcgggt ccttgcgcca tttcatggag gtggttcctg cgtgattgca ttctccttcg 2770441 agcgtgacga gatatcgtct ctgccccgca atacttgtca cgatgccgag atcccggcct 2770501 gacatttcca acgtcttccc ctgttcaata tgcagctcaa caaacgcgct gatatctgtc 2770561 ctatatgctg actgaaacac acctttgcca aaaccgctct catgcatcgc tgtttggagg 2770621 gagactcccg actcgtctct tggctctttt gcatcttgtt ctgaaaaaac acccgtcata 2770681 ttccccgacc cccaataggt cattggaaaa cggctgcctt cctcctcaca taaggagacc 2770741 gcctcgagcg ttttttttgg cgctccgtat gtttccttga gctgctttaa cgcgagcatt 2770801 gccgccagaa cgccataggc gccgtcgtat tttcctccat tgatgacagt atcgatatgt 2770861 gaaccggtta caatgacttc atccggagac tgggtgcccg aaagccttcc aaacacattg 2770921 ccgacatcgt cgaatcttgt ttcaagcccg aaagaagaca tttccgtttt cacagcaagc 2770981 tgtgcgtcca tccactcttt tgtgtataaa agcctcgtta cgccgccatc cgcagacgca 2771041 ccgtattggg cgagccattc aatataatct gtgatgctgt tttttactga aagcttctgc 2771101 ttttccatgt actcccccct ctggccgcta tggtgacttc attatagaag gagcaacatg 2771161 atagttcatt gacagattaa ccaaaaaaac gtttattttt tagccacagt atccatccag 2771221 caaccagata caccctacat gtcacaacta ttttgatgta aaggtcaaaa gaaaacacgg 2771281 taaggaagag agccagcaag agcgaaagag agggtcaaaa tgcctttcat atgaacaagc 2771341 taagctggag aggcgatgtt cgcggaacgg atgaaaacag aaatgccggc agcccgcaaa 2771401 aacaggacct aaagatatgg aaacaggaga tttccgcctc ctccaaaggg actaatttac 2771461 aattttaatg aaaaatatac aaaatgacac ttctatcctt tatttcaatt ttagataata 2771521 gatatgatct gataaaagga gggcaagtga tgacaaaaaa agcatggttt ctgccgctcg 2771581 tctgtgtatt actgatttcc ggatggcttg cgccagcagc ttcagcaagc gcgcaaacca 2771641 cattaagcct taatgaccga ttggcgtctt ccccttcagg aacgggaagc cttctctcat 2771701 tagccgcccc cgctgcaccc tatgctgaca cagataccta ttatgaaggg gctgaaggta 2771761 aaacaggaga ctcgctaaaa agcaccctgc accgtattat cagcggacac acgatgctgt 2771821 cctacagcga agtgtggaac gcgctgaaag aaacggatga agacccaaga aatccgaata 2771881 acgtcatcct gctctatacg aatgaatcgc gttccaaaaa cctgaacggc ggcaatgtcg 2771941 gcgattggaa ccgcgagcat gtctgggcga aatcccatgg cgattttggt acgagcaagg 2772001 gacctggtac tgatattcat catttgcgcc cggctgatgt tcaagttaac agcgccagag 2772061 gaaatatgga ttttgacaat ggcggcactg aatatgcgaa ggcacccgga aattattatg 2772121 acggcgattc atgggagccc cgcgatgatg tgaaaggcga tgttgcccgc atgctgtttt 2772181 acatggctgt ccgttacgag ggtgatgacg gctatcctga tcttgagctt aatgataaga 2772241 caggcaacgg ctcagctcct tatcatggca aacaatctgt cctgctcgaa tggaataagc 2772301 aggatccggt tgacgaccgc gagcggaaaa gaaatgaaat catttatgaa aaatatcagc 2772361 acaaccgcaa tccatttatc gaccaccctg aatgggcgga tgagatttgg ccgtaagaaa 2772421 aaggtgctcc ttttgaggag cacctttttc taatacacag cctcttccgt ttccgcatcg 2772481 aaaaagacga cgtggtccat tttcactgag agctggattg aatcgcctgc atcgattcgc 2772541 gtgtttccgt ccaggcggac cttgagccgc tcgtccccag ccatgacatg cactatgagc 2772601 tccgagccca gattttcatt cacttccacg ttcgcttgaa acactgaatc aaacaactgg 2772661 tcatttcctg tcatttgtgt gatgtgctcc ggccgtacac cggcaatcat ctgttctccg 2772721 gcatatccct tttccttcag ccgctttgct ttttcttcag gaatatgaag ccggatcgaa 2772781 gaatttgtga aaaacagctc gccatgctgc tgttctatga tgcctttcaa aaagttcatt 2772841 ccgggagagc caatgaagcc tgcgacaaac aaattggccg ggtaatgata aatgtcatga 2772901 ggtttcgcca cttgctgaat ttccccttca ttcatgacga caatccgatc tcccattgtc 2772961 attgcttcgg tctggtcatg cgtgacataa atgatcgttg cctctaatcg ctggtgcagc 2773021 ttgctgattt ctgtccgcat cgtcactctt agttttgcat ccagattaga aagcggctcg 2773081 tccattaaaa agaccttcgg ctccctcaca atcgacctgc caagcgccac cctttgccgc 2773141 tgcccgccgg agagcgcctt cggttttctc ttcagcaaat gttcaatttc taaaattctg 2773201 gctgccgcat gaacccgctc ggcaatttcc tgtttcgcca tctttctgag ctttaatcca 2773261 aacgccatat tatcaaaaac cgtcatatgc ggataaagcg catagttctg gaataccatc 2773321 gcaatatcac gttctttcgg cggaagatca ttgacccgct ccccatcaat aagaagattt 2773381 ccttcagaaa tgctttctaa tccagccacc atccgcagcg ttgttgattt tccgcatcct 2773441 gacggcccca ccagcaccaa aagctcctta tcctttacat ctaaatcaaa gtccttcacg 2773501 gttaattgtg agtgatatga ttttttgacg tgttcaaatg ttaatgaagc catcagaaaa 2773561 gtccccctat cttttgaccc gttatttcgt cactggaaac aacttggtct ttctgttatt 2773621 tttagagtaa tcgattccca tttttgctat atttctaaaa taaaaaatgt aaatttgtat 2773681 tataacgtca taatacatta taatataaat aataggttaa aaggaggcta ccctttgtta 2773741 aacaacggaa gttctacacc tttatacatt cagctaaaac aaatcatcac tgatgacatc 2773801 aaaaagggcg tgtattcccc aaccgccaag ctgcctaccg aaaacgagct ttgcaccaag 2773861 tataacgtca gccgcatcac cgtcaggaaa gccattctcg atttagtcga agaaggctat 2773921 ctgatcaggc agcagggaaa gggaacgttc gttaaaagcc ctaaattaaa acgagagctg 2773981 atcgctgtaa acggctactc ggaatttatg gaatcaaccg gcaaaaaacc gaagcatcat 2774041 gtgctgtccc atgacatcat tccagcgtca aaacccatcg ccgaaaagct tcaaatccaa 2774101 cccgagagcc ctgtggttga attaaaacgg attttatata atgatgatca gcctctcacc 2774161 tttgaagtga cgcattatcc gcttgatttg tttcccggca ttgatacctt tattgctgac 2774221 ggcgtctcca tgcatgatat tttgaaacag caatacaaag ttgtacccac gcacaatacg 2774281 aagctattaa acgttgtata tgcccaacag gaggaaagca aatacctgga ttgtgatatc 2774341 ggggatgcgc tgtttgaaat tgataaaacg gcttttacat caaacgacca gccaatctat 2774401 tgctcattgt ttttgatgca cacaaaccgt gtcactttta ccatcaacag cccctacaca 2774461 taacaggcat aaaaaacgag acactgctta tagtattctc gttttttcac tgcttccccc 2774521 gtcctccaag cgataaggat agccatagcc gaaagctccg tacacaccgc aagttttcgc 2774581 agccgtttca gcagcctggc gcaaagcata cgttatatcc tgcttcacgc aaaaggcagt 2774641 caaaaagcct gctataaaag aatctcccgc tccaagtgta tctattatat cagcttccac 2774701 aatcggctga tgatagactc gatcacccgc agacaggatt gctccttggc cccctcgggt 2774761 catacaaacc attttggctc cgtacccatg agctgttttg gcaagctcac cgcattccga 2774821 ctcactcaaa tcgcttcctg aaaaaaacgc atacgtcaca taaggacaga ccctcctcaa 2774881 ataatcatcc tcccgattgg ttgaaaaatc aaatgagacc gggaccagcc cgcacagctg 2774941 cggaagatcg ttctcaagcc tgctgtacac gctcgtatgc agcagatcat gcccgctgat 2775001 aaaagataca tctttctcct gaaacgcgag gcgaagccgg gactgaatgc cgcctttatt 2775061 tgatctgaca aaaatgcggt ccccctgttc atcaagggtg acaatcgcca tcccgttttc 2775121 tccgtgcgcc tggcggatat aatctgcatt gacctgctcc agcttgagaa cgttcaacag 2775181 atgcgccgcg gcttcgtcat tgccgacgat tccgatatag gaagactcat gcccgagccg 2775241 cttggcaagc acagcaacgt ttaaggcatt tcctcccggg taaaatgttt cttgatcctg 2775301 gtagtaatct acaacattat ctccaaccgc aatcaatttc atagcgcttc ctcctttatc 2775361 cttttacact gccgcttgca atcccgcgga caaaatattt ctgcatcaat aaaaatagaa 2775421 taataatcgg cgcggctgaa atcgttaacc ccgccagcag gacgccccag tctgtctgca 2775481 gcgcgtctct gaactgcatc agcccggctg gaatggtccg taaattctca tcatctatga 2775541 aaataatcgc aaacataaac tcattccatg tatggtaagc cgtcaaaatg ccggatgtca 2775601 ccaaaatcgg cacgctcatt ggtaagaaaa ttctgaaaaa tactccaaaa cttgtacacc 2775661 catccaaata ggccgcctcc tccaattctt ttgaaataga aagaaaataa gagcggatca 2775721 aaatgatggt gaatgggatc cgataagccg catacggcaa gattaacgcc caatacgtat 2775781 tgtacaggcc cagcgactga ataatagaat aaagcggcac aagactgacc tgcggcgtca 2775841 gcatcaatcc gccaagacat agcaccaaaa agaatccttt tcctttaaac tcaaaccggg 2775901 aaaggccata cgctgcccat gcactgataa agacagtgat cacacacgtc agcgccgtaa 2775961 cgatgacact gttcataaaa taagaagaaa tcccctgatt ccaggcggaa acaaaatttt 2776021 ccggatgcca cgaagacggc agcgaccagc tgtgctcaaa aatatcgtca gagtttttaa 2776081 aggcgctcat caccatccag agaagcggat aggcaatcgc aatcagataa agaaacagaa 2776141 aaacccacac agacgtttct ccgatatacc attttcgtct aggcttatct ttcacctcaa 2776201 tgtgctggtc aggcaccggc tccaatctga acgaatctgt cttcttctga ggcagcatca 2776261 gttactcctc ctttccggtt ttaaagaact tcatttgcat gagcgataat gcaagcgtaa 2776321 tgattaacac gacagtggca atcgctgagg cgtagcccat catatccttt gtaaaggcgc 2776381 ttttatataa aaacgtgctc aagacttctg acgcttttcc cggcccgccg cctgtcaaaa 2776441 tgtacggctc attaaagacc gtaaaggctc cggtcagcgt catgaccacc gcaacaaaag 2776501 acatctcttt cgtctgggga acagtaatat gaaaaaactg ctgaatttta cccgcgccgt 2776561 caagccgggc cgcttcatac agttcatccg gtattttttg aatcgacacg atgtacagca 2776621 tcgcaatata accgacagat tgccactggg acacaaaaat gacagaaagc atagctgtgc 2776681 tgtcatcccc gagccaggcc ctcgtcagct gatcaagacc gatggcctga agcagctgat 2776741 tcaaaagccc tgtctccgga ttgtaaataa aatcaaacaa aagcgcgatc accgtcattg 2776801 agatgacaac cggcaaaaag aaaacggtac gaaaaaacgg cgaccatttt ctgaccagct 2776861 tatcctcaag caccgccgcc aaaatcaaac cgccaaatac ctggcataca attgagatca 2776921 ctgcataaag cacattattg gtaagtgcct gatagaagac aggatcatga aataattcaa 2776981 catagttttt taagccgata aacgtttttt ccggagaaaa tgagctccac tgaaacaggc 2777041 tgaggaatac attctcaaaa atcgggatat aaacgaaaag taaaaaaacg agagcgggca 2777101 ccaaaaacaa ataggggatt attttattct gattgaccaa gggtatctca tctcctttat 2777161 aaaaagaaaa ggtgcgaagc ttcacctttt ctttgattta ttcagctgac gccctcacct 2777221 gctttgctgc cttttgaacg gctttcatca cctgctgcgg tgtcatgtcg ccgccaagca 2777281 tttgctggac gcccgttagg tacgcatctg cgacttcaac atcgacatcc atatcaaacc 2777341 atggaaccat tgatttggca tcaacaatat gctgaacggc ttcacgctga atggctgttg 2777401 cattttcttc agtagccgta ccttgcactg cactgtattt cccgacatct ttcacgagct 2777461 tttcgcccat tcttttcgac gtcaagaact gcaaaaattc catcgcttcc ttcggatgtt 2777521 ttgttcttga ggagatcatg aatccttccg gcgctcccgt taacgcttct gaagatcctt 2777581 tctgcccgct gatttcagga aatgggaaca tcccgagatt aaccggttca accagcttga 2777641 tttccgctgt ttccgcatat atcatcgccg actttccgct cttaaattgc tgtctcacat 2777701 attcgtggtc gacggagttt acatgtttat taaagtaagg catcagctct tgaagctttt 2777761 caagtgcttt tacgtagcct tcatcagtaa attcacccgt tttggcgtta tagtcctttt 2777821 cccgtgtttt ttcatcgacc atccgctgat taagcgtgcc gatatagtgc gagattgtcc 2777881 aagtcgcctt tgttccaaag ctgatcggtg tgtagccatg ttctttcagc ttttttgaca 2777941 catcgattaa ttcatcccac gtcttcgggg gatcaagatt cagcttttgg aaaatgtctt 2778001 tattatagaa gaatgattta gcgtccattt gccacggtac gccatattgc ttgttttcat 2778061 aagtaaatgg tgtaatttgc gattgaacga gctgtgatga ccaatcggtg tcatttttgt 2778121 agtaggacga gagatcaagt gctttattgc ctctgataaa tttaaaagca aactcatcgc 2778181 tccaagagaa gtaaatgtca ggagggctgg tggttcccag catgacctta attttatctt 2778241 tataggagtc atttaaaacg gcttcaattt gaatgtcgat atctgggtga tctttttcaa 2778301 attccttaac aacctcttca aaataacttt tttccggctc ctttggccat ctgtggaaaa 2778361 atttcaatgt cacctttccg tccgctgaac tgctttggct cgaacagcct gcgatggtga 2778421 gcatactgac agctgcaatg atcaagaaca acaacatttt cttcaaaggg ttggcctcct 2778481 ctggacatta gactataatg ttatataaca ttatagtcta atgcataatg gttcttcatt 2778541 ttcagatcaa tactcaactt tccacatgta tcttctatga gataaaggat gatttctctc 2778601 ctctgccagc tcgtctgcat agcttctcag cacacgattg agaacgagcg gagcaagata 2778661 gcctttaact gaatcgtcaa ttgcagtgaa gtcgtaagat gcagcatcaa gcacagtgag 2778721 ctttttgcca tactttttcg agaaggtaag cgcccgctct tcaagaggtc ttgtttcatc 2778781 taaaccgagc aggatgataa acggcacgga ttcatcaata atttcaaacg gtccgtgaaa 2778841 atattctccg gcatgaatgg cgtgggaatg aatccattgc atttccatga gaatgcagat 2778901 gctgtaggag taagcgacac cgtagtttgc accgcttgcc atggtataaa taatgctttc 2778961 tttttcatgg gcttttgcaa attgcttggc gttgtcagct tcctgcttaa gggctttttc 2779021 atatacagcc tgcaattgat ctaagccttc aattgcttgc tcaaatttcg tattgttttc 2779081 taatacttgc agggttccaa aaacgatttg atacaaaacg ccatagtttg tattgatcgc 2779141 aagcgcctca tcaccccaat cgtactgggc aacatattgc gcttcctgcg ctaaaggaga 2779201 ctccggttta aacgtcatcg caatcgtaag tgcgcccttg ccccttgcaa acgcagcagc 2779261 tttgactgtc tccggggtat ttcccgaatg cgagcacaaa ataacaagag acttttcacc 2779321 aagctgaaca gggttgcgct gaataaattc gttggcgctg tagagatcgg agtttattga 2779381 ttttgactct ctgtcaaaca catacttact cggatacata atggcagaag accctccgca 2779441 tgcgacaaag aatacatgat caatggtttt ccctttcaaa tcctgcaaga aagcttgaac 2779501 ctcacgattt acttttgctg tggcctgact caaatccttc actcctcgtt tttattatat 2779561 aacgttatat aacattatat attgttatat taaagtccgc gggtaggatt gtcaatatta 2779621 ttttctgaaa tttctcaata atttattcgg atgacagaca aagggtctat atgcgaaaaa 2779681 atgcccaaat caaaagccag aacttgactt aagctctggc ttcgctgttc aatccgcaga 2779741 ctgacgtctt atttaaaaaa taccttgtct atattgtact tcgagtgctg tgtattgatg 2779801 atatatgttt cgtaaatctc tctttccatt ggatcatcaa ctacacatac ctcaatttta 2779861 taaacttcat ctctgtgatg tttgatcggt gaaacagtgt cttcgaaatg cttcttaatt 2779921 ctctgtctta actttctggc tttaccgaca aacagcagct cgtcatgaat gttgtaaaac 2779981 ataaaaatgc cgcctttgtc ccttgggatc tggtgaaagt cgatgaatcc gtgaatcggt 2780041 tttatcttcg gctcgttatc attagctgac tgctgtcgtt cagtgatggt gacattcggt 2780101 gcgggtatat caatttttat caaaatcagt tcacgtcctc tttttcatta aagataaatg 2780161 ctaacacata cagaaaagaa aagctagaac agctttatta tatttgtttg tcatgctctt 2780221 acttattatg caagtgctcc ggctggatca taaggactaa ggtctaattc tgtctgcttt 2780281 ccgagaacta gctttgcgag ctctgcaccc aaaaacggcc ccatcgtcag tccagaagca 2780341 cccaaaccgt ttgcagcgta caggccttga acattcggca cggcccctac gaccggcaga 2780401 aatcccggtg taaacggcct gaagcccact cttgtttcaa cagcagccgc atcagcaaga 2780461 cccggtgcaa cggctaacgc tttgctcaat acttcgtgct ggcctccggc tgtcacacga 2780521 agatcatcaa gaccggcatc gttttcgtgt gtggcgccgg ctacaattct gccgttatca 2780581 aacgacagaa tgtactgatc actcggcggc attacaaccg gccacgatcc tgtatctgca 2780641 tctgtcattt caaaatgcat aatctgcgct ttttgaaatg acacttgaaa atgaatgcca 2780701 agaggcttca atatctcatt ggcccatgct cccgccgtca caatgaccgc gtcagccgca 2780761 aactgctttg tatctgtttg cacgccggtg actgttccgt tttcaaaaag caaggacgca 2780821 tttcctttga tgaccgttgc gccgcgtttc tctgcagcgc ttaaaagcga ccggcacagc 2780881 gctcttccgt tcacacgggc ggcaccgctg atatgaaccg attcatagcc gtcagctaaa 2780941 atcggaaaca gctttttcgt ttcacttgca gacaagcggg taatgtcgcc gatttccggc 2781001 gcatcctccc gtctcttata cgccctttcc tccattttat cgagtttaga cgcgtcagta 2781061 tgaatgctga tggcaccgac acgtttgtat cctgtatccg attcaccgtc tttttccaat 2781121 tgatggatta aatccttata gtaccgcgct ccccccttag caagctggta ccaatcctga 2781181 ttacggcgct gcgagagcca aggacagacg atccccgccg ccgcatcagt cgcttgtccc 2781241 ggctctttcc gatcaatgac agtaacgcga gcgcctgttt ttgcgagatg ataagccgtc 2781301 gacgcgccca gaatccctgc gccgacgatg atgtacgatt tcatatgcaa acaccttttc 2781361 tattataatg tctattcatt ttaccaaatc aaatgctttc cttcgacctt ttgccctaat 2781421 gtggaaaaac cgcgaagttc gtccaatctc tttactctcc tatcgaatat cctgtcacta 2781481 tcaatagaga aaggatgata ccatgagcga aaatcgtcat gaaaatgaag aaaacagacg 2781541 cgatgcggca gtggcaaaag tccaaaacag cggtaatgca aaagtcgtgg tcagcgtgaa 2781601 cacagatcag gatcaggcac aggcgcagtc acaagacgga gaagactaat gaacgaaaac 2781661 atcattcctc ttaacagaca tactcaagag atacccacta ctgaatctgt tatcaaaaac 2781721 agcggcaact cagaggtcca tatcgacatt cacattgata caatgccaat tgcttttgct 2781781 atattatgct ctgcattagc cgcaaagcag atgacaaaag aggaattcga tatggcttat 2781841 actcaattgc gagagatgaa cagagaaaat aacagcagat catctgtaaa gcaaattatc 2781901 aatcaagaga cagaagaaga gtaaaaaacc gcggcccctc ggccagcggt ttttcttctg 2781961 catacaaaaa ggacgcgact gaatcggtta cttctgtaca atttgaataa ggttaccgca 2782021 tgtatcgtcg aagacagcta ttgtgacttc gcccattttt gtcggttccg tcgtaaacgt 2782081 cacgcctttt tcctttaatc ggttgtactc tttttgaata tctgcaacgc caaacattgt 2782141 ggccgggagg ccttcggaga atatcttctt ttgatactcc ttggcggcag gatgttcatt 2782201 cggttcgagt aaaagctcgg ttccgtcttg atcatctgga gaaacaagcg ttatccacct 2782261 gaatttcccc atgggaacgt cttccttttt tataaaccca agtttttctg tataaaactc 2782321 cagtgccatg tcttgatctt gtacaaatat actggtaaca acgattttca tactgttttt 2782381 ccctccttcg atatgaatga agcatggtac tatgctaaca atctggctac aagcaaaaca 2782441 acccacacat ttatcagagg ccctgttctg attttataaa attattctat ccatcctttc 2782501 agcaaatttt taagcggttc gttgttgaat ataagtactc gatattttcc ctttcgtttt 2782561 gatgttacga gtcctgcatc ctccagtaca gaaaggtgtt tagctatcgc ctgtcgcgta 2782621 atagaaaggt cgtactttgt aataagacgt atcgtaagtt catacaacgt cagctcgttg 2782681 cgttcagata attcgtctaa tataagccgc cgagtcgaat cgccgagtgc tttgaatata 2782741 gcgtctttgt tcccattcat atattgagta taagcaaccc attagttgca tgtcaagtat 2782801 aagcaactgt atggttgcgt gatatagaaa ctgaacctat ccggcgcagg tctgaaatat 2782861 tctaatcgat aaggaattaa aaccattaaa ataacagtgg atatgtctct gaaaaataaa 2782921 agaagacgaa cttcaaaagt tcgtcttcta caatcaaatt cggcacgccg gccattttaa 2782981 agttgataac tatctctaaa ccccttgata aacaaaggag ttttcatcat taaccgatag 2783041 aaccttccat ttcgaactta atcaaacggt tcatttcaac tgcgtattcc atcggaagct 2783101 cttttgtgaa tggctcgata aagcccatta cgatcatttc agttgcttct tcttcagaaa 2783161 taccgcggct catcaagtag aagagctgct cttcagatac tttagacact ttcgcttcgt 2783221 gctccaatga aatgttatca tttaagattt cattgtaagg aattgtgtca gaagttgatt 2783281 tgttatccat aatgagcgta tcacactcga tgttagagcg ggcgccttcc gctttgcgtc 2783341 cgaagtggac gattccgcgg tacgttactt ttccgccctg ttttgaaatc gattttgata 2783401 cgattgtaga tgatgtgttt ggtgcaaggt gaatcatttt cgcacctgca tcctgatgct 2783461 ggcctttacc cgcaagagcg atagaaagcg tcataccgcg cgcgccttcg ccttttagga 2783521 tacaagccgg atatttcatt gtcagcttag aaccgatgtt gccgtcgatc cattccattg 2783581 ttgcgttttc ttcacagact gtacgctttg ttacaaggtt gtaaacgttg ttcgcccagt 2783641 tttggatcgt tgtataacgg cagtagccgc cttttttcac gatgatctca acgaccgcac 2783701 tgtgaagtga gtttgttgtg taaacaggcg cagtacagcc ttcaacataa tgaacgcttg 2783761 cttcttcgtc aacaatgatc agtgtacgtt cgaactgacc catgttctca gagttgatac 2783821 ggaagtaagc ttgtagcggt gtttcaacct tcacgccttt aggcacgtag atgaaagaac 2783881 cgccggacca aacagctgag ttaagcgccg caaacttgtt atcagtcggc gggattactt 2783941 ttgcccagtg ctcacggaaa atatcttcat tctctttcag cgcgctgtca gtgtctttaa 2784001 agacgatgcc ttgtgcttca agatcttctt tcatgttgtg gtatacaacc tcagattcgt 2784061 actgagcaga aacacccgca aggtattttt gttcagcttc aggaataccg agcttgtcga 2784121 atgtttgttt aatttcttca ggaacttcat cccaagaacg ctctgaacgc tcagacggtt 2784181 ttacgtagta cgtaatttcg tcaaagttca gtgagtttaa atctccgccc cattgaggca 2784241 tcggcatatt gtagaaatgc tcaagtgatt tcaagcggaa gtcaagcatc cattgaggct 2784301 cttctttcat gcgagaaatt tcttctacga tttcttttgt caatccgcgc tctgaacgga 2784361 aaatggaaac gtccttgtcg tgaaaaccat acttgtattc accaatatca ggcatttttt 2784421 tagccatcca ttttcactcc aatcctttta attgccgcct tcttctttcg cgactccttt 2784481 ttcaagtgct ttccatgaca gggttgcaca tttgatacgg gcagggaatt ttgaaacgcc 2784541 ttgaagggct tcaatatccc cgagatctat agaatcatca tactctttcc cttgcatcat 2784601 atccgagaaa atcttagaca tggaaagggc agtttcaata tctttccctt taatcgcctg 2784661 agtcatcatc gaagcggatg ccattgaaat ggaacagcct tccccttcaa acttcgcatc 2784721 ttccacgatg tctccgtcaa gcttcattgt cagtctgatg cggtcgccgc atgtcggatt 2784781 gttcatatcc acgacaatgc tgtcatttaa aaccccttta tttcgcgggt ttttgtaatg 2784841 atccataatc acctgtctgt acaatgtatc taagtttgca ttaaaagaca tttgtaaaat 2784901 actcctttgt cttttgaaga gcttccacaa gcttatcaat ctcttcctct gtattataca 2784961 gataaaagct tgctcttgca gtagcagtta catccagcca tttcatcagc ggctgcgcac 2785021 aatggtggcc ggctctgact gcgattccct ccgcatcaag cacagtcgcc acatcgtgcg 2785081 gatgaacatc atcaaggtta aatgtgacaa gcccggcacg ctcttccggc ccgtaaaccg 2785141 ttacgccgtc aagctggcgg aagcgttcaa gcgcataagc tgcaagcttg tgctcatggc 2785201 gggaaatctc atcaagaccg atttcttcga gaaaatcaat ggcggcaccg aggccgattg 2785261 ctcctgcaat aatcggcgta cccgcttcga atttccacgg aagctctttc caagttgatt 2785321 cataaagccc gacaaagtcg atcatttcac cgccgaattc ggcaggctcc atgttttcca 2785381 gcagggcttt ctttccgtac agcacaccaa caccggtagg tccgcacatt ttatgggaag 2785441 aaagcgcaaa gaagtcgcaa tcgagatcct gcacgtcaat tttcatgtga ggcgtgcttt 2785501 gtgcaccgtc caccacaatg acagccccat tgtcatgagc gattttcgcc atttctttaa 2785561 tcgggttgac cgtgccgaga acattagata catgagacac cgcaacaatt tttgtgttgc 2785621 ttgtgaccgt ttctctgacg tcttctaaag aaatcgttcc gtcttcctgc aacggaatat 2785681 attttaatgt ggcgccagtt gcttttacag cctgctgcca cggaatgata ttcgcatgat 2785741 gctccatgta ggtgatgacc acttcatcac caggtttcag gttggcgcgc gcatagctta 2785801 acgccaccat attcagtgat gtggtcgtgc cttttgtgaa aataatctca gccattgact 2785861 tcgcgttaat aaacttgcgg actttttcac gcgctccttc ataaccatct gtcgctctgg 2785921 ttccaagtgt atggacgccc cggtgaacat tggaattgta ttggttataa tacttatcca 2785981 gtgtttcaat gacagcacgc ggcttctggg aagtcgccgc gctgtcgaga taaacgagat 2786041 catgtccgtt cacttgctga tgaaggatcg ggaactgttc acgaatatct gtgatattca 2786101 ttacttcact ttcctttcga taacagaaac taattgtttc ttaacgcctt caatcggaag 2786161 ttcatttact accggtgcaa ggaatccgta aatgactaag cgttctgctt cttctttcgg 2786221 aattccgcgg ctcatcaggt agtaaagctg aatagggtcc acacggccga cagatgccgc 2786281 atgtcctgca gttacatcgt cttcgtcaat taaaagaata gggtttgcgt ctccgcgtgc 2786341 tttttcgcta agcatcagca cgcgtgattc ttgctccgca ttcgctttag aagcgccatg 2786401 ttcgattttg ccgattccgt taaagataga agaagcggaa tccttcatca caccgtgctt 2786461 caagatatag ccttcagaag ctttaccgaa atggatgatt tgtgttgtga agttttctgt 2786521 ttgctctcct cttccgacaa caaccgtttt cgtatcgccg tatgtgccgt caccgtaaag 2786581 gtttgttgtg ttttcggaaa tcgtgtcgcc atcgttcatc aggccgagag cccactcgat 2786641 tttgctgtcg cgtccgcgcg cagcaccgcg gcggttcaca taagttgtca caccgcttga 2786701 cagattatcc accgcaccgt atgtcacgct ggcattatca cctgtgatga cctcactgat 2786761 aatattgaag acagcgtctt tcgggtttac agtgctgatg tagttttcta catatgttac 2786821 agagctgtgg tcttcagcca caatcagcac gtggttgaat agagctgtat cattgctttc 2786881 gtggacataa acagcctgaa ccggcgtctc cacctgaaca tttttcggaa cataaaggaa 2786941 tgctcctccg ttaacaagag ccgcgtgaag tgcagttaac ttatgttcgt caaccttcac 2787001 gccgtccttc ataaagtatt tctccaccaa gtcgctgtgc tcgcgtgcag cagtcagaat 2787061 atcagtgaag atgacgcctt tgtctttcaa ttcttgagaa agagaaagat gtgccggcgt 2787121 ctggtcacgc tgtacgtata atgttttatc ttcgttttca atgtcgatca gcgcttttac 2787181 ttcatcagtc aaatcttcta atgaagaaag cggttcgtta tccactgtat gcttcgcgaa 2787241 attcgtgaag ttccagtttg tgatttttgt tttgtcaggt ttcggcatcg gcagatcctc 2787301 agcttgttca agagcctgta agcgcaggtt cttcagccag gcaggttctt ggtgcttttc 2787361 ggaaaagctt ttgagatact cctgatctac ggatagtttt gtacctagtg tcatattaat 2787421 ccccctaacg cttacgcttc ttggccaaca gtttcgtctt caatgccaag ttcttgtttg 2787481 atccagtcat aaccttctgc ttcaagacgc tgtgcaagct ctgcaccgcc ggattttaca 2787541 acgcggcctt gcatcataac gtgaacaaca tccggagtga tgtagtttaa caggcgctga 2787601 tagtgagtga tcatcaggca gccgaagttt tcgctgcgca ttttgttgat cccttttgat 2787661 acaactttca aagcgtcaat atcaaggcct gagtcaattt catcaaggat ggcgattttc 2787721 ggttcaatca tcattaattg aaggatttcg ttgcgttttt tctccccgcc tgagaagcct 2787781 tcgttaagat agcgctgagc catttcaggg tccatttcaa ggaactccat gttttcgtcc 2787841 attttgcgga tgaatttcat gagagaaatt tcatcgcctt cttctctgcg cgcgttgatt 2787901 gctgagcgaa ggaagtcggc atttgtcaca ccgctgattt cacttgggta ctgcattgca 2787961 aggaataagc ctgcctgcgc acgctcgtcc acttccatct ccagtacatc tttgccgtca 2788021 agcgtgatgc tgccttttgt tacttcatat ttaggatgcc ccataatagc agctgataaa 2788081 gtggatttac cagttccgtt cgggcccatt actgcgtgga attctccacc ttttatttca 2788141 aggtttacac cctttaagat ctctttccct tcgatttcaa cgtgaagatc tttgatcgtt 2788201 aatgttgaag cagccatatc tatacctcca aaaatatata atcattattc tcattttatt 2788261 ctcattctaa ttttataaca aatgaaaagt aaatacaact ttttatcgtg ccttgcacat 2788321 tcctcaagtt taacaaagat cagcacttta ttaaagcgat tgaaaaagaa aaagagtgga 2788381 ttcccaccct tttttaaaag attgattttc tcaataagct cccgcagaaa tccgcttgct 2788441 tttttcataa tcaagctctc tctgccgctc tactttcatt cttgtttcca gccggcgtcc 2788501 atattcctcg tatccaattc cgtgtgacag ctgcatcgct ttttccattt ctgacgtata 2788561 atcgaggttc agtctgtcct ggctgctgca aataatgaat caatcccttc atatatttgc 2788621 tttttattgt accagtgctg cgttggatgc cgcaaaaacg atttggcgtg aaatagcggc 2788681 agatgagacg aaagcatcct ttcagaacaa atgagaatgg tttttcggaa tattccttct 2788741 cttaatgcgt ggtgtttccg aattcctcaa tgcactgttg aacgactgtc acgccttggc 2788801 tgaaagctgc gccgcctcca aatgccgctg ccacactgac ggcttcgaga atgttttctt 2788861 ctgacgctcc ctgatcaaga cagccttttg tatgatagat catgcaatat tcgtcctgag 2788921 cattgatggc aattccgagg gcgatcagct gtttttctct ttcagtcaga gaattcccgg 2788981 caaagcactg ttcagtaaat tcgttaaatt ttcttcccat cagcggcatc ttttgttcaa 2789041 atgtgcctaa accatgttta tattgtttta acgcgtcctg catgcttcct ctgtcttgat 2789101 tcaaagaaaa tccctccatc tgtttaacat tcctttttat tatgaacagc ttttaggaaa 2789161 atacgcgaaa aaaaccccgg aattctcatc cggggtttca gtcttattca gatacaggaa 2789221 gcacagctcc gtcgtatttt ttctcgatga agtctttgat ctttttagag tgaagaactt 2789281 ccatcagcgc tttgattttt gcagaatctt cttcgccttt tcttactgcg atgatgttag 2789341 cgtatgggtt gtttttcgtt gattctactt caattgcgtc ttttttagga tttaatttat 2789401 tttggatcgc atagtttaca ttgatgaaga ccgcgtctcc ttctttgttt tcatatgctt 2789461 ttgccgttaa ttcaggcgct acttttttga attcaaggtt tttcgggttt ttcttaatgt 2789521 ctttcaatgt tgcgtcaact gtttccactt tagaatcaag agtgattaat ccagcgtttt 2789581 caagcattgc aagcatacgg ccttgttcag caacgttgtt tgtcagaatg attgtcgcac 2789641 cgtctggaag gtctttcagt gatttgtatg ttttagagta aataccgaat ggctctaagt 2789701 gaacagcgcc ggcattcaca agtttgtaat ctgtgttttc tttcatttct tgctcaaggt 2789761 aaggaatgtg ctggaagtag ttcgcgtcca cttctttatc agctaaagct ttattgtaca 2789821 ttttgtaatc actaagcact ttcactttca gcgtatagcc tttttctttc agcaatggtt 2789881 cagcttcttt taaaatttcc gcatgcggtg tttttgttgc cgcaacgaca atttctttct 2789941 tgccggattc agcgccgtta ttcgaaccgc aggcagccat aactcctgca aatacaagca 2790001 gtaatgcacc caaaaatagc tttttcaatg taaatcctcc cttatcgttt gtctataata 2790061 tttgttatta gatcaccgat gatttgaata ataaacacga tgattaaaat aaacacagta 2790121 gcaacgaagg taacatcagc gttattagac tgatatcctt ctacgtacgc aaggtttcca 2790181 aggcctcctg aaccaatggc tccggcaatt gccgttgaac cgattaaagc gatggctgta 2790241 accgtaatgc cagaaataag agcaggcatt gattccggaa tcagcacttt gaaaataatc 2790301 gtagacgttt tcgcgcccat tgatttagct gcttcaatca cacctttatc cacctcacgc 2790361 agcgcgattt caacaaggcg cgcgtaaaat ggtgccgagc cgattaccag cgccggcaat 2790421 gcggcgtttg gccctaagat cgtgccgact aaaaatttcg taaaacctaa tagtaaaata 2790481 attaaaataa ggaacggaat cgatctgaat atgttaacaa cggctgcaat cactgagttg 2790541 accgctttat tctgccagag gcttcctttg ctcgtcagaa agagcagcaa gccgaggatg 2790601 accccgatga caaaagcaaa cagtaaagaa atcagcgtca tataaagtgt ttcatatgtc 2790661 gcgttccata attcagttaa atcaacgttc gggaagtatt tttcaaacat tcgtgatcac 2790721 ctctgctttc acctgtttgt cattaatgaa tcggatcacg ttttgcactt cttcctcgtc 2790781 cccgtcaatg tggatgaaca gtgaaccgta agccccatcc ttcgtctgcg aaattttccc 2790841 ttgcagaata ttgacgctga cattgaagtt tctgatcatc tctgtaatca gaggctgttc 2790901 agctgactca ccgacaaatg tgagctgaac catttttcct gatgctgtat catcaagaag 2790961 gtgctgaagc gtctctttcg tttcttccgg ctctgtcacc tgttgaacaa atcgttttgt 2791021 catttgttcc tttggatttt tgaagacatc gagaacctcg ccttcttcga ccaccttgcc 2791081 gttttccatg acggcgactc tgttgcagat tttgcgtatg acatgcattt cgtgcgtaat 2791141 cagcacaatc gtcaaaccga gtctttcatt aatatcggac aatagatcca gaattgaatc 2791201 tgtcgtttgc ggatctaatg ctgatgtcgc ttcgtcacaa agaagaacct tcggattgtt 2791261 tgcaagcgct ctggcaattc cgacacgctg cttctgaccg ccgctcagct gggacggata 2791321 agatttttct tttccttcta aacctaccag tttaatcagt tcattggcgc gcttgatccg 2791381 ctcgctcttt ttcaccccgg caatttctaa aggaaacatg atattatctc tgacagtccg 2791441 cgaccaaagc aaattgaaat gctggaaaat catactgatc tcatggcgtg cttttcttaa 2791501 accgcgtcca tttacttcat taatcttggt tcccgccact tccacggttc ctgaggttgg 2791561 tttctcaagg ccgttcagca gacggattaa ggaactctta ccagctccgc tatatcctat 2791621 aattccaaaa atctcacctt ttttaatgga aagcgagacg ttttggacag cattgacatc 2791681 tccatgtttc gacttgtaaa cttttgaaac atcctgaaga ttgatcaaag caatcacctg 2791741 ccttaacact attctaagaa atcttccggt tttttctgca aaagaaaagc ctttctgcac 2791801 acttgagcag aaaggcttat ataaaatgcc tttctctcat ctttcaaagc tgaacgcttc 2791861 gtgtgaattg gcaccatttc aacagtgttg atggttgccg ggcttcatag ggcacttccc 2791921 tccacctctc ttgataagag aaatatatag tctttttcgt ccggaaattc ttaatgtaga 2791981 atagcacggc gaatgattaa atgtcaataa aataaatgat gtcaactttt actattataa 2792041 taatttatta ttttttaatt ttttaaaatc ctctgaaaaa atccatttgt cagccagaga 2792101 atggcttcca gctttaacag ggccctgaat gaccccttta ctttgaggct tccgctctga 2792161 ataaggtgct gaagggaaat gtctccgtgc aataaatcaa taatttccgt ttggtttccg 2792221 taaaaggtca ggttggacgt ttggggcgga gaaacttttt tcatttctcc ctgttcgttt 2792281 attgagacgg ttaaggcttc tgcttctcct tggaaggtaa tgagcaatgt tgaggcattc 2792341 aaaaggggtt ttaaaaacag atgctgatac tcatcttcta aaacttccgc tttctccata 2792401 tgtacaacct cctatttgtt ggtcatacat acacatttct ctctttgtcg caagaacccc 2792461 tttataaaac gaacgacaat ttcattggat atgctgagaa atatgtcata aatgggatgc 2792521 ggaagatgat ttttgtttga tcagctcata taaataagaa acggaatgaa atgcatatcc 2792581 tctttcgacc atctttccgc ctttaaacag cagaaaacaa gggacgcttt caatttgata 2792641 cgcttttgcg aatgtcggag agtaattgac attgttttga tagaaggcga catccggcag 2792701 catttctttc accactgtca gcattttgct tgcaagctgg caggtgccgc aaaacggagt 2792761 atataaatat agaaggtaca catcatcttc aatgtgatca agttcgtgtt cttggagttc 2792821 tttcatgcta tacacctcgg gactttcttt caagaaaaat agtatggaca ttcagattcg 2792881 cacgcagcaa tacagaagcg atatggtgcc tgggcgcagc cgctacttcc ttataggctc 2792941 tgtcgacatg gagatggcag gcttcattaa attcacgctt cagctgtttt ctcaatttct 2793001 cacctgattc atcagcatca actaatatat agacgtcttt atcataaagc tcgtcagcca 2793061 attcctcgag cctcagctgg ctgattgttc cgtttgtgca gataatgcgc atcggttcat 2793121 tcaggacgct ttcgattttc tctttatctg atttcccctc gacaatcata accttttcca 2793181 gctcatccat cttcatcttg ttcacctgcc gcgtcaaatt tgaaatgttc agattgtaaa 2793241 agaaggcagt gaaattcacc gccaacatta acaccagccg ttttcgtagt cacaatctac 2793301 atattttgcg tcgtctccag agaccacatc ggctgtctta taaaatttct cattttcaaa 2793361 ggaataaccg gacttaagct catattcatt catgcttgtc atttggccga tcatctcatt 2793421 atcatgatat aacgagagcc ggccattttg aaagcggcct gtcacgtcat tggtgacatc 2793481 gagcttttgt ttgtcgaaag ccatattgga cacctcccat aacgttagcg tgtccaattg 2793541 cttttacggc tatcctgttt tagtcttctt gtgtcatctc ttcgtattgc tctgctgtca 2793601 tcagtttttc aatttcagaa gcgtcagatg gctcaacgac gatcatccat gctttttcgt 2793661 acggagattc gttgacgaat tccggactgt catcaagatc ttcgtttact tccacaaccg 2793721 ttccgttaat cggtgcataa agctcagata ccgttttaac ggattcaaca ctgccgaatg 2793781 gctcgtccgc tttgatttca gcgcccactt caggaagttc gacaaacacg atgtcgccta 2793841 gttcggactg ggcaaaatgc gtaattccga ttctggcttt ttctccttca acttttaccc 2793901 actcgtgttc tcctgagtaa cgcaaatctt ttggtatgct caattgaatc cctccatttt 2793961 ttacagcact acaataagaa gataccacac ttttcaaaaa aaatttacat taagcccagt 2794021 tttcttcaaa ttggtcttct ttaaatccga cagtcacttt ttcgccgtct gttgtaagcg 2794081 ggcgtttaat tagcatacca tctgaagcca gcagttcgag ctgttcgtcc tctgacatat 2794141 gatacagctt ttccttgaga ttgagctcgc ggtatttcat gccgctcgtg ttgaaaaatt 2794201 tcttgagatc cagcccgctt ttttcataaa gcgcttttaa ttcttctttg cttggcggct 2794261 gctcagcaat atgtatttcg tttatttctt tcccatgctc ttcaagccac ttctttgctt 2794321 tgcggcacgt tccgcattta gggtaccagt aaaaagttaa cgacatcttc ttccccctca 2794381 ataaaataat cgaggttatt ttaacacagt ttgttttaaa aacctaaaac agtgcttctt 2794441 aaaaaagagc tccgcgcatg cggagctcat ggccaatcag acagtatatt tctcagcctc 2794501 aaaaatgcct gccgccgcct cgcgtttttt ctgaatcacg tttttaggcg ttacgcgtgt 2794561 cagcttgcgc agagcggaaa gcatcatgcg gagtgaatct ccttcttcca ttgcgataag 2794621 ggattccttt gcatgcgctt cgatttcgtt aaaggcctct tgaacgaaaa tttctgtgta 2794681 cagcaccttt tgcgctgctt tttcagcgcc ttgtgcggca atggcctttt ccgttctgag 2794741 cacggctgat tccattgcgt atacattgct gacgatatcc gctacgttca cgagaatttc 2794801 ttgctcacga tcgatcgctt ttccgtattt ttgcgcggct aggccggcag caaacaacgc 2794861 aatttttttg gcttgcttga cgatatattt ctcctgctct aagacgccgc ttccaggctc 2794921 ttcaggcata agcatcatga gttcttcctg cagcgactgc gctttttcga ataaaggcag 2794981 ctcgccttta agcgcttttt tcaggaaggt gcttggcacg attaaccggt tgatttcgtt 2795041 tgtgccttca aaaatccgat tgatccttga atccctatag gccctttcta cttcgtattc 2795101 ctgcataaag ccgtagcctc catgaatctg cacgccttca tcaacgatat aatcaagcgt 2795161 ttcagagccg aataccttat tcagagagca ttcgatggcg tattccgcaa tcgatttggc 2795221 gatttgccgg ccgtccttga gatcttcggc cgtgaactgg ctcatattgt cttcaaacag 2795281 cccgacggtt ctgtatacag agctttccat cgcatacagc cttgaggcca ttgtcccgat 2795341 tttttcctgt gtcaatgaaa aaccagcaat cggcgtttta aattggcggc gctgatttgc 2795401 gtatgccgca gacagctcga tgacgcgttt agatgcgccg attgtgccaa ccgccagttt 2795461 gtaacggccg atgtttaaaa tattaaaggc gatgacatgc cctttgccga tttctccgag 2795521 caggttttcc tttggcactt cagcttgatc cagaatgagg gttcttgtcg atgatccctt 2795581 gattcccatt ttcttttctt ccggtcccgt ggagacaccc gggaactctt tttctacaat 2795641 aaaggctgaa aacttgtcgc cgtctacctt agcgtaaact acaaatacat cggcaaaagc 2795701 agagttggta atccactgtt tttcccctgt taatacataa tgggttcctg cttcattcag 2795761 cacagctgtt gtttttgctc caagtgcatc agacccagag ccaggctcag tcagagcata 2795821 agcggcgatc ttttcgcctg aagcgagtcc aggcaaatat tttttctttt gttcttctga 2795881 cccgaaaaag acgatcggca aggaaccgat accgacatgc gcgccataag aaagagaaaa 2795941 gcttcccgca cgcgaaaatt tctcagtgat gagtgccgag ctgattttat caaggccgag 2796001 cccgccgtat tcttccggca catcggcgcc aagcagccct agttcgcccg ctttcttcaa 2796061 cagtctgaca gaatgctcga attgatggtt ttcgatatca tctatatgag ggagaacatc 2796121 ttgctcgatg taatcctctg ttgttttcgc aatcatttta tgctcgtcag tgaaatcctc 2796181 cggtgtatac atttgatcgt atgtgacatc ctcgattaaa aatccgccgc ctttttgtac 2796241 gtcagccgct ttttttgcca tttgtttttc cccctttagc ataattcaaa tacaccggcc 2796301 gctcccattc cgccgccgat acacatggtc acgactccaa attgctcgtt tctccgtttc 2796361 atttcatgga tgagtgagag tgtaagcttt gtgcccgtac agccaagcgg gtgtccaagc 2796421 gcgattgcgc ccccgttgac attcactttt tcttcatcaa ttcccaattc cctgattact 2796481 tgaatggcct gtgaggcaaa agcttcattc agttcaaaca agccgatgtc ctgcagctga 2796541 agtccggcaa gcttcaaagc gcgcggaatc gcttccaccg gtccgattcc catcacttcc 2796601 ggcggcacgc cgcctaccgc aaaggagcgg aatttcacaa gcggcgccag gccaagagca 2796661 tcggcttttt cccggtccat cagcatgaca gccgccgctc cgtcactcgt ttgtgaggaa 2796721 ttgcccgcag tcaccgtccc gtcaacggaa aaggccgggc gcaatgtcga taagatgtct 2796781 gcagtcgttt gcgggcgaac accttcatcc tgagaaaaca caaactgttt ttccataggc 2796841 ttatggtctt ctccgatttc tgtcaccgtc acttcgacgg gtacaatttc atctttaaat 2796901 tttccttctg caagggcttt agcggcgttt tgatggctgc gaacggcaaa cgcgtcttga 2796961 tcctcacggg agacgccgta ttttttcgcg acttgctcgg ctgtgtgccc catgctcata 2797021 taatattccg gtgccttttc tgccaaagca aggttcggac gggtaacatg ccccatcatc 2797081 ggaacttgcg acatggattc tgctccgccg gcgatcgctg tatcgtaggc gcccagcata 2797141 attttttctg ctgcatacgc aatagactga aggcctgaag agcaatagcg gttaactgta 2797201 atcgccggaa ccgtgtacgg caggcccgcg agcgcaccga tatttctcgc catattaagc 2797261 ccctgctccg cttcaggtgt tgcacagccg ataatcaagt catcaatatt gccttcgtag 2797321 ccgcctgccc gtttcagcgt ttcttttaca caaatcgctc ccaaatcatc cgggcgaacg 2797381 gtggccaacg atcctttttt tgcttttcca accggtgttc ttgcacctga cacaatgact 2797441 gcctctttca taagctccct cctaattccg taaaggttta cctttcacaa gcatatgctg 2797501 cattctcgct tgagattttg cctctcctga caaactcaaa aacgcttctc tttcgatctc 2797561 caataaatac tcttcatcaa cctctgtacc aaacggcact tttccgcccg caatgacata 2797621 agcgagtttt ttcgcgatct taaaatcatg ctcagatata tagccggaca gcttcatctg 2797681 ctcagcgcca agcaagagtg ccgcataacc ggtttctccc ggcaccttga ccttttcttt 2797741 tacaggcggc cgccagccgg tatcgtataa agatgcggcc agctgcttcg catcgtataa 2797801 caggtggtct tgattcacgc tgatctgatc cgtttctttt aagatgttca tctcacgagc 2797861 ctcttgagcg gaagcggaca ctttcgccat cgcgattgtt tcaaatgttt tcattgccgc 2797921 attcatcgga tcatggccgc ggcgaagatg gttgatgtac agctctttgt tacctcctcc 2797981 gccagggatg aggccgacac cggattccac aagtcccata taggcttcgc ttgccgcttg 2798041 aatgcgcgcc gccggcaggc atgcttccgt tcctccgccg agcgtcatgc caaatggcgc 2798101 ggcgacgacc ggtttcgcac tgtatttgat cttcatcatc gtctcctgaa aacggcggat 2798161 cacaaaatca acttccaaaa agttgtcatc ttggacttcc attaagatca tggcgagatt 2798221 cgcgccgacg cagaaatttt tcccttgatt gccgatgaca agccccttgt aattccgttc 2798281 tgtttcctct aatcctttgt ggatcatttg aatgatatcg aggccgatcg cattgctttt 2798341 cgaatgaaat tcaagaaggg ccacatcatc tccaaggtca attaagcttg ctccgctgtt 2798401 tttcgcaatc acgccttttg tttctttaag tgcttgtaaa tgaattcgtt ttttgttttc 2798461 tttcacggct ctgtattcgc cgcggtcata ataaaatacc gttccgttct ctttgatgta 2798521 gaaggtttca tttcctttgt ccagcatctc ttttatccag ccaggcatat ctgctccaag 2798581 ctgctcaagc ttttccgctg actgcttgag gccgatggcg tcccacatct caaaaggtcc 2798641 cagttcccag ccgaatcccc acttcatggc ttggtcaatc gcatgaatat catcggcaat 2798701 ctcgccaagc agctcggctg agtaaagcag ggtttgagaa gtgatattcc acagcaaacg 2798761 gccggccctg tcatccgaat aaataagcgc tttcattttg gcttttgtcc cttttgcctg 2798821 ttttgccgct tcaagtgccg gtgatttcat ttttgtccgc tcgccgtaag taagcgtcac 2798881 tgggtcaagc tcataaatcg tttttccttc ttttttataa aagccttggc cggccttgct 2798941 tccgatccac cctttttcca gcatatcgtt catgaagctt ggaatgcgaa acacttcttt 2799001 ttcatcgcca tcagctttgt catacacatt tcgggcaacg tgggcgaatg tatcgaggcc 2799061 gaccacatca agcgttctaa aggtggcgct tttcggcctg ccgatcagcg gtcctgtgat 2799121 cgaatcaacc tccccgacct gataaccgcc tttcagcatt tcttggactg tcacgagaag 2799181 cccgtaagtc ccgatgcggt ttgcgataaa gttcggtgtg tcctttgctg taacaacgcc 2799241 tttcccgagg acattttctc cgaaagctgt cataaacttt aaaatatcag gatccgtttc 2799301 cttaatcgga atgatctcta gcagctttaa atatcgtgcg ggattaaaaa aatgcgttcc 2799361 aagaaaatgg gctttaaaat catccgaccg gccttcagcc atttcctgca ctgatatgcc 2799421 ggatgtgttg cttgagacga tgcttccagt ctttcgatgt tcatccacaa gagcgaaaat 2799481 tttctttttg acttcaaggt tttcgacaac gacctcaata atccaatctg cttctttcag 2799541 tttttctgca tcatcctcca gattgccagg tgtaatatag gaggtatttt tcgctgatgt 2799601 gaggggagcg ggcttttgtt tcagcagttt tttcatcgcc tgccggctca gcctgctgcg 2799661 cacctccgaa ctgtccttcg tcagcccctt tttttcctct tcctttgtca aatcgttcgg 2799721 cacaatatct agcagcagga caggaattcc gatgttagcc aaatgcgccg ctatcccgga 2799781 acccattacc cccgatccta aaacggctgc cttccgaatg tgtttgtgca tgagatatcc 2799841 cccttgaaca ttgaatgaat agtcattcat tttttgacta aaaaaaatga aacccgtttc 2799901 ttctttcatc ttaaaagatt tccggttcga cttcaatagc taatttgtta tttttttgta 2799961 tgaagcctat aaaagtcggg caacttaagc ccggaggtga agggaatggt acgagagaaa 2800021 aaaaatccgt cttcagcggc agtcagcgcg gcgagcgtaa agggagatgc cggtccgact 2800081 cagcattacg gcggcggaaa acggacaagt caaaatcagc agtataaaaa acataacatg 2800141 ggacaatcat aatgcagctg cttcccacgg ctgctttcac tttttcaaaa ttccttttaa 2800201 cacaaacgct gcattggcag gccgttcggc aattcttctc ataaagtagc tgaaccagtc 2800261 cgttccatat gggacataca cacgcattct gtagccttcc ttggcgagtt ccttctgacg 2800321 ctccggcctg atgccgtata gcatttgaaa ctcaaattgc gatgcgggga tttgatgttc 2800381 ggcgacgagc tgtttcgtaa atgcaatgat gtcatcgtca tgtgtggcga cagccgtgta 2800441 gttcccgctt aacaactgca gctttattaa gctctgaaaa tgaaggtccg tgcctctttt 2800501 gtcgggaaac gctacagccg cagattcttt ataagcgcct tttacaagtc tgagattcgg 2800561 ctttaagtcc cgcatctttc tgatatcttc tgccgcccgg tacaaatacg cctgaatgac 2800621 cgtgccgagc ttctcaaatt cctgtttgca ttgcctgtaa atagaaagtg tctgttcata 2800681 atgagaatag tcttccatat caatggtcac agcaacatca tattgcttcg caacggaaag 2800741 aatggcgcgc aaatgagtaa gagcaagttc ttctgaaaga tcgagcccga ttgaggtcag 2800801 cttaagtgaa agctctgaat tcaattgatg ttcggcaatg gcttgaatgg ctttcttgca 2800861 ttcctctgcg acttggtttg cttctttttc cgaagctgca tactcgccta aataatcaat 2800921 tgttgcacac aaaccggatc tgtttagcct tttgacggtc ttaaccgccg attcaatcgt 2800981 atcccctgcg acaaaccttc gtgctccaag ccgcgttccg tatgcttttg cgaacttggt 2801041 aagtgtttta ttttgagata agaataaaaa cacatgtctc aacatccgac tccctcccgc 2801101 cgtcatcttc aaaacacctg tatataactc ccagtctgaa ggaaactata aaatgaacag 2801161 aaaccaaagg aggatcacaa tggataatca gcagcaatct caaatgccgc cttccgttat 2801221 ttcgacaaag gatcatttgt atctcaatga catgctgaac tggaatttgc tcgcgatgaa 2801281 aaaagcgcat ttcatggcgc agcagtgcca ggatcaaacg ttaaagcaag aactcgaccg 2801341 cgtcggacac atgcatcatg atcactatca aagaatatta aagcacctgc agccaggcca 2801401 gcagcagtcc ggctacatcc aataaggagg cgccagaatg aatcagcaaa atcaaaaaat 2801461 cagcaacccg cagacacctg taccgacaac atcggaaatg aatgacagag atttcgtcaa 2801521 cgaattgctg acaaccgaaa aatacatgac aacagcttat tgcactgcct tgcacgaatt 2801581 cagccacgag tctctttatc aggatattca atccattttt gatgagtcac aaaaagcgca 2801641 aagaaaacta tatgatctca tgttccaata tggatggtat tctgttgaag cggaggattc 2801701 acaaaagctg cagcagtcct atcaaaaatt ccagcagacc attcagcagc agtctcctta 2801761 tcagcaataa caacattagt aaaaaggata cgatgttctt tcgggcatct atcctttttt 2801821 tgtgtaaaat cagttgactt ttcatttacg cttatttata tttaataagc attaactatt 2801881 ttgtcattaa aatatatata cagtgtatgt aacagagggg aaatgaatat gaagagtgcg 2801941 gatcagttaa tgtccgatat tcaattatcg cttcaggcgc tctttcaaaa gatacagcct 2802001 gaaatgctgg aaagcatgga gaaacaaggt gtcaccccag cgcagctgtt tgtgctggcc 2802061 agcctaaaga aacacggcag cctcaaagtt tctgaaattg ccgagcgtat ggaggtgaag 2802121 ccaagcgcgg tgacgctgat ggcagatcgc cttgaacaaa aaaatcttat cgccagaaca 2802181 cacaacacaa aagacaggcg agtgattgat ctcagtctta ctgacgaagg agacataaag 2802241 ttcgaggagg ttttggcggg cagaaaagcc ataatggcgc gctatctttc ctttttgacg 2802301 gaggaggaaa tgctgcaggc ggcgcatatt acagcaaaac tcgcacaagc agcagaaacg 2802361 gatgaaaagc aaaacatgaa aagaggaaac ggatgaaaat gagtaaagaa ggcaaacaat 2802421 caaaacgaac gttattaata acaggcttaa ttattgccat gtttttttca gcccttgacg 2802481 gtaccattgt cggaacggcc atgccgaaaa ttgtcggtga tctgggcggt ttgagcatga 2802541 tgacctggct gacaactgca tatttgttaa catcaacaac cattgttcca attgccggta 2802601 aactggctga tttattggga cgccgcattg tctatgtatc aggtttgatt atttttatgg 2802661 ccgcttctgc tttgtgcgga atggccaaca acatgacgga attgattatc ttccgtggac 2802721 tgcagggcat cggcggaggc atcatgatgc cgatggcgat gattgtcatc ggtgacttgt 2802781 tcacaggaaa acagcgtgct aaattccaag gtgtctttgg cgcaatttac gggctggctt 2802841 cagtgattgg gccgcaaatc ggcggctgga ttgtagactc gttaaactgg aaatgggttt 2802901 tctatattaa cctgccagtc ggaattattg cggttatttt tattgccagg ggattacagg 2802961 gacgccagca gactggtccg atcaacttcg atatcgctgg tattttcaca atgattgtcg 2803021 gtgtggtcag cctcctgctc gccttaagct ttggcggaaa agattatgca tgggattcat 2803081 ggcagattct tgggttgttc gctctcgcac tgatcggcat tgtcagcttt atcatcgtag 2803141 aatcaaaagc aaaagagcca atcctgccaa tgtatttatt taaaaacaga acatttacat 2803201 ttctaaactt gatcggcttc tttatgagta tcggtatgtt tggcgccatt acgtttgttc 2803261 ctttctttat gcagggaatt gtcggtgtaa gtgcgtctga atcgggtaca attatgacac 2803321 cgatgatgat ttctatgatt atcacaagta tcatcggcgg acagcttgtt tataaaattg 2803381 ggattaaacc gcaaatcatt acaggcatgc tggttatggc cggcggattc ctgctgttaa 2803441 cgacattgga tctcgacacg agcaagcttg tcgctacatc ttttatggcg attattggtc 2803501 tgggaatggg tcttgttatg ccgattctga cattggcttt acaggaaagc ttttcgaagg 2803561 aggagcttgg agttgtcact tcatccagcc aattcttccg ttctatcggc ggaacattcg 2803621 gcattaccat gctgggagcc gtaatgaatg cgagatcagg aaatctatta acagataaat 2803681 tggttccata tttagactct cttccggcac aggcaagctc gtttgccgcc cagctaaagg 2803741 gtatgattga tacaaatccg caagggctgc tgcaatcact gttcagtccg gacgcggtca 2803801 aacaaatccc tgcggctttc tcatcccata ttgtgccgat tttaaaaaca tcgttgatgg 2803861 attcgctcca cagcgtgttt tatacgggcc tgatctttat cgcagtcgga gccgtattca 2803921 ccttgttctt aaaacctatc aagctatcaa ataagaaagc ggaagaccaa caagaaaaag 2803981 agaaggcggc aaaagccgtt gaatcacctt cccattaata gagcaccccg cgggtatcaa 2804041 tccgcggggt tttttattca atcatctggg ctcttccatt tccgaaagac caatcctcat 2804101 cctgatttcc ggccagcatg ataaacacat cttcttttct tacaccaagc tcggaatgaa 2804161 tccggctcgc gattgagcgg taaagtgctt ttttctgttc agttgttctt gactgtttca 2804221 gtgtaaaatg aatgtatatc agttcatcag tacgctcgac ttggagataa aatggatcat 2804281 aaaaaaattc gcttttttca tattgtctga tgacttggaa atagtcatct tccggcacat 2804341 tgatttcttc aatcatcgat tggtggatag tcctgctcag tttttgaagc cacacttcgc 2804401 ttcttcccga ccgtaaatga atctgtacaa atggcatctc cccgcatccc tttctttaca 2804461 gcgtctgtcc gctgtcaatt gtgataattt ggcctgtgag tgattcctgt tcaattagtg 2804521 aacaaatcaa tttggcaaca tcatctggtt cagcaataca ctgcagcagc aaagagccga 2804581 tcatgctttt cattttttct tcccgtccgg cccaccatct cgttgccaca gctcctggtg 2804641 ctacaccgct cactctgatt tcaggcgcta aggcgtgggc caatgatttc gttaaaccgt 2804701 gcaccgctga ttttgatact gcgtaaggca ttgatgagcc ggcaccagtt atccctgcga 2804761 tgctgccgac gtttacgatc gccccgtcct tgcttttctt catgaacgga accactgccc 2804821 gcgcgcagaa aaacatccct ttcacattga cggcatacag ctcatcctag acgtcttctg 2804881 tcgcagcctc aagatcatcc attggaatat gccgtgtaat gctggcattg ttgactaaaa 2804941 tatcaaccgt gccgtgtgtg ttcacgattg cttgaatcat atcctgcacg tcgctgtttt 2805001 tggatacatc tgcttggatg gcgaaggctt gcccgccagc tttttgaatc atttccactg 2805061 tttcctccgc ttctgattgc gagcgtgaat aattcaccgc cacaatcgcc ccacgctttg 2805121 ccaattccat actggctgct tttccgattc ctgtgccgcc ccccgttacg agagctattt 2805181 tgttcaagac attcattgcc gccactcctt gctgttgact aaagtatatt tctgattcca 2805241 ttgtaatcca gctttgatgt tacgtataat gattgttaaa gatactagat atcactcaga 2805301 ttgatagtaa acgaacggag gagttcaaaa tggaaagcgg agatttacgt gtgtttcaaa 2805361 tggtagctcg tgaagggacc attacgaaag cagccctgca gcttggctat gtacaatcga 2805421 atgtcacggc cagaattcaa caattggaag ctgagctggg taccacactg tttttgcgcc 2805481 ataatcgggg catgacactt tctgcaagcg gaaaattgct gctggactac gcaaataaaa 2805541 ttataggcct tcttgatgaa gcgtctaaag cgctctcatc ctccgcagaa ccaagcgggc 2805601 cgcttatgat cggctgcact cagacaaccg ccgcggtaag gcttccaaag cttctggcat 2805661 cttattatga agaacatcca aacgtccagc tgtctttaac aacaggacat acgcaatttc 2805721 tccttgataa agttcttcgt tatgaattgg atggcgcgtt tatcggatgc gaatgccatc 2805781 atcctgagct cgaatcctat cctgcgtttg aggaagaacc agtagttgtt tcggctgcct 2805841 ccgtgcccga tgttgaggaa gccatcacaa agccgattct cgtttacagc acaggctgtt 2805901 cgtatcgaga aacacttgaa aaatggctgc gttccgtcgg tgtcacacag ccggtcatta 2805961 tggaatttgg gacgcttgaa gcaattatcg gcggggttac agcaggtctt ggcatctcgt 2806021 tgctgccaag aacggttgtg cagaaacatg aagcagaagg atcaattcga ttgtacccgc 2806081 tgcctgaagc tctcagccag atgaaaacag agtttattgt tcgaaaagat tcgtttatca 2806141 gcagcgcgct gagaaccttt atggattcct ttacgccagt taaaacggct gaatcacaaa 2806201 aaagcagtct gctataatga acagactgct ttttggctat tgtttgtttc gatgcgcttc 2806261 atttaattcc ttaatatgct gaatgatctc tttaatgccc tgcttcgcgt cggggtatgt 2806321 cgcattccaa tgcttagcga gcggaggcat gcttttggct atatgggtgt acaaaatcca 2806381 ttgcttcact tcttctttta gctcatcgtt tgtttcacca agcagaagct cagtatactt 2806441 ctccagcaat ccatcaagct gctcctgaag tttttgttcc attttccatc ttcctttcga 2806501 aaaaacagca aggagctttc tcaattgaaa gctccttcgc tgcgttattt atccatgtga 2806561 tgtgaaagcc gcttcctgga caatgcatct gcccctgcca tgaggaatgc aaagaggcgt 2806621 tccgaagagc gggtcctgtg taacctgaca gttcatagaa aacacatttt gcacaagatc 2806681 acaagtgatg acctcttccg gacggccttc tgcataaatc cgtttatctt ttatggccac 2806741 aagatgatgc gcatagcggc acgccaagtt taagtcatgg agaaccataa caatcgtccg 2806801 gtcttccttt tcattcagct caaacagcaa atcaagaatt tcaatttgat gcgtcatgtc 2806861 taaatacgtc gtcggctcgt caagaaggat gatatccgtt tcctgggcaa gcgtcatcgc 2806921 gatccaagcc cgctggcgct gtccgcctga caaagaatca acggcacggt cagccatgtc 2806981 ctcaagcttt gttgctttaa gcgctctttc aactgcttcc tcatcctctt ttgaccactg 2807041 cttcagccag ttttggtaag gatatcttcc ttgcttcacc agctgatgca ccgtcagccc 2807101 ctctggagcc gaaggacctt ggggcaggat tgcgagctct tttgcgactt ccttcgtcgg 2807161 aagcttggca atcgctcttc cttccagcag cactgaaccg cctctcggct tcatcaggcg 2807221 cgctaatgaa cgtaaaagtg tcgattttcc gcagccattg ctgccaataa atacggtaat 2807281 ttcacctttg ggaattgtta aattcaactc atcaataata acggcatccc cgtatcctaa 2807341 gctcagcgtt tctgtagaaa ttgcactcat acccataacc gctccttttt gctggctttt 2807401 tagcagcact atgtattgca cgttttctat atacatgctt ttaagtcaat tgtcatcaat 2807461 gcaaatgatt ccgatattca gccatttgat atggtcatat atccctcatt gtagcagaaa 2807521 acactgactt tgaaaatcat tttcaattag ttttatggac ataattgacg tttatgggtt 2807581 ttttatcaca agattacttc ttgatttctc tgatggagcc gtccttcagc ttcaatttta 2807641 aatcgatatg atcataatga ctgtccagat taaatgctgc cagcacactg tgtatcactt 2807701 ctgtttcagc catttggtct gtcacggaaa gctcgctcaa aatcattttc atctcatcta 2807761 acgcttcttc tccttcctga ttgacaccgg agagcttatc ctgtatttcc gctttttcct 2807821 gagtcccgtt ctttgtatag attccttcat aacggttatg ctcaccatcc ccgtagctca 2807881 cacgaagcga aaaattactg tagggaacgg acttcagctg ggtgacggct gtattttctc 2807941 cttctgcctg atgctggtct tcattgaaac ggcagcccgc aatcagaacc actgcgagac 2808001 atacagcccc ggctgctctg atcaaatgca tatgtttccc ccctgtagga ttccatttat 2808061 tttaggtata tccagagaat gaaatcctca ttcagagaag aattgaaaaa gccggggcat 2808121 ttaacgccac ggctttttct ttaagattcg gtcatttgta aaaaggtttc ggcgtcacgc 2808181 acagccagct tgatggcatt ctcccagaaa tcgcgctttg tgatgtcagc gcccaaatgc 2808241 ttcatcgcca aatcctccac tgtcatagaa gccgtatcgc gcaatagcgc catatacttc 2808301 tcttcgaatg tgtctttttc ttcaagcgcc aacgcgtaaa taccaagaga aaacaggtag 2808361 ccgaatgtat aagggaaatt gtaaaacggc accctcgtga tgtgaaaatg aagctttgat 2808421 gcccaaaaaa gcggatgata ttcttctaac gcattgcagt atgcctctct ttgcgcctct 2808481 tccatcagct cattcaagcg gctggccggt accactcccc gctttcgttc ctcgtagaat 2808541 ctcgtttcaa atagaaatct tgcgtgaatg ttcatgaaga acgcaacgct tctttgcact 2808601 ttatcctcca gaagaacaag cttttcttcc ctcgtctcgg cctgctggac agtcgcgtcc 2808661 gccactatca tctctgcaaa cgttgaagct gtttctgcaa cgttcatggc gtaggaacgg 2808721 tttaacggcc tgacgttgag cattgcttcc tgatggaacg cgtgcccgag ttcatgcgca 2808781 agggtagaga catttgaggc gcttcccgaa aatgtcatga aaatccggga ttccccgctg 2808841 tccggaaaac tggtgcaaaa gccgccgact ctttttccgc tcctgtcttc cgcctcaatc 2808901 cagccgtccc gaaacgcttt ttcagtgaat gaggacagct ttttgccaaa cgttgaaaac 2808961 tggctggtaa tgatatttgc ggcttcatca tacgaataga cctttccgtc agaaccgatc 2809021 ggtgcctcga catcgtacca gctgagtttt tcaaggccga gcatggatgc tttccggttc 2809081 aaaaactgaa cgaacggctt cttgttttca gtgatgacct gccacatcgt atcaagtgtt 2809141 tcttttttca tcctgttaat ttgcagcggt tccttcagga cattctccca gccgcgcgct 2809201 ttataggttt caagccggaa tcccgccaaa tgattcagcg tgctgctgaa aatatcttgc 2809261 ttgctctccc aagcttggcg gaaacgttca tatactgttt ttctgacagt acggtcttga 2809321 tgatccatca tattctccgc ctgaccgaca gacaattgct tgttttcacc gttttcctca 2809381 tacgggatcg tcattttccc gacaaccata ttgtataagt cactccaagc gtgatatccg 2809441 tccaccgcaa ggtttccgat cagtttttcc ttaccggggc taagcttttc ggcaaccctc 2809501 tgtcttcttt catttaatat gtaagaaaca tcgcgcaatc ccggttttgt taacaattca 2809561 ttccacacgt cttgattaat gtccacaagt ttatgatcta atgtaacgag cgacgattga 2809621 aaatctgcgg aaagccgatt catgaggcct gatgctctat agccttttga tcattgatat 2809681 tctgggcctg gaggcaagca acaaaagcgc cggcctgctg aagcttgacg gatgtctgtt 2809741 cgaataaatc aagcaacgcg gtcagccctt cagcctcttc aggcgattca ggcacctgaa 2809801 acgcatcagt cctgtcttga aatgcacgca gactttgtga cagcttctca atataacctt 2809861 tgaattcttc cgattggctc ccgcccttaa aaaatgaatc aagatcccat ctttggccta 2809921 ccccttgcag cgccatatca caaaacccct ttccttcttt cgttctatta tagaacaatt 2809981 ctgaattatt gtataaaaat ttctattaca ggcgtcattt cgtgttcagg atagtacaat 2810041 agctgtagca gtttaatagg agggttagga tgaataaaaa aatagccatc gtgacaggag 2810101 cgtccagcgg cttcggtctg ctggcagctg taaagcttgc ccgatcattt ttcgtgatag 2810161 ccacatcaag acagcctgaa aaagcggaac agcttcgaga attggctgca gcacacaatg 2810221 tgtctgattc tattcacatt acagctctcg atgtcaccga tgaacaatct atagtctcat 2810281 tcggaaaagc tgttagtgct tacgccccga tcgatttact cgttaacaac gccggaacgg 2810341 cttatggagg atttatcgag gatgtgccga tggaacattt cagacaacaa tttgaaacga 2810401 atgtcttcgg tgtgatccat gtgacaaaaa ccgtgctgcc ttacataaga aagcatggcg 2810461 gcgcaaagat tataaacgtg agcagcatca gcggactgac aggattccca gcgctgtcgc 2810521 catatgtttc ttccaagcat gcattggaag gtttttctga aagcctgcgt atcgagctgc 2810581 ttccgttcgg tatcgaaacc gctttgatcg agccgggctc atacaagaca tcgatctggt 2810641 caacgtcatt atcaaatttt atgtcggtgc ctgctgacga ttcagcctat catcaatact 2810701 ataaaaagat cctttcctat gttcaaaaaa acggagaaga aagcggagat ccccaagagg 2810761 ttgccgacct catttatcaa ttggcaacaa aacagcacat aaagaatttg cgatacccga 2810821 tcggaaaggg catcaagctc accctgctgt tccgatcgct ttttccttgg tctgcgtggg 2810881 agtctatcct gaagaaaaag ctattcagct gatctaaatt ataattatta taatttagta 2810941 ttgattttta tttagtatat gatataatta agtcaacaga tcacaaggag gacgttatct 2811001 tatgaaaact gaaaacgcaa aaacaaatca aacattagtt gagaattcac tgaacacaca 2811061 attatcaaac tggtttcttt tatactctaa gctccaccgt ttccattggt atgtgaaagg 2811121 gcctcatttc tttacattgc acgagaaatt tgaagaactt tatgaccatg cggctgaaac 2811181 agtggatacc atcgctgagc gcctgctggc gattggcgga cagcctgttg ccacagtgaa 2811241 agaatacact gagcatgcat ctatcacaga cggcggaaac gaaacatcag catcagaaat 2811301 ggtacaagca ttggtaaacg actacaaaca aatcagcagc gaatctaaat tcgtgatcgg 2811361 cctggctgaa gaaaatcaag acaatgcgac agcggacttg tttgtcggat taattgaaga 2811421 agttgaaaaa caagtgtgga tgctttcctc ttatttaggg taacaaaaaa gctgaacctt 2811481 aatcgggttc agctttttgt tttttcttag cttgaactgc tttctgtctg cttggtcagt 2811541 gttgcgttca acgttttcgt ttttcccttt cgcagcactt ggattgttgt tttatctccg 2811601 acttttaagt ctttgtaaag gatctgacgg atatccgcac tgctttccac gtctttaccg 2811661 tttagtttga caatgacatc ctcagattta atacctgctt tttctgccgg cgaatttgct 2811721 tgaacttctt ttacataaac acctttgccc aattgatctc caaacaggcc gagcgtattt 2811781 tcctgatagg tttcaggaac ttgtgacatg tcaatcatct gcacgcctaa aaacggacgg 2811841 tccaccttcc cgttttgcag cagctggtca acaatcggct cgacatcatt gcttgggatc 2811901 gcaaatccaa gtgattccac gccgctttcg ctcaccttca agctgttgat gccgatgacc 2811961 tggccgcttg cattgattaa tgggcctccg ctgttccccg gattgatcgc tgcatcggtt 2812021 tgcagcacgt tcatttccac cgtcccctgt gttgtatcca catcaattgt ccggttcagt 2812081 ccgctaatga taccttgtgt cactgtaccg gaaaactgct gtccgagcgg gttaccgata 2812141 gcgattacct tttcgccagt gcgcagctgt gaagagtcac caaagctcgc cacttttttt 2812201 acattcttgc cgctgatttc caaaactgcc aaatcagtaa tggtatcgct gccgacaagc 2812261 ttggcagttt ccgtttctcc gttgtatagc gtaacagtca gcttgttcgc gccttcaacg 2812321 acatggttgt ttgtaatgat atacgcttta tcgctgtctt ttttgaaaat aacacctgac 2812381 ccggttccgc tttcactttc tgagctggag cctcctcccg tgccgaatgt gttattttga 2812441 gaggtttgga tatttgagat tccgacaatc gtaggctcta aatcctctac catatcagcg 2812501 atgtttgatg cgttcgttat cggcgccgtt gtaaaattat cagactgcac ctgtttattt 2812561 gcggaagcgg tttcggtcgc ctgattttgg tctgacggca gataaggcgc gatgccaagc 2812621 atgaggcccc cgccgataat accgcctaaa atcgggctca gccatgcggc tctccgtttc 2812681 ttttcttttt tcacagccgt ttcttgcttt tccatttcta aagcagaagc cgtttcctgc 2812741 cgtcccgctt catacgacac aggcgcgtca agcaattctt gttcagaatg tccaatcagc 2812801 ttctggtttt ctgtattctg ctgttctgta tgtgaaggtt cagtttgatg ttgatcgttt 2812861 tggccatcac gtcgataatc catgttctta cactccttta acggttattc atttatcgtt 2812921 acatattcat cgcatgtaca agttcaattg tcccaataat gaggagaaaa gcaaagcacc 2812981 aaaatagaat atgtttgatc atcctacatc ttcctcgctc tttttctctt cctttcttcc 2813041 cttaaccata tcataaacaa acattgtggg ataaaaatga aaagaatatg tgaaattatg 2813101 aaaattgcct gccgtatgtt aaaactagtt tataatgacg ttgaaaggat gtgaagagcc 2813161 ttgtcataca ccatttatct agttgaagat gaggataacc tgaatgaact gctgacgaag 2813221 tatttagaga atgagggctg gaacattaca tcttttacga aaggtgaaga cgccagaaag 2813281 aaaatgacac cgtctcccca cctatggatt ctcgatatca tgctgccgga taccgacggc 2813341 tatacattaa taaaagaaat caaggcgaaa gatcctgacg tgccggtcat ttttatttcc 2813401 gcccgagatg cggatattga cagagtgctt ggcttagagc ttggcagcaa tgactacatt 2813461 tcaaagccgt ttttgccgcg ggagctgatt atccgtgtgc aaaagctgct gcagctcgta 2813521 tataaggaag ctcctcctgt ccaaaaaaat gaaattgccg tctcctcgta tcgggtcgct 2813581 gaagacgccc gcgaggtcta tgacgaaaac gggaatatca tcaatttgac gtcaaaggaa 2813641 tttgatctgc tgctattatt tatccatcat aaagggcatc catactctcg tgaggatatc 2813701 ctcctaaaag tgtggggaca tgactacttc ggaacagacc gggtcgttga tgatctcgtc 2813761 cggagactgc gcagaaagat gcctgaattg aaggtggaga cgatttacgg tttcggctac 2813821 aggatgatgt catcatgaaa aacaagccgc tcgcgtttca gatatgggtt gtcatatccg 2813881 gcatcctgtt agcgatatcg attttactgc ttgtgttatt ttcaaacacg ctgcgagatt 2813941 ttttcactaa tgaaacgtat acgacgattg aaaatgagca gcatgttctg acagagtacc 2814001 gcctgccagg ttcgattgaa aggcgctatt acagcgagga agcgacggcg ccgacaactg 2814061 tccgctccgt acagcacgtg ctccttcctg aaaatgaaga ggcttcttca gacaaggatt 2814121 taagcattct gtcatcttca tttatccaca aggtgtacaa gctggctgat aagcaggaag 2814181 ctaaaaagaa acgttacagc gccgacgtca atggagagaa agtgtttttt gtcattaaaa 2814241 agggactttc cgtcaatgga caatcagcga tgatgctctc ttacgcgctt gattcttatc 2814301 gggacgattt ggcctatacc ttgttcaaac agcttctgtt tattatagct gtcgtcattt 2814361 tattaagctg gattccggct atttggcttg caaagtattt atcaaggcct cttgtatcat 2814421 ttgaaaaaca cgtcaaacgg atttctgaac aggattggga tgacccagta aaagtggacc 2814481 ggaaagatga aatcggcaaa ttgggccata ccatcgaaga gatgcgccaa aagcttgtgc 2814541 aaaaggatga aacagaaaga actctattgc aaaatatctc tcatgattta aaaacgccgg 2814601 tcatggtcat cagaggctat acacaatcaa ttaaagacgg gatttttcct aaaggagacc 2814661 ttgaaaacac tgtagatgtt attgaatgcg aagctcttaa gctggagaaa aaaataaagg 2814721 atttattata tttaacgaag ctggattatt tagcgaagca aaaagtgcag cacgacatgt 2814781 tcagtattgt ggaagtgaca gaagaagtca tcgaacgatt gaagtgggcg cggaaagaac 2814841 tatcgtggga aattgatgta gaagaggata ttttgatgcc gggcgatccg gagcaatgga 2814901 acaaactcct cgaaaacatt ttggaaaatc aaatccgcta tgctgagaca aaaatagaaa 2814961 tcagcatgaa acaagatgat cgaaatatcg tgatcaccat taaaaatgac ggtccgcata 2815021 ttgaagatga gatgctctcc agcctctatg agccttttaa taaagggaag aaaggcgaat 2815081 tcggcattgg tctaagcatc gtaaaacgaa ttttaactct tcataaggca tctatctcaa 2815141 ttgaaaatga caaaacgggt gtaacatacc gcatagcagt gccaaaatag actgtagatg 2815201 ttttgcagtc tattttttta tgtgaaagaa tagccgttaa aatctctgta atttgttttg 2815261 agcggctgtt tgcattgatg aacccatttt ttctctgaca aggtctgctt cggatatttg 2815321 actttctcca ctttgattcc tctgtttcgc aagcggctga tcatttcgtc caattctctc 2815381 attctagatt caccctttcg cttgagcttt gaccattcgg tcatctcaat ttataatata 2815441 aataatacat gataaaaaaa caagttacaa taaggttaat tttataacag acggtgtgac 2815501 tatatggtca tatcctagca ggcctccggg ctccgaaagg gtggaaccat tgaaggaaaa 2815561 agaaaaactg attattgaaa cagccttaaa actatttgcc caaaaaggat acaactcaac 2815621 atcagtccag gaaatcgcaa aagaatgcaa aatatctaaa ggcgcttttt atatttattt 2815681 tccttcgaaa gaagcgcttc ttctctctat gctgaactac tattatgata aaacgtttac 2815741 ccgaatttta aatattaaaa cgaagggcga cagccccaga acggcttacc gtaaacagct 2815801 gaccgtcctc tatgaaaaca ttcttgaaca caaagatttt atcagcatgc agttgaagga 2815861 gggttctctg ccttacacag aagaagtgga gcaatgcgca aaaaaaatcc gccagtcctc 2815921 acttcaattt catatcgaca gcctgctgaa catctatgga aaaaaagcgg aaccgtacac 2815981 tgctgagctt tgttttttaa tagagggcat cagccagatt tacctggaat gcatgatttt 2816041 gctcgggtac actgtgaagc cgtctcaatt agctgatatc attatgaatc gaattgatga 2816101 tatggtaaaa ggcatgtctg aacgaaacga taagcctttc atcacattgg aagaggcgag 2816161 ctctttattc ggacctctta cgcacggacg gcctgacccg ctgactgaat caattgtgaa 2816221 aagcctacgt gacaaaatta acagcttaaa cacaaactcc tctcttgaat tatcggagag 2816281 cttggacata cttgaagcag aaatgaagaa aaaaacaccg aagctggcga tcataaaagg 2816341 aatgattcat aatctgacgg agtctgaagc tctcgccaaa gatgcggaac agcttaaata 2816401 tttattaaaa cagcaacata tttagaagaa cggctgctta aaaagcagcc gttcttccta 2816461 ttacgccttt ggttttacca tgtcttccgg cttaaccatt tcgttaaatt gctcctctgt 2816521 cagcaattca agcttcaaag ctgcttcttt gagcgtcaat ccctctttat gggcaagctt 2816581 ggcgattttc gccgcgtttt cataaccgat atgcgggttc agcgccgtaa caagcattaa 2816641 tgaatttgac aggttttcct gaatggtttc tttattaggc tcaataccga cagcacattt 2816701 atcatggaat gaattcatgc cgtcactgag cagctgcaca gattgcagga agttgtaaat 2816761 aataacaggc ttaaacacgt tcagttcaaa gttcccctga ctcgccgcaa agccgattgt 2816821 cgcatcgttc cccatgattt gcgctgcgat cattgttaac gcttcgcttt gtgtcggatt 2816881 gactttacca ggcataatag agcttcccgg ctcattttca ggaatgacga tctccccgat 2816941 gccgcagcgg ggtccgcttg cgagccatct gacatcgttc gcgattttca ttaagtcagc 2817001 cgcaagcgct tttaatgcgc catgcgcata agtgatttcg tcatggcttg tcagcgcgtg 2817061 gaatttattc ggcgagctgc tgaacgtttg gccggtcagc ttagtgatct cttctgagac 2817121 aagctctcca aactctgggt gggcgttgat acccgttccg acagccgttc caccaattgc 2817181 aagcgcacgc attttatctg tcgcttccaa aatcatttcc ttcgaacggt ccagcatgtg 2817241 aacccatccg ctgatttcct gtccgagggt cagtggcgta gcatcctgaa gatgcgtgcg 2817301 tccgattttg acaatatcat tgtatgcttt tgctttttca tccagtgtat tgcgaagctg 2817361 atcaagcgcc ggcacaagct gctcgtaaac agccaaaaca gcggcaacat gcatcgcagt 2817421 cgggaatgtg tcgtttgagc tttggcttcg gttcacgtca tcatttggat gaatcgtttg 2817481 atcagagttc ttctctttta ataaagcagt cgcacggttg gctaccactt cgttcatgtt 2817541 catattgctt tgtgtgccgc ttccggtctg ccatacgaca agcgggaagt tgtcatcgta 2817601 cttgcctttg agcacatcat cacaaaccgc tgcaatcgct tctgcttttt cagcgtccag 2817661 attgccgagg cgtttattag ctagagcagt gcttcgtttt aaaattgcaa acgccttcac 2817721 aacacgcatc ggcatttttt cagaaccgat cttaaagttc tccttgcttc gctgtgtttg 2817781 ggcgccccaa aatttatcag caggaacttt tacttctccc atggtgtctc gttcaattct 2817841 gtattccatt tatgtatccc tccataacgg ttgcttcaat agatcataat tcgccaatga 2817901 cacaaaaaat cctttttatt tttcgatctt ggcagatttt aattttaatt caagatatac 2817961 gcgggaatcc tttgaatatt tgtattttgg atttgtcctg ccgtactcct ttgatgtata 2818021 agagacatca taatgctgtt caaatgatct aatgagctgt tcaatttctt cttgttttcc 2818081 agctagcctt acctgtgcca cttcgtatcc tccgctttca taaaaaaact tactccatga 2818141 aatactctaa cacagtatat cattttttta acaggaaaag ataacctcta ctaaggtttt 2818201 ggataagagg tgacctcatt ggaacaaaca gagtttaagg aatatataca cgataattta 2818261 gcattggtgc tgccaaaatt aaaagaaaac gatgatctgg tgaaaaacaa aaaaatgctt 2818321 gcgaacggac tggtttttta ctatctctat ttcagtgaaa tgactgatga gaataaggtg 2818381 tcagaagcca ttaaaacttt gattaaagat gaggagacct taacgcttga ccaggtcaaa 2818441 aaacgccttg accagcttga cgcaagacct gttgaaactg caaaaaaaac gattgaatcg 2818501 attctcaacg gcaattgtgc tgtgtttatc aacggattgg ataaagccta tattctgacc 2818561 acaggaaaga aaaaaacaag aagcctgaca gagccgacaa ctgaaaaagt ggttcgcggc 2818621 ccaaaagtag cgtttgtaga ggatattgat acaaatctcg ctctgatcag acaaagaacc 2818681 tctcatccga aattgatcac caaaaaaatc atgatcggcg aaaacaagct gaagcctgca 2818741 gccattatgt acattgaagg caaagcaaaa aagtccgtca taaaagaagt gaaggcgcgg 2818801 cttaaaaata tccagctgga agatatccag gacagcggaa cgctcgagga gctcattgaa 2818861 gataataaat attcaccatt tccgcagata caaaatacgg aaagacctga caaagtatct 2818921 tcagccctgt ttaacggccg tgtggcaatt ttggtcgaca gttcaccatt tgtgctgctg 2818981 gtgccggttt ctctcggcat cctgatgcaa tccccggatg actactatga acgctggatt 2819041 tcagcatctc ttatccggtc gctgcgcttt gcttctatct ttatcacctt gtttttgtca 2819101 tcgatttata taacacttgt ttccttccat caggggctgc tgccgaccgc actcgccgtc 2819161 acgatttcgg cgaacaggga aaacgtgccg ttccctccga tatttgaagc cctgctgatg 2819221 gaagtcacca tcgagctgct aagggaagcc ggactgcgac tccccaatcc gctcggacag 2819281 acgatcggcc tcgttggggg cgtagtcatc ggacaggctg ctgtagaagc gaatctcgtc 2819341 agttcgattt tggtcattgt cgtcagtgtc attgccctgg catcctttac cgttcctcaa 2819401 tacggaatgg gtctgtcttt ccgggtgctg cgttttattt cgatgttttc cgccgctatt 2819461 ttagggctat acggcattat tttatttatg cttgtcgttt atacgcactt aacgagacaa 2819521 acgagctttg ggtctccgta tttttcgcca aacggattct ttagcctgaa aaatacggat 2819581 gactccatta tccgtctccc aattaaaaac aaaccaaaag aggtgaataa tccaaatgag 2819641 ccaaaaacag actccactga aacttaatac ctttcaaggt atttctattg ttgcaaatac 2819701 aatgcttggg gccggacttt taacattgcc gcgagcgctg accactaagg ctaatacgcc 2819761 tgacggctgg atcacgctga tattagaagg tttcattttt attttcttca tttatttaaa 2819821 cacgctcatt cagaaaaaac atcaataccc ttcactcttt gaatatttga aggaagggct 2819881 tgggaaatgg atcggcagca tcatcggcct tttgatctgc ggctatttcc tcggcgtagc 2819941 cagcttcgag acacgggcaa tggctgaaat ggtgaagttt ttcctgctgg agagaacccc 2820001 aattcaagtc attattttaa cgtttatttg ctgcggcatt tatttaatgg ttgggggctt 2820061 aagcgatgtg tcgcggctgt ttccctttta tttaacggta accattatta ttttgctgat 2820121 tgtgttcggg atcagtttta aaatttttga tatcaataat ttgcgtcctg ttttaggcga 2820181 aggccttgga cccattgcaa actcccttac cgtcgtttcc atctcttttt taggaatgga 2820241 agtgatgctg tttcttcctg aacatatgaa gaaaaagaaa tacacgttca gatatgcgtc 2820301 tctaggattt ctgattccga ttatcttata tatccttacg tatattatcg ttgtcggagc 2820361 tttgaccgct cccgaggtga aaacgctgat ttggccgact atttctctct ttcagtcctt 2820421 tgagcttaaa ggcatattta ttgaacggtt tgaatccttt ttactggtgg tctggattat 2820481 ccagtttttc accacatttg tcatttacgg atactttgcc gctaacgggc taaagaagac 2820541 atttggatta tcgactaaaa caagcatggt gattatcggc ataacggtct tttatttttc 2820601 tctctggccg gatgacgcca atcaagtcat gatgtatagc gattatcttg gctatatttt 2820661 tgtctccctg tttctgcttc cgttcattct ctttttcatt gtagctctca agaggaggat 2820721 tacaacaaaa tgaaaatccg gattttatgt atgtttatat gcaccctatt gctgtccgga 2820781 tgctgggaca gtgagaatat cgaggaatta agcttagtga tcggaatagg gctagacaag 2820841 cctgacgatg aaaatttaga gctgacacag caaattctcg tgccgaaaat aatcagcgcc 2820901 aaggagggct cttcatctga tccgacacag ctttctatca caaagggtaa aactgtccat 2820961 caaatgatga gaacctctgc attaaagcat aagcctacgt tttcacagca tttgcgtctc 2821021 attctgcttt ccaaaagcgt gattgcggat caaattggaa tggacgccat tattaaccag 2821081 tttgtcagag acaacggaac aaggaggagt tcctacgtct ttatcaccaa cggccgaact 2821141 aaggatatat ttaacatgaa tgatgaaggc gaacccgcat ccaacgtgat atatgatctg 2821201 acagagaata ataaggtgac gatcagaacg atggagccag ttacattggg ggagatctca 2821261 gaacacttaa cctctgacga ttcattcctc atccctcatg tcggtaagga aaacggcaag 2821321 ctcgcgataa acggagcctc tatcataaaa aataaattat ggcaccggga cctcaccccg 2821381 attgaggttc aaaatatcag cttattttca ggcactgtcg agggaggcgt cattgacttg 2821441 aagcgcgatg gccatctctt ttcttatgaa gtatattcaa gcaatcggaa gatcaagacg 2821501 gcatacaagg acggaaagtt caaattcacc gttacccgca atattgaagg tcgtctatct 2821561 gaggactgga atcccaatga agactcgttt aaggattcat atattaaaag tattgaaaag 2821621 acagtcgaaa aacgagtaca cgaaacagta acgtcattta ttacagagaa gctgcagaaa 2821681 gagatcaaag cggacgtaac cgggctggga aacgaggtca gaattcatta tcctcaaaag 2821741 tggaaaaaga tttcaagaaa atgggatgat gattatttca gcaatgcgga aatagactac 2821801 cgggtcaatg tgattgtcag agacttcgga acgaaaggcg caaacaaata gcagccgcct 2821861 aattcacgag atgatttcgg tgtgcgtaca ccgccgcctg cgtccggtca ctgacatcca 2821921 gctttgataa aatattcgta atatgtgttt tgactgtttt aatcgtaata aacagttcct 2821981 cgcctatttc tttgtttgtc tttccttctg cgatcaggca gagtatttcg agctcccgtt 2822041 ttgtaagcga ttcatgcggg agcgcgtttt cacctgagtg gcgcagcctg gataatactt 2822101 ttcccgccac ttttgactcc agcttcggct ctcccttgct tgcggcgcgg atggcatcgg 2822161 cgatttctgc cgcttttgag gttttcaaca gatagctgag cgcgccagct tcaataaccg 2822221 ggtacacttt gtcatcatca atgaagctag tgagcacaat aattttcggg tcggaaagct 2822281 cccggcaaat ttgctttgta gcttcaatgc catccatgcc ctccatgaca aggtccatta 2822341 aaatgacatc aggcgacagt tccacagcaa gccgaacacc ttcgctgccg tccgatgctt 2822401 cgccgatgac ttcaatatcg ggctgcgcct ccaaaaaagc cgcgagcccc attctgacca 2822461 tttcatgatc atcaatcaat aatactcgaa tcacgttcgt tctctccttt ttcttccgga 2822521 aaaatcggga ccttcacttc gatttgagtg ccttttcctt ctactgaaat cacttcggcg 2822581 acaccgccga tttcacttgc acgttctttc atagaattca agccgtatga ggaggctttc 2822641 acctggtcca ttttaaagcc ttttccatta tcaatcacct tcagacggag ctggctgttc 2822701 tttatgccca gaatcacggt tacttttgac gcttttgaat gtctaaatac gtttgaaagg 2822761 gcctcctgca cgattctgaa caagtggtct tcaacaccct tggatatcgc tgtgtcctgt 2822821 atatcccact caatatcaat cggctgcttt tttcggaact cgtccaaaag ctccgtaagg 2822881 ccctccttca gcccttttcc ttcaagggta acaggccgta aatggagcag cagcgccctc 2822941 atctcatttt gggcttcgcc tgccatatgc tcgaccatcc tgatccgctt gactgttttg 2823001 tcatcagcat ccttgacatg ttccagcacg gctgatgtca tcatcgatat ggcaaagagc 2823061 tgctggctga ccgcatcatg aagatctctg gccaatcgct ggcgttcttc tgagataacc 2823121 gacttcttca tttgagcctg ccattccgca cgttcattgg aaagtttctg gagggatgcg 2823181 acttgaagct ccacgcgctt cgccatttcg ttcagctgat cagcagccag gccgatttca 2823241 tcatcaccga gcggcggtat ccgataagcg aaattgccgt tttcaaaggt taaaatggat 2823301 tcaattaatg tatcaatcct tgtcttcaac cggttgccgt acatataccc tgaggcgaaa 2823361 ccgacggtca cgctgatcag aagcaaaatc aggataaacg gaattccgaa ccagcttgat 2823421 gacagcaaaa caagcggatc gagccgatag taaaacatca taaaggaaat caggcaaaca 2823481 aaaaggagca ggctgattcc cgttgtcatg cggatggcgc gccattggag gctggcaagc 2823541 attttttttc tcatacgtac ttcacatcca catcaccgat aaataaggaa acggacactt 2823601 ttacccggcg ctttgactcg ctaaaatcag ttgacgcggc atataccttc gtgcttaatc 2823661 cgcttttctt cgagccgatc agattaatgt ctcctataaa aacagccgag ctgacagcca 2823721 cttcaaggtc cgatggtaca taaatatcaa cgttaccaat gactccgcta atgacgattg 2823781 tactttctcc ctcgggaatc atcgctttag ataaatcgat tttgatatca ccgataaaac 2823841 cagagacatt taaatcgttc aggtcaaacg gctgcttcat catttgcagc tcaccgataa 2823901 aaaagctgcg catgtcggga tgttttacat cttttggcgg ctcatgatgt tcttttttat 2823961 tgagattgac ctgtttctca ttcggttcaa atatcggctt ccctttgata agcctgtagc 2824021 cggcgtaaat cagaaatgcg gcaaacgcat agccgaataa attaaaggtg atgctgaaga 2824081 ggtttttcaa aaatagaaac gcggcaaaga tatacatgac ggagccaagc caatcacggg 2824141 aatatttttt aaggaaatag ccggcaatca gaaaaaagag cggccaaaac agcagatcgc 2824201 ctattccgat aatttgcaaa aacatactga tgccgaataa agcaatgatc aatccgagaa 2824261 gctgtttttt tgtcattcct ggtgtccgcc tcctttcttc tgcctagtgc taccgtatcg 2824321 ctagatcccc gctgtccgtt ttgatgtcga ttggatgccg gccgcttcct tgcgtgcctg 2824381 tgatgtgatg ctgttcttta tgtcctttat cagcaaatga atacggcgaa ctgacgtcac 2824441 cgcttgctga taaagcattg actgcaaagc tgccattttg gggaaggctt acattagcat 2824501 caccgcttgt cagcgtgaca gatacgggac cggttacctt tttcaataca gcattaaaat 2824561 ctcctgaagt cattttcaca tcaagagagc ctgatacatg aaccagattt gcgtcccctg 2824621 aagctaaatc aatgccggct gttttggaga cggtatttga aatggaaaca tcccccgatg 2824681 atgccttcac tttcagatct tgaatgcgga cgtccgtcac gctcgtattt ccgctcgcag 2824741 atactgcgtt cagcccggaa agcgcaagat ggtcattccc ggccacagac acgtcaccgc 2824801 ttgaggttcg tactgccaga tcacctttat aatcatacgg aagcctgacg ataagagttg 2824861 aacggttaaa tccattcaaa aattgaaatt ctttttcctt tacggtcagc tccagttttc 2824921 ttttgttttc agtaacaaat aactttcctg agtctcctga aatgcctgcc gatatgtcac 2824981 ttcgttcttc cgctataatc cggacatcct tgctatccga ctcaatgacc atgctgtcaa 2825041 tgtcccgcgg cgatgcgctg gctgaatcag cttctgtgcc atttatgaaa cctaggcctg 2825101 cagcaaacac atcttttacg acgacggcga aaaaaaccag aataccggca gtgatcaaca 2825161 gtttgccaag catttttttc attcggtttc atccttctca ttcattctat tataaaggaa 2825221 aagcttgcga attgatacgt gcggaaggga aggacttgac cgcaaatcct tccccgttcc 2825281 gcttattcat ttgccgcttt tgtctggtct gatttttgca gtgaaagtgt ccgcattttt 2825341 tcaatctccg cttccacatc gtctgcgaat tctttacgtg taagttctgt gccggcttcc 2825401 gctgactttg aataattcgc gcggatttcc atttcttcaa tacgattttc aatacgtaaa 2825461 aattcacgat acgcgctttc actgtcaatt ttgtcaaatg tcgtattcat atgctcttta 2825521 gctttcgccg catttgcccg cgcaatcagc gcctgttttt tatcctttac gtcctgaagc 2825581 tttgtttcaa gtgcagccag ctgctctttc agatcagcca gctgactgtt tgcctgttca 2825641 taggaagctt tatgctcagc cgccttccct tctaaatact tcatttcagt cagcgccttt 2825701 ttcgccagtt cttcttcacc tgcgtcaaat gcgagctgtg cctgattttt ccgtttgcca 2825761 gccacttcag cggcttcttc atattttttc ttaaattgat aggcaatcgt gtgctgtttc 2825821 acaattgttt gctttgcttt tgcgatgtcg ctttccatat cgcgtacata ttgattcagc 2825881 atcacctttg gattctccat tttatcaagt ccttcatgaa ctgacgcaac aaacatgtct 2825941 ctgattcttt ttaataccat acctgattcc tcctaatata ttgatattat tttttcttca 2826001 aaaattcttc ccattcgtca tcaaagtgag attggtaggc agcagaagcc ggttcaggat 2826061 caaaagatga tacaccgtta tcagctgatc cgtttttcat cagcttccag ccgtaataca 2826121 ccatagcggc cgccaatgcg attccgacga caaacggaag tgagcagatg agcataatgg 2826181 ctccgatacc gcccacgatg attcccgtga tggtttttcc cgcggcaaac cttttgattc 2826241 ctgcgtatgt catcaagctc ccgatggcga gcgggatgat aaagccgaag cttcctcctc 2826301 caaaaaagac ggagatccca aatacaatta ataagaatcc gcctattgtt ttcttgttta 2826361 ttttcatgca gatcctcctt tcgttttcct tgtcttcatc ttatacaagt tggaagatat 2826421 gcaaaacgaa tcagagattg atttttatat aagaccggag tcgtatctcg caccggaccc 2826481 attggcacaa aaaaacgcca tgcacgaggc atggcgtttt aaaacccttt acagatgaac 2826541 acttgcttcc ctttctttaa ttaggtcgga cctttctgct ttggccaatt ttgtaaacag 2826601 caagattccg atacccgcaa taatttcgac aatcccaccg acagcgatca ctttacctga 2826661 gccgaaagca ttagcggcat acccgcaaat gacagctccg gcagggatcg aaatatttga 2826721 gatcatatgt ataacggcgt aaacctgcgg ctgatcctca ctatccacag acgtctggat 2826781 aatcgtgtac tcaggaacat taacagcact gactgcggca ccaaaggtaa aagcagcgaa 2826841 aaagacgagc ggcaaaaagg tattcatccc ggtaataaag aaagcaaatc cttcaataat 2826901 gccggcagtg acgaataaca agccgtacct gtttaccttg actttcgcca gcacaaaccc 2826961 taataaaaac gcgcccgcgg cggtggtggc ctttaaaagc gagtatacga tcggctggcc 2827021 gtttaaatct tccgcaacgt atacggcaga gagcgcttcc catggggcag ccgcgaaatt 2827081 cataaagata cagtaaatgg cgagcggata taaaatctgg tgttttctga cgagcctaaa 2827141 gccgcgtttc agtcttccga tatatgtgcc tctctgtgta acaaccgcag actctgattg 2827201 agattcaacc gcagtgtact taataaaaag aacgagaaaa cctgacacca aatagagcac 2827261 aagtgcgata agcatggtat aagaaggact aataaatgta agaaaagcgc cgcataatgt 2827321 gacagcccca agccggacaa tttgagcgga ggattgcagc acagcgtttg ctttttgaat 2827381 gccctgttca ttgacgattt gaggaatcaa agcgatagag gcgggattgt aggcagctcc 2827441 agtagctgaa tgcacaatca taagcgtcat gacaaaccac agcggagaga agcccgcaaa 2827501 atgacataga gggataatca aaacaatcgc cgcccttgtc agatctgaaa agtacatcca 2827561 aaatttcagc gtggtctgtt tcataaaagg ccccgtcaca ggcgccagaa cggcttccgg 2827621 caaaaacgtg acagcaatca ataaagcagt gccgatcgca cctttgccgt cataaattaa 2827681 aaaccataat attgaattaa atgcgaacat atcgccggat atcttgacta ttcttgagaa 2827741 aaacagataa ttgaaatttc tcttccagat gctatcactt tcaattaaat tcaccatcca 2827801 tcagagcccc ccgttgccta ttttttacat ctatttatta caatatctca tttttccatt 2827861 tttcagtcaa taattcataa ggttcatttt ttgtcgtaaa atgggaaatt gacagagtga 2827921 aaaacaaaaa aagccggcat gtatttgaac acgccggctt tccttttcac tttttatgat 2827981 tcgctgctgt ttcggtcccg aaacacaatg gcacttcttt catattctac atcgccaata 2828041 ccgcttcttg cattcacaac ccgggcggcg gcaaagaaat aatcggacag acgattgaga 2828101 taacgcagca ctgtttcatg aatctcctcc gatttcatca gcgccaccac tcttcgttct 2828161 gcccgccttg taatggtgcg tgcgatatgg agaagcgaag cacactttga tccgcctgga 2828221 agaataaatt tcttcagttc cggcgcttct gctgtatagg catcaatgcg cgtttctaaa 2828281 aaggaaacag attcttccgt tagtttatag tcttttcttt ctgtgacgat tgccagatcg 2828341 cctccgcagt caaacagctc atgctggatg gtcagcagct cggctgtcag atcttcaaag 2828401 ccgggctgcc cggaaagctc tgccaaagca agcccgataa agctgttaag ctcgtcaatc 2828461 gtgccgtagc tttcgacgcg taggctgtcc ttgtccgttc tgcccccgac taagcccgtt 2828521 tgtcccttat cgcctgtttt tgtatatagt ttcataccct gaatctcctt tacagactta 2828581 ttcaaacaac tcagcagcct cttttataca ttcagctgtc cctttcttta tcaattggtt 2828641 cagccgctgt tctatgtttt ctgattgctg agtttgagtc gcggcgatga gaatatcacc 2828701 tgtgcctcct ccgtctccca gcactttcgt ccgttctgct tcggcagcca taagagcttt 2828761 gatgaagaat tgatctgccg catagccgtt aatcaaaatc caaatcgaaa agccggtctg 2828821 aacgcatatg aaaacggata actctccgtc ttcatatgtt cgatacacga aacggtcaag 2828881 tctttctgaa gaagccatcg cacacgtctc ctgcagttga aaaccgcttt ctgaaagaca 2828941 ggccgtaagt ccttctatcg gatctggctg atctggcagc cgtttatgga tcagcgtcct 2829001 gctccacgaa aaccctgcac cgataggcgt ggaggacaat gttcgaagcg ggatttccgt 2829061 ttgcagaaga atgtcatcac gccccgcttg gagcaatgct tcaaatggga tagactgccg 2829121 cttcacgcta tctttttcag gctgaatcac aatcatcggt ttaggtgagc tttgatgaac 2829181 caaggcggtg acatctgtat cgtacaccgc ctttatgctt tgttctgtaa cagcatattc 2829241 cggtttttgc ttaggcccgg cggtaccgtt tttcataaac atgagcccat cacagtacag 2829301 gcttgcggtg ttcagatcat gaaaaacgct gacagctgcc aatccgcttt ctctcgtcag 2829361 gcgtttgatc agatcaagca ggtctttttg ataagccaga tcgagaaaat tagtcggctc 2829421 gtccaaaaat aaaatacgcg gctgctgcgc caaagcttgt gccaaataca cccgctgctg 2829481 ttcccctccg cttagttcgc gaatcggctt ttgcgcaaaa tcggccactc ctgtttgctc 2829541 cattgcttcc tgtacaatgg cttcaccctt ttcagtctgc tgtctgaaca gccccgtttg 2829601 gaatggatat ctgccaaagg ctacagtttc ttcgacagta aaggtgaagg cttgatccat 2829661 tttttgcggc aggacagcca tgatttgcgc cagttccttc ggtttatagt ccgccagcag 2829721 ttttccggcc agataaaccc tgcctttctt ggccggcagc gtacctgtca gcaagtgcaa 2829781 aagcgtggtt tttccgcttc cattagggcc gagaattcca agaaattctc ccttctccac 2829841 tgttaagctg acattgttga ttaggcggct gtcgccgtat cctcccgaca gcccttctgc 2829901 cttcatcata agcttctccc cccgcgatgc tgccgaatta aaataagagc gaacacaggc 2829961 gctcccgcca aggacgtaat gatcccgatc ggcagttcaa tcggctcaat gatggttctg 2830021 gaaagcagat cggctaaaac aagaaaccct gccccaagca aggcggacaa cggcagtaaa 2830081 tgccgatggt ccgttcccca caaaagcctt gtgatatgcg gaatcacaag gccgacaaag 2830141 ccaatcgtac ccgatactgc cacagcgctt cccgtcaaaa gagatccggc tattaaaatc 2830201 atcatcttcc tctgctgaac gctgactcca agaagctttg ctttatcttc tccatatgtc 2830261 atcacgttca gttcccttcc gtttataatc aataaaatgg ttcccaaaag aaaaaacggg 2830321 agaaacaaaa taacatagct ccagcccctc attgagacgc tgccaagcag ccaatgcaca 2830381 atcggaagca ggttgtctcc tgtcaaggcg atgataagag aaataaatgc gcctaaaaaa 2830441 gagttggtga tgacaccggt caaaatgagg gtggaaacag acatcgaagc atgaacgagg 2830501 cggctgaaga aaaggaccgc cgccatcgtg gccagtgccg cggctacact caaaaccggg 2830561 agtgtaaacc ctccgatgac aggaaggtgc aaacctaaga acagagtcac aacagctccg 2830621 actgaagcac cggatgacac acctagcgta tagggatcag caagcggatt tttcaacaat 2830681 ccttgaaaag cggcccctgc aatagaaaga gccgccccca caagggcggc cagcacaact 2830741 ctcggcagtc tgatattcat cataatatta gtgtacatcg gatcatcaga accgatagag 2830801 ccgccgaaac cttgatgcca aaagacacga aaaacagcgg gaataggaat atgcaggctg 2830861 ccgcaagaaa ttcctaagat gatgctcacg gctaaaaatg agaaaccaat gatatatgcg 2830921 gcataacgat tattccttaa acgtatccgg gtaaatgctt tccgcaagtt cttcgacccc 2830981 ttcgatcaga cggggaccgg aacgtgtcac aagatcaggg tccacatcat atacacgatg 2831041 atgtttcaca gcattgattt cgctccagcc atcgcgtttt tccacagctt tcgctttcac 2831101 accgtccgtt gtaacaattg catcaggatt gagttttacg atcgcctcgt ctgtcatttg 2831161 cacccatcct gtctgatccg cagctgcgtt tttagcatgg atgacattta gcatttcatt 2831221 cataaacgta tcttttccgg ttgtataaat gtcaggatca ggagaaacct cgataaatac 2831281 gcttttctcc tcgtcttttg aaatggtttt cgctttttct tgaatatcct ttagatctga 2831341 tttcatgctt ttcacgagct gatcggcttt tttctccgcc ccgccagctt ctccgatcat 2831401 ttcgattgat ttgtacacct cggagaatga ttgtgcatca ttgacagtca gcactgtaat 2831461 gcccgcgtcc ttcagctgtt tgatggcatc cgctgatgct gacatggaag actcatgggc 2831521 cagaacgaga tctggtttta gagaaatgac tttttcaacg tttacattca tatctccgac 2831581 tttctcaacc tttttgactt cctttggata ggtatcgttt gtggtgacac cgaccacttt 2831641 gtcaccaagg ccgagtgcgt atgtaatttc tgtgttgctc ggcattaatg aaacaatctt 2831701 ttttggctct tttttgatgg ttacatcttg gtttgacgca tcatcaatgg tgacagggaa 2831761 cacttctgtt ttttgttttg cctttgaatc cttctgatcc gcaggattgc cgcagcctgc 2831821 cagcataaca gcagccaaca gaagcgcagc ccatatcccg gctcgttttt tcataatctt 2831881 ttcctcctaa acgaactaaa aaagcatctc tacgacggta aagatgctgt aaacaacaca 2831941 aaaaagccta ttgtttacac atcatctgtc ctcgcagaat tcgtgctgat caaacaggca 2832001 ggtatcctgg ctcttggcgc ttggccaatt acagtggcgg gaccgcaccg gcttttaccg 2832061 gtttcccttt taagccggct gttgttcacg gaccggcacc tatttgacat tcgtatccgt 2832121 ttttcggagt aattatacta tatgactgac aggcttgtat atgtgtcctg aatgactttt 2832181 ccccatattg tgtatggaag caaaatcctc gtaaacacta aatttgatct tgtatactta 2832241 ataccatcat ctatcaaaag gaatgattct tatggattta cagctaaaag aaaaactcgt 2832301 cttaatcacc ggctcgacgt ccggtatcgg gaaagccgcc gcaaaaagct ttctgcaaga 2832361 gggtgcggca gtcattgtca acggacgcaa acaggagact gtcgatcgca ccattgaaga 2832421 gctttctggc tatggaacag tgcacggtgc tgctgccgat ttgtcaaaaa cagatgaagc 2832481 agcggctttt atcgaaaaag taaatgaaat cggtgatatc gatatccttg tcaacaacct 2832541 tggtttcttc gaggtaaaag acttcgccga tgtgacagat gaagagtgga atcaatattt 2832601 cgaagtgaac gtgatgagcg ccgttcggac aagccgtcac ttccttccaa aaatgcttgc 2832661 caaaaacagc ggccgcattt taaatattgc aagtgaagca ggcgtcaaac cgctgccaac 2832721 gatgattcca tactcaatga caaaaacggc actgatcagc ctttcaagag gaatggctga 2832781 aatgacaaaa ggcacaaatg tgacggtcaa ctcagtgctc ccgggaccta cttggacaga 2832841 gggcgtggcc tcctatatgg aaggcgccgc acaagcagcc ggacaggata cagatacatt 2832901 tatcaaagac tatttcaagg tcaatgagcc aacctcactt attcagcgat acgcgacagc 2832961 agaagaagtc gccaacacaa tcgtattcct cgcgtctgac gccgcatccg ccattaacgg 2833021 cacggcacag cgtgtggaag gcggcattat ccgttctctg tagtataaaa aaacgcatcc 2833081 gtgtttcgga tgcgtttttt ttatacgtct ccagcaaatg gtaccggctg atatccgcct 2833141 gtttccagtt gtgctgaaaa caaccctcca gcgtgaggct gctcgtatct ctctttttct 2833201 gtcatttgtt ctgttgccgt tgtaatgtaa agggttttta agtctctgcc gccgaacgcg 2833261 cagcacgtga catatttagc cggcacgctg attgaattga tttctttttt ctgaaacggg 2833321 tcaatgtgaa caacgcggct gccgccaaac agcgccaccc acagcatgcc attttggtca 2833381 attgtcatgc cgtccggcaa tccgtctgac tgatcaaaac gatagacagg ttctggattc 2833441 gaaacatctc cgctttgagg atcatagctg taacgtacaa tctcctgggt cggcgtgtcg 2833501 atgtaataca tcaaattccg ctcgcggtcc caatccaaac cgtttgaggt ggagacttga 2833561 tccttgattt tgacaagact gccgtctaga ttcaaacggt acagcgacgc ctgtttttgc 2833621 tcgccttcca tgctcgtcgt ccccgcccaa agccttccgt acgggtcaca tttagcatca 2833681 ttaaatctca ggctctcatg catgtccttc ggctgtttaa ttttttccaa gctgtcatcc 2833741 cgaagatgat acaggtaaaa cccgtccttc atcgtcataa tcagttcatc ctttgaatat 2833801 ttcgcaagcg ccgtcacaaa ggatttgaat ttgattgatc ggttgatttt ttcttcaggg 2833861 tcaaagatgt ggagctcgct ccccaggata tcaacccaat ataagcggcc gttctcttca 2833921 tcccataacg ggccttcacc aatcactgcc cgagtgtctg cttccaatac tgcatccatg 2833981 tgttacacct ctttagcttc agtctatata ttgttattcc cggcaaagag gtgtccaaac 2834041 cacttgatgt ttattgtttt ttaaaaagga tggtaatgac cgttccaatg ttcgttctgc 2834101 tgttcacatg gatcgttccg ttatgcagat ggacaagctc cttggcaatc gcgagcccga 2834161 gacccgttcc ggcagttgaa tcttttgtgt tcgtccctct gtagtagcgg ttaaacaaat 2834221 gggtgatcgt ttcttcatcc attcctttcc cattgtcctt cacttttaaa gaaatatgat 2834281 tttttgtttg ctccagaatg acttgaatct ctgttccttt gccgttgtgc ttcacggcat 2834341 tcccaaggag gttttctaat atgcgcctga accacgcttc atcaagggca aattcaatat 2834401 gctcttcttt ggatacaaac gagatatcat agccttcaga aaacggattt ttcttaaaat 2834461 cctcaatgac atttttaaaa aacgggataa ggctagtgag ctttctctca ataggaagag 2834521 catcattttt caggcgatac gttaaattta agtcttcaat cagcttagac atgtattcag 2834581 atttttctct gacaacctgc cccatttctt tcacttcttc cggcgaccag tcatactgct 2834641 tcgactcgag catcatgctg tagccgtaaa tgctgctgag cggtgttttt aagtcatgtg 2834701 acaaaccggc aatccattct tcccttgtcg cctggatttt ttctctgttt cttttatccc 2834761 ttctcagcgt ttcagtcagc tgatccattg attcaaatat ctcaccgaag aagcggtacg 2834821 gctgtttgat ttttcccttt ttatttttgc tgacaggacg gccttcccgg tttctgggct 2834881 cctcaagctt cccttttgac agattgacca gccatctaat cgtgtgaaaa atcggcagcc 2834941 cgaatcggaa catataccaa acggtcatcc aaatgatata catgaacaaa acggccatca 2835001 cgagaaacat cgcttttaat acaaccttca ggaatgattt gttaaactcc tgatcggtta 2835061 catagactgg gttcggcacc gtagcgacca tccatctgtc tttattgagg atcttaacgg 2835121 aaatttcccg cttatagttc caaggcttag agctgtattt aagcagctcc agctggttca 2835181 tcgtttttct ctcgcttttt gtgctgttga tgctgtcgag aatctttcca ttgctgtcta 2835241 acaggtaaat ggcgcctttt ttccgtttaa tatagtcgat ggtactagac ttatagtgcg 2835301 ctagtgagtc tatcttttgt tcacgctttt caacggaagt caggagctgt tcactttttg 2835361 atttccagcc ggacaataga agatacgact tatcttcaat attgatggcc caataattca 2835421 gtttatagtt atgaagcttt ttggttttat aaatagacaa aagctctttc ttggtatagg 2835481 tgcccggcac gtcttttggc acgccgtagg aataatcagt gtttccttcc gaatcaatga 2835541 tttgcatcca gccgtgctgt ttatcaacag atttcttcag gaaattatcc acttcccatg 2835601 tcccgtcttc gtttacatcg agatatgcct caagtgtgtc ggtcgttgct ttcgtcagcc 2835661 ctgaattgga ttccgcatcg ctaaaacggg cgtctaaata gaaaaacgat gcaacaagca 2835721 taaccgtaag cagcaggatc acaatcagca tctggccgaa aaagtgaaac aaaaacttcc 2835781 atcttaacct catgaccgct tgccttcagg atttgggata aaacgatagc cgagacctcg 2835841 aacggttaca atatactccg gattgctcgg atcgcgctca atcttctccc taagcttgcg 2835901 aatatgaacc atgacggtgt tgttgtcacc gtaggaagga tagccccata ctttttcata 2835961 tatttgatct ttggaaagca ccacgttagg gtgttcacaa aaatactgca aaagctgcag 2836021 aagctgggct gaacaggcaa cggcttcccc gcctacgatc aactcggcat tttgcggaga 2836081 aaaagtaaag taatcatatg tgtaggtttg atttgaactc gtttctttcg attgatatgt 2836141 acgcttgaga tgcgctctga tccgcgccgc taattccagc ggattaaatg gttttgtgat 2836201 atagtcatca gctccaaccg caaagcccga taatttgtcc gcgtcggatg atcttgccgt 2836261 caggaaaaaa atcggagcgt ctgaatactc tctgatcaat gtgcaggctt caaaaccgga 2836321 cattccgccc atcatgacat ccagcacaat caagtcaacc ttattggcct tcacaacggg 2836381 aatcgcttct tctgcgcttg ccgcatccag tatatttcga taaccttctt tttcgagaac 2836441 gcgtttgatc atgtccacaa tcgctttctc atcgtctacg attaaaattg acgcattttc 2836501 cacttttatg ttcctttctg tcactgtttt tttcatctta tcattatatc gtttatttat 2836561 ggtacatttt tgaatacatt ggagccttgg caaatcaaaa cagcaaaaaa ggagcaaaca 2836621 agcgctccct tttgatgttt tttcatatga aaatattatg agttctcatc taccatgtac 2836681 aaaataaact cccaaaaccc cggtacatcc tgacataaaa gcatatcagc cttttcaaac 2836741 attttgatct tcagctcttg ctctaaatct tctctttctt gataggacgt attgctgagt 2836801 ttttttctga tcatcggtga aaagcatgca atcaggtgct caatgtcata agtctcgtct 2836861 ttttgtttct ttttttgttc aaactggccg tccacagctt acttttcccc ctttttttgc 2836921 gccgctaact gctttctgat attctccagc ccctttttat gaatgttgga gatgttttgt 2836981 cgggactccc ctaatgaatc tgcaatctcc tgcatcgtgg caccgtgaag atagactttc 2837041 gtcagcacac ttttttgttt gtcagtcagc ttctggatcg cttggtagag ctggtaatcc 2837101 tgtacatgct ggctcaaatc atcctgcctg tctaaaaatt cttcaaatgc atcgctacct 2837161 gtttcggaag aaagccgatc tcccgcctcc ggatgatcaa ccgtcagtgg ataccgtttt 2837221 tggtttttgc gaacccgctt atcaaaatca atagaaaaga tgcgaatcat tgaattcata 2837281 tacttgacga tgcggatttc tttataaaat tgcttaaata gctcgtccaa tgatcttgca 2837341 tctttttcgt tagggctttc cattacgttt ttgaacaaac ggtaatgctg aggattgctc 2837401 aaaaaatgct tcacgatggg atgcttcatt atctccttac attttgaccg taaaagactt 2837461 tgatagtcca tcaaaccgcc tccctactaa attaaatgaa ggaaagcaaa aaaaagtaaa 2837521 ctactacttt ccgcctagtg tcttccaaaa tactttgcag cagtttacgt tttatcggtt 2837581 ttcctcactt acatacatga ctgcagaaaa agaagggagg tattttccta tggatcaggt 2837641 ttttatagag gaagtcgtaa aacagatcgg caatttgggg tttcccgcgc tgattgcaat 2837701 gtatctgctg acccgattcg aaaagaagtt tgatcaacta atagaactaa tgacagaact 2837761 gaaagatcat gcaaaaaaat aatttttcaa tcgaagttga cttttcactg gtttttttca 2837821 cttaacaaaa cagaagggaa aacgaaaggc ctttcacctt ctctttctgc tatcacattt 2837881 aaatgtaagg aggaaacatt tcatgaaaaa acaaaatgac attccgcagc caattagagg 2837941 agacaaagga gcaacggtaa aaatcccgcg caatattgaa agagaccggc aaaaccctga 2838001 tatgctcgtt ccgcctgaaa ccgatcatgg caccgtcagc aatatgaagt tttcattctc 2838061 tgatactcat aaccgattag aaaaaggcgg atatgcccgg gaagtgacag tacgtgaatt 2838121 gccgatttca gaaaaccttg catccgtaaa tatgcggctg aagccaggcg cgattcgcga 2838181 gcttcactgg cataaagaag ctgaatgggc ttatatgatt tacggaagtg caagagtcac 2838241 aattgtagat gaaaaagggc gcagctttat tgacgatgta ggtgaaggag acctttggta 2838301 cttcccgtca ggcctgccgc actccatcca agcgctggag gagggagctg agttcctgct 2838361 cgtgtttgac gatggatcat tctctgaaaa cagcacgttc cagctgacag attggctggc 2838421 ccacactcca aaagaagtca ttgctgcgaa cttcggcgtg acaaaagaag agatttccaa 2838481 tttgcctggc aaagaaaaat atatatttga aaaccaactt cctggcagtt taaaagatga 2838541 tattgtggaa gggccgaatg gcgaagtgcc ttatccattt acttaccgcc ttcttgaaca 2838601 agagccgatc gaatctgagg gaggaaaagt atacattgca gattcgacaa acttcaaagt 2838661 gtctaaaacc atcgcatcag cgctcgtaac agtagaaccc ggcgccatga gagaactgca 2838721 ctggcacccg aatacccacg aatggcaata ctacatctcc ggtaaagcta gaatgaccgt 2838781 ttttgcatct gacggccatg ccagaacgtt taattaccaa gccggtgatg tcggatatgt 2838841 accatttgca atgggtcatt acgttgaaaa catcggggat gaaccgcttg tctttttaga 2838901 aatcttcaaa gacgaccatt atgctgatgt atctttaaac caatggcttg ccatgcttcc 2838961 tgaaacattt gttcaagcgc accttgactt gggcaaagac tttactgatg tgctttcaaa 2839021 agaaaagcac ccagtagtga aaaagaaatg cagtaaataa aagacttgcg gcttgcagag 2839081 agcactcgtt ctctgcaagc cttcataagg agctgaacca gtgaaacatc aaaacccttc 2839141 aaaacgctta ttgcggctct ccataaagta cttgctggcc gcagcagcag tggtgttgac 2839201 ctattttgct gtcatctata tattgttttc tttagcggga acgagctacc gctcagcagc 2839261 tcatgtcctg ctttttgccg tggtattcct tgttctcgga ttatgctttg aaccatttga 2839321 acggctgatg atacatagct ttacattttt caagacagga aaacgtctat tcattctcct 2839381 tgctggcatc gtacagctgc tgtttttgtg gatgactgct catacaacag accaattgat 2839441 cagcgacatc tggctgtcca ccacagaaga aatgattgtc gcagccgttt ttttgatttt 2839501 agacaaatgc aactcggctc ttcccagcta aaaaaagaac gcattccaat tggatgcgtt 2839561 ctttttattc atagcgaagc gcgtctacag gctgaagctt cgaagccttg atagacggaa 2839621 gcaagccgaa gataatgccg actgccattg aaaagatgag tgctccgaca acagctggaa 2839681 tggagacgat aaaaggcatc ggaaaaatga ccgtcagcag cttggcgatg ccgaagcccg 2839741 ccagcacacc gagtattccg ccaatgcttg tcagcacgac agcctcggtt aaaaattgaa 2839801 ataaaatcac acgccgctta gcaccgagcg ctttcttaat tccgatttcc ctcgtgcgct 2839861 ccgttacgga aacgagcata atgttcatga cgccgatacc gcccaccaaa agtgaaatac 2839921 tggcgatacc gccaagcagc aatgcaaatg actgattaaa ggactccact tcctgcgcga 2839981 tctcctgaag atccattaca ctgtactctg ctttttccag ctcagcttct gacagtccct 2840041 gatttaaaag atctgcagcc attacacccg cttcttggat atgctcagaa gaatcagcct 2840101 gcacggcaat ctgcgttggc gcgtcaaatc cttcaataag cggccacact tttttcggca 2840161 cgtacaaaac cgggttcgca tagtcgcctt caaacatgct ttcctgttga tttttttctt 2840221 taaaaacacc cacgacctta aacggcacac cattcatctc aatgctttta tgcagagctt 2840281 ctccgtctgg aaacagttca tctctgacag cttcattgat catcactact tggtgtgtgc 2840341 tgtttaaatc gttttccgtc agctttctcc cttcggttat tcggattgga aacatgtcga 2840401 agtaatcatc gtccactcca tacacttggg gatacgaaac gttagttaaa tgaaaaacgc 2840461 tcgcgccttc tgacaagtaa tataaggata atcctttgac catcggatct gatttgatcg 2840521 cctttactgt ttcttccgct acaggcggcg cggacgcata cgacacctga gggccgccgc 2840581 tctcctcttc tccgccagac ggctggtaga caacattgat ggcgttgttt cccatgccga 2840641 tcatactttg ctttaactgc tcactttggc ccttcagcat tgaaacaatc gcgatgattg 2840701 ccgctatgcc gataatgacg ccaagcattg tcagaatcga tcttaattta tgagagaaaa 2840761 tggattgaaa ggagattcga atatgttcaa gcatggctga tatcccctct ctcatctaat 2840821 accaactctc cgtctctgat aaaaacggtt ctgtcagctt ttttggcgac gtccgggtcg 2840881 tgggttatca taataatggt cttgccttcc cgatgcagtt cagaaaacag tgccaaaatt 2840941 tgttcacttg atttggtatc aagcgccccg gtcggttcat cagctaaaat aaacctcggc 2841001 tgattgacaa gggccctcgc tatcgccacc cgctgctttt ggccgccgga cagcttaggc 2841061 ggtttgtagg agaccctgtc ttttaatccg actttttcca gcgcttcata tgcccgttgc 2841121 cttctctctt ttttcttcac tttattgtag atcatcggca gctcgacatt ttgcagcgcg 2841181 gtgagacgcg gcagcaaatg aaaagtttga aacacaaacc cgattgattc attgcgaatt 2841241 tcggctaaag ccccgtcttt ccctttcaat atatcgatct ggtcaagcgt ataggttcct 2841301 gaggttggcc tgtccaaaca gccgataata ttcattaacg ttgactttcc agaaccggaa 2841361 ggccccataa tagctaaaaa ctcccccgcc tgaacggtca gattgatatg tttcaagatt 2841421 ggaacttctt cttttcccag cttgtacgac ttcgaaatat tattcagtgt cagcattgac 2841481 tgtaacctgc tttccttcct tgaccgcggg atcaggatag atcacataat cttccggcgt 2841541 caggccgctc ttaatttcca ccatgtcatt ttcatcagtc tctccgattt caacaggctg 2841601 cttaaccgct ttgtgattct catcagcttt ccatacgtac ggttcgccgt catcctgaat 2841661 gaccatgtcg gacggcagct tgatcgtgtc cgcatcagca ttatcactca tcacttcgat 2841721 gttgacatga tagccgactt caagaccttt atggctgtct aataaaatgg tgaaaggata 2841781 gttagaggac tggggattca tttcttcatc agcaaagctt tctgattctt caccctcgcc 2841841 tgctcccgct ggaagcttgc cgatcgaggt gacctttcct ttccactcgc cctcaccgcc 2841901 tgttttcagc gtgaccctga ctttgctgcc ttttttgatc gtgtccatta acagctcatt 2841961 gatttggctt ttgaccagat atttgcctgt cgaaacaatc tggatatacg ggcctgctgc 2842021 ctggtcgcct gttgcaccgt cagcgatatc ctgattgacg ctttgaacga ttccgtcatg 2842081 cttgcttgta atgacattgg aacctttgtt tttcgtcagg ccagccagtt ctttttgatg 2842141 ctgcttcagt tcaagctggc ttgttttcaa atcgaaattg gtttgatcaa gttcatcttg 2842201 aagctggttt ttctcttctt ttcctgcaac tttcagcttt ttttccgttt ccgttattga 2842261 tttttgcaaa cggttgattt gcagatttgt catttcaatt tgcaaattgg cttgctccac 2842321 ttcatcagaa tgatcctcgc cctcatactc aaaaagctta tcgccctttt taacctgatc 2842381 gccttctttg acgtatgttt ttttaatgct gcctttttct gaatctatgt atactttctg 2842441 ctgtttctca ggttcaacct ttccagaaaa cgtttggcct gattctgaat ctcctcccat 2842501 gtataccgcg accgattcag catagggctc cgatgatacg gcaacttggt tcatgtgagt 2842561 aaaaaagtaa aaaccgccag cgccgatccc agccaataca agcacaccgg cacatatcgc 2842621 accgccaata agccattttt tcttcttgga cacaacgatc tcctctttct gtaaactatg 2842681 taatattttc gaaacattct aaccaatatt atctattaat tcaaaaagac ttgcaatcct 2842741 tttattgaaa tgacggaatc aaatagaaaa attgtatttt caaagccgaa taaaaaaaat 2842801 cccggcttca aaccgggatt ttttcataca gtaactagct ctttttcatt tttaatcaag 2842861 tcatatgtca agcatacagg tttatttgta cggggatcag tcacgatttc ggcatcaatc 2842921 tgaaatacct gcttcaaaat gtctggtgtc atgacctcca gagcagttcc ttccttgatg 2842981 accgtgcctt ttttgagcgc gatcatataa tgagaaaaac gagctgcatg gttaagatca 2843041 tgaatgacca ttaaaatcgt ccgcccttgc tctttgttga gtctgtcaag cagctgcaga 2843101 atttcaagct gatgtgcaag atcaagatac gttgtaggtt catccagcag aagcagttcc 2843161 gtcccttgcg caagcgccat ggcaatccac acacgttgac gctgtccgcc tgacaatgcc 2843221 tcaatcggcc gttcagcata ttcagccatg cctgtttctt caagcgccca tttgataatc 2843281 cggcggtctt cgtcatttaa tctgccgaat cctgattgat gcggaaacct gccgtacgac 2843341 accaattcgt gcactgttag gccgctcggc gcttcaggtg tctgtggaag aatcgccata 2843401 tcttttgcaa tgtcctttgt agacatttta tgaatcgctt tgccgtttaa atagacggca 2843461 cctgcatgtg aacgcataat tctggacatt gtttttaaaa tcgttgattt cccgcagccg 2843521 ttcgggccaa ttaaggtggt aattttccct ttaggaatcg atatatttaa atcctctaca 2843581 atcaccctgt cgccataacc gattccaagc tgttccgttg ataatgaatt catattcggc 2843641 cccctcctct aattcgcttt catcaataaa taaataaagt aaggcgcacc tagcacggaa 2843701 atgacaagtc cgaccggaat ttctgatggt gccaatacat ttctcgccag cgtatcagca 2843761 agcaaaaaca ggaatgagcc gatgaaggcg gagaccggta tcagcgtctg gtgacgtgga 2843821 ccggtcagcc ttctagccac atgcggcgcg atcaatccga gaaacgcaat gccccccgca 2843881 gctgccacgc atgaagcggc aagagtgacc gctgccagaa gaagaatccg tctttccttt 2843941 tcaacagcgg tgcccagccc ggtcgccaat tggtctccga gctgcataat gttcaaatag 2844001 cgtgccttat ataaagtaaa cagaagcaag atcacaatcc aagggagaat cgcccagatc 2844061 atattccagt tcgcccccca tattgagccg gatatccaaa ccgcggcttg cataaaatca 2844121 tgagggtcca tcttgagctg aaaaatcagc aacagggcgt tgaatccggc attcacccct 2844181 atgccgacta aaatcagccg aatcggtgtc acgccttttt tccatgccag aatataaatg 2844241 agaaacgcag cgaggattgc tcctgccaaa gcactgaacg gcagcataaa tgttccgaaa 2844301 aagctaagat ctgaagctga cccttgaaaa aagtatataa aaagcactac agcaagtgaa 2844361 ccgccggcgt taattccgag aataccaggc tcggcaagtt cattttgaga cacgctttgc 2844421 aaaatggctc cagctacgga gatccctgct ccaacaagca aagaaaggat gatccggggc 2844481 agcctgaact caaataagac aagttcatca cgcgccgttc cttggccgaa aaagacctga 2844541 agcgttttaa gcggtgcaat tttgataacg cccaaattga gactgataaa aaagaccacc 2844601 acgataagca aaaaggtcac agccattaca atgagcggtt tgtttgtttt tgttttcatt 2844661 acagccctct cctttcacga cgtgccaaat aaaagaaaaa gggaacgccg ataagagaag 2844721 tcagcgcgcc gacaggcgtt tcaaagggcg catttacgag tctggccgct atgtcagcaa 2844781 aaacaagcaa aacagcaccg agcaccgccg agcaaggaat gatccaccga taatccacac 2844841 cgaccaaaaa acgggtaata tgcggaatga tcagcccgat aaatgcaatg gtgccggcaa 2844901 tggaaaccgc agctccggtc agaattacta caataagcat gccaaccagt ttcaccgctg 2844961 atgtatattg tccaagccct tttgccagat cgtcaccgag acttaacact gtaacagacc 2845021 gggcgatgaa aaacgcgagc gttaaaccga cagcccctgc aataagcaaa agctggaccc 2845081 ccgaccattt cacacccgct accccgcctg cgtaccaaaa gctgatatcc tgagcgacat 2845141 caaagcggat tgcaatggca gttgaaatgc cggtaaagaa ataagtaact gccgtacccg 2845201 ccagagcaag ctttacaggc gtaagtccgc cccttgaaaa catgcctatg cccattaccg 2845261 tcgatgcccc cagccccgct cccgcaaagg accatagcac aagccccatt gcagaaagtc 2845321 cgggaaaaaa ggcaaacgca atcgaaaccg caaacgcaga gcctgatgtc acacccataa 2845381 tcgaaggctc tgccaaaggg tttctcgtca tcccctgcat gattgctccc gacactgcca 2845441 acaatgcgcc tacaagcgcg gcagccgccg ttctcggaag ccgaagatca tgtataattt 2845501 ggtgagatgt ctttgtcggc tgataatgaa aaatggcctc ccatacagtg cgcaaatgaa 2845561 tatccgctgc acctagggat atggataaaa atgcgccaag gcaaagcagg catagacctg 2845621 cgataaggac gatgaccgcg ccatatgtcc ttgacgtcca ttggatttct tctgatgcag 2845681 tccgtatatt tttatgttga ctcaactgcc gtacttcctt tctgttactg ataatgatta 2845741 tcaattgctg tttcagtata tcactttttt cagctgattt aatagagtgt tttgaacaaa 2845801 aatgaaaatg catttgcaaa aatatcgtgt caaccggcac ttgcagtggt ataatcacag 2845861 atgataatga ttctcttttt catctatctt ttagaaagaa ggtatgagat atgacccata 2845921 tatacaagaa actcggagcc gcgttttttg ccctgttatt gattgcagcg ctggcagcct 2845981 gcgggaataa ctcagaaagc aaaggttctg cctctgattc aaaaggcgca gaaaccttta 2846041 catacaaggc tgaaaacgga aatgtaaaaa tcccgaagca tcctaaacgg gtggttgtca 2846101 tggcagacgg ctattacggc tacttcaaaa cactcggcat caacgttgta ggtgcgcctg 2846161 agaatgtatt taaaaaccct tactacaaag gaaaaaccaa cggcgtcgaa aacatcggag 2846221 acggcacttc ggttgaaaag gtcattgatt tgaaccctga cctgattatc gtctggacaa 2846281 cacagggcgc tgatattaaa aagcttgaaa aaattgcgcc gactgtcgca gtaaaatacg 2846341 ataagctcga caacatcgaa cagctgaaag aatttgcaaa aatgacggga actgaagata 2846401 aagctgaaaa atggctggcc aagtgggata aaaaagttgc ggccgctaaa acaaaaatca 2846461 aaaaagcggt cggtgacaaa accatttcca ttatgcaaac gaacggaaaa gacatttacg 2846521 tatttggtaa agactttgga agaggcggaa gcatcattta caaagacctc ggcctgcagg 2846581 ctacaaagct gacaaaagaa aaagccattg accaggggcc aggttataca agtatttcat 2846641 tagagaagct ccctgacttc gccggagatt acattttcgc gggcccatgg caatcaggcg 2846701 gtgatgatgg cggcgttttt gaaagctcca tttggaagaa cctgaatgcc gttaaaaatg 2846761 gccatgtata caagatggat ccgatcggat tctatttcac agacccgatt tcattagaag 2846821 gacaactgga gtttattacg gaaagcttga ctaaataaac aaaagagccg cctgcccgcg 2846881 gctcttttgc ttatttataa ggaacggctc aatttgaatc atatcggata ttttctttga 2846941 gccattcata ttaagctgca tcctcatcac gatcagtttt tttatgctgg agagactgaa 2847001 aaacgttttt tgcatattta acgaacggat tcctaacagg agaaattgtg attttataaa 2847061 aaagacacct gagcaaatca ggtgtctttt cattatgctt gtttttcttt ctggaacttg 2847121 ttactcacaa atggataaac gattaagccg acaaagaata aaccgatgcc gagtataaat 2847181 gtcgttaaat ctgctgtgcc tgttacgata acaaacacgg agtatgcaca cgccagtatc 2847241 gcgatcaatc cgtctcttac acgggagcct ttcagctggt catacgtttc acctttgatg 2847301 actaccttca agctgtagat tgcagatacc agatacggaa ttaaatatgc gagtgtagcc 2847361 gctgtcgtta aaaatgtaaa tgcgtcactt attgtccggg aaataaccga gaaaatgaag 2847421 acctgtgaca tgacgtttgt aataatgagt gcaatgaccg gacttccctt tttattcgtt 2847481 tttgcaaaaa atgccgggaa atctcctgct ttagcggctt ggtatggcac ctcagagcca 2847541 agcaaaatcc agccgagcat cgttccgaat aaacaaagga tagccaaaag cgccataatc 2847601 acgcttcccg cgtttccaac aatcgcatag agtacatcaa caaatggttt ttcagagccg 2847661 acaagcttat catgcggcag aacacccatc gtaattaaag tcacaataat atatatgctc 2847721 aaggcaatca gcaagccggt aattgtcgca cgtttcacat cacgctgaga gcgcgcacgg 2847781 ccggacagga tcaccgcgga ttcaattccg acaaacgccc acagtgtaga aatcgcagcg 2847841 ttatgaacct ggccaccaat tccaatgctt gtgccgtttt ctccttgaac cgggaaataa 2847901 aaatgaccga ataatgacgt ttgaaacaca aacaaaccgg caacgataaa gaagacaaaa 2847961 cctaatactt tagaaagcgt tgtgacaaag tttaatttac ttgcgccgtt aatgctggca 2848021 acaagaatcg cgtgcgttcc ccataacaag atcgtacata cggcaaacgt cagtaattgg 2848081 ccgagtgtca cctcttgccc gccgatcgaa aacatctcac gtttatcaac caagatcggg 2848141 aagaacgaag tcaagtaacc ggcgagactt gtgatgatcg ccacgttact gatccagctc 2848201 gccacccagt agccccacac cattgtgaaa ccggcagcgt tgcctttttt cgggtcagaa 2848261 aacagcgctc ttgcataact ttgcggtccc gctgtcagtt caggcttgcg aatggacaag 2848321 tgtccgaaca caagtgcaat catcagcacg ccggcacctg tcaaaagcca ggcggacgta 2848381 gctccaaacg gactcgcaat tgaagcaagc gagctcggca aggagaaaat tcctgatcca 2848441 accatatttc caacgacaaa cgccgttaat aaccaaaaac cccatttttt tgtctgttcc 2848501 attccagtac ctccatgatt ctttgtacgg accagacccc gagatcatat aaacgcaaaa 2848561 aaagcctgaa caaaagtcca tgcttaaaga aacacacacc cttgatctcc ggatagccct 2848621 ccgcgaaaaa gcacgcggca gtcctgcact tattcagata cagtcccagc atagagaagg 2848681 atcggctttc tccacacttc ggcgctgatg ccttttacac atgtttaaca gcccctgtca 2848741 gcctagcatg tgtgactcat catccgcgca acctctacct cactgagaaa gagtgaggat 2848801 ttaattattc agttactccc agaaggttat caaagaaagg atgatctgtc aaagggaaca 2848861 gatggaaaat acggatagag ccaagcccta tccgcatgtg gttatcgatt atttttcttt 2848921 ttttgcacag cttcttgaag cggatcatct tttagagctg aaccagcatc ttcaagagct 2848981 ccttggatta cgtttttttc tttttcggaa cgttttcctt tatctttatt aaagaaaccc 2849041 attcgtatca cctcttttaa aaaataggta catgtttaag atgccttttt cctgaaaaat 2849101 tatgcgggat attttttatc gtccaaagtc ctgttgatca aacatacatt ctcttgatat 2849161 atttgtaatt cagagatttt ttgcaaaaga taaaaggaga agcggcaaat gacaggaaaa 2849221 acacacatca tgggaggcat cgcttcttgt acggcagcgg cttattatta tggatttgat 2849281 ccagtgctta tggctgcgtc aggcgcggtt ggagcattaa tacccgatat ctgccacaca 2849341 caaagcaaaa tcgggagaaa atttcctatt ttatcgaaag tggtcagctc cgtttttggc 2849401 catcgcacct ttacacacag cctgctgttt atgctcatca tgttttttat cacttctaca 2849461 tacattccag ataaaaacat atcagccggc ctgatgatcg gaatggcgag ccacttgatt 2849521 cttgacgctt ggacggtgaa cggaatcaaa ttattattcc cttccacgat ccgcgttcgg 2849581 cttccattat atatgaagac aggcagtttt tctgagcagc tcgtgctagc cggcctgacc 2849641 cttgcttcat gttactactt ttatatgctg tttcatggcc gcatgtttta aacatgagtg 2849701 ctgagacttg tctgaaccgg ctgtttttag taggttttac ttaagaagca tttcatgcag 2849761 atgatcaaga aaacgtgagg agtcatattg atgaaaggaa ccttttttca caatcagcgg 2849821 tttttatgtt tttcgatctt atttatgtgg atcaaaacgt atgtgatata taaactcggc 2849881 tttgatttgc aaatcgatac tctgttggag gagctaatgc tgctggtcaa cccgctcagc 2849941 tttattcttc ctttattcgg gatcggcctg tttctaaaag aaaacaagca gcgggccttt 2850001 ttgctgattg ccaatttggt tctgactgtt atcttgatct ctaatacgat tttttacggc 2850061 ttttatatcg attttattac catcccggtt ttatttcagg ccagcaacat gagcgatatg 2850121 ggcagcagtg taaaagaact gttccatcct ctgtttatcg ccctgtttgt ggatttggtt 2850181 tttctgctgt tgttcgccag aaaaaccaaa cacccacaga caaaagccgc tccccacacg 2850241 atcaaacggt actatgcagc ttcctgcgga atgcttttat gcacactggc acttgcagaa 2850301 gtacagcagc cgaagctttt ggcacattct tttgaccggg aaatgctagt caaaagcatc 2850361 ggcctgtttc agttccatat ttacgataca atttctcaga ctgttaatat cagcgcgaaa 2850421 gcttttgccg atgaagacag tataactgcc attaaaaact acacagaggc tgattacagc 2850481 aagcctgatc aaagcaaatt cggtcttgca aaggggcgca atgtcatctt tgtaacactt 2850541 gagtcgaccc aaagctttgt tctgaatgaa aaagtaaatg gaaaagaaat taccccattt 2850601 atgaatgatc tcataaaaaa aagctattcc tttgatcatt tctatcagca aacagaacaa 2850661 ggcaaaacat cagattcaga atttatcgtc gctaactcac tgtatccctc ccttagcggc 2850721 gccgtctttt tcacgaaaag cgaccatcaa tttcatacga tgtataaatc gctgaagcag 2850781 cacgattatt attcagccgt ctttcacgct aaccataaaa cattttggaa cagagatgtc 2850841 atgtacgata catttggcat tgaccgcttt tttgatgttg atgattttca tgtcactccc 2850901 gggacatcga caagctgggg cttaaaagac aaagaatttt tagagcagtc cgccaaaaag 2850961 ctgaaaagcc taccgcagcc gttctacagc agttttatca cgttaacgaa tcattttccg 2851021 tttgagattg atgaaaagga tcagctgata gatgaattcg attcaagcag tgatctgtta 2851081 aaccgctatg tgaccacggt tcgctatgag gatgaagcat tgaagcattt tatcaaaaaa 2851141 ctgaaggacg aaggcttata cgaaaattcg atgatcgtat ttatgggaga tcattacggc 2851201 atttctgaag cccataacga ggcaatggct gagtttttag ggaaagacga aatcacaccg 2851261 tatgacaacg ttcagctcca gcgggtgccg tttatcatac atatcccggg aatcaccgat 2851321 caacagccgg aaaccatccc tgatgccggg ggacaggtcg acgtcaggcc gacgctgatg 2851381 catttgctcg gcgttgagac aaaaggcgat atccaattcg gcaatgattt gctgtcgggc 2851441 gaccgcaccc cattcgccgt tctgcgaaac ggcagcttta ttacgaacga ttatgtatac 2851501 acaaagaaca cgtgctatag ccaaaaaaca ggtgaagtgc tggaagatca ggatgcgtgc 2851561 ctcccttaca aggagaaagc aaacgaagaa ctgtctctct ctgataaaat tttaaatggt 2851621 gacctgctca ggttttccga atgaaaaaat ccctctatca agagggattt tttacgtttc 2851681 caatatcacc ttgccagtca gcttcgtttc atagccgttt aaatgagaca gattcgcctt 2851741 gtagtcctca gaattcaaaa tctccttcac ggctttgagc aactgctcat tttttttcaa 2851801 aacaacgata tcatattgtt cgtcgatgag cgggataaaa tcaacactgc ccatatgtgc 2851861 cgcgtgctgt gccccgattc ccgcgtcagc ctgtccgctt gaaacttgtg aagcggcagc 2851921 gtaatgatca gtcacgatat cgccatatcc cactacatca gccggattca caccaagcaa 2851981 gccaagctgt tcatcaagga gcacccttgc gccagaaccc ttttccctgt tgatgatccg 2852041 gatatcggct cttttcaagt ctttccagcc ttgaatgttt ttcggattcc ctttttgcac 2852101 atacagtcct gctttgcgga gaacgacatt gatgagacaa aacggttcac ctgtcaaaat 2852161 ccgttttaca taaggcgcgt tatactggcc cgtttctgca tcgtacaaat ggaggctgac 2852221 aatgtcacac ttgccttgat acatatcaat caggctgttt aagcttcctt tgtatttacg 2852281 gagcggcgtc tcctgaatgg cattctccaa atgcttgctg aggatatcca tcgaaatgtc 2852341 ctgtccgctg atcatgacat ttggtctgcc gtccggctca gcctcctgca cctgtttcgg 2852401 cgcttctttt gcagcgatgg gctgagacat tctcatattc gttttatatt gctttaaatc 2852461 ttcttcatcc acacgcatct gccttccgac acggtaagca ggcagcacgc cttttttaat 2852521 caagtcataa acggtcagct ttgatacctt cagcagacct gcaacttctt ctatcgtata 2852581 ggaagaggtt tcattcatca tcatcactct cctattttat tatacctttt cgccgaatgt 2852641 aaaaaaaccc acataaacca aacataatca gttataatta gttatatcta atgataaggg 2852701 gtgcaatcat gtttaagaag tattctattt tcatcgcagc cttaactgct tttctgcttg 2852761 tagcaggctg ttcttcaaac cagtcttcaa cggacagcga gaaaaaagta acgttaacca 2852821 tctcagctgc cgccagcgcg caggatgcac ttgaggaaat ccaaaaaaat tatgaaaaag 2852881 atcatcaaca tataaccatc caagataact atggctcatc cggcgccttg caaaaacaga 2852941 tttctcaagg agcaggagca gatctgttct tctcagctgc tgaggataaa tttaaaaagc 2853001 tggtggatga tggagatatc gcaaaaaaag acagcactga attagtcggt aatgaaattg 2853061 tgctggtcgt accgaaaaac ggagattcac ctgtgacaag cttcagcaat ctggctgaat 2853121 cagaaaaaat cgctcttggc actccggaat ccgtaccggc aggagcttat gggaaagaat 2853181 cactgacaaa gctgtcttta tgggacaaag tgaaggataa aattgtgtat ggaaaagacg 2853241 ttcgccaagt tctttcttat gttgaaaccg gcaatgtaga cgcaggtgtt gtttataaaa 2853301 cagatgccct agtctcgaaa aaggtcaaca ttgttgacga ggcaaaagca gatacacaca 2853361 gcccaattgt ctatccgtta ggaatcgtaa aagatacaaa acaccgtaag gaagcgaagg 2853421 aattttacga atacctgcaa tctgatgaag caatgaaagt atttgagaaa tatggcttta 2853481 ctgccgagta gcataagcgc ttcagaattt ttcacacccg ttgtgctttc ctttcaggtg 2853541 gcggcagttg ccggaattgt tgtcattatt ctcggaacac ttgctggagc atggatgtca 2853601 cgggcatcat ttttcggaaa aacggcactc gaaacatgtt ttatgcttcc gctcgttctt 2853661 ccgcctactg ttgtcggttt tattctgatc gtcattttcg gaaagcacag cttcatcgga 2853721 caagccatcg agtggatttt ccagcagcct gtcattttca cctggtgggc cgctgtgatc 2853781 gcctcggctg ttgtagcctt tccgcttatg tatcaatcag ccaaaaccgg atttgctgac 2853841 attgatcccg atatacaagg tgcggcaatg gtagacggcg ctagcagatg gaaagtgttt 2853901 atccatatct ccgtcccgct tgcctatcct tcgttactga ccggaagcat ccttagcctt 2853961 gcgcgggcgc tcggagaatt tggcgcaaca ctcatgtttg caggaaacat ccccggtgtt 2854021 acgcaaacac tgccgacggc gatatatgtc gcattggatt ccggcaacaa tacccttgct 2854081 tgggcgtggg tcgtctgtat tgttgtcatt tcctttttga tgctgttttt cattcaacag 2854141 aaaaaaacgc actaaaaaaa ctccccataa cggggagttt tttgattaaa acagaagctc 2854201 atcaggattt ggaccgacac gctcatcttt atttaatgcg tcaattttgt ccatgtcttc 2854261 ttgagacaat tcgaaatcaa aaatatcagc gttttcgatg atacggtgtt ctttaatgga 2854321 ttttggaatg gttacaactc catgctgcag atcccagcgc aaaatcactt gagccacaga 2854381 tttattgtgt ttttcagcaa tctgtgtcag tacttcgtta tccaaaagct gtccctgcat 2854441 gagcggagac cacgcttcca gctgaatgcc ttgccctttg cagtaatctc ttaattcttt 2854501 ttgcgtcaag cgagggtgaa attcaacttg gttcaccatc ggtttgattt cagcatcttt 2854561 caacagctct tctaaatgat gaacttggaa attgctgacg ccgatcgcgc gaattttgcc 2854621 gtctttgtac agcttttcaa gcgcgcgcca tgtatcttta tatttatctt tgccaggcca 2854681 atggatcaaa tataaatcta agtaatcaag ctgcagtctt tctaggcttt tttcaaaggc 2854741 agcaagcgtt gtttcatagc cttgatcttc attccacact tttgatgtga tgaagagctc 2854801 ttctcttgcc acaccggatt ctttaatccc gatgccaacg ccttcttcat ttttgtagat 2854861 cgctgctgta tcaatactgc gatagccatt tttaattgcc gctttcactg attcagtcgc 2854921 ttcattacca ttttctactt taaaaacgcc cagaccgaac caaggcattt caactccgtt 2854981 atgtaacttt acagtatctt ttaaacttgt tggcacttga acctccaccc tttcactgaa 2855041 atgtaagcgt ctatattatc tcacattcct ctcagccgat accaataata cgcttaagac 2855101 cctctttttg cttctttttt cacagcacag gcaaatccaa acactatttt tttcctattt 2855161 taacaatatt gagattacaa atacattgag cagggtatgc gtgtagtgta accaaatgaa 2855221 aacaaaggag gaaacaactt gaaacgtatt cgtatcccaa tgacacttgc tcttggtgcc 2855281 gctttgacaa ttgccccttt gtcctttgct tccgctgaag aaaatcctgc tccgaagatg 2855341 tcgcagacaa ctactgctgg aacaactgcc gctgatgtag gtttaaacgt caacctggat 2855401 gtacttggaa ttgccaacca gatcgctgat gccatcaaat ccgcacagaa tagggatggc 2855461 tttgtgaaaa acctcatgga gtcttccttc tacgcgtccg gccaaaaata taacgtcatg 2855521 gtctttaatt taagccagga atatgaagat catttgaacg gtgtgcaatt ttacggctca 2855581 gccgtttacg acggcattac gtatggcatt tgggtatttg aagatggaac ctttacaaac 2855641 aaaggcgatg gcggctggat caactgggcc ttcagaggct ggttcgaccg ggatggcagc 2855701 actgtcgcat ttcatcgccc ttaatataaa aaaagctggc gctctaacgc cagctttttt 2855761 tctgcattta ttcgccgcct tcaagcatgg cggcttcgac atcattaatg tattggcgaa 2855821 gctcatggga gatgtcccgg gaaatttccc tctcttcgaa gagcgtttga atttcatttc 2855881 tgatcgcctg cacagccttc agcttcactt ccagcttctg attttcaaaa tgggcacttg 2855941 attttaactc atgatggctg tgctccagcc tgaaaattaa ctgcttatag aatgtaatga 2856001 cagataaaaa cacttcttta tgctcatccg tcttatgttt ttccagatat tctatcgctg 2856061 cttttgccgt tttcactctt gttgcccgta tcaatcccgc ttcatttaaa atcgacatct 2856121 ccggcttttt atgttcaccg aagaaaatcc aatacatcag cctcttgagc cttgtttttg 2856181 ataacccgac tttaaacggg ttggcataca aaatttccaa ctcgttaaat cgttcttgca 2856241 gcacatttgc tgtttcttcc gggatgtctc cccgctccag cattttcatc agcgcctctt 2856301 gctcagcctt aaccccctgc gcacggactt ttcgctcgtg cttcttaatg cgattagatg 2856361 atgtatactg ctgaaaacga agatttttca ttttctcatt gtattcagct atcaccgcaa 2856421 gagaggccgt tttgtttgtc tcattcatgt cctctttaat cgtttgaagg gctgttttga 2856481 tcaacttgcg tctcgccgtc agcagcttct tatttcgttc ctcgtcctct tcttcttttt 2856541 cagtcagaat tggcagcaca acggtggcaa tgacaagcgt gcataaaatg acgccggctg 2856601 ctaaaaagag aatcagattt ctttccggaa acggcgtacc gtcctccagg aaatacggaa 2856661 tggaaaaaga acctgcaagc gttactgctc cacgcacacc ggaaatcgaa attaacagcg 2856721 tcgaacgaag acccggttta tagatgttct gatctttatt aaagaaccat ttgccgttcc 2856781 agaagaacag cacccacagg aatctaagga gcattaatgt aaatgtgatg actaggatat 2856841 agccgatcac cttcatgttg ctgatggcag tgtcgttaaa gataacagaa ataacatcag 2856901 ggatttgcgt gccgagaata acgaagacca ggccgttcaa aataaataaa ataatgttcc 2856961 acgtacttga ggagacgatt tgcagcttga tcatcgttga ttccagacga tcctgttcaa 2857021 ccgcatgggt aataccgcca gctacaacag ctaaaatgcc cgaaacgccg atttcttcag 2857081 ctgccaaata aatcacaaac ggcgtcagaa tttgaatcag catatgcatc gtgacatcct 2857141 gcatgccaag gcggcgcaga aataggcgaa aacgaataat caaaaatgaa atgacaaccc 2857201 cgcacagcaa gcctccgaga gaaataaaga caaagctgac agccgcttgt gctaatgaaa 2857261 atgcaccagt cactgccgct gcaatcgcaa acttaaaggc caccagacct gatgcatcat 2857321 tcatcagccc ctcaccttcc agcaggcgaa gaatcccttt tggcattttc actcttcctg 2857381 ataatgcgct gacagcgacg acatcagtcg gtgaaagaat ggccgcaagt ccaaaggccg 2857441 ctgccagcgg aatagcagga atcatccagt gaatcgtgta gccgcctaca atcacagtcg 2857501 caaatacaag gccgagtgca agcaataaaa tcggagccct taaattccaa agctctgccc 2857561 gcggtgtcct ctttccatca ttaaatagca gaggcgcgat aaaaagaaca aaaaacaatt 2857621 cggtgtttaa ttcaaaatga agtccctgtg gaaatgaggc ggcaagaatc ccaagagcca 2857681 cttgaatcag cggcaccgga ataaacggaa taaaccggtt cacgatatta gaaatcgcaa 2857741 taatcgttaa taatacgagc acaactaaaa atatgtccaa atgcatgacc tccttcgtct 2857801 gttgtgtgtc ggcatgatga gccaaaaaat ctgtttgtct aaaagccctt gagctagggt 2857861 ggccttgcat ccgctatgtg gtttcgcagg agttctctcc acacttgtct tcttttatag 2857921 tacccttttt agggtatttt ttctcatgat atgctcacag tgaacttttt tgcagaagag 2857981 caaattatag aaaaaagaga caggaagcta ctccctgtct ctcgtctttc tttctcaatc 2858041 atgaaaattc gtaccgtcag ttgttgcttt aataatgccc gcgcgaatga caaagtcacc 2858101 gaaatgctcg ccttcctcgc gttctttcgc atagcgggaa agaaggatgc gcagctcgct 2858161 taaaatgtct gcttcaccga tgttttcacg gtacattttg cttaaacggc ttccgtcaaa 2858221 cgcagcgcca agatacatat tatatttgcc cggcgccttt ccgataaatc cgatctcacc 2858281 gagtgcatga cgtgcacagc cgttcgggca tcctgtcatg cgaatggtga tttcctgatc 2858341 acgaaggccg ttttcgtcaa taatctcttc aatcttatct aacagggtcg gcaaataacg 2858401 ttctgcttca gccattgcca atccgcaggt cggaagagcg acgcacgcca tcgagctgcg 2858461 gcgaagcgct gaatagtgct tgccgtcagt tagtccgtac tgttcaatta aagcactgat 2858521 ttcttctttt ttatcgcttg aaacgttcgc aatcattaag ttctgattgg ctgtcagccg 2858581 gaactcacct gtatgaactt tggcgatttc ccgcaagcca gtcatcagct tataatcatc 2858641 gtaatccgtt atacggccgc cttcgacaaa cagcgtgaaa tgccatttat cctcgatgcc 2858701 ttccacccag ccatagcggt cgccgttatg atcgaaatga tacggcttcg cttcttccag 2858761 gctccagccg agacggtttt ccaattcttc ttttacgttt tctaaaccga ggcggtcaac 2858821 tgtgtatttg aaccgcgcat ttttacggac agaacggttg ccgtaatcac gctgaatcgt 2858881 aatcgttttt tcagcaacgt catacatttg ctcaggccgg cagaaaccga tcaccttggc 2858941 taattgcgga tatgtcgcag tatcgccatg cgtcattccc ataccgccgc cgattgccac 2859001 gttaaaaccg atcagcttgc catcctcgac aatcgcaatg aatccgagat cttgtgaaaa 2859061 gacgtcaata tcattagacg gcggaacggc aataccgatt ttaaacttcc gcggcagata 2859121 gagcggtccg tacattggct cgacttcttc ctccggcgtg ccggcaactc tttcctcatc 2859181 aagccaaatt tcatgatatg ctctcgtccg cggcagcaga tcatcactta attttttaga 2859241 ccactcgtat acctctgagt ggatttcaga ttgataaggg tttgatgcac acatgacgtt 2859301 acggtttacg tctccgcagg ctgcgatcgt atccaaaagt gctgagtgga tcgtctgaat 2859361 ggttttcttc atgttccatt tcagaattcc gtgcatttgg aatgtttcac gtgtcgtcaa 2859421 ttttaatgtg ccgttcccgt atttctggga caggtcatcc atgacaagcc attgttcagg 2859481 cgtcgagacg ccccctggca tacgcacgcg cagcatgaac tgatatgcgg gctcaagctt 2859541 ctgcttttgg cgttcatttc ggaggtcgcg gtcatcctgc aaataactgc cgtggtgttt 2859601 catcaggcgg ttatcatcat ccggaattcc cgcactgatt cgatcgagca tcacttcttt 2859661 cagcgtgccg cgcaaataat cactttcttt tttaatgcgt tcaacatcac ttggagagcc 2859721 gtccggtgct tttagaattt tggtcaccat gttgaaaaac tcctttcaag tcaaatcaat 2859781 atacatcacg ctgatagcgt ttttgctgct gcatatcggc aagataagcc tccgcctctt 2859841 cgcggctcat attgccttct ttttcgataa tttcaagcaa tgtgttatgg acgtcatgcg 2859901 ccatgtgctt ttcatctccg caaatgtaaa cagccgctcc ttcttgaagc cattcaaaca 2859961 attctgcgct atgttcaagc atgcggtgct gcacatatac tttttcttcc gtatcacgtg 2860021 agaacgccac atccattttt gtcagcacac cgtctttgag ccaattctgc cactctgtct 2860081 ggtaaaggaa atccgtgaca aagtgctgat cgccaaagaa catccatgcc tttccttccg 2860141 ctcccgtctc ctcacgctcc tgcataaacg aacggaaagg tgcgacgcct gtcccagggc 2860201 ccaccatgat aatcggtgtt tcagggtctt tcggaagctt aaagttttga ttgtgctgta 2860261 cataaaccgg cagtgtgtct cccggctgca gtcgttccgc gcacaaaatc gagcagacgc 2860321 cttttcgttc acggccgtgc gcatcgtagc ggactgcgcc gattgttaag tgcacttcat 2860381 ccggatttgc ggataaactg cttgcaatcg aataaaggcg ggcaggcatt tttcgcaaaa 2860441 tcgagacaaa ctcctgcgca gatacactaa atgggccata gtcacggacg agatcaagca 2860501 aatcgcgccc ttcaatatag gcttttacat tctcctcatt tcccggggct aaaagctctc 2860561 taagctcatc gttccctgtc agctgggctg cctgttcaag aagcggtttt gtgagaacgg 2860621 taatctcata gtgagaaatc agcgcttctt tcagcggtcg gacatcacct tgcttattaa 2860681 gcgtcacaat ttcttccggg tcccaattca tttccttaag gagcagctcg acaagttccg 2860741 gatcgttttc cggatagacg ccgaggctgt caccaggctc gtaagtcagg ccagatcctt 2860801 caagagacag ctccacatgg cgtgtttctt tatttgatcc tctgccgttt aaatttaaat 2860861 tttctaacac ttcagcccga aacgggtttg ttctggaata cgaagactca ccggtttgtg 2860921 acgcagccgc cggcgcaggc gcggcgcttc cgcccccagc ttcatttaat cctttcaata 2860981 caccctcaag ccattcggct gccggttcat catagtcaag atcgcaatca acgcgcggag 2861041 aaatccgttt tccgccgagt tcttctaagc gttgatcaaa ttctttccct gtctggcaga 2861101 aaaattcgta cgaactgtca ccaagcgcca aaacggaaaa gcgcaggtct tcaagcttag 2861161 gcgcccgtct tccgtgcaga aattcatgaa acgacagcgc gttatcaggc ggctcgcctt 2861221 ctccatgcgt actgacgacg attaaaagat tggttacctt cttcagctga ttcggcttaa 2861281 aatcgctcat ggatgagacg gtcacttgaa aaccgctctg ttcaagctgc ttgccggcat 2861341 tttctgcaag cccctgtgcg tttcccgtct gtgaaccata aagaacggtc acttcttttg 2861401 aaacggccgg tgccggtgct tccgctgaca cagctgccgc cggcgtaccc gcagcttctt 2861461 gggcggaaac agattgagcg gataaatatc cgctcagcca gattttctgg gattcggtca 2861521 aggtcggcag aaggcggtta aggagctctg cctgctcctg attaaacgga ctgttcatta 2861581 cctgaagttg caacgtatcc acctcacaaa gttataaact gatcgaaaat tgcatctaat 2861641 tgaactttac cggaatacta ggcttaagta aaatatattt acatgatgat aactattaag 2861701 aatcctaatg ataaaacggc tatgcttcat gtaaatagaa aaaagagaag gactcccttc 2861761 tcttcattca gcaatctgat ataagtgagg cggcacagcg gttacaaacg gactggcttc 2861821 acctgtataa aataccgcca gcatgtgcat cgcacgggtg cacgcagtat ataaaagcct 2861881 gcggtcgtgc tctgtatgat agtgttcttc agatgcatca tagacaagca ctgcgtcaaa 2861941 ttcaattccc ttcgctaaat acaccggaat cacgcaaaca cccttttgaa atggttgatt 2862001 ttctttatga atcaggcgaa catctgtata ttcactcatg tgggcgtgcg cctgtatgca 2862061 ttgatgcgca gtcttgcaga tgacggctat tgtttcgtgc ccttttttct tgagccggcc 2862121 aatttcttgc gcgagctttt ggcaaaggct ctcatgtcct tcagttttga caacgagcgg 2862181 catttccccg cttctattaa acggctcaat atccgctcca tcttgaagca tcgctttggt 2862241 aaactcgaca atctgccttg ttgatctgta tgttctcttt aaacgaacat actcagcagg 2862301 ctcatcctca aagcacgcat ccatacgctg atccccgttt atggtatgcg cgtagatgga 2862361 ctgattgata tcaccgagca ctgtcatgct ggcagccgga aaaatgcttc tcatgtaagc 2862421 catctgaaac ggtgaatagt cctgggcttc gtcaataaat agatgtttga ttttcgtatt 2862481 tttctttctg ccctcaatca gatcctgcat ataaagaaac ggtgccgcgt cctcatagag 2862541 caatttatta tccgtaaatg ccgaacgggt cagctcacct atcgcatcca tcttctcatg 2862601 ttgaaatttt cctccccagc cagaaaacaa ttgcaaataa agttgtgtaa catcaagaaa 2862661 tgcaaggagc ctgactgcct gtttgagcgg tttgaaagct tttttcacaa tgatggcggc 2862721 aagcagctgc tgctctcttt gataatcgtt aaacgtactc tcgctgaacc gtttcctttc 2862781 ctgcagtttt ttgtacacgt ccaagtagtc ctctttgtca agcagctcag cttcatgaac 2862841 aacccaatcc tttcgccgtt cctttttctc aagcttgtta agctcactca gcagccactt 2862901 cgcggtttgc tccatccgat tcggaatgga gtgattttga tccaatgagt aaaaatagga 2862961 ttgaatttgc tcctttgtga tcagcttttg tccgcggaat ataatatttt taaaaatcat 2863021 cccttcagag gaaagccgtg tgacgtattc attaatgaat tgctgaaagg ataaacccgc 2863081 cttccatgtg attcctgcaa gccttgttgg aaaatcgcct ccctttgttt cggtcaggca 2863141 atattcgagc tgatcaaagg ggctttcaca tttgaacttg cggccaagac gatgctcgat 2863201 atattcctga aacgtcgcct gctccatatt ctcttctcct aactccggca aaacagagga 2863261 gacatagctg ttaaataaga agttgggtga aaacaaaacg atttgtccgg catcaatgac 2863321 accgcggtgc ctgtataaca aataagcgac acgctgaagc gcagccgatg ttttcccgct 2863381 gccagccgct ccctgcacga tcaggatctt gcttttttca ttacggataa tctgattttg 2863441 ttctttctga atcgtagaca cgatgttttt catttgggta tcagagtgat ggcttaatac 2863501 ctcttgcagc atttcatcgc caatcgtcat atcggtatta aacatcgcct tgagagtgcc 2863561 gtttttgatc ataaactggc gtttcagcac catttcccct tctatcgttt caccgggcac 2863621 ctcgtactcc gcttttcctg gggaataatt gtagtacaaa cttgatatcg gcgccctcca 2863681 gtcatagatc agaaagtgtt cctccttctc atccaaacag gaagctaaac cgatataaat 2863741 tcgctctgcc tgctcctcgc cgttttcaat aaaatcaatc cggccgaaat aaggcgattt 2863801 tttcaattga tgaattcgtt tgagctgctg atccatgcgc cgatgattgt gttcccgatc 2863861 agacagcagc tctgcctgct gcttaatgct agccatcgtt tcaatcgctt catgggcatc 2863921 atcaaaatta accttaacat cctcccaaaa gctttttctt aatccgatga tatcatgctt 2863981 caacccgccc gcagacgttt ccagaaaccg ctcttttttt tcgagctcct tcagcacctc 2864041 atctattctc gactgctctt ccttccattc cttatcctgc tgattcatga acggcacctc 2864101 cagaaaatag ttgacaaaca tagatgaaat actgtaaaat ataattggat acatatatta 2864161 aatatatgat gcaaactggc aaatacaatt tataatagca cattcaccca ataccaatca 2864221 aggtttgggt tatttatatt atgcagaaaa aaaccgattt cacttcgaaa tcggtttttt 2864281 tgctattaat tatctaagcg aaaagaacgg tttggcagct tccaattaaa catataggaa 2864341 caaacccggc aaacaacgag cacgaaaaac agaacgtata agccgaacga gttccccagc 2864401 cagcccaagc cgacgattaa accgccgagc gccgcccata ccgcatagat ttccgctttc 2864461 agcacaagcg gtttgcgccc ggcaagaagg tcgcggatga tcccgccccc gcttcccgtc 2864521 agcaccgcag ccacgatcac ggcactaagc ggatggccca ttttgacggc atacagtgcg 2864581 ccttggatag caaaggcagc gaggccgatc gcatctgata aattgcccca cttattccaa 2864641 tgcttcagca gcagcttcgg aaacagaaac acaattgtaa tagataaaag cgcgatttga 2864701 aagtacgctc cctgctccca tagcgctgac accggaacac cgatcagcaa attgcggatc 2864761 gctcctcctc caaaagctgt gacaatccct aatatataaa ctcctaaaat atcatattcc 2864821 tcttccatcg caacaattgc gccgctgact gcaaacgcaa tgatgccaat cacactaagc 2864881 agctcccaag ccattctgat gactcccttt tatgtttgtt aaattttctg acgacctcta 2864941 gattttataa tcgctccagc gtaaaatcaa taacattttc atgagaaaaa aagataaatt 2865001 tagagggaat acggctattg ctgatggaca tgagtttgcg aaattaaaaa agcgcccggc 2865061 atacgcgggc gctttttttg ttattcagat ttttcgcctt tcagcaggca cataaaaatg 2865121 ataatcagga taaaagcaat cagggccagg aatggaatcg taataaaacc aaaccagtta 2865181 atatattggc ccgagcacgg cacgccgctg acacatggct taatgccgct aaagccgggc 2865241 actttttgct ctaagtaatg catgatcgaa atgaatgccc caataatcgc catcgggagc 2865301 acatattttt tcactcgtgt gtccccttga aaggtggcga tgcctaaaat caggacgagc 2865361 ggatacatga ggatacgctg gtaccagcac agttcacatg gaataaactt tctgatttca 2865421 ctgaaataca ggctgcccag catagcgata agagccacaa cccaggaagc atataaaaat 2865481 acgattctat ttttcatatt gttacttccc tttcagctct ttttctattg tctctttgat 2865541 ttcatcataa tccgcaaaat ttttgatcac tttatcattg acgtaaatcg tcggtgttgc 2865601 ctgtatgttc attttttgat taaggtcaga atccttttcc acttgagaag cgaatgtttc 2865661 cttatcaaga ttttccttga gcgtctcagg ttttatcttt gtggtgcttt ttgcaagatc 2865721 accaaggagg cctggggtta cccattcctg ttccgtatcc ggctgttttt cgaacagctt 2865781 ttcatggaaa tcccagaaag agtcagggtc ttccttccat acttcttcag atgcaagagc 2865841 cgctaacctt gaaccttttc catggaacat gacgttcacg aaagaaaatt tcacatcgcc 2865901 cttatcaata aagtcttttt gtatttttgg aaagatgtca ctgttaaaca ccttgcaaga 2865961 cggacatttg taatctccga attctactac agttaccggt gcatcgtcct tgccaagcac 2866021 aggctgccct ttgatagacg gctgtccgga caccgcatca ttgccttgtt ccgttttgtt 2866081 attaatgatg acaatggctg ctagcaatac aacaaccaca accgtaagga tgaccgcgaa 2866141 tttcgcagaa gactgctgtt tctttttcac tccgacacct catcgtttta aaattaaaaa 2866201 agaagcggat cgcaattgac ccacttcttt attttaacaa gacaagcgct gataagaaaa 2866261 ccccgaaaaa atgaattctc tccgacaatt tatttgtttt tgagacgcat gacgcgcatg 2866321 gcgttcgcca cagcaagcag tgtaacgccg acatctgaga aaaccgcttc ccacatggtc 2866381 gcaattccaa atgcaccaag aatgagaaag atcgctttca cacctaaagc aaagccgatg 2866441 ttttgccaca cgattcgccg tgtccgtttc gcaatccgaa tcgcttctgc tatttttgac 2866501 ggctgatctg tcatcagcac gatgtctgcg gcttctaccg cggcgtctga gccaaggcct 2866561 cccatcgcaa cccctatatc tgcgcgtgca agcaccggcg tatcattgat gccgtcaccg 2866621 acaaaaatga gtttttcact aggcaaaagc ttagcttcta atgcttcgac ctgcgcgact 2866681 ttatcttgcg gcagcagctc tgcatatacc tcaccaatcc caagctgttt tccgacggct 2866741 tctcccgttt gtttcgaatc acccgtcagc atagctgtct gtttgatccc aagcgacttc 2866801 agatcagcaa ccgcctgtgc tgcgtcttcc tttatctcat ccgctatgat gattgctccg 2866861 gcatagcgtt gatctacagc aacgtgtacg attgttccag cattttcatc cgggacatcc 2866921 tcaatttgtt ctctttccat gagcttttta ttcccagcaa ggatctcagt tccatttacc 2866981 tttgcaaaaa tgccgtgacc ggagatttct tcgtatgact caatctcatc ggaggaaagc 2867041 attttcccgt aagctttacg cacagattca gcaatcggat gctgtgaatg aagctcagcg 2867101 tatgccgccg cttcaagtaa tctatccttt gtaaaacctt ccgcgggttt gatttctgtc 2867161 acttcaaagc tgccttttgt tagtgttccc gttttatcaa acaccgcgta tttgacttga 2867221 ttcaaagctt ctaaataatt gcttcccttt acaagcactc cggcctttga ggccgctccg 2867281 attccaccga agaaaccgag cggaatagag acaacaagcg cacaaggaca agaaatcact 2867341 aaaaagataa gcgcgcggta cacccaatcg gaaagcgcgg cgccagaaag aacaagcggc 2867401 ggaacaaagg ccagcaatac cgcaatgatc accacagcag gtgtataata cttggcaaac 2867461 ttcgtgataa agttttctgt ccgggcttta cggctgctcg cattctgaac caagtctaat 2867521 atttttgata ctgctgattc ctgatagccc tttgtgactt caatatgcag aacgccgttt 2867581 tgattgataa agcctgacat tacatcttgt ccttccgcag cttttctcgg aacggactca 2867641 cctgttaaag cagatgtatc aaccatcgct gacccttgca cgaccttacc gtccaggggt 2867701 atgctttctc ccggattaac cacaatgatg tctcctgtct gaacgtcctc cgacgaaacc 2867761 tgttcgatgc cgttctttgt tttgagattg gcgtaatcag gccgtatgtc cattaacgca 2867821 ctaattgatt ttctggaacg gctgaccgcg gctccttgaa aaagctcacc gatttgataa 2867881 aacagcataa cggcgacccc ctcagggtat tgctgaatca gaaaagcgcc gattgtggca 2867941 agagccatta agaaatgctc atcaaacacc tgaccgcgga tgatgttttt gactgcgcgg 2868001 attataatgt caccgccgat aatcaaataa gcaccgagga aaaggaaaaa ttcaatggtt 2868061 cccgactgaa ccaaatatgc cgctgcgccg agaatgacag ccgccgccat tctgatcagc 2868121 atattgacca ttcgattacg atagccatca tcagctgatt tctttatatg cttttggcga 2868181 accgttacat gcggatcaat tgatttcact tttttctcta ctttattcgt gacccattgc 2868241 tcttctttcc catcggctga gacagttaag gtgcttgccg caaaatttac cgcgcatccg 2868301 ttaatgcctt ttatgccttt gactccattt tcgatttttc gggcacaatt gctgcaatcc 2868361 aaaccgtcca gaacatattc ctgtttcact agtctcacct taccttccga tttagggttc 2868421 cctcttcaaa gcgtatcaat gagtattgta tttattttat atatatgagc atatactcat 2868481 atataagtta cacctattat atgttgtttt ccaagaaagt gtcaatgaaa aacaaaaacc 2868541 ggcatatagc cggtttttca ttttactttt tgcagacgaa gagcattcag aacaacggaa 2868601 acggagctga atgccattgc tgctcctgct atccacggtg ctaaaaatcc aagtgctgcg 2868661 attgggatgc cgaggctgtt atagccaagc gcccagaata agttttgttt aatgtttttc 2868721 attgtcaatc tgctcatgcg gattgcgtcg gcaatgctgt tcagatcgcc gcgaataagt 2868781 gtaatgtctg ctgtttccat ggcaatgtcc gtgccagttc caatcgccat gccgatgtca 2868841 gctgtggcaa gcgccggcgc atcgttaatt ccgtcgccta ccattgctgt ctggcggcct 2868901 tctttttgca agcgggcgat ttccgccgcc ttttgttcag gaagaacttc cgcaatgata 2868961 ttcgcaattc ccgcttcctt cgcgatggct tctgcggttc tgcgattgtc tcctgtcatc 2869021 atgatgacat caagacccaa ctctttcaga cgggcaacag ccttccgcga cgtatcctta 2869081 atcgtatctg caactgctac tagccccgct gcttctccat caatggatac aagcataact 2869141 gttttccctt cggcctctag ctcttccatt tgggcgagaa gagccccatg ctcaacctgt 2869201 tcgctctcca ttaattttct tgtgccgacg agaatgcttt ttcctccggc ttcagccaaa 2869261 atgcctgcgc cgacttttgc ttcaaagcgg gtaagtttcg gtatctcaag ccctttatct 2869321 ttcacgccag caataatcgc ttcgccaagc ggatgctctg atcccgtttc cgctgccgct 2869381 gcaaattgaa gcaaatcttt ttcttcaaaa cggccgaatg gaatggcatc cgtcagacgc 2869441 ggcttcccgt ttgtcacggt tccggtttta tcaagaacaa ttgtatcgag acgatgtgtt 2869501 ttttctaaat gctcgccgcc tttaaataaa atcccgaatt cagcagcgcg tccagatcca 2869561 gccattatgc tcgtcggagt ggcaagaccg agggcgcaag gacaggcaat gacaagaacc 2869621 gcaatgaact tgctgatcgc ttcggcaaaa tcgccaggag ccgcccaaag ataccaaatg 2869681 agaaaagtga gaaccgcaat ccccaataca atgggtacaa aaatgcctga aatctggtca 2869741 gcgagacgct ggatcggcgc ttttgaccct tgtgcttcct caacaatttt gatgatatga 2869801 gaaagcgcag tatcctttcc gacgttgaca gctttaattt tcagaaagcc gtttgcgtta 2869861 acggttgaac ctgtcacgct gtcaccagga tttttgtcaa caggaagact ttctcctgta 2869921 atcatcgatt cgtcaaccgc tgaacggcct tcaaccactt ctccgtcgac aggaattcgt 2869981 tcgccaggtt tgacgtaaac aatgtcatta acaagcactt cgtcgatcgg gatgatttgc 2870041 tcctgtccgt ctcttacaac agtagctgtt ttcgcttgaa gcttcatcag ctttttaatc 2870101 gcatccgagg aacggccttt tgcttttgtt tcaaacaact tgcctaataa aatcagcgtc 2870161 agcaaaatcg cgcttgtttc ataataaagg ccgtctgtat gcccgtgaga gccaatgctt 2870221 tgaaaagtta gataaagact ataagcgtaa gcagccgtcg taccgagggc gaccaataca 2870281 tccatattgg cgcttttatt tctaagcgcc ttatacgcac ccacataaaa cggccagccg 2870341 atcagaaact ggactggtgt cgccagcgca aactgcatcc acggattgag aaatatatcc 2870401 ggtacccaaa tgaatgatgt aaatgtaaaa tggctcacca tcgcccaaag caatggaaat 2870461 gacaggacag ctgaaaaaat cagtctcgcc gtttgcttcc gttcttcttt ctttttagca 2870521 gcagcctcac tgtcctgttc acccttcaac tttagcttat atccaagctt atctaccgct 2870581 tctttcaaat cgctgacaga cgcttctttt ggattgtatt cgaccgtaac tgtttctaaa 2870641 gcgaagttta ctggtgcatt tgcgacgcct tctattttgt taagccgttt ttcaatccga 2870701 ttggcgcaag ccgcacaggt catgccctca atatcgaatt cagctttttc tgtaacgacg 2870761 tgatagccca gcttctctat tttttcctga atcgctgcag tccctgtttc agcaggatcg 2870821 tagattacat ttgatgtttc cgttgccaga ttaacatttg catccgtgac accgggcatc 2870881 cgcttcaggc ctttttcaat tctggcagca catgccgcac aggtcatacc agagacctgc 2870941 atcgcgattt ccttttgttc actcaacata ctcactcctt tatatacacc tggggggtat 2871001 ataaaaatga aagaaatatc gcgcctccct aaaggcgcga taccttgaat cacttggcta 2871061 cgtcatagcc ctgatcttct atcgcatccg caatatcttt gactgatact ttgtcagcat 2871121 caaacgaaac atcgacttta cccgcttcca gattgacatg aacggcactg acgccgtcca 2871181 gttctcctac gcttgtttct actgctttga cgcagtgctg acaagacatt ccttcaactt 2871241 gcaatgtttt ttgttccata tcaattcctc ctgtttattc tttctatttt catcctacca 2871301 tacccccgta gggtattaca ataaaaaacg ctttatgatt ttgtgaactt tttaaatacg 2871361 tccaaaagct cagaaatggc ctgttccccg tctccgcttt tgatggcatc tgctacacaa 2871421 tgatgggcat gatcctcaag caaatgaagc gccacatttt tcattgccgc ctgaacagct 2871481 gaaatttgca caagaatatc tacacaatat ctgtcgtttt ccaccatgtt ttgaatgcct 2871541 ctgacctggc cctcaatccg cttaagccgg tttgtaatct gatccttttc tttcgagctt 2871601 ttatggttta atgttttatg ttcgttatgc ttttccatgc gtacacctct gtttaatgat 2871661 attaattccc attatactga ttgtccaaac ggttgtctaa gcatgccgac gcaaaaaatg 2871721 aatcagttag gttttaccat ttgatcagga gggtatatac ttctgttgat aacgctttta 2871781 aaggggagaa gaaaagtgga tacgatcaag gttggaatat taggatacgg attgtccggt 2871841 tctgtttttc acgggccgct gctggatgtt ctggatgaat atcaaatcag caaaatcatg 2871901 acatcacgga cagaagaagt gaaacgggat tttccagatg ctgaggttgt acatgagctt 2871961 gaagaaatca caaatgaccc tgccattgag cttgtcattg tcaccacccc gagcggcctt 2872021 cattacgagc atactatggc atgcatacag gccggaaaac atgttgtgat ggaaaaacca 2872081 atgacagcaa cggccgaaga gggggaaaca ttaaaaaggg ctgccgatga aaaaggcgta 2872141 ttattaagcg tatatcataa ccgacgctgg gataacgatt ttttaacgat taaaaagctg 2872201 atctctgagg gatcccttga agatatcaat acatatcaag tttcctataa ccgctacaga 2872261 cctgaagttc aagcgcggtg gcgggaaaaa gaaggcactg ccactggtac gctgtatgat 2872321 ctcggctccc acatcataga ccaaaccctg catttgtttg ggatgcctaa agccgtgact 2872381 gcaaacgtga tggcccagcg ggaaaatgcc gaaacggttg actattttca tttaaccctg 2872441 gattatggca agcttcaagc cattctatac ggaggatcaa tcgttccggc aaacggacct 2872501 cgttatcaaa tccatggaaa agattctagc tttatcaaat atggaattga cggacaggaa 2872561 gacgcactca gagcgggaag aaaaccagag gatgacagct ggggtgcgga tgttccggag 2872621 ttttacggaa agcttacaac cattcgtggc tccgacaaaa aaacagaaac gattccatca 2872681 gtaaatggct cctaccttac ttattaccgt aaaatagcgg aaagcatacg agaaggtgct 2872741 gcgctgccag tcactgctga ggaaggtatt aatgtcatcc gcatcattga agccgcgatg 2872801 gaaagcagta aagagaaacg aaccattatg ctggagcact aaaacaaaag cctccccaaa 2872861 taaggggagg ctttttcatt agaatgtttt tcctgcttct ttcgcacgcg caatcgcgtc 2872921 ttctttgatt tgctgtgctt tatcaggctc cgcattatgt ccctctacga aaatgccatc 2872981 gaatgatggt acgccgaaga agttcatcat gatgccgatg tagcggtgcc ccatttccat 2873041 ctcagccgca gggccttctg aatagtagcc gccgcgcgct tggatatgaa ttgctttttt 2873101 atcagttaac aagccgacag gaccttgttc tgtgtatttg aatgattttc ctgcaacagc 2873161 aacagaatcg agatacgctt tcatcactgg cgggaatgag aagttccata aaggagtaac 2873221 aaatacgtac ttatcagctg atgcaaattg atcgctaagc tctcccaaac ggcctacttt 2873281 cgctttttcg ctttcagaaa gctcttcaaa gcctgtacct gactgaagct ttccccatcc 2873341 gctaaataca tctgcgtcaa tgtgcggaat gttttctttg tacaaatcga tatgtacaac 2873401 ttcatcattt ggattcgctt ctttgtaaga ttcgataaat gctttacctg ttgccatact 2873461 gtacgaagtt gcttcgtcat gtggatgagc agtgatatat aatacttttg ccatttttac 2873521 cagccctttc gtttttaaaa atcacacatc aattattatc atacagatgc ataatgatta 2873581 ttctgtctct cttagacttt attatagaga caaagaaatt tactttcaag taaaacatct 2873641 cgaattaaag attatttaac tttcccaaac agcttacttt tcaaaagctg ttctcaagcc 2873701 ggaatacagc gcggacaatt ctttactgat ccgaggataa tgagggacat gcggcacttg 2873761 aatatccgca ggcatccttt tcatgataaa ggattgctca gcctgttcaa aaaacgcccg 2873821 cagctggttg atctcttcat cagaaaacgg agcagacgga cggcggtgag cttgcgccga 2873881 gagcaaatag taccctaagt gctgagcacc ggaaatggca ggccagagcg catccgcatt 2873941 cgcgtgagga aactcgccaa gcgccttgtc atacgcatcc cgaagcctga caagactcac 2874001 ccttaacttg tgttcgtcgg caatttgccc ggttaacagt ttctccataa actgcccttc 2874061 cagccggatg acattccgca caagttctgg cagccgcttg gttgaaaacc gccgccacaa 2874121 aagcattgtt cccaacagcc cgatcacgct gccgacagct acatcagtca gcctcgctat 2874181 cataaaataa ccggcgcccg ccccgccatg catactttct gtgataacaa gcgcatttgc 2874241 ggttaaaaag ggaacagcca gcgcataatt gcggacgatc agcatctcaa gaagacattg 2874301 cagcgctgca atacaaaacg caatataaac accgcccggc ttaaaaaaca ggattgcgcc 2874361 tgccagtata acaccgatca ccgttccggc cgaacgctga atagccctgt gaagcgtaaa 2874421 aacaacagta gtgccaagca tgaccgctgc tgccgaaagc ggaatccaat aggagcgtgc 2874481 aaagccgaat gcgagggcaa acatatcggc ggcaaacaga acaattccgt actttaacgc 2874541 tctaatcaaa actggagact tccagtcaaa ggcatttctc aaaaagtaaa aagaggatgg 2874601 caggcggctt ggttccccgt caagctgctt atcaaaacgt cctgaagcga tatacaaaac 2874661 ctcattgatt tcttcaaaca gcttccgcct aggctcagat tcattttcat taatctgaaa 2874721 cgtattgaaa acccgtgcat tcgcaagcat atctccggtt tggcgaagtg ccttttcaat 2874781 ctgcgcggtc tctctgtccg gcgtttcagc tgaaaaatga ataatggcaa taaatatgtc 2874841 gtcagctttc tcaaggaggc gaaaaaatcg ttcatcatgc cgcgattttt tccgtctgtt 2874901 ccctttccca agaaccgttt ggcgggctgt tctaagcatg agcaccgtct gatgctgtgc 2874961 gttatgaaaa cctggcgttc cgacggctga aagacatgca gccagctgat gatatgtttt 2875021 ttgcagcacc gctccctccg gtccatgttt gttccataac cagccgatta aagcgatacc 2875081 catggcgaaa atgccgccga gaaacgtcag tcccgctctg aacagcgctt gtgaaggatc 2875141 ggccggcagc ccggaactga ctaaaaaggc aaggacaaaa aacatcggcg cagggccttg 2875201 aatgccgagc gcgctaaaaa taaacatcgc cgctgcaccg atcagcccca aaacagccgc 2875261 catcatccaa agcatcccgg acaaaagcgt ccctaaacca aatgagaggg cgatcccaat 2875321 agaaaccaag agcagcttca aggcgcgctt tttgtacgat tcaccgcccg catataaata 2875381 aacaaagcct ccgatacttg caattaatcc gtaatccgtg tgacctgcca atgcaccgac 2875441 cagcacagga aaccctgaag cgaaacctga tccgatagcc tttttccaag gaaatggatt 2875501 tgcatgaatg cgaaaggcat ccttcacgat aggcatgatt ctttgattgt tcgcagcagt 2875561 tttgttcatt tgacaaaatc cttttcaatg aatgtgtaga acttttccag tttcttcgct 2875621 ttagtatgcc caaaaacgcg gttagcttct caattggtgc gcacgataaa aaaacagaga 2875681 cttataccgt ctctgcttca ttacatcagt ttattataaa agcggcacct gtcaggactg 2875741 ttttgtcctt ctgccttcct tcaagagcag gtgaataaaa aataaaggat aaatcaatag 2875801 atacccatta aacagccacc acacaagatc aaagtcactg ctgaatgtcc agaatgatag 2875861 cgcctgcaga cctgaacaac aggtcagcac aagagaaatc agcgccatca gcttccagtc 2875921 agcacgattc acccgctgta ggtacaagct gtacaaccct gtgacagaaa tcaggatatc 2875981 cagcggaaaa aaagaccagt tccaagcgat cataaacgga tggtcatgat gtttaaaagc 2876041 ccagctttcc ggtatgagcg aaaatccggc tgacagccag tacaagataa aaccgatatc 2876101 agtcacgaga aaaaacagct tcatatatct catttgtact gcccgctttt atgtaccggc 2876161 tcagacaccg caacatgctc gatcaggttt aaagacacaa caccggcaat aatcaatcca 2876221 attgaaatga ctttcatgac actcacatgt tcttgaaaaa acaaaaaacc aacgactgta 2876281 atcaagacaa ttcccatccc tgaccataca gcataagcaa ctgatacatc aatggattta 2876341 agcgtaagcg tcagaaagaa aagactccct ccataaaaga aaatcaacag caaactggga 2876401 ataagctttg taaaaccaga cgatagcttc atgctgacag ttcccgcaac ctcaaacaaa 2876461 atcgccaagc atagaaacac ccaattcatg tggcatcagc ctcctcatca gctgttatac 2876521 cgttaaacaa aacatctaca attgattcaa gtacctctcc tgtcgtgaac tgatgtttca 2876581 gcggatattc agggtcatac acttgattga tgctccctat atacatgtga acaaacaggt 2876641 ccggattgat gtttctgatt ctcttttgct gtttgcactc atttaataat gctaggacaa 2876701 tcgcccattc ttccttaata aacgcgtcta atgtaagcca cgcatcgtaa tggtatttct 2876761 ttagttcatt taataatccc atgttcagca gttccatccc ctgcggaagg ctgatcagca 2876821 tttgtttcac cttttcgagc acatttaaac tttcattttc atagatgtct ctttctattt 2876881 gcttcatttc agctataaat tgttcgacaa ccgcctcaac aagctgatct ttagatgaat 2876941 aatatgcata gagcgtccgc ttgctcgttc ccagcgctgc cgccaaatca ttcatcgtaa 2877001 atgaaaatcc tttctgcttg atcagccgga aggtttccgc cagaattctt ttatccatat 2877061 taatcccccg ctttcggtac caagaaaact atttcggtac caatattata cggcagaaat 2877121 ttatggaaat caacaatata taaaaaaacc tctcctattg ggagaggttt aaaagacact 2877181 gcggaccaaa ccgccgtccg cccgaagtgc cgcgccattg atcgcagagg aaagcggact 2877241 gcttaaaaat gtaacgaagt gggcgatttc ttccggacgg atcagtcttt gaataataga 2877301 tgtcggccgg ttttctttca taaaacgtgc ctcagcttct tgaacagtca ggttttcacc 2877361 aggatacagc gagttcagca tggtttccac accctctgtt aaggtagagc ccggcatgac 2877421 ggtgttgact gtgacattcg tgccggttgc cagctccgcc aaactgcggg aaatggacag 2877481 ctgcatcgtt tttgtcgcac tgtaatgggc catttcctgt gacggcataa tcgccgcttc 2877541 actggcaatg aaaatcacac gcccttcttt tttctctatc atgttatgca aatacctgcg 2877601 tgtcagcctt acaccgctca taatattcac ttcaaaaaaa cgaaaccatt catcgtcggg 2877661 aatatcaaag tactccgccg gttcaaaaat ccctaaattg ttgaccaaaa tatcaacctc 2877721 tggatatgcc tgaaacagct cattgcagcc ttcttctgtt cccaaatcaa atgcagccgg 2877781 ataaagaacc gcttcagcat gttgtgtttt cagttcatct atcgtttgat tcactttctc 2877841 ttcccggcgt ccgttaatga tcactgccgc accttcttca gctaacgaag aggcaatagc 2877901 ttttccgatc cctgatgtcg aaccggtcac cagtgcggtt tttccttgta aattcagctt 2877961 cattattcat ccctccgttt ttgattcctc ttatttattg acagaaatct gattggtgaa 2878021 acatctgctc tgcaatcagt atgaaacagc tgggattgaa atggaagtac gcactttttg 2878081 gtgcctgtgg tttggagaaa aaataaagca gaacctctta agaggttctg ctttattgtc 2878141 agtatgtatg gagacggtgg gagtcgaacc cacgtccaga aacatcgatt acttaagcgt 2878201 ctacgagcgt agcctgcata tttatggttt cactcatctt cttgcctgcg ggcgggcctt 2878261 ccgagagcta gtctgttcat ctcttcttac gttctcagac gggaacgcaa gcgtagccta 2878321 cttggatgtg ctcttcacag acacataggc aatgtcagga agagctcgct gcgcttatta 2878381 ggcagctaat gctacgtttt ggttaaaact gttagttttg ccagttatat ttaagtgcgt 2878441 gtttacgaga tcgcctctcg gctcgcagct caagctcgat ccatccctgt cgaatccgta 2878501 acgtcccctt ggtataaggg aaatacggga gaaaatatca agctctcact caaactggct 2878561 atagtcttat tataacatga tcacggctct tttcaattgt caaatccttc aaatgaatgg 2878621 cgtcgtgatc tgatcgtgaa cacagtatag cacaggcctg attttcgaat caagcactat 2878681 gcctttagaa gcctttttga ctgtctctga acgctctttc gatttcccgc ttcgcgtcct 2878741 tgcgcttcag atcttcccgt ttgtcatagt tcttcttccc ttttccaagg ccgagaagca 2878801 ctttggcaaa gccgtttttt aaatacagct tcagcggaac gagagaatag cctttttcct 2878861 ttgttaaccc gatcagctta ttaatctcct tgcggtgcat taacagcttt cttgtccgga 2878921 gcggatcgtg gttatagcgg tttccctgct catatgggct gacgtgcata ttgtggagaa 2878981 acacttctcc ccgttcgatt ttggcgaagg aatccttaag gtttacgcgg ccggcgcgaa 2879041 tcgatttgat ttcggttcct tgcagaacga tgcctgtttc ataggtttct tctataaaat 2879101 aatcgtggtt ggctttctta ttttgagata atacttttcc tgaccctttt ggcatgccag 2879161 aacctcctct ctctaaggaa aaactgtcca ccttttgcga tacgctctat tttaccaaat 2879221 gtcacgtacc gctacaatga aaagctgttt ccgaaagaaa gcaaatagag cgctgcggcc 2879281 ctatttgctg gttgagctgc tatttcttct ttttccgttt ctgtttcgga gcattctgga 2879341 agccgcgttt tttctttttc ttcttcggct tagtgaacca ctcccctttt tcctcagacg 2879401 gagctggaga aacaggtgta ttggtgcttt gaacacgttt tctggcaggc tttccgcgtt 2879461 ttctgctccg gctgctgtcc aattctctcg gacgccgcgg agtgcctttc atgccgacaa 2879521 tttcaaagtc gatattgcgc tcatctttat tgacatcgac aaccttgact gtgatttcat 2879581 ccccgatgcg gaagacgttg cctgtccgct cgccaatcat tgcgaaatgc tgttcgtcaa 2879641 agcggtagta gtcatctgtc ataaagctga catggacgag tccttcaatt gtattcggca 2879701 gctcgacgaa cattccgaag tttgtcacag agctgatcat gccgtcaaac tcttcaccga 2879761 ttttatcaag catgtattcc gcttttttca gatcatccgt ctcacgctcg gcgtcaactg 2879821 cacggcgctc catagatgat gtatgttcgg cgatatccgg caggcgttca gcccactttt 2879881 cctgtgtcgc ttcatcgacc ttgccgttga tcaaatacgt tcggatcaga cggtgaacga 2879941 ttaagtccgg gtaacggcgg atcggtgatg tgaaatgcgt atagaattcc gttgacagac 2880001 cgaagtgccc caagctttgc gggtcgtatt tcgcctgttt catcgaacgg agcataacag 2880061 tagatataac cgtttcctct ggtctgtcac gcacagcgtc cagaatgctt tgcagcgcgc 2880121 gcggatgaat attccccgcc gttcctttca ccacatagcc aaatgtcgtc acaaattcta 2880181 aaaacttttg cagcttttca gcattcggct cttcgtgaat ccggtatata aacgggacat 2880241 tcatccaatg gaaatgctcc gcaactgttt cgtttgctac aagcataaat tcttcaatca 2880301 gcttctcggc gacagagcgt tctctgatca caacgtcttt aaccgctcct tcgtcatcaa 2880361 caagcacctt tgcttctttg aaatcaaagt caacggcgcc gcggtccatc cgcttatcgc 2880421 gcagaatttg agccagacgc tccatgtctt tgaacatcgg aacaagaggc tcgtattttt 2880481 gtttcagctc ttcatcatca tcaacaagaa ttttattcac atctgaatat gtcattcttt 2880541 ccgttgtttt gatgacactt tggaagatct cgtgctctgt cacctgtccc tgactgttaa 2880601 ttgtcatttc acaagaaagc gtcaggcggt caacctttgg atttaaggag cagatgccgt 2880661 ttgacaatct gtgcggaatc atcgggatga cacggtcaac cagatacaca cttgtccctc 2880721 tttcaagcgc ttctttgtca atcggcgagt tttcggttac gtaatggctg acatcagcta 2880781 tgtgaacgcc aagcttgtag cttccatcat caagcttcgt cacggtaact gcatcatcca 2880841 aatccttcgc atccgcacca tcaatggtga caatcacctg gtcacggaga tcacggcggt 2880901 ctttcagatc tttttcatca atcgtgtcag gcgtacttga tgcctgttcc atcgcgtcag 2880961 ctggaaattc tcccggcagg ccgtgcttat gaatgaccga taaaatatca atgcccgggt 2881021 cgtttttgtg gccgagaatg gtttcaacct caccctctgc gttcatgcgg ccttcaggat 2881081 agctcgtcag cttgacaaca accttatgcc cttccgcagc tccatttttc ccatttttcg 2881141 gaatgaagat gtcactcgtg atttttttgt cgtccggaat gacaaagccg aagtttctcg 2881201 tttctgtata cgtgccgaca acccgctgaa tcgctctttc taaaatccgt atgacggttc 2881261 cttcctgcct ggagccgctt gattgtgagt tcagacgcac catgacgata tcgccgttca 2881321 ttgccgtatt tagctcatta ggcggaataa acacatcact taacgacgta tcctcaggca 2881381 gcaaaaaggc gaatcctttc gcatgggctg aaatctttcc ttttattaaa ttcatcttct 2881441 ccggaatgcc gtagcggtcg cttctcgtcc gtacgataag ccctttttct tccaaggcga 2881501 ctaacgcttt gacgagctct ttaaactcct cggcttccgt aatatttaac atctcctcaa 2881561 gttcctgaac ggtcagaggt ttgtacgcct cttccttcat aaacgagaga agcttttcca 2881621 taaatgcttc tttttccatt atccgacctc ctgttgatta ccaatcgagc ttctctaaaa 2881681 attcatacac atcctgatgg acgaggtcac gttctttgtc gagtgtaatg acatgccctg 2881741 attcctcgta ccatttcagc tgtttatcat cagtttccac ttcgttgtaa ataatattgg 2881801 cgctttcggt attaatcatg tggtcatgac gggcctgcac cacaaatgtc ggtgaataaa 2881861 tcatatcgac attattccgc acatcagcaa ttaagtcttg cagcgccttg agggtattca 2881921 tcggcgtttt ttcgaattct ttcatttcct cttcaatttg ctccgggctt ttcccctcaa 2881981 actttttgta attgcgagcg tatgaaagaa cgccttgata catgacctct tcactcttaa 2882041 tatgcatcgg tgcgcacatt gggacaattc cctttatggg tacagtgtaa cccaatttca 2882101 gcgaaaaaac cccgccaagc gacagtccgc aggcagcaat gctctcataa ccttcagatt 2882161 ttaaatattc atagccatcc attacgtttt tccaccagtc ttcgggcccc gtatgtacaa 2882221 gttcttcagg cgggacgcca tgtccttcat attgaggcgc gtggcacgta tagccgcgtt 2882281 cattcaaata tcgtcccagc atccttacat ccgctgtatt tcctgtaaag ccatgcagca 2882341 aaagcaccgc tttgtctccg cctttaaatg taaatggttt tggtgtcaca actttcatgc 2882401 tcatgtctcc ctttctatct gcacgatcat tttagttttc cacagtttaa tcagaaaaaa 2882461 acgttttgaa tatcatccag aaacgtgaaa aaggcctgac ttcacatcag accttataca 2882521 aacattgccc tataggatat aagcaagcgc aatcgttaac acgaaaaaca agactgccag 2882581 cactaccgta atgcggtgca aaattaaatc aagacctctt gctttttgtt tcccgaagag 2882641 ctgctccgct ccgcctgaaa tcgcaccaga taatccggca cttttactgg attgaagcaa 2882701 aacgacaata ataagtgcaa tgctgacgat aaccaataag gtaatcaaaa ctgcgtgcat 2882761 cccatacacc tccagactca ctggctacat tacttctatt ttacatgaaa agggttggca 2882821 tgtcacgctg tatcagacgc caaaaggccg gataagacgt tttatcttgg ttaccctatt 2882881 catatgaaaa ggtcaaagga gaaaagcgat gccgcttatc agcatagaca gcaggaaaca 2882941 tcttttttat gaagaatatg gacagggaat ccctatcatt tttatccacc cgccgggcat 2883001 gggacgaaag gttttttatt atcagcgcct tctatccaag catttcaggg tgatttttcc 2883061 ggatttaagt ggccacggtg atagtgatca catcgatcag ccagcgtcta tttcctatta 2883121 cgcaaacgag atcgcgcaat tcatggacgc tttgcacatt gataaagctg tgttattcgg 2883181 gtattctgcc ggaggcttaa tcgcgcagca tatcggcttc acccgcccgg acaaagtgtc 2883241 acaccttatt ctgtccggcg cctaccccgc tgttcataac gtaatcggcc agaagctgca 2883301 caaactggga atgtatctgc ttgaaaaaaa ccccggtttg ctcatgaaaa tcctcgctgg 2883361 cagccacaca aaagacagac agcttcgcag catattaaca gaccatatga aaaaagcaga 2883421 ccaggcccat tggcatcagt attatctgga ttcgcttggc tacaactgca ttgaacagct 2883481 gccccgccta gaaatgccaa tgctgtttat gtatggcggc ctgcgggact ggacctttac 2883541 aaacgcaggc tattaccgaa gatcgtgcag acatgccgaa tttttcagat tggaatatca 2883601 gggacatcaa ttgccgacaa aacaatggaa aacgtgcaat gagctggtga cagggtttgt 2883661 gctgacacat cattcatagg aatagaaaac gcttggcttc cttgcgtttt ttgttacttt 2883721 attgactttt gtcaacgaaa tcatagtaaa aaagatcctc aaatttcaaa ttaaaatagt 2883781 gaagcatttt accaatcaca agctgccccg gccttctttc tccattcagc acgcggctca 2883841 gtgtggcggg tgagactccg atttccagcg caagctgatt aagggaataa tcgttattaa 2883901 ccatatactg caagacataa tcacgtctaa tctgtatctt ttctactggc actttcctca 2883961 ccttccattc ctgaaaaact tttttctata cttttacatt acggcttatg ttaacttttg 2884021 tcaatacatt tccagtctac ctattccctt tagtcaataa acatactaaa atatgagtaa 2884081 cagtgaggga cggggtgaga tatatggaaa gctttggcga acaattacgg gcattgcgtg 2884141 aagagagaaa gttaacagtc aaccagctgg cgacttattc aggcgtaagc gcggccggca 2884201 tctccagaat cgaaaacgga aaacggggcg ttcccaaacc tgccaccatc aaaaaactgg 2884261 cagaggcctt aaaaattcct tatgaggggc ttatgtacaa ggctggttac atcgaagaag 2884321 tgcatgaagc cagggcccct tatgaaacga agtgcaagct gcttgaaaaa gcggaggcct 2884381 atgacctgaa aaaccttgcg cttcttgaga acgaaaagtg gcaatatctc aataaagaag 2884441 atttgctcat gctggatcat tatttttcgt ttatttcaga tgaagcgaaa aaacggtctg 2884501 ctgatgactg actcttgata gaaatgtgag gcgatagacc atgtcaccgt tcggacagca 2884561 attacgggag ctgcgccgcg cccgcaaact gacagtgaat cagcttgcgg tgtactcagg 2884621 catcagctcg gccaccattt caaaaattga aaacggcaaa cgcgggacgc caaaacccgc 2884681 cacgattaaa aaactggcag ccgtcctgaa agtgccgtac gaaaacctaa tggccgccgc 2884741 aggccatatt caggcctttc ctgaagaaat ccgcgaagca tctgaaggct atcaatccgt 2884801 ttatgaaatt taccagacgg ctgtcacacg cggagcggag cacctcccga ttttcaatag 2884861 tcaaaaatgg gaacatctct caaagcagga tattgaaaat ctcagcaaat acttcgattt 2884921 tttgtcttca gaagcaaaaa aacgcgcctc ttcctcataa tcccctgttt ctctttctat 2884981 attttatcaa tcacgcttgc atgccctccc tcgttatttg cgttataata gtgacagacg 2885041 aggtgaaaag tatgaaccaa tcagaaatgt gtcctagatt tgaaaaagca gtcgacatct 2885101 taagtaaacg ctgggtcgct ttaatcgtat ttcagctctt gaacgggtcg cagcgattta 2885161 gcgaaattga agcagcactt ccaaatctaa gcggcagagt tctgtcagaa cggctgaaag 2885221 aacttgagct tgaaggagta gtgaagcggg atgtcatccc tgaaactccg gttcgcatcg 2885281 aatattcatt gactgataaa ggaaaggcac tagcacccat attaggtgag atttctaaat 2885341 gggcgactga atggattgac ccttcctttc ttgactaatt gctaaaatgg ttctgatctc 2885401 aaagacgaga aaagaaccgt tttttatttt ccaggtgaaa aaaagatatc tcagccgata 2885461 tatagtacat ccacacatta cgtttttaaa ggagaccact atatgcgact gacgatttcc 2885521 cgcaaattca gcctggtatt tttgacactg atcctgatca atttacttgt aggcggaata 2885581 ggcgttctta atatgcagca tatcattcaa aaaacagatg aaatcaacac aaaatggatt 2885641 gacggcatca aaggaatcac ttcaattaat tatgtaaccg agcacctgtc ttctaaagaa 2885701 aaggactttc tgatttatac agacaaaagt aaaatggata cacttgatca agaaatgaat 2885761 caaatcatgg aagacattaa ccaaaagctc gataactacg aaaaaacgat ctccactgat 2885821 aaagagcaga aactgttcga gcagcttcaa actaaagtga atacctatat ggatattcat 2885881 gcgcaaatta tcgaaagcgg ccgcacgaat gacatggaca aagcaagagg tttattggtt 2885941 cagactgagg ccagctttga ggatatgaaa aaaacaatca ctcagcttgt tgacttaaat 2886001 caagaaggca gcaacacagc ggtaaaagaa acgaaggccg tctatcataa agggctcatt 2886061 tacactgctt tgcttgtggc agcatcaatc ctcatcagca ttttcatctg gctttatatc 2886121 acgcgaaaca ttgtaaagcc tatcattcgc atgaaggaat ctgccaatca tattgccgaa 2886181 ggcgatttgt cgaacgatat ggaggccctc aactcaaaag acgagctggg tgatctgaat 2886241 gaagcgctgc aaaaaatggt agggaatctg agagatattg tcggatattc taaagacata 2886301 tcaagccggg ttctttcttc ttcacaggtg cttgcaaccg caacgaatga aacaagatcc 2886361 ggcagcaaac atattaccga gacgatgaac gaaatggctg agggctctga acagcaggcc 2886421 caagacgcgg tgacgattgc cgaatcgatg aatgagttta ccgaaagcat tgataaagcc 2886481 tataatcacg gcatcacaat cagcgatacg tctcaaaacg ttctcgaact cgcggtaagc 2886541 gggaacgaaa atatggctac gtcattacag caaatgaaaa ccatccatca tattgttgaa 2886601 gaagccgtgc ataaagtgag atcactggaa cagcattctc aggatattaa caagctcgtt 2886661 caggtcatca acgggattgc cgagcagacg aatttgctgt cccttaacgc cgcgattgaa 2886721 gctgcccgcg ctggagaaag cggcaaaggc ttcgccgttg tggcagagga ggtcagaaag 2886781 ctggctgacg gcgtttctga ttccgtgcag gacattaccc ggattgtaaa cgggacacag 2886841 caggagatcc acactgtcat tacgtacttg gaaagcagct ttacagaagt cgaaaaagga 2886901 acggaaaacc tgacagacac cggacaggct atgcagcata tcaaacaatc cgtcacccat 2886961 gttgcagaca gcattaagga agtaacggat ggcttgaagc agttaacaaa ccaatcgatt 2887021 accatcaatc aatcgattga aaatatcgct tctgtatccg aagagtctgc cgccggcatt 2887081 gaagaaacat tttcaattac cgagcaatcc gcccattcga tggatcaagt gcttctaaat 2887141 gctgaagagc ttgagcagct ggccaatgag cttaatgaga agatgggtca gtttacgatt 2887201 taaagagaaa aaagaggctg gactccagcc tctttttcta ttctatgcag ctgattgaac 2887261 atgtttcgcc ccggttcttt ttttcttcac cggacttaat gcccgctcca gccaagccat 2887321 gagcaaatcc gcccctaccg ccatcaccgc agttggtatc gctccggcta gaataatcgc 2887381 agttccgttt gttgcgtttg agccgcgtac gatcatgtcc ccaaggcctc cggcaccgac 2887441 aaatgtgccg atcgctgtaa ttccgatggc aatgacgaga gccgtgcgaa ggcccgccat 2887501 aatgacagaa agtgcgagcg ggagctcaac cattctgagc acttggaatt tcgtcatgcc 2887561 cattgctttt ccagattcta agtaggcatg ttcaatactg ataatgcctg tgtacgtgtt 2887621 tcgaataatc ggcagcaggg aatacagaaa taatgataga atcacggtat ttgcgccgag 2887681 ccccataaca agcattaaga cggccagcat agcgagcgcc gggattgttt gaataacgtt 2887741 tgttacggca aacacccagg ctgacaaacg gcgaaaatgc gcgatgagga ttccggccgg 2887801 aaccccgacg acagcggcaa ataaaacgcc gtaagccgac atgagaaagt ggcggccgaa 2887861 ttcatccatg acgtaactgc cattctgcgc gtaatacgtc attaactgtt caagcacgtt 2887921 cattgacctc ttcccccttt cacgattcga aatagcgatg tttttctaaa tattccttgg 2887981 caacgacaga cggttctttg agattgccgt cgacttcata gttaagctcc tgcatcgtgg 2888041 ctgtgtcgat ttttccgagc attttcttga tgatgccttc aagttcagga tgttctttga 2888101 gcaccttttc cggaacaacc ggagagcagt cgtacggcgg gaaaaattgt ttatcatcct 2888161 ttagcatttt gagaccatag gacttgattc ttccatcggt tgaatacgca agcacaatgt 2888221 ccatttttcc gcttttcacc gcgtcgtaca caaggccgat ctgcatcgga tacgtgccgc 2888281 cgaatgtcat gccgtaggtt ttcgtaaaat cctgatagcc gtttcctttg agcttcatcc 2888341 aatagttatc aacgcccagc tttaattgcg gcgcccattt tttaacgtct gatacggtct 2888401 ctaaatggta ttggtcggcc agctccttgc tgactgtaaa ggcatatgta ttatcaaacc 2888461 cgtaggagtc ataccacttt aaatcatatc tttttttaaa ctcccgctga gtaagcgcca 2888521 gcgctttgtc cggatctttt tcaggttcca ttctcaacgt gcctgtcagc gcgtctcccg 2888581 tatatcttgt ggccgcaatg tcgatttccc cgttcattaa agcctgctgc tgcaccgcgt 2888641 tggagccaag atttttaatc gttgttgttt tgagatcagt atggtgttcg atcaactggc 2888701 caagcatgct ggcgatgatt tctgattcgc tcatgctttg cgcgccgatt ttaatggtct 2888761 ggtctgcagc agcgctgaga ccaggaagcg aacagccgct cagcgtcagc gttgccgcaa 2888821 gtgctaaacc tatcattaat ttgagatatt ttcttttcat gagccgcctc cttatgacaa 2888881 ttccttcaat ctctgcatgc cggcaggtgt cagttttcgt tcagcaactg ccagcacata 2888941 atcaatcaca attgccaata tcgtgacagg taccgcgccc ccgatgatat attccggctg 2889001 atataaattc agtccgataa aaatgtaatc acccaatccg ccgcctccga taaaggaagc 2889061 aagcgtggcc cagccgatta agtaaatcgt cgatgttctg attcccgcca tgatcactgg 2889121 tgcggcaagc ggcagctcca ccaagcggac ttgttcagcc ggcgtcattc ctattccttt 2889181 accagactcg agcagatttt tgttgacgcc gcgaatgccg gtatacgtgt tgcgaagaat 2889241 cggcaatacg gaatagaaaa acaaagccac aatggccgga accttcccta caccaaggag 2889301 cgggataaaa aaagcgagga tggccagact cggcagcgtc tgaatgatat tgacaatgcc 2889361 gataatggtg ccggctcctt ttttcattct ggtaagcaca accccgaggg ggacggcaac 2889421 cagcacacct aagatcacag caatgagcga tatcgtaata tgctcgtatg ttttataaag 2889481 aagctctccc ccattggttt gcaaaaattg aacaatatga tgcatgactt atcgcccctc 2889541 cctatgacaa tgctgcgagc tgcttttctt ctccccagag ggagtcatac acgatgtcga 2889601 ccagacttgc cctcgtcaca attccgatca ggcgtcggtc ttcatccaca acgggaacat 2889661 atttgacacc ccgttttaaa attttgcgga ccgtgtcgcg cagcagtgtg ccgcccagta 2889721 ctgtgtatat atcttcatgt aaaacttcac tgacgagatt ggcctttttc cggcattgat 2889781 caatgatttc aacatcgaca tagccttgca gaacgcgctc gtcattgacg accagcaatg 2889841 aatcgacccg ttcctgcctc atcagctgaa tggcctcaga aagcgtttta tccgcggtga 2889901 tcgttacagg ctgtgtgttc ataatctggt caacccgttc aacatccggg ctggatgact 2889961 gaatcagccg ctccttgccg ataaattcct caacaaattc gtctgccgga tttcttaaaa 2890021 tgtcatcggg cgttccaact tgaacgattt ctcccgcttt taaaatcaca atccggtctg 2890081 ccagcttaat cgcttcatcc atatcgtggg taacaaatac gatggtttta tgtaaggttt 2890141 tttgcagttt tttaaattct tcctggaggg aatccctcgt aatcgggtcg agtgccccaa 2890201 acggttcatc cattaagata agcggcggct ccgcggcaag tgcccgtaat acaccaattc 2890261 gctgctgctg ccccccgctt aattcatgag ggtaacggtc tacatattct ggccccatat 2890321 cgaccaattt taaaagctca cgcgcccgct ctttccgctg ctgctccggc catttcagca 2890381 gttttgggac gagtgagata ttctgctgaa tggtcatatg gggaaacagg ccgatctgct 2890441 gaatcacata gccaattttg cgcctgagct ctacaggatc ctggtccatg atgttttcgc 2890501 cgtcaatgaa aatcttcccg gcggaaggct caattaatcg gttaatcatt ttcattgttg 2890561 tcgtttttcc gcagccgctc ggcccgataa agcagataaa ttcgcctttt gcaatcttaa 2890621 gatttacgtt gttcacggct tttttgccgc ccttgtatgt tttcgagaca ttttctaatg 2890681 tcagcaaaca tcgcacctcc aaaattaagt ttattcaatt tgttcagttt aaatttaatt 2890741 tttcagacaa ttgaatgctt cccattatag aataaagttt ataaaataaa aagtttacaa 2890801 tttgttcata ttatttataa agtatgtgta aacgctgatt tacccgcatt gacgtgtgtt 2890861 gatctcctta ttgctccaat ttcctgccaa attctctttt gacagcattt tcgccgtatc 2890921 aaaaatgtgg tatattgaca tcggaattgt tagctgaaag gatgaaaccg ttggagaaag 2890981 atccgttaac gatcattgaa caagccgagg accattttat agaaagaatc gcggaaaaca 2891041 tgcatgcatt tggaatgccc tctaccgtcg gacgagtgct gggcattatt tatatgaatc 2891101 gaaaaccgat gacgcttacg gaattatctg aggccaccgg catgagtaaa acacgtatga 2891161 gccaggtagt gcgggaaatg cttgatgcca acattgccga gaaggtattc gaaaaaggcg 2891221 tgcgaaaaga tttatatgag gttgagcagg actactatca aacatttatc acgctgtttt 2891281 cagccacctg gagcaaagtc gtcagcaaaa acaaaatgat gcataaaaaa ctcaatcggg 2891341 agctgcttag cgtgttggat gaagagctta ctcctgaagc ggaagaaaaa gtgaatgagc 2891401 tgctgaagga attaaaggaa tggctcgatt attataattg gctcagccgt ttgattgagt 2891461 tttttgagag cgaagacatt tttaaatatg tgccgaagcc gtaaaaagtt cccaaattca 2891521 attctgggaa cttttttaag tccaatccaa atggttgaat atcaaacttc gagctcccaa 2891581 cgctggaaaa tatgtttaac agatactaac acatgttgtt tatttaaaaa aaccacctct 2891641 gttgtattta aatagaggtg gtttttctat cagctataat aaaatttcct tttttctttt 2891701 taatcgggct taatgctcgt tcaagccagc ccatgaccaa atcggcaatc accgccatca 2891761 gagctgtggg gatcgctccc gctaatataa tcgcggttcc gtttgtggcg tttgatcctc 2891821 tgacgatgat gtccccgaga ccgccagcac cgacaaatgt cccgatggcc gtaatgccga 2891881 tcgcaatgac aagcgcggtg cgcaggccgg ccattatgac agaaagcgca agcggaagct 2891941 cgaccatccg cagcacttga aattttgtca tccccattgc ttttcccgat tcaagatagg 2892001 cgtgctcaat actgataatc cctgtatacg tatttctgat aatcggcaga agagaataca 2892061 gaaataatga caatatcacc gtattagcgc ccagccccat gacaagcatc agcacggcga 2892121 gcatggcgag agccgggatg gtctgaatga cattcgtgac cgcaaaaacc catccgctta 2892181 atcttctgta tctggctatc aggatgccga gcggaattcc aacaatggcg gcaaataaaa 2892241 cgccatacac cgacatcaga aaatggcggt aaaattcctg cagcacgtaa ccgccgtttt 2892301 gcgaatagta tgtgccaagc tgctgtagta cttccatatg atccacctct tttcttagtc 2892361 aaaataatga tgtttctcta aaaattcctt tgctacgaca gacggctcct tcagcttgcc 2892421 atccacctca taattaagtt cctgcatcgt ttccgtgtcg atttgcccaa tcagcttatt 2892481 gatcacacct tcaagttccg gatgctcctt aagcaccttt tccggaatca ccggtgaaca 2892541 gtcatacggc ggaaagaaac gcttatcgtc ttttaagatt ttcagatcat atgctttaat 2892601 ccgtccatcc gttgaataag ccaaaaccgc atccattttc ccgtttttga ctgcgtcata 2892661 gactagcccg atctgcattg gataagttgt gccgaactca aagccatatg tgctgacaaa 2892721 gcctttatac ccgtcgcctt ttcgtttcag ccaagcattg tcgacgccta atttatattg 2892781 ggaagcattt ttcttcaggt cagacacggt gttaatatgc tccttttccg caaacttttt 2892841 tgttacggtg aaggcatatg tgttatcaaa gccgtaggaa tcaaaccatt tataagaaaa 2892901 gcgcttttga aactcgttct gcacaatgtt cagcgctttt ttcggatctt tctccgcttc 2892961 cttgccgagg gtgcttgtta aatctgttcc ggaatagcgc gtggctgaaa tatcaatgtc 2893021 accgcccagc atcgcttggt gctgaacata gtttgagccg aggtttttca ctaaagcagt 2893081 attcaaatct gtatcatgtt caataagctg cgcgatcata ttcgctacaa tttctgattc 2893141 tgtcatgctc tgcgccccga ttttgatcgt atcgtcagaa gcgccgccta gacccggcag 2893201 agagcagccg cctagcagca tgacaaagac gagagcaaac gcgccaagcc atttgatttt 2893261 tgtcattttc aacagtgcca actccttacg atacttcctt catcccttgc aagcctttcg 2893321 gcgtcacctt tcgttctgtc acagccagaa cataatcaat aataattgcc agaattgtga 2893381 caggcacggc accgccaatg atatattcag gctggtatag gttcagtccg ataaaaatat 2893441 agtccccgag gccgcctccc ccgataaacg acgcaagtgt cgcccagcca attaggtaga 2893501 tcgttgatgt gcggatcccc gccatgatga tgggaatcgc cagcgggatt tcaacgagcc 2893561 gaatctgctc ccagccggtc atgccaattc ctttccccga ttccaggagg tttttattta 2893621 cacctttaat gccggtatac gtattgcgca ggatcggcag taccgaatag aaaaataaag 2893681 cgacaatcgc aggcactttt cctacgccga gaagcggaat aaaaaaggct aaaatcgcca 2893741 gactcggcag ggtttgcaca atgtttacga aaccgataac cgcacctgcg ccttttttca 2893801 ttctggtaag agcaacgccg agcggcactg caacgataat gcccaataca acggctatga 2893861 gtgaaatata taaatgctct cctgttttat acagcagctc tccgccgttc gtttgcaaaa 2893921 aagtcatcat ttgattcatc ttaaaagagc tcctcccctg gtcagatcgt catgagctgg 2893981 ttttcctcgt cgccccaaat ggaatcgtat acgatatcaa cgaggctcgc tcttgtcaca 2894041 atccctgcta aatggttctg ttcatcgacc accggaacat acttgatccc ctgcttcaaa 2894101 atttttcgga ctgtatcgcg aagaagcgcc cctttttgaa cggtatatat atctgaacgg 2894161 tatacatcgc caacgatgct cgcttttttg cggttttgat caatcatttc cacatcaaca 2894221 tagcccttca gcacgttttg ccggtccaca acgagcagcg agtcaacacg tttttctctc 2894281 atcagctgaa tcgcctgaga aagcgttttg tccgcagata ccgtcaccgg cgttctgttc 2894341 atcatttgct ctacccgctc gatatccggt cttgactgaa tcaggcgctc tttcccgata 2894401 aattcttcaa caaactcatt tgccgggttt cgaagaatct catcaggtgt gccgacttga 2894461 acgatttctc ccgcttttaa tatcacaatc ctgtcagcaa gcttaatcgc ttcatccata 2894521 tcgtgggtta caaacacaat cgttttgttt aaggttctct gcagtttttt gaattcttcc 2894581 tgaagggaat cacgcgtaat cggatcaagc gctccgaacg gttcatccat taaaatgaga 2894641 gggggttccg ctgccagggc gcgcagcacg ccgattctct gctgctgtcc gccgctgagc 2894701 tcatgcggat aacggtctaa atactctggg cccatatcca caagctttaa cagctcgcgc 2894761 gcccgttctt tccgtttttc ctcaggccat ttcagcagct ttggtacgag tgagatgttc 2894821 tgctggatgg tcatatgggg gaacaaacca atctgctgta tcacatagcc gatttttctc 2894881 ctcagctcaa ccgggtcctg ttccataata ttttctccgt cgataaagat ccttccagac 2894941 gatggttcta tcagtctgtt gatcatcttc atcgtcgtcg tttttccgca gccgctcggg 2895001 ccgataaaac agataaattc accttttgca atatctaaat caatgctgtt cacagctttt 2895061 ttgccgcctt tatatacttt tgacacttgt tccaatttca gcaatccgtg cacctccgca 2895121 ggtttccttt aaattttctg aaaagtataa tccttattat agtttgaact ttgtaaaata 2895181 aaaagtttac aatgtgttga aattatatgt tatttataga ttatttattg ttatgaccga 2895241 gacggaaagg gtgttcttac aattactccg gatacctccc acttcctctg cattcagcta 2895301 ttttcaacac caggaagaaa tatgatatat tgacaccatc aattgccatt tgaagggatg 2895361 atcagctgtg aaaaaaaccg ctctcgacat cattgaacat gctgaagagc atctcattga 2895421 gaagattgcc gaaaatatgc atacgtttgg aatgccttca actgtcggac gtgtgctcgg 2895481 aattatttat atgaatcgaa aaccaatgac cttaagcgag ctctctgagg caacgggcat 2895541 gagcaaaaca cggatgagcc aggttgtccg ggaaatgatc gatgccaata tcgccgaaaa 2895601 ggtgtttgaa aaaggcgtac gaaaagacct ttatgacgtc gagcaggatt attatcaaac 2895661 cttcatttct ttatttgcgg cgaattggac aaaggtcgtg agcaaaaaca aagtgctgta 2895721 taaaaaatta aaccgggagc tgagtgatct tttacaaagg gacgggctta ccccggaagc 2895781 ggaagagaaa gtcaatcagc tgctgaatga attaaaagaa tggcttcatt actatgattg 2895841 gctgagcagg ttgattgaat tttttgagag tgaggaagtc tttcggtatg tgccgaaaac 2895901 aaaagaatgc agctctctaa aataagagag ctgctttttg catcatgaag ttaagaccgg 2895961 aaacatgcct ttcagcccgg caccaatcat cccgaccgca accacggcta agattaatcc 2896021 catcagtctg gtaatcacat tcatctcggt ttttccgagt ttgctgctga taaaagcaga 2896081 atagtggaaa aagagaaagg tcagggcaat aacggcggct atgccgatca tgacagccgc 2896141 ataatgacca atgccgctat gtccggcgga aaggctcatc actgttgcaa tcgttccggg 2896201 cccagcaatg atcggaatgg ataaaggtgt gactgatata tccgcttttt ccttgctttc 2896261 cttatgttca tcatggtgaa gagattgcac gtgcgattct ttcgcattca atagattata 2896321 ggcaatgccg aaaatgaata tgccgcccgc cactcggagc gcgtgaatgt tgatatcaaa 2896381 cagtttaaag ataagatgac cgaaaaccaa aaaagctgcg agaataaaaa aggataaaat 2896441 agctgccttc cgggcaatcg cttttctttc cgctgcagta tagccttctg tcagcgtcag 2896501 aaatatcggt acgtttccga tcggattcga tactgcgaat aaagaaatga agacgtgaac 2896561 gataaatgag aacatcatat acctccttgt tgatagtctc tgcacaggaa atagaatgat 2896621 tctccaccct tttacccgga ggcgatttcc cggtaaacct ttatagcctg tcagaaacgc 2896681 gccatgctac aatgaagtga caaattgaat aggaaggacg tatacagatg ttcaaaaaaa 2896741 ttgcggcaga tgccttgggc ttatctgata tcggaaaaat tatcgaacct caggactatg 2896801 acaaaacaga cgcagatgac tatgtcatgc atgaagataa tgagaaaatt tatttcttga 2896861 ttaaaacaaa agcagacgag tattgcttta cgaacctggc cctgatccat gtggacggcg 2896921 aacgcgccac ttcctcaaaa cgaacgttga aacgctatcc ttattcgcaa tataaaatct 2896981 ctgacgtttt tcttgaaact gccggaaaag tggatttgga tgttgaaatt aagttcaagc 2897041 tgggcggtga acaattcgac attgatgtcc acaaagacca gattgaaaag ttaaaagacc 2897101 tttataaagc actgcttcgc atcgctgaaa caacctatga aaatgacatt ttaatcaatc 2897161 aagcggagca aagcttagat aaagcagtga cgattcttca ccatacccgc cctgagcacg 2897221 tcaatattga aacgcaatac aaagagctga ccgaattcgg attcacttgg ctgacatccg 2897281 ttcgctcgca gtatcatatt aaggattttg gggatgtatt tgagaaatat attaataact 2897341 agataaaaaa agacacagct gctatcgtgc tcgtgtcttt ttttgtatga atattgatta 2897401 ctttacaact tttttctttt ataataaaac tattagtcta ttttccctat attacagata 2897461 aaggagttat tttatgtatt gtcctcaatg cggccatcaa acagatggcg gaaatttttg 2897521 tgagaaatgc ggatcaccgc tccccggtca atcaggccac cagcatgcag ctcaaactgg 2897581 agccgctgca aagcaagcag caaaacagtt cggttcattt gtcttatccg tcctgaaacg 2897641 cccttatcag gaatgtaaag caacaggcgg agaacagctg atcagcgcaa tcattacgat 2897701 ggttcttttc agtttgctga cccctttgat gttttatatt cttttttcag acggtcccgg 2897761 aagcgtaagc tttacagcaa tcttcttaga gccaaccatt tattttattt tatttctatt 2897821 tggcctgcat gcatgcatct ttttcgccct gaaaatcgcg ggaaaccaag tgtctttcaa 2897881 ggattcattc tcaagattcg gagcatttct tattcctttt acggctattt tgattcttgc 2897941 ccttttcttc tttttattac atacagacat ttgctttacc atattagccg ttggtttaat 2898001 cggtgcattc ttcgccattc ctcctgcgat gctgagcagt taccagcatt catataaagg 2898061 gaaggttgat ttcatttact caacgattgt gatttatctg atcatctgcg ttacatttca 2898121 gcttattatc gaacactatg tcaaagaaat tttccgttat atgctctttt aaaaacaacc 2898181 ccatcacctg ctggtgatgg ggttgtttta ttgaatagac gttaagtaaa ttcttccgtt 2898241 cttcactacg ccggtgtagg tccagttata tgttctgagc tttggactgc cgcctgattt 2898301 tgtgatatag aattcttcat acgtcttaat cgtgatagcc gacccatttt ggctccagct 2898361 tttcacttca tagttattaa agtcttctgt tgtcccctct ttatttaatt tcgacacgag 2898421 atgctgctgg tcggaataaa gggaactgcc tttttcaagg ctgtcttcca tcagtgagaa 2898481 attattttga ttcacggcat ctgcctgact ttgcagataa ctgcccataa ataatgtcac 2898541 ttgttcatct gtaacatcgc cgcttgcaga gctttcactg cctttgtttt tcgagccagc 2898601 ccaggcggaa gtgtatgtct ctggtttatc atttttgatt ttctttatat ttgtgcctgc 2898661 agattcgaat gttgattctg catcttcgaa aatccacttt ttctgttttt tatcatatga 2898721 aagaagatat tcataactcg gactgtcgtc agtcatttca gactttgtat agtcgttata 2898781 cgaagaagac tggtgaagtt cttttcctgt taccgatacc tgccacgttc cgtcgttttt 2898841 ctgagagagg gcaaatgtgt ccaggtcaaa atcagtttcc aagtatctat cttttaagta 2898901 tgaatccgcg cttttcatag aatcgacggt gtccttcgtc tccgccttcc aattggcact 2898961 tgcctctgtc atctgggctg tattcccatc agatagagct ttggagtatt gttttgttgt 2899021 tttgacaatt gtgttcataa tctgttcctg tgtatcttga tcaggaatta acgttaactc 2899081 catttcttta tcatcgatcg gaacgccggc agtttttgtt tttccccacg gaaattctgc 2899141 ctcgactgaa gctgtcattg atccatctgt cagcagcgga ccatatgtta cggatttgaa 2899201 cggatcttta tgaattgatt taccgttaat cagcaaatct cccttcccgc tcttgatgtc 2899261 attcgctaag ctgaatgtca catcgtctgc ttccaatgag agatcaacac gaaagctgct 2899321 atcgccaatc gcctgaatgt cttccttttt cacaaggtca acgacatcgt ttttcagttt 2899381 ggctgagact gtatattcgc cgggaatgta cggaccaagg gtttgtgctt gatctgcttt 2899441 ctttacagat ccggcttcct ctttattgac atatagatcg gtatttttat aattgctgct 2899501 cacttcaaaa taaacaggtg ctacctttaa gtcataatgg tcaaatacca gcaggctttt 2899561 cccgtctttt tccgcatata cgatatcctt ctgggctgtt tcatcacgca gcgatgcaaa 2899621 aagttcatct tttttgtctg gatgatcctt caaatatgta agaaacggtt ttacattatt 2899681 tttagtgagt ttaagattgt catttaccgg tgtaagcaga gtcgcgattt ggtcctgatc 2899741 cccatcattt acggcctgtt caaacttgtc tactaaccta tcctttgaag taaaatacgc 2899801 tccggtttta tatgcggcga ataatataac gcacgccgcg gcaatgctgc tccataaaat 2899861 gatggttttc ttagggatcg gttttcgcgg agcctgcctc gtttctgcag tgctagctgt 2899921 ttcttgattt gcctgtttgc tgccccctcc gatcggggtg ccgcattgtt tacaaaactt 2899981 ggctccttca ttattctggg agccgcaatt cttacaaaat aacatgactt tcctcctatt 2900041 ctactaattt gataacattt actgcttttc atattttata ataaaacaga atgaaattgg 2900101 gaacgaatga aaaaattaaa tgtctatcag actaaaaagg tggaatgaat atgcaaaagc 2900161 tcaggattga attaggagaa gaaacaaatg acgaattata tgatctattg ctgctcgccg 2900221 atccatcgaa agacattgta gatgaatatc ttgagagggg agaatgttac acagcttggg 2900281 ccggtgatga gcttgcaggg gtttatgtat tgctaaaaac aaggccgcaa acagttgaaa 2900341 ttgtaaatat tgcggtaaaa gaatctcttc agaagaaagg ctttggcaaa cagcttgtac 2900401 ttgacgccat cgaaaaagcg aagaagctgg gggcggacac gattgaaatc ggaacgggga 2900461 attcgagcat tcatcagctt tccctctatc aaaaatgcgg attccgcatt caggcgatcg 2900521 accacgattt ctttctcaga cattatgatg aggacatttt tgaaaacggg attcaatgcc 2900581 gcgatatggt aaggctttat ttggatctct gaaagcataa aaaagccgcc gagagaaaat 2900641 cccggcggtc tttttattac ttgtttaagt tgtagaaaga gttgataccg tggtattgag 2900701 cagtttcagc caactgatct tcgatgcgaa gaagctggtt gtatttcgca acacggtccg 2900761 tacgagacgg agcacctgtt ttgatttgtc ctgcgtttgt tgccacagcg atgtcagcga 2900821 ttgtgctgtc ttcagtttca ccagaacggt gagagataac agctgtgtag cctgcgcgtt 2900881 tcgccatttc gatcgcatcg aatgtttcag tcaatgtacc gatttggttt actttgatca 2900941 ggatagagtt gcctacgccg tttttaatac cttcagaaag ttttttcgtg tttgtaacga 2901001 agaggtcgtc accaacaagc tgaacttttt tgccaagacg ctcagtaaga agcttgtggc 2901061 cttcccagtc gttttcgtca agtccgtctt cgatcgagat gattgggtat ttagaaacaa 2901121 gctcttcata ccagtcaacc atttcagcag atgttttcac aacgccttcg ccagacagat 2901181 ggtatttgcc gtcttctttg ttgtagaact cagaagatgc agcatccata gcaagtttaa 2901241 cttcttcgcc aggtttgaag ccggcttttt cgattgcttc aacgattgtt tgaagcgctt 2901301 cttcgttaga accaaggttt ggagcgaatc cgccttcgtc acctacagca gtgtttaagc 2901361 cttttgcgct taatactgat ttcaggctgt ggaagatttg agcgcccatg cgaagtgctt 2901421 cacggaagtt aggagcacct acaggcatga tcatgaattc ttgaatatcc acgttgttat 2901481 cagcatgctc tccgccgttt acgatgttca tcatcggtac aggaagcgtt tttgagttga 2901541 atcctccaag gtattggtaa agaggaatct gtaagaaatc agcagcagca cgcgcacaag 2901601 ccatagatac gccaaggatt gcgttcgcac caagtttgcc tttgttttca gtaccgtcaa 2901661 gctcgattaa aagctgatcg attgcgtttt gttcagttac atcaaagcca agaagctctg 2901721 gagcaatgat ttcgtttacg ttgttaacag ctgttaacac gccttttcca aggtaacggt 2901781 ctttgtcgcc gtcacgaagc tcaaccgctt cgtattcacc tgtagaagct ccgcttggca 2901841 ctaatgcgcg gccgaaagct cctgtttctg tatatacttc aacttcaact gttgggttgc 2901901 cgcgggagtc taatacttcg cgtgcataaa catcaacaat gtatggcatg agttttgtct 2901961 ctccttttga ttttcaaatt atttttgaat taaagatgtt cctgtcattt ctttcggttt 2902021 ttcaacacca agaaggtcta ataacgttgg tgcaaggtcg cctaggattc cgccttcacg 2902081 cagcgtaatg ccttctttcg ttacaatcac agggactggg tttgttgtat gcgcagtgtg 2902141 cggttcgcct gattctgtaa tcagaatgtc agcattaccg tgatcagcgg taatgatagc 2902201 gtgtccgcct ttagcaagga tcgcgtcaac gacttcgccc aagcattcgt ccactgcttc 2902261 aattgcttta attgttggtt caaccattcc ggagtggccg accatatcag ggtttgcgaa 2902321 gttaagaatg atcgcgtcat gcttgtcagc ttcaatttct ttgacaagcg cgtctttcac 2902381 ttcatacgca ctcatctcag gcttcaagtc atacgttgca actttaggcg agttgatgag 2902441 aatacgctct tcacccggga attcagcttc acggccgccg ctcataaaga acgtgacgtg 2902501 cggatacttt tcagtttctg caattcgaag ctgttttaac ccgtgctgag ataatacttc 2902561 tccgactgtg ttatcaagat ttatcggttt aaacgctaca tagccgtcaa ctgtttcact 2902621 gaagtgagtc aggcagacga aatacaggtt ctttggataa ttctcgccgc ggtcgaagtc 2902681 acggaagtct ttgtttgtga acgtgttgga aatctggatg gcgcggtccg gtctgaaatt 2902741 atagaaaatc acagaatcgc cgtcttggat tttcgcaaca ggctcaccgt tttcttttgt 2902801 gatgacagat ggaatcacga attcatcgta gataccattt gcatatgaat catcaacaac 2902861 atccagggcg ctgcggtaag atgggccttc gccgtacgcc attgcgcggt acgctttttc 2902921 tacacggtcc cagcgtttgt cgcggtccat agagtagtaa cgtccggaaa tgctggcgat 2902981 ttcacctaca ccgatttcct tgatttgatc gttcaactgg ttgatgtacg ttttcgctgt 2903041 ctgcggacct acatcacggc cgtcaaggaa gccatggata taaacctttg tcagcccttc 2903101 ttttttcgca agctttaaca gtgcgaataa atgattgata tggctgtgca cgcctccgtc 2903161 agataaaaga ccgaacaggt gcaaggcttt gttgttttct ttcgcgttgc tgatcgcgtc 2903221 aaggaatgtt tgattgcgtt cgaactctcc ttcacgaatg gcaacattta cgcgtgttaa 2903281 gctttggtac acaatacgtc ccgcaccgat atttaagtga cctacttcgg agttccccat 2903341 ttgcccttca ggaagaccta cagcctcgcc tgaagcagtc aaagtttgat gaggatactg 2903401 gttccaatag cggtcaaaat tcggtttttt cgctaaagcg actgcgttcc ctactgtttc 2903461 gttacgtaat ccgaacccat caagaatgat gagtgcagct ggttttttac tcatattgac 2903521 cttcctccaa taattgaacg aatgactgtg gctcaaggct cgcgccgccg accaaagcac 2903581 cgtcaatatc ggactctgcc atatattctt taatgtttgc aggctttacg cttccgccat 2903641 attggatgcg aagcttgtct gcagcttctt ggctgaagct ttcagcgacg gttttacgga 2903701 tatgcgcaca cacgtcattc gcatctttcg ctgtagaaga tttgcctgtt ccgattgccc 2903761 agattggctc atacgcaata acagaagcag caacttgttc ttcagaaaga ccagcaaggc 2903821 cttttttcac ttggtcagca acaagatcat ttgttttgcc ggcttcacgc tcttcaagcg 2903881 tttcacctac acagatgatc ggcacaatgc cgtgtttgaa agctgcgtgt gcttttttgt 2903941 taactgtttc atcagtttca gcgaacattt cacggcgctc agagtggccg atgacgcagt 2904001 agtcaacgcc aaggtctttc agagcaaccg ggctgatttc gcctgtgaac gcgccgcttt 2904061 cttcgaagtg catgttttga gcgccgactt ttaggtcagt gcctttcaca gcagaagcaa 2904121 gcttttctaa gaaaagcgct ggcgcgcaaa caacagcttc agctttgtct gctgctggaa 2904181 tggaagattt cacttcttca acgaagctga cagcttcgcc gagtgttttg ttcattttcc 2904241 agttaccggc gataattggt tttctcatct gttccacttc cttatagcag ttttgagatt 2904301 atttatcgtt cagtgcagct acccctggaa gctctttgcc ttccataaac tcaagggatg 2904361 cgccgccgcc tgttgagatg tggctcattt tgtcagcaag gccgaatttt tcaaccgctg 2904421 ccgcagagtc tcctccgccg atgacagagt atgtatcttt cgcctctgcc aatgcttccg 2904481 caaccgcttt tgttccttga gcgaacaagt cgatttcgaa tacgcccatt ggtccgttcc 2904541 acacgacaag tttgctgttt ttgatgacgt cagcatacgt ttcgcgtgtt ttcgtaccaa 2904601 tgtcgattgc ttctaaatca ctagggattt cagagatcgg cacaattttc acgtttgcat 2904661 cgttagagaa atcatctgca acgagtacat cttcaggcat gtagaagtta acgccttttt 2904721 ctttagcgcg gtccataaat gatttcgcaa gctcgatttt atcctcttca agaagagatt 2904781 tcccgacttc atagccaagc gcttttacga aagtataagc aagacctccg ccgatgatca 2904841 ggttgtctac tttatcaaga agactttcga ttacaccgat tttgtctttt actttcgctc 2904901 cgccgatgat cgctgtgaac gggcggtcag gattggaaac cgcttttcca agtacatcaa 2904961 gctctttttc cattaagaaa cctgcaactg ctggcagatg ctcggcaatt ccagctgtag 2905021 atgcgtgagc acggtgggca gcaccgaatg cgtcatttac atatacatct gcaagctcag 2905081 caaatgcttt tgcaagctca ggatcatttt tctcttcacc aggatagaaa cgtacgtttt 2905141 ccaatacaag aacgtctccg tccttcatct cagaaatttg tgcttttaca gcatcgccgt 2905201 atgcttcatc cgcttttttc acttctttgc caagcagttc gccgagacgt gcagcgacag 2905261 gagttaaacg aagctcctca accacttcgc ctttcgggcg gcctaagtgg ctcgcaagaa 2905321 ggacttttgc gccttggtct gcaaggtgtt tgattgttgg aagcgcagca cggatacgtg 2905381 tatcgtctgt tacttccccg tctttcattg gaacgttaaa gtcaacgcgg cagaatacaa 2905441 ctttgccttt tacgtcgatg tctttgagag tttttttatt catgcctagg agatcctcct 2905501 tcaaaatggt ttgcatacag cacgaaaaac gtgaaaccgt ctgttcaagc gataactccg 2905561 ctagggcaga tcgcagtctt tttcggcaca gggcagttcg tctaaaagcc agggcagcgg 2905621 ccttaggcga aagcgccggc aaagctgctt aaaacgcggt cgtttctcta tcacagagcg 2905681 ttttctgaaa gccggtcttc atggaaaaag ggaaagggag tccgtcccct tcccttgtcc 2905741 gctttcatta tagcgcttct attcgaaaga accaagtcag gtcctttttc agctataaat 2905801 taaagacctt tttttgcgat gtaagctgca aggtcaacaa cgcggttaga gtagccgctt 2905861 tcgttatcgt accaagagat tacttttacc atgctgcctt ccataaccat tgtagaaaga 2905921 gcatcgattg tagaagagtt tttgtttccg ttgtagtcgc cagaaactaa tggctcttcg 2905981 ctgtagccaa ggattccttt aaggtcgcct tcagccgctt ctttaagagc tgcgtttact 2906041 tcttcagctg ttacttcttg gttcagttca gcaaccaagt caactagaga aacgtttgga 2906101 gttggaacac gcattgctcc accgttcagt ttgcctttta gttcaggaag aactagagaa 2906161 actgctttag cagcaccagt tgatgttggg atgatgtttt cagctgctgc acgcgcacga 2906221 cggtagtctt tgtgcggaag atcaaggatt tgctgatcgt ttgtgtaaga gtgaacagtt 2906281 gtcatcatac cgcgtttgat gccgaattta tcgttaagta cttttgcaaa cggcgcaagg 2906341 cagtttgttg tgcaagatgc gttagagata acatcgtggt tagccgcatc gtatttatct 2906401 tcgttaacac ccataacgat tgtgatatct tcttcgttag caggagcaga gatgattact 2906461 tttttcgcgc cagcttctaa gtgtttcgca gcgtctgcgc gttttgtgaa gaaaccagta 2906521 gattcaacta cgatttcaac gccttgtttg ccccagctaa gtttagcagg atcgcgttct 2906581 gcagaaactt caattgtttt gccgttaaca acaaggttgt taccgtcaac tgaaacttca 2906641 gcgtctaatt ttccgtgtac agaatcatat tgtaaaaggt gagccagcat gttagcatct 2906701 gttaaatcgt taaccgctac tacctcaact tcaggattgt ttaatgctgc gcggaatacg 2906761 ttacgtccaa tacgaccaaa accgttaata ccgactttta ctgccatgat tgtttcctcc 2906821 tttaaataag tgagagatat ttatattgag ggattattca tcccttaata acttctttgc 2906881 ggctccttcg tctgtgacga gaaccgtgtt gcgtggcttt ttaaagtaag cctcgatcgc 2906941 ttcggctttt gatgatccgc ccgctaccgc aataatatcg gggatggcgt ctatgtcatc 2907001 cagctgcatt ccgacagaat gcactttgtg aaccacttcg ccgtccgcgt taaaatagta 2907061 gccgaacgct tccgtcaccg cgtcgttatc atctattttc tttaaatctt ctaaaggcgt 2907121 gtttctgcgc tgagccatag ttttagcttc gccgattccg tgaaccagca tactcgctga 2907181 tttaatggtg ttcagcacct ctttgacaga aggctcttca ataatagatg aataggcgcc 2907241 ttgtgacagc tgtcccggaa caaacaaaag ccggtaagtg cctgaagcct tctccgccat 2907301 atgcgcgcat atggtgttcg cctggttttt cacgtcttcg cctaaaccgc ctcttgcagg 2907361 cacaaacaaa agctcgcggt ttttagaatc cggcgtcatc atttcggcga cagcttcaat 2907421 tgtcgtaccg ccagttacag cgacgatatt tttgcctgaa aatctttttt tcatacatgc 2907481 gacagccgct cttcccattt cttttttgac ccatggggat tgatcgctgt ctccggatac 2907541 gataatggca tcctttagat ttaaacgttc ttttaatgtc ttttccaaaa gagtcaaacc 2907601 taaaacatct ttcatcgtat cttccaaaac agaaagcagt tcatagccct cttctgtcaa 2907661 tgtcatgccg tttgtcttaa tatcgaccag gttctgttcc tttaaaaact gaacctcgcc 2907721 cctcagcaca cgctcgctga ttccgagact ggcagacagg cttcttcgcc cgatgggttc 2907781 tgtcagcctg atatactgca agatttcaaa cctcttttgc ataacgagca gaagatcagg 2907841 caataatttt ttttgagctt gtattaactg gttcatgact caaacgttcc ttcctttttt 2907901 gctggacatt atatgtcccg ctatgacaaa aaacgtcccg tcatagccaa aaaaaatcat 2907961 ttctgctttc tttaattatt ttaacagggt ggaattgttt attcaactgt taagagccaa 2908021 ttcatcgaca atattcgcag agttttcatg ccgcgtcgtt ttatccagca atattttatc 2908081 ctatatatct ttatcttata cagaaagcgc caaatggtgc atcccaatat aaacagccct 2908141 tcccgtagaa agggctgttt cattaaagcg ttttcatttt atccaaagct tttcaatttc 2908201 ctcgagcgat ttgttcttcg tttctggaca gatcgtaacg acaaacagga aacaaaggat 2908261 gttaatcacc gcaaagatcc aaaatgtata ggcgagcccg aaagaatcga tcatcattgg 2908321 cacaaactgt ccgatcgccc agtttgctcc ccataaaaag atggtcgcaa tgcccgcggc 2908381 ccgcgcacgc agatggttcg ggaagatttc agaaatcata atccatgtga tcggtccgac 2908441 cgagacacag aaagcagcga caaaacctaa tataaggacg atcatcatga tcccgcttgt 2908501 taactcaaaa taaaacgacg tcccgattaa aatcataaaa atagccataa aagcagaacc 2908561 gatggacatc agtttttttc gtccgacttt atcaatcagc aacaccgcaa taacggtaaa 2908621 aataacttct acaaccccga cgatacaagt cgtcacaaat ccggcgtttt gcccgaatcc 2908681 catcatttta aagatttccg gcccgtagta agtaatcgcg ttcatgccga tgacttggtt 2908741 aaacagcgcc agcaggattc caatgacaag cgcctttctg agacccggct taaacagctg 2908801 ggagagcgac cccatttgtt ctatttttaa agagttctca atgttcttta attcttcttt 2908861 tgcaacagtt tctccattaa tacgtgtcag gatctttaaa gcttcatttg ttttgcccgc 2908921 tttcgccagc catctcggac tttccgggac gacgagcagg acaaggaaaa aaatgacgga 2908981 tggcaccatt ccataagcaa gcatccatct ccagccggtg tgcacgcccc attcgtatgt 2909041 tccggaccgc tgcacagcta gattaataaa gtatgttgcg gaaataccca gtatcgtaaa 2909101 gagctgatat aacgaagata aacttccgcg tatagcgggc ggtgccgctt ctgtaatata 2909161 cgtaacagag agcgatgagc ccatcccgat tcccagcccc ccgataatcc ttgcaatgat 2909221 taaggtggac acgtcttgag aaagcgctga aacgattgct gatatcgcaa ataacaaagc 2909281 ggctgtcatt aaaatttttc tccggccgaa tctgtcactt aaaaatccgg atatcccgac 2909341 gcccacaact cctccaatca taatgcttga aatgacaagt ccctccataa acggactcag 2909401 gctgtataaa tctttcagaa aaccgatggc gccagaaatc actgccgtgt catagccata 2909461 caataagccg ccaagccccg ccgcacatga gatcaaaatg acaaatccca ttgaatggct 2909521 tcttgttaca ggaacatttg gttctaattg agttggagta ttcttcattt ccctgccctc 2909581 ccgaatgttg agtaaagcgt tttcatttaa accttcaatt gtacgtactt atattaaaat 2909641 ttaacgaaaa ttacatttaa ttagtacgta caaatataga ataatcttgt ttgcattttc 2909701 tgtcaatgtt ttcttacaaa gaacgctgtg atatactgaa atttgtccgt atacattttg 2909761 gaggaatgga tatgttacca aaatacgcgc aagtaaaaga agaaatcagt tcttggatta 2909821 atcaaggcaa aatactgccc gatcaaaaaa tccctaccga aaacgaatta atgcagcaat 2909881 tcggcgtcag ccggcatacc atccgcaaag cgatcggaga cctcgtatca caaggtctgc 2909941 tgtacagcgt gcaaggcgga ggcacctttg tcgcttcacg ctctgctaag tcagcgctgc 2910001 attccaataa aacgatcggt gttttgacaa cttacatatc agactatatt ttcccgagca 2910061 tcatcagagg aatcgagtcc tatttaagcg agcaggggta ttctatgctt ttgacaagca 2910121 caaacaacaa cccggacaat gaaagaagag gcttagaaaa cctgctgtcc cagcatattg 2910181 acggactcat cgtagaaccg acaaaaagcg cccttcaaac cccaaacatc ggctattatc 2910241 tgaacttgga gaaaaacggc attccttttg cgatgattaa cgcgtcatat gccgagcttg 2910301 ccgcgccaag ttttaccttg gatgatgtga aaggcgggat gatggcggcg gagcatttgc 2910361 tttctctcgg ccacacgcat atgatgggta tttttaaagc tgatgacaca caaggcgtga 2910421 aacggatgaa cggatttata caggcgcacc gggagcgtga gttgtttcct tctccggata 2910481 tgatcgtgac atttacaacg gaagaaaaag aatcaaaact tctggagaaa gtaaaagcca 2910541 cactggagaa aaacagcaag cacatgccga cagccattct ttgttataac gatgaaattg 2910601 cgctgaaggt gattgatatg ctgagggaga tggatcttaa agtgccggag gatatgtcta 2910661 ttgtcgggta cgatgattca catttcgccc aaatctcaga agtgaaacta acctctgtca 2910721 aacatccgaa atcagtgctt ggaaaagcag ccgccaaata tgtcattgac tgcttagagc 2910781 ataaaaagcc gaagcaagag gatgtcatat ttgagcctga gttgatcatt cgccagtccg 2910841 cacgaaaact gaatgaataa aaaaagcaat gtatgggtct ccccgctaca ttgctttttt 2910901 tatagctgtt atctgttttt ccaaacgtca gcgatgattt caaacgaacg cattctgtct 2910961 gcgtgttcaa aggtttctga gttaaccata atttcgtcag cctgtgtcgt tttgacgaaa 2911021 tcttcaagct tcgccttcac ttcttccgga cctccgacaa tcgtggagct cagctgctca 2911081 ttgaccatcg ctttttcata cgggctccag atttggtcca tatcctcaac aggcggttta 2911141 agctggttag gcgtaccgcg gacaagatca agaaaccttt gataatggga agtcgcaagg 2911201 tgctgcgctt tctcgtttgt atctgccgcg ataatggtga caccgaccat cgcatacggt 2911261 tcgtcgagca cgtctgacgg cgtgaaggaa ttgcggtaca gctccaaagc gggaaccgta 2911321 ttcgccggtg agaaatgggc cgcgaacgca aacggaagac caagttcgcc agccagacgg 2911381 gcgctgaagc cgcttgagcc cagcagccaa atcggcacat ctatgccctc tccgggaatg 2911441 gcgcgaactt gattgcgcac atttcctgac ggtttaaaat aattgcgcag ttcctctaat 2911501 tgttctggaa aatcctcccc gctgttgatg tttctgcgga gcgctctggc tgtcaattgg 2911561 tctgttcccg gcgcacgtcc aagccccaga tcaatccgcc cgggatacag tgtttccagt 2911621 gtgccgaatt gttcagcaat gactaatgaa gagtggttgg ggagcataat gccgccggaa 2911681 ccgacgcgga ttttcttcgt gcctccggca atatggccaa tcaaaactgc ggtggcagag 2911741 cttgcaacac cttctatatt atgatgttca gcaagccagt aacggtgata gccccattcc 2911801 tctgcccggc gcgccaagtc catgctgttt cggaatgatt ctgcaatcgt tcctccctga 2911861 acaaccggag ataaattcaa gacagaaagc aaggtatctt tgcgttggtt gttagacata 2911921 ttgttctcct ttgcaaatgt gttatcagta aacagcccaa agctgtcagg tcatgattga 2911981 aagaacttct atcacaccat aacacaactg cattcaggaa taaaagaatt tgattcgatg 2912041 aaattcgaac aatataaaac gaacggtttg gaacattatt ctgctccaaa caactcctta 2912101 gccatctcaa taaagagctt agccgccaga gaagcctcct ttagcgacgg aacagcaagc 2912161 tgcacatcac ggtatacctg cgggtccaat tccctggtca ccacatgctc tggcagcggc 2912221 atccccgaca tggacatttc tgataaaatg gccaggccca ggccttctct gatcatactg 2912281 atcgaggtgt tgatgttata gaccgtgaaa gctgggtgca gcgtagcacc cgcctgcctg 2912341 aacatatcga taaatggtga ttcatagccg ccgtcacaga cgatcatcgg ttcatggtca 2912401 agatctttca gcgtaatggc tgaatgactg gcaagcgggt gatcgtccct gagcacgaca 2912461 gccattttgt cttttttcaa atgaatgtac tccatctcct ctgttggata cagaagaatc 2912521 ccaacatcta tcatccgcgt atgaagccac tccttgactt catttacagt tccctcgtgc 2912581 agcacgagct caagtttcgg atatttttgt ttaaattcac tgatcagctt cggcataaaa 2912641 taagccgagg cagttgagaa tgtgccgata tggatcgttc ccagttcaag ccctttttcc 2912701 gctgctgcta cctgctcaac tttttcaatg ccttttaaga cttctctgat gtgtactaag 2912761 atctgttttc ccgtatccgt cagcatcagg ccattgcggc ggtcacgaat gatcagcttt 2912821 acatcaagct cagcttcgat cgcagaaatc gcatggctga cagccggctg tgtcatgttc 2912881 agcgcctgac ccgcttttgt aaagcttccc gtttcagcta ttttcacaaa aacctttaat 2912941 tgagtaatgg tcataacaat ttacttatgc tccttataaa aaagattcat tttatttatc 2913001 ttatgttcta ccgtatcata tgatggaaaa gttctacaag gagtgaatga acaatgaagc 2913061 agctcccaaa aacgcggaca gctctcctgc tcgcatttct cgtcatcatg tggggcgtca 2913121 attggccgct gtccaaagcc gcgctcgcct attctccgcc attattgttc gcgggcatcc 2913181 gaacgctgat cggcgggctt ttattagtca tagtcgcact gccgcgtatt cataaattac 2913241 gcttaaaaga aacgtggccg atttatcttg tttctgctct tttaaatatt acattattct 2913301 acggcctgca aacgatcggg ctgaattatc ttccggccgg cctgttttct gcaatcgtct 2913361 tcttccagcc tgttctgatg ggtgtatttt cttggctgtg gctcggcgaa tccatgtttg 2913421 taatgaaagt gattggcctc atcctcggtt ttgcgggagt agccgtcatt agtgctgcgg 2913481 gctttggcgg gcatatttct gtcattgggg ttctgctggc tctcggctcc gcagtcagct 2913541 gggcgctcgg gacagtatat atgaaaaaaa caggcagccg cgtcgattcc atctggatgg 2913601 tcgctctgca gctgacgatc ggaagcgtgt ttctgcttat ctccggcttt tggacagaaa 2913661 gcttttcggc gatccaatgg acagctccgt ttattacgag cctgctgttc atctccgtat 2913721 tcgttatcgc actcggctgg cttgtctttt ttacgcttgt cggttcagga gaagcaagca 2913781 aggtcgcatc ttatactttt ttgattccgc tcatatcaat cgtggccagc tccattttcc 2913841 tgcatgaacc gctcaccctt agcctcttgg cagggctgct gctgattgtc acgagcatct 2913901 gtctcgtgaa tacaaaatca aaagcgcaga aagctgcggc gattggtata aacgagaaag 2913961 ctgcacaata ataaaaaccc tcttgccgga tgcggcaaga gggtttctta tttactgatg 2914021 cttgcgtcct ttgaccaaat atgcaactgt aatcaaaagg tagatcgccg cagtaatgcc 2914081 ggtaatgaca attgatgttg tcatgatgac cccgatcaga atggcgagta atgccacaat 2914141 cgcaaaccat gtcgtgtacg ggaaccattt tacataatag gccggtgttt ccgtttgctg 2914201 ttttctcgat tttaaatgag cgaatccgat gatcagccaa atgaataaaa cggtatatcc 2914261 caatgatccc attaaataat taaatgtttg gcttcctgcg aacagagaaa tcaatacgcc 2914321 aatatagaga gaagaagtgc acatcagaat cgcaaacatc ggtacgtttt tcgatgaaag 2914381 cttcgagaag acctttggaa gccttccgtc acttgcctgt gtatacaaaa tgcgtgatga 2914441 tccgtataaa cctgaattca tagaagaaat gatcgccagc aggatgactg cattcatgat 2914501 atgatccgcg cccggaatgc ctaccatttt aaagaccatc acgaaaggac tttccggaac 2914561 ggaattgact tggttccatg gaatcaggct gacgatgatg aaaaacggca gcaggtaaaa 2914621 cgcgacaatc cgtgtcagtg tgctgcggac agctttcggg acaacctttt ccggattttt 2914681 tgtctctgca agcgttacac cgataatttc tgtaccgccg taagagtaga tgacgacaag 2914741 catcgccgtg atcagccctg tgccgccgtg cgggaaaaat ccgccgtggt ctgtcaggtt 2914801 ggaaaatccg gatgctgtat gatcaccgaa tgatacaaat aagagcagca atcccagaat 2914861 aataaagata ataataacgg taatcttgat cattgccagc caatattcag tttcggcgaa 2914921 gattttaaca gaaagcaagt ttacaatcgt gacgataaga gaaattccta atgccaacac 2914981 ccagatcggg cagcccggca gccaatattg aatgaaaatc gcagctacaa cagcttcagc 2915041 cgcaatgtta agcacccaca ttttccagta gatccagtcc aaaaagtaag cagcgtaatt 2915101 tcccaatacc tgctggacaa gatcacggaa ggttctggcg ttacggtttc gaacagccat 2915161 ttccgccagc ccctgcataa taaacagcaa aataatcccg ccgagcaggt atgcgataat 2915221 gacagatggc cctgccacat cgatcgctga gctgctcccc ttaaataaac ctgcgccgat 2915281 tgctccgccc agcgccatca tcataatatg gcgggacgtc atcgtgcgtt ttaacgtttg 2915341 attgtcgttt ttcatcctct tctacctctc cttctcgttt tcaaaaacaa aaaagcccgc 2915401 cgtctcctac ctaatctaat agataaagag acgacgagcc ttcggctgac cgcggtacca 2915461 ctcttgttga ttcttcatga agaatcctgc ttttgacctg taacgaaggt tagccgttaa 2915521 aacataggga atattcaatc tattccgttc cgtcttacca ctcccgggcg agttcaaaga 2915581 agaatcaggc tgcgtcgcac caccccgcag ctctctgttc tgatcacttt cttttactgc 2915641 tcccaatcta tgtgttttag ttttctgaaa aactcaaatt ttatgatctg aatatattaa 2915701 cataatatac gtgcttctct tttaactgtc aataacttca gagaaaaaag aaactgttat 2915761 tttgtccctt ttcgaatggc tttccaaaag gattctgact cgtttcctaa tgcgtaaact 2915821 gaaacacctg ctattttata ttgctttgcc agatggcttt tcgtttgaac ggttttttcg 2915881 ttttcatacc acacgacatg tttatgcttc tttttgtcaa cataagaaaa cgtcatcgag 2915941 cctgattttt tgttgaatgc cggctttgct ttttgttttt tgatgaggga tttgagctca 2916001 ttccattccc ttattgtgct ggtacttccg tcttttacat cccagtcata gccgtacgca 2916061 gggattccca tgatgacttt attggctttg atctttttga ctgaaaactg cagagagctt 2916121 ttgatccagt ttgtgcttgc cactgacccc ggctcacccc aaatgccgtg ttcatcgtag 2916181 gtcatgactt gtacgaagtc ggcatatttg ccgattttcg cataatcata cggccagctc 2916241 cagtcatcat ttttatcatc ggcgcttttg gccggaacgg ataccattgt tttaatatgt 2916301 ttcttattca aagcctgtga gacatattga atgaagttcg agtatgcagc gcggtcttct 2916361 ggatttactg cttcaaaatc gatattgatt ccgtaatatg agtgcttttt ggccagtgta 2916421 attaactgat ctgtgaatcg ttttttcgct gttttattgc tcatgacccg actcgctaaa 2916481 tctccgtcaa aatcataaat ggcatcatta tagtttgaaa tgacagccca tgtcttgatt 2916541 tttttctttt tcgcatatgt cagctgctta gttggggcat cgccaatgat ttgtccgttt 2916601 ttttcaaacg caaatgtatc ggttgcgatg gcattcatgt atgtatgata tttcgtaaga 2916661 gaattgtatg aagccgtatc cccagtcgtg tagcctactg tcataccggc tgccttcgct 2916721 tctccttttg tatacataaa cagaacaatc gcaatcgcca gtgaaaccgc tatgatcagc 2916781 cattttttca tcgcatttcc tcctgtatca agtcatactc ttctcatcgg ccaaaaaatt 2916841 ggaagttgaa gttttttcaa gcaaaaagcc cggcatatgc ctgccgggct tcctgagttc 2916901 agcggtcaga gacgagaata tatgctgcct ttactggtcc atgcaccccc acaactaaat 2916961 ccatttcaat gtcggctgag ttactcggtc cggtaatgta gttgatacat gaaggaacag 2917021 tgacaccgtt cgcaatgttt tggcggatga tatcactggc ttgtgtcatt ctcggtacaa 2917081 tgcttgattt cggcacgatc gcaatataag tcgttggcaa aaggctgaca gagcggccga 2917141 tgtcttttga ggagaagagg acaaccgtcc ccgactcagc caatgtaatt tcgctgaatg 2917201 taatccctac attggcttgc tccgcttttt taatattttc ctcgcctttg tcagcatccc 2917261 actcccagac cggcgttcct tcactcggcc agtccttggt gagcaggctt ttcagtccgt 2917321 attcttcaaa gcgggggtcc ttcggaatga tgacagggcc tccagaaaag cggctgactt 2917381 gctcgcgcag ggcatcgtaa aggccggttg aatccgtttc aatcagctct gtatggattt 2917441 tgacacaatg gtttttgagc actgtgacta agtcatccgc tgaataacct tcaagtgttt 2917501 tatattgcgg ctgatgcgcc cattcaggga ctgccacgcc tcctgttctt cgttcacggc 2917561 ccaggctgga tgcgattcgg tttaaaaagc tctcttgatt ctgaatggtt cccttcgtca 2917621 tcactgctcc tccttcgtgc gttcacttgt ttctctgtcc gcaaaccagt ctctgaatct 2917681 cgatttatgc ggtgccggga agtcgcgaat ctgggtccaa tttttaagcg ggccgggccc 2917741 tttcgaaatt ttttcgtcct ctgtaaaagg cgtcatggcg gccggcgccc attttgagcc 2917801 cattttgtaa agcgataagg aggatgcgcc aagtccgaat gctttcattg caagcttttc 2917861 actgatcggc gccctgcctt ctttttcgac gatattctga cgatgcttga gtagcagctc 2917921 atgaagcggg attttgaccg ggcaggcttc tgaacaagca gcgcacagtg aagatgcgta 2917981 cggcagctcc ttataatcgt cataaccgcc gagcaacggt gataaaacag ctccgatcgg 2918041 ccccgagtag attgagccgt atgaatgtcc gccgacatgg cggtacacag gacagacatt 2918101 gatacaggcg gcacagcgga tacattgcag cacagactgg aattccgttc caaggatatt 2918161 ggatcgtcca ttatcaacga tgacaagatg gaattcttcc ggaccgtcca cttcaccttc 2918221 cagcttcgga cccgtcaaag ctgtaatata gcttgtcagc cgctgtccga cagcacttct 2918281 agtcagcatg ctgactagca cttcaaattc agaaaatgac gggacaatcc gctccattcc 2918341 catgacggta atttgtgttt tcggcaaggt gctcacaagc cgtccatttc cttcattggt 2918401 cacaaggctg acggaacccg tgtcagcgat ggcgaagtta cagccggtaa tgccgatatc 2918461 cgcttccaga aactttttcc ggagaatggc gcgcgcatgc atcaccagct cttccggttt 2918521 ttctgtatgt tgatagtcca gtctttcttt aaacacatcg cgtatctgct ctttattttt 2918581 atgaagagcg ggcgctacga tatgtgacgg cggatcgtga tcatcaatct gcaaaatata 2918641 ctcgccgaga tcggtttcta cgacttcaca gccttccttc tccagcacct cattcagatt 2918701 gatttcctct gtgaccattg atttagattt cacaattttc ttcccgttct tcttttgaat 2918761 gacatcccga atataggaag acgcctcttc cgctgttttc gcgaaataga catgtccgcc 2918821 tcttttcgcc acattttcgg caagctgtcc gagatagaaa tcaaggtttt caaggacatg 2918881 ctgcctgatt tcctctgata atgagcgcca ctcctcccag tttcccagtt cttctgctgc 2918941 ctctaggcgc cgcgtccgca gacgctcctg tgcacctgaa acagcgcctc tcataaattc 2919001 attatcaatc ccctgtgata cccgctcttt aaaagcgtca gtaccgattt tcatcgccat 2919061 gatcctttcc ccctctgaat ccagttttat ctgctgttga gcacttcggc gatgtgcatc 2919121 actttgacat tcttatcttt tcggccaagc cgtcccccga tattcatcaa acagccgcag 2919181 tcagcaccga tcagcacctc tgctcccgtt tcctccacac attcgacttt ttcatcgacc 2919241 atctgctcag aaatctgcgc catcttgact gagaacgttc ctccgaatcc gcagcagtta 2919301 tgtttgcccg gaagctctgt aaactgcagg cccttcacat ggctcaacag cttcatcggc 2919361 tccttccgaa cacccagcag cctagtcata tggcacgacg tatgtaaggt cgcttttgta 2919421 tgaagggtcg cgccgacatc ctctacccca aggacgttca caataaaatc tgtcagttca 2919481 tacgttttat ccgccagctt tttcgcttta tcggcccatt tcggatcatc ctgaaacagg 2919541 tgcggatact cccggaacat cgttgtgcag gaacccgaag gactgacaac atattcggaa 2919601 tcctgaaacg tttcgatcat ccgtttcatt gcttttttgg cgtcatgtac atagccgctg 2919661 ttgtaagccg gctgtccgca gcaaatctgc ccttctggaa aatcaacctc gcacccaagc 2919721 cgctccagca gctcaaccgt tgcttttccg acatttgttt gaaacatatc aacaagacaa 2919781 gtgacaaaaa gtgagacttt catgatgaac ccctctctca tccccaatat atgatcaggt 2919841 catctgatga cctgagttaa aataactata tgaatatcgt acactattct gacaatggaa 2919901 ggaaagagtt ttctagggat attttcattt gtggcatatc aaaaacactc ccgatctccc 2919961 aggagtgcag tatatggtta gatccagccc ttttcctcag cgatgctggc ggcttctgtc 2920021 cgatttttcg cattaagctt ttggatgatt tctgagatat agtttcgaac tgtgccttga 2920081 gataaataga gctccagcgt aatgtctttt gttgtcttgc ctaaagccgc aagcctcaga 2920141 atttcttgct ctctaacggt tagcggattt tcgtctcgca tcatattaaa cgtcagctca 2920201 gggctgaaga cacgttttcc ctttacacat tttcgaatgg catcggccag atcgtcaatt 2920261 tcaccgtctt tcagcagata gccatgtgca ccggccttta cggcgcgttc aaaatatccg 2920321 gggcgggcaa aggtggttaa aataatgacc ttgctgacgc agcctttttt cattaattcc 2920381 tctgccacat tcagcccgct tcgaaccggc atttcaatgt ccataatgca tacatccggc 2920441 tccagcttca aaatagcatg tagcgcctct tccccgttta atgcttgtcc gatgactgtc 2920501 atatcctctt ctaaatcaag caaagatccc aaagcgccta aaagcattcg ctggtcctca 2920561 gcaataaaca gacgaatcat tcttttcgtc ctccaatcat tctgcttttt taataagcgg 2920621 aatcgtcagt gccacaaccg ttccgttatg gtctgaaacc gttaatcccc cttcaatgag 2920681 catgagccgt tcttccattc cccacaggcc attcccaaac attttctcct tcggcgctcc 2920741 ctttccgtca tcccgtatta cgatcctcat tttgtcagca aattgagaaa tggtgatggc 2920801 acagtgggtt gctttgctgt gcttgataat gttagtcacg gcttcccgca tacacatact 2920861 gataatattt tgagtgacgg gagatatcac tgaaaagtcg tcggctcctt cgtattgaaa 2920921 ggtaatgttc cccgctctta atatgtgctg aatgtttacg agctcctctg ttatcgtgac 2920981 cgttctcata tcagaaacca gctctcgaac ttgcttgagt gcggagcgtg aactggtttc 2921041 catttctttt gcctcaagct tggtccgttc tggatcagat gcagccagcc gctgaatgag 2921101 ctggcttttt aatgtaagca gcgacagggt gtggccaaga gtatcgtgaa gatcacgggc 2921161 gattcgaaca cgttcctccc ttttagagag ttcttttatc tgttcgttgg cttgtgcaag 2921221 cttagcttca agctcaatcc tccgaaacat agaacgaatt ccgaatggag aaatgagcat 2921281 aatgacgaga aacgggagaa cagaaaaaag ctcccgaagc gagaccgaat tcgcgataaa 2921341 ttggtatagg catggaaaaa gcagtataaa gattaaagcg cagaacgcac ggttaaaatt 2921401 cgttttctct ttgtaataac caacaaagtt tgccggaaaa aaacctaagt atatataggt 2921461 gatattgtaa aacacactat acatcaaaat aaccgccatt tgcacgataa gccaatatgt 2921521 aaacgaagct ttgcccacgc tgcagaataa ctggcgatat gccgctacaa aaaggagcag 2921581 cataccatat ccgatcccct gtttgacccc tgattctttt aataaagaga ggaacggcat 2921641 aatcgtatac accagaaaga tataagggaa aaacccgaat tccttcggga aaatagatat 2921701 tgcctttttc atgtattaca ccgcttcttg ttttcttctt atatatttag atagtagcat 2921761 gaagagcatc atataagcga ttaatatcag aatatttttc caagtcggac tcccaccccg 2921821 gacaagttcc cacgctccgc tcccgaaatg ataagacgga agccactggc caatgctctg 2921881 catcatgtca ggcatgacct caaacggcat ccacatccct ccgcctaaag ccagcagcat 2921941 ataaagcaca ttactgattc cggccgctgt ttctactttt ctcatgaggc cgattagtgt 2922001 gcctaatgct aaaaaaggca atgcgccaaa caaaatccac agtccgctca tcatccattc 2922061 aaacggtgac aaggcaatat cattgatgat tgcgccgaac agaaatatga cggtaattga 2922121 taaaacgtga atgacacttt ggccgatcat ctgagctgat aaatagatat gatccggaag 2922181 aggcgtaagg cggataaagg cggcccagcc ttgtgaccgt tcttgtacca ttcggatgcc 2922241 aagcgtcatg atagaggaac ccatcacgct gaagactgtc atcgacatca ggtaatgggc 2922301 ttcccatgca cgttgatcag ggacgttggt attcactaca tttgtaaaga aataataaaa 2922361 ggcaatcggc atgatcagag accaaagcac aaagtacttg ttcctaagca cccttttcat 2922421 ttcagcgatg ctttgctttt gcagcacgtt cactcacatc gcctccctgt tgccgtcagc 2922481 cagctggcga aatgcctcat cgagcgttgc ttgctcaatt cgaatatccc gtgcatgtat 2922541 gttttcttga aagatcagcg ccaacacttt gtctgtattt gatgtctgga tgatggttct 2922601 ctcatgctcg tggatcactc tctcgacttc cgggtgacaa gacagccttt ccaatgattc 2922661 acttgaatga agcgtaaagg aaacagactg tttttgaatt cttgagcgga tttgcattgg 2922721 tgagccgtct gcaacaagct gtccttcagt aaaaaatagg attcgctgtg cggcatcatc 2922781 tgcttcctgt aaataatgag ttgaaaaaat aatcgttttt ccttggtccg acagtccgtg 2922841 aatggtctgc cagaatcggt gtcttgatga agtgtccatg ccgactgtcg gttcatcaag 2922901 tataagcagc tccgggttcc cggcaagagc caaagcaaag ctcaaacggc gtttttgtcc 2922961 gccggataat ttttctgctc ttgttttcaa atcttctttg gtgagtgctg ttaacgaaac 2923021 gagttctttc atggacaatg gattcggata atagctccgg aagagttcaa ggatttcatc 2923081 caccttaagg cccggcatga cacttacttc ctgaagcatt acacctattt tttcacgaac 2923141 ctgttgatca tcgggaaccc ggttaaatag tttgatttct ccctcactcg gtttcagcaa 2923201 tcctaatatc atcgagacga cggtcgtctt ccctgcccca tttggcccga gaatggctgc 2923261 aatttctcct ttttcaatac tgaagctgat gttgtttaca gcggtttttc gctggaaatg 2923321 ttttgtcacg ttgcttactg ttactgcttc tttcatcaca tgagcacctc ctgatcgttt 2923381 acattgattg taaaatgacg gagaagacga tgttagtatg gggtgtcatg atgatggagt 2923441 gacaaatgtc atttttttct caccccggtg tctaggcaat cctcctcctg catcttccaa 2923501 ttcatccatc ttttctatct cccatgtcct ctttctttta aactgctgtg acattcatag 2923561 aaagatacac tcttcaaacc atccgagtgt tatgatagaa atattgaact ttatattact 2923621 ttccggctga aaggagccaa tcatgaacga agcgattttg tctagaaatc atgtgaaggt 2923681 gaaaggcagc ggcaaagcat ctatcatgtt cgcacctggt tttggatgcg atcaaagcgt 2923741 gtggaatgcc gtggcacctg cctttgaaga agatcatcgg gtgattttat ttgattacgt 2923801 cggttcggga cattcagatt tgcgcgcata tgacctgaat cgttaccaga cacttgacgg 2923861 ctatgcccag gatgttcttg atgtttgtga agctttagat ctgaaggaaa ccgtgtttgt 2923921 gggtcactcc gtcggggcct tgattgggat gcttgcatcc atccgccgcc cggagctttt 2923981 ttcccatctg gtgatggtgg ggccttctcc ttgctatttg aatgatccgc ctgagtatta 2924041 cggaggattt gaagaggagc agctccttgg cttgctggag atgatggaga aaaattatat 2924101 cggctgggcg actgtatttg cggcaaccgt tctgaatcag ccagatcggc ctgaaattaa 2924161 ggaagagctt gaaagccgtt tttgttctac tgatcctgtc attgcccgcc aattcgcgaa 2924221 agcggcgttt ttttctgatc accgagagga tctttcgaag gtaacggttc cctctcttat 2924281 tctccaatgt gcagatgata tcatcgcacc tgcaacagta ggtaagtata tgcatcagca 2924341 tctgccttat agcagtctga aacaaatgga ggctcgcgga cattgccctc atatgagcca 2924401 tccagatgag acgatacagc tgatcggcga ttatttaaaa gcacacgtgt gatataggaa 2924461 cgaaagggat agaggtgacc ctcttagatg gacaaacaat tgaatgatgc accatgcggt 2924521 ttcctcgctt tgtcagaaga ggggtcgatc atagctgcca accgcaccct tatcaagatt 2924581 ctggattatg aaccggagca ggttatcggc cagcacatga atatgatgtt gaccattccc 2924641 gcgcagcttt tctgccagct ttattttttt ccgcttttga aattggagca tcacatcgaa 2924701 gaaatataca tttccctgaa agcaagagat ggagaagaaa ttcccgtcct tatcaatgct 2924761 attgcgagac acgatagcgg ggcttctgtc tttgattgtg ttctgattcc aatgcgaaag 2924821 cgaaatgaat atgaaaatga gctgctgata gccagaaatg aggctcagga agctttgctt 2924881 gccaaacaga aagccaatgc ggagttagaa attgccttgg aaacgctgaa agcaaaacaa 2924941 gaagaacttc ttgagatcaa taaacaaaat caacaattta aattaaacac caaaagagag 2925001 cttgaactcg ccagaaagat ccagaaaaac tcgttgactg aaccgattgt aaacgatcag 2925061 gttcagattg actcttatta caacgcatcg agtgaattgt caggtgatct ttacggatat 2925121 tatcaaatcg atgaacaccg ttacggcatt attatccttg atgtgatggg gcacggaatt 2925181 tcatctgcat tgattacgat gtctcttcat cctttgttcc agcgccagat cacgcaaggt 2925241 ctcagccccg ttaaagttat gaaggaattg gaccggcacc ttcacagctt gtttcaaaat 2925301 gatgaggaag caagacatta ttgcactgct atttatctcg agattgatat agcacggcaa 2925361 agaattgatt atgtcaacgc agggcatccg ccggcacttt ggcaggacga tagcggaact 2925421 caacatctgc ttcacgcgac ctcgcctccg atcgggatgt ttgaagactt agagtttcag 2925481 tcaagcagcc tttcatacac ggaggacgga agattgcttc tgtatacgga tggcgtgatg 2925541 gatcctacgg cttcatgtta tttatttgat ttactaaagg atcatcctga ttcgccaatc 2925601 gctgacctga aggagaaaat ccttacatca ctgcagcatc aaaaggaagc tcatcataag 2925661 agtgatgacg aatgttttat attagttgat gtaaaataaa atgatccatg agacataaca 2925721 atgatttgtt acatctcatg gatttttttg tttcagcgtt tctttggaat atgtcctgac 2925781 tccgcatatt gaaacacctg caaggaaggc agcgggtgtc cattaaaatc aaataaagct 2925841 tgattatcta cagcacttcc cccataccac ttcccggcgt cttcagggtc gtattcagca 2925901 gcatagctgg acgcccaccc tgacccgtat gtttcccata acactttgtt tttctctatc 2925961 tgtgtcttcg gcccgactgg aatccacgcc ggctcccagt agaaaacacc aagtcctgct 2926021 ttgcccgtat tcgccactgc ctccattaca tctcttactg cagttgcctg gccttgaaca 2926081 gaaattggat atggcaacgt ctgcccgctt tttggtgctg tatttccatg cccatcgcca 2926141 tcctcagcgg tataggtgta cgatgtctcc gccaccatga cttttttgcc gtacgtattg 2926201 gcaacagcct tcagcacgga ggtcaaattt tgtaatgtgc catgccagaa aggataatag 2926261 gagctagcaa acacatcata atccactttg tttttgctga gtgtttctgc aataaatgaa 2926321 taccttccag ccgtttcagg attggtaaaa tgcagggcga ccaaaatatt tgaatttgtc 2926381 tccctgaccg ctcggcttcc ttcattaaat aattggcaca tcttcgtcca atcagtctca 2926441 ccggcaaatc ctcctgttgt ttcatttccg acctgaacca tgccgatgtc aacgccttcc 2926501 ttgatcatct tttgcaggct ttgtttcgta tactcataga gctttgcttt ttttgcttca 2926561 aagctgagat tcgcccaggc tttgggcacc ttttgtttcg ctggatcggc ccagaaatca 2926621 gagtagtgaa agtcggccag caccttcatt ccgttcgctg tcgctctttt tccgatttcg 2926681 atggcttttt gaacatcatt gtttcccccg ccatacccgt tgccatttga atcatacggg 2926741 tgattccaga tgcggacgcg aacatagttg accccagcct gttttaaagt tgtaaagata 2926801 tcctggcgtt ttccgtttgt attgtaaaag gtgacaccgc tgttttccaa agcaataacg 2926861 ctggatacat ctgccccttt gataaaatcc ttgttcatcc cctctacttt tttaacaaaa 2926921 agatcctctg cccgaagctc tgacacgtgc ttctccttct caatggcagc ggcatatcct 2926981 gttgaactac atgcactcca cacgatggca gccgcaaaga acattttcac tttgcttttc 2927041 atgatttcat ccccccaaga cttagcaagc gttttcattc tatagaaaaa agaatccgcc 2927101 catatcgagc ggagcatcag cctaatgtgt gtttacgaca attctcactt catacttttc 2927161 catcgtcagg tcgcctgaca atatgtctcc tgtcattatg tccttcacac tctgatcaaa 2927221 cgtgaccagc tgtttttctt ccgtgaaatt catgacaaaa atataatcat tgtcctgatc 2927281 ctgcctcgct tgtacggaga cgccttttcc gtgccgaacc ggaaaaactg gagagagaga 2927341 caggtctgtg atcagaccct catagaaatc acgctgaaat tgatcctcca aacgcgcgcc 2927401 gataaaatac gccttgccct gctgatactc atggcttgtg accgctggcg tgcgcgcata 2927461 aaaatcttct tgatacaccg cttccactga agctgtcttt acatcaatca cggttgcata 2927521 atccttcatt tcatatattt ggctgcggta gctgacagcg tttcgatcct tcggatacag 2927581 ggtgtccgtt tcaagaggct caactccaaa tatagcttga agatccggat gccatccgcc 2927641 tgtgtatgtt aagtcatgct cattcacaac cccgctgata tacgtcatga ctaaggtgcc 2927701 gccgtcagcc gtaaacgctt ttaaacggga aacggtgtcc tcgctgatta aatacagcat 2927761 cgggacgatc agcagtttat atggtgaaaa gtcttgttct ttcgtgatga cgtcgacagg 2927821 gatatcgtgt tcccagaatg tgcggtaatg ctgctgaagc gtttgcggat aacgttttgt 2927881 cgccttcgca aacccctgag catcctcgag cgcccaatga ttttcccagt catataaaat 2927941 cgcggtttga gccggcctct tcgttccgac aacttcggac agccgttcca atgtctcgcc 2928001 taccttggcc acttcttgaa agacgcggtt cttcgggcta ttgtcatgat ccacaaccgc 2928061 tccgtgtaat ttttctgatg acccccgtga tttgcggtat tggaaataga gaacgctgtc 2928121 cgagccgtgg gcaatcattt gcatggatga cagcagattc atgcccgggc gctttgcctt 2928181 gttgacgtta tgccaattga ccgcgcttgg cgtacactcc attaataaga agggctgctg 2928241 cttcaagctt cggtacagat cattgataaa gccgaccttc atcgccaaat cagctgtgct 2928301 ttcccagtca ttgtgccaga caggataagc gtcccagctg atggcatcga catgctttgc 2928361 aaatttgctg tagtcgaggc cctgatacgg gatcaaatcc ggtgtgtcag ccataaaatt 2928421 cgttgtgata gggatatcag gcgtcaattc tttcagcgga atgatttcat tttcataaaa 2928481 cgaaatcgtt tgatcggtga cgaaccggcg ccaatctaaa ttcaggccat gcaagccatt 2928541 ttcaccgatc ggcgaagggc tttcaatttg tgaccagtca ttgaacgtat ggctccaaaa 2928601 aggggtccac cacgcatggt tcaatgtctt gaggctgttg tcatatttcg atttcagcca 2928661 ctcccggaaa gcatgctggc ataaatcaca gtggcaatct cccccgtatt cgtttgaaat 2928721 gtgccacatt aacagcgccg ggtgatgtcc gtatcgttct gctaataagc ggttgatgtg 2928781 ccgtgttttt tctcggtaga ctttagatgt gaggcagtgg ttgtgccttc cgccgtgcag 2928841 ctgtttgacg cgggaggcat tgacgcgcaa aacttccgga taggtttgcg acagccaggc 2928901 cggacgggct ccgctcggcg ttgctaatat gacccggccg cctatactgt gaatccgctc 2928961 aaaaatatca tccagccatt caaattgata tacgccctcc tccggctcaa gtgcgctcca 2929021 tgcaaaaatg ccgacagaaa acgtattcgt atgagaaagc ttcatcagtt tgatatcgtc 2929081 agctaaaata tcgggccgat ccagccactg atcggggttg tagtctcccc catggagcat 2929141 aaattttgct tttgttacgt gcgttttttc aagctttgac atcacattct cctccttgtt 2929201 ctcttagccc ttcgttccgc ctgcggttaa tccggacaca aaattctttt gcagcataat 2929261 aaagatgacg gcaaccggta tgctgataag cagggctccg gccgcaaatg tcgtatagct 2929321 ggcccccatg acatcattca ctaaattgaa tagaccgacg ggcaatgtat atgattcagg 2929381 cgttctcaat atggttgagg acagcacaaa atctccgagc ggaccggtaa agccgttcat 2929441 ggccacgact gccgccatcg gttttgataa tggcagaatg atctggaaga agattctggt 2929501 gctgctggct ccgtcaatct tggcgctttc gtctaaatcc atcggaatgg aatccatgta 2929561 ccctttcatc aaatacgtat tcatcgggat caggccgccg atataaagca agattagcag 2929621 ccagtggcta ttgatcattc ccaagatttg cgccagcaca aacaaggcaa ttaaagctga 2929681 aaactgagga atcatctgca gcaataaaaa gagcgttaaa gcgtatttcc tccctttaaa 2929741 ccgaaagcgc gaaaacgcat aggccgtaaa cgtcacacag agcaaagacc ctgccattgt 2929801 aaacaggctg atcttcatag agttgacata ccactgcaca tattgaaggc tttccttgcc 2929861 cgcaaataat tccttgtaat gatcgaatgt cggatgcttc ggaatgatgg atgtactgat 2929921 taagctgttg ccgggattaa agcttgcgcc tgccgtccaa aggagaggat aaacaatgat 2929981 gaccgccata aaggctagca acaagtaaga gaaaaggaga cggatatatc ttctgacttt 2930041 catatctgcc agcatacctt atgcctcctc tttaaaagac tttgtctgtc tgaactgcca 2930101 caatgcgatg gagataacaa atacagataa taaaatggtt aaagccgcag caagtgaata 2930161 ttggctggac tgcattgtca atttataaat ccatgaaacg aggatatctg tcccgccggc 2930221 tgttgatccg gttacagccg gacctccgcc attgaataga tagataatat taaagttatt 2930281 aaagttaaac gtaaactgag taatgataat cggagccatt gcaatgaaca ccatcggaag 2930341 cgtgatgtat ctcagctttg aaaagacaga agcgccatca atcgtagctg cttcatacag 2930401 atcgtccggg atggattgca atacgcctgt tgagacgaga aagatgtacg gaaatccgag 2930461 ccagccctgc atgagaatca atgcaagcct cgaccaattg gcatctgtca tccacggaag 2930521 cggatctatc ccgaagaaag ccaagatgtc gtgattcatc gcaccgaagc tatcattaaa 2930581 cagtcccgca aaaattaaaa tcgtcacaaa accgggaacg gcccatggca aaatcagaat 2930641 cgtccgaaaa aaacgtttaa accgaaggtc tttctggtta acaatgatcg cgagaaaaat 2930701 ccccaaggtg acttgcagtg tggatgcagc aagtgtccaa accaccgtcc aagccagtac 2930761 atcaaaaaaa gtcgacctcc aaatatcaac tgtgaaaata tttgcgaacg tttgaaaacc 2930821 gacccaatca attaattttg caggaggaga atgatacaaa tcatagtttg taaacgctaa 2930881 tgcaaagctg aataagatag gaaagatcac ggcgaaaatt aaaataaaca aagatgggcc 2930941 gctgacgaca taaggatagc cctcagaaat gatatgctgg tattgttcct ttaaggaact 2931001 taatggctta ttttcatcac gctgttttcc gctttggaac gcatcgcgaa gatttacata 2931061 atacaccgca aggccaaagc aggtcacgat gacagcaata atcccttccg ccagcagaaa 2931121 aacggaatta tcccgcggca cttctgttcc cagtgtaaag attccccaaa accccatatt 2931181 gagcagatct ccaaagaccg caaaaaacga tgcgcctaag aaaagaaaga caataccttt 2931241 tatccattgc ttgttataaa attgcccgag tcccggaatg atagaaagca acaaagcgac 2931301 ttgacgatgc tgcaccgttt tcacctctct tacaatacaa atctagcttt ctctttattt 2931361 tccgctgtgc tttgccttaa tttgtccttt ggccgtttca gctgcttgat ccaatgcttg 2931421 tttcggatct gccttccctg ttgcaaccgt ctgtaatgct gaatcagccg gcgtccatat 2931481 ttcattcatt tccggaatat ttggtgttgg ctctgagaaa cgggattgtt cagtaacagc 2931541 ccgtgccgcc tcgcttttca taatagccgg gtcattggct agggatttca cagcaggaac 2931601 ttctttcgtt tcttcatatc gtgttttaga atttttttca tttgccagga aaacggctaa 2931661 ttcttgcgcc agctcttcat tctttgaaaa tgcactgacg ttgtagcttt tgacgccgat 2931721 aaaggagctc atgtttttcc cattttccag cttcggcagt ttcgtaatgc cataattgat 2931781 tcctgcattc gaaaaggctt ctacattcca tggaccagaa ataattgcgg cggcttttcc 2931841 ttctgtgaac agcgattcca acacgttaat cccttgttct ccaataatgc cagccgggaa 2931901 caggccatct ttgtaaaact tctgaatcag cgccgcacct ttgacagctc cttcattatt 2931961 gattccaatg tctgacgggt tatagctccc atctttggcc tttccaaaaa tgtatccgcc 2932021 atatccgctc atcacacttt ctgcataata aatttgatcg aatagggcta aaaagccaaa 2932081 tttgctgccg tcagcagtct ttttggaata gtcgtaccac tcttccagcg ttttgggcaa 2932141 ttccttttct gtgatgagat ctttgttgta aaaaagcaca gtcgtttcga ccgcttttgg 2932201 cagtccataa agcttttgat ctaccatttg agactgaatg gaagcgtcag tataaagtga 2932261 ttgaacgtct tttttgacat gtaattcctt gagtaatcct tccgtgacag cggttccgat 2932321 ttggtcccct ggcattgtta acacgtcagg gcctgtgccg gccggtccat ccattcgcaa 2932381 atcttcaatc tgcttggcat acggtttttc aacgactttg accttcacat catgctcttt 2932441 ttcaaatgca gccacagcgt ctttaatgcc gttgctcttt tctttatcct cccatacaac 2932501 aagctctgac ccttttgaac tcgatttggc gctgctgctt tcctttgggc cgcaagccgc 2932561 caaggataaa ctgacagctg cgcagagcat gaatacggaa cacttttttg ccattttcat 2932621 tgattgtcac cctttcggta ggaatgaaag cgctttaaag ataatatagc atgcctgaga 2932681 aaatgtgtaa acaaactatt tacttcatag agtaaatttt tttacctaaa taaaaaatga 2932741 cttagtgtcc taagtcatcc ttaattcata ctcttcctga cgattaattc tgcgcccaca 2932801 tataatgttt ttaccgttct tctcttgtcc tgcacttgtt caagcagtaa ttgaacagcg 2932861 tttttacata attcatgtat atcaatatga aacgtcgtca gaggaggcga gacatacttc 2932921 gcgaagctga tgttgttgat actcacaatg cttaccctgt ttggtatggc aattcctttt 2932981 tcgttcaggg cttgcagaca gcccactgca atcgggtccg ctgcaatcat aaaagcagtc 2933041 ggaagctgat cgcctaatgt gtcgatcgct gctgacatca ggcggtagcc gttttctaca 2933101 gagaatccgc gatgacagaa aatatagcgc tcgtccagca tggctttttc cctcatatag 2933161 gatctgaagg tttgttcacg gatgtccatt tcatcctgat tggtattcgg atttttgtat 2933221 gtgccgccga taaaaccgat gctcttatgc cccttctcag tcaggatgtt taccgtcttc 2933281 cttgtcattt gtgccaaatc gggccttacc gagtcaaaat gatcgggatc aggagttgaa 2933341 tcgatgaaca cgccgttttc agtgagattt ctgaggaaag ccagctcttc atctgaaaat 2933401 gtgccgacgg caataaaccc ttccgtatgt tcaggaatgc tctcgattcc atccgctatt 2933461 ttataagtgg tcatatcgac attgaatgct ttcgccagtt tctctacttc taatctcatc 2933521 gttttaaaat agacatcttc taattcttct ttatctgtca gccaatataa aaacgcaata 2933581 tgtttcacca gcggccttac tgtttttttg cggtaattga gcttttccgc cgcttcatag 2933641 attttctccc gtgtctcatc aggaacagaa aggctttcat cgttatttaa aacgcgggaa 2933701 acggttgaga ttgaaaatcc cgcttcctgc gcgatatctt taattgtcgc cattgtatct 2933761 gcctccatta ttcagctcgc attgttttag taaaatattt tactttcttt ttcacaaatg 2933821 tcaagtgcac aaagccctct ggctgccatg taaaaagact gaaccatttg cggctcagtc 2933881 tcagttgttc gtatcattcg gaaccggcgg aattgcccgg gaaatgagtt ggttattgca 2933941 cattttcctc gaaatatccc gaaagcacat cttccacatt cgtcaaatgc gccagcatgg 2934001 cggcttccgc ctgtgcaccg ttcccggcag ccacagcatt gtaaatccgt tcgtgctcct 2934061 catacagccg ctgaacggag gtcttcttgg aaaacagcca gattttcctc gtttccctca 2934121 ttgtttccag cagcaatgat gacacgtgat tcatcaagtg tttaagaagt tcattttgag 2934181 aagcgtccgc aagcgcaaga tgaaatgcaa agtctgcttt ctctcccagc tccccgtccg 2934241 cttcaatgct gcccatttcc tttagtgcat cctgaattct ttcgagatct gcttctgtcc 2934301 ttttttcagc cgctagtgaa gccacgccga tttcaagcag ttttctgacc tcgagcagct 2934361 gcttgacgtc ctcttttttc atcagaaggg cggctgagag cggctgagaa atttgattga 2934421 gctcaaattc cttcagatac gtgccttctc cctgtttcat ttcgacaagc cccatcgctt 2934481 ttagcgcaga aagtgcttcg cgaaccgctg aacggctgac ttgaaagctc tcagcaagcg 2934541 cctgaacaga gtccagttta tcccccggct tcaattcgcc atttttgatc atatctaata 2934601 gggcatccgc tacttcttca tatatttttt tgttttaatc tgtttatatt tcaatgcaat 2934661 tcaccccgta acttgtaggt ctggctgttt acgatctatt atactctgtt ttgtgggccg 2934721 ccaaaagatt ttgactattt tgtcaaaaag tcttgtactt tgattttttt caaaatataa 2934781 tgctaggtaa ctggtcttat tacccagtca tcagatgatc atatcatcta tagaaaccgc 2934841 ttacatatgg cgccagttta tgtttcaagg aggggtttgg gatgcaatgg acacaggcat 2934901 atacgcctat agggggaaat ttgctattat cagcgcttgc cgcacttgta ccgattattt 2934961 tctttttttg ggcactcgcg attaaacgga tgaaggggta tacagcaggc ttggccacat 2935021 tggggatcgc ccttatcatt gctgtattgg tttatcgtat gccggcggaa aaagcgctga 2935081 tgtccgcgac acaaggagcc gtatacggat tgttgccgat cggctggatc attgtgacgt 2935141 ctgttttttt gtataaaatc actgtgaaaa cgggacagtt tgatatcatt cgcagctctg 2935201 ttctctcgat tactgatgac cgacggcttc aagctctctt gatcgctttt tcattcgggg 2935261 cttttttaga aggggcagca ggcttcggag cgccggtcgc catttctgcc gcgctgctgg 2935321 tcggtctcgg ctttaatcct ctttatgctg cggggatctg tttgatcgcc aatacggcgc 2935381 cggttgcctt tggggcaatt gggattccaa ttacagccgt agaagggccg acagggattc 2935441 cggcgatgga gatttcgcaa atggttgggc ggcagctgcc gtttttatcc gtatttattc 2935501 ctctttattt aatcatcatc atgagcgggt tcaggaaagc cttggagatc tggccggcga 2935561 ttctcgtatc cggtgtttcc tttgctgttg ttcaatatct cagttccaat tttttagggc 2935621 ctgagctgcc cgatgttttg tcagctcttg tttcaatggc tgcgcttgct gtgtttttga 2935681 aatggtggaa gccgaaaaca acattccggt ttgccggtga acaagagtcg gccgcctcaa 2935741 ttgaaacggc gcgcacaaat ccggcggcgc ctgcatacag aggcggacag atttttaagg 2935801 cttggtcgcc atttctgctg ctgacggcga tgatttccgt atggggcatt ccatctgtca 2935861 aatccgcgct gaccgggcat tatgaaggct ctgcggtgtt cttgaagtgg ctgaatgctg 2935921 ttggagaaaa actgactttt tcccccggtg tgcctttttt gaacaatcag attgtcaatg 2935981 ctgacggtac gccgattgaa gcggtttaca agttggaggt gcttggttcg gccggcaccg 2936041 cgatattgat tgccgcagtg ctgtcaaaat tcatcacggc gatttcgtgg aaagactggg 2936101 gaaccgtttt taaagaaaca gtccaggaat tgaagcttcc gattttgacc attgcttctg 2936161 tcgttggttt tgcctatgtc accaactcct cgggaatgag cacgacactc gggatgacac 2936221 tcgcgctgac aggttcgatg tttaccttct tttcgcccgt tctcggctgg ctcggcgtct 2936281 tcattaccgg ctcggatact tctgccaacc tgctgttcgg caacctgcag aaagtcaccg 2936341 cattatcagt cggcatggac cccgttctgt ctgtggccgc caactcttca ggcggtgtca 2936401 caggaaaaat gatttcaccg cagtcgatag cggtggcgtg cgccgcggta ggactcgccg 2936461 gaaaggagtc agatcttttc cgctttacca ttaaacacag tctgtttttg ctgctgctcg 2936521 tctgtatcat cacctttttg cagcatcacg tattcagctg gatgattcct taaaaaaatc 2936581 ctcccgtcta gggaggattt tatttatatc gctttctcgc tgccgatgac ggaatattca 2936641 tttgatcgcg atattttgcc acggtgcgtc tcgagatttg gatgccgtgt tgttcataca 2936701 gcaaatcgac aagcttttgg tctgaaagcg gttttgtttt gtcctcttga ttgatcaggt 2936761 tttccagatg cgttttgact gcataattcg acgcatctcc atcacctgaa gcctcggctt 2936821 ttgctgagaa aaagagtttc atctcaaaca gcccgtaagg cgtttgtatt gttttccctt 2936881 taatggcccg gctcacagtt gattcatgaa ggcttagaca gtctgccacc tctctgagag 2936941 tcagcggctt cattgcgctt cgccctttca gaaagaaatc cttttggcgt gtgatcagtt 2937001 cattgataat tctcgtgatt gtctgttttc gctgccgcag cgcgcggctc agccagcgcc 2937061 actcctgata tttcgcagat aaataggaga cagtatcctg acaggagccg gatgataaaa 2937121 gcgttctgta ctgcggatgc agatcgatct cgggaaacga gcgggtattc agttccgctg 2937181 cgatgtgccc attttttacg gtgataaaaa tgtcaggctc aatatacaca tcttgctctg 2937241 gccgggcaaa cagaaggcca ggtctaggat gaagagccgc gatatcatct gagatatctt 2937301 gaatggtatg aagcggaatt cccgtctcta ctgaaagcgt tttccatttt ttttgcgcaa 2937361 aagcatcaaa atgagctgaa accagcattt ccgcttgttc atttctgttc ggcagccgct 2937421 gtaattgaag aaggatgcat tcctgcaaag atctcgcgcc gattccagcc ggttctaacg 2937481 actggagttt tgccaaaaca gcctccgctt ccttggccga tacagataat cgccgtgctg 2937541 cctcctctat atcttcttcc aagtacccgt ttgaatcaag cgaatgaatc agataattaa 2937601 aaatcttttt ttcagtgttt gtcagattca tatcgagtga ctgctgtttt aacgcatcct 2937661 gcaatgtttt ttgcggatta cttaattgaa ggcccgcttc ctgtgcattc atcctgtttt 2937721 tgtttgtttt atggtaagat agtggcggtg tgtctgtttc ctttcgttca ataagagggt 2937781 tttccagtga gagctcatca atgtactcgg cgagttctgc cgaatgatag ccaagcagcg 2937841 tgatggcctg cctgagctcc tgtgtcagtt gaggctttaa tacttgtact tgctgaagtt 2937901 tcatatccat cttgctcact cccctttctt cattgtacat gattgagatc acaccgtata 2937961 catttatgaa aaaggagctg ccaaagaaat gtctgaactt ttttccgtcc cttattttat 2938021 tgagaattta aaacagcata ttgaaatgaa tcagtctgag gataaaatcc acgcgatgaa 2938081 cagctactac cgttccgtcg tctcaacact agtgcaggac cagctgacga aaaacgcagt 2938141 tgtcctgaaa cggattcagc atttagatga agcatacaac aaagtcaaac gtggagaatc 2938201 aaaataaacc ttccgaattc gggaagatga tgatcggtta aagggctaac gttcgcatct 2938261 ataggggaaa tctgtttata atgggggaaa aagggagaga acacaatgac tcatcaaata 2938321 gtaacgactc aatacggcaa agtaaaaggc acaacggaaa acggcgtaca taagtggaaa 2938381 ggcatcccct atgccaagcc gcctgtcgga caatggcgtt ttaaagcacc tgagccgcct 2938441 gaagtgtggg aagatgtgct tgatgccaca gcgtacggct ctatttgccc gcagccgtct 2938501 gatttgctgt cactttcgta tactgagctg ccccgccagt ccgaggattg cttgtatgtc 2938561 aatgtatttg cgcctgacac cccaagtaaa aatcttcctg tcatggtgtg gattcacgga 2938621 ggcgcttttt atctaggagc gggcagtgag ccattgtatg acggatcaaa acttgcggca 2938681 cagggagaag tcattgtcgt tacattgaac tatcggctgg ggccgtttgg ctttttgcac 2938741 ttgtcttcat ttaatgaggc gtattctgat aaccttgggc ttttagacca agccgccgcg 2938801 ctgaaatggg tgcgagagaa tatttcagcg tttggcggtg atcccgataa cgtaacagta 2938861 tttggagaat ccgccggcgg gatgagcatt gccgcgctgc ttgctatgcc tgcggcaaaa 2938921 ggcctgttcc agaaagcaat catggaaagc ggcgcttctc gaacgatgac gaaagaacaa 2938981 gcggcgagca cctcggcagc ctttttacag gtccttggga ttaacgaggg ccaactggat 2939041 aaattgcata cggtttctgc ggaagatttg ctaaaagcgg ctgatcagct tcggattgca 2939101 gaaaaagaaa atatctttca gctgttcttc cagcccgccc ttgatccgaa aacgctgcct 2939161 gaagaaccag aaaaagcgat cgcagaaggg gctgcttccg gtattccgct attaattgga 2939221 acaacccgtg atgaaggata tttatttttc accccggatt cagacgttca ttctcaggaa 2939281 acgcttgatg cagcgctcga gtatttacta gggaagccgc tggcagagaa agttgccgat 2939341 ttgtatccgc gttctctgga aagccaaatt catatgatga ctgatttatt attttggcgc 2939401 cctgccgtcg cctatgcatc cgcacagtct cattacgccc ctgtctggat gtacaggttc 2939461 gattggcacc cgaagaagcc gccgtacaat aaagcgtttc acgcattaga gcttcctttt 2939521 gtctttggaa atctggacgg attggaacga atggcaaaag cggagattac ggatgaggtg 2939581 aaacagcttt ctcacacgat acaatcagcg tggatcacgt tcgccaaaac aggaaaccca 2939641 agcaccgaag ctgtgaattg gcctgcgtat catgaagaaa cgagagagac gctgatttta 2939701 gactcagaga ttacgatcga aaacgatccc gaatctgaaa aaaggcagaa gctattccct 2939761 tcaaaaggag aataaatatg gggaaaacag gatacattgg tgctgccatt gttgtggcag 2939821 cttgtatcat tattttgtcg gccgtggtat gtttacggga cacagtctat taccagccta 2939881 tgcgctggac tggcatcata ctgtttttcg cgggaattgt gatggttccc gcatactcag 2939941 caaaaagaaa acccggaaaa gagaagtaat tctcttttcc gggtttttat gtttattata 2940001 atcttcccgc gcgaatatcg tctgtcattc cctcataagg agccttcgaa atcacttctt 2940061 cgttgtcgac tccttcattt ttcagaaatg taatttccgc aaattcaggt acaacgtatt 2940121 ttggatacgt ttcatatttt tcgcgggatt ctttcatcaa atcaatgtgg tcattttggt 2940181 agcaaaccgt aatttcagga tgttcatgca cccatttcgg gaagaaaata atgccatgca 2940241 tgcgtttttc atttggcata aagtttaatg aaacatccgt gccagtcggc tctgtccaag 2940301 acactttata tacgccttct gtcagtttga caatattcac ttcctgatct cgaacccagc 2940361 gtccggcaac cattccgcta tgaattctat aatcaattgt atggtcgttt ttaatataaa 2940421 tctcgtattc ccatccgttt tcatacgtat aaatcatgtg gcttccgata aagttttcca 2940481 tcttacacac tctccttagt cttttactgt acttcataaa tgtctagtag aacgtaatca 2940541 ggggttcttt ctgcggaacc gataaacaag cggtcatgga gccattgata gacttcactg 2940601 cctgtttcaa acgtcggtac cgtacgaaaa taaacatgct ccggttcaat aatttccccg 2940661 gctgccgctt gttttcgaaa cggcttgctg acttgccgta ttccattgtt ttcaatgtaa 2940721 atcagttcat gatctgctgt ttcaatcaca tacctggcag ataaatctgt tctgccgtta 2940781 gcgcgaatca tttgtgaatc ggcaccgccc ggcaaaatac gtccctttac ttccccggtt 2940841 attgttcccg aacgaatcgg aatgaatcat ctcagtccca ggcttgtctc accaatcgtg 2940901 ataggcggat caaccttgat ttctaaagag gcgaatggtt ttaaaaccgg cttcttcacg 2940961 agaaccacct caccttcaga aaaaatcatg taactattta catgttcact ttaacaccat 2941021 tgcagttaac tgtcaaacaa taggaacata aaaaaacaag gactgtttga agacagtcct 2941081 tgtctgaagc tagctttgat aagcaagata tgtgctgaca gtgcttttgg caagacaggc 2941141 agaggaatct ataatcggaa tctcactttg aatatgatct aacaccgcat ttaaatccgt 2941201 gcaggctgaa atgatgatgt ctgcatgctg actgatttct tcatatagcg tctgccacaa 2941261 tgcttgtgta tgctgcatat gatttggctg tttgattgcg gcgataagct ggttcacagc 2941321 ctgctgccaa tggtccttgt gaataacttc ttgtccattt cccttcagaa ctttttggta 2941381 gatggcggat tggatggttg gctctgttcc taaaaccacc gctttttttg cgggatgcgg 2941441 aatctctttt atcgtttcct caacaatatg caacatagga actgacaatg cctgctgaat 2941501 ctcttcatag tagacatgcg ccgtattaca aggcagcgca atgaaatcca cgcctgtttt 2941561 ctcgagcttt accgctccgt cgataatcgc ttttttcatc tcgtcatggt caattggacg 2941621 atctgcatag aagggcgtcg ggcatgaata gatcatcatg tgcggatagt caatatcgtt 2941681 tgaagcccca tacagcttct gacagtaatc aatcacctta tcaataaacg gcgaggtcga 2941741 tttcggcccc attccggcta atattccgat catcaaattc attcctttct acttcgtacg 2941801 gaccgcttct tcctctgagc catcctcata gaggataaag cttttcgcag catcctcacc 2941861 taatgtaaac tcgacttcaa cagacaatgc tcgcagaaag aaacgggttt ccgaggaagg 2941921 aaataactcc agtctcagct gtccggcgat ctccaaataa agccgttcat tctcggttgt 2941981 cacctgtgca gccgtcccat cctgcaacag gtagctgcca acatagcggc tgtatatcgc 2942041 cgtatcaatt gcttttttct ttttatcagc aggacgttcc gggacatcat atggctggcc 2942101 aaatagaata tgttccgccg ccttcagaat cgcttgttca tattcagtat cctcttcctt 2942161 attactcaaa tagatcagcg ttttacgatg atcgatatat cggatcatca tcgtcgaata 2942221 gccgggccat cctccgctgt ggctgacaat ccgccctttt tcaggactgt tttgcagcac 2942281 ccagccaaag ccataatcaa ttgtttctcc attgttgagg cgcactggag aaaacgcaga 2942341 ttccttagaa gccttgctga tgaaatcgtc ctgatataaa gcctgatcaa atcgaaacaa 2942401 atcgcttgtg acagagttaa ccgtcccatc tccctgtatg ccatcgagat acacaacata 2942461 gttcgtttcc tccagctcat cagggaggac gtatgtttcg gaatgtacat catacacata 2942521 tccatatgca taatgatcaa ttcgctcagg cgaaagcctc ctgttataca ctcttgtttc 2942581 attcatgcct gccggtaaaa aaatacttgt ttttataaaa tccgcatagc tcatgccaga 2942641 tgctttttca atgataaccg ccagcagcac ataccccgta ttgctgtaca tccagccttc 2942701 attcggttca aaataaccag atagcccctc attcatcagc atatcgacaa tatcctgatt 2942761 caccgcaatc ttgtgtgaat cccaattggc aaaaaaccat cccatataat caggaagccc 2942821 tgacgtatgg ttcaataaat gccgaatcgt tacgccctga tacggaaaac cgggcagcca 2942881 gcgatccact ttatcctcat agccaagaat ccccttctcc tccagcaaga tgattcccaa 2942941 tgctgtaaaa ggctttgaca aagacgctaa ctcaaacaaa gagttggttt tcaacgggcg 2943001 tttttccgtc atttccgcat agccaaaaga gtggtgatat aaaatatcgc caccctccgc 2943061 agccagaacc gtcccgttaa actgatgttt ttcgcctaat gtctcaaata acgtctgaag 2943121 atgctttctt ttattctgct tcattcctcc acctcccata tctctgtacg ttactaacct 2943181 actaacgttt caaatatttt gaaaaatcct tcagttagag atccttttta acccatcaca 2943241 tatacctgcc gttcactatt atttagtgaa atgagatatt atgatatttt ctgaattgtg 2943301 attaaaaagg caactttatg cccatgcaac agaaactata aaaaatacag agaatgaaaa 2943361 gaaacagata gattttttag ttctttaggc ccgtagtctg caaatccttt tatgattttc 2943421 tatcaaacaa aagaggaaaa tagaccagtt gcaatccaaa cgagagtcta atagaatgag 2943481 gtcgaaaagt aaatcgcgcg ggtttgttac tgataaagca ggcaagacct aaaatgtgta 2943541 aagggcaaag tgtatacttt ggcgtcaccc cttacatatt ttaggtcttt ttttattgtg 2943601 cgtaactaac ttgccatctt caaacaggag ggctggaaga agcagaccgc taacacagta 2943661 cataaaaaag gagacatgaa cgatgaacat caaaaagttt gcaaaacaag caacagtatt 2943721 aacctttact accgcactgc tggcaggagg cgcaactcaa gcgtttgcga aagaaacgaa 2943781 ccaaaagcca tataaggaaa catacggcat ttcccatatt acacgccatg atatgctgca 2943841 aatccctgaa cagcaaaaaa atgaaaaata tcaagttcct gaattcgatt cgtccacaat 2943901 taaaaatatc tcttctgcaa aaggcctgga cgtttgggac agctggccat tacaaaacgc 2943961 tgacggcact gtcgcaaact atcacggcta ccacatcgtc tttgcattag ccggagatcc 2944021 taaaaatgcg gatgacacat cgatttacat gttctatcaa aaagtcggcg aaacttctat 2944081 tgacagctgg aaaaacgctg gccgcgtctt taaagacagc gacaaattcg atgcaaatga 2944141 ttctatccta aaagaccaaa cacaagaatg gtcaggttca gccacattta catctgacgg 2944201 aaaaatccgt ttattctaca ctgatttctc cggtaaacat tacggcaaac aaacactgac 2944261 aactgcacaa gttaacgtat cagcatcaga cagctctttg aacatcaacg gtgtagagga 2944321 ttataaatca atctttgacg gtgacggaaa aacgtatcaa aatgtacagc agttcatcga 2944381 tgaaggcaac tacagctcag gcgacaacca tacgctgaga gatcctcact acgtagaaga 2944441 taaaggccac aaatacttag tatttgaagc aaacactgga actgaagatg gctaccaagg 2944501 cgaagaatct ttatttaaca aagcatacta tggcaaaagc acatcattct tccgtcaaga 2944561 aagtcaaaaa cttctgcaaa gcgataaaaa acgcacggct gagttagcaa acggcgctct 2944621 cggtatgatt gagctaaacg atgattacac actgaaaaaa gtgatgaaac cgctgattgc 2944681 atctaacaca gtaacagatg aaattgaacg cgcgaacgtc tttaaaatga acggcaaatg 2944741 gtacctgttc actgactccc gcggatcaaa aatgacgatt gacggcatta cgtctaacga 2944801 tatttacatg cttggttatg tttctaattc tttaactggc ccatacaagc cgctgaacaa 2944861 aactggcctt gtgttaaaaa tggatcttga tcctaacgat gtaaccttta cttactcaca 2944921 cttcgctgta cctcaagcga aaggaaacaa tgtcgtgatt acaagctata tgacaaacag 2944981 aggattctac gcagacaaac aatcaacgtt tgcgccaagc ttcctgctga acatcaaagg 2945041 caagaaaaca tctgttgtca aagacagcat ccttgaacaa ggacaattaa cagttaacaa 2945101 ataaaaacgc aaaagaaaat gccgatatcc tattggcatt ttcttttatt tcttatcaac 2945161 ataaaggtga atcccatatg aactatataa aagcaggcaa atggctaacc gtattcctaa 2945221 cctttttagg aatattgctg tttatcgact tatttccaaa agaagaacat gaccaaaaaa 2945281 caaaatcaaa acagaagccg gactaccggg cggcatatca ttttacgacg ccggataaat 2945341 ggaaaaatga ccctcaaaaa ccgatctatt ttgatggcaa gtatcattat ttctatctat 2945401 ataaccggga ttacccaaaa ggcaacggca cagaatggcg ccatgccgtc tcagaggatt 2945461 tggtgcactg gaccgatgaa ggcgtggcga ttccgaaata tacaaacccg gacggtgata 2945521 tttggaccgg ttccgtcgtg gtggataaag agaacacagc cggcttcggg aaaaatgcgc 2945581 ttgtcgcgat tgtgacacag ccctcagcca aagacaaaaa acaggaacaa tatttgtggt 2945641 acagcacaga taagggaaaa tcattcaaat tctacagtgg caaccccgtt atgcctaatc 2945701 cgggcacaga cgatttcaga gatccgaaag tcatatggga tgaccaagat aacaaatggg 2945761 tcatggtcat ggctgaagga tcaaaaatcg gcttttatga atccgataat cttaaggact 2945821 ggcattacac aagcggattc ttcccagaac aggcgggaat ggtggaatgt cccgacctct 2945881 acatgatgcg ggcaagcgac ggaacgaata agtgggttct cggtgccagc gcgaatggca 2945941 aaccgtgggg caaaccaaat acgtacgcct actggaccgg aagcttcgac ggaaaagaat 2946001 tcaaagcgga tcagactgaa gcccaatggc ttgactatgg cttcgactgg tatggcggtg 2946061 tgacgttcga agacagcaaa agcacagatc cattagaaaa gcggtatgcg cttgcctgga 2946121 tgaacaattg ggattatgcc aacaacaccc cgacaatgaa gaacggcttt aacggcacag 2946181 attctgtcat acgcgaactc cggctgaagg agcaggatgg aacatacagc ctcgtctcac 2946241 agccgattga agctttggag cagctgactg tttcaactga cgaaatagag gatcaggatg 2946301 tgaacggatc aaaaacattg tcgataacag gtgatacgta ccagcttgat acggatcttt 2946361 cttggtcaga gctaaagaat gcaggcgtca ggctcagaga atcagaagac caaaaacgcc 2946421 atattgatgt cggcattttc gctgaaggcg gctatgctta tgtcaataga gcagccacaa 2946481 atcagcctga caaaagcaat acctatgtcg aaagcaaagc tccttatgat gtaaacaaac 2946541 gtaaggtgca tttgaaaata cttgtcgata aaacaacgat agaagtattt gttggcgacg 2946601 ggaaaaccgt tttttcaaat gaagtcttcc caaagcctga agataaagga attacccttt 2946661 attctgacgg cggcacagcc tccttcaaaa atataacagt gaaacacttt gattcgattc 2946721 atgaataaaa acaggggcgg cgcaggctgc ccctgttttt ttattaggag cggtattctc 2946781 tgttacatat tgggcattgt aaggaatata aggctggttt caaaggagga agcgaatgtc 2946841 taaacaagga aattttcaaa aatcaatgtc gctgtttgat ctgattttga ttgggatggg 2946901 agccatcttt ggatcagcgt ggctgttcgc tgtcagtaat gtcgcttcaa aagcagggcc 2946961 ctccggcgct ttttcctgga tcctcggagg agccattatt ttgttaatcg ggcttgtata 2947021 tgcggagctc ggagccgctc tgccccgtac cggaggcatc attcgatacc ccgtttattc 2947081 acatggccac cttgtcggct acttaatttc gtttgtcacg attgtcgctt atacaagctt 2947141 gatttcaatt gaagtgacag ctgtgcgcca gtatgtggcc tattggtttc ccggcctgac 2947201 cattaaaggg tctgattcgc ctaccatttc cggctggatc ttgcagtttg ccctattatg 2947261 cttgtttttc ctgctgaatt attggagcgt caaaaccttc gctaaggcga atttcatcat 2947321 atcgattttt aaatatattg tgccgattac catcattatt gtgctgatct ttcattttca 2947381 gccggagaat ttatccgttc aaggatttgc accgtttgga tttacaggta ttcaggctgc 2947441 catctcgaca ggcggcgtca tgtttgcgta tctcggcctg catccgattg tatctgtagc 2947501 aggtgaagtc caaaatccaa aacgcaatat cccgatcgct ttaatcattt gcatcatcgt 2947561 ttcaaccatc atttatactg ttttgcaggt cacctttatt ggtgcaatcc cgacagaaac 2947621 actgaaacat ggctggccgg caattggccg ggagttctca ttgccgttta aggatattgc 2947681 ggtcatgctc gggttaggct ggcttgcaac gcttgtcatt ttagacgcca ttctgtctcc 2947741 cggaggaaac gggaatatct ttatgaatac gacatcccgc cttgtttacg cctgggcgcg 2947801 taacggcaca ttatttggca tattctcaaa ggtcaataaa gatacgggga caccccgcgc 2947861 ttcgctttgg ctttcgtttg ccctgtccat tttctggaca cttccctttc cttcgtggaa 2947921 cgcgctcgtc aatgtctgtt cagtcgcgct cattctttca tatgcgattg cacccatttc 2947981 ttcagctgcg ctgagggtca acgcgaagga cttaaacagg ccgttttatt taaagggaat 2948041 gagcattatc gggccgcttt cctttatatt tacagcgttt atcgtgtact ggtcaggatg 2948101 gaaaacagtc tcctggctgc tcggttcaca actcgtgatg tttttgatct atctctgttt 2948161 cagcaaatat acgcctaaag aagatgtcag ccttgctcag cagctgaaat cagcctggtg 2948221 gcttatcggg ttttatatta tgatgctgat cttttcctac atcggttctt tcggacatgg 2948281 tttagggatt atcagcaatc ccgtcgacct cattttagtc gcgatcggct cacttgcgat 2948341 ttattactgg gcaaagtata ccgggctccc aaaagccgcc attgattatg ataaataaag 2948401 aagcaagagg ttttcttgct tctttattct ttacaaacaa acatacacgc gataaaatga 2948461 atgagagtca gtcattactg gaggtgttcc tcatgccaaa acaaacatcg ggtaaatacg 2948521 aaaaaatatt gcaggcggcc atagaagtca tttctgaaaa aggcctcgac aaagcttcta 2948581 tttctgatat tgtcaaaaag gccggcactg cccaaggaac attctatttg tatttttcat 2948641 ctaaaaatgc cctcataccg gccattgcag aaaatctcct cacccataca cttgatcaaa 2948701 tcaaaggtag gctccatggg gacgaggatt tttggaccgt tttagatata ttaattgatg 2948761 agacatttct cattacagaa cgccataagg atattattgt cctctgttat tccgggcttg 2948821 cgatcgacca ctccatggaa aaatgggaga cgatctatca gccttattat tcctggcttg 2948881 aaaaaatcat caacaaggcc attgcaaacc atgaggtaac ggaaggaatc aattcaaaat 2948941 ggacggccag aacgattatc aacttggtcg agaatactgc ggaacgattc tatatcggat 2949001 ttgaacaaga tgaaaatgtt gaagtgtata aaaaggaaat tttcactttc ttaaaacgga 2949061 gcttaggtac tgcttaaaaa atgactgggt aacaccgctc attttttaat gccctaaaaa 2949121 tgactgacgt tcattcataa aatagagagg tgtttcattt gaattgggtt cttgttttta 2949181 ttgcagggct tttagaggtt gtttgggcct cttccctcaa acatgccgat tcgcttttgg 2949241 attggatcat catttttatc ttaatcgcgg tcagctttat cctgttgatc cgctcttatc 2949301 aaaaaatccc gatggccgcg gcgtacactg tgtttgtggg aatcggaacc gtcggaacat 2949361 atctgactgg aattgttctg ggcgaatcct tctcagcagc ccaaatgttc tttttagctt 2949421 tattgctggc tggcatttta ggaatgaaat tatttacgaa agaaagcaaa tctcagccgg 2949481 gaggtgaaaa ataatggcat ggtttttatt agtgattgcc ggcatagaag aaattatagc 2949541 tgccattgcc atgaaatata tagacggaac aagaaaaaaa tggccgatca ttgtgatgac 2949601 tgttggattc ggcttatcct tttactgcct gtcccaagcg atgatcgtcc tgcctgccgg 2949661 agtcgcatat gccgtctgga ctggcattgg aagcattggt gtttcggcgg tcgggctcat 2949721 ctggtttaag gagcggtttc agctttcaca ggtgatttca ctttgcctta tcctagccgg 2949781 cgtcatcggc ctgcgtctta cgtcatcttc ataaaatcaa ggcatataca gctgtatatg 2949841 cctttgccat taagcttcgt gatgtttttg aagatgaagc ggcggcggga tgagccagcc 2949901 tttgtttttt agcagcctta agtattttgc gccggttgcc gctttcgaca tatgaaattg 2949961 cccaaacatc atggcaatat cctcacgaat cgattgcccc atcattttgc tgcatgtcac 2950021 aagacctgca gcattttctg ctgccgcgga agccgccaca tccggatcga gaaaccgtgc 2950081 accaggcgga atatcgttaa gatctgctgt cggcggttca ggagaagccg gcggcagcgc 2950141 caccccgttt tctttcagga tcgtgctgac ctgtttgatt tcatcttggc atttctcaat 2950201 agactcacga agcagcttct tcaggtcgtc atcaccgaca tgattcaata gcatttggta 2950261 attgccgacc attttattgc ccgccatcac ataactccac aagccgaata cctcaccgta 2950321 atgcatcggt tcatcctgcg gatttccgct taaaataccc atgctcattc tcctcccata 2950381 ttcaatattg cacatttcat aacgtgccca agcggaggaa catttatgtt tcagcggaaa 2950441 agatttatga aatgaaacaa aacaaaaaag acaagagtgg caagttgcca aaccattgtc 2950501 tttcctgttg tttgattgga cgcactgaag ggattcgcac cccgacagac aagataccgg 2950561 aaaccattca agtgcttttt agtatgagtc attgattctg tctttaataa actttaacga 2950621 gatggcggga tgctttgcgg aaaacgaaat acattttcgg ggtcatattt cgcctttatt 2950681 tctcgaagcc gcgcaaagtt tgcgccataa tattcttttc cgaagttttc aatgttttga 2950741 tctggaacat taacatatga acctgctaca tatggttgca tcagctgacg cactctttca 2950801 actgatgcaa gatttgaatc ttcttgtgat ttatttttcc aactagccgt ccattccgta 2950861 taaaataatg gatggcgcca aaaaaaggca gtttcgtctt tagggactct gcttatagca 2950921 ccaccccaat tgataaaaaa gaaattggct tctgttccag tagcatcttc caaaaatttt 2950981 ctcatgattg aaatgggttc gtcagaccaa aaatcatgac cccatgccga ggagaattta 2951041 acactctgat catttctgcc agggatgggt tcgtcagggt ctaagaaatc tatagcatct 2951101 ggatagtata atgttttgat atctgcttct gttggagttc ccgcatgtaa taaaggtttt 2951161 aataatcgaa tcaattcagt tttcgaaccg aggaaaattc cttctgcatg acacaaacca 2951221 tttattttgc tgtaaatttc aaggtagcat cctaatcgtt catctacaaa cggagcccat 2951281 ttctgccaag ctttaaatac cgtttctaat tgttcccacg gccagataat attgaagacg 2951341 gttgcagttt taggggcacg atgaactttg aatgtatatt gggtattata tccaaagtta 2951401 cctcctcctc cgcctctaga agcccatagc aaatcctcat tgtgagattg atctgcgtga 2951461 ataatccttc cttttgcatc taccgttttc agcgcgagaa ggttatcact tataaggcca 2951521 atcgatcgtg agagtacacc aaatccgccg cccatcgtaa ttcccccgat tccaactgtt 2951581 gggctatctc caaacggagc cataaaaccg tctcgagcta atccctttac aagcgggcca 2951641 acgggaatac cagtttgaac ggttgcaata gcgttttctt catctaagaa aactttattc 2951701 atgtcactca catcaataac aattcctcca cttactactg aaaggttctt atctaaagca 2951761 tggcgaccgc ttctgacacg taagggcact ttattctcac gagcccattt aatggcatta 2951821 cttacatcgt atgaattttg cgcaaaaaca aagacaagag gatagacatc cacataaggg 2951881 ttccaattct taatagcctc tgtatagccg gggtctcctt tgaagattac acgccctgtc 2951941 aactgtgttg atcccatata ttatttcact cccaaagaaa ttcgattcag atactaaaat 2952001 atgcaggagc tggataatcg catagacaaa tgatctacga actataaata taatacgcta 2952061 aggccttttt cgtcggtgag gtctgctgag aaacattttt caaacaattt tgagcaaact 2952121 tcctgtccaa tcctccaaca agcgtttttt cttatcgttt ttaggagcag tgtccagttt 2952181 ttttcggagt gaatattcgt ttaggccaaa agaaaagaga gatgaagaag tgtttagtac 2952241 cagaggtata catccataca acagactcta gatcatcata tactgaatgt atgtagaaag 2952301 gagacatcag ctttggcaaa atatcggatt atgacctttg acggcggcgg taccttaggt 2952361 gctttaagtt tacaactatt aaacagattg gctaggcaaa acccgaagtt aattagtcga 2952421 acccatgtat tttcgggaaa ttcaatcggt tcatttactg cccttgcatt agcaagcgga 2952481 agatctccga gggaaacact tcagtatttt gaggatgaaa tcctacccgc attcagcatt 2952541 tcccggccag gcggacctgt tttcaaccaa caattaccct attccggttt tattaaagcg 2952601 gtaagaaatt ttttcccagc agatcttcaa cttatagatt taagaaaacg aattgttgtc 2952661 ccatcattca aattatactc tcaaaaactg gaccgttgga ctcctgtctt atttcacaat 2952721 tttcccggct ctccctattt aaatgaaaaa gtgagtgatg tcatactgcg gagcagcggt 2952781 gctcccgcga cgcaacgcgc ctatcaaaac tatgtggacg gatatgtagt agcaacgaat 2952841 cccagtacag ccagtatcgc gtttgcagtt ggtaaagcca acgtgccatt ggatcaaatt 2952901 gcggtattgt ccatcggaac aggtgaagcc ccgactcggt taagaagaga tacgagggga 2952961 tggggaatgg taagtgcaga taacatacgt cccgaaaatc tgaagaacct tcctccaaat 2953021 tggggagtcc ttttggacag gtcgcctaat gaacctttac tgccatttct tcagatgatt 2953081 gctggcggta atgggtacta tgaatccatg gtcagtgcga atcttctggg agatcgtttt 2953141 ttccggttag atccgcggat tccgaacttc tccaaaacgg accctgccgt cgttcccgct 2953201 gtcattgaaa ttgcgaacaa aacaaactta cagcctgcga atcaatttat agagaagaac 2953261 tgggggagca aataattatt tattttaaat caattctcgc ttatacaatt ttgtccgaga 2953321 gaagattctc aaaataaata caggcaatgg gtagaaccgg atttttttaa aggtttgtta 2953381 atcacaagct aataagatga atgaaaaaat caattcatac ttcttctttt gaaagtgagg 2953441 gttcaaacta aagaatgtaa ttgaaatgtt actctaaggt atgcaattcc ctttttcaca 2953501 caaaaaaaga caagagcggc aaatcgccaa acccttgtct ttcctgttgt tctattggac 2953561 gcgctcggag ggattcgaac ccccgacaga cgtggtaccg gaaaccaccg ctctatccaa 2953621 ctgagctacg agcgcatata gactgcgtta tgagaacgtc agcacaacta attatacgat 2953681 aattcctttc aaataacaac cctctatttc gagaggccgt tttttaaata gacaaagcat 2953741 cttaattggc aatctgacat acgatggttt gaacccctgt atttttgggg aaaatgggaa 2953801 aaagagacga ctttgcatat caggccagct ttttgtttga cctttattga ccaaaaatgt 2953861 atcatgtaac tacatactta cctaaaaggt gaaggaggag cattatgaat ttaataccta 2953921 cagtcattga acaaacgaac cgcggggaaa gagcgtatga catttattct cgtctattaa 2953981 aggatcgtat catcatgctt ggatctgcga ttgatgacaa cgttgcgaac tccatcgtgt 2954041 cacagctttt attcttagca gcagaagacc ctgaaaaaga aatttctctt tacatcaaca 2954101 gcccgggcgg ctctattaca gccggtatgg cgatctatga taccatgcag tttattaagc 2954161 cgaaggtatc tacaatttgt atcggtatgg ctgcgtcaat gggcgcgttc ctgcttgcag 2954221 ccggcgaaaa aggcaaacgc tatgcgcttc caaacagtga agtcatgatt caccagcctc 2954281 ttggcggtgc gcaaggtcaa gcgacagaaa ttgaaattgc tgcgaaacgc attctcttgc 2954341 ttcgcgacaa attaaacaaa gtcctagctg aacgtactgg ccagccgctt gaagtgatcg 2954401 aacgcgacac agaccgtgat aacttcaagt ctgctgaaga agcgcttgaa tacggcctga 2954461 ttgacaaaat tttgactcac acagaagaca aaaagtaata acacaacctg caagagctgc 2954521 gtctcttgca ggtttttttc atttcaagga attgactccc ttattctata ctgctcccat 2954581 tcctcatgta acagctcaag cgtcaaatca ctcgtctgcc tcacaaccag atcagcacca 2954641 agcatcggct gtccttgacc gacaccaacc gcaaacatcc ccgcagattt gattgcagaa 2954701 atgcctgctt ctgcgtcttc tattgccgcg caatcagcag gggaaacatc gagcatcgct 2954761 gcagctgtta aaaagatgtc aggatcaggc ttccccttcg caagagtcgt cggatcaaca 2954821 atggcatgaa aatcatcgat aattgccaag cgtcttaaaa tcttaggagc attgcgactt 2954881 gaagatgcta acccgatttt tatattttcg tttttcaatt gacatagaag cctgccaatc 2954941 cccggtaaaa gatcttccgg cgtcaatttg ctgatcagca tttgataatc gcgatttttc 2955001 cgatgcataa gctcttgttt ctccgcattt gtatactttg tttccgcccc gccaaagatc 2955061 aatatgcttt caagtgactc ttctctgctg attcctttta gcctttcatt catgtctctg 2955121 tcaaaaggga tatcgatttg ttctgcgatg tgcttccaag cgagaaaatg atattcagca 2955181 gtatctgtta tcactccgtc taaatcaaaa atgaccgctt tcatatacta atgcccatca 2955241 cagcttcata aggtttgagg ctaatactct ttaagtcagc ccgctcctgc ggatagtttg 2955301 aaattagcac tttccaacgc tcatgaatca gttctggagg cgcttcgaac agagcctttt 2955361 cttccgataa attcacaacg acaagaagct tttcccctcg atattctcga aggtaagaaa 2955421 agacctgcgg atcattctcc tgcaacagct gataatcgcc atatatcata atcttatatt 2955481 gctttcgtaa ttgaatgagc ttctgatagt aaaagaaaat cgaatcttga tcttccaaag 2955541 actctttcac attgatatct tgatagcggg aatttaccgg tatccacggg tctccggctg 2955601 tgaatcccgc atgttttccg gcatcccact gcatcggtgt tctcgcatga tcccttcctt 2955661 ttatcatcac ggctttgaca aactcttttt ctgacatcgt tttgttttcg acgactagtt 2955721 cacgatatgc attctttatt tcaagatcat catacatctc cagcggcata tcgctgttga 2955781 ccatgccgat ttcttctccc tggtaaataa acggcgttcc tttcatgccg tgcagaaccg 2955841 ttgcaaatgc cttcgcacat tccttacgca gtttcctgtc attgccccag cgggaaataa 2955901 ccctcggctg gtcatggttc tcaaaataaa gggtattcca gccgacattc attaacccgg 2955961 tctgccacct tgtcatcgtc ttttttaaag caatcaaatc aaacggcttg atctgccatt 2956021 tcccatttgg cgagttttgt tctttatcaa tatccatatg ttcaaatgta aagatcatat 2956081 tcagctcttg cctgcttgca tctgtgtact ttttcgcctc ttcaatatca gagccgtttg 2956141 cctctccgac tgtcatgcag tcgtaatgag aaagcacttc cctgttcatc tcttgaataa 2956201 actcatgaag acgtgggccg ttagagtgat aacggccgac aatatagctg cggctgtgat 2956261 ccgtttcgta gtccggaaaa tcggtgtatt tagaaataga gccaatcaca tccatccgcc 2956321 agccgtcaac gcctctatcc atccagaatc tcattacatc ataaacttcc cggcgaacgg 2956381 cttcgttttc ccaatttaaa tcaggctgtt ttttcgaaaa gtagtgcaaa taatactgcc 2956441 ctgttccttc atcgtatgtc cacgctgagc ctgaaaagat cgatccccaa ttattcggct 2956501 ctgagccgtc cggtttagga tctttccaaa gataataatc ccggtaagga ttgtccttcg 2956561 acttgcggct ttcagcaaac caagcatgct catctgatgt gtggttcacg accaaatcca 2956621 tgacgatttt cattccgcgt ttatggactt catcaatcag ctgaaacata tcttcatttg 2956681 tcccaaactt ttcgtacatg tttttgtaat cgctgatatc atatccgttg tcatcctgcg 2956741 gggaatcaaa taccggggag agccagatga catccgcccc gaggtttttg atgtaatcca 2956801 gcttttgaat cacaccttgc aaatctccga atccatctcc attggcatca taaaaactgc 2956861 gcgggtaaat ttgataaacg acagcttctt tccaccattc actcattagg cgttctcctt 2956921 tcacatcgtc cctgtaggac aaccggttcc tcataaacgt tcatgtgcag cggctcgcct 2956981 tttacaagct caaaaataac gcgcttttcg tcaaccgtca cattgattaa tcgatttcga 2957041 taattgatgt tgaatgaata ttcgtcccat tctttcggca aaaacggagc aaatgacagc 2957101 gtctcattcg cggtgcgcat gcctgcaaag ccatgaacga ttgccagcca gctacccgtc 2957161 attgaagtaa tatgcaagcc ttcttccgta tcatgattgt aattatcaag atcaagcctt 2957221 gctgtgcgct tatataattc gagcgctttc ttttccagct tgagttcggc tgcgagaatc 2957281 gcatggacag agggcgatag gcttgattca tgaacagtca tcggctcata aaattcaaaa 2957341 tttcgccgtt tttcttccat tgtaaaacgg tcattaaaaa gataaatgcc ttggagaaca 2957401 tctgcctgct taataaaatt ggagcggaga atcttgtccc atgaccaatt ctggtaaaga 2957461 ggccgttccg ctggatctaa ttcgtcaact gtttgcaggt ctttgtccaa gaacgtgtca 2957521 tgctgaacga aaatttgcag ttcttcacta aatggatagt acatgtgctg gatgatttct 2957581 ctccagactt ccaattctac ttcctgcaca tccagatggc ggcgtttctc cgctgagata 2957641 ctttcgagac tttgtagagt atactccaac gtccaagccg caatgacatt cgtataccaa 2957701 ttgttgttaa cgttgttttc gtattcattc ggccctgtga cgccatggat catatactta 2957761 ttttttcgtt tcgagaagtg aacacggtcg gcccaaaatc tgctgactgc cacaagtacg 2957821 tctatcccgt attcttccat atagttacgg tcgcctgtat aattgatata attgtagatc 2957881 gcataacaga tcgcgccatt gcggtgaatt tcttcaaagg tgatttccca ttcgttgtgg 2957941 cattcatcac ctgtgaacgt caccatcgga taaagtgccc ccttcatccc caattttgca 2958001 gcgtttcgtt tggcagcctc caactgatga tagcgataca aaagcaggtt tttcgtcacc 2958061 tccggctcgg ctgtcgccaa atacatcgga acggcgtacg cctcagtatc ccaatatgcg 2958121 gcacctccat atttctcgcc agtaaatcct ttcggcccga tattcaaacg ggcatcgccc 2958181 ccgtaatatg tcgagaataa ctgaaagata ttgtagcgga ttccttgttg aagctcctca 2958241 tctcctttaa tctcaatgtc cgcttttgcc catctttcct tccatcgatc agtgtgcctc 2958301 cgttttgcat cttcatagcc gttctctacc acatccgcca aaagctcctt ggctttcgat 2958361 aaaagctctt cctcccgaaa atcacgggaa gtcgtgacaa tcacaaactt tttcaatgat 2958421 gccttcgttt gataactgta gcgattctcg acatacattt cagtcgtttt aaagctttca 2958481 tggacaaaac cctccgtctc gtttgccatt gcggctaata ccgtgaagcg cggtgttcca 2958541 aatggatttt cgatcgtttt tgccgctaaa tggccgctgt gagaatcagc acctttcgct 2958601 tcctcctgcc aaaactgttc ttggtagtta gaatcttcat ttgccacatt tccatccagg 2958661 taaggaacaa gcgtaatgac agcatctccc gtcaagcact ccgcttcata atgaatcgca 2958721 cagagttctt ttacagcaag gctaagaaac cgctctgacc tgattctgac ggttttatct 2958781 tgaatgcgga caacagcgct tcgccgcaga atcccctctt tcatattgag ttctacctca 2958841 aataattcga ttgggttttg atggagatcg attttttcac cgtcaacata taggcctatg 2958901 cccataaagt tcatcgcatt gatcactttt ccgaaatatt ctggataccc gtttttccac 2958961 cagcctactc gcgttttgtc ggggaaccac acgcctgcaa tatatgtgcc ttggtgactg 2959021 tcgcctgaat agccttcttc aaaattccct ctgaccccca tatagccatt ggcaagagac 2959081 gtcaggcttt ccagcagccg tgtatgctcc ttattaaatg tatttgtttt gattttccat 2959141 tcatcaatct caaataaccg ctgatttatc atcatttcct cccgaatgta agtttccatt 2959201 atcacggcgg gttttggtca aatatctaaa tgcaaaagag atcatcaaag taacgccaca 2959261 cgaatggatc atcaatacag taatcaaatc aaaatgaacc atgccgatag cagctgccgc 2959321 aaatgccggc agtgctgatg cgcaaatcgc tatagaggcc gcttccttga atgatgcaat 2959381 agagaccatg tttgatattt ttgtgatcca gaggccacct gcaagaacaa acgttaacaa 2959441 aagctggatc atagaaacca ccgtatatgc cagcatcatg atcatcggct tatactgtgc 2959501 caaccacaat gtatcgatca agacctctac atcatggacg tttggtttct cgagcttaac 2959561 gtccattttc gcatagccaa cagaaaaccc cgtttcgttt tgatcggtga tcaccagttg 2959621 atcaggttga aatatgatgg cgttttcaaa tccagttact ttcaatcgcc cattttcacc 2959681 gcttgtctca tattcatgct tcatatcgac tgccatcaca ttctgcccat cttcaatcct 2959741 ctcagagctc ttcccgcctg ttagttttcc gttcctgatt tgaaaaccct gcaattgatc 2959801 agcaaattga tcattaactc cttgaatcgc tgacggcatg aaagatgaaa cgctgaagcg 2959861 atccattttc acaaacgaaa ccgctaacgg cgccattaag caggccgtta aaaacagaaa 2959921 gagaaaagag agctgcagcc agctgaaggt attcccatag cggcaaacac ctgatgggga 2959981 tgcagccgcc ttcaggcagc ggatgataaa gcttttattc tccagattct tcattggcat 2960041 tacccctttg ttccgccggc tgtcaaaccg gacacaaagt tcttttggag aaaaaagaat 2960101 agaacgcata tcggcagtgc ggctagtatg gcaccggctg caaatagagc tactttttgc 2960161 tgctgcggat tagaaataaa ggattgtaat cctacagcga tggtcagcct ttccggtgag 2960221 cgaagcagaa atttcgtcag caaatagtcg ccaaacggtg ccataaacgc ccaaagcgct 2960281 tgtaccgcga gcattggctt aacaagcggt agaacaattg aagcgaaaat cctcagatgt 2960341 cccgctccgt caattcgcgc ggcttcatca atttctctcg gcacagtatc aaaataacct 2960401 ttcatcagcc acgtgttcat cggaattccg ccgccgatat agatcgctgt taaaaaccag 2960461 tattgatcga gtgcgcctat tagcatcgcc aagacataaa aagcagtcag cgccgccatt 2960521 gtcggcacca tttgaatgat taaaaagaat atcaggctct tttttctgcc tgcaaaccga 2960581 tagcggctgt acgagtaccc ggcaagtgtc acaatcgtaa cctgcaaaac catgaccgat 2960641 agcgcgatga caagtgtatt gctgtaccaa ttgagataaa gcgtttcgtc aaatagccgc 2960701 ttaaaatgat ccaatgtcca agaacccgaa aaatcgagct gaaaagccgc cgaattcccc 2960761 acacggaagg ctgatgatgc cgtaatcagc aacggatata taatgacaat acttaaaagc 2960821 gtcaaaaata aatacgtaca gattttatta agcattctgg cagtgctcgc gttcacctac 2960881 ataacctcct cattgccaaa agcattcgat tttttgaaag caatcagtga aattccaatg 2960941 acaatgaaag aaattaacag tgtcacagcc gccgcaacgg aatattgggg tgatgtgcct 2961001 gttgtcagtt tataaatcca cgaaattaag atatcggtcg atccggcccc ggctcccgca 2961061 ctgcctggcc ctccctcatt aaataaatag atgatcgaga aattattgaa attaaacgta 2961121 tactgagtaa tcatcacggg tgctgtggca aataaaatca tcgggaatgt aatatgccga 2961181 aaacgctgaa taaaagtggc cccgtcaatc tttgccgctt catacaattc acctggaatc 2961241 gcctgaagca ctcccgttac catgacatat atatatggaa agccgagcca cgtttgaatc 2961301 ataatgaggg ctgtctttgt ccagaaagga tcggtcttcc acgcgatcgc aggcagctcg 2961361 acaaacggca ggtgattgaa taatggtatc acctgtgcat tcaccgctcc tatgctgtcg 2961421 ttaaacatgt tggaaaaact catgattgta ataaacgccg gaacagccca tggaaataag 2961481 aaaatcattc gaaatatccg cttgcctttt ataaaatcct gattgacgaa aagtgccgtc 2961541 acaataccta aaatgatttg cagcgttgtt gcacagattg tccagataac cgtccagccc 2961601 agtacattca caaatgtttc acgataggag ccaaggaaaa aaatatttaa gaaattttta 2961661 aacccgaccc agtcaatcag acgattaggc ggaatatgat aaaaatcata gtttgttaat 2961721 gcaacaaaca gagtcaccaa aaccggaaaa ataatcacaa acaccatcat gatatatgcc 2961781 ggcagtgtaa atagatacgg aaaaccttta tcgcccgcat gacagatcat atccttggct 2961841 gttgtattga cttccaaacc cgccgctttc atagcggcgg tcttacgtga atcatgaata 2961901 ttaaagatat agaacatgag gaaaatcatt gtcacgatca attgcagcgt gccttcaatc 2961961 agcataaaca gcgagtgatc ttcaccggga acacttccca atgtcatcaa tccggttagc 2962021 gcctgtatac cgaaaacgca taattcaaaa gcaaacaagc ctgtgatggc aagaaataag 2962081 agcccctttg acaactgctg attcgcaatc tgcccaagtc ctggaatgat cgataaaagc 2962141 cctgcctttc gtttttgctt tgtaagtgtg tgatgtttat tcatttttcc gccctctatt 2962201 cttccggacg ctatcccgcc gttttatttc acatactttt ctttaatatt ttcctttatg 2962261 acgtttacag catcattcgc tgatgtttgt gtcgattttt ttcctgaagc tgcatcaaaa 2962321 attaaacttt ccgctcctgt ccatacttca gccatttccg gaatatttgg agtcggcgtt 2962381 gctgtttcat attgtttaat cacagctgac gtcagttcat tcttttgctc atcggctttc 2962441 ttccttgcag ccgtgttggc cggaacttcg tttgtatcct cataaaaagc gtaagcattg 2962501 gcatcatttg cagcatactc aagccatttt tcagccagct cgggctcttt tgtatatttc 2962561 gaggcaaccc agcccttccc gccagcaaaa ggggcgtatt cttctccatt tggcaatgtc 2962621 ggaatgggag ccgctccgta gttcaattta gcctctttat agttggcagc tgaccaagga 2962681 ccgccaatga tcgcagccgc tttgccttct aaaaacatct gctgaataaa gtcgtctgcg 2962741 cttgaattgt cttgcattcc tttcggccaa tatgtctcaa accatttctc cgcatatttc 2962801 accgcttcta cagccccttt attgttcagg ccgatgtccc cggaatctgt gccgtttttt 2962861 ccaaacacat atccgccgta tccagccaat aagccgtacg acatataaaa gtcagtccat 2962921 tttgctaaaa atccggttga ttttcctttt tccgaagcaa acgcgaatcg aggatcttcc 2962981 gttaactttt caaggtcttt aaatgttttt ggcgctgttt ttaaaagatc tttgttgtaa 2963041 tacaaaataa gtgtctcaat gactagcggc attccgtaca ctttgccgtc aactgtcacc 2963101 tgctgcattt ctttatcacc aaagcttttt gtgttagatg gcttaatatc aagtaaatgt 2963161 ccttgttgtc ccaaaccgcc gatccggtca tatgcagcaa gcataacatc aggcgcatta 2963221 cccgccgggc catcaagagg aagcgcttct aactgttcga acatttgctt ttcaacaatt 2963281 tttactgtga catcattttc tttttcgaac tttgttttta tgctttcaat gtattcttta 2963341 tacgtttctt cgacagacac agtcagcacc tttttgccat cagagcttgc tggatttttt 2963401 gaacttgagc aggcggcaag gccgattgcc aggaatgatg ccgccaatat ggcgaacccc 2963461 ttttttaaaa gaaccatctc ttttcctcct tctatttacg aaactataac aattgtattg 2963521 tcctatagaa agcggttaca acaactttcg atttgttacc gataacagaa tgttatacag 2963581 gggcggcagc actcaaaatc aaaaattctc ccggctgaac ggcaatgaca tcgtgatgct 2963641 gtagcggctg ctctgtccat gcatcacaga ttttcttatt cctatcaata ttcaactctc 2963701 gtaaactgac gtgttgaacc acattccctt gattaaagaa ataaatcagt attttttcat 2963761 caagagtccg cgaaaagcta atgaaatcat ttttgtcgtc cagcagattc cactcaagat 2963821 gtccttcagt caataaagtg ttttcctgct tgcgtaaagc aattaaccgt ttcataaatt 2963881 gcagcatgtc ttggttttgc ttctcttttt cccaaaccat acatttccgg cataatggat 2963941 cattttcgcc gttcagcccg atttccgttc cgtaataaat gcatggtgag cctgtctggg 2964001 caaacataaa ggccagcaac gcgcgtgctt tcttctcatc attgcggcat ctggtcaaaa 2964061 ggcgctttgt atcatggcta tccagtaaat taaacatcac ctcattggcc tgcttcattc 2964121 cattcatcaa atgtgcattg acacggtgag ccatacgtga agctgagatc gtctggtcag 2964181 caaagtattc aatcataggc tctgtaaaag ggtaattcat cgccgcatga aattcatccc 2964241 ctctaagcca gggttcggca gaatgccaga tctcacctaa aatataaaca tcaggctttt 2964301 cagtagatac agcctgccta aatgtcttcc aaaaaacgtg atccacttca tttgcgacat 2964361 ccaaacgcca gccgtcaatg tcaaattcgc gaatccagta caaagcaata tcaagcaaat 2964421 atttctgcac ctcgggatta gccgtgttta gcttcggcat atcagctgta aaagcaaatc 2964481 tgtcataatt gtcgtctgtg acgggaaaag agtgaatatg gaaccagtcc ttatagcggg 2964541 attgatctcc gtttttgacg acatcctgcc attgcggaga cgcgcttcct atatggttaa 2964601 aaaccgcatc aagcataatt ctcatccccc gctgatgcag ctggctgacc aatgtacgaa 2964661 aaagctcagg atccccgaaa tgcggatcaa tagaaaagta atccagcgtg tcgtatttat 2964721 gattagaagg cgcggaaaag atcggtgtca gataaatgcc gttcacccct aaatcctcta 2964781 aataatcaag cttgtcaaca attccttgta aatcccctcc aaaaaaatca ttgacgtccg 2964841 ggtccttgct cccccacggc aatgcattct tcggtgacaa gtcttctctt ccatttgcaa 2964901 aacgctccgg aaaaatttga taccaaaccg ttgacttgac ccattcaggc gcttgaaatg 2964961 tatcagcctc gtgaacaaac ggaaatttaa agtaataatg aatcgtttcc agtgtttttt 2965021 cgttataagg gcatacaccc gaacttccga aaaagatgtc ttcatgatcg tctgttacaa 2965081 caaacgcata ttgtaaacgc ctaaatggcg gcaccacttc agcaaaccaa tagtcatgca 2965141 tttctgtagc agcaattttc ctcatcggct gctcgtttgc cgaccatttg ccgtcgttgt 2965201 actcataggg atcaccccaa atgaatcgaa tgtgatctgc atcacctttt ttcgtccgaa 2965261 tcttgatatg cacagtccgc ccatcataag aataagcatc tgtgctgaat ggctggtgat 2965321 gaatcgctgc atattccatc atgtttcccc ctttgatttc cgttttattg aagccggctc 2965381 atagtttgaa agtatcatga tgaaattgtg ggaacaatcc ttttcaccct gttaccgata 2965441 acagaataag gcgcttacag cgttgattct cgtacaatta actctggttc aaaaaataga 2965501 cttccttgtg cagcgccgtc ttcattcatt tttttcagca acattttcgc acaggcttcc 2965561 cccatttcaa caacaggctg tctgaccgta gtcaagcgcg gcgaggagat gcgatcaaga 2965621 aacacaccgt cattcccggt aaccgcaacg tcttctggaa ttcgctttcc aagggattgc 2965681 gccgcacgaa tgacgccgag cgcgattcga tcagatgcgc agacaaatgc ggcctgattg 2965741 tccatggatt tcagcagttc tcttgcaagg cattcacttt tcttagaact gttgtcgatc 2965801 cgaaacatat tcgatttttt aaagctttta ttcatcgccc gtatataccc ctgttctctt 2965861 gcacgttcga aaggctcatc taaatcaatg ccaaaaaaga caacttcccg ctcccccagc 2965921 cccataacat ggcgggttgc cataaaagtg cctttctcgt tattcacatc gataaagtca 2965981 tagcccattt cattttgtcc aaatacgacg agcggcttct caaaagcttt tattacacct 2966041 tcaaaatcgt tctttctcaa gccggtggca ataatgccgt cacattggcc aatattaaga 2966101 gaatttcttg tcacaagctg gagagcatag tgattgcgat ccagctccct gctgattcct 2966161 gtcagcaggt tcatgtaata tggttctgtc gtatccattt cctcaagtat caatagtttc 2966221 acaacctgtg ttctgttttg cacgagcgct ctcgccgcat aattagggat gtaattcagc 2966281 tctttcatcg cagaatgaac aagctttttc aattcatccg tcaccgtctc agggtgattg 2966341 atcactcgtg ataccgtcat tttcgaaaca tttgcttttt tcgccacatc tgacaatgtt 2966401 gccattttca tcccctcctt atctgtgctt attatccaaa ctagtgataa agtcctctat 2966461 tactgctaaa tatacgatgc aggccaaaga gaaataaaaa agagatttcc cttaaggaaa 2966521 cctcactttg ttaaaaacac tcgatttttc atggattcat acgctaggtg gcagactcat 2966581 tctctccact tccatcagaa aatctctttt ttaaatttct gtccactttt tttctaaaat 2966641 cggataagaa taattttgca tttgctcaat taactcatcc ggccgtgacg agctgtgaat 2966701 cagttttagg tgcgattcgt tagaaaaccc ttcttgaatg ctgtatttca ccattttcat 2966761 cattggttca aaatatccgt ttacattgta cagtccaatt ggcttttggt ggatgccgat 2966821 ctgtgcccag cacagcactt caaataattc ttcatatgta ccgaagccgc ccggcatcga 2966881 gataaagccg tccgccagct cgctcatttt agcctttcgt tcatgcatcc cgtttacttc 2966941 aatcagctca gtcagattct gatggacaac ctccccgctg aacaaaccgc tcggcatgac 2967001 cccgattgca gttccgccgt tttccataat cgcgtcagca atcgtgccca tcaagcctac 2967061 gcgggagccc ccatagacaa ggccgattcc ctgctcagcc atatacacgc caagctctgc 2967121 cgcttttctt ttatacgctt catttccccc agggtttgat cccgcaaata cacaaatggt 2967181 tttcatcttg tcatctccgc atctatatat cgtgttaaac attcaaaaac acactatata 2967241 ttgtcccatc ttcatgtgat aatatcaata tgaaatacat aaagaatgca ggagtgatga 2967301 ggttgcagct ggctgatgca gaaaaatgga tgaaagagtt ttacgaaaaa agaggctgga 2967361 cagaatacgg accttttatt cgcgtcggct ttttaatgga ggaagccgga gaactggccc 2967421 gggctgtcag ggcgtatgaa atcggcagag accggccgga tgagaaagaa tcgtcacgcg 2967481 ctgagcaaaa acaagaattg attgaagaaa tgggagatgt catcggaaat atcgccattc 2967541 ttgctgatat gtatggtgtc tctttagaag acgtcatgaa ggcccaccaa gaaaaactga 2967601 caaaacgatt tgagcatgca taaaaaagcg gccgcgatgg ccgctttttt taacctgtga 2967661 tttcatcatg gtgatcaaag aaatgctgct ttcctatttt gtgaaaaagg cctgttttat 2967721 gcagtagctc cttcggctgc gattgcaatc ctacaatcat cagctttcca ttgtggcgtt 2967781 taattcgatt cataatgttc ccaagcaccg cttcagctga cgtatccata tagtgcacct 2967841 tattcatgag cagaataagg gttttcggtt ttttctgtac atgctccagc aatgacgatt 2967901 caagggaatc aattgatccg aaaaacagcg gcccttctat ggcatacatg ctgacagatg 2967961 gatcttctct cttcgccaga acaggatgcg tttcctgatt gtggatgcgg gtcgcttcgc 2968021 tcattcttct gataaagaac acgaatgcaa gcagcaatcc ggttgccaca ccgatgatta 2968081 agtcaaacag aaccgtaagg gcgaaggtcg ccgccaaaat aaaggaatca gcatttttca 2968141 gtctcagcat gtttgcgact tccttgcgct cactcatatt ccatgcgacc accatgagaa 2968201 tcggtgccat actggcgagc ggcacatggg acgcataagg cgcaaataca agcaggacaa 2968261 ggagaacgac tacgccgtga acgacgccgg aaactgggga aaccgctccg ttttttatat 2968321 tggtcgccgt tctcgcaatc gctcctgtag ccgggattcc gccaaacagg ggcgctgcca 2968381 tattcgcaat cccctggccg acaagctcct tgttgctgtc atgctttgag cccttcatgt 2968441 tatcagcgac cattgcggac aaaatcgact caagtcctcc aagaagcgcg atgacaagcg 2968501 cagccggaaa cagcataacc attttatcca aagtaagctc aggaaactga aattccggca 2968561 aatggcgggg gatttctcca taagttgacc cgatcgttgc catgcggtca gggaaaaaga 2968621 caaccgcgac cactgtggaa ataagaagcg ccaacaaagc gcccggcact ttaggcatca 2968681 ccttggcgga tacaagcaaa atgacgagcc cgatcacagc tgtcaaaatg gcatacacgt 2968741 taaaggtgcc gagctgctgc acaatttcaa acatgttgtg atgaaagttc tcatgttttt 2968801 caacatttct caatccgaga aaattagcga tttgttccgt aaagatcagc acggcaattc 2968861 cggctgtaaa accgacgata acgggtttgg gcacgaattt cattattttt ccgagcttaa 2968921 acagcccaaa cagtaccagc atcactcctg ccataaaccc cgcaatcagc agattttcca 2968981 agccgtactg catgataatg ccgaataaaa tcgggacaaa ggcgcccgtc ggaccgccaa 2969041 tctgatattt tgatcctcca aacaaagaaa tacaaatccc tgctataaca acagtgtata 2969101 gcccatattc aggctcgact cccgaggcaa tggcaaacgc cattcctaaa ggaattgcca 2969161 cgacacctac tacgatacct gcaatcaagt ctttctgaaa tttctgcaaa ttgtatccct 2969221 tgaatctccc tgagaatcgc atattttgtt ataacctccc ttatgagtga ttgtttataa 2969281 gctcagtttc ataaccgtta atgaccacat caagttttcc tgtttcaggg tgaatgacaa 2969341 gcccgtgaac cggcactttt ttcggaagca gcggatggtt cttaatcatg ttcacactgt 2969401 gggaaacgct ttcttccacg ctgtgaaaac cagtcagcca cgttttcaaa tcgagtccgg 2969461 cactcgtcag caaattcagg cagctatcct ccaccccgcg ttcctttgct ttctcaagaa 2969521 tcgaggacgc attcagccct gacattccgc attcatgatg gccgacaatg catacctctt 2969581 cagcctgcaa ttcataaatc gcgaccagta tgcttcgcat cacgcttcca aatgggtgag 2969641 aaacgatggc tcccgcgttt tttacaattt tagcatcacc gtttttaagc cccattgctt 2969701 gcggaagaag ttctgtaagc cttgtatcca tacaggtgac aatgacgagc tttttcgaag 2969761 gaaactttgt cgttttgtac ggttcatact tcttctcact gacaaaccgc tgattgtgtt 2969821 ccaaaattga tgttaaagaa accatttgat tcatctccca tccatatgat tttgcaagcc 2969881 ttcttaccca gcttacagta aggaattata gcataggaat aagccaagaa aaggttttca 2969941 aaaaaagaca ctataattgg actgtagaat caaaacataa acatttatat ctttcaaaga 2970001 taataaaatt tatatttaat gcatcctata atccggctgc agttcgtata tcgatgattt 2970061 gtctgacaaa aaatatgggt gaattctgat aattaaaaaa cttttttaag cagatttagc 2970121 tgttcgatct tcattttaag ttcaaaagaa ccagaaatta aaaaaacgca gctatatttt 2970181 taacatctat ttattttcga tataatgaat tagacaacag ccataaaggg ggagccttgt 2970241 tgaaaccatt tgtatttatc acaaaaccga ttcctgaaga gattgaagca ttcatcggtg 2970301 aacattgccg ttatgaagta tggcaggagg atacgcttcc gagtgacgtg ctatttgaaa 2970361 aattaaaaga agcggagggg cttttaacat cagggacgtc cggaccgtca atcaatcgtg 2970421 agttgctgga acacgcgcct aagctcaaag tggtcagcaa ccaatcagta ggctacgata 2970481 acttcgatat agaagcaatg aaagaaagag gagtcgtcgg gactcataca ccttatacac 2970541 tggatgacac agttgcagat ctggcttttt cactgattct gtcttccgcc agacgtgttg 2970601 ccgaactgga ccgttttgtc agagcaggaa aatggggaac cgtggaagag gaagcgcttt 2970661 tcggaattga tgttcatcat caaacgttag gcattatcgg catgggcaga attggagaac 2970721 aagcagcgag acgcgccaaa tttggttttg atatggaagt gctttatcat aaccgacatc 2970781 gcaaacaaga aacagaagac agcatcggcg ttaagtatgc agagcttgat acattgctgg 2970841 agcaatctga ttttattctt ctcattacgc cgctgactga tgaaacctat cacatgatag 2970901 gagaacgcga atttaagttg atgaagaatt cagcaatttt cgtcaatatt tcccggggaa 2970961 agacagttga tgaaaaagca ctgattcgcg ctcttcagga aggctggatc aggggagccg 2971021 gcttagatgt atacgaaaaa gagcctgtca cccaagataa tccgctcctg cagctggata 2971081 atgtcacgct gcttcctcat atcggttcag caacagctaa agtgcgcttc aacatgtgca 2971141 aacaggccgc cgaaaatatg ctcgcagcga tccaagggca aacaccgaaa aatcttacaa 2971201 gagaatttca ataaatcaaa aatccggtct gataacagac cggatttcat attacatacg 2971261 ctgaagaaca gcacgcttat aaatatgacg ggtgacgata taataaagag cctggaatac 2971321 aaaataaatg aagatgacaa ttacggcctc aagaaataaa ttggaattca gcatattact 2971381 taacgctgca tacgcaaagc ccgcgtgaat cgtacctgcg ataaatggga tgaagaataa 2971441 aaatcctatt tgctttccaa ggatcgagtg aatctctttg tccgtaaccc ctatcctctt 2971501 taacgctaac acctgcactc ccgtatcttc tatttccgta aacatccgca aatacagcat 2971561 gcttccttgc acgataaaaa acagcacgct gacaaacaga ccaataaaca gcattaatgc 2971621 aactccctgc ttcacaattt gataactagg agcacgtgtt tgaaaatcag atgtatgttc 2971681 tttcggcacc atgttttcaa gcttttcaga gacatccacc gtctcctgcc aatgctcaag 2971741 ctcataacct accattctca tctgttcctt cagcggcaca tcctgtgaca gactgtcaaa 2971801 gctcttttcg ctgacaacca ataaacggct gactccatcg acagacatca atatcccttt 2971861 gttttgctgc tttttcatga cataggaaag ggtttttcct gacttcatat gaaatgctgc 2971921 tgtttcccct tctccaaatg tgtctttcac catcatttga aaagaaacat taataaatgc 2971981 ttcattttct tgtaaatgaa taactgggaa ccctttttcc tttgcgactt gattatagac 2972041 tttttctgaa atcagcaaag cttcagcttc catcttctta tttccatacg gcaagtctga 2972101 ctgaaaagtg acaggaatcc ctgtggcatc caccttatac gtgataacag catgagcttt 2972161 tttcaatgta ttctcagccg tctcaggctt catgacctga aagcgggaag catccttttc 2972221 cacccaggaa acagactgag gaatgctttg ctcctcctgc ctttgtaaat cggaataaaa 2972281 catatagatg acacctgtag ctgttagtat gaccgctgta atgacagagg ttaaaaacag 2972341 catgcgtgca tgatccttca gcctgaatat catgttggaa cgcacaatga tatttgtgcc 2972401 tttgtagaag ctgtgtttct ttcggtacag catgcggaaa aatgccacac tgctttgggt 2972461 aaaaaagaaa tacgtgccaa ttaacactaa aatcaaaatt ggaaaaaccc gaaacatcat 2972521 gtcaattgca ttggctgttg cagatagata ataaccgctg ccaagacata gcaaagacaa 2972581 tacagtgagc catttcgaat aaactggcaa acttttcggc tttttggctg atttaatcag 2972641 ttcaatgatt tccagcttcc gaatccgtcc cagtgataaa atgagcagcg tctgaaacag 2972701 gatgagaaag ccggcaattg tcatcacaaa cgctttcggc acaatggcaa acgaaatcgg 2972761 caccttcacg ctgagcatcc atgtcatgat cataaaaaac agttttgaaa ataacaggcc 2972821 tgctccaatg ccggccgcaa tcgccgcaag agaaataagt gactgctcat aataaatcat 2972881 cttgcgaagc tgctgctttg atgtgccaaa cagtgtcagc agcccaaact ctttctttct 2972941 tgcctgcaaa aacgctgaat tggaatatgt gatgaaaaat atacaaaaca caatgatgac 2973001 gacaagagct gcgctcaagc atgttttgac aaggcttcct ccatatatat tgtcttcatt 2973061 gacatcagga tgaaaaataa atgatgtgaa gacaaaaaac accgaaacgg caaacacaca 2973121 gcttaaaaag taggccacat accgttgcag attcccaaga atgtttttac gggcgatagt 2973181 tctcaaattc atgaaaatcg cctcccaaca cactcaaggt atccaatata ctttgataaa 2973241 acacctgcct gtttgttcct ctgtgaatct ctgaaaagaa acgtccgtct ttaataaaaa 2973301 caatccgttt acagaaactt gctgctgtgg catcatgcgt aaccaacaaa atcgtcgctt 2973361 ccttttcctc attcagctga gccagtgtgt tcatcacttg ctttgccgat tttgagtcga 2973421 ggtttcctgt cggttcatcg gcaagaatga gcgccggatt gtgaataatc gctctggcac 2973481 aagctgcccg ctgctgctgt ccgcccgaca cctcatatgt gcggtgatcg agaatatgct 2973541 ttatttgcag cgtatccgcc agttcatcca atcgagcttc catttctctc agctttacct 2973601 tatccaatgc gagcggcaag agaatatttt cacgaatcgt cagcgtatca agcagattaa 2973661 aatcctgaaa gacgaagccg agttctcttc tgcgaaacaa agccagctct tggtccttta 2973721 acgttttcgg ctgaatgccg ttgatcatca tctcgccctg ggtcggctta tcaatggtag 2973781 ccagcaaatt caaaagcgtg gtttttccgc ttcccgacgg ccccataatc ccgacaaatt 2973841 ctccttttga cacactgaga tcaaaggcgc tgagcgcttg gtatgatatt gttcctttat 2973901 ttgaatagta tgttttcgat aggttcgttg tttgcaacac gttcatgttc tgctcctcct 2973961 ttttctttat tataaaaagg aagtcagcat cctcccatcg aactttcttg caattccgct 2974021 ccccaatctt acaatgctgt cacattcacg agggtgtcac ttgaaaacac gatggtcatc 2974081 acagtgccag ccccttcttt tgattccgca tacagcttat ggccgagacg gctgcacacc 2974141 tgttttgcta aataaaggcc cattccagtt gcctctttca tggttcgtcc gttttctccg 2974201 gtaaaaaacg cgtcaaaaat ccgcggcaga tcctgcggcg gtatgccgat tccttcgtcg 2974261 gcaaccgaca agcgcgtctc atgtccctgt gtttcaatcc ggattgtaat agggtctccc 2974321 acaccttgct ttgaatattt taaggcgttg aaaaggattt gctcaacaac aaaggaaagc 2974381 cacttttgat cactggaaat ctgaacggca tttggcggca catgtaatgt tggaaaaagg 2974441 cgccgcttga taaactgacg tttttcctga ttgatcagtg aacgaaccat ttctgccaaa 2974501 tcaaaggttt gcggctttac atcaaatgca aattcctcca gccgggccgt ttgcagcatc 2974561 atatcaagac cgtggcgaaa tctctcattc tcatcctcca gctcctctaa aaacgtcgga 2974621 aaagaggatg aggttccgtt ttttccttcc tgaatcatta aggatatgac agataccggt 2974681 gttttcatat ggtggaccca ttggttggtg aaggtgtaat gctgtttttg ctgattgata 2974741 tattgtgaga gcctgctttc gtattgctgc ccgagtgcgt tgatcatctt cgtccaaagc 2974801 gcttgctctc ctgttcttgg ctttctggct ttcaaagact gtccgatgtc attcgaagaa 2974861 gaggcttgtt ctgcaagctt tttaacatat gtgagaaagg aaaattgccg aacataatca 2974921 gcagcaaaac ctgcggctaa aagagtaccg ggcaaaatcc atatgtacat catattttct 2974981 ttggaaggtt ctgcgccgct ctctacaatg cttaaatacg caatcagcat ggcggaccct 2975041 atccctaata atgaaaatag aataatggct aagcggtcga tgagataagt ctttaacatt 2975101 ccgcttcatc cttccgattg acttgaaatt gataaccttg tcctctgatt gtggaaatgc 2975161 aatctgtcag tcctgcattc tccagttttc tccgcagccg attgacattg accgttaacg 2975221 tattgtcatc gacaaaatca acgtcatccc ataacgcctc caatagttca tcacgagaga 2975281 caattttttt atgctccctc acaaaaatcg agagaagctg gaattctttt tgggaaaaca 2975341 aaatccggac gctgttccat tcggcctcat tctgatcagg ataaatcgtc agcccgccaa 2975401 gctccactat tctagattcc tgcggcaaag agggcgaata ttcaccatat gtgcggcgca 2975461 ggacgctttt gattttggcc atcactacct ctagatggaa cggctttgtg atataatcat 2975521 cgccgccatt ttcaatcgcc attacctgat tcagctcatc ggtccgtgcc gatataaaga 2975581 taatcggcgc attggaaatg gtacggattt gcctgcacca ataaaacccg tcaaaaaaag 2975641 gcaggttgat atcaagcagc acaagatcag gcttcatttc tgcaaattcc aattttatat 2975701 cattcagctg ttcagcaatt ttcacttcat atccgtattt ttgaagatga ccgcccagca 2975761 aagaagcaat ccgctcatca tcttccacaa gcaaaatccg atacacgttg atccccctta 2975821 tatgtacatc acgatgattt ttctagaaga ttccaaaatt attatagcat gtgcggaata 2975881 gtaaatcggt ctttttcttt ttgttatgat agaatgataa aggtaaaatt ttcataatag 2975941 gcaggtgtcg tgatgaagaa aatcatgctg tttctggcaa tgacgtcaat tctttcagca 2976001 tgtcagccca actataccgg gaaatacata gaaattgggg atacactaac tgactatacc 2976061 aaagagtgct ttaaagagaa tgaaattcct tataaatacg aaaagggaaa actgtatatc 2976121 ccagaagacg catttgatac agcaatctac acttgttcat aagaaaaagc ttgcagataa 2976181 cctgcaagct tttcacgtta caaaaaatga gtatttaatt tctcttcaaa tcctgaaggg 2976241 ccgatgtcgc ttttttgaat gttaccgccg ttttcataaa tcgtaaaatg gcgctctgac 2976301 atgaccatcc ttccgctcgg cgtcagcttt gaggcaagca gggatttgtt aaaaggagat 2976361 ttttcatgag agtgaatgat gtccttcatg ttatctaaat caccgagatc actctcttca 2976421 agggtaaagg cgtacccaat ttgccagcct tctcctttgt ccatcagcag aacatagctg 2976481 cccttttctg tctcttcctt tttgattcgg aatgacccga ctggtgactg taccgtttct 2976541 ccggaaagcg gtatcggctg gagcgccagg ttgatgccga agccgatatc aacgaggtaa 2976601 tcgccgtttt ccgcagacag ccatacagca gcatgcgtcc cttctagtgc ccatccctct 2976661 tgatcgcctg cataaaccgt tcctcgaatg agcttcacat gaaacccggc ctcacgcaag 2976721 acaaaataaa ggaaaccatt tagatcgtag cataggccgc cgtgctgatc tttgagcaga 2976781 cgtcgccata gctcttcttt tgtgatctta taattctctt ttgcaagtac ggcacggttt 2976841 tcgaatggaa aacggtatgc cattgcttta agaaaaaggg gaagatcgcc gaagctgaca 2976901 tggtctttct cccagccgat tttctgaaag cagtctttta gaaagtcact catttttatc 2976961 acctaaactt cttcttgaac gtaagcagcc agcttctcca gcgcctcttg ttcatcttct 2977021 ccctgggcaa tcaaggtaac ctcagtgcct gtgcttaccg caaggctcat cagccccatg 2977081 atgcttttgg cgtttacttt tttcccatcc ttctcaagaa acacatctga cgtaaaccgg 2977141 tttgcttctt gtacaaacaa agcagcagga cgtgcttgca gtcctgtctt taatcgaact 2977201 tccactttct gttgaaccat aagatctccc cttttcttta cggttatttt aaagtgacgg 2977261 tttgccctgt ccgcagctgt tctgcgattt cgtcaagttt tctcagcctg tgattgatcc 2977321 ctgatttgct gattttcccg cttgctacca tttcccctag ctctttcagc gtcacttcct 2977381 gataatcaat ccgcagctgc gcaatttccc gaagtttttc aggcagcgcc tccaggccga 2977441 ttctttcatc gatgtattta atattttcca cctgtctcag cgatgcgccg atcgttttgt 2977501 ttaagttggc tgtttcacaa ttgacgaggc ggttgaccga atttctcatg tcccgaacga 2977561 ttctgacatc ctcaaatcgc agaagcgaat tgtgagcgcc aattacgttc agaaactctg 2977621 taatcttttc agcctctttt aaataggtaa tatagccttt tttccgttca agcgttttgc 2977681 tgtttaactg aaactcattt aacaggtcac ataatgaatc gttatgctcc ttataaagag 2977741 agaagatttc taaatgatac gaggaggttt ccgggttatt gaccgaacct cctgccaaaa 2977801 atgctcctct catataagaa cgcttgcagc atctcttttt gaccagctct ttcgaaatac 2977861 ttcgttcaaa cacaaaattc tccccgagta tttttaaatc ctctaagatc gcttttgcat 2977921 tttctgaaaa acgcacaata tagacgttat tctttttcag ccgcattttc tttctgacca 2977981 gcagctcgac cgacacatca tattgttttt tcagcaatgt atagatgcgg cgggcaatcg 2978041 ccgcgttttc ggtttgaaca tcgagtacga gatggcggtt tgtaaatgat aaagctccat 2978101 tcatccgaat gagtgcagac agctcggcat taatgcagca gtccttcact tccagattcg 2978161 ttaattcttt ttttgtttct gatgcaaatg acatatagcc acctcatttc aaggcttcat 2978221 tctttcagta aatcaacaag aagagaggcc actttatgtg tatcgtgacg tattacgtca 2978281 tttttatacg ttacaatttg atctctgatg acttcaagcc ccatcgcttt cagctcttcg 2978341 atatcaaaat caacaggacg cgccgattcc atttcgtact tacgttttat ttcgtcggga 2978401 atgtcttcac tgttcactaa tatcgtatca ataaaaccac agcccatatg ctgattgagc 2978461 gctttcacat gatcagcagc ggtgtaatgg agcgtttcgc cgggctgagt catcacgttg 2978521 caaatgtata cttttttcgc cggcgccttt atcacttctt ccccgatttt tgggacgagc 2978581 aaattgggaa gaatgctggt atagaggctt cccgggccga taataatcaa atccgcttcc 2978641 ctgattacgt ctattgtttc cggcagcgga tcaatctgtt caggcgtgag aaaaacacgc 2978701 ttaatgcgct gtccgtattc tgggatcgtt gactcgcctg agaccacgcg gccatcttcc 2978761 atctcagcat gcaaaacgac actggcattg gcagccggca aaacctttcc tcttacattc 2978821 agcaccttgc tcatttctgt gacagcgtga aaaaaatcac cggttatatt tgtcatcgct 2978881 gccaaaatca aattcccgag agaatggcct gttaagtcat tccctttatt gaagcggtgc 2978941 tgaaaaagat cttcaacaag cggctccaca tcggataaag cggcaagcac atttctgatg 2979001 tctccgggag gcggaatttt cagttcattc cgcagacggc cagagctccc cccatcatcg 2979061 gcaactgtta caatggccgt gatgtcaacg ggtttatgct ttaggccccg aagcaataca 2979121 gaaagacctg taccgccgcc aaagattgcg attttcggct tttgtcccat cttatttccg 2979181 gcttctcttt tcaatgtccc ggtgagtaac atgagtatag taatcctttt tgaaataatc 2979241 agctaaattc tcggctaatg tcacagagcg gtgctggccc cctgtgcagc cgatcgcaat 2979301 gacaacctgg ctttttcctt ctcttttgta agatggaagc ataaagctca gcagatcaat 2979361 taatttctca ttgaactttt gcgtttcatt ccacttcatg acgtaagagg aaacctcttt 2979421 atccttgcca gtcagcggcc gcatgctttc gatatagtac ggattcggca aaaatctgac 2979481 atcaaagacg agatctgcat caattggaat accgtattta aaaccaaatg acatcacatt 2979541 tacggtaaat gtctctcctt ggtttgtcgc aaagtgcttc acgatttttt cacgcaaatc 2979601 acgcggcttc atgtcagacg tatcgtaaat gatttgagag cggcctttta attcctcaag 2979661 cagctctcgt tctagcgcga tgccttcaag cggcaggcca gtcgctgcca gcggatgcga 2979721 gcgtctcgtt tctttatatc ttgtgacgag aatggaatcc ttcgcgtcca ggaataaaat 2979781 tcgcggtgtg atccacggat tttcggccat ttcatccagc gcttcaatca gccggtcaaa 2979841 aaattcgcgg ccgcgcaaat ccatcacgag cgcaactttg ctcattttcg aatttgattc 2979901 cttcatcagc tctaaaaact tcggaagcaa tgaaggcgga agattatcga cgcagaaata 2979961 gccgagatct tcaaagcttt ggatcgcgac agttttcccc gctcccgaca ttccagttat 2980021 aatgacaagc tgaatatcat gtgattcact aacactcatc tttctccccc ctgacttgtc 2980081 tttctatttg atgtgctgcg ggtctaaacg ataactgagc agctcaaatt ccggtgtata 2980141 cgtaaatgtg ccgtgcagca gcccttgtcc cttcatcata aaatcaagga tatggccgtc 2980201 tccaggggcc ataggcaggt tctgaatgtc attgacatcg tgccactgca gtttgccttc 2980261 ctctgattct gatacatttt gtcctgtata tgaatcagcg acaaacgtaa acatcatcca 2980321 ctcggagaca atgtggtcac cgtctttaat aataaaggta aaaacgcctt ttaattgagg 2980381 atttatgata tagataccag tctcttctct gtactctctg atgacggagt ctctgactga 2980441 ttctccgctc tccatcttgc ctcccggcgc gacccaccat ccgcgtctcg gcttttgaag 2980501 cagaagaact ttgtcatccg tctgaagcac acaatttgtc actctttgca agtacgtcac 2980561 ctaaccttcg tcctgtcatc gtctctttat tataccgctt caagatgcct cccacaatga 2980621 agagacattg acaatctttt cttctatttt acagcatatt cattccttaa ttcagatgat 2980681 tttgctgtaa ctggaattct cttttattta tggacaaaaa aaggacacgg ataactggag 2980741 aatccgtgcc aaaaaagtgt attcattata aaaagggggt caattacttt attaatcata 2980801 accgaaaagc attacacatg tgttacagcg gaattaaaac ccagtaacgt aatgtgaaac 2980861 tcgtatgaca gcccttttta ttttaaggtt ttcagcgttt cttggagctc ttcgacataa 2980921 tgttgtacgc tttgtgccgc aatgcttccg tctcctgtag ccgttacgat ttggcgcagt 2980981 gatttttcgc ggatgtctcc ggcagcgaaa atcccttcaa ccttagtttc catgcggtcg 2981041 tttgtttcga tatagccttc ttcattcgta atgcccaggt tttcaaacgg tttagacaga 2981101 ggaagcatgc cgatgtaaat gaatacgccg tctgttttga attcactttc ttcaccggtt 2981161 accgtatcga caagcgttac gttaccgact ttgccgtttt cctcatgaat ttccttcaca 2981221 gttttgttcc ataggaagtc aactttttca ttatcaaatg ctctcgcttg aagaatactt 2981281 tgagcacgga gtttatcacg tctgtgaaca atcgttactt ttgaagcgaa acgagtcaga 2981341 tatacgcctt cttcaaccgc ggaatctccg ccgccaacaa cgacaagttc tttgccttta 2981401 aagaaagcgc cgtcacatac tgcacaataa gatacaccgc gtccgcccaa ttctttttcg 2981461 ccaggcacgc cgattttttt atattccgca cctgcagcaa tgatgacagc acgggcttta 2981521 tattcctttg aaccagcttt gactactttg tactctttgc cgtcaatgac ctctttaata 2981581 tcgccataag cgtattcagc gccgaatttt ttcgcgtgtt caaacatttt gttagaaagc 2981641 tcaggcccaa ggatactttc gaatccagga tagttttcta catcttccgt attggccatt 2981701 tgtccgccag gaattcctct ttcaatcatt aatgtcgata aattcgctct tgatgtgtat 2981761 acagcggccg tcatcccagc agggcccgcg ccgattataa tcacgtcata aattttttct 2981821 tctgacacac tattcactcc ttaaaccatc ttttcaagtt tgggctcttt cttataagat 2981881 aagaatcccc atcaaacgta ttccttaccc atatcctata aaatctcatg gtgatacgct 2981941 atttttttgc tcaacacgat taaatgtatt cgaaaagggt atatgttaat aaagaaagag 2982001 ccttctgttt atagaaggcc cttgtcatat ttattattga acaacacgtc ttacaacacc 2982061 tttaaatgct gctttccagt aaggattgct catagagtca acagatacgc catgagatgt 2982121 attgtcgttt aggaaagtac cgtttcctaa gtagattcct acgtgtccat ttgttttgta 2982181 agtgtcaaag aacacaaggt ctccgcgttt catttcagac gcgctgacag cttgtcctct 2982241 gccaactaac gtatcagttg ttgttccgcc tacaggtcca aggttaacac ctgcagaagc 2982301 gtatgcccag cgtacgaatg atgagcagtc aaaaatacgg ttgttgatat cagactgagt 2982361 gcgtccgccg ccaaacttgt acggagattg tcctacaatg cttgaaccaa cgctgatcgc 2982421 gccttcaatt ccgccagagt tgctgataac agtgccgcct gaattgctgt ttgagccgct 2982481 gctcttctta gaagatgagc cgtttgacga actgtttgat gaaccgttag aagaattgtc 2982541 tgaagaattg tctgaagaat catcagatga gcttgctttt gatgattcag ttgtcgccgt 2982601 ttgactgtca tctgtttgtg tttcatcaga tgctttttgt gcttcttcct gctttttgat 2982661 caaagcagcc gctgcttctt gttctttttt gatgcgtgct tgttcagctt cagtatttgc 2982721 tttttgattt gcaagttcag acgcctctga ttttaattca gaaatcgctt tagccgtttt 2982781 cttttggctt gcttttgctt cgtcgaaaag cttgtctttt tcattaagct gtttatcaag 2982841 gtctttttgc attgtttcta atttagccaa ggcagcttga acttctttca gcttgtcatt 2982901 caaatccgct tcagaatctt cgagcttcgc tttatcctgc tcttgctgtt tgattaaatc 2982961 tttgtctgcg tccacaatag atgaaaccgc agtcgcacga gagataaagt caccaaagct 2983021 tgttgatcct aaaagaacat ctatgtatcc ttgagatccg ccgctttcct gtaaagaacg 2983081 aacgcgtttt ttcaggattt cattgcgttt ttcgatgcgt gcttcagttt ctttaatctc 2983141 ttttttcagt tttttgattt cttcttttgt tttatcgttt tcttcttttt tatcttcaat 2983201 cttgttgctt gtatcaagcg ccttatcgtt aatgtctttc agttcttttt caatctttga 2983261 ttgattttcc tgaagctcgg ttaattcttt ttccttcgct tcaatgctgg aagcaacctc 2983321 agattgcttg ctttcgattt tttgtttctt ttcatctaat gtttccgccg atgcagtttt 2983381 acttgtaaat gggatcaaaa aactgcttgt cccgatgacg gaagccaaac caagtgtaat 2983441 taaactcttt ctcacttttt atatcctccc ttttactgtg aacctgtcct catttggaat 2983501 cgtattttga acatcaagtt tcgttcctca tactctacga ggaatgatgg ttgtttatgg 2983561 ttaattattc tgtgcatctc ttattctggt tgtatagcgt ttatttcaca tcatatgtaa 2983621 aaaacactaa ttccttatgt acgagaatca ttataccatc aagtttcgac aaattagcga 2983681 taaattttat tacatttatg tttcaaacag atgtcaagtc acacatcatt tgtcattttt 2983741 cttaagcgtg taaaaaaact gtcgatatta ttttcttaat ataatctatc taacaaaaaa 2983801 agagtcgatt aaataaatca actctttaaa atttactatt ctagaatatc atcaatatat 2983861 ttcatatatt tcgtcaaagt tgccggagag atgccgaatc gggccgctgt gtcttttttc 2983921 gtgtcttgct tgccatgggc ttctttccaa atataacaga tggctgctgc ccagcctttc 2983981 tcattcttca acggagcagc tgcacgaatt tgctggatga catgaaaaac ccagcagctc 2984041 atgacttctg ttttcatctc ttctttttca gcttgctcta atagtttgac cgtttgataa 2984101 gcgaaaagtg catcctctga aacgtcagca gccgcagaat ctccattcag aagcagcttt 2984161 acaaaatgag tttcaaaagg agcggtaatt ctctttgagc gtatcaccgc ttcaagatgc 2984221 tctgtttctc cctttgtgct gctgatataa taggctgcga gtcgctgctc cacagatgaa 2984281 ggaagagctt ccctccgctc aatccaaggc gccgggcggt cttcgccggg atattgcgac 2984341 tcgacttttc tccagatcgt ctcggcaaag tcggtatgtc ccgtaaaata agcagagcag 2984401 gaaagccagt aaaagaaggt gtcgtcaccc tcaaagccgg ttttatataa tgatttgagc 2984461 catttatatc cgatctcgta gcggccgaca agcgccaaag tagcacccaa tttataacgc 2984521 tgctccaata gcatcggata gacattggag agctgatcac tcaattccgc cactttttcg 2984581 tcttctcttt cataatagta gaaaacgaga agattgcata aggcgtgaag atttccttca 2984641 ttatgagaaa gcacttcata agcggtttgc ttcgctttta caacgtttcc tgaatagaaa 2984701 taggcaagcg cgagattgtt gtatgctgac caaagctccg gatattcagt tgtgatttcc 2984761 tcaagcgccg caaccgcttc agcaagctgg ccgctttcca gcaatgactt tgcccgatcc 2984821 tgtttcacca gcagttcatc ctgatcatac aacgaatcct caatgccgtc gtctcctaaa 2984881 tcgagcaaat caagcagact atcgttttct tcggcgaatt caccatccgg gtccgcatca 2984941 gaataagcgg ccgcttcttt ataagcttcc tggaagagcc ccagatgggc aaagttattc 2985001 gctttaaagt aatggcactc cggcatttcg gcctccagat ttgccatgat atagtcaaga 2985061 agatcgttcg actcttgata ctggcccatt tccgaataaa tgaccgcaag ctgtgaaagc 2985121 atctctgaat cctccggctc caaatgaacc gcgcgctgaa tcagtttgct tgcccgtttt 2985181 agattgcgct ctttatacgc tttcaagcct ttatgaaaaa aatattgtcc atcttgaagc 2985241 agctggacaa tttgtgcgtg atttttatgt tcagaagtgt gttttcccac aactaccctc 2985301 cgttttatac aatattaccg tcagtagtat accataaatc gtaagcccct caatagttca 2985361 aaaggaagga ttgggaaaat ccctcctctt ttttattggc tgattcgacc aaaatttacc 2985421 cggctttgtt ttctaagtcc gcattcattt tcagctgctg ttcagcaaaa tcccggtaaa 2985481 ggccatggga agccattaac tcatggtgtg ttccacgacc ggtaatttcc cctttttcaa 2985541 caaacaaaag ctggtccgca tctacaacgg tagataggcg gtgagcgata acaatcgttg 2985601 tgcggccctc catcagcacc tccagcgcct gctgaactga tttttcagat tggctgtcga 2985661 gacttgaggt agcttcatcg agcataagaa tgcttgggtt acggagaagc gctctcgcaa 2985721 tcgcgattct ttgcctttgt ccgcctgaca gcataatgcc gcgttcgccc acttctgtat 2985781 caaactgatt cggcagctcc tttataaaat tgagcgcata tgccatctcc gcggcttttt 2985841 cgatctcagc atccgtcaca tctcgttcta acccgtagca aatattttct ctgattgtcc 2985901 cggacattaa cgggctttcc tgtgatacat acccgatatg ctccctccac gattcaagcg 2985961 agtaagtatc gaccggctcg tcccccagcc gaatggtccc tgcagtcgga gaataaaagc 2986021 gttcaagcag cttaaacagc gtcgtttttc ccccgccgct cggaccgacg atcgctgtca 2986081 ctttccctgc ttcaatgacg gcgctgacct cttttaagat cagctgatca ggcttatatc 2986141 caaaagacac gcgatcaagc tggataggca gatgtgcatt ttcaatttgt tttcctgtca 2986201 ctgtatcttc ctcttcctct gccaaaatct caatcattcg ttctgttgca ccgattgatt 2986261 tttgcagctg tgtgaaaaac gttgtaatct ggcccatcgg cataataatt tgaaacaaat 2986321 ataaaataaa agccacgagc gctccggctg tgagctcgcc tgatgagacc tgcatgccgc 2986381 catatccgat cactgcgaca agcgctgcca ttaacacgag tgaaataagc gggccgacaa 2986441 gcgattgaac cttggcttca cgaacgccaa gcttaaataa tgaggaaatc cccatcttcc 2986501 cgcgcccata ttcgacatcc tccgcatttg aagccttaac aagtctgatt tccgggagaa 2986561 tttgattaag caggcctgta aaacgagccg tttcatcttg cgtttcccgt gaaatggaga 2986621 acattttccg tccaatcggc accaaaataa gagcggccag cggaacgacc actaacacaa 2986681 gcagtgtcag cttccagttc ataataaaca agattgtcaa tgatccaatg acagaaatga 2986741 tgcctgtaat aaatccgctg atatgggttg taatcaattc tttgaccacc atcgtatcgt 2986801 tcgttacacg gctgactgtt tctccggaag catttgtatc gaaataagag acaggcagct 2986861 taattaattt cttccataat aactcccgca gcccggaaat gattttttgt ccattatagt 2986921 taagcgcata ggtggcataa gcgcttaaac ccgcctgaac gaaaaacacc agcgcgatca 2986981 aaccgatttg cgtgcctgac agatttgaca tagaaaaacc atcgacaagc tgcttcgtta 2987041 ataatggaat gagcaggctg accagcgtgg ttactacact gagggcaagc gcaaaggcga 2987101 gctttccata agaaggattg gtccgtctta ctaaggcaaa aaagggtttc aatttacttt 2987161 tagatttttg tttcttggtt ggcatatatt ttcctcctgt ttcagcgttc agaaaggtga 2987221 aaagtcatag caaaaggatg atttttactc tttctcaatc atatcaatgg agaaagactt 2987281 tttcagtata tttttgccgt gatcaaaata aaaatctccc actcattgtt tgaataggag 2987341 atttttgtgt tagacatctt tcactggctt cttttttctg taagtcaatg ttacatcctg 2987401 ctgtcgcagg tcttctatta tcattttgta ccgatcaact tttgcggtat gttcttcttt 2987461 tatcatctga agggcagctt ttcgtttttc gctattagac tcaagctctt tttttatttt 2987521 ttttacaatc aacccttttt gccctttgat ttcctctttt aatgaagact caaatttctt 2987581 tgtcaggctg agaaagtcgt tgatcggttg attgagggtg cccgctttcc ccttcatttc 2987641 atcttgggta agaaacatat aggtcgttga tacaatttct gtttcacttt ctgaaaataa 2987701 ggaagtcact cttcatattc ctcctaagac tgaaaatcaa ataactgaga aatcatttct 2987761 tctttttcaa acagcttttc aatactctcg cggatatttt tgataaaatc tcttttttct 2987821 gttgtctgtt tttttaattc agcaacaatt ccatcatttg caggaagcgc acctgtgtgg 2987881 aatgattcat gaactgagat tttctccaat ttatcgaatg tgtggctgaa accagctgca 2987941 agccggaatt gaagatcgaa ggcataatgc gaagggtttt cttccatatg atgaatagcc 2988001 gtgatgatcg cctgcttttt gtctatgaag tcttcatcga tttcctgact gtaaaccttc 2988061 tggtacttag aaatcgcatc ttccatatct tcaacgattt tcataccgtt ttgatagatt 2988121 ctgacagcgg atgagagatt gacttgaatc gtttctcccg agccactctt ccctgtaaaa 2988181 taaatatcgg agcctttata gctgaagcct ttttcctttg acaaggcgtt gagcatttga 2988241 acgatgctgt ggccgtcgac gataagtttt agtgcgtctt ttgtttctgt gtcgagtgtt 2988301 ttcaatgagg acagaattga ttttacatag tccactattt caccaacgtc ttttaaagct 2988361 tgcataaatt ggccatgttt tagatggtct atgaaatgtt cgtaccgtga ctctatgcct 2988421 cgcatactcg cattaatatt cgttaattct tttttgatga ctttcttttg cgtttcatca 2988481 atataaccat tttcagctaa ctgatctacg accggtccgc tgtttctcaa caaggtatga 2988541 agaaaaccta aaaacgacgg cagttcctct tttattcggc catacatttg cttaacatca 2988601 tcaaaatgct catataggac acttactttc tttaaagcgc cgtctgtgtt tttcactttt 2988661 tcaatcaggt ctatgtctat cccgctggct gcctttataa aaccgttcaa gccgtctttt 2988721 tcatagtcat ccttatattt ttgaaggaat ttttgaattg acctcacatc ttcgtcagga 2988781 accccatcca taatgtttcg gatgcctttt acacttgtat ttgtatctgc catcttcaca 2988841 tcaccgaatg taataaaatc ggccttgccg ctgactccat acagcgggtc atcttttgag 2988901 atgcgctgag tgatgtttgt tgttacgcct ttgtcttcat aatatttttg gatttctttt 2988961 tttaactttt ctggcgggat ggaatctata tcttcatatt tataactaaa tttcctaata 2989021 acatatctat ataaactttc atcagtttca agtaattgat caatattgac ttgagctcca 2989081 tttaccccat aaacttcatc atattctcca tcaatcaatt gcaccataac ttggttatta 2989141 tttgcaagtg aatgtcctaa ggcgaatgtt tttaaatcct cagagttacc tgctgctttc 2989201 tttgctttgt tagtaaactc ctttgtagcc tcatactgac tatgatcaat tcctaaaaaa 2989261 agaccaaaaa agttatatga ccaatcctta ttatcggcac taccttctga aataatctga 2989321 agctgatcaa tatgtttttt ctcatctatt atatggattg ccgttccatc gtaacctgat 2989381 tctctggtcg aactttgtat acttgtattc tgatttacaa gttcattgga ggtgtaaatt 2989441 tcaattttca tattctcagg aagatcgtgg tgggtttcct ctttataaat tctgcgtata 2989501 tctgcttcga aatccttctt agctttctta acttcactcg caatagttga ggcaaacttt 2989561 tgtttatagt catattctaa atcaattaac cttaacttta cgttctcatt ctcaaataca 2989621 tttttatttc ccatcttatt tctccttttt atctattaaa aaggtgatag aattaattaa 2989681 tttctcaact ttatttttag ccttttcttc atctaaggag catggttgat tttcattttt 2989741 gcatccaagg gtaaaggcgt attctactcc taggttatct tcctctgtag acttaacata 2989801 tccaaaataa ctgtatgaat aattatattt tctatcaata tcgtcaaaga tgtctttttt 2989861 cttggcagtg taaatatccg ttttcttttt gctgcttttt ttgtattcgc ctttataatc 2989921 attttttcca ctaacaatat ctagcattgt cttaggttca ttcgcaaaac tttcttcttt 2989981 gtaatatgtt acatggccat caaacattac attggtgtct ttatcataac tattaaatcc 2990041 aatactttct ttgtttttcc cggttaacga tgatcttctt gatagatact ttccatcctc 2990101 cggaaacaac atcctaaacc ctttcagctt agattccagc aaataatatc ctggttcctc 2990161 ttcttttgtt gacaccatgt actctctcgt tttctcgtcc tgaaacgcag gtacttgagg 2990221 cagatccttg ggatccatgt cttttggttt taccgcttct gttttattgt catttgtgct 2990281 gtttttatca ttgtcattca tactgcatcc tcctgtcagg gcaagtaata agctgaagca 2990341 aataaagatg atctttttca ttacgaacct ccacgggttt tgtgagaata gtattctatt 2990401 tttatatcaa aaataattct attgacctgg ttaagagatg attatttcat cctttttcat 2990461 gttacatcat ggcggaattt ggataaatag gaaatgagac tcggttttga tctcctttta 2990521 ttaactaatc atatataaca cccaatataa atctaaatac ctattacttt tttcacaaaa 2990581 caaaaagagc cgtatcatcc ggctctttac tcttcaatct cagaatggcg ttttttcaat 2990641 acgtcaagca catcatccag cggcagggat tgttctctga gcaggacaag caggtgatac 2990701 agcaggtctg ccgcttccca tttgagttcc tcatgatccc ggtttttcgc ggcgatgatg 2990761 acttcggatg cttcttctcc gacttttttc aaaatcttat cgacgccttc acggaagagg 2990821 tacgtggtgt aagctccttc aggcatttcc gcttggcgtt ccgcgatcac ccgctccagt 2990881 tcgttcatga tgccgaatcg gtccgcggcc tgttcttctg tttgttcctt tgtaaaacag 2990941 ctgtagctgc cagtgtggca tgccgggcct gacggttcta cgagtacgag cagcgcgtct 2991001 tgatcgcagt cataccggat acctttgacg gcttgcgtgt tccctgaggt ttctccttta 2991061 tgccataacg cttggcgtga gcggctgtaa aaccatgttt ccttcgtttc cagcgttttt 2991121 tcgtacgatt ccttgttcat atacgcaagt gtcagcactt ctttgcttgc cgcatcctgc 2991181 acgatagcag gaattaatcc gtcctcgtta aaacgcagtt catctgcctg tttcatctca 2991241 cattcacccc gtactctttc aagtatgatt tcacttcttt aatcgatgtt tctttataat 2991301 gaaaaattga ggcggccagc gcggcgtcgg cttctccttt tgtaaaagcc tcaagcatat 2991361 gctgtgcgtt tcccgcgcct cccgaagcga taacagggac ggggacagct tcggaaacaa 2991421 gctttgtcag cgtgtggtcg aaaccttttt tctcaccgtc ggagtccatg cttgtcagca 2991481 atatttctcc tgccccgcgt ttgacgcctt cttttgccca cgcggtgacc tcccaatctg 2991541 ttttctttct gccgccgtgc gtgtagacct tatatgtgtc agattctttg tcatacttgg 2991601 catcaatggc aagtacgatg cattgagaac cgaaaaactc ggctccttct gtaatcagct 2991661 cagggcggag aacagctgcc gtgttcaccg acactttgtc cgctccggca cgcagtatcg 2991721 ttttcatatc gctgagctga ttgatgccgc cgccgactgt aaacggaatg gcaagcttcg 2991781 cggcaacctg ctccacaacg tcaaccatcg tctttcgtcc ttcgtgcgag gcggagatat 2991841 caagaaaaac aagttcatcc gcaccttccc ggtcgtacac ttcggcgagt tcaactgggt 2991901 caccggcatc cttcaattcg agaaattgaa ttcctttgac aacgcgtcct tctttgacat 2991961 caaggcatgg gataatccgt tttgtgatca tttgcgcttc accctttcaa gcgcctcact 2992021 cagcgtaaac tgattggtat acagcgcttt tccgatgatc gctccagaga cgccgtccgc 2992081 ctcattgcgg gcgagagctt cgagatccgc gacggagctg actccgccgg aagcgatcac 2992141 cgatttcccc gtttccttag caagctcgac cgtgctttta acattggggc ctgacagcat 2992201 tccatctgtc gcgatgtcag taaaaataaa gacttccgca ccttcattgg ctagctcttt 2992261 gcccagttca gttgccttaa gggttgatgt ttcaagccat ccctctgttg aaacaaaacc 2992321 gtttctcgca tccagtccga ttgcaatttt ctcgccatat tgtttcagca tttttttgac 2992381 aaacggaggg ttagaaactg ctgagcttcc caggatcacc cgctcgactc ctgctgataa 2992441 atattcatag acgtcatttt cagaacggat cccaccgccg atttcgactt tcaggttcag 2992501 cttttgcgca atctcaatca catggcggtc attcactctt ttcccttctt tggccccgtc 2992561 gagatcaacg agatggatcc attcggcacc ctctttctca aataactcag ccatgtcgta 2992621 cggtgaatcg ccatatatcg tttccttatt ataatcccct tgaacaaggc gaacacattt 2992681 gccgtttctc atatcaattg ccggatataa tgtaaaagca ctcatttttt caccttctgt 2992741 tctgctgcca ttttcgtaaa ttgggttaaa atagacattc cgaccgtgct gcttttttcc 2992801 ggatgaaatt gggcgccgaa gacgtttctt tttccgacta cagcaggcac tcgtacacca 2992861 taatcggcgc ttgccagaag cgcgttctcc tccatcccgt caatgtaata ggaatgaacg 2992921 aagtaagcgt agccttgttc tgttttagtc agcagcggag attcattatg aaaagaaaga 2992981 cgattccagc ccatatgcgg aaccttcagc ttgtttcctt tttcatcttc tgctttcagc 2993041 ctgactgctt ttccttttaa cagcccgagt cctgaagcgg tgccgttttc ttcgctttct 2993101 tcaaataaaa gctgcatgcc gaggcagatc ccgagaagca gccttccctc tgagaccata 2993161 tcgtgaatca attgatcaag cttcgtgtag cccaaattgt ccatcgcgtc tccaaatgaa 2993221 ccgactcccg gcaaaatgaa agcatcagct tctttcagct cctccggctt ttcagaaaca 2993281 aaatacggca cgccgacacg ttcaagcgcc tttgagacac tgtataaatt ccccattccg 2993341 taatctatca cgccgatcat ttacagcatc cctttcgttg acggtattcc tttaactcgc 2993401 ggatcgatcg ttgtcgcttc atcaagcgca cgtcccagtg ctttaaaaac ggcttcaatc 2993461 atgtggtggg tatttgttcc ataatgaacg atgacgtgca ggttcattcg agcttcgagc 2993521 gccagcttcc acaaaaattc atgtacaagc tccgtatcga aagttccgac tttagcagcc 2993581 gggaaatcag cgcgcatttc taagtgcggc cggttgctta aatcaatcac aacttgagca 2993641 agtgcctcat ccatcggcac aaacgccgat ccgtagcgtt tgattccttt tttatcgccc 2993701 aacgcttcga gcagcgcctg ccctaagcag atgccgatat cttcagtcgt gtggtgatca 2993761 tctatatcaa catcgccttt tgcgttaatg gaaagatcaa attggccgtg tttcgtgaat 2993821 aaatccaaca tatgtgtcat aaacggcaca tctgttttaa tatccgcttg tcctccgccg 2993881 tctattgtaa atgccagctc aatatctgtt tcgtttgttt tcctgacgcg ttccgctttt 2993941 ctcatttaga aatcctccgt tctctcgctt caattgatct ggcatgggct tctaaccctt 2994001 ccagtctggc aaaagccgcg atgctttcgg catgttcttc aaaggctgat tgactgtaag 2994061 aaataatgct cgatttcttt tgaaaatcag ttacgtttaa tggacttgaa aatctggctg 2994121 ttccgtttgt cggaagcaca tggttcggtc cggcaaaata atcaccgaca ggctcagggc 2994181 tgtatctgcc taagaaaatt gcacccgcat gtttgatact gccaagcaaa gcttccggag 2994241 actgtgttat gatttctaaa tgctctggcg cgagtgtatt gacagtctca atcgcttcta 2994301 ccattgtttc cgccacatat atacaaccgt aatctctcac tgaagcttcc gctatttctc 2994361 ttcgcggcaa ggtttccagc tgcttattca cctcggctga aaccgtctcg gccagcgcca 2994421 tggaatctgt gacaaacaca catgagctaa gcttatcgtg ttccgcctgt gacagcagat 2994481 cggctgcaat ttcgctcgga atcgctgttt catcagccag cacgacgatt tcactcggtc 2994541 cggcaatcat atcgatatcg acatcgccga acacttctcg tttggcaagc gcgacataaa 2994601 tgttgcccgg acccgtgatt ttatccaccg gctcaatggt ttctgttccg tatgctaacg 2994661 ccgcaatcgc ctgagcgccg cccattttgt aaatgtcttt tatgcccagc tcggctgcag 2994721 caaccaaaac tccaggagac agcagaccgt cttttcccgg aggcgtgacg agaacgattc 2994781 tttcaacgcc cgctacgagc gccggaatca cattcatcaa aacagatgaa ggatatgcgg 2994841 ccgttccccc cggcacatat acaccggcgg aatccagcgc cgtcactttc tgccccagca 2994901 ttgtgccgtc ctttctgtga taaaaccagg aggattgcag ctgtctttcg tgatattccc 2994961 taatattttc gattgcctgc ctaatcacct gaagaagacg tgaatccagt gaggtgtatg 2995021 cctcctcaaa ttcttctttt gtgaccagcg ggctgtctat ttcgatgcag tcaaatttcg 2995081 ccgtgtagct gcgaaccgcc tgatcaccgt ttgctttaac atcttcaata atggaccgga 2995141 ccgtctttct ttgctcttcc gttccggcat cgatggaacg cttgagagaa agccgttccg 2995201 ctccgctgat ggttttgatc ttcattttgc cgtctctcct tccacaacga gagataggcg 2995261 ggatgccatt tcgtcaatca catcgtcttt catgcgatag cttaccgggt tgacaataaa 2995321 gcgagaggta atgtcacaaa tgtgctccgt ttcaacaagc ccattttctt tcagcgtctg 2995381 tcctgtggaa acaatgtcca ctatccgatc tgcaagccca atgagcggag ccagttcaat 2995441 tgaaccgttg agcttaataa tctcgacttg ttctccctgc tctctgaaat aactggaagc 2995501 cacattcgga tactttgtcg cgattcttgg cgctactccg ctccagtctg tattcggaag 2995561 tccggcgaca gctaagtggc atttgctgat gtttaaatcc agtacctcat acacatcgcg 2995621 ttcctcctcc agcatgacat ccttgcccgc aattccgacg tctgccacgc catgctccac 2995681 atacgtggtt acgtccatcg gcttcgctaa tataaaccga agattttcct ccggcacatc 2995741 gatgatcagt tttctcgaat cttcaaactc ctcagggagc ctgtagcctg cctgcctcag 2995801 cagccctgcc gcttcttcaa atatccggcc ctttggcatc gccattgtga gtaacttacc 2995861 cattttgctc ttcctttctg gcaccgataa aataagtgac gtttgcaaaa gattttgtca 2995921 tctggtcgat attttctatt cccgataaat cttgaagaac cactttgttc cctttcatgc 2995981 gttcttcatt cgcataagcg atggcttgcg cccgctgctc tttgctgaaa ataacagcgt 2996041 ctatttcaca aggttcgtcc ttcatatgaa gggcttcaat cagccggtcg atccgaagcc 2996101 cgaagcctgt tgccggtgca ggtgaatcaa aatggcccag cagcttgttg taacggccgc 2996161 cgcttccaat gacaaaaccg acattctcgg cgtacacttc aaataaaatc cctgtgtaat 2996221 agctcatgtg gctgaccata ttcagatcca ggcggacatt ttccgtacat ccgtaatcct 2996281 caagaatgtc ccacagcgcc ttcagctcat caaccacgct ttttccttgc gcagaatcga 2996341 cgatttcctc ggcacgtccg catacttcta taccgccccg cagttcaagg agctcaagca 2996401 gcctgctttt atcaatggag gaaagcggga gagacttgac atgctctctg tagccgacgt 2996461 agttcttttc atataagaac ctccgcagca catcagctcg ttcaacgttt ccgagcacct 2996521 caacaaacaa agcatccgca atgccggcat ggccaattgc aattttaaag gatgccagcc 2996581 cagcgttttt taatgccccg acgactaaag caatgacctc cgcatccgcg ctcgtcgtgc 2996641 cgtcaccgat taactccact ccgacctgct cgaactcagc cggacgtccg ccttcacgct 2996701 cctgagccct gaatacattt gccgcatagc cgactcttag cggatgaccg tgtttcagaa 2996761 gcttcgatgc cgccaccctt gcaatcggcc ccgtcatatc cgggcgaagc accaatgtct 2996821 tgccgtcctg atcaagtagc ttaaacagct gctgctcttc aattgctgac tggacgccaa 2996881 cggtatcgta aaactccagt gtcggcgttt ccataaattg atatccccat ttatcaatca 2996941 aatcggttaa cgatcgtctc accttttttt tcgtttcgta taaaccgggc agtgtatctc 2997001 tcatgccgtg cggtttttca aacataaaca tcaacccgag cacctccgct gttatcttat 2997061 gaaggaaaat tccgaatcct ttagttcgct aatatgataa tatgttagca gatgaaagaa 2997121 tgaaaatcaa cgcttaactt cagtaaggat atttttagtt caaatatcct tctcctcatt 2997181 atgaaaaaat catgaataat gtattaaagg tacgtaatat ctcaaattct ttatgtttgg 2997241 catgctataa tacaaatcaa atagagaaca aggagataaa gatgaaaaca ctgcgaactc 2997301 tatgtgtcct gatgattctt tcaggcgtta tttttttcgg acttaaaata gatgcaaaag 2997361 atatagatat tccttttttg aacagcctta aaaaagtggt ttctgatagc gatacagact 2997421 cagctgcgaa tagcaaaaag gagctgaagg gaagcgcaaa accgctggat gtcatccttt 2997481 acaatcaaat ggacgcaccc cggctctata acggctgtga agtaacaagc cttgcgatgg 2997541 tgctgaatta tgcgggatac gacgtgacaa aaaataccct ggcaaatcag gttgccacag 2997601 tgcctttgac atacagcagc ggattaaagg gtgatccgaa tgacggattt gtcggggata 2997661 tggcgaatgg ccctggtctc ggtgtctacc atcgaccgat ctatcagctg gcgaaaacct 2997721 atgcgggaga caaagtgtct gatctgactg gaaaaagtat ttccgctgtt tatcagcagc 2997781 ttgaaaaagg caatccagtt tgggttatta cgacagccaa ctttacgcca gttgacaaca 2997841 tgcagacatg gaaaacgcca aacggaacga tagaaattac gtacagcgaa cacagcgtcg 2997901 ccgttacggg atatgatgat aaatatgtgt atctcaatga tccgtatggc tataaaaaca 2997961 gaaaaaccga tagaacaagc tttgaaaaag cgtggaaaca aatgggcagc caggccgtgg 2998021 ttattcaaaa gtaaacacct gaagcctcac tatgctctat tctgagcaaa tacgacaata 2998081 ttcatgcttt ttgtatcaat cggtaagatc gattcatttt ccatttttca cccaaaattg 2998141 tctttacttt caggctgtct gtttttatga ttaaagcaga ttcagccttg ccccgatcta 2998201 tgcgagagaa gccggtgcaa gtcgctgacg cttctcttgc aaaaaatgaa agatatccgg 2998261 ggaggattta tcattgaaaa aaatcgtgtc tatcctattt atgttcggtt tggttatggg 2998321 tttcagccag tttcagccat caaccgtttt tgcagctgac aaagtggtgc acgaaacaat 2998381 tatcgtacca aaaaatacaa catatgacgg gaaaggacag cggtttgtgg cagggaaaga 2998441 attaggtgac ggaagccagt cagaaaacca agaccctgtt tttcgtgtgg aggatggagc 2998501 aaccctgaaa aatgtggtgc ttggtgcacc tgcagctgat ggcgtgcaca cttatggaaa 2998561 cgttaacatt cagaatgtga aatgggaaga tgttggtgag gatgcgttaa cggtgaagaa 2998621 ggaaggaaaa gtgacgatcg acggcggttc tgctcaaaaa gcgtcagata agatattcca 2998681 aatcaataaa gccagtacct tcacagtgaa aaatttcacg gcggataatg gcgggaagtt 2998741 cattagacag cttggtggtt caaccttcca cgttgatgtg atcatcgaca agtgcaccat 2998801 cacaaacatg aaggaagcga tattccggac ggacagcaaa acaagcacgg tcagaatgac 2998861 aaatacacgc tactctaatg tcggtcaaaa atggattggt gttcagcata tttacgaaaa 2998921 caacaacact caattttaac aaaaaaagtc cgctgatgtt attcagcgga ctttttcaat 2998981 ctttcttgca tttcttcctt cgtatagatg atcctcatcg gatttccgcc gacaaatgcc 2999041 ccgtcaggca catccttatg gacaagcgtt ccggcggaca caactgcgcc atctcctatt 2999101 ttcaccccgg gcagaatggt cgtgttggca ccaatcatca cttcgtcccc gatcagaact 2999161 ttgccgatcc ggtattcgtg aatcaaatac tcatgggcca gaatggtcgt attgtacccg 2999221 atgattgtat ttgttccgac tgagatcttt tccggaaaca tgatatctgg catcaccatg 2999281 agggcaaagg atgtctgttt tccaaccttc atccgcagaa atgtgcggta cagccagttt 2999341 ttcatcccta taaacggcgt atatctcgca atttgaatga caatgaaatt tttgacgacc 2999401 tttaaaaaag gtaccgtttg atagacatgc cacagtgagt tggcccccga gaccggatga 2999461 cgatctgttt ttctcacaga ttacttcact ccaacgattt gtaatagatc actcattttc 2999521 tcaagcataa aatccggctc atgcttcgcc agcatttccg gccctttaat cgtccatgcg 2999581 actcctgccg tttttgtacc ggcgtttttc cctgccagca catcatggta attatcaccg 2999641 accataatgg cttccgccgg ctcgcttcct agctgtttca gcgctaacag cacaggctcg 2999701 ggatcaggct ttgcattcgt cacatcatca agggtgacaa ctgtttcaaa gaattcgccg 2999761 attcccgtga gcttgaggcc catattgaca gtatctctta attttgttgt cacaattcct 2999821 aatgtaaagc cggctttttt taatgcatcc agggtctcat ataccgtttc atattcagtg 2999881 acgagtgaat catgcatgtc atgattgtac gctctgtaca tagcgatcat atcctcgcat 2999941 ttatcagggt ccatcgaaga gaacgtatca aaaagagacg gcccgataaa tgcaaggaca 3000001 tcttctcgtt tatacttgct cggataataa tgctccagtg tatgcaaaaa ggacgcgata 3000061 attaattcat tcgtattaat aagcgttccg tctaaatcaa acagaatcgt cgttacttgt 3000121 ttgtcactca tattgcttcc tttccaaccg ctgagggttt ccattttttc cacgtgtgcg 3000181 caatagccat tgtcagcaga actgctgtgg tgacacgaat caaaagaagc ggccagaccg 3000241 gtatgccaag cggaataaag acaagtgtat cttccacgac cgcgtggcag gcaacgagaa 3000301 atataaatgc caatgtcatg tcccgcttgc tcacgccgtc atcctcgaca gctttgatca 3000361 tgacacccgc tccgtaggcc agaccaatcg tcagtcccgt caccatcgtc atagacgtat 3000421 ttttattcat gccaagcagc tgcgtaaacg gcgacagcca cctggaaaac cgataaagcc 3000481 agcctaaatc tcttaaaaac tggatgataa tcatcagcgg gatcactatt gccgccagct 3000541 gcaaaacacc aagtccggct ttcgttaatg cttctgccaa cattcctagc cagctgtctg 3000601 gcgccgcgct cttcgcagcg ataaaaccgt actgcgccgt ttcctttccg ccatgccaaa 3000661 tgaggttgat gacgatggct gacacagcgg ccaaaccgat gcgcacggcc aatatgacgc 3000721 caattctgat accaaccttt gcggcaactg tcgattcgat aatcaagtta tgacagaaag 3000781 aaagcataac agctaaaata aagacttctt tcacagataa atccaatgtt aaaatcccgg 3000841 caattcccgc atacagattc agcatatttc ccagtacaag cggaatggcc gcttcaccag 3000901 aaagcccgaa gagacccatt accggtgtga tcagccgtac aagccaatcc atgacagggg 3000961 tatgctggag caaagtgacc aatagcgtta ccgggaaaat cactttaccc agcgtccatg 3001021 ttgtttgaaa acctgctgca agaccggcca gaaagatctt cttcatccct catccccctt 3001081 tgttgacgtc tactccgcgt accgctcctt cgagtatccc ttgacgcgtc tgaagatgat 3001141 ggctgccaca gccaaaacaa tcaatacgat tgaaatcacc tgagcgatgc gaagtgaatc 3001201 agtcagcatt aagctgtcag tccgcattcc ttcaataaag tatcttccga ttgaatacca 3001261 aatgatatag atcaagaaca tctcgcctct acgcaaattc gctctgcgca gcagcagtaa 3001321 aacaatgacg ccgacaaagc tccatagtga ttcatataaa aaagtaggat gataatattg 3001381 cccattgata tacatttgat tgatgataaa ttcaggcagg tgcaggtttt ctaaaaaggc 3001441 tctgctgaca gcctcgccgt gcgcttcctg attcatgaag ttcccccagc ggccgatcgc 3001501 ctggccgagc aaaatgctgg gcgcggcaat atccgcaagc ttccagaacg aaaggttttt 3001561 cactctcgaa aacacataac ccgttaaaat ggcgccgatt aatccgccat gaatggcaat 3001621 gccgcccttc caaatcttaa tgatttctcc cggatgtgcc gcataatagt cccattcaaa 3001681 ggcaacataa taaattcgtg cgcaaataat cgcaattgga atggcaaaca ggacaagatc 3001741 aataaacgta tctttctgca gcccccgttt ttcactttcc ctcatcgcta tccacagccc 3001801 gagcaaagcg ccgagaccga taatgattcc gtaccagtgg acggctaacg gccccagctg 3001861 aaatgctatc ggattgagtg gttctatcgc ttcattcatt taacgccaac tcctattctt 3001921 cttgttcacc gtcttcaatg acgtccgcca gcttgttggt aaattgttca gcggcattca 3001981 gccccatccg cttcaatctg aagttcattg ctgccacttc gatgatgact gcaagatttc 3002041 ggcctgggcg gacgggaatc gtcagttttg taatttctgt atcaatgatt ttcatggtct 3002101 cttcctcaag tccgagccgg tcgtattgct tgccctgctc ccagagttca agattcatga 3002161 caatcgtgat tcgtttattg cttctgaccg cgccagcgcc aaatagcgtc atcacattga 3002221 taatgccaag gcccctgatc tcaagaaggt gctcaattaa ttccggagcg tttcccacaa 3002281 gagtatcctg atcctcctgc cgtatttcaa cgcaatcatc ggcaacaagg cgatgccctc 3002341 ttttcacaag ctctagcgct gtttcgcttt ttccgacgcc gctttttcct gtgatcagca 3002401 cgccgacacc atatatatcg acaagaacgc catgaattgc tgtggtaggc gccagcctgc 3002461 tctcaaggaa gttggttaaa cggcttgaca gtcttgtcgt tttcagcggc gatctgagga 3002521 caggcacccc atttttctcg gaggcgtcaa tcagctcctg cgggatgggc atatctctag 3002581 aaagaataat agctggtgtt acatcagtgc acagagaatc cattcgctgc tttttctcct 3002641 cttcaggaag ctgttcaaag aaagaaagct ctgtttttcc gagaagctgc acgcgctccc 3002701 tcgggtaata tgtaaaatat ccggcaattt caatacctgg tcttgatagg tcactcattg 3002761 taatcgggcg gttaattcct tcttctccgc tgattaattc caaattgaac tgttccatta 3002821 cgtcttttgt gcgaaccttt gccacgatat gttcctcctg ttccgggctg ccccgagctt 3002881 gctcacaata ctttcatttt atcactttcg ggcttgaacc taaaacagat tttataaaag 3002941 gggggaaaac acctcagctg gtctagatca ctagtctgaa aaagagtaaa ataaaggtat 3003001 tcaaattcca gaaaggcgga tcatctatgg cagagagtct tcttatcaaa gacattgcga 3003061 tcgtgacaga aaatgaagta atcaaaaacg gctatgtcgg aatcaatgac ggaaaaatca 3003121 gcacagtttc aacagaacgg cccaaggagc catattcaaa agagattcaa gcacctgcgg 3003181 attccgtttt gcttcccggc atgattgaca ttcatatcca cggcggctat ggcgcagata 3003241 caatggatgc tagcttttcc acgctcgaca tcatgtcgtc aagactgccc gaagaaggca 3003301 cgacgagctt tttagccaca acgattaccc aagagcatgg gaacatttct caagctttgg 3003361 tgaacgcaag agagtggaaa gcggctgaag agtcctcttt attaggtgca gaactgctcg 3003421 gcattcattt agagggcccc tttgtttcgc ctaaaagagc cggagcgcag ccaaaggagt 3003481 ggattaggcc ttcggatgtt gagcttttca aaaagtggca gcaggaggcg ggcggactga 3003541 tcaaaattgt tacacttgcg ccggaggagg atcagcattt tgaactgatc cgccatttga 3003601 aagacgaatc gattatcgca tccatggggc acacggatgc cgattccgca ttgctgtcgg 3003661 atgccgcaaa agcaggggcg agccatatga ctcatctgta caacgcgatg agcccgtttc 3003721 atcaccgaga gcccggagtg atcggaacgg cgctggccca tgatgggttt gtgacagagc 3003781 ttatcgccga tggcattcac tcccatcctt tagctgcaaa gcttgctttt ttggcgaaag 3003841 gcagcagcaa gctcatttta attaccgatt ccatgagggc aaaaggactg aaagacggcg 3003901 tatatgagtt cggcggccaa agtgtgacgg taagaggacg aacagcactt ctttcagacg 3003961 gaacccttgc cggttcgatc ctcaaaatga acgaaggcgc acggcatatg cgtgagttta 3004021 caaattgctc ttggacggat atagctaata taacttctga aaacgcggcc aaacagctgg 3004081 gcatctttga ccgaaaaggc agtgtgactg tgggaaaaga tgcagatttg gtgattgtca 3004141 gcagtgattg cgaggtgatt ctcaccattt gccgcggaaa cattgcattt atatccaagg 3004201 aggctgacca gatatgaaag taatggaatg tcaaacgtat gaagagctaa gccaaatagc 3004261 agccagaata acggcagata caatcaaaga aaaacctgat gctgttctcg gtttagcgac 3004321 gggcggcaca ccggaaggca cgtatcgcca gctgatccgc ctgcaccaaa ctgagaatct 3004381 ctcatttcaa aacatcacta cagttaattt ggatgagtac gccggacttt caagcgatga 3004441 cccgaacagc tatcacttct atatgaacga ccgttttttt cagcatatcg acagcaagcc 3004501 tagccggcat tttattccga atggaaatgc agacgatttg gaggccgaat gcagacggta 3004561 tgaacagcta gtcgattccc tcggcgacac tgacattcag cttctcggca tcggccgaaa 3004621 cggacacatc ggctttaacg aaccgggaac gtctttcaag tcgcgaactc atgttgtgac 3004681 attaaatgag caaacccgcc aagcgaatgc cagatatttt ccctccatag acagcgtgcc 3004741 gaaaaaagca ctgacaatgg gaattcaaac gatactctca agcaagcgca ttctgctgct 3004801 tatttctgga aaaagcaaag cggaagctgt tcgtaagctg ttagaaggaa acataagcga 3004861 agattttccc gcatctgctt tgcacctgca ttccgatgtt acggttttga ttgatcgtga 3004921 agccgcgtca ttaagacctt gaaaggaaca tgctgactta tgaatatcaa taaacaatcg 3004981 cctattccga tttactatca gattatggag caattaaaaa cccaaattaa gaacggagag 3005041 ctgcagccgg atatgcctct tccttctgag cgcgaatatg ccgaacaatt cgggatcagc 3005101 cggatgacag ttcgccaggc gctttctaat ttagttaatg aaggcttgct ctatcgcctg 3005161 aaagggcggg gcacctttgt cagcaagcca aaaatggaac aagcacttca agggctgaca 3005221 agctttaccg aggatatgaa aagccgcggg atgacaccgg gcagcaggct cattgattat 3005281 cagcttattg attcaactga ggagctcgcg gctatattag gctgcgggca cccctcctct 3005341 atccataaaa tcactcgggt gcggctggca aatgatattc cgatggcgat tgagtcctca 3005401 catattccgt ttgagcttgc gggtgaattg aacgaatcgc attttcagtc gtcgatctat 3005461 gatcatattg aaaggtacaa cagcataccg atttcccgtg caaaacagga gcttgagcca 3005521 agcgctgcca ccacggaaga agcgaatatt cttggtattc aaaagggagc gcctgtccta 3005581 ttaattaaac gaacaacata tctgcagaac ggaactgctt ttgagcatgc aaaatccgta 3005641 tacagaggcg accgttatac atttgtccac tatatggatc gtctttcata aaaaaagcct 3005701 ccaacccttt ttaaggattg gagacatggc gaaaatcaaa ctggtctggt gccggacgat 3005761 atgtttcttt tttcgtcttg aacttccaga tcggtgattt cgttttgccg ttaaaactgt 3005821 cttccactat aatgtaccaa taataaacag actgcggttc aagatgatcc cagcggaatt 3005881 cagctgtgtc cccgctcttc acttgctccc gttttccgag ctcttcattg gtatatacgt 3005941 tacattcaaa ataatcggtt tccacctttt tgattcttgg cttcaaatca agcgaaaggg 3006001 aaaattcatc cttgttgcca taggtatccg tatcatagta gttcttatcc tttacatacg 3006061 gagagtacgt cgatacgtgc accatgtcat tggcttggtc aaattgaagc aaacgcaaat 3006121 acccttggcc gccttctggc ccgccctgat aatcggccag catttgatgc acaagacgat 3006181 ccggtttccc atcaccatca tcatccagct catctgtttt tctcatcgca ctatgataat 3006241 gcccgctcaa caccatcacg acattcgggt tcggctttac gatttctttg aatattttct 3006301 ctccgattgg gcttctgttt ccgctgacca gcaaatactc atgaaaagct aaaatggcca 3006361 tccggtcagg atgcttcttc agcacctgat tcatccacgc gatgtcttca tccgtaatgc 3006421 cccatcccat gtacagcatg atataatcat tgccgttgct agaaatcagg tcataatgtc 3006481 cgcggttatt tttataggaa ccgccataat gaaatttttt atcaaaacga tcgctgccaa 3006541 aatatttgcc aaacgccctg taggagccgt ccttatgtcc gacatcgtga ttgccggcca 3006601 gcacgccgta aggaattccg ctcttatcca gaacggacat tgaccgatca gcgtttttcc 3006661 actgtctgat atcggcggaa tcatctacaa tatcacccgt gtggaacaca tatttgatat 3006721 tgagctgctt ttgattatct tttatccatt cggtctgttt atcaaaaata tgcggatagc 3006781 tttcggcgta atactgtgta tcagacatcc agacaaatgt gtacatatcc ttcgcaggag 3006841 gaatttcatc ctgtacaatc acattcattt tcgactcccg tacaaaatcg gcggcaatca 3006901 cagacgcttt cagcgtaaac ggtttgtcat ccttcgcgac gaagctgtca acaggctgcc 3006961 attcgtttgt ccgataattc caagcataca tcgtcacctt tctccccggc aaagaactgc 3007021 ccttccagac tgattctgcc agatcattct catcaattga tggatcaacc gtcacttcaa 3007081 agcgatgata agggaaaagc tctttgtttt ctgtcgatac tgtttttcca tcagcagctg 3007141 atacccgctc caattcttta ttcgtaaatg gggtctccct ttccggcaca aagcttttcg 3007201 gcggttcagt cagtgacgcg tgcttaaata ttttcacatg attgcgcgct gtatattgaa 3007261 atcccctata aaaaccaaca tccatggcat cattcgtcgg atctttcacc cgtacagaaa 3007321 gcttggcctt atgcgtgtcg gcttcgctgt ctataacctc cggctggtcc ggatgctctc 3007381 gttcggtttt aaatatcctc tcaatcactg ttttattgcc cgcgagatcc gttgctgtca 3007441 cttttagaga atgttttccc ggcaaaaggt cagaagatga cgtatgatat gggagtgtaa 3007501 tgctttctcc atctaacgac gcctccgctt cctcaattct gctccattta tcatacatat 3007561 ccgcctgcag gataaggttt cctttatacg tttgcccctc ggtgatattc ggctcaatgt 3007621 gaggtcctga attatctacc cgtacaacca ggctgacatt ttccttcccg tcgcttgctt 3007681 gaatatggtg agcgccttca gaaagctttg atgtatccca ctccagcagc tgtgatgtaa 3007741 atagtccgtc aggcagattg aactgaaatt gccagctttt attcgagcgc tgattatcgc 3007801 caataaagag ttccttctca ggagacaccc tctgatctct gatcaccgtt ccatccgata 3007861 acaccaatcg ggcgtttttg actaagaagt catcacggtt ttcagccgta tcaaacggag 3007921 acaccttcga acctgaacgt atcgtaatac gctgcagctg cttccctttc cgaagcagtg 3007981 tctctggcaa tggaacagaa taggtgcggt atttatttgt tgtatcatcg aacaccttca 3008041 gcactttgcc ttccatcgtt accgcgtttt taaaataaag gttcgttttc ctcgtatcga 3008101 atgcaaaata tacttctttt tccatcgcgg gctctgtcac ttgttttttc ccgtcaatcc 3008161 atagcttaat gctgtcagct cgcccttctg tcgtggcttt gagaaattga gttcccgaca 3008221 gcgtgtctct gttttcaata ttcatccgca gaccgtgcgc cttgcttgtt tgtttaatat 3008281 caatcatttt gaccggcgtt ctcgcttcat tgatcccgtc cccggccgcc acataatact 3008341 ctagctgatc cttcccgatc aattcaggcg aatacacaat ataatggaag agattatcgt 3008401 tgcggtcttt ttcagcaaga attcgcttaa acggtttgtt ctcatccgtc cggtagtaaa 3008461 aggccactgt tttcactagg cttcggtccc gtatgtcagc ccgcagctca atgctttcag 3008521 cagggcggac aggcttgcgg tcagtcaaat cctcaatgac cggcttttct ttatcgagct 3008581 tgattttccg tttctggtcg ggcacctgtg cctgtaatac ggttccggga gacggattct 3008641 tttccccgat tgaaatgttc agaagttctg ctgttccgtt cagtggatac ttataaagca 3008701 ctgatgacag ccggcgcagc gcatgtttcc gataatgcgc aaccgaaatg tcctttcctg 3008761 tattcgttga tatcacaacg gcccgcggcc tcgtattggc cataccctct gtctcgtcta 3008821 tcaccgcaag attttttcct tcttttagtt gtgtctgata ataacgattg aaatccgctg 3008881 acgtcaattc tggatgcccg gcaggcttca gccagacgac aaacgtttcg ccggatggta 3008941 tcaagatcct ttcatcaggt ctccaaatca gatcggagtc aggcccttct tttgggtagc 3009001 ggtaacggat atggtagtct ttaaaatcaa tcgttctgtc agtcgtatta aaaatctcaa 3009061 taaattcata accgtctgcg cgtcctatat tcttcgtatc aaccgccagc tctgtgatca 3009121 gaagctccgg aatatgggca aggtcagcct ggtatccttc aagcttcagt ttcttcgtct 3009181 ccgactcaac ccgctgcttc ccattcgaca tcacaatgta atactcaagc tcgctgttcc 3009241 aaatcaaacg tttcggaatt tgtgccaaaa acttgcggac cgctccgggg gtcgggtcca 3009301 tcggcaccat tttgtagccc agctcattac tttgtttata aaaaagaaag gcggaaaatg 3009361 cttgatacga attatcgcga acttgagcct caatcattag attgcttctc atttcagctt 3009421 tcacatcaat ttgaggagga ttttcaagca agggtatgta atgaggcgtt tgaaatagtt 3009481 cctgctgtac aacaggaaaa gctttcgatt catgatggcc gccagacaaa acggaaagaa 3009541 aagacagtaa tatagaagca ataaccgtgt atttcctcat caaagcacct cccttttcat 3009601 gtattttgcg tctgaacagg gaagcttatg agttcatttt tgtgcataaa gaacaaaaaa 3009661 acgtctgtct cttgaaaatt ccactattac ccagtaaact aaggatagtt aaccagttaa 3009721 caattaaatc agagaggcaa attgatggac aacagcattc atgatgaatt atttcaagct 3009781 atacaacaat tcgcattaaa aagggataaa cgcgtctggc aaaaggtgca gataccatcc 3009841 attggcatat cctcacaaca tcacgatcac ctcaaaaaag actggacttt gacccagctt 3009901 cacattgttt cctgcataca taccagccaa aatgtgaaca acagcttctt agcatcccgt 3009961 ttacacatct caaaagccgc tgtttcaaaa gcggttcatg ctttgttgaa acacaatatc 3010021 attacagtga caaaaaagcc tggcaacaaa aaagaaattt tttatacgct aactgatagc 3010081 ggcagaaaat tggcggcatt acatgaacag cttcatgaga aagcaaagga gcaatataaa 3010141 cagcttttca atgaattttc aattgatgat ttaaaaacag tgactgcgtt tttcaacttg 3010201 tggatcaaat atatgtaaaa agagtctcac ccgcatggga gagacctttg gaattctatt 3010261 atgccccgtc aaacgcaacg agaagtgaaa caggtccgcg tgtatacaga ccggactcag 3010321 cataacaaaa atcttcctct aatctgatat tccgcatctt atccagcaca atattagcta 3010381 caatttcgat ttcgtttttg gcaaaagctg ctcctacaca gttatgaatg ccggatccga 3010441 aagcgagatg ccgggcggcg ccgctaaaag cgctcttgat accaagatct tcccgatgaa 3010501 tattaaacac gtcaggctgt tcaaatgctt cagggtcccg gttagccgca ccgatcatac 3010561 aaaaaacaat cgtatctttt ttgatttcca taccgccgac cactgtatct tgggacagct 3010621 gccgcggaat cagctgaacc ggcggtttat aacgcaatgt ctccgcaatg gctctcggaa 3010681 ctaacgaacg gtcagccaaa acatcattca tctgctcagg attgttgagc aaatggtaga 3010741 tcatcagtgc cagcgtctta tcagccggtt ccgttgcggc taacagcaca ttaagaatca 3010801 gtgcgagtat atccttgtcc gacagcgcca tgccttcata ttcagaagta cataggatcg 3010861 aaattaaatc tgatcccgga ttgacgcgac gttctttaat gaccggcatc aagtattggg 3010921 aaagctgttc gctgcaccat aacgaatgtg cccgcgcttc aggagattga gagatactcg 3010981 tgataaaatc ggcaactccg ctgtgccact cagagatttt ttcatggtct cttttatcca 3011041 gcccgagcat gtccatcgtg acgcacaccg caaacgtctt tccaaaatca ttgacgagat 3011101 cacttttccc tctttcaaga taaggcgcta acaagttttc tgcattttgt ttaatcaatg 3011161 gagacagatg atccagtgcg tcaccgataa agcttctcac tacaattctt cttttggcag 3011221 agtgttcttt tccatgcatt tgggccagca cagggcctcg catgactggt tcggcacgct 3011281 caacaagtga tttcgtcgtg aagatatccg gatgctgaag gatatagcgg acatcatgat 3011341 agcggctgat aaaataactg tctatcgact cttcataatg aaccggatct tcctcccgca 3011401 gttgtgaaaa ataagcatat ggattgtttt gaaattgatc agaaagcaca ctaaacaatt 3011461 taatcgattg gctcatgttt tactccccct atcatccttc agatgtgatc cgtttctcag 3011521 aaagcatctg cgccatttcc tgtacaatga gatacccttg attcggccgc atacaaatag 3011581 aaaattcatg gttactgatc ttctcaccca gcttccacgg acgatgataa gcaaggagtg 3011641 tctcttccac ctctaaaata tccggagctc cgataaaaaa cggcagctca gctatgacat 3011701 attccacagc caaattcagc atatcctcac tgacttcttc catcatcaaa ctgacgcccc 3011761 gcgcacgccc gattatcgct tcacgagaca tgtccaaaca agcatgtcga aaatgaggct 3011821 gctcaaaaaa tgcatgttca acttcttgtc tcaacagctg gtaggctttg ttatctataa 3011881 aatcagaaaa tgtatgaatc gccttcggat ccccgccatg agccacaagg gctctttctg 3011941 caaatctcct gtttcgtgat acctctttcc ttacttttcg ttcagccttt cctctcggag 3012001 ttccaagcgc ttctagaaga ttagccgcct catgccctgc aagtaaaact gaaacgcttt 3012061 taaattgagc tttcgcccat ccaattaatc tgtaaatata atcctctgaa aacctgctgt 3012121 taaatgggct gatccccacc aaaacatgcc tgcgccgttc aaatatttct ctgcagtttt 3012181 ctgttaatgc ctcagcaata aaatgcacag accttctttc cgttaccatt ccggtcatct 3012241 cattcacccc taaaacttat cccgctttaa gtcatcaccc tcaaatacaa gatggaatag 3012301 ctagaacaac tgaacaagac gaatggcagg catcacttaa agtttccaaa tgttttttaa 3012361 gattttaata atcattttca atacccatat catgataaat gtttactagt aaacattagt 3012421 cattttatcc cttttccttc caaacgtcaa tatgatctgt gcccaaatat ttgaaaataa 3012481 atgtaaacat cacattttcc acacactttt tacacgcata ttcagcatga catatcaaca 3012541 aatagtctaa acaccaacaa ttgacaacga aaacaagaaa agataaaata aaattgttca 3012601 ccagtaaacg atttgtttta ttgtttcatc gtaaactatt attcctaaga aagaaggtag 3012661 cctatgtctg atttgacaaa acagatgata tacgacatat acgtgagact gctgcacctt 3012721 aatgaacaaa aagcgaacac ttcacttcag caatttttta aggaggccgc agaagaggat 3012781 gtagctgaaa ttcccaaaaa tatgacaagc attcacgtca ttgactgcat cggccagcat 3012841 gaacccatta ataatgccgg aattgccaga aaaatgaact tatcgaaagc gaatgtaacg 3012901 aaaatcagca caaaactgat caaggaagaa ttcattaaca gctatcagct gacagataac 3012961 aaaaaagaag tttattttaa attaacccgt aaaggcagac ggattttcga cttacatgag 3013021 aaactgcata aaaaaaagga gctggctttt taccaattcc tcgattcatt ttcacaagaa 3013081 gaacaaaagg ctgtattgaa gtttctagag cagttgacgt caacacttga agcagaacaa 3013141 accgatggga ctccagacaa acctgtaaag taaacaaaaa ggcggtgtac actttggctc 3013201 atacaaaatc aaaggcagta ttgatcttat acactgtttg cttcagtgca ttttttgcat 3013261 ctttaagcca gaacatttat tcacctattc ttccgatcat taaagaatca ttccatgttt 3013321 ccacagctat ggtgaacctg tcagtctcag tttttatgat tgtgacagca ataatgcaaa 3013381 ttatattagg agcgatcatt gattttaaag gcgctcggat cgtcttgatt accggtattc 3013441 tggcaacggc agcagccagc atcggctgtg cggtgactac tgactttacc ttgtttctga 3013501 tattcagaat gatacaggca gccggttccg cagcactgcc tcttattgct gccacaacga 3013561 tcggacagct gtttacagga aatgaacgcg ggagtgcaat gggaacgtat caaatgctcc 3013621 tgtctgtcgc accggctatt gctccagttc taggaggatt cataggcgga gcagccggat 3013681 acgaagggat tttttggata cttgcggcca tctctatcgt tttgctggtg acaaacagca 3013741 tcacctttcc taaagattct ccaactgaat ctatgcagca agccaaaggc aatgtgttcg 3013801 ctcattataa atcaatattt acaaatcgaa cagggaacgt cattttgact ttaagttttg 3013861 ttctcttttt catttatttt gcagtaattg tctacctccc aatattgctg acagagcatt 3013921 accatataga tgtgggtata gcaggactgt tatatttgcc gctggcgctg agcacgattg 3013981 caggtacgtt tctgtttaaa agaatacagg caaaaatcgg gctgcacacc ttgtttatcg 3014041 gaagcaatgt gattgccgcc tgcagcatca ttttatttgc tgttacacat tccgtttctc 3014101 tcgttctcat ggctctgacg ctggcactgt ttggcatctc gatgggggtt attcctccct 3014161 tgtactctac aatgattact aatgaatttg agcacaacag agggagtgca atcggaatgt 3014221 ttaactttat ccgatataca ggcatggcag caggtccgat ggtatctgcc tacttgctca 3014281 caatgatgcc gtctgccatg tcctttagcc tcctaggcct tggatttgcc gcattgagct 3014341 tttgccttct tccgccaatg ttttcgccgc agaagcgcac gaaacaaaaa aagcaccaca 3014401 tgtaaaaaag ctgcctttgc gggcagcttt ttttattttt ttctaagcgg ctctaaaatg 3014461 cctttttgaa tcagcaaatg gaagaccgac aggataacgg atgcccatat cgctgtgccg 3014521 aagccgtcga tttgaaagct gtcacccata atggacgcgg tcatcataag cgtgatggcg 3014581 ttaatcacaa acaagaagag tccaagcgtc accatggtga ccggcagtgt aaatataatt 3014641 aaaagcggtt taatcagcac gtttaagatc gataaaatga ggctggcgat aatcgctgcc 3014701 ccaatgctgc tgatatggat ggagtcaata tatccatcaa tgacgattaa taacaatgca 3014761 ttgactaaaa tgctgactgc ccattttacc atgtcatttc atatcccttt ctgacgggac 3014821 gataaaaatc caaatgatat aaatgagcaa aaccggcaag acacttgtca taatggctaa 3014881 gatgacagtt atgactctga ggagtgatgc gtcccaattg aaatattccg cgagacctcc 3014941 gataacaccg gcgattttct tatttttttc tgagcgataa agcttattca ttcgatcacc 3015001 tctgtgagta ctttagtttg atggcgcctg ttagtgattc tgagaagacg gtgatgtttt 3015061 gatcatgtgc ctgatttgaa gtgaacatca tttctttttg aatcgtatca tttttttcct 3015121 tcagcatctc tacatccatt aattcatggg acagcgtacc aagattgctt ttcagctctg 3015181 ccttcactgc gagatcgtcc ggaattgcaa gctctacatt tccagtcgtt gtttttgcat 3015241 aaatggagcg gcagtctgat tctgttacgt taatcgcaat atttccgtta aagctttgaa 3015301 cgtcaatgga ttcgcttttc cctcggagat cgatcaatcc gttaatggtt tccgcttcta 3015361 tcgtaccgca gctgtggctt gcgagcttaa tttgcccgtt ggccgtttca gctatggctt 3015421 tttcggctgt taaatacgag aacgacagca cgccgtttgt cgttttcgct gagaactctt 3015481 ttacatgtaa atgttcccct ctgactggac cgttaaacag cttcacccga atcttatcat 3015541 actccttctg aggaatatac aaagtgacat tcgttttcat cgtctttttc tcagtacgga 3015601 taaaaaactt attacctttg atttcacatt caatatgctg aagaaatgcg tgtctcgccg 3015661 catcctggct gtcagcgcga tataccttcg cctggcattc cgctctgata tcgtcatctt 3015721 cccaagggac gatatttacg ctgccattgg caatttgcag ctcaacactg gaaaagtcag 3015781 tatctttaaa ttgaaaaatg tgctgaacat catacgcatg gccaaagttt aaatcaaggt 3015841 caacttcctt gacctttttc acagcagaat caatccagtc aaacagcttg gctcctaaag 3015901 acggtttgcc gctttctttt tttgccgttg taaatggctc ttcctcgtca tgaacgtgaa 3015961 ctgagagcgc tgtgattttc tcttcttttt ccttgtagtc gctgtcaagc ttttcaatca 3016021 gtgtcaaagc ttcttgtgct gtaagctttc cttcctcaac aagcttaagg attcgttcct 3016081 tttcttgctt cattacgatc tcctccccat tgtctactta tgctgcacgc aggaccttaa 3016141 tgccctgaat cacattccaa atgataatgc caatgacaac taagaaataa ataaccgctc 3016201 ccccgatgat tacaaataca ggaagcaagc tgtctccatc aatcgcaacg gctccgccaa 3016261 gtaaagcaat aaaaaggaac agccagccga caaacggaac aatgtgagaa ataagagagc 3016321 gtatcgcatg gcgttttgtt tctttctcat ttacaacaaa atatgcgaca atcggcacaa 3016381 tgattggcgc aatgaacaca ctgaaataac aaagtgatgc aataatagct tgattacggt 3016441 tcaattcatt ccacactcct attgtgaatt gtccatgaca aaagatcagg gacgttttac 3016501 ttatttatac gtttaaaatc tcttcaggtt tcaaattcat tctttagaca tgctccgatt 3016561 tacggaaatt ggattttaaa aagttttaga agtagaatct tccggctata ccgattacaa 3016621 tatgtaaaaa gcttacggca accaaggagg ctggacaagc aatggagaaa gatcccagtg 3016681 actatacagt aacacaagaa tcagtgttaa agctgattca ggaacaaaaa agaatgaatc 3016741 gtgaaatgat caccgagctt gagcagattc acggaccctt cccgatctct cacgatatcc 3016801 aatatataaa agtgctgctc gacagcagca acacacatat tgttcaagat ttaatgagtg 3016861 taagtaagca gctgtataag aagactttgt aattgcggaa aacatatcat tcattataac 3016921 tgaaacaaag ctaaaggtta gatgacaata tcttgccttt tttgttttga aaaaacaagt 3016981 gattccctgg ctgtcacaaa atgattgtaa caaaaaaagc ctgccggcac atccagttaa 3017041 tggactctgt cggcaagctg taactatcag aaagagatag ccgttcaaaa ttaacgtaac 3017101 aattgaagca cgttttgcgg ctgttggttt gcttgagcaa gcatcgcttg agaagcttga 3017161 gaaggaatgt tgttctttgt gaactcgctc atttctttcg ccatgtcaac gtcacggata 3017221 cgggactcag cagctgtcag gttttcagaa gaagcaccaa ggttgttgat tgtgtgctct 3017281 agacggtttt gtaccgcacc aagtttagca cgttggtttg agacattgtt gattgcagta 3017341 tcaatacttt caagttgtgt atcaaaagga gtattagcaa aatctgttac attaagtgcg 3017401 tttactccta aagcagttga tgacatgctg tcaatgttaa ctgtaagctg ctggccagca 3017461 tttgctccaa tttggaaagt gaaaccatca gtttcagtac catctaataa ctttttgccg 3017521 ttgaattcag tacgatttga aatgccatca acttcctcaa taagcgcatc catttcatct 3017581 ttaattgcac caagatcttc tgcttgttgt gtacctgtgt ttcctgcttg aacagtaagt 3017641 tcacttctaa acctattatg ccgtaaagaa aaagcttgcc tgctaagccc aaggatggac 3017701 ttgccgacaa gctgtcccct cttaacagag ggttttaaga tgtagctgtt tcttttgctt 3017761 tcaagagcga tttcatgcgt gttttgtcac gttcgataac aggctttaaa taacggcctg 3017821 tatacgattc ttcaacttca gtgatttcct caggcgttcc agacgcgaca atggttccgc 3017881 ctccggctcc gccttccggg cccaaatcca caatgtaatc ggccgtctta atgatatcaa 3017941 gattgtgctc aataaccagt acagtgtctc cgttgtctac caaccgttgc agcacgacaa 3018001 gaagcctggc gatatcgtcg acatgcaaac ctgtcgtcgg ctcatctaaa atgtagagcg 3018061 tacgtccggt tgagcgtttg tgcagctctg acgcgagctt cacgcgctgc gcttctccgc 3018121 ctgacaaggt cgtcgccggc tggccgagcg taatataacc taaaccaaca tcataaaggg 3018181 tttggagctt gcgtttgatt ttcgggatat tttcaaagaa agaaagagca tcttcaaccg 3018241 tcatatcaag cacatcagag atgctttttc ctttgtacgt cacttcaagc gtttcacggt 3018301 tatagcgttt gccgtgacac acctcgcatg gaacgtatac gtcaggaagg aagtgcattt 3018361 caattttaat aatcccgtct ccgcggcagg cttcacatcg tccgcccttc acgttgaagc 3018421 tgaaacggcc ttttttatag ccgcggacct tcgcttcatt tgtctgcgcg aatacatcac 3018481 gaatgtcatc aaatacaccg gtgtatgtcg cagggttgga tctcggcgtt cttccgattg 3018541 gcgcctggtc aatgtcaatg actttatcta aatgatccaa acctttaatc tctttatggc 3018601 tgccgggctt cgctttcgct ttatgaagct tttgcgccag cgccttatgc aaaatttcat 3018661 taacgagtgt actctttcct gaaccggaaa cacctgtaac tgctgtaaac gtcccaagcg 3018721 ggaacttggc attcactttt ttcaggttgt tttctgatgc acctttaatt tcaatgtaac 3018781 gtccgtccgg ctttcttctt tcaggaggca atgggataaa ctttttccct gataaatagc 3018841 tgcccgttaa tgaatttgga tcttccatca cttcttccgg cgtacccgca gatatcacct 3018901 gtccgccgtg aatgccggct cccggtccaa tatctattaa ataatctgct gccatcatcg 3018961 tgtcctcatc atgttcgaca acaatcagcg tgttcccgag gtctctcata tttttcagag 3019021 cgctgatcaa gcggtcgtta tcacgctgat gcagaccgat agacggctca tctaaaatat 3019081 aaagcacacc ggataaacgc gagccaattt gagtcgccag cctgatgcgc tgcgcctctc 3019141 ctccggacaa tgtacccgct gccctgctca atgtcaggta atcgaggccg actttgtcca 3019201 gaaagcttaa gcgctccaca atttcgcgca aaatcaaatt ggcgatctgc atatccttct 3019261 cagaaagggt aagatcttta aagaaggcaa gtgcgtcggc gacagacagc tcggtaattt 3019321 tcccaatgtg gcggccgtca atcagtacgg caagcgcctc tttctttaac cgatagcctt 3019381 tgcacgtcgg acaagacttc tgagacatat actgctccat ttgctcacgt atgaaatcgg 3019441 agcctgtctc cttatagcgt ctttcaatgt tgcgcaatac gccttcaaat tgaatttcac 3019501 cttcgcggat ttgtccaaaa tcattttcat atcggaaata aatcaggtca tccccgctgc 3019561 cgtacagcac tttatccagt tgatgcttcg gcaaatcttt gaccggcaca tccatatcaa 3019621 tcccgtagtg ggtgcagact gcctcaagca gctgaggata atattgtgag ctgatcggtg 3019681 tccaaggggc gaccgcattc tccttcaatg acaaatcttg attggggatg acaagatcgg 3019741 catccacttc aagcttcatt ccgagaccgt cacacgtcgg acacgccccg aacggactgt 3019801 taaacgaaaa cagacgcggc tcaagctcac caattgaaaa tccgcagtgc ggacaggcat 3019861 gatgctcgct gaacatcagc tcttcctcac cgatgacatc gatcataacc cgtccttcac 3019921 ctaaacgaag cgccgtttcc aatgaatctg acagccgggc tgccacgcct tctttcacga 3019981 caatccggtc aatgactacc tcaatggaat gcttcttgtt cttttctaat tcgatatcgt 3020041 cggaaagctc agccatctcg ccgtcaattc tgactctgac atagccttgt ttcctaatct 3020101 gttcaagcac tttgacatga gcgccttttc ggcccgagac aatcggcgcc agcacctgaa 3020161 gcttcgtccg ttccgggtat tccagaattc tgtccaccat ttgctcgatg gtctgggatg 3020221 taatctcaat tccgtgttcc ggacaatgag gcttccctac tctcgcatat aaaagacgca 3020281 gataatcata aatctcagtt accgtaccga cagtagacct cggattgcgg ctcgttgttt 3020341 tctgatcaat gctgatggcg ggagagagcc cctcaattgc atccacatcc ggcttatcca 3020401 tttgccctaa aaactggcgg gcataggcag acagcgactc gacataccgt ctctgtcctt 3020461 cagcatatat cgtgtcaaag gcaagggagg atttacctga tccggacaaa cccgtgacaa 3020521 cgacaagctg atctctcgga atcgttacat ctatattttt caggttatgc gccctggctc 3020581 ccttcacctc tatccgatcc atagccattt gttcatcatc cttccgcttt tagctctaaa 3020641 agtaaatcgc gaagctccgc ggctctctca aagtcaagcg ccttggcggc ttccttcatt 3020701 tcatgctcca tctgttcaac gactttctgg cgttctttct tcgtcatttt cgacagcttc 3020761 ggcgcggctt ttgttttgta ttccgcttta tcctcagctg ctactgtggc acgaatgaca 3020821 tcgcgaattt ctttatttat cgttttcggc gtaatgccgt gctcttcgtt aaaccgctcc 3020881 tgctgctcgc ggcggcgttt tgtttcatta atcgcaattt ccatagactt cgttatttta 3020941 tcggcgtaca taatgacgcg gccttccgca tttctcgctg cccgtccgat ggtctggatc 3021001 agcgaccgct ccgaacgaag gaaaccttcc ttatccgcat ccaaaatcgc aacaagggat 3021061 acttcgggaa tgtccaaacc ttccctcagc aggttgatgc cgacaagcac atcgtacttg 3021121 ccaaggcgca ggtcgcggat aatttcaatc cgttcaagcg tcttgatctc agaatgcaga 3021181 tagtttactt taatgccgat ttcctttaaa taatcggtca gatcctctga catcttcttc 3021241 gtcaaagttg tcacaagcac ccgttcattc cgctcgattc ttgcttgaat ttcgccgatc 3021301 aagtcgtcaa tctgaccttc gattggacgg acgtcaataa gcgggtcaag aagccccgtc 3021361 ggacgaatga tctgttcgac catttcatct gtatgttcaa tctcgtacgg ccctggtgtt 3021421 gctgatacat acacgatatt gtgcatatgc ttttcaaatt cctcaaaacg aagcggacgg 3021481 ttatcaagcg ctgatggaag ccggaagccg tgatccacga gcacctgttt ccgcgcctgg 3021541 tctccgttaa acatgccgcg cacctgagga attgtcacat gcgactcatc caccacgatc 3021601 ataaaatcgt ctgggaaata atcaagaagc gtatacggcg ttgaacctgg aggccgcaga 3021661 gtcaaatgtc ttgaatagtt ctcgatgccg gagcagaaac ccatttcacg catcatttca 3021721 agatcatatc ttgtccgctg ctctaaacgc tgcgcttcaa ggagctttcc gttttcatgc 3021781 atgaccttca gctgctcctc aagctccttc tcgatatttt gaatcgcctt ctccattttc 3021841 tcggcccgcg ttacgaagtg ggatgccggg aaaatcgcaa catgatctcg gtcgccgaga 3021901 atttctcctg tcagcgcatc tacttcccga atccgttcga tttcgtcacc gaaaaattca 3021961 actctgacac aatgctcatc acgggatgcc ggaaagattt ccactacatc cccgcgcaca 3022021 cgaaatgtac cgcgctgaaa gtcgatatcg ttgcgggcat attggatgtc tacaagtttt 3022081 ctgagcagct cgttgcgctc aatttccatt tcagtccgca gtgacacgac catttcccgg 3022141 tattcctcag gcgaaccgag gccgtatata caagacacac tcgcaataat aatgacatct 3022201 ctgcgctcaa acaaagctga tgtggcggag tgtctcagtt tatcaatttc atcattaata 3022261 ctagcgtctt tctctataaa tgtatccgtt tgaggcacat acgcctccgg ctgataataa 3022321 tcatagtagc tgacaaaata ctcgacagca ttgttcggaa aaaattcctt gaactcactg 3022381 taaagctgtc cagcaagggt tttgttatgg gcaatcacga gagtcggctt attgacttct 3022441 ttaatcaaat tggacaccgt aaatgttttc ccagttcctg ttgcacccag cagagtctga 3022501 tgcttcttgc cctcctgaat tcctttcaca agcttttcaa tggctttcgg ctgatctccc 3022561 tggggctgat atttcgagac taactcaaag cgatctttca caaaaataag cctccgtttc 3022621 tttaacgaaa tcttcctata gatatagtaa cacaatggaa agcaaaatca ctaaaaatac 3022681 gaactaaagt tcggtggttt tttatttcca gctgtttttg tgtataaaaa acctgctttt 3022741 aaaacgtaaa agcaggtatt cagtctttat attcattatg tccgatttat tcttcttttt 3022801 tctctgcagc ttttttggcc atatacagtc cgccagccac aagagacaca acatccaatc 3022861 ctacaataaa atacgtttct gtatagcctt ttaaataaga ggcaaacagc aatgcagctg 3022921 ttaaagcgat cgccacataa tgattaaagg tgactctagt aaatagaaca acaagcataa 3022981 aagggaaaaa caatgcaaaa acggcttttg taatcaacaa aaaccctcct cagggattct 3023041 tcatctgatc tgattatagt aaaaaatgaa gaatcggaca atcgtgcatt cgctccctct 3023101 acttacacca tacccctttt cagccaaaat caatcaccat atttgcattt tggtgccggt 3023161 caaaacttat tccatggtgc cgctgttcta atcagcggca ctttttttat tacatcatca 3023221 agtccgccgc cagattccga gaataaaaga aaataggcat acagtaccag tacggccgca 3023281 tttttcagga taatataacc aacttaacta ttcattttat ttaggacttt ctgcgtttga 3023341 cagcattttc ctgaaaacct acaattaaat gatagtgttt actatcattt tttaaacaca 3023401 ggctccgcaa taaaaagact agagagaaaa acaaaatgaa tgaagaaaag aggggtttca 3023461 aatatgtatt ctgttttatt tcgccaggca gaagagtcca gccagctggc tggagcaaaa 3023521 ggaatgaatt tgattaaatt gaccaaacac ggtcttcctg ttccggacgg gtttattatt 3023581 caaacgaatg cgctcgcacg ttttatggag gacaaccagc ttcaagagac tagtgaaaac 3023641 gtcgaaggcg ggatcatttc cggaacattt tcggatgagc tgaaagatga gctgactagt 3023701 tccttttata agcttagaga atcatatcga tccgtagccg tgcgttcttc gtctgcttcg 3023761 gaagatttag aaggcgcctc attcgcgggt caatatgaaa cctacttaaa tatcaaaaca 3023821 gaggaagagt ttctggctaa agtgaaagaa tgctgggcct catttttttc tgggcgggtc 3023881 agcagctata agaaaaaaat gaacaatcaa atcgcagagc cgttaatggg aatagtcgtt 3023941 caggggctga tcgattcaga aatgtcaggt gttatcttca gccgcaaccc tgttacccat 3024001 gatgatagag agcttttaat cagcgccagc tacgggttgg gtgaagctgt tgtttcagga 3024061 aatgttaccc cagacacgtt cattgttaat aaatcttcgt ttgagattca gaaagaaata 3024121 ggtgcaaagg aaatctacat ggagtctgcg gcagaaggaa ttgctgaaaa agaaacgagt 3024181 gaagacatgc gcagccgttt ttgccttaca gatgaacaag tgattgaatt ggctgaaatc 3024241 acaaaaaaaa ccgaagacct gtacggatat cctgttgata tagaatttgg aattgctgat 3024301 catcaaatat accttctgca agctcgcccg attacaacca ttgatcagga caaaaaagcg 3024361 gcagaagaaa aacgcagctt catgattacc gacactgata tgaatgattt ctggcttaac 3024421 atggagtcta atattgaagg tccggtgagt ccgttatttt catccttcat cgtgccggca 3024481 ttggaatatg gcttgaagaa gagcatgcaa aagtttccga ttggtgtagt tgttgatgaa 3024541 gtaaaacttt atcgcggaca tatttattcc aaaaaccaag gcggacagca gcctccttct 3024601 gaagactgcg gcaaagagct tttcccgatt ttatcggagc atatgtatga catcatcaat 3024661 cacacatacc tcccttttta ccggacactg gaccagctcg cacaaactga gcataccgca 3024721 gaaagcgcac tggaagcttt tcaaaaacta aaggcctttt atctcacggc ttatgaagag 3024781 cactttaata tcgttttccc gcaaatcctt ttaacaaaca aactgcaagc gatgtatcag 3024841 gacattcaag gagagtccga aaacgctcat ttttacgaga tgctgacagg aaaaatgaac 3024901 aaatcactgg aaacggaccg ttgcttatgg ctattttctg tggaagttca ggagaacccg 3024961 aaccttctgg ccatttttga aaacaacaag cctgaacagc tccaggagaa attggaacaa 3025021 acagatgagg gaagacactt cctgaagaac gtccatgaat tcttgcaaga atacggatgg 3025081 agatctgtta aaagtcatga tctgattgaa caaatctggg tggaaaatcc gtatttcgct 3025141 ctggccaata ttcaaaatta tgtccgtaat ggctatcatt ttgacaatga atttcagaaa 3025201 acaaaagaaa aacgagagaa attatacaat gaattcttgg aaagcataga agatcccggt 3025261 ttacgcaccg aatttgaccg ctattatcaa tggacactga actctgcaaa tataaaagat 3025321 gatcaccact tttatattga cgccatgctg gatgccaagg cgagaatctt tctgctgaag 3025381 ataggtgaat tgctggcgga aaacggtgtc attcaagatc gggaggacct ttggttctta 3025441 tatgacgacg aagtggaaca agcgcttctt caccctgtat ccctgcaaga aaaggctgaa 3025501 aaacgcagac agatttttca tgagtatgag ctggcccaag ccccggccta cctcggcacc 3025561 ccgacaaaag aacagctcaa agcagctgaa gaaattgtcg gcgctgtgat agaggatgaa 3025621 aaaaacacag agaatcatat ttttggcatt gcggcatcaa gcggcattgc gacaggtccg 3025681 gtgaaaatca ttcgggacgc caatgaattt tctcaattcg cgcctggaga cgtactcgtt 3025741 tgcaagatga ccacaccgct atggaccagc ctgtttcaag acgccaaagc gattattaca 3025801 gacacaggcg gcattttgtc tcacgctgcg attattgccc gtgaatacgg cattccagcc 3025861 gttctcggca cacgcacggc aaccgaaaga ctgcgagacg gtgacatcat cactgttgac 3025921 ggaagcagcg gcaaaatcac agttgtcagc cggtcctgat gcgtccccct ctttcttata 3025981 caagcggggc gggtgtatac ttgtcctgcc agtatattcg tgaggtgaaa cgtattgaga 3026041 ccgacaaaca agagaatcct tgatgctgcc atgcagctgc tcgtcaaaaa aggatatcgc 3026101 gcaacgacta caaaagaaat tgcagaaaaa gcaaatgtaa gtgaagcgac gattttcagg 3026161 aactttaaaa acaaacaagg actagttgag gctttgcttt ctcagcattc ttcaaacaga 3026221 ggcagcattt tggaacaaac agaaggggat ttgtacaaag acctgcttca tatcggaacc 3026281 tgtctcttgg aggagctcga acatagaaaa gatatcatta aaatcagctt tcgtgaaccg 3026341 gccatgtttc aggatgtcat taaccacgtc actgaatatc cccaatctat gaaacagcta 3026401 ttggttgatt atctcaaaac gatgggtgag aaaggggtta ttcagacagg aaatgaagcg 3026461 gaacatgccg acgtgttcat gtcgattatc ttcggttatt tcattcaccg tctccactta 3026521 ggagaccggg tcatatcaat gccccaggaa aaaatgctgg agcatagcac agctctattt 3026581 gtcaaaggaa tttctgctga ttaactcctt ggcataataa aaaggaggat cccaatgagc 3026641 tcaagaaaag aatgggcgct gatcgtctcg ctattattgg gggccattct ggttcccatt 3026701 aactcaacga tgatcgcggt cgcgctctca tctatttccc atacgtataa cgagtccatc 3026761 gcaagcatca cttgggtggt taccgtttat ttaatcgtga tggcagtcac acagccgatt 3026821 gcaggaaagc tcggtgacat gtacggcaat aaaacaatgt acttatgggg agtcggcctt 3026881 tttctaatcg catctctagg ctgcgccctt tcaccgagtc tgctcctgtt aattgtcttt 3026941 cgggcattgc aggctgtcgg cggggcattg cttacgccaa acagcattgc cattatccgg 3027001 catgttgttt ctgaaaaacg cctaccgaaa gtgtttggat ttttcggact gggcgcggga 3027061 cttggtgcag cactcgggcc ttttatcggc tctatactga ttgacagctt cagctggcat 3027121 tcgatttttt gggtcaacat cccgttcctc gccattgctt tatttacggc attaacgatg 3027181 tttcctcaat ataaagaaaa taaatctgac gcgccgctgg atatcatcgg ctctctcttg 3027241 cttgcaggca gcatcgtttc cattatcctg ctgacgaaaa atgaggctcc atggggatat 3027301 actgtataca gtgtattgat acttcttttt gttccgcttt ttttcagaag agaaaaacgt 3027361 acccagcacc ccatcattga ctttgcactg tttaaaagct caacctttac aaatgcgaat 3027421 ctatcagtct tgttaagcaa tttgatgatg tatgccgtct tattgattat gccgttattt 3027481 atgacgaacc aatttgggct taatacatct aacagcggga tggcgctttc tgtattttcg 3027541 atcttcatgt cagccagcaa ctgggtgggc gcgcagctcc atcacaaatg gggagccaaa 3027601 aaaatcattt ttctttcatt tgccatgatg gctggtgcga atctattatt tttgctgtta 3027661 agcagctcgc attctgtctt gttcctcatg ctctctctta tccttggcgg gctcgcttcc 3027721 ggagtcggtc tgaccagcat gcaggtttca tcccttgcca cagtagaccc cggtatgtca 3027781 ggagtggcat ctgggatttt ctcgaccttc cgttatttcg gaagcatcat ttcatcagcc 3027841 ttaattggcc tgatttcggg atatcacacc ctatttatga ttctctttgc tgtatccatc 3027901 atcggcgttt ttgtttcatt gggcatcaaa tctgatgaaa cggcacggat agaaaaaaac 3027961 tcagcgtaac acaaaacagc ccggcatcgc atcatcctgc ggtgccgggc tgccttttat 3028021 gatcccgaag cgactgcttc gtcttcacgg tcatccttta cgaagaggat gcccaattca 3028081 tgatgttctc cttcataaga agctcgctgg tcaaaacgaa tttctccatt caaaccgata 3028141 atttcaagct ttacatatgc acggttatgc tgaagcgctt catagaaatc agaaacgttc 3028201 ttaaccggta tgccattgac tttcgttatg atttccccga ttttcaattc cagatcctca 3028261 gccggcgtat tggggataat cccaagcacc attaagccct gatccctttt cgagaaataa 3028321 aacggagccg cgttatcatt cactctttgc tttatggaca gaaaaatacg ccctaacaaa 3028381 gcggtacaga ccgctgcacc cgcaagcggc gtccacagta agctcgctgc accgagaact 3028441 gcgacggcaa gaccgagaat acaaacgcgt ttcgctgtga tccttatact cgtttcaggc 3028501 agcgatccct gtaccctttg tccaaatccg acaaagtaag gaatccatag aaaatggaat 3028561 gagccgccgg gaaccgtaaa cacgggccac cagctaaggt gcgattctaa accattaccg 3028621 ggcacgagaa ggaacagcgg caaaagccaa acccggtttg ccagctgctg tccgatcggc 3028681 aaaccgcggc tgcttacgac aagtgccggt gatgttctca catgcgcaga acgataagca 3028741 accgctcctt cagtgataat cagcaaacct agaaacacag ccacagccgg ccaaacaact 3028801 gcaaatcctt gcggaaatct ctccagaaag ggctccgcct gatatatttg cagtccaaaa 3028861 cctatcagca tactcacact gacgatatat gcagcagaca tccagtttgc gcgaagagtg 3028921 aacgctgccg ctgcagtgat aacggcaata atcgcaagta aaccgagagg aatcgatatt 3028981 ccgagtccac ctaaaataac tgacaaaaga agacctggaa tcagtccctt tgtatatgta 3029041 aatttcagat catcataaat atctgctatt cttgtatgaa aggtttttcg ttcccgtttg 3029101 attcttacat agccgaaagc caaggttatg atgataaaaa accagaaaag cgggtgtaag 3029161 aagaacaagc ccgcgctttt taacagttca attccccatt gaacagacac tatctctcac 3029221 cgcctcaagc caaacatgtt actcatattc tatcaaatat taaatggctt ggatatcctc 3029281 aggagagttt atctctcttg cgtcatccac agcgtgacat tcgatagtga aaaatccttt 3029341 aaatagtggt ttacatccac atccaataac ccgctgatta gatgcatcga cctttttata 3029401 tctgtcagat taattcctaa tcgcttatgg tttttcatta agtagttaaa ataatgtttg 3029461 gcgcattcct cattaatgtc atttactgat tcgacattgg tgtaattgac caaatatctg 3029521 ctgaacagca taagaagact tagtgctttt gtagctgaaa atgttacgtc ttgtgttctg 3029581 tcttttaatt gttccactaa ttcataatat ttttttttca cgcacaatac ttgccctctt 3029641 caattgtgaa cccccatttt ctttatacag ataagcacgg gccagtataa gcagcagtac 3029701 tggagtgcta acaagcattc tcgctaacgt tactctttaa atacctgtcg ttcagctgcc 3029761 attaacctga ttactgttct ttttagaacc ttcttatatt gtatgaagta aacaaagact 3029821 aggcaacttg caaaagtttc attttaaatg catattaact cgttagaaag tctctctcat 3029881 atattgatat cgggtaataa cagtccttta taaatgttta tttgtgaaaa tttttttaat 3029941 ttcttgtcaa aaactcattt tttatgtgac ttatgatcca taatctcttt aagcacaaag 3030001 aaacaggaga tgaaatacca tctcctttaa ttgacaaata atgatttcaa tgctgtttga 3030061 agctgcaaat catttttttc atctgatttt ttcttttcta tctgctgatt taatgtctct 3030121 gcagtgcgag tgtcgatcac accggtttta ttcagcttgt tttgatcctg aaaagccata 3030181 accgcttttt tcatgtcttt gctgaaatag ccatcctcac gtcccggatc aaagctgaga 3030241 ccttttaaca atacctgcgc atgcttgacg tcttcattgt tcatgtccac tttaagcggc 3030301 tctttcagct gtaagggccc ggcggaaaaa taatcgggct gcttaatcgc aatggtcggt 3030361 tcaattcctt tcttatgaat ccagtttcca tttggcgtca gccacttgta aagcgttaat 3030421 ttgatgttgc tgccgtcccc cattggcaca gcctgttgaa ccgttccctt tccaaaagac 3030481 gtatcgccta caacatcata atggccagct tcctttaatg cgccggcaag aatttctgat 3030541 gcagaggcac ttcctttatc cgtaatcaca ttgacagggt acgctttttt atgggtcaat 3030601 gttgaaaaat aacgtttttt atctccattg cgttcagcaa tctgaatata cggctgatcc 3030661 tttgtaacga aatgcttaag aatttcttcc acactttgaa gatatccacc cgggttgccg 3030721 cgtacatcaa tgacaagtcc ttctatttct tttttctcaa gctccctcag cgcttttgca 3030781 aaatcctctg cggtgtgctc agaaaaagta gagatggcaa tatatccgac agaatgcccc 3030841 tgtacttttt tctctgatgc aaaaaccgtt tcgagcggaa tctcagctct cttgatccgg 3030901 aatgacaact gcttcttcgt tccaggccgc tgaatcttca ttgaaacgct ggaccctttt 3030961 tttcctctta tttttaacac agcgtggttt aaatccttgc cggccatcga ttctccattg 3031021 atgctgataa tttcatcatt aggcttcaac ccggcttttt ccgctggcga tttcttgaat 3031081 ggagaaacaa taataatttt gccgtcttcc attccaacct cagccccgat gccttcaaat 3031141 gaggaatcaa gagaatcaga aaattgctta gctgtctgct tgtccatgta aacagaataa 3031201 ggatcattta gcgtagacag cattccctgg atggctccct cgagcagctt ttctctatct 3031261 actttttcta cgtactcatt cgaaattaac tcatacgctt tttcgatttt gtccatagct 3031321 ttatcccgtt cagagtcagc ttgtgccgtc gcgggaactg ctgcagtctg gggcttatcc 3031381 atctcaagca ggttgattcc cgcatataca ccggcgcctc cgaacagcat gctccctgct 3031441 gctatcacag ccattatttt ttgattcatc ctttactcct cctgtatgcc agactgtctt 3031501 taccaaaacc tagagatagt atatgtaaag gatggagatt tcatgtaatc atagaagaaa 3031561 aagaaggcaa atgaaaagcc gtcccgaaaa cggaacggct ttttcacttt atactcgcag 3031621 aaacttgcgg atggaagtca gacttcccca tactccaatt actgcgccga ttgcaatcag 3031681 cactagcgaa acttggaata caaatggatt ataaggaaga agagagacaa atgatccttg 3031741 aacctttgga acgacccatc cgatgacgta ttggtaagtg ctcagcacca gtgcaatcgg 3031801 aatcacagaa ccgaatacgc ctagcagcaa tccttcaagg aaaaacggcc agcggataaa 3031861 ccagtttgtc gcgccgacaa gcttcatgat ttcaatttct tttcttcttg cgaaaattgt 3031921 aattttaatg gtgttggaaa ttaagaacat cgccgtaaat accaggccga taattaacgc 3031981 gattccgatg ttgcgggaaa cgccgaccac tttaaacaaa cggctgacct cttcttttcc 3032041 ataagtgact ttataaacat gatccatttt ttcgatcttt ttcgccacgt tcggcgtatc 3032101 atgcggatct gtcgttttga cgacaaacgc atcattaagc gggttttcct gatccttcat 3032161 tgtcagggat tttccgctgt caccaaaact gtcaaccagc tggtcaagct ctttttcttt 3032221 agatgaaaaa gtgacactct gaatgccctt cagttcctta atatcgttct gaagcttgtc 3032281 ctgtgccttc tgatctgcag tcagatcaat cagcactttg atttcgactt gtttttctgc 3032341 attcgtggcc atgttattca aattcagcat aatcactaaa aacacgccga ctaaaatcag 3032401 cgtaacggtt acagcactaa tggatgcaaa tgtcatccat gtgtttctcc cgagagattt 3032461 aaaactctca cgcaagtggc gcccgagaat tttaatcata tgaaccatac tcccctcttg 3032521 actcatcacg cacaatgata ccatcttcga ttgcaatgac acgtttcttc atggtgttta 3032581 cgatttcttt attatgtgtc gccatcacga ctgttgtccc gcggttgtta atttcctcca 3032641 gcgtcttcat gacttcccag gacgtatccg gatcaaggtt tcctgtcggt tcatcagcaa 3032701 tgacaacatc agggttgttc acaattgatc tggcaataga tacacgctgc tgctccccgc 3032761 ctgaaagctg gtcaggaaat tgtcgcgctt tatgcttcag ctgcacgaga tcaagcactt 3032821 caagcacccg tttcttaatg acagacggct gttctccaat cacttcaagg gcaaatgcca 3032881 cattttcaaa aacagtaagt ttcggaagaa gcttgaaatc ctgaaagaca acacctattt 3032941 tgcggcgcac gaaaggaatc tctttttctt taattgtcgc gagatcttta tgattgatta 3033001 aaatttgtcc ttttgtcggt ttttcttctc tgtaaatcat tttaataaaa gtagatttac 3033061 ctgctccgct cggaccaaca acatacacaa actcgccggg atgaatggta acagaaatcc 3033121 cattgagtgc ttttacgccg ttcggatagg ctttatatac ttccttcatc tctatcatga 3033181 aatcacctaa tcttttatat cattttatct atcacacggt catactcttc gaatgcattc 3033241 gacaatttat gacccattca tttgtaaaaa gatgaaaaat ctgaaagttc cctttttcaa 3033301 tacacttcat tatacgtcaa atttagacat aatactatta cagtttcttt tcattcatat 3033361 tgtcaaggca taaaaacatc cttgccagca ctcggcaagg atgtttttat cttacttttt 3033421 ttctgacagc catttggcaa taacagcggc ttcgttatca tctacaagcc cctttggcat 3033481 attgccgcgg ccgtttttaa taatgctttc aattttgtgt tcatcgtatt tgcctccgac 3033541 ctcttggaga ttaggccctg acacaccttc taaatccttg ccgtggcagc ctacgcagct 3033601 ttgctgatat aattcttccc cttcagatgc agtggcttcc gtcttgctgc cagtgtctgt 3033661 cttctcttct tttgcatcgt ttgatccgca ggcagccaac agaacagaaa gcgcaaatcc 3033721 aatcattagt atcgataact ttgatttcat gttgagaagc acaactcctt tacgatctct 3033781 tccatattat aacctcgttt aagcgcgttt gaaaccctcg cccagcacct cgctcgcgtc 3033841 tgctacaatt acaaaagctg actcatcaat ctgtttgacg atttgtttca atttggtgaa 3033901 ttcagtttgc ccaaccacgc acattaaaat cggacggtca tcgtcagtat atccgccgac 3033961 tgcagaaatt tttgtcacgc ctctgtcaat cttctgtaag acagcctcct tgacagcctg 3034021 ctcctgcttt gtaatgatga gcgccatttt tgaacgatta aagccgactt gcacaacatc 3034081 aatggttttg ctggacacat agacgccaag catggcatat aagccttgct caatattaaa 3034141 tacaatcata gccgtaacaa cgatcattcc gtcaatgatg gcgagacact tccccaatga 3034201 cagaccggag tacttatgaa tgatctgtgc agccaaggct gtacctcccg tcgaaccttt 3034261 ccctaagtac acaataccaa ttccgatacc tatcccgaca ccgccaaaaa tcgccgccag 3034321 gagttcatga tgagtggcgg gctgaatatc ccttgtcaga aacactacta gcggcaaaaa 3034381 cacagaacct gcaagcgtct ttagtccaaa tttcccgccg agcaaaatga cgccagcaat 3034441 aaataaaggg atattaataa tccactgtac atacgctgct tcaaaaccat atgattgtaa 3034501 aatcgtactg atcccgctga ccccgccggc ggcaatctta ttcggaagca aaaatacatt 3034561 aaaggacacg gccgtaatcg ctgctcctat caatatgtat acataatccc gcaaaatcca 3034621 caatgtttta ttccgtacgt ccatcatata tcctccgttt cttccaatgc tctccgatag 3034681 cattttaatc cttccctgat tagatgtaaa taacacccaa atacagtggt aatatgctaa 3034741 agcagcagtg aaatcaagga tataagaaat aaaaaaacac acccgtatgc atcaggtgtg 3034801 tttttcagct tatgaaagct tagaacgcag gtaggcatca ataaacgtat caatgtcacc 3034861 atccattaca gcttgaacgt tccccatttc tgtattggtc cgatggtctt ttaccatgga 3034921 atacggatgg aatacataag aacggatttg gctgccccag ccgatttctt tttgttcacc 3034981 gcgaatttca tccagctctg cctgctgctc ttcaattctg cgctgataca gcttggcctt 3035041 cagcattttc atggctcttt cacggttttt aatttgtgag cgctccgttt ggcatgtcac 3035101 aactacgttc gtcggcaagt gagtaatccg aacggctgaa tccgtcgtat tgacgtgctg 3035161 tccgcccgcg ccgcttgcac ggtacgtgtc aactttaata tcctccgtac gaatatcaat 3035221 atcaatttca tcgttaaatt caggcatgac ttcacatgaa acgaaagatg tgtggcggcg 3035281 gcctgatgaa tcaaatggtg agatccgcac aagacgatga acaccttttt ctgctttgag 3035341 atacccgtaa gcgttgtgtc ctttgatgag caatgtcact gacttgattc ccgcctcgtc 3035401 acctggaagg taatcgagag tctctacttt aaagccgcgg cgctctcccc atcttgtata 3035461 cattctaaga agcatagagc cccagtcctg tgactctgta ccgccagcac cagggtgcag 3035521 ttctaaaatc gcgttatttt tatcatacgg ctcgctgaga agaagctgaa gctcaaactc 3035581 attgaactct tttgttaatg actttagttc tttttcaagc tcaagctgga gatcagtgtc 3035641 cggctcttct ttcaaaagat catgagtcat ttgtaattct tcgtgggatt cattcaattt 3035701 tttatacgaa ttgacataat cctttaaacc gtttgcttca tttataaccg tttgagcttt 3035761 ttgctgatca ttccagaatt ccggatcagc catttgttca tctagctcag caatgcgggc 3035821 ctcctttgat tcgaggtcaa agagaccccc taaagtccgc taaacgagaa gccatatttt 3035881 cgagctctgc tctaatttct gataattcca tttcattcac ctcattaaaa gatccgcagg 3035941 cgcctgcagg cgccgcggtc agtaaacttg ccggggcgaa ctattcagta cggccgcagc 3036001 aatttttata ttttttcccg cttccgcagt ggcatggggc atttcgtccg atatcaacca 3036061 ctttgcgaac cggtgctttc tttgcttttt tgttatcgtc gccttcttgc ggctgatgag 3036121 ctgttgtttg accttgtaca acctcttcac gctccagatt gttttcaatc tcagctttca 3036181 tcacaaattt tgcgacttcg tcctcaattg attcaatcat atgctcaaac atcgcaaaac 3036241 cttccatttg atactcacga agcgggttcg tctgcgcgta agcacgaagg tgaatccctt 3036301 ggcggagctg atccatcgca tcaatatgat ccatccattt agaatcaacg gcacgaagaa 3036361 cgataacttt ttcgaattcg cgcatttgct ctttgccgaa ttgctcttcc ttctcattat 3036421 attttgtgat gatgcgatcc ataatgagct caagcatttc atccggttct ttgccgaaga 3036481 tatcgctctt ctcaagtgca ccttcatcaa gataagttgt gttgataaga tcaactagac 3036541 cgtcaagctt ccactcctca ggaagctctt ctcttggcgt ataggctgca attgcgcgtt 3036601 cgagagaaga cttgatcata ttttcaacga tttcacgcag gttttcagag tcaatgactt 3036661 caaagcgctg cttataaatg acctcacgct gctggcggag aacatcatca tattgcagaa 3036721 gctgtttacg cgaatcgaag ttattgcctt cgacgcgttt ttgagacgat tcaaccgcgc 3036781 gagataccat tttgctttgg attggagtag agtcgtccat gccgaagcgg tcaagcatcg 3036841 ccattgtccg ctcagctccg aatctgcgca tcaattcatc ttccatagaa agataaaatt 3036901 gagtaatccc cgggtctccc tgacgtccgg aacgacctcg aagctgattg tcaatccggc 3036961 gtgattcatg tcgttctgtt ccgactacag cgagcccgcc aagctctttt acaccttcgc 3037021 caagcttaat gtccgttccg cgccccgcca tgttagtcgc aatcgtaact gcgccttttt 3037081 ggccggcctc ttcaatgatc tgcgcttcac gttcatggtt tttggcattt aacacttgat 3037141 gcggaattcc tttgttttta agcagcttag aaatcaattc agatgtttca acggcaaccg 3037201 taccgactag aacaggctgt cccgtcatgt aacgctgtgc gacatcctcc gcaactgcct 3037261 taaactttcc ttccatcgtg cggtaaatta aatccgggcg gtcatcacgg acaacaggcc 3037321 tgttggtagg gatcgtgaca acctgcatgt tgtagatgtt gcggaattct tcttcctctg 3037381 tcttagctgt acccgtcata ccggcaagtt tttcgtacat tcggaagtag ttttggaacg 3037441 taatcgtcgc caaggtcatg ctttcgtttt gaatctcaag cccttccttt gcttcaatcg 3037501 cttggtgaag cccctcactg tagcggcggc ctttcatcag acgtcccgtg aaggaatcaa 3037561 caataacaac ctgtccgtct tccactacat agtcaacgtc cttttgcatc gcaacgtgag 3037621 cttttaaggc ctggttgata tggtggttga gcgcgacatg cttcacatca aagaggttat 3037681 cgatgccgaa tgctttttcc gccttcgtca ttccttcttc agtaagctgt acagcttttg 3037741 ttttgatatc gtacgtgtaa tccttctccg cttttaacgt gcggacaaaa gcatttgcct 3037801 gtacgtacag cttagtggat tttgcagctt gtccagaaat gataagcggt gttcttgctt 3037861 catcaattaa aatagagtca acttcatcta ttaccgcaaa atgaagcggg cgctgaacca 3037921 tctgctcttt ataaagaacc atattgtcac gcaaatagtc gaagccaagc tcgttgtttg 3037981 tggagtaagt aatatcagcg gcataagctt cccgtttttc gtcttttgac attgagttta 3038041 aattcaaacc gacagtcaaa ccgagaaact cgaaaatttt ccccatttgc tcagcgtcac 3038101 ggcttgccaa gtattcgttg acagtcacga cgtgtacgcc tttaccggtt aacgcattta 3038161 aataaacagg cagggtagac gttaatgttt tcccttcccc tgttttcatt tccgctatat 3038221 ttccgtcatg aagcgccacg ccccccatga gctggacttt aaacggaaac atgcctgtta 3038281 cgcggcgtga agcttctcga acaacagcga aagcttcaac aagaagatca tccgttgtcg 3038341 cccctttttc aagacgctct ttaaattcaa ttgttttatg tttcaatgcg tcgtcagaga 3038401 gattttcata gtctccgcga atcgcatcaa tatcgttagc aattttttcg tatctattca 3038461 gcgtacgttt tgttggatca aacattttat ttaaaattcc aagcatttat aacgctcctc 3038521 tatcatcaca cgcctatttt agaggcatgt ataaataatt tactagtcca tgtatacctc 3038581 tcattatcat atcatacctt ttgttatttc caaagaattt gcaaataaga aaaacaaaaa 3038641 ccttccgcgg acatcacgga aggcttctct tcattattca gtcggttcaa ttaagccata 3038701 tttcccgtca tttctgcggt acacgacatt tgtaaggttt gtttccgcat ttgtgaaaac 3038761 aaagaaatta tggccgagca tattcatttg caagatcgct tcttcactat ccatcggctt 3038821 taaattaaag cgtttctgac ggacgatgtc caagctctcc tcctcttcta tgtcatcctg 3038881 aaccgcaata tctgtatcag agccaagacc gtttgccaat aaatattttg gagagccctg 3038941 ctcacggaat ttacggttta ctttcgtttt atgcttacgg atttgacgtt ccagtttgtt 3039001 tgttgcgaga tcaattgcgt tgtacatatc ctcgttatgc acctcggacc gaagcgccag 3039061 atctgtcatc ggaatcgtaa cctcaacctt agactccttg tcattgtaaa acttcaagtt 3039121 gacgttcaca tcagcatcca cgctatggtc aaaatagcgc tccagcttgc cgatcttcct 3039181 ctcgacatga tcctttaacg cgggtgtcac ttcaatattt tctcctctga tgttatagtt 3039241 catcaaagaa cgcctccctt ttattaagga tatgtatcta tttctctttt accctttaca 3039301 attcctgctg aaacataaat cttttgtgaa aattcagtga actttgtcga attttgtttg 3039361 tatttgctct gttattggcg gctgctaagc ttttgaatca aacagtttca ttttgctact 3039421 tttcggcagc tcagctttaa ttgatttgct gtaattgaag ttattttcct taggaaccag 3039481 catatcgtac gaaatagaga tgaattgcag cgcgtctctt gtcagctgcc tattcatctc 3039541 atttactttt ttcagacgtc cgagaacttg agaaagagat tcgtatagtt gttccagctc 3039601 ttccttttca ctgcctgagg ttttggcgat acatgcggaa atagtattat tttcgctata 3039661 tccgagaaag gccgaagttg ttttgatccg gtcatcttct gtctgcgtga ttgcttgaat 3039721 atatttttgc tcttttgtca aaatgttaga aagctctttt gttttgccgg ctttgagcgc 3039781 ttccgtcttt tcttcagaca gcgtgagcag gtgctcatgc agaacgcaaa gtcgcttcaa 3039841 ttgttcaata attgccttcg ctgacatggg ctttctcctt ttttattgct ttttataaaa 3039901 attaatcata tttttcgcaa tatgatttgc gtctactttg tatgacccgt tttcaatttg 3039961 cgctttaagc tgcgcaattt tttcctgtcg tgaaccagtg actgcgtcgg atgcatgttg 3040021 catttcttta gcctgtgatg aaatttcaat tttatcttga ggttgtgcaa cagttttttg 3040081 caccgcttgc ttatcataat ttttttgata tggattaacg gattgtgttc caaattgatt 3040141 gattttcata ggattcctct cgctttccgt tgcagtcttt aaacaatctt aaccctttta 3040201 tcgactgcgt tttcagttag tttagggaat cagctgtttt tggtattata ggcatagtat 3040261 gtgtcttttt tactattttc tttctcgatt ttcagagcat cctcgtggtt caaatgatcc 3040321 atttgatcct taatatcaga ctggcaagcc ttgcagaact tgccttctct aatcgatgtc 3040381 ccgcaccttt cacaagggta tgccaaatta ggaagatgag tgatctgaat tcgcttctgc 3040441 ctgatgaatt tcaatatcag ctcttcttcc acacctgttt cctcagttat ccggctcaaa 3040501 gttgattgcc ggttttcctg ttttcttaaa aatttataga cagtctcaaa tgatttttct 3040561 tcttccttaa tacacgcctg acatacggtt tgcagctttg tttttaaaaa taaagcattg 3040621 catttcggac aattagccag ttctcccatc tttttttctc cttattagat aatatgcctg 3040681 tgtcaatttc tagtgattat atcggcataa aaacagaatc atttagcttc tgatcaaggt 3040741 aaaagatgac actgaagcgg cttttccttt ttctaataag cagcgggctg cgaagtgcaa 3040801 ggtggcgcct gttgtataaa gatcgtctat taaaatgata ttcatacctt ctgctgaatt 3040861 attttttgta tcaaaaatgc actctgacag caggcgttct gttttctttt tctttgactg 3040921 tttctcatta ttcaggcgaa tgaggggatg gtgggaaggc cggtctaaac attctgccaa 3040981 gagatgtgcc tggttaaatc cgcgctcttc ttcccgttcc ttgctcagcg gaataggtac 3041041 aagaacaaaa tgcttatcgg ggtaaacctt agaaaaggtt gaagaaaaat cacttttaaa 3041101 tgcatttatg atttctgcat ctcctctaaa tttaaaacgg gagagcgttt ctttcatcat 3041161 atcattatat gtgtaaactg aacggttttg acgcaatagc aaactgtctc tgatccttgt 3041221 tctccacacc tcgcaatccc tgcatacggc atgaacagat tgaggtctgc cgcacagggg 3041281 gcagatatgt cctgtgattt tctttaattt gcttctgcaa gaataacaaa ccttttcatc 3041341 aggctttagt aaaaaaaggg ctctccatgt aacatcttga gaaaattgcg aatcacataa 3041401 taaacagatc agtttatgaa tgcctcctcc tgcttcgttt gacataaatc gcttggactc 3041461 tctgaaacta ctgcagcaga ttcagccaaa atgacaagca ttgctgtgtt tttttgttta 3041521 tctaccagct cagctttcgt atatgcgatc tttttaaaat cagtaacgta ggatggactc 3041581 actttgttta aagaaagtgc caatacatcg ttttggcata cttggcaagt acaggccata 3041641 tgaagctggt ccatatatcg gtcgagcagt tctttcatta cgatttcttt tgaattgaca 3041701 agcattttta cagctcctca tcatcggtta tatgagtata ctgtaccacg ttttcaaata 3041761 atggctagtc tgtacattca acttttgctg ccaattcatt catttctttt atatgctttc 3041821 ttgcatcgag catactcttt gttttgccga agtgaaagta aatgacatcg ccgtccgcat 3041881 attctttatg ccggccggtt cttcctgcaa tttgaacaag tgcgctttcc gtaaagatag 3041941 acgattccgc tcctagtaca cccgtttgca ccttggggac tgtgacgcct ctttccagta 3042001 ttgttgttgt gattaataga tcgagctgac catctctgaa ttgctgcact ttctcctttc 3042061 tatgcttgtc ttccgcgtgc acagatgcgg ttcggcaatg aacaccttta aagcacgcag 3042121 cagccttttc cagaatagaa acggaaggaa cgaataaaaa aacaggcctc ccttctttta 3042181 catgaaactc tatccatctt ttcaccgctg gcggaatttt atttcggttt aatttcttct 3042241 tccagtttcc acaccataca aagcgcggtt cgggtaaagg tttccggtgg tgtcttgcgg 3042301 ggatgcgaac tgaatgtaac tgtccgttca gtgcttttct ttttaattct ttaggaggtg 3042361 ttgcacttaa ataaacgagg gtgctgtttt tctttcttgc tttttgaaca gcgaattgaa 3042421 gggtttgatc agcagaatat ggaaaagcgt caacttcatc aatgatcata acatcgattg 3042481 catctttata tcgcaaaagc tgatgcgtag tggaaatcat aagcggagat agccgccctt 3042541 tgtcatcgct tcctccgtaa agcgctgaaa tgtcagcacc ctgaaaggca gccttgagtc 3042601 ttggagcaag ctctaataca acatcggtgc gaggtgttgc aatacataca cgcagtcctt 3042661 gatttaacgc tgattctata ccaggaaaca gcatttctgt tttgccagcg ccgcaaaccg 3042721 cccagatgag gagctcttct ttttttgata ttgcttcaat taaaacattg gcggcttttt 3042781 gctgtccgct tgaaagcttg ccatcccatg tcagcttaat agacttccag tttgattcat 3042841 tttcctcttt ccatgaatat aaaggaacct cctcactcac tctgcccatc atgacacagg 3042901 aacggcaata cagcttattc tttccagatg agtgataaaa agaaaaatac cgctgatcag 3042961 tttgtccgca cctattacat ctatatctcc gtttatttat ggatatagaa ttttcagcag 3043021 tgatatatcc attcttgata tgccattcaa tcatctcatc ggaaaatgag agctcagtcc 3043081 tgagcaaatg acggcttcga agcgtctgct gcaattcttt tgaaaaggaa ctgttttttt 3043141 caactggcac attcacatag cacgcctcct ttcgaaacag tatgcctgaa tgaatatttt 3043201 ctgtccaact attaaaataa gaatataaaa aaatctccgc tctaaaaacg gagatttggc 3043261 cttatttaaa acaccagcaa attcctaacg caccttcacc caaatgagtg ccgattaccg 3043321 cgccaaaata gctgttataa aattcaacat gaggatattt tgcagaaagc tcttcaatga 3043381 ttttcgctgc ttcttcctct cgattagcgt ggataacagc agctcgcata ggcaaccctt 3043441 tactcgcatc ttcgtctaaa agctcataaa ttcgcgaaat tgctttttta cgtgtgcgaa 3043501 tcttctcaaa aggcacaatt accttattgt caaaatgaag gataggcttt acctttagaa 3043561 gactaccaat gaaggcttgg gcgctgctta atcgcccgcc gcgctgaaga tgggctaagt 3043621 catctaccat aaaataagct cgaactgttt ttttcatttc ttccagttct tttataatat 3043681 cttccggcga tgatgctccg tttttgatta attcagcagc tttaagggca taaaagcctt 3043741 gagccaagca gctgatctct gagtcaaatg gatacacatc aatattgtcg accatcgaat 3043801 cagccgctgc tgcactgctg aatgttccgc tgatcccgct ggaaagatgg atactgataa 3043861 ccgcatcata agacttgcca agctcttcat acaacgcaac cagctcgccg attggcggct 3043921 gagaagtcgt cgggagctca ttatgttttt tcacttcttc ataaaagctt ttccagtcca 3043981 actcaatttc ttcacggtaa gtctcctccc taaaaacaac ctggagaggg atcatatgta 3044041 tctgatgttg ttcacgcatt tctttcggaa tatatgccgt gctgtctgtt acgactgcaa 3044101 tattcatagc ttcgatacct gccttattgc tttataactc tattgtaagg gaaacggcag 3044161 cctaaaaaaa gacctgccta gtaaaaggca agtctcctat tatactatct catttctacc 3044221 cagccatttt taatggcgac cacaacggct tgcgtccggt cgtttacatt cattttttgt 3044281 aaaatattgc tgacatggtt tttaacggtt ttctcactga taaacaatga ttcaccaata 3044341 ccgcggttgc tttttccgtc tgcaagcatc tgcagcactt cacattcccg cctagttaaa 3044401 atatgtaatg gtctgcggat ttcagggtaa acctcatgtt gagggtgtgc agaaactccg 3044461 cttgttgcaa ggcggcggaa ttcgttaacg aggttgtgag taaccttcgg atggaggtaa 3044521 gatccgccct cagccactac tttaaccgct tcaattaatg tatcagcatc catctctttc 3044581 agcagataac ctcttgcacc tgttttcagg gcatgtgtta cataattttc gtcatcgtga 3044641 attgatagaa taattacttt agattcagga tacagctcta caagctgttt tgtagcttcc 3044701 acaccattta cgtttggcat attgatatcc atgatcacaa catcaggatg atagtgctca 3044761 acaatacgag ccgcttcgtc cccgtcatca ccttcggcta ccacttcaaa ggtaggttca 3044821 aaatccaata tccgtttaac accttcacga aataactgat ggtcgtcgat aataacaatg 3044881 tttactttag tcacaagcca cgcctccttg tattattgtt ctatatactc tagcattcgg 3044941 tcaatatgcc ttttggctct attttacaaa tcatagtcaa agagataacg gaaccttaat 3045001 cataataaat gtcccaagac ctattttcga atctattgtc atcgttcctt ccaataaatc 3045061 tactctttct ttcatgccca gcaagccgaa tgatttgttt ttcttctctt tcgcttcctt 3045121 caggtcgaac cctttaccgt tatcttttat cattaaaatc acaaaatcct ttgtgatctc 3045181 aactttgact gtaatttctt cagattcaga atgctttagc gcattagaca cagcttcctg 3045241 tgcgagcctg aagagcgcaa cctcaaactg aggcgctagc ctctgatcct ctgtttctcc 3045301 aatgcactga aaatgtattt tgaccttccc gttatattcc tcggttgtat atagatattt 3045361 tcttaaagtt ggaatcaggc ctaggtcatc aagggccatc ggtcttaaat catatataat 3045421 ccttctcact tcgtaaaggg cattccgaac attttggcgg agatttttaa tttcttggaa 3045481 tccgtcctct gcgccccggt cacggaaaat ccgctcgatt aattccgatc tcatcataac 3045541 attcgccagc atttgagcgg gtccgtcatg gatttctctt gagactcttt ttcgctcttc 3045601 ttcctgcgcc tcaataattc ttaagccgaa atcctgtttt gcctgagcat cagcaagaag 3045661 cagtccaact tcgcgcaaat cctgattcaa gtagttgagc acaactgtaa tttggcttac 3045721 taatgattct gaccgctcaa tgatttcctg aagccctagc aatctgcgct ccaaatcgtc 3045781 ccgccgttcg cgcaattgct tctcacgctg ctggatcatc gtcaattcta cctgcagctt 3045841 atgggctttt tcataagcat tgcggatttc ctcttcactg aatctatgaa aattacggct 3045901 gacctcggat aaacggtttc tcgcatggcg agtttgcact tcaagtttat cgccaagctc 3045961 aatcacttca tacacctgct gtttaatttg tttcagttct tcgaccagct gttcatactg 3046021 ctggcgtgac tgctccccga tttgaaaaac ctcgtccttg ctcccgtcaa cggttttcag 3046081 catcttcatc aaaatagaat ccagcacttt ggaatccatc tttgttttat tcataatttc 3046141 cctccgtcac ggcgttgtca tatattttta ttataaatgt aattgatctg caaattatgt 3046201 cgaattataa tgaaagaatg cgtatattct agaaaaaaac atttttatat actatctact 3046261 ctttatgata ccaaaatacg cacaaaaatt ctaaagactg tacgaatttg tataggcagt 3046321 cttttatgct tagcaggagg gtcagctagc atgctgcaca gctattttac tgtgaaagaa 3046381 gcgggagaac acgagattgt tatagaaaaa tcgcgtttta tctgtcattt aagccgtgtt 3046441 tctaccgaac aagaggcaca ggaatttata cagaaaataa agaaacagca ctggaatgcg 3046501 actcataatt gctcggctta tgttattggc gagaatgatc atatccaaaa agccaatgat 3046561 gacggggaac caagcggtac agcgggagtg ccgatgctcg aggttttaaa aaaacgcagg 3046621 ctgaaggata cttgcgccgt cgttacacgc tacttcggag gcattaagct tggtgctggc 3046681 ggattaattc gcgcttatgg gaaatcagtg tctgaaggat taaatcatat aggtgttgta 3046741 gaacggaagc ttatgcgaat catgcatact tctgcagatt acacatggct tggcaagatt 3046801 gaaaatgaat taagggagtc acaatttctg ttaaaggaaa tccattattc agaaaatgtt 3046861 gaattcgaaa catacgtgga agaaaaagaa accaacgctt tttctgaatg gatgacagaa 3046921 ctgacaaatg gaaagagtga tattaaagag ggagagttga cgtatcttga aaaagccgtc 3046981 aatcacataa aggagactga ataatggctg aacgcgttag agtgcgtgtg cgaaaaaaga 3047041 aaaagagcaa acgtaggaaa attttaaaaa gaataatgtt attgttcgcc cttgcactat 3047101 tggtagttgt agggcttggc gggtataaac tttataaaac cattaacgct gcggatgaat 3047161 cgtacgatgc cctatcccgc gggaataaat caaatcttcg caacgaagtt gtagacatga 3047221 agaaaaaacc attttctatt ttatttatgg gaatagagga ttacgcgact aaaggacaaa 3047281 aagggagatc agactctctt attgttgtta ccctggatcc caaaaataaa accatgaaaa 3047341 tgctgagcat tccgcgtgac acacgtgtgc aattagctgg tgacacaacg ggaagcaaga 3047401 cgaagatcaa tgccgcttac agcaaaggcg gtaaagatga aacagttgaa actgttgaaa 3047461 acttcttgca aatcccgatc gataaatatg tcacagttga ttttgacgga tttaaagatg 3047521 tgattaatga agtcggcggt attgatgttg acgtgccttt cgatttcgat gaaaaaagtg 3047581 atgtagacga aagcaaacgg atttacttca aaaaaggcga gatgcatttg aacggcgaag 3047641 aagccttagc atatgcccgg atgagaaaac aggataaacg cggagacttt ggccgtaatg 3047701 acagacaaaa acaaatctta aacgcgctga ttgaccgcat gtcaagtgca agcaacattg 3047761 ctaaaattga taaaatcgca gaaaaagcca gcgaaaacgt tgaaaccaat attcgcatta 3047821 ctgaaggttt agcgcttcag cagatttaca gcggctttac cagcaaaaaa atcgacacat 3047881 tgagcattac aggttctgat ttgtatttag ggcctaacaa cacatattac tttgaacctg 3047941 atgctacaaa tctcgagaaa gtcagaaaaa cgcttcaaga gcatttagat tatactcctg 3048001 atacaagcac tggcacttcc ggtaccgaag acgggactga cagctcaagc agttctggca 3048061 gcactggcag cactggcaca acaactgacg ggacgacgaa cggaagcagc tattcgaatg 3048121 acagcagcac aagctcaaac aacagtacaa cgaattcaac aactgattca tcctattaaa 3048181 aaatgcccgg tccttttaga ggatcgggca tttttgcgca gaaaaaaact ccggcacata 3048241 agccggagtt tttaattcct tttcaccagc cgtttataaa actttgtaaa cggcttaaat 3048301 ttttcattca cgagtcctgt cacttctgct atgatttgca taaaaataat caaaatgaag 3048361 ataataaaca aagaaagcca aattgtggca cttttaagta caatcgcact gatactgaaa 3048421 ataaatccaa ttaaataaat aactaagacc gacatccgat gtgaaaggcc aaaggccatc 3048481 agtctatggt gaatatgcga cttatcaggc gctgaaatcg gctgtttgtt taatattctt 3048541 ctgatgatag caaatgttgt atcaaaaatc ggtacgccta atataataat cgggataacg 3048601 atactgaaca atgtgacact tttatacagg cctaataatg aaagaatcga gatactatac 3048661 cctaaaaaca gtgatcccgt atctcccata aagatttttg ccggatggaa gttgtaaaac 3048721 aaaaacccca gcgtgctggc aataacgact aatgagagtg acagaatgag cacttttccg 3048781 ccggatagcg ccatgacagc aatcgttgac aggccgataa cagaaagacc ggcagcaagg 3048841 ccatccaatc catcaatcag gttaattgcg ttcgtgatgc cgacaatcca taataccgtc 3048901 agcggataag ccatccatcc taactcaaat cgttctgtta aaaaaggtac tgagaaaaag 3048961 tccattttta agccagtgct tacaatcata atggctacac ctaattgaat caaaaactta 3049021 acttttgcac ttaattgata tttatcgtca agaataccta acacaataat gatgaatgct 3049081 ccgactgtaa ttgccgtcat ccttgtttct gtgtaaatac cggatgcaag cacgcctgca 3049141 accaccccga taaatatggc cagcccgccc atgcggggca tgattttgtc atgtactttt 3049201 cgattgctgg gctggtcaac tgcacctatt ttaatcgcaa tcctttttac gattggggtt 3049261 atgattaaaa ctgtcagcag cgagacaata aacgcaacaa caatgcgaat catgcgttcg 3049321 tcaagcataa agaagtctcc tttggaatta aatgaagtct ttatttatat agagaaccgt 3049381 tccttccatt ataccttctc cttagttatt ataacaagct tcatcaaaaa gaaacacgta 3049441 taatcaaaaa acgcgcatcc caatttatag gactacgcat gtttttgaat ccctgtatat 3049501 ttcataattt gtctaaataa gcaattccaa tcttgtgtcc gggcgatgtt tcggcgcatt 3049561 tctttatagg tctcgtctcc gttttgaccg agaacttttt cacaagcggc tataaaatca 3049621 atcggatgat cgccctctac atattcgtat acatacggct tttgcatttt tgaggttgac 3049681 ggaagattag tgcctacaac aggttttcct gccgctaaaa attcaaatag tttcagcgga 3049741 aacacagctt gattatacgg tgattgttta tatggcataa tgccaatgtc gataagctcc 3049801 atataatgag gcacttcttt tggatctgcc ggaccggtcc atatgacatt gggaagcctc 3049861 agcagctctt gaaacgaaac atcaccattg gtggcatccg ggccaaccca taaaaatgtc 3049921 caatcaggct tttgcagtgc cgcttcttta atcattttaa aatcgagctt cggtttaatc 3049981 ccgccaataa aacctaacac tattccttct ctcccctgca gtatactgcg atcgggagct 3050041 tgtttatttg cagaaaacag ctcatactcc acaccgtttt ccacagtatg aaccttttct 3050101 cgtcctgcag tcagtttttt gtctacttcc ttgtgaagat aatctgatga acaggttatt 3050161 gaatctgctc gttgtataat tctcagctct gccgatttaa tgacttttcg ccggaattca 3050221 gacagcagat ttgatcggcc gctgatcggc gcagcccata ggtcactgca gtcataaatg 3050281 acctgatccc aagaatacag cgaagacagc agcgggaatc cgggaaacgt gtaccataaa 3050341 cagcagcgtt caccgtttgc agaagcaggt gtaagctcat cgagtaatgg ggagagctta 3050401 tgtctgtaaa agacatctgt atatcgtccg aaacgaaaca tttttttctg cagcaggtct 3050461 ttgacagcga attgcctgat gccagaatgg acttcctgaa actctttccc ttgggcacgc 3050521 ggagccggac atacccaaat aacttccttc gtttcctcct gagcagctaa aaattctgcc 3050581 agccggtgcc ttctgtatct caattggtct tttccccatt cagcagtggc aacgatgaca 3050641 tgaatgattg cttcttttgt ttccaccttc atcacctttt ctctctgttt gcagctataa 3050701 tctttttttc accgcgtttt ttgcatattg aacaaaacac catgttgctt tcataaaatg 3050761 aagccgttcg atctccctgt agacaaacca cgtttttttc gcagccttcc atttgttgct 3050821 ggaaattgaa ttattgacaa gccgatattc agccaggcat tcattcattc cataggcagt 3050881 aaatcctttt tttaaaagag acagccatgt ggctaagtcc tgtctcgttc tgatattcgg 3050941 catttggatc tgtcccgttt gctccctgtc aatcatcacc gtcaagcagc cgataattgt 3051001 atttttcagg gcgtcatcgt acgtcaggct ttccggcgca tgaataaatt tatcgagcgg 3051061 ggtcccgtcc tgcgccatta agctgtagcc cgtgaaagag aacgcacagg agcgctccat 3051121 cataaactca agctgctttt ccagtttgtc ttttttccat ttgtcatcac tgtccaaaaa 3051181 tgctacgtag cgcccttgag cgcgttccaa cgctttgttg cgagcaaccg cagctccgga 3051241 gttctcttcc agatacacca catgaattct ttcgtctatt ttttcatact gctgtaaaat 3051301 gtcgcgggtc ccatccgttg agcaatcatc cacgataatc atttcccaat gaggatggct 3051361 ctgatctaat accgaatgaa ccgtgtcttc aatatagtca cgcgcattat aggaaggtgt 3051421 aatgacagat acgagaggtt tccaattggt catgatcaca tctccatcgt atgattttaa 3051481 aaggattctc tgaaaaattc aggaatgaca acgaacataa aggcaatcgt aaggccaatc 3051541 ataacgccga gaactgcttt ctttttcgga gacataccgc cgcctgctgt ctcacttacg 3051601 gtttcggaat cagtaacact tgccgctttc aggttaagct gtgtgttttt gagttcatat 3051661 aaaaatctct ctttatccac tttggaatcc tcgctcaccg actcgccttc aagcgcgtct 3051721 atgctgctgc ggatgacggc ttctctttct gcatacagct tttgatcgtt tttgaggaag 3051781 gtggaggata tggcgtttaa gacagattcc gttctatcct tatcctcgtc actatagctt 3051841 aaagtcagta acgatttgga ttccgtattg attgtaagct tctctttgat ctctgctaca 3051901 tcttcatcct tttcatcagg aagcgcctcc ttcaaaaagg agtcgctctt taatagaagc 3051961 ggaatctctt ctgtgctgtt ataaaccgga tgatcatagc tccccacagc caaagtatct 3052021 tcagctgtat agctcttttg atcagcgatc tgtgacggca ggatataccc cgccgcacct 3052081 aatataattg gcaccgctat gatccaaatg atattttttt ttatgcgacg ggctattctt 3052141 atcaatatat cgttcatata agtctccctg ctttttgtag tctgtttatc tgtacatcgg 3052201 ctcaggcatt tgtctggatc gccttaacac attcacggcg gcgatgacga gcgccataaa 3052261 cacccaatgg aaaaataaat ttgaaacaga gcttgggctg atacttgata ccaggaaact 3052321 gaccatagcg gtaataagtc cttctgtgat cagttttgac tgattttcta attttctttc 3052381 ataaaacttg taaagcaccc atatgaggta ggcataaacg gacaaatatc ccagcatgat 3052441 gaacaaacca aaattagcaa gaatttcaac aagccagtta tgcacctctg ccacattgtc 3052501 agtatcatat acagcataat gctcaagata ataggataca tttcctgccc cgactccgaa 3052561 tccgtatgaa tcaaggaaaa aatgccaagc gtttttcagc agatttgccc gagccacatt 3052621 tgatggaagc ctgtcatgaa atgaatgcag cgtctgcggg gccagaaaca gctcccaaaa 3052681 ctttgaatag attttgctgg cgaaaagaac tgcgaaaaga gcaattcccg ccgccgacag 3052741 ccatatagcc attctcttta aaacaggcgg caatacaatg aagatgtaga cagcaatacc 3052801 tgcaaaaatg cccagaaggc tggctcttga accagtggca aaaattaaat acaacgcaca 3052861 gagcgagagc acaaggccaa ttgccttgat gtatccattc ttaatgtttt tcatcatcgt 3052921 gatgtaaaaa aagaagctga tggataaaaa ggtcgcaaag tcattttgat taaaaaagac 3052981 cgatgtcgga taatgctgct tgtactccgg tccgctgtac aatgtggaac tcgcaagatg 3053041 atggtgggtg atatgattgt aaaaaccaat gatcatcaga aataccgtca tcaccagcca 3053101 aatggcataa acaatcatca gccgctccat tttttgcacg tacatgacaa taagataaat 3053161 gaagaagatc cccattgcca ataaggctaa atacttgagg ccaactgtta ccgacttggc 3053221 ccacagcaga gaaacaaggc catatataaa ccaaaaggcg aaaaagagta aaatcccttt 3053281 tacttgcagc ccatgccatc tttcaatatg ggttcgattc cgaaccatgc cgaaaatatg 3053341 aaggcaaccc gctgcaatga gcagaagccg gtaaaggaac aaactgaaaa atccaagatg 3053401 aatggcaaaa aatgcattat ttaaaaaagt gcaggcgatc aaaatataga ttacagccat 3053461 aaagagccgt tcttttgttg taaatgcggt tgcaagcgtc agtaaaaaca ggccaattgc 3053521 caacaccgca agcacagcag ccatctgcat gaaacctata tctttatgga tggctcccag 3053581 caataggacg actccaaata tagcagcggc cagtaacgct agcgtatgga ccgctgatcg 3053641 tttgatactc acatgtttaa cccctttcct gatgtttcag gagccggcgg ccgagcctag 3053701 cagccggcag cttcaaccaa gtaacacttt ttctttttat aaattgacgc ttcccaagtc 3053761 tttagccaat tcttcaagcg gcaagcccgg aaaatacttg tcagagggtt ccgttccccg 3053821 aacagcggga cggccgatag agtgataaat gtatccggct gcctgcatct cttcaagtga 3053881 aaataaattt ctgccgtcaa tgatgactgg ctgttttaag agggttttca cttttacaag 3053941 ctccatttct ttcacttccg gccaatccgt taaaatcagg catgcatcag tgtcttccat 3054001 cgcagcatac acatctgtgt aatactcgac ctgttcgcca aggatcgctg aagcttcagg 3054061 aatagcaatc ggatcgtatg cttttacatg ggcgcccagc tgctgcagca ttgggataat 3054121 atcaagcgct ggagcggatc tcacatcgtt cgtattcggt ttgaaggcta atcccaggac 3054181 tgaaatggtt ctccctttga cgcttcccat aacagtcaaa agtttatcta caatatgaac 3054241 acgctgcttt tcgttcgttt caatgacagc ttcgatgagc ttgaatggat agcctgccga 3054301 ttttgcgatt tgaagcagcg cggttgtatc ctttggaaaa catgaaccgc cgaatccaat 3054361 accagcttta aggaactttc tgccgatacg gctgtcaaga ccaacaccat cagcaacttt 3054421 tgaaacgtct gcgccgactc gctcacaaat gtttgcgata tcgttgataa aggaaatctt 3054481 tgtcgccaga aatgcattcg cggcgtattt aatcatttct gcactttcta ggtttgtttt 3054541 aatgacagga gcatggaatg gctgatgaag ttcctcaatg atggcagcgg ctttatgact 3054601 tgttgaacca atcacggcac gctccatatt catcgtgtca tgaatcgctg acccttcccg 3054661 aaggaattca gggttagata caacatcaaa tgagtatctc ccctttgagg ctttttgaac 3054721 gatagattgc accagtttcc ctgttccaac cgggactgtg cttttattta cgatcacttt 3054781 gtagccgtta agatgctcac cgattgtttt cgccgccgct ttgacgtacg ttaaatcagc 3054841 ttcacctgtt ttggacatag gcgttccgac tgcaatataa ataatatctg aggcccgaat 3054901 ggcagacggg atatcgttcg taaaggtcag gcgctgatcc agcacatttt tttcaactaa 3054961 gtctgcaagc cctggttcat agattgggat taccccattt ttcaggcttc tgatttttga 3055021 ttcatcgata tcacagcaaa caactttatt gccgatctcc gcaaagcaag tgcctgatac 3055081 gagtcctaca taacctgttc caatgacagc tatttttttc acagcgctca accctctcct 3055141 gtaaaatgat cttccaattt ataatggtcg cagtgtctta cgattaaacg gacgttttcg 3055201 tgaccgtctg atactgatga tgcaaggcct tggcgttttt tcctgcgtca aattgagcct 3055261 gcacggtttc atacaagtca tctgctactt ccggcttcca tatttgctca tgttcgtacc 3055321 gagtgatcgc ttccgccaag gcttgagcgg atttcggttt aatcagcaga tgttggtgct 3055381 ttccgaataa agacgacact ccgccaacat ccgtacaaat aacaggaacc cttagcgcca 3055441 gcgcctcaat cacaacagtc ggcatcccct cactgtaaga aggaagtacg aatagatctg 3055501 ccgcaagtaa atagtctctt acctgatgat tcgggacttg gcctgtgacg atatgcccct 3055561 tctgcgtcag cgtcgatttt gcgggaccat ccccgacaaa gactgcctta ggagagtcct 3055621 gcagcgattc gatcgcttca gacagttcaa aaatgccttt ctctctgacc agccggccga 3055681 catagacagc cagacgctga tcgagcggga gtccgagtct ttttctgatt tcctctttcg 3055741 tctcctcatt cccctgaaaa cggctgagct gtatgccgat tggcaaaacc gagctgtcaa 3055801 agcccgaaag ctttttggct tcttcctgaa gcttgtggct gactgctaaa acaactgacg 3055861 cagaacctac ggcacgcttg aaggctttaa acgcaccttt gctgtaatgc ggatagacat 3055921 tcacatcact gccatgcaag gtcaggacat aaggaatttg cgctgactct gacacgactg 3055981 ccgcagcccc gcccgatggc atggcaaaat gcgcatggat cagatccgga tataggtcgc 3056041 gctgtttcat tgtttttaaa acggctgatg cgattctccg atgaggctgc gcccacttca 3056101 gctggccggg aactgcccga tagaaaggcc ggtaaaccgg tatccccttt ctaatctcat 3056161 actccggtct gacatccttt tttcgatatg tctttttcag catgcggaca ggtgctgaat 3056221 gaaaaggccg tgggcatatc acagtgatat caagcccgag tttttgcagc tcttgcacct 3056281 gtgtctcatg aaacacaccc tctccgggtt tcatactgct cggatatacg cttgtgatcc 3056341 acaaaatctt catgacaaac gtccttttct tagtagtttg cttttcgttt gagggtacgc 3056401 ttttaccaaa agaaagagat agcacagcgc cccagccgca actgaaatgg ccagccgcat 3056461 ttctgcctgc atactgaagt gttcggtact gaggcttaca ccaaacgcga tgatgcccat 3056521 cgccgcagta atcagaaatg gcttcataat cgactggaaa taagctgaaa ggttaagctt 3056581 gatgacatat gccaaaagcc agcgcccaat caggaaatta acaacgctga taatggcata 3056641 cacccatgcg actgtcagca ggcttcccgt ctgtacagct gcaaacagtg ataatccgta 3056701 cagcagcagc acgccggaat cccaataaaa cgctaagtca gctcttcctt tagccagcaa 3056761 cacagatcca tttggattca tgagcactct tagtattccg acaatcgcaa gaacatttag 3056821 gatcggaaca gcagcaagcc atttttctcc gaaaaccgct gtgataaagg cgtctgacac 3056881 agacacgagc ccgattaaca gcggaaacga aacaagcgcc agcatttttg tcatattcag 3056941 aaagccttct ctgatcacgc tgttttcata tttgtttttt gcgaaaatag ggaatgccac 3057001 ccgtgtgaca atcggattga tcttcaaaac cggaatggtg acaatctgat aagcgaggtt 3057061 ataaatcccc aatgcttcag caccaataaa ccggccgatc aaaatcatgt cgatatttgc 3057121 tcccagcctg ttcacaagac gggatgaaag ctgaaaggct ccaaaagaaa agaaatcctt 3057181 catgcctctc aaatcaaaaa caaaagcagg atgccacttt tttcggtata cagcccaata 3057241 taaaatccct ttactggact gcagcaggac ttgagaaatc acgtacgcca aaatcgcatc 3057301 catcataaaa accgctatcg ctaaatatcc gaatgacaat acatttgaaa aaatctctat 3057361 tttgcttaac gtattaaaat gcagctgctt ttgcagcata tactgatatt gctgtccaat 3057421 tggcgcgatc aaaaacataa tcgccagaat ccgaaccaga aacaccagct cttctctttg 3057481 ataaaatccc gcaatgacag gactgctcac atataaaaga acaaacagca aaacgcccgt 3057541 cataatgtta agccaataca atgttgacag ctggcgctcc gtcgcgtcgt ctctctgaat 3057601 taatgctgcg ccaaaaccca tatcgagcac aatctgggcg aaaactgtaa ccgttgtgat 3057661 catgccgaca agcccaaatt ctgttaaggt catcatattt ccaagcaggg caaactgaac 3057721 aatttgtatg attgtaatac acatggttga aatacttgtc cactttgcac cgctcatgat 3057781 ttgttttgta atacttggca tcatattccc tacttctttt taagctcaga ttgatggtga 3057841 ataatggaat cccgttttat cttgcaccat cacccgtcca aactacttta caagttttta 3057901 acataatttt taattctaaa gtgaaagtca gattgcgaat gtaatataaa tcaaatatca 3057961 gcttttcctt cggcgtcata tcgtaaccgc cgttcacctg agcccagacg ctgtgtaaag 3058021 cctggaatct cattctggaa tttttccgta aatacgggcc gttccggacg agggccaatc 3058081 atactcatat cgcctttcag cacattaaac agctgaggaa gctcgtcaat tctcgttctt 3058141 ctgataaaag ctccgatcct tgtcacccgc ggatcttgct tctgtgccca aaccgcccca 3058201 gacttctcgg catctatttt catggaacga agcttataaa gcttaaatgg cttcccgcct 3058261 ttccctacgc gttcctgcgt ataaatggca ggccccggcg tctccaaaca aatcaaaatt 3058321 gaaaataccg caatcattgg cagcgcaatc gccaatccaa tgagcgcaaa ccaaatatcc 3058381 attacgcgct ttattgccaa ataacgagcc gtcttttcag ataatgtaaa agaatgtatt 3058441 tgttgaactg agaattcacg actcacattc atgcttttct ctgcactcac tgacacacac 3058501 ctcacgattt gtttgggatg ttatgatgac ctatgccagt cagtttagca gacggatgtt 3058561 aattggatgt aaatggtatg ttaagaagtg tgaattacgt gttttttctg ataaatgttg 3058621 ttaatactct tttactattt tatatacaag tcctatttgt tttaatcatt tcatataaaa 3058681 aagagacaaa tctgtgatta gatttgtctc tttcgattat ctgtaataag atactgtgcc 3058741 gtcatgaata gcttgtgcag ctttatcttt ataaaccgct tgcttcaatt tacttgcatc 3058801 tgatgcatta gtgataaagg cagtttcaac taaaacactc ggcattttag aatatttaat 3058861 aacatagaaa gcagctgttt ttactccccg gtctctcgtt ccaagattag ccgctaactt 3058921 tggttgaatt tgttcagcca gtctcttgct atttgcagct tgatatgttg tatcgtagta 3058981 cgtctcactt ccatttggtg atgagctatc attagcattt gcatgtatac tgagaaataa 3059041 atctgcttgt gcagaagctg ctttatttac tctctcctgt aaagaataaa aagtatcatt 3059101 agatcttgac agtactggaa gagcacctga agcatttagc tttgtattga ctcttttcgc 3059161 tatatcaagg ttgacttctt tctcaaggag tccattgccg attgctcctg aatcttgatc 3059221 accgtgaccc ggatcaataa agattgtttc acctacaact ggattcttta gctgattagc 3059281 aacctttgtg cttacggcag gagtgtttcc gataatcata aagtttgaca tgtttttact 3059341 tccaataatt ttacgggctc ctgtagataa attttcacca tttgtaagaa taagagattg 3059401 cttcttctta gctgccagtg tagctcctgc aatagagtca gggtagctga atccattgct 3059461 tacatatacg gtgcttgttg ataaattaag tttttgtacg atatttgcag caagctcata 3059521 tctgtttgaa ccgctaattc ttgtaggaga aggtaacttg ttgtataccg tattgctgat 3059581 acttccagtg cctcctacaa caacggtact cgaaattccc ttatctttta tcacagacgt 3059641 agtcgcacta tttatagatg ttttatttgt aaaaagaatt ggatacccgt ttttcgctgc 3059701 ataagggatg acggccggag cgtctgcata taagaagccg ttcaaaataa cagcttttga 3059761 agtcgcaccc atcgcttttg ccacccgtgc agccgtatca taacggttgc ttcctgcaat 3059821 tcgtttaata cttatcccca agcttttaat ctggttagca gtgttagaag aaacagcagg 3059881 tgttccgcct acaataatta catttttagt ctgcatctct ttcaatcttg ttttcgtttc 3059941 atatgaaagc ttatcagaat tagtgtaaag caatggcgca ttcttctggt aagcaagagg 3060001 tgctgctgaa atagcatctg cataggaact cccaccaaca attacagctg tacttgctgt 3060061 tgaatacatt tgctttgata tttgtacagc agtgccgtat ctattgcttc ccccaactct 3060121 tttcactgag ttatcggcca aagctgttgg cacaaaaagt atgagcccca gaaaacacat 3060181 tgttaggact tttatataag aacgcaattg atttcctcct taaatggcgt tatatcctaa 3060241 aataatcaat aacttgtcag agttgtacct ggatagtaaa atttcaaaat tgaactatat 3060301 gaatctccag cttctgctct tgcttttgct ccatattgac tcattccgat cccgtgacca 3060361 tatcctttac cgctgattgt gtactttgaa gtatcttttt ttacagtcac ataagtactt 3060421 ttaaatacag tcgctccaat cattgttctt aactcacttg ttggtacact aatggttgta 3060481 attttgctca agttatagga gccagtactg cttttaacaa aatacttcac tttcatcgat 3060541 gctgtttttg cacgctgccc ttgtgtcgtt ccactaaagc ttaaatcgtc aatacttgca 3060601 attttgacag aatcagcgct tgtttcttta tttttcaaga tccagttctt aactccggaa 3060661 agtcttgcag aatcagtttc agtcgctgaa gaccaccaag aagaaggctt cgttaagtcc 3060721 aaagatttcg tatctagctg ttgttttgac aaagtaagcg tccagcctat ttgaggatcc 3060781 tttgtatctt tttttgcaat caagtaaggt acacttgacg accacacttc attactagct 3060841 tctgtgtaac caccattact ggaagaataa gctgcagtta taagagatcc attatatttc 3060901 agaactttcc ccttcgtttg ctctaccgct ttattggtat tcgaattcca actgtagcca 3060961 ccataaactt gaaaagcggt tgtatcaggt acagtagttc ctgtttttgt tattgagtag 3061021 gttcttgcag cgacagtctg tgctttaaga gcctcaagtg accagctagc aggcatttca 3061081 ttcggaatta ctccttttaa gtaatcctca aatggaatat tctcatttac cggtcggata 3061141 tatttagtag actcaataga gaaattaacc gtgccaagat actgctttcc atcaagacta 3061201 attctgtttg aagtagaata gttttctggt ttaattctta gggagtttcc gtaagttttg 3061261 atgttttcaa ggtttaattt tccgctgttg atttttagat tataggtgcc accgtcagct 3061321 aaataaaatt catcagcaag tgaattctca acttcagcag aaattgaact ggtacttcca 3061381 ataaagtcgt atgcatatgt ggctttatct ttcgttatac ttttagccgc agccggaacg 3061441 ctatcttgtt taacaaataa aatttggctg tttttcttcg aggcaagcga agcgcctatc 3061501 aatacgtctg catattttgt cccgttcgtc attacgactt tatcagcctt caactttagt 3061561 tgcttaatta tatttgccgt aagttcatat ctggttgatc caggaatcct ttgcacagtt 3061621 gaagtttttt taatttggtt ttctacacta tcactgacgc taaatgaact gcctataatg 3061681 atgacttgtt ttggcaaatc ataatccgga agcttgtctt tctctgtaag caaaataggg 3061741 tatccgtgtg ctgctgcata tggagcaatg gctaaagcgt cttgaaatac tcttccggtt 3061801 acaacgatcg ctttatcata gctgcccatt tgctttgcaa tattttctga taagacatat 3061861 ctattttttc cgcttatcct tttcacagcg ccatatgatt tcagcttgtt ttctacgtct 3061921 tttgaaatgc ttcgcgctcc cccaatgatt aaaatattat cagggttaaa cttagcaatt 3061981 tgtctttcag tagtttttgt taacgtgtca ggctgagtaa ataaaactgg tgcgttcagt 3062041 tttttcgcca atggaataac aggcaatgca tcaataaaaa tatctcggtt caccaatatc 3062101 actgtattag gatttttcca ctggctgttg gatgcaagag tcgcagtttc gtatcgtgaa 3062161 gcgcctgcaa aacgatccgt aacagcaaca ttatctccag ttactttata aaatcctgtt 3062221 ggcgatagac tgatgctaga tttatttcca atataattta acaatttaac tgagatgttt 3062281 gagtctgctg caaaagaaac tgatggaatc aataataaga ttgcagcaag tgaacacact 3062341 atcaattgtt tgcaagattt caaaatttca ggttcctccc tatatcttag ttggcacgtt 3062401 caatatcttt taacagaagc tgaccctcat catttttttc atatgtaatc gtgaccttat 3062461 ctccactgtt aaacttatca agatcacttg tcgattcttc agtgatatca agactaaccg 3062521 gctcattatc tactgttact tctattgtat gagtatcagc taaccctaca taagtacctt 3062581 cttttgtttc aatgttactg tctggcgata catcttcacc ttgactcttt tgactattaa 3062641 ccccgcaacc cgaaagaagc aatataaaga acagtaaagc aataaatttt ttcatttttt 3062701 tcacctcatt atattttatc gtcaacctat tttatatttt aaagaaaaat taagaaacaa 3062761 tgaaactttt ttttataaaa aacgactatt ttaggatttc attcttgtat taaatagagt 3062821 tgtatttatt ggaaatttaa ctcataatga aagtaattta acagacgagg tgcaaaggat 3062881 gagaaacgaa cgcagaaaaa agaaaaaaac tttattactg acaattttaa cgataatcgg 3062941 acttcttgta ctcggaactg gcggctatgc atactactta tggcataaag cagcttcaac 3063001 cgtggcaagt attcatgaaa gcattgataa atctaaaaag agggataaag aggtcagtat 3063061 caataaaaaa gatccttttt ccgtcttaat catgggtgtg gatgaacgcg acggcgataa 3063121 gggccgtgcc gatacgctca tttatatgac cgttaaccca aaaacgaata caaccgacat 3063181 ggtcagcatt ccgcgtgaca cgtatacaaa aattatcgga aaaggcacaa tggataaaat 3063241 caaccattca tacgctttcg gcggcacaca gatgacggta gacactgttg agaacttcct 3063301 cgatgttccg gttgattatt ttgtgaaagt gaacatggaa agctttagag acgttgttga 3063361 tacacttggc ggcattacag ttaacagcac attcgcgttc agttatgacg gttattcgtt 3063421 cggcaaagga gaaatcacgc tgaacggaaa agaagcgctc gcttataccc ggatgagaaa 3063481 agaagatccg agaggcgact tcggacgcca ggaccgccag cgccaagtca tccaaggtat 3063541 tattaataaa ggcgctaata tttcttccat cacgaaattc ggagatatgt ttaaagttgt 3063601 tgaaaataat gtgaaaacga acttgacctt cgataacatg tgggatatcc agtccgatta 3063661 caaaggtgcg cggaaacata ttaaacagca cgaactaaaa ggtacaggca cgaaaatcaa 3063721 tggaatttac tactaccaag ctgatgaaag cgccctttcc gatattacaa aagagctgaa 3063781 ggaaagcctc gaaaagtaaa acaaaaagaa gcttcgcaca atgtgcaaag cttctttttt 3063841 atttgcctgt aaatgaatcc ggttgttctt ttcgataccc gtaatgaaac agcaattctt 3063901 ccacaatccg gcgggaagcc tctccatctc catacggatt agaagcctgg gacattttct 3063961 tgtactcatc aggatcagtt aacagctgtt ttgcaagctg ataaatgttt tcctcatccg 3064021 tacctgcaag tttcagcgtt cccgcttcca ctccttcagg ccgttccgtc gtatcacgca 3064081 gaacaagaac cggtttcccg agagatgggg cttcctcctg cacgccgccc gaatcggtca 3064141 atataaaatg cgatttcgct gcaaagttat ggaaatcgat cacctctaaa ggttcaatca 3064201 gatgcactct gtcagaatca ccaaaatgct tatgagccgc ttcccggaca acaggattca 3064261 ggtgcacagg gtaaacgact tgtacatctt caaattcccc tacaattctg cggatggcct 3064321 taaacatgtt ttccattggc tcacccaaat tttcccggcg gtgagcggtc aagagaatca 3064381 ttttatcctc acccacctga tcgagaacag gatgtgagta accatcccta accgttgtgt 3064441 tgagtgcgtc aatcgctgta ttgcccgtta caaaaataga gtcggccttt ttgttttctt 3064501 ttaataaatt gtctttcgcc tggcctgtcg gagcaaaatg caaatcagca atcgcccctg 3064561 tcatctgtcg attgagctct tccggaaacg gggaatactt attccctgta cggagccccg 3064621 cctccacatg accgacagca atttgatggt aaaaagcggc taggcttccg gcaaacgtcg 3064681 tcgtcgtatc accatggaca agcacaatat cgggtttgat atctttaaac aactcatcca 3064741 atcttacaag tgcgttagac gtaatctctg ccagtgtctg ccgctccttc ataatgttca 3064801 aatcgaagtc aggcttgatg tgaaacgcat ctaacacctg atcgagcatc tgtctgtgct 3064861 gtgcagttac cgttacatag gaatctattt caggatattt tttcaattca agcacaagcg 3064921 gtgccatctt gatcgcttca ggcctggtcc cgaaaacggt catcactttt agttttttca 3064981 tatttgtcac ctggttttct gctatagtaa ataaattcat actacatatt ctacatgaaa 3065041 atgcatcatt ttaaatcatt tcattcttga ttcaaataaa atgatataag ttttaatatt 3065101 aaggataaag cttgtttaaa aatggtttat ccgatatcat aaaaatgtgt aaaaacatat 3065161 tgaaaagggt aaatagagaa tagtttaacc ataaattttt tcgatcataa ggaaggtgcc 3065221 ttttaaatga aaaaagtacg taaagccata attccagcag caggcttagg aacacgtttt 3065281 cttccggcta cgaaagcaat gccgaaagaa atgcttccta tcgttgataa acctaccatt 3065341 caatacataa ttgaagaagc tgttgaagcc ggtattgaag atattattat cgtaacagga 3065401 aaaagcaagc gtgcgattga ggatcatttt gattactctc ctgagcttga aagaaaccta 3065461 gaagaaaaag gaaaaactga gctgcttgaa aaagtgaaaa aggcttctaa cctggctgac 3065521 attcactata tccgccaaaa agaacctaaa ggtctcggac atgctgtctg gtgcgcacgc 3065581 aactttatcg gcgatgagcc gtttgcggta ctgcttggtg acgatattgt tcaggctgaa 3065641 actccagggt tgcgccaatt aatggatgaa tatgaaaaaa cactttcttc tattatcggt 3065701 gttcagcagg tgcccgaaga agaaacacac cgctacggca ttattgaccc gctgacaagt 3065761 gaaggccgcc gttatcaggt gaaaaacttc gttgaaaaac cgcctaaagg cacagcacct 3065821 tctaatcttg ccatcttagg ccgttacgta ttcacgcctg agatcttcat gtatttagaa 3065881 gagcagcagg ttggcgccgg cggagaaatt cagctcacag acgccattca aaagctgaat 3065941 gaaattcaaa gagtgtttgc ttacgatttt gaaggcaagc gttatgatgt tggtgaaaag 3066001 ctcggcttta tcacaacaac tcttgaattt gcgatgcagg ataaagagct tcgcgatcag 3066061 ctcgttccat ttatggaagg tttactaaac aaagaagaaa tctaaacaaa aaggctattg 3066121 gacattcatc caatagcctt tttttatttc aacatcaaag tcaatgtatg ctcttcatta 3066181 tcaactgcga agacctgatc aacggcctgc cgcaaaaatt aataatccca gacaaacaca 3066241 ctgattgtag agttaaacaa actaaatgaa aacataaata caaacatgca gattaaatag 3066301 taaatatctt gtattcaatg caagctaagt aaacaccact tgctaaaaga acaatgacta 3066361 aacaaccagc attacaaaat aattaaataa atttgaagca attacaacag aaggcagtga 3066421 actgtcggaa agttcatttt ggctaccata ttaatccctt taactacgct gttggattta 3066481 tcaagaattg tcgggctaat agaaaaccac ggaatcaaac cagccagcat tcaaacgata 3066541 aaaggcactt ctccgatacc tgttatgacc agcttactgt tgcgcatccc aaatacaaac 3066601 cagtacgcca tcattagaat aaggggattt aaaacctgcc ataatacacc aaaataattg 3066661 attttttgga tctttcggtt aaagaaattt aaaagtacca gtgaatattg taacaaatgt 3066721 tgagtttttt tcacttttaa aaagtaaaga gaagtctcgc agaacttctc ccaacatttg 3066781 aagtgtcaat ataaaacaaa ccaacctcat ttagcaactt tattattatc taattccaaa 3066841 atagcattat aaatacgatt cctattattt ttatcagtat atgcaaaaaa gttatctact 3066901 ctttttctat acttatcttc catacgacta ttgtttttca tataatagat aactttatcc 3066961 actaagctat tatgattttc taatacatca ccaaacccca tttttttata atcataataa 3067021 tcaagtttaa aatggtatga cttttcgtat tgataataaa taacaggttt tttctcatat 3067081 gcaaaatcaa acgcaacaga tgaaaaatca gtaatcatta tattagaaga attaaatagc 3067141 atttgatagc tgctgttata gtcggcaaac tccacataat catgcttttc aaagtctaca 3067201 atctgttgct gaatatctgg gtgaggaaaa aaagttattt tataattatt tttcttagca 3067261 aattcgatta gccgttcatc attaatcaaa gcattatacc tagaaaaata ttcactatct 3067321 ttaaatttcg ggttgtacgg tcttactcct tttgcctgat ctttcggtaa tacaatatct 3067381 tttctccaag tcggcattat tagaagttgc ttttctccct cactcttctt aagattatcg 3067441 tatctcggaa atccacccaa caaaatattc tcttttttat agttgtaatt ccctttcaca 3067501 atagaccgat attcaggttt ggcagaagtg actaataatt tgatattctt gttgtatttg 3067561 tttaaccatt cagaatgatc tgccattgtt attccgtgct gtaaaaagat aaactcaaag 3067621 ttaaataaat ctctaaaata aatctccata ttaaaaaatg gatttacaac ccatatatct 3067681 gcatgtgtcg atattacttt ggaagaggat aaggttaaaa ttttatgtct aaaagatctg 3067741 tatggtatga cctttccata ttttttgatt ctgtcgtaat ccttgctatc tttttttatt 3067801 ataaagtatt tttttacccc atcattcttg ttgattgcat atttaaagag gtgctcggca 3067861 ttatcatcag ctttgtcttg tctgtctatg aataaccata ctggttttct attaaaaata 3067921 gtgaaaacat ggtgtaccat tcttgccatc agtgccttct taatcgctga ttttcgtttt 3067981 tttgattttt cccctgattt atgtagggat tttaagaaac gaaactcttt tataaatcta 3068041 tttttaaaat tgtttttttt gaacattaat tttttataat tataataaaa aatataatct 3068101 tttttagcca cataagtatt atataaatcg tttgacaaac ctgaatactt gaaaaaacga 3068161 agttttgtca acttcctttt tttaccctta gttataaaaa actcaatatg atgattatct 3068221 gctagatgac ctttgggaat atctattgaa aaaccgggat atttttttat tacttctcct 3068281 aaacttatat aatcattatg ctgtcttttt atattctttg cttttatttt tgtttcgcca 3068341 attttagcat aaaacttaaa acctttagaa ttaaacagcg agctccaaaa gccttctatg 3068401 tgaatggaat cctcattttc ttctaaaatt tcaatagtta aagtttgatc cgataatttc 3068461 gaaacaattt taccttctct gtataaataa taatcctgtt cagtttctct ttcatataca 3068521 tacctactat aattttcacc gtgctttatt tttaaagcat gatataaata gaaatggctg 3068581 acactttttg tttcaatgat gacatcgtcg tcaatatacg acaatacttc tcgaatcaat 3068641 gttaaaaatt cactgtattc attttcgtct aaaggtgttt cactgatatc cttaatcaat 3068701 aatttccact tcaaatcatg cataaccata tattgaagaa ataaaggtat tttctgttca 3068761 tgatttttta taatatcgat taaattcttt gagaaagtga taagtgaatg gttaaaccaa 3068821 ttcttatttg ctttagcagt ctgcatggca gatgatccat cttctctaac tctataatgg 3068881 tattttgcct ctttaaccag accatacttt ttcttttgcg atatgattaa attaactagt 3068941 ttggcatctt cacctatttt acaattttca tcaaacctga tatttttcaa ggcatctttt 3069001 tttataaatg tagaacaaca atgagttaat atatgatgcg gttctttttc tacatccaaa 3069061 attcttgtag aagaaaactt attatttaga ttatgttctc cagttcttcc ttctgcaaaa 3069121 aaaataggga ttgctacaat atcaatttca ttcttatgtt cgtcaaagaa gtttaaaaca 3069181 ttttcgaatg ttccttctga aactaaatca tccggatcca aaaattgaat atatctacct 3069241 tcagcatact ttaaaccata atttcgagca ctgctcactc cgccattctg tttctttgca 3069301 tagacaatgt tattgggata tttctgagca tattctttac aaatgatttc acttttatcg 3069361 gggctatcat cattcaccag tattaactga atattctcaa aaccaatagt ttggttaatg 3069421 atactttcta tagcttcagt gagatacaac tcaacattat aaatcggcat tataacactg 3069481 aaatcatagt taaaactttt ttcgttcata aaagattact cctaacataa tgtttatatg 3069541 aataagaatt cgggtaaata aaattaagaa acaagagagt actaattttt gcaaaacaat 3069601 tttaatttag taaaatgtat gaaaagcatt ccttaccttt ttttaaaaac ccttgtaagc 3069661 aaacttttaa aaatgttcac atggttaagt tctaaagaat catttggtgt ttttagtaca 3069721 aagtcaaatg caaaggccca aatcggtatt tcgacaacaa aaccagcata tctaaaatct 3069781 cttaatttat atccccatac ttcaattgtt tttttcagtt cttttcgttt gcattttttt 3069841 aatcttttaa aatattttat atatattctg tcattttctt tcatctcata atactggtta 3069901 ataaagtgcc ctgttaattc aagtctaagc ccttttattt ttgccgaagt aacagtacat 3069961 gaactatgca gtactctttc tttttttata ttttcaagag cttctgtatt ttcttttaat 3070021 aagtgaaaca taaattcttt atagtacatc ggcatatctt gttcttttat aaattgcggg 3070081 tcaataaatt ttaaaacttt aataaaatca tcaacaaaaa ctctttgttc ttgttgatct 3070141 aaaacagact tataaacatc tctatagttc ggatataaaa acagttttat atgatataca 3070201 attaaaaatt gcaaataagg caaaactata tcatatttgt tgaatgaatc catcaacaaa 3070261 gtcatgtaac attcattcaa caaatatgtg tacctttttt tgttaaacca tgaacgatca 3070321 actaaagaat cctgttcttt ccgttttcta taaaaatact ttccttctgc aactgctccg 3070381 tatctttttt ctttcagtaa taactggtta aaaaagatag cgtcttccca aaactttata 3070441 gattcatcaa aaaggacggt actagttagt gtatgtcttc tgtaaaaagt gccgccaata 3070501 taaaaatgaa tagctttata atcgttgaga atatttataa ctcttgttcc tttttcaaat 3070561 ctattattta atttatgtcc cccttctttt tcacctgtgt aataaacagg taataccgca 3070621 atatttacat gttcggaatc acaaaaaaaa tcataaacac tttgcagcgc attttgagag 3070681 aatgcatcgt cagaatcaag aaaaccaata aatttagatc tttcgcttac atttgataat 3070741 ccacaatttc ttgcagcaga aggtccagag ttttcaattt tcatgatttt aatattatta 3070801 ggatatagat ttttaaagga ttcacaaatt tgaggactgc tgtcaacact accatcatct 3070861 attaatatca gttctatatt ttccttaaat ccaattgact ggttaaggac actctctatt 3070921 gaatatctta aataattttc agaattatat attggtataa ttatagaaaa catgtttgta 3070981 cctctttatt tagaagttaa aggatcgttt caattactct tttagaagcc ttgcctcttc 3071041 taaattacaa aatttattat aaaaatcctc atagttatga tctatataag gattatgtaa 3071101 caactctttt accgtatcta taagttcttc acttgtttga agcaagtttc ctggcgtttt 3071161 ttgctgaaaa ttaaagtaaa aacctctgat acagtctcta taagccggga gatcatacac 3071221 aaaaaataca aggttttttt aaaaattcat attatcaaaa aagacagaag aataatccat 3071281 aatcaataaa tcactaatta aatataaatc tcgaatatct ttatttaaag aaacatcgtt 3071341 cacaaaatat ttatatttcc ctaattaaat tgttctgaaa ctggataata ccattcttac 3071401 aagaataacc atagagtctc caaggttccc tcttcatttc ctctaatcaa attaaagtta 3071461 aatttatact ggccagcttt cttaaaattc attatcccgc aaagttggtg catataaaat 3071521 tatttttctt taattcctta tttgataatg tagaattggt aggggattgt agctaaactg 3071581 tttccagaat agctttcaaa taaaattaat ttattgtttc ttggcagaag gacaaaaatt 3071641 ttaaacaaaa ctgaataaac tctaactagt aaacttctgc aattggttat aataaaaatt 3071701 tcatcagtga actccttaaa gagtgaagat taatatttac gcaaacaaga aaaaaagaag 3071761 caactgaatt tacttcaagc ctcttttagt tagtgcttct ataaactagc catatctttt 3071821 ctgatttggg tagttgaaat gcctgctatt cttgtaaggt aaatggcctc atagtattcc 3071881 tttgtagaca atcgtacgat taagtaatcc caggttcttt tgctctttcc agtagcttca 3071941 tatgtccata gtgaaataaa tcaaacattc cgtacgtatc actttcttca ttagataaca 3072001 tcaccttcca accttttcca acttagaaaa aacaaaaatc cttaactgat tgtttatcat 3072061 ttcgacatat tttttacgtt ccattaataa taaacaataa tagcatatgt tcctataaaa 3072121 gttaaggctc tttaaaaatg taaatcatca gcactttttg acaatatcgt tgcattgatg 3072181 tgtatttttt acagatctga tatcttatct atactcatta caacaagttt tctattccgg 3072241 aagagtcaat tctttttgtc gcgttttcaa gtgtaatgat tttctttctg ctgcgtcatt 3072301 tattttgtac gccctcctca tattacttca tcgtcaaaac gtgaaggaat tgtaatacgt 3072361 agttcctaaa aattttcgtg gtaaaattta gtgaagtctt tatcaggcta agggacttta 3072421 tctaaactac gaattacata tggagatata tagatgaaaa ggagggttga tatgatataa 3072481 acgaaaatca attagataaa ggaaaaactg aacacttctg aaaaaagtga taagtttctt 3072541 tcactatatc ctccaaaaag aacctaaagg tcttggacat gctgtctggt tcgcgcctaa 3072601 ctttatcggc gatgagccgt ttgcgtttct gcttggagac gatattgttc aggctgacac 3072661 accagggttg cgccaattaa cggatgaata tgaaagaaca ctttcttcta ttatcggtgt 3072721 tcagcaagtg cctgaagatg aaacacactg ttatggcatc atcgccccgc tgacaagtga 3072781 aggccgccgt tatcaggtga aaaacttcat tgaaaaaccg cctaaagaca cagcaccttc 3072841 taatcttgcc atcttaggcc gttacgtatt cacgcctgag attttcatgt atttagagga 3072901 gcagcaggtt ggcgccggcg gagaaattca gcttacagac gccattcaaa aactgaatga 3072961 aattcaaaga gtgtttgctt acgattttga aggcaagcgt tatgatgttg gtgaaaagct 3073021 cggcttcatc acaacaactc ttgaatttgc gatgcaggat aaagagcttc gcgatcagct 3073081 cgttccattt atggaaggtt tactaaacaa agaagaaatc taaacaaaaa ggctattgga 3073141 cattcatcca atagcctttt tttatttcaa catcaaagtc agtgtatgct cttcattatc 3073201 aactgcaaaa acctgatcat ctgtattcac aagaaaacgc ttcttgctgc tgtcatacaa 3073261 tacatcgcta tcacttaagg atagtgacgc cgggttgata ggagaaatgt tatgaaaaat 3073321 aagctctgtt gctttatcat tctccagtac ataactgatt ttttcataat caaaattcag 3073381 cgtttttctg ccgtcagcct tatttccttc agtataacca ttcaatttcg attgaatgct 3073441 ggtgctgctg tctcctagga atttcagaaa gtattcatag gaagatgctg cgttttgcga 3073501 gacataagac gtaaatgcag tggcatgcaa ttcagcgtgt ttcatgttag ttgcaacagc 3073561 gctctgtttc acataataag agtgcccgtc aaactttatt ttcgctgctt gtttgccttt 3073621 tgcagctacc gttacttttg taccgaatgg cagtgtaacg tcagccttct gtttcaaacc 3073681 ctgatcctta taagcagccg ctttttcatt tgctataaac ccttgcttat tgattgcagt 3073741 taagcgttcc tctgacttgc cctttgcatc gccatgatgg ttcttcactt cattttgcgg 3073801 aatagcgcca aacgaagcaa ttgtacgaag cggggcatta aagaacatcg ttcccgccat 3073861 gaagacagtc agaatagaca aaatagcaat ttgaatggca ttggccagtg atttcggctt 3073921 tttcttcttt ttgcggaaac gggcaaacgc ttcaggatct tctttcttcc tctcttctgt 3073981 ctgctctttt ttatatgtct ctttttcttt tttcgatagc ttattaaacc agtcaataaa 3074041 cgctttgtac tctttcacaa ccgtttttgt ttcatcaaac atacgaagct cgccatagtg 3074101 catccaagca acacggtcac acatcttttc aatctgaccg attgagtggc tgacaaagaa 3074161 aatcgttttt ccttgctttt taaactcatt tattctgtct acacacttct gataaaacgt 3074221 ttggtccccc acagaaagag cttcgtcaat aattaaaatg tcaggatcaa tatgcacgga 3074281 gatcgcgaaa ccgagacgcg acttcatccc gctggaatag tttttaaccg gctgattaat 3074341 aaaatcgcca atctcggcaa attcaacgat gctgtcatac atatcatcaa tttctttatt 3074401 ggttaacccc atcatcaaac acttgagccg gacattgtcc cggcccgtta attggttatt 3074461 caaaccggca gcaatcgcaa tcagcgacgg ctggccgttc atttcaattt caccgctggt 3074521 cggcggaata attttagcca gcaggttaga catggtcgat tttcctgacc cgtttattcc 3074581 tacaaagccg attgtctccc cttcatacac gtcaaaggag acattccgca cagcaaaaaa 3074641 accattatcc ttagccggaa aaaacaatcc tttaatcttg tccgattgtt ttttatacaa 3074701 atgatactgc tttgaaacat ttcgaaacga aacttttagt ttcatcgtaa aatctcctta 3074761 cgtattaaag aaagtcaaca aacttgtctc tgaatttcat atgcaggata gaacctacta 3074821 acaataaaag gaatgtgaac aaccaaaagt acagcgtgta cttcatgtca tggaaaaacc 3074881 atgctccatc taagaagctg ttccggaatc cttcaataat atagaatagt ggattcaact 3074941 tcagaacagg cactaattcg gggtggcttt gaccgagttt cgcattaaca tcccaaaaaa 3075001 ttggcaacaa gaaaaacaaa agtcttgtta cggcctgcag caaaaattga taatctctaa 3075061 tcagcacact gatcgttgag ttaaacaaac taaacgaaaa cataaaagca atcatacaga 3075121 tgaagtaata aatatattgt aaccaatgca cactcgggaa cacaccatta actaggagta 3075181 caatgatata aatcaccatc atgatcatat aactaaataa gttagatgca attgccacgg 3075241 acggtagaga actaatcggg aagttcattt tagccaccat attaatgcgc ttaaatacac 3075301 tatttgatcc atcaagtata gttggactga tgaaaaacca tgggattaat cctgccagca 3075361 tccaaataat aaaaggcact tcgcccgctc cggttgtcac aggaccgccc tttctaatcc 3075421 ccataccaaa tacgaaccag taggccagca tttggataag cggatttaag aactgccata 3075481 agacacctaa ataattcatt tgatatttag acttggtttc ataagccgcc aatcttaaaa 3075541 ttaaaggaaa tgacgttatt tgctctctga gtatacgcaa caaatcattc attttttatc 3075601 ttccttagac ttaattgttt ttgggaatct ttctgtttaa aatttgaaag caccgctgat 3075661 tattgtaaca gatcctgcat tttttttcac ttctcaacaa gtatctaaaa agctgccgaa 3075721 aaatcgacag ctatacattt tataaaataa cctaaattat tcagctttaa atacagtatt 3075781 aacaaccttt tcagatgaac gtcctgactc taaatagcaa aacttatcat agaaaggacc 3075841 aaaagaaacc ggaagcttat aatcaggcga tgagatctgc ttgatagcct caatcgtttc 3075901 ttcagtagtt tttaccaaag gaccaggagc ttctttttca aaatcaaagt agaaaccacg 3075961 caacttgtcc cggtaggttt cgatgtcagg gacaaagaat agcattggcc gttttaaatt 3076021 tgcaaaatca aagaatactg aagaataatc agtaatcagc aaatcagaaa ccatatacaa 3076081 ttctcgaata tcctcataag cagaaaaatc atatgcaaat ccttcaaaag gacctaaatc 3076141 aaaattctca gctaccagat aatgcattct taagattaca atatattcat ttccaagttc 3076201 ttgtctaagt tgatgcaaat ctaaatcgag atcgaactta taacgccctt ttgcatagaa 3076261 ctgatcatct ctccatgtag gggcatataa aataaccttt ttatcacgag gaatatttaa 3076321 cctactcttt atcaatgata ttgtttcctc attattatca ttatgaagaa aatcatttct 3076381 aggatatcca gattcaatca ttgtcttgtt aaactgaaac gcccgtgtaa agatctcagt 3076441 tgaataacca tttggggaaa tcaagtaatc ccaattagaa gcttccttga taaaattcct 3076501 tttatatttt ttggtgtttg taccaggcat atggacttct tccatatcca ttgcaagtct 3076561 ttttaaaggt gtgccatgcc atgtttgtaa atatgttgta tgactaggtt tcggaatcca 3076621 taatggaagc cggctgttaa caacccaata ctcagctctt gccatagcga agagccattt 3076681 taatgagagg cgattaatgt aaggaattcc cttttcatca aaaggcgctg aatattgttt 3076741 atttacactc caatacattt tatactcagg gtggttttcc cgcatatatt cgtaaatcgc 3076801 tctcggatta caactgtatt gtttcccatt aaaactttca aaaatgactg ttttcctttt 3076861 aactggcatt ctgctagcca tcatgaatag agatttgtat gttttagtga ttaacttgtt 3076921 tctcattttt gtgatctttt ttatttttga tactaatctc ttcttctttc ctttaataaa 3076981 gtatttcatc cttgttttca ggctatagtc gtttactctg atacctagag tctgcttttt 3077041 ctttttctta aagacttcat aacgaactgg tgcgttgttt gttttaataa tacttactaa 3077101 tccttttaat ttgttttttc gatctcctaa aacaagagca gtgctgttga actgaatatc 3077161 cgttccttca tcgtcattgc atatatactc cataaaaaga cgataaacat aacgtttttc 3077221 atttgagaaa ggaatttctt tcaaaggcac tttcacttca aaatcataca gttccggaac 3077281 aaaaccatct gctctcatgt tttccaggcc atgtgttttt ctttctagct tgattggaaa 3077341 tttttcctca ataggtgttt ctccaccctt ttttaaaata aggttcaagt tttttatccg 3077401 atattgattt tcggaactca ggtaccccgc ataacctgtt atgcttattt cttcagagct 3077461 aatctcgatt tgatcaaatc tgatgatttt ggcctctctt ttcaccttaa tagaaaagtt 3077521 gcctttatca gttgtataag gtaaaatcaa aagttctgtg gtttgatcga catgaaaggc 3077581 gcgctcaatt gaatttactt cagcagaaag acgcttcaag agtggttcct gctccgcatc 3077641 ttcatatttt tttcgaaatt cgacataaaa atcatatgtt tgtcccattt caacaggcat 3077701 aggcaaaaca tgagcattta tctcagtttt atactctaat gagccagtgt tttgaagcgg 3077761 aaattcagat tccgttcctg aacgtctctc tttcagcttt aaaaataact ggtaatcctc 3077821 taaaaattgg tgttctgaat caattgagat taacaattca agacttccta aattgttttt 3077881 caagcttttc aaaatacatt taatcacagt gttttcaatc attacttttt tctgctcctc 3077941 tgtataaaag ctctttcctt tttgcttcct tttattagtg tcaactacta aggacattaa 3078001 ctctctttta tttccgtgac cctccaagag aaattgcctt taactgttgt atagggctct 3078061 actctatagc cattattagt atctatactg tttcctgaca attttgtttc ttcactcgaa 3078121 agtcttcgca ttgttttaat atggccattt gcattgaaaa caatataaaa atcaataact 3078181 tgggttttat tagcagctat cttttcaata tttacatctt tttcgagatc aattacaaac 3078241 agttgatcat tttgtaagtt tgttgaaata atttcagcct tattctttct gtccaagccc 3078301 actaaacgta tttttttaat atcattatga tcaaaattct caatgtcaat ttctatttta 3078361 gttttatcaa aatcctcagt ataggaacta atagaaggat ctttttttcc aaccttttta 3078421 gagaacttct ctctttctat tcgcacctca atcatctgat taagagcaaa agcccaattt 3078481 tcaatatagt tgggtcttga atatttttca gccattttaa aagcttgttc tgaaaatttt 3078541 tgatgagtac tttcatcttt catcaaagag ataatagctt gacccaattt ctctatatta 3078601 tactgttcaa tgacatatcc atttgctccg tcagtaacta agctccttgc tccgtaatca 3078661 taatcgtatg ttacaactgg acatccattg ctcagtgcct ccatatttga tagaccgaac 3078721 ccttcaaaat gagaggttga aatggttagc caagcttttt gaaactctga gtcagggtta 3078781 tccgtatagc ctttcaaaaa gacattgttc tgcagtttgg tatcttcaat ttcttttttt 3078841 attttttcga aatcttcacc cgatccgaat atatcaagtt ttgcttcagg aatttctttc 3078901 acgactaaac taaatgcttt tactgcatgt atcagatttt tcatagatgc aagtcttgaa 3078961 ataatgacag ctttgtattt ttcactcggc acattcaata cagcgggatc aagaggctta 3079021 tcaattgtat gcggagtaaa gaaaaacgtc tcttgttccc ctgaaatcaa tttaaaatct 3079081 tctagctgct cctcagttat aaaaaagaca gcatccaaat tatacatctg actaaatact 3079141 tctttatagc gacccttaat ttgatattta ttgctgccgt aatgcttgtt atgaataatt 3079201 gctccataat aggaagaagg tgattttttc actttaaaga catgtttgtc ttgcggtctg 3079261 ctgtccacta aaaacaactt aggtttatca ttttgttttt gcagatattc tatccaatat 3079321 tgacgcagtt ccgattcatc ttttactttt atctcaccct caagggagta ccaaataata 3079381 tgagataatt gaacatcttt ttcttcattg ttccatacat agagtttgtc taaatatact 3079441 tgattttggt cattaatata ttcctgcaga tacatcttgt ttagctgcac atcataatga 3079501 gtaacgagaa ctaagtttcc gttcttcgta tattcctctc tctttatgag ctggttttta 3079561 tcattccaat agtcgacgta ccggatagtt tctccatctc cgtagtaaac tacagacatt 3079621 tcattgttct tcttaccaaa caatctcaac agagtttttg caaatttccc cattccaact 3079681 tgctttttta tctggtcaag gcctatcctt tcttcgtatg atcttttccc atttgttcta 3079741 acacttaaaa aatcatcgaa tagattaata acacttgtga attttttatc aatcttaccg 3079801 ttgctgtaca attcatcaat ttttgaagac aactctaaat caaaacgaaa cgttaagaaa 3079861 aaggtgtttt ggttacactc ttctccaaat aattttgaac gcaataataa tgatttcgtc 3079921 agaccgccat aattacttgg cagtccacca gagataaaat aataatccat gtcaggaatt 3079981 tgttttatat tagattcact caccgcatgt aaagacaatt ttttactccc tttcggcatc 3080041 tagaatatat gatcattgaa atttatatct acccggatac tttagtcaca aaaatcaatg 3080101 taagcatcaa aaagtacttc ttatttcaat aagaagtact ttaattagat attgaaccaa 3080161 tgatatcagg atcctaaatt ataaaccagc aatttcctct ttgatctttg ttgtagagat 3080221 gccttctgtt cttgggaggt aaacaacctc acactgatct ttgagaaagt caaatttacc 3080281 ttcccagtca tcccccataa caaaaacatc aatattatga tcaataatat cttgcttttt 3080341 ttgctcccaa ttcttttcag gaattacttc gtccacatat cgaatggttt ctaaaattaa 3080401 tttacggtgc tcatagctgt gataagcttt tttttgcttt tgtaaattga attcatccgt 3080461 tgaaatagca acaactaaat aatcaccaag ctgctttgca cgctcaagca atttaatgtg 3080521 accccaatgc agtaaatcaa aagttccata tgtgataact tttttcattt aaagaaacgc 3080581 tccttcctaa tgttaaacac tattaaaaac actactgacg ttagcgatta aattctaaaa 3080641 acctgtttgt attccttata tcgacatatt tctcgtatgt cttcactgat cattaattat 3080701 agcataccgc ctaaaaaagg ttaagtactc atgaggagaa aaacattcca aaatatgtaa 3080761 ttacactcag actccattgg caccaaggtc tgttgttcat tcgttcattc aattgtaaaa 3080821 ttggaaacat atttaaattt aatgtaaaga taatgttaat cctttgttga agatttatgt 3080881 taaaatataa ggtagcttga ttttgctttt agaaactctc ggtttttaac tatataaata 3080941 gaatcttaaa ggaaggagga gccagacatg caaacagaga ctattcacaa tattccttat 3081001 gttaacagta acttaacatc atttatcgat tacctagaga aacattatat tgatcaaaag 3081061 attggtgctg tcatttccac agtcaaccct gaaattgcat ttgcagctat taaagatcgg 3081121 gactactttg atgtactatc ttcttcaaac ttcattttgc ctgatgggat cggtgtagtc 3081181 atgatgtcac gtttgactaa caacaggctt cagtcccgaa tcgcaggtta cgatgttttt 3081241 aaagaacttc tgggcgttgc taacaaaaag aaaaaacgca tatttctgta cggtgcgaag 3081301 aaagatgtta taaaaggtgt tgtatccaaa atttcttctg aatacccaaa cattaaaatc 3081361 gcaggttatt cagacggtta tgttcaagat cgcaccctag tggcaaaaca aattgcaaga 3081421 gcaaatcctg acatggtatt cgtagcttta gggtatcctc atcaagagaa attcattcat 3081481 aactacagac acttgttccc taaagccgta tctataggtc taggaggaag ctttgatgta 3081541 tttagcggta atgtcaaacg ggccccttcc tggatgatac gtttaaattt agaatggttc 3081601 taccggttaa tcttgaatcc atggcgatgg aaaagaatgc ttagcatccc aaaatatgct 3081661 ttaacggttt taaaagaaga aaaaaacaaa aaaactttct atccaaagcc tgaaaaagat 3081721 catacaaaac agatttaaaa acaaaacttt caaataaatg gatgataaaa atgaaaataa 3081781 gatcactact ggcgaattgc tatttgtatt ttttatcagc aatcgccttt tttctgcaat 3081841 gggtgaaacc tgaaagcaaa gtgaccctcc tgatctcatt cgaagcaaac gcaaaagcga 3081901 ttcttgagga atatgaacaa ggacaatact cttataaact taacatcctg tatacccagc 3081961 aggcctctgc tattgccgag agcttcccga atgtagatgc atatttatta caagaaaaaa 3082021 accctatcca tctcattaaa gctgtatacc taatgtttaa cagtaaagtg atcataacag 3082081 ataattactt tctattaaca agtgtgttaa ataagcggaa gcaaacgaaa tgtatccaag 3082141 tatggcacgc aaatggctca ctcaaaaaat ttggtttgga agacattaca aacatgcaac 3082201 ggacgaaaac tgatattaaa aggttccaaa aagtatacag ttcgtatgat tatttaactg 3082261 ttggctcaga agagatggca aatatcttca agaaatcatt tggaataaag gataaccaat 3082321 tattaaaaat aggtgtacct ttaacagacc cttattaccg agaaaacaag aaaaaaattt 3082381 cagatactct aaacatacaa agaaaaaaaa taatcctcta tgcaccgacg tttagagatt 3082441 ataatatgca atcaattcaa ttgcctttta cagaagaaca attaattcat cagttaaaag 3082501 aagaatatgt tttatttgtt aagctgcatc ccgccattca gaacaatatt gatattaaat 3082561 attccagtga ttatattaaa gatgtttcta actatgcctt gtttgatcta ctcatggctg 3082621 cagacatatt aatcactgac tattcttctg ttccctttga attttcgatt ttaaataaac 3082681 ccattctttt ttatacttac gatttaaaac tttatcaaca gaagcgggga ttggttgata 3082741 attatctttc cataatacct ggaagagcct gctatgacag tgaatcatta ataaatgaaa 3082801 ttcaaacccc atttaattat tccaaaataa aagttttttc cgatagatgg aataagtatt 3082861 ctgatgggaa ttcaagccaa aatttattga atttcatcga aaatttaata agctaaatga 3082921 tgacacttgt tcaaaacaga acaagtgttc ttttttctat tgaataccga acgtatgttt 3082981 gctttaatgt aattagttgc ttatggcagc aaataataat agaggtggta aatttatgag 3083041 aaaaaaagaa ctgtttgatt tcaccaacat cacgccaaaa ttatttactg aactacgtgt 3083101 agcagacaaa accgtacttc aatcattcaa tttcgatgag aaaaaccacc aaatttatac 3083161 aacccaagtc gcaagtggat taggaaaaga caacacccaa agctatcgca taactcgtct 3083221 atctcttgaa ggtttacaat tagacagcat gctgttgaaa catggaggtc atggtacaaa 3083281 tattggaatt gaaaaccgta atggcaccat ttatatttgg tctctatacg ataaaccaaa 3083341 cgaaacagat aaaagtgaat tagtttgttt cccatataaa gcaggcgcga ctttagatga 3083401 aaattctaaa gaacttcagc gattctcgaa tatgcctttc gatcataggg ttacacctgc 3083461 tcttgatatg aagaatagac agttggcaat tagacaatac gatacaaaaa ataataataa 3083521 taaacagtgg gtgacaatct ttaacctgga cgatgcaata gcaaataaaa acaatcctct 3083581 ttatactatt aacattcctg acgaacttca ttatttacaa ggtttctttt tagatgacgg 3083641 ttatttatat tggtatacag gagatacaaa cagcaaaagc tatccgaatc tcataactgt 3083701 atttgattcc gataataaaa tagtgctgca aaaagaaatt actgttggca aagacttgtc 3083761 caccagatat gagaataact tccgtgaacc ggaagggatc tgtatgtaca ccaatcctga 3083821 aactggggca aaatcattaa tggtgggaat tacaagtgga aaagaaggaa atcgtataag 3083881 cagaatttat gcataccatt cttatgaaaa cttcatgaat catgtaccta tgcttcgatc 3083941 ccctttatta aaaaccgtgg ggcaccaaga tacacctcca gaaagatttc aaccatttat 3084001 tcaaaccttc attttagagt ataatgctca aaacaaaaaa tggatggttc cgacttcagg 3084061 ttatttacca tcttacacat caaatttagt ccgaaatatt actatcaatg cagatggaaa 3084121 cttgcaagtc acattaaatg aacgctatat tagtttactg catcaatcga tagaaggaga 3084181 tttccgctta aaacaaaagg atatccgaat gggatcctgg tattttgccg gcggagaaaa 3084241 atcaaatgtg cttgaaatag gttttatgaa agggagtaca aaaatcagac ccgatgatgc 3084301 agccatctca aatgcttcaa gaatgagtat ttttatgatt gttgcggaca agattgaggt 3084361 gtgataatca aataggctgt agctatttaa tagctacagc ctatttgcaa ctttctaagt 3084421 tttttatcga tattccggaa catcggccta ctttatagac cagcttcttt cggggcaata 3084481 tgcataaaga aaagactcca gagattggag tctttttctt ttattgcacc cgtatacttc 3084541 ctgcgtattt atccttccaa tatgtgctcg tgttcatatt ggtaatggtc acgccgtttg 3084601 ataatgtgac atgaacaact tgtccgtttc cgatatagat ggagggattt aagcttgttg 3084661 attgaaagaa cacaatgtct cccggcttca ggtccgcctt ctcaatctta gttccggcat 3084721 tgtactggct tgttgcgtat cgaggcaggg aaataccggc tgctttctgg tatacatatt 3084781 ggacaaatcc agctgtatca aatcccgtct caggtgttac tccgccctgt ttgtaaggca 3084841 cttctccgac ataaagcgtc gcttcggaaa caatcggatt ttctttcggg attgtcaggt 3084901 tgtcaaatcg gcgaataccc gtcatcttcg atttccagta atcctctgac aaataggaaa 3084961 tggttacttt ttctgaccgg cttgcctgaa tgaacctgcc tgcgcccgca taaatgcctg 3085021 catgtgaaat tcccgtttta tacgtattgc tgaaatagac gacatcacca ggctttatgt 3085081 tctgaggggc taccttctcg cccactgccc actgctgttc ggctgatcgc ggtagataaa 3085141 tgccgagtgc ctgttgaaac acatattgca caagccccga gcaatcaaag ccctctgacg 3085201 gcgtgcttcc gccaaacaca tatgggacac cgatatattt ttcggcctcc tgaacgacag 3085261 gaacatcagc cgttgccgga tcggcagcga ttcgtctcgc cccgatataa gttccgctcc 3085321 aatagctgct ttttttgtaa ttggtgatga taaccccttt tgactgtgta ctgtgaacca 3085381 tttggccgtc tccgatataa agggcgtcat gtgtcggaac agtgccggtg cttccctctt 3085441 tcttgaaaaa caaaatatca cccggcttca ggttttccgg ttttacagct gttccgattt 3085501 tatactggtc gtttacagat ctcggcagat gaatatcagc cttactgaac acatattgta 3085561 tcaatcctga tggatcgaaa ccctctttcg gcgtttcccc gccatattta tactgatatc 3085621 caagcaggtt ttttgcttcg ctgacaatca attctgatga tgtatcagct tccgcaatct 3085681 ccgcttttgt cataattgga accaaaaaac aaatgataac cgccacaagc aaaaacttct 3085741 tccagtttgc cagtgtgttc acttttatta tctcctcctc tttttgcagt tttaacatcg 3085801 gtattttttt gaatatgtta agagactttt taatattttt acagaatgaa tatgctgggc 3085861 aaataaaaag agagtgtctc atcagacact ctcttttttg aattatttat tggcgtttac 3085921 cggttcttcc tgctgctgga ttttattcat ttccatatca atcttctgtt tttcctgatc 3085981 tgtcagctga tcattgaatt taaaagctga cataaacatg aacacgatgg ctacggcaac 3086041 aaacggccag atggctttga caaatttcat ctttatcact ccgattattt agattttagt 3086101 ttgtcactat gatcaatatc aaacgtcagt tttccgtctt ctactttcca agcgaaatta 3086161 gagtctttcg tcagttcgcg aataatggtt ttctgtttaa ggctgtcttt tttcacaggc 3086221 gcaggtgtcg cttcatggat atcgatcggt gtcacttcaa agcgtcctgt tccatttttc 3086281 ttcaggtgat actgaaccag tgcactgtct cttgttctcg tccagccttg gtcaaagaca 3086341 aagttgccga ggctgtagaa aatgacggtt ccgttatata cttcaatcgg ttctaagacg 3086401 tgcgggtgat ggccgacgat gatgtcagct cccgcatcag acatggctct tgcaagctgg 3086461 cgctggcggt catttggatc attgtcatac tcttgtcccc agtgtgactg cacaacaaca 3086521 atgtccgcat gttttttcgc ttctgaaatc atagggatga agatttcagg atctgcgggc 3086581 agcacgcccg gcgtattctt tttagccgcg aaacctttcc cggacacatc ggtaaagcca 3086641 agcgtcgcaa tcgttacccc gttgactttc tggtacgaaa ttttcttttt cgcatcactt 3086701 aagctgtatc ccgctccaac gatatcaaga ttttgcttcg caaattctcc aagcgtatct 3086761 ttcatgccct gaacgccgta atccattgcg tggttgttgg cgctgttgag aaccgtgaaa 3086821 ttcatatcct tcaagacttt cactgattcc ttattcgtct gcagatgaat ctctttatct 3086881 gcttgtttat aattcttttg ataggttacc gggttttcaa agtttcctgc tacataatcc 3086941 gaggctctaa agatcggttc aacatattga aaaatactgt ctgccccttt ttgctccgtt 3087001 actttttcaa catagcgtcc catcataata tcgcctacaa atgaggctga gagtacgtcg 3087061 tcagaatacg ttttgacctt cggcgtttcc gcttttcccg cccacatgaa agcgaacata 3087121 aggacaaaaa cgatcggaat ggcaataaat acgtgcttat tggttttctt tttttgctgt 3087181 tttgtcagct ttagcagctt ttcatgaaag ctcagttctt ttttcatcgt ttgacacacc 3087241 ttacattaaa ttaagtagta aacaaacatg atagcaaagg tcgctccgct caatagcagc 3087301 gtgcttccga acgtaatggt taaaccttgt ttctgaatgg tattggcaat taaacctggc 3087361 acgatgatgc cgattcctcg aaattctgcg atttcaaatg gtacaatcgg gtatagaaaa 3087421 tcaaacgcga tttttaggac gatccctgtt atcagcatgg cagcgaattt tctgcgtccg 3087481 tacaaaatca taaatttgga taaaccgtat ttcacaatga catacgtgag caagctcact 3087541 agcaaaacaa gtaaaataaa gaccggctga ttaaacacaa gtcctaaata tcccggtaca 3087601 acaagtcctg ccggcacgat ccctgttttt tccgcaaaaa ttaaactgag tagtacacct 3087661 aaaattagtg cgatgtataa atctgatccg aacatgtctg catttccccc tagcttacga 3087721 gctgctttac cttgtattcg tggatttttt caattaaagg ctctgcggca ccatgaatat 3087781 tgccgacgcc atatatgaca cggttgtgca ttcttttctt taacaattcc ataatttcat 3087841 ctgttgactt atactctaga tcatgcagtt tgtctgcagg aattttgcct tcttcgtagg 3087901 cttttacgat cggttctgtt gtttcaccga ttaagatcag ttcacttgct tcaatataag 3087961 gcaatacgtc atttgcgaat tgctgtgtcc gatcgacacg gtctgcgcgg cagttcatga 3088021 tgatgatcgg atcatcggtc gggtaaccga tttcttttac acgtttccat atattcaaag 3088081 tagaagaagc gtcgtttgcg gcaaacccat taacaaagtg cccaggctcg ctcggactga 3088141 tcagcggaag aattctcatt gctcccggat ctggcggcgc attcagcatt cccttaaatg 3088201 ctgtttcttc gtcaatgccg agtgcttgag ccacacccag cgccagagaa gcgttatcag 3088261 ggaataccat gtattcaaat ttacgtaaat actcatctgt aatttttgag ttatcagcaa 3088321 tgatgacttt tgtgtttcgt tcttttgctt tttgtttaaa gaactcggta tattcactat 3088381 ctgtaatgac aagatggcca ttataaggaa ttgtagcagt aaacgcttct gcaatttcat 3088441 caagcgtcgg ccccatgaca tccatatggt cttccaaaac attcacaatg acgccgatat 3088501 tggcctgcag aagttcttcc tgaaagatga tttgataatc tgggttaaca gccatgcatt 3088561 cactgacaat cgcgttagcc cctctttcta ctgtttctct catgacttct ttttgctctc 3088621 cgatattcgg cccctgaggt ttccgtttaa tcggcttttc ctccggtgtg tcccagtaaa 3088681 tcattcttgc atctgttcct gttgtttttc caacagtctt gtaaccggct tctattaata 3088741 ttccggttgt cagccttgtc acagtcgatt ttccgcggat gccgttaata ttcacccgaa 3088801 cagggagggc atcaatgttt ttctgatgtc gtcgtttttc taatattccg atgaccagta 3088861 tgacagcaca ggctataatg agtaaccaca ttgcttttcg acatctcctt ctatattgtt 3088921 gtaaattcat tcatcagtat atagaatcac tatgaattct caatcggcat tatgtaacat 3088981 aatcttccct aatcgactaa gccaaacttc tcttttgaaa gagattttat acctacaaac 3089041 tgttttctat ttttggaaaa cagcaggact tataccttat cactttttaa aaaaatcaaa 3089101 gagaatgcgc tttcattttt ctcctgatat ccttctggac gtatagtcac accctgctgt 3089161 ttgtatttaa tatgcatttc aaatcaatct ttttttcagc ctttgttatc aagcatttcc 3089221 tgctatcatg cgtgtttccg gttcttatga acacaaaata attttatcct gtttcttaag 3089281 gacaaggtca taatgtcatc ctttctgcat ggaataagca atatgaggcc cattccaaaa 3089341 tgactaagga ggttcgagat gaaaacgcta aacatacgag tccgaattct ctaacataat 3089401 taaacatttt ctgggatgat agtcttttct gtttctcccc atttacaggt ctaaacgcat 3089461 gactttgaaa caattttaat aaaacttaat atttgttcaa gaaatcttca tccatatttg 3089521 tgaagacttt gtcaaaaaaa gagtgaaaac cttaaatttt tcaattatat atacaattta 3089581 caattagatt tcttttgata tttttattgc taacttcgga ttgttcatga taatctatct 3089641 atgtaaacgg ttacataaac aaggaggagc tgttttggct acaattaaag atgtcgccgg 3089701 agcggcgggc gtttcagttg cgacggtttc ccgcaacctg aatgataacg gctatgtaca 3089761 cgaagaaacg cgaacgcgtg tcatagcggc gatggcgaag ctgaactatt acccgaatga 3089821 agtcgccaga tctctatata aaagagaatc ccgactgatc ggacttttgc tcccggatat 3089881 cacaaaccct ttcttccccc agcttgcccg cggtgcggag gatgaattga accgggaagg 3089941 ctatcgcctt attttcggca acagtgacga ggaattgaaa aaagaacttg aataccttca 3090001 aacctttaag caaaatcatg tcgcaggcat tattgccgca acgaattacc cggatctcga 3090061 ggaatacagc ggcatgaatt atccagttgt ttttctggac agaacgcttg aaggggctcc 3090121 ttctgtgtcc agtgacggct atacaggagt aaagttagcc gcccaggcta tcattcacgg 3090181 aaaaagccag cgcattacgc tcttgagagg acccgctcac ctgccgaccg ctcaagaccg 3090241 atttaacggc gctttggaaa tcttaaagca ggctgaagtt gattttcagg tcattgagac 3090301 agcttcattt tcaattaaag atgcacaatc gatggcgaag gagctgtttg cctcttatcc 3090361 agcgacagat ggtgtgatcg cgagtaatga tattcaagcc gctgccgttt tacatgaagc 3090421 attgcggcgc ggaaaaaacg tgccggagga cattcaaatt atcggctatg atgacattcc 3090481 gcaaagcgga cttctgttcc cgccactttc tacaattaaa cagcccgcat atgatatggg 3090541 gaaagaagct gccaaactgc ttttgggtat cattaaaaaa cagccgctgg cagaaacggc 3090601 aattcaaatg cctgtcacct atataggaag aaagacgaca agaaaggaag attaagatgc 3090661 gtaatatttg tgtgattggt agctgttcta tggatttagt ggtcacctcg gacaaacgcc 3090721 caaaagccgg tgaaacggtt cttggcacgt catttcagac tgtgccgggc ggcaaaggag 3090781 caaatcaggc cgttgccgca gccagacttg gggcgcaagt gtttatggtc ggcaaagttg 3090841 gagacgatca ttatggaaca gctattttga ataatctcaa agctaacggc gttcgcactg 3090901 attatatgga accggttaca catacggaaa gcggaaccgc tcatattgtg cttgctgaag 3090961 gcgacaacag cattgtcgtt gtcaaaggcg cgaacgatga catcacccca gcgtatgcgt 3091021 taaacgcgct cgaacagatt gaaaaggtcg atatggtgct gattcagcag gaaatcccag 3091081 aagaaacggt tgatgaggtg tgcaaatact gccattctca cgatatcccg atcatactaa 3091141 acccagcacc ggcccgcccg ctcaagcagg aaacaattga tcacgctacc tatctgacgc 3091201 cgaatgaaca cgaggcttcg attttattcc ctgagcttac catttccgaa gctctggcgc 3091261 tttatccggc aaagctcttt attacggaag gaaaacaagg cgtccgctat tcggctggca 3091321 gcaaagaggt gctcatcccg tccttccctg tagaacccgt tgatacaacc ggagccggtg 3091381 atacgtttaa cgcagcattt gccgtggccc tggctgaggg aaaagacatt gaagccgcat 3091441 tgcggtttgc caatcgtgcc gcttcccttt ctgtctgctc cttcggtgcc caaggcggaa 3091501 tgccgacaag aaatgaagta gaggagctgc tgtcatgaaa aaacacggta tactgaacag 3091561 ccatcttgcc aagattttag ccgaccttgg ccacactgat aaaattgtca tcgcggatgc 3091621 cggactgccg gttcctgacg gcgttttgaa aattgatctt tcactgaagc cgggccttcc 3091681 ggctttccaa gatacagcgg cagtactggc tgaggaaatg gcggtcgaaa aagtcattgc 3091741 tgcagctgaa ataaaagcat ccaatcagga gaatgcgaaa tttctagaaa atcttttctc 3091801 tgaacaagag attgaatacc tttctcacga ggagtttaag ctgctgacaa aagatgcaaa 3091861 ggcagtcata agaacaggag aattcacacc atatgccaac tgcatcctgc aggcaggtgt 3091921 acttttctag aaaggaagat gaaacatgca gattgaaatg aaagacattc ataaaacatt 3091981 cggaaaaaat caggtgctgt caggcgtttc ctttcagctc atgcctggcg aggttcacgc 3092041 attaatggga gaaaacggcg ccggcaagtc cacgcttatg aacattttga caggcctgca 3092101 caaagcagat aaaggtcaaa tcagcataaa cggaaacgaa acgtattttt ccaatccgaa 3092161 agaagcggaa cagcatggaa tagcctttat ccatcaggaa ttgaatatct ggccggaaat 3092221 gaccgttctt gagaatctat ttatcggtaa agagatatcc tccaagctgg gcgttttaca 3092281 aacaagaaaa atgaaagcgc tagcaaaaga gcaatttgac aaactttccg tctctctttc 3092341 tcttgatcaa gaagccggcg aatgttccgt cggacagcag caaatgatcg aaattgcaaa 3092401 agcgcttatg acaaatgccg aggtaatcat tatggatgaa ccgaccgcag cgttgactga 3092461 acgtgaaatc agcaagctct ttgaggtcat tacagcgtta aaaaagaacg gcgtctccat 3092521 tgtctatatt tcgcatcgca tggaagaaat ttttgcgatt tgcgacagaa ttaccatcat 3092581 gcgtgacgga aaaacggtag atacaacaaa catctcagaa actgattttg atgaagtcgt 3092641 caaaaaaatg gtcggacggg agctgactga acgatatcca aaacgcactc cttctctcgg 3092701 tgacaaagta ttcgaggtga aaaatgcttc cgtaaaaggg agttttgagg acgtcagctt 3092761 ttatgtgcgt tccggtgaga tcgtcggtgt ttcaggatta atgggagccg gccggacaga 3092821 aatgatgaga gcgctgttcg gcgttgacag gctggacacg ggtgagatat ggatcgctgg 3092881 gaaaaaaacg gctattaaga acccgcagga agccgtgaaa aaaggtctcg gctttattac 3092941 agagaatcgc aaggatgaag ggctcctgct cgacacctcg atccgcgaaa atattgccct 3093001 gcccaatctg tccagcttct caccaaaggg tctcattgat cataagcggg aggctgaatt 3093061 tgtcgatctg ttaatcaagc gcctcactat caaaacagca tcaccggaaa cgcacgcacg 3093121 ccatttatca ggaggaaacc agcaaaaagt ggtgatagcc aagtggatcg gcatcggacc 3093181 gaaagtgctt atcttggatg agccaaccag aggtgtggat gttggcgcca aacgagagat 3093241 ttatacgctg atgaatgagc tgaccgaacg cggtgtcgct atcatcatgg tgtcatcaga 3093301 gcttcctgaa attctgggaa tgagcgatcg gattatcgtt gtccatgaag gcagaatcag 3093361 cggcgaaatc catgcgcgag aagcaacaca agaacgaatt atgacacttg ccacgggagg 3093421 gcggtaatat gaaaacggaa caactgcaaa cagaacaaaa acggattcac ttcgacggag 3093481 tcatgcaaaa actcggcccg tttcttggtt tatttattct cgttatcatt gtatctattt 3093541 taaatcccag ctttcttgaa ccgctgaata ttttaaacct gcttcgccag gtcgccatta 3093601 acggattaat cgcgttcggg atgacctttg ttattttgac aggcggcatt gatctttctg 3093661 ttggcgctat tcttgccctg tccagtgctt tagttgcggg gatgattgtg tccggtgtcg 3093721 atccggttct cgcgatcatc cttggctgta tcattggtgc cgtactaggc atgatcaacg 3093781 gattattgat tactaaagga aaaatggcgc cctttatcgc cacgcttgcg accatgactg 3093841 tgtttcgcgg actgacgcta gtgtatacag atggaaatcc gattaccgga cttggcacaa 3093901 actacggttt tcagatgttc ggacgcggtt actttttagg cattcctgta ccggcaatta 3093961 cgatggttct tgcctttgtc atcctttggg tgcttcttca taaaacacca ttcggacgcc 3094021 gaacgtacgc tatcggcggc aacgaaaaag ccgcgctcat ttcaggcatc aaagtgacgc 3094081 gcgtgaaagt gatgatctat tctttagccg ggcttttatc cgctcttgca ggtgccatat 3094141 tgacttcccg cctgcattcg gcccagccga ctgcgggaga atcgtacgaa cttgatgcta 3094201 tcgcggcagt cgtcttagga gggacaagtc tttccggcgg ccgaggacgc attgtcggca 3094261 cgttaatcgg ggtgctgatc atcggcacac ttaataacgg acttaatctg cttggcgtct 3094321 catcatttta tcagctggtt gtcaaaggga ttgttatctt aattgcggta ttgttagacc 3094381 gcaagaagtc agcttaggag ggttttacat gaaaaaggct gtatccgtca ttttaacgtt 3094441 atcattattt ttgttaaccg cctgttcgct tgagcctccc caatgggcaa agccatcaaa 3094501 ctcggggaac aaaaaggaat tcaccattgg cttgtccgtc tcaacgctta ataatccttt 3094561 ttttgtctca ttaaaaaagg gtatcgaaaa agaagctaaa aaacggggaa tgaaagtcat 3094621 cattgttgat gcacaaaatg attcatcgaa acagacgagt gacgtggaag atttaattca 3094681 gcaaggtgtt gatgcattat taatcaaccc gactgattct tcggcgatct caacggcagt 3094741 agaatctgca aacgcagtcg gtgtgcccgt cgtaacaatc gatcgatctg cggaacaagg 3094801 aaaagttgaa accctcgttg cttccgataa tgtaaaaggc ggtgaaatgg ccgcggcgtt 3094861 tattgccgac aaacttggaa aaggagcaaa ggtggcagag cttgaaggcg tccccggcgc 3094921 atctgccaca cgggaacgcg gctcaggatt ccataacatc gcagaccaaa agctccaagt 3094981 tgtcacaaaa caatcagctg actttgaccg cacgaaaggc ctgactgtca tggaaaacct 3095041 gctgcaggga catcctgata tccaagctgt ttttgctcac aacgatgaaa tggcgctcgg 3095101 tgctctcgag gcaattaaca gctcggggaa agacatattg gtgatcggtt ttgacggcaa 3095161 taaagatgcg ctcgcttcca ttaaagacag aaagctgtca gccaccgtcg ctcagcagcc 3095221 tgaattaatc ggtaaattgg ctacagaagc agcagatgat attttgcacg ggaaaaaagt 3095281 gcaaaaaaca atatccgcgc ctctcaaact agaaacacaa aaataattgt ctgatgttta 3095341 ggaacctgcg ataacgtgaa tagagatata gaatgaatta tttctcttac gtgaggagag 3095401 gaacggcatg aacaaaccaa caaaactatt ttcaacatta gcacttgcgg ctggaatgac 3095461 tgcggcggct gctggcggcg ctggcacgat ccatgctcaa cagccagaaa caacggtaag 3095521 cattgatgat ttatacagtt atccgattga ttcttatttg gtatcagcag aggctctaaa 3095581 tgtcagaacg aagccttccg catcaagcca gaaagccgat acgctgcact taggagatag 3095641 cctaaagctg atttccttct caaatgctga ctgggcaaag gttaagtata aaaatggaaa 3095701 aacaggattt gtatccactc attacattgt taaagcagcg acaacggtaa aaaccaaaac 3095761 aaaaacaaaa gtgtatacat ccgctgacgg aaagagcatt aagactcttc cagcagacac 3095821 aagcgtttct tttttaggct ggagtaaaac gaataaaggc ggttttgatt ttgattgggt 3095881 attcgttgat tacggcggta cgacaggtta tatgaaaaca aaggatttac acatgacaaa 3095941 ataactgaga gggattccgc ataaatgcgg aatccctttt attatgaatt gatttgtcac 3096001 attcccaaga tatttctcag gaaatattgt cgtatgctgt gtcgaaacct tacatgatca 3096061 tcgacatttt tgttcacgct aaaaagcgga ggtgtaaata tggatcaatt tgaagcagca 3096121 tatgaatcgt ataaagcccg gcaaacaact gccgatcaag aaaatgttcc atctggaaaa 3096181 gaagaaatta ttgcggttag aagaaatgag gaagacaata ttatcgcagt gaaaaccaat 3096241 acaggaagag agctcgacta ccctactgcg ctgtcagaag caaaatcagg aaaactcgct 3096301 catgttgatg tcttccataa atacgggcgt gacattttgc gaagtgaacc ggacggcatc 3096361 aaggaaaata acctgtctga gctgccggat ttttaaacaa atacagccct gccgtatgtt 3096421 ggacagggct gtattttaaa caaaaggctg ctggatgtat tcggctaacc gttttgcact 3096481 gtgagaaata tcctctgcag ctgcataatt cacgccatag aacacatatg gaggcagata 3096541 cttcatgccg atcagattac tcgtggcctg aaatggtttc aatagctcac tgatcgagta 3096601 atgatttgct ccgcccgctt gatatttttc cgcttcgctc cctgttgata cagccagcat 3096661 cagctccttg ccatgcaagg catttccttc tgaaccaaaa gcccagccat aagtcagcac 3096721 aagatcctgc cattttttca agagcggcgg agagctgtac caatatagcg ggaattgaaa 3096781 gacaatccga tcgtattcct cgcacagctg ctgttccttc gcaacatcta tcgcttcatc 3096841 cgggtattcc ttataaagat cccgtactgt gatattgtca tgtttactca attcctcagc 3096901 ccacgcctta ttaacaactg aggtctccat atgaggatgc actgccaaaa ccaatatttt 3096961 catcagacca cacctttact gttttgatgt tattttatct aaaatcagga aaagagccaa 3097021 ataaaaagaa agccctgcta aaaggggctt tctttttttc ttttattcag ggcttccttc 3097081 agttgtttcg atatctttcg caaaatcagg gttatccaga ttcgcattaa agaaatccgc 3097141 tgtgttcgga agtctgagat tcatgttcat tttttgagaa atcgtaaccg tgcaatcctc 3097201 aagcacatag tcaaaaacgt gtccgcctga attgcgtcct tcgtcaatga agtgcaggtg 3097261 atagccagaa acggcgattc cgtttgcata agctggtgtc aagaaaccta caatcgttcc 3097321 tctcacgttg tcgaagttga aaatcggctg tgttttgacc gcttcaacca ttggcacgta 3097381 aggtttttct tgaagttcta ctgttcttgt ctgcaccttt ttaaacaatc cgtcaatgcg 3097441 aattgcataa aataagtttc tgcttggcag catgctgttg atctcttttt caaagtcttc 3097501 gcgtgtcatt ttcgcatcaa ttttgtgcgt catgtccggt gtaaagaacg taaatgaaca 3097561 gaacggtgaa cggtctccat tttggaccgg tgtcgcggtt ccgtctgagc gaagacggta 3097621 aaattcgccg tcaaacccaa tcagctctcc gtcaagcttg ttaaaggttc cgataccgaa 3097681 gtctccatat ttcggaatct ctgacagttc aaaatctccg tcatatactc cgtctaatag 3097741 agaagtcatt gttgatactt gataaatctg gctcacaggc tgatcttttt gaccacggct 3097801 gagcacttga atgttgcttt ctcgtttcat atttcccttc actcctttta tttagtgctg 3097861 ttcataaaac agtgtcgtga tgcgcagagt gctagagagc tttcgttttc atgagttccc 3097921 cgaattcttt cggaagcttg tcacttgcta aattaatgtt atcactgtag tcaaccggga 3097981 catcgatgat gacaggacct tcagcgttca tgccttgacg cagaacatct gccagctggt 3098041 ctggtgattc tacgcgcaag ccagttgctc cgaagctttc cgcatatttc acgatatcga 3098101 tatttccgaa atcgaccgca gatgtacggt tatatttttt caattgctgg aatgcaacca 3098161 tgtcatatgt gctgtcgttc catacaatgt gtacaattgg tgcttttagt cgaactgctg 3098221 tctctaattc cattgctgag aataagaaac cgccgtcacc agagacagaa accacttttt 3098281 ctcccggttt caccaatgaa gcgccgattg cccaaggaag cgcaacgccg agtgtttgca 3098341 taccgttact gatcattaat gttaacggct cgtagctgcg gaaataacgt gacatccaaa 3098401 tggcgtgcga accgatatcg caagttactg taacatgatc atcgactgca ttacgcaact 3098461 ctttaacgat ttcaagaggg tgcgctctgt ctgatttcca atctgcaggc acctgctcac 3098521 cttcatgcat atattgtttt aaatcagaaa ggattttctg ctcacgctct gcaaattcca 3098581 ctttcacagc atcgtgttcg atatgattga tcgtggacgg aatgtcaccg atcaattcaa 3098641 gatcaggctg gtaagcatga tcaatgtcag cgataatctc gtctaaatgg ataattgtcc 3098701 ggtctccatt gatattccag aatttcggat catattcaat cgggtcatag ccgatcgtca 3098761 gaacaacatc tgcctgctct agcagtaaat cgccaggctg gttgcggaac aaaccgatac 3098821 ggccaaaata ttgatcctct aaatctctag aaagggtacc ggcagcttga tatgtttcaa 3098881 caaatggaag ctgaaccttt ttcaaaagct tgcgaaccgc tttaattgct tccggtcttc 3098941 cgcctttcat gccgaccaaa acgacaggaa gttttgctgt ttggattttt gctatggccg 3099001 cactgattgc atcatctgct gcaggaccga gttttggcgc tgcaacagca cgcacgtttt 3099061 tcgtatttgt gacttcattc acaacatctt gcggaaagct cacaaaagcg gccccagcct 3099121 gccctgctga cgctatccta aatgcatttg taacagcttc cggtatattt tttacatctt 3099181 gaacttctac actgtatttt gtaatcggct ggaatagcgc cgcattatcc aaagattgat 3099241 gtgtccgttt taaacgatct gcacggatca cgtttccagc aagcgcaacg acagggtctc 3099301 cttcagtgtt cgctgtcagc aggcctgttg ccaagttaga ggcacccggt cctgatgtga 3099361 ctaacacgac tcccggtttt ccagttaaac ggccgactgc ttgggccatg aatgctgcgt 3099421 tttgttcgtg ccgggcaacg ataatttcag gtcctttatc ttgtaaagcg tcaaataccg 3099481 catcaatttt tgcacctgga atgccaaata catgtgtgac accttgctcc actaagcaat 3099541 caacaacaag ctccgcccct ctgtttttca caagggattt ttgttctttt gttgcttttg 3099601 tcaacaccct cactccttat tatgcatttt aaacgtaaaa ttttaaatat cttgtgataa 3099661 gtttcactat acactctttg gaaattgacc tccaatatcg attcgcctta tgattaatat 3099721 gtaatacgaa ttattaacct atggaaagga atgcatattg aatggagctt cgccatcttc 3099781 aatactttat cgcagtagcc gaagagcttc atttcggaaa ggctgcccgg cggctgaaca 3099841 tgacgcagcc tcctctcagc cagcagatca aacagctgga ggaagaagtc ggagttacgc 3099901 ttctgaaaag gacaaaacga tttgtcgagc ttaccgcagc aggagaaatc tttttaaatc 3099961 attgccgcat ggcattgatg caaatcggac aaggaattga actggcacag cggacggccc 3100021 gcggcgagca aggccttctc gtaatcggtt ttgtcggatc agctacatat gaatttctgc 3100081 cgccgattgt ccgggaatat cgtaaaaaat tcccatctgt gaaaatagaa ctgcgtgaaa 3100141 tatcctcgtc taggcagcag gaggagctac taaagggcaa cattgatatt ggtatacttc 3100201 atcctccctt acagcataca gctttacata tcgaaaccgc ccaaagcagc ccttgtgttt 3100261 tagctttgcc taagcaacac ccattgactt ctaaggaatc aattacgatt gaggatttaa 3100321 gagatgaacc aattattact gttgctaaag aagcatggcc tactctatac atggatttta 3100381 ttcagttctg tgaacaagcg ggcttcagac ccaacattgt ccaggaagcc acagaatatc 3100441 aaatggtgat tggtttagtc agtgccggaa ttggtatgac atttgttcct tcctcggcca 3100501 aaaaattatt taatttggat gttacttatc gaaaaatgga ccaaatacag cttaatgcag 3100561 aatgggttat cgcttaccgc aaagacaatc ataatccgct tataaagcat tttattcata 3100621 tttcaaattg tcagcagaca agaactaaag agagtgatgc aggtacatga acaatacttg 3100681 caatctcttt tttcttttgg gattcttatg gaatttttat taatttaata taatcgctta 3100741 gtacaacttt atatcagtat acgtatacat acagtacaaa tagttggcaa ggacatcagt 3100801 aagcgcagga cattagtttg attttaaaaa tgaaagatag agaggtgaag taaattattg 3100861 agttcaccgg catattcaca ttgctcgctt ttttcgtaac aatgattttt attttctgga 3100921 gaccaaaagg actaaatgaa gctatccccg ccacatttgg cgctttaatg gttttattgt 3100981 gcggaagtgt gtcattggca gacttagggg aaatcggaac aaaagtcacg ggtgcatcgg 3101041 ttacaatcct tgccactatg attatggcca ttgcactaga aagctttggt ttcttttatt 3101101 gggtggctgc aaaactgctc caacaatcca agggttcagg catcaagctt ttttggctaa 3101161 ccaatttgct ctgctttctc atgaccattt tccttaataa tgatgggagc attttgatca 3101221 caactccaat ccttttgctt gtactaaaat atttaggttt aaaaaaacat caaaaagccc 3101281 catatttatt aagcggtgtt ttaatagcca cagcctctag cgcaccgatt ggcgtaagta 3101341 atattgttaa tttaatttct ctcaaaatca ttggaatgga tctatatctt cacaccgcca 3101401 tgatgtttgt ccctagtatg atgggactca tttttatgac ttgtctactg tttatgttct 3101461 tttataaacg tcttcccaaa agcctgccag atataccggg ccattttcag tctctgcggc 3101521 atagaaggta ccatcctctt cattcgccat cagctccttt accagaacga aatcaaacaa 3101581 aaatcatgtt gtttgtgctt gcatttgttt ttctcgtcag aatgagtcta tttgcagcat 3101641 catataccgg tatttctgtt cctctagtcg ctgtcatcgg atcttttatc ctgttgagct 3101701 ggagatggat ttatttcaaa acctccccaa gagacttgtt atataaatcg ccttggcaca 3101761 tttttatatt cgcttttact atgtatgtct taatttatgg tctgcataat attggattca 3101821 cagagttact tgtgagttat tttgaacctg tggtttctgg aagcctcgcc catgcaactt 3101881 tcgcatcagg tatctctact tcagtttttt ctaatctctt taacaaccat ccagcgttaa 3101941 tgatcagtac ttttacctta actgaaatga ccctgaatcc ttcaacaaca aaaatcatct 3102001 acttggcaaa tattatcggc agtgatatcg gttcattatt attacctatg ggaaccttag 3102061 caacgcttat ttggatgcat atattaaaac agcatgatga aagtatttca tggggcgaat 3102121 atataaaaac gaccattatc atcattccgc tgactgttct ttttacgtta acatgtttat 3102181 atttttggat cagttggtta tttctttagc acagtatgaa acgaaaaact gccttctgct 3102241 tttcaagagg gcagttttgt atacactagg gaagatgcat tgtctttaga tgatttaact 3102301 tccaaatgac tggctctcca cttgcgttaa taagctcaat gatattatta gagacaccct 3102361 ttaatagtcc gactttttct ggcacctctc ccatatcaaa tatgaccaat tcaccaatat 3102421 tttttttgat ctgctcctca aaattacgca caagaggaac tttggaaggc acgaccggca 3102481 attgtgagtt gtcaagagta tacggtgttt gttcagttga ataaggggta aaccatttta 3102541 aatgatgcat agatataaaa agtattttaa atacgggtga gaaaaataca atataatcgt 3102601 ttaaaacatt tgtaacatat ccatggatcg atcgaccccc agttacataa acttcaataa 3102661 actggccttt gaccttgttt aatgtatttc tatatgaaaa agcttgagtt tctgcctcta 3102721 tcattggatc ttccggattg atcaaaaatg gcttctcagt actggtcact attttcgcct 3102781 tgtttatttg atgaagatgc aacaagggaa tataaagata attgcagcca tcaaaaataa 3102841 caaaaatatc ctgtccgata tctatgaggg tgccgacaaa ccttgtatct cctgaaatga 3102901 caacctcaac atctgtgtta aggaattgat tcaaaccttt cacgattctc ctcctttaac 3102961 tgaaaaaggg catcacttta tctgatgctc ctccattatc tattaaaatt tacgtttcca 3103021 gtgatagtct atcgttctga caatcgtttc atagctataa tcttcctttt gttttcctga 3103081 actttttatt gaacttgaat agcctggtga tcttgatgat tgataatctg aagatcttgg 3103141 tgatcgttta gatgattttg atgattgata atctgaagat tttaatgatc gtttagatga 3103201 ttttgaagaa ctttttgaac gtgacgaacg gccagatttg gatgattgat aatccgaaga 3103261 ttttagtgat cgtttagatg attttgaaga actttttgaa cgtgacgaac gaccagattt 3103321 ggatgattga tcatctgaag attttagtga tcgtttagat gattttgatg agctatatga 3103381 ttttgaagaa atgaacgaat tgctgtcctt atcattattg tcttcctggt tttgttcatt 3103441 tttttgatcc tcttttttgt acgacccttt tggacctaag ctgatgcttt ttatgtgaaa 3103501 aggatagatg cgaagcacct cttgattttt cactatagta taatggccgt cggcattatc 3103561 tacaaggata ccctcaatgg cttccggacc tccacgatta attgaaaccc atttatgagt 3103621 cagactctta aaaacctcgc ttaaatcatc agcttccaaa actccaactg gcgtctgctc 3103681 ttctattttc aaatcaggct cgtgtttact tatacttttg atgtgatgga tattaaaata 3103741 cactacccca tcctcatttg tgtttaacgc agcgtaatca tctcccagcc agaccaatct 3103801 tcctttttta gattccggac ccccttggtt aaattgaact gattggttta ttaaatgtcc 3103861 gattaagcta tgaaaatcat cagcatcgag catttcctca gtctcaattg ttgtggtgct 3103921 attattggta tcctcagtaa tacttttcac atgctccaac tgataataaa ttattttttt 3103981 ttcagcttgt aaagctatat aatctgattt tacagctgtt aattttcctt ttttagattc 3104041 cggacctcca cgatatacag taacaatttt atctttcatt gagtgcaaaa agttataata 3104101 cgatatttca ttatttgaat gatatttcat tctcctcttg ctcattcaaa ttcctcctag 3104161 tcacttatac atagatgata aacatactgc atatatacgt gtcacattta tttgttgaac 3104221 taattcaata gcctaattgt cgctttttcc gcgaataccc attttcacgc attcataaaa 3104281 tacttaaatg atctttgagg tattgtgaac ggtttttaat atactcgcag atcacatccg 3104341 gctcacggtc aaaacgctca atatcattct ttttatacgg gtccatgagg acaaacggcc 3104401 taatccgttc atacatcgcc atgattttcg gttccatata ttctattgta aaaagagatt 3104461 ggagcgtttt ttctaacagg cgcttgtagg acttgcgaaa ctcggattca tccaatatcc 3104521 gggcggttag tgtattaaat ccttgaattc ttacataatc ggcagccatc cgctctccat 3104581 ggatatccct gccccaagtc gcatcataat cccaaggaat cacctcaaat aatccggttt 3104641 ccccgcttct gtataatgcg tagttgtgga caaacccgtc atagttcgag gtgaatacaa 3104701 taccagcaag ccagcgcaaa tacttatcga catccacgtg ttttgtcact tctgacttaa 3104761 actgagcttt agggaccgta ttaattttaa aaatcatatc ttgtaaataa aaatcatctt 3104821 cctcagtccc tgttttcttt tcatatccaa gctccagcga tgttttcgtt tccctttcta 3104881 aatcgctcat cagagaaaag ttggcatcat catccaccgc ataaaaaatc gcgccatcag 3104941 ccagcttcct tttcgccaaa taatattcat ctacggattc aagttcaaga taaacccctt 3105001 cattcttccc attcatcttt acaaacgcaa actctgcctt tggagacagt gtccctagct 3105061 ccgagaaaaa atccagagac aatttgtttc tcatcaagga agggtcttta tactccgcat 3105121 ttaagtgaat ctctcgcgcg ccgcggaatg ttttcggctg ataaaaggaa atatggtatg 3105181 acttcttttt gaagtctctg atatgtgatc cccgataagc gatatcaata tccagccttt 3105241 tttgatttac cttcatcaca gctggcaccg gatcatcgtc ccatatatcc ttttttaatt 3105301 cacgcaagtc ttttggatga acaaacagct gataaagcgg taaattggat tgattcttca 3105361 tccataatcc tccttacaaa ttttaggctt ttatttttat aagatctcag cggaacactt 3105421 atacactttt taaaaccgcg cgtactatga gggtagtaag gatcttcatc cttaacatat 3105481 ttttaaaagg aggatttcaa attgggccac tattcccatt ctgacatcga agaagcggtg 3105541 aaatccgcaa aaaaagaagg tttaaaggat tatttatacc aagagcctca tggaaaaaaa 3105601 cgcagtcata aaaagtcgca ccgcactcac aaaaaatctc gcagccataa aaaatcatac 3105661 tgctctcaca aaaaatctcg cagtcacaaa aaatcattct gttctcacaa aaaatctcgc 3105721 agccacaaaa aatcatactg ctctcacaag aaatctcgca gccacaaaaa atcgtaccgt 3105781 tctcacaaaa aatctcgcag ctataaaaaa tcttaccgtt cttacaaaaa atctcgtagc 3105841 tataaaaaat cttgccgttc ttacaaaaaa tctcgcagct acaaaaagtc ttactgttct 3105901 cacaagaaaa aatctcgcag ctataagaag tcatgccgca cacacaaaaa atcttatcgt 3105961 tcccataaga aatactacaa aaaaccgcac caccactgcg acgactacaa aagacacgat 3106021 gattatgaca gcaaaaaaga atactggaaa gacggcaatt gctgggtagt caaaaagaaa 3106081 tacaaataat ctaagttttc attgtttcaa taggctgccg gcggaggtac ggaagcctat 3106141 ttttttattt gccctgtatt agatatatgt catgacataa catatgcaac ccgcatcatt 3106201 tggtttcctt taaaccattt cgttataatc aaggtatcct aacgataaag gcggttgttg 3106261 ctatgtacat atttcaagct gatcagctta gtgccaaaga cacatacaag ctattgtcag 3106321 gtaccgttat tccccgcccc attgcatttg tgacaacact ttcttcagga ggagcggtaa 3106381 atgccgcgcc tttcagtttt tataacgtcg tcagctcaga tcctccgctt ctcagtattt 3106441 ctgttaacag gacggaagga cgccaaaaag atacagcacg aaacgcagtg gagaacggag 3106501 aatttgtcgt tcatgtcagt gatgaagcca tcattgaaga tatcaatgaa acagctgcaa 3106561 gcttaaggcc ggatgaaagc gagcttacac gcacctcgct tcatcctgtt gaaagcaaag 3106621 ctgtttcagt tcccggcatt aaggaagccc gcgttcgctt tgagtgcaaa ttagagcggc 3106681 atattacctt tgacaatgat caaggcatca ctacagcaga tctgctcatc ggaagagttg 3106741 tctgcttcca cctagatgaa aaggtgtatg atgcagaaaa gggatatatt ttaacggatg 3106801 aattaaagcc tgcctcacga ttggcgggaa atcactatgc caagctgggg gaagaattca 3106861 cactgattcg tcccagctga agagaaggac tatttaaata gaagaaacta gtcaaaaaga 3106921 ccttatgatt acaaaatatc gcctgtaaat aactgaaaaa atatcaaaaa aaagaacacc 3106981 cagagcaagc tcggggtgtt cttttatgaa acgtttttcc tttttcttcg tataaaggta 3107041 gattaggagg aattggaatg acaaactttt ggattttaat gctgatcgct attaccatca 3107101 gtctcgcctc tcaatttttt ataaagaaaa aatacggtat tgataaatcc ggctggcgat 3107161 ataagcatgt cagcaataca cacaaatgga tcgaaatcac tttacttatt ttgtttgtgt 3107221 tttcactctc cttttttcca gttgaatatt tgcttctttt attttttatt gtgattgact 3107281 caatacgtat ttttatggag tggcattata gacctgaaga taaacagtat atgtaccaca 3107341 ttgtagaggt ctcccttatg tttatgcttt tgatttatgt ttgtacccta tagttattta 3107401 aatccccaca gccgctccgt ctccccgagg atcggctccg ccttggagaa agccttcttc 3107461 atcaactttg attgcagccg cttgtcccat cagcggatca tagtcaccga caacctccac 3107521 gagatgcccg ctgtctttca gtttttggat tgttttgtct gtgaatctgc cctcgactct 3107581 gagaccttcg tattcctctc cccacgttct gccccatacc cagcgcggtt cgctgattgc 3107641 ctgctgtgga tgcattccgt agtccagcat tcgggtaatg atggccgtct gggtctgcgg 3107701 ctggccttcg ccgccttgtg tgccgtacag aatttttggc tttccgcctt tacagaccat 3107761 agccggcatc aacgtatgga aggtgcgctt tctcggttca agcgtgttga catgattttc 3107821 atccagtgag aaaaacgatc cgcggttttg cagtaatatg cctgtatcac cggcagtgac 3107881 tgccgagcca aattcaaagt acaggctttg aatgaatgac actgcgttgc catccgcatc 3107941 gattacggcc gcatatgccg tatcacttcc caccggcctg ctttctgccg gtattgcgag 3108001 atagccgatt tcttctgcca attgttttgc ataacgtttg tccaaaagcc tttcaagcgg 3108061 aatgtctgca aacgccggat cagtcaggac ggcatcccga tctagaaaac tctttttcaa 3108121 tgcctccaca agcacgtgat aatactcaaa tgaaccgtgt tcgatttggg tgaaatcata 3108181 gttttccaaa atgttcagtg ttaataaacc ggtaaatccc tgagaattcg gcggcgcctg 3108241 atacacactg tatcctcgat aatcacttga tacaggcgct gcccactcac cccgatgcgc 3108301 tttaaaatca tcgattgtca tgtaactgcc gttattctgt aaatgtgaga caatccgctg 3108361 agcgagatct ccttcataaa atgcgcttct tcctttttca gcaatcaagt tcagactgtc 3108421 tgcaagctct ttttgcacaa accgctctcc cgggacaggt gctttgcccc ttctcgtgaa 3108481 gatgtcagcc gtgtaaggcg tggaagccag cagttcaata ttcttttctg tgtgacgaca 3108541 ctgatcagct gatacaggaa acccattttg ggcataatcg cgtgcgggct ccaatacatc 3108601 tgcaagagac agacgcccgt actccttcag gaccgcatcc cagctatcaa ccattcccgg 3108661 cacggtaata gcactgtcaa ttccccgcag cggaatcgcg ctttttccct tatatacatc 3108721 tctcgttacg ttttttcctg aacggccgct gccattgtag acttttactg cctttgtttc 3108781 ctggtgaaag gtcagccaaa aggaatcccc gccaagtccg gtcatatgcg ggtacacaac 3108841 cgcaagacaa gcactcaccg caacagcggc gtcaaacgcg ttgcctccct tatccagtat 3108901 gcggtttccg gcttgagaag cgagataatg cggactgacg accatttgct ttgtaccgat 3108961 gacagatttg ttcatcacaa gtcccctttt ttaagaaatt ttcttcagta tagggagcct 3109021 gatttttcac atctactgat ccggcagaaa aactgacgaa ctttcttctt ttcgcaaata 3109081 ataagatatt ttcgcattca tttcgaaaac aaatgaaaaa ttattatttc tatacgtaac 3109141 ttttatgata aaatgattgc taaaaggcta cgaaagcagg tggagcaatt gagtcatgaa 3109201 tatcaaatcc ccaaccttgt acttgatgag actgataaac aaattctcac gattttgcat 3109261 gaagaaggca gaatttctta tacggatctt ggcaaaagag tcgatttgtc acgggtcgcc 3109321 gttcaggccc gtatcaacca attaattgaa gccggtgtta ttgaaaaatt caccgctgtc 3109381 atcaatcccg ctaaaatcgg catccatgtt tccgtgtttt tcaatgtcga ggtagaaccg 3109441 caatttttag aagaggtcgc tcttaagctt gaggaagagc ctgcggtcac cagcctttat 3109501 cacatgacag gcccgagcaa gctgcatatg catgggatct ttaccaacga tcaagaaatg 3109561 gaagaattct taacaaaacg gctgtatcca ttgcgaggcg tcgtcagtgt tgattgccag 3109621 atgctgatca aacgatacaa aagccgtatg ggaatgaagc tgtaaaggag agaaacaaat 3109681 gaaaaaccat ccttatcggg atatgacggc cgcaatggtt cgcaccggca tattagggtt 3109741 cggcggcgga ccttccgtga ttccgctgat ccgccatgaa gcggtcaata aatataaatg 3109801 gattgacgat gatgaattcg gagaaatatt agcaatcgct aatgcgcttc ccggaccgat 3109861 tgccaccaaa atggctgctt atctgggctt taagctaaaa ggcacattag gtgcaattgt 3109921 ggcgatcctc gcccacattc tgcctacatg tcttgcgatg gtgggcttgt ttgcggctgt 3109981 aaatgtgtta agccattcag caattgttgc aggtatgatt ggtgccgtca cgccggtaat 3110041 tgcggtcatg ctcggaatca tggcgtacga gtttggccaa aaagcgctta aaggtttcgg 3110101 ctgggttacc ggcatcctgt tttttatcat cgcttttatc ggcctgcaaa ctttacagat 3110161 taatcccggc ctggtcatta tcattttctt agcttacggg gcgtttcatt ttaaactgaa 3110221 agacaaaatc acaaataaac attcaaaaga taaaggaatg tcagcctcat gatatcgatc 3110281 tatttattta tggcgttttt tatcgcaaac ctactgggat atggcggcgg acctgcgtct 3110341 atcccgctaa tgtttgaaga agtcgtaaac agatacagct ggctctcaaa cgatcaattc 3110401 tcaaatatgc tcgcacttgc gaacgcattg ccgggcccga tcgccacgaa aatcgctgcg 3110461 tatgtcggct acagcgcagg cgggtggccc ggcttcctaa ttgccctgat cgcaaccgtc 3110521 gtaccgtcgg cgctcgcatt gatcgtcctg ctgcgcatca tccagcgctt ccgccaatca 3110581 cctgtcatca aaggcatgac gctgtccgtc cagcctgtca tcgcggtcat gatgctcatt 3110641 cttacctggc aaatcggcgc agacggcatc aaagcgatcg gctgggtcca atcgatcgtg 3110701 attacgggaa tttcgctcct tgccatgaca aaattcaaaa tgcatccggc atttttgatt 3110761 attgcggcgt ttttatatgg gggccttgtg atcccttatt tatagaaaaa agcacctgga 3110821 caggtgcttt tttattttag cccagaaatg ccgtttgata tgacagctgt ttcttctcct 3110881 gcgtcactct tgatcatgtg cttgacttgc agcgtggttc ctgccattct cacagattgc 3110941 ttcaactggg acgaattggt ttcaacttgt atccaaacag gaggctggac cttccaaaat 3111001 aaatagagtg caagaatcag caagccagca atgaccgaca gcaaaaactt catatcgcat 3111061 cgcttctttt cagtaagcgg ctcgcagcgg acagcgcctg atgatcacga agaatatcgc 3111121 ctggacgatt gccttctccc agcacatagc ctttaaagga cattcccata aaatgaaaaa 3111181 tatgttcgaa ttgctgaatc agcggcagcc cttttatttt tggattgtct ccgcccactg 3111241 ctattacata tgcctgtttc actgacattt gctgtttaaa atcaggaaat ctcggatctc 3111301 tcaacgtctg tgaccagcga tcaataaaca gctttaatgt ccctgacatg ccaaaccaat 3111361 aaattggggt ggcgaatata agaatatggc actgcaatat ccgttcaatg atagaatcgt 3111421 agtcatcttg aacaggacga aagccgcctt gggcgtgacg cagatcttca attggttgaa 3111481 ttggatattt ctgcaaataa atgtgctccg catcgaatcc ttgaacagcc ttctccgcaa 3111541 gaacatccgt atttccgcca gaccgagttc cgccgttaat aaccgcaatt ttcatgatgc 3111601 atctgctcct ttgtttacga atgattttct tcatcatata atggattcat caatcaatac 3111661 agatgattat ttcgattaat ccaatcgcta aaaccgattt agaaaggaag agaacaagtg 3111721 gaattgaagc agctgatcac ctttattacg gcggctgaac atgtaaactt caccctaacc 3111781 gccaaaatgc ttaattatgc acaatcaagc gttacctctc agatcaaatc acttgaagaa 3111841 gaaatcggaa cgcctttatt tgaacggctc ggcaagcggc ttatcttgac agaagcagga 3111901 aaaacgttca aatcttatgc acagaagatc attgcgttaa cagaagaagc gaaaatggcc 3111961 acaaatcaag taagagaaac aaccggaacc ttaaaaatcg gggcgacgga aagccagtgc 3112021 acataccgcc tgccccctat cataaaagaa tttaaacagg cttttcccca agtaaagctc 3112081 atattcaaac catatatctc caatgaacaa gcgaaagaac agctcttaca gggccagctt 3112141 gatatcacct tcatcttgga tgtaaaccgg atggaagacg cactgcacgt tgaatctttg 3112201 attcaggatg agatcaaaat ggtggctgct aatgaccatc cttttcctgc ggatttacca 3112261 gtaacattga aggatcttca aaacgaaact cttctgctga cagaggacgg ctgctcgtac 3112321 cgcacgctct ttgagaacaa tttgcatgac tccggtatct atcctaacaa attggaattc 3112381 gtcagcatag aagccatcaa acaatgcgtg atggccggac ttgggattgg aatcttgcct 3112441 gaaatgacag taaaagatga tattgcagca ggccggatga aagaactcaa ttggcagagc 3112501 gattgccccg ttttcactca attagcatgg cataaggaca agtggatgtc tgcgccatta 3112561 aaggctttta tcgatttgac acggaaaaca ttcaaataaa acctctccac aaggacgaca 3112621 aggtttttga gaccagggca cacacataca aaaaaaacac ttgatgactt agagccccaa 3112681 gtgttacacg tgatttttct gataaaacgt tcgcaaaaca tgcgtctcaa ggtcagccag 3112741 gcggacaggg atcggcagcc tgctttcttg attgatcaag ctcatcgtga tctgatagct 3112801 gctgtctaaa tcaatataat taccgcaaga caagaaaata ggcttcacgt cccgccgcgt 3112861 tcgcagcgcc cgtccatata cctcgccgtc aatgataata tcggtgtatg cgcctacttc 3112921 aatttcaggc gtcacgaaat cgcagccttt gattttgaga taggttttcg ctatcccaat 3112981 cgtcggcttg cccagaaaaa aagccgcatg ggtggcaacg cccatatgat tgtaatgcag 3113041 atatccgttg ccatcaaaca agaagacatc cggctccgtc tccagctttt tcgccgcctc 3113101 gatgatcaag ggcagctcgc gaaacgcaag aaaaccggaa acatacggca cgctgattct 3113161 ccccatgctg tgcacttttt caatgacttc ttttgtatca gcgtcaatta cgataataca 3113221 gcacactccg tatggttctc catcctgctc ccaataggcc aggtcgacgc ctgcgcaggt 3113281 gttgatggag tctggatgga tcgtggggga taggttgata cgatttttaa ggttaaattg 3113341 cacttgtaaa aagtcttgtt cctttttcat atcaaattta tgcacatcaa ataccttcat 3113401 aacgattgct cactctcgac ctaaattaat gtgagtctct cttctcgatt ctagtatttc 3113461 aaaatgagga ctatctgtat ctatctcgta cttatttaat agattgcctt cttcatccca 3113521 attcttttca gaaattagta tggaatgctc atactgttgc tcactttttt tcctgccatt 3113581 ttcaaaccaa attatgctta taccgtgcaa ttgcccatat cggtattctt tttcactttt 3113641 tttattcccg ttttcataaa attcacatgt taaaccatgg gccagaccat tcttatattt 3113701 agtaaaatag atgatttgac catttggata taattcgtaa gccagccctg taaacggctg 3113761 gccattttcg tcttcaggat tatctaaaat ctcatcactt accgaagaga accataaatc 3113821 ctcaaagtcc actccctttt cttttatact cttcatatca tattcatttt ccatacttta 3113881 aagcctccgg tatataattt gtattttgag ttatatattc acaatgtgga catctaggca 3113941 ttgggacacc ttctggcatc tttttattta ttttcctagc acttactaca tataccatta 3114001 aatcttttaa atccgcatca ggtctttgaa gtaacgcttc atttagagca ttaacttcgg 3114061 catgagaacc cgcccctgac gtctttatat aaccttcttt aagttctgta ggcatattta 3114121 caattctatc atgaataagt ggatgtagta ccttaggtgg cttcccatct atattgttta 3114181 ttccaaaata ataattgcct gtttttttgt ccaatacacc agctaccgca gggcctcttt 3114241 gttttttagt tagaccagaa gatttaattc tactaagttc gtttagtact tctgccctta 3114301 gatttattcg atggtgaaga tcttctttag acaatacacc atgcttattt cttaaatatt 3114361 gaagcctagt ttgtttttct tcagtagtct tagcaatatt gctaataagg ctttcattac 3114421 tcactttatt gacatatgga gcattttttt ggtacaaccg atcaaagtag tgtgccaatc 3114481 ctgctccacc aataatagta atagcttcca gcgccccttg cttccgcttc tcctcagaca 3114541 ctttgtttcc gaacatatcc cggcctgtga cagcttctga gaatccgttt gacgcaacaa 3114601 ggccgtatgc gcccatttct gtcattttga gaatgtctaa ggatttgcct gttttgtagg 3114661 cgtctaatgc gtgttcagca gcgatagctg cttttccggt tttgtagatg gcttttccgc 3114721 ctttgaaggc ccggcctgcc cagccgacga ctggtatgaa tccggcagcg gccatagctc 3114781 ctgctgtcac acgctccgcg gtggagagtt tttctccggt aaccggatca acgccttcgg 3114841 ttgctctttt ataatcataa tagccagtga cttctccagt aaagttgcaa actccatccc 3114901 atgttttttc gtaccacggt ttgtttgctt cttcctcggc tttttcctgg agccgtcttg 3114961 cttctgcttg ctgggttttt gcatcgatat aggttgttcc ttgattttct acttcaatga 3115021 cgcttttgta gacttcattg ctgtggaagg cttttttgtc atagtacata ggggatgcgc 3115081 tcttcccatt gctggtggcc tgcatgagaa cagaatattt ggtgagcact gcgttgtcca 3115141 gagattctaa attttgatat tcagtggtca gggattcatc aagcttatcg acagctgtga 3115201 ttgtatcacg tctgattttt tgggcatcgc ccatcttatc tgcatagtcg tcaagcgtgt 3115261 acatgtcgag atcaataata tcgctgatgc ctgacaaaat agaatcgatt tcttctttat 3115321 gagcggagac aatctctgag gctttcaggt ctccattggg cagctcatga tccaaaaaag 3115381 aagtttccac atatgaatca ttcagttctt gatctttaat atctcctgaa atgccgttta 3115441 aaaacgcaat ttgagcagag acaagcgtca gccagctgtc tacgatttct gcctgtccct 3115501 gaaaaaaatc tttaatattg tccgcgccat ttcctttaaa attatcgcct aaatcggcaa 3115561 ctccctgaaa cgcttttttc agcgtattca gctgctcttc aagcgtctca tattgctttt 3115621 ttctgctctt cgcttcttcg attaaagatt ttgattcaaa tactttactc atcgcactgc 3115681 cctttctgtt ctattttacc gctatcgcct cgtcctgctc tttgagtgaa tctacgttat 3115741 cctttgtatc ctcgatattt ttctgtaccg cttttttgta atctccgagc atggttttga 3115801 tgttctcctc acgctcatgg tattttttcg tataatcgag gctgtttttt ccgttggatc 3115861 ctgcggcgcc gattgatacg tcagcaagcg catctttgac agaatctaat gttttgatga 3115921 ctgtgtcgta cttcagctta atttctgaca taaaaaaaga tcaccaccat tttagtttac 3115981 taattgtatt tccgacttct tccgcgaact cttctccctt tttaagaaga tctgctgcac 3116041 catttgctat gaacaattcc gatgcatatt tagctttatc ccattcaaga tcaaaaattt 3116101 tcccgttaat cgaagccata tactcgttat atttatcatt cacaatctta gatgcttccg 3116161 atttcgcctc ttctcttccc ttgtcgaaat catcggcttt tgttcccgtc caatgcttgc 3116221 ccaattccgg tttcacaatt tctttgattt cagtgattgc ctcttcttgc agtgtgtcta 3116281 tgtccttttt tgcttttttc agcttttcga tcttgtcttc cacgtctgaa atttttccgt 3116341 tgagcgaact tttgatatcc gctagcatac tttcataacc catctgaatc acctcttaat 3116401 actcaaaaag tcgtatggag gggctgatga agatagactt ttccatactt tatttccata 3116461 tattatattt taaaatagcc agaaggcggc ttaaataggg taaatggctt aatttaggca 3116521 tataacgctc ttgaaatgta ggtatttgat cttgtttttg ttcgttatac agctaataaa 3116581 agcgttttat aaaatgaaat cacctaatgt catagttata aaggcacttg aaagaggcag 3116641 atgttgttga tctgcctctt tcggcgctga gcttattgtt catgtttatg ttcttcatct 3116701 ggtcggccat gtctgatttt gtcatttggc ttctattatt ccccccttct gaccctttgg 3116761 atcaaaagct tgtattagct gcagtcccag ttgtacagaa cgtttgaaaa gtcttttttc 3116821 cttagatctt caggtgtgat gaaaaaattg gcgatgccga cgtctcccca cattgaatcg 3116881 atatcatcgt ctgaatcaat ttgtaacagc atgatggtgt gttctttata tgcgtattcc 3116941 cggggatcat gctgggtaaa agaagcgtat ccgccaattt tatggccaaa tccgttttca 3117001 gccagttcat tataaatgtc ttcttcatcc tcgccgaact gaccaaagaa ctccattgtt 3117061 tccatgcccg tatactgctc aaattgaaaa tctgtaggca gcacccattc cgaagatttc 3117121 acaggctcga ctgccgcttc tgataaaatc ggaaaatcac attcgcctgt gccaataaat 3117181 gaaaaatcag aaacaagctc gtcatcgttt tctacgatat tttcaaaata gatcactctg 3117241 aaattctttt gttcacatcg atcgtcaaaa ttcaatccat agacgtcatc atgaacagaa 3117301 atgtagaact gcaggatacc tgaagaaggg tagccgtcaa gctggggaat gtgcgagaaa 3117361 ttaatctgcg ccagaagttt catcggctgt ccattttcgt cagtcggata tgtttcatgc 3117421 ttggggaaat agggatcacc ggcaattttg ctgtcatatc gtcctgtttt cccctttctc 3117481 acattcagtt tcacgtattc tttcgctgat ttctccagca agtcgcggta cggtctcatt 3117541 ttttcgggca gatgattcat cagattctct ccttttccgg catctccaag gttttatttt 3117601 ctggttttct tctaatgttt ttcaaacgaa tgtttaaaga agccctactt ctgcataatt 3117661 ttccaaacaa tagttaaata gtagcaaatg tattcagcac cccgcaatag atgaaaaaaa 3117721 gactggtgcg caaccagcct ttctttttca tctattgaat tgcacctgac ggaacaaccg 3117781 ccttccgtcc gacagaataa tactccactc ctgcagccaa agcctcatcc aatgtgtagc 3117841 agtttctgcc gtcaaatatg agcggcgttt ccatcaaatc ctgataagcc gctaacggga 3117901 attgtttaat gtcagcccag tcggttaaaa tcatgacggc gtcagaccct ttgacagctt 3117961 cctcgatcgt ctctttatat tcaacagctt gcgggagaac atgctttgca tggctaactg 3118021 caatgggatc gtaggctctg atacgggcgt cgagcgcagc gagacggtct gcaataacaa 3118081 ttgacggcgc ttctctcata tcgtcggtat tcggtttaaa tgacaggcct aaaagggcaa 3118141 tcgtttttcc cgtcacccca ccgagcctgt tcagcgcttt atcaaccagc atcgcctgct 3118201 gattgttgtt gactttgata acggatttca gcagttcaaa atcatgctcg acattgccgg 3118261 caatttgcac gagggcgttt gtgtcctttg gaaaacaaga gccgccgtag cctatgcccg 3118321 cttttaaaaa ctggctcccg atccgcttat cctgtcccat cccgtatgcg actgcttcaa 3118381 tatcggcgcc gaccttttca catatattcg aaatttcgtt tataaaactg atcttagtgg 3118441 ccagaaaagc atttgaggca tatttgatca tctcggcgct tctgatatcc gtttggtaaa 3118501 tcgggatttg aaacggacgg aagagctcct ccagcgtatt tgctgttttc tcatcggccg 3118561 tcccgatcac gatcctgtca ccatgaaagg tatcatagat cgccgacccc tcacgcaaaa 3118621 attccggatt ggatgcgacc gaaatactga caggctccgc tagatgttca gtaatcagtc 3118681 cattaatcaa atcgtttgtc ccaacgggca ctgtgctttt cgttaccacg actgtatctc 3118741 gtttgacatg ctttgcgatg cgtttggccg catctgtaat ttgctccaga ttggcgtgcc 3118801 cgtcgctttt ctgcggtgtg ccgaccgcta taaaaatgat gtctgcctgt gccaagcctt 3118861 tctcatagct cgtttcaaag ttcagccgtc catcagctgt attttttctc atcagctctt 3118921 caagacctgg ttcaaatatg ggggaaatgc cctttctcat ttcatcaatc ttgtgagcgt 3118981 caatatcaat gcaggttaca tgatgtccaa tctcagaaag agaaacacct gtcacaagac 3119041 cgacatagcc tgttccgatg actgttatat tcattgtttc cctccaacag ttaaattgct 3119101 gctttgcagc ttccgtaata tcgtatgaga acatcctatc atgaatgcga atgatctccc 3119161 gcatagcctg tcgggtacag cctgtacaga tttctgaaat gtgattcaac catacaatac 3119221 actattatat cgctctcaaa aagaaagtgg tgaaatgaga atcggctgtt aaaaaaaacc 3119281 aaacaatttt cttcttttga ccggctgcgg aggctgtctg aagatggtct gattccgcag 3119341 gagaagctct gcattttccg tcagcatata aggaagttcc gagccgaatt ctttctctag 3119401 aacataaaga gcctcttgag tgtgaaaatt tctcgttttc acattatggg catctgaggc 3119461 tacgaaatgg atcaaattgg cttcaaccag ccggagagaa aatgctttca gctgcttgcc 3119521 gaagatcccc gcaagacttc ctgaagtaat ctgagatgct gctccttttt ccacaagatg 3119581 atacagcaag gacgggtttt cgcgaatttc cctgttgcgt tcaggatggg cgataaccgg 3119641 aatatatcct ttcagctgca aatcataaaa aagctgctcc gcatatcggg gaacgtgatc 3119701 aaacggaaac tcaatcaaga tgtattttgt atcattcagc gaaagcagct gacgtttggc 3119761 aaggtcttgt tccacctcgc cgtagattct gatttcctgt cccggaagca catgtaaagg 3119821 aatgtcttct ttgattaaac gtttgtttaa ctgatctgct gcttctctga ctgcggctgg 3119881 ctcgttttta tacacaccgt tgttatgatg aggtgtcgca atgatcgtcc ggattccctg 3119941 acgaacagct gctcttgcca tttctatgct gtcggccgaa tcacctgccc cgtcatccat 3120001 tgcgggaaga atgtgacagt gaatatcgat catgtcctag cccccttttt tcgcaaaaat 3120061 aaataacggg cacgatgcac gttatttatt tttgcatgaa attgtccttg gttccgtaat 3120121 atccgtattc agagtgcttc gaaagctttt tgccgttcat aatcgcccca aggagcttgc 3120181 ttttgcacgt tgcaagcgcc tctttcgctt ttgcggcttg ttctttttct gttttcccgc 3120241 ttgaaataac cagaacagaa ccgtctgcca cgttgcctaa aatctgtgca tctgctacgg 3120301 caagaatagg cggcgtatca aaaatgacca tatcatatgc cgcacacgct tcgtatgcaa 3120361 gctccttcat ccacttcgag gagagaagct cggccgggtt tggcgggatc gggccgctcg 3120421 tcagcacgtc aagatgtttt tcattcgatg cttgtacagc ctgctccata gagcttttct 3120481 ttaataaaac agatgttaag ccaaccgtat tttcaagaaa aaaagccgta tgtactgttg 3120541 gttttcgcaa atcagcatca atcaggagca ctttttttcc ctgttgggcg aatacgacag 3120601 ccaggttggc ggccgttgtt gattttcctt cccccggaca agccgatgta atcatgactg 3120661 atttcatttg ccggtccact gaagcaaatt ctatattcgt gcgaatcgtc cgatattgtt 3120721 cagagttcaa ggatttcggc tctgtcattg caatgacatt tctctgcatc cgcgagcctc 3120781 tgttttttct aagcgccaaa atgtccactc cccgtttttt cagattggaa accctgtaag 3120841 gtctttgctg ttttctgctc attcgcaatg gtggaaactg tccctaaaac aggtatgtcc 3120901 agcaaggatt cgagctgctc ttccgatttg atcgtattat ccaaatgctc aagcaggaag 3120961 gccagtccga tgcttcccgc caatccggcc gcaaacgcga tggcaatgtt tagtagcggc 3121021 tttggcgata caggggacgg gtgttctgaa acctcggctt ttgacagaat gctgacattg 3121081 tcaacattca taatggatgt gattttgtct tgaaaaacag atgctatagt attggcaata 3121141 tgagccgctg tttccgcgtt ttcatccctg actgatatgt tgaccacttg ggagtcctgt 3121201 tcgctggata cggtaatttt gtcattcagt tcttgggatg tcatcgacag gcccatttct 3121261 ttaatgactt catctaagat ggcagggctc ttaatgatga cattgtacgt attgattaac 3121321 tgaagattgg tttggacatc gttaaattgg acttcttttc gttcattttt cgattggttg 3121381 accagaatct gagttgaatt ttcatagatg ggtgtaagtg cgaagaaact aatgagtccg 3121441 ccggcagcag tggcagccgc ggttacaatc ataatcaaaa gtatgcgttt tgttaacgtt 3121501 gataatatct cttttaagct tgtagattct cccatgatac ctccaaatct cttataacat 3121561 ccttttccat ctacgattat acaacgttga aaccgcattt ctccagcttt tcacgtgaca 3121621 taattcgaca tttttttaca atgcgttatg ttagtacttt ttatgtaagc gctatattta 3121681 ctgtgttgac agtgctgtct cattttctct tattcgggca gtcacgttct ctcgcataaa 3121741 aaaatcccgc taaaggcgtg cgggattttt atgttgcata tccattttta atatgagaaa 3121801 tcaaattttc aagcatttcc ttcgtcgtca tctcagatga ctgctcacca atttcatgtg 3121861 catgcatcaa aattttcaga aattcttctt gattcaattt cttttcactc atcttttttt 3121921 tcctttcagc ttccattaag ttgaaaacac gattattata tgatgctggt tatcaatttg 3121981 caatctctaa tacatcattc gacacatcct attttttatg tcctttttta ggaaaaactt 3122041 tttaaggccg atgtgttgcg atataataga gaaattggat ctttttatta cgtgactcgg 3122101 ttaggagcga taatcatgct tcagaatatg atttccaaag acgatgtgct ggcatctgct 3122161 gaacagttaa aagaacttct tccttacaat gaggaaaatg ttcagctgat caaaaaagcc 3122221 cttattttat atcggcagga ttcagtctat cgtttacaag cagtgagtcc gacggaagtt 3122281 acggcttacg tgcaggatgt tgtgcctgtg cgggtcacat tgaacttgtt tgtcatagtc 3122341 aaaagcggct gttcatgtcc gtccggaaga atctgccgcc atatgctggc tgtgttttta 3122401 tatgtatatg caatgttcga gcgagtgggt acttttacag agtattggct ggagagggaa 3122461 aagcttgagg aaagcaaaga gctcgtccgc cgccagtttc aggaaaaggt gctgcctaat 3122521 gaagaatcac tttcaagctg gcttgctttt tttgattcag agttttctct ctggcaggca 3122581 cgtacgccag aaggcagcca aaacatgcag ggcctctatt acggctacct gtccgcatta 3122641 aaaaaacatg cgccgaacaa gccggagctg aaaagcctgt atcagattca ttccgcgatt 3122701 gcggtttggc ttcgcatgtt cacattgatt gaagcgggca agctaaaccc cgaacaagat 3122761 ttttattccc tcaatccgta cgttgaacag ctgatggata caatctacag ctctattgat 3122821 aaattaaaaa cgtacgcgct gtcttttgcg cttgatccgt ttttggataa aacaccggat 3122881 gttatccggc atttgctgtt gaaagaagaa attttccaat atgaacgcat ccgcgtcttc 3122941 ggtgaaattt ggagtgcgct gctgtcgcgg ccaaaatggg tggcacgcga acaggagata 3123001 ttgaaaaaag aagcaggacg gcgtttttct cccgaattgc aattcgggcg cctgcatttg 3123061 gaattcctgc aaaaaaatga tgacgttatt tttgaggaag cggatcaatt cccgccggaa 3123121 gcgctccctt atacattcca atggctgagt gaaatgactg ccaagaagga ctggaaacgg 3123181 cttaaaacat ggtaccagca aattgaacca attgcgatgg gttatacgaa gctggataag 3123241 ccgtttaaag agattcgcga tgtgatcggc gagctgttcc ttctgttgaa tgcctatgtg 3123301 cagcaaacca atgatcaagc gctgtttgag cgctttgccg cgggctgtct gccgtatacg 3123361 ttcacagaat acagccatca tttatatgaa aaaaaacgct atgccgagtg gattgaaatt 3123421 catagccttg tcggcttttc catcaatgaa atggataaaa tgatgctcaa ggaaattgca 3123481 gcgagcgacc ctgaggcgct tataccggct taccatagag aagtggcttt tttcattgat 3123541 cagaagaacc gtagctcgta caaggaagcc gcccggtatt tgaaaaaatt gcgcaccctg 3123601 tacaaaaaag cgaaaaagca gaaggtgtgg gagcggtata ttcagctgct gagctcgcat 3123661 tacaagcgcc tgcgtgcgct tcaagaagaa ctgcagaaag gaaagttgat tgatggcgag 3123721 tcttaaagaa attctcatcc acgtcgaaca aatggaagat gggtcattta cgctctcagc 3123781 ctttgatgag aatgagcagc ctcttcccta cagccatatg aaaaagcatt tgttccaatg 3123841 gcatgaatcc tcattttacg gaacctttct agaggatgtc agcttcatcg ggacgactgc 3123901 tgtccttcta tctccatgga tgactgtaga gcttctcggc aaaaactcgt tcaactcatt 3123961 cagctccgtg cagcttacag aagaaacgga gccgctgatc gaggcggcat cgaccatcta 3124021 tgaatttatc gcggacggcg attttatgcc tgactatgac gcatggacaa acggtgtttt 3124081 tcgctggaag gaccgcgata atatactgga aggctttact gcggaatggt tttccgctgc 3124141 cgtacaggat tacatccagt acgacgatga cctgcgggag aaatgggaac atatcaagga 3124201 aaaatcgcct gcggttacga cattccgtgg ccattttctt gatgaagagg attttctgga 3124261 aggcattggc tggattgacg atcaatctcc atttactgtc ggcttgcgct taaatgaacc 3124321 ggactttgac ggagacgaat ggaagatcga gatgttttta cgcgataaaa agagcggtgc 3124381 tgtagaattc tttgacggac tgaagagcct caaaaaatcg tggcaggcgt acagcgataa 3124441 aatcgcgcgt gagcaggacc gctttcacag aacggttccg tggctgtcgt ttgattccgg 3124501 gacaacgctg atctcggagg aagaagcctg gatcttcctg tcagaagcaa gtgagacgct 3124561 tgtcgatatg ggggtagaaa tcctcctgcc gtcctggtgg cagattgtca gagacagcaa 3124621 catgatgctg aaagcaaagg tgtcttcctc cccgcgcggc gagtcatttg tcggcatgaa 3124681 tgcactgctt gatttcaact ggcggtttgc gacaaatgga attgaactga ctgaggctga 3124741 atttaatgag cttgtcgcca gcaacaggcg ccttgttaat atccgcgggc aatgggttaa 3124801 aatcgatccg cagtttatca aacagatgaa acgcctgatg gaaaaagcag aatcagaggg 3124861 actccacatg tctgatattc tggcgcggga gctaatggat cagcaggatg gcggacttga 3124921 ggattcggac ctgattgata catctgcttt tgccggcatt cagtttgatc tgtctaaaca 3124981 gctcaggtca ctgattcgaa agctcactgc cgcggaaaac ctgccggagc acaaagtcag 3125041 tccttctttc aaaggaacgc tccgccctta tcagaaatac ggcatgaact ggctgctgtt 3125101 tctgcgggaa agcggttttg gcgcctgtct ggctgacgat atggggcttg ggaaaacgat 3125161 tcaaatgatc gcctatttcc ttcacgtgaa ggaaagcggc cgacaaaaaa cgcctcattt 3125221 gattattgcg ccgacatccg tacttggcaa ctggcagcgg gagcttcaaa cctttgcccc 3125281 tgatctgtct gtcgcgctcc attatgggcc gcgccggcca aagggtgatg atttcgccgc 3125341 gcattatgaa aacgcagacg tggtgctcac ttcatacggt ctgtcacatg ccgatactga 3125401 agagctttct tctgtgacat ggaacacgat ctgccttgat gaagcgcaaa atattaaaaa 3125461 cgcgcatacg aagcaatcac gcgcaatcag gaagctgaag gggcttcacc atatcgcgct 3125521 gagcggcacg ccgatggaaa accgactgac tgagctgtgg tctatttttg acttcatgaa 3125581 taaaggctac ctcggcagtt tgaccggctt ccataaacgc tatgtgctgc cgatcgaaaa 3125641 agaccgggac gaaaagagaa tcggacagct tcagcaatta atccggccat tccttctccg 3125701 ccggacgaaa cgggatgaag aggtcgcgct taatcttcct gagaagctgg aagaaaaaga 3125761 atttatccct ctgtcagccg agcaggcatc cctttatgag cagctcgtca aagacacttt 3125821 tgaccatatg acatccctga ccggcatgca gcgaaaagcg ctgatcctca gcatgcttgg 3125881 acggctcaag caaatatgcg atcatcccgc gctttattta aaggaagagc aaaccgagct 3125941 gctggccggc agatcagtca agctcgaaaa attgctggaa ctgatgacag cgatccgcgc 3126001 ccaaaacgaa agctgcctga ttttcacgca atacattcag atggggaaca tgatgaagcg 3126061 gctgcttgaa aaaacgttcg gggaacctgt gcaattttta aatgggagtc tctccaagca 3126121 agagcgggat acactcgttg agaaatttca aaggaaagaa tatccgacac tgattctttc 3126181 actcaaagct ggaggcaccg gacttaattt gaccgccgcc aatcacgtca tccattatga 3126241 cagatggtgg aacccggcgg ttgaaaatca agcgactgac cgtgcatacc gcataggcca 3126301 ggagcgcttt gtccacgttc ataaaatgat tacgacagga acaatcgaag aaaaaattga 3126361 tgtcatgctt gaatccaagc aaaccctgaa cgatcaaatt atccaaagtg aaaactggat 3126421 taccgagctt tccacacagg agctcgaaga attgtttaca ttaagcgcta cagcgcaata 3126481 atcatgacta aaaaagctgg ctctaaaaga gccagctttt ttccgttcat agccgtcacg 3126541 ccgaatttcc aaaaaatccg ttacgccggt tatcaacagg gtgcgctttt gtggcagcac 3126601 atatacttac aacaaatgtt tcatcatatg tgcgacaccg tgttcgtcat tggttaaggt 3126661 gacagcatcg gctatcgatt tgatgtcttc ccgggcattg cccatcgcta caccttttcc 3126721 cgcagcctcc agcatcgatt tgtcatttaa actgtcacct acagcagcag tttcctcgag 3126781 cggaatattc agctgttttg caagcctctt cagcgcctgc cccttggaag ctttgcggga 3126841 agaaagctca aagttgtgct cagccgaact gacaagcgtc aaatcttcgg catgctcata 3126901 tcttttccag cctgcctcaa gcttttcttt gaagaaagaa aagccgagaa tattgtaaaa 3126961 atcgattggc tcatcggctt caaacagctc ttgaaaggag ttaatgtaag caaagcccga 3127021 ttggctgtat tgcacctcgg ccgcctgctt aaggacagaa agatccgctt ccggatttgc 3127081 gcttctgaat ctgtcgagct caacatcaag aagttctctg ccgttttgcg gcgtataaat 3127141 cgctgaacct gtgaatacct cataataata gttttccgac tcaagccatg agagaatgtc 3127201 atacgcccgt ttcttatcaa tcgtttcgtg atgataaagc ctgccctcgg gatcgtgaat 3127261 gacggcgccg tttgcactga tgacccatgt tttgatcccc agcggttcaa agattgacat 3127321 gacgtcaaaa tgagcgcgcc cagttgacac caccacttca atgccgtccc gctgcgcctg 3127381 ccgcagtgcg ttttcatttt ccaagcttac ctgatgcttg ctgttgagta aggttccatc 3127441 taagtcaatc gcaattaatt tcacgtttgt cagtcctttc cttcatcctg ctctgtcacg 3127501 agaagctcaa cgccgtttcg gtcaagcaag tcacaaaatg cctgattcgg cagcctgtct 3127561 gtaatcaaga ggtcgatttc attcagctcc gcatactgat aaaaactggt gctgcccagc 3127621 ttagaatggt ctgcaagcgc aattacctgc tttgcctgct gtatcatttt ccgcttcacc 3127681 atgccatcct cttcatgcgc aattgtaatg ccatgttcgg aaatgccgac cacaccaatc 3127741 agcgctttat caacatggta gcttgagagc ttttcaatca cagaggaccc gtacagaaag 3127801 cggtgctcct tttccagctt gcctcccagc agataaattt caattccctc tttatcggac 3127861 agcacatccg caagattaat cgaattggtg attacggtac aatcaaccgc attcaaatgc 3127921 tttgcacatg cctgaacagt tgtagaggcg tctaaaatca cccggtctcc atcatgaata 3127981 agcgatgctg caagcctgcc gatcttattt ttttcctcag acactgtttt caggcggccg 3128041 gaatagcttt gaattttctg atgcacagtc ggtaaaatgg cgccgcctct tgtgcggatg 3128101 atggcattct gttcctcaag tttcacaaga tctcgtcgcg ctgtatccct tgacacttgc 3128161 aggagcgtac agatctgctc cgttgtaatt cggttatgct gttttaaaaa atccaaaatc 3128221 gctactaatc tttcttcttg gtacacgccc tcattccttt tctcagcaat catttataag 3128281 taattataag tttttatttg attttattca acattaataa gtgattttaa gtaaaaatgc 3128341 gtcgagagaa ccaatttttc ctaagtaggc aaaaagaaag aaccagtctg gtcgactggt 3128401 caattttgag gggatgatgc gaagatccgg ataatagtga atggatagat aacgggagga 3128461 gcaggggtgt caatcagcag ctttttcccg gggtttaggg tccataaaac gaacagtgtc 3128521 agccaacact tctgttacat acacgttaac gccttcctcg ttttcatagc ttcttgtctg 3128581 aatccgtccg cttacgccga cgagagaacc tttttggcaa tacaacgccg tgttttcagc 3128641 tgtttttctc caaagtgtgc aattgacgta atcagcttcg atttcacctg aagcattctt 3128701 gaagctgcgg ttcaccgcga gcgtaacatg tgcaactgcc gcaccggcgg aagtgtagcg 3128761 aagatcagga tcttttgtaa gacgtccgac aagcatgacc tgattgaaca tgcgattcct 3128821 cctctccttg cggttgtatg tattgtaaat gatgcaacaa gaaaagaaaa acgcttaaaa 3128881 atggctttca gcctctgttt ttatctttcg ttttcatttt tccttcagct aaaaacatct 3128941 tttgcttttt tcctttgaag aaatatgtac tttttaaaaa acggaaaaag atttgctttg 3129001 tcagccagtt ttgcgtattc atgcgcacat aggaagagcc atcccacgca aaccactgaa 3129061 agctcaattt tttttccggc attgacagct tgattttata ctgctccatg ccatcttgtg 3129121 tttcgtataa aaaacttatt cttccttttt tgttcagatg aacctcaaac acttctttac 3129181 ggcttaacat atatgttact tccttttgaa tcaaatgact ttcagaagga acgccgtcaa 3129241 tataaatttc ttttaaacga aattgattca taccacatct ctccgtaatc catagtcagt 3129301 tacagtataa tgaaaaaata gaaattatta aatgtttcgc tcatacaaaa ttctttagcc 3129361 ccaacattgc aggatttttt cctcgaaaac gtttatgtta taatggaagg caagaaaact 3129421 ttggaagtaa tcggggtgag aagaaatgaa aacctttaaa ctggttgacc tgaatgtgga 3129481 acgagtggac aaggaagaac aatcaattga acagtttccc cttattgacg gactgattat 3129541 aaataaagaa gacggtgaaa atcactggct gattgaggcg cttgtacaga aagaacatct 3129601 gtcttttttt gaacagcttc aaaacagcca atctgaagcc aaagtatttg taacgatcac 3129661 gaaaaaaagc aatcgccccg cccagctgac agcagcagtg aaaaatatcg tcaagctgga 3129721 agaaagcatt caggttttac tctacggaca aatggtcaca agaaaacagc agggcactga 3129781 aaccattctc gagtcccttg taaaagaggg ctatacagga acaaaactca ttgaggcatt 3129841 taagcaaaaa ttataaatat gagggggcat gttccccaaa acagactcag aaccgaagag 3129901 catcacaata gacatttaga atagatatgt tctgcatgaa aaaagctgcc gttttgaacg 3129961 gcagcttttc tcttcgtgct ttcactcttg catatttaat ttgtatggcc aaaagaatca 3130021 accaattccc ctttcacaac gaggcgccct tcggttttga ccgccttgtc acatgtgatt 3130081 aacgtaatct cctttttgtt tgtctcctca actacatctg catccatttc cgatatgatg 3130141 tctttcgatg ttacagaata gatataatcc tttttaaaat ccgtgatgac aatttgggca 3130201 cctgttttta tgttttccag aggtccgaac agaagattct tttgcttcaa atgatggccc 3130261 gccaacggat aatttccctc acccattttt tgatcccggc gcattgttgc cgcccctatc 3130321 aaaagatttt cattggttgt gccttttacg atcggaagct ccagatcgac acttttaatt 3130381 gttatccgcc gccttgattg tgaagtaaaa ataagtatat ttcacgtgct ttcgacgttc 3130441 tccacttgac tggaatgctt taatggcgat cccggcatct gtagcttcag gctttccttc 3130501 agaggaatca gaaatctcaa actctatttt ctcagtgttc agcacataac cggctggcgc 3130561 tttcgtttca acaaaagcgt attgtcccgg tgcaaggcct gaagctgtga cttgatgatg 3130621 ccggatatga ctggtttcga agtctgtatg aaaattcgcg aacgattcag catggttgat 3130681 cttccggttc tgatcattac agctgccatt atcggccatg acaaatacaa ggcttttcat 3130741 gccggagcga atgacatttt gcaaaaaccc tatcattact ctgaatttat ggcgcgtatt 3130801 caaaacctga taatgatgaa acatacagca aatcaagcca caagaatgga aatggcgttt 3130861 ctccagtcgc aaatcaagcc tcattttctt tataatgtat taaacacgat tatttctctc 3130921 actcatttgg atattgaaaa ggcccgggag gtaacagagg aatttaccaa ctatttaaga 3130981 atgagttttg actttcaaaa tacatcagcc atcagttcct tcagacatga gctttcgatt 3131041 atcaattcct atctttctat agaaaagacg cgattcagta atcggcttga ggttcttttc 3131101 gatatagatg aagacattga ctttatcctt ccgcctttaa tgattcagcc cttggtggaa 3131161 aatgccgttc ttcacggtgt cagcaagaaa agaggcggag gatggatcaa actgacagct 3131221 aaaaaacaaa gcaaaaatga gtatcacatc aaagtagagg ataacggtcc cgggataact 3131281 ccggaaaaac aaatagatct cttatcaacg gattttgatc gcagcgtcgg attgaaaaat 3131341 atcaatcagc ggctgaaaca tttttgcgga agcgagttga tgatcagcag cactccggat 3131401 gcaggcacct ctgtctcaat gctcattcat ctcgctgaaa caacaggaag ccctaaagaa 3131461 ctgaaggaca cagaacgaac ctaaacgaaa attgagataa aaaaagacgc cgtttctaac 3131521 ggcatctttt ttattccggc gactttgctt gctgcttcag caggtctctg atttctttca 3131581 gcagctcctc ctgcgcatcc accgcttcct ccgcagcctc ttcttctgct tcttttttgc 3131641 gccttaaccc attcaaagtc cgaatgacga taaaaatgga gaacgatata attaagaagt 3131701 tcacaatcgt ctgtataaag ctgccatatt tcactacagc atcgccaaac gtaaacgaca 3131761 ggcctgaaaa gtcaagccct cccagcagca aaccgaccaa aggcataatg atatcattta 3131821 ctagagatgt gacgatcttt ccgaaagcgc cgcctatcac aacaccaatc gcaaggtcta 3131881 cgatattccc ccgcatggca aaggctttaa attcattcca catacaatca cctgcttttc 3131941 tatatttgta aagaaaaaaa gacaaatgtg ccgctggcca tctgcctttt ttcaattatt 3132001 ctccgagggc aaaagtcagt tctacttcgc aaacgacttc gccatcaact gtggcaacgc 3132061 cttttccgcg cccgattgtg ccgcgggcac gaatgatttc aacctcaagg tgaagctggt 3132121 caccaggctt gacttgtttt ttaaagcggc agttatcaat gcctgcaaaa aaagccagtc 3132181 tgccgcggtt ttcttcttta atcaacatcg caacagctcc gacttgagcg agtgcttcta 3132241 cgattaatac gccgggcata accgggtact gaggaaaatg tccgttaaag aactcttcat 3132301 tagcggttac atttttatag ccttttgccc gtttgccctc ttcaacttcc gtaatccgat 3132361 ccacaagcaa aaacggataa cggtgaggaa taatttcttt aatttgctga gtatcaagca 3132421 ttgtcttgac atctccttca tctgcattag tatgtatagc aatcatcaaa gatccaatct 3132481 gtacatttga aaagtatatt atgaattaat ctctttttca accgcgctaa aatgtaacca 3132541 actgtcaatg agagccgtca aaagttatga tatgataatt atagatttta ccaatagcaa 3132601 agaggtagga aaatgatttc gaagtttatt gaaaaaagaa tgctaaacat gttagacgag 3132661 tggtattccg caatgagcaa acgcaaaatg aatcacgttt gcacactgaa agagaaaatt 3132721 gatcagcacc ttccaaagat caaaaagaac acaaaacttt ggatgcgtta tcaattgttt 3132781 caggcccgcc atcagctgct ttttgaaaac cagaacggac tcgattcatt gttcgatggc 3132841 ctatatggcc tggaagacaa aatggatgat gaattgaaat attatctgta ttttttctct 3132901 gggttatatg agatggtaaa aacagctccg aaacatgcag tacatcattt taaaaaagct 3132961 gaacagtacc tggccgccat tcacaatacg tttgaagccg ctgatttata ttatcaaacc 3133021 gccggcgcct attacttgat gaaatcaccg ccgctttccg tccaatacgt caaaaaagca 3133081 ttacacatct atttgcacca attcggctat atcaaaaagg taatcacctg taaacttttg 3133141 ctcgccgtga attatattga tcaagaacgc tatgaaaaag ctgaacagct tttcaaagaa 3133201 atcattaaga aaacccagca actacatgac gaaaacctgc tatgccacgc ttattataac 3133261 cttggctttt taaaagcgac cgagaaaaaa gaccaggaag cgcttcttta ctttagaaaa 3133321 gtattaaaga atcaagaatt tgaaatgaat tcaccagtct catatcttca ttgtgtgtac 3133381 gagtctgtca gagcgctttt taaaacaggg aacatcacag aagctaaagc cgtccttcaa 3133441 aaaggaaaag aattatctga aaaggtagac attcaaacca tttatttaaa attaaaaacg 3133501 cttgaagccc tctacacatc agccgaagac ccttatgagc agctgctcga atatgtgctt 3133561 gaattagaaa aaatcgaggc gtgggtggat ttagaagtgc tgttagaaga tattacggaa 3133621 tactacaaaa aaaaggacga tttcgaaaaa gccgcttttt ttatcatgcg cggctgattg 3133681 aaaaacgccc attttcttat tatctgactg aattgattaa accgagcatt tgatctccca 3133741 ttgtgatcgt tctgctgttc agctgatatg aacgctggga cgtgatcaaa tctgtcattt 3133801 gttctgaaat atcgacattg gacatctcaa gtgagccctg ctgcatgccg atgttttgtc 3133861 tattagcgcc gttcagctct tcaaaagctg ccgcattatc aatagagaaa aggttattcc 3133921 cttcggattt cagctcttga gggttattca cttggacaac gccaagatta aaccgctgaa 3133981 ccgcgtttcc gtcagatgcg gttaaggtgc cgttcttatt aatggtgata ttcttcattg 3134041 agctgtcgat gttcactgta ttgccgttct catcaagtac gggataccca tttccagtga 3134101 cgagctgcag ctggttggca ttcgcagcgg acggcgttac atacagcgcc ccgtccctcg 3134161 tatactggcg gtttccattt acatttacct gaagatactg gtatggagac gtaaatgcga 3134221 tatccagatc gcgatcggtc ttctgaatgc ttccttgatc agagactagg cgtgaactca 3134281 tcatcgctcc gacgccaagg cgcaagccgg gcggcgtttt tcgggctttt gccacttcct 3134341 cgtttttttc atcaacctga tcgaattgct gtctgacaag ctcagaaaaa ttcgtatctt 3134401 ttgccttata gccggttgtg ttgctgtttg aaaggttgct gctgattgtg tcaatctgct 3134461 gctgcagctg gtttaaggtt gttgatgccg ttagcattga cctgagcata gttgatgtcc 3134521 cccgtttttt tcttccgttt tcttaaattt ttccaatttc atttgctgct ttatccatac 3134581 ttttatcgta agcctgaata accttctgat tcgcctcaaa cgatctgtac gcttcagtca 3134641 tttctgtata ggcgcttgtc acatccacgt ttgaaagctc tgagacgcct tgttttaatg 3134701 aataggctac ctgattattt ccggctgcgc ttggcagatc attaccgtcc gccgtgctgt 3134761 acaaatcatt tccgtcccgt ttgagattgc ggacatcttc cgccattctg acatcaatct 3134821 ggccggctgt gcgtccgttc gttgtcacag taccgttttc agacacagtg aaattctcat 3134881 tatcaacagt gattggctgg cgatccgtcg ataaaatagg gcgtccgttg atcgtcagct 3134941 gattgttctc atttagtgaa aatgtgctgc tttttgaata acggattcca tccgctgttt 3135001 gaaccggata aaaaagagca gctttttcat tggtttccgc actcatcgga acttgatttt 3135061 cgatcaatgc aatgtctgta ggctggtctg tggacttcag gcttccctgt gtaaagagag 3135121 gcttgagctc ctgcatatat actccggtat tcacggaacc gatttccgtc cttgatgtcc 3135181 cggccggaga ttttgattct attctgctga gcagcatctc agggaacgcg cgcatagagc 3135241 cttgatcagc tttatatcct gatgtatttg cgttagcaat attatttgaa agcatttccg 3135301 ttcttcgctg ctgggcaatc attgcggatg ttgctgtata taatcctttt aacaaatttc 3135361 ccacctctaa aaatggcatt ttttccagtt gtcatatagg aacgttcgtt ctataataaa 3135421 aactcagtat tttatcctat tatcgtcatt taacatcttt tcgtgaaggc tttttcataa 3135481 aaaaacctca ttctttttca gaatgaggtt tgtgaaatca gcttagtttg cgtttaggaa 3135541 gcttgtccat attatcaagc atgacacctg tgccgatggc tacgcaatcc ataggatttt 3135601 cagcaacgag gaccggtacc ttcagctctt cagcaagcag ctggtcaagg ccgtttaaga 3135661 gcgcgcctcc gccggtaata ataacgccgc ggtcaataat atcagcagaa agttcaggcg 3135721 gtgttctttc gagcacttgt tttgcagcct gaacaataac agcgacagat tcacgaaggg 3135781 cttcttcaac ttctttactg tttactgtaa ttgttcttgg aagaccggaa accatgtccc 3135841 gtccgcgaat ggaaatttcc tcgtgacgtg cgtctgggaa aacagttgcg actttaatct 3135901 taatatcctc cgcagtacgt tcgccgatca gcagcttgta ctcgcgtttg atataattta 3135961 agatttccat gtcaaacttg tccccagcca ttttaataga agaggaggtg acaatatcgc 3136021 ccattgaaat aaccgcgata tccgtcgtcc cgcctccgat gtctacaacc atgttaccgc 3136081 ttggctggaa tatttccata cccgcgccga tagcggcaac tttaggttct tcttcaaggt 3136141 acacatgttt cccgccgctt ttttctgcag cttctttaat tgctttttgc tcaacggatg 3136201 taatattcgt cgggcagcaa atgagcatgc gcggctttga gaacaggcct tttacattca 3136261 gcttgttaat aaaatgtttc agcattgctt ctgttacttc aaagtcagca ataactccgt 3136321 ctttcagcgg gcgaatcgca acaatattcc caggtgtacg tccaaccatt cgtcttgcct 3136381 cttcgccaac cgccagcact ttgccgctgt ttttatcaag tgcaacaacg gaaggttcat 3136441 tcagaacaat tcctttacct ttaacatgga tcagtacatt tgcagtaccg aggtcaatac 3136501 caatatccct tgcaaacatc tatttatatc ctccttgaaa atctgtttca cagtaaatat 3136561 ccacattgtg ccctaattat atatattatc ataaaatata gaaaaaaagt tggaagcaca 3136621 ataagttctt tacaaatttt tgcggatgtt ttatgaacga tttcaagaag gcaatgccag 3136681 gtgattacga ttgctgaaca ggctctcctt cgagaatttc atctttttta tatttgagct 3136741 ttgtcgcttc tcctcctctt aaatgcctga tggatttatg ataatcgagt atttctttca 3136801 cttcgtttgc caagtcgggg ttaatttcag gcagacgctc tgttaaatcc ttgtgtactg 3136861 tacttttgga aacaccaaat tccttcgcaa tgacacgaac ggttttcttt gtctccacga 3136921 tgtacttccc tatcttgatt gttcgctctt tgatgtaatc gtgcacacca ctcgacctcc 3136981 ctaaaatgga tgtgagaagt gtgaaatgag atccgtattc tgtaaagagt cgttcattat 3137041 gccgcttctt cgttgtatgg ttttaaaagt aagtttgtga aatatgccca cgatccctca 3137101 cctcaaacac tctctttgtt aggtttgtaa cagtgtatta gcattctttt gggaatatgc 3137161 taaaaactca ataaggacaa ggggtgaaac gaactttttc agattcagca aactatttcg 3137221 cgtcactaaa ttttcatctt tacaactatt gatcgctcct gtaaaatgaa ataagcaatt 3137281 agttacttag gtaagttttt tagaaggaga ccgacatgtc ctacgtcaac agacacctca 3137341 ttcatcaaat caaccaaagc gcccgcctga ttgccaagaa agccaatgaa cagctagagc 3137401 cattcggcct ttattcatct caatggtcag ttttatattg tttgcgtacg atcggaccaa 3137461 tgactcaaaa agagatttgg tcctatttaa atgtggaagc gccgactgtg actcggacga 3137521 tcaaacgcct ggaggagaac ggctgggttc agagacggca aggtgaagac aaacgggaaa 3137581 aacttgttgt cctcacaaaa gaagccgaga aaaaatacga agaaatcaat gtgaaaatgt 3137641 tgaaattcga ggaagagctg cttgcagatt tccgggatga agataaagaa gctttttctc 3137701 atttattccg catgttttta caacaatgaa aataaggaag tgacatacat ttgaaaaaag 3137761 cggatgcgat atggaccaag gattttatta tggtcctgct tgtcaattta tttgtgtttg 3137821 tgttctttta tacattttta actgtattgc cgatctatac actgcaagag cttggcggca 3137881 cagaatcaca aggcgggctt ttaatcagcc tgttccttct gtctgcgatc attacacggc 3137941 ctttctccgg agccatcgtt gagcgtttcg ggaagaaaag aatggcgatt gtatcaatgg 3138001 cgctcttcgc cctatcatct tttctgtata tgccgattca taacttttcc ctgctgctcg 3138061 gattgcggtt cttccaaggg atttggttca gcattttaac gactgttaca ggtgcaattg 3138121 ccgctgatat tattccagcc aaacggcgcg gtgaagggct tggatacttt gccatgtcta 3138181 tgaacctcgc tatggcgatc gggcctttcc ttggcctgaa tttgatgaga gtggtaagct 3138241 ttcctgtatt ctttacagcc tttgcgctgt ttatggttgc gggcttactt gtttcgttct 3138301 tgataaaagt gccgcaaagt aaggacagcg gcacgactgt attccgtttt gcgttctcgg 3138361 atatgtttga aaagggcgca ctcaaaattg cgacggtcgg tttgtttatt tctttctgtt 3138421 attcaacagt cacatcatat ctgtctgtat tcgccaaatc agttgacctt tcggatatca 3138481 gcggatattt ctttgtttgt tttgcggtga caatgatgat tgcacgcccg ttcacaggga 3138541 aattgttcga caaagtcgga ccgggcattg tcatttatcc atcaatcctg attttctctg 3138601 tcggactctg catgctgtcc ttcacacata gcggcttaat gcttctgctt tcaggggcgg 3138661 ttatcggtct tggctacgga tcaatcgttc cttgcatgca aacattggcg attcagaaat 3138721 ctccggctca ccgctccggt tttgcgacgg caacgttctt taccttcttt gacagcggaa 3138781 ttgctgtagg atcgtatgta ttcggattgt ttgtagcatc tgccggcttc tctgccattt 3138841 atttaacagc ggggctgttc gttttaattg ctctgcttct ctacacgtgg agccagaaaa 3138901 aacctgcaga ggctgaagga aaagtgtcta ttgcagaata acttgtcaga ctgccgggaa 3138961 atcccggcag tcttttttcc attaaaacac ggcgccctct cggttgaacg agagaacgcc 3139021 gcttatagca attattcaat gacaggccgc gcaggtgaat caggatctaa cgaaaaatca 3139081 taggacgctt catcacgaaa catcggatcg gcatatatgg attgttgatc gttttttgtt 3139141 gcttttcgat acgaagaaaa tgaatcatat tctttctttt tccacatcca tatgccgtct 3139201 tgatccgctt ccttgtggta cacgttatga ttgaccgtat taccttcgtt ttctgtaaag 3139261 tcgtttccga taaataatct ggaatcaccg gccgtcaata tattcttttc aattgtgttg 3139321 tttttcgtat cgtactgcag cagcagctgt ccgccgtaca gtccctttgt gtcattccgg 3139381 tacataatat tgcgggcaat cagagaattg ctggtgccgc cccgcttttt gtcatatcct 3139441 ccgattgaaa taccggtgta cgcattgttg tacactttgt tgtctgtgat ctgaatggca 3139501 tttgcatact ttcctttgtg ttcagacgtt gcttcaatcc caatatcgtt atcgtaaact 3139561 gtgttgttct taatttcgat atcgtgtcct ccatcgacat aaatcccgcc cgctgagtat 3139621 tcatctccat aagcaggatt gccgtaagtc gagttttgat aaactgtatt gttttctacg 3139681 actccgtttc gcacgtaatc gtttttatcc gcggttccct cataaccaat tagatcaatc 3139741 ccgatgttat tattgttgcg gaccacattg cctgcaactg tgaagccgtc gatattaccg 3139801 ttcagcacaa ctgcttcact cgctccaagc gtcagtttct caactgtatt gtcctcgatt 3139861 cggatgtctt tcatgctgcc agtcccataa actgcgattc cgtgagcatt tccttcatcc 3139921 gctgttgtct taatcccccg gatgtgatta tccttaatgg cgatatgact gctggaccct 3139981 gatacataaa tccctatagc agttgcttcc tcagatgaaa cagaaagatc ttgaattgtt 3140041 aaaccgctga tggcaatgtc atgtttatcg tgaatacgaa taagcggtgt ttcatattca 3140101 gcgttcgcaa cggattcacc gctaatcacg acgttttcat tttcatagtt tcggaatgtg 3140161 ataggctttc cgtccgtacc gctgtgcttt acatcaaggg tctcatgata cgtgccctcc 3140221 cgaatcatga cagttgtgcc ggcagcagcc ttctcagatg cgtgtgccaa tgtacgaaac 3140281 ggcttttctt ttgttccttc attttgatca ctgccatttg gcgaaacata cagataatcc 3140341 ccagatcctt cctcattcgc ttttgtctta tcataaacga aagcgaggat gacagacgtt 3140401 aaaacacccg ccaaaagaat aaaataccat tttctcattt tcgattccca tttcgtttta 3140461 gaatagattt ctaaaaccat tataaatgtt ctatttatgg aaaaccattt caaaaatatg 3140521 aaaatatacc gtctaaatag atcttattca gcctggcgga cctgcgcatg ttcaactgtt 3140581 tcaattgcca atgatgcagg cgggtgaaca cgcatcagaa caatgtagaa aagaaaggaa 3140641 atcagcacac ctacaaacca agaaatatcg tataagctct tcaatacagg aacatacatg 3140701 ccaatcagcg aaatcagcgc tcctaacatt gtggctgcaa acgcacggta attgtagccc 3140761 ttccaataca cataccgtcc tgtttcggaa tacaggtcat ctaccgagag ctcacgtttg 3140821 cgaatgataa aatagtcggc catcatcacg cctgccaccg gtccaagcat gccgcctatt 3140881 aagccaagaa acgcatacac gcttgtcgcg ctctccatca gcttccacgg aaccgtaaat 3140941 aaagcgagca acgctgtgat aaagctgcca cgtttgaaat tgatatattt cggcagggca 3141001 ttcgctatat cataagcggg tgatacgata ttcgccgcga catttacaga gatcgtggcg 3141061 atgcagagtg tgatcacgga caagacgatg acataagggt tatcaaaccg cgccaaaata 3141121 tcgacaacat cccaaatcgg ctctccgaac gcgacctgcg agccggaggt caccgtaata 3141181 cttgcgaatg cgaacagcgc aaacgttccc ggcaaaccgt aaaattgtcc tttgatttgc 3141241 tctttttgtg tttcagcaaa ccgtgtaaaa tcaggtatat ttaagatcaa tgtcgcccag 3141301 atgccgatga tgccagtaac tccggcagca aacggccaga atgtttctga aaacgtatga 3141361 aactttcctg gttgagagta tatcgggccc aatcctccag caatatcaac ggcccaccat 3141421 accatgccgc caaataccag atacactaaa ggccctgccc acacctcaaa acgtttaatc 3141481 gactccatgc cgtgatgcaa tacgagtaaa tgaatggccc aaaagaatac aaaggaaagc 3141541 aaaccggaca agtgaatgcc gagaatgttc cactcgccgc caatttctcc ccaacctggc 3141601 cacatattca aaagcaaaat gttcagtgcc gtgctacccg caaaggtctg gatgccaagc 3141661 cacatgatag ctgtaaacgc ccttagaagc gcggggatat tcgcgccgta tatcccgtaa 3141721 gaagcccgaa tgatcactgg aaacggcagc ccgtattttg tccccgcatg gccgtttaag 3141781 gcaagagcgc caaataggat aagtgatgcc gtaataatga tcgccagcac ctgccaaggc 3141841 gaaaggccga tcgcaattaa tcctcccacg gtcgcgtagg tcggtatgtt atgtatacat 3141901 cccatccaaa tggaggcaaa gttcattgct ttccacgtcc gtttttcctg tcccaaaggc 3141961 accagatctt cattgctcag cctgttggat tgctgctgac tctcttttaa tttcatagcc 3142021 ggctcccctt tccatattgt ctatatgtcg tcacacgtta tgttttttga cattagatgt 3142081 cacttaatat aactgaagag tcagacaata acactggcta tgatatacaa ttttcccgtt 3142141 tgtatttgaa cagcttaaac aagaaaaaga gacagacctc agagcccgtc tctttcttaa 3142201 gatgcagttt tcattaatgc agcaaatctc acagccatta acaggcttgc tccgcccgct 3142261 ataatcataa tgattcccat catatcaaaa tgggctgccg tgatttcttt accaaaaaga 3142321 atgccaagga tcaccgaaga caaaatcgat cctaggtaac ggcaggtttg aaacaggcct 3142381 gaagtcgttc ctaccatgtt ggaaggactc gtttccagca tcgctgcctg aagcgcgaca 3142441 ttgcccagtc cgtagcctat acccaagagc gacagaatga ggcctttacc gatggtctgg 3142501 acattgataa aaaagatggt taagagcacg gctccagccg tcatcaaaag cgctcccgca 3142561 aagatcggct tgacgacacc agatcggtcg atccatttgc cggttagagg tgacacaacg 3142621 atgctcattc cagacataaa cagcataaac aggccgctcg tttgaacaga aagatgcatt 3142681 tcatcctgaa agtaacttgg caaaccaaaa aataaacaat agaagaaaac attcaataaa 3142741 ataaactgaa catacacggc tgacaggttt cgctgtgttt taaacagacg gacatcaata 3142801 aacggcttat ccgttttcag ctcgcgccag acaaacgcac agagcagaag caagccaagc 3142861 acaccttcaa ccgcatgcgg cgacgtgctg aacgacagca aaaaggatag aaggaaaatg 3142921 attcccccgg caaataaaac aattccaaga atatcgagct gccgaataat ggttttgatt 3142981 cctgcccctt ttttctgatc tttcgggaac atatacaggc ccaataagaa gctgaggata 3143041 ataaacggca aattaacgat aaagatcgcc ggccagcctc cccatacaat caaaaacccg 3143101 ccggctgtcg gccccagcgc cgtcatggcg gacgcaaaaa tagagagtac agccaaggct 3143161 gaagcttggc gctcatgaat atgattccga atcaagccga cacctgacgg ataaatcgca 3143221 ctgctcccca ccgattgaaa cagccgcatg accaataatg tcataaacgt cggcgcaaac 3143281 ggcgccccga tggcagaaac cgcaacaaga ataagcccga ataaaaacaa gcgtttccgc 3143341 ccaatcaaat caccgagctt tcccgttacg ggctgcgcta cggcactcgc caagtaaaac 3143401 gaggaaatca gccaggaaac cgttgtaaac gagaggtgaa actcatgctg gatgctatgg 3143461 agcgcaagag agatcataga cgagttcagc ggattcagca ttgttcccga agccacagct 3143521 gttaaaaaaa cagctcggct ttttttcgat aacatcattt cacttgttcc agaaactctt 3143581 ccgttgtccg cgatttaccg attctcggga aaataaagcg cagtgtggct tcatgctctt 3143641 catcgctaaa tgtggacatg gcatctgtaa taaaaatctg ctgatagcca agctgaaatg 3143701 cctcccgtgc tgtgctttcc accccgatat tcgttgcgat gccgcacaat acaatcgtat 3143761 caatgccgcg acgtctcagc tgcaagtcta aatctgtgcc aaaaaaagca ccccattgcc 3143821 gttttgtcac agtataatcg ccatcctgca caccgatttc cggaacaaat tcggcccagt 3143881 ccgccggcat ttcccctgaa cctccctgcg caggctcatc cgtttgcggc ttcagggcgt 3143941 ccgctccatc atgaaaggct acatttacaa agctgatgaa cccgttatgt ttccgaaatt 3144001 catctacgag ctttttcgcg ttcgggacaa cctggccgct ttgatcaatc ggcacaattc 3144061 ccttttgtaa atcaatgata accaatgctg ttttttgaaa atcaatgttg agtgtattca 3144121 tcatacgtct cctcctgata ctgttagtgt ttctcacatt gcatatttta ctcttcacac 3144181 tgcctaagtt cttttatgat gcttgtgaaa ttctcagaag gagcgttttc tcatgatttt 3144241 tcttttatgt agtagtaaca ggttgtgcat acgaacaaac cggcaagcac tgtaatcata 3144301 aagggcgtca tcgcttcatc acctgcctgc tgtctatcgg ttcctgcctg aaaatgccca 3144361 tgaatttgcg gcggtccatc caaagcagga taagacacat aaccattaat atcgtgctaa 3144421 gatcctgcac gccaatatca aaacaatagt taatcaagac gatgttcaca ataatgggca 3144481 taaaaataac cgcccctaat gcagccgttc gcggaatcag taataaaaca gctgccagga 3144541 tttcaccaaa acctataaac agttcataga catgagaata accgaaaaat gtccacgcga 3144601 tcgtaaaccc cttcccggca gccgcctcga tttcaggcgt cacctcgcca aactggccaa 3144661 ttaccacttt cgccagaccg tacacgaaaa aattaaaggc taaaaacaat cggaacgtcg 3144721 cgggaatcga cttgcgtacc gctttcctca gcctgccgcc tttattcatc atacatcccc 3144781 ctcagtgtat tatttgatgt agtacactta atacagtata gagtattcta attaatgtca 3144841 attccctttt cagctcatat gaatagtttc ttttatagat acaaagtctt atatcgcaaa 3144901 aaatgccatt ctccttcctt tccatccctc gataacattt ctcaaaaacc atgtcaggaa 3144961 atcttacatg aaaatgtttt atcattcttt tttctctata atgaagaaat ataataattg 3145021 ctttttattc tgaaagatac ggaggaatga gacatgcaaa tgggcgatac agtttttatg 3145081 ttcttttgcg ctttactcgt gtggctgatg accccgggat tagcgttatt ttatggagga 3145141 atggtaaaga gcaaaaatgt gctgagcact gccatgcaca gtttctcttc cattgccatc 3145201 gtttccatcg tttgggtgct gttcggatat acacttgcct tcgcaccagg caattcaatc 3145261 atcggcgggc tggagtgggc aggcctcaaa ggggtcggat ttgatccggg agattacagc 3145321 gataccatcc cccactcgtt atttatgatg ttccaaatga cgttcgccgt tctgactaca 3145381 gcgattattt ccggggcttt cgcagagcgg atgcgattcg gcgcttttct tttattctcg 3145441 gttttatggg cctctttggt ttacacaccc gtagcgcact gggtatgggg cggcggctgg 3145501 atcggccagc ttggagcgct cgatttcgct ggcggcaatg ttgttcatat ttcctccggg 3145561 gtggcaggac ttgttcttgc cattgtgctc ggcaaacgga aagacggtac agcgtcttct 3145621 ccgcataacc tcatttacac cttcttagga ggagctttga tttggttcgg ctggttcggc 3145681 tttaacgtcg gcagcgcatt gaccttagat ggtgtggcca tgtacgcgtt catcaacaca 3145741 aacaccgcgg ctgcagccgg gatcgccggc tggatcttag tagaatggat cattaacaaa 3145801 aaaccgacaa tgctcggagc ggtatctggg gcaatcgccg ggcttgtcgc cattacgccg 3145861 gctgccggat ttgtcacacc gttcgcttcc attattatcg gcatcatcgg cggagctgtt 3145921 tgtttctggg gagtattctc gcttaaaaag aaattcggat acgacgacgc gcttgacgcc 3145981 tttggcctgc acgggatcgg cggcacatgg ggcggaatcg caacaggatt attcgcaaca 3146041 acctctgtta actcagcggg cgcagatggg ttattttacg gtgatgcaag cttaatctgg 3146101 aaacaaatcg tcgccatcgc cgccacttat gtttttgtat ttattgtcac tttcgttatt 3146161 attaaaattg taagcctctt ccttcccctt cgcgcaactg aagaagaaga gtcacttggg 3146221 cttgacttaa cgatgcacgg ggaaaaagca tatcaagatt ctatgtgagg agtgacgcta 3146281 tgagcggtca aatgttcaag gtagaaattg taacgcgtcc ggcaaatttt gaaaagctga 3146341 agcaggaact cggaaaaatc ggagtgacct ctctgacttt ctccaatgta cacggctgcg 3146401 gccttcaaaa agcacatacg gagctctatc gaggggtaaa aatagaaagc aatgtatacg 3146461 agcgtttaaa aatagaaatt gtggtcagca aggttcctgt tgatcaagtg acagagaccg 3146521 ctaaaagggt gctgaaaacg ggatcaccag gtgacggtaa aatatttgtc tatgaaatca 3146581 gcaatacgat caacatccgc acaggcgaag aaggacctga agcactttaa tatcggtacg 3146641 agattcggac actccggatc tctttttttg tgcacagaat ccccccagaa accgcgattc 3146701 ctcttcgaat tctcttcaag cgccgttatt tcagacaatc tctattttta tttgaaactt 3146761 ttcatgagta agattagtct actaaatata aaaatgtaaa aggtgattat ttgaactacg 3146821 aaatttttaa agcaatccat ggactatctc atcacaattc agttctcgat tccattatgg 3146881 tcttcatcac ggaatatgcc attgtcgcct atgcccttat cctattggca atctggctgt 3146941 ttgggaacac acaaagcaga aaacatgtgc tatacgcagg catcacagga attgcaggcc 3147001 ttgtgatcaa ctatttgatt acgcttgttt atttcgaacc gcgcccgttc gttgcgcata 3147061 cagtgcatac actgattccg catgctgcgg atgcttcatt tccaagtgac catacgacag 3147121 gtgcattagc gatttctatt gcgatgcttt tcagaaaccg caaaatcggc tggccgcttg 3147181 tcatttttgg gcttttgaca ggcttttcga gaatttgggt gggacatcac tatccggtag 3147241 atgtattggg cagcctcgtt gtcgccatca ttatcgggtt ccttttcttt agattttcag 3147301 atctgcttcg cccgttcgtc gatttggtcg tgaggatcta cgaagccatt atcaataaac 3147361 tgacgaaaaa accaaccgat caaaatttct aagaaagaca aaagccggcg tctgaaatca 3147421 agacagccgg ctttaatatt tctcatacat ctcttgtttt cttcgcttcg ccaacacata 3147481 taaaccataa aacaacccaa ttccaacagc atcgatgagc acatcccgga tacaaccatt 3147541 cctgctgaag aagagctgaa gaacttctgt gaaaaaagca aacgcaaatg agccggctgc 3147601 agctgatctt atgctgcccc gctgtttcca cagcaaatat gtcagcacaa agaaggaaaa 3147661 cgcgtgtccg attttttgaa taaacgcttc aggtacagta agctcagtaa aatccataac 3147721 taaaaattga gacagatcag ggtgcggctg aaaatgaaaa gccaccgttt gcgatacgac 3147781 catgccgctg aagctttccg tacagacaga aagcaggata aaaaagatcc agcctgcgag 3147841 caataggcgg ttcatgacat aacctccttt ataacgtacg tgcctacatg taactacata 3147901 gacggtaaaa caaagcaaaa agtaacagaa aaaaacgccc atcacaagga tagacgtttt 3147961 cttcattaag actgttcagt gtcttctgtt gtgctgcttt ctttagaacc agatttgtca 3148021 gttgaatcat cctttttctc accggatttt tcttctgttc ctttttcagt tgatccgtcc 3148081 tttttctcgg aagattgctg aatggattct tctgtttctt gggtggcagc tttttcaata 3148141 gaagaaactg gtttgtccat aaagtttaac ggattcattg caaccccatc tttacggatt 3148201 tcaaagtgca cgtggtttcc gctgtcttca ctgtaaaggt tcttgccaga ttttccgatc 3148261 acttgatttt gttttacttt gtcaccttgc tctacgctta cttcggaaag agattgatac 3148321 acagtcgata aaccgtcggc atgttctact tccacaacat atcccagcac tggatctttt 3148381 tcagctttaa caaccgtacc gctcagagaa gcagagacat cgaaatcttt tccgtctttc 3148441 tcagctaagt caattccttt gcttaggctg tacgtgttat tataggtaac gagtgctgct 3148501 tctttctctt cttttgcggc atcggtttca tagaactttt tcacaacaga aacgttttca 3148561 gaatcaacaa ccggcattgc gacattttcc attgactttc ctacttcaac tgcatcgtcg 3148621 ttgttgtcat atgcggagtt tccgccgtta tcagccaact gatcctttac ctcatcattt 3148681 gatactgatt gataccaaag gacagctgtt aaaatgacgg ccgcactgac taagtaaatt 3148741 gcagggaaca cccagcgttt acgaaaaaac tgctgaagtt ttttgacttg agaagttttc 3148801 ttttcttcct ctctcattgt ttcatcacct cagcaacatt ctgaacactt ttctgaaaat 3148861 atatacaacc tatccaaaaa aactttttta gatgtagttt gcacagactg aacgaaaata 3148921 tgtatttttt tgagaggagt gccaaaaacg tatgaacatg acattgcgtc ttgctgaaca 3148981 tagagacttg gaggctgttg tggcgattta taattcaacg attgcttctc gaatggtaac 3149041 agccgatacc gaaccggtaa ctcctgaaga ccggatggaa tggttttcgg gacatacaga 3149101 gtcacgtccg ctctatgtgg ccgaggatga aaacggaaac gtcgctgcct ggatcagctt 3149161 tgaaacattt tatggaaggc cagcctataa taaaacagcg gaagtcagca tatacattga 3149221 cgaagcatgc cgcggcaaag gtgttggatc atatttgctt caagaagcgc tccgcattgc 3149281 cccgaatctt ggcatccgct cacttatggc cttcattttc gggcataata aaccaagcct 3149341 gaagctgttt gaaaagcacg ggtttgcaga atggggacta ttccccggca tcgccgaaat 3149401 ggacgggaaa agatacgatt taaaaatttt agggagagag ctttcatgat tagtctggat 3149461 aaagatgaaa acgaaattga acatcataat gaagaaaata gccttgttga acaggagact 3149521 gcacctgttg gacaggagag ccgccagctg agcgcctccg ctgtcaagtc gctatccgac 3149581 attgccaagt ggggcaaaat ttctggcatc ttgttaatca ttatgggatc gcttgtcact 3149641 ctgtctgttt tgatgacagt gattggcgcc atcccgggcg tactgctcat tatttcaggc 3149701 gtatttttga tgcgctcagc aaaagcagcc gcggaagccg aaggaaatct aaccggcagc 3149761 gctggcgaaa gcatgcttga aaattacggg acatttataa aaatgcagct gttttatgca 3149821 gcatccagta tcgttactgt cctgatcggg atcattgtag ccattttcgt gctggtggta 3149881 atcggcattg ctgcttttga gaacacgcct tcgtatgatg atccggattc ttattattat 3149941 gaggatgatc cggtgtttga ataatgatga gacaggacag ggcatgagtt ccatataaac 3150001 ggaaccatgc ctattttatt tgactattca aagcaggccg gcgtaaacac caaatcctga 3150061 agcaagcata caatagacat ctctagtaga ggaaatcaac aaagcaacgc tgttacccag 3150121 aaatgaatat caaaaaaacg gatgaagtcg gaatcaatcc gaaaccgcac tttttatttc 3150181 gggtgtctgc atgcaaaaaa acacacccgg atcgtctgga aaatctcaac aatccgggtg 3150241 cagatcttct ttaatacatt tttttgcgtc tgtcttcctc agtcaaaaat tcaacaaaac 3150301 tccgcatcgc aaaaggctct tcctttattt gtcgtgcgta ggagcttttc cgctcttctg 3150361 aaaggatttc gctctttttg atcctgttca gcatatagat gtgaaccgtt ttttggattt 3150421 gtttatgctg atagcctgcc tctttaaaaa atgcgagccc gagcgccgcc aaaagggcga 3150481 atatgcctgc gctgatcagg gactccctgt cagctgaagc atgaaataga aaagcagcta 3150541 aattaaagag agagaatgca gcaagcggaa tagcaagaaa acggtaaatg acggtttttt 3150601 tcatgaaagg ctgtacggcc ttttgaattt tttgcatttc tgttttgatg aaccccggca 3150661 tttgttcgac tctgtaaaag ttcatataat cctccccctt tatttgatgt ttcaagcttc 3150721 acgaacgtta tcatatgtgt ttattttaac gcaggtgcaa gctggtttta aagaaatctg 3150781 cccgtatttt tcacgaagaa tctggatcgc cgctctttat tcttttaaaa tgtgagtgtt 3150841 ataatttgta atgggaatca gatcactgtt attcatggaa tactaatggc aatcttcttg 3150901 ataaatatga atgagcgggg ttacaaagtg agtatttctt ccatcctttt atcacttttt 3150961 ttcattttaa atattctttt ggccatcatt gtcatcttca aagaacggcg cgatgccagt 3151021 gcatcttggg cgtggctgct tgttcttttc tttattcccg ttttaggctt tattttatac 3151081 ttattattcg gccataatct cagacgcaag catttgtttc aatgggaaga ccggaaaaag 3151141 attggaattg aaaggctgct gaagcatcag cttgaagatt tagaaaccaa gcaatttcag 3151201 tttaacaacc gggcaacctt tgataacaaa gatttaattt atatgctgat tatgaataac 3151261 catgctgtgt ttacagagga taattcagtt gacgtcatta cagatggacg ggataaattt 3151321 cagcggctgc tgagtgacat ttcaaaggct aaggatcata tccatttaca gtattatatt 3151381 tataaaggcg atgaattagg caaaaaattg cgggacgctc tcatccaaaa ggcgaaagaa 3151441 ggtgttcagg tcagagtgct ttatgatgaa ctcgggtcca gaacgctgag aaaaaagttt 3151501 tttaaagagc ttcgcgaggc tggcgggcat gtggaggtct ttttcccgtc aaagctcagg 3151561 ccgattaacc tgcggctgaa ttaccggaac catcgaaagc ttgtgatcat agacggtatg 3151621 accggttatg tcggaggctt taacgtcgga gatgagtatc tagggcttaa tccgaaattc 3151681 ggttattggc gggatacgca tatccggctg caaggaacgg ccgtgcacgc catccaaaca 3151741 cgattcatcc ttgactggaa ccaagcttct catcaccata cgctgacata tattccaaat 3151801 cactttcctg attacggccc aaaaggcaac gtcgggatgc agattgtcac aagcggccct 3151861 gattcggaat gggaacaaat taaaaatggc tacatcaaaa tgatttcgaa cgccaagcgt 3151921 tccattttga tacaaacacc ttattttatc ccagatgcaa gcctgctgga tgctttaagg 3151981 atcgcttgcc tttcgggcat tgacgttaac attatgattc cgaacaagcc cgatcacgcc 3152041 tttgtatact gggcgacact ttcgtatatc ggcgatctgc tgaaagccgg agccactgtc 3152101 tatatttacg ataacggctt tattcacgcg aaaaccatcg tggtggatga cgaaatcgct 3152161 tcagtcggca cagcgaacat tgatgtccga agcttcaggc tgaattttga ggttaatgca 3152221 tttatttacg atatcaccat tgctaaaaaa ctggtttcaa cttttaaaga agatttgcta 3152281 gtatccagaa aattcaccta tgaggagtat ctgcagcgcc cgttgtggat tcgaataaaa 3152341 gaatccgtct cgcggctgtt gtcgccgatc ttataagatg cgtaaacccc cggcctttac 3152401 ggccgggggt tttcctgatg gtcacagtaa atgatgattg cctcccgcaa aaaagcggca 3152461 agaccttctc catattgatt gattgaatcg gtaaatcgct cgtcagtgat atacacttcc 3152521 ccgagtcctc tgaaaatgtc gagtgtgcaa tcgtaatgat attggcaaat atgatcgcga 3152581 aatgccccca cagcggcctg aatctctgca tcatcgggcc catgcttcat tcgcgccgca 3152641 attcgtctgt aaatcgaatc aaattcagcc atgatcgtgc gccaatcatc tgccgagtat 3152701 gcagatgtcc ttttctctgt ttcttctgcg atttcctttc catacagctt tctgacttca 3152761 tcagcgtatg tctgctggtg ctcttcaatg tctttcatgc ttaatccggc aaataaatcc 3152821 ctcttattca tcgtttcccc tccatcaacg gacaaaagcg tcctgtcaat tgtttgaatc 3152881 atctcatcca ttctttgttt tttcttcatc aatatctcct tttgcgactg aagtgccgct 3152941 ttccggtcaa aattcggatg atccagcatc tctttaatct catccagacg aaacccgatt 3153001 tccttgaaaa ataaaatctg ttgcagtctt tccaggtctg cgtcactgta caaacgatac 3153061 ccagcatcag taagcgctga aggattcaga agctcaatat tgtcatagtg atgaagcgtc 3153121 cgaatgctaa cgcctgatat ctccgccact tgtttaactt gatatttcat acataacacc 3153181 tcctcttttt tatcgtaaac aatcacgcaa cgttagggtc aatccccaaa atgttatttt 3153241 ctatatacaa aacttctcac aaatagtgta taaaagaaaa gtgagtattt ttttgtaaag 3153301 gggagccagt atacatgaat cctgaaacaa tgaacaaaac cctcatcagc atttcgaaat 3153361 ggggaaaagc tacaggcatt ttatttatta ttatgggcgc aattaccgcg ctttcaggcg 3153421 cgttcttttt tctaatcggt gccgtgccag gcgtactgca aattatttcc ggtatctttt 3153481 tgatgaggtc agctagggaa gcaggccaaa tggctgaaca caatagcgga cagtctgaag 3153541 acttaatgct ggagaattac gcgaaattcg taaagatgca agggatttat ttgatcgtaa 3153601 gcattgctgt atccattctt gcgattatcg ccttcttcat ctttttaatg cttgggattg 3153661 ctgacggcct tttcagcgat acgtacagca cttattaatg agaaaaaccc ggagctggct 3153721 ccgggttttt tattattccg cttcgcttac cactgtgaag cgttcatttt tgtgttcggg 3153781 atgttcaagc tcgtccaaca cggcaatggc ataatctgca tagctgatat agctgtctcc 3153841 ttttgcattt acgatgacat tgtcttttcc tttttggtaa gagccagtcc gttttcctgc 3153901 tggatcaaaa aatgccgcag gactgaggaa cgtccaggaa atggagtctg tctgctgcaa 3153961 atctttcagg ttctcgcctt gatttgatgc agttggcaaa tattctttcg gaaattccgg 3154021 cgtatccatt aaacgggttg ttttggcttc atcaacaaac aggcttcccg ctccgccaac 3154081 aacaagcaat cttgtgtgct tcgcgtcctt taaaatgctg atgagtgctc ttcctgcttc 3154141 aacatgaaga tgttcttggc cgggtgctgc tccaaaagcg tttacgaccg cgtcgaaagg 3154201 cttgatgtct tccgcagtca gttcaaacac atctttttcc aaaatcgcta cgtcttgctc 3154261 ctgcactttt gaagcgtttc tgacgatggc tgtcacttca tggcctcttt ttttcgcttc 3154321 tttcaaaatc tcgtttcccg ctttcccgct tgcgcctata ataccaattt tcatttttca 3154381 tttcctcctt atttgtaaca attttagtta catgttagcg gtgagaagtc atcccttttg 3154441 attaaaagag atgattcata acatctttta atgacttgct tgccagttca ttttccatcg 3154501 ctctttgcac actttcaaac gtttcatcca gagcgttctg aatttttttc cctaccggac 3154561 atttcggatt cgggttttca tgaaccgcaa agagttcttc ttgcttttgg acagcccggt 3154621 acacttctaa aagagaaata tcagcaggat cttttttgag gcttgcaccc ggcaccccgg 3154681 cgcgtgatgt gagaatatca gcttttttca gcaggctgat cattcttcgc acaactaccg 3154741 gattcgtgtt gacactgtct gcaatgattt ctgaagatgt tttttcatcc atcgagatga 3154801 gggataaaat atgaatggca acagcaagac ggctgttaat catgtttttt caccaccgtt 3154861 gtaactataa tagttacatt tgattcgttt gtcaacatct aatatacact aaatacatgg 3154921 gttttgtgca ccgtttttag tcaatagaac ggccggatgc actccggccg cgtcttatca 3154981 aaataagaaa tatctttgtc caagtgggac ataatcgaca ggctggcaag acaattcctc 3155041 cccgtcagca aagacctgat aggtttttgg atcaatctca atcttcggca aagccgaatt 3155101 cagcttcata tccagcttgc tcagctttct gatatttttg actggagaaa tccttttttc 3155161 cagccctaag ctttccgcca caccacgctc tatgcttgcc tgagacataa atgtaatcga 3155221 ggttgagcgg ttggcttttc cgtaagacgc atacatttgg cgcatgaaaa ccggttcagg 3155281 agtcgggatg gacgcgttcg gatctcccat ttgcgcacgt gcaatcatgc cgccctttaa 3155341 gaccagttcc ggtttcacgc cgaaaaatac cgggtcccac agaacgagat cagcaagctt 3155401 ccctttttcc accgagccga cctcatggct gagcccgtgc gtaattgccg gattaatcgt 3155461 gtatttggca atgtaccgtt ttgcgcgcac attgtcattc ccgttttcac cggcaagagc 3155521 gccgcgctgt tttttcattt tatcggctac ctgccatgtt cggatgatca cttcaccgac 3155581 ccgccccatc gcttgggaat ccgatgatgt catgctgatc gcacctatat catggagaat 3155641 atcctccgcg gcaatcgtcg ccgccctgat tctggaatgg ctgaatgcca catcttcagg 3155701 cactttcgca tctaaatggt ggcagaccat catcatgtca agatgctcat ccatcgtatt 3155761 aacggtataa ggaatggttg gcgttgtaga tgacggcaga atgttcgcgt aagaggcgag 3155821 cttcataata tccggagcgt gaccgccgcc tgccccttca atgtgataag tatgaataac 3155881 ccggtccccg atcgcgtcga gcgtgttttc caaaaagccc gcttcgttaa tcgtatcggt 3155941 atggatggca acttgaatat cagcctcgtc cacgacttcc atacacgttt taatggcgct 3156001 tggcgtcgtt ccccagtctt catggagctt aagaccgatg gcgcctgctt ccacctgctc 3156061 gatcagcggc gctttatcgg atgcattccc ttttcctaag aagccgacat tgatcggaaa 3156121 ctcctcggcc gcttccagca tcctcgccat ataccacgcc ccggacgtac atgttgtcgc 3156181 tttgcttcct gtagcgggtc ctgttccgcc tcccaaaagg gtcgtcacac ctgaagaaag 3156241 cgcaacttcc atctgctgag gacaaataaa atgaatgtgc gtgtccactc ccccggctgt 3156301 taaaattttg ccttcaccgg aaatcacctc tgtccccgct ccgatgacca tgtgcggatc 3156361 gactccatcc atgatatcag gatttccgct ttttccgaca ccgacaatcc ggccgtcttt 3156421 cacaccgaca tccgctttga caatgcctgt gtaatccaat agcacgacgt tggtgataac 3156481 caaatccaaa gcgccgtcct tccctgtgat tctgccgttt tggcccatgc cgtctcggat 3156541 agtttttccg ccgccaaaga tcatttcttc accgtatact gtgaaatcct tttcgacttc 3156601 gatccataaa tccgtgtcgc ccaatctgat tttatcgccc gttgtcgggc caaacagttc 3156661 cgcatattcc tcccgtgaca ttttcatcgg attacaccct ccatccagcc ggcttgtttt 3156721 aagttggcca acgttttttc tttgccgcgt tcatcgataa acgtgtcggc cattccgttc 3156781 agccctctaa ttgtcttgcg tcctctgatt tccactagtg agaccgtttt ctgctctccc 3156841 ggctcaaaac ggaccgacgt gcctgatgga acatcaagac gcatgccgat cgccagctca 3156901 cggtcaaata ataaagcccc gttggcctcc gcaaaatgaa aatgcgaacc gacttgaatg 3156961 gagcgtgatc cggtgttttt taccgttacc tcccgtatct cacggccttc attaatcgta 3157021 atggttccct cagcaatttg aaatgctccc ggcttcatga cttcacctcc gcagaaattg 3157081 gctgatgtac cgtaacaagc tttacaccat ccggaaatgt ggcctccacc tgaatgctgt 3157141 ccagcatctc aggcacaccc tccatcacat ctttttccgt taatacatgg cggccggctt 3157201 ccatcagctc tgctactccc ttcccatcac gtgcgccttc cataataaag caggtgatat 3157261 aagcagcagc ctcaggatag ttcagcagaa cgccccgcgc ctttcgctgt ttggctaatt 3157321 cccccgctgc aaaaatgagc aatttctctt gttcaactgg tgtcagtttc atctgtagtc 3157381 ctccttcttt tgtcatataa agcagatgcg gctactacga atttgcggaa cagtcaggcg 3157441 ggacatcacc tccctttctt cgagaatggg ggtcatacgg taagatgcct ttcaaagcgg 3157501 catgccgttt cttcatcagc cttgccatgg tcaacaaccg ttcccctgtc gatcacggaa 3157561 agatcagatt aacgcgtttt ccagactgcg ctcgactaag ataacaaatg tctttttttc 3157621 tggaaatttc tataataact tgtctgacta gttcgacaat taaaatctga attccttcca 3157681 attgtttatt aagtaaaata tttttcagat ttaccatcag cgctctggtg attgcaagct 3157741 gctgctgttg accgcctttt cgttttgaac aaacgtttga ttaaaacaaa tagccccctc 3157801 tgtttagccg gagtcggcct aatacagcga caatctgccc cgggcgaagc taaggctgtg 3157861 caaaaccatc gattgatcat aaccagacgt tacattcctg atggcagccc gttgttttgc 3157921 tccgcaaccg gaagcatggc atggaggcca gtctgaggcg ccgacctcca cgataccgag 3157981 aacccgacta ttgccattaa ctccgcatca tggacggtca cttcgctgat cgccaccgtt 3158041 cctcttaatg agtgaagaat tccggccttc actgaatccc cgcttgtgtc gatatcaact 3158101 gttttctcgc actcccgtgg cttccgacac tttcttcggt gcagtacatt ccgtcatcaa 3158161 aacccctttg tttgatttct tcaaatgatg ttataaaagt ttacaactta tgtcatcatt 3158221 atatagaaga ggcctattaa ttcaaagaat atttaaaaaa tttagttacc ttgaccaaat 3158281 cagcttcttt ttttgttata tttattcaca tcagaaaaag cgaaaaaaaa agacaagaaa 3158341 catttcgttt cctgcctctt ccgtacgatt aatctttatc tgaaaattta tccttggctt 3158401 tcccgatatc cttttggatt tcgccttttg ccttatcttt tttgccttca gcctgcatgt 3158461 ccgttctgtc agccatatct ccgactttat ccttcacttc tcctttggct ttattgaagc 3158521 cgcccttcat tttgtctttt acactatcgt tacccatgtt aattctcccc tctcaattat 3158581 gtgtgtactt gttaacttcc cgatctgaga ggcaataaac attctaatgt tatttatcga 3158641 tttcgtagcg ctctccgtaa cggagcacct tgtatatcgc cagcccgtct gatgactttt 3158701 tctccgaata tcggaccggc agcagggcaa aaaacacata atacgtagaa aaatagacaa 3158761 actgatagaa aaacacattc ggctttaata cactgtgtat aatcagcaga ttgattgcaa 3158821 aaatcgtgat gaggttaaac aagcagcccc ctgcatacac gagtgcattt gagaatcgat 3158881 tgtcaatttt caactccccg taccggcaaa aagaatcgat aaaataaatc gttctgaacc 3158941 gtatgggtcc aattttaagc agcgtttttc ccatgcctat atccaacgat ccctttccgc 3159001 caaaaataaa agccataaag ctgtgccctg aaacatgtat aatctgtaca agcggcagaa 3159061 caatgaggaa agaccacaga aacttcacca tatcattaaa accaaacatt gaattccccc 3159121 tcacatgcat atctgcatcc caaaacggct tttgttcaaa aaacagtgct gtagcgattt 3159181 ttcctgttct ccccggaaat aaacgttccg atgctcccct ttttttgcat aaaaaaaaac 3159241 catctgccag cagatggttt tgtctcatac ttcatataaa caatcgttcc tttgaatcat 3159301 ctctctcatg ctgaccgctt tttcataaaa atacaccgct tctttatatt gttcgcgatg 3159361 actgaaataa gaggcagcat ctaaagcaaa ttcttcaata tatacataca ggcccttttc 3159421 ttccatataa tcaaatactt cttgaatcat attcaaattg acagattcca catataatgc 3159481 ctgcagaaat ttatattttg ccagactgaa gaagtcgttt cgtttttggg caatggcaat 3159541 ccctttttca tagtaccgta tcgcggcttc gctatcttgt tttttgaaaa gaacgcgagt 3159601 caggctgaag agcgcttttg gaagctgttc cagctgataa tcctcgaaga caggaagcgc 3159661 tttttcaaag tattcggcgg cctgatccag ctcccccttg tcatcatagc aattaccaat 3159721 attataaagg gctgatccga tcaaacgggg ctgtccttcc aataaagcaa ggcgatacgc 3159781 gtcatctaaa tgttcaagcg ctttttcata atttctgtag tcaatgtagt ttcctgatat 3159841 gacgaaatgg cattgaattc ttctgactct gtaaaaatcg tgagccttat acgtctccag 3159901 cgcctgtacg gcatggttca tggaaaagtg cgtctgcttc ataatataaa agacttccgc 3159961 cactttaaaa tgaaattccg ctctttcaat ttcatcttct acaaacgcaa gcatcttctc 3160021 agctttccga taaaaggata tagccgagat gtaattgttc tgttcaaatt cgtacattcc 3160081 tctaaacaag tgaaaataat actcagataa tccggagatg ctgtcctgat tgctttccag 3160141 cgttttgatc aattcacgat attgaagctg agattcctcg tgcaggtcag gctttacata 3160201 atccagcata atttggtgcc ggtagctgat cagctgataa tacaggagaa gcagctgatc 3160261 ctcttccatc tgttcgatat ctagatcaat ttcttctttc agttttacgg catcagccac 3160321 ttgaaatgct aaaatgtgct tataccactt attgattttc actcctactt gagatgacgg 3160381 gatctcgtac gcggccatgc ccctccaacc ctttctattt tctaattggt tatattttat 3160441 cataatgtat ggctttggaa ttaaattttc ttacaatgat tccttcttta tgcctatcct 3160501 tatatatttc ggtttttcta cgtatttttt gcactcggat tctaataaaa aagcttaccg 3160561 gacagtgccg ataagctttt gacttcaaat taaccgccaa tataagacat ttccactttc 3160621 tttttgccag atgcttttga tagcgtacga tcgactgaat actgatcgat ccgatttttc 3160681 catactgtcc cgatcatttc tgatagttcg tcatcactta attcctggcg aaccggagct 3160741 ctgaggtcaa atccgcttga agcgaataag caggtaaaca gctctcctct cgcagaaaga 3160801 cgggctctgt tgcaagatcc gcagaatgca tcagatacag atgatatgac gccaatttct 3160861 ccggagccgt ccaagtagcg gaatctggaa gccacttcgc ctatataatt aggcgctatc 3160921 ggctcaaccg gcatgtgttt attgatcaaa tctatgattt ccgcctttgt catgacgtct 3160981 ttcttttccc attggttggt gttgcctacg tccataaatt caatgaatct caggatatgc 3161041 cctttttctt taaaataacg ggccataggc agtatatctt tttcattgac gcccttttga 3161101 acgaccatat tgattttaac accgagcccc gcttgcttcg ccgcttcaat gccttccagc 3161161 accttgctga cagaaacacc gcgcccgttt atcttcttaa aacgctcgtc ttctaaagaa 3161221 tcaaggctga tcgtaaccct tttcagccca gcctccttga gcctcttagc ataaacaggc 3161281 agcagtgatc cgtttgtcgt catcgcgatg tcacgaatac ccggtatgcg ggccagtttt 3161341 ttgattaatt ccggcatatc ctttctcatg aggggctctc cgccggtcaa gcggattttt 3161401 tcaacgccaa atcttgtgac aaacaatgtc gcaagccgtt ccagctcctc aaatgaaagc 3161461 agctcctctt tctttaaaaa aggataatcc gggccgaata attcggcggg catacagtac 3161521 gtgcatcgga agttgcagcg gtctgtaaca gaaatgcgaa ggtctctcag cggtctgttt 3161581 cttttatcca acatctgacg cgactctgta atcatagcta cagccccttc ctactccctg 3161641 attctctcag ggtgtgtata tacattaaat gatccgtttc tgacaaatcc aatcgctgtg 3161701 atattcaatt cttcagccat ttgaatcgca agctccgtcg gggccgattt ggaaatgaca 3161761 atcgacacgc cgattttggc cgcttttaac aggacctctg atgagattct gccgctgaac 3161821 acaatcagtt tgtcgcgtac ggacatcccg tttagaaggc agtgtccgta tagtttatca 3161881 agtgcgttgt gccgaccgat atctgtgcgc atcaacagaa gcttctctgt gtcgcaaagc 3161941 gccgcattat ggacgcctcc cgtatcctga aacgtcccgc tcccttgctg catgtctttc 3162001 ataagcgcca gacatgcctc aggcgatatc ttgatttggc tgacagccgt cttggctgtt 3162061 ttgacatcct gctgaaaata aaaatgacgg ccctttccgc agcatgagcc gatcacccgt 3162121 ttcgtataat ccttttgatc caatgtctca gggtgaacga ggtcgacata tacaaaaccg 3162181 agactttcat ctattgtaaa ccttttaatt tctttttgaa atcgtataac accctctgat 3162241 gcgagaaatc cgatgacaag ctcttcgata tgctcaggcg tacaaacgag cgtcacaaat 3162301 tcactgccat tcagtatcac tgtcaaaggg aattccgtca ccatccggtc ttctactttg 3162361 cttatttccc cttgttcata gcgccataca tccctgaccg cagttacttt atcgttcaat 3162421 gtctcttccc ctccgcaatg ttcctgcctt tatatttttt cacactcctc ggattttgtc 3162481 gaattctgag acacaaaaag agccctctat ataaagggct tttacaggat gtgatgacgg 3162541 cggtgtttag gcaggacgcc taagcattta gccgccgttc cttttataac acgtgagcac 3162601 caatgtgcat tgacaacgaa cgcggggttt gtcgacacgc tgagacacct ctgtataaag 3162661 gactctatgt ttgattatgc tgattctttt tcagaaccgt aaacagcaca atagctgcga 3162721 tcaaggtgag aatgctgaca aaaaagaagg ctgccagttt tagaagaaca ccaagcaata 3162781 taaatgcaac ggtggctata agaaaaatca ttccgaataa tttcatatgt tcaacccctt 3162841 tttagggtat cattcccgcc caaactgttt ttaaaccaat aaaaaaggcg cctgggggag 3162901 cgcctgatct ttaggttcct tactcagtaa atttttgtgc ttctttttcc caagcctgtt 3162961 cgaactcatc cgcactgttc gctgaaatat attctccgcc gccagcgaca gctgcttgtt 3163021 tcatctcttc attacccttg acatcaaagt tgaagccaat gatgtttaca atcgtatcca 3163081 catttgatgc acggagcttt tcgatttccg ccgcagggtc tccgccgcac gtttcttcac 3163141 cgtcagtgat taaatacacc acgtttttcc cgtctgcgtc aaatgcttca aattcttttc 3163201 ttgtgtctgc aagtgctttg gcaatcggtg tccatccagt cggcttgagc tcactcaatg 3163261 aattgtcaaa cagagaccct tcatatggat gaaggccgta aatggtttcc gtcgtactgc 3163321 acgaaagggc tttaccggac agtttattgt tccctgcatg cccgaaaacg cgaagcataa 3163381 gatttgtatc ctttggaaga agttcggcaa aagattttac tgattttttg gcaatgtcta 3163441 ttttgcgctc tcctcctgtt ttttgaacca tgcttccgct tccgtcaaac aaaacagcta 3163501 catttgtatc agcctgtttc tcagcggcaa aagacgggga ggcaatggaa acagtcaaca 3163561 atccaatgat accggcagcc agcaattttt tcatatgatt acttcctttc tttttcatat 3163621 tttccaacta tatgttggat tcttctttat gctagaatac gaaaatgcaa aaagatatag 3163681 gacatgctgc cttttgtgct gctttcacga tctgtccaaa atcgcttgaa atgccgttca 3163741 tttttagcca tttccgccca gaaagcataa acagcttgtg tgatcattca ttcttttttc 3163801 gccttgatta tgacagaaaa acggaaatct gctactatgc tacaggcaga cagctaatta 3163861 gttttgaagt ttttgttaca tacaaaaaga ggctgaccat caccagcctc ttttttctta 3163921 tttagataac attagtgatt gctgagtgaa aattttctca acatcttttt gggtataagc 3163981 cgggaagtat tcaccgccgc ctactttcgc aattgcgttc agctggcctt tgtatccctc 3164041 tttataatca aagccgatca cattaacagt gatattgtct ttttgcagtt cctttgctgt 3164101 tttaatcggg tttcctccgc acgtttcctc accgtctgtc aacagataca ccactttttc 3164161 cccttttgca tcaagctggt caaaagaaga tttcgcctcg ttcagcgctt tggcaattgg 3164221 cgtccagcca gtcggcccaa ttgtattgag agaattgagg aagctttgct cgttaaagct 3164281 ttggaagccg tatacgttgc gaatggcttc acatgactga acttttccgg aatttttatt 3164341 gtttccttca gagccaaaca cgctcatttt cacctgagtt ccttctggca atgagctcgc 3164401 aaactttgaa atttcttttt tggctgaatt aaatttagat acaccatcta ttcttttcgc 3164461 catacttccg ctggcatcaa gcaagaccgc cacgttcgcc ggcgctttag cctccgtttc 3164521 tgtcttttca gctgcaaaag caggtgaagt taatccaaaa agcaatcctg tcatcatgat 3164581 cagtgaaaat cttttcttca tgttcgtacc cctttaccaa tttgtttctg cgtgcagatg 3164641 ttcaacgctg aacataatct atcgtaatca acaaaaaccg agaaataaat agggcgggct 3164701 tccccattgc tgttgtttac ttttgcatag aaacctatgt ttttattagt gatttccacc 3164761 taacgcccct atgaaaagag aagattgtcc gcctttcggc tttcgttata tgagtctgtc 3164821 gaagtctgtc gacaaatgtg gatgacttta ccacaatctc aaagcctgaa atcaggaaaa 3164881 aaggactgat ccttaaagac ggtcagaagc tcctctaaac cgtttcagct actcttagat 3164941 aaaagatatt caggaacaga aaaagacgcc caatgagcgt ctttttctac tttttcgcca 3165001 tatatttatt caaaaacgca tctgcctcag aaatttgtgt gccttggtaa tagtacttta 3165061 caatgtcatc aaccgttttg ccttctttgg ccataaaatt cgctccgtat tggctcatcc 3165121 ccacaccgtg gccaaatcct ctcgtcgtga ctgtaattgt gtctccattt cgcttccatt 3165181 caaaatcggc ggagttgaga cccaactttt cacgtatgtc tcttcctttc agcgtcttgc 3165241 cgttaatgac ggcagttgcg acctggtggc ccggtgtctc gccggtaatc ttccctactg 3165301 cgctagatcc atccagcttg acgccaagct tttgctgaaa ttctgccgct gtaaaggttt 3165361 tcgttgcctt atatttcgga gactttttat cccatgggct tttgacgctt tttaaatatg 3165421 ggatagcact tgtccaataa gcttctgcat tctctgtgta gccgttgctt gtggagaaaa 3165481 aggatgcttc aatcggctgg ttgttgtacg ttaagatttt gccttgcgta ctggctaccg 3165541 catctgtgat tttcttcagt tttgtctcat agcttgtgcc ccactgtttt ttcagctccg 3165601 ctttgctttt atacacctgg aacatctgtg tatcatccac cagtgagcct ttaggagctt 3165661 ctaccgctga atttgacacc atcagtctga caataaatgt tctggcggca agcgcctggg 3165721 ctttcagcgc ttcaggttta aaggttgccg gcatttcgga ggcgacgact ccaatcacat 3165781 actcttcaag cggaatgttt tctacggatt gatttgcggt tcgatagacg ggaatagaaa 3165841 caggtgatgc tttcaatgtt tctgctcctt tcgatgctgg tttcgtgctg actgctgtct 3165901 tttctgattc tacgctggcc cccgcttcct tattatgctg gaatggtata accaagagtg 3165961 tgggaaccaa gagaatcaat gcacatagta cggatagtgt gattgcgaat tgtttcatat 3166021 tcagctgcct cctgctcggg attcgactct agtctagtct atgggcaggg acaagctaat 3166081 atgactctcg ttttggacag aaactttatt tgtcatttac gtattctttt ttgctatttt 3166141 gcgcataatg atgataatac acaaaaaata aaaaaccagt atgccagagt gacatactga 3166201 ttttcaagta agtttatgca tttaagtcag aaacgacttc tttattctct tgctcagaag 3166261 cagactcatc atttacacgt tcgatgtctg cgcccagagc ggcaagcttc tgatggaaat 3166321 caacgtaacc gcggtctaag tgcttcaatt cagtaacacg tgtgtgacct tcagccacta 3166381 accccgcaag aatcagcgct gcacctgcac gcaaatcagt cgctgcaact tcagctccct 3166441 gaagctgtac aggaccgtta atgatgacag aacgtccttc aatcttgata tcaccattca 3166501 tacggcggaa ttcttccgca tgcataaaac ggttttcaaa aacggtttct gtaatcatgc 3166561 ttgtgccgct tgcacgaagc agaagcgcca tcatttgtga ctgcatatca gtcgggaagc 3166621 ccgggtgagg cattgttttg atgtcaatcg gtttaagctc tttcgggccg atgacacgca 3166681 gaccttcacc ttcatcctta attgttacac ccatctcttc catttttgca attaaagagg 3166741 tgaggtgctc aggaaccgct ccttttacta atacgtttcc ttcagtgatt gcagcagcaa 3166801 ccataaatgt gcccgcttca atacggtcag gaataatatg gtgttttacg ccgtgaagct 3166861 tttcgactcc ttcaattttg atggtgccgg tgccagctcc gcggattttt ccgcccatgc 3166921 cgttgatata gtttgctaaa tcaacgattt cgggttcttt tgccacgttt tccagcgttg 3166981 ttgttccttc agctagagcg gctgccataa tcaggttctc tgtagctcct acacttggga 3167041 agtccagata aatttttgcg ccttgcagtc ggccttttac ttcagcttca atgaagccat 3167101 taccgacttt gatttctgcg cccattgctt caaaaccttt taaatgctga tcaatcggtc 3167161 tggaaccaat tgcgcatccg cccggaagtg caactcttgc atgacctgta cgcgcaagaa 3167221 gcggccccat gacaagcaca gacgcacgca ttttacgaac atattcaaaa ggtgcttcag 3167281 tttgcaaagc gtatgaagca tttacagtca cttcattatt ttcaaaatgc acatctgctc 3167341 ctaaatgacg caacacttcg ttaattgtat atacatcgga gagcgtaggt acatcacaaa 3167401 ttacgctttt ttcttcactt gctaataaag atgcagcgat aacaggtaaa acggcatttt 3167461 tagcgccttc aactttgact gtgccgttta acttctgacc gccgcggacg atgatttttt 3167521 ccaaggtatt cccctccgcg tccctaaatt ctctatatta atattcagtc gtaacgattg 3167581 gtgtgccaac cgtaacggta tgttttccgc ccattcctgc acttctaagt gcaatttgca 3167641 aattcatttt atgtttcgag gtcataatgt actcttccca ctcatctgta aacgcagaaa 3167701 tagaaacgaa atttggctca actacatgtt ctactgatct tgcttgaaat tcatttaata 3167761 actgatttgc ttttttttgc aaaacaatat tcatattatc atctaagtga ccatttagac 3167821 aagtaaaaat aactactttt tcttggaata tcccaagtgt ctcccgttca aactgttcat 3167881 atgtatcatt ccagctatcc ggtgtctcta gactcatttg ctcatataat aaatacgaag 3167941 ttggattgtg ttttttgagg gttgtgacaa gctgcagtct aaaagaagta cgattttttt 3168001 tgtcagtata tgtgccaatt gcctttatca ttttatcttc ccgtgcaatc acccaatcat 3168061 attgacgata ctcttgtttt aaacgttgca ctttttgata aaattctttt tcggtcagtg 3168121 acaagttttg ttttgcatgc aatgtccact tatctattga cacatcttga cgttccatcc 3168181 cctctgccat ctgtgctaac ggcgttaatt cactcgcatg aatggtatgg aaaacagcaa 3168241 tgacgaagct taacatgacg gaaatgataa tagcgtggct tacttgtttt ttcttcatgt 3168301 tcatctctcc cccttatccc cagttttacc ggaggcaaga ggcgccatac gtaaaaatct 3168361 tcgtcaaaac tcgagctatt cgcttcaacc cgcttctccc aaccatttaa taatgttcaa 3168421 aacctattaa aatagatagg gaagctgctg tgaataattg aggtaatcta aaaagaaatt 3168481 ggcaacggcc gttccaatgg cgattgtcag caaaatcatc aggagtcttg cctgcacgac 3168541 tttgcctttt ttgattaacg gatctatatt gacggcttgc aacgcccacc aagtcactgc 3168601 tataaaaatc aggtgaacga caatgccgat tgcagcctgc tgtcccaata cactcatcta 3168661 ttacactcct ttctctgcgt tcataccctt tcttattata taagaagcac agataaagat 3168721 gatacatttt atacagaacg gaataatcag ccaaatctag ggctaatccc cgcttaaagt 3168781 gcgattcttt tacatggtat actttattgg aaaggagctg gcaaatgtga atcattcttt 3168841 ttttcagcct gaaaagcaat atggtgagga cctgccaatt tttgatcagg aatgggaagc 3168901 aattgcattc tattatgatt atagacagtc acagattgaa gaactgaatg aattgtgtca 3168961 gttttttaac atttctctta cctatacgag agaaagcctt gaagagcttg aaaacctcta 3169021 ttttcaaagt atacaagaac ttttgcttgc tgattggaat cttcctattg aagaattcga 3169081 gaaaatgatc agtgtttatc ttatagattg tgtgattgcc cgccatgaag atgctgaatg 3169141 ggttgtaaaa ccttatccct ataaagacgg cgcttataca cttggcttta gaagacatcg 3169201 caaatcgtgg catacaatga atgcctgtga tggtttatac ctgcgtccaa aagaggatcg 3169261 cccgttgctg tcgctgtttg attctcttgt gcgttcataa aaaaatcctt ctcataaaga 3169321 gaaggatttt ttcttatttc cctgctacat ccaatctgtt caaagcccgc tgtaacgcaa 3169381 gctcagcccg acgaatgtca gtatcatctg attgagaatt caaacgctcc tgcgcccgct 3169441 ggcgtgcagc ttcagcgcgc tctttatcga tgccttccgc tgtctcggca gcctgggcaa 3169501 ggatggtgac atgatcagga cggacttcta caaaaccgcc gctgacggca accatttcag 3169561 tctgcccgtc ttttttcaga cggacagcgc cgattttaag aggagccacg gttggaatat 3169621 ggcctggcaa aataccgaga tcgccgcttt cggctctcac actcaccatt tcgatatccg 3169681 catcgtatac tgggccgtcg ggagtaacga tattgacttt aacggtcttc atgcttttac 3169741 cctcctagga ccagattaaa cttctacacc catttctttt gctttctcaa caacttcttc 3169801 gatacggcct acaagacgga atgcatcttc tggaagatgg tcatatttac cggctaagat 3169861 ttctttgaag ccttgtaccg tctcttttac aggcacgtaa gaaccttttt gtccagtgaa 3169921 ctgttcagcc acgtggaagt tctgagaaag gaagaactgg atacgacgtg cgcggtgaac 3169981 gacaagtttg tcttcctcgc ctaattcatc cataccgaga atcgcaatga tatcctgaag 3170041 ctctttgtaa cgctgaagcg ttgactgtac ttcacgcgca accgcatagt gctcttctcc 3170101 aacaatttca ggagcaaggg cgcgtgatgt agatgccaac ggatcaaccg cagggtaaat 3170161 acccatttca gttaatttac gctcaaggtt tgttgtcgca tccaagtgag cgaacgttgt 3170221 cgccggcgcc gggtcagtgt agtcatcggc aggcacgtag atcgcctgga tagatgtaac 3170281 tgatccaacg ttcgtagacg tgatacgctc ttggagctga cccatctcag ttgcaagcgt 3170341 cggctgataa ccaaccgctg aaggcatacg gccaagaagg gctgaaacct ctgaacccgc 3170401 ttgtgtgaaa cggaaaatgt tatcgatgaa gaacagtacg tcctgtcctt gtacatcacg 3170461 gaagtgctca gccattgtaa ggcctgtcaa agcaacacgc atacgtgcgc ccggcggctc 3170521 gttcatttgt ccgaatacca tggctgtttt gttgattacg ccagagtcac tcatttcgta 3170581 gaaaaggtcg ttcccttcac gagtacgctc tcctacgccg gcgaatacag agataccgcc 3170641 gtgctcttgc gcgatgttgt tgattaattc ctggattaat acggttttac ctacaccggc 3170701 accaccgaac aatccgattt taccgccctt aatgtaagga gcaagcaaat caacaacttt 3170761 aatacctgtt tcaagaattt caacttctgt tgaaagctga tcgaatgaag gcgcctgtct 3170821 gtgaatcgga tcctttttcg catccgcagg aaccggctca ttcaaatcaa tattttctcc 3170881 gagaacgtta aatacacgtc caagtgttac atcaccaacc ggtactgaga ttggcgctcc 3170941 tgtatctaca gcttccatac cgcgctgaac accatctgta gatgccattg cgattgtacg 3171001 gactgtatca tcacctaaat gaagagcgac ctcaagcgtt aaatcaatac ctacttcgtt 3171061 ttcacttgca gctggctgtg aaattttaat cgcattataa atttcaggca agtgaccgtc 3171121 ttcaaaacgc acgtcgacga ccggtcctaa tacctggcta acgcgtcctt tcttcatcgc 3171181 tatccctcct gacaaaatct ttctattcta aagcggctgc tccgccgaca atttccgtaa 3171241 tttcttgtgt gatggctgct tggcgagcgc ggttgtaaga aagcgaaagt gaatcgataa 3171301 gttccttcgc gttgtctgtc gcgtttttca tcgccgtcat tcttgcagcg tgctcacttg 3171361 ctttactgtc aagaagcgca ccgaagatta agctttctgc atattgagga agcaaaacct 3171421 ccagaacctc ctcttcagat ggttcaaatt cataagacgc cgttcttttt ccgccgccgc 3171481 tgcccaaatc agataacggc agaagttttt tctccgttac ttcttgagta atggcgctga 3171541 caaaatggtt ataaacaagg tgcaattcat caaacgcacc gtctataaac atttgaatcg 3171601 tttgacgggc aagatcttta atttctgtaa acgttacttc atctccaagt cctgttaact 3171661 cggaaatgat cggaatctcc cgtttcttaa agaaatcacg gcccactctt ccgatggcaa 3171721 tcaccgcata ctcatcctta gactgatgac gttcttgcat ggcctgataa gcactccgta 3171781 aaaccgaact gttaaaagcg ccggcaagac cgcggtcaga cgtaatgaca aggtatgccg 3171841 tttttttcac ttctctgctg agaagcatcg ggtgcttcac gttgccggaa actcttccga 3171901 cgtttgacac aacctcttgg attttatcca tatatggcac aaatgatttt gcattgtttt 3171961 cagcacgatt cagcttagcc gcagatacca tctgcatggc ttttgtaatc tgacttgttt 3172021 ttttcgttga cgtgatcctt gacttaatat cgcgtaatga ggccaaagat ttcaccacct 3172081 tttctcttca tctgcgtaaa aagagagaaa aagagaacct ttttctctca tcagcattcg 3172141 agttagttgc ttggtgcaaa tgtgcgtttg aagccttcga ttgcagcttt gaagtcttca 3172201 tcagcaggaa ggtttcctgt tttcgcaatt ccgtcaagca ggtctttatg gttttggtca 3172261 aggtacatgt agtactcttc ttcaaaacgt ctgatatccg ccacaggaat atcatcgaga 3172321 tatccttttg tcagcgcata aagaatagct acttgctttt caaccggaag cggcttgttc 3172381 agatcctgct tcagcacttc aactgtacgc gcaccgcggt tcagttttgc ctgagtcgct 3172441 tggtcgaggt cagaaccgaa ttgagcgaat gcttccagct cacggtatga cgcaaggtca 3172501 agacgcaaag tacctgatac ttttttcatc gctttgattt gcgctgagcc gccgacacgg 3172561 gatacagaca atccggcatt gatcgctgga cgtacgcctg agaagaacaa atcagattgc 3172621 aggaagatct gtccgtcggt gatggaaatg acgttcgtcg gaatataagc agagatatct 3172681 ccggcttgtg tttctacgaa cggcagagct gtaattgatc ctgcgccttt cgcgtcgcta 3172741 agctttgctg cacgctcaag cagacgggaa tgaagataga atacatcccc agggaacgct 3172801 tcacggcctg gcggacggcg aagaagcaag gacagctcac ggtaagcggc cgcttgttta 3172861 gaaagatcat cgtatacaac aagaacgtgc ttgccgttgt acataaattc ttctgccatt 3172921 gtaaccccag catacggtgc caggtacaga agcggtgccg gctgtgacgc agacgccgtt 3172981 acaacaattg tataatcaag cgcgccgtgt ttacgcaatg tttctactac gccgcggact 3173041 gttgattctt tttggccgat cgcaacatat acacagatca tgtcttggtc tttttggttc 3173101 aggatcgcat cgatcgcaac agatgtttta cctgtttgac ggtcaccgat gatcagctca 3173161 cgctggccgc ggccgattgg aatcagtgca tcgatcgctt tgataccggt ttgaagcggt 3173221 tcatgaacgg atttacggtc cataacgcct ggtgcagggc tttcgatcgg acgagttttg 3173281 cttgtcagaa tcgggcctag tccgtcaacc ggctggccta gcgggtttac aatacggccg 3173341 attaactctt caccaacagg aacctccatg atgcggcctg ttctttttac ttcgtctccc 3173401 tcacggatct cactgaaagg tcctaagatg acgataccta cgtttgattc ctcaaggttt 3173461 tgagccatac ccaaaacacc gtttgaaaat tcgacaagtt caccggccat acagttgtca 3173521 aggccgtgca cacgtgcaat accgtcaccg acttggatga ctgtacctac gtcttgaact 3173581 tcaatatcag attgataatt ttgtatttgc tgttttatca gcgtgctaat ctcttcagct 3173641 ttgatgctca cttaggtttc accccttcta tcgattttcc ccggctaatt gacgttcaat 3173701 gcgctgaagc ttcccgctta cgctgccgtc ataaatccgg tttccaatgc ggactttaat 3173761 accgcctatt aaatccgtct gcacttcatt tctgattctc agtgaagcga ctccggcttt 3173821 ttttgcaaac acttgtgata atggtaacat ttctgcatcc gtcagcggtt tcactgaata 3173881 tacgattgcg tcttctgttt gacgggccac atttgcgagt ttgataaact catctgtgag 3173941 ctcagggaca atcgcggcac gatggcggtc aatcaaaaga aaaatcgtat tgagtacgga 3174001 ctgtgacaaa gagccaaatg cattttgaat cagctctttt ttcttcgcag ccggcacctt 3174061 cggatggttc aacacatcat taagcgcttt ttcattttga aatacttgtt ttacaacaat 3174121 tagctcttct tctacttgat tcagctgagc ggactcattg gctatatcaa aaagagctga 3174181 tgcatatcgt ttagagacag ctgatccact catcggcttt ctcctacctc tttaagatag 3174241 tcctggatca atttctcttg cgcttgttca tccagttctt tttcgatcac tttcgacgca 3174301 atcatgacag aaagagacgc tacttgctca cggagagcag aaaccgcctg ttccttttcc 3174361 ttcacgattt cagttcttgc tgcttctttc agacgttcag attctgcacg tgcagcctga 3174421 ataatctctt ctttttgctt ctctcccagt ttctttgcgt tttcgataag agtttgggat 3174481 tcctgtcttg cttcttttaa aagaacgcgc tgctcttcaa tcagctgctg cgcttcttta 3174541 tttttttctt cagcagacgt aatttctcca gcgatgtggt cttcacgctg tttcattatg 3174601 tttaatagcg gccctaaagc gtatttcttc agaagcgcta ataagattaa catagctaac 3174661 agttggaaca ggatatctcc gccgttaaac gacaatccta gttcaagtgg taattgagac 3174721 atctactacg gcaactccct tctgcaggtt tttctttgct gatccagcag ccgcacttgt 3174781 ctcttttcag ccggcaaggc gggatgctta tcagacataa agcaatggcg aaggttctct 3174841 tggaatgatc ttcgccattt ttagttcata taaggctttt atgcttagcc aaagaacgct 3174901 aagaatgcga taacgacagc gataatagga agggcttcaa ctaatgcgat acccatgaac 3174961 ataagagttc tcagttcttt acctgcttcc ggctgacggg caatcccctc taccgtacgt 3175021 gaaacaatca aaccgttacc aatacctgca ccaagtgcgc ctaaaccaat tgcaatcgca 3175081 gctgctatta aattcatgaa aaagttcctc ctttaaaatg ttatccgttt ggatataatg 3175141 ttttaatgat catgactgat tttatgagac atgtacacca tcgtcagcat tgtaaagata 3175201 aatgcctgga tagcaccaat aaataaactg aatgcttgcc atgccagcat cggcagaatg 3175261 gcaccgattg taccgacaag accgagagcc acgctttgcg aataatggct tgttgctaat 3175321 cccgcaagca ggccgagaag aatctcaccg gcgaagatgt taccatacag ccgcaaacct 3175381 agagtcagcg tattcgcaaa ctcttcgatg attttcatcg ggagcatgaa tggaacaggt 3175441 cttaaatagt ctttggaata ttccttgagc cctttcatct tcacaccata gtagtgggtt 3175501 aaagcaacaa ccatcacggc tagcgttaat gtaatggcag gatcggctgt cggagacttc 3175561 caccagagct catgtccgat tgtaatagag aacggcagcc ccagcatatt cgacacaaat 3175621 atgtacatca gcaatgtgac accaagtgcc aagaagttag cccctgtttt taaatccatt 3175681 gtactgccaa taatattgcg gacgaaatca acaatccatt ccataaagtt ctgggctttt 3175741 ccgggacgga tcgaaagcgt tcttgtcgtc aatatagcaa tcaataaaac aatcacactc 3175801 gccacagtaa tcatcagaat gtttgtcaga ttaaaagtaa gacctagaaa ttctatagtt 3175861 ctgtaaccat gattcaaagg gttttcacct ctcttccatt gatgaacgtt taagctggat 3175921 aaaggaatct atcataatga cagggtatat tgtcattaat ccaataactg tacttgccat 3175981 atgaaagtat tcgggatttt tataggcaac agccacagca agaatcgcat tgcaccaccg 3176041 cgctgcgctc ccgagagatc gtatggactt tcctttctct acagctctgt caaaagcatt 3176101 cattcttctg acgagcagta aaaaattaaa caaactgaaa acagttccca gaataaggcc 3176161 taaaaaaacg gttttatacg ctgttaaacc ataacccagt acatacactg ccaaaatgaa 3176221 caataaatat ttgcgttgtc tgctaaatgt aagcttggga tcgtccatca attatctgtc 3176281 tcctgatgaa aaaataatgt atagcttgga tacggcaaaa atcagcggtt aacccttagt 3176341 agaagacctt ttttgaccgg caaaacgggc ctgttcgaaa aaatcattca tccgcaagcc 3176401 ttgcagggat gctgtttcat tcgcttaaat aaatcctcat aatacgggtt tgctgagagg 3176461 atttacattg aggatgagga ctataatgaa agctatgaaa accttctcat aataccctcg 3176521 tttagcatac aatagcccct aacatgtgtc aatctgttta aagttaaaaa actttttata 3176581 ctttacgtct ccacagaatg ttcacatttt cacctataat tgtatacaga ttcaccgaat 3176641 agcaaaaaac tggataaaaa aatgaaaccc ccttttgggg atttcatttt ttattttgtt 3176701 ccaaacatgc ggtcacccgc atctccgaga cctggaacaa tatatccttt ttcatttaat 3176761 ttttcatcta gcgccgcaat gtaaatatca acgtccgaat gatgcttctg caattcttcc 3176821 acaccctccg gcgctgctac aagacacatg aaacggatat ttttcgcacc gcgtttttta 3176881 aggctgtgaa tggcttcaac tgcggaaccg cctgtagcga gcatcgggtc aaccacgatg 3176941 aattcacgct cttccacatc agaaggaagc ttgacatagt attccacggg ttttaaggtt 3177001 tctggatcac ggtaaaggcc gacatgtccc acttttgccg caggaatcag ctttaaaatg 3177061 ccgtcaacca ttcccaatcc tgctctgagg ataggaacca ctccgagttt tttccctgag 3177121 atgactttcg atttcgcagc ctgaaccggt gtattgatat ccacttcttc cagaggaaga 3177181 tcgcgggtaa tttcaaatgc catgagtgta gccacttcat ctactaactc tctaaaatcc 3177241 ttcgtacctg tattttcatt ccgtatatat gtcagcttgt gctgaattaa aggatgatca 3177301 aatacataaa cctttcccat actgtgtttc agctcctttt ttattgtccc atcaacaatt 3177361 acacacttct attgattcta caaaaaaaga cattgagttt caagaacatc gtcaaaaaac 3177421 ccgccgggca taagcccaag cgggttttag gatcttaata atctaattct ttatataaag 3177481 gaaatttatc agtcagagca gctacacgct gtcttgcttc ttcaagtttt ccttcatctt 3177541 cgtggttttt caatgcaagc gcaatgatag caccgacttc ttctaatgcg tctccgtcaa 3177601 aaccgcggct ggttacagca gctgtaccaa gacggatgcc gcttgttacg aaaggttttt 3177661 caggatcata tggaatcgcg tttttgttag acgtaatacc aatttcatca agtacatgct 3177721 ccgcaacctt accagtcagt ccgagcgaac gaaggtcaac aaggataagg tggttgtctg 3177781 ttccgcctga aacgagctgg atgccctctt tcgttaaggc ttcagccaga cgtttcgcgt 3177841 ttgaaatgac gttttgtgca tatgttttga aatcgtcctg caatacttca ccgaatgaaa 3177901 cagcttttgc ggcaataacg tgcatcagag ggccgccttg aattccaggg aagatcgatt 3177961 tatcaatttt cttgccaaac tcttcacggc aaaggatcat accgccgcga ggaccgcgaa 3178021 gtgttttatg tgttgttgtt gtaacgaaat cagcgtaagg aaccgggttt ggatgaaggc 3178081 ctgccgcaac aagtcctgcg atatgtgcca tatccaccat gaagtaagcg ccgacttcat 3178141 cagcaatttc acggaatttc ttaaagtcga ttgtacgagg atacgcactt gctcctgcta 3178201 cgataagctt cggtttatga gcgagggctt tttcacgcac gtcatcgtaa tcaatatatt 3178261 gagtttcttt atctacgccg tactcaacaa agttatattg aacaccgctg aagttgactg 3178321 ggcttccgtg tgttaaatgg ccgccgtggg agaggttcat cccaagtaca gtatcgcctt 3178381 gctccaaaat cgtgaagtac actgccatgt ttgcttgtgc gcctgaatga ggctgaacgt 3178441 ttacatgctc cgctccaaag atttccttcg cgcggtcacg ggcgatatct tcaacgacat 3178501 cgacgtgctc gcatccgccg tagtagcgtt tgcccggata tccttctgcg tacttatttg 3178561 tcaaaacaga tccttgtgct tccataaccg cttcacttac aaagttctca gaagcaatca 3178621 attcgatctt agtctgttgg cgttcacgct catttttaat ggcgttaaac acttgttcgt 3178681 cttgcgcagg taaatgtttc atcagcgaga tcctctccta tccgtatcct gttctttgtt 3178741 tttaccatca ctattgtaca tggtttttaa ggccgatgta aaagattatt tttaaaaaat 3178801 ctaaattttt attggtaaaa acgaatatta ataacttaaa tttaatttaa agttcggaat 3178861 ttatttcact atcttaaaat aaaagaaaag actggctatg cagtcctttc attcgcactc 3178921 ataaaccgcc cgcactccgc cgattagttt cggccgtgta cgcgccaatg tcacatgagc 3178981 tgaaccgagg ctgttttgag agacacgcac agggacagcc accggtttca gatgcatgcc 3179041 gataaacgta tcgcctatat caattccggc gtcagcctga atggtttcaa caagaacagg 3179101 agacttcatc tgcttaaacg cataagacgc catcgctccg cccgcttttg gaacgggcac 3179161 ggcagaaacg gttggaagcc tgaacagctt ggctgtttct gcttcgacga caagcgctct 3179221 gtttaaatgc tcgcagcatt gaaacgccag atggattccc gttttttccc ggagctcagc 3179281 aagtccgctg tagatgcttt cagcgatatc tacactgccc gatgtgccga tccggctgcc 3179341 ggccacttcg ctcgtgctgc atccaaggac gaagagctga tcttgtttca attccgcttg 3179401 gtcctgaaac tcagacagca tcgtcttcca cgtttgtttc aactcattca ttaaacagca 3179461 cccctacagg tttttctctt cataatcgga gatttttcca atacgcgttt ggtgtcttcc 3179521 cccggtaaac tcagtagtca gccagatttt tgcgatttcc cgagccaaac caggtccgat 3179581 cacccgttca cccatcgcaa ggatgtttgt gtcattatgc tccctcgtcg ccttcgcgct 3179641 gaaggtatcg tgcgccagcg cgcagcgaat cccttttact ttattagcgg aaatgctcat 3179701 gccgatgcct gtcccgcaaa ttaaaatgcc tctgtcaact tcgccgctaa ccactttttc 3179761 ggccaccgga aaagcataat ccggataatc gacagagccg ctgccgcagt cacagcccat 3179821 atcaatatat tcaatttgca attcgtccat taactctttg atttcatttc gaatgtgaac 3179881 gccgccatga tccgatgcaa tggctacttt catctgcttt tcctcccagc gtgtgtgatg 3179941 cggcccgccc gctttattga ccgcgcagcc tgtccgctct ttgattcaca ccatatgatg 3180001 tgcttttcac tatattctac tccttcacgc aggatttgca aatgacctgt ttgcagattt 3180061 tctgacaact tatctacggt cttttttcag ctgttttgcc agctgccgaa gaagctcttc 3180121 aagctcatct cgcgtttgtt tatagatgtc aattgagccg ccgaacggat cgaggacatc 3180181 accatggctg cctgtgacat attcttttaa cgtaaacact ttatcacgat aacgtccaaa 3180241 ttggctggca atgatctgtt tgtgctgatg ggtcatagcc agaaccaaat cagccgattc 3180301 cataagttct tcagttaatg gagaagacac atgattaagg gcaatgtgtt tttcaaacag 3180361 cgcttcgact gcatgaggcg tcgctttccc attaggtgaa gcaaacacgc ctgccgagcg 3180421 gacattgaca ttcagccctt ccctttctgc aattgattta aaaagcgcct cagccattgg 3180481 gctgcggcac gtatttccag tacagacaaa aataatatcc atgtcagtca ccccttattt 3180541 ttctctatta tatatgaaga aaaaagaaac ggcgacttcg tttcttttat tggtatatta 3180601 aattggcaaa agcagcttta atccaaacac gattaatatg atgcccccga gcgcttcgct 3180661 gtatgtgcca agccatgact gcacttgttt tccgaccagc aggcccagcc atgtcaacat 3180721 catgctgaac agcccgaaca gggtaattgt gaggagcgga tgcgagccgt atatccccaa 3180781 gctcaagccg acggaaaagc tgtcaaggct gacgccgatg gcaaacagca ataagcccgg 3180841 ccctgccggt gacatgaatc gttcttctga ctgtttaaaa gaggccataa gcatttgaac 3180901 cccaagaaca aaaagcagcg ccccaccgat ataaaccgct aacacgccga ggagccctga 3180961 cagcatgtta ccggccgcca tccctgcgag aggcatgatg acgtgaaaga ggccgatgat 3181021 gaaaccaata tagaatatct gcttctttct aagtttgacc atgcccattc caaggccgac 3181081 agaaaaagca tccatcccta aagcaaacgc catgatgctt aatgtaatca gttcgcctat 3181141 aaacaaatcc gacatacata aataaccccc ttggacacgc cccgcttttt tagcctatgc 3181201 gtgtccaaaa agggttagaa catctgactg ctttcagcga atcactcttc ctccggcggc 3181261 tttcatcagc ctgttcataa tagcaagacc gacacctgta tccggaaagg attccgctat 3181321 aatgaaatcc accttattct catcaaagct gcgcaaagca tcatacagcc ctgccgcaac 3181381 agtctcaagc tgagcccgtc ttccgcagct cttcacataa tcagcggaat aaacgcccgc 3181441 tttttcttct gtcgtcagga caccgacccg tcttccaccc tgttgatatt cttgaatgag 3181501 gtgctgaatg cgctctgggc tgccttcgca aatggcaaga ggcgctgtcg gcgcataatg 3181561 tgtatatttc atccctggag aaatcggctt ctcgttttgg tcgctgagcc ctttatccac 3181621 atggatcggc ccgatcaccg cttcaatttg ttccttcgta atgccgccag gacgcaagag 3181681 aacagggatg tcgtccgcac atgaaagcac agttgattcg accccgattc cggtagggcc 3181741 tccatccaca ataccggcta tgcggccatc caagtcgtga gccacatgct ccgcttttgt 3181801 gggacttggc ttgcctgata gattggcgct cggtgctgca atcggcagtc ccgattcgcg 3181861 aatcaatgca agggcaagcg gatgatccgg cattctaatg gcaaccgttt caagacctgc 3181921 cgttacacga ggtgaaagcg catcaggttt gcaaggcaga atgagcgtaa gtgctcccgg 3181981 ccaaaaccgt ttcatcaatg ttttcgcctt ttccggcgcc gggcccgtta aatcctcaag 3182041 ctggctgata tccgcaatgt ggacaatcag gggattatcg ctcggccgcc ctttcgcctc 3182101 atatattttt ttgacggcat ccgtattttt tgcgtttgcg cctaggccat atactgtttc 3182161 tgtcggaaag gcaacgacct cattttctcg gagcaaagcg gctgcttgtg caatttgtgg 3182221 atcatttgtg gataactcgt cagttacatc cacaaaccat cttttcgttt tcatttctga 3182281 ccaaactcct tattcacaac aataaaacga ttgttttacg cgtgtaatcc ttttgaaagt 3182341 ataaaagatg tcctgtaata aaacaagcgt tatccacaaa ttgtggacaa cgctaataaa 3182401 gaagtggata agtatgtgta taaactgcac ttatccagac gcttttttca tcaaaacggc 3182461 tccttctgtt tgccgcgatt cacagaagtg atcagaagaa aacagctcct ccggtacact 3182521 ctcagctctt tcaaaaccca tggccgtcag aaagtccgca gaggaatgct gatttgctac 3182581 taggtacacg gttttgatct gatgcttttc gcacagcacc tccatgcttt gaaaaagcgt 3182641 gacgatgtgg ccttggtgaa gcttgtccga tatgacaagt gatcgcagca gcccctggtc 3182701 acagcttatt ttttcaatac cgaggcatcc ggcaatgttt ttctcactgt cctccagcat 3182761 aagaaattga gtgaagcctt ctttcacgcc ttcatagctg gtttttgcct gttttaaaaa 3182821 tgcctcgagc acatctccgt ctttttccct tgccacccgc agttgataaa acatccgttc 3182881 accccgtttt tgcgttcttt cttccaatct atgaggcaaa tctattttta gaccagatga 3182941 ttaggaaaaa aggtcggaaa tccattcgac taaaaagaat ttcacttctg tgccgtcttc 3183001 tttttcttcg ttctcttctt ttttggcttt ttccgcttta gcggttacgt cctcaagcac 3183061 tttttcagtc tgcttttttg aggcttcttt atcttcttgt tctttgacgg cttccccgtt 3183121 agaaaaatca agaaagcaga ggggcgggaa cagcacacac caccagttgg cgccgtctcc 3183181 gtttccaagc gtaatcaaaa tcgcttcata ctcaccagcg ggatatacca tgttgccgta 3183241 aagctttgtc ggaaacgaga ttttgtcaaa atcaacggat atcgactgat tcgctccttc 3183301 tttctccatt gtttcctttg caattgcttt gatttcaggc agctttgaac gaatcacgcg 3183361 acgcgcttct tcaatagaag taatatcctt tacccaagtt gtgatttctt tattcaccgc 3183421 gtctcttata tgacgtttta attgctggtc ttgatcacta tcgctgtttg ccagtattct 3183481 caaacgaatc gcctgatcag gtatgaccac cggctgattt tccgattttt gtgccgtctc 3183541 ttcttttgcc agccctacga gcgctccgga taataaaaga aagatatata tacaaatgat 3183601 tactgttttt ttcatcggtc cccaccgttc ctctccgtgc tttgtttcta gccctattat 3183661 ggacaaggag agcctgggat aaacgtgcag ggtgaaaaaa atctagcaag ctgttaatct 3183721 tatttatggt acgatagtgt tttaggaggt ttaagatgaa atacaattat acagtgctgt 3183781 tatcagcatt cacgatgtcc gttctttatt cagtaattta tattcattca tttatcattg 3183841 ccgctctcat cacaatggca ttttattttc tgtttcctta tttgatcttc gcactgccgc 3183901 ttcaaatcat gatgaataaa aagccgaaac gtttcagccc tttgtatctg ctgtattacc 3183961 ttgccgctgc ttttattgcc aacgcgatca ttttcggcat gcttcagcct tcgggacaat 3184021 ctctgtttca aaatacagcc ttttatcttt tcgctgtatt aacagctctt atctattgga 3184081 tatgggattc tgttttactg caaaaaaagg aagcctaaga ggcttccttt tttattaaaa 3184141 caaaatcgtc agtaaataac atagaatgga aggtatcgcc gcaacaaaga aagcggccgc 3184201 cattttcatg cgagatgtac ggccttcttt ggtttctgaa tggtagtttg cccgctgatc 3184261 gcttccgctt acagccaaac ccgatgtaat gatcgcgagc cccactaaaa cgagagacgc 3184321 aacgccaaaa atcgcttcat atgaaagagc ctgcggaaaa atggtgccaa tcatgctctc 3184381 aatcgcaatg agcaggattc ctgctgtcag ggcctttttc atgtttacat cccctttgct 3184441 ggtgttaaac agcttgatcc attcactcgc cagcaagctg cttatttatt tttatgaatc 3184501 agagcgcata tggttctgtc ttttccatta atatctttca gcacttccac ttccgccccc 3184561 ttaaacgcct tgaggatcag gtctttgacc gccgctccct gtttccagcc gatttcaaaa 3184621 acgacaaata ctttatcctt cataacaagc ggaatgtctt ccataaaccg cttataaaat 3184681 ttcagcccgt ctccgccatc ggtgagtgcg tgcagcggct catgaaaacg gacaatttcc 3184741 gataaatcag ccatttcttc ctctgaaata tatggcgggt ttgagacaat gatatccgct 3184801 ttttttcccg ccttaataaa aggctcaagc agatcgccct gataaaagcg cacattcgct 3184861 ccgagttttt ctgcattggc agaggcgact tgcagcgcct ctttcgaaat atcgaccgcc 3184921 gacacagaaa agctttggtt ttcaagcgca agcgtgacgg ctattgcgcc gctccctgta 3184981 ccaacgtcaa caacttcgag cttgccgtct tcagaaaaaa cactccgata tttttcaagc 3185041 aaatgaaaga caacttcttc agtttccggc cgcgggatca gcacatcatc attcaccata 3185101 aattcccgtc cataaaaaaa ctcttttcct ataatgtatt gaaccggcac gccctcttta 3185161 tgcatctcaa cgtgacgctt aaagcgatac agttcgtctt caccaatcgg ttcctgtaag 3185221 cttgcgagca gcttgcttct ctccattccg gtatcataaa gcaataggag ctcggccgca 3185281 ttttcttctc ttcccgcttc ggttaaataa gaagaagccc atttcagggc ttcgaatatc 3185341 gtcttcatct taaccttccg actgctgaag cttgcttgcc tgatcttcaa caatcagcgc 3185401 ttcaaccact tcgtcaagtt ttccttcaag aatctgatca agcttttgaa tcgtcaaacc 3185461 gattctgtga tccgtcacac ggttttgcgg gaagttgtat gtgcggatac gttcagagcg 3185521 gtcaccagat ccgactgctg atttccgtgt ttgatcatat tcagcctggg cttcctgctg 3185581 aaatttatca tagattctgg cacggagaac cttcattgct ttttctttgt tcttaatttg 3185641 agatttttca tcctggcatg atacaacaac acctgtcggc aagtgagtca gacgaaccgc 3185701 agacattgtt gtgttaacgc tttgtccgcc cggtccgctt gaagcaaatg tatcgacacg 3185761 gatatccttc tcatggatgt cgacctctac ctcttctgcc tcaggaagac atgccactgt 3185821 tgcagtggat gtatggatgc gtccgcctga ttctgtttcc ggaacacgct gtacgcggtg 3185881 ggcgccgttt tcatatttga gtttagaata cgcgccgctt cctgtaatca taaagatgat 3185941 ctctttgtag ccgcccgttc cggttacatt cgcttccatg acctctgttt tccagccctg 3186001 aagctcagca taacgggaat acattctgta cagattgccc gcgaataaag cggcttcctc 3186061 gcctcccgca gccccgcgga tctccatgat aacgtttttg tcgtcattag gatctttcgg 3186121 gatcaggagc accttcagcc gttctgacag tgtttccgtt tccttctgaa gttcagaaat 3186181 ctcttccttc accatgtcgc gcatctcagc atccagcttc tcttcaagca tcgcttttgc 3186241 atcagccagc tgttctgacg catctctgta ttgtctatat acgtcaactg tttcttgtat 3186301 atcagattgc tcttttgaat attctcttag ctttttcgga tcgttgacta cttctggatc 3186361 gctcaaaagc tcatttaatt tctcgtatcg ttcttcaatt gattttaaac ggtctaacac 3186421 ggtcttcacc tctgttttcc tgtgcgtaac attctcatta tagtatagtg attaacccca 3186481 gtcaaaagca tttcaatccc agctggaaaa gctccctctg ctatactgga attcgaggag 3186541 ggatgatgtt gctgaaatcc atacatcata ttgcaatcat atgttcagat tacgaaaagt 3186601 cgaaagcttt ctacgtacat aagcttggtt ttcaggtgat tcaagaaacg taccgcgaag 3186661 agcgcggctc ctataagctt gatttgtcgc ttaacggctc gtatgtcatt gagctgttct 3186721 cgtttcccga tccgcccgaa cgacaaaccc ggcctgaagc cgcaggcctg cgccacctcg 3186781 cctttacagt cggcagcttg gataaagctg ttcaagagct tcatgaaaaa ggaatcgaaa 3186841 cagagccaat cagaacagat ccgctgaccg gcaagcgttt caccttcttt tttgatcctg 3186901 accagcttcc attagaactg tatgaacaat aacagttttt gaagaaaaaa aggagatacc 3186961 cactttcttt gccgaatctt ttcttgtttt gtctaacggg aagggaaccg cattctatgg 3187021 tcgaatacct agcttaaaag gaggtatggg atcatgaata caaatatggt agcaagtgaa 3187081 ctcggcgtct ccgcaaagac ggtgcagcgg tgggtgaagc agctgaatct tccggccgaa 3187141 cgcaatgagc tcggacacta ttcgttcacg gcagaagacg tgaaggttct aaaatccgtt 3187201 caaaaacaaa tctctgaagg cacggcgatt caggatattc atctgccgaa aagcgctaaa 3187261 aagcgcacag gcttccttgt ccaaaaaaca agtagcgaca cagaacgaag aatcgagcag 3187321 cttgaacaaa agctggacac ccttttacag caaaggcagg acgaaagcga attgatggca 3187381 aggatgtcgg aactggaacg ccagctgaaa caaaaagccg atgaaggtgt atcttaccag 3187441 ctgcttcagc accgcagaga aatcgatgat attcttgcag atctgcaatc actgacctca 3187501 caaatgaaag aattcaccgc tcattcgatc cccgagactg ctgctgcttc tgaaaaaacc 3187561 aaaacaagaa aaaaaccgct gctgtcactg ttcaaatttc aaacctaaag caaaaagctc 3187621 ccttaaaggg agcttttttt gttacgcagt aagcgcgata atgattggaa gtgaaatcaa 3187681 tgacagaatc gcactgacca caaacgcagt tgcagtttct tcttcttgtt tctcgaaacg 3187741 agtcgcaatc atggctgcaa cggcagaacc agggaatgca acaagaagga ttgcttttgt 3187801 tgtttggtca gctggaagtc cgatagcaag agcaatcagg aacattaacg caggctgaac 3187861 cgcaactttt agtaacgcaa taccgatagc cggcatactg agtttaattt tacgaatacc 3187921 aacggtaaca ccaacagcga agagagcaac accagatgtt gtgcttccaa gctgatcaag 3187981 cattttaaca cccagctcag gaagagtgaa attgaaaacc agcaccaaga tcatactgat 3188041 taacggagca gctgcaagcg gctcacaaag accatgcagg attgattttc ctgtcatctt 3188101 ccagaagctg tcgccactct cttcgttttt cttagaagac tcaccaacag tagcgataat 3188161 gatcgcgagc ggatcaagaa tcgcgttaac cacgatacct gtgaccgcga tcggaatcgc 3188221 aacttcattc gctccgaata agcttcccaa taccgggata cccataaatg cgaatgtcgg 3188281 ctgtgcagag ttcaaagaaa atacagatga gttcgttaaa tcatacttga atataaatct 3188341 gcaaaccaaa agaatgatga tatagaaacc aacaatccca ataattaaag aaatcattaa 3188401 aggtacttgt gataaaaatt cacttctgga agttgtcaaa ataccagcga taaagtgagc 3188461 tggaagtgcg tatttcgtta ctaacgtact tacccctttt gccgacttgg catcataact 3188521 tccaaaatgt cctgcaaacc aacccagcac gataacaaag aagatcggcg ccaggaggat 3188581 taagatatct aagatgctca aaatattctc ctccaaatcc tatgtccgta tactttagct 3188641 ttacaaaaag ctttccctcg gacagaaaaa tttactcgct aattatttcg cgatgacttt 3188701 tttgtattca ggtgtccaca ttgcatcaag taccgcttgt ttcacatctt caggctgacg 3188761 atttgccacg ccgtctttaa ttgctgcttc agcaacggca atcgcaactt ggatagaaac 3188821 ctcttgaagc ttatcaatgc ttggaagcaa tcctgctcca ggtgtttcaa gatcaaccat 3188881 ttcagcaatc gcatcagcag ttgcagcaaa catagcaggt gtaatgatac gcgcttcagc 3188941 tacaattgaa ccaagtccaa gaccagggaa cgcgaatgcg ttgttagatt gtccgatttc 3189001 ataagaaaca ccgttgtatt ctacattgtc aaatgggctt cctgttgcaa taagcacttt 3189061 tccgtcagtc catttgaaca gatcttcagg aacagcttca gcaaggtgag tcgggttaga 3189121 catcggcatg ataaccggac ggtctacgtg agatgccatt tcttttacaa tttcctctgt 3189181 gaatgcacct gaaacccctg aagtaccaat caagattgtt ggtttcgctt gacgaacaac 3189241 ttcatcgaat ggaatttgac ctttttcatc gcgcttccag tctttcactt catccgcatt 3189301 gcgaaggtaa ggtttttgga aatcaaggat gccttcgatg tcttcagtca gcaagcctct 3189361 gtaatcaagt gtgtagaaac gtttgttagc ttcttcttca gataatccgg ctagcaccat 3189421 tgtgtcacgg atttggtcag caataccgat accagcagaa ccagcaccga agataacaac 3189481 acgctgatct ttaatagaag cgccggtttt cttcatagcg gcaagcacac ctgcaagtgt 3189541 aatcgcgcca gtaccttgaa tatcatcatt aaatgtcagg atttcatgat tgtatttttt 3189601 catgatgttg cgtgcatttt tgttgccaag gtcttcccag tgaagaagcg ctttagggaa 3189661 gaatttcaat gcagctttta cataagcgtc aatgaaagct tcgtagcgtt caccttgaac 3189721 acgttcatgc ttgttaccaa tatataaagg atcgtttaga agtttttcgt tgttcgtacc 3189781 gacatcaagc acaaccggga taacacggct agggtcaata ccagctgcag cagtgtagac 3189841 agccaattta ccgattgcaa tattaatacc gcctacaccc cagtcaccga taccgagaat 3189901 gctttcggag tcagtagcaa cgataagatc aatatcgcct gctgtcgcat gaaggttttc 3189961 aaacgctttt tcaataccgt caatgttatc gattgacaag tagattcctt gaggtcttct 3190021 atattcatgg ctgtattcct gaatcgcttc accaactgtt ggcgtgtaca caacaggaag 3190081 catttcgcga agatggtttt tcagcaattt atagaaaaga acttcgttac ggtttgcaag 3190141 atcacttaag taaacatttt gacgaaggcg gtcaggctgc gcttggaatt gctcgtacgc 3190201 gcgttgtgct tgttgatcaa gagaaagtac agttggcggc agaagccctt ctaagccgag 3190261 ttcttgtctt tcttctagtg aaaaagcaac gcctttattt aaagtaggaa tagataaaac 3190321 ttcttttcct ctaagagttg tttctaagtg gccttctttc gtttttttta tgttattcaa 3190381 gcaaatctcc ttctttcttg aaatagttaa ccaagttaag taataaccca tctaaaatat 3190441 gaccgatcat gatctttatg cgactttgtg acaattattc gaacaatgtc tcaaaactat 3190501 ttacattacg taagctattg tatgcctgtc aaaatcaaaa ttcaagagaa gaaaattact 3190561 taatttttta atatacttat ttaaattttt taattgaata ttatcagaat ataaaaaaaa 3190621 caccggtgtt tttagccggt gcattctatc tttataccca tgttttggac tattttttag 3190681 atttacctgg gacttcgtga tgatgtctgc atcttgcttc atatgattca gctgcaccaa 3190741 ccaaaatgac cggatcatcg taagaagcag gtttgccgtc aatgaggcgc tgtgttctgc 3190801 tcgccggtga tccgcaaaca gaacagacgg cttgcagctt tgtcacactt tccgcaatcg 3190861 ccatgatatt cgggacgaca ccgaacggct ctcccctaaa atccatatca aggcctgctg 3190921 ctatcacacg gtagccttta tcggcaagag atgataaaac ctcaacaatt tcctgatcaa 3190981 aaaactgcac ttcatcaacc gcaaccacat ctgtactttc actgatgtga tcccaaatgt 3191041 ccgcagcaga cgaaatggca tagctcgtca tcgatgttcc attatgggag acaacagcag 3191101 cttcgctgta tcggttatca attacaggct taaataccct gacttcctgc ttggcataag 3191161 ttgctctctt cactcttctg atcagctctt cagatttccc cgagaacatg ctgccgcaaa 3191221 tcagctcaag ccacccgctt tgtttcatta tgtacatagg cttcgctccc ctctctctgc 3191281 cagctgtgtt ttagacaata taaaaaacag gcaagactgc tgcttgcctg ttgagaaatc 3191341 tattattact taagaccgta ttttttgtta aagcgatcaa cacgaccatc agcagaagcg 3191401 aatttttgac ggccagtgta gaatgggtgg cattcagagc aaatctcaac gcgtacctct 3191461 tcttttactg agcctgtttc aaattcattt ccgcaagcgc atttaactgt tgcttttttg 3191521 aaattaggat gaattcctgc tttcattgta tccatctcct tccgccctga atcccgtgtg 3191581 gaaacagagt tattatttcg gagcattgtc cgaaacgcat atgagaaaat tatatcagtg 3191641 atttacttct tttgcaaata caatttacct tcttgcagat gatagatttg cctgtttcca 3191701 ttcttgattg agaatatcga aaaattcctg gtttgttttg gtttttttca tttttctcat 3191761 gaacttttct gcgaaatcag gtgaatcaga catcgttttg cggatagacc ataaacgatc 3191821 aagatgctct ttaggcacaa gcagctcttc tttgcgcgtt cctgaacggc ggatatcgat 3191881 ggcagggaag atgcggcgct cggcaagaga gcggtcaaga tggagctcca tgttgcctgt 3191941 tcccttgaat tcttcataaa tgacatcatc catacgtgaa cctgtatcga ccagagccgt 3192001 agcaaggatg gttaagctgc cgccctcttc gatatttctc gcagccccaa agaagcgttt 3192061 cggacggtgg aacgccgctg ggtcaatccc cccggaaagc gttcttccac ttggcggaat 3192121 cactaagttg taggcgcggg caagacgtgt gatgctgtcc atcaggataa tgacgtcttt 3192181 tttgtgttcc acgagacgca tcgcacgttc aagcacaagc tcggccactt tgatatggtt 3192241 ttccggcact tcatcaaacg ttgagctgac gacatcccca gctacagagc gctcgatatc 3192301 ggttacttcc tcaggtcttt cgtcaattaa aagcacgatc agctctgctt caggctggtt 3192361 cgctgtaatg ctgttggcaa tttccttcag caacatcgtt tttccggctt tcggcggcgc 3192421 aacaatcaat ccgcgctgcc caaatccaac cggcgccatc atgtccataa ttcttgtaga 3192481 caagaagttc ggctttgttt caagcaccat ttgacgatcc ggataaagtg gcgtaagagc 3192541 cgggaaatgc acacgctctt ttgcagattc gggatcatcc ccatttactg cttcaacgtg 3192601 caaaagtcca tagtaacgct cattttcttt tggcgggcga accttgccag atactttgtc 3192661 tccgttccgc aaatcgaaac ggcggatttg tgaagctgag atgtaaatgt cttctgagct 3192721 tggagagtag ttgatcggtc tcaggaatcc gaaaccttca gactggatga tctcgagaac 3192781 gccttccata aacagcagat cttcctgttc tgcattcgct ttcagaatgg cgaaaatgag 3192841 ttcttttttt gtcagtttgc tgtaatagga gattttataa tgtcttgcaa gttcataaag 3192901 ctctttcaat ttcatatttt ccaaagagga aatagatacg tctttcataa aaacaccacg 3192961 cttttcatag tcaatatctt actctgaaca tgtcatctgc tgcttttgca caacatccgc 3193021 caaagcacat tcttttttta acataaagga acttctatcg gtaacacttc cacccatgat 3193081 cggcgctttt gttaaaagga ttgtcttaat gagttttgaa ggaagcgagg acaaaaacat 3193141 gagaagatca atacttatat cgtctgtatg cggtagaaat tgaaactttc ctagtgctta 3193201 aaagaaggta ttacgcagta aaattcgcag cactctttat ttttacctta tttcaaaaaa 3193261 ttattcaact gaaataaggt tttgacacgg aattgataga gttgacgctt ttctgcaaaa 3193321 gttaaagcgg gctcacaccc gctttttctg tttgttatgg acggattaca agatttggtt 3193381 tctttttcaa gctgtgtctg ccgtcaacga aacgaacagt gcccgatttt gcacggataa 3193441 ctaagctttc agttgtaccg acagagcctt tgaattgaac tccttttaac agctcgccgt 3193501 cagtaacccc tgtagctgca aaaatcgcgt catcaccctt cacaaggtct tccatgcgaa 3193561 gcactttgct taaatcaagg cccattttgt gacagcgagt gatttcttct tcgctttgcg 3193621 gaagaagttt accaatgatt tctccgccga gtgcttttag cgcaacagcg gaaagcacac 3193681 cctcaggagc gccgcctgat ccgaacagga tatcaacgcc cgtgtggtcg aaagccgtgt 3193741 tgatggcgcc tgcgacatcg ccgtcattga tcaatttgat tctggcgccg gcctcacgaa 3193801 gctcggaaat gatttttgcg tgtctttcac ggtttaaaat tgtggcaacg acgtcctcaa 3193861 cgtccttgtt tttcgctttt gccaccgctt taaggttgtc aatgacaggt gcttcgatgt 3193921 caatgcagcc caccgcttcc ggaccgactg cgattttttg catatacatg tcaggagcat 3193981 tcagaagcgt gccatggtct gcgaccgcga taaccgtcag cgcgttccag ccgccgcttg 3194041 ctaagatgtt tgtgccttca agagggtcaa ctgcgacatc aacgcgaggg ccgtacccgt 3194101 ttccgagttt ttccccgata tacagcattg gcgcttcgtc catttcccct tcaccgatta 3194161 caacggtccc tttcatcggc actgtatcaa aaacgtctct cattgcactt gttgccgctt 3194221 catcagcctc atcttttttt ccccggccca tccatcttgc tgatgccaat gccgcagctt 3194281 ctgtcacacg taccaattcc attgataaac ttctttccat ttcaacacga tctcctctca 3194341 caagaaacca ttatgaattt tgaagctgtt ctatttcttc gtcagtcatt ctttcacgcc 3194401 aaattgtcgc tccaagcccc tcaagcttct tctcaaggct gctgtatcct cggtcaatat 3194461 gctccagtcc cgtaatttcc gtgacgccat cagccatcag tccggctacc accaagcagg 3194521 ctccggcacg cagatcactc gccttcactt ttgcgccttg aagctcgaca ggacctgtga 3194581 tgatggcaga tctgccttct actttcatat tggcacccat tcgtctcagc tcatcaatgt 3194641 gcttgaatct tgccgagtag atggtgtctg tgacgacact cgtccctttc gcccttgtca 3194701 ggagcgccgt catcggctgc tgtaaatcag tcggaaaccc cgggtatacg agggttttga 3194761 cgtcaaccgg ctttaagttc ttctgcccgc cgacaatgag gagctggtcg tcgcttgttt 3194821 cgatatgata gcccatttct ctcagctttg ccgttaacga ctcaagatga gtagggatga 3194881 cgttatcgat aatgacttcc ttgcccattg cagcccctgc aatcataaat gtcccggctt 3194941 caattctgtc cggaatgatc gtatgcttgc agccgtgcag ttccttcacg ccgtcgattc 3195001 gaatcacatt ggtgcccgca cctttgattt tggcgcccat gctggtaagc aatgtcgcga 3195061 cgtcaatgat ctcaggctcc ttggcagcgt tttcgatgat cgttttccct tctgccaaaa 3195121 cagcggcgag cataatgtta atcgttgccc caacgcttac gacatctaaa taaatccgtg 3195181 cgcctctcag cctttcagct cgcaaataaa tggcgccttg ttcattggtt acttcagctc 3195241 cgagtgcttc aaagcctttg atatgctgat caatcggacg gggccctaag tgacagccgc 3195301 caggcaatcc aatgaccgcc tgcttgaagc ggccgagcat cgcccccatt aaataatatg 3195361 acgcgcgaag cttttttact ttcccgttag gaagcggcat gctgatcatc gacgtagggt 3195421 caacaaccat ttccccattc tcaaaatgca cgttgccgcc gatttccttt aacaggtcac 3195481 gcagcgtttc aatatctgaa atctctggaa gcccttcaat tgtcacctcg gaatttgcca 3195541 aaatggttgc aggtattaac gcaacagcgc tgtttttagc gccgctgata tgtactgtac 3195601 cgtttaacga gtcaccgccg gcaatattca acttttccat gatagtctcc ttccataaga 3195661 agatagctgc ggagctaaat aaaatgtcat tttattctgt ctctgcaaat aaagctcatg 3195721 tccaaaatct agccaattcg aagagaaaga atacaacaca ttgtaaaata tcaggaagaa 3195781 aatagcgaag ctttgggggg tacaggtttc aaaagatgca cagagacccg ccggctcgag 3195841 agacatcgtc gtcatccggc aaaagcagta cgcataccct tcattccgat atcagcttct 3195901 gcagcccaat gattccttct ctgtaaagcg gcgtcagcat ctgaagatcc gctgtatcag 3195961 gtcggtgaaa tacaaaggcc gcggcaaaca ggcataaagc tgtttgccgc ccctttcatt 3196021 atttgttcca gtctgccagg aattgttcga ttcctttgtc tgttaacggg tgtttagtga 3196081 gcgcatgaat gactttcagc ggcattgtgc cgatatgagc ccctctaaga gcagcttctg 3196141 tcacgtgctg cggatggcgg attgacgctg caatgatttg cgtgtcaagg ccgtgaatgt 3196201 caaaaatctg tttaacttct gaaatcaggt caagcccgtt gtggccgatg tcatctaaac 3196261 gtcccaggaa tggagataca tatgttgccc ccgctctggc agcaagaagc gcctggttgg 3196321 cattgaagat caatgtaacg tttgttttga tgcctaagtc agtaagtgct cttaccgctt 3196381 ttaaaccgtc agacgtcatt gggattttca ccgtaatgtt cggagcgatc ttcgccagtt 3196441 cttttccttc ctcgatcatt tcctcagctt tcaaagaaat aacctctgcg cttacagacc 3196501 ctttcacgac gtctgtgatc tcgcgaagac ggtcgtggaa tgatacgtta gcttcctttg 3196561 ctactaaact aggattcgtc gttacaccgg cgagaattcc taattcattc gcttctctaa 3196621 tttcatcgat attggctgta tcaacaaaga ataacatttt caaaaagcct ccctgattaa 3196681 gaaattttct gaactgcgaa tatgattgcg ctttctaaag atagacggaa aaccgcctgt 3196741 caagctgtca ggcggctata aaaagttcca attgaattaa gcttggtttg aagaaccaaa 3196801 ttcacgcatt ttaccgataa ctgtttcttt gatcgcttca cgagctggtc caaggtattt 3196861 acgtggatcg tactcgtcag gcttagctgc caatgtttcg cgaacagctt ttgcagaaga 3196921 aatttggttt tcagtattca cgttgatttt agctgtacca agtgaaattg attttttgat 3196981 gtcagcagtc ggaattccag taccgccgtg aagaactagc ggaaggccag ttgattttcc 3197041 gatctcttcc atttctttga agccaaggtt tggctcacct ttgtaagggc cgtgaacaga 3197101 acctaatgca ggtgcaaggc agtcgatgcc agtgcgctca acaagctctt ggcactcttt 3197161 aggatcagcg tagattacgc cttcagcgat aacgtcatct tcttgtccgc ctactgttcc 3197221 aagctcagct tctacagata ctccgtggaa atgagcaagc tcaacaactt tagcagttgt 3197281 tgctacgttt tcttcaaatg gatggtgaga agcgtcgatc attacagatg tgaaacctgc 3197341 atgaatcgct ttcgcacaag attcaaagct tgaaccgtgg tctaagtgaa tcgcaacagg 3197401 aactgtcact ttgtactctt ccataagtgc ttttaccata gcaacgactg ttttgaagcc 3197461 gcccatgtag cgtcccgcac cttcggaaac accaaggatc actggagatt tttcttcttc 3197521 agctgcttgt aaaatcgctt gagtaaactc aaggttgttt aagttaaatt gtcctacagc 3197581 gtaccctttt tctttagctg tattcaacat ttccgtcata gaaactaaag gcatgtcgaa 3197641 tgtcctcctt atgtagcctg attgtcttct agcgaaaaaa gctttccacc ctagcatgac 3197701 ccatatattg ctgtcatatg taaatactca gatcgctttt tctccataac taggatacca 3197761 acttttcgac aaatcggcaa cataatgaca tgattcattt gtttcttctt tttgtcagtt 3197821 agacttcagg ggcagatatt ttttgacggc gtctctgatt tcgtcgatgt caaacggctt 3197881 ggcaaagtgc gtcagagcgc ccaattcctt cgattcctgg atcatgtcga gctctccgta 3197941 tgccgtcatg ataatgaccc ggatgttttc gtcaatgacc ttcatccgtt ttaagatttc 3198001 gattccgtcc atgccgggaa ttttcatgtc caacagcaca aggtcgggcc gttcttttgt 3198061 cacaatgtca agcgcctgca ggccgttcgc agcctgaaac gtctggtagc cttctttatt 3198121 gaacacttca tttagcaaaa tacgaatgcc gtattgatca tcaacgatta aaattttttc 3198181 attcatcatt ttacacccca atattatgat tttcgtcaaa agtaagcagt attgtatgta 3198241 ttctgtttga ttttcctatt tcctttaatt ataatagtct actttacgac attttctgag 3198301 cattttctct tttgttgtat actgatattg tacgttataa aggaggattc acttatgttg 3198361 aaaatattca cgacgcagtt aacaggtatt ttttcccgca ttcaggataa ggaatctgac 3198421 gcgattgaag atggggcgcg gctgcttgct caagcggtga tcagcgggca ttccatttat 3198481 ttatacggag cgaatgagct tcagggcgtc ttttatgagg ccaccgaaag caaagaaccc 3198541 ttcccatctg tcaaagcctt tccagaaaac gctgaggaag tgacagaaag cgacagggtg 3198601 ctgatgtttt gctcagggac gggcacagcc gaagaacagg agctcgcaaa agagctttat 3198661 gaaaaaggtg cgggagtcgt atgcgtatcg cccgcagcca aagacagtgc gggaatagaa 3198721 cagtattgtg atgtgcatat tgattctaaa ttaaaaatgc cgcttgttcc cgatgaagac 3198781 ggcacccgtt acgggtttcc ctctttaatg acagcactgt atgtctatca cgctttatcg 3198841 tttacactaa aagaaattct gcaagagtat gcataatatc ttattgtaca tgctggaact 3198901 tgccggaaac aaataaaaaa gacttgcccg cttttgacaa acggcaagtc ttttttatta 3198961 cttctgattt gcagcttcga cagacgctcc gataaagcct ttgaatagag gctgaggtct 3199021 tgtcggtctt gacttgaact ctgggtggaa ctgagaagcc acgaaccaag ggtggtcttt 3199081 cagctcgatg atttcaacaa ggcgtccatc agggcttgtg cctgagaata cgaagccttg 3199141 ctcttccatt tgctgtctga attcattgtt aaactcatag cggtggcggt ggcgctcgta 3199201 caccacttca tcctgataca cttcaaaggc tttcgtgcct tcttcaagct tacaagggta 3199261 aaggccgaga cgaagcgttc ccccaagatc ctcaacatcc ttttgttcag gaagaagatc 3199321 aatgatcggg tattgagttg acggatcaat ttccgctgag tgagcgcctt ttaagcccaa 3199381 tacgtttcgt gcgtattcaa tagacgccac ctgcatgccc aagcaaatgc ccaagaacgg 3199441 aatgttgttt tcgcgcgcgt attttgtcgc gacgattttc ccttcaacac cgcggtctcc 3199501 gaatccgccc ggcacaatga tgccgtctgt tccgcttgtg agttctgcga tattgttttc 3199561 tgtcacttct tccgcgttga tccacttcac ttttacatct gtgtcaaacg catagcccgc 3199621 atggcggaga gactcgacaa cagaaatgta tgcgtcagga agctcaacgt atttgccgac 3199681 aaggccgatt gtaatcgttt gagacaggtt gctgactttg ttaacaagct ctttccactc 3199741 ggacatttcc gcttctttgc atgccaattt catgtgctcg caaacaagct tatcaagccc 3199801 ttgtttttga agctccagcg gaatggagta aaggttgtcc gcatcttcac attcaataac 3199861 cgcttttgta tcgatgtcgc agaaaagcgc gattttatct ttcatatctt gagaaatcgg 3199921 catttctgta cgaacgacga tgatgtttgg ctgaatgccc aagctgcgca attcttttac 3199981 gctgtgctgt gtcggttttg tttttaattc gccagcagct ttaatgtaag gcacgagcgt 3200041 acagtggatg tacattacgt tttcacggcc gatgtcgctc ttcatttggc ggatcgcttc 3200101 aaggaatggc agtgattcga tgtctccgac agtaccgccg atttctgtaa tgacaacatc 3200161 tgcgtttgtc tctttccctg cgcggtaaac acggtctttc aattcgtttg tgatgtgcgg 3200221 aatgacctgt acggttcctc caaggtaatc tccgcggcgt tcttttttaa gaactgttga 3200281 atagatttta cctgttgtca cgttgctgaa tttattcagg ttaatgtcga taaaacgctc 3200341 atagtgacca aggtccaagt ctgtttcagc gccgtcatcc gttacgaata cttcaccgtg 3200401 ctggtacggg ctcattgttc ccgggtcaac gttgatgtat ggatcgaatt tttgaatcgt 3200461 cacgttcagt ccgcggtttt tcagcaaacg ccctaatgaa gctgctacaa taccctttcc 3200521 aagtgaggat acaactcccc cggttacaaa aatatatttc gtcatttcgt ttgctcctct 3200581 cttcgctctt agctacattt ttaaaatgta ctattttata aaaaatcatt tagcctttta 3200641 aatgatttat aagaaaaatg aggggtgaaa ataagaaagc tccctttcaa tttcttgaaa 3200701 gggagcataa cgtactatgt tctctcttcg tttttgaaga gcccaaaata catactacat 3200761 agttcgacta tgaaagtcaa gatcgttttg aagatgaaat ctgatactat ttaatttcct 3200821 cttcttcatc atcatagtct tcatcatctt catcaataat atcttcttcg atctcaagat 3200881 catcgtcgtc ttcatcaaga tcttcttcgt caaaatcgtc ggcttcaaga tcgagttctt 3200941 cctcaacttc atccaaatca aggtcgtctt cgtcgatctc ttcaaactcg tcaagatcaa 3201001 gatcttcttc gactgctttc ttcgcttttt tctttttcgc cttgactgtc ggctgagttt 3201061 cttcatcaag ctgatcataa ggataccagc tgcgaagccc ccacgtctgg tcagaaagcg 3201121 ccaggaagcg gccgtcaatg tttaaatctg tataaaattg agcaatgcgg tctccaagct 3201181 cttctttttt cacgccgagc aaagatgcga tttcatttaa aagctcctga aaaggaactg 3201241 gttttttatg ttcttcaaat aattcgtgag cgatttcaac taaagccatt tcctttagct 3201301 cttcctgtga atattgtttg atacccaagg tcggacactc cctttctatt acttatatgt 3201361 atctgtttta tcaataatga aagcgatttt gtatcgttct tatacaaacc atacctctca 3201421 ttataaacaa aataaaacag aatatgctac ccttaacagc gttaatttaa ataattttac 3201481 aagagtgatc cgactgagag atgttttccg ttaatccgcg agcattctgg agatgaccag 3201541 tctttgaatt tcttgagtgc cttcatagat ttgcgtgatt tttgcatcac gcatatagcg 3201601 ttctaccgga taatcttttg tatagccgta gccgccgaaa atctgcacgg cttcggtcgt 3201661 taccttcatc gccgtatccc cagccatcag tttggacatg gcggaagctt ttccatatgg 3201721 aaggcccgat gattctaacc atgcagcctg ataggtcagt agccttgaag cttctatcat 3201781 tgtcgccata tccgcgagtt taaaagcgat gccctgctgc tcggcgatcg attttccgaa 3201841 ttgctttcgc tcttttgcat attgaagcgc cgcatcaagc gctccttggg cgatgcctac 3201901 agcttgtgca gctatgccgt ttctgcctcc gtcaagcgtc ttcatcgcga ttttgaagcc 3201961 ttctccttct tctccgagac gctttgatgc gggcactaca caatcttcga acatgatttc 3202021 cgttgtcggt gaagaacgga tgcccagctt cttttctttc ttgcctgtaa aaaatccttc 3202081 aaaatccttt tctactataa aagcggtaac gccttttttc tttttctcgg gatcggtgac 3202141 ggcaaaaaca atgtaaatat cagcaacgcc gccgtttgtg ataaacactt tggaaccatt 3202201 taacacatag tcatcgccga ttcgttcagc agttgttttc atgctgccgg cgtcagagcc 3202261 agaccctgct tcggtcaaag cgaatgcgcc gattttctct ccgagagcca gctgtgttaa 3202321 gtactctgtc ttctgttcct ctgtcccaaa ggcaaacagc ggccagctgc aaagagagat 3202381 atgggcggaa agcgtcacac cggtggaggc gcacactttt gacagctctt ccaccgcgat 3202441 gacgtaggct aaatagtcac ttccaattcc gccgtaatct tcaggccatg gaattcccgt 3202501 caggcccaga tttgccattt cccgaaacag ctcgcgatcg aagcgttctt gttcgtcccg 3202561 ttcagccgct gtcggggcca cctcatgctt cgcaaaatcg cgcaccaatt ttcgtatcat 3202621 ctcatgttct tctgataatg aaaaattcat tgcttctccc ccattttcag atcagcgcct 3202681 aaaacggatt gagccagaag ctcgacgacg tcgtacgttt tgacttggtc ttcggcttcc 3202741 ttcgcctttg tgccgtcccc aagcatcgtg agacaatacg gacagccaga actgatcacc 3202801 gatgggttga ctgcgagcgc ttgctctgtc ctggcgacgt taatcctgtt gcctgtttct 3202861 tcctccatcc acattaatcc cccgccggct ccgcagcaca tgccggtttc ccggcttctc 3202921 tccatttcaa caagctgcac gcccggaatg gctttcaaaa tctctctcgg cggatcatag 3202981 acttcattgt accggcccaa atagcacgaa tcatggaagg taatcgtctc atgaagcggg 3203041 tgctgcggtc ttaattttcc gtttttcaca agctcggcca gcacttctgt atgatgataa 3203101 acctcgcctt caaatccgaa atccggatat tcgtttttaa ataaattgta tgcatgggga 3203161 tcgatcgtaa cgattttttt gacatcattt ttttcaaatt cagaaatatt cttctcagcc 3203221 agctcttgga acaaaaattc atttccgagg cggcgcggcg tgtctcctga atttttttct 3203281 ttattgccga gaatcgcgaa ggacacgccc gcgtgattga gcagcttggc aaaggaaatt 3203341 gcgattttct ggcttctgtt gtcgtaagac cccatggagc ctacccagaa aaggtactca 3203401 aattcttttc cttctttttt catttctttt acagtcggaa tctcagcatc cggcgcctcg 3203461 tcacgccaat tttcacgttc cttgcggttg agtccccacg gattcccttg ccgctcaata 3203521 cttgtcattg cgcgctgggc gtcactgtcc atttttcctt ctgtcagtac gaggtagcgg 3203581 cggaggtcga tgattttatc cacgtgctca ttcatgaccg ggcattgatc ctcacagttc 3203641 cggcaagtgg tgcatgccca aatttcttcc tctgtgatga cgtcgccgat caagcttgga 3203701 ttgtaatcaa gcgccgctgc ggcttcctgc gatccgctgc ccgctgacgc cgcagccagc 3203761 tgattgcctc tcgtatgccg aaacgctgct gcgggcaccc atggggagcg cgaggtgacg 3203821 gcagcgcctt tttccgtgag atggtctctg agacgcaaaa tcaagtccat cggagaaagc 3203881 atttttccgg tgcctgttgc aggacacata ttggtacagc ggccgcactc gacacacgcg 3203941 tatagatcaa gcagctgaga ctgtctgaaa tcctcaattt ttcccgctcc gtagctttct 3204001 ttcgtttcgt cggtaaaatc aattttttca agttttccgg cagattccat tcgattgaaa 3204061 aagacgtttg ccgggccggc gattaaatgg gcatgctttg actgaggcac gtacactaaa 3204121 aagctaagca agaataggag atggatccac catgcgatat agaaaatcac cgccgcgcct 3204181 gttttcccga caccgctaag cataaacgca atacctgagg caattggctc gctccaagaa 3204241 agcccatgct catgccaaat cagattcatc ccgttcccaa gcagaacggt cagcattaat 3204301 cctccgataa aaatgagaac gagtccggct ttgaaaccgc gtttcagcct cacgagcttt 3204361 tcgatataac gtctgtagaa tgcccaccca acagcaatta aaatgagaaa cgtaacaatt 3204421 tcctgaaaaa aggtgaaggc gggatagacc gggccaagcg acagattccg gccgggagcc 3204481 agtcctttga tgataaagtc aattgctccg aactgaacca atataaatcc gtagaaaaac 3204541 atgacgtgaa tgattccgct tttcttgtcc ttgagcagtt ttttctgtcc gaatacattc 3204601 acccatatgg cgtgaagccg ttccttgaac cgttgatcaa attgttcttt ctggccgagc 3204661 ttgatgtagg ccagtctcgt tttgaccaag taaacaaaca aatagacagc gtaagcggtt 3204721 acaatcagaa ataataatgc atttgcgatg agaaagccgc tcattccaat tccccctttt 3204781 tactgataaa gaccgcgatc ccctaccccc gaatctgtat aagattatct ttatgataaa 3204841 taatgaatga gtgttcagtc aataattaaa ttcctgctgt tcgggcacac tacctttact 3204901 acggaaagga gtgccggtat gaaggtattt atcgtgatta tgatcattgt cgttattttc 3204961 tttgccttga ttctgcttga tatcttcatg ggccgtgccg gatacagaaa aaaggcgtac 3205021 gagcctgttt tttcaaaaaa gaagagtgac atcgaattga tccactgcgg cgctgatctc 3205081 gttgagcgga tgatgaatga tattcgccag gccgcctctt ctgttcacat gatgtttttt 3205141 attatgaaaa atgatgaggt cagccacaat atgtatacct tgctgaaaac aaaagcccaa 3205201 gctggcgtat ccgtttattt gcttctggat tgggcgggct gccgggcaat taaaaaaacg 3205261 gcgcttcaga cgatgaaaaa tgccggcgtc catgtccatg tgatgaatcg tccccgtttt 3205321 ccttttttct tttttcacat gcaaaaacgg aatcaccgga agattacggt gatagacgga 3205381 aaaatcggtt atatcggcgg gtttaatatc gccgaagaat atcttggaaa gaaggcgaag 3205441 ttcggcaatt gggaggatta tcatctgcgc atgatcggag aaggcgtaca tgatcttcaa 3205501 acgctttttg cttctgatct aaaacgaaat accggaatcg aactgggttc ggatgtttgg 3205561 ccaaagcttc agcaagggac tatttctcac aagatctatg cgaccgacgg ttattccctt 3205621 gaaaacatat acttggccaa cattgcccaa gcgaagaatc gccttacggt ttgcacgcct 3205681 tattacattc catcaaaacc gcttcaagag gcccttatta acgcaagaaa aaacggcgta 3205741 tccgtgagaa tcattgtacc gatgaaatca gaccatccgc tggtacgaga agcggctttt 3205801 acgtattatt cggagctctt ggatgccggc tgtcttattt atcgttatta tcaagggttt 3205861 tatcatgtaa aagccctcat catagacgac catctcagca ttatcggaac agccaacttc 3205921 gataaacgga gcctgttctt aaatgaagag gtgaatgttg aaattgatga cgaagcgttt 3205981 acaagtgaag tctatgccac aattgaggag gatatgaaaa agtcggagct gctgacgatg 3206041 gaggatttca gcaagcgcac attcaggcag cgcccggcgg aatggctcgg cagggcatta 3206101 tcttatttct tataaaggag agttcctatg attttcagat tcgggttcgt ttcaaatgcg 3206161 atgagccttt gggatgcgtc tcccgctaaa acattgacat tcgcgcgtta ttcaaagctt 3206221 tcaaagactg aaagaaaaga agcgcttctg actgtgacaa aagccaattt gcgcaatacg 3206281 atgagaaccc ttcactatat catcggccac ggcattcctt tgtaccgttt ttccagttcg 3206341 attgtgccgc tggctacgca tcccgacgtg atgtgggatt ttgtaacacc gtttcaaaaa 3206401 gagtttcggg agattggaga gcttgttaaa acccatcaac tgcgaacaag ctttcatcca 3206461 aatcaattca ctctgtttac gagcccgaag gaatccgtca caaaaaatgc ggtaacagat 3206521 atggcgtatc actaccgcat gcttgaggcc atgggcattg ctgatcgctc cgttatcaac 3206581 attcatattg gcggcgctta cggaaataaa gacaccgcca ctgcacaatt tcatcaaaat 3206641 ataaaacagc tgccgcagga gatcaaagag cggatgacac ttgaaaatga tgataaaaca 3206701 tatacaacgg aagaaacgct tcaggtctgt gagcaggagg atgttccgtt tgtctttgac 3206761 tttcatcatt tttacgccaa tccagacgat cacgccgacc tgaatgtagc actgccccgc 3206821 atgatcaaaa cgtgggagcg gatcggcctt cagccaaagg ttcacttgtc ttccccaaaa 3206881 tcggagcaag cgatacgcag ccacgccgat tatgttgacg ccaacttttt gctgccactg 3206941 ttggaacgct ttaggcaatg gggaactaat attgatttca tgattgaagc aaagcagaaa 3207001 gacaaggcgc ttctccgctt gatggatgaa ttaagctcca tccgcggtgt caaacgcatc 3207061 gggggcggtg cgctgcaatg gaagtcataa atgtgcaaaa ataggtttac gacttgtcag 3207121 ctttgggaac ttaggctata taagacaaca atcgatggag gagaaagatc atgaaaaata 3207181 tcaagtctct gaaagtagcc gcacaggcct ttactttaag aaatttgatt catctttata 3207241 aaatgtgcca ttccggaagc cacgaggttt atatttattc aaagaaaacg atgtgcaaaa 3207301 tcaaaagctt aattgagctt gaaacgttcc gcatggctca taatgaaaag gaatatctga 3207361 tcgtagttga aggaacaaaa gcatcacagc tcattgaaaa attccaaaat ctcatcgagc 3207421 ctgctgagag agaagcgctc taacttacat acaaaaaagg atagacatct gtctatcctt 3207481 tttcttatgc tcttacataa tggagctgaa ccgcttgtcc aaattgtttt gtccctttta 3207541 accgcagttt tgtttcattt gttagttcgt gaaacagcgg gatgccgctt cctaaaacga 3207601 cgggaataac agtgatgatg aattcgtcga tggcatcttc tttcataaag tcattcacaa 3207661 gctctgcccc gccagctatc cagatgtttg agcctttttc ctgtttcaaa cgggcagtga 3207721 aggctctggc tccctcattg ataaacgtca catgttcatc ttgataactg tcgggcgatc 3207781 ctgtaaaaac atagcaggtt ttatcctgat acgggaaaac cggtgttagc actttaacgt 3207841 gctcatatgt gctccgccct aaaatgactg tatcaacagt ctgataaaaa tcactgtagc 3207901 cgttgtcacc ttcaccttca aattcatcca gccaatcgat gcttccatct tcttttgcga 3207961 tcatcccgtc caatgaaaca gcaatgtaca gcacagtttt tctttccatg ttctcctcct 3208021 atcgatgcac catttgcccg aattgcgctt gatgcagcct gctgtatagg cctccggctt 3208081 cgatcaggtc ttgatgacgg ccttgttctt caataccgtt gtttgtgacg actacaattc 3208141 tgtccgcgtc tttgattgtt gccagcctgt gggcgatgac aagcgtcgtg cgcccctcag 3208201 acaactcttg aagcgccttt tggatcgccg cttccgtctc tgtatcaagg gctgaggtgg 3208261 cttcgtcgag aatcaagatc gacggatttt tcaagaacat ccttgcaatt gacagacgct 3208321 gtttttgccc gccggaaagc ttcacgccgc gttcgccaat catagtatcc aacccatcgg 3208381 gcatgttatg gacgagctct tccagatgcg cctgcttcac agcttgccaa atgtcttctt 3208441 ctgatgcgcc tagtcggccg taggcgatat tttctctaag cgtgcccgag aataagaaaa 3208501 cgtcctgctg cacgacgcca atctgcccgc gcaacgaaga aagcgtcatg tcttttatac 3208561 tgatgccgtc aatcgtaatg tcgccctccg atgcttcata aaaacgcgga agcagactgc 3208621 aaagcgttga tttcccagca cctgacggac cgacgaacgc caccgtttcc cccgcttgaa 3208681 tggataggtt gatgtcattg aggacattgt gatggtcatc atagccaaac gaaacatgtt 3208741 tatagcggat attgcccttc aggccggaaa catctttcga atcaggtgag tcctgaatat 3208801 ccggctctgt ctccatgagc tccatatagc ttttgaaacc cgcgatcccc ctcggataca 3208861 tttcgataat ggcattaatt ttgtcaatag gcctgaacag cacattcgtc aagagtacaa 3208921 acgccacaaa ttccccgtac gataaggagc cgcgaatgac aaaccacgtc ccgcacaaaa 3208981 ggacaaacag cgtgacaaac cgggtcagca tatagctgat tgaaccgttt ttcgccatga 3209041 ttttgtagga agaaagcttt gtgacacgaa aacgctggtt gttgacggcg aagcgttctt 3209101 tttcaaatgc ttcatttccg aacgcctgca caagccggat gccgccgatg ttattttcta 3209161 cacgcgcgct gaagtctccg atatccttgt tcagcgtggt aaatgctttg gtcatttttt 3209221 tgttgaaata aagcgctagc caaatgacga tcggcataat gataaacgtt aataaagcaa 3209281 gctgccagtt aataaacagc atcactccga acgccccgag aatggtcatg accgcaatga 3209341 ataagtcttc cggtccgtga tgggcgactt caccgatata cattaaatcg ttcgtgagct 3209401 tcgacatcag cgttcccgtc ttgttgttgt cgtaaaattt gaacgagagc ttttgcaaat 3209461 ggtcaaaaag cgactttctc atatcagtct caatattgat accaagcatg tgtccccagt 3209521 aggtcacgat atactgaaga gccgagctga gcgcgtacac cgcaaataac ccgattgagg 3209581 tcgcgatgat cagtccccag tccctgcccg gcagcaaggt atcaataaaa taattgacga 3209641 tcaaaggaaa actcagctcc attaaacctc ccgcgatcgc tgagaaaaag tcgagaaaga 3209701 acaacgtttt atatggttta taatatgaaa aaaattgccg cagcacccta tcttccccca 3209761 atgtataaat aactgataat atttctcaat tatactatac acgggctgtt ttgtaagatc 3209821 agatttcttt tttcttacag aacacctgaa aacaggcggg caaacgactc ttttgtccgg 3209881 tcagccacac ctcttttata aaagccgaca gggctgagct tttcactttc ctgcatatcc 3209941 tcttcaaaat gggcctcaag ggttcggatc gcttcggcat ccgtgaagaa cacattcact 3210001 tcaaagttga gctgaaagct gcgcatgtcc atattcgcgg taccgacgga ggcgagatcg 3210061 ccatcaatga tcatgacttt ttgatgcatg aagccttttt ggtaggagta cacttcaatg 3210121 ccctcaagga gcagctccgg gaaataggac ctcgacgcgt attgggtcaa aaagctgtcg 3210181 ttcttctccg gcaccataac ccttacctct accccctttg tcgccgctgc ttttagcgcc 3210241 gtgcgaatgg attcattggg gacaaaatag ggcgtggcga tccatattga tttctgcgct 3210301 gaagaaatca tttcataata aaggtcgctc atgctttcct tcatgtcagg gcctgtcgcg 3210361 acaatttgat aaatgcctcc tccttccacg ggaaccgggg tattgtactc ctcttgatca 3210421 attagcactt cattggagac atattcccaa tccagcataa agatagcgtg gagcgtttgc 3210481 acaatttccc cctcaagccg caggtgtgta tctctccaaa atccgatgta cggatctctg 3210541 ctgatatatt ccttcccgac atttaatcca cccacaaaac cggttttccc atcgatgatc 3210601 acgattttcc ggtgatttct gaaattcagc ttctggttga aaaacccgta tttcagcgga 3210661 gaaaacggga cgatgtccac ccccgcttgt ttcattctca taatatctct tcttgccagc 3210721 ttcatgcttc ctgccgcatc gtataaaaac ctcacctcga caccctggcg cgctttctcc 3210781 atcataatat ccatcatgcc gcgtccgagc atgtctgatt taaacatgta gtattcaata 3210841 tgtatgtaag attccgcttt tctcattgct ttgaaaatgt ccgggaaggt ttcttcgccg 3210901 tttttcagca ctttgatgtt gcttttcgta ttgatattca tatgggcagc cctgatggaa 3210961 tatgtaaaga acctctcttg attgtccttc agccctgtca cttcgggcgt ttcctccttg 3211021 tcaaacagct tcctgagctt ttccctgttg tacattcgtt ttgtcttaaa cagctttccc 3211081 tttacataaa gctgtcccga aaacagataa aacacgtagc cgacgattgg aaaaaagaca 3211141 agaatatgga tccatagcag cgtgtgctgc gaggtgcggt tttcaagaat taatgaatag 3211201 atgctgaaca aaataatgct tatatagcaa agcaatcctc cgtaaaactc aagtctggaa 3211261 accggaaaaa accaaatgac atatgccccg atgagcatca tatataaaaa gaaaaattcc 3211321 agtctccttt tcagcatcct gattctctcc aatctgattc aattacctct gtattacctc 3211381 ttttttctaa tcgataaacc ttgtaagtaa aaaacctctc cgccaaagga ggagaggttt 3211441 agagaaaact aactgtcacg gaattcatcc gcatcgtttc tgcagaaata aagcaagact 3211501 attggcaacg ccgagtgaca acatgagcgg caagctgaac ccgctcagca ctccggcaag 3211561 cgccgaaaag aaggcggcgc tgtgactgca aatacggtgg atagagtaaa tttgataccc 3211621 attctgatga gagaaaatat ataaaacggg aaattgatca gaaagatata aggagttagt 3211681 caggctgaat cataatctgg ctgttccgcc ggtttaaaat gagtaaaatc cttgatgtta 3211741 tttccatata caaacataac aggattcccg gcagcccagc cattaccttg gcagaaaaaa 3211801 ccccctcttg caagggggat tttcacgagc gtttccgata tacaacgtag ctgcgggtca 3211861 gatacttgag cggcagactg aacacatgaa ccaatctcgt aaacggccac aggataaaaa 3211921 cgacgtatcc tatcacaata tgaaacttaa accatagcgg gacactctcc atcaaagagg 3211981 cgtcaggcct gaacaaaacg atttccctga accagggccc gactgtggtc cggtaatcaa 3212041 atcctttcga atcaatgttg agaaacgtgg ccgcaacgcc tgacagcatc atgaacagca 3212101 gcaggaggag cgtaaggata tcggatggcg agctcgtttt gcggattctt ttgtcaaaca 3212161 gccttctgta cgtcaggatg acaagtccgg tacatgccgc aatgcccgcc ggcaagccag 3212221 cgccaatcgc cattttgtga tacatatgct ctgaaatgcc aagggaagca tacacgcctt 3212281 ctgggatcag aatccccatg acatgcccgc cgacaacgca cagcagtccc cagtgaaaaa 3212341 gtgtgctgcc agccgcaagt tttttctttt ctaacagctc gcttgatttc gccgtccagc 3212401 caaattggtc atgctgatag cggtaaatat ggccgccgat aaagattgtc aatacaatgt 3212461 atggcataat accccagagg atctgcccgc tcatgcctga acagcccctt caacgctttc 3212521 acgtacgcca atgttttcaa gcgcggccag cagcacgtgc agcagttcag cgtatatact 3212581 gtcatttttt tcgagacggg atgccagctc cctcacattg gacagatatt tctcaaacac 3212641 gcttctcgct gcttcaattt ctgcagccgc agcaaattcc agcatcagcg gcagataatc 3212701 aggcagctct ttctctgtcg gcaggaaacc ggattgctcg tatgtgtttt ttaaatgcag 3212761 caattcaatg ccgcgttccc tttgctcgcc tgagttaaag taggtgacat acatatttgt 3212821 ttttttcccg aagtcgaatg tatagacata gtgttcaatc agcgcttccg gagaatagct 3212881 ggctgacgtc tcgaaaaagt gcagcagctt ctcccggatt tgccggttgc cgatttcttg 3212941 gataagagcc ttccaatcgg gaagctcggc tctccactct tcatccggat aagagagaag 3213001 acaggaaaga gcagagaacg tgatttgccg gtctgtggtg ttcatcttgt tacacctcat 3213061 ttatcaaaag ttagaaacag gagccggggc cgcctgaaaa tgataagccg cagcttcctt 3213121 gttcagcgta taaatctgat acttcttctc gatggctgct cggaatcaca aagcggtcat 3213181 catatttggc aatcgcaagc agccgataca tatcttcaat ttgctgttct gttaagccga 3213241 cactggagat cagttccgga tcgattgatt tattcgtctg gaccgctctc atatactggc 3213301 gcatgacaga cattttcttt aatgttgacc gaatatgatc cgtatcaccg gctgttaaca 3213361 gctgcgccaa ataatctatc gggattctca tttggtcgat agccggaaaa atatcttccg 3213421 ccgtttgccg gctgcctttt ccttcaaaga gattcataat cgggctgagc ggcggaatgt 3213481 accacaccat tggcagcgtg cggtactcag gatgaagcgg cagcgcgatc ttccagtcaa 3213541 tgatcatttt atagatcggt gattgctgcg cggcctctat ccattcagcc ggaatgcctt 3213601 gttcttttgc cagtttggca acctcaggat cattcggatc aagaaaaacg tccaattggg 3213661 aatggtagag atccttttca ttttcaacag atgccgcttc ctccactttg tccgcgtcat 3213721 atagcatgac gccgaggtag cggattctgc caacacacgt ctcagagcag atggttggca 3213781 gtcccgcctc caaacgcgga aagcagagtg tgcatttttc cgctttgttc gtttgccagt 3213841 taaaatagac ttttttataa ggacaggatg agacgcaata tctccatgaa cggcatgcgt 3213901 tttgatccac aagcacaatg ccgtcctcct cgcgtttgta catggcgccg gatggacagg 3213961 atgagacgca tgccgggttg atgcagtgct cgcaaatacg gggcaaatac atcataaaga 3214021 cgtcatcgaa ttctgttttg atcgattcct ccatcttttg tacgttggga tcttcaagtc 3214081 ccgtaatgtg gccgcctgcg agatcgtcct cccagttcgg tccccattcg atattcatga 3214141 aatcccccgt caaggacgat ttcgggcgtg ctaccggctg gtgttttttc tgcgggctgt 3214201 tcgttaatgt ttcataatca tagttccaag gttcatagta atcatcaatt gacggctgat 3214261 tcggattata gaaaaggcct gcaagccgat tggttttcga gcccgatttc agctcgagct 3214321 ttcctttttt caatgtccag ccgcctttat atttgtcctg gtcctcccat tgcttcgggt 3214381 agccgatgcc cggctttgtt tctacattat tgaagtacat atattccgca ccggaacggt 3214441 ttgtccacgt gtttttgcag gtgacgctgc acgtgtggca gccgatgcat ttatccaagt 3214501 tcatgaccat accgatttgc gctttaatct tcaagccaat cgacctcctt cagcttgcgg 3214561 atgacgacgt tcaggtcgcg ctgattcccc gttggaccgt aataattaaa gccgtagctg 3214621 agctgggcgt agccaccgat catctgtgtc ggcttgacgt gaatccttgt cgggctgtta 3214681 tgggtgcctc cgcggttatt cgtcagcttt gtgccgggca cgttgatgtg gcggtcctgg 3214741 gcatggtgca taaacgccat tcctttagga atccgatgag acaaaacggc tctcgcgacg 3214801 acaacgccgt ttcggttgaa gcattcaatc caatcgttgt ctttgatatc cgtgtcctct 3214861 gcatcatctt tattcatcca cacggtcggc ccgccgcgga acagcgtcag catcggcaga 3214921 gaatcaaaat acatgctgtg gacagaccat ttattatgcg gcgtcaaata attgaggacg 3214981 atttcttttc cctcttgatc aggccgtttg ctcagaaacg ggcgatgctg gaggatcggt 3215041 ttgaatgtcg ccatcgtttc accgaattcc atcatcagtt catgatcgac ataataggat 3215101 tgtctgcctg tcagcgtccg ccacggaatt aatttttcaa cattcgttgt aaacggcgaa 3215161 tacctgcgcc ctcctttttc agagccggta aacgctggag acgtgatcac cgttttcggc 3215221 tgggctgtaa tttgttcgaa cgtaaagcat tcttcctcgc gttcttccgc caggtctttc 3215281 agcttcaggt tcgtgatgtt ttcaagtgat tcccatgctt ttactgcgac ctttccattc 3215341 gaagtggatg atagggttaa aatcgcttct gcagcctgct ttgcttcact tatatttgga 3215401 catccctttg ccacgctgtc cgaggtgatt tctcccagtc tctgtttgag tgattcatat 3215461 tcatcggcta ttgaccagct catccctttt gttccgctcg gctttaaagc aacgttcgga 3215521 ccaagtgcag tcattttatg aaaaatgtgt ttgtaatccc gttcaacgac ttggatgttc 3215581 ggcatcgttt ttcccggaat ggcttcacat tcgcctttgc tccagtcatt gattttgccg 3215641 aatggctggg ccaattcctg catggtgtcg tggagcagcg gtgtcgcaac cacttctttc 3215701 accggctcca tatcgacttc ttctgccaga tcggaaacgg cttttgacag cgccttgaaa 3215761 atatcccagt ctgacttcga ttcccacgga gccgagatcg caggagcaaa tggatgaatg 3215821 aacggatgca tatctgtgct gctgagatcg tgtttttcat accatgtcgc cgccggcagc 3215881 acgatatcgg aatacagcgc cgtacccgcc attcgaaaat caagattgat taataagtcg 3215941 agctttcctt ccggcgcctg ctcccgccat ttgatttctt ctgggcggat gctgtcgctg 3216001 tcgtcattca ttaaaccgtt cgttgtcccc agcaaatgct tgagaaaata ttcatgccct 3216061 tttcctgagc ttgagatcag atttgcccgc catacaaaga gattccttgg gaaattcact 3216121 tcattgtcag gatcttcaat cgcgaatttc agttttttct cttggagctg tgaggccacg 3216181 tacgcaccta cgtcttcagg tgttgctgcc cctgcttttt cagcttcttt atacagatcg 3216241 atgccatttt gattgaaagt cgggtaagac ggaagccacc ctagccgcgc cgccagcaca 3216301 ttgtaatcag cgtggtgctt gtagcgggat gaagcagcaa tcggtgatgc caaatcactg 3216361 atcggctggt cctcataacg ccactgatct gtcgcaaagt agaaaaatga ggtgccattt 3216421 tgcagcttgg gcacgccttc ccagtccttt gcagttgcaa tcgtctgcca cccttcagca 3216481 ggtcggagct tttcctgccc cacgtaatgg gcccagcctc cgccgtttac gccttgggcg 3216541 cctacaagta aaacaagatt taacactgct cggtagatcg tgtcggagtt gaaccagtgg 3216601 ttaatgccgg cccctacgat aatcatggac cggccgtctg tatcgatcgc attttgggca 3216661 aactctctgg caatcttaac gacagcttct tttttgattc ctgtcatttg ttcctgccag 3216721 gcaggcgtaa acggctcagg gtcatcatag gagacagccg atcgttcgcc gatgccccgg 3216781 ttcacgccgt agttagccag tatcaagtca aacacggtcg tgatgtacgt ttcttcaccg 3216841 ttcaggttca tttttttaat aggaagatcc cgctcgagca ctttgtttcc gtcatttgaa 3216901 aaatacggga tgcgcaccgt gccgatttcg tcctctattc ccagcacaga gagacggggt 3216961 tcaatcggtt ccccggtttc ttcatcaatc atgtgcaggt tccatttctg ctgcccgtcc 3217021 cagcgcgagc ccattgtccc ttggggtatg gcaaatgaac ttgtctgttc atcccaaacc 3217081 gcaggcttcc actgatcatg ctttgtcttc cgcccgatgt ccttcgcatg cagaaaccgt 3217141 cccgctgtgt atacgccatt ttcttttgac agagtgacga gaaatggaaa atcagtgtat 3217201 tgcttcgcgt actcaataaa acgttcagtt tcttggttca cgtaaaattc ctgcagaata 3217261 acgtgaccca tcgccatcgc aagcgccccg tcagtccctt ggcgaatact cagccagtca 3217321 tccgcgaact ttgaggattc cgcaaaatct ggactgatcg aaatgacctt agcgccttta 3217381 tagcgggcct ccgccaaaaa atgcgcgtca ggcgttctcg ttaacggaac gttggagccc 3217441 catgtgataa tatagccgga attgtaccaa tcactgcttt ccggaacgtc cgtctggtca 3217501 ccccaaattt gcggggatgc tggaggaaga tccgcatacc agtcataaaa actgagcata 3217561 gggcctccga ttaacgacat aaaccgggag cctgatgcgt ggctgatcat ggacatggcc 3217621 ggaatcggag aaaaaccgac gtttcggtca ggcccgtatt tcatcactgt atacagcaga 3217681 gaggctgaaa tcagcttcag cacctccggc cattcagcgc gcacaaaacc gcctttccct 3217741 ctcgcctgtt tataggactt cgctttttca gggttttcga cgatcgattt ccaggcttcc 3217801 aatggatttt gatgcgtctg caatgcctcc cgccacaaat tgatcagcac accgcgcacg 3217861 tatggatatt tcacacggag cgggctgtag atataccatg aaaaactggc cccccgcggg 3217921 cagcctctcg gttcaaaatc aggcatatcc gggcctgttg atggataatt caaattttgc 3217981 ccttcccacg tgactattcc gtttttcaca taaatattcc agctgcaaga ccctgtacag 3218041 ttgacgccgt gggtggagcg aacgactttg tcgtactgcc atctgtttct gtatacattc 3218101 tcccaatcgc gatcctcgcg ggtagtttgg ctatgtttat ttgaatggtg ttcgatagga 3218161 gagaaataat tcaatctcct aaacaacgga ctccttttct ttttcttcat gagagttcac 3218221 tccttccgag tcaggtgatg ctaagttcac tataaacaga gacagcgtgt ttccttgtga 3218281 actatgtcac acactctgct tttttcacaa aatgttcaca caaaggagaa ggaaggctgc 3218341 gttcaggcag gacgcttggg tcattagctg cctttcattc aaagatcaaa aaaaaccggc 3218401 tctatttaag aaccgggctc agcgttttca tcctgtgatg tatgcagata ccgcaaaaat 3218461 aattgatagg aacaaaaaac attttgctga agcatagcca aaaagttcat ttgcagctgc 3218521 ggatgataag acatcatttt cttaaatatg taatatggga tgttgagaat cagaatgtct 3218581 gaagtggcat tgactgagat aaagggcgat aaataaagcc cgcctttttc atcaatcgga 3218641 aacacatcgc ctttttccca cagcgcaacg gttttcgacc cttcagggag ccttgtgtcc 3218701 ataaaacgga cactgccttt taatacaata taaacagatt gagaatgaag aaaagatgga 3218761 gactgatcac atgaaccgcg gataaacgtg ccgtttttca gcaaggtttc gacaatggat 3218821 agaggcactt cattaaacat aggaagttgt ttcagaaata ataaatagtc acactgattc 3218881 ataggaaaac ctcctgtgct aaggatagct ttagtgtagc tcgactgagc ctgtacagca 3218941 gtgatgtatt tcacagcctg tatgatgaat gtcacttatc aggagggtga atgcatttat 3219001 aatgaaagaa aaaaggagga tttcgatgaa ggcgctgatt ccgaagcagc acggggcgtg 3219061 ggcgatgctg ctgatcccat ttttactcgg catggtcaag ggaggccccg ttatttggca 3219121 tattccgctc ttccttggtt ggcttttcct atacttagcg gtttatcccg ttacgcttgc 3219181 cttaaaaaag aaacaaagca aaccatatca aaagtggatg tgttattacg gttttcccac 3219241 ctgctgcttt ttgatgatct cggtctttca taagccgcct ctcatctggg tgggcgtttc 3219301 tttactgccg ctgtttctca tacatatgta ttttgcccgc agaaaaaacg aacgagcctt 3219361 attgaatgat gttgcaggtg tcttgttctt ttgttcgggc gggtttgcga gctgctggct 3219421 ggggatggga acccttgacg gctgggcttg gtttattttc ttgcagtctg ctttattttt 3219481 tatcgggagt tccttttatg tgaaatcggt gatccgcgag agaaaaaaca gggcatttgc 3219541 atactggtca tggggatatc acctgctgct ccccttttta tccgctcttt tcggagcagg 3219601 atgggcgttt ctcgctttta tcccgagcag cttgcgggca tggttttttc atggaaggga 3219661 ttggcccgta aaaacgattg gcattctgga aatcgtgaat gcctgcttct ttcttgccgt 3219721 catgtgcctg tttatcacaa ggtaaaaaaa caaggacacc gctgtccttg tttttttcag 3219781 tcaatattgc aaatctccag cgggcaattt tcacactcaa tctcacatcg taaatagtcc 3219841 cgcttgtgca aaataatttt tccggattcg tctatcgaaa taaccccttt tttgcggaga 3219901 tctccgagca tacgattgac gctttcccgt gcagccgcgc aaaactttgc caaatcctga 3219961 tttgtcagga caatgttaat cagaatgccg tcgcttcgct ccactccgta gctgtttgat 3220021 aagcggataa gggtagaata gagcgccccc tttttgccat gaagaagcag atccctgatt 3220081 ttggactgaa tcttccggag gtgcgtgctc atccatttca tgaactcaaa tgtcaaagcg 3220141 ccgttttgga ttaattcttt ttccagctta tttttattaa tgacgagcac ctcgccatcc 3220201 tctagtactt ttgcactgag catatacctt ggttcttcag tgaaaagtgt taattctccg 3220261 acgatatcat gcttttggca gattctaagc gtcaggtctt ttccgtcaga tgtcagcttg 3220321 ccgatttcaa tgagtcctga ttgaatcaga taaagctctt ctgcatccat tccttcccga 3220381 aacaaatacg tgtgtttttc catttttctt ttcgtgctga tcgattccag caattcatac 3220441 agatcgctgg atataagatc actatcagat ggtcgaacag agagaaaatt catgagctca 3220501 cctcgaagaa agtcacgttg tgtgtttatt gtaacgtgaa ttgatttgta cccatcgaga 3220561 aaaaactaac aatcttgtga atgccccagt gttagttgat gctctggctg tttctctccg 3220621 tgtgtgtttt cattctttcc tgccaataca tccatatgac aaggacaaaa ctggctaacg 3220681 ccacctctga aagcgccata aacccgatcg cgtactggcc tgttgcctga aatacactcg 3220741 ccaatatgag cggaggaaaa aagccgccta aaccgcccat ggcagacaca atcccattgg 3220801 caatccccgc ttgcttcgaa aaatagaaag gcaccagttt aaaaacagtt ccgtttccta 3220861 tgcctgagca gacggccacg gttaatgatc caaacgtata aaggccgatt gtcggcgaga 3220921 acgataggat aatgcctgat aatgtaagcc cggcaaaaac aaacatcaag atgcggagcg 3220981 ggctcatttt atcagccagg aatccgcccg caggcctgag cagcgtagaa accgcaataa 3221041 agccagccgt ccgcaagccg gcatctgcag gattcagccc aaaatgctcc accagaaagt 3221101 tcggcagata gatagtgaag gcgacaaagg caccgaacgt aataaaataa aacaggctca 3221161 gaaaccatag cacatgattt cggtaaacag ctttgatttg agtcttaaca gaaactttga 3221221 ccttcttctc atgcctgtcg ccaaacaata cgtgcagtaa ggcaaagaca gccagcaaaa 3221281 tcagatacat ttgcacggtt gatttccacc cgacggcttg agcgataacc ggcgctgcaa 3221341 atgtcgtaac ggctgtcccg atatttcctg caccgtaaat cccattgacg acaccgtgct 3221401 tttctttcgg ataatatttc gggagggagg tcaccccaat ggaaaacacc gctcccccga 3221461 tccctaagaa aaagccgcct gcgattaaat caaacagaga atccgcgata ctgatccaaa 3221521 atacaggaaa taaaagcagg atgaagctga ccataaacat gagccgcgcg ccaaacctgt 3221581 tcgttaaata ccctaaagga atgcggagaa gcgacccgag gatcacagga atcgcggtca 3221641 ctaaagaaat ctcacccttg cttaaatgaa tatctaatgt gatttgggaa atgagtgatg 3221701 aaatcagcac ccaaaccata aaccctgcca ccaagcttaa tgactgtaac gataattgaa 3221761 tgtgttgacg gttgatcatt tggcttgccc ctttcaatga ttcaataatc agtcttatca 3221821 tacaaaaact agccaaacag gattgtgaat tacatcacac gtttttctca taaaaaaagg 3221881 acaaagcccg aagactttgt ccttttgatc gtgattacat tttttccgga gccgatacgc 3221941 cgatcagctg aagcgcattg ttcagcgtaa tttgcgttgc cttcattaaa gccaggcgcg 3222001 cgcggctttt ctcttcattt tcagggtcga tgactttctc tgcgttgtag aagctgtgca 3222061 gagcagaagc cagatcataa atatagttag tgacacggtg cggaattcgt ttttccgctg 3222121 cttccgccac tgcctctggg aagccgccga tcgttttcag cagatcgtat tctttttctg 3222181 attgaatatg gctgaaatca agatctgccg ccggtttaag cccctgctct tccccttggc 3222241 gaagcatgct gcaaatacgg gcatgcgcgt attgtgcata atacacaggg ttttcgttag 3222301 atgttgatac agcaagatct aagtcaaaat ccatatgggt gtctgcactt cgcattgcaa 3222361 agaagtaacg cacggcatcc aagccgactt cttcaatcag gtcacgcatc gttacggctt 3222421 taccggtccg tttgctcatt ttcattttct cgccgttttt gtaaaggtga acgagctgaa 3222481 tgatttctac ttcaagcgtt cctttttcat agcccagcgc ttcgattgcc gctttcatac 3222541 gcgggatgta gccgtggtga tcggcgcccc aaacgttgat cagcttatca aagccgcggt 3222601 caagcttgtc cttatgatac gcgatatcag gaagaaggta cgtgtacgtg ccgtccttct 3222661 tgatcaatac gcggtcttta tcatcgccga aagtcgtgga acggaaccaa gtcgcgccgt 3222721 cttcttcata gacgtggcct ttttcgcgga gcgcttcaag cgccttgtcg atttttccat 3222781 tttggtacag tgaagtttct gaataccaca catcaaacgg cacacggaag ttttccaagt 3222841 ccttgcgaag cttttccagc tcgtatttca ggccgtattc acggaaaaac gcgaggcgtt 3222901 cactttcctc ttcgttaacg aaacgatcac cgtattcctc agcgagacgc tttccgatcg 3222961 caatgatatc ctcaccgcgg tagccatcct ccggcatcgg tttttccaat ccgagtgctt 3223021 caaagtaacg gacttcaaca gaaagcgcca gattgttgat ttggtttccc gcatcgttaa 3223081 tgtagtattc gcggcttaca tcgtaacccg cttttgaaag cacgttgcac aaggaatcgc 3223141 cgacagccgc cccgcgcgca tgcccgaggt gaaggtctcc cgtcggattc gctgatacga 3223201 attctacctg aactcgttca ccgtttccga tgttcgtttc cccgtatgct tcccctgctt 3223261 ccagtacaga cggaatcagc tttgttaaat attgattgtt catatagaaa ttgataaaac 3223321 ccgggccggc gatatccagt ttttcaatcg aagccttccc tttatcaaaa tgggcgacaa 3223381 tctcttcagc gatttgacgc ggcgcttttt ttgccactct tgccaactgc atcgccatat 3223441 tcgttgagta gtcgccgtgt gttttatctt tcggtgtttc taaaacaaca ttgggaatct 3223501 ggctttcttc agccagtccc gctttcagaa cggccgcttt gatttcttct ttcagcacgt 3223561 ccttcatttg ttccgcaatg ttcatgcgtg agttcctccc tcatacgtga tcgtcatatt 3223621 atgtaaatgc tcctgctcgt ctccgacatg catgtcatat gcgatgctga tacggccttt 3223681 ttcttcatcg agatcagatt gaatcgattt tgtgcttgtt ttcagctcaa gctcaccaaa 3223741 tgacatttta tatttagcaa ttgtggaagc tcccgttacg aaacgctgat tcattttgac 3223801 agcgcctgac ctcatgacca ggacttcgcc ttcgcttact ttcacaatcg ttttgacttt 3223861 gcctaagtcg tgttcttcat aataagatag atacacttta ttttgtttta catagtaaaa 3223921 tccggtggtg cggaattcga tgacttcttg gtttccgtca tcctcgatca cagacttcac 3223981 atggagtgtt atcggtgtct cttgcttcat tctgacacgt ccttttcatc attccacttt 3224041 gacttgaata gtataatcat tcggtttgta aacttcaact gcttctatct taccatcatt 3224101 gctcatcaga tttgaagata aacctcataa aaagcatttc cttatataga agagaaaatc 3224161 atatcactaa ttacctttag gaaatgttac gagctcgcta catcgcaatc gcagacggac 3224221 ccgcgccaac cggaatcacc gtcacggctg tataatcact tgtgcggtac acggtcacag 3224281 cattgtcgtt gggctgtgcc gcataaatat actgtttgtc cggcgttacg gcgaggtcaa 3224341 aggcgccggg gagagacacg tttgcaatga tcctctgtct ggccgtatta actacgtata 3224401 agttattaat gagaaacggt tcactatatg gctctagaaa ataagctcta gtactatcga 3224461 gagaaaatac aatcgtcctc agcgtttcaa ataaacggct gaagtcccct cccctgctta 3224521 atggtgacaa actaatctcc gttacacctt tcggccacag ctcaccattc aatacgtacg 3224581 caaaatttcc agcgtaagga gttgtaatta aactgggaaa ttcaaatgta tctatgatac 3224641 tttctaccaa ctgcccagta tttacatcat atttatcaac cgaccaactg cttccattag 3224701 cggtatagac atactgtcca ttcggatcaa gagcaaagtc taaagcgccg ggtatcggaa 3224761 tgacatcaat gaccgattga gaggccgtgt taatcacata tatagatccg gcggccatca 3224821 cgtatgcgaa ctcatctgtt ggatcaaatt cgatttttct cggccctcct ccaacagtaa 3224881 tggtatttat gatggttaat gttttattat caatcactga gacaaggttg gtatttccat 3224941 ggaggacata cgtgaatgct ttatcgaaag taacgcctag attagttggc acgtcagaaa 3225001 aagggattgt ttttacaaca gtgtttaaat ctgcatcaat aaccgaaacc gtgctgtctc 3225061 cagtattggc agtaaacaca tacgattgag ggtctggtga tggcggtaaa acaagtgtcc 3225121 cggccaccgt aagcggactg ccgtagaaag gcggtacaat gagcagatct tccactgtta 3225181 tttgactgaa atcaggacag cggccagact gtgctgcata ataaacaact tgatcaatct 3225241 cttcagtatg aatcacagaa acagccccgt ctccttgtcc atattgattt cgtacaggcg 3225301 acacactgac aagaagcgta atggtccctt gtactctcac agcatatcga acaccgatat 3225361 cttctggttc cggcccagtc tggattaagc aaggctcact gatacaggac aaattgtctg 3225421 tactccatgt aacagccgct gacgcttcgg ccgtatcaac cttgaagccc tcagggaaat 3225481 ctatcggcac ttgaaacggc gcttcccggc taatttcctc atcacaaaaa cagaaacaat 3225541 tttcctgtaa agcagaaaga tcattctttt tcatgatttc acgtcctttt agaaatgcac 3225601 aacatgcagc ggttaaatcg taatggcacc cggtgaaacc ccaagagata tcacagtttc 3225661 ctcagaataa tcatctgtgt tgtaaacaat gatgctctgc tctataaaac gagttgcata 3225721 cagaaaatcg ccattcgggg taaacgcata gtctgttgct gattgcggaa catttcctat 3225781 aacgcctgct ccatttggac tgacagaata taaattgcca gtgaagccgt catataaata 3225841 cacctctgct ccactcgtaa acattcgata ttccccttca tactccagct cttgggtgct 3225901 gctgatggta aacgtattta aatcaataac cgtcaaataa ttaaaaaaga attcttgttc 3225961 taatacatag gcataccgct ccggccaatt tgtttctatg gttgatacga taagctctcg 3226021 ttcaattgtt cctgtgactt caccggtagt taggtccact ttttgcacta ttccaaaatt 3226081 cagaacatag gcgaataacc cattgggatc gattgcaaca tcatatcctt ccacaggaat 3226141 cgacctatcc acagttaacg tatcaattcc aatcacataa accgcagtac cggtgaaaac 3226201 ataagcaaac tcatgattag ggataaatct aatcaatcga ggcggctgat ccagcaatat 3226261 agttgctgtc actgttaatg tgtcataatc gatgacagaa atcacattat tgttgggatg 3226321 taagacaaac acagcgcttt tatctggcgt aatttcaata cctgccggat tgtacggaag 3226381 agcaatcgtt gtcacaacag tatcggtgtt tgtatcaatc acagaaactg attgatcatt 3226441 tggattcgct gtaaacgcgt agacgggttc cggctccggt acaagcacaa ttgtccccgt 3226501 caccgataaa ggactgccgt aaaacggcgg aacaacaaca aggttctcaa tcgtgatgtc 3226561 actgatatcc gggcaatcat ccgattcatc ggaataatag acgacttgat cgatttctgc 3226621 attgtgaatg acggaaacag ccccgtcccc ttgtccatat tgatttcgga caggtgagac 3226681 actgacgagt agcgtaacgg ttccctgcag gcgcactgca aattgaacac cgacctcatc 3226741 aggctcaggc cccgtttgaa ttaagcaacg gtcactgaca caagaaaggc tgtctgcatt 3226801 ccacgtcacg tttgcaacag cttcagccgg atcaacgaca aacccttcag gtaattcaat 3226861 cggtgcttga aacatggctt ctcggcttgc ttctccctca caaaaacata agcactcttc 3226921 ttgttctgct cctgcttttt ctttaaagga aagcttgttt tttctcattc cttcacttcc 3226981 ttttcagaca tacactgctc acgcagatat aacagaatat ggaagggtaa cgtgtttgct 3227041 tgtacaaatt gctgagggta aacgcttctt tttgaaaata tatctccaaa catgcggtgt 3227101 aacgaaagaa aaaattgcgg tttttttgcg cttctcacaa gaatgttgat gataaaatat 3227161 gacatatata gaattatgaa gggagggatt tgcaaacgtg acaggtgtca tatcttcttc 3227221 ttccatcgga gaaaagatta acgaatggta tatgtacata cgccgattca gcatacccga 3227281 tgcagaatat ttgcgacgag aaatcaagca agagctggat caaatggaag aagatcaaga 3227341 ccttcatttg tactattcac tgatggagtt tcggcacaac ctaatgcttg agtaccttga 3227401 accgttagaa aaaatgagga ttgaggaaca gccgagactg tctgatctgc tgcttgagat 3227461 tgataaaaaa caggctcgtt taactggtct gcttgagtac tattttaact tcttcagagg 3227521 catgtacgag ctggaccagc gggaatatct gtcggctatt aaatttttca aaaaggccga 3227581 aagcaagctg atattcgtta aggatcggat agagaaagct gagtttttct ttaagatgtc 3227641 tgaatcttat tactatatga aacaaacgta tttttcaatg gactatgcac ggcaagcata 3227701 tgaaatatac aaagaacatg aagcttataa tataagattg ctgcagtgtc attctttatt 3227761 tgccaccaat tttttagatt taaaacagta tgaggatgcc atctcacatt ttcaaaaagc 3227821 ttattctatg gcagaagctg aaaagcagcc ccaattaatg gggagaactt tgtacaatat 3227881 cgggctttgt aaaaacagcc aaagccaata tgaggatgcc ataccttatt tcaaaagagc 3227941 aatagctgtt tttgaagaat caaatattct tccttcctta cctcaagcgt attttttaat 3228001 tacacagatc cattataaat taggaaaaat agataaagct catgaatatc atagtaaggg 3228061 aatggcttat tcacaaaagg ccggagatgt aatatattta tcagagtttg aatttttgaa 3228121 atctttatac ttatcaggcc cggatgaaga agcaattcaa ggattttttg attttctcga 3228181 aagtaaaatg ttgtatgctg atcttgaaga tttcgctatt gatgtggcaa aatattatca 3228241 tgaacgtaaa aattttcaaa aagcttctgc ttattttttg aaggtggaac aagtaaggca 3228301 acttattcaa ggaggagtga gtttgtatga aattgaagtc taaactatta ctctcttgtc 3228361 tggctctaag cactgtgttc gtggcaacaa ctattgcaaa tgcacctaca caccaaattg 3228421 aagttgcaca acgaggaatg atttaaccgc cgtccatcgg cggttttttc gtcccctctt 3228481 taccaaagtc tcccaatcca tgctatgatc ttttcaataa tcttgaagag agtggaaatg 3228541 cagcatgtct ctaaaaagtg tgagaaccca ctttactcaa tggaatcgag aaaatgatgt 3228601 gacggagttc gaaacgtcga gtgcgacagt tgaacaggca gctgagacaa tcggcgtaag 3228661 cctgtctaga atcgccaagt ccctgtcctt cagaggggaa ggagatcagg tgattctgat 3228721 tgtggcagcc ggcgatgcca agatcgacaa caaaaagtcc aggcaaacat ttggctttaa 3228781 agcaagaatg ctctctccta atgaggtgct ggagcagaca ggccatgaaa ttggaggagt 3228841 ttgcccattt ggattggctc atgatcctga ggtttatctt gatgtatcgc tgaaacggtt 3228901 tcagactgtt ttccccgcat gcggcagcag aaactccgct attgaattaa caccgaaaga 3228961 attatccgaa ttttctttct caaaagtgtg gattgatgtt tgtaaagact gggaataaaa 3229021 aaacatccag acatcgtctg gatgtttact tatttcacaa acccaagcag catttcacgg 3229081 atgattttgc tggctgtgtt tgccgtttgc tctgagtggt cgtataccgg cgcgacttcc 3229141 actaaatcag cgccctttac gtttacctct gaacgcgcaa tttcatggac cgatgcaagc 3229201 agttctttag acgtgatgcc gccggcgtca accgttcctg tacccggtgc gtgtgcaggg 3229261 tctaatacgt caatgtcaat tgtgacataa accggacggc ccgccagctt cggaagcacc 3229321 tctttcagcg gttcaagcac ttcaaatttt gagatgtgca tgccgttttc cttcgcccat 3229381 tcaaactctt ctttcatgcc ggaacggatt ccgaatgaat acacattgtg cggtccgatc 3229441 aattctgccg ccttacggat cggcgtggag tgagaaagcg gttctccctc ataatcaaca 3229501 cgaagatctg tatgtgcgtc aaaatggata atcgcaaggt ctgggtattt cttgtacatc 3229561 gctttaatga caggccatga cacgaggtgc tccccgccca tacccattgg gaacttccct 3229621 ttttctaaaa tgctgtccac gtactcttca atcatatcca ggcttcgctg cggatttccg 3229681 aacggcagcg gaatgtcgcc agcgtcaaag aagttcaagt cagccagatc gcggtctaaa 3229741 tatgggctgt attcctcaag gccgattgac acctcacgga ttctgcttgg accaaagcgt 3229801 gagcccgggc gatagctgac tgtccagtcc atcggcatgc cgtaaagaat ggcgtccgcc 3229861 tcttcccact cgggacggct cgcgataaat acttttcctg aataagcttc atcaaatctc 3229921 atctataata ccctcgcttt cctgtaaaaa agcgcaagat tcgctcctgc gccatacctt 3229981 cattatttaa tcaggtcact cacaaatttc ggcagaacaa acgccgcttt atgaatatct 3230041 tttgtgtaat atttcgtctc aatatcgaag aaacggctgt cttccactgc aagcggatca 3230101 tattttttcg agccaattgt aaatgtccac aaaccgcttg gatatgtcgg aatgttcgcc 3230161 gtatacagct tcgtaatcgg gaagatttcc ttcacgtcgc gctgtacatt tgtgattaat 3230221 tccggtgtaa accatgggtt gtccgtctgc gcaacgaaaa taccgtcttc tttcagcgct 3230281 tttgcgattc ctgcgtagaa tccttttgta aacaggttta cagccggtcc gactggttca 3230341 gtcgaatcta ccatgatgac gtcatattga ttttcagatt ttgcaatgtg cataaatccg 3230401 tcatctacct gcacgtcaac gcgcggatca tccagtttgc ctgcgataga aggaaggaac 3230461 tttttagagt attcgataac cttgccgtca atatctacaa gtgtcgcttt tttcacgctt 3230521 gggtgcttca ggatttctct gataacgccg ccgtcaccgc cgccgactac gagaacgtgc 3230581 tccggatttg ggtgcgtgaa taatgggaca tgcgccacca tttcgtgata aacgaattcg 3230641 tctttttcag atgtcatcac catgccgtcc aaaaaaagca tgttgccgaa ctcttctgtt 3230701 tccaccattt ctaaatgctg aaactccgtt tgttctgtat gtaacgtctt gttaaccttc 3230761 atcgtaatgc caaagttttt cgtctgcttc tctgtgtacc aaagttcgct caattgtcat 3230821 ctccctttcg aggctgtatt catttattgt aagcgtctta tcagctttta ttctcggttg 3230881 aaatctcatt ttcacctaag gaaaaagtat agaggatggc ggggaaaaag taaagatgcg 3230941 tcctgttctg cgatgtttaa aaacgatctt tttttctcat aatagtagaa acataaaaaa 3231001 agggggaacc cgttgtggat gcaatgacaa ataaacggct gagactgacg ctgaaaaccg 3231061 ttcgcgcctt tatcttttta ggggcttttg cggccttggc ggcagctgct gtgtttatga 3231121 ctgtcatttt gatagccaaa taccagggcg ctccctcggt gcaagtgccg caatccacga 3231181 ttttgtacgc gagtgacggc tcaaagctcg gggaaacgaa ctacggcgaa aagcgctatt 3231241 gggtcccctt aaaggacatg aatccgacga tcgtaaaagc gacagtggcg attgaagacc 3231301 agaatttcta cgatcatcac ggctttgatt ataaacgcat ggccggcgcg gcgcttgctg 3231361 acctgaaagc atttgccaag gttcagggtg caagcaccat cacccagcaa tatgcgagaa 3231421 acttatacct tgaacacgac aaaacgtgga aacggaaatg gaatgaggcg ttctacacga 3231481 tccgtctgga acaaaactat tctaaggacg agatattaga aggctattta aatacgattt 3231541 actacggcca cggcgcctac ggcattgaag cagcttcccg cctgtatttc ggcaagcatg 3231601 ccaaaaacct gacggatgcg gaggcggcgc ttttggcagg aatcccgaaa ggcccttccg 3231661 gctattcacc gtatgtcaat gagacgaagg ccaaggaacg ccagaaaacg attgtgcgga 3231721 tgatggaaaa gcagcagatg atcagccaaa agaaagcgga tgaattgatc aaggaacctc 3231781 tttcctatca gcctttgaat aaacaagttt ccaagagaaa ggctccttat ttctacgaca 3231841 atgcgatgag agagctggaa aaaaagctcg gcatgacacg ggagcaaatt gaaacgagcg 3231901 ggttaaacgt ctatacaacg gtagataaac ggatgcagcg catcgccgag gagaccatta 3231961 ccgaaacggt taacgcgggc tctgacattc aagtcgggtt ttcagccatt gatccccgca 3232021 ccggaaacgt tctcgccctt gtcggcggca gggattatca aaaaagcccg tttgaccgga 3232081 cgacacaggc gaagcgccag cctgcttcga cgatcaagcc gttgctgtac tataaagcga 3232141 ttcagagcgg atttacgcca gtcactttga tgaaaagcga agaaaccgag tttcaaattg 3232201 atgcaaaggg agaaacctat tctccaagca actataacgg atactatgcc aacaagccga 3232261 ttacgcttct gcaggcgctg gcgctttccg acaatattta cgctgtgaaa acgcatcttt 3232321 ttctcggcac gaacaaactt gtaaagacgg caaaggaatt cggcattacc gcccatcttc 3232381 aagcactgcc gtccctggca ctcggcaccg aacccgtacg tccgattgag atggtcaacg 3232441 cctatgccat gctcgcaaat ggcggaaaga aaatcgaacc gacttttatt tcaagagtaa 3232501 cggacgcagc cggccacgtg ctgtacgaaa acccgaatca gcataaacag gtgcttgatg 3232561 aaaaagccgc ttttgtcaca gcgagtatga tgacaggcat gtttgatatc gatttaaatg 3232621 gatatacgtc ggttacgggg cgaacgatag ccaaccgcct gacaagaacg tatgccggaa 3232681 aatcaggaac caccagcgca gacagctgga tgatcggctt caatccgaag ctggccgccg 3232741 gtgtttggac cggctatgac aaaaacagca ccatcgactc ggtcgaagaa aaaagctatg 3232801 ctaaaaccat ttgggcggac ttcatggagg acgcgctcaa aggcgaaccg gaaaccgcgt 3232861 tcaagccgcc aaaaggcgta accggtgtgt acattgatcc ggaaacaggc tactcatcag 3232921 gtcccggctg cgccgctaag cattacacat attttgtgaa agggacagaa cccgcaaacg 3232981 tgtgctacgg ggcagaaccc gcaaaacaaa caaaagaccg gcttccatcc aaagaaaagc 3233041 ccgcttccga gaaaaagtgg tgggacaaat ggctggggcg acatcattga aaataacccg 3233101 gctcctcgga ggccgggtta ttcgtatggt tccttcataa tcgatggaag aatgttagac 3233161 aatcgagctg aacaatcagt tttgggataa agtggtgaat ttctcatttc ttcggcgctg 3233221 gctttcatct cccagtcgcc gactcatatc cccctaaaaa tgaaaaaccc cgagtcttgt 3233281 ttcggctcgg gattttccat gtcctatttc tgtatcacca gtttactcaa tgtttacgaa 3233341 aaatatctca aatactttaa aagttcacaa aaaattcata aattaattgt tttctggaag 3233401 caggctcgtt tttaactcat ctgaggaacg gtcccatagg ccctgatcat gctttttcag 3233461 aaattcgcct agtacacgct tcgagctgtc gtccatttta tcaacgatga ttttccgttt 3233521 catggattta tccatcagat tcacatgctc aggcagtgac ttgtagcctc ttctgatgct 3233581 tctgtcgacc gtcatttcac aggctgtcac accagcgtaa taaggcccct cttcttttct 3233641 gtcaatcgtt acccacacaa gccagtatgg ttttccgttc ggcacttctt ctttattcgg 3233701 gagaaattta attccttttt caacggtgct gcgggcatgc atagcgccga tgtctacgaa 3233761 cgcttctttt tcctctacat caacgaatac gggagaaatg ttatcaaggc tgagtgcccc 3233821 tacgccaaaa ccgccgtgtc cgtctgtcgg atcacttttg ataatattaa acccgattga 3233881 ttttttcttt ttttcttcca tgaagttcta cctcctacaa aagcggttga aatatcgctg 3233941 aaaacagctt taaaatcgaa tctcttcctg cattgagcat cggccacagc acgtaagatc 3234001 ctagcggtgt cacaaacagc accaaaaata cgataaagcc gtagctctcc gcctgcgtca 3234061 ttttggcacg cacgcccggc ggaacgagat cttctataat tcgatagcca tcgagcggag 3234121 gaagcggcag cagattaaat aaaaacaaga caagattcag ctgtatccaa atagaaaaaa 3234181 actgatccag ccccgtgctg aacgccgcaa gcatttccat tccgtacgca tgcatcaaca 3234241 ctaacaaaaa gaaaccaata aacgcaagaa tcaggttact gacgggcccg gctatagata 3234301 cgagcacacc agcaagccgg ggtttcttaa agaaacggcg attcacggga atggggcgcg 3234361 cccacccgaa tccggccacc agaatcaaaa tggttccgaa cggatcaagg tgtttaatgg 3234421 gattcagcgt cagtcttcct tgttttttcg ccgtatcgtc accgaatttg tatgcgacat 3234481 aagcgtgggc aagctcgtgc atcgtaaacg acacaattag cgtgatgacg aggtatggca 3234541 ttaaagataa cggataatat aaaaaacggt ccaagtgaga tatccctctt tctcaaaatg 3234601 caagaattta ctttattcag tatactataa gaagcctctt tttctaaaga gaggaaacga 3234661 gataaaggag gattcagcac ccatgccata cgtaactgtc aaaatgctcg aaggccgtac 3234721 agacgagcaa aaacgcaatc ttgtcgagaa agtaacagaa gccgtaaagg aaacaaccgg 3234781 tgcttctgaa gaaaaaattg ttgtctttat agaagaaatg agaaaagacc attatgccgt 3234841 cgcaggcaaa cgcctgagcg atatggaata atctctataa agccggcgct tcgcgcaccg 3234901 gcttttatta tccctattga gccagcttcg caataatcgc caagaacgtc tttttctctt 3234961 cggctgttaa acgttcaaac atgccatcaa tcagctgctg gcggttttcg atcatttgtt 3235021 cagccgctcc ccggcccgat tcagaaagag taatccatac agtgcggcgg tcattgttat 3235081 ttctggatct ctcaataaac ccttcctgct ctaaatgatt cagagctgtg gtcgtggcag 3235141 agggagacag tgtgacctcc ttcaaaatat cctttatggt gcagctccca tgtctgtata 3235201 tgatccgcag aataaaccct cttacattat tcacgtgttt cggaacggtg gcttcatcta 3235261 attgcttcgt gcttttcaaa tactttgtaa gtgcgtgatc cagcaaattt gcttccagtt 3235321 tgtcatggtc catgtcaatt tccccatttc gagatgcatt cataacatac gaacgatatg 3235381 atttacttat tattttactg attccgaata gggaaagtca aaaaagcaaa atgtgaattc 3235441 acagctttta tcctacatgc ctcgattttc cacctgtttc acaagtttat ctttaaaagt 3235501 ttggaaagga acgtgttcat tctgctgatg tccgaatcgg cggacgttta ccgcattctc 3235561 ctgctcctca tgatctccaa gcaccagcac gtacggaatt ttttgcacct gcgattctct 3235621 gattttatag ccgagcttct cattgcgctc atcaatgccg gctcttatcc ccgcctgctt 3235681 cagctccgcc tgcacttttc tgcaatagtc taagtgaacg tgcgaaaccg gtatgatttg 3235741 aacctggatc ggtgcgagcc agactggaaa agccccaccg taatgctcga tcaaaatgcc 3235801 gaagaaacgg tcgattgagc cgaaaaccgc tctgtggatg acaacgggac gaaccttctc 3235861 attgagttcg ttgatatatg ttaaatcaaa tttttccggc atttgaaaat caagctgaat 3235921 tgtcgcgcat tggtggctcc gtttcagggc atcttttata tggaaatcaa ttttcggccc 3235981 gtaaaacgcc ccatcgcctt cattgatctc ataagagagg ccaagctcct caaggacgcg 3236041 tgctaaggca cgttccgacg cttcccaaag gctgtcatcg cctaatgaat cctccgggcg 3236101 agtcgaaagc tcaacagaat actcgaaacc aaatgtccga tatacctcat caatcagccg 3236161 aatcgcttct ttgatctcac tctcaatctg atcctcccga acgaaaatat gggcgtcatc 3236221 ctgacagaac gtccgaacgc gaagcattcc gtttaaagcg ccgctgtatt catggcggtg 3236281 cacctgtccg aattccgcca tgcgaatcgg cagatcccga taagaataca ggctgttttt 3236341 aaagatgagc atgtggccgg ggcaattcat cggcttcatt gcgaatcttg tatcatccac 3236401 ttctgaaaag tacatattgt cgcgataatg gtcccaatgg cctgactgct cccataaccg 3236461 ctgattcatc ataaacggcg tacgcacctc atcgtagccg gcatttgttt gcagctcacg 3236521 cgagaagcgc tccagctcat tgcggacaat ctgccctttc ggcaaataaa acggcatccc 3236581 cggcgcttct tcagaaaaca taaacagccc taactgtttg ccgagcttgc gatggtctcg 3236641 ttttgccgct tcttctagca tatgcaggtg cgcatccaaa tcttttttct tttgaaacgc 3236701 aaccccgtac acccgctgca ggacttcatt tttgctgtct ccgcgccaat aagcgcctga 3236761 tactcttgtc agtttgaacg ccttgatcat ccctgtagaa ggaagatgcg gccctcggca 3236821 caggtcaacg aattcccctt gctggtacag tgtgatatcc tccccgcgcg gaatatcctt 3236881 taaaatctca agcttgagcc gctcgtcttt ttgtgcaaac agctcttcag cttcttcgta 3236941 agaaacctct atacgtttga tttcaaggtt ctcatttatt atgtttttca tttctttttc 3237001 gatggcctct aagtctcctg atgccaagct tttccccagc ttcatgtcat agtagaagcc 3237061 gtctaaaatc acaggcccta cccccaatga cacttcgccg tacagccgtt ttactgcttg 3237121 ggccagcacg tgcgctgttg tgtggcgaag cacctgcaag ccttcttgtg aatcgagtgt 3237181 gacaatcgaa agctcagcat cctcctccag cttgaaactg agatcaacaa gcttgccgtt 3237241 gacctgacct gcggccgcct tcttttgcag actggaactg atcgaaccag ccgcttcttt 3237301 gattgtgatg cctttcggat attcctggat ctgtccgtcc ggaagctgaa tgtgtacatg 3237361 tttgctcatt ttagaacact ccttattcat tgttgtatat aaaaaaacac acccgtcccg 3237421 cagataggga cgagtgtgtg attaacccgt ggttccaccc aagttcccga caaatactat 3237481 gttgtcggct cggtgctgta acgcagcata gacggcattg gttacttcag ttccccaatg 3237541 ctgctccaag gcggtaaatg atattcctaa gctgggaagc tctcaccttt ccttccctct 3237601 ctgaaaaccg taactatcat tcatgtcctt ttcatcgcat gtattcaatt cataaaaaaa 3237661 cacacccgtc ccacagatag ggacgagtgt gtgattaacc cgtggttcca cccaagttcc 3237721 cgacaaatac tatgttgtcg gctcggtgct gtaacgcagc atagacggca ttggttactt 3237781 cagttcccca atgctgctcc aaggcggtaa atgatattcc taagctggga agctctcacc 3237841 tttccttccc tctctgaaaa ccgtaactat cattcatgtc cttttcttcg catgtattca 3237901 attcaaataa aaaaacacac ccatccctct aaaagggacg aatgtgttga tcatccgtgg 3237961 ttccacccaa attcccgatc aattacacat gatgatcggc ttaaagatgc tgtaacgcag 3238021 catgacggta tcagatactt gttttccctg atacggctca aaggcggtaa gctgctttcc 3238081 ctgcgttagg aagatctcag ctgtccttcc ctctctggaa accgtaaaaa gcatctcgtg 3238141 tccttatcag tgcctgttgt ttcaataatt ttttatatct tactatatat tcccacaaag 3238201 cgcaatcagt gatttacatt ttttctgacg cggcagtccc gttatgggca gccagaaaca 3238261 gccatacaag caatgcagcg aggctgtatg ccgctcccat catcaaaaac gcaaacccgg 3238321 caccagcata ccaagtggcg gacagatgaa tgatcacccc ggttatcgct acgccgacca 3238381 aggctccgat ttgccggttt gcatttaacg ccgcaccggc gatattcgta tgtctttgcc 3238441 cggcagcctg catgatcaca gttgtcatgg caggaactgt aataccggta cagaggttca 3238501 taacagacat caacaccgcc agctgccaat aaggaaaatc cggagaaatc agcacaaaca 3238561 acagcaatgc aatgatacag ctgaccgcca ttgatacaaa cataagctga ccggcttcaa 3238621 accgattcgc cagacgggca aacagcagat tgccgatcac gaagaccgcc atcatcggca 3238681 gcagctccac tccagccata aaggaacttg cccctcctgc ttcctgcaaa aaaaggctga 3238741 gcataaacat gccgccaaaa agggcgaaat tcagcaaaaa cccgataaat tgggcagctg 3238801 agaagcggcc gtttttgtat aaggacgccg gcaggatggg tgtttttgca gaaatttccc 3238861 gcagcaaaaa cagcacaaat gccaaaaccg ctgcagtaaa tgctacaaga atcactggcg 3238921 agcgccagcc cgctgaaggc ccctgtatca aagcatagga aagaaacccg agagccatca 3238981 tgccaagcag atgcccgatg atgttcacgc ggctgctttt cccaggaacg cggctgagga 3239041 ttcggtaagc tgaaatgagc gcagcagccc ctattggcac attgatcaga aaaatactct 3239101 gccagcccgc caactgtacc agcacgcccc cgataaaagg cccaagggct gaagcggcgg 3239161 aaacaagcgc ggcccacagt ccaaacattc tcgcccgcgc ccgctcatca aggtaagagg 3239221 cagccaaaag gctgagtgag cttggcataa acaaagctgc cccaattccc tgtatgagac 3239281 gtccggcaat cagcatctgc ccatttatag atgcagcgca tagacaggag gccataacaa 3239341 aaacggctag acccaagata tagatcgtct tcgagccgaa acggtcagcc aaggctccgc 3239401 ccgccagcag aagcgacgca aaagtaagaa tgtacccgtc cacaacccac gttacacctg 3239461 aaagtgacat tgaaagagtg tttttcatat cagccatcgc cacattcaca acggtcacat 3239521 caagagttgc catgaggaaa ccaagtgcga gcacgatcag cacggatatg cctgttgatg 3239581 atgttgattc ttgtatagac ccgctatttt tcattacaat tgccctttca cttgcttgat 3239641 tacccaatca tctatttttt caagatcata caattccccg actctgtcca taacatgctg 3239701 caaggattct tctctcataa gattggacca tttatcctcg atttccgcca tgactgtctc 3239761 cagcacacag tgactttcac cctcaaatac agattgcagc aagcctttcc cctgatacat 3239821 cgaacctctg ccttcgaccg cttgataaac atcataaagc gtaatgtcag ccaaaggctt 3239881 cgtcagggta aaaccgccct tcgtccctgg taaggattct gccaaaccgg cttgaaccaa 3239941 tgttctcatc agcttcttca agtaagacgg agacacgcgc aatcgctggc ttatagcctc 3240001 tgacgtcaaa gaagcctgta ccggcagccg tgacagtaac agcagcacag aaaccgcctg 3240061 ctccattcct gatttcattt tcatcctatt cactcctgat tcattatgga taactattat 3240121 ccataatgaa tctcttagca gcttttgtca ataaaaaaag caaaagaaac ggatcatttc 3240181 ttttgcttgg tatggttaac aaatctgctt cagttcctct atgtattgaa gcgcttcgtc 3240241 atattcttca tttgtatatt tttgcttgct tttgatggta aagacttttt ctttcttttc 3240301 ctcatcctca agcccgtcaa agtaaaggat cgtggaaacc agctctaaaa accgtgatga 3240361 acggctgttt acactgtcga tatagccttt catatccggc atgtccagat cagcatggtc 3240421 taaaaatgcg gagcctgtct cagtcagcga ataccggtat tgaaagtagc cgcccttttt 3240481 ttccttcacc tcatgcagaa atccaaggtt gcacagctct tcaatctgga gcgtcagttc 3240541 ctctgaatat ggtccgtaaa agtgaaaatc atatttctca tagaaaggaa actgcatttt 3240601 cttggcgata taaatcattt tctgcagctt ctttcgcccg atgatttctc cagaatccga 3240661 gaacaccttc atcagttttg catgttcttt caacaaattc ccgacatctc ctttttcctt 3240721 ctttccaatt tctatgtcag tcccagcagc tgccggattt tcattttcgc ttccggatgt 3240781 ttagtgccgt cacaaatcaa gtcctttgga tagtacagct tgtggtccgt ccgccgttta 3240841 cctgagatgg attccacaat agccgactgt ctggacagct ctttaatttg gccgttttgc 3240901 gtcaagagat ggatcggcag acgctcctct tcctctcctg gtcggtaaaa atcgtatggc 3240961 agatctgatg aagaatcaac gaccaaataa tagctcggat cgatccccgc ctctttgaac 3241021 aatgaagtca gctcaaaata agccgacatt tcttcattcg gattgaattc aacgtattgg 3241081 aaaagctggc ggttaatgaa tctgcggcac aagtcggata aaatcgcgtc ttcttcatcc 3241141 tcccaggcct ggaagtaata caaaataata gattcatcca gctttacata atcctccagt 3241201 gtcaattttc cttcaaaaat agaatagaaa tgaaccggag cgtgagtgaa gacatagcct 3241261 tcatcgtgca gctgcttcgc cctgtgaaga atcttcgtta aaatgacctc tgcacttcta 3241321 gtcacaggat ggaagtagac ctgccagtac atttggtaac ggctcatgat atagtcttcg 3241381 acagcgtgca ttccgctttc tttaatgacg atctgatcct cgcgcggccg catcacccga 3241441 agaatccgct ccatatcaaa atggccgtag ctgacgcccg tataatatgc gtcgcgctgg 3241501 aggtaatcca tgcggtctgc gtcaatctga ctcgaaatca ggctgaccac ttgcttgttt 3241561 ttatatgttt tggcaatgac ttcagcaaca tcctgaggga aacccgggct cacctttctg 3241621 agcacctgat taacctccgt gtctcccaaa atgatacctc ttgtaaaatc ctcgtggtca 3241681 aggtgaaaga ccttttcaaa tgaatgcgag aacggcccgt gcccgaggtc atgaagcagc 3241741 gccgcggcca aacagagttc gcgctcactg tcatcccatt cagggcggcc tttaaagacg 3241801 tcatcaacca ttcttctgac aatttcatag acaccgagag aatggttgaa ccggctgtgc 3241861 tcagccccat ggaacgtcaa ataggtcgtt ccgagctgct taattctgcg gagacgctga 3241921 aattcacggg ttccgatcaa atcccatatc agcttgtccc gaacatgaac atagcggtgc 3241981 accggatctt taaacacttt ttcttctgat aattttccat ttggatacgc catcgtcatt 3242041 ccctcttttt tttagccgtg tttctattat atcgactcta ttctttgaaa acatccttga 3242101 atttgcccgg cgatttgttc catcttcatg aaaaacacat cttgtgaagc aaaaaagcct 3242161 gacctgaggg ccgaggctaa gaaaaaatat gtttttactt ttttattttc ttttttactt 3242221 tgtcaatcag ctcatcctct gtcggagctg acagcgggcg attgttcaca aaagcaaatg 3242281 attttttccg tccgggcccg caataagatt ggcatcctac ctcaaccttt gcgtccgggt 3242341 ccacttcttt caaacgcggc agcaatgttt tgatattagt ggcttggcaa tcatcacaca 3242401 ctcgaaattc attagccatg acgtacgctt cccttcattt ctatgttcat ctatgtgaat 3242461 aacctaaaat cacgtttcaa aaaaaatcac atcacacttc attttacaag gattcgactg 3242521 ttcctgcaag ccgctccatc cttcgtatct cctattcttt cagccaattt gtataaatat 3242581 tttccaacct ggacattcta ataccatgaa aagaaaaatg ggagttgaga taaatgacaa 3242641 aacagcgaca agacgcttgg tcagaggaaa acgatctgct tttagccgaa acagtgcttc 3242701 ggcatgtgag ggagggcagc actcagctga acgcctttga agaagtcggc gataaattaa 3242761 accggacatc cgcagcctgc ggattcagat ggaacgcagt ggtccgccat caatatgaaa 3242821 aagcgcttca gcttgcgaag aaacaacgaa aacagcggat gagagcgctc ggaaacgggc 3242881 agcccgcgaa aaaaagatta ttatatcagc ctcctgccgt tgatcctgaa atcattcaag 3242941 aaaccgctgc agaagagccg gttaaaacgg aaacaccatc tgtcgaaaat gagcaacctt 3243001 taatgtctgg cgaacacatg ccttttgttg atgaaagctt taaggaagag ttagctagtc 3243061 tatcacactt attgtctcct caaacgcctg cagctgcgcc tgagatgacg atgaatgatg 3243121 tgatccgctt cctgcagaat tacgaaggca atcacgagca atcatcagca ttaaaaatgg 3243181 aaaacgagcg tttaaagaaa gaaaatcagg aattgcaaaa caaaacagag cagctagagg 3243241 cagaagttca aaagcttgaa aaagaccaaa aaacgatcca agaagattat gaaaccttgg 3243301 tgaaaattat gaacagagcc agaaagctag ttttatttga agaagatgaa catgcctctc 3243361 cgtccttcaa aatggaccgg aacggcaatt tagaaaaatt agcggaatga catagaaaaa 3243421 tcccaaaacg ggcagctgtt ttgggatttt cgccatgtgc aaaatcccct tttctattga 3243481 gaaaagagaa tttcctcatt ttgcagccgg atcagctatt cttgtaaaat gaggccaagc 3243541 ttatgtgaat ctattaagac atgtgagctg cctcggccgt tttttgtttc cgaggcgcag 3243601 cagaaatgac caaaagcccc agcatcataa gcgcaatgcc cagccacgag gaaggcgaaa 3243661 gcatttcccc tatgaaaaac acgccaagca atgaagccgt cagcggttca gctaaagaca 3243721 gcgtgaccgc cgccgaggcc ggaaccccgg taagcccttt cgcaaacaaa aagtatgcgg 3243781 cacatgttgc aattaacccg atgtaaaggc ttgttcccag tcctctaggg gtcaatatcc 3243841 acgagatatc taactgccat aatagcggcg tcagcaagat ggcgctgatc atgaatacaa 3243901 cggcggaggt cgctcgcgga ggctgggttt tcatcatcgc tttactgatg agcgtatagc 3243961 ctgcaaaaga agcacccgct ccaagcgcca taagaacacc agccacatca atccgaacat 3244021 tggaactgtc ggaaaacaga agccagcaac ccgctaaagc cagcacagtc gcaatccacc 3244081 aggagtttcg cgggcgtttc ttcaatacag cccattcgag ggtcccggca atgataggcg 3244141 cactgccgat ggcaatcaca gttcccactg caattcccgt ttctttaacc gctgtgaaaa 3244201 acagcggctg gtaacacgcc atacaaacag cggctaaaaa tacgagcggc catgcccaat 3244261 ttttcacgtg aagctcccgg ctgatccaaa ccgcaagcag catggcgctt cctcctatta 3244321 ataacctgaa cgctccaaat gccagcggtg tggcgctttc tggagccaat gcctgaacgg 3244381 ttcccgtggt cccccagaaa aaagccgcaa tcaatacaaa aaggctgtaa atattcccct 3244441 tcatctgcct ctccccttta atatggatgc tgatgtcatt ttatcgtttt tctttttgtc 3244501 gtggttatct gtatgtaaga aggacttatc tgaaaataag attattgagg taaaatgccg 3244561 cttgagataa aaaatgcatg ccggcatata cagccggcat gcgaagaacg ttcacccaaa 3244621 tacctttgca ttccgctcag ccatccggac gaggtttttc tcaaattcca tttcctcatc 3244681 aatggacagt ccagctgaat aaagatgggt gcttaacgct tttaattccg tcaataaagc 3244741 gaacattaag tcttgtacgg agatgtcttt ttgaagaagc tcacttaagg acgccatcgt 3244801 ttccggacgt atttccggat agacgccttt tttatcgttt tgtttgtctt tcagcgccgc 3244861 ttgatagaat cgtctgatca agtcggccct ttcactgccg cttttatctg cacagagata 3244921 aatttgaaca gcgactccgc cgcgaacgcg tctctgagag atgccggcga actttttgcc 3244981 atttatactg aggtcatagc tgccgggaca ataagaccct tcaatttcat aggcttcgat 3245041 ctttgcgttg tacggtctca gcattcgtct catcagctcg accatcgctt catatccttt 3245101 gtctatatcg atgcctttct tttcgtcctc gaatatgaga gagatattta aaacaccgtc 3245161 atccaatacg acggcaagac cgccggaatt gcgtacgatc acacggtatc cttcgctctc 3245221 cagcaaggag ataccatcct gcaaaaacgg gaggcgtgta tcctgtattc caaggacaat 3245281 tgtatcgtgg tgcacccatg agcgcgctgt cgccggcgac acgccttttc cgacggacat 3245341 gcatagcgta tcatccattg cgaaggattg cttcgcatca aataaagggc cgagactgga 3245401 ttggtcaatg actctccatt tcggctgcat cagtaaatca atcggttggt ttgccatcta 3245461 tgtaaaaccc tttcatgtta ggcttattga acgaaaacta ttatatcatt tcagcagctg 3245521 tgattgataa ttgcttttca gcatcgtaat aaaaatttct ttattttttg tattctccat 3245581 gagaggagaa tgaatgtaag acagcttgcg ctttaacgag aaattattaa tatgcagaat 3245641 tgaaatttcg cggtggatca aatccttacg cagcacgctt ctggatagaa ccgaaagtcc 3245701 catgccgtta atcaccgctt cctttacacc ttgattgctg ctgatggtaa acattgattt 3245761 cggccgaagt ccatttgaac tgagtacatg atcgagatat tctctcgtcc cggagccttt 3245821 ctctcttgtc acccacgctt cgttctgcaa atcgctgatc gaaatctctt tccgcccggc 3245881 gagcggatgc tgatttggag cggcaatgca catttcatcc tccatgaacg gttcaatttc 3245941 cagctcattc tcgtttgtat gtccttcaat cagcccgata tcagcctgaa gcatccgcac 3246001 acgctcgctg acctcctctg tattgccaat catgacatct agattcagct ctggatacag 3246061 cttttgcagc tgggccaata gcggcggaag aatatactca ccgattgtaa agcttgcagc 3246121 tattttcaat tcacccttca catagtgatg atgcgcatag atttcagcct tggcttgttc 3246181 gtagagaaac accatttgct ttgctctttg atataaaatg tctcctgtcg gcgttgtcgt 3246241 aaagtgtttt ggcgacctgt tcagaagagc cgtttgaaat tctttctcaa gatttttgat 3246301 atgcagactg acgctgggct gggagatcat cagcttttcc gccgcttttg tgaagttttt 3246361 ttcttctacc accgctataa acgttttcag cacgtcgtaa tacaaaaacc ccacccctgt 3246421 cattaatgaa atatatggtt atgattagtt ttctttattg tactcatatc atccgtcttg 3246481 gtaaagaagg gctatacaga agcgcaaaaa aggcagccct cggtcgagag ctgccattgt 3246541 cttcaatttt attacagtgc ttgcgccgct gtaattaatg cgagattgta aacatcttca 3246601 gcgttacatc ctcttgaaag gtcgtttaca ggcatattta aaccttgcag gattggtcct 3246661 accgcttcaa agttgcccaa acgctgagcg attttatagc cgatgtttcc tgcttcaaga 3246721 cttgggaata cgaatacgtt agcgtcccct ttgatctcgg aatccggcgc ttttttctca 3246781 gctacagatg gaacaaatgc agcatcaaat tggaattcgc cgtcaagtgt cagttcaggc 3246841 gctttttctt tcgcgatttt cactgcatcc gctacttttt ctgtttcatc agattttgct 3246901 gagccttttg tagagaagct gagcattgcc acgcgaggct caatgtcgaa catttttgcc 3246961 gtattggcac tttcgatcgc aatctcggca agatcttggc tgtcaggtgc aatgttgatc 3247021 gcgcaatctg cgaatacgta ttgctcttct ccgcgagcca tgatgaacac gcctgaagtc 3247081 tttttcacgc cttcttttgt tttgatgatt tgaagagccg ggcggacagt gtcagcagtt 3247141 gagtgagcag ctccgcttac aagtccgtct gcaagtcctt tatacaccag cattgtaccg 3247201 aagtagttct cgtctaataa tgctttacga gcctgttctt cagtcgcttt gcctttgcgg 3247261 cgttctacga atgcttgtac aaggtcttcc atgccttcat atgtatgagg atcataaatc 3247321 ttaacgccgc ccagcgtaag gttcaattct tttgcttttg cttggatctc attttcattg 3247381 ccgatcacaa tcggattcag cactttgttt cctgcaagct tgctgaccgc ttctaaaata 3247441 cgctcgtcta agccttcagg aaatacaatt ttaacgtctt ttccagctac tttttcttgc 3247501 actgttgaaa ataaatctgc cacaataaaa cctcctcaaa aagttacaaa aacgctttct 3247561 tttactagca tactcttctt ccaatcaaat tcaaacagcc aactttcatt atagcgcttt 3247621 cataaaaaaa tcttattttt ctaactaatt taagtgactc aatcttccct tataggttct 3247681 tctattttga tggagttata cggaagggat gttcaaggtt tctccacagt agaatcggat 3247741 aaactatggt atagtgaagg caatcatgaa aagataatgg gagtgaagat aaatgagtga 3247801 acagcaaatg acgaatgaag cggcaaaaac gcttgacggc tggtatgcgc ttcatgattt 3247861 ccgcacaatg gattgggctt cctggaagct tctgtccagt gatgagcgcc aatctatcat 3247921 acatgaattc accgggttgc ttgaaaaatg gggcgtagcc caaaaagaag gaaaaggatc 3247981 gcaaactctt tacagcatcg tcggccaaaa agctgatttt atgctgatga tccttcgtcc 3248041 tacaatggaa gaattaaatc aaattgagct tgaattcaac aaatcaagac ttgctgagtt 3248101 caccattccg gcatactcct acgtatcagt ggtagagctg agcaactact tggcaagcgg 3248161 tgacggcgat ccttatgaaa atccgcatgt gcgcgctcgc ctttaccctg aactgccgga 3248221 atctaaatat gtatgcttct atccaatgga taaaagaaga tctggcaacg acaactggta 3248281 tatgctttca atggaagaac gcagaaactt gatgagaagc cacggtttaa tcggccgcag 3248341 ctatgcgggc aaagtcaaac agatcatcac cggctctgtc ggctttgacg attacgagtg 3248401 gggcgttaca ttatttagcg atgatgtcct tcaattcaag aagctagtgt acgaaatgcg 3248461 ttttgacgaa gtcagcgctc gctatggcga atttggttca ttctttgtcg gcaatcacct 3248521 ttcgcttgat acacttcctc aattcttata tgtataatat ccccgagctc gtttattgag 3248581 ataaggactg atcggccttc tgctcaagtt tgccgtactt tttatatgcg aatacactga 3248641 gcacaaatcc gaggactgtg atggcggcgc aaatcaatcc gacagctgca tagccgtatg 3248701 ccacatatac gggtcccatt aaagcagaac ctaatgtcac ggccagattc gaggcgagac 3248761 tgtaaaacac catgactttt cctcgatgac gctctgagca gtcactcaaa atggtgctga 3248821 gcagcgtcac cgtcaaactt tgcattaatc cccaaataaa taggctggcg attaacagaa 3248881 acatagacgc cggcgcatat ggtaaacacg ccagcagaac gctgatgacc cccagcgcaa 3248941 tcaaaaggga gcgcattttt ccgatgcggt cggctatctt tcctgtaatc acactcatgg 3249001 aaaacccgat tccataaatc atgataaata agcccgcagc cgtgtttcct ccggtaaaaa 3249061 cgtcctgaag ataggtgcct aaaaaggaat acataccgta aaaaccaatc atattacaaa 3249121 aggttattgt gatataaaca ggtacacgag ggactttcag cgcatcccgg aatgttcctg 3249181 cgggctcttc tatttcttcc ttgccgctgt ttttatgttg ggcatggcgg cgcatttcaa 3249241 ggagaatcag cagaacaact aaaacaccca tcagggcgaa aatccaaaac gtccatctcc 3249301 aatgcaggac gccgccgata aatgatccga gcggcactcc gaaaatcagc gccagcgacc 3249361 agcttgaaac gatcagtccc atcaccttgc cccggtatgt ataaggaaca cgatcaccga 3249421 caactgcgta agcggtcgga acaaacgctc ccgcagccaa tcccgaaagc gcccggccta 3249481 aaaagaagaa aaaaatattt tgagctaaag cgcatatcac cgttcctatg ataaaaatca 3249541 taagcccggc caataagctc agttctctgg agtatttatc gcctaatgga accaaaagcg 3249601 gcgcaccgat aaaaatcata acgccgtaaa tactgataga taacgcaagg acgctgacat 3249661 ctgagctgaa ggcttttgct aaatccggca gcagcggtga gatcacaagc tcttcagatc 3249721 cggctgcaaa tacccccatc gttaaagcca gtgccaacaa taacggaaaa tgatgttttg 3249781 ttttgatgtc attgttttga ttgctgttca ttctttctca aacacctctt ccataatctt 3249841 cttatcataa agttgtatta tagtttagca ttgttttttc tctatttaca attcgaacga 3249901 aatatttata agttttatta ttttcattta aatcccatta tatatttcta tatttcattc 3249961 taaaaataca tgaggatgta acacgtaaaa aaagctctcc ggcctcccgg agagcttttt 3250021 ctattgcgcc tctgtctgct ttttttcaat cgtttcatga tttatacgct ttttgatgct 3250081 tagatgatag tatgcataac agaaaataat gatcggcaca ccgcagtata agccaattct 3250141 ttgatccgga atgaaaataa ggctgatcaa cacgcagcca tataaacaaa atccgagaat 3250201 cgggactagc ggataaagcg gcgttctgaa ctccagatca ttcacatttc cgccttctgc 3250261 caggaaacgc ctgcgaaaga aaaattgcga cgcacaaatg gacatccacg cgacaactgt 3250321 caccatgccc gagattgaga tacaccataa atacactgtt tctgcagcca tgacacttgt 3250381 cagcagcgaa cagcctgaaa tgcctagcgt aatcagcagg gcattcatcg gcacgccttt 3250441 ttttgtcagt ctggtgagaa aggagggacc catttgattt gatgaaagtg accacatcat 3250501 acgcgacgcc gcatacaatc ccgaattagc aacagataaa atggccgtta agatgacaaa 3250561 gttcatgata tctgccgaaa atgggatgcc gatttgatcg agtactgcta caaacgggct 3250621 ttcaatcacc cccgccgttt tgtacggaag gatggcaacc aagacgaaca tagcgagcac 3250681 aaagaaaaac agcgtgcgcc aaataacatt tcgaatggac tttggcagtg ttttttccgg 3250741 gctttcactt tcccctgccg caatgccgac aagctccgtt ccctggaacg agaagtttac 3250801 catgaccagc gtaaacataa cggccagcac cccattaggg aaaagccctc tatcagtcat 3250861 aaagttagac aaaaagggtg tctcctgtcc gcctttaaag tcaatcaagc caaacacagc 3250921 ggctccgcca atcacaataa ataatatgat cgccgccact ttgatgcttg aaaaccaaaa 3250981 ttccatttcc gcaaagcttc tgacagagag cgcattaatc aaaaagatga cgatgccgaa 3251041 cacgaggcac catatccaga tcggaacgga gggcagccac ctttgcatca aaatgcctgc 3251101 tgacgtcagc tctaacccta ctgtattggc ccagctgaac caatacagcc agccaatcat 3251161 aaagcctgtc gactgtccca gaaatttagt ggcgtaggcc tgaaacgatc cggccaccgg 3251221 catggcaaca gccaattctc ctaaacaaag catgacgaga tacattaaaa atccgccgat 3251281 gatatacgcg gcaatggcgc cgagcggtcc cgcctggcta atggtaaagc cagagcctag 3251341 aaacagccca gtgccaatca cccctcccaa agcaatcata aacaaatgcc tgcttttcat 3251401 gctgcgctgc aattcatttt tatgattctg catcatcctt ccccctttgg ttcttttgcc 3251461 gtgatggtca tccggtagct ttgcaaaaga tgaacggtgg tttgctgtat gaggagaggc 3251521 aatacatgaa atgtgtacgg tttatagact cgttctgtcc atttatggcc gtcttttccg 3251581 tacacgccca tattaatgga tggaatattc agcttgcgta tgtctttgaa cggaatggtc 3251641 ccaatcatat tccacccagg gaagttcctg ataaaagaat caatttcgcc atcggtttcg 3251701 tgcagtgata aaaaactgcc gtctgccaag taggggaaaa actttttgaa gacaaatgtt 3251761 tcgcctgtcg attcagcggt tttgtcagcc gcttctttaa tcacatgctg caaaagctga 3251821 tctcttgcgc tatcttcttt caaatagtta tgcggcaggt aaggaggtgc gtaaaataga 3251881 atgacttttg cgccttgatc ggggtcaagc ttttgaagct cttcgattgc ctgaaagcat 3251941 ctcatgcgaa gttcaaggtg ctcgttggct ttgaatgtct gctcgataca ctgctcggga 3252001 tctattcccc ggtttctcag cttttctaag tattgctcca ggctatacac ttgaatgccc 3252061 catgataaat gtttctttgg caggttggct ctttttacat attcttcgta ataatctgat 3252121 aatttttgtt ctgtctcccg gcatgcttcc tcagtgactt caataagcaa atccatcatt 3252181 tcttttgctg ttctttcata aataaaacaa ttgaaataca agctggtgct gacagccgtt 3252241 tgcacattat aggattcctt gttatcacgc tgatacaaac aggatggggg cagaaccaac 3252301 tccccttcaa ccttttctgc cagatggatg ttattgtgga gacggcttgt gatttcagat 3252361 gaaatgaaat ttgggtcaat ccctgccagt gtatcgccaa catggacttc acgcccgtaa 3252421 atgtaaaagc aaggcaacag ttttcccgcg gctccggtat agatatatct tgtctgatca 3252481 ccatcgtaaa gcggggtaat aaaatccgta ttaatagcag ccaaatagtg aagctgtttt 3252541 tcttttttta gccggttcag ctctgaaatg ctggcgagaa tgcccgaatg ctggctctcc 3252601 tcatcgggat tggccataaa caatacattt cccggcaacg tctcaaggtt ctccgaaaaa 3252661 tgcaggagat tggctaaatg cacggcgatg ccgctttgca tatcgacaga tcctcttccg 3252721 aacatccact cgcctgattt ggcatcccgc tgaacatcct gatcgaactc atagcggctg 3252781 aaatactcgg ccaatttctc acaatcaaaa gcgatatcct ttaaagggcc gaaatcttca 3252841 attccaactg tatccagatg ggcatggtaa atgactgtat ttcggctttc tccatgtcct 3252901 ttaataaacg caaaaatatt tttgcgtttg tatgggtcat tgggaatggc ctgttcccac 3252961 acatgactgg ggttttcctg aaaataagga tagctcgtga tcacttcttt gatgaaatct 3253021 gcttttgtcc cttctccaac ggtgccgttc acgctgctga ggctgaccag agatgctgtc 3253081 agcgcctcca ctctttcagc cggattcatg tgactgattt ttgtatactg cataaattgt 3253141 cctcctgatc aaaaagttga aatcgtgcga tccgctaaag aatcgcacga ttttatttct 3253201 ctcaaatcaa aaagcttcgg acgttgtttt ggcttgcata tgaagaatta agtaatcggg 3253261 accgcctgct tttgagtctg ttcctgacat attaaaaccg ccgaacggct gatagccgac 3253321 aattgctccg gtacatcctc tgttaaaata taggtttccg acatggaaat cctcgcgcgc 3253381 ccgttcaatg tgcgcacggt ttttcgtcag aagcgcacct gttaatccgt attccgtgtt 3253441 attggcaatc tccagcatat gatcgaaatc acgcgctttg caaatcgcaa caaccgggcc 3253501 gaaaatttct tcctgcatca agcgggcgtt ttcatcaaca tctgcaaaga tcgtcggctg 3253561 aataaagtag ccttttgaat catcgccttc tccgccggcc aatagcttgc cttcagattt 3253621 gccgatttca atgtatttca tcactttgtt gtaggatgct tcatgaatca cgggacccat 3253681 atacgtatca ggatcttctg gattgccgac agtcagcgtt ttggtcagcg ccacagcttt 3253741 ttccaccact tcatcataca catcctgatg aatgaccgcg cgggagcccg cagaacactt 3253801 ctgtcctgaa tatccaaatg ctgaatacac gatagaggat gcagcaaggt caagatcagc 3253861 gtccttgtcg acaagcactg tgtcttttcc gcccatttct gcaattaccc gtttgagcca 3253921 tttttggccc ggctgcactt tggcagctcg ctcataaatc cggcagccga ctgcacggga 3253981 acctgtaaat gagacaaacc gtgtcttcgg atgctcaact aagaaatcac cgatctccgc 3254041 accatctccc ggaatgtaat tcagaacgcc gtttggcaga cccgcttcct ccatgacctc 3254101 gacaaatttt gctgccacta ccggggctgc gtcagccggt tttaagagaa tcgtatttcc 3254161 tgtcacaatc gctgccaccg ctgttcccgc cataatcgcg agcgggaagt taaatggaga 3254221 aatgacgatg ccgacgccaa gcgcttcgta atgatattga ttgacctcgc cagcacggct 3254281 cttcaccgga gccccttcct tgagctttaa catttggcgc gcgtagaact ctaaaaagtc 3254341 tatcgcttca gccgtgtccg catctgcttc cttccacggt tttcctgctt ccttcacaag 3254401 atagcttgaa aattcatgct ttcttctgcg caaaatagcc gctgccttaa agagaatatt 3254461 tgcgcggtgc tccggtcttt gttttttcca ggaatcaaat gcctgcaatg cggcttgcat 3254521 cgctttttca gcaagctctt gatccgctgt agacgcgtac ccaatgatct cttctttatt 3254581 tgccgggtta atagaaatga ttttgcggtc cgtttcaatt ttttctccat ttatgacaag 3254641 cggataatgc ttgccgagct gagtgtttac aaaggccaat gactccccaa atgcagtttt 3254701 attctttgct tccgtaaaat cggtaaatgg ttcgtgcgcg tatgtgactg tcatatgtag 3254761 tccccctcgt gttatgaaat atatcttcgc atatgaataa aaatgcaaga atcatgccat 3254821 tttcttgtct tttgctgaaa aaacttgttg aatcgaacag aaatttgtct aacaggtgat 3254881 cacctttctc tttttccgat cttgaacgca aatttatttt gcgttttttg ctctttacgc 3254941 aaaaaacaaa tgcaaaatta ttttgcggag gcttctcaaa ttagacccat ccgcggaaac 3255001 gcgatgcttc tgccgatttt ctgatgcccg tcatgtaagc cgccaaacgc atatccactt 3255061 tatgtgttgc cgctgtttga taaattgttt cgaacgagct gaccatgacg cttctcagtt 3255121 tttctgcaac ctcttcttcc gaccaataat atccttggtt gttttgcacc cattcaaaat 3255181 aagaaaccgt gacgccgccg gcactcgcta ggatatccgg cacaagcagc acgcctcttt 3255241 cattcaggat cttagtggca tcaatggttg tcgggccgtt cgccgcttca acgacgattg 3255301 acgcctgaat gttatgtgcg tttttggctg tgatttgatt ggagatcgcg gcaggcacta 3255361 aaatatcgca atccttttca agcagctcct catttgtgat gacgtcagta aataaattgg 3255421 tgaccatacc aaagctgtcc cgtttatcga gcaaataagg gatatcaagg ccgtctgggt 3255481 tgtagagccc gccattggca tcagaaatcc cgatcacctt cgcgcccgca tcgtgcatga 3255541 atttggccag gaagctaccc gcgtttccaa agccctgtat gatgatgcgc gcgttttgca 3255601 gcttgatccc ttttttcttc accgcctctt caatacaaat cgtgacgccc tgtgccgtcg 3255661 ctgtttcccg tccttgcgat cctcccaaaa caagcggttt acctgtaata aagcccggag 3255721 aatcgaattc ccgcagccgg ctgtactcat ccatcatcca cgccataatc tgcgaattgg 3255781 tgtacacatc gggagctgga atatcctttg tcggaccgac gatctggctg atggcacgga 3255841 cataccccct gctcagcctt tccagttctc caaatgacat tgtccgcgga tcacaaataa 3255901 taccgccctt cccgccgccg taaggaagat tggcaatccc gcatttgagc gtcatccaaa 3255961 tggataatgc ctttacttcc tcttcattaa cttctggatg gaagcgaacg cccccctttg 3256021 tcggaccgac agcatcattg tgctgtgacc ggtagcctgt gaacactttg acgctcccat 3256081 tgtccatttt gaccggaatg cggacagtga gcattctctg cggctctttc atgagttcat 3256141 acatatctcc cggataaccc agcttccgaa gggcttcctt aatgattgtt tgggtagaca 3256201 gaaataagtt aagagcttct ttttcttcat ctttcgagac ttgctttgct gacatctttt 3256261 tcacctcatt gtttttttgg ccggctgtaa tgtaagcgct ttaaaaaatc agcccgccaa 3256321 ttcctttctt cattggattc acccttatca tcatgcaaga tccgtaccag cttttgaatc 3256381 cacaaaaaaa gagactgaaa acatctcagt ctctgactac aaatctatcg attaacgggg 3256441 atcaatcacc agctgcgttt cagcataaaa actgccgatt cccaaaccgt ttactacatc 3256501 gcctttaatc gtgtaagtgc ctgcgcgagg aagagtttta cgcaccatga caaggtcaaa 3256561 ttcggatgcg cctaacaaat caagcgtaag cgggagtctg actgtttttc catcgtttaa 3256621 aatctgtgtt tctttcagtg ttcttccatt cactgaatct cttgtcgtag catgaaaccc 3256681 gtcaggaaat tgaaattcta ccgctccaag agaaagcacc gcatttggtt tatatgtcac 3256741 ttcaatatca gaaatggtcc actctttcgt gctgttaact gtttttgcct cgattgatgc 3256801 agactgtgca tgagcttggc ccgaaggaag taagattgat agtaaaacag ctgaactgat 3256861 gaataatgaa gatacgaatg aagttctttt tagcatgaca tttcccccta attgattgtt 3256921 gaaatttggc cagagcgtcc tctgcagaaa aagcgctttt tcataattcg cgaattacca 3256981 gttctttttc ttaaaaatta atctatcatc attttccatg gaagtaaatg ttttttaagg 3257041 aatattaaca cttggaattc aatgagaatt ccttcctgtt tatacaaggt tcaaatggac 3257101 gatttccctc tctttttcta gtaacatctg cctgacattt tatatctttt atcctatttt 3257161 aaaaaagggc aaaaaaagtc gaagatgcct ctgctcttcg attgatcacg ttcctatttt 3257221 tatctgaatt cagtgttcca gttaaaaccg atcgtctcat catcccacgg aattcttttt 3257281 tcatcaggct gatccgggtt atacgacatg gtggtaaaat agataattgt cagcggcgtc 3257341 tctcccagca ctctatatcc gtgagccacc ccttttggga ttaataacag catcgggttg 3257401 tcttcgccca tataatagac gtccgtttct ccttttgtct ttgaatcctc tcgaagatcg 3257461 tataggacaa cctgagcgtg gccggttggg aagaaccaga gatcatcctg cttctcatga 3257521 taatgaaatg ccttaatcac acccggatag cttttcgacc aagaggcctg cccaaaatgc 3257581 tcaaggagat tctcatcgtc ccggaccagc tcagcaaaaa agcctctgtc atcgctatgc 3257641 ttcatcaatt ttttcacctt gactccatca atcacacgca ctgctccttt cctgcaaata 3257701 ctctcgtaac gcttcccgcc agtggcgggg gcggatgccg gcttcttcaa tagcccgatg 3257761 gctcagcaca gagtatgccg gacggggcgt tttgttcccg tattcctctg tcgttacaga 3257821 caaaatggct gtttccagcc cgctttcttc cataattgcc gtcgcaaact cataccagct 3257881 gcatatgcct gaattgctga catgatagat gcccggcgga tggctgaaca gcttgatgac 3257941 cgcttctgct aaatccttcg tataagtcgg cgaaccaatt tgatcgctga caacccgaag 3258001 ctcttgtttc gtttcagcaa gtttcagcat ggtttcaacg aaattactgc cgccatgtcc 3258061 gtacacccac gatgtcctga tgatcgtgct gtcttttgtc gttaatcgta tcagttcttc 3258121 tccgagcctt ttgcttttgc cataaatggt tttcggatcg aggggatcgt cttccctata 3258181 tggctgggtt cctttcccat tgaatacata gtccgtgctg atatgaacat attgagctcc 3258241 gatgcgggtt gactcaagcg ctgtataata agcgccgatt ccgttaatca agtacgcttt 3258301 atcaagctct ttctcgcatt gatcaaccga cgtaaacgcg gcgctattga ccacgatatc 3258361 cggctgataa tggccaaacg aatgccgtac tgagcgctgg tcagcaatgt tcatcatctt 3258421 ctttgttaac gcaatgacct catatccggc ttgcttcagc tggcggcata gttccaagcc 3258481 aagctgtcct cccgccccag tcaccaatac ctttgtcaat cagatcacct tctcatcggt 3258541 cattgtctgt ataccactga atcgtacgcg caatgccttc ttcaaacgtc acttcctgcc 3258601 gccagcccag ttcgtttttc agctttgatg cattgatcgc atagcgccgg tcatgccctt 3258661 ttcggtcttc cacgtgggcg aacaattcct cacagcccag atgcttcaaa atgacactcg 3258721 ccagctcttt attcgtgcgt tcatttccgc cgccgatgtt atacacctcg ccgtcggtcc 3258781 ctttttctaa aatcagcttg atcgcgcggc aatgatcctc cgcaaacagc cagtctcgga 3258841 tctggagtcc atcgccatac agcggaacag gcaggccctg cttcgcatga cggataatcg 3258901 tcggaatcat tttttcgctg tgctgataag gtccgtaatt gttgctgcat cgtgtaatga 3258961 tggccggaag cttgtgggtt ttcacataag acaacacgag caaatcagag cttgctttgc 3259021 tggctgagta tgggttatta ggagaaagcg gcgtcgtttc tgtaaacgcg ggatcatccg 3259081 cttttaaatc cccgtatacc tcatctgttg aaatatgaat cagcttcttg gcttttcctt 3259141 tcaagaccgc ttccgccaat cggtatgtcc ccatgacatt tgtggtgata aacggctccg 3259201 cttgggaaat gcttctgtcc acatgcgatt ctgctgcgaa gtgaatgacg ccatcgtagg 3259261 tctcgtcaaa agcgcggtcg atatcctcct gaacgctgat gtcccctttt acaaagcgaa 3259321 aacggctgtt ttgctttaat ttttccattt cctccgggtg gctggcgtac gtcagtttat 3259381 ctaaaacggt aatgcgcgca tccgtttccc tcagcatgag ctttgtaaac gtgagcccga 3259441 tgaagccggc cccgcctgta attaaatatg attttgccat cacttttcgt cctgtccttt 3259501 ccgtaaagcc tggtgtacaa gctgggaagc gagataaagc gattcgtgag ttccggcatc 3259561 tacccaccag cctgataaca catcatacgt aagctggctg ttttcgatgt atagattatt 3259621 cacatcggtg atttccagct cgccgcgctt tgatggtgat atttgttcaa tatatgaaaa 3259681 cacctctgca tcatacatat aaatgccggt aacacaaagg ttggtcggtg gctgttcggg 3259741 cttttcgatg atggaacgaa tccgcttgtt tttctcatca atctcagcaa tcccgaaacg 3259801 ttccgggtca tcaacttctt tcagaagcac ttttgctcct ttcccctgct gttcaaagcg 3259861 ttctgtataa ggctttaatg aatcttcaaa tatattatca cctaataata aaatgaaaga 3259921 ctcttttttc gtaaagcgct ttgcataaga cagcccatcc gaaatgcccg atgctgccgg 3259981 ctgtacttga taagtgatag taacgccaag ctcttccccg ttcccaagca gtttgtaaaa 3260041 ttgcggcata tgctcctttt ggctgatgag taaaatgtct tttattccgg cttcctgcag 3260101 cttcataatc gaccagtata tcatcggata cgggcctaca ggaagcaaat gcttgttgac 3260161 ggctttcgtt aagggcataa ggcgtgagcc gtttcctccg gctaaaataa cacctttcac 3260221 attaacactt ccttacatgc atttttatat ctcttgttca tataaatctt gaagaatagc 3260281 tgttacccgt ataatgcctt tgccatccac gagcggcctt cctcccttgt gcaaagaaag 3260341 gcgaagagga tagctgctca taatgcgtga catctgatag atgagtgttt catccggtac 3260401 aagctcaccc aatccaagat caagagcggc gccttggtca gcaaatgttt tggctgtagc 3260461 cgtttgatgc tcaacctgag aaagaacaag gcacggcacg ccgatgcaaa tggcttcata 3260521 tagagagatg ccgccagcga caatggctgc gtccgcttgt ttcatcaaac ctgccatatc 3260581 atttgtctgt tcgatcatct tgtactgcgg cttcttttcg atccgccttc ggactgcctc 3260641 ttgatgcggt gaagcgctcc ccatcacaaa catcatgttt ttgtctttta tgtcggggac 3260701 ttgatcagcg gcagccagca ctttaaaaat aagctgcttc ggatcacttc ctcctaatgc 3260761 aacaaggata ttgcggcagt ctttcttaag tgtgtaatcc tctcttgcgg cctgaaaggc 3260821 ggggtgaaga ataagatagt ccggaccttc atagatgcgt gtgtttccct gaacgtacac 3260881 cctgcttctg atgtcaccgt aaattccgtt aatgactgcg tcactatatt gaatcgattt 3260941 accgtttttc tcttcaaaaa gaacaatttt cgcatctgtc tccgtcttta ttttctttaa 3261001 cagctctgca ggcgcgccta gaatatcaaa caaaagcaaa tcaagcttct tgctttttat 3261061 ttcccggaga ataaattcgt gctgctgcag ctccggcttt acgatgacct gccaatgctc 3261121 ttcatgaaga aacgcttcag aatcctgatt cgtataaaac gtaatcaagc atcgctgttt 3261181 gagcccctcc gcaagcctct tcatccggac aacatggccc attccctttt catagccgcc 3261241 gtctgcgaag atcccaacat gcatggctag tcagcctctc gttcggttgc cgcatcgggg 3261301 ttccggttca gaagggtgat aagctctgag gcggatacat cggggcgctc gcctgctttt 3261361 tgatagaggg cctttatcga ttcatagtct tcctttgtat caatggtcag ccgatattga 3261421 ggggcgcgaa atcgttccgg cgcctctaaa aactgaacac gataaagagc tggatgattc 3261481 cttatatata acgtgacatg ctcctgatat tgatcctcca aagcctgaat acggctgatg 3261541 tcaattaaca ggttggcgtt gaccacttcg ccgcaaatcc ctaatggggc attcaggata 3261601 tacgtataat ccgagccttg atcaaaatgc gcctgaatca ttacatcgag cagctcagga 3261661 tcgacaaacg gattatcacc tgttaaccgg atgatgactg acggtttaac agcttctatg 3261721 accttcacaa acctatcgag gacacgttct tcgctcccgc ggaaaacacg aaagccttgt 3261781 ttgatacagt gcgcctctaa tatgtcgtca gtttctttgt cagacgtggc gatgacaaga 3261841 ttatcccgat ccttttggta aaacgcgctt tgccggacac ggtgaacgag aatatcaagt 3261901 aaacgattcg atccgagcgg ccgaagcact tttcccggaa gccttgttga acccattctt 3261961 gcttgaatga taaagagaat atcattcatg aaacgggctg tccttcagta aaatgtcatc 3262021 ccagacaatg cctgtgtcgg ctggaatgtc tcttacagcc cgaacaccgc tggtcagcag 3262081 ttcaaaaaat ctcgggtgca gcccctgcgg cttttgtccg ggccgaagca ctgcgatatt 3262141 gtcttcacta aaggcttcac ctttttgaat cggagctgtt gtaaaaatgc ctctgtatgc 3262201 aaagtttctg atttctcctt cgatggcggt cgttgttttg tatgaactgc caagcagttt 3262261 ttcagagacc ggctttgtga tcccctgttt cagctcagct tccgttttcc tgatgccatc 3262321 gaccatttct ttcaattcat ccggatttaa tgcaaacgag tggtcagcac ccggcagatt 3262381 tttatcgatc gtaaaatgct tttctatcag ttttgctccg agccgaaccg cggcacacgg 3262441 cgcttctgtc ggatgctcgc tatgatcgga gaagccgatt accgcctcag gaaaagcggc 3262501 ggcaagcatc ggaatgacgc tgaggttgct gtactccggc ggtgctgggt atttcgccac 3262561 acaatgcatt atggcaattt gattgtttcc ctctgccctg atggtgcgcc aagcttcgtg 3262621 aacatcagag atttcagctc cggctgtcga gaaaatcatc ggcctgttca gccgggcgac 3262681 atatttaagc agcgggagat ggttaatttc ataggatgcg attttaaaag cgctcggcga 3262741 ggtagactga agcagatcag ctgacccctc gtcacatacc gtacttaaaa agatcacctg 3262801 cttttcgcgg cagtaatcca atagcggtaa aatccactca gcaggcattt ccatagattg 3262861 aaccaaagaa aaaatagaga cgtccttgcc cgctgccgtc ttgtacaaac caggatcttt 3262921 ctggtacatc ctatcagctt ggaacatttg aaatttcacg gcatccgctc ccgcttccgc 3262981 cgcggcgtct atcagcgcaa aagcctgatc aagcttcccg tcatgattaa tccccgcctc 3263041 agcaataata aaaacaggag cgtctttgcc tacagtttta ttcgcgatct gaaacgctgc 3263101 cattatttcg cctccttgcc cggccaaata tgataatagt aatacgattg ttcagcggtg 3263161 aagcccattc gttcataaag gcggatcgcc cttacattgt gaagctgcgt ccccgctgtt 3263221 accgttctat gcttctgggt ctccggttgt tctatgagat tcgccaataa atgaaacgca 3263281 atacgtttcc cttcaaatcc cggctttaca gccatcaaat cgagaatgca ctcatcatct 3263341 cttgataagc cctgaagata gccgatgacc tcgccattgt gtttagcgac aatattgacc 3263401 gccgcccttc cattcagatt gtttcgtgtc cactcctgaa atatttcgtt tgctgcatcg 3263461 cggctgagat gaggatcctg aaaatatctg ctttttgtaa acgagtctcg ggccagctca 3263521 catatcgctt ctgtgtctcc gggctcaggc gggcccagtt caaaaaatgg cggtgttttg 3263581 tcataaaaag acggaggcat cgccagcttc agcaaactcc cgacaaagta agaggatggc 3263641 tgctgttgta tcacatgcgc ggctccgata tcttcagccg gaacacggac aaagataaaa 3263701 tccgtttcat ccatttggcg tacagtataa aaagcttcaa acagcctctt tagctgcccg 3263761 gtactatttg ccgcaagaag tttgacgttc atgactttct tctgaagcac cttgctttcc 3263821 cacaaagaat cttcgtaaag caatacgcct tggagcctgc tgttttcaaa aaggccgagg 3263881 gaaaattgat acggaacatc caatgtaagc tttctgcttt ggagaaattc ctcaattgcc 3263941 tctttggaga cattttcttt taccgtatac acttaatcag ccccttttac gatatcccgc 3264001 acagcttcaa tgacatcatc tacatcatcg tcagacattg atggatagag cgggagagaa 3264061 agggttcgtt tatagtaatt catggcattc ggaaagtccg cttccttata tccaaattgc 3264121 ttttgataat acggatgaat gtgtactgga ataaaatgaa cgctagtgcc gatattgtat 3264181 tcatccttta aagccgtaat catttcgctg cgcgtaaccc cggccttttt ttcatcaact 3264241 tgcagaacat atagatgcca ggcgtgcctg ccgtcatcat ggacaaacgg cgtgatcagc 3264301 ccaggaatct gctgaaaagc ggtttgatag cggccggcaa tctcttctct ccgtttctgc 3264361 atatcatcca gccgtttcag ctgatgaagt ccgagggccg cctgcaaatc aaacatattc 3264421 atcttatagc cgggcgattc gacttcatag taccagctgc catttgaaga ataacggttc 3264481 catgcggctt tactcatgcc gtgaaggctt agcacccgta tcttatcggc aagctcctca 3264541 tcatcagtcg tcagcatgcc gccttcccct gtcgcgaggt ttttggtggc gtaaaagctg 3264601 aatgccgttg catccccgat agaaccgatc attctttgct tataagtcgt atataccgca 3264661 tgtgccgcat cctccagcac gaataaacca tgattttggg caacagccaa tattgcatcc 3264721 atatcgcagg actgcccgcc aaagtggacg ggcacaactg ctttcgttcg cggtgtgacg 3264781 gccgcctcaa gctttaccgg gtcaatattg agcgtgtttt cgtcaatatc cgcaaacaca 3264841 ggcgtcgctc ccgtatgaat aatcgtattg gcggtcgagc tgaacgtaag cggagaggta 3264901 atgacctcgt ccccgggccc aatccctttt gctttcaaag ccaaaaataa agctgcggta 3264961 catgaattca ccgccacggc gtgcttcgcc ccgacaaacg cggcaaactc tttttcaaac 3265021 tgctgaacct tcgggccttt agagagccat cccgattcaa gcgtttctgt aacctcctga 3265081 atttcttcct taccgattaa cggcaatgag taagggagaa aatgatttct cttttgcacc 3265141 atttctttgc gctcctatca ttttattcag tatcttcccg cctgtaatca acccctgttt 3265201 tggctttcag ttccgcaaat aaagcatttg ttgattctgc caccggataa ttagccgcta 3265261 tgaatgccag gcgcgcctct tctgcttttt gatgcacgtc gggacttcga agaacctcaa 3265321 ccaaggtgtg cgccagttca tccggctggt caaacataaa atcgccaaga gactcataat 3265381 acggatacga gcgatttccg gacgattttc ctatcagcac aggcttttga aacagcatgg 3265441 cttcaagacc gactgtcgag gtttgcgtca ctgcggcatc aacatacggc agcaaatcat 3265501 aaagctccag ctcctttttg atgactctgc atgcttgatg ttttttcgcc gcctcgtgat 3265561 acagatcaag cttgtttttt ccgatttccc acgggtgggg tttgataatg atttgcagct 3265621 gcttctgatc agaaagcccc tgcagcacac cggaataaaa gtcttctgaa aagggctgag 3265681 tggcaatgag cacaattttt ttagtcggct gaaaagcaag ttttcgatag aatatggaca 3265741 tatccatagg cgttctgtta aaaatctgat cgaagcgggg atgtcccgtt acgagaatct 3265801 gctcgggttt acagcctttt cgtatgaacc actctgcttc atacgcacca aaaacagctt 3265861 gataggttgt aaaaacagga atgaaggctt catctcccat caatgcgcca tgctgaagac 3265921 aaatgctgac ggcccctttt ctttgacaca tgagagcgag caccctgctg taaatgtctt 3265981 ctgccgttcc gacaataaca gctgaaatct tttcctgttc aaacagcgca tcaactgtat 3266041 caatggcctc tataaataaa ggaatatctt tgaaaagccg gtcgcgaaac gcttgatcac 3266101 caaatgccgg gtgatcatca taaggggcga gaagcgaaca ggctgtttcg agatactgct 3266161 tcgaatcgcc tttttggcat gaatccgcaa tctcccgctt gctaattaca ggcagatcac 3266221 aataatgcgg caaactccat ctggccaaaa cagccgtttt ttcaggatca aattgatagt 3266281 aattttcgtt tgaaaaacgc aggtaatcaa agtgcaaaat gactttccct ttaacaggtt 3266341 cgtcatttgt tttaacgatg ttttggattc tttcttcaaa aaacggctga atctgtccct 3266401 catcgatatg ctgatccacc gatccgaata attccggttc ttcttccatc atcaccctca 3266461 gttcagggct gatgtattga taaaaattac tgataagccc aagcggaatc cctttgtagc 3266521 gaagtttgtc aaaaagctcc acgtacttcc ggtacagcac ccaataattg cttaaatagg 3266581 ccgacaagct ctcaccccat tccaagcttt tttaatgatt cacgcagctc tcggcaattt 3266641 cgctgcggag gaaggttcct gacaaattca tttttttcta attcaaacag ctgaaagtga 3266701 atcgattggt cggtaatata attcaggtcc agctcctcat ccagtgggta aaacggataa 3266761 aaatgattga ctctccaaaa gaaccgggca tctcctatac ggtaaaacgc cgggctttca 3266821 tcccaatagg agccaaactt ctcctttacc ttctcaagca ccgaatacct gtgcatcacc 3266881 gagcaatgat caattgcgca cggcgcgttc catgtcactt gagcggcagg cctgacagtt 3266941 tcttttacaa tgtcacgatt ctcgtttaaa tgataggttt tggaggctga gtaaatcaca 3267001 gccttttcag gatgggtatc gagctcccgc accattttca ggaggcggtc cggcatatag 3267061 atgttgtcat ccgtcgcata ggtgatatat tcaccctccg ccatctcaat cgcctgattg 3267121 atcagtgccg cgtatctcgt tttttctgtt ctttccttca ctccagatat atcgctttga 3267181 taaaaacgca ctcggttatc attcaaaaaa ggacggatta cattcagcgt ctcttcattg 3267241 gagttgtcat ccataataaa caattcaaaa tctgaaaacg tttgtgagag tatgctagaa 3267301 atggactttg ccacataatc gcttttgtta tagctcgtca taatgactga tactttaggc 3267361 aaatcctaca cctccttctt ggaacttcac acctgaaact atcgttatct tatgttgctt 3267421 atgctcaagt tgcgctaggg atacaaacca atatgcgaaa agtttgtgta tgtttctgaa 3267481 aaacagcggc tgcccagagc gaaatctgat cggtccgctg ttctttttca gcataatcca 3267541 agcatcagcc tcataaggtg aaagagataa aaatcgcacc agcgactaag atcgttttcc 3267601 atcggaggtg agtcatcgcg gagcgttcac ctatacatcc agaacatgtt ttgaatggtt 3267661 ttcataaaaa ggaggaacga tatgaaaccg aaaaaaaatc aatatcagca aatgcaggca 3267721 tttgataata tgcaggggta tcagcctcag tttggcgcca acccgtaccc gcagcaaggc 3267781 caaggctcac aaatgcagac aatggggatg cagccaatga tgccaatgca gcagggacag 3267841 caaggacaac aaggacagca gggatttgga ttcccgggcc agcagcaggg cggcggtttt 3267901 caaattccat cggggcctac accgtcagga ccgggccaaa gcgttcccgg catgctgcct 3267961 gttgaggaat cttacatcga gaatattttg cgcctgaatc ggggaaaaac ggccaccatt 3268021 tatatgacat ttgaaaacag caaggaatgg ggctcgaaga tttttcgcgg cgtcatcgaa 3268081 gctgcgggcc gggatcacat tattatcagc gacccgaaat caggaacacg ctacctgctc 3268141 ctgacaatct acctcgatta cattacattt gatgaagaaa ttgcttatac gtatccatat 3268201 tccatggcgt cctattcgcc aagataagaa aaaagccaat cactcatatg atgaggattg 3268261 gcttttttgt ttatagatat ttgacggctg cgacaacgat cataatccaa gaaataataa 3268321 acgccacacc gccgagcggg gtgatcgctc caagaatgga gatttgcgtc acacttagaa 3268381 tatataagct tccggaaaac agcacaattc ccgcaaacat cagccagccg gctgtcgtga 3268441 cactgcctat gccggataat ttatcagcca gaaacgcgac aacgaataac ccaagggcgt 3268501 gatacatatg atactgcacg cctgtgtgcc aaacctgaag atacttatca ggtattttcc 3268561 cttctaatcc gtgagcgccg aatgctccga gtcccacggc aagcagggcg ttaatggccc 3268621 ctaatatgat aaaaactttc atctatctct cccgcctttt cgttaaactc atatcattta 3268681 tcttatcgca cctgcaccaa aattcaatgt ttgttctccg ttgacacgag attgtcggat 3268741 tttctcctgc gccaaagctg gaactggtca gctgctattg cagcaagcgt ccctaatacg 3268801 agcccgttgc ttaatagaga aataaatacc ggatgcaatc cctttaacgc agtttcagga 3268861 acaaacatga taccgacccc tgtcagcagt gagataccga tgatagacct cacccttttt 3268921 gattcttctt tctcatatga atcaaattcg gcaaaggcca gaccgcccat tgcggagaac 3268981 acaacaaaat tcaccgcaaa tccaacgggt gacggcaggc tcgcaaacgt attcataaaa 3269041 aacgggatca cgctgatcac gataaccaga atactgccga gcataaacgg ttttttagaa 3269101 ggcatcttgg tcgtttcaat aaaacctgcg gctcccgaaa tcggaacagg cgcaatagct 3269161 cccgtcaaac cgctaagcag atggctgaat gaagctgcaa aaccggcatg gcgttcatga 3269221 tgctttccat caggctgttt gctgaatttt ttcatggcga tgtccacgac cttcatgctc 3269281 gccagcatat tcacgatcag caagatggta ataaaaatag aagtgatgat caggccgctg 3269341 ttaaataacg gggtcccaaa aggaaacagg gaaggcagct gaaacagccg gtccggcatt 3269401 tcaatcggct ttgcggctcc ggcagccgca aacagcaccc acccgccgaa caaggctaat 3269461 aaaatagaat attgcttaaa aaacatgatg ttcgaatttg tcattataaa agcggcagcg 3269521 atcacaacaa gcgccaggcc aaatacaaga ccgtccaccc cgtcctgtcg ataaccgatt 3269581 ccgagaattc cttttataat gggctgactc agctgcatga caagaagcaa taaatagacg 3269641 cccgttacaa ccggagtaaa caattttgca agtctgtcaa tgaccttgaa aacacttaac 3269701 aaaaagaaac atacagcgct tacaagaaga gctccctgca aaccccgcag tgtgtctcca 3269761 tatgtcgcaa acacagttcc cgtcagccct gcgtaaatcg tatacactcc ccaccacaag 3269821 ccggctgggc tttcattgat cggcagtctg tggcctttca aacactgaat gacggcggca 3269881 attcccagta caaaaaaagt gctttgaatc aatcttgcag aatctgagtg atccagatga 3269941 aacgactggg caaccgccac cggaacaaca atcgccgcag caataataaa cgctgtccat 3270001 tgcagcgcgc caagaaccaa tttcacgtaa gctcaacctc tctctttaaa aatcaaataa 3270061 agactctccg tttccatcct cttcctgctt ctctttttct tgctttcgat atttgtttaa 3270121 tcccgcgctc cccatcattt tttccatcat cagctggtct gtcgatggcg gcgcggcggg 3270181 acttggcgta acgctcggct gtatgcgggg cgcgctcgcg ttctccggct gatcaagcac 3270241 gacatcacac agagaacgga caaccgctac ataacgcttc agctcctcat cccgttcagc 3270301 cgtttttgct ttttttagct cttcttccat cttttgaatc aaagcagata tatgaatgtt 3270361 catgaagcac cctccaaaaa aataaatgtt gtcttcctgc attttatcaa attcctgctg 3270421 aaaacgcaga tatgagtttg ttattttttc tgacaaacct tgcgcgattg acaagcagaa 3270481 gagatttttc acataataaa tcaccatacc ttacaaaaag gagaaacgga atgaacagca 3270541 tcccctctat catcagcaag cataaagcct attttgcggc gggacatacg agaccgcttg 3270601 aatcgagact gaacattttg cgaaagctga aacaagccgt cagaactcat gaagccgatc 3270661 tcatagccgc tctctaccag gatctccata aatccgagca agaagcatac tcaacagaaa 3270721 tcggaatcgt cttggaggaa atcagctttg tcatgaaacg gctgagaaaa tggtccaagc 3270781 cgaaacgagt caaaacgccg ttgactcatc taggctccaa aagcatcatc atccctgagc 3270841 cgtatggaac cgttttggtg attgcgcctt ggaactatcc cttgcagctg gcgctttctc 3270901 cgttgattgg cgccattgcg gcggggaaca cggtcgttct caagccatca gaatatacgc 3270961 cggctgtttc tgctattctt tccaaactca tcagcagcgt ttttccaact gattatgtcg 3271021 ctatggcaga aggcgggccc gatgtcagca cagcattatt acagcagccc tttgactaca 3271081 ttttctttac cggcagtgta gctgtaggaa aaatcgtcat ggaggccgcc gccaaacaat 3271141 taattcccgt aaccttggag ctcggcggca aaagtccctg catcgtccat aaagatgctg 3271201 acattcagct tgccgccaaa cgcatcgtct tcgggaaatt tacaaatgcg ggacaaacct 3271261 gcatcgcacc ggattattta tttgtccacg aggacatcaa aacgaagctc acagaagaaa 3271321 tgaagcgtgc gatcagagaa ttttacggcc ctcagccgga acggaatcca cagtacggca 3271381 aaatcgtcag tgagcgccac tatcagcggc tgctcagctt tctgaatgat ggcatcccgc 3271441 tcacaggcgg acaatctgat cccaatcatc acaaaattgc gccgaccatt ctcgaacaag 3271501 tgagagatga ctctccagtg atgcaggagg agattttcgg gccgattctt ccgctcttta 3271561 cataccgcaa tatcggggaa gtcattgaga aagtccaatc gcgccctaag ccgctcgccc 3271621 tgtatctctt caccacaaac aaagaaattg agcgcgctgt tttaggaaat ctgtcgtttg 3271681 gcgggggctg tgtcaatgat acgttaatgc atgttgcgac gccgtatttg ccattcggcg 3271741 gcgtcgggga aagcggcatc ggcagctatc acgggtttga cagttttaac acattcacgc 3271801 acaaaaaaag cgtcgtcaaa caaacgaacc gtttcgactt cgcatttcgt tatccttcct 3271861 ccaaaaacgg gctgcgaatg attcgaaaaa tactcaaata aaaaagcgca gatcacctgc 3271921 gctttttaca aatccttaat acaccaatca atcggcgcct ctcccatttt ctccaaatag 3271981 gcattcgccc gggaaaacgg tctgctcccg aaaaatccgt ttctcgcaga aaacgggctg 3272041 ggatgcgtcg attcaatgat aaaatgcttg gaggtgtcga tccgttcttt tttcatttga 3272101 gcatgccgtc cccacaaaat aaagataacc ggccgctctc tttcactcag cacgtcaata 3272161 attcggtccg tcagtcgctc ccagcctttt cccttatggg aattcgcctg tccgcgcctt 3272221 actgtcagca cagtattcag caaaagaacg ccttgctttg cccagctcac aagcgacccg 3272281 tgattcggga tgctgcaccc gatgtcctgc tgcagctcaa gaaagatatt ttttaacgaa 3272341 ggcggctgct ttacaccggg cttgacagag aagcttaaac cttgagcctg tcccggcccg 3272401 tgatacggat cttgacccaa aatgacgacc ttgacatcat catatgatgt ataatgcagc 3272461 gcgttgaaaa tatcccggct gtccggataa atcgtttgct ccgcgtattc cctcttcagc 3272521 atctctctga gctcttgata atacggtttc tcaaactctt cctttagctg attccaccag 3272581 ctgtcttgta aaagctgttt caagattcag gcctccttac gaacgatgaa gtctggaata 3272641 gacaggctcg ccatcccaaa ccatttcact ttttgcttcc cgcctcttca tctcaggctc 3272701 ttcaagcagg acggcaaagt ttttcgtcgg cagctccccg agtccgtgct tttcacttaa 3272761 acgatccaaa tattgcttcc gcttggcgcc aaggtcagca gactgattgt ctcccgcgtc 3272821 actgaaggca taaatcacgc tggcgcaagg gacacgcttc acccggtaat ccttggccgc 3272881 gcgcaaataa aaatcccagt cccagtaatt gtgcacatca gcatcgaaat acccgatttc 3272941 atcatgcaga aaacgtctgt acatgctgcc cgacggcacg tatgtagaaa acactctcat 3273001 atcctcatag tcagcggtat aagcaaacaa tttccgtgac actggatacc ttgttccgtt 3273061 tttctcttca aacgaaacta tttccgcatc agaatgaacg aagtctgccg tttctatttc 3273121 ctttgccatt ttctcgatat gccctggcgt aaagaaatca tcgtcatcac acagcataat 3273181 gcaatcccca gacgcctctt ttacaccggc atttctcgca gccacatgcc ccgagttctt 3273241 ttctaaattg atgacagcaa tcggcagctc cggataaagt gctttgaccg gcacgaccga 3273301 ttccccggca tcattcacaa taataatttc atacggcatc aaggtctggc gggaaatcga 3273361 ctccaaaagc tcacacaaag ccggaatccg attataggtc acaattacga tagaaatctt 3273421 catgatgctc tccttctcat tttcatagtc atgtactatt aaaacatata ttggacggga 3273481 gatcagtggg aatatcctac tgaaacggca tactacaatg atagaaacag caaagtggct 3273541 ccgatcagaa gcaccatgat cagcatcaga tctccaaaga catgaaagat atctttcatg 3273601 cggacgccat tcggaaggat aagacgccac agcttagatt gatagaccgg cagcagcacc 3273661 agtgcataag aaagacacaa aaatgtaaaa gccggcggca caaaagcaca gcctgcatcg 3273721 tcccaattca tcatgatgtc tttcatacta gatccatcca ataaaaacaa agatatcatg 3273781 agggctagca acacaaagga ccccaattga acctcaaaca ggcgcatttt ctggttatat 3273841 gcaaatcgga ccgcccaaaa ccagacataa gcatatgaac atagcagcgt aagaatggca 3273901 cctgctgtaa agacgacatc aggcagccga tcaagcagaa aaacaaaagg caagctggct 3273961 gccatagcca agagcatgca gccaccagta aacaaaaata ctgccccatg agctacaaaa 3274021 ccatataaac aagagctaat cctcacgaca tacacctcct ttacatagaa attctatgta 3274081 tatacctaaa aaatcagaca agctgacgcc tgccaatata acagcccatt cggccaaata 3274141 acggaaataa cagcgttgca aaagcacaag ttccaacaaa ccaaggtgtc aacaaggatt 3274201 gaaacagcgc agcaggaatt acattgaata gaaaaacaag cataaaaatg acgtttggca 3274261 ccattgagat cagaatcgta tgtagaacaa gcttttctcc gcgttttcca aactccttca 3274321 cgccttgata cccaatcagc acccagtaga tcatatatgc agctaagatc agccaaacag 3274381 aaacagaaat gcctttccat actgcttgaa caaacggtga ttcaagccat acatgcatta 3274441 ttgtaatcgc aatgccgaca gcgaataggg cactgttaca gaaaagatgg aacatcaaaa 3274501 acgcacgaaa cgttactggc tgtattttct taaacgaaga aacaatgtca gttggtgttc 3274561 caaacgcctg caataaagtc tgcatagctt cctcctcact ctttccttcc tgaaaagagc 3274621 gaaacagatg atgttcaata tggctctcaa tctcttctat catcgcctca ccctcaggaa 3274681 gccctttaag cccgcttttg atttcggata catatgtttc tttatccatt ttgtccgctc 3274741 cacttcagta ttcggtccat catggctgaa aatacgctcc attccttcgt gcgttccgcc 3274801 agcacttctt tgccctcgtc tgtaatccgg taatatttgc ggtccggtcc tttctcctgc 3274861 ttctcccagt aggaagaaat atacccttgg cgttcaagct tgtgaagaga aggatacaag 3274921 gtcccttctt tcatctgcag ttcatttccg ctgcggcttc ccatttcttt tacaagctca 3274981 tagccgtaca tcggccgctc gttcagaagc gtcaatacca atataaccgt gcttccctta 3275041 accagctcac gatttaacat ctcaaaaccc ctacctagtt ttcttatgta gcattttacg 3275101 aaagcccgtt gagattgtca aatgattcct atagatcttc tatattgtga tacagagaaa 3275161 atctaactat aatgaaagac aaaacatgat ggaggttcaa gacatgtcta tgcataaagc 3275221 actcaccatt gccggctcag attccagcgg cggtgctggg attcaagctg atttaaaaac 3275281 atttcaagaa aaaaacgtat acgggatgac cgccttaacg gtgatcgttg cgatggaccc 3275341 aaacaacagc tggaaccatc aggtattccc gatcgatact gatacaatcc gcgcccagct 3275401 tgcaacaatt acggacggca tcggcgtgga cgccatgaaa acaggaatgc tgccaaccgt 3275461 tgacattatc gagcttgcgg caaaaacgat caaagaaaaa caattaaaaa atgtggtaat 3275521 tgacccggtt atggtttgca aaggtgctaa tgaagtcctt tatccggagc acgcccaagc 3275581 cctgcgtgag caattggctc cgctagccac tgtcattacg ccaaacttgt ttgaagccag 3275641 ccagctcagc ggcatggatg aactaaaaac agttgacgat atgatcgaag ccgcgaaaaa 3275701 aattcacgca ctcggcgctc aatatgtcgt cattacaggc ggaggcaaac tcaaacacga 3275761 gaaagccgtt gatgttctct atgacggaga aacagcggaa gtccttgaaa gcgaaatgat 3275821 cgatacgcct tatacacatg gcgcaggctg tacattctca gcagccgtga cagcggagct 3275881 tgccaaaggt gcggaagtca aagaagccat ttacgcagcg aaagaattca tcacagcggc 3275941 cattaaagaa tccttcccgc taaaccagta tgttggtcct acgaagcatt ctgcactgcg 3276001 cctgaatcaa caatcataaa aaaaggggct gccttacaga gaggcagccc tttttaaatc 3276061 accgaagact tttcacagaa aaaactgccg atcccatcgg cagcctgttt atttgatttt 3276121 taaattgttt gcagatttcc tcaaaaatgt ttctatcgac tgaacaaaaa gtgcatattc 3276181 cttcatttgt tcatatgccc gcgtgagaat ttccgccgtt tcactgtgcg gcgttgttcc 3276241 gccaagcatt tttttcagct gaagcagcac atccttatat tcttctcgct tatcttcaac 3276301 ttggttagca gccttttcca aacattccgg tgttatcttc tgttcatgta tattcaagaa 3276361 aacaactcct tttacagaaa aaaatagtag gttatcgttg aagaatagca cagatggctc 3276421 agatttcaca taagaaaata gaaggatttt ctacataagt gtccaaattc cgacattcat 3276481 ttcagatttc ccggtcgcac tggctgttac ttcatgattt cccgggaaag gaaaatatct 3276541 tgcactcaag acctcttctc cgttattgat aaagatttcc acagatgacg cgtcgagaaa 3276601 catgtgtacg gtatgcaaat ccttgatgcg gcaatgtctc gcttctgttc tttttccgtc 3276661 aaagctcttt cgttccagcg taacaatccc ctcgtcttta tggaaggaaa acgtagccgt 3276721 tccgcggata ctgattgaaa agccagactc cgtatgaatg tcttccagta gaatctcagt 3276781 tctttcaggt ttttccactg gaagcgcacc agatgatcca tgcatgttga tgtgtatttt 3276841 tttctcattt ctgcgcatgg cttttagctc aggcagcggc tgctgaatca gcttctgtcc 3276901 tgaaagcgtc agctgtctcg gcagcgtcat gcagtgaatc cagtggcagt caatggtcgg 3276961 atgggaccct tcatcctgat caggcaccgc catccatgca aataaaatcc gccttccctg 3277021 atcgtcttca agtgtttgcg gcgcgtaaaa atcaaaacct tgatcaagct ccgtaaattc 3277081 accatgcttc agttcaggct tgttataatc gaggcggccg acaaaataac ctgattgata 3277141 tacgttctga taacggaaac cgtcagcctc aagcccttga ggcgaaacaa tcagcacatc 3277201 cgatccttga agggaaaaca aatcagggca ttcccacatg tatccaaaat cgtccagccc 3277261 gttgaagccc gcgccggtta tcgggccaag aaatctccac tctgtcaggt tatcagaagc 3277321 aaacaacaca gcctgccctt tcaaattctc tgtttgcgca ccaatcacca tataccatgt 3277381 gccttcatgc tcccatacct tcggatcgcg aaaatgcgcc gtatatcctt ccggaaggcg 3277441 ggcgacgaca ccctttttct caaaggacag cccgtcgtca gaaacagcaa ggcattgata 3277501 cgtttcccga tttccatcct gatccctgac atttcctgtg taaaaaagat agagccgatc 3277561 gtctttcgtg acagcgctgc ccgagtagca gccgttttta tcaaaccaat cactcggagc 3277621 cagcgcaatc tcttcccgct tccaattcac aacatcctgt gtcgtataat gcccccaaaa 3277681 ttttgcgccg tgccccgtct gaaacggctg ccactgaaag aatacatgat agctgccctt 3277741 ccaataaatc acgccattcg ggtcattcag cagcccaacc ggcggcatga tatgaaaatg 3277801 ctggcggtgc ggatcgctgt tagcgatggg ctcttttttc tccacttctt cataagcccg 3277861 gcgacgaagc tcctggtcat gtgctgtcat tttttcctct cctcatcctc attaatcttc 3277921 atgacaaatg ctgcaatgaa cgctgacact gccgcaatcg ccatgccaat cagatagtga 3277981 atcaagttgc tgaagccaaa cggagccgca atggcgatca tcggaattcc cgttaacccg 3278041 taagcgtttg cagctacatg tgtaaagacg acatatgccc cacccaatgc gcctccgatc 3278101 atcgcggcga taaacggttt tcggtagcgc agattgactc cgaatatgac gggctcagta 3278161 atgccgagaa aagcggaaaa tgctgccgga agcgcgattt cttttgtctt tgcctttttc 3278221 gccataaaga agacggcaag acctgccccg ccctgtgcga cattcgccat tgaccagatc 3278281 ggcagcaagt agtttttgcc tatatctgca attagccctg cctcaatcgc atggaagctg 3278341 tgatgaacgc ctgtcagcac gatgagtgaa tacgtgcccc cgaaaatcag acctgcgaca 3278401 aaaccggcat ggtcatatac ataagttaaa gcaaccgtaa tgccggagcc aagcgctctg 3278461 cctagagggc caatcgcgat aaaagcaaca aacccggtga caatcacagt aacaaatggt 3278521 gtaacaagca aatccaccgc atgtggaacc acttttctcg tccatttctc taccttgctc 3278581 atcacataca ccgcaagcag gacagggata acagttccct ggtagccgag aagagcgata 3278641 tcaaatccga aaagatgcat gtaatcaggt gtcgcttccg ccaatcccca tggatttaaa 3278701 agattcggat gaatcatgat tcccccgatg accgctccca agtatggatt gctgccaaac 3278761 tcttttgaag cgctgacccc gattagaatc ggcaagaaaa tgaatgctgc acttgaaaac 3278821 atatcaagca gctgcaaaag cgcagaatcc ttgctcatcc aatgaaacgc attgatcata 3278881 cccagcaatc ccattaatag gccgctggct acaatagctg ggatgattgg aacaaaaata 3278941 ttagaaagcg ttttcgcaaa tctcgcagcg ggattcagct tttcttttgc cgcatcctga 3279001 tgattgacgt gttcttcacg ctcgatatca gcttctttag aaaaggcatc gaatacttta 3279061 ttcacaaggc ctgttccgaa aatgatctgg tactggccag agctgctgaa agccccttta 3279121 acgccatcaa gctcttctac ttgtgcttga tctatctttg attcatcttt catcactaaa 3279181 cgcagtcttg ttgcacaatg agccgcgctg ataatatttt ctttccctcc gagaagctca 3279241 atgaggcgtt ttgcagtctc tttgtaatcc atctatttct ccccctttta tttaaacaaa 3279301 aaagacctaa aattcgccaa cgaataaagg acacagcgat cctttttcat ttacgcaaat 3279361 tttaggtctt gcctgcttta ccagtcacaa tcccgcttat tcagattaag aatacgcttt 3279421 catcataaat catgatagcg ttttcgtcaa ctattttttt agttaaatag tttgatataa 3279481 catgtagaca aaaattcgta aaaattaatt gtgaaatact tcacaatatc gtgctatact 3279541 atgctcaatc atgaaagaaa gcaggaaaag acaatggaaa ctcaagcatt acaaaaggtt 3279601 gaacagtatg ctttgaaaaa acaaaacata ttcgcttcaa gcaaaatccg ttatgtgctt 3279661 cggtccattt tggccagtat atttattggt tttggcatta cagccgcaag caaaacaggc 3279721 agctatttct ttatggctga ttctccgttt gcctttccgg cagccgctgt cactttcggg 3279781 gccgctattc tgatgattgc ttacggaggc ggagatttat ttaccggcaa caccttttat 3279841 ttcacctata ccgcgctccg gaaaaaaatc agctggcgcg acaccctata cttgtggatg 3279901 tcaagctatg ccggcaattt aatcggcgcc attctgtttg ccatcctgat cagcgcgacg 3279961 ggactttttg aggagccttc tgttcattcc tttttgattc atttggcaga gcacaaaatg 3280021 gagccgccgg cttccgaatt gtttttcaga ggaatgctgt gcaattggct tgtgtgcctc 3280081 gcctttttca ttccaatgtc tctcaaaggg gaaggagcaa agctttttac catgatgctt 3280141 ttcgttttct gcttctttat ttccggcttt gaacacagca ttgccaatat gtgcacattc 3280201 gccatctcgc ttttgatcga gcaccctgat acagtgacac tgatgggagc agtcagaaac 3280261 ttaatccccg ttacgctcgg caatctgacc gcgggaatag ttatgatggg ctggatgtac 3280321 tacacactga atcctgatca ataaaaaaac ttccagagat cactccctgc aagtcaaagc 3280381 ggttattccg agagatcttg aagacgctgg acatgcagcg tgatatagcc ggcctcggat 3280441 tccggcaaat gtaattgata ttcatttttc aaaaactccg ccagctccag cgcacattga 3280501 taggcgaatg aatacttttt ttggatgaaa taaagcatct cctcgtccat acgatggagc 3280561 gcttcatttg attccaaccg gctgaccgcg tatcgcaaat gcgtgacaag gcgttgatag 3280621 gaaatgctgt tttcatccac ctttcgatta aagtattgtt ttattttctc tatcatttct 3280681 ttgatcatgg tcgtatgctt cagcgctgaa tacatgctct ccgcatccat cttcgccgta 3280741 tggatgtgaa gggcaatata acccgcttca tcttcaggca gagacacgcc caatgtctct 3280801 tttacatgtc cgatcgccca caggccgatc tcatattctt ttttatagag cgcctttatc 3280861 tcatgcagca atttattctg cacaagcagc ccattttgaa tcctttcgat cgcaaaggac 3280921 aaatggtcgg aaagcgcgat atgaatgtga tcgctcagcg gcgccgcgag ctctccttcc 3280981 gcatagctga tgatatcctc agctatttct atatgctcct ccggcagtgt ttgcaggatt 3281041 tgtttgaact tttcattctc gtcgcgcacg acaaagatct tttccacttt attcataggg 3281101 atgagatcat ttttcttttt ttgaaaagcg attcccggtc ccatcacgat tttttcctga 3281161 tcatcctctt ttattaaagc cgcattgttg tttaatactt tatagatttt caagaggtta 3281221 tctctcccgc caatttgctt ttgactggga ttttacctcc ttttgaccgc catgtaaaga 3281281 tgcgggcccg ctctctcctg ctttggcgat tccttgaagg cttgcaaaca tcttctttta 3281341 taaagcgcgg cggctttcgc tttctgcttt tcttcctcat tcacagccat ccgccattca 3281401 taaaacgaaa cgagtcctgc ggcctgcaca gccgcctttc tttggtatgt acgctgagcc 3281461 gaatagaccg cggcagccgc agtttttctg tccggcgtca cccagttcat caaaaagacc 3281521 atccacaccc gtaaagatac aagcaaacgt ttcatagaaa aacatccctc cgcttctttt 3281581 tggcaggcag cctttttagc agcccgtttt ctcagccgca gcccgcaaga aaagacggcc 3281641 gatttctttt ctcgcaaact agcggctcta gcaaaactca tgactctatg atagaccgtg 3281701 gaaagagaat tctttgtcac aatatgagtg aaaaaaccaa ctagttttta gaagttttgt 3281761 tgaaagctga aagaattgaa atgaaaattg gagaaccgct ttgaaaactt tatacacaag 3281821 ttatcccaaa gataagaaca acttaatcac aagagatatc cacatgtcca caaactctat 3281881 ctatattttg tatacgaacg tatattccta actatatata tacacaggtt tattcactta 3281941 tacacagggt tctgtgtata actccttcgt tatacacaaa caaaatccaa taaatggtcc 3282001 aaatgacaca aggatttttt tgaattttca agaaatatat actagatctt tcacattttt 3282061 tctaaataca aagggggaaa cacattgaaa aaggggatca gtcagcaaac gcctcctgca 3282121 ataagcgata cgatcggagc ttatcttcaa aatgatgcgt gatggtcacc accatgattt 3282181 cctctgtttc atacgcgtta ctcaaagcta acagccgctc cttaacctgt tctttcgtac 3282241 caacaatcat tcgatttcga ttatcagcaa ttcgtctctg ttcataagga gaatacgtat 3282301 ttttccgaac agcttcatac gaaggaactc cctctaaagg aataccctgc tctcccgcca 3282361 aaagtgtaaa atcaagcaca gccccaagct cctctgcctt ctcctccgtg tcagcacaaa 3282421 gaacaaaaac agcaactgcc gctcgaggcg tatctcctaa cacagacggt ttgaatcgcc 3282481 tcttatactg tctgacagta ccctctccgc cctctccatt gataaaatgg gcaaacatat 3282541 agccagcgcc agattcagct gcgagcagcg cgctttctcc agatgagccg agcagccaca 3282601 catccggagc cgttgaaata tgcggcgcag cggtcagatt cggaaaacgg tgtttgtcat 3282661 ccgccaaatc atgcaaatac atggtcagct ccttaatttg ctgcggatac tgatcagcat 3282721 tgcgcttacc accgtcattc agcgcccatg atgcaatcgg cattcccccc ggtgctctgc 3282781 caagccccag gtcaattctt cctggtgtca gcccctccag aacacgaaag ttttcagcta 3282841 ctttataagc actgtaatgc ggcagcatga ctcctcctga tccaacacga attcgctttg 3282901 ttttcgctgc tatatgactg attagcacct caggactgga ccctgccagc cgttttgaaa 3282961 agtgatgctc agaaacccaa aatctcttat atccaaggtc ctcagcagct tgggcaagcg 3283021 caacggtttg ctgtaaggcc gtttctgcat tgctgccctc tgatactgga gattgatcta 3283081 atatacttaa tgaaaccatc cctaccacct catcctcatc gtatcactga tcccctattt 3283141 tttctccaaa gccgctcaca ctgcttatca gtgtccccta tcattcgcca tttatttgtg 3283201 aaagcatgtc cctatttgtc ggaatatgtt acacgtgaaa cataaaaacc cctccagacg 3283261 gagaggtttg ctttagtttt tattaaagcc cttttctttc acgtagtcat ttaaatacgt 3283321 acgcggcttt tgcttcataa agttcagtat ttgatcggac cacgtttctt cccgcttccc 3283381 gtttgttctt tctctatagt aatcagaaat ggttttgtca tacgtattca tagtatgacg 3283441 gaaatcgtct gtgttcacat tatacgtatt ttcatgataa acggcctgct ttggcaatct 3283501 cggttttttg ccggaaaggt tcgcaggatg gcctactgcc agtccgaaaa gcgggagcac 3283561 atggtcaggc gtttgcagca cctctgtcac cttgtccaat tcattccgaa tgccgccgat 3283621 atagcaaatg ccaagcccca tggattcagc ggcaatgctc atattttgcg ctgccagcgc 3283681 cgcatcaatc aagctaacca taaacatttc tgtattctcg agcagctcag aaatatgttc 3283741 acctttttcc tcagccagtt gttgatggcg gtacaaatcc gcacaaaata caaaaaagtg 3283801 tccgttcttc tcaacgtaag gctgattccc agcaagcacg gacagctcac gttttttctc 3283861 aggatcagaa accccgataa tcgaatatgc ctgcacatag ctggatgtag acgcagcctg 3283921 cgcacttttc actaatgtat caatttcttc agctgtcaaa agctgatcag taaaagaccg 3283981 gattgaccga tgattcaaaa tggtttcgat tgtgttattc atcacaaaaa cctccttatc 3284041 actttttatc atatccgaaa aaaagtgatc tcaaaagtga aatgctctgc acaaaaaaag 3284101 acagcctctg taaaggctgt ctgcatatca agaattaaaa agataacttc tgtatttcgt 3284161 cagctgcaca cttgcattat atacaatccc aaatccgatt aacgtggaaa gtgtcgagct 3284221 tcccccatag ctgacaaaca gcagcggaat cccggtaaca ggcataatgc caatgttcat 3284281 tccgatattc tggaatgtgt ggatcacaat taacgccgta tagccaacgc aaaagaaaga 3284341 agcgaaacgg ttaaacggat gtattttgtc tatcagaaca acaagcctgt agattaaaaa 3284401 gaagaacatg atgacaacaa ttgcacagcc tataaagcca aatgactcac ctattataga 3284461 aaagataaag tcagtcgtac tctctggaac ataaaccttc aaattagaaa taccattacc 3284521 taaaatacca ccagatccta ttgccatgat ggcctggtca acttgccagc tgtcatttga 3284581 atcttcctgt gtctcatttg aagcagacac ccaagaagtg acccgcttaa tttgataatc 3284641 ctgtattcca actgatttag caacgtcagg aaagtttatc attactaata aaattaatga 3284701 aatgagtaag atacctgaac cagctatgat cgcaatcaat ttccaattta tccctgacat 3284761 aaaaaccatt acaagaacga taaacataca tattcccgca gtcccagcat cctgcatcag 3284821 gataagacct acaggaataa ctgcgacacc cgcaatcttt aataacaagt ggatatcatc 3284881 cctaagcgtc cgaactcctt taggatttgc ttttccaata actgaagcaa gcatcataat 3284941 caaaccaacc ttcataaact ctgacggctg tattgttatt ctaccgatcc taaaccaact 3285001 ttttgcccct ttaataacag gtgcaataga ctcgggactg attttaagaa taatcaaaga 3285061 taaaatacca atgataaaaa tatataaact taacttttca agctgttcta aatcaaagta 3285121 caaaagaact gtaatggcta cagcccccaa aagataaaac acaatttgct gaatccaatc 3285181 cgtgttccca tactgcccaa actgaccggc agcatatatt gatactacgc ttataataaa 3285241 aaacacacca aatataaaaa tcaaatcccc ctggtaaaag gggctttgct gtttcttata 3285301 tcgactcatt ctatcccgcc ttacattttc atcggaaaat cactaatgtt tattatacat 3285361 gaaccacgtt caagatgaca cgtgaagctc gcttcctttt atgttttttc agcatttgcg 3285421 gcgctttttc agctacacga aatatgacgt atcataaacc gaaatgtttc gattgacaca 3285481 aaacttttca aatgaaaaaa acgccatacc aatagaattt gttaaaaaac gaatgcgata 3285541 atgtgttatg ttcccaaata atgtgatacc tcatatagaa atagctaaaa attcagagcc 3285601 ccatgcccat acattctcct agcacattaa acgaaaaaat aagacgatag atccagtcca 3285661 tttctgcaaa aacacgtatc aatttctgga aaacatggta taataattgt aacagaatgt 3285721 tcaaaaaaca atcacaaaac agacacaact cagttcctct atttcatttt tgtaaacgtt 3285781 atcacaaaat gaaaggagac gggtatgatg gacatgtttt ttgcttactt attggttgcc 3285841 agcgcaacgc ctctctttat ttggcttgat aacaaaaaag tcgcactctc agctattccg 3285901 ccaatcattt taatgtgggt attcttcttc ttttacgcaa cagaaagcct ttctccactt 3285961 ggacacactc tcatgattat cttgtttgcc gttaacgtca ttgtcgctca tatcgccgca 3286021 tttatcattt acggccttcc gtatcttcgc agaaagcgaa gcagctgaag acagcaaaaa 3286081 accctcttcc actgaagagg gttttttgta ttattcgtta tggcctgaat gctctgagtg 3286141 ttcagcgcct ccaggaggat ttccgtccat atggtcacca tggtgatagt gagccgcgaa 3286201 aatccagatg gatccaagta cgataacgat cgcgccaaag aatccgaaca gcgtgtttcc 3286261 gacttggatc gtgccgtttt cgctctctgt catatgcatg aacatgagaa gctgcagcgc 3286321 cgcctgaatg aaggcgaagc cgaagataat ccaaagtttt gctgatgagc tcaggtcagt 3286381 atacactgca acccatagag ccagcagggt caaaacgata gacaggataa aacctacaat 3286441 gtgtttccat ggaaagtgac tgtgttcagc agatttgttt gccattttac agacccccca 3286501 atcccatgag atagacacct gtaaagatga aaatccatac aacatctaag aagtgccagt 3286561 acaagcttga gataaagatt ttagatgaag tttgcggagt taagccgcgt ttcttcaact 3286621 gaatcagaat tcctgtgatc cagaaaatcc cgattgttac gtgagttccg tgagttccaa 3286681 gtaaaacaaa gaatccagac cagaacgcac ttgtactgag agccgctcct tcatgtacat 3286741 agtgaacaaa ctcgttgatc tcgcatccga cgaagccggc accgagaaga agagtgataa 3286801 ttgtccaaat gactacgcct tttaaacttc cgcggcgcat ttcatgaaca gcgatcccgc 3286861 aggtaaagct gctgatcagc agcaagaacg tcataatcat taccagattg acttcaaata 3286921 gttcgtctgg caagacacct ccagctgttc tgtttttaag aacgaagaag gttgcaaata 3286981 gtgttgagaa caacacaatt tctgccccta aaaagatcca aaacccgaga atattaagtc 3287041 tgccggtttc agattgatat tccataggcg cgttagaatt gccgtgttct gcatgttcca 3287101 taactcacgc ctccttattc ggaaatcttt ctttccgtct cttttatttc atcaacacta 3287161 atgtagtagc cgttgtcgta ttcgaatgaa cgcagaacca tgcagagcag gactccgatc 3287221 aatccgacta cgcccatcca gtaccattca aagacaagtc caaagcctgc gagaccgaag 3287281 gcaacagaca taaagaacgg tctgcctgag ttgcttggca tatggatttt cttgaatttg 3287341 ctttcagggt ataattcagt tttttcttct ttcatatgca ggaatgcatc ttgagatttg 3287401 acttcaggaa gcaccgcaaa gttgtaatgc ggcggaatcg cagaagaagt cgcccaatca 3287461 agcgtacgtc ccacacccca tgaatctccg ctgatttcac gagtagagta acggaagctg 3287521 tagtagatgt tatagcaaag gattaagaat cctacaccca tcatgaaagc tccgactgtt 3287581 gagataaagt tcaatgttgt ccagccgtca ttcggtccgt atgtgtaaat acggcgcggc 3287641 atgccttgaa gccccaagaa atattgcggg aagaaacaaa tattgaaccc gatcataaag 3287701 atccagaaga accattttcc gattctttcg ttcagcttgt ggccgaacat ttttggatac 3287761 cagaaaataa atccggcgaa acaagcaaat acagtacccg caatcagcac atagtggaag 3287821 tgagatacaa ggaagtacgt attatggtat tgataatccg ctgctgccat cgcaagcata 3287881 acccctgtaa ccccgccgat aacgaagtta ggaatgaacg caagcgccca cagcataggt 3287941 gttgtaaagc tgattcggcc tttatacatt gtaaagagcc agttaaagat tttaaccccg 3288001 gttgggattg agattgccat tgtcgtaatt gagaagaatg agttaacgga cgcactgttc 3288061 cccattgtga agaagtggtg agtccaaact aagaaactca atacagagat ggcgataata 3288121 gaaccaacca tcgctttgta accaaacaat tgttttcttg caaagcttga gatgatttct 3288181 gagaaaatac caaacgccgg aagaataacg atatatactt caggatgtcc ccaaatccag 3288241 aacaagttag cccaaagcat cggcataccg cctgcttcca atgtgaaaaa gtgagcgccg 3288301 aacaaacgat caaatgataa aagtgctaat gctactgtaa gtacagggaa cgcaaacacg 3288361 ataataacca ttgtgatcag tgttgtccat gtgaacatcg gcatacgcat taatgtcatg 3288421 ccttttgttc tcatttttaa gattgttacc ataaagttga tccctgtcat cagggtaccg 3288481 ataccggcaa tctgaagtcc gaggaggtag tagttctcac ccggcccagg gctcatgtcg 3288541 ttacttgcaa gcggcatata actcgtccag cctgcgttcg gagaacctcc gataacgaaa 3288601 gaaatattga aaagcatcgc ccctacaaag aacgtccaga agctcaggtt gttcaagtaa 3288661 gggaacgcaa cgtcgcgggc accgatttga agaggcacaa caacgttgat aagaccgatt 3288721 aagaacggca tcgccatgaa gatgatcatg attgtaccgt gagttgtaaa aatttcatta 3288781 tagtggtttg agtctaaaaa actgttattc ggaagcgcta gctgggcacg catcatcaga 3288841 ccgtcgacac cgccacggaa taacataatt acagcagata taatatacat gattccgagt 3288901 tttttatggt caacagtagt tatccattca gaccacagcc atttccactt tttgaagtaa 3288961 gtcagaacaa aaataatggc aatggttgaa agcgcaatgg aaacttgtgc gcccagaatt 3289021 aatgggtcac cagttacgaa aaattcgtcc catttgaatt tcatgcaggc ttcctccttt 3289081 cctgatcaat atcattcttc tgtatcatca gacttcttaa attcgttttt ctttacgttt 3289141 tcaaacggat ctgttttaga atgcggtgaa acggcttgat agccaaggcg tttgcgcgcc 3289201 tccatcgcgt actcagcgtc ttgtccgtga tcaacgtatt tcaagtgagt agaagagaac 3289261 gttaattcgt ccacattttc aggaagcatc aattcatcat acttctcttt tgtcagctta 3289321 ggagcctcgt tctgagtctt tttcacccag ctgttaaagt ctttttctgt gactgcattc 3289381 acatcaaact cttggtctgc aaaatgttca cctgtgaagt tcgcgttgcg gccttcgtaa 3289441 gtacccactt tgtcagcctg taagtattga tccatcagca ttcctgccat cgcatatttt 3289501 tgccctccaa gctgaggaat ccatagcgaa gccattgaat ctgcagatga gattttgaac 3289561 aagatcgggc ggtcgacagg aatgtttaag tagttgaccg tttcaatatc ctgttcaggg 3289621 tagctaaata cccatttcca gtctaccgaa gtagcataaa caacaagagg ctctttgtct 3289681 tttgttgctt caggagcttt ttctaacgaa tatatcgtct gtactgttgg cacagaaagt 3289741 gcaatgacga ttaaaattgg gatcactgtc cagactactt ctaaaaacgt gttaccgtga 3289801 atttctgggt tataagatcc attatctttg cctttacggt cgcggtattt tactaaaata 3289861 atggtaaata gaacaaagac gaccccgacg ataaacagca taaatccgat agataacagg 3289921 attaaatcac tttgctgttc agctacaggt cctttcggat ctagtactga agcattgctg 3289981 catcccccaa ggacgaaaac cacagttaac agcgctaata caagcaacgg ttttaatgct 3290041 ctgaacaaga agatcaccat ccttcctatt gatgtaataa atctgaagtg catacttcct 3290101 caaaatcttt tctctacttt gttatgctat caaaaacttc acttattagc tttatttttt 3290161 tataaacttc atcccatttt cgcttaaatg tcataaaatc gacaaaaatt gctccaactt 3290221 tattcacatc tatcgcttaa gatgaaaagt ttctagttat ttccgcatat aaagtaaaga 3290281 aagatgatga agaactaatt ctgacaaatt aaggtttacc acaataaaaa acttaggtca 3290341 atcaaaaatt tcattttgtt aaactttcta gataggaatt attttttcct cgtctagcat 3290401 cttttcacac ggttaccatt ttaacgcatc aaatattgaa agaaaaggcg caatgaagag 3290461 ccaatatgct ctgaattgtc cgtatttttt tatgagagca tccagttgtt tatcttatac 3290521 aaaaaagagg aatgatataa gcaaataaat aaaaaatagg atgtgttgca tgatgagttt 3290581 tcttatttca cttatcgtcg ctattattat cggatggctt ggaagcctgt ttgtaaaagg 3290641 agatatgccc ggaggaatta tcgggtctat gatcgcaggt cttataggcg cctggatcgg 3290701 acacgggctg cttggaacat gggggccgca cctagccgga tttgccatta ttccagcggt 3290761 aatcggcgca gccattgttg tctttctagt aagcctgtta accagaaaaa gaggataaaa 3290821 gcagcagcac ccgaagcgtc agcgctttgg gtgtttgttt tgccataaaa atcgaaaaag 3290881 cctcaaccct agcggttgag gcttttgact ggtttggcgc ccaactgatc gatgaacctt 3290941 ctgaaggcct gttttccctc tgctgtctgc ttaaatacac cggcgtgttc aaggatgcgc 3291001 gcgaatacat gtcccagctc ttcttttatg actagatcta cgttctcttt tgttatggtt 3291061 cttttttcca tcgtccgaag agcccactca ctatgctttg cagtgagcgg attttgttct 3291121 aaggctgttt tcggatcagc agaacatagc gccgctgccg tttctttcat ttcctcctgt 3291181 aagcggccag gcaatatcgc caatcccatg acctcaatca ggccgatatt ttctttttta 3291241 atatggtgga cttcttgatg aggatgaaat attcctaatg gatgctcctc atccgtccgg 3291301 ttgttcctca gtacgatatc gagttcgtac aagtctcccc tgcgccgcgc aatcggtgtg 3291361 accgtattat ggggcgtatc gcctgtatag gcggcaatgc cggctttttc atcggaatac 3291421 gtctgccacg tgcggaagat atggtcagca gcttcggcga catgacccgg ttcgtctcct 3291481 tggagcctga gcacagacat cggccacttc actaagccca gcgacacgcc gggataatca 3291541 tttaattcat aaacgtcttc cgcttctgca cgtgccattg gaaaatcatg cgcgccgcct 3291601 tggaaatgat catggcttag gatgctgccg ccgacaatcg gcagatccgc gtttgaaccg 3291661 ataaaataat gcggatattg gccaagaaat gacagcagcc tttcaaatgt ttttttgctg 3291721 atctccatcg gttcatgttc accttttaag acaatgcagt gctccggata atagacatat 3291781 ggcgagaatt gcaggaacca ttgttcgtcc tcaaggatga ccggaatgat tctgtgattt 3291841 tgccgggctg gatgattcac gcttccctcg aagccgacat tttctttaca cagcaaacac 3291901 atcggataat ttgtctgttc ctgctctttt gcagccgcaa tcgctttcgg gtccttttca 3291961 ggctttgata ggttaatggt catttccagc tcgccatatt cggtcggcac cgtccaatga 3292021 acatttttgg cgattctgtc agtccgtata taatagacat cctctgaata ttgatagaat 3292081 tcctttgtcg cctgttttgg gccgtataat gcttttgtct cttcaaattt gcgaatgacc 3292141 tcggacgggg caggcacaaa acagcccatc agctttgcgc tgagcaggtc acggtacgta 3292201 tctgtatccg cttccattcg gccggtttcg gcagcccatt tatagatggg agctagcaag 3292261 tccggcaggc tttgtgactg cttgatgctg gtgctggagt tcggctcggg atgtgtgatg 3292321 cccagcgctt cataaagacg gtttctcgta tattcccgat cccagatcga aatcaatttt 3292381 cgttccaggc catactcaag cagctgttcc agatgttcaa taatactcat atgtcactcc 3292441 ccctttagtt ctctcgctcc ctctccgata tccgcgacat aaaagtccgc tcggagccct 3292501 gttttttctt gatatctgtc tccaaccttc tgaataaaat catcaacgaa ctcatctttt 3292561 acaatgctga tggtgcagcc gccaaagcct gctcccgtca ttcttgatcc aattacacct 3292621 tcgtgatccc atgccgcaaa cacaagctca tcaagttcag ggcatgttac ttcatagtca 3292681 tccttcaatg aaaggtggga ttccttcatt aactgcccga tttcatctat attgttctct 3292741 ttgaacatat gggccgtctt aatagcacga tgattttcgt atacagcgtg ctttgcccgg 3292801 cgtctgttcg tttcattttg gatcaggctg gaatgcgcat cgaaatcaga aggcttgatg 3292861 tcgcccagtg cggcaatatc gaggcctttt ttcagatcaa gcaatgcatc attgcattct 3292921 tggcgtctcg tattatagct ggagtcagcc aatgtccttt ttttgttcgt gttcgcgatg 3292981 accagcgcga ggcctgagac attgagtttg ctatattcat agtcaagcgt gtcacagttc 3293041 agcagcatcg catgatgttt tttccccatt ccaattgcaa attggtccat aattccgcaa 3293101 ttgacgccga taaaatggtt ttccgcatgc tgcgccattt tcacaagctc aagcgcatct 3293161 acttcaggat gaaaataact ttggagcacg acccccatca gcagttcaat agaagcggaa 3293221 gacgacagtc ccgccccgtt tggaatattc cctgaaaata caatgtcaaa gccatgggga 3293281 actgcatatc ccctctgttg aaattcataa atcacgcctt ttgggtagtt cgcccagtcg 3293341 tcttcttttt gatagcgaat gtcgtcaagg ctgcattcct tgatgcctgc gtttctaaag 3293401 ttatctgaat acatccggac aagcccgtcg tttctttctg caacagcagc atatgtaccc 3293461 attgtcagcg cgcacggaaa gacatgcccg ccgttatagt ctgtatgttc tccaatcaga 3293521 ttcactcttc caggtgcgaa aaaaaaccgt aacccctctt tttctccgaa tacacttgca 3293581 aatatcccct ttagctcttc ccgcatgtgc aatcaccttt ctggttttta ttttttattc 3293641 cccttatttc ttcatagaaa acggcagatc atatgctgca gtcctctcat accccttctt 3293701 cttttgtttt tttaaagacg agccatttgc tcgcaacata gttgacgaca acaatgaccg 3293761 cgttgtcgag tattttggcc aaggtttcat ttgtattgaa ctggccgaca agaatgatca 3293821 tcatgcctaa atctatgccg agagacagga cccgaacgct gaaaaaagca gtgagctctt 3293881 tcagcaggct ctgcagatca tgtgtttttt gctgaaacac atataattta tttgttatgt 3293941 aagcaaacag cacggacaaa atccaagcgg caacagtggc ggctttgtaa tccacattca 3294001 tgatctctac caatatataa aagctggcga tattcacaat ggttgtgaaa acccccataa 3294061 tgatatacat aattatttct ctatacttca ctgatgttcc tcgctttctg aaaaactttt 3294121 caaaattctt ggcctctcgt gctctctgtc taaagtaaaa aataccgaga gtgcgtctaa 3294181 aaagctgcgg aaggtggctg gctggcccaa tacatatgat tgtttgatga ttccgtcgag 3294241 gactgcacat attattttag ccgtatattc aggatcaata caggcgtcaa tcagctttct 3294301 ctccttcagc cacttaatat ataacacatt ttcttccacc cacaattcgt acagccggac 3294361 ataggccttg catttcttta agactttata tgtcggcatg ttcatggcaa acgaggtgat 3294421 gtcccacgac ggcttattta tgtaatagga ataaagcagt tctgcagcgt gttttgcagc 3294481 ctcgtccaat gtcagcgatt tcactgactc ccgctccatt tgatcaagat accctataat 3294541 gatctttttt ttcatctgac gtttttcgag aaggtacagc agaaaatcgt ccttgctgac 3294601 aaaatgaaca taaaatgctc ctttgctgta cccggcggct ctgctgatat cttctacaga 3294661 aaccggatca tacgctcggt caatcaacaa attcacgcca gcgtctataa aactttcaaa 3294721 tgttgcttct cttttaattt gaaatttgtt ttttttcata tttttctcct ggcggtaatg 3294781 attaccctta tcttacaccg gatcaatctt tagcggtatt tatttcttta aacggttatg 3294841 ctattcggtt tcccaggggt catttttaat aggctaaatg atttattttc atttacatac 3294901 tatccagtca gtatttaatt gtttattatt ataaataagg tccattggtt atattagtca 3294961 tttttttagg gaataggtag gtggtttttc cttcagtttg tgaacaccga gcaactatgt 3295021 gtgaaatttg ttgtactcgc ctccatcatc gcgctggctt gtcttttatt gcccgcatgt 3295081 tgcaggaaaa cattttatac aattggaggt tactatgaaa actcatgtta aaaaagattt 3295141 ggacaaaggt tggcatatgt taattcaaga agctagatcc attggattag gcattcatga 3295201 tgtgaggcag tttttagaat ctgagacagc atcaagaaag aaaaaccaca aaaaaaccgt 3295261 ccggcaagac tagtccgaac aggcggatct atttacctct ggcttttcta tcacctgatc 3295321 tgagttttca ccatatcctc tattcaaaag caaatcgctg cgctgagctt gaggacaaac 3295381 ggtgtgtcag ctaactacga cagacagccg gtgatgcgat cacctcttgg cacatgcatt 3295441 gtcataaaga ggtgatgcga acatgataac cgtgctctgg taaacagcag ctttgctgag 3295501 aacaagctgc attcggtgag gttttgaaag caaactcgtt tatacacggc cgagcttgaa 3295561 aaccttcgcc tgtctttaga ccactgtgtt cacctcttca cgacttcctt cttttttcat 3295621 cctccagcta ttgtacaacg cataaatcgg actttcagta catacctatt ggtgtacctt 3295681 tttgcttacg tttagcgaat aaaaggagga aagccatgta caaagctgat tataaacaga 3295741 ttgctgcaac gccgtctttt caagcttttt taaagcagaa acgcgctttt attgttcctt 3295801 ctgcgatttt cttttttgtt ttttattttt cactccctgt tttgacatct tatttcacct 3295861 ttttgaatgc accggccatt ggagctgttt catgggcttg gctgttcgcc atcgcccaat 3295921 tcgctatgac ctggatactg agtactgtgt attcccggag agccgcccat ttcgataagt 3295981 atgtaagcgc tttaaaagag gatctgaagg gtgaacagac atgaatatga ctgctttttt 3296041 attatttttg gcgattgttg gcctgacgct tattatcacg tattttgccg cgaagcggac 3296101 gaaaacgacg agtgagtttt atacggcggg cggcgggctc accggcgttc agaatggact 3296161 ggcaattgcc ggtgactaca tgtctgccgc ctcgtttctc gggattgccg gaatgattgc 3296221 gttatatgga tttgatggct tcttttacag catcggtttt ctggtggctt atctcgttgt 3296281 cttgtacatc gtggcggagc cgcttcggaa tcttggaaag tacacgatgg cagacatgat 3296341 tgccgctcgc tttaaagaaa agaaaatccg cggtgtcgcg gctctcaata ccattgccat 3296401 ctctactttt tatatgatcg cccagctcgt gggggcgggc gcgctgatca aactgcttct 3296461 agggctggat tataccgcgg ctgtcctcat cgtcggagtg ctgatgacca tttatgtcgt 3296521 gtttggcggc atgatcgcga caagctgggt tcaaattatt aaagctgttt tgctgatggc 3296581 cggcacactc gtgatttcga ttatcgtgtt ttcgaaattc ggctttagcc ttaataccat 3296641 gtttgaacag atgaaaacgg ctactccgct tggcgctgat tttttgaacc ccggaaataa 3296701 atacaaggtg ccgcttgaga ccttgtcgtt aaacttggca ctcgtgctgg gaaccgccgg 3296761 gcttccgcat atattgatcc ggttttatac cgttaaggat gccaagacgg cccgtacatc 3296821 cgttgtgtca gcgacatgga ttatcggtgt gttttacatt atgacggtat ttctcggctt 3296881 tggtgccgcg gcatttgtcg gttttgacgc gattacggcg gctgatcaag cgggaaatat 3296941 ggcggctccg cttttagcaa aagcgctcgg aggagacttt ctgttcgcgt ttgtatcagc 3297001 catcgccttt gccaccattt tggctgtcgt gacagggttg gtgctgtctg ccgcctcagc 3297061 atttgcccat gatatttaca gccagatcat cagaaaggga gaagcaactg aaaaagaaca 3297121 aatgaaagcg gccagatggg cttctgtcgc cgtgtcagtg ctctcgattc tccttgcgat 3297181 ttttgcacaa tccttaaatg tggcgttcct tgttgcactc gcgtttgcgg tagccgccag 3297241 cgcaaacctt ccgctgattg tgtttacagt cttctggaaa cgattcaatg cctcaggcgc 3297301 tttatggggc agcctgacag gcctgatcag cgcgcttgtg ctggtatcga tgagccctag 3297361 tgtgtgggac ccggccggag gtgctatttt taccggtgat ccgctcattc cgctatctaa 3297421 tccaggaatt atttccatcc cgctcggctt tctcggcgcg tggctcggaa cggtgctgtc 3297481 gtctgataaa acaattgatg aagatacgtt tgcagaaatt caggtgaagg cgcatactgg 3297541 cgtccatatg gaacaggaat aaaaaaagct ctctttatcg agagcttttt ccttactttt 3297601 tcttctgctc gtcagaaatc gctttttcaa atacatcctt gccggcagca cccggaatta 3297661 cagtgtcacc gataataaag gttggaacgg ctgtgatgtc agcctcttca taggcgtgct 3297721 tcaaggcttg gcgctgcacg tcctgatatg ttcttgtttc cagtgctgat ttgaatgatg 3297781 caccgtctaa tcccacttcc tcggcgagct tcgtcaagat gtcaatatcg ccgatatttt 3297841 ggtcctcctg gaaaaatgcc tgaaagacac gggtgttgta ttcatgtcct ttattgtatt 3297901 ccttcgcaaa atggaagcct tcaaacgcga ggtctgtata cggatggggc gagacgtttg 3297961 gaaaattgat ctcgactcct aatttctccg ccattggctg aattgatgtc tgccacatgt 3298021 actgtttaga aggatcattg accggatcaa gctgaggaga tgggcttggg cgcagttcaa 3298081 acggcatcca ctcgacttca acatcctttc cttttatcgc ttcttcaaaa gcggcttttc 3298141 caacaaaaca aaatgggcag acgtaatctg aataaacttt aatgtgtact gtcatgataa 3298201 tctcctttca tactaaattg attttaaact gtaacaatta aagttacaac tgttttttaa 3298261 taaagaagcc gatttaggct tctttcagat tgatgacaaa atcctaaaaa gttttaggat 3298321 tttgtcatcc tttcagcgtg attgaaaacc cttgaagtct aggaaagccg agcattggag 3298381 cggagcgaat gctctaattc gtgagcacca acgcacaggc ttgacaacga atgcgagggt 3298441 ttgtcgacac gctgaaagaa gcctgtaaag gcttctttta tgattccagc aaacgctggg 3298501 caatatattc tccttttttg cagccgcctg ggcatgcgta taaagcagaa ccgattgttt 3298561 gtgtatattc gtttaacgca tcctttgctg aaagagcctt cagcatcggg ataaactgat 3298621 tgtcgggatt tttttgaaaa ctgataaaca ggagacctgc atccatatag ccggttttcg 3298681 gatcaagtcc ttctgtgtaa gagaaagctc ttcgcaaaat ttgtttccca gtagatttcg 3298741 ctagactgac gtgtgaatta gacggaattt gattcagctt cacgggatct gtttcctttt 3298801 tctgcccaaa aggcgccccc gagctttttc tgcggccgaa ggtatcctct tggtccttga 3298861 gggaagagcg gtcccatacc tcaaggaaca ttttgatttt ccgaaaagcc atataggtgc 3298921 cgcccgtcat ccagtcaggc tcaccagact gaatccacac gatcgagttc atcaacgtgt 3298981 catccttcgt gctctggttg cctgttccat ctttaaaccc gaagaggttg cgcggtgttt 3299041 caccattttt tccaccgctt aaaaagcctt tgttcacaaa acggacctca caagtgccga 3299101 ccgcttgatt tagcaggtta cgcagcgcgt gaaacgccac ttgctcgtcg tctgcacaca 3299161 cttgaatgca gatgtccccg cctccctgct tttcatccag gttgtcattg ggcatcgctg 3299221 gaagagcggc taggtgcttc ggttttttgc ttttcagtcc gaagcggtcc tttccgtctt 3299281 tttcaaaaaa gccaggcccg aatccgaatg tgaccgttaa gttggaaggg gataaatcag 3299341 cagactcacc tgtatcctgc ggcggcagat actgatttct ctgctccgct gacattttct 3299401 tgccagacgt cagcatctgt gtgagacttg tccagtttct aaataacgta atgatgtcgc 3299461 ttttgtcttt tgctgttaca tccagtgcag caaaatagac atacgtctga tgggcagttg 3299521 tgattccggc ctgatgcttt ccgtaaaacg gaacaatctg ctcctcctct ttttcatcct 3299581 ttttcgatgg cttagccgca gtctgaacaa gcggagcgag accgccgaga ccgctggcac 3299641 cgatcgcaac ggctgccccc gccatcgctc cccattttaa aatgtcccgt ctgtgaattt 3299701 gttctggctt tttctgttca tcgctcatga tgttacaaaa ctccttttat agcacattcg 3299761 caatcttcga catggtttca gaaagagtcg tcagcttagt gctcagctct ctgatttgct 3299821 tttcacttaa tttatcataa gacgtatagg actgatcatt tgttttgtat tttgccatta 3299881 aaacttcaaa ttcgctgaac tccgtatcca gtttttccgt caagtcggag tgatctttta 3299941 caagcgcgct tttcactgtt tgataaacgg cttcggagcc ttccacattt gccataaggt 3300001 caactaaatc aattcgtgag tagcgctctt cttctcccgt gattttcgaa attccggctt 3300061 cgttcagaag ctccatcgcg cctgcaacaa tttgttcagg tgttaatttc agtgattgaa 3300121 ttgaaccgtc aagctctttt acatccttga gaagctggtc agctgttgcc ttttccccgg 3300181 aaatatcttg atccttccaa atggccttct caagcttatg gaagcctgtc catttgtctc 3300241 cttcttcaac atcgttttct cgtgcgtcaa ttttcggatc aagatctccg aggctttcag 3300301 cgatcggttc gattcgctcg taataaacac gcgctttcgc atataacgtt ttggactttt 3300361 cgatatcgcc ggatttcaca gcacccgtaa atgcttcagt cgctttgaca agctggtcac 3300421 tctgctcttt gacatagcct ttatactcat ccgctgcttt tgccagctga tcgctagcct 3300481 ttttgccgct cttcttcgct tctgtcaggt cttctaagga tgctttcaat gactcggatt 3300541 ctgtcttgat ttttcctgca tccggtttgt ctttttgcgc ttctgtgtag attggctgaa 3300601 gatgcttttc gatttctgta tattcgaatg gatagtcgct gcgaatatcg ttttcaaagg 3300661 aaagccagta gctgtttaac tctttcccct tcttttcaat ctctttttgg tctccttttt 3300721 ccactgagtc attcagctta gaaatgatgg tttccatttt atttacggat gcggtgattt 3300781 ctttagtgac cccgcttttt tcagatgaag ctttttcttt ggttgaagat gtgtcattgg 3300841 ctccgcagcc tgcgcacagc gcaaggatgc atccggctga tacagcgatt tttgtgaaat 3300901 tcattttgtc agttcctttc cgtttgtaaa atgttttgcc gcttctgaaa caagcgcaat 3300961 cagtaaaaag agtaaaatca acatttgcgg aatcgtgctg tacacagacg gataaattcc 3301021 tagcaccgat acagacggca gccagctttc tgcatcagac ggaagaatgc ccgccagttg 3301081 aaggctgtga acgccggttc cgagaaattt cacgcacata tacaggacaa ccgccattga 3301141 tagaagaaaa aacggcttca atggaatgcg cattccgagc ttgatcatca gaacaccgac 3301201 gatgacgaga acgataagcc ctgcggcagt tccgccgatc agttcagtga gcgggagctt 3301261 cccgacaagc ccgatgaaaa agatgaccgt ttcgagacct tctcttacaa ctgccagaaa 3301321 tgcaatgagc gcaaaggaaa gcaggcttcg tttttttagt gcctgtgact tctggatatt 3301381 gattttttct ctccatttat ccattgaggc gtttctgtgc agccacaccc cgacatacaa 3301441 aagcatgaca gcggacagta cgccggtaac gccgccaagc aagaaattgt tttctccgaa 3301501 tacactggag gagaacagaa ccgtgacacc gatgccggct gctaaggaaa cagccatgcc 3301561 ggcggacgcc ccgccccaga tccatgtcga ggaacgcgta acccgcgctt tttttgtcat 3301621 ggttaatagc gctccgatga caaggagggc ctccattcct tcacgaaccg ggatcagcgc 3301681 cgcatcccac cagctgtagc tgcttgaagc gatcggctcg agcaattgaa tcatttcgtc 3301741 aatttgcttt gatacctttt caggatggct gccgatctcc gccttcatca gcgccagatt 3301801 ttcctccgat gtcgtatagg cttctttcga ttgggacacg acatctccct caacagcgag 3301861 ccaggatgta actaaattgt cgattgcgga tgacgcttca tccaattgtt ttttttctat 3301921 gaactgtttt gtgtctttca agctttgtat ataggctgtt aaggacgccc ttgattgacc 3301981 tgaggatgtc tttttcagca cgacagcctg ctgataggtt tctaaatgag acgcaagctc 3302041 ttcaagctgt gttttgagct tacgtgcgtc ttgattgata aaagaaagag aaatcatcgc 3302101 gatattcgcg tccatttcac tgtgagaaga aaggttttct ttcttaatag aaggttcttc 3302161 ttttttccac ttcgccttga aggtgtcaaa cgtttgttgt gccgaatcca tatccccgtc 3302221 ttttacggat ttgatcattt gcttgtttaa ttgaattaat gcggcgatcg gatcatcttc 3302281 cgcatgtgcc gcagaaccga aaaccatcaa caagctgaat agaataagtg ccagcccccg 3302341 agccatcatg ttcctcctat aattgaaaat gattatcatt gtataacata atcatagcca 3302401 gttcctgtcc tttgtcaatt aaaatttgaa ggtctgaaaa ccttgatgga cagcaaaaaa 3302461 gctgtccttt tacagaacag ccctttgaag gaaaatgaac gattatcttc ctgttttata 3302521 cgtttgaatt tcctcacgaa acttgcgtgc agcactctca ggatcctccg cctgactgat 3302581 ggcgctgatc atactgacgc catcggcccc cgcttggata acaggtgcgg cattatctat 3302641 tgtgattccg ccgatgccga caattggaat gctgatgcct tggcggcgca ctgcttcgat 3302701 aagagataca ccctgtaccg ctctcgtatc ttttttcgtt tcagtcggat agatcggccc 3302761 aagcccgaca taatccgctc cgtcttcttc ggcttgcttc acctcagaca tcgtatgggc 3302821 agaaacgccg agaatcatat cacctatggc agctcttacc tctttcgcat ttgcgtcttc 3302881 ctggccgatg tggataccat cagctttcag attcagagcc aattccacat catcattgac 3302941 aatgaacgga acaccagctt cacggcaagc tgcctgcgct ttttcagcaa atttaatccg 3303001 agcctctcct gtcagcgcat ccccgccttt ttcacggaac tggtacaggg tggcaccgcc 3303061 ttttaacgct ttttgtacaa ctgtaacagg atcggctttc gtattgtttg accccataat 3303121 gaagtataca gataataact ctttcatcat ttcccgagaa atacgagtca tgagacagtc 3303181 accctttcta tagtcgccca ttcttggacg tcttgttcag taacagttga aagcttgttc 3303241 agcaattcaa tctgaaagct tccagggcct ttgtcagccg tctgctgtgc ggcaagctga 3303301 gcggcgaccc catacgaaga aatggccgca atagcagcaa acaatggatt ttcttccaca 3303361 gcgcaaaacg caccgacgac ggaagtcagc aggcaaccgg cgcctgtcac ttttgtcagc 3303421 agcttgtggc cgttatgaag ggtgtataca tgtgacgtgt cggctatgac atcaacttca 3303481 ccagttatcg caatgaccgt gtttagcttt tgtgccgcct gctgagccag ccggatgatg 3303541 tcgcctccac cttcacccgc atcaacacct ttgatcagcc aatcggtcac gccgacggta 3303601 tgggcaattt ccgccgcatt tcctctgatt gcagcaaggc gcacctcacg aatgatgtca 3303661 cgtgccgatt cagtgcggaa cggtgttgct ccggcaccga caggatcaag aatgacggga 3303721 acgccatgtt cattagctga ttttcccgcg atgatcatcg cttcgactga ctccttgctc 3303781 agtgttccga tatttaaaac gagtgcaccc gcaattttcg ccatatcggc gacctcttct 3303841 tttgcgtacg ccataacggg cgatgcgccg agcgcgagca ggccgtttgc tgtgaaattc 3303901 gttacgacat tgttggttat gctatgcacc agtgggctat gccggcggac agccgtaaga 3303961 cattttgctg ctgattgtgc atccatattt gcatcatcct ttactatctt ttttcgggtc 3304021 ccataaatac gatttcgtat gttcgagcca agctctggcg gcaaacgaca agtacctgtc 3304081 ctttctccaa ataatggcga ggtgccaagg gatgaccgga tcgacaagcg gaatgacttt 3304141 cactttttcc gggtcaaggc cgcggcagat ccgttccggc aaaagcccga tcccaaggtt 3304201 ggcggatacc atctcactaa taaaatccca ttgtgatgtt tcataaatga tatggggccg 3304261 gaacccagcc ttgatacatt ccgtcataat tcggttgtgc aggacaaaat cctctctgaa 3304321 gaaaataaaa ggctcgtcct tcaactcacg cagctgacat tctttctcat cagccagccg 3304381 gtgggaaggg tgaacgacaa gcattaaggt ttcttttacg attgtaaacg aatgaaagat 3304441 atcttcgttt gcgggaagga ccacaacgcc gatatcaaga gagccgtccc cgacaccttc 3304501 ttggactttt atagaaccgt cttcgactag ctgaaaggtg acattcggat agttttcacg 3304561 gaaatcgccg agcactctgg ggaaaaaccc cgatccgatc atcggcggca gtccaatccg 3304621 tacgtgccct ttcttgactt ccataatatc atttaattct gacgtcaggt tttgaaatga 3304681 tttaatgatt tcctgcgcct gcacatacat gctatgaccg gcatcagtca gttccacctg 3304741 cctgccgttt cggtaaaaca gttcaattcc gagctcttct tctaaatttt tgatcatttt 3304801 tgatatcgtc ggctgagaaa cataaaggga ttgggaagcc ttcgtaaaac tttttaaacg 3304861 ggcgacttcc aagaaatatg ttaaatggcg gatatccatg cgcttcaccc tttctataga 3304921 caaaaggaat acttcttatt cttaatatat attttaccta tagagagacc ttatgtacaa 3304981 taagtatata agggaggcat caatatgaaa aaactgttgc taaccgttat tcaaatcgct 3305041 ctgttattta tatttgctcg gctgattaat tgggtgacag cccttcttca tataaatatt 3305101 cccggcagta taatagggat tgtgattctt ttcacattat tgcactttaa cattatcaag 3305161 cttgaatgga tcgagcttgg tgcagcgtgg cttctcgggg agctgctttt attttttatc 3305221 ccgtctgccg tcggagtgat tgaatacgga gacattatgt cgaaatttgg tgtcagcatt 3305281 ctgcttgttg tcatcatcag cacgtttgtc gtgatggtgt ctacaggaac gcttacacaa 3305341 ctcatcgcaa agagaaagga gaaaaagcat acgtgttcat cggaattgta agtttgtttt 3305401 taacggtttt ggtgtattta ggagcaaaaa aggtatatca acgctttccg cgtgtttata 3305461 cgtcgccgct attggtgacg cccgctgtat tagtcggtct gctgctgctg gtgaatgtcc 3305521 cgtacgagtc ctataatctc ggcggcggat tgctgaccga tatgctacag ccggccaccg 3305581 tggcattcgc gatcccgtta tataaatatt tccctgtttt aaagaaatac gcagtggaaa 3305641 ttattttgaa tgtggccgtc ggttcatgca tcgcgattat ttctaccgct cttattgcga 3305701 aatggcttca cctcggcacc ggcttaattg acagcctcgt cccaagatca gtgacaacgc 3305761 cgatcgcgat gaacgtatct gaaatgatcg gcggtatgcc tgccgtcaca gccgtgtttg 3305821 tgattttaac cgctttgctc ggcacagtga tcggcccgat ggtcatccgt tatttccgca 3305881 ttgataacga aattgcgcgg ggcgtgctgc ttggcacaag cgcgcacgga gcgggaacgt 3305941 caaaggcatt tgagctcagc tctgtgtccg gcacgatttc cagcgtgtcg atgatcttag 3306001 ctgcgattat gacgctttgc gcggcgccgt ttttgctttc atttatgtaa aaaactgtcc 3306061 tctcgagggc agtttttttt atgtgcttcc ccttattgaa aagctggcga attccaatat 3306121 aatgtatttg tggataccaa aggaggcacc ctgatgcaca acttgcaggt gaggcggcat 3306181 tatgccgcgt taaaaggatt ttatttgttt gcttttctcg gtacgggcag cataattccc 3306241 ttactcagta tgtatttaac gaaggaacag catttaagcg gatcacaggt cggcttgatc 3306301 atgtcactgg gcccgattgt gatgattttc tttcagccgt tttggggcat gctgagcgac 3306361 tatacgcaaa aaacgaaagg cctgctggcg gtttgcacat caatcacagg catcattgga 3306421 ttagcctata ttgcatttga cagtttccct ctgtttattt tgattgcggc ctgttttgca 3306481 gcctttcaaa gcacgattat tccactttcg gacagcattt cactaaggta cacacaagaa 3306541 acaaacggca actacggcgg aatccgcctg tttggttctc tcggcttcgg tgtcgcggtg 3306601 tttgccatgg gacaggtgac gaaccagctg taccccattc acgtgatctt tatctttggc 3306661 tgtgcctttc tgtgcattgc tgccatattg gcttcacaag tgcccggcca gcagaaaaca 3306721 acaaaggtca atatccgcaa aggattccgg gagcttatca gcaacaaaac tttcctcatc 3306781 tttatgatca tcacctttac gacatttgct ccaaacttag cgaacaatac gtatttcagt 3306841 ctttttctgg acaaaagcgg cgcgtcactt tccgctatcg gcattttatt tttcatcggt 3306901 gtcatttcag aaattccatt tatgagattc gcccaaacat ttatagataa aatggggctg 3306961 ctcaacgtca ttatgctgtc aggcggagtc tcattattca ggtgggcgct ctatttcacg 3307021 gcgccttcac tatggatcat ttatgcgacg gtctttcttc agggagtggc catcggttta 3307081 tttatcccgg cggcgcttca atatgtgaaa aagattaccc caagacacgt tgaagcgacg 3307141 gcgctgacca tgtacgccgc cattggcaac gggttcggca actggttctg cacatttgca 3307201 ggcgggtaca tttttgacta cgtgtcgatc ttcgcagtct acttgctttt tggcattctg 3307261 agcatagcag gctttggcct gacattatat ttaatgaagg ctgaaaaaaa caaacataca 3307321 cttcatcagc cggctgttac ttttaaacca taatgactat aatgaacaaa agaaaggatg 3307381 tgcgttatga acgggcaaga gcgaaacagc atttcgaaag ggttgcaggt tgatattgta 3307441 ttgaaagcag atcaaaaaac aggaaaactg acgagaggga cagtgaagga tattttgacg 3307501 aaatcaaact ttcatccgca tggcattaaa gtccgtcttg aagatggccg catcggccgc 3307561 gaccagcaga tcgtttctac ataaaaaaaa gctgcccctg aacagggcag ctttttcatt 3307621 attttttctg cagaaggacc actttcaggt agttgccttc cggaaatgcc gaaatcgttt 3307681 tgaaatcctc cggcagcgta aattcctcaa tgatcgtgta gcgttcattt gtttctttaa 3307741 aggcggcatc aataaagcct ttgaacttct tcatgccaaa ggcgctgctg tttgtagagg 3307801 caacaatgac acccttgtca gcagtgatgg cgatcgtttc cttcagcagg tttttataat 3307861 ccttggccgc gctgaaggtg cgtttttttg tgcgcgcaaa ggaaggcgga tctagaataa 3307921 tcagatcaaa gcgcaaatcc ttttttgcag catatgaaaa atagttaaaa acgtccatca 3307981 ctttaatgtc gtgcgcttcg taatccagct tgttcacgct gaattgctcg atcgttttgg 3308041 caagacttcg atttgccacg tcgacgcttg ttgttttctc cgctccgcca agcgccgccg 3308101 ccacggagaa tgcacccgta taagaaaacg tatttaaaac ggttttccct tttgcatagc 3308161 ggtctctgat cgccttgcgc acatgtctct gatccaaaaa gatgcccgtc atggcgcctt 3308221 cattcagatc caccgcgtat tgaatgccat tctcttggat gatgatcggg aactcgcccc 3308281 ttctcccttt cacgaagtca tcatcttcaa cgtattgtcc agccgtgtcg aagcgtttct 3308341 tctcgtaaat cgctttataa tcaagatcca tctcatccaa tgcggaaatc agcatgtctt 3308401 taaaggtgta aattcccttg ctgtaccatt gaatcagcag gtagccgtca taatagtcga 3308461 tggtgacgcc gccgacaccg tcaccctcac cgttgaacag gcggaaagct gttgtatctt 3308521 gagcctcaaa tagtttggcg cgcgcttggg ccgcttttgt taatttgctg agaaaaaatg 3308581 cttggtcaat ctgttcatgt ttattgcggg taagcgtcca gccaacccct ttgttttgca 3308641 ggccgtaata gccccgcgcg agaaactcgc cgccgctctc agacacgata tcaacgaggt 3308701 ctccttcttt catgtgcccc gcactccctg cgagagcttc tttttcaata aggggatagc 3308761 ctttttttat tttggcagcg tgtgcttttt ttagggtgag tagcttcata tatgtcgtcc 3308821 tctttccgtt tgctttctct tatggtacca caaaacgcca agatgtctgc attgacagaa 3308881 aggaaaggtt tttctacgat agacaaaaag agttacgagg aggagcagca tggcaaaacg 3308941 aattgaccat acaggcatca tggtaagaga tattaacgcg tccatcacat tttatgaaga 3309001 ggtactaggc atgaaattga aggatcgcat cactcacacg aacggtgtaa tcgagcttgc 3309061 ttttcttggc tttgaagacg gcccggaaac agaaattgaa ctgattcaag gctacagcag 3309121 cgagcttccc gctgaaggaa aagtgcacca cattgccctg ctgacggatg acatcgcggc 3309181 tgaatataca aaagcggaaa aaatgaacgc aaaatttatc gacgaggaga tcacaacact 3309241 tccaaacgga taccgttatt tctatatcga aggccctgac ggtgagtgga ttgagttctt 3309301 tcagcggtaa aaataaagaa cgtacatttt gtgatgtacg ttctttttta tctataccaa 3309361 ctgatatacg ttgactcatc gcaaatcata gcttcccagc ccatacgctc aaccaattca 3309421 tggatgtttt tatctttggc taaaaagaca ttaatgaatg agtcatatac actcataaac 3309481 acaaaatcca ttttctcatc agttaaaacg agctctgttg cggcttcatc aagaaccgtc 3309541 cgcaagttgg cttcagttat gtccaaaacg ccgcggtttt ccacaatcgg ttctgcgtaa 3309601 taaaaccgat tggatccgtt cgcacctaat acctttacca aactcggaat atgaaaattt 3309661 gaaatatgat cctcactggg ataatagagg tctccattta tgttttcatg taacacctca 3309721 gccaaatcct ctctcgcgaa ctcgtccctt aaagcgccta tcgacgtcat taaagccagc 3309781 gccagctcag catgtgtttg aaagccgcaa gaagacataa ccttcttcca ggaaacagcc 3309841 ttgcctattc ctcttatttc attatcgttt ggataaatat gttcataatc attttttctt 3309901 tttgcattct cccatccttc aggcatttgg ataaaaggag aaaagataag agcagcagat 3309961 gagtattcaa ctggtacttg ttgtaagatt ggtgattcgt catctaacca tatataatct 3310021 agcatgcgca cctcctttac atattctaac attcctttcg tttgaaagag atgatcagcc 3310081 ctatgacagg ctgatcatct atcacatcac atttttatcc ccagattcaa ccgcactctc 3310141 ttcccgccat ttttgatgat cccatattct gaaaaacgga tagtagatag cacaggtgat 3310201 cagcagattt accagctgca taactgcgcc cgacaccttt ccgcctgtcg ccaggtaacc 3310261 tgatatgagc ggcggcatcg tccatggcac cgcgattccg gccggtcttg ccaccagccc 3310321 ggtgctcatg ccgatataag tcgcggtaat cgtgaggagc ggtgcgatga taaatgggac 3310381 aataaggagg ggattcatga caatcggcat gccgaaaatg atcggctcgt tgatattaaa 3310441 tagcgcaggg ccgattccta atcgtccaag ctgcttcatt tgtttgctgc gggagcgcac 3310501 aagcatcgtc aggacaagcg ccagcgtcgc cccgcttccg ccgacattga tccaaatttg 3310561 aaaaaactga gtcgtaaaaa tactcggcag cgcctcgcct gcttggaagg cgagacggtt 3310621 ggcatccatc gcgccgtacc aaatcggcgc catgattccg ccaatgatgg aagccccgtg 3310681 aatcccgcac gaccaaagca gcatctgcac aaattcagcg atcaggcttc cgccgagact 3310741 gccgccaagg atggaaagcg gtgtgccaag caggtctcct acgacattgt gcagactctg 3310801 aaaaggtgtc atttcaatca gaagacgcgc cagccatacg agaagcacaa tgataaagcc 3310861 gggaatcagc gcgacaaatg atttgcttac cgcaggcggc acaccgtctg gcattttgaa 3310921 gacgatattt ttttgaataa tgtaccgata gatttcggtt gaaaacaagg cgatcagcat 3310981 ggcgacaaat aagcccttgc tgccgagcag cgtgatcggg attccgcccc ctaccatgat 3311041 ggactccgtt gagccatgcg gtgtaaacgg cacctcaaac ggtgttgcca gcagaaatgc 3311101 ggcaattgaa atcgctccgg cagaaagggc atcgacacca tagctttctg ccagccgata 3311161 ggcgatccca aaagcggcaa tcatcgccat aatatcaaac gaagcgttaa caggatatcc 3311221 gagcttatcg gcccactcgt tcccaaacac actcgccatg aaatcagcat accccggaat 3311281 cggcaagctc gttaaaatca agaagacaga cccgataata atcagcggca tggtcaggat 3311341 aattccgtca cgcaaagcgc tgagatgccg ctgcccggca attttcccgg cgacaggcat 3311401 tattttttcc tccatcaccc gagtgaatgt gctcatctta aaaaccccct tttctcattg 3311461 ctttgtgaac aacctccgca atgttttctt tatcttattt tgaaaacgct tacaaattca 3311521 tttggaaaat ttcctcttca tgcggaaaaa atctgcattt tgctaaacaa ccctgcccat 3311581 gaaaaatttt ttccttctta ctattaatct ctcttttttt ctccgatata tatatcaaac 3311641 atcatagaaa aaggagatga atcatgaaaa acatgtcttg caaacttgtt gtatcagtca 3311701 ctctgttttt cagttttctc accataggcc ctctcgctca tgcgcaaaac agcagcgaga 3311761 aagaggttat tgtggtttat aaaaacaagg ccggaaagga aaccatcctg gacagtgatg 3311821 ctgatgttga acagcagtat aagcatcttc ccgcggtagc ggtcacagca gaccaggaga 3311881 cagtaaaaga attaaagcag gatcctgata ttttgtatgt agaaaacaac gtatcattta 3311941 ccgcagcaga cagcacggat ttcaaagtgc tgtcagacgg cactgacacc tctgacaact 3312001 ttgagcaatg gaaccttgag cccattcagg tgaaacaggc ttggaaggca ggactgacag 3312061 gaaaaaatat caaaattgcc gtcattgaca gcgggatctc cccccacgat gacctgtcga 3312121 ttgccggcgg gtattcagct gtcagttata cctcttctta caaagatgat aacggccacg 3312181 gaacacatgt cgcagggatt atcggagcca agcataacgg ctacggaatt gacggcatcg 3312241 caccggaagc acaaatatac gcggttaaag cgcttgatca gaacggctcg ggggatcttc 3312301 aaagtcttct ccaaggaatt gactggtcga tcgcaaacag gatggacatc gtcaatatga 3312361 gccttggcac gacgtcagac agcaaaatcc ttcatgacgc cgtgaacaaa gcatatgaac 3312421 aaggtgttct gcttgttgcc gcaagcggta acgacggaaa cggcaagcca gtgaattatc 3312481 cggcggcata cagcagtgtc gttgcggttt cagcaacaaa cgaaaagaat cagcttgcct 3312541 ccttttcaac aactggagat gaagttgaat tttcagcacc ggggacaaac atcacaagca 3312601 cttacttaaa ccagtattat gcaacgggaa gcggaacatc ccaagcgaca ccgcacgccg 3312661 ctgccatgtt tgccttgtta aaacagcgtg atcctgccga gacaaacgtc cagcttcgcg 3312721 aggaaatgcg gaaaaacatc gttgatcttg gtaccgcagg ccgcgatcag caatttggct 3312781 acggcttaat ccagtataaa gcacaggcaa cagattcagc gtacgcggca gcagagcaag 3312841 cggtgaaaaa agcggaacaa acaaaagcac aaatcgatat caacaaagcg cgagaactca 3312901 tcagccagct gccgaactcc gacgccaaaa ctgccctgca caaaagactg gataaagtac 3312961 agtcatacag aaatgtaaaa gatgcgaaag acaaagtcgc aaaggcagaa aaatataaaa 3313021 cacagcaaac cgttgacaca gcacaaactg ccatcaacaa gctgccaaac ggaacagaca 3313081 aaaagaacct tcaaaaacgc ttagaccaag taaaacgata catcgcgtca aagcaagcga 3313141 aagacaaagt tgcgaaagcg gaaaaaagca aaaagaaaac agatgtggac agcgcacaat 3313201 cagcaattgg caagctgcct gcaagttcag aaaaaacgtc cctgcagaaa cgccttaaca 3313261 aagtgaagag caccaatttg aagacggcac agcaatccgt atctgcggct gaaaagaaat 3313321 caactgatgc aaatgcggca aaagcacaat cagccgtcaa tcagcttcaa gcaggcaagg 3313381 acaaaacggc attgcaaaaa cggttagaca aagtgaagaa aaaggtggcg gcggctgaag 3313441 caaaaaaagt ggaaactgca aaggcaaaag tgaagaaagc ggaaaaagac aaaacaaaga 3313501 aatcaaagac atccgctcag tctgcagtga atcaattaaa agcatccaat gaaaaaacaa 3313561 agctgcaaaa acggctgaac gccgtcaaac cgaaaaagta accaaaaacc tttaagattt 3313621 gcattccaag tcttaaaggt ttttttcatt ctaagaacac cacacacaac ctttttccca 3313681 tccattgtac aggcttttca tactattgct atacagccat gaacagcata aaatgaacgt 3313741 tattacagtt atcaccacat atggcgggat tgtgactggg caggcaggca agacccaatg 3313801 atgcaaaggg agtattaatg cctaaaaaac agggcatttt aactcttctt ttcgtgttgg 3313861 gctcataacg gcgccttgga caacccccta ttctcatgct ccgtcgtcga cgcgggcatt 3313921 tttgtcattt tcagccggta tttctcactt ttttcatttt gattgtcaac ttttcatttg 3313981 atacgatgaa caagccgact tttcttcagc aaaggaggtt ttaattgctt gcataaagag 3314041 attgcaaaag aattactgct gctcgcagga ggaaaaaaca atattatcag catcagccat 3314101 tgtacgaccc gtcttcgttt tgatgtaaag gacgagacga aaattgatat acatgccatt 3314161 gagaacctgc aaggtgtgca gggcaccttt ttccgctatg ggcttttcca gattatcttc 3314221 ggagcaggcg tcgtcaacaa aatatataaa gaagtcgttc atgtatggga gaccgcgcct 3314281 tctgaagagc ctgtccacca gaaaaaagcc agccggaagc tgaaccctgc cgcagctttt 3314341 gcgaaaacac tgtccgatat ttttgtgccg attattccgg caataacagc aagcggcctg 3314401 ctcatggggc tgatcggcat gattaaggtg tttcattggt tcgctgccgg cagcccatgg 3314461 attaaaatgc tcgacctcgt gtccagcaca gcctttattt tactgccgat tttagtcggc 3314521 ttcagtgctg cacggcaatt tggcagcaac ccatacctag gggcagtgat tgcagggctt 3314581 ttgacgcatc ctgatctgct ggacccgtct atgctcggca gcaaaacccc gtcttcttta 3314641 gacatatggg ggcttcatat cccaatgatg ggctatcagg gttccatgat accgattctt 3314701 ctttccgttt ttgtcatgag caaaattgag aagctattaa aatcgattgt gccgaagtcg 3314761 cttgatgtcg tgatcattcc ctttattacg gtcatggtga cagggtgcct cgcgctgatt 3314821 gtgatgaatc ccgccgcgtc catcatcggc cagatcatga cacaatcgat cgtctatatt 3314881 tatgatcacg ccggcattgc tgccggagct cttttcggcg gcatctactc caccatcgtc 3314941 ctatctggat tgcatcatag cttttatgca attgaggcaa cgctgcttgc taatccgcat 3315001 gtcggtgtca actttttagt gccgatatgg tcgatggcga atgtggccca aggcggagcg 3315061 gggcttgcgg tattcctcaa aacgaaacaa tcaagcctga agaaaattgc gctccccgct 3315121 tctctgaccg cgtttttagg cattgttgag ccgattgtat tcggggtaaa tctcaaattg 3315181 atccgtccct ttatcggagc agccatcggc ggtgctattg gcggagcata cgtggttgcg 3315241 gtacaagttg tggcaaattc ctacggactg acaggcattc cgatgatttc aatcgtgctg 3315301 ccgtttggcg ccgctaattt tgttcattat atgatcggtt tcttgatcgc agccgtctct 3315361 gcttttatag ctacattgtt tctcgggttt aaagaagaga cagaataact ggatttattc 3315421 gatttcattc ataaaacggg ggatgaaagg acaaaaaagc tatgaaaatt aaaagaatct 3315481 taaatcataa tgctatcgtc gtaaaggatc aaaatgaaga gaagattctc ttgggtgcag 3315541 gaattgcgtt taacaaaaag aagaatgata ttgtcgatcc gtcaaaaata gaaaaaacct 3315601 ttatcagaaa agatacacct gactataagc agttcgaaga gattttagaa acattgcctg 3315661 aagaccacat tcagatttct gagcaaatta tctctcatgc cgaaaaagag ctgaacatca 3315721 aaatcaacga gcgcattcat gtcgcttttt cagaccatct ttcttttgca attgaacgcc 3315781 tgagcaatgg gatggttatc aaaaatccgc tgctgaatga aatcaaagtc ctttatccaa 3315841 aggagttcca gatcggctta tgggccagag cactgattaa agataaactg gggattcaca 3315901 ttcctgatga tgaaatcggc aatatcgcca tgcatatcca cacagcaaga aacaatgccg 3315961 gcgatatgac acaaacgctt gatattacaa caatgatccg tgatattatc gagattatcg 3316021 aaattcaact gtctattaat atcgttgaag ataccatctc ttatgaaagg ctcgtgaccc 3316081 atctccgctt tgccattcag catatcaaag caggcgaatc catttacgag ctggacgcag 3316141 aaatgattga catcattaaa gagaagttta aggatgcctt cctgtgtgcc ctaagcatcg 3316201 gcacctttgt gaagaaggaa tacggctttg agtttcctga aaaagaattg tgctacatcg 3316261 ccatgcatat tcagcggttc taccaacggt cagtcgcacg ctgagacaaa caaaaaacgc 3316321 ttttgatcat ctcaaaagcg tttttttatc tgatttattg gttgatcgcc ggattcccaa 3316381 tcgtattcca cttcgtatag gacatgtaat ggaaatactc atcgcgatac ggatgttttg 3316441 tattggagtt ccaaggcttt tctccgccgc agaagtgcac gattgccggg ttttctcttg 3316501 tttcattata ttgcttccgc cctaacagag tcgatggggt tttcagcttt aacatgatat 3316561 aggtttgagc gttccagcgc ggatgaagtt cataccactg atcatacaag atcgcattca 3316621 gtgcatcttg gtcatgcagc acaagaaagt cttcgtctgg gtgttcattg ataaagttga 3316681 tgactttttc tgtgatgttt tgctttctcc aagactcaaa atcaataatc atgatacctg 3316741 agttaaaata cttccctgta tcagtgacgt tcatttcttt caggcgttca tgctgccccg 3316801 catcctcaac agcggctacg gtgtatggcg caatgtctaa gtcccatagc ttagaaatat 3316861 cctctaggac aagcgcatca caatcgatgt aaatcattcg tttgatgctt tcatccttaa 3316921 ttaagtcggg aatcgaaatg cggtaatacg cggcttttgt aatatggctg ctctcaaccg 3316981 catgttcata catgttggta tccacttcta aaaactcaat cggcactccg aatttcaaag 3317041 tggtttcttc cagtcttttt ttgttatcag gcttaattcc gccatcaatg acgtataatt 3317101 ttacctctct ctcctgatcc atgttagtca ataaagaaac gaacatccca cctaaatgac 3317161 gagcataatt atcatctgcg catgatacga tatgcatgat ttcatctttc ctcaatggta 3317221 ttcatctccc tttttgttgt acaagttaca tacccttttt caaaaaaata aacacgttct 3317281 ccgacatttt tttaaacaga atgtgtgata caacaaaaaa ggtgtcattt tttgaagatg 3317341 cgataaagcc aataaagaat gaaaaagctt gcgattgtga tggcttcagc cgagacgata 3317401 taccacggcc atggcccgag aacatctaag agagaggaac cgcccggttt tttcgtcaaa 3317461 tacatataat tcgcgccaag ccagcgatca atcagaaaaa tacagacgcc gtacacatta 3317521 acaagcagga ctgtcaccca taacgagcgc tggcccattc tgtaggtgcc aatcacagcc 3317581 atcagcagac aggataaaaa cacagacccg tgagaaataa aaaagaggat atatcggata 3317641 tgcggaaatg aaaacatacc gaggtcagga gtggcaagag cctgaatcga actgccgatg 3317701 ccgacaaaaa acaaaaacac aaacagcttt ctgctttttg tcactaacat aatagctgac 3317761 aaatacaccg acaggtcact aagctggaga ggcaatgaag tgcgcaccga ccacctgtcc 3317821 gtggcgacca tccatatttg atagccgatt tgcgaaccaa gcaaaagaaa cacaaacaga 3317881 gaacgcaaaa accggctggc cctcggctgc ttgacctcat cttggaacaa aaacaacaga 3317941 atggccaaaa gggagataat cgctaacgtc actacatgct ctgtcgaaaa cagatgaaac 3318001 ggatcatgct tatagtcgga ttgaacatat ttttgcaaaa ctgcaccccc gttttcgggt 3318061 ttttgtttat tttggcgttg tttgggcttt ttttattcaa ccgatatatg ggcttgaagt 3318121 tcacaccaga ctctgttaaa attcgtttca tagctaatga ttctgataat ttaaggcagg 3318181 cctaaaaaat ggaacgttca catcaacatc agcagcttcg gaaggaagaa cacgatacac 3318241 tttctaagct caaacaaatg cccgtcgagt cactcaacct ggaagccatt tcgatcgcta 3318301 cgaatctgta tcggtctgca caaaggctcc gtgtcaaaat ggagactgag gttctttcta 3318361 cctataacct ttcttggacc gctttctcca ttctttatga tctatgggta tggggagcgc 3318421 tcgaaacgag aaaaatcgct gagctgtcag ggatatctac agctacagca agcaacgtga 3318481 tcaaaacgct cgaaaaaaag agtttttgcc gtaaaagcat cgacacaaga gatcggcgac 3318541 tcgtgtttgt ctcaatcacc gattccggca aacaagcgat cgaagaactc tacccggagt 3318601 ttcacaaagg ggaaacagag ctcattgcgg gaatgacgaa ggacgaacag aaaatattga 3318661 cagggctgct tagaaaggta gctgacaatc ttcatacaac ataagctttg acgggaatcc 3318721 agtagcggtt tgtctccctg tttcagagag ccggcggtag gtgcgagccg gcgcacaggc 3318781 aaacgtgaat tacctcccca agctttcttt gtgaacctta gtagcaaaga acgggaaacc 3318841 gttattcgaa tgagcggaag acaatgtctt caaccagggt ggtaccgcgt gcattgagcc 3318901 acgtccctta ttgggatggg ctcttttttg tgtttgtaaa aaaggaggaa aaatgatgag 3318961 aacatttgag cagctcacag cgtcacaaca aaaagaggta gaaagacagc ttcagctata 3319021 catgacaggc gcccacgaag tcataccgcc ggaggaatta aaggcaaagc tcgtgaaatc 3319081 aatttccacg ggcacgccgc ttaaaattaa gctcggatta gatccgtctg caccggatgt 3319141 acatttgggc catacggttg tgttaaataa gcttcgccaa tttcaagaaa acggccacat 3319201 tgtccagctg ttaattgggg atttcacagg aaaaattggt gatccgaccg gaaaatcggc 3319261 agccagaaag caactgactg atgaagaagt tcagcacaat gccaaaacct actttgagca 3319321 attcggaaaa gtgcttgatc cagaaaaagt cgagcttcac tataactcaa aatggctgaa 3319381 aacattgaat ctagaagatg tcattgaatt agcagggaaa ataacggtag cccgcctgat 3319441 ggagcgcgac gactttgaag aacgcatcgc catgcaaaaa ccaatctcac tgcatgaatt 3319501 cttttaccca ttgatgcagg gctatgattc tgtcgttctc gaaagtgata ttgaattagg 3319561 cggaacggat cagcatttca atgtcctcat gggacggcat ttccaagaac gatacaacaa 3319621 agaaaaacaa gtcgtcatcc ttatgccgct cttggaaggc ttggatggcg tcgagaaaat 3319681 gtcgaagtcg aaacacaact acattggcat taacgaacat ccaaacgaca tgtacggaaa 3319741 aacgatgtca ctgcccgaca gcctgatgaa aaagtacatc cacttggcga cagacttaga 3319801 gcttgaagag aaaaaacagc tcgtaaaaga cttagaaacc ggcgccgttc atccgcgtga 3319861 tgccaaaatg cttttagcca gaacaatcgt ccgaatgtat cacggagaga aagcagcaga 3319921 agctgccgaa cactcgttta aaacagtctt tcaggaaaac agcctgccgg aagatatacc 3319981 ggccgtaaac tggaaaggcg aaaaaacgat agcgatgatt gatctgctcg tcaagctaaa 3320041 gctcctctct tcgaagagcg aggcgcgccg catgattcaa aacggaggtg tacgcatcga 3320101 cggagagaaa gtaacagatg ttcacgccaa agcagagata agagagaata tgatcatcca 3320161 agtcggcaaa cgcaagtttt taaagctcca ataatctgat attccgaaac gcttatgacc 3320221 cttcattcat aagcgttttt ttgcaggtat aaagcactgt cttttcaaaa acgctctcca 3320281 tcttgcagga aactccttta gcatcccgaa atattcccca accatacatt taggggaggt 3320341 ttatttttga tgaaaaagct tttgactgtc atgacgatgg ctgttttaac tgccggcaca 3320401 ctgctcttgc cggcacagag tgtcacccct gccgcgcacg ctgtacaaat atcaaatagc 3320461 gagcgcgagc ttccattcaa agcaaaacat gcgtactcta ccatttctca gctaagtgaa 3320521 gcaatcggcc ccagaatagc cggaactgca gctgaaaaaa agagtgccct attgatcgcc 3320581 tcatcaatga gaaaattaaa gcttgatgtg aaggttcaac gattcaacat tcctgaccgg 3320641 cttgagggta cactgtcttc agcaggacgc gatattcttc tccaagcggc gtcgggctca 3320701 gctccgactg aggaacaagg gctgacggcc ccgctttaca atgcgggatt gggctatcaa 3320761 aaggacttta ccgctgacgc caagggcaaa atcgccttga tttccagagg agacctgact 3320821 tattacgaga aagccaaaaa tgccgaagcc gccggagcga aagctgtcat catttataac 3320881 aacaaagaaa gcctcgtgcc tatgacgcca aacctgtcgg gaaataaagt cggcattccg 3320941 gtcgtcggca ttaagaaaga agacggcgaa gcacttaccc agcaaaaaga agccacctta 3321001 aaactaaaag cattcacaaa ccaaacctcc cagaatatca tcggaatcaa aaaaccaaag 3321061 aacatcaaac atccagacat tgtgtacgtg accgcccatt acgacagtgt tcctttttcg 3321121 cccggagcaa atgacaacgg ctcaggtacc tctgttatgc tggagatggc gcgtgtctta 3321181 aaaagcgttc catctgataa agaaatccgc tttatcgctt tcggcgccga agagctcggc 3321241 ctgctcggct cctctcacta tgtagatcat ctatcggaaa aagagctgaa acgaagcgaa 3321301 gtgaacttca acttagatat ggtaggcaca agctgggaaa aagcgtctga gctgtatgtc 3321361 aacacattgg atggccaatc taactatgtt tgggaatcca gccgtacggc tgctgaaaaa 3321421 attgggtttg acagcctgtc tctgacacag ggaggatcat ctgatcatgt gccattccac 3321481 gaagccggca ttgattccgc taactttatt tggggagacc cggaaacaga agaagttgag 3321541 ccgtggtatc atacccctga agactcgatc gaacatatca gcaaagaacg cctccagcaa 3321601 gcaggcgatc ttgtgacagc cgctgtctat gaggctgtga aaaaagagaa gaaaccgaaa 3321661 accattaaga aacaaatgaa ggcgaaagca tctgacattt ttgaagatat caaataaaaa 3321721 aagacggcac ttgggtgccg tcttttttaa tccacttctt tcttaatccc cagcattttc 3321781 tcatctaggt aatgggcaat ctccgcggct tctttcagct catctgttaa ttgcttagga 3321841 acgtcattgt tcaatttata ataaatttta tgttcaaggc tcgcccagaa atccatcgcg 3321901 attgtccgga tttgaatttc tgctttgacg tattccacac ggttcgttaa attcacaggc 3321961 atctcaatga ttaaatgcag gcttcgatag ccattcggtt tgggtgtctg gatataatcc 3322021 tttaccttta cgattctcaa atcttcatgc tgcttcaaca cattcacgac attataaatg 3322081 tcagaaataa aggaacagat gatgcgcacg ccggcaatgt cgtgaatatg ctccttcatt 3322141 tccttcgtcg taatctcaca gccctttctc attaacttat tcacgatgct ttcaaagctt 3322201 tttacacggg attttgtatg ttcaatcggg ttgtgtccgt gaatgaggtt atattcctgg 3322261 ctgataattg agaactttgt atcgagcgca tctagcgcaa atttataaac taataactca 3322321 tttttccaat cttccattac tgtttttaaa tcgtccatat gtgttacaga taaatccatg 3322381 ttcgtcatct cctttaacgg aactttatcc gctgtccatg tactagacgt ccctgtctgc 3322441 tgcaaggttc tatgaatttt tttacaaaat gcggtcgatt gtaacaaaaa aagaccgcat 3322501 gaaacgagcg gtctttttta ttatcggaaa tagctgatca ataatccgat cgagagcagg 3322561 aatccgaaaa atgtatttgt ttgggctgtt gatttcattg cgacaatcat attcatcggc 3322621 atttcgttct ggacgaagcc cttcactgcc tgaaccggct taggcacgct caaaaagacg 3322681 acaaacagcc atgggcttgc ggcaccggta ataaccaagc cgacaaccca gatataagcg 3322741 acggcaaacg acgcagctaa cagagtaaca gctcccttat gccccatcaa aatcgccaat 3322801 gttttgcgtc cgcctttttt gtcctcttca atatcacgaa tgttgttcga caggttaatc 3322861 gcgccgacaa gaatcgcaat cgggatggaa atcaaaatgc tctgcatatt gatcttatct 3322921 gtctgaatga aaaacgaaat cagcacaaac accgaaccca tgcaaatgcc tgagaataat 3322981 tcaccgaacg gcgtgtacgc aatcggcagc ggcccgcctg tatacaggta gccgatcgcc 3323041 atgccgacaa ggccgatcag cgcaagccac cagctgctgc tggcacaaat atagacaccg 3323101 agcaaaatgg caatcccgta tgaggcaaga gctaattgca aaatcgtttt aggcttcatt 3323161 ccgtggcgta caatggcccc tccgattccg actgattctg ctgtatctaa tccgcgttta 3323221 aaatcatagt attcattaaa taagttcgtc gcgatctgga tccataggca agaaaacagc 3323281 atagccaaaa acagcagcag atcaaccttc acataaaaca tcgccaaaac ggttccgagc 3323341 agcacaggca caaacgatgc ggttaacgta tgaggacggg ttaactgcca aaggatctgc 3323401 cccatgcttt ctttttgcgg cgctgtctga ccctcaccct tatttgtttg gttcatcttc 3323461 ctcttccttt ctattaaaag gcttactttt tttcagccgg cagcttaata aaaaactcct 3323521 tttgcttcct tatctatcat aatgacttct cccttatttc acaagatacc gcaagaaggc 3323581 gttttctttc ttattatacg cttctcgccc tgatttcatt aggtttctgc tttcacttga 3323641 acgaacaggt acagaaaaat ttttttaagt acattacact ttttaaaagt taaaaagatc 3323701 ttttgactcc aggtatcttt tcctttatta tgaatcagct cgaaacattc cattcttgcc 3323761 cttgcaggta taaagattca ttttcaaaaa catacgccga tatattaatt tgagggagat 3323821 tagggaaaaa atgaaacttt ttgagcatct gatcgtcaaa taatcatgtg attgtcgaaa 3323881 aaacgggaag ggaatttttg atatgctgca attaatgaaa cagctgtatg aaaaacccgc 3323941 tgtcaagtgg acatgtcata caggctttta tttgatgata ctgcttgttt tgttttttat 3324001 gtatggtttt cacaccgcga ataccggttc atatatttat aacgatttct aattggagag 3324061 agaataacta tgaaactttt acatgctatt caaacacatg cggaaactta tccgcaaacc 3324121 gatgccttcc gctctcaagg ccagtcgctc acgtatcagg aattatggga gcagtctgac 3324181 cgcgcggctg ccgcgatcca aaaacgcatt tctggggaaa agaaatctcc tatccttgtg 3324241 tacggccaca tggagccgca catgatcgtt tccttcttgg gaagtgtcaa agcgggacat 3324301 ccttatattc cggttgacct gtctattccg tccgaacgga ttgcgaaaat tatcgaaagc 3324361 tctggagcag aattgctgat ccatgcagca ggactctcaa ttgatgcagt cggccagcag 3324421 attcagacag tttctgcgga agaactgctg gaaaacgaag gcggctctgt cagccaagat 3324481 caatgggtca aagaacacga aacgttttat atcatttaca cttccgggag cacaggaaat 3324541 ccgaaaggcg tgcagatttc cgctgcgaac cttcaaagct tcacagactg gatttgtgca 3324601 gactttccag tcagcggagg aaaaatattt ttaaaccaag cgccgttctc atttgatttg 3324661 tctgtcatgg acctatatcc gtgccttcaa tcaggcggga ctttacattg cgtgacaaag 3324721 gatgctgtga ataagccgaa agtcttattt gaagagctga agaagtccgg gctgaatgtg 3324781 tggacatcaa caccttcctt tgtgcaaatg tgcctgatgg atccgggttt ttcacaggat 3324841 ctgctgcctc atgcggacac atttatgttt tgcggagagg ttcttccggt ttctgtggcc 3324901 aaagcgctgc ttgagcgttt tccgaaagcg aagattttta atacgtacgg cccgactgaa 3324961 gcgacagtgg ctgtcacatc ggttgaaatt acgaatgacg tcatcagccg cagcgaatcg 3325021 cttccagtgg gcttcgccaa accagatatg aacattttca ttatggatga agagggacag 3325081 ccgcttcctg agggagaaaa aggagaaatc gtcattgcag ggccgagtgt aagccgaggc 3325141 taccttggtg agccagagct gacggaaaaa gcgtttttct ctcatgaagg ccagtgggca 3325201 taccgaactg gcgatgccgg ctttattcaa gacggtcaga ttttctgcca aggacgtttg 3325261 gattttcaga ttaaacttca cggctatcga atggagctgg aggaaatcga gttccatgtc 3325321 agacagtcac agtacgttcg ttctgctgtc gtgattcctt atcagccaaa cggaacagtt 3325381 gagtatctga tcgctgctat tgtgcctgag gagcatgagt tcgagaagga attccagctg 3325441 acaagcgcta ttaaaaaaga gcttgccgct tctcttccgg catatatgat cccgagaaaa 3325501 tttatctatc aggatcacat tcaaatgacg gctaacggca aaattgaccg aaaacgcatt 3325561 ggcgaagagg ttcttgtatg acgccttaca gctcgttttt attctttata ctgcttggca 3325621 ttcttcttct gccgacgatc attctcggct taaacggaaa aagatttcaa gcatacaaca 3325681 tgttcatatc tatcattata ttggctttaa ttttttcgca cgacttacac ggggtcatcg 3325741 cgctgtgcct gtttacaata tggcaggtgc tcctgatcag cggctatctg gcataccggc 3325801 agaaagcgaa cagcggcttt gtcttttgcg gagctgttat cgcgtctatt ctgcctttat 3325861 ttctgtcaaa aatatggccg tttctttcac acccgcagcc gcatcatccg ccgcataacc 3325921 tgatcagctt tttagggatt tcatatttaa cctttaaagg cgttcagctg attatggaag 3325981 caagagacgg actgctgaaa gaacagctgc cattgcaccg tctgctgtat ttcatcctgt 3326041 ttttcccgac gatttcctcc ggcccgatcg acagataccg ccggttcgtc aaggatgaac 3326101 agaaggcttg gacgaaagaa gaatacgccg acctgctgta tacgggaatc cataaaatct 3326161 tcatcggttt cctgtataaa tttattatcg gctacgcgat caatacgtac ttcatcatga 3326221 atcttcccgc aatcacgcac aataagattc ttgggaacct gctgtacatg tacggctaca 3326281 gcatgtattt attctttgat ttcgccggct acacgatgtt tgccgtcggg gtcagctaca 3326341 ttatgggcat taaatcacca gaaaacttta ataaaccgtt tatcagtaaa aatattaaag 3326401 atttctggaa tcgctggcat atgtctctgt cattttggtt cagagattat gtgtttatga 3326461 gattcgtatt ttggatgact aagaaaaagt ggatcaaaaa ccgtatggcc gtctcaaaca 3326521 tcgggtattt cctgctgttt atgctgatgg gggtttggca cgggctcgcg ccgcaatata 3326581 tcatttacgg cctctatcac gccgttctga tgacgtgtta caactttttc gagaagtgga 3326641 ataagaaata taaatggctg ccgtccaacc gctggacaac cattctcgct attgtgatca 3326701 cattccattt cgtttgcttc gggttttata ttttctcagg aaaaccattt catcaccacc 3326761 attaaaggag attagaaagc tatggatttt aaacaagagg tattagacgt tttagcagag 3326821 gtttgccagg atgacatcgt aaaggaaaat cctgatattg aaatttttga agaaggtttg 3326881 cttgattctt ttggaacagt agaattgctg cttgcgattg aaaaccgttt tgatatttta 3326941 gtgccgatca ctgaatttga ccgggacgtt tggaatacac ctaacaacat tgtaaatcag 3327001 ctgtctgagt tgaaataatg aaaaagcgtt ttttcggtcc aattattttg gcgtttattc 3327061 tattcgcagg cgccatcgca attccatctt catggctgac aggcttcatc accgataagc 3327121 gtgtgaaaga gtcagcaaca gccttgaatc cgagtatgtt tcaagggcta tatttacaag 3327181 atcagatgct caaagatccg acatatcttc cgatttacgg gtcttctgag ctttctcggc 3327241 tggacgagtt ccacccatct aattattttc aggtaaacaa tgagggattc acgccatacc 3327301 ttgtcggcaa aggcggatcc cagtcattga ttcattcttt aaacttcgct gcccacatgg 3327361 atcagctgaa gggcaaaaaa atcgtattca tcgtgtctcc gcaatggttt attaagcgcg 3327421 ggtctgatga acagcatttc gcgccgaact attctgcgct gcaagggctt gatttggcat 3327481 ttaacgatca gatcgatcct gaaattaaaa agaaaatgat gaaacgcatg cttcgcttta 3327541 aggctgtgca aaacgatgcc attctttctg agctgtacaa agcaatggta aacggtcaga 3327601 cgtggaaagt gaacgcgctg aagccggcgg cgaaagtgta ttacagcatg ctggaaaaga 3327661 aagatctgta ttattcaacg acagaatcat ccgggccaaa gcgctatatc tcgcagtcag 3327721 taaaggataa gtcatggtct gaattgaata aactagcgga tcaatcgggc aaacgccact 3327781 ccggttctaa cgattttcac atcgacaacc ctgtctataa aaagctgaag ccgaaagtgc 3327841 ctaagctgaa agggaaaaac aaaggaagat cgtatgcggt gtcaccggaa tatggcgact 3327901 ttgaaatgat gctcgatatc ctgaaggatg cgggcgcaga gcctatgttt gtcaccattc 3327961 ctgttaacgg gaaatggtac gattacacgg gcttcccgaa aaaaggacgc actgactatt 3328021 acaaaaaggt aaataaacaa atcagagcga agggcttcca ggttgctgat ttctcagggc 3328081 atgaatatga cccgtatttc atgaaagaca ccattcacat cggctggaaa ggctgggtgt 3328141 atgtcgataa agcaattgac gaattttata aaaccggaaa agtcacttca tcctgagcat 3328201 ctcataggac gcggctgcat atttcctgct aagatttgta atagtaaagg aatcacagcc 3328261 aacttaatta agaggtgtta catccaatga agatgacaaa taatacggtt ttaatcacag 3328321 ggggttctgc tggcatcggg cttgaactgg ccaagcgcct gctggaactt ggcaatgaag 3328381 ttatcatttg cggacgcagc gaagcacgtc ttgcagaagc gaagcagcag ctcccaaaca 3328441 tccatacaaa gcaatgtgat gttgcagacc gttcgcagcg ggaagcattg tatgaatggg 3328501 ctttaaagga atatccgaac ttgaatgttc tcgtcaacaa cgccggcatt caaaaggaaa 3328561 ttgactttaa aaaagggaca gaggagcttt ttgtggacgg tgatgaaatt gaacttaatt 3328621 tccaagcgcc tgtccattta tccgcccttt tcacacctca tttgatgaag cagcccgagg 3328681 cggcaatcgt tcaggtcaca tccgggcttg cgtttaaccc gttagctgtt tatccggtgt 3328741 actgcgcaac aaaagcggca cttcactcgt tctcgcttac gctcagacac cagctccgcg 3328801 acacgagcgt ggaagtgatt gaaatggcac cgcctatggt ggacacgggc ttaaaccaaa 3328861 aatcacgcga taaacaaggc ctgacgtacc ggggcatttc atctgaagaa tatgttcaat 3328921 atttcttgga cggcttgaag gaaggcaaac aggagattac aaatgaacgt gttgaaggtc 3328981 ttcgggatgc cactcgcgcc gattatgaca ggttattcga gcaaatgaac acgcaggaga 3329041 attaatttct cctgcttttt tcatatgaat ttcttacaaa tttgagcaaa cctattgcga 3329101 ttatttgttg aaggtataca atagaatata attattttca aataagtttg ataatataaa 3329161 caatttaaca gcagggagat tgaccatgac taaacaaaca attcgcgttg aattgacatc 3329221 aacaaaaaaa ccgaaaccag acccaaatca gctttcgttc ggaagagtgt ttacagacca 3329281 catgtttgta atggactatg ccgcagataa aggttggtac gatccaagaa tcattcctta 3329341 tcaaccctta tcaatggatc cggctgcaat ggtctatcac tacggccaaa ccgtgtttga 3329401 agggttaaag gcttacgtgt cagaggatga ccatgttctg cttttcagac cggaaaaaaa 3329461 tatggaacgc ctgaatcaat caaacgaccg cctctgcatc ccgcaaattg atgaagaaca 3329521 ggttcttgaa ggcttaaagc agcttgtcgc aattgataaa gactggattc caaatgcgga 3329581 gggcacgtcc ctttacatcc gtccgttcat catcgcaacc gagcctttcc ttggtgttgc 3329641 ggcatctcat acgtataagc tcttgatcat tctttctccg gtcggctctt attacaaaga 3329701 aggcattaag ccggtcaaaa tcgctgttga aagtgaattt gtccgtgcgg taaaaggcgg 3329761 aacaggaaat gccaaaaccg caggaaacta tgcttcaagc ttaaaagcgc agcaggtagc 3329821 cgaagagaaa ggattttctc aagtactctg gctggacggc attgagaaga aatacatcga 3329881 agaagtcgga agcatgaaca tcttcttcaa aatcaacggt gaaatcgtaa caccgatgct 3329941 gaacgggagc atcctggaag gcattacgcg caattcagtc atcgccttgc ttaagcattg 3330001 gggccttcaa gtttcagaac gaaaaattgc gatcgatgag gtcatccaag cccataaaga 3330061 cggcatcctg gaagaagcct tcggaacagg tacagcagct gttatttccc cagtcggcga 3330121 gctgatctgg caggatgaaa cactttcgat caacaacggt gaaacaggag aaatcgcaaa 3330181 aaaactatat gacacgatta caggcattca aaaaggcgct gtcgcagacg aattcggatg 3330241 gacgaccgaa gtcgcagcgc tgactgaaag caagtaagaa aaaagccggc ccattacagg 3330301 ccggcttttt ttacgcttca attttgttga aaaactgcgg cagatacgct ttgtgcgcct 3330361 ctagcatttc gtctaaaatc tgtttggcca cagtatcgga cgggacaagc gggttaatcg 3330421 tcatggcaag gagcgcagtt tgatagtcac ctgtaactgc cgcttctgcc gcgacacgtt 3330481 caaaggattt gatttgctgg acaaggccgc ggacagacac cggcaagtcg ccgacagcaa 3330541 ttggcttagg gccggttttc gtcatcacac agttcacttc aactgcggaa tcgtctggaa 3330601 tactcgctat tgcaccatta ttgatcgtgt tcaccggctg aatgtcatgt ttatcattat 3330661 aaatggagct gattaagtta catgctgcat cactgtagta agctccgccc cgtttttcca 3330721 gctgcggcgg tttgatcgca aggtttggat ctttataaag ctcgaacagc tctttttcga 3330781 ccttctgtac gacttcagcg cgggtgccct ccgtttgtga tgcttccagt tcgtgctcca 3330841 gcatctcttt tgttttaaaa tagtaacggt gatagccgca agggatgaca ttgagcgctt 3330901 ttaagaaatc cggttcccat tcggcgcctg agatattttt catcgtcatc gcgtttttcg 3330961 ggtcgcccat cgcctcgatg acttgctcct tcacacttac gccgtccaag aaaacatcca 3331021 gcccgaatac catatggttc agtccggcaa attggacttc tacgcggtcc acatctacat 3331081 caagcgcttt ggctacgccc attttgatgc cgattggaac attgcaaaga ccgacgactt 3331141 tcttcaggtt ggagtagcga agcaaggctt ctgttaccat gccggcaggg tttgtgaagt 3331201 taacaagcca agcgttcggg caaagctctt ctatgtcctt tgcgatctca aggatgaccg 3331261 gaattgtgcg caatccttta aacagacctc ccgggccgtt tgtttcctgg cctatcactc 3331321 cgtattttag cggaatgcgc tcatcctttg ctcttgcctg caaaagtccg acgcggaatt 3331381 gggtcgtgac aaagtctgcg tctttcagcg cctttctccg gtcgagcgta agatgaatgt 3331441 caatcgggac gccagctttt tcaaccatcc gtttggcgag tgtgccgaca atattcagct 3331501 tttcttcgcc ctcggggata tcgacaagcc ataattcacg gacaggcagc tcatcatacc 3331561 gtttaatgaa cccctccact agctcgggcg tatagcttga acctccgcca atcgttacaa 3331621 tcttcaatcc ttttgtcata tgcttgctcc cctttgctcg gtgatttttt catataactc 3331681 aatgatctct gcagccatat ccttcactgt cattgcattc attaaatgat cctgtgcatg 3331741 aaccatcaga agcgtcattt ccgtcttttc tccgcccgct tcattttgga tcagctctgt 3331801 ctgataatga tgggcttttg acaattcttc agcagcgtct tgaagctttt tccgcgcttc 3331861 ttctgcgtca ccgcttttcg cagcggcaat ggcctccatt gcggagctcc taccgtttcc 3331921 tccgtgaagg atgatttgaa aaatgatttg ttccatttcc tcattcacgc gattcacttc 3331981 ctttctctac agagccgctt ctttgtcatc tgttgctgca ggcgtttgga ccagctccag 3332041 atcgttttct tctttcagct tctgcttatc ccacattctg aagaatggat agtagacaac 3332101 aaaggacacg gcaatattaa tggcttgcat gaccgcgcct gagacttttc ctcctgtcgc 3332161 caagtagcct gaaaagatcg gcggcatggt ccacggcact gcgatacccg ccggtttggc 3332221 gacaaggccg gtgctcattc cgatgtacgt gagtgtcact gtgacaagcg gcgtgatgat 3332281 aaacggaagt aagagcattg ggttcatgac gatcggcatt ccgaatataa tcggttcgtt 3332341 aatattgaag atggccgggc cgaccgcaag cttcccgagc tgcttcattt gtttgcttcg 3332401 ggcgcgcagg aacatcgtga caaccagtgc caatgtggcg ccgcttccgc caatattgac 3332461 ccagatatcg aaaaattgct gggtgaaaat cttaggaagc tcctcaccgg cttggaatgc 3332521 gatccggttg gcatccattg cgccgtacca aatcggtgcc atgacgccgc caacaatgtt 3332581 tgcaccgtga aggccgcagg cccataaaag cattttgacg gcttcggcga caaggcttcc 3332641 tccaaggctt cctcccagaa tggaaagcgg agtccccaat aaaacgctta caatattatg 3332701 aaggctttca aacggtgtcg cttcaacaat cagccgggct gcccaaatta ggaagatgac 3332761 ggcaaagccg gggattaacg cgacaaatga cttgcttacc gccggcggga caccgtccgg 3332821 cattttgaag actaaattgc gctggataat aaggcggtaa atctctgtgg acaccattgc 3332881 gataatcatg gcgacaaata agcctttgct tcccatgagc gaaagcggaa tcccgccgcc 3332941 aaccatgatt tctttcgtcg cgccatccgg cataaacggc acttgataag gtgttgctaa 3333001 taaaaatgcc gcaagggaaa tggctccggc cgacaaggca tcaacaccgt atttctcggc 3333061 gagccggtag gcaatgccga acgcggcgac aagacccata atttcaaagg tcgcgtcgac 3333121 tgggtaggcc agtttttcag accaggagct gccaaacgtt tttgccataa actcagcgta 3333181 tcccgggatc gggaggttgc caatgatgag gaaaaaggaa ccgatgataa tcaggggcat 3333241 cgtgaggatg ataccatcac gcagcgcctg caaatgacgc tgtcccgcaa ttcttcccgc 3333301 tataggcatg accttttctt ctaagatctg attgacttta ttcacatagc ccgcccctct 3333361 ctatgacaca tgtccaagct gttcagctga tttcagcact tccgccccat tgcacgttcc 3333421 ataatggacg gtattaatga cgtctaccgg aacccccttt gactctccta attttttgag 3333481 ctgcggaagc atgtaacgga cttgcggacc gagaagcaat acatccgctt tatcgatatg 3333541 attttgtaca gaatcgcctg aaactgccca aatggtatag tcttttccct gttcctgcgc 3333601 acttttttcc atcttgctca ccagtaagct agtagacatg cctgctgcac aaacgagtaa 3333661 tatattcatg taaaagaccc cctagagttt gatcaatttt gtaatgtcct gctgttgcta 3333721 tcatcatatt atgaaatcgc tttcataaac actcagggtt tttccgcagg caacggaaaa 3333781 aaggtatata caggctgtca gctcagcatt ttttggtcaa acacatccga aagctcttga 3333841 tatgaacggc atttgatcag ctggttcatc gccgccgggt catccaaaat gctgccaagc 3333901 agtttataca tgctttgtaa atccgctttg ttctcctttt cgacacaaag cagacagaca 3333961 aattgaactc gctgactctc ccaatcgatc ggttttttga gcgtacaaac ggcccaaaac 3334021 gttgttttcg tctgcggaac aagcgggtgc gggatggcaa caagattgcc aaaacacgtt 3334081 ggcgacatgt cttctctttc aaaaatggaa tctatgattt cttcatcggc aaagccgcat 3334141 tcgaccactt tctgccctaa aaattgaatc acttcttctt ttgagcgcag atcctcctga 3334201 aaaaaaacga gttctttttt taggtagcga ttggcttttt ccttttcatc actcagaata 3334261 gattctattt ttgtaaagtc agttccgcct aagatggtgt taaccttcag tactggtaca 3334321 gggagctctt ttttaatcgg aatggtgctg atgacaaaat caattgattc gtaggacatt 3334381 tgatcaagac tataatactc agccgttcca agaatatcga gccgcttgcc gaaatgggaa 3334441 cgcagttttt cgcgcagaag ctgggcgctt ccggctcccg atgcgcatac aatgatacag 3334501 cgtttcggcg ggctttctgt tttttttcgt tcaatcgcgg cgccaaagtg gagagccaaa 3334561 tatccaattt cgttttcatg aatctcaata cccgtttgtt cctttatcac gattccggca 3334621 atgatcccgg cttcaaaagc gagtggataa tgttccttga tcgctgccag catcggattt 3334681 cgaagattca tgccgtatcg gttgcggctg atcgccggct tcatatgcag tgccaagccg 3334741 attttcagct ctttgtcatg caggatgcca agcttcagtt cacgatcaac agctttgatc 3334801 atggcaagtg tcagctgatc ggtttcctct tctattgaaa atgtgtcctc tccgcattgt 3334861 gattgtgtca ttcgttttgt gccaaggaga tgcatggtga tgtaggccgt ctcgtctttc 3334921 ggaaacgtaa cggaaagctt tgattccagc tcttttacga tggcttctgc agcctggtac 3334981 tccttttgat gcaggatatg atccatatct ttcgggaaaa gagaaacata gttttccgtt 3335041 ctgatccgtt tacaggcgat agcgatatgg ataatgaggt tattcagtcc catgttggac 3335101 agagggatgc ggtcgttttt catttttttc aagatggcgg aacggatgat ctcaatttct 3335161 tcttttggca aaatatcagc cttttcattt aaaacatcta tctccgtttc tctttcatca 3335221 acaatgtact ccgccatgca gtacctcatc tgcacctcgt ccccgcgcag cttgaagccg 3335281 taattcggac gtgtttccat gacgatgcgg taaggcagca gacgtttctt tacttccttt 3335341 aaatccgttt ggagtgtaga ttttgagata aatagttctt cagcaagttc atcgagcttg 3335401 agataatggt ccgccagcag cagacgtttc ataagatagg ccattctctc ctccggcaat 3335461 accggcaggc cctttttttg ctgaaattca tcttgcagca gtgttctgaa tacttgctcg 3335521 tcatcaatgc ggagcttgta gccggagcct cttacagatt gtacaaaggc accgtggccg 3335581 cttagcacac cttgaagttc ctttatatca ttgcggactg tccgcgtcgt tacgtttaat 3335641 tgcgcggcaa aaaacgaact tgtcaccggg gcttcagccg ccatcagcaa gcgcagaata 3335701 tcacgtagtc gcccatgaag catgagaaaa acctcctaac tagtagatgc agggattcag 3335761 tgaataggca gaaaggatga tgaagggatg cgaaatgtat ataaattcta taatggagag 3335821 aatggcaagt caatgaacat ccggaggact agagggaaaa ctgacctata aaaaaacagc 3335881 cgggatcagc cggctgttct agatgcggac atattctttt gtttagacgc cttgcggtcc 3335941 ttcatgattt ttcgaacaat cgggtaaatg accggcgccc atttgataac ggttttgatc 3336001 atctttttca aagctccgat tctcccttct tttttctcaa ccattcccct gattgcctct 3336061 tccttaaaca tgctaacgcg acacgtacct gtttcccgtc acccagaaac gccatggata 3336121 atcgcgtgcc tccccgctgt tgtcaatgcc gatgcgcggg ccggttgaaa ttgcttccgg 3336181 tgtgtacccg ctttcgatgt aaagcggctg ttccgtgatc cagcgtccgt agtcattcat 3336241 cgtgacgcca agcgctttcg tcagctttcc tggtccgttt gtccattccc tcggactcct 3336301 gcccggcctt ctctcctcca ttaacagctg gccttcatgc ggctcaatcg ccctgattaa 3336361 tactgcttgc gggacatcct cttccgccgc aacgacattc agcaatgtat gggtgtgcat 3336421 cacgtatgta tatacccgcc cagcttctgc aaacatgatc tcagtccgct tcgtccggcg 3336481 gttgttaaag ctgtgggccg ctctgtctcc agcccccata taggcctctg tttccacaat 3336541 atagcctgac gctgtgcctt cgtctgtttc ttttacaaga aggcagccca gaagcgatgg 3336601 ggcaagctca agagcggttt tttgataaaa cgtgatgggc agcggatttt tttctctcgt 3336661 cacgaatcga cctctccttt taccgatttt tgtacattgt accattcccg aagcagatca 3336721 aaaaaaacgg ctgttttaaa atctttccat tcagggaata ttgttaccgt tcaaaaaagg 3336781 agggccaacc attgaaagat gatcatcaaa acaagcagca ccaatcaaat gcccaaggga 3336841 gcgaggaagc gttttctcat aagacatccg ggaaaaacga gtcagaggat accttaacga 3336901 ataggcaggg gcatcctgtt actgacaacc agaatgtgag aaccgtcggg aatagagggc 3336961 ctacaacact tgagaactat gattttctcg aaaagatcag ccacttcgac cgggaacgca 3337021 tcccagagcg ggttgttcat gccaggggag caggtgcaca tggatatttt gaagcgtacg 3337081 gaagcttcgg agacgaaccg atttcaacat acacaagggc caagctcttt caggaaaaag 3337141 gcaagaaaac accggcattt gtccgttttt caactgtgaa tcatggaaaa cactcgcctg 3337201 aaacattgag agacccgcgc ggttttgctg taaagctata tacagaagac ggaaactggg 3337261 atttggtcgg aaacaacctg aaaatctttt ttatccgcga cccgctgaaa tttccggatc 3337321 ttgtacacgc atttcagcct gatccagtga caaacatcca ggatggtgaa cgtatcttcg 3337381 atttcatttc tcaatctcct gaagcgacac acatgatcac cttcttgttt tcgccttggg 3337441 gcattccggc caactaccgg caaatgcagg gttcaggcgt acatgcctat aaatgggtga 3337501 atgaggaggg caaggccgtt ctcgtgaaat accattttga accgaagcag ggcatccgca 3337561 acctgacaca gaaggaagca gaagagattc aagggaaaaa ctttaaccat gccacacagg 3337621 atctatatga cgcgattgaa aatggcgatt atccagagtg ggaagtatat gctcaaatca 3337681 tgagcgatga tgagcatcct gaactggact ttgatcctct tgatccaaca aaactgtggt 3337741 ataaagacga tttcccatgg aaaccgatcg gcaaattggt tctgaacaaa aatccggaaa 3337801 actaccatgc ggaagtggag caagcttcat ttggaacggg agtgcttgtc gacgggcttg 3337861 atttttcaga cgacaaattg ctccaggggc gtacgtttgc ctactctgat acgcagcgct 3337921 accgtgtagg cgcaaattac ctgcagcttc cgatcaactc gccgaaaaag catgtcgcca 3337981 ccaaccagga aggcgggcaa atgcaatatc gggtcgatag agcagaagga caaaacccgc 3338041 acgtcaacta cgagccatcc attatgggcg ggctgaagga agcgaagcaa gacggaaaag 3338101 accatacgcc gcatgtcgaa ggtgatgtaa agcgtgaagc gattgacaga acaaacaact 3338161 tcggacaggc tggagaaacg taccggagat ttactgaatt tgagcggaac gaattgatta 3338221 cgaatttggt gaatacgctt tctacgtgcc gaaaagaaat tcaggatcaa atgattgaga 3338281 atttcacaaa agctgatcct gactacggaa aacgcgtagc agaagggcta aaaaaggtct 3338341 ccgaaaacaa cagcaacggg ccgatcggca caactgaaac ggaacaggct gcaaagcagg 3338401 ctgaacagga gagtcatccg tctgatccgt attaacaaca gcgaacaggg cttttttaga 3338461 agccctgttt ttttattttt ctattgaaac gctttcaata attgtgttgt acttggaagg 3338521 aaaggggtgg agagatacga tggaattaca gcaggacttg attcctcaga aaaaaacaat 3338581 cggcgcttta gatcacgccg tttttttatg catggtattt tgtttctggt tttcaggcta 3338641 tatttacgtt cctgtattca gtctgtattt ggaggatctg cacttttcat atggcgcaat 3338701 cggcatcatt ctcggcagct acggggtcac gcaaatcctt ctgcgattcc cgctcggcct 3338761 tttgtcagac atcctgtttt ccttgcgcaa gcaattgtta attgccgggt tcggcttttc 3338821 cgtcctcagc agcctgcttt ttctgatgtt tgattctttc ttcttcgtgc tggccgcccg 3338881 gcttttcgcg ggaatcactg cttctacgtg ggtgatggcg accattttat acgcacatta 3338941 tttcaacaat ggcaatgcat caaaagcaat gggcatcatg cagtttttta ccgtcatgcc 3339001 tcagtttgcc agcattgtgt tctgcgggct cgccgcagcc catttaggga ggcaggttcc 3339061 tttttggatg gcgctggcag cttctgccgc aggtctggtg atctgctgct ttattcagga 3339121 tccgtctgct cctcccgcaa accgtggcac cattcgtgtc aatcagtaca tcaaagatac 3339181 attgcggctg ccaaagctga agcttttcac catcctgtct atgacggccc atgccgtatt 3339241 atttatcaca gtgtttggtt ttacgccgct ttacatgaat cagctcggaa tgggcgacgc 3339301 ggagctgctt tgggtgatga gcgccttttt cctcccacac gcagccgcca cattaagctt 3339361 tgtgtttctg cgctttacaa gccgtatcgc ttactccgtg atgctcatta gtttcgctgt 3339421 caccggggtc tgtttgctat atgttccttt tttagctgca ttgttcacgg tttgcatcac 3339481 acacgcctgt attgggctgg cgctcggctt cgtttttcct ctgctgctaa gccatgtcgt 3339541 cgaaatcagt tctgcccgtt taaaaatgtc agtgatgggg ttttaccaat cattttatgc 3339601 gctaggcatc ttcctcgggc cccttcttgc cggaaaaatc gcacagctta tcgggcttgc 3339661 gggagttttt tatggagccg gttctctggc atttgccgcc ttttttgtga tgctcgcgca 3339721 aaaacgtaac atgatcaatt aatagctttc ataccgccgg aagcgccaca cagaaaacac 3339781 ggccagaagc atgatgcaca gaatggagaa agtgagtgac catccgaaaa aatctgcccg 3339841 ctctccatga agaaggatat gctccgcctg cttgcaaatc tcagccggaa gccacttcgc 3339901 accatctgga aatagtgaaa cagcaaagga aacggctgct gtgagcccga tcccgcaagc 3339961 cgcagctgct ccgacagacc ggaatatcgt acttccggca aggccggcgg tcacaataaa 3340021 tatcacccaa agagcgtaaa ggccaaggct tgcggcaaag cggctgaatg atgcgtcctc 3340081 aaacagcagc cggacgtaat agtaagcaag cccgtatcca gctgcaaacg acataatgcc 3340141 gatcacgctt tggatgagcc atttactcac gatataatgg gctgccgtca caggccgcga 3340201 cataatcagc gctgttaccc cttgatttct ttcattggct acactgccca tcacgctaaa 3340261 gatgaccaga gccatgccaa gcgtgttgaa ttgagaaagc gtgctgacca tcacttcaga 3340321 cccggagggc atcgtaaaac tgattttcat gccgtcagga aggttccctc catgtgcgat 3340381 gatttccggc atataataaa tggtcagcgg ctgtgtcagc ccgacgatca tcatcgcaat 3340441 cggcagccaa atcagcttgc cgcttttcca tccttccagc cactccttct gcaatagcgc 3340501 catcatcacc ttcatgcgtg caccaccttt agatagacgt cttctagaga ctccgttttc 3340561 tgttcaaagc gggtgacggt caatcccttt cggatacagt cacttaataa tgaccggcca 3340621 gcgtgtatat caggcagctc gaaaaccgct tgggacggat tcttatagac aatagctgag 3340681 acgtaaggct tctcttcaag ccaaccttcc agcttctctt tcactgaaag ggtaaaaacg 3340741 ttcgtttgct gctgttgttt cagctcctgt aactcgcctt tccatgaaat ctcaccgttt 3340801 ttcataatca ccacttgatc acacacctgt tctgcatcgt gcaaaacatg tgtagaaaac 3340861 agaacggcca tatgcttttt cagctcccgc atcatgtcca gcacctcgaa ccgtcctgtc 3340921 ggatcaagcg cagacaccgg ttcatccaat atcaaaaact tcggtttatg gagcagtgcc 3340981 tgtgccagac cgagtctttg tttcatgcct cctgaatagc ccccgatcct tttgtgcgcc 3341041 gcttcgtgca aaccgacaaa ttccagcatc tcgccgattt tctcttggca ttttctcttc 3341101 gaaaggccgg acagtctccc cgcaaatgtc aaaaattcat ttgcggtcat ccacgaataa 3341161 aaagcaggat actgcgggag gtacccaatc aaacgccgat ccagcttttt ctctcctaac 3341221 agctttatgg ttccagaggt tggcgaaagc agtccggcca gcatttgcag agtcgtggtt 3341281 ttgccggctc cattaggtcc taatagtgcg acacactcat tttcattcac gtgaaaactg 3341341 acattcttta cagcttcatg gtgcctgtac gatttgcata atgattcaat agacagcata 3341401 tcggcttacc tttgctttct gccgacggtg aaaaataaaa tcggcccgat aatattgata 3341461 catacgatga ttgcagccca catccacttt ggcccgttcg tccgctcttc ttttatacag 3341521 ctgataaggg caaacaccgc caaagccagc tgtaatacaa tcagcggcaa aatcatttcc 3341581 caagaaatat tcattgcttg atcccccttt tcttccgatc cggcctaatg acaaaaaagt 3341641 aataacaaat cagaggcatc ggtgcttgaa tcaatccgac aatcccccaa acccatgcca 3341701 tgtgattacg ttttttcgca tcaataaata aaaagattcc ctgcgccaat acgatgagac 3341761 aagccgcaac cgttatgata atttctgttt gtgtcatccg cgtttcacct cgcattcgcc 3341821 gagatgcctt tttttctcag ccgcaatcaa aatcggcagc accgcaagca cacaaacctg 3341881 aagcacaata aacacagcag gagcttgagt gaaagctaag attgcagcac tcacaaccat 3341941 cagcgcgcag aatacaaata aaatgatctc ttgaagaagt ttttttctgt attcagcttt 3342001 catttgtgac agctggtgaa gcagttcttt ttgattcggt atagagggat tggctgtttg 3342061 atcaattttt ttccattctg actttaaatg atcagaaagc ttttctttat tcatcatccc 3342121 actcctttct gatttgctgg agccctttat gaactctgga ctttacagtg ccttctttga 3342181 tttgaagcat caccccgatt tcagcgtagg tatagccgta gtaatgcctt aataaaaccg 3342241 gtgtgcgcag tttagggtcc agctttgaaa acagatcgag cgtttcgctc cactctgccc 3342301 ctttcgccga cacgtcccac ttgatcttgc ggattgtttc ctccgtaact gtctgattcc 3342361 gtttccattc tctctttctc tttttctggt gatcgagata gagccgcgat gcaatggaga 3342421 tcagccatgt ggagaatttt gaacggccct gaaagcttct taaatggatg taccctttca 3342481 gaaaggtttc ctgaacaagt tcctcgctga gatcggggtg aagggaaagc tttaacaagt 3342541 atttatataa gaaagaatag tgatagtgga aaagggctgt aaacgcctcg tcgtttccct 3342601 ctttcgcctg ctggatcagc cgctgttctt cttgtgtatc caatgaccgt gatcccccct 3342661 tttttgtttt tctgccttat gagacgacac cggattcaaa agcgttcatc ttttttacaa 3342721 ttcttttcag ccattgacag atcaggcttc ccggccgttt ggctgcatat ccttatttgt 3342781 aaaccccctt atagtctgtt aagctatgac tttatgtcga tttcaaaaaa acatccaata 3342841 tggaggacga tgcattgaaa gtagaaaggc gaacgattga atatattccg aatgaagaaa 3342901 gacatggtaa agcgaaagat ttatttcccg tatggttcgg ggctaatatg catatcacca 3342961 cgttagtgac cggcacgatt cccgttgcaa tgggacttaa tctgttttgg agtgttgccg 3343021 ctattatttg cggaacctta atcggtgcca tatttatggc ttctcattcc gcgcaaggcc 3343081 ctcagctagg catcccgcaa atgattcaaa gccgtgccca attcggcgta atcggagcga 3343141 ttcttcccct cttcttagtc atgtttatct accttggttt cttcgcaagc agcacgattc 3343201 tggcggccgg aaccttaagc agctttgttc ccatcccggg atcatggagc attataggct 3343261 taagtgccgt atgtttttta ctcaccattt tcggccatga tttgattcac aaaatgcaaa 3343321 aaatcctttc ttggacctct tttgctgtat tttttgctgc aacgattctc atttttcaat 3343381 tgccgattcc ggcaggcagc tggatacccg gagcgattga tctgccaatt ttcctagtgg 3343441 cagtcagcgc agttgcgacg tggcagcttg cctacgcgcc gtatgttgcc gattattcaa 3343501 gatatctgcc agttaaaaca ccggcttcaa aaacattttg gtacagctat gcaggtacat 3343561 ctgtcagctc catctggatg atgctgctcg gcgcattgct gacaacctca cttcctgact 3343621 ttacggcaaa ctcaggcagc cagattgtcc aattgttcgg tcccttctcg tttattatgc 3343681 tgatcattgt gctatttggg caaatggcaa tcaatgtttt taacctgtat ggggctttca 3343741 tgtccacgac aacaacgctg gagccgtttc tgaaattaaa agtcacgccc aaagtcagaa 3343801 tcatcatgat cctgggtgtc acgcttgtcg gcacagtctt aagcctactg ggacagagca 3343861 attttatgga actgtttttg aattttatct ttttcatcag ttatttctta attccgtgga 3343921 cggcaatcaa tttagtcgat tactacttcg tccgccacgg aaagtatcaa gtcaaagcca 3343981 tgttcgacgt aaacgggcct tatggaaagg tcaattggat caccacaatt gcgttcgttc 3344041 tgtctatctt gctggaaatt ccgtttatca acacaagctt ttacatcgga ccgcttgcca 3344101 aaatgtttgg cggcggagac atcgcatgga ttatcggctt ggccgtgcct tctgtgcttt 3344161 actatgtatt aatgaaaccg cgtctgaaaa aacgggcggg gtatcaagaa aagctgtctt 3344221 ctctctgaag acagcttttt tatcattcaa atcgtttcca cacgcggggc aggatgtcag 3344281 atagctcatg agcgagcaac gtatgagcgg agtgctcgtc cgtccagagc tcggcgcacg 3344341 caccatgcaa atagaccgcg tttaatacgg cgtgctttgg atcttcatgg cagcagagca 3344401 tccccaatat catgcccgtc agcgtgtcac cggttccgcc cttggcgagc gccccgtttc 3344461 cggttggatt gagccagcag tctccatcag gaaacgcgat gacggtttgg tttcctttta 3344521 acacaatgac agtctgcagc tgagccgccc attcctttgc atattccgct ctttttttct 3344581 gcaattcgtt cacgggcacc cctgtcattc ggaaaaactc gcccgggtgc ggcgtgagga 3344641 tgacggggcc ctcccgtttc ggatatgtgc gcttcgccag cgctccggca tccaaaataa 3344701 caggacaatc agccgtaagc acatgatcga ctgcctgctg tacgctttcc gtttgcggaa 3344761 ggcccggtcc gatggcaatg gcccggtacg tctcttcaag ctgagcatcc gccgcctttt 3344821 tccagccgtc acgccaatag gtcgcctcgg gcaaaacagg aacaattagc gggattacgt 3344881 tttctgatgt accgatgaca agcttgccga gaccgctccg catggcccca agccctgcaa 3344941 gcagcgctgc tcccggcatg tcgtcacttc cagccagcag caaagccgta ccgtacgtgc 3345001 ctttatggct ctccgcatct ctttcaggaa gcgtggccct tacatgctct tccgtccaaa 3345061 atggaacatt catctctatc cctcctctgc tttcttttcc tatttttcct gtcccttttc 3345121 tttttcaaac aaaaaagaca gccttttagg gctgtctttt attttacagg aacatcaagg 3345181 tgatacaggc ggcgatatcg ttcgtttgcc gccagcagct cctcatgggt tccttccatt 3345241 tctgttttgc cgttttcgag aaatacgatt ttatcggctg cttccactcc cgcgagatgg 3345301 tgtgtaatcc ataaaatcgt ttttcctttc agcacctcaa acaccgtttc catcaattca 3345361 cgttcggtaa taggatcgag gccgactgtt ggctcatcga ggatgatgat cggtgtatcc 3345421 tgcagcaaaa tcctcgcaag tgcgatccgc tggcgctctc caccggaaaa acggatgccg 3345481 gtttcttgta cagaggtatg atatccgtca ggcaatgact caatgtagtc atgcagcttg 3345541 acctgctttg cggcgcggcg cacatcctcg tcgcttgctt ctccgtttcc gagcctgatg 3345601 ttgttcaaaa tgcttgtatc aaacaggtgc ggtttttgat ttaacacggc caccgcatcc 3345661 gcaatctgat cctttaacag cgctgtctcc actccgttta acgtcacaga accggagtcc 3345721 ggtttcaagg cgccttcgat taatgcaagc gatgttgatt tcccagagcc gcttcggccg 3345781 agcagcgcca ttttttctcc ttggcgcagc gtaaaggaaa agttgtgcag cacttggctg 3345841 ctgttgtcat aagaaaacgt cacatcacga aaggccaagg tgacatcttg aagatcgaga 3345901 atttgatccc ctgattcagt ttgtgacgcc tccggctgag gagccacatt gttcatgcgt 3345961 ctgatagaat cctgatagcc cggcacttcg cctaaggcat ccgaaagcgg caaaaaggct 3346021 tccgtcaacg gaaacaccac tagcacaaaa gcggcaatca tcgttttagc gagctcgccg 3346081 tccgcttgct gtcccgctgt ccaaaacagc atcagcaaaa taaggccagc gacaaggcat 3346141 tgcgcagcaa agtcccgcca tcttgtaaag cgttgttttt tccgttcaag ctcaaaccaa 3346201 tcacgttcct ctttttcata agcatcaata aaagcatgcc ggcgtccgct gaacatccag 3346261 tcgctgacac ccatcacagc atctgtcaga cggctgtaca gcacattccg tccgcttttc 3346321 agcttcgcat tcttcgctct cgtcacgagc aaagacacaa ccggaaacaa tacaacaaga 3346381 acaaacaaat acagcgcaag caatatggca aacggccaag agaagaagcc gagcgctatc 3346441 actgacacag catacaggag caaggctgag atcgcaggaa aaatcgtttt taagaaagca 3346501 tcctgcaaat gctcaatatc ctcagacaaa atgccgagca tatcccccgt gcgaaaacgg 3346561 gaacgcagca tcaaagcacc cggctcaagc atattgtaaa ggcggacgcg catgtcagat 3346621 acgattttca aaatgatgtg atggccgacg agccgttcca catatcgcga cacagagcgc 3346681 gcaatcccaa aggtgcgcac agcgacaatc ggcacataaa tgagcagaat gttttccggc 3346741 cttgtcgccg ctttagaaat caaaaaacct gaggtgaaca tgagaaaagc agcagaaaaa 3346801 atcgtcaccg cacccaaaaa gataaccaga acgaacaggc gggcattttg cttgatatac 3346861 ggcaaaatcc attcttcttt cttcatgctc tttcccccag ttgtgccttc acgagtttgg 3346921 tatacacacc gtttttctcc agcagttcat tgtgagtccc aatttccgca accctgcccc 3346981 cgtcaagcac gataatttcg tccatatcga gcatccagtg aaggcggtga gtcgcgagaa 3347041 agacgagctt atcctcaaat aaatccagca tcgtttcttt tatttcatat tctgtttcga 3347101 tatcaagatg ggcggtcggc tcatccagca gcaggatcgg acggtttccc aaaaaggcgc 3347161 gggccagcgc gacacgctgt gcctggccgc cgctgagcgc ccggccgcct tccccgatcc 3347221 gcccctctaa tccgtcagga aggttgttca ccagctccgt cagtcccgct gaggcagcag 3347281 cacgtgttgt atcctctgcc gaagcgcttg gatggtagaa gcgaatgttg ttgccaagcg 3347341 tatcatcaaa aatgtacgga tgctggggaa tgtaaagaag gttcttctgc cagctgccgt 3347401 cctgcaaatg ggaccggctt gtaccattaa cctcaatcat cccgccatcc ggctctaaaa 3347461 atccgccgag aatatcaatt aatgttgatt ttccggcgcc gcttgcaccg ataatgccga 3347521 tttttttctt gcctttgaat gagagatgaa tatcagacac cgaacggccg actgacacgc 3347581 ctgacagctt cagctcatcc tgatcggacc aagcttcgag ctgaagcggc gtctcttctt 3347641 taaaaccagg ctgcgacaaa atctcttgaa tggtttttcc tgcttcctgg ccgttcagcg 3347701 ttgcatgata atcattcccc acttcccgca ccggcaaaaa atactcaggc gccagaataa 3347761 gcgccgttaa agcagggcca agcaaaatat cgccgtcaat gaggcgcagg cccagaaata 3347821 ctgcgactgt cgccaccgac agcatcgtga aaaaatcgag ggcgaatgat gacaaaaacg 3347881 ccacccggag tgtgctcatc gttgccttgc gataccgctc actcacatag aaaatatttt 3347941 tgctgtgtga cttgctcaaa cctaggaaac gcaatgtctc cagcccgcga agagaatcaa 3348001 caaaatgatt ggaaagtctc tgataggatt tccactgacg atccgctttt ctctgcgcga 3348061 caaggccgag gagaatcata aagatgatca gaatcggcat agcagcgact aaaatgatgg 3348121 ctgatgtccg atcctgaaaa aacacataaa tgacaactgc cgcaggcaca atcgccatgc 3348181 tgaccatttt cggcagaaac agctccaggt agcggcggaa ctggctgatg ccttccatcg 3348241 ccagcgtcac catttgcccc gtcccctctt tctttgcaaa gcgggggcct aatcggaaca 3348301 gctgatcaag aaaacttttc ctcaaatctg ctcctgtccg ggcggcgtat tgatagacga 3348361 ttttctgtcg cgccaccgtc atcccgtgcc gggcgataaa agcgatgagg aaaaagccga 3348421 tcaccggtaa aagggaggta atgcccttcc cgttgaacag tccggttacg gcctcactca 3348481 gccactctgc ctgcataata atggcggctg tctgaatcaa cgttaaacaa gtaatcaagg 3348541 tgagaatccg cttcattcct ttatatcgaa acaggtcttt tcccattaat aagtcatagg 3348601 ctccttatgg ctgacgcgct tccggaagac ataatagctc cagatctggc tgccgatgac 3348661 gaacggcaat agcgttaatg ctgcaattga catgacttta agcgaataat ctccagaaga 3348721 agcgttagct actgttaaat cgtatgcgct atgaagcgag ctgaccatta cacgagggaa 3348781 tagggaaata aagatcattc ccacggtcag cgccagacca gcgcctgtca tcccaaatgt 3348841 ccagccgtct tttttcttac gaataaatac agccgcgagc ataaagcaga tgacaatcaa 3348901 aacagcgagc ggaatggtaa tctcgccgcg gcgtgtaaac atgtctgtct gatacgcaga 3348961 aagggccgcg aaggcaagaa ccgctacaaa aacaacaccc attatctttt gcgccatttt 3349021 ccgggcgcgg ttttgcaaat caccaatcgt acgcagcgtg ataaacatta atccatgctg 3349081 gaagcaaaga agcgttaccg tcacaccgcc aagtatagaa tatacattga tataatcaga 3349141 tacatgtgcg tgaatgttca tgtcggcatc aatcggcatc ccgcggaata atgtcgtgaa 3349201 cagcacacca agcacaaacg gaggaattag actgccgaaa aaaacgaccc agtcccaaac 3349261 ctttacccat tttaaatgat ccaccttgcc gcggaactca aacgcgaccc cgcggcccat 3349321 taacgcaagc agcactatga caaacggaat gtaataaccg ctcagcatcg ttgcatacca 3349381 gtttgggaat gccgcgaaaa tggcgcctgc gccagtcaaa agccacactt cattcgcgtc 3349441 ccagaacggc ccgatcgtgt tgatcagcac tctgcgttct aattcattat ggccaagaaa 3349501 acgggtcgcc atgccgaccc cgaaatcaaa gccttccaaa aagaagaatc ctacaaacaa 3349561 tacagcaacg agtataaacc aaagatcatg aagagatgcc atggtatacc tcctgactaa 3349621 atggatctgt tgatacaggc acatcatgat gattatcatg ctccgcacct tttttaatct 3349681 cacggataaa caagaagaca agcagtgcac caagaatcat gtacatcaca ccgaatgcga 3349741 tgattgagaa taacaaggaa cccgctgtta cgttaggcga cacagattga gcggttgtca 3349801 ttaaccccat aaccgtccaa ggctgacgtc cgatttctgt cataatccag cccgcggagt 3349861 ttgcaagaaa cgggaaggaa atcaacgcga tcatgatgcg caaataccat ttgctgtttt 3349921 caagcttttt acggcggttt aaccaaaggc cgcctaacgc agcaagaatc atgacaacac 3349981 ctgctcctac catgatgcgg aagctccaga atgtcgtttt cactggcgga atgtagtcgc 3350041 cttttccgta tattttttcg tactcagcct gaagggtttt catccctttg acacttccgc 3350101 tgaatttctg ataagccaag tagctcaagg cataaggaac tttgatttca tttgagcttt 3350161 tttcattttt tgtatcgatc gtcgcaaaag cggtccaagc agcagggtca ccgctgtctt 3350221 cccataggcc ttcactggca gccattttca tcggctgtga ttccatcaag tgctcagcct 3350281 gcatgtgtcc gctaaggccg acgccaagac cggcacaaag accgacgatc attgcgagtt 3350341 taaaagattg cttaaagaac ggcacttctt ttttcttcag cagtttaaaa gcactcactc 3350401 cggcaataaa gaaagctcca gtggcaagcg caccgaaaat aacgtgcggg aattcaaccc 3350461 aaagctgagg gtttgtaatc aacgcgccaa aatcattcat ttccgcgcgg ccgtttttga 3350521 tcgtaaagcc gaccggctcc tgcataaagg agtttgctgt taaaatccag aaagatgaca 3350581 tgatcgttcc gaatgatacg agccatatgc agagcgcgtg aattttcttc ggcaggcggt 3350641 cccagccaaa aatccataat ccgataaaaa tagattccat gaaaaacgcc aataatgctt 3350701 caatcgcaag cggagcgcca aatacatctc cgacaaaacg ggagtaatct gaccagttca 3350761 gtccaaactg gaattcttgc aaaatccccg ttacaacacc gactgcgaaa tttattaaga 3350821 ataagtgtcc ccaaaacttt gccattttga gatacagctc atttttcttt acaagataaa 3350881 gagtctccat caacgcaacc ataaacacaa gcccgataga catcggcaca aacaagaagt 3350941 gaaacaacgt tgttgatgca aattgtatgc gggctaatac caattcactc atgctttctc 3351001 ctccatttcc ggttaaaact gttaatttgc tcactacttc acaaatagaa ccgagacttt 3351061 gatcagtaat tcacaaaata gacgaaaaaa atattgctca atatttcaca aatgtgtcaa 3351121 aaagtcatcc aatatgatgc aagattgcca gactgaccaa atgacacaat ctctgactgg 3351181 ttcatattaa gtactttaca acgattcatt tcaaaaataa agcctaaaat acctaaaaag 3351241 tcccgcacta tgtgacggat ttttgtctat tttgttgctt atttatgtcg gctgctagga 3351301 taaatgaccc tttattatcg tacatcaaca catcgttcct tgcgaacaaa atgcttgccc 3351361 ccgccccagc actcgagtct cagcattccg tcttaaaccg attttagtca gaatgcctct 3351421 tttcatttga accggtaaga ggagaaaagt tgaatagtaa atttttaata tattaataat 3351481 ttcaattttt tagtatactt aacatagtga acaatttcac tgcatcaaga ataggggagg 3351541 tttttcaatg ggagagcttc aaacacacat gcaattgcaa acggatacaa ttcacgaagg 3351601 ggttcgaaaa gagaattggt ttgcgaaagc catgaatata aaagtaggca tcataccgct 3351661 tcctgtgtat gccttgctgt ttatattaat cactgttttt gttatgcatc acgatgtaaa 3351721 aagtgacatt ttgacatcca ttgccgtcat ggcgtttttc gggtttacct ttgcccaaat 3351781 cggcaaatcg ataccgattg ttcgttctat cggcggcccg gccatcctag ctacttttat 3351841 tccgtccgct gtcgtgtact atcacctgct gcctaatgat atcgtcaaat ccaccacaga 3351901 atttacagaa aactcaaact ttctatattt gtttatcgcc ggtattgtcg tcggaagcat 3351961 tctcggcatg aaaagagaaa cactcgtaaa agcattcatg aaaatcttta ttccgcttat 3352021 tgtcggttct gtcacagccg ctattgtcgg actggctgtc gggacattgc tcggactcgg 3352081 atttcagcat accctgctgt acattgtcat tccgatcatg gctggaggag tcggagaagg 3352141 cgctatcccg ctgtccatcg gatattctga catcatgccc atttctcaag gggaagcgtt 3352201 tgcacttgtt ctgccatcga ttatgctggg cagcttgtgc gcgattattc tagcgggatt 3352261 gctgaaccga atcggaaaga aaaaaccgga atggacaggc aacggcaaag tggaccgctc 3352321 cgaagaagag tcccctgcgc tggaggaatc tcaaagcgga cagcaaatgt tcaacctttc 3352381 tttatttgcg tcaggcggta tccttgctgt ttctttatac ttagtcggca tgctcgctca 3352441 cgattttttc ggttttccgg cacccgttgc catgctgtta ctggctgttc taatcaagct 3352501 gttcagattg gtgcctgcct caattgaaaa tggcgcgttt ggagtgtccc gcttcttttc 3352561 aacagctgtg acctacccgc ttctctttgc gattggggta tccatgacgc cgtgggacaa 3352621 gcttgtcgcc gcttttaacc tcagcaatat tatcacgatt ctgtctgtcg ttgtgaccat 3352681 gatggccgtt ggcttcttca ctggaaaatg gctgaacatg tatccgattg aaaccgccat 3352741 tattaatgca tgccattctg ggcaaggcgg cacgggtgac gttgccattt taagcgccgc 3352801 tgaaaggctt gagctaatgc ctttcgccca ggtgtctacc cgcatcgggg gcgcgattac 3352861 agtatcctta accttattgc tgctgcacca gttttattga tccccgcaag caagttcttc 3352921 gtcaaacgaa agagcttgct tttttgcatg tccatgtttt tgcaagttcc catcccatgc 3352981 tatagtaata gttggaaata ctagatagaa aggaatctgg catgcctatg ggaactcatc 3353041 tatttctctt tatgcttctc gggctgggat tttatttgat atcagcccta gctgcaaaac 3353101 tcattccggc catagacttc tggattgata ttgttctatg ggtcggcgct gcggcttaca 3353161 tcttctctca tctctcattc atggacggca ttgtctcact cgcgacaatg ttctactgct 3353221 attggaccgc aatggatctc attgtttcag agcgtgtgga aaaaccttcg ggagactggc 3353281 aggaaatcga gcttgccaaa aacaaaacac gcctcctgtc agacattacg ctgaccgcca 3353341 ttgtgtttgc aggggctgtc atttttttca tctatggacc tgacacaagc cctctcaaat 3353401 atgtgatcct tctcggaatg atctccggcg gaggggcact tgtgaagcga atactgaatg 3353461 tttttagcgt aaaggttttt tattcagcag ccttagaaaa attgcatatc agctcacact 3353521 atgaaacccg tacatacccg ctttccgatt tgaagaacat tcagcttgaa tcaacagcag 3353581 atctcttaaa gctccatccg cttctgacga tgtattcatc ccgtttagat ttgacaacaa 3353641 gctttcagca agtcattaaa ctgtctcttc ccggcgaaac actgtttctg acggtgaagg 3353701 aaccgcaaaa atggaaaaca attcttcagg aatacacaga tgcagaaaac aatgtggaca 3353761 atgtgatttc tgttttgccg ttttatcatc gaaaaaatgt gaagcggctg ctcggtaagc 3353821 tttattttgc cgccagcgta aaaggggtat ccgcttacgc cttattggtg ctcgcgttat 3353881 acgcattaca cgcctctcca tgggtcatgg ctgttgccgt aatcctatat tgggtattca 3353941 acatgtatat gtcagaccgt gtgttgcggg cggcgatgga cgccaagtct tgtcatcatc 3354001 cgcatgtaca ggccgcggcc gataagattt tcagatcggc cggcatttcc catgtccgca 3354061 tatacgaaac ggagagtgat gattacaacg gaatggcagt aggcatgaat gtcgggaggt 3354121 caatggtcat cctgacaagc gccacactaa cacttccaca gcgtgtcatt gaaggcattc 3354181 tggcccatga ggcgattcat atcaaaaaac gtgacgttct gtcatcacag cttttgcgtt 3354241 ttctatatct tggagctgtc gtggggattt tcctcttgtt tgagcagcat atcacccatc 3354301 ccgaggccca caaaattgcg ctttgggctt tcattatggc aatcattatc ctattccagc 3354361 tctatcaatc cttttgttca caatggatgg aggtgcgtgc tgacaacctt ggcgcatcat 3354421 tgctggacgg cggttacaaa caaatggctg aagccttgag aatcttggcg gttcggcaag 3354481 atgaggatat acagaaacaa agtgcctata gctctgaagc aggtgaagac gagcttcaaa 3354541 ttgattctct cacccgtgat aaaagctggt ttttcagatt gattgatttt cagttcgctc 3354601 ctcatcctcc tatgtattgg cgtgtcggca ctttattgtc aaacaaagga catggggtgc 3354661 taaagcgctg gctcagagac cgactgaaag aatcgatcac tttgaaatga aaccggtcag 3354721 cgtttcatcc gtataacaga tatggtgaaa aaagggagtg acgcgaagtg attgtgatca 3354781 tcttattgtt tatatctatt attgtttttc tttcagtcat tcagccgcag ccctcgaaaa 3354841 acaaaagccg ccagcaggcg gacagcgggt atttcggtta ttcagatcat agctcacacc 3354901 atgatggatg cagcagtgac ggaggtttca gcgattccgg ctgtggcggc ggagggggcg 3354961 gcgattaaac gccgcctttt tttatttcat tgattcgatg tacgcaccaa aagccgagcc 3355021 tgacatgcct ggggacacgc gcacacgatg gagggcatac attccctggt ctctcgaagc 3355081 cgcgcccggt tctgtcgtca cgcccatttg atagcctgtt ttttcagcgg ccttcagcgt 3355141 ctcctcattg tagcgcccta ccggatagct gatgatggtg gtttgctgat gaaacatgtt 3355201 gtcgaacagc tttttcgaat cagccatctc actttgctgc tgttgaggcg ttaatccgtt 3355261 cagctcaagg tggtcaatcg tatggctttc aatcgatatg ccgtgctgtg ccatttcctt 3355321 catttgttcc tctgtcagat ggtgcttatg tccgatcgat ttgccgatca taaaaatcgt 3355381 tgccttcatc ccgtactttt tcagcaccgg atacgcatct tgataattgt cggtgtaccc 3355441 gtcatcaaat gtgatcagca cgcacttctc actcggtttt ttatcctgcg tcagcatgag 3355501 agatgcctct ttcggcgtta atgtctgata gccgttatca tgaagccact tcatatgcgc 3355561 ctcgaattct ttctttggca cacggaggct gtttcctgaa gaaatgctgt ggtacatcaa 3355621 aatcggcagc tttgccggtt tctctgtttt gatccatgcg gatgtatcgt cttctttttt 3355681 ctgaacttgt actgcctttt tttccggttt cttttgttcc gcttttggca tcggctgctc 3355741 tgcattcgcc tcttgatcag cacaagccgc aagagccaaa cagctgccca aaagaaagat 3355801 gcttaaaaac aatcgtttca tcgttctcct gctttctgtc tatttcttcc tcctttttca 3355861 tcggtttgat tctgagattt tcaatagcaa aaaaccggac atgtctccat gtccggtttt 3355921 tttgatctta tcggattctc acttctgtct cactgtcaaa gaaatggcct ttattcatat 3355981 caaatgcaac cgtcagctca tcgcccgatt gaatatcgag gcgggcgtcg atccgcgcaa 3356041 taaagtcttg gttgtctatc tgcgaataaa tcataatttc agaaccgagc agctctgcaa 3356101 cattaatttt cgccttaatc gaagagttct tatatgattc cacgacaatc aattcatcat 3356161 gtatatcctc aggacggatg ccgaagatga cctctttgcc gatgtagcct ttttcacgca 3356221 gcactttcat ttttccttcc gggacggtta atgccgcaga accgattttg attaagccat 3356281 ccgtgagctt tcctttgaaa aaattcatcg ccggtgatcc gataaacccg ccgacaaaga 3356341 cgttttcagg gaattcatat acatccttcg gcgtcccgat ctgctgaatt ttcccatctt 3356401 tcatgactac aatccgtgtc gccattgtca gcgcttctgt ctggtcatgc gtcacataaa 3356461 tcgttgtagt ctgcaatctc tggtggagct taatgatttc cgcccgcatt tgcaccctca 3356521 gcttcgcgtc caggtttgac aaaggctcat ccatcaggaa cacctttgca tcccgcacga 3356581 ttgcccggcc cagcgcaacc cgctgtctct gtccgcctga cagcgctttc ggtttacggt 3356641 gcaaatattc ctcaagcccg agaattttag cggcttcttc gactcttttt ttgatttcag 3356701 gcttcggcat tttccgaagc ttgagcccga acgcgatatt atcgtagacc gtcatatgcg 3356761 gataaagcgc gtagttctga aataccatcg cgatatccct gtcctttggc gctacatcat 3356821 tgacccgttt tccttcaata taaaaatcac ctttcgaaat ttcttcaagt cctgcgacca 3356881 ttcgcagcgt cgttgatttc ccgcagccgg acgggccgac gaatacgata aattccttat 3356941 cggcaatatg aaggttaaag tcatcaaccg ccggttcctt ctgatcataa aatttataaa 3357001 tgtgctccat ccgcaattca gccatctaac atcccccttt gttattgtaa acgctttctt 3357061 atattgagtg taacagcaat tccctctcgc taaaatgggc agcgttcata aaatcaccca 3357121 gccatttttc gtgcatattt ccaatttatt ctgaactttc attttgcagg cagataaaat 3357181 aggcaagaag cgcgcctttg tacgatttga tatctatccc tgaccgctca ataaatttat 3357241 caatccgata ttgcaggctg ttgcgatgca gatgcagctt tttcgctgtt aatgtgacgt 3357301 ttgagttgtt ttcaataaac agcttaatgg tcttccttag ctcagattca cttccaaata 3357361 aaagctcagc ttcttcagag agcagtgttt ccagtttttc tttttctgtt tctaataata 3357421 gaaaaggaaa gatcatctca aaggtcacac tctgcacctg aggcagccgt ttttcagcaa 3357481 acaggaaata cgcctgttca cgagcgtaat gttttcgcag acactcatcc ggctcgtaaa 3357541 atcttccggc gtaaaaacgg acactgaagt agaaatcact ttcaagaacc ttagcgagcg 3357601 attccagttc gtccttctcc gccgccgctt cactttcctg ctcgacaatc acacctctgt 3357661 cctcatggat ccacacaatc acaaaagaca ccggccaaaa atggcgaacc gcttccgtaa 3357721 aggacgtcct ttctattttg ccgaataaat gaaagtgaac aaatctcgtc cgtttcttta 3357781 tatacgccgg caattcccct ctggaaaaaa ggaacgaaaa ccacttgttt tcctcaggtg 3357841 atttcataga cagttgattg ccctcatccg caggcgtcaa aaatgactgc agcaccaata 3357901 cttctttttc actgatctct gttttcggaa tggagatata tctctgattg ctctcatcaa 3357961 aaaaacatag acagccttcc cttatgcaaa gctcctcaga cacaatcgaa ccgggataaa 3358021 tagccagcag cgatttcata gagtctcctc tcttatgtaa ggatctgtat attcagtata 3358081 aggcgaaaca cacatgttct ccactaaaaa agagtatatc cggtatagat agacgagaaa 3358141 ctgaaaggga aacctcattc gtttacatat tggcttcagc ggaaatagaa gaagacatgc 3358201 aggaccaaag gagggtcatc ttatgagttt cgaaacgtta aacaaaagtt ttatcaacgg 3358261 aaaatggact gggggagaaa gcggacgtac ggaggacatt ttgaatccgt atgaccagtc 3358321 tgtgatcaca acagcatctt tggcaacggg caaacagctt gaggatgcgt ttgacattgc 3358381 acagaaagcc caaaaagagt gggccaagag cacgacggaa gaccgaaaag ccgtgctgca 3358441 aaaagcgcgc ggctatttac acgaaaaccg tgatgacatc attatgatga tcgcccgcga 3358501 aactggcgga acgatcatta aatcaacaat cgagctggaa caaacgattg cgattttaga 3358561 tgaagccatg acgtatactg gtgaattagg cggcgtcaaa gaggtgccat ccgacattga 3358621 agggaaaacc aataagattt accgccttcc gctaggtgtc atttcatcga tttctccatt 3358681 taatttccca atgaatctat ccatgagatc cattgcgccc gcaattgcgc tgggtaacag 3358741 cgttgttcac aagcctgata tccaaactgc tatttccggc gggaccatca ttgcgaaagc 3358801 gtttgaacac gccggtcttc ctgccggtgt ccttaacgtc atgctgacgg atgtaaagga 3358861 aatcggggac ggcatgctca ccaatccaat cccgagatta atcagcttta cagggtcaac 3358921 agcagtcggg cgccacatcg gtgaaatcgc cggtcgcgcc ttcaaacgaa tggcacttga 3358981 gctcggcggc aacaatccat ttgccgttct ttcagatgcg gatgtcgatc gtgctgtgga 3359041 tgccgcgatt ttcggaaaat ttattcacca gggacaaatc tgtatgatta tcaacaggat 3359101 catcgttcat caagatgtat acgatgagtt tgtagaaaaa ttcaccgccc gtgtcaaaca 3359161 gcttccgtac ggcgatcaaa ccgatccgaa aaccgttgtc ggcccgctga tcaacgagcg 3359221 ccaaatcgag aaagcgctgg agatcattga gcaggcaaag acagacggca ttgagcttgc 3359281 ggttgaagga aaacgcgtcg gaaacgtgct gacgccgtac gtctttgtcg gtgcggacaa 3359341 caacagcaaa attgcccaaa cggagctgtt tgccccaatc gcaaccatta ttaaagctgg 3359401 cagcgaccag gaagcgattg acatggcaaa tgatactgaa tacggcctca gctctgcggt 3359461 tttcacttct gatttagaaa aaggcgaaaa gttcgccctg caaattgaca gcggcatgac 3359521 ccatgtcaac gaccagtccg tcaatgattc gccgaatatt gcctttggcg gaaacaaagc 3359581 aagcggtgtc ggccgtttcg gcaatccgtg ggtcgtcgag gaatttaccg tgacgaaatg 3359641 gatttcgata cagaagcaat accgcaaata tccgttctaa atgaaaaaat ccctctgttt 3359701 caagtacaga gggatttttc tttatttaga tatatccaca aacccttcgc caaacacatc 3359761 gcgtacgtca tgtacgatca caaacgcttt tttgtcgcag cttctaatga tttttttcag 3359821 catagacagc tcctgtttgt taatgacgat atacaaaatc tcttttgact ggcccgtata 3359881 atttcccttc cctgataaaa tcgtcacgcc ccgatccatc aaggtattta cctgctctgc 3359941 aatctcactc ttattttctg aaatgaccgt aatggctttt ttcgtattca aaccttcaat 3360001 aatgaagtcc atcactttgg taccgatata cagcatcacg atcgtaaaca tcattttttc 3360061 tgcaccaata ataaaataag agctaaatac tacgattaaa tcaaaaaaca agagtgcata 3360121 gctgatattc cagtctaaat atttattagc aattctggcc agaatcgcgg aaccggccgt 3360181 cgtcccgccg acccggataa tcatgccgat cccgactccg gcaaatacac ctgcgaaaat 3360241 cgtattaatg atcaattcat cagacggaat gctccaccca tgtgtcagat gaagaaaaag 3360301 cgaatttgcc gcaaccgcaa tgatcgtata aaccgttgtt tttccatcaa gaaacttgta 3360361 gccgattaaa agcaaaaacg catttaagat aaagttcgtg acaccaggag accattgaaa 3360421 cagataatac aaaatcagcg taatcccagt gactccgcct tccccaagat cattgggaat 3360481 cgcaaataaa ttaaccgcaa gcgcgaagaa aaaagcgcca atcacaagca taagtacatc 3360541 cagcattctc tttttcatca cgaaaacact ccttttcatt gttctgttct agcaaataaa 3360601 aaaacccagg agaacgctct cgaaaaagag cagaaactcc tgggctttta tcccaccgtg 3360661 tcataacagc caagctgcta tgtgttttct ctcggtcaca gtccaatttg cattgcggaa 3360721 ccctagaaaa ccactgtttt tatcatatcc ttttcacttt ccaatattag cattataagg 3360781 gacggttcga attggttcaa ggggtatttg cggagttttc atcagataag ctggaaaaaa 3360841 atacgattta tctattaaaa aagaacagat ataaccgata agaaaaaaag catatatttt 3360901 acaagcgaat gtaactataa atgataataa ttataagaaa ttcataattt tatattgact 3360961 aagagaaata atataggcat tatagtacat atgtttcgta cattttatta cataggagga 3361021 aatataatgg caggaaaact agtaccctgt aaagcttgcg gtcaagaaat tgcaaagggt 3361081 gtaaaaaaat gtcctaactg cggtaaggat caacgtaact tttttatgcg acataaaatc 3361141 attacgttta ttctcgcagt tgttgtcatc attattatcg gtaatatgat tggcggcgga 3361201 ggcggctcag aagccacttc caaaacatca agcagcagca aagcagaaac tgaaaaaaca 3361261 tacaatatcg gtgataccgt aaaaactgaa aaaactgaag tgacggttac gaaggtagag 3361321 gacagagata ctgtcggtac tcaatatgtt gaaaagaaag catctgaggg aggtacaatt 3361381 gtagctgttc aatatacaat taaaaacgta tctaaaaagc cgattagctc tttttcaatt 3361441 ccaactgtta aattagttga tgctgatggt acttcttatg attctgatat tgatgcttct 3361501 gtaaactatg caactgagac aaaagttgat aactctaaaa ttttgagtga tctaaatcct 3361561 aatattaaag taacaggtgt aaaagcattt gaagttgaca aggaagctta tgcaaaaggc 3361621 acttggaaac taaaattcag taatgatgtt attgtgaaaa tcaaataaca gctaacaagg 3361681 gtgcctgttt aggcaccctt gttctttaaa aaaggccttc tcaattgaga aggcctccat 3361741 tcttattccg cactcttata cccattcaca ttagaagact gccatctcca ggaatcagca 3361801 cacatttcct caaggccgcg tttcgcttcc cagcctagtt ctcgcttggc tttcgcagga 3361861 tctgcaaagc atgtggcgat gtctcccgga cggcggtccg caaaacggta tggaacctct 3361921 ttccctgaca ctttttcaaa ggctttgacc atttccagca cgctgtagcc tgtgcctgtt 3361981 ccaaggttgt atgcatcggc tcctgtagag ttcaatactt tttccagcgc cttgacgtgg 3362041 ccttctgcga gatcaacgac gtgaatataa tcgcgtacgc ctgtcccgtc ttttgtcgga 3362101 tagtcatttc cgaatacgct taattgctcg agcttcccga ctgctacctg tgccacatac 3362161 ggcataaggt tatttgggat tccgttcggg tcttcaccga tccgtccgct tggatgcgcg 3362221 ccgaacgggt taaagtaacg aagcagcgca acgctccact cattgtcggc tgtatgcaaa 3362281 tcacgcaata tttgttcaag catgagcttc gtctgcccat aaggatttgt cgcgcctaat 3362341 ggaaagtctt ccgtaatcgg cgatgtttcc ggaacgccgt atactgtcgc agatgaactg 3362401 aatacgattt tcttgacgcc gtatttctcc atggcctcgc ataaaataaa cgttcctgtc 3362461 aaattgttat gataatattt gaggggaatc gccacagatt cgccgactgc ttttaaccct 3362521 gcaaaatgaa tcacagcttc gatttcattt tcagcaaaaa cggaatctac cgcttcccgg 3362581 tccaataaat ccgcttcgta gaacgttaaa tcttttcctg taatctcctt gacacggttc 3362641 agcgcttcag ctgaactgtt ggacagatta tcaagaacaa caatctcgta gccgctgttc 3362701 aatagttcaa cacatgtgtg gctgccaatg taaccggcac cgccagtaac aagtattgcc 3362761 atgatgtaaa ccctcctaaa aaatgacctg ttttcattat atagtgttta gaaccggtcc 3362821 acatccattt ttaagaagtt taatcgttta ttaatagttt tttcatattt tttagcttaa 3362881 acccttgcca gcaattcgat agaggtttca gcaagaatgt gctctttcat ttcttgatag 3362941 agctcattca agtaaaagcc cggctgaaga ttcagctcag catctaaagc atagaccgtc 3363001 aatgtatacg catgatcctt gtcaggcggt gtcggcccgc aatactggtg aatcaccttt 3363061 ggatcgttgc ttcccgcaag cggtgaagca aagctgtttt gcccttgtat catcaagtcc 3363121 tgtctttcct cactcgcatg ttcaggaagc tctccgatgt aagccggaat attagccgct 3363181 gtccagtgaa tccagctgaa tccgcatacg ggaatggcgt catgatcgat gaaagtaagt 3363241 gcgagcgtct ttgctccgga cgggatgtca tcaaaatgaa ttggaaagga tacaaatggg 3363301 tttccttctc tcttatattt ttcatccgcg tattttgaat acttgtcatg taaatatgga 3363361 tttgcttcta cgtatatgtt catatgaatc cctctctcta ttttctcgtt ctataggtat 3363421 actaaacgaa tcgatgtata atcagtgata aacaaatacg catgtaaacg taacaatttg 3363481 ttatggataa cttgcagtga aggagatatt tcatggattt aaaatggctg caaaccttta 3363541 ttgccgcagc ggaatcagag agcttcaggg aggcggctga gcatctgtat ctcacacagc 3363601 ctgccgtttc tcagcatatg aggaaattgg aagatgaact ggacatgagg ttgtttttgc 3363661 atagcggaag acgagtcgta ctgactgacg aaggcaggct ctttttgcct tatgccaaag 3363721 aaatgatcca tgtttaccaa gctggaaagc agaaagtcag tcaatggaaa caggggtaca 3363781 gccgatcact cacgctggcc gtacacccct acattgcgtc ctatatcttg cctcgctttc 3363841 tgccagccta tatccaaaaa catccgcatg tcgagctttc aactcatgtg gctggatctg 3363901 acgctattaa acaagcggtg gaacacaatg aagctgatat tggtttgtcg cggaaagacc 3363961 cgaacaccaa cactctttat tatcagcata tatgcgaagg tacgctttgt ctggcggctc 3364021 ctttccaaga aagcagaccg gatgctgcat ccgtcttaac ccgctatcgg ctgctaacgc 3364081 atgatcatcc gtcatatggg gatgcctttt tagataacat ccgatcacat tacccgtatc 3364141 ttcaaatgat ggctgtcggg cagacggata cggctgtcca catgatgaaa gcgggaatgg 3364201 gggcatcttt cctccctacc tacattatca aacaggaaga agccgaaaaa aagctgatgg 3364261 ctgtcagcac gcctgcacat ctagaattgc ctgcgtccca aacgtttatg atgtggaaaa 3364321 gaaacagcga agacattcag cattttcacg ccatgttaca tgactttatg cagcgcgaac 3364381 aagtatagag ctgaaaaatc aatctgccgg ttgacgtttt tctttcctat tttcgctatg 3364441 cttaatgcag aaaggatttg atgacatggc gatgagccct tatattttta ttgtattgat 3364501 tcttattatt ttatcgatgt atcgagaaag aacggtaaag cccgggaagt tgctgatcat 3364561 tccactgttg ctcttatggg gcgtatctgc atcgtttcag ccggcgtatt ttcattccgt 3364621 attacatgtg gcgatcagcg gcattttatt actgatcggg ctggcctgcg ggtttggcat 3364681 tgggaagatg gtaaatgtac ggattcaccc ggaaaccgga aaggtcactt cacgcggctc 3364741 acttgggagt gttatcctca ttctagtgat actttctttg cgcatggccg cgagaacatg 3364801 gctgcctgag agcaacgaga tgtttattgc cattattcat tctatgttct tcgttcccct 3364861 cggcaccatc acagcccgca acatcatgct ttacaaagca tacagacgac tgaccgctgg 3364921 caaagtatcc attcaataac cgaaagaagg accagcatga acggacaaac tccggctcgg 3364981 cactactaca agaagcttgt gccgagcctt attctcattt tgaattgcat acaattttta 3365041 tctcatccaa ctaaggctga tcccattttg ttagcatttg tatttgcggt atacttagca 3365101 ttcatttgga tcattcccta tgtggcatcc actgctgtta gtttgagcat attcatcgga 3365161 ctctggctcc tgaccgattt cttttgggct gtttccggcc aagagcaggg tgccgcctat 3365221 tttttgattg tatttttaat gatatatgcc gcctttagac tcccttcacg gctatccttg 3365281 atcttcacag catgtttaat tggaggcaac atattactcc tatcctcaca agggggaagc 3365341 ttgaatacca tcatcagcaa catctcgatc atgctcggtc tgtacgtcct cttctcctcc 3365401 atgcgtttca gacgagaagc gagaagggag gctgaacgga atcatgctga attggcaaaa 3365461 atgcatgtgc agctggagca tgctcataaa gaactccaga aagcgcatgc agagctgcag 3365521 gaggcttctg ttctttcatt aaggtacgcg gtccttgagg aacgtacaag aattgcccgc 3365581 gacattcatg acagcatcgg tcacgagctg acttctgtga ttgttcagct tcaatccctt 3365641 ccctatatcc ttaaaagcag caaggaggat tcagaaaaag tcattcaaaa tgtactgagt 3365701 gtcgccaggg agtgtcttca agaagtgcgg tctgttgttc accaaatggg ccgtagtgaa 3365761 tcgatggtgg ggcttaccgc tttgcggggg ctcattcatc aagtggagga acggagcggc 3365821 ttgcacgttt ctttagatac tgccggactg tcagaagagt cttggcctcc aaacgtgagc 3365881 gaaacgatct accgcatctt gcaggaagcg ctgaccaata tcattcgtca cgctgacgct 3365941 tctcatgcgg cggccgtcat ttctaatgac aagtcccatc tctatgtcac aatcaccgac 3366001 gacggacaat tcaccggcag ccttacttat ggatttggcc tgacaggaat gaaagagcgc 3366061 gcagaaaaag caggcggttc ccttactttc agtgccgtac agccgagcgg cctgaaaatt 3366121 gagctgtcat tgccgctcat gacaacgaat aaggagcaaa aagatgaaca aagataaaat 3366181 acgcgtagcg cttgccgatg atcagccgct tgtgcgtgaa ggcttccgct acgtcatcaa 3366241 cgcacagacg gatatgacgg tttctggcga ggccggcgac ggtcacgata ttatagcact 3366301 cgcaaaacaa acaaaacccg atgtcatcct catggatgtc cagatgccgc gttgctcagg 3366361 catcgaagcg gcgaaagaca ttatgtccgc acttccaaat acaaagatag tcattttaac 3366421 cacctttgac acggaagaat acgtatttga aggcatccgt gcgggcgcag tcggctatct 3366481 gctgaaggat acacttcctg aggagttgat agatgcgatt cgcgctgcgg ccagaggcga 3366541 ggcgattttc cgtacagtca cagctgctaa aatcatcagt gagacatttc gggcgaaaca 3366601 gcaaactcat gccgaagaac tggcagagcc gttcaccaaa agagagcttg aggttcttca 3366661 gcaaatggcc tacggactga gaaatgagga tattgctgaa aagcttttcg tcagtgaaag 3366721 cactgtgaaa acccacgtgc accgcatcct gcaaaaatgc aatgcccaag accggacaca 3366781 ggcagtcgtt tttgccattc gaaacggtat tgtgcaatag aaatctctca tcccgccatg 3366841 ctaaaataag acaaaggaga tgattggaaa tgaaagaaga aatcattgaa cggtttacta 3366901 catatgtaaa agtcgataca cagtccgatg aatccgttga cacttgtcct tccacacccg 3366961 gccaattgac attaggaaac atgctagttg atgaattgaa gtccatcggc atgcaggatg 3367021 cagccattga tgaaaacggc tatgtcatgg caactcttcc ctccaatact gaaaaagacg 3367081 tgccgacaat cggctttctc gctcacgtcg acaccgctac agactttacc ggcaaaaatg 3367141 tgaatccgca aatcatcgaa agctatgatg gaaaagacat cgttcttaac gaacagctgc 3367201 aggtcaccct gtcacctgat caattccctg agctgtccgg ctataagggc catacactca 3367261 tcaccacaga cggcaccacc cttctcggcg cagacaataa ggccggtatc gctgaaatca 3367321 tgacagccat ggattacctc atcaaacacc ctgaaatcaa gcacggcaca atcagagtcg 3367381 cctttacgcc tgatgaagaa atcggaagag ggccgcacaa atttgatgtg aaacggttca 3367441 atgcatcctt tgcctacacg gttgacggcg ggccgctcgg cgagcttgaa tatgaaagct 3367501 tcaatgccgc tgccgcaaaa attacgatta aaggcaacaa cgtacatccc ggaacagcta 3367561 aaggaaaaat gatcaactct gcgaaaatcg cgatgaagct gaacagcctg ctgccggcag 3367621 acgaagcgcc tgaatatacg gaaggttatg aaggcttcta ccacctgctg tcgattcaag 3367681 gagacgtaga ggaaacaaag ctccactaca ttatcagaga ctttgacaaa gagaatttcc 3367741 aaaacagaaa agaaacaatg aagcgtgccg ttgaagaact tcaaaacgaa tacgggcaag 3367801 accggattct gctggatatg aacgaccaat actacaacat gagagagaaa attgaacctg 3367861 tcatcgaaat cgtcaacatt gccaagcaag cgatggaaaa cctcggcatc gaaccgaaga 3367921 tttcccccat ccgcggcgga accgacggat cacagctgtc ctacatgggg cttccgacgc 3367981 caaacatctt tacaggcggg gaaaacttcc acggcaaatt tgaatacatc tcagttgaca 3368041 acatggtcaa agccgtaaat gtcatcgttg agattgcaaa gcagtttgaa gcgcaagcat 3368101 aacgccaaaa gccagtccaa aaaaggactg gcttttttgt gtgaaaatga aacattttaa 3368161 acacgtcctc cgtaaaacaa gtatcaacaa atgaggagga aaaacaatga caaaacatgc 3368221 aatcgctgcc aagagtctct tgaaaaaatg gatcatttcc aggccgctta acatgaaaaa 3368281 gaaatccagc ccatttcaaa aaatcagaaa aatgttcaaa cgcttcttca aataaaacat 3368341 caaatcccct aaatacaatc cgtattcacc cgtaccgccc aaatgctccg taatttgggt 3368401 tttttgtgtt caattccgca aaatagggta taaaccaaac aagcaagaaa acagcaccca 3368461 aaaacaggta attcgaatta cgtaaactta ggttaaaagt tatataaagg aatttatttt 3368521 atcgtcgata gtaactatag aaccaatcat caacaagagc aaacagcgta attcaagact 3368581 attttcaggt catcaggtaa tactgtttta gagggacagt ttcttgttat ttattgattt 3368641 agaatttttt gaatactttt tggcatttta tccgtacaat agagagtacc aaaacttttt 3368701 ttgggaggta tgtaatatga tcctatttat tatcatcgca ttatgcggct atcttctttt 3368761 ttctttcagc aaggacaatc gccgcaaacc gcaaaagaca agccctctgc cagcagccgc 3368821 acctcatcac aacaacctaa tcgaccttga cgccatccgc caaaaacgcc ggatgcatct 3368881 ttcctaattc tatatttcaa acgaaaaggc tgctgaatca cgcagccttt taaaattgtt 3368941 ttgatttaga gcctgaaacc ttttcgccac ctatccgtaa tttcatacaa ggcaaaccca 3369001 aaggagactt cagcaatgat cgagttattt atgaaacaaa aaatgttctc atttaaagat 3369061 gcatttcaca tttatgaccg ggatgaacaa gaaacattca aggtggaggg gcgttttttc 3369121 tcgttaggag actcattaca aatgacagac tcatctggga aaacgctcgt ttccatagaa 3369181 caaaaactaa tgtctttatt gccgcgctat gagatttcaa ttggcgggaa aacagtttgt 3369241 gaggtaacga agaaagtaac gttttccaaa ccgaaatttg tgatttccgg gcttaactgg 3369301 gaaatagatg gtgatttatg gagggatgaa ttccaactga cggacgggga aaatgtccgg 3369361 atgtcagtga gcaaaaagtg gctcagttgg ggtgattcct atcacttgca gattgcatac 3369421 gaggaagatg ttctgatttg cactgccatc gctatcgtgc ttgatatggt tttatataac 3369481 gatgaagatg aaagtatttt ctaaaaagca ttgacaattg atccaaaagt aataatatta 3369541 agataattga aatctgaata tgaagttgta ccttatcaag agaggtggag ggactggccc 3369601 tatgataccc ggcaaccgct gtttcaaaca gaatggtgct aaatccttaa gaacattgcg 3369661 ttcttgcaga tgaggcggag atttgatcgt tcaagctctt ccttacacaa aggaagagct 3369721 ttttacatgc ttaatatttc agaaaagagg cgaataacat ggctcaacaa acgaatgttg 3369781 caggacaaaa aacagaaaaa caacgcaaag cacctttccg cgccgatcat gtcggcagct 3369841 tgcttcgttc cgttccggta aaggaagccc ggcaaaaaaa agcggctggt gagatgacag 3369901 cggaacagct tcgtgatatc gaaaatcaag agatcacccg catcgtggaa aaacaaaaag 3369961 aaatcggtct cgatgtggta acagacgggg aattccggcg ttcctggtgg cattatgact 3370021 tcctggaagg gcttgacggt gtggaaccgt tcatcccggc tgaggggatt cagttccata 3370081 acacaaaaac gaaagcgcgc agcatcaaag tgacgggaaa actcgatttt acgagccacc 3370141 cagcgctcgg tgattatcaa tttttacatg agattgccgg taacgcgacg ccaaaattga 3370201 ccattcccag tccaaatatg ctgttttttg gcgaaaaggc ggataaaggg atttatgacg 3370261 atcaagagga atactttcat gatatggccc aagcgtacaa aaaagcaatc aaagccttct 3370321 atgatgctgg ctgccgttat ctccagcttg atgatacgtc atggtctctc ttctttgagg 3370381 acaaaggcag agaggttgtc cgggcgctcg gcggtgatcc agaaacattg ccagccatat 3370441 ttgccaaaac aattaacgat gccgtcgcag accggcctga cgatttaacg atcacaatgc 3370501 acatttgccg cggcaacttc cgctcaacct gggcggcatc aggagggtac gacgctgtag 3370561 cggaaacgat tttggacggc ttaaaccttg acggcctttt cttggaatac gatgatgacc 3370621 gctccggaaa ctttgatccg ctccgttttg tgaagcgcaa ggatctgcaa attgtgctcg 3370681 gcttgatcac atcgaaatac ggcgagcttg aaaatcctga ggatgtgaaa cgccgtatca 3370741 atgaagccgc gcgttttgtc agcttggacc agctatgcct gagcccgcag tgcggtttcg 3370801 cctctacaga agaaggcaac cttctgacag aggagcagca atgggcaaag ctgcgccatg 3370861 tcatcgacat tgccaacgat gtgtggagat aatctatcat tgacagaaat agaaaatgtg 3370921 tgaataatag atactatcag aaaatttaat aaaaaggttt tccttatcaa gagaggtgga 3370981 gggactggcc ctgcgatacc cggcaaccgc tgtttaacag aatggtgcta aatcctttag 3371041 agcaatgatt gctcttgaag ataaggttga gattgtcacg caagctcttc cttatccaaa 3371101 ggaagagctt ttttatattt gaatggaaag aaggaatgga caacatgtca caacaaacaa 3371161 cacccgcaga acaaaaatca cttcaaagaa aaaaaccgcc gtttcgcgcg gatcaagtcg 3371221 gaagcctgct aagatctgag cccgtcaaaa aagcgcggct gcaaaaagcg gccggcgaaa 3371281 tgaccgctga gcagcttcgc caaattgaaa acgacgaaat catccgcatt gtggaaaaac 3371341 agaaggaaac cggcctgaac gtcgtgacag acggtgaatt ccgcagagca tggtggcact 3371401 ttgatttcct ggaaaactta gatggcgttg agccgtttac tcctgagcaa ggcattcaat 3371461 tccataacgt acagacaaaa gcacgcggca ttaaagtcac aggcgatatc gacttttcaa 3371521 ctcacccaat gcttgaagat tactcatttc tccatagcat tgccggtgac gcgacgccaa 3371581 agatgacgat tccaagtccg aatatgctgt ttttccgcgg aaaactggaa aaggatgaat 3371641 acaaaaacga ttatcaactt ttccagcacg atgtatccaa agcatataaa aaagcgattc 3371701 aagcgtttta tgacagaggc tgccgctacc tccagcttga tgatacagcg tgggccgttt 3371761 tcttatcaga aaaaggctta aaacaaatcg aagcgttcgg aacaacgcct gacgagcttc 3371821 gccagctgtt tgcgaaatcc attaacgacg cgattgcaga ccgcccggat gacttgacgg 3371881 taaccatgca tatttgccgc ggcaacttcc agtccacttg gacagcggaa ggcggctatg 3371941 acgcagcagc cgaaaccatt tttgacggct tgaatcttga cggacttttc ttagagtatg 3372001 atgattcacg ctcaggcgga tttgagccgc tccgttacgt aaaacggtct gatcttcagc 3372061 ttgttcttgg cttagtgaca tctaaattcg gtgagcttga aaatccggat gacgtgaaac 3372121 gccgtatcga agaagcgtcc cgttatgtaa gcttagacca gctttgcctc agccctcaat 3372181 gcggattcgc ttcaactgag gaaggcaaca agctgactga agaacagcaa tgggcgaagc 3372241 tccgccatgt ggttgagatc gctaatgatg tttggaaata agcaaagaaa aaaacacact 3372301 tgattcccta gcggagcaag tgtgtttttt atgtcattgt gcggtgtagc ccccatcaag 3372361 gacgacagcc tgcccagtga cgcccttcgc cttctcgctt gccaaaaaca cggcataatc 3372421 cgcaatttcc ttgacggaaa gcagtcgctt ttgcggcaca agcggaaaaa tgacttgttc 3372481 aagtacagag tcgtaaggga catttctagt tttcgataga tcgctaagct gattgcgtac 3372541 aagctgggta tcgacataac ccggacagag cgcattgact gttatgccgt ggggcgcgcc 3372601 ttccagcgcc cctacttttg tgagtccaat gacgccgtgc ttggcgctat tataagcgga 3372661 tttccctgca aagcccacta atccattaac agacgcaata ttaatgattc tgccaaactg 3372721 ctgttttttc atgatcggaa aaacatgctt cattgcaata aagggagccg tcagcatgac 3372781 cttgatcagc tgttcaaagg tgtctgtcgg aaactcttca atcggagcga cgtgctgaat 3372841 accggcattg ttcaccagaa tatccaagcg gccgtattgt ttttggatga cgttcaccgt 3372901 atcagcaact tgcgcttcct ttgtcacatc atacggaatg gccgccgcgt caaagccttc 3372961 ttctgcaagc ttggaggctg ctttttcaca tgcttccgga cggaggtctg aaacgatgac 3373021 gctggcacct tcccgggcga attctcttgc gatttcgaat ccgattccgc cggcagcccc 3373081 tgtcaccaaa gcgacttgtt ttctcatgtc aaacaccttc ccattaagaa ttgagtacag 3373141 actggcttac agcgaaatca gcttctgttt tttcataaac ctcttcaatt gtgacaccat 3373201 cctgaagctc cgtcagtgtc atgcggccgt tcacaaaatc aaatacagcc aaatccgtaa 3373261 tcagcctgtg tacgactttc tggcctgtca gcggaaggga gcatgttttt ttcacctttg 3373321 attcaccatg cttattgacg tgctccatga tgacaacgat tcgtttcgcc ccgttgacga 3373381 gatccatggc gccgcccatc ccttttacca ttttgcccgg gatcatccaa ttggccaaat 3373441 ccccctgctc cgaaacctcc attccgccga gaatagctaa atcgatatgc ccgcctctta 3373501 tcatcgcgaa tgactcagcg ctgtcaaaat aagaggcgcc tgtcacttca gtgatcgttt 3373561 cctttcccgc attgatcaaa tccgcgtctt ccgttccttc cagaggatag gggccaattc 3373621 cgagcaagcc gttttccgac tgaagcatga cgtgaacgcc atcgggtatc tcatttgcga 3373681 caagcgtcgg cattccaatc ccgagattca cattcatgcc gtccttgatt tcttgtacag 3373741 cccgtttgac cattcgtttt ctcgcttcct tcacttggcc tcaccctttc ccgatgcttg 3373801 ctgaactgtt cgtttttcaa tccgtttttc ttggctcgcg ccaagcacga catgctgtac 3373861 gtaaattccc ggcgtatgga tgtgatctgg atcgagctct cctgcttcca cgatttcttc 3373921 cgcctcggca atcgtgatct tgcctgccat ggcggcaatg ggattgaaat ttctcgccgt 3373981 tttcctaaaa atcaaattgc ccatggtgtc cgctttccac gctttgacga tcgccacatc 3374041 gccggtaatg cctcgctcca gcacataagt ccggccgccg aatgttttat gttcttttcc 3374101 ctcggctatg gaggtgccga cgcctgtcgc cgtataaaat cccggtatgc ctgcaccgcc 3374161 tgcacgaatt ctctcagcga gcgttccttg gggaacaagc tctacctcaa gctctccgct 3374221 taaaaactgc cgctcaaaaa ttttattttc accgacatag gaagcgatca ttttcttgat 3374281 ttgcttgtta gccagaagca aaccaagccc ccagtcatcg actccgcagt tattgctgac 3374341 aacggttaaa tcctttactc cctgatctct tatagacaaa atgagctgtt cagggatgcc 3374401 gcacagccca aaccctcccg cgatcagcgt atccccatca tgaatcagtt tcgcagcttc 3374461 cttgcttgat gacagcactt ttcccatatt gatgcccctt tcgttttctt ctacactaga 3374521 ccagtcaggc tgtaaatcgc gatcacagca aatacggcag ccgttttaat gagcgtgatc 3374581 gcaaaaatat cgcgatagga ttgccggtgg gtcaaacccg tcacggccag aagcgtgata 3374641 acggcgccat tatgcggcag tgtatccatc ccgcctgatg ccattgaaat gacccgatgc 3374701 atcacctctg gcggaatatt gtaagcctga atcgcctgta agtattgttc tgacatcgcg 3374761 cttaacgcaa tgcccattcc tcccgaagcc gagccggtga ttcccgccag cgcagttgtc 3374821 gtaacggcgc catttacaag cggatcggta aaagtatgtg aaattccgct gctcagctta 3374881 tgaaaccccg gcagcgcggc gataatgccg ccgaacccgt actcagcacc cgtattcata 3374941 gatgccagca aggcgccgcc aattccttca ttcagccctt ccttcaattg ggcaaacaca 3375001 cttctccaat caaataatat cgttgtgatg atgccaatca ctaaagcaat ctccaccgac 3375061 caaatagcag ccgctgaaga aatatcaagc ctgccgaact cctttaatcc tatggaagaa 3375121 aaatcaaatc cattcggata ccactttggc aggtaaatgg tgaaatattt attcactgca 3375181 ccgacgagaa taagcgggac aaaggcaagc gcgtgccgaa tcgggctttt gtccggttca 3375241 gccgcggact caatcgattc aggagcagga gcattctgcg aatcaaaacc gccatagcct 3375301 tcgccagatg cctgcgcttt cttccgcctt gattccaaat agagcatccc agctgccagc 3375361 acaatcactg cgcccatcaa acccagccaa ggggcggcat aaatgtctgt tttgaaaaac 3375421 gacgtcggga tgacattttg gatttgcggc gttcccggaa gtgcgtccat cgtaaacgta 3375481 aaagctccta aagcaatcgt acccgggatg aggcgttttg gtatgtttgc ttcttggaac 3375541 atgtttttcg caaaaggata tacagcaaat acgacaacaa acaggctgac accgctgtac 3375601 gtcaagacag cacccatcag cacaatggca agtatcgctc tttttgcccc gacaagccgg 3375661 acaattgttt tcgcgattga tgccgcaagc ccggccattt caacgacctt tccaaaaata 3375721 gcaccgagca aaaacactgg gaaatacagc ttaataaaac ccgccatctt ctccataaaa 3375781 attgatgaaa aaaaaggaag cacatggctt ggatctgtca gcagcaccgc gaataacgcg 3375841 caaatcggcg caaacaatat gacagaaaat ccccgatacg ccgtaaacat cagcaaacct 3375901 aacgccaata gaatgatgat cagttccaca cacacatccc ccgtttccgc gaactagaaa 3375961 gcgtttacaa aaacctgtcc gcatcggctg tttccgtccc ctttccatat gtacgagaag 3376021 cgtgggccaa ctattccgat taaaaaagga aagctccttt tttcggagct ttcctctacc 3376081 attcatttca ttcctattag gatatcaaca tcaaccgtaa tatcggctga tttcatctct 3376141 ttcagcaggc tgactcgatc tttcggcgcc gaccaggcaa gcggcgtcat cttgagaagc 3376201 cagtggatcg cctgctggtc aagcgtttta acatagcgca gcctgacagg acggctgtgt 3376261 gctgcatttg ctgtaaaacg ctcaactgct gccgtattgg aatacgtgcg ccttggtgaa 3376321 tcagtatata aaaattgcct taattctatt aaatagtcgc ttcgcggcac tacttttatg 3376381 agcatgccat cattcttcag cagtctatga aactctgcat aattggacgg cgaaaaaata 3376441 gacagaacaa catcaaattg gcgatcatga aaaggagcac gcgccacatc ggcaaccgcc 3376501 cacatcagat ctttgaatgc cttagaagct tttaagatcc cgtccttcga aagatctatg 3376561 ccggttccta tcgctgcttt ccctgcataa tcaaacccgc aaagcgcatt caaatgagaa 3376621 ccctcaccgc aaccgctgtc caagatggtg aatgcctcat gaccagattt gggatgactg 3376681 atgagctctg caatcgcatc atggagcggg tcaaaaaaac cacattctcc aatcagcctg 3376741 ctcctcgctt caaaaagctc ggcaccgtaa ctggttttga ccggcttcgt cagaaagttc 3376801 acgtagccgt gccgagatag atcaaatgta tgtcctcgtt ctgtacaaat caagcttttc 3376861 cctgatgccg catccataga agaatcgcag agcgggcatc gaaacatgct gaaatcaact 3376921 gttcgcttca tgataaaaaa caccccattc attcattttt agataaatga aaaaggcata 3376981 gacaaataaa cctaggccta tctcaaaaat tggccaggtc tggcagtttg tctacacctg 3377041 tcattatcta taacgaatga attggataat catgaaaaaa actccctttc tgctgtatgg 3377101 gtttccccgt ttccatcata caacaaatat ccaggagctg gaaccttata gtgaagaaaa 3377161 atcagtactg acatgctggt atcccgccaa catcatatca gcatagcaat ccagcatgtt 3377221 tttcctttat tttctcattt tagaatataa attttattat tgtgaaaata gttaaaaagg 3377281 ttgattttca aaaagtgaaa ggataaaata ctgctatcat cttagaaaaa gacattcttg 3377341 tatatgatca gtaatatggt ctgattgttt ctacctagta accgtaaaaa actagactac 3377401 aagaaagttt gaataaattt gaacgagttg aaaaggacaa gttcttttct gtttgctctt 3377461 atttttcaca ctttctgcac ttccagaatt tgtgaaggat aagagctttt tttgtttcca 3377521 taataaccct cataggagtt gctatcatgt actttttact aaaccttgtc ggtctcattg 3377581 tgattatggc agttgtattc ctatgttctc cgcagaaaaa gaaaatcaag tggcgcccga 3377641 tcattacgtt aattgttctg gaattgctga ttacttggtt tatgctggga acaaaagtcg 3377701 gaagctgggc catcggtaaa atcggtgatt tcttcacttg gctgattgct tgcgccagtg 3377761 acggtatcgc gtttgccttt ccgtcagtga tggcgaatga aacagtagac tttttcttta 3377821 gtgcgcttct tccaattatc tttatcgtca cattctttga tattttaacg tatttcggca 3377881 ttttgccttg gctgattgat aaaatcggat gggtgatttc aaaggcttcc cgcttgccga 3377941 aattagaaag ctttttctct attcaaatga tgttccttgg aaataccgaa gcacttgcgg 3378001 tcatccgcca gcagcttacg gttttaagca acaaccgcct gctcacattc ggtttaatga 3378061 gcatgagcag catcagcggc tccattatcg gatcttatct ttcaatggtg cctgcgacat 3378121 acgtgtttac agccattcct ttgaactgct taaacgcgct gattatcgca aacctgctga 3378181 atcctgttca cgtgccggag gatgaagata tcatctatac accgcctaaa gaagagaaga 3378241 aagacttttt ctctacgatt tctaacagta tgcttgtcgg catgaacatg gttatcgtta 3378301 ttttggcaat ggtgatcgga tatgtcgcat taacgtcagc agttaatggc attcttggcg 3378361 ttttcgtaca tggcctgacc atccagacaa tttttgctta tctgttcagt ccgttcgcat 3378421 tcctgcttgg actgccagtg cacgatgcga tgtatgttgc tcagctgatg ggcatgaaat 3378481 tagcaacgaa cgagtttgtt gcgatgcttg acttgaaaaa caatctcaaa tcccttccgc 3378541 ctcacaccgt tgcggtggcg acgacattcc tgacgtcctt tgcaaacttc agtactgtcg 3378601 gcatgattta cggcacgtac aattcgatcc ttgacggaga aaagtcaacg gtcatcggga 3378661 gaaacgtgtg gaaactgctc gtcagcggaa ttgcggtatc tttattaagt gctgcgattg 3378721 tcggcctgtt tgtgtggtag aaacattgag ccatatccct tttcggatat ggctcttttc 3378781 attattgata aatagaggct ggcacctgca catcccggat tcccgctgca taaggcccca 3378841 agtcatactg gccgaagacg atggcgatcc cgtttgccgt aaagtaaaac attgtgtctc 3378901 tgtttagggt tatatcctct ttctttacat cagagaaaaa cagcacatcg tgttttttga 3378961 tatagctata taggtaatct ctcgttttgc tgacttttgt tttggtgttc agaatctgat 3379021 ccagcgtcac ccgcttttgt gctttcaagt catagttgaa ggactggaca gacgttagac 3379081 cgtgggcgcc ccctgaatag atataattga gtgtttgaat gctgagcttg cctgccgcat 3379141 tgtatttgac gctgaaggat gtttgatatt cccgttttaa agccctgctg ttcgcctgct 3379201 tttttgtttt tcaggtattc ctgatacgat tgttcatgta ggctttcagc tcttgattga 3379261 ttttcttttc aaacgcggca ttcccgacgt gatgcacttg tggatacgtt aactccttga 3379321 tctttttgta cgtatgggtg ctgacagtcg gtgttttcgc ttgaactgct tttaaagatg 3379381 gggccgcata tgcaaataca gaaaaaagca agactgcaat gcccgcggct ttcagcatgt 3379441 tattccattt catacaatct actcctttga tgtcgttgtt tatcattccc ttatttaagc 3379501 aatacacact tttatagact gattaaatcg aaagaagttt ctaggtctaa cagcatgatt 3379561 tttccaataa aaaaagagac acaggatgtc tcttttttta ctgtttgcgc ccagaaatcg 3379621 cttcatgaag ggcttgtgcc aaatctgtat ttccgaacat ctctaatacc gcaatgacag 3379681 tctggtccgg aatgtgctct gcttcgtgtt ttggcacgac cagatcgtcc atggtttttt 3379741 tcaagctttc attcagcttt tgctgcggat acgctttggc gtacagctcc atcggatcaa 3379801 gatcatggtt cacgcaccac tgggcaaaca ccaaaatcat catattttca tcgcgttcgt 3379861 aagcttcagt gagctgtttt tcgttcattt gtcatgctcc ttatgaaaag tatcttcctt 3379921 aaagatacag gagccgatca aattcgtcta tcccaatggc gatgagcagc aaccgcatcg 3379981 ataaatgcct tgctgaaagc ggtgtagtca ggttcatctt tagccgttac gatgcctagc 3380041 ccctctgttg tcccgacaga ggattgaaga aggtcaattc cttcatttgc cgcaccgatc 3380101 gccttgtagt gattgtaagc ttctctgata aacgccatcg cttgtttgtt gtcttttaac 3380161 tccagtcctc ctgcggcata gacggcatca tacagaacag aatcaaccgt caggaacgtg 3380221 ccgctggcct caagctgctg tccgctgccg cttgtcatat accccagatt ttgactgatg 3380281 atatccactg tgattccttc ttgctttaag gcttccagta ctgtttgcag ctctttttca 3380341 tgaaatccgt ttccggcgag tacagcgact tttcttgttg acgcggtttt cactgtacgg 3380401 gcttggctta acgcaggcga agtaagaatt tctttagatg ctttacgctt cgcgggcgcc 3380461 gccacgccta ctcctttggc gatttcttct gctaaatctg catcgacatt gctgaagaca 3380521 tcaacgacct gccgctgtac gtctttgctt ttgaccttcc cgacctcgaa gcagaaagca 3380581 gaaatgatgt gctgtttctc cacaggagac atgctgttcc agaaaagctt cgcctgtgag 3380641 taataatcgt tgaagctgtc gcttcgctgg cggatttttt tgccctcgac tttttcctga 3380701 tagtggacgt agccgccttc ttcagctgtc gcaggcgacg gatcattgtt ttgcagtgag 3380761 tttttatgat aagcgacagg tcccttattg atcgtcatcc ggtgatagcc gtcgtattgg 3380821 ttgttatgga atggacagac cggccggtta atcggaatct catggaagtt cgggccgcca 3380881 agacggatga gctgtgtatc cgtataagag aaaagccgcc cctgcaatag cgggtcattg 3380941 gtaaaatcga tgcccggcac gacatttccc gggtggaatg cgacttgttc tgtttccgca 3381001 aacacattat cctgattgcg gttcagcgtc atttttccaa tgatcttcac cggcacaagc 3381061 tcttccggcc acagcttagt tgggtcaaga atatcaaaat caaacttgaa ttcatcttcc 3381121 tcatcaatca tctgcacgcc gagctcgtat tcaaccttgc cgccgttttc aattgtttcc 3381181 cacaggtcac ggcggtggaa atctggatct ttcccggcaa ttttttgcgc ttcatcccat 3381241 acgagagaat gcacgccgag caccggcttc cagtgaaatt tcacgaaacg tgcctttcct 3381301 tgttcattga caaaacggaa cgtgtgaacg ccgaagcctt ccatcattct gtagctgcgc 3381361 gggatgcctc tgtcagacat cgtccacatc accatgtggg cagactcagg gttattggcg 3381421 acaaaatccc aaaatgtatc gtgagcagtc gcagcctgag gcatttcatt gtgtggctca 3381481 ggcttaaacg cgtgaaccaa atccggaaat ttgattgcgt cctgaatgaa aaacaccgga 3381541 atgttatttc ccacaaggtc atagtttcct tcttcagtat aaaattttgt cgcaaagcct 3381601 ctggcatccc gcaccgtgtc tgcggagcct ttagaacccg caaccgtaga aaaacggaca 3381661 aataccggtg tcttcaccga agggtcctga agaaatttgg cccgtgtgta ttccgtcatt 3381721 ggttcgtaaa cctgaaaaaa gccatgcacg ccaaatccgc gcgcatgcac aacgcgctcc 3381781 ggaatcctct catggtcaaa gtgcgtcatt ttctcccgga aatgaaaatc ctccatcagc 3381841 gtcgggccgc gaaccccggc ttttaacgag tgctcatcct ctgacactcg caagccttgg 3381901 tttgtcgtca ttttcttccc gctgttatcg gtcctgtact gctcaagctg ctcgtccttt 3381961 gagtgttcat ttacacgttt gttttggtca tcactcatgt ctgctccccc tttttaaaac 3382021 gaaacattct acagcacatt tacccgtggc gttcttcata taaactgcta atccgctcat 3382081 taggattttt ggtctacata taaatatgcg gtcatacaca tttgaaataa gccttcttca 3382141 cagaaagaaa ggatggaagc gcttaccaaa aaagctgttg aataggggag gtcatatcat 3382201 gcttgccata ctcggttttg tgatgatgat tgtctttatg taccttatta tgtctaaccg 3382261 gctttccgct cttattgctt tgattgtcgt tcctattgtg tttgccctga tcagcggatt 3382321 tggcaaagat ctcggcgaga tgatgattca gggcgttaca gacctcgccc ctaccggtat 3382381 catgctgtta ttcgccatcc tgtatttcgg cattatgatt gactcaggcc tgtttgatcc 3382441 tctcattgcc aaaatcttat cgtttgtcaa aggagatccg ttaaaaatcg ccgtaggcac 3382501 agcggttctg accatgacca tttcgctgga cggagatggg acaacaacct atatgattac 3382561 cattgcagcg atgctgcctc tctacaaacg gctcggcatg aaccgtttgg tgttagcggg 3382621 aatagcgatg cttggttcgg gggttatgaa tattatcccg tggggcgggc cgactgcgag 3382681 ggttttggct tccttaaaat tggacacgtc agaggtcttt acaccgctga ttcccgctat 3382741 gatcgccggc attctctggg tgatcgccgt tgcttatatc ctcggaaaga aagagcggaa 3382801 gcggctcggc gtcatttcga ttgatcacgc accgtcttcc gacccggagg ccgcaccgct 3382861 caagcgtccc gctcttcaat ggtttaacct gctgctgact gtcgctctga tggccgcact 3382921 gatcaccagc ctgctgccgc tccctgttct ttttatgact gcgttcgccg ttgccttgat 3382981 ggttaactat ccaaatgtca aagagcagca gaaacgaatc tcggcgcatg cgggtaatgc 3383041 gttaaacgtt gtctcaatgg tgtttgctgc gggcatattc acaggcattc tctccggcac 3383101 aaaaatggtg gatgccatgg cgcattctct cgtttcactc atccctgatg ccatgggccc 3383161 gcacctgccg ttgatcactg cgatcgtcag catgcccttc acctttttca tgtcgaatga 3383221 cgccttttac ttcggtgtcc ttcccatcat cgccgaagcc gcttccgctt acggaataga 3383281 cgccgctgaa atcgggaggg cctccttgct ggggcagcct gtgcatctgc tcagcccgct 3383341 tgtgccttcc acctatctat tggtaggaat ggcaggcgtc agctttggcg accatcaaaa 3383401 attcactatt aaatgggccg tgggaacaac gattgtgatg accattgcgg cgcttttgat 3383461 tgggattatt tctttctaaa tgtatgagct tgatcgtagc attgagtgag tacgtgattt 3383521 acagagggga gaagatcaaa taggatatta tgagtgaata gaagattcat gccaacaact 3383581 tctcattaca atcataagag cctgctatat tgcagcaggc tctttcacat ttggcattat 3383641 ttttttgtat agcgcaccca gtcataatga gcgtatagcg gatttacacc attgtaggag 3383701 ccaagccatt catcgacacc cgtgccattc cacaagttca tcatgatctt tccaggtgtt 3383761 gtcggaattt ggtttgttgc agtatgtttt aattgcccgt cgacatacca tttaatagag 3383821 tttggctgcc aatcgaatgc atacgtatga taggcattgg ctgcatcaaa cccgagatca 3383881 acaatcttct catggtttcc tgcaccattt gtataatagt taaattgaac cttcgttgtg 3383941 tcttttccta aaaattcgat atcaatctca tcccaaggag ttccatctgt tggacctgtg 3384001 taagtgaaga acgatgaaac gatccctgtg tttttagctg gtttcattct gacttcataa 3384061 agtccatagc catatgtttg aacagaacgg ttttccccgc agtcaaactt gttataagct 3384121 gggcttgtta gcgctaaacg catttcaccc aatgacgtca ttgatacgtt attagcccgc 3384181 cacgtgcagt tgaacatatt tccattcgaa taaccatctg ctttttgcca aaaaccggag 3384241 ttatagccgt taaaagggtc aaaaaacgat ccacctgttt gagctgaggc agtagcagtg 3384301 actgcaaaca aactcataaa caatccagtg acaagaagca gcaacactcg tttcagataa 3384361 ggcatattgg cattcccctt tcattgaaag cgttttctat gttgatctta catgattctt 3384421 ttaaaaggga acatcggtca aaataatgat aatatcgaat cttactaact tgaatcctgt 3384481 aactatcatc atcttccctc tgaaaaaaat aaaaacctaa attaccatca gcacagacag 3384541 agatgatccg cactcattgc aatttaggtt ttgcctgctt tatcagtaac aatcctacca 3384601 ttttcatatg tgaatgtaag aaaaagtgaa cacaaggaaa cacaaatgtc agcgctctca 3384661 ttatgcttgt ttaactaccc tttctatgtg aatggttaaa tacagcagct cgtcacttgt 3384721 gagcttgtgc tcatactccc gctcaatgta ggtttggatt ttcttcgtgc attcatacgc 3384781 gcgatgatac ttttctttca ctgtatccag caaaaaatcg tcctggcttt ccatgtgagt 3384841 gccgttaaat agacgctgcg cgaaaaactt taagtgggtg acgaaccgat aatagtgaag 3384901 cgattcttcg ttgaattcaa tcttaaaatg gtattttaca atactcaaaa tctcttgcat 3384961 gacttttgta atgttgataa tattgggcat ctcttcattc agctcggcat ttacaatatg 3385021 cagagcaata aagcctgctt catcctctgg cagagacaca ccagtcttgt tttttaccat 3385081 aaccaacgct tctttgccga tcgcaaattc gtctttgtag agccgttttg tttcccacag 3385141 caaggcgttt ttgatatcaa gccctttctg gttgcgctgg atggcaaagt taatatggtc 3385201 ggtcagcgac acatagatgc tgtcgttgag ctttttgccg agctgtaatt ttgcgtagct 3385261 gataatctct tcggatactt ccatacactc gatcggtata tcatacaaaa gggttttgaa 3385321 cttttctgat acatccttgt tatcgagcgt gaacactttc tcaatgcggg cttcatcgac 3385381 atcatcgccg gactttttct gaaacgcgag ccccctgccc atgacgacca attctttccc 3385441 ctgttcattg accacgctga tcacattatt gttgatcacc ttcgcaattt tcatggcatg 3385501 tccctccaaa tctactaaga acagactata tcttgattgt acattctttt tgtactaggt 3385561 caatatcatc agggaaagac ggaagctggt cagtacaatt cactccgtac ctgctgcccg 3385621 ggctgttttt gaagcagcgc ctccagatgg cgttcaaatg atgccttgtc agctttctgc 3385681 tttttgacaa tgctgttcat gattttaatg ctttcagcac tgtattgtgt atattgtttt 3385741 ttcagctgat ccagctgctg tcttgtcttc ttcgcgtttt tcggtgtgac ttggttgatg 3385801 agtttgatca tactgtctgc ggtctcaaaa aaaccggctc tattttctgt cagctgctga 3385861 atttcgatgc ggctcatatc ttgattacgc gttttttgaa gcaaggcaac cgcctcgctg 3385921 ttttgttttt tgagcgattt gttctcaagc ttaatcgatt cgagattctc cttcgcaatg 3385981 tctgcttctt cttcagtcat gctgattcgc acgaagtatt ctggattgcc gattccataa 3386041 tcaaatgctt cgctcacttg tatcatggaa ctgaacacaa tggccagctg cctgtcgctt 3386101 gcgagggctt ggaaatcctg ctttttctta ctgctcatcg gtttggctgc ggtttgtttt 3386161 actgtctttt gatcacagtc tgcgaacatc tgagcctcac cttcactttc gcatgcgctc 3386221 atcacaagaa ctgtgaccag caggcttata cacaagccta ttcgcctcat gctctgtctc 3386281 ctctctgctg aatcccttct ggaaaatacc ataaaatata gttaaatggt accagatgca 3386341 cctaacccca gcaataaatc aaaagtatga tttgaagcga aaaaacataa atattttgta 3386401 aaaattgacg tgcattccat tcttttcagg cccatttctc gtacaataga agtatcgtta 3386461 ccggagaggg gctctgatga tgaaacgttt tacgaaacaa gaaaacagct gggtgttata 3386521 tgactgggca aattcagctt actcaattgt cgtgaccacc gcggtatttc cgttatttta 3386581 taaatcagca gctgcggaaa gcggtgtcag cgccgctcaa tcgactgcct atctgggcta 3386641 taccattgcg atttcaacgt ttattcttgc gatgctcggc cctattttag gcacaatcgc 3386701 cgactatgaa gggtgcaaga aaaagttctt cggtttcttt gtgtcagccg gtgtcgccag 3386761 caccgcgatg ctcgccttta tccctagtga acattggctg ctattgttgc tgttttatac 3386821 ggtatcggct atcggttttt ccggcgccaa tgtgttttat gatgcctttc tcgtggacgt 3386881 cacgcctgag aagcggatga atctcgtctc ggcacggggt tttggcttag gatacattgg 3386941 aagcacgatt ccatttatca tcagtattgc tgtcatcctg ctcgcacaag cagagactat 3387001 tccagtgtct gtatcggccg caagccagct gtccttcttc ataacggctg cctggtgggg 3387061 gctgttcacc atcccaatga ttaaacatgt ccatcaacgc tattacatca aaaaagaacc 3387121 tcatattgtc atcaacagct ttaagcggct cggccaaacg atgaaacgga tcaggcaata 3387181 ccgggcactt ttcctcttct tgctcgctta tttcttttat atcgacggag tcggcacgat 3387241 tattacgatg tcgacatcct atggatcaga tttagggatc ggctcctcaa gccttctgat 3387301 catcctattt gtcacccagg tagtcgccgc gccgttttcg attatatacg gaaaactggc 3387361 agaacgcttc acggggaaga ccatgctgta cgtcgggatc gtcatttata tgatcgtctg 3387421 cgtgtatgcc tattttatgg agacaacgct tgatttctgg atactggcta tgcttgtcgc 3387481 cacctcgcaa ggcggtattc aagccctaag ccgttcctat ttcgccaagc ttgtgccaaa 3387541 gcgccacgcc aatgaattct ttggcttcta caacattttt ggaaaattcg cctcaattat 3387601 ggggccgctg ctcattgccg ttaccgccca gctgaccggt aaatcctcga ctgcggtgtt 3387661 cagcctgatc attttgtttg tgattggtat tgtgattctt gcctttgttc ccgaggaaac 3387721 cagcacagat gtcagccagc agcaaaatga cctgcccctt taactgggag caggtcattc 3387781 atcatttatt cgctttattc accttcagct gtttcccttt gacggttgtg ttcttcatca 3387841 ctttgagaac atgagggcct ttaccattta aaatctcaac gtatgaggcg ttatccatga 3387901 tcgtgatgat gccgatgtcg tcagctgaca caccgtcaat tttggcaatc gttcctacaa 3387961 aatcaacggc tctgattttc tttttctttc cgccgttaaa atacagcttc ataatgtctt 3388021 tattcagctc ttcgcttttg tcctttttgc tttccggacg gtcattcagt ttagctagaa 3388081 attctggttt cttccttgcc acttcctctt gagaaggtgc ttctattttt tggatttcaa 3388141 atccgatata ttcttcaatg tcggctaaaa accgtttttc gaaggccgtg acaaacgaaa 3388201 tggcctttcc tttgttccct gcgcgtcccg ttcggcccgt gcggtggaca tagctttctt 3388261 tttcaagcgg cagatcatag ttgatgacaa gggagatatt ttcaatatca atcccgcgcg 3388321 cggcgacatc cgtcgccact aagtaacggt actcgccacg tttaaattca ttcatgacgt 3388381 cgaatcggtc ttcctgaatc attccgccgt gaattttatc gcatggatat cccaagtcat 3388441 ccaattcatc ggtcagctga ttgacgtgct ccttcgttcg gcagaaaatg atgcagctgt 3388501 cgggattctc cgtcatcagc acatctttca gcaatgaaaa cttattctct tctcttactt 3388561 gaatcaccgc atgttcaata tttcttgtgg ttaggccggc cgctttgacc tcgatatgct 3388621 cggggttttg catatattga cggctcagct tctcgatatc ctgcggaagc gtcgctgaaa 3388681 acagcatcgt cgtacgctca gtcggcagat gcttgataat cgcctccacc tgctcaatga 3388741 agcccatatt cagcatctca tccgcttcat caatgaccaa ataagagaga cgatccaacg 3388801 gcagcgtgcc tttttcgata tgatccagaa cacgtcccgg cgtgccgaca acaatgtggc 3388861 ttttttgctt aagctcagct ttttgtttat caaaggagga ttttccaaat acggctgtcg 3388921 ctttgatccg tttaaatcgt ccgatgttcg tgatatcttc ctttacttgc accgcaagct 3388981 cacgggtcgg tgttaaaata agcgcctgcg gcttgttttc atcccaattc gccagctcac 3389041 agagaggaat cccgaacgaa gccgttttcc cgcttcctgt ctgtgatttg acgacaagat 3389101 cctttcgttc aagggcagcg gggatcacac tctgctgcac cttggtcggt tctgtatatc 3389161 ccagtccttc caatgctcgt aaaatgtcat gactgatttg atagttttta aaatgactca 3389221 tgtataaact cctgtctctt gcagatgttc tcattatact ctaattgacc aaggcatatg 3389281 tgttttgtcg aaaaatgatg tattaaaagc cagcgattcc ctggcgtttt agctcctgaa 3389341 cagccaatcg cgccagtgcg tcggcccccg cgcgattcgg gtgcagcgta tctccatcca 3389401 tataaagccc gagtgttctt tccggaccga tcgatgtaaa gtatgccgag ctgaggacat 3389461 ttaagtcaat gagatatgtt ttttcctctt cggccaaagc taaaatagag gccctgtacc 3389521 atctgtttac agacgaatgg atgccttcag aagtaaaatc ggttgcccgg ccctgaggcg 3389581 ttgataggat gacgtccgct cctttcgctt ttacctgacg aatcatatca cgcatcacct 3389641 ctttaaactc cgcttcagat tctttatgct tcggatttgt gtcattaatg ccaagctgca 3389701 acataaaata atctccgggt ttaatatact tcagaatcgc ctcaagctgt ccatcatttc 3389761 tgaaccctct cgcgatctgc ccgccagacg ccatgtttct cacttgaaag gtgtgtttat 3389821 cgatatagtg aggcagcatc tgcccccagc ccgcctgctt gctgctgttg agcggataat 3389881 aattgcacac cgtcgagtcg ccgccgacat aaatggttcg attcgttacc ggctgatcag 3389941 acaatttctt tattttcaag gcgctgagcg taaaagcggt gcctgccttt ccctctgtca 3390001 ccagcagatt cagctgcccg tcggtgacgg gaatttggaa cgtatcctcc gcgccatccc 3390061 ctgtcatatt gatgacctga aacacgccct ccgctgccac actggccctt gccgtattgc 3390121 caagcgtcac cttcacctca taaaggccat tcgggagatc aacattaaac gtgttattgc 3390181 ttttcgtccc atacgctaaa aactgaaccg catcactctt cacaccagcc ccggatgccg 3390241 ccacatccct catattctcc ggtgtttgaa aaccgtagcc ctttgaccgg tcataccgat 3390301 cagacgccct gacaccaata taaccaggct ccatcgaacc gcttccaaag tcaaactgat 3390361 acaccttcgg ctccgccgcc ttcacattct caatcccgcc aaaacacagc atcagcatca 3390421 tcacaaaaac cgctgccatc cattttttca tcaagactcc ccctctatga aaacgaatac 3390481 attaatgcat actcggtgat tgtttcttta tgatgactga attaagaaaa aaattgcgtt 3390541 gaggaataaa aatgagggga gagtctcaag aaggggaaaa tcagtgtgac ttcttgtcac 3390601 acttgatcac atcccaacct ccgcaataga agcttatttg gttttcttcg tcatacacat 3390661 aataacggag tctttcccat tgatcgtcag tcggtacaat ctccaatgca accgaatcga 3390721 tggattcaag gtcatccagc tttgatgcac taatgttttc aaaccgcaat tgaatgtcac 3390781 aggtttgagc agatcgtttt cattcaaaca caggaatatg aatataacga tcatcttctt 3390841 tcatatagaa agaaaactcg tttaatgtaa atggacctgt atcctcatca gaaagatgct 3390901 gtttcaattt ctcgtattgt gtgatattca aatgaattcc ctctatttat atgattcacc 3390961 gccaatcata taaatgtcca cagcatcgta ttcaaaccat atgatccgtt cgcctgagtc 3391021 cgttaggcat tggagcttcc cttctgaaaa atagctttta tccggttgag gatcagtgat 3391081 cagaaaaaca tcatcattga tggaagctag cagaaagaga aaatctgcaa tatcccggtc 3391141 tgcttcctgt aatatggatt ggaaatggaa ttcccttttg gccagcttcg tcaccttgta 3391201 agcatgacct tcaaaatact cggacaggtc ttctataaat gaaccagtcg ttattacctg 3391261 tatcatgatt cgatcgtagg caagccctgc ccaaaaacga taaaacgact ctgcatcttc 3391321 aagttcgcat gccataacgg tttggtcagg cttaagctcg atcatgtcca aattgccaat 3391381 actgcttata gaggttattt ccataaaatc ttccccttat cagttggata gcgcaacgca 3391441 aatctcttgt ctgacttgtt catacaagag aatgtgatga tacagatcct tatcgttttt 3391501 gatcatatcc ggaagtatgt caggatacag ctcaaaaaag cttttctcca acgaacgccg 3391561 ctgatgccgg ggtatccttt tattcgccag cacataatcc aaactgccag caacaagcat 3391621 aaaaaactca tagatttccg cttcaaagcc gtacaattca tcagggtact gcttttcttc 3391681 aagctctcgc tgtctttttc tcagtttttg aagcacgttg atcctctccc ttccgcaata 3391741 atctcattta tttcgaaaca gaataggcgg atcattatct atcgcctcca acagctcttc 3391801 accaaacaca gtgattgcac atttccacgg gtctcccaaa agtccccagg agaagtcctg 3391861 atgaaaaaag aaataatagt ctccatttgg aaatacggga acaggccatt cgccaaattc 3391921 atccttaggc attgcctgat gaggactaaa ggtatatccg tcatgctgcc aatctagtgc 3391981 gtacattaca tcgttctttc cagtacctaa ttgaaatgct tttaaaatag aagtctctaa 3392041 atcacttagc actccgctca catcattatg accagcttta ctgctcatcg cgcttgagat 3392101 atcaaacact cgatatggat caggcgggat gatgtgatga catctgcttc cgggcttcca 3392161 ttttatgatc ttgttcactt ctgaccagat gcggtcttgt tttgtctgac ttaaagcgcg 3392221 ccaattcatc ataatctcat ccctacacct tattggatat cctgcttata aacaccagaa 3392281 gaggccactg cgtaaacagc gtaacttgtc agtttcagct gttgaacatc taggccttca 3392341 ccgttcgaat cacagcatgt tatctcttcc atctcttgac tcacatcggc agaaatcaaa 3392401 taaagagacg acttaaggtc tgcactgtaa caattgaacg tcccaaccaa aaaaccttct 3392461 tcggatatcg cgagctgatc aaatgcttct gagtccggct ctttatccga cagaatccac 3392521 acccgtctca cgaccgtttc atcaaatgcg gcaatgactg catctccgta atacagcata 3392581 taaatcaagc cgtttttttc tgcaagtcca taacaatcat ctacagcagg cgcatccatt 3392641 tcttcaagct ttctatcaat gtgtatttcc ttctgctgac catctaacgt aaaacaccac 3392701 acactatggc cgttgggatt ctcatcatga taaatccctt catcacataa accgacccaa 3392761 agctgttgtt tctaatccaa aagacagcag gaaacccctg aaggcaagtg aaaaacactt 3392821 ttcacccttc cctcttctga aaaaaccttt accttcggct cgtacgattc gtaataaacg 3392881 aagacatagc catctgcaca ttgttgaaag agcagaatat cactgtatga aatctgctct 3392941 ttcactctaa aatcccgaac atcaccggaa ggatcataga ttgtaatggt gataccacct 3393001 ttcaaccctt ttccaatgta gacacgcccc tgtggatcag catggaaaaa acaatcttgg 3393061 gtgttctcgt tgatgatttt attcaatttt aattttttca ttggttatgc tcctaggttc 3393121 gaaatgaaat gataagaata aaccatttat tagctattag taacggacaa cctagtttca 3393181 ttaatcgttt tgggataaat ctactttcca attcagcctt aaatcattta gtgtttaatt 3393241 ggtatgcata aaacgattga tcatcaaagc gaactgtttc agcttctata gcaatcagca 3393301 ttctgttcat gtcaataaga aagttagcat ttgattgata ctccggaatt atagaatttg 3393361 atagattccc gattccttct ggatgataac tcatctcaaa tacttgccaa ttgtattctt 3393421 ccggatctat tttttccaat ctcatgtcgc caacatctgc actataataa gcggatgcca 3393481 cattttgaaa tgaaatttta tgcgtatatt caccttcatc ttcaaaaacc ttaatatcaa 3393541 gtgagagttc ttttttaaac acattaaaat ctaaatgaag gacactgcac cccttatcta 3393601 tataatcaac ccattcatta atcgtttgat acattgtcat cccctgcctc tttttaaaca 3393661 ataacgcctt gccaccaagc agaaaacaaa ttactccgta tattgtttga tccaatcatt 3393721 taaatcatct gttgaatgca aataagtttc tgatgaatct ttcaaatcaa tcccacttag 3393781 aaggattaac atatcccaga ctctatcgtc ttctacttcg gggtcatccg cataaacata 3393841 agttccagcc caatccgaca cttcttctct tgttgtttgt ccatttaaga cacttttgat 3393901 tttatttatg cattctatta gatttgtctc gctcaatttg atcaccacgt attcaagtac 3393961 taaatgattt tttattagta tgcaaagcac cgtactgata tttagatatt gaagcttttt 3394021 ccgtaaaaga tatgttccaa aaggtttcca atctaccaat aaacaagctc acatccgtat 3394081 tccgtgtgca atatacataa accaaactgg cacttaggct caaccaaaat aaaactatga 3394141 ttgagaatcc cttcatcgaa ctcaatacac tccaataagc agtcaaggtg ctcgagacat 3394201 tttccaaaag aacaaactaa cgcaccaatt tcgctgctgt attgatgaaa cagcagaacg 3394261 tcccggtcat cgtaagcaac atatgactga gatattttcc agatcagctg tttcgcttcc 3394321 gttttttcga gggcatcaac ctcacgggtg ttggctggta ttgaatttga taaaaccagc 3394381 tcaagcaatt gcctgctttg cgccagatca gcaaaacgat aagtgaagcc tctttctgca 3394441 caagggacta gtttttcttt gatttcgctc atcaataaac gtcttttatt ctcggcgagt 3394501 ttttcgatca atcttttttg catgagccgc attccctccg ctgtcaattt ctcaacttct 3394561 tttaaattga ttcatcattc tcttgttttc gttgtcgttc atgtttagat ttgttctaaa 3394621 aaagcttgta tcgcttatcg atacaagctt tatcttcaac tgcttaaaac tcacccagtg 3394681 ggcttttcac aaaacgctgg gaaccttttt ggcaaatcct cttcatccca atcaattcta 3394741 tatttttaga ttcttttgtc atacaaataa gagaggatgg taacatctct tatttaatgt 3394801 tccatcaata aatgccccat ttttatccaa tgcagaaatt atttataatt aaggaagttt 3394861 agaaggattt tttgtatttt caagatttaa ttttaaagcg gtcacaaaag actctagctt 3394921 ttcttcatta caattaattt cgaacaagtt ggagttcgac ttactttctt tataatcatc 3394981 aaatataatt ttaatcttaa ttctgtaatt tccgttttct tgatcaatac taagaaataa 3395041 gaatggttca atagtctcta aactgatact gtcttgattt ccttttatca tagtttcgat 3395101 cccagatatc aacaccttat attcactttc taataaaaca gcagaaaaat cgcgaacgac 3395161 ggctttctta ttttccaaca attcaaatac agataaaata aatggatcat cgtccaactc 3395221 ttgatacctt ctcggtgtta attcaagttc tatacaatca tcttttattt tggccatatt 3395281 tcctcctcat ttaaagttta agtgagggta gttgtcatcc ccccctcgct taaccttatt 3395341 aacgccttct cttagattta tttccttttc cgtgtgtatg gaatacgtgt ttagaaccct 3395401 tagctcttga acttccataa gctgtgatta ctttacccct tttatttaaa acaactgtag 3395461 ctttttttcc aacatatttc gttgccccat taggttgttt tattactttt ttagggcttc 3395521 gcacagcatt cagtttggcc cttaaattga ctccacggcc tccatttctt cctatagatt 3395581 gattaagtcc atgtcttgta tgacctgtga ttttaactgc cttcttcgta aacttatagg 3395641 cgcgactagc acccttaaat atcttcccag gaccaaaatt agaagcagct gcccaagcag 3395701 cacctttcca tcctttacct gatttatatg ccttatatcc atcataggct gcaaatccgg 3395761 catttaccac aagccatacc caatgcccgt ccggatcaac attcatcact gggttattat 3395821 ttccataagc atacccattc tgatccaatg aatctccgtc gctgcccggg tctgggtcga 3395881 gcgataggaa cacgccgttt cttggctcgt agtagcgggc catgagatag tacaggccgg 3395941 tttcttcgtc gtattggtag cctgcgtagc ggtagcgatt gtcttttact tcgtcgcttg 3396001 cttcggtttt tgttggattt ccccatgcgt cgtattgata cttggcaacg gtttttccag 3396061 tgctgtctga gatcgcgatg atgtcgccgt gagcgttgta gtgatagaaa tatttcttac 3396121 cattttctgt gtaggataac agctggccgc tgtctccgta cgtgtatgat tttgtgacgt 3396181 tgttgtccgc gtctgtttca tacaagacgt tcaagctgtc tccgtcgtag aagtagttcg 3396241 tgacttttcc gttgacggtt ttttggattc tgtttccttt ttcgtcatac ttatatgttg 3396301 cgaatggctt gtcttcgcct tttttggtaa cggcggtcag gttatcttct gcatcccacg 3396361 tatatgtgaa tttgccgtcg gatgtgcggt tgccgttttt atcgtaagag atgctttcat 3396421 cattgacttt tgtcagctgg ttcatgatgt tgaaggaagc gttcaccgtt ttgcttgagc 3396481 cgtcttttat agttgtaacg gttttccggt ttccgaatcc atcatatgtg tattcaataa 3396541 cagtaccgtc ttcatgggtt tctttgacaa gctgattcag cttcccatac tcatattgca 3396601 ccttgccgct tgctgagctg tttatcgttg tgcggttgcc gttggcatca tattcatagc 3396661 tttccgtcag aatgtctccg ccgtttttgt caccgatatg cagcgagctt acaaggtttc 3396721 tttcgtcata tgaaaaactt gttccgccgc cgttgcccgt aataaaggtt tggacgtttc 3396781 cattttcatc ataatcaaat gaatatgagg atgtactgtc tttcatctca atcatttgat 3396841 ccagcttgtt atacgtaaat tgattcgttc ctttttggtc cccatgaatc cacgagaagg 3396901 ttttcagctt atcggagtca ctaggatatg tccaagtttg gctgccgccg cggtctgtca 3396961 gttcggttaa acggtttttg ttgtcaaatg tccgtttctt tgtggtgttc tgctctttat 3397021 tgacgaccga cgtttcattt ccatttttgt catacgtgaa aatgtacttt tctgtaccgt 3397081 tatacgactt tgatttcacc cggtctgttc catcataaga aagagacact tcgttgccat 3397141 ttggtgaaat ggttttggtc aggttgctgt tggcatcata ttcgcttgct aacacattgc 3397201 cgagagggtc agttgttttg acaagcttgc ccatgacatc atattcgaat ttataggttt 3397261 gatctgctcc tgcccggatg gttttgctta cctcattgcc ttccttatca tagctgtgaa 3397321 ggatagacgt gccgttagag agcgtcatgt ttgtcaattg gtctgcctga tcatacgtat 3397381 aggttgtttt ttcacctttt gcatctgttt cagacgtttt cttaccagtt tcatcgtaat 3397441 cagttgaagt ggcgtaacct agttcgtcct cttccttggt cacatagttg ccattactgt 3397501 catacgtgct tttagtcaga aggcttcctt caatcaaacg gatatcatca aaccagactg 3397561 tgcctgtcgc actcttttgg aacagaatac tgatatcgac tttattgatc ggctttgttt 3397621 tagggatgac gacagctgct cggttccatt cctgtgttcc agaagggaat ttcgcattgt 3397681 agatgcctgt gctgccgtca gcgtaagtga cattcgcctg cagagaatag tctttttcat 3397741 ctgtaaattt gacgctgctt gctttcgaca ttcctgtcag tgtgagataa accggtttgt 3397801 catttgcgct ttgccctaag acaacggttt gttttgttac tgatccggct tgggacgcac 3397861 tggtccgggc agcttttaat gatacatcat cattaaagcc ttcttcagaa tcaacggatg 3397921 ctccgcttac attccagttt tccgttgctg atgtgaagct gctgttttga actgggttat 3397981 agcttgatga tacttcgcct ttttccagct ggacttcatc aaaccatgct tttcctttgc 3398041 catctttatc tttatgatcg acttccatat acacaacagc tttgcctgca ttcgctggag 3398101 tcgtaaaagt gatttgccgt tttgtccagt cattttttcc ggctaatgca ctgtattcat 3398161 tgtgaatcca ttgaattcgt ttttgatctt tgtctcgcaa atcaatgtta aaataggctc 3398221 ttgatttcgc aagatctgtt ttgattttcc cgcttaatgt ataggttgta ttcggctcca 3398281 gctcaactgt ttgtgttgct gacgaatacc catgatctgt tccggcagac gttgattggc 3398341 tcaagacctc caatgccttt gatccggaaa gaactccgct tttatcggcg atgactgaaa 3398401 ttttgccgct gtctttagag gcagtcagat tccagccgga tttttgagct tcaaagcttc 3398461 catctttcaa aatattagtt gaagctgata aatctttgct cgattgaatc tggtttccat 3398521 atttatcata aacagctgct gacgatgatt ttccgctctg atcggtttcg gatacagcat 3398581 ccagtccgtc ataagcaata tccgtgacat tgccctcggt atccttcatc tttgtgacat 3398641 cgttgttttt gttgtattcg tatgtctcag ttccatatgc atctttaacc gacgtaacgt 3398701 tgccatcttt gtcatattga tagctttccg ttgcttttcc ggtgccgacg tcatttggat 3398761 ctacatcttc tacaacattg ttgccttcat actttgtatt cgttgtaatt tttaaccctt 3398821 ccgcatcatc aatgacctga atcggatttc ccgcttcatt atagccatac tgtactttcc 3398881 ggccatttgg ctgtgtcatg agaagcgtct ttttatcagc atcatagctg tagacatatg 3398941 tttctttttt agcgttgatc gctttttcga gacggtgacc gctatactga tattcggtaa 3399001 agacaggctt tgcttcggta ctgttagctg aatattgttt gacaaggcgc ccttcactat 3399061 cgtagtcata gcttgtgaca gtcccgtctg tatctgtaac cttcttcagc aaatcattct 3399121 catatgagta ggtgactttc ttattcttag gtcctgtgat ggacgtcaca tggccgtttt 3399181 catcataggt aaatgtaagc ttgcggcctg atgcatctgt aatggcggtc agttgatttt 3399241 tgtcattgta agtatagaca gttgcattgt tatggccatc cactaccttt tggagtttgc 3399301 cgcctttttt attgaaataa gcgttggttt gatcctttgt ttttaatatg aactgatcag 3399361 ctgtttctgt taattcaaga tatacaccgg tcggcggctg atacgtgcca tcggcttttt 3399421 tcgtgaatcg atgtgtcgta gcgtcttcat cgatatacat tgccccgcca tccgttgaga 3399481 tgacagatgt ttctgcatca gcataccagc cttgtccaaa taagtgatca gagctgtcaa 3399541 gactgttgta ggttctcgat aagccaagtc ccggaccgcg tccatcaatt gacaaatctt 3399601 cttcattcac aatgacattg cctgtcgcac catttaactg gccgcttggg atatcaatga 3399661 tagaccagta ctcttctgta cctaggaatt ctgcgccttc atggaacgtt gggttaaagg 3399721 gcgccgttgg aatcgtttca ccattcgcat cataggcgac aagcgtgaaa gaataattct 3399781 tcttcccttt gtaattccca tttgcattgt tatagacagg tgatggatcg agggctaatt 3399841 ccccgccttt tccatctgta tgaagcttat agcttccggc tttgatttcc tcagaagtcg 3399901 gccagatgtt tttattttgg gttgtccaat gatcagcatc accaacatca aaggactgat 3399961 attctttacc gttgtaaatg ttaactttat agcccttcgc attttgaacc ttttcccata 3400021 tcaaattcac ataacccgtt tgactcgatt ttgtatttgt atacaaatag ccagttacat 3400081 tctttggcct agcgatatca ggaagtgccg gggtagcagc cggggatgca atggcttcgc 3400141 cgtctttgtt gtatgcgata attttaaacg agtaatttct tttggctcca tctcccccgg 3400201 cgtttttata ggttggtccg ggattgatcg gcagctctgc tccgcttccg tcctttaggt 3400261 gaagagcata ttttcccgcc ttgatttctg cacttgtcgg ccagatcttt ttcccttttg 3400321 tggtccaaga cgtctgattt ccgagatcaa gtgtctcaaa gcctttccca ttgaacacct 3400381 gaaccttata gccggttgca ccggatacag ctttccaaga aaggtcgaag tatcctgtgg 3400441 cattcccatt attgtagccc tttgctgacg gtgcttgtgc ttttcctaca ttagggataa 3400501 cgggctttgc cggtgcggac atcgctcctt caccttggtc aaatatcgca ctgacgccaa 3400561 tccaatagtt tttgcttgta gcatagcttc cgccggaatt cttatagacc ggggatggat 3400621 ctaatgccaa ttcagctcca tccttgccgt ccagatgcag tttatatctc ttggaggcaa 3400681 tttctgcgct cgtaggccag atttttttac cttttgtgct ccacgacgtg acgttgcctg 3400741 cagaaatcgc ttgatattcc ttaccattgt aaatccatac cttatatcct tttgcgcctt 3400801 caaccttttt ccagctgata tcgaaataac cagtggaatc gccgttgtga taggctttga 3400861 ttgtaggtgt gtttcccttt ggaatggtat acgtcacttc aatatatggt ttattggcgg 3400921 agttcgctga agaaattagt tttttccaat attccttgcc gtttccgttt gtatgaagct 3400981 taaatccata gttggccccg ccggagttcc atgactttac agcagcggtc acatcataac 3401041 tcgcccactg tcctttatgg acgtcggctt ttccgatatt tttagatgcc ggtttggtgt 3401101 tccatgtcac ttttgcatta tcataattgc tgttgaccgt atccagccaa aggccggttg 3401161 cctttgttcc ataataggaa tgggctacgt atgtttttaa tgtagcttta gtgacagtca 3401221 tattttgaat tggctttagg ttgttaaatt tcatgaacgc atagtttgtg cctgttgttt 3401281 tgtcataata gcccgttttc agtacatagg cctttaaatt agcatcccat ttttgtgagg 3401341 aggccgaata gttcgtcgtc gggtaggcac tcatgacaaa cgtatccgat gaaacagata 3401401 aagaagttga cgggtcgata gatactggat atacgcgttc tgggtctttc agccagttct 3401461 cgtctgccgt aagatgaagc aaataccctt cttcattctt ttccagctta tagctgactt 3401521 tgtctgaccg ttcaacctcg ccggaaagct catctagttt tgaatccgtc ataaaaggct 3401581 taggcacaga aaaaacaact tttccttttt catcagaaaa atcaatggat ccatcctctt 3401641 gttctttagc ctgcaaatcg gtttttaact gaaatgtaaa tgtgttgtat ccattatact 3401701 gatgaaggac taaatcttct tttatgtttt cattgaatgt gaaagtctga agatcaatat 3401761 tcggaaacac atccggatac acaatctcat tactgtcagt cttataatct gctgaggtat 3401821 ctttcggagt aagtgaagtt ttattcgggc ctttcgcttc tgctagtgaa tatgtaacct 3401881 tatggtcatt atgctcaaaa gtcgcataaa gcccgttctt catttgcttt tgaaaatctg 3401941 aattcaaaat agcgttctct gtctcgactt gtttgcttgt cgactctttt aactcaggag 3402001 aaatgtcttc ccagtcggca tccggtgttt cctttgtatg aataggatca aggtatactt 3402061 cctgtttata gacaccgtca ccttcataat agagttttgt attttctgtt ctttcagagg 3402121 tgatctcacc ctctttgttt atatcttttg gatcaaaagg tacagcttcc tcagtttgtt 3402181 ctttctgaag agtttcttct ggatcatcgg cagcaatacg gtttccattc tcttcttctg 3402241 tagattttgc tagtacatcg gctggcacta atgaaatcat taaagccaac actaaaaatg 3402301 ctgcaatgaa ccttttaaag tttcgcctct ttcttttttt catttcctct ctccttttgt 3402361 aataaaagta atatttactc aataatctta actagactga aatatcatta caatattttt 3402421 ctagaaaatt tatcttattt taaggattag cgagagtcaa ttgacctaaa acaaaaaaag 3402481 gccgcatagg cctttttaca ttttttattg tatttgttca atatccgtac cctcagctgt 3402541 cacattcgcc ttcccctgcc tcctgacaag cgtcaaggcc atgcccgcaa agatcattac 3402601 gatgccaagc gtttgataga ggtcagggcg gaagcctgtg aagacggtat cgagcacgat 3402661 cgcgacagcg gggtcgagaa atacaatgat tgaaataaat ttcgttgata aaaatcgtaa 3402721 actgtcaaaa aacagcaaat atacaatacc cgtatggatg atgccggtag ataccaccat 3402781 aatccagttt ccctgagata ggtccgcaaa agcgccaaag tgaataaacg gaatcaggat 3402841 gataacccct aaacctgtct gcaagaaggt ggtcgtgtaa ggactgagat tgtgaatgcc 3402901 ttttcccaat aaagtggtga acgcataaaa cagtgcggcg agaactgccc atatgatccc 3402961 tgatcccatc agctgtgtca atgatgtgct gccgttaatc ccggaaatca gcgcagtccc 3403021 aagaaagcag atgataatgg agctgacgga gatcacattt aatttctctc tgtagaagaa 3403081 gctccccaga agaagaacaa gcaccggcgc tagatgataa acagagatgg caattgtaac 3403141 ggacgtttct tcaaaagact taaataagaa cacccagttg aatacaagaa agaaaccgca 3403201 cgccaatgtt tgcagcacgt ctctcttgct ccatttttca gttttatact ggccggacgc 3403261 cagccagcaa aagcctaaaa acagcgtcgc gcaaaggcag cggacaaaga ccaattcaaa 3403321 tgacggcaga ttggtatgct ctgagaaaaa gccgatggag ccgaaaatca ccatagagat 3403381 gaccattttg attacggctg ttgatttttg ttttgacgat atggaaggat cctgttgcat 3403441 caaacgtatt ctacctccaa tactgcatag cataaactgt tttttgtgaa ttcagaaatc 3403501 tacacataga attcctcttt tttacatgta gatattataa cacttctatt ctaaataaaa 3403561 aaaagcgccc aagggcgctt tttttacaaa tctatcgaac aatcaaaacc gggcatgttg 3403621 ataattgaga cactttatgg ctgacgcttc caagcatcat ttctttcagg ccgctgatcc 3403681 cccggctgcc aactacaatc aggctgacgc ctttctcttt tgcgtgattt agtatctcat 3403741 gcgccggctc gccattcgcg taaatggttt cagcttgaac gcctttttcg gctgcttttt 3403801 cttttgcatt ctcaaggatt ttcaggccct cttttttaac ctcgttcctg atttcatcaa 3403861 taaagtgttc aggcacatag acaattcccg tcagagaaga agtcgtgacg acggcttctc 3403921 tccccacatg aagaatgctt agttccgctt gttgctcttt tgccaaatgc actgcggcat 3403981 caagcgcttt tgcactcatg tctgatccgt caatcgctac taacattttg ttaaacatgc 3404041 tcttcccgcc tttcggactg tgggtggttc atctttctct tttattgtcc gcctgcattt 3404101 cgttattgtc aattgaagcg catgagtttt caaaaaattg tcagagactc tctccgtttg 3404161 tggcgataac ctgctgatac cagttgaagc tttttttctt gatgcggtta aatgttccat 3404221 ttccttcatt gtcccggtct acataaatga agccgtagcg ctttttcatt tccgcagtag 3404281 atgcgctgac aaggtcaatt ggcccccatg atgtgtatcc gattaattca acgccgtccg 3404341 caatggcttc gcgcgcttca attaaatgat cacgcagata gttgattctg taatcgtcct 3404401 gaatcgtgcc gtcctcttca accttgtcta cagcgccaag gccgttttca acgatgaaca 3404461 gcggcttctg gtaacggtcg tataaggtgt tgagcgtgat gcgcaagcct ttcggatcaa 3404521 tctgccagcc ccattctgat gatttgaggt aagggttttt gactccgccc agcaggttgc 3404581 cccctgattt tgcaagctct tccggatctg tgctcgccgc catcgacatg tagtagctaa 3404641 atccaatata atccaccgta tgttctttca agagctcttc atcgccttca gccatttcaa 3404701 tttcaatatt gttttctgcc agatagcgtt tcatatatcc cgggtatgcg cctcttgcct 3404761 gaacatctga gaagaaaagt gttttgcgct cattctccat tgccgcgaag acatcctccg 3404821 gcttagaagt catcggatag gttgtcgttg ccgctatcat acagccgatt ttcgaatcag 3404881 gaatgatgtc gtgacccgct ttgacagcaa gagcactggc cacaaattgg tggtgtgccg 3404941 cctggtacat cgcgtttaat ttgttttctc cttcttcaaa aacaagaccg cctccggtaa 3405001 atggcgcatg gagcactacg ttaatttcat taaacgtcat ccaatacttc actttgtgtt 3405061 gatagcgttt gaaaaccgtt ttggcatagc gttcataaaa ctctatgact ttgcgattct 3405121 tccagccgcc ataatttttc actaaaccga gcggcatctc ataatgagag atggttacga 3405181 caggctcaat atgatgcttt aacagctcat caaacagatc atcataaaat ctgaggcctt 3405241 cttcattggg ctcctcttca tcgccattcg gaaaaattct cgtccacgca atcgatgtgc 3405301 ggaacgcctt aaatcccatt tctgcaaata aggcgatatc ctctttataa cgatgataaa 3405361 agtcaatccc gttgtgatac agattcaagg aagtcattga ttcatcaaat ggagacatga 3405421 tcccgttcgg cgatacgtca gctgtcgaaa gccccttacc accctcgtta taagcaccct 3405481 ccacttggtt ggcagcaact gcgccgcccc ataaaaatcc ttctggaaat cgtttttcat 3405541 ttgaactcat attgatcacc ccattagttt tttcaagata aagcaagcag cgcttctttt 3405601 ggctgcactt taccgatctc tttcaccggc gaaaacgaat attggtctgt gttggtcaca 3405661 atcaccgggg taatgacgtc atatcccgcg gctttgattt gctccagatc aaaggacacg 3405721 agcggatctc ccggtgcgac cttgtcgcct tctttgatgt gagccgtgaa ccattgtccc 3405781 tccagcttta ccgtgtccaa tccaatgtgt atgagtattt cagctccctg atcactcgta 3405841 atgccaattg cgtgttttgt tttaaaaatg gtggtaacgc ttccacgaac aggcgaaaca 3405901 acttctcctt cttcaggctc aatggcaaat ccttttccca tgaccccagc agaaaacact 3405961 ccgtctttga cttcacttaa ggctttcact tctcccttaa tcgggctgtg aatgatctct 3406021 ctgctgcctt catgcactgc cggctgctgg ctgccgtcag aaggcacatc ctcgaatcca 3406081 agcaaatacg cagctgctgt tcccgccgca aacgcaatca caaggccgat catcgcgtaa 3406141 ataaacgttg ggccgataaa gacagggatg ctcggcagac ctgcattccc cccgacgata 3406201 taggaagcaa cacccgtcat gccgtaaaac gcgccaccgg ctgcaccgcc aatcaaagcg 3406261 gccgcaaacg gctttttcaa tcgcatattc acgccgtaca tcgcaggttc tgtgatcccc 3406321 atcagcgccg tgatgcttgt ggtaagcgcg agtgatttaa attttttgtt tctagagcga 3406381 aggaagacgg caaatgatgc tcccgcctgc cccatattcg ccaaaaacat agccggcagt 3406441 aaataatcgt ggccgttttg agcgatgttg ttgatcatga tcggcacaaa ggcatagtgc 3406501 atgcccgtca taatgattaa agagaatgta cccgccagca aaatcattgc cacaagccct 3406561 gcatgatcaa acaaataatt gaccccagaa gacaagtatt ctcctaaaat agcgccaagc 3406621 ggaccgactg taatcaatgt cagcggcacg acaatcaata gcgtgaatgt cggaaccaca 3406681 atcaatttga gagatgcgtg tgtaaaacgg tcaatccatt tttccacgta tgaagcaatc 3406741 caaatcgaca gcaaaatcgg gatgaccgtt gacgaataag tggcagcggt tacaggaagc 3406801 ccgataaagg aaatcggttt ccccgcaccg agcagggctg tcaaatccgg atgcaggatc 3406861 gccgccgcaa tggcagccgc tacgtacgga ttgcttccga attttctcgc cgcactcatc 3406921 gctagcagga gcggcaggaa gtagaacgca ccgtcaccga cagccgtcaa aatgacatga 3406981 acctggctct tctccgccat ccagccaaac gtgactgcca gcgccacaag tcctttgatc 3407041 atccccgctc ccgcaatcgc aggcagaata ggggtaaaca ccccagaaat cacatcaaag 3407101 accgcactca gcacattctt tttctgagag gatgaaccag cgctcttttc atcactgaga 3407161 ttgctgtgcc gcacaatcgc ctgatacacc ttcggcacat cgtttccgat aatgatttga 3407221 aactgctcgc cgctgatatt ggtgcccatc actccaggca gctgctccag ctgactgcga 3407281 tccgccttcg cgttgtcatg aagattaaaa cgcagcctcg tcatgcagtg gatcacgcgc 3407341 tgaacgtttt cttcaccgcc tacgagttgt aatatgtcct tcgataattt atcataatcc 3407401 atgtgtatac ctccttttta tggggggact gctggatgaa aggtggccgc ctttcaccag 3407461 ctttttttgt atcaaatgct gcatcacctc ctaaaagaga ataaaaaaac ctaaatgaca 3407521 cagattgcga gagtctcctc ctgcacctgc accatttagg ttttgcctgc tttcgcagta 3407581 acaatcctga cgggtcgttt tatttgtttg taggtatact ttagcactag attcgtgaga 3407641 tgtcaacgct ttcatttttg gtgttgacta tcgtttctag aacaaaagta atcataaaga 3407701 tttgaactta gtattaactt caataaaaaa ttattgtaat taaaaacctt gaaaggcatt 3407761 ttttccaatc aaggttatga atcgttaccg tttaaatttt tttaaagact tctttatctg 3407821 tactattaca ttctttagcc aatctattgg ttctaaatta aacgcaggaa gatacacgcc 3407881 atctgcgcaa gattgaatgt aatcgttttt cttattgtct gaatgctcac tttcaataaa 3407941 atccgttaaa aagacaatag catcctccaa atattcctta ctttcctcta ttaataactc 3408001 ttgtatagcg tcatcaggag tttcaatatc ttgatggaat gttccagcta aaaactgaaa 3408061 aacagggtcc ttctgtttat tgatcaataa catgtcatct tgctccttta agggagaggt 3408121 aacgggataa tgttaaaatc attcatcatc taataaatca agataatact gatcattctc 3408181 ttctattttt cttaagaact cggtaagaga agttgcaatt tgaatatcat aatagtaaat 3408241 cggattttta ttattatcat ttaattcaat tgacattaat gccgattcac taccttcaaa 3408301 aaatattaat ttatcattct caaactcatc atatatttct atgtcaggat aaaattcaaa 3408361 gtcatttatc ctcaatcgaa agtctcttac agaatatgga tccaaaatgc gattagtatt 3408421 aaactctgat cctttaataa acccatagcc aacttctaaa taaaaattca ctaattcact 3408481 aggtaatttt aagtttaaat ttttttcaac ctcttcaatc tcactttgat tcactggata 3408541 aaaatcattt tctttgtttg attttataaa attataactc attttttttt gcctccttta 3408601 aataattcat ttgctggtga gcctgtacca tgaatcccag cttgatgctc gttaggaaat 3408661 tttgctggat gcatattcca ccattcatgt tctccgccaa aagtattttc aattatatgg 3408721 tgagcatcat acttatcccc tttttttcta ataattttac ctgttttttc agatacaaca 3408781 ttttccttat aaacaggcca tttttgtcca gtgttttctt cccattcttt tataacttta 3408841 ttttttactt tatcaaattt agtcctgtgt tttgcagtct ctattggtga cattttttta 3408901 tattctttat ttcttaatgc ttcctttaat ttatctattt gatttttagg taattctcta 3408961 cctgtgcgtt gttctatatc tctagcatac ttttttatta aatcagaatt aattttatta 3409021 gcagatccac ttacatcatt cgcaattttc cctttatcct tagcaacgtt tttaacttcc 3409081 gaagccttct tagccttttt cccattatta ataagtttat taatatctat taacttttct 3409141 aacttagcta ttttggcaaa tggtactgag tttatggagg caacaacacg gtctttccct 3409201 gtgacttttt cgcctgatac cggatctctg cccgtggctg ctttaaatag atcatacacg 3409261 ccggtaagtt ctacagccgt ctctaaaatt ttcacatatc cattctcatc cactttaatg 3409321 tccgaaagcg agacgacagg ttcaagcttc atgtcattac cagatatgta tacattgtaa 3409381 agtgtatcat tataaacgac ttgcttaacc tctgcatttg agaaatcagt ttttatatgt 3409441 tctctatgtt cactcgtatt atacacttta ccattgataa cgatgatatt tttacttacc 3409501 tttttagaat cacccgtttt gacaactgaa tccactttag acttttcatt ctcggctaat 3409561 ttcttcagca tcatctccat cggtgaatca tccgcctgct tcatttgcgg gttaatcgcg 3409621 ccgaagattt ggttgatgtt ttcttcttcc tgtgatttca ggatggagcc gcttttgtag 3409681 cctgtgattt caattttcgg gccggtgtac atggtttcga gctgatcaat gtattttttc 3409741 atcgtttgaa aatctgattt tgcggcttct agtgcttggg tttgctggcc gtcaaattga 3409801 aagagcttat tcagggtgtc tgaaatcagc cgctcagcct gttctgtttc catccgaaaa 3409861 aaggaatcat tgactgtcgg caggctgacg atgtgatcta tggctgatgt ctggcgattg 3409921 actgcgtcag tgagctgctc tgtcacttct cgtgcatgct tgaccccatg tctcgcatcg 3409981 tgtgagagaa aagcctctgc gatcatgccg tgggagttag attctacaga ggaaatcgca 3410041 tgctgtgttt gtttcagcac ttttttgtat tcgtcgataa atatgccaaa gaaaaggaga 3410101 aaaggcttgt ggcactcctc gtaaaaggtc cggatggcat ctccgccttt tcctttcagc 3410161 gcatccttca tgcctgccag atgctcaacg cttttttcca gcttctccag ctgttgtttt 3410221 tgcttgtcca gtttctcaat cgtatgctga atgccctcgt gaagagcgtg gacatctaat 3410281 gttttcaatc ccttgtcctc ccgcgcttta tttcatggaa gatgatatgt tttcgtccgt 3410341 ttccttcatg gcgtttaccg cgctttccgt ttgtgcgata tgcttggcca gaacagacgc 3410401 atatgcttca gtgagctctt tgatgtcctt atttaattgc tcgatggact tcacaacatt 3410461 caaatggttt ctgcctgaga gatgaccggg caatgaggac ttgagttcag ctgaattctt 3410521 gagctgagaa agcccttgct tcactgtgtc atacaccatt ttaatttcct gtgccatttg 3410581 tgctcacctc actttttatg tttttccttc tctatttcat gctctatcct cgtgatttgg 3410641 cgtcttatag aatacacatc gccctctaat gagtggattt ttccttctat gctttcgatg 3410701 attccgctga cttgatcgct tttgatttgc tgatatgctt tgttcattcc ttcacgaata 3410761 tcttcaaacc gctcagcatg tgttcctctc catgcctccc ggttaagatg aggccggtga 3410821 atgagatgct gggcctcaga gaaatcgtgt ttgatttgcc taatttcgtg cagcactcgt 3410881 tttaattgat ggatctgttc ctgcttttca tgtaagtcgg cttttaccga atgtaacaac 3410941 atttcactat gcatgccgca acacctcgtg tttctatcaa actgtgtaaa ttctttacaa 3411001 tacagactat tttcatatta catgatgggt catattggat aaataggtaa aaaggattgt 3411061 cttgagaggt atagaactgg ttctaaattg ctaaaaatac gatctcatca ccctatgaaa 3411121 ggagaaaaca atcatagtag ggacttttta tttaagcctt taatctctcc tccagttcta 3411181 atttttcctc ccacttaact gtttcttata gtcaataaag ctcataaaaa aacaccttcc 3411241 ctcgaaggcg cttctccatc ttatttagat ccccatacag cctcaccgct ggtattcagc 3411301 acactaaacg tcatgacgtt cttctctctc accgaatccc actggcgtaa aaataccccg 3411361 ttatacttct tgcctgctaa cgtgatgtcg gcggtgtttt ttccggtttt cctccatgtt 3411421 ccggtcattt ccccggaaat ggtgtggttt ttgttgagct ggatgttgat ggtttgtttg 3411481 atgtcggctg agatgtcttt tccgtgctgg ataagtttgt atgttcctgt gatgtctttt 3411541 tgttttactt ctttcaatgt ttcgcccgca taacgatatg gtgctgctac cggccagccg 3411601 tctttgttca tgaacaattg gtggactctg acttcgtgtt cttcacccct gcccgggaag 3411661 cgggtgtgga agattaaata ggaacgcccg gttttttcat catagtatgc ggagttgtgg 3411721 cctggtgaga cgtacccggt gcctttttca ttttctgttt caaaagtgta gctgcccatg 3411781 agtttgacgc cgtatggttc gatggaacgg tcgtcgaaga atgtgcctcc cttgccgcgg 3411841 acgtcgagca ttggattgcc ttctgcatca tagtaagggc cgtccggttt cttggagcgg 3411901 gccacacgga tgttgtagcc gcctgttgca tcgagaccgc catatgatag gtataagtag 3411961 tagtattggg tgtctggatt gtagagaaca tacgggcctt cgattctgct gtggttgccg 3412021 ccgagcagtt ttttcccata tccctgtcca ggaagcggga agcccgtttt cggattcatt 3412081 tcaagtatga aaatgccgcc tgagtatgat ccgtacacca tccacagctt gccgtcttta 3412141 tcaaagaagg tatgcgggtc gacgacattc ggatgtttgg ttgcatcata cggtgttcca 3412201 tcgctgcttg tgccttccat tcctgatttc aaaaagatgc ctttgttttt gtatgggcct 3412261 tcgatgttgt cagcaacggc aacacccatg gcggatcttg gcgaatcgcc gcggcaggcg 3412321 ttgtagtaca tgtagtattt gccgtccgcc agctgcgtga cgtcagccgc ccaaagagta 3412381 tcggattgcg cccattcgaa ggtttctttt aattcttcat agacattcgg gataagtggg 3412441 ttgtcattgc ttacgctggt ggtcagctgc tgccattgca tgaggtcatt cgatttagct 3412501 gaagcgagat gagatccaaa aacataaaaa gtgccgtttg tttcaatgat ggaagggtca 3412561 tggacgctga cttctttaaa tataggtttt tgtgcataga cggagtttgg gagggtgaag 3412621 gccatgataa gagctgcaag aaaacataca cggaacaatc ggttgaacat ctaaacaatt 3412681 cgcctctctt ttttattaaa ttttaaacgc ttacatttct ctatgaagat accccggcct 3412741 attaaaacag ccgaatgttt tcatattcat ccagataggt gatttctcac ttcacttaca 3412801 tagtcagact gatgtctgtc tgttttgcgc agaacttgtt gcttgcatat cctctccttc 3412861 atagttcaac tcttttgctg tttctccttc ttgcatcacg tctgtttttc tttcgcgtac 3412921 atgtaataac tgctttgtca ggttttgcat caactgtgat acagccattt cgttgtcggc 3412981 gttttttaag atgatgcctg attgcccgtc aacaccagag tcattcggct ggctctttat 3413041 aaaacgcctt gcgaaaaata cgacttagta aacgcatatt gagagttaga cagcggcgct 3413101 tgcctccttg tctggatatc gtgtgcaatc gctgaaaaaa cctgttctgc tttctgcgtc 3413161 acgctattac aatagcaatc taacttgtta aagactataa aaaaaccttt tgacttctgc 3413221 tgctgaacca attaatataa tactcagtta atagttatca gaatttttag gaattgagtg 3413281 attcatatga cactgcataa agagcgtcgg atcggccggc tgtctgttct cctgctgctg 3413341 aatgaggcgg aagaaagtac gcaggttgag gagctggagc gagacggatg gaaggtctgt 3413401 cttggcaagg taggatcaat ggacgcacat aaagtagtag ccgcaattga aaccgcttcc 3413461 aaaaagagcg gtgtcattca atctgagggt tatcgggagt cacatgcgct ttatcatgcg 3413521 acgatggagg ctttgcatgg cgtgaccaga ggtgaaatgc tgctgggatc gctgcttcgg 3413581 acggtgggat tgaggtttgc cgttttgagg ggaaatcctt atgaaagtga agcggaaggc 3413641 gattggatcg ctgtctcgct ttacggaaca atcggggcgc cgattaaagg tcttgagcat 3413701 gaaacattcg gcgttggaat taatcacata tgaaacagcc catagatctt agacgatagg 3413761 gggctatgcg tgaaaacaga agttcacagc atagctcctt tttgtatggg cgctttacca 3413821 aagtaaagaa aaaggagttg ggcttatggt gactttagac ggttcttcat tgacaacagc 3413881 cgacgtcgct cgtgtgctgt ttgattttga ggaggcagcg gcttctgagg aaagtatgga 3413941 gcgcgtgaaa aaaagcagag cagcagtgga acggattgta cgcgacgaaa agacaatcta 3414001 cggcatcaac accggatttg gcaaattcag cgatgtcctg attcagaaag aagactcggc 3414061 ggcgctgcag ctgaatttaa tcctttctca tgcctgcgga gtcggcgacc cttttcctga 3414121 gtgtgtttcc agggcaatgc tgcttttgcg cgccaatgcg ctgttaaaag gcttttccgg 3414181 tgtacgcgct gagctgatcg agcagttgct tgctttttta aataaacgcg tccatcctgt 3414241 catccctcag caaggatcac ttggcgcaag cggagatctg gcgccgcttt cccacttggc 3414301 gcttgcgctg atcggacaag gagaagtctt ttttgagggg gaaagaatgc cggcaatgac 3414361 aggcttgaaa aaagcaggta ttcaaccggt aacgctgaca tccaaggaag ggcttgcctt 3414421 gattaacggg actcaggcca tgactgcaat gggggtggtc gcctacatcg aagctgagaa 3414481 actagcctat caaacagaac gaattgccag cttaacgatt gaggggttgc agggaattat 3414541 cgatgcattt gacgaggata ttcacttagc ccgcggctat caggagcaga tcgatgtcgc 3414601 agaacgaatt cgcttttatc tatctgacag cggcctgaca acctcccagg gagaactgcg 3414661 ggtacaggat gcctattcat tgcgctgtat tccgcaagta cacggtgcga cttggcagac 3414721 actaggatat gtcaaagaaa aattagagat tgaaatgaac gcagctacag acaatccact 3414781 cattttcaat gacggtgaca aagtgatttc cggcggaaac tttcacggac agccaatcgc 3414841 ctttgccatg gattttctga aaatcgcaat atcagagctt gcgaatatcg cagagcgtag 3414901 gatcgaacga cttgtgaatc cgcagctgaa tgacctgccg ccgttcctga gccctcatcc 3414961 cggtctgcaa tccggtgcaa tgatcatgca gtacgccgcg gcctcactcg tttctgaaaa 3415021 taaaacactg gcccatcctg caagtgtgga ttccattccg tcatccgcca accaagagga 3415081 ccatgtcagc atgggaacca tcgccgctcg gcatgcttat caggtgatcg caaatacaag 3415141 gagagtcatt gcgatcgaag ccatttgcgc attgcaggct gttgaataca gaggcataga 3415201 acatgcagcg tcctatacga aacagctttt tcaagaaatg agaaaagtcg tgccgtccat 3415261 tcagcaggac cgtgtttttt cctatgacat tgaacgcttg actgactggc tgaagaaaga 3415321 atctttaata cctgatcatc agaataaaga actaaggggg atgaacatat gactgatgta 3415381 aaaaaatcaa tccgtgccaa cagaggaaca gagcttgaat gcttaggatg ggagcaagag 3415441 gcagtgcttc ggatgcttcg aaacaacctt gatccagaag tcgccgagaa gccggaggac 3415501 ctcatcgtat atggcgggat tggcaaagcc gcacgggatt gggacgcttt tcacgccatt 3415561 gagcattcct tgaaaacatt aaaaaatgat gaaacattgc tcgtgcaatc cggaaagccc 3415621 gttggcatgt tccgtacaca cccgcaggcc cctcgcgtgc tcctagcaaa ttctgttctt 3415681 gttccgaagt gggcagactg ggagcatttc cacgaacttg agaaaaaagg gttaatgatg 3415741 tacggacaga tgacggctgg cagctggatt tacattggct cacaaggcat attgcaagga 3415801 acctatgaaa ccttcgctga gctggcgcga cagcacttcg ggggcagctt aaaaggaacg 3415861 ttgacgctga cagcgggtct cggcggaatg ggaggcgccc agccgctgtc agtcacgatg 3415921 aatgaaggcg tcgtgattgc cgtcgaggtt gacgagaaac gcatcgacaa gcggatcgaa 3415981 acaaaatact gcgatcgaaa aacagcatcg attgaggaag ccttagcttg ggctgaagag 3416041 gcaaagctgg caggaaaacc tttgtccatt gcacttctcg gaaacgcagc tgaggtgcat 3416101 cacacacttt tgaaccgagg cgtcaaaatt gatattgtga cagatcagac atctgcccat 3416161 gaccctttaa tcggttatgt tcccgagggc tattcccttg atgaagctga ccgtttgcgt 3416221 caagacactc cagagcttta cgtgcgcctt gcgaagcaaa gcatgaaaaa acatgtcgaa 3416281 gccatgctgg cctttcagca aaagggctct attgtatttg actacggcaa caatatccgg 3416341 caagtcgcaa aggatgaagg gctggagaat gccttcgatt ttccggggtt tgtccctgcc 3416401 tacatccgcc ccttattctg tgaaggaaaa gggccgttcc gctgggcggc gctttccgga 3416461 gatccggcag atatttaccg tacggatgcg ttattaaaag agctgttccc gacaaataaa 3416521 gcccttcacc gctggattga tatggcacag gaaaaagtca ccttccaagg cttgccgtcc 3416581 cgtatctgct ggcttggata tggagaacga aaaaagatgg gcctcgccat taacgagctg 3416641 gttagaaccg gggagctaaa agcgcctgtc gttattggga gagatcattt ggactgcggg 3416701 tctgtcgcct ctccaaaccg ggaaacagaa gcgatgaagg atggaagtga cgctgtcggt 3416761 gattgggctg tgctaaatgc gcttgtcaac acggcggcgg gtgcaagctg ggtttccttc 3416821 caccatggcg gcggcgtcgg aatgggctat tcccttcatg ccggcatggt tgcagtggcc 3416881 gatggaagtg agctggctga cgagcggctc gcgcgggtct taacgagcga cccaggaatg 3416941 ggcattatcc gtcatgcgga tgcgggttat gaacgtgccg ttgaagtagc gaaggaacag 3417001 gacattatcg tgccgatgca aaaataaagg agtgatgaca tgccaaagca aattgatacg 3417061 attctcatca acatcggtca gcttttgacg atggaaagca gcggtccgcg ggcaggcaaa 3417121 agcatgcagg atcttcatgt gatcgaagac gctgttgtcg gcatccatga acagaaaatt 3417181 gtgttcgccg gacaaaaagg ggctgaagcc ggttacgagg cagacgaaat cattgactgt 3417241 tcgggacgcc ttgtaacgcc tggcctcgtt gatccgcaca cccatcttgt atttggcgga 3417301 tctcgtgaaa aggagatgaa ccttaagctt cagggcattt catatttgga tattctggcg 3417361 cagggcggcg ggattctgtc tacagtcaag gataccaggg cggcttcaga agaagagctg 3417421 ctgcaaaaag cccattttca tctgcaaaga atgctgtcct acggcacaac cacagcagaa 3417481 gtgaaaagcg gctacggctt ggaaaaagag acagagctca aacagttgcg tgtcgcaaag 3417541 aaactgcatg aaagccagcc tgttgacctt gtttccacat ttatgggagc ccatgcgatt 3417601 cctcccgaat atcaaaacga tccagatgat tttctggatc aaatgctttc ccttttgccg 3417661 gaaatcaaag agcaggagct cgccagcttt gctgatattt ttacagaaac aggcgttttt 3417721 acagtcagcc aatcccgccg ttatttacaa aaagcagctg aggcaggctt cggattaaaa 3417781 atacacgcag atgaaatcga tccgcttgga ggtgctgaat tagcaggtaa gctaaaggcc 3417841 gtctcagccg accatttggt aggtacatcg gacgaaggca taaagaaatt ggctgaggca 3417901 ggaacgatcg ccgtcctctt gccgggcacg acattttatc ttggcaaaag cacatacgcc 3417961 agggcaagag ctatgattga tgaaggtgta tgtgtcagct tggcaacgga ttttaatcct 3418021 ggcagctcgc cgactgaaaa tatccagctg attatgtcca ttgccgcgct tcatctgaaa 3418081 atgactgcag aagaaatatg gcacgcggtc acagtcaatg ccgcatatgc cataggaaaa 3418141 ggagaagaag ccggtcagct caaagctggc cgctcagctg atcttgtcat ttggcaagcc 3418201 ccgaactata tgtatattcc gtatcactac ggggtcaatc atgtacatca agtcatgaaa 3418261 aatggaacaa ttgttgtcaa cagggaggga gccattcttg gataagtacc cttttctcag 3418321 agaggccgga tcttcgttta aagaccggga tgtcacaaaa atgagcgacc tgatcgcaac 3418381 atgggacggc caggacatta agggaccggc gttgataggt gtccccctat caaaatcctc 3418441 catcagtcat tcaggcgctt cctttgcacc cggaacaata cgccaggctc tgaaacattc 3418501 atcagcctat tctgctgagc ttggagagca cgtcgtatca gagcttctat atgacctggg 3418561 ggatatcgat attcatgtca ctgatatcgt aaagtcacat catcacattt tccaaaccat 3418621 gcacgctctg ctttcggatc atccggattg ggtgccgctc atacttgggg gagataactc 3418681 tatcagctac tccacaataa aagcgatagc acaaacaaaa ggaacgacag cggtgattca 3418741 atttgatgcc catcacgatg ttcgcaatac ggaggacggg gggccgacaa acggcacccc 3418801 cttccgccgc cttttggatg aagagatcat tgaaggtcaa catttgatcc agctgggtat 3418861 cagagaattc agcaacagcc aggcctatga agcatatgca aaaaaacata acgtgaacat 3418921 tcacacgatg gacatgatcc gggaaaaagg actaatccca acgataaaag agattttgcc 3418981 tgttgttcaa gataaaacag atttcatttt tatatctgtt gacatggatg tcttagacca 3419041 gtcccatgca cccggctgtc cagcgattgg cccgggcggc ctctatacag acgaattgct 3419101 tgaagcagtc aagtacatcg cacaacagcc caatgttgcc gggattgaaa ttgttgaagt 3419161 cgaccctacc ctcgattttc gagatatgac aagcagagct gcagctcatg ttctgttaca 3419221 cgcattaaaa ggaatgaaac tctccccatt caagtgatct tctggcaggt tgtattttgg 3419281 gtataagaaa ctcatctgcc taaggaatgg cagctaaaag gagggcgaga cagtgaatct 3419341 tcaggagaac agcagccaac agctaaaacg cacaatgaaa agcaggcacc tatttatgat 3419401 ctcattggga ggcgtcatag gcacaggact tttcctcagt acgggctata cgctacatca 3419461 agccggaccc ggcggtacga tactcgctta tgtaatcggc gggttgatga tgtacctcgt 3419521 catgcaatgt ctcggcgaat tgtcggttgc catgccggtg accggctctt ttcaaaaata 3419581 tgctacaaca tttatcggtc catctaccgg ttttatggtc ggcatcatgt actggatcaa 3419641 ttgggtggtg acggtaggct ctgagtttac cgcatccggt attctcatgc agcgctggtt 3419701 ccctgacagc agtgtatgga tgtggagtgc gatttttgca gcccttcttt ttatatgcaa 3419761 cgcattttca gttaagttat ttgcggaaac tgaattttgg ttttccagcg taaagattgt 3419821 caccattatt ttatttatca ttttaggagg agccgccatg tttggcctga tctctttaaa 3419881 cggaacggcg gatgctccta tgttgtcaaa cttcacagat catggcgggt tgtttccaaa 3419941 tggctttctc gccgttttta tcgcgatgat atctgtgagc ttcgcctttt ccggtacaga 3420001 gttaatcggc gttacagcag gagaatcagc aaatcctcaa aaggatatac cgcgatccat 3420061 ccgtaatgtc gcatggagaa ccgtgatttt tttcattggc gctgtcttca tattatccgg 3420121 gttgatttca tggaaggacg caggcgtgat tgaaagcccg tttgtcgccg tatttgcgga 3420181 gatcggaatt ccttacgctg ctgatattat gaatttcgta atattaacag ccttgctgtc 3420241 tgtcgccaac tcaggcttat atgcttcgac ccgtatgatg tggtctttag caaatgaaaa 3420301 catgatcagc tcccgtttta agaaagtgac atctaaaggc attcctttaa atgccttaat 3420361 gatcagtatg gctgtatctt gtttatctct cgtttccagt atcgtggccc ctggaactgt 3420421 ctatgtggtg atggtcgcaa ttgctggatt tgcaggagtc gtggtctgga tgagcattgc 3420481 cttgtcccaa ctcttgtttc gaaagagatt tttgaaaaaa gggggggatg taaaagatct 3420541 gacatttcgc acgccgcttt atcctcttat gcctatagcc gctctcttat tatgttctgc 3420601 ttcttgtatc ggtcttgctt ttgatcccaa tcaaagaatc gcacttttct gcggagttcc 3420661 ttgtatcatc ctttgctatc tcatctacca tttcaaaaga aatgttacaa aagcgaaaaa 3420721 aatcagccaa gaggaatatc cagccgatca catcctataa ttaaaaaagc acaccccgct 3420781 cagcatggga tgtgctttat tttttattct gtaattaacg tatgaatcag cttcggcgcc 3420841 ttcgcttccg cggcgatgcg gatgttgtca tagacttttg cgatgacttc atcgacgttt 3420901 tctcggttag cgtaaagcgt tacgagcggt tccccttttt ctactttgtc gccgaccttt 3420961 ttgcggagca tgatgccgac ggctaaatcg atttcgtctt cttttgtggc gcggccggca 3421021 cctaacagca tcgccgcgac gccgatttcg tccgcgacga tttcagagac gacacccgct 3421081 tctttggcag gcacatcaat ttgatatgcg gcttgcggaa gcttagacgg atcgtcaaca 3421141 attgagctgt cgccgccttg gtttttcagg aaatccttga atttctcaag tgctttgccg 3421201 tttttcatga cttcttccag cttcgctctc gcttcgtcca atgtatcggc ttttttcgca 3421261 agcacaacca tctggctgcc gagcgttaag acaagctcat gaagatcctc aggcccctcg 3421321 cctttgagcg tgtcgatcgc ttctttgact tcaagcgcat ttccgatcgc aaagccgagt 3421381 ggctgggaca tgtctgaaat gacagccatt gtttgacggc cgacgttatt tccgatgcgt 3421441 accatcgctt tggcaagttc agctgcgtct tcttctgttt tcatgaaggc gcccgctccc 3421501 gtttttacgt caagcacgat ggcgtccgcc ccggcagcga tttttttgct cataatcgag 3421561 cttgcaatga gcggaatgga attgaccgtt cccgttacat cacgaagcgc gtacagtttt 3421621 ttatcagccg gcgttaaatt gccgctttgg ccgatgaccg caaccttgtc gcggttcaca 3421681 agtttaataa attcatcctt cgtcagttcc acgtggaagc ccatgattgc ctctaactta 3421741 tcaatcgtgc cgcccgtatg gccgaggccg cggccggaca tcttagcaac cggcacatca 3421801 agagccgcaa caagcggagc gagaacgagc gttgtcgtgt cgccgacgcc gccggtagag 3421861 tgtttatcca ctttaattcc ttcaatggca gaaagatcaa tcgtttcacc ggagttcacc 3421921 atagccatcg tcaagtccgc gcgttcacgg tcactcatat cctggaagaa aatcgccata 3421981 gcaagcgcgc ttgcctgata atcaggaatg cttccatctg tatagccgtt cacaaaaaat 3422041 tgaatttctt cagtggtgag ttcttttccg ttttgttttt tgatgatgat atctaccatt 3422101 ctcatgtttg gtcaccgatc cttttcgatt aagttcagta aatcaagccc acaattgctg 3422161 ctgataaaaa gctgacaagc gtagcaccgt ataataattt caagccgaaa cgagcgacga 3422221 catttccttg cttttcattc agtcctttta cggcaccggc aatgattccg attgaggaga 3422281 agttcgcaaa tgacacaagg aataccgata cgatcgctgt tgtacggccg ctgaaatgga 3422341 aaccgttttg cgtaagcgac gtcatggcga caaattcatt cgataccatt tttgttgcca 3422401 taatgcttcc cgcattaaca gcttcattcc atgggatacc gacaagaaaa gcgaatggag 3422461 caaacacata tccaagaatg ccttggaacg aaataccgaa tactgcatta aaaatgccat 3422521 tgatcaatgc aataatcgcg acaaatccaa tcagcatcgc agcgacgaca accgctactt 3422581 tgaaaccgtc aagaatgtat tctccgagca cttcgaagaa ggattgtttt tcttcttcct 3422641 caacacgaag catatcctct tcttttgcaa cctcgtacgg attgataata gaagcgataa 3422701 tgaaaccgcc aaataagttc aaaacaagcg ctgttacaac atattccggt ttcagcattg 3422761 tcatatacgc accgacaatc gacattgata cagttgacat cgcagatgcg caaagcgtgt 3422821 acaagcgctg ctgatttaaa agaccgagtt ctttcttcaa ggagataaat acttctgact 3422881 gccctaaaat cgcagaagcc actgcgttat acgattccaa tcttcccata ccgtttacct 3422941 tgctgagggc aaggccgata tatctaatga taaacgggag gactttccac ttttgcagaa 3423001 tcccgatcag agcggaaata aacacgattg gcaagagaac attcataaag aatgtcgttt 3423061 ggtccgcatt caccaagccg ccaaacacaa agttaattcc ctctgccgcg tattcaagca 3423121 ggtaaccgaa tccttttgca aatcctccca cgaggaaatt ccctattccg gtattgagga 3423181 gaatgtagcc aagaataaat tgcaaaatga gcataacaac aattgggcgg atcttaattc 3423241 tttttttgcc gctgctcgcg atccacgcga ggcctaaaaa cacgattaaa ccgataatcc 3423301 caatcaaata cttcatatgt gtttctcctt tatttgtatt cgcttacaat tactgtttcc 3423361 tcagaaaacg gaaagcagtc tgccttccgt cagctcttaa tagttgtctc cgcctgatgc 3423421 attttctcct tttacgatag aaacgcctgc gctggcgcca attcggcttg ctccggcctc 3423481 taccattgtg tctacatctt ctttcgttct gacgccgcca gatgctttca cgccgatatc 3423541 aggccctact gttttgcgca ttaaggcgat atcttccttc gttgcgccgc ctgtagaaaa 3423601 gcctgttgat gtttttacga aatccgctcc cgcagacacc gctaaacggc atgcacgttc 3423661 tttttcttca tcagtcagaa ggcacgtttc gataatgact ttgacaagcg cttttccggc 3423721 tacagcttcc actacaccgc ggatatcagc ttccaccaca tcgtcttcct tgtcttttaa 3423781 agcggcaata ttaatgacca tatccacttc agtggcgcct tttgaaatgg cgtcttttgt 3423841 ttcgaacgct tttgtttcag ttgtattggc accgagcggg aagccgatga ccgtacaaac 3423901 gtcgactcca gttcccttaa gctcttttgc agcaagctcc acccatgtcg gattgacaca 3423961 tactgaagca aatttgtatg ttttcgcttc ttcaattagt tttagaatgt ccgctttttg 3424021 tgtatgcggt ttcaaagctg tatgatcaat tatgttggct aatgacatcc ttcgcacact 3424081 tccttttttg ttaagatatt ttttagcata accgactttt gaacatatgt aaattggtaa 3424141 ttgaaatttt gttcaatgaa aggtttgaac gtgtcacaaa tcattaacaa gcgccctcgc 3424201 ggtatgctgg tcaatgatta aaacgttggc atattttccg gttaatgctc cgtgaatgga 3424261 agatactttt ctgcttccgc cggcaactaa aatggagcgt tccttcagtc taaggtcttg 3424321 aagctcaaca ccgatggtcc ggtcattgat ggcgctgctg caaatattcc ctttcgcatc 3424381 aaaaaagcgt gaacaaatat ccccgacggc ctgttttttc agcagggctt tctcttcttc 3424441 gttaaaatat ccgagccgaa acaacagcgc ttcatcacgg acagtcccga ccgtaaagag 3424501 agcgatattc gcctgcttgc ccatctcaat gatccgttca atatgacggt ctttctccac 3424561 cattcgcttc acatccgcat tatcaaacac gacgggaagc gggagatagc gcggcatcgt 3424621 ttgaaaagcc tctgcaaaca gctgaatcgt ttcagccgaa tacgtgttta cccgggaatg 3424681 gctgatgccg cctttcagct ggacgacctc gacgcctttt acctgcttcg gctgcatgtt 3424741 ttgcgcgatt tgatacatgg tggttcccca gctgacgccg acaatgtcgc cgtcttttac 3424801 cgtttcatgc atatattctg caccatagcg gcttaggtca tgtgtaattc ctgcataatc 3424861 gggtgtcggg gaaaacacaa catgcgcctc aaggagcccg tatttctctt caagtatgga 3424921 accgagcgca tccaaatcct caaaagggtc catgacgcga atctggacat accctttttc 3424981 ctttgcatat tgcagcagcc gggaaacggt tggccttgaa atgttgagct gctcagcaat 3425041 ttgctgctga ctgtagtcag actgatagta aagccttgcc gcttctatgc ttaattgctg 3425101 tttttcccga tccattctgc acctccctgt ggatcagtcc tgataaaact gcttttgatt 3425161 tgcttttatt atacaggctg gcgccggctt tcatccacct gatttctaag aaactgaaaa 3425221 acgctctggg cgcggacctg cccagagctt acttctccca agtcggtttc tctgagcata 3425281 aagttatttc gtttttccta aactcagcgg atctgtgatc atctcttttg gctataaagt 3425341 ttccgttttt tcaaaacaaa tgtttcaaat gagataggaa atgggtacta atctattaac 3425401 tttgttacat atttttagat actcattggc tcaacaactg aggaggagac atttgtgaag 3425461 aaagacacaa ggaaatatat gatctacttt ttcggcgctt tagggggact gctatatggt 3425521 tacgatacag gtgttatctc cggagcactc ctgtttatca ataacgatat tcctttaacg 3425581 acattgacag aaggattggt tgtcagcatg ctgctccttg gcgcgatttt cggttctgcc 3425641 ttgagcggca catgctcaga ccgctggggc aggagaaagg ttgtatttgt cctttccatc 3425701 atttttatta tcggtgcgct cgcttgcgca ttttctcaaa caatcggcat gctgattgca 3425761 tctagggtga tactcgggtt ggccgtcggc ggttcaacgg cacttgtgcc cgtgtatctt 3425821 tccgaaatgg caccgacgaa aattcgcggg acactcggca caatgaacaa cttaatgatt 3425881 gtcaccggga ttttgctcgc ctatatcgtt aactacctgt tcacaccgtt tgaagcgtgg 3425941 cgctggatgg tcggtctggc tgcagtgcct gccgtgcttc tattaatcgg catcgccttc 3426001 atgccggaat cgccaagatg gctcgtgaag cgcggcagcg aagaagaagc gagacgcatc 3426061 atgaacatca ctcatgaccc caaagacatc gaaatggaat tggcagagat gaagcaaggg 3426121 gaagcggaga aaaaagaaac gacacttggc gtgctgaaag ccaagtggat tcgccctatg 3426181 cttctgattg gcgtcggcct tgccattttc cagcaggcag tcggcattaa cacggtcatc 3426241 tactacgcgc caaccatttt tacgaaggcc ggtcttggca catcagcttc ggcgctcggc 3426301 acaatgggaa tcggcatcct caacgtcatc atgtgtatca ctgccatgat cttaattgac 3426361 cgtgtcggcc gcaaaaaact tctgatctgg ggaagtgtcg gcatcacact gagccttgct 3426421 gctttatcag gcgtgctcct gacactgggg ctttccgcat caacagcgtg gatgacagta 3426481 gtctttctcg gtgtctatat cgtcttttac caggcgacat ggggtccggt agtgtgggtg 3426541 ctcatgcctg agctcttccc gtccaaagca cgcggagccg cgacagggtt cacgactttg 3426601 gtgttatcgg cggctaacct gatcgtgtcg cttgtcttcc cgctgatgct aagcgcgatg 3426661 ggcatcgcat gggtctttat ggttttctca gtcatttgtc ttctctcatt tttcttcgcg 3426721 ttctacatgg taccggaaac caaagggaaa agcttggagg aaattgaagc aagcctgaaa 3426781 aaacggttta aaaagaagaa aagcacccaa aaccaagtgc tgaatgagcg tacattataa 3426841 aaaaaggaat cgtctcctta tgagacgatt cctttttctg tttacaccat gaccttgcaa 3426901 atattgttcg taaattccac agggtcctga atcggcaggc cttcgatgag gagcgcctga 3426961 ttgtacagaa ggtttgtgta caggctcagc ttctctttat cttgttcaaa cgcgtcctgc 3427021 agtgtttgga atacctcgtg atttgggttg atttccagca ctttttccgc cttcacattt 3427081 tggctgtcag gcatcgcatt taagattttt tccatctcaa ttgtcacttc gccgtcagca 3427141 gcaaggcaga ctggatgtga tttaagccgt tttgagattc tgacgttttt cactttgtct 3427201 gacagaatgt ttttcatttc ctcaaacaga tccttatact tgctttcctc ttcctcggac 3427261 tgcttttgat cctcatccgt gtctatgcca aggtctccgc ttgatacgga cttgaattct 3427321 ttttcctgat aagaagccag cattttaatt gcaaactcat cgatgtcctc agtaaagtag 3427381 aggatttcat agcctttgtc cgccaccatt tccgtttgcg gcagtttctc aatgcggtcg 3427441 taagaatcac cggtcgcgta ataaatgaat ttctgctcct ctggcattct ggaaacatac 3427501 tcgtctaagc tgaccagttt tttctctttt gaagagtaga ataagaggag atccttcaat 3427561 tgatccttat tcgcgccaaa atcattgtac acgccgaatt tcagctgtct gccgaacgac 3427621 ttgtagaacg tctcgtattt ctcgcggtct tttttcaaca ggctttgcag ctcgcttttg 3427681 attttcttgc tgatgttttt cgcgatcagc ttcagctggc ggtcatgctg cagcatttct 3427741 ctggaaatat tcagcgacag atcctcagaa tcgaccatgc ccttcacaaa gctgaagtgg 3427801 tccggtagca ggtctgcgca cttattcatg atcagcacgc cattggaata cagctccaag 3427861 cctttctcat attccttgga atagtagtca aacggcatgt tttcagggac gaatagaatc 3427921 gcgttgtagc gaaccgctcc atccacgctg atatgaacgt gtgtcagcgg tttatcaaac 3427981 ccgtaatgct tttcagcata gaatttttca taatcctcat ctgtcagctc gcttttgttt 3428041 tttctccaga tcggcaccat gctgttgacc gtctgctctt cctgcacctc ttcaaattca 3428101 ttttcgctgc cttccttcgg cttattaatg gttgtatcca ttttgatcgg gtagcgaatg 3428161 aagtcggagt acttcttgat gatcgctttt aaacgatatt cctctaaaaa ctcgtcatag 3428221 ctgtcatctt ctgtgttctc tttgattttc aggataatgt ctgtaccgac agaatccttt 3428281 tcacacggct caatcgtata gccgtctgca cccgcagact cccatttata agcctcttcg 3428341 ctgccaagcg ctttactgat gactgtcacg acatcggcaa ccataaatgc cgcgtaaaaa 3428401 ccgacaccga actgcccgat aatgtcatgt ccgtctttca gctcgttttc ctttttaaac 3428461 gcgagggaac cgctttttgc aattgttcca agatgctgtt caagctcatc ctttgtcatt 3428521 ccgatccccg tatcagagat ggttaatgtt ctcgcatctt tgtcagctgc gacctttatg 3428581 tagtaactgt ctttatcaaa cgtaagcgca tcgtccgtaa gcgctttgta atagattttg 3428641 tcaatcgcat cactcgaatt ggagattaac tcgcgcagga aaatttcttt ttgggtataa 3428701 atggagttaa tcatcatatc cagcaagcgt ttagactctg ctttaaactc ttttttcgcc 3428761 actcttgatc gctcctttac cattatgtaa acccttttca gcatctattt atcacataag 3428821 atgacaattg tcaattagat tgatagatgc atatatatgt aaatttaaca ttagttggat 3428881 ttgttttcac tctttttctc actcattctc ataaaaaaga gaggcttcat catcctctct 3428941 ttttttctgt gtcattccaa cggccaaact cccgcttcat ccatatatgc accgggtaga 3429001 aaaacaaacc gaacggtatc aaaaacaaaa gattatgcca tgaagcattc agaaatgcgc 3429061 ttgcagtcac cgggaacgta atctcttgca ataaaaaaga gatgacagtc agcacaacaa 3429121 atgcagatgg aatggtcacg atgcaataaa acttgagctc cttcttatgc tgtaccttca 3429181 aacatacaaa cctcccaaca atttctaatt catcttaaca tatgctggcc tttcttttct 3429241 cgcatgttta tcactgcaca tagcgggaag acaaatagaa aaaggaggtc tcgtatcatg 3429301 ggaagacttg aaaacaaaac agcagttatc acaggcgccg cgacaggcat tggtcaagcg 3429361 acggcggagg tttttgccaa tgaaggcgcg cgtgtgatca tcggagatat caataaagat 3429421 caaatggaag aaacagttga cgcaatcaga aaaaacggag gacaggccga atcctttcac 3429481 ctcgatgtgt cagatgaaaa cagtgtgaaa gcatttgctg atcaaatcaa ggatgcatgc 3429541 ggaacgattg atattctgtt taataatgcc ggcgttgatc aggaaggcgg aaaggtgcac 3429601 gaatatccgg ttgacctgtt tgaccgcatt atcgccgtcg acctgcgcgg cacattcctt 3429661 tgcagcaaat atttgattcc gctcatgctc gaaaatggag gctccatcat caacacctcc 3429721 tccatgtcag gccgtgccgc ggaccttgac cgctccggct acaacgccgc aaaaggcggt 3429781 atcaccaacc tgacaaaggc aatggcaatc gactacgcac gaaacggcat ccgcgtcaat 3429841 tccatttcac cgggcacgat cgaaacaccg ctgattgaca aattagcagg cacaaaagaa 3429901 caggaaatgg gcgaacaatt ccgcgaagcc aacaaatgga tcacgccgct cggacgtctt 3429961 ggccagccca aagaaatggc aacagtggca ctgttcctcg catcagacga cagctcatac 3430021 gtcacaggag aagacatcac cgcagacggc ggcatcatgg cgtacacatg gcctgggaag 3430081 atgctgattg aggagaaatg gaaggaagaa acgaaataag agagggagcc ccctctcttt 3430141 ttgtctttta aagcaataca accttatatt tcttcacatc caaaaactgc aaaaactccc 3430201 tcgccagcac ttcaggcgga tgcgcctttc cttcatccag ccgatacaaa agcaacccga 3430261 taatcattgc ggatacataa tgggcataaa gctttttctc tgcgtgaata tcagtttgct 3430321 gatgcagata aaacgattcc agcgctttga acatatcagg tatcacatga ggaacacccc 3430381 attcccgatt gagaaaatgg acaatgggca tgtttgacaa agcagaaagc agaatggcga 3430441 gcgccttctc cgcttccttt aaggaaaatt cattcgggct ggaggcaatc gtcaggtgat 3430501 caatgatctc cgcacatgat cgctgtatca tggtttggag caattcctcc ttattggcat 3430561 agtgatcata aaaggttgca cggcggatat tgcttttacg cgtaatatct gaaatcgtga 3430621 tgcccgcgta gtcttgtttc tccgccaata catccagaaa tgccttctgc agcgcctctc 3430681 tcgttcgaac cacccgcctg tcgatttgct tctccttctc tcgctctcct ggcacagctt 3430741 ttccaaacag ccaataaaac cgcttttgag aaacaagctc ccataccttc tggctgatgg 3430801 cttcaggaga cgcggccgca tcctcattca gccaatacag gataatcgcg tacgtgtaca 3430861 aggcccgata atgtccataa atgtcccgtt caatcggcgt taaattcaca tggatcggag 3430921 ccagcagcac atcctgctga aacacatcct taaaaaaacg atgaaaatgt cctctgttca 3430981 tcatcacaga aaaaaaggaa cgatgctcat gaacaaagga cagcgtcgga tgcaccgttt 3431041 gccgtttttt gttcaaatga agggtatcca tatgactgaa ggcgtcaaaa agcgctttgc 3431101 ccagtccttc cttcatgtct tcgatcacat cctcaatgat tgaaaactta tcctcataat 3431161 aaaggtagag cgatccgcgg ctcactttgg ccttctcagc gatttctttc attgtgatgt 3431221 gttgaatatc tctatctttc aataaagcca gcagcgcctc tttcacttga gcttcggcag 3431281 attccggcac aaaagacacc tccaatcatt agacagatct tagatatatg tacggtaacg 3431341 tatagatggt tcaccgttgt ctttcttaca gaaaaggtac caccttataa taggtccgag 3431401 aaaagaagaa agcaaatgag ggggatttta caatggaaca gcaagtaaag gacgacatcc 3431461 agcgtgtctt tcagcttcag aaaaaacagc aaaaagcctt gcgcgcttca acagcggaac 3431521 agcggagaga aaagcttcaa cgctttttag attccgtcat cgcccatgaa gaagaaatca 3431581 tcgaagcgat ccgcaaagac gtccgcaaac catatcacga agtcaaaaaa gcggaaatcg 3431641 aaggaacaaa aaaagcgatt agagataata tgaataacct ggaacaatgg atggcgccta 3431701 aagaagtcgg ttcatcgtta agccctgacg caaacggaat tcttatgtac gagcctaaag 3431761 gcgtcacact catcctcggc ccgtggaact atccgtttat gctgacgatg gcgccgcttg 3431821 ccgcttctct cgcagccgga aacagcgcga ttgtgaagct gtccgatttc acgatgaaca 3431881 cgagcaacat tgctgctaaa gtaataagag acgcttttga tgaaaaagaa gtcgcgattt 3431941 ttgaaggaga ggttgaggtg gcaaccgaac tacttgatca gccgttcgac catattttct 3432001 tcactggaag cacaaatgtc gggaaaattg tcatgacagc ggctgccaaa cacttggcat 3432061 ctgtcacact tgagcttggc ggcaagagcc cgacgatcat tgacagtgaa tacgatctga 3432121 tggacgcagc gaaaaagatc gccgtcggga aattcgtaaa cgccggccaa acctgcatcg 3432181 cacctgatta cctgttcatt aaaaaagacg ttcaggacag gttcgcgggg attttacaaa 3432241 cagtcgtcaa cgctggattt atggaggatg atcatacccc agaccgcagc aaatttacgc 3432301 agatcgtcaa tgaccgcaac ttcaaccgcg tcaaagatct gttcgacgat gccatcgaaa 3432361 gaggggcgga agtggtgttc ggcggcgtat tcgatgccag cgaccgcacg atctcgccaa 3432421 ccgttttgaa aaacgtcacg cctgacatga aaatcatgca ggaggaaatc ttcgcatcga 3432481 tcctgccaat gatgaactat gaagacatcg acgaggtcat cgattacgta aatgaccgcg 3432541 ataaaccgct tgcactttat gtgttcagca aaaaccaaga tctgattgac aacgtccttc 3432601 agcacacgac atcaggaaat gccgccatca atgatgtcgt cgtccatttc agtgacgtca 3432661 acctgccatt cggcggcgtc aacacaagcg gaatcggctc ctatcatggg gtatacggat 3432721 tcaaagagtt ttctcatgag aagggtgtat ttattcaggc cgctgaataa tcgcatgatc 3432781 aaaaggcgct tccttagagg agcgcctttt attgtaactc cttgaccaaa agcaattcat 3432841 cacggatagg tattttatta tctgccagta aaggaatttc gggcttcatc tttctggccg 3432901 tctcgactgc attcacaaat agtcgatcca accggtaccc tctcttctga taaaacgcta 3432961 atgcatgaat attatcattg gttgtgatca gttttatttg tttgatattt ctctctctgc 3433021 atgcttcctc ggctttctct agcagagctg ttccgatccc tttattctca atgacactat 3433081 ccagcgaaat gatttcacag gcatcttctt caaatatgta tgtaataagg ccaacaatct 3433141 ggttatcatc gttgagcatt ccataaccat ctaattcatc gcagttataa ataccgctag 3433201 aaataaccat ttgcggactg ccccagtgtt tttgaaaaaa cgcggaaaca agatctttag 3433261 gtacctggca tgtcggaata atattcatat tttcctcctt ttagctgaac aaaaataaga 3433321 gaattaacaa cctattttat gtcattaatc cccttatcta gtatttacta gaacttataa 3433381 cttgtcaaaa gctgtctgaa taccaattgc gtggattgat aaggatcaaa atctgaatcc 3433441 tgagattgga agatttgctc tggggtcaat gtctctgcgt tctctgataa cgtttgaatc 3433501 agactttcca aatatccatt taactctgat ttggacgatt catgtaggga ttgatgattt 3433561 acagcgagtt ctctaaatct gttatcactg attaattttt ttcgaagagc tgctagcatc 3433621 aagtcaagcc atgcaggctg gccaaatgta atatttaaag ctaacgttgc ttgatcagat 3433681 ttggtggagt gccataaacc tcttggcaaa tacagcatgg ttcccggtgt taaattaacg 3433741 atttctgcat ctggcagatc ctcttttggc ggatctcctt tccaatatga ctgtaaatca 3433801 tcaggatagt aaggagcctc tgataaatca tagtgctgca ttggattgct cacattttca 3433861 ttcttggcaa gcttccatgt tttctcacct tgaatttgaa aaatcaagtt ggtgtaggcg 3433921 tcaaaatggg ctttgaatcc cccgccattt ttcgccgcgt aaacaatggc tttggaagaa 3433981 gtacccgcag gcagtcttaa ttccgctttg agtttttcta tccaccttct gacttgggga 3434041 ataaataggt cggtgaaatc aaactctaat gcagcccctt tttcatacca ctctaaagcc 3434101 tctgcaggtg acacaagaaa tctgtctgtg atcccttcag attcttcaat cacagcatca 3434161 ccaacgacca tgactggatt attgtagata gccaatacgt tttctagcgt tctaaccttt 3434221 tcaaaccccg gtatgcttgt aaatctctcc acttctcctc tggctaccaa aggttttaca 3434281 ggccaatatt cttctaaaaa ctcactcatc gttacaggac tgatgataga ctccaaaacc 3434341 gattcggtta cagcactcat attatccctc ccaaaaaaag taacttcacc acaaagatat 3434401 aacatttttt tctaaaagta aatattgaca gaattatcag aggattataa tatttagttg 3434461 tgcgtgatag cctatttttt tacaaggaag gagggaaaag gatgaaaaag gcttataaga 3434521 aacctcgtct ttttgaactg cgccgtgctg tagcagctgg cggccattaa tctcatatag 3434581 catttgacat ctagtactct attttaggag ggatgctcaa tgaaaaaagc ttataagaaa 3434641 cctcgccttt ttgaactgcg ccgtgctgta gcagctggcg gccattaatc tcatatagca 3434701 tttgacatct agtactctat tttaggaggg atgctcaatg aaaaaagctt ataagaaacc 3434761 tcgccttttt gaattgcgcc gcgctgtagc agctggcggt cattaatctt atccaaaacg 3434821 attaacgttt gaggctatca cgccaacttg ataaggagga tgctgaagat gattacggct 3434881 gaagaatgca gaacgtacaa agaatttgtt gatctttacc aatcctatct ttaccccttg 3434941 cttggcgcca gactgtcccg gatgtattcc cccaaaaaca aagtcattat cgatatgggc 3435001 acaggtccag gttatttaag cattcagttg gctaaaagaa caaatgcgca cgtgcatgct 3435061 gtcgatatta acccggccat gcatgaaatc gctcaagaag aagctaaaaa aagcggagta 3435121 agcagcctga tttcatttga tttggaagat gtccaccatt tatcttacgc tgaccaatat 3435181 gctgacttca tcgtctccta ctcttgcctg catcattggg aagacgttgt taaaggactt 3435241 aaagagtgct atagagttct ggctccgggc ggaaaaattg tcattttgga tacatttaat 3435301 ccccaaggaa gccatttaga gattatgcga aaacaaatca aagaaccgga atacttcagg 3435361 tttgtaagag aggcatttga agaaagttat tcctttgaag acattcacca gtttgttcag 3435421 gatgccggca ttcccaatta ttcattagaa acctttcact ttttaccgga ggattttata 3435481 gaaagcttag atgagctgga ggatgctccc ctgtgggaac aaaatgatca aagtactgat 3435541 catgaaattg agtctgtcac atggatgtta acgatagaaa aagaaaagga aggtgcattg 3435601 taatgatcaa tgaatcaact gttttatcca aaaatccaga aatgccatca agaaaatatt 3435661 tgaaaagcat tattatagag ccgggcatca ctttaaatga aatggcatca gatatttata 3435721 accatatcga cggcaaggtc agcatacatg atatttgctc aaaaatcgtc aatgaatatg 3435781 atgttgatta tcaaacctgc ttagaagatt gtatggagct gtttgagttg cttattgatc 3435841 atgaagcaat caaagttaag cagggggcat gagaattgga aaaacaaaaa gtgcttgctt 3435901 taccagacga tgtacatgag ctgagtacac accgttctaa atcaatcgta aattacatca 3435961 tcactctgct tgcctttgcc aaaaaacaag gattgactca tcaagatatt gtaagctgga 3436021 ttcacgagca atatgaggaa agaggatatt atgatgagtg gagacacatt aacagccaac 3436081 aaccagttgg atcatttgtg gaactcttta taaaaggaag acgtttactt tatgacaaaa 3436141 ttgaattgtt tgaaacagaa gataaatatg tcgtaaatac ccacacttgg tatgaaaaag 3436201 aacctagtga ggcctttttt tattttgaaa ttgatcccga agaattttct gcgtacgctt 3436261 ccattctcgc aatcgaaaac gcaaaacgtc tcggaattaa aatcgatatt gtaaaagaaa 3436321 cagatgtaga gacagcttat atctataaac atcaataacg ctattgggag ggagacatat 3436381 gtgcgggctc gcgggtatta taaatctggc tgctccccgt tctcaggaat gtacctttca 3436441 tatattgaaa ggcatggcag atgccatcag ctatagggga ccggatgatg aacaatatca 3436501 tattgattcc aaagtcggct ttgcatttcg gcgattgtcc attcttgacc ttgtaaatgg 3436561 acagcagccc tttttaaatg aggatggatc aatcgtcgtt atggtaaatg gagaaattta 3436621 taactataaa gaactgaagg cttctttaca caatcatatg tttaaaacga catctgattg 3436681 tgaagtaatt gttcatttat atgaagaaaa agggattgga tttgtagacg acatcatcgg 3436741 aatgttttca atagccattt gggacaaaaa taaaaacaaa gtatttttag ttcgtgaccg 3436801 ctttgggatt aaaccgcttt tttacacaga gctaaaacac gagcttatat ttgcctctga 3436861 aataaaatcc ctattttctc atcctcactg tccccgccaa tttaattgga aagaagcact 3436921 ctcagacatt tggctaagcg gggaagcagc cagtaatcat aaagaaacca cttccttttt 3436981 tgtaaacatc caaaatctcg atgctggcca ttatctcgaa attaatttga caacaaatga 3437041 acgaaaaaca gcaagctatt ggtctttaca ggatattttg ctcaggcaag gctatcgtga 3437101 gaatctccat cccgatgacc tgattgaagg atatagagaa ctgctggcag attcagtcca 3437161 tagatgttta caaagcgacg ttgaagtcgg gttgtttctt agcggtggca ttgattcagc 3437221 tgcagtcgca cattttgctg cagaaaaaca ggatctccat acgtttacag tattaagcca 3437281 aagtacattt acaaatgaag atgcaaaata tgcccattgg ctggctaaag atttacacct 3437341 tccaaatcat caggttctct atcaattagg gaacgatgag ttattacaac cagagtcata 3437401 taaacatttg ttatggatct gtgaaacacc gttttgcgga ccggaacaat tatataagtt 3437461 tcatttacat aagtatgcca aagcgataag gccaaacctg aaagtcatgc tgaccggcca 3437521 gggcagcgac gaatttaacg gcggttacag cacgacactt tcaccagccg agaacccaag 3437581 ttgggaagga tttattgaat cggtcaatac gatggagatg aaccggctgc atcggctgca 3437641 gggaaatatc tttagagtgt gggaggagca ttttggactt tctcctataa acctttctta 3437701 tttaaagagc aatgattcca gccaagcaga tccttggcaa tcgtatgtcc tgacaaaata 3437761 ccgtgatctg caaatgtata attgctggca tgaagatcgg atcgccgcgg ctaatcatat 3437821 cgaaaaccgt gtaccgttct tggaccatcg gcttgttgaa tgggtttgcg gaatacctga 3437881 tggactccgt aaagacttgt tatgggataa gtcggtattg cgaaaatcat taacaaatga 3437941 gctgcataca agctataccc accggccaaa ggttcctttt ttctatggta aggacgtgag 3438001 atatacacat aaaatgatgt ttcatcttct gaagaaaaac aattatcagc ttatagagga 3438061 ggccttctct cacagcgatg cctccagcat aatacaggtt gaacacattc atgccatcat 3438121 gacatatttg gaggatgatc ctgagtttac aaattttgaa tttttattaa gactggtgaa 3438181 catgggactt ttatcaaaaa tgactaaaga aaccccttct gttcaattag acataaccag 3438241 ccatttagaa tcgataacaa taaaagactg gcactcacag gaaggtgata ttgccagtcg 3438301 tttaaatatc tcagccaata agtgtgaagg acaagatatt ttggcgctaa accctggcgt 3438361 cactctgtta aggccggaaa gcgatagtga gcattgcatc tacattgcgg aagaaggatt 3438421 tattcagttt attgtttcgg aggaagacgt cggagcttgg ctgcatattc tctgcgatat 3438481 taatggaaaa gacacacttc atacgatttt agacagacat ggtgtcagcc ttgaagaagt 3438541 ggccaaatat attcaagaag ccatcgaaca caatatcatt ttgatcaaac aaaaaaatct 3438601 gccagaagga gcatatagat gagcatcttt tattcgtttt ccgcacttag gggattagca 3438661 atggggattt tttcgcctat ttggattctt tatctgatat ctaaagatta tgatttcctt 3438721 cagattggat taatgggagc ggtacttgaa attgctaagc ttatatttga agttccttcc 3438781 ggcgtttttg ctgatcgtta tggaattaaa atttcaattg ccagttcatt ctttttctcc 3438841 atccttacat gggccttctt cccttttatc gattcagctg ctatttgcat actggctatg 3438901 atcatatggg ctttatcaga ttccttaatt tccggttctt ttgaaacttg gatgagccgt 3438961 gtcgcagggg aagatcgatt cggcaaagaa atgatgaaaa acacacaatt gctaatcact 3439021 tttttaatta ttggaagtat tgccagcggg tatttgtatt cattaaatat ctattttcct 3439081 ttcctgctcg ttatggtgat ctacttatta ctatttattt ggatgtctgt atttattaaa 3439141 gtcccttctg tttccgaaac aaatcatggg gatcagaacc aacatgattc gataaagatt 3439201 atcaaagaaa gtttaaaaat tatctttaac aaaaaaaggg ttcttttaat cgtcatagcc 3439261 ggtttcttta cagccacagc ctatgacaca atttcccgtt actggcagcc ttttttgagt 3439321 gatttaggct tttcagaaaa gtcactggga tatatttttg ccctaggagg gtttaccgct 3439381 ctcgttcttt tgacattaac catcaggttc gaaaagaaga tcgaaaaaaa tccatatctc 3439441 gctttaacct cattggattc catgggcatg gtcatgactt ttctattgtc tagagcattc 3439501 aggccgctgg gcattccatg tacagcgttt ttgcttgcaa ttgaagatat tcatcatccg 3439561 atcgtaacaa gttacttaaa taagtttttc cccgattcat acaagaacac acttttctcg 3439621 ttaaactcag gggtaggagc aattggagaa attctttccg gtgtcatttt cggcatcatt 3439681 tccgcagcct ttgggctctc tgccatgttt gttgttgtag ctgtatttct attaatccct 3439741 attatccttt atacgatagt gcctaagatt aaagacaatg atatgaaagt tcagattgaa 3439801 aaatcccagc aagtgtaaat gttttgtatc acagtaagaa gaccttctta ttaaaagaag 3439861 gtcttctgct attctattca gttatttccc aaaagccatc agcttcgtat aacttccaat 3439921 ataaagtgtt ccgtcctcag cgagctgagg agaagacacg acgttgctgt cggtttgata 3439981 gctccataat tcattgccgt ttgcgtctgc cgcataaacc ttcatatcat ctgacccgaa 3440041 ataaaccgtt cccttcgcgt caatcagcgg cgccgttctg acagggccgt ctgtgtagaa 3440101 tgaccagttc atatccccgt ttttgctgat ggaaaacagc tcgccgcttc ctgagccgat 3440161 gtagatattg ccattatgat caatcgcagg agatgagctg gagaacccgt ttagcgggaa 3440221 tgtccatttc aaactgcctg ttgatgtata agcatacagc tgtccatctt ggttgccggc 3440281 ataaatgttt ccgtccttat caatcaccgg atatccttta aacgcatttg acgtcgttct 3440341 ggaccatttc acctgtccgg ttccggagtt gatcgcataa aacacgtaat tatatgtgcc 3440401 gacatacacg gtgccgtttt tggcaagcac cggcacagag ctgacgaccc catttgtttt 3440461 caacttccag cgctctgtcc aggttgattt tgacgtcggt ttgatcgcgt gaacataatt 3440521 atcaagtgtt gagaaataca acgtcccgtc tgaaccgatc accgtttcag agcttggccc 3440581 gccgcttaac ggaaccgttg ttaaaatttc tcccgtttct ttgtcaataa aataaatctt 3440641 tttgtcatag gatgccaaat agataacgcc gttggtccca agtacaggag attgcgtata 3440701 tgtttttcca agattgcccg tcacccattt gactgagccg tctggattaa aggctttcat 3440761 ttccccgtct ctggaatgaa gatatactgt gccgtctccg tcaatcacag cccccgctcc 3440821 attttgcgga gtcgttctga tgtcgttttg ccatttcagc gtcccgtctg tatttccggc 3440881 gaaccggctt tcgcgtgacc agttaaacat ggcaggcgcc atcgcttgta catcatatct 3440941 tcctggcaaa aagccagatg ctccattatt ttgagaaaac accgtttccg ccgcataagc 3441001 agctgtcggc tgaagcactt tggcagcggg cacatcagaa acagcgccgg ccgaaacagc 3441061 cgccgccacc gcagctcccg caatcaaagc tttcatacga aatgacttga ccatcattga 3441121 gacccccatt atatgtaact tctaatttgt gaccatcata acatattcat ccattttata 3441181 aatctatttc acaaaaacat cacaaactag aaaactatgt aagagtattc acggacgttt 3441241 tttcagcacc cgatcgaaat gcagccacaa accaaatgac gttgacagca gccgcagcga 3441301 gactaactcc caaaacaaag atcacctcag aaagcagatg gtcactaaag aaactaaaca 3441361 tcaagataaa accggccgaa gacaaatgaa tcaaaagccc gaagccgcaa agcaccgcca 3441421 tgacatacct cattgcatcg actccgagca tataaacgag aaatggaatg aaatacaaga 3441481 caaggatcat accgacagct gaccacatgc cagctgaatt aaactgattg gccgccgctc 3441541 ccgttccggc cagcggcgaa agtgaagccg ccacaatcac ggcgcaaaaa agaaacgcag 3441601 aaatggttgt catgatcgcc acgctatttt tttttgacat caaactcctc ctttaataga 3441661 aatattaacc ttttttatta taagtaagtt gaatgttata ttcattatat ttttaaaaaa 3441721 ttccagaata catacacaaa tgctatgctt ctttctagta tatttatata gtaaaaaaca 3441781 aaggataaaa gactcatttt tctgtaatat caggatttta tcaccatacc atattgcatg 3441841 tacatgtttt tcaaagtata ctattccaga ttaattcaga ggagagagaa aaatacatgg 3441901 aaaaaccagc aggattttgg attcgttttt tagcttattt tattgacggc attattgtat 3441961 ctgttcctag ttatattatt ctatttatta tcaattctgt gtttgtagct ggggctgtgg 3442021 caacaaaccc ttacatgacg gaagaagagt atttagtgaa atacatgacg cttgcatttt 3442081 tgcctactat gctgatcatg atcgtcatca gcgtgttata ttacgggctg ctcacagctt 3442141 ctaaaatgca aggcacactt ggcaaaaaaa ttcttggcct gaaagtggtc aatgaacaag 3442201 gtgaacgggt ttctgtcgga cagggaattg gccgttactt tgcctatatc ttatctggaa 3442261 tcatctttta tatcgggttt atcatgatcg cctttggaga gaaaaaaggc ctgcatgaca 3442321 tcatttgcaa aacacgtgtc gtgtataaat aatagaaaaa agtctagacg ccaataggca 3442381 tctagacttt tgttttcttt gcaataggct gccacgacag atacgtagcg cttctccaca 3442441 accactcaaa cggccccatc cgaaagacac gaagccaaag gtggctgaag accatttgaa 3442501 cggcacaaac agcaattgta atgagcacac cggcagcagg gtacactttt ccatacaggc 3442561 ccaagccgta atgataaaaa atccaagtac acacaataga ctgcatcaaa taattggtaa 3442621 atgccatcct cccaacagcg gagaatgatt gcagcactgt tctcactctt gttttatgat 3442681 aaagatagac aaccgttgta acatagaaaa acatgaggaa aggcgcgcca atcagcaaac 3442741 atatttcttt atccgttaca ctgtacagca cctgggcgcc gatgccgatg acaagcccag 3442801 ccatccataa tcgttttaat cctttgcgat gcttttccgg ttcatgcaaa taccgtgatt 3442861 ttgctgccgc agctcccagc aaaaacatgc tgaaatatgg aatggatgca aagaagtagt 3442921 tgagcggatt atacgtaagc atgccattcg aagacatgta aacaagacgg tcgtggatcc 3442981 gctgttctgc aatatccttc aggctgccgc ttccataaac atgaatcgct tgttttgcct 3443041 gctgtgttac cgcttgtacc cattcctgtc cgtttgattg atcaaaactt gtcaacatga 3443101 acggaatgga aaacagaaga tacaaagaga ccgcccatat cagcagtgtt ttcggctttg 3443161 cttttcgaaa caagagcagg acaaatccga gcagggcata ttctgttaaa atatccccgt 3443221 cccatatcaa aaaggcatga atcgttccaa acaagagaag cgccattaac cttctcacat 3443281 ataacggaac aaaccgtttc cctttgtttt ctgctctctc catcatgaca accatgccaa 3443341 atccaaataa aaaggaaaac aataaaatac attttgtttg aatgaagaat ttcagtatgt 3443401 ctgcggcggc aaaatcagct tcagaccact tatccatgaa aaaattctct tttccaagca 3443461 tagacaaata catatccgga taactgaaat gtgccagatt gacaaataag atgccgaaaa 3443521 tcgccattcc tctcagcaca tcaagcacac cgatccgctc atttgttaaa gtcggctgta 3443581 atgaagacat agccatcacg ctcctttttt ctgtacctta agggtaggaa aaaatgaagc 3443641 gcggtaacat cgatttaggt gtcaggccgg catgaaaacc ttacaatctt gtcatcttta 3443701 tggtttcatc acctttaaat ctaatgcttc gatattctgc aaaatgcgat caaagcgcaa 3443761 agcctgaggc tcacatggga agatgtggcc ttcatacggg tcgcctaacg tccggaaaaa 3443821 cggttcaaat aaaccaggaa ccaatacgcc caccatcttt gtatagtgag aatcaaggcg 3443881 ataggagtga acggtatttg cagggacatg caggaaatct cccggattca gctgaatttc 3443941 ctggccatct gtccacatcg tcatctggcc ttcaaggcaa taaaatgttt ctgtatgata 3444001 ttcatggtag tgatcaacga ttcggtcacc tttagggcct tcagatgata cgacgataaa 3444061 ctggccatct gtattttttt gtgcagccac aatgcggtga agctgatctc cagtcaacag 3444121 acgatctcct tctccagatt caagaacgta tggaaccgct ccatctggca gctctgtaag 3444181 ttccgctaat ttggccgaac atgcaggctt tgcttcatct agaaatacaa tgtccgctac 3444241 agcggctgct tctgcaaatc gctcgtttga gacttcttcg cttgcgtacg gcggatgttc 3444301 agcgtgatca tacggattcc caataacgga atacaagtgc gctacgtttc ctttcatcgt 3444361 gtaagacacc agtcttgttc tgtggctctg catccggtag ctgtgcggtg ttcccgccgg 3444421 aatgttggca taatcacctg atattaataa atagcgttca ccatcaagtg tcagttccag 3444481 tttcccgtcc aaaacgagaa ttccttcatg tgtgtccttg tggacgtgaa gcggaaaggc 3444541 atctcctttt cccccggaaa gaagcacgat ctcaaacaaa tcacctgtgc tcctcccatt 3444601 cgccatcacc gtggcaacct gtctgccgaa cagatagcgc tcgccttctc cgctccggag 3444661 caaataaggc attttttctt taggcaatga atgtgtacat aatgttttca tattatcgct 3444721 tcctccaatt tagaccagtc tatatattat cattcatttg tctagaccgt tctatataat 3444781 tgtaggagaa aggataacaa aatgctaccc tttttttctc accagcactg gtatttgttc 3444841 ggcaatgaga agaagaggcg ttttgtcttt attcgttaac gaaagcatga tgccgccctc 3444901 aatcatcgaa ttaatcagcg ttccaagctg atttgcttct tcttctgcaa atccgttttc 3444961 cattaatttt ctggcaaaaa ccgcttccca gcttttaaac accttcatgc aaaccgtccg 3445021 cagcggttca ctgattaacg ctgtctcact cgccagcaaa ccgactggaa tacctttaat 3445081 gctttctgtg ttgtcaaatt ggctggctgt ttttttgata aaaagctgaa tcgcttcaac 3445141 aggatcagag gattcatcca tgctttgctg tatcagatgt tcaacgatct tacctgtata 3445201 tgtaaccgct tcaattgcta gttcttcttt gccattcgga aaaaagtgat aaagcgatcc 3445261 ttttggagca ccgctttctt ttacaatctg gttcaaacct gtcgcgtgat atccttgcag 3445321 ctggaacaga cgtgacgccg tgtgaaggat tttttcacgt gaatctcctc tgctagtcat 3445381 taaaacattc cctcctaggt atggtagagc gacttatata atataaaaaa gaaccctgtg 3445441 attgtcaaaa ggggtaagac ccttccggat ggggtaatgt acaaaaacag cgtctaggag 3445501 ggatctctca atgacaatcg atcattcagt cacaaataca gagcagcttg aacaacagaa 3445561 ccccgccata aaaacaaagc tcaaactgaa aaagcttaag gatcaggtga tcgtcattac 3445621 cggcgcttca agcggtatcg gacttgtcac ggcgagaatg gcagctgaaa aaggcgcaaa 3445681 ggtcgtggca gcagcgcgaa atgaagaggc gctgaaggag ctcactgatg aacttaagga 3445741 aaaagggcac gacgccatat gggtaaaggc ggatgtcgga aaagaagagg acgtcaaccg 3445801 catcgcagaa accgcgatca gcacattcgg ccgctttgat acatgggtca acaatgcggc 3445861 cgtctcgact ttcggacacg ccatggacgt caccgtcgaa gacatgaagc gcatgttcga 3445921 cacaaatttc tggggacctg tttacggaac aagagcggct gtcaaacact acaccggcag 3445981 aggtgtgccg ggcgcactca ttaatgtagg aagcctgttc ggagacaggg gaacggtcat 3446041 tcaatccaca tatgcatctg ccaaatttgc gcttcacggc tggacggaaa gcatccgaat 3446101 ggagcttgaa aaggaacagg cgcccgtctc ggtaacgctc atccacccgg gcagaattga 3446161 cacaccatat aacgagcatg cgcacagcta cctcgacaaa cagccggctc attaccgctc 3446221 catgatctat ccgccggaag cggtcgccga agcgatcctg tttgccgccg aacaccctaa 3446281 gcgcgacatg tacatcggct cacaggccaa agccatcgcc atgctgggcg cgctttttcc 3446341 tcgtctgacc gacagactga tggaaaaaat catgtatcac agccagcatg ccgaaagacc 3446401 gtccaatccg agagaagaaa gcgctcttta tgatgctggc tgcggtatgc atgacagagg 3446461 cacaaataaa ggatggatga ggtcaagaag ctactacaca aaagcgacga agcgcccaat 3446521 tgtatcggcg gctgttgttg ccggactagt ggcttgggct gccgccaaac gatgcagata 3446581 atctctgacc ataagaaaaa cccatgctgt tccagcgaac catgggtttt tcagctgtta 3446641 atcgataaaa gccttgttca tacgctgcag cagctcgccg aacatctctt tttcctgtgt 3446701 tgaccattct ttcagcatct gttcataacg ttcaaggcgc ttttgctgat cggcttttaa 3446761 tagttgtttg ccgagttttg taatggtaaa caggctgact ctcccatcag acgggtctga 3446821 gaaacgatag atgagctcct ttgcctctaa tgcagctgct tgtcttgaaa gagtagaaat 3446881 atcaagctta aacgattcag ccaattcctt aacacgagca ggcccaaact catccaattg 3446941 tctcagtaat aagtacgaag atctctccaa attccctgtt cttttctccg attgatccag 3447001 ataaacagct ctcctgataa aagtcgtcag ctcatattca attaattcaa ctggattttg 3447061 attttgcaat cgctctcgct ccctattcca atctccggca ttgacaacat catatatact 3447121 tgtataatac aaatgtacat taactgaata aatacaagtc gttatatgac taaatcaatt 3447181 attatacttg tatagtacaa tcatataaaa agaaagtaaa gcgattcctc agaaccatcc 3447241 tagaagcaag caccagaaag gaggaagctg ttctgattgg agagcagcac ttgatgtgaa 3447301 agtcatacga attattttgc aagtgttgat attatatgta ttttttatga tcggggaagc 3447361 cattcagcat ctgtttcatt tacccgtgtc aggaagcatc gttggattgg tattgcttct 3447421 gatctgcttg ggcctccgta ttgttcccgt ctccatcatt gaagacggag cagggttttt 3447481 attatccttc cttccattgt tgttcatccc ggcaatgaca ggagtgataa actatccgtc 3447541 tctcatttca ttcaatggcc tgatgctgct gattacagtc gttctcagca ccatcgtcac 3447601 gatcattgcg gctggattcg ccagccagct attagagaaa aaagcaaaaa aacgggagga 3447661 gaaagagaaa tgcagcaagc atgtatcgcg atcattataa ttcttttaac agttgccgct 3447721 tatttagcga tggtcaaact ctataagcga ttcccgcttc catttctgat ccctgttctg 3447781 acaacgacaa ttttgattgt agcggctttg atgatgtttc atgtttccta tgaaggctat 3447841 atgatcgggg ggaaatggat caattctttg cttgggccgg ctgttgtggc gctggcctat 3447901 ccgctttata agcaatggca tatcattgtc aaacattgtg ttcccatttt aggcggcgtc 3447961 ctggtcggct tatgcatggg aatgatcagc gggctgatct tcgcagaagc attcgggatt 3448021 gatcatgatc tcttattatc cattctgcca aaatcgatca caacccctgt cgctattcag 3448081 atcgccgccg gtcttggcgg cgtcccttcc atgacagtcg tatttgtcat gattgcgggc 3448141 ttttcaggcg tcatcctcgg gccgcttttc ctaaaatggc ttcgcatacg cagctcccta 3448201 ggacaaggca ttgcattagg cagcgcctcc catgcactgg gtacctccaa agcgttggaa 3448261 tatggggaat tggccgtatc catgagttcc gtctccatga cgctttgtgc ggtgctcggc 3448321 tcattcttcg gcccgctcgt cgtctggctg tttcatattt aacaaagaaa gactgccccg 3448381 ggggagggca gtctttttcg tttaagaagc aaaaaaatca atcaacggct gaaagtcctt 3448441 agataaatca acgtcattcg gttctgcttg aagcaggcgg tcaatcatac gctccagctc 3448501 ctcaacatca ttcttatccg tatattcaat gaagtttaag ctttcaagcc aatcccgata 3448561 tgaatgtttg gctttgccat agctgtttcc aaagacaagg caaggtgttt tggtgataat 3448621 cgagaaaatc atcgcgtgaa ggcggtcggt aatcaccaat ttactggagc cgatgcggtc 3448681 cagcatctcc ataaaatgct tttcacgatc agcgtaatcg atggtgtcta ccgtatccag 3448741 caccgtatcg gtacgctctg tgtaagttgt tttttctgcc cattgcttca tctgtgaaat 3448801 aaaatcttcg tcagtcactt tctccttatc cgctcttaaa ataaagagaa cgccgtcccg 3448861 ctcgagctct cgcggcacaa tatccaagga aagcaccatg tccggtgtaa agatcacatt 3448921 ggagttgaag gtctctttca caacatccag tgtttgcgtc tcacgcgcag caatcgttaa 3448981 gtttgtattt tgatggtacg catcctgtgt ttttttcttt tccttctgtc cttcctctgt 3449041 atcctcaaaa taaacggatt gtggcagaga aattgatttg tagtctttaa acgccgaaaa 3449101 gacctttctt ctgtcttcct caatatcgag ataaaggttt cctaaattcc ctccgcctgt 3449161 aaagcagaca atatcgtctt cacgaatgat ctccttcacc agttcaatgc cctcatccgt 3449221 cgcataatcc ataatctcaa tgtattcata atacggaaaa tgatttttga taaatttctc 3449281 ttccgcatac gcaatcgctt ggtcgccaat gtttgtgtag ctaggggaac caaacaaaaa 3449341 tacttttcgt ttatcattta acagagcttc cggctccaca tttggcgcaa tgccttttac 3449401 tagttttttg cctttgattt cttgtacagt catatctgcg tcctccttct gggatgaatt 3449461 cctcattgtg tgttaactgt ctctacccaa aaagaaggat ggctatgcat tggcatgtgc 3449521 atcggctata tcagaaacat cgttttcgcc aatttgatag acgctgcaat gtcccgcgcc 3449581 gttctttcca tatattccgc ggcatgttca aacgcgtctt ctagtggcac ggctccgggg 3449641 acgatgctga aaagcgcatc gattccgtgt tgatagacgg cattactgtc tcgggaaatt 3449701 gatcccgcaa tgccgataac gggcacatcg tatgatttag cggccttggc caccccgatc 3449761 ggtgtttttc catgaaccgt ttggctgtcg attcgtccct cgccggtaat cacaaggtct 3449821 gcatcctgaa cgatactttc aaaatcaacc gcttcaagga caatatcaat gcctcttttc 3449881 aggtcagcct gaagataagt tagcaggctc catccaagac cgcccgctgc accggcgccc 3449941 tctgtatctc ggaaggttga tccgagcgct ttttctgcca tatcagcgaa atggcttacg 3450001 ttctggtcta gtacatccaa catgtcggcc gtcgcgcctt tttgcggccc gaaaacagcc 3450061 gtagcaccct ttggtcctgt taacggattg tccacgtcac aggcaacttc cagtttgaca 3450121 ttccgcaatc tggaatcaag cccgctcaca tctattgatg caagctgaga taacgcgccg 3450181 ccccctgggc caatctcgct gcctgagtta tcaagaagcc ttccgcccaa tgcctgaatc 3450241 atcccggctc ccccgtcgtt cgtggcgctt ccgccgattc cgatgatcaa tcgctccgct 3450301 cccgcatcaa gagctgctcc gattaattct cccgttcccc ttgttgtagt gatgagcgga 3450361 tttcgcttat ctacaggcac cagatgcagc cctgaagcag cagccatttc aatcacagct 3450421 gttctcccat ctcccatcat gccaaagaaa gctctcaccg gttcccccag cggccctgtg 3450481 acaacttgct ctatgatcct tccattggtc gcatcgacca gagattgaac ggttccctcg 3450541 ccgccatccg ccaccggcaa ttttctgtaa tcagcacccg gaaagaccga tttgaaacct 3450601 ctttctatcg cttcggctgc ctccagagct gataagcttt ccttaaaaga atcaggtgca 3450661 atgatgattt tcatccaaat cgcctctttc aaaacatgat tcacttaacc tattgatctc 3450721 caatgtacca taattgatct ggaaatacat accatgcaat atggtaaaaa tttaaataaa 3450781 aattagaaat gaaagtgttt gcataaaaga aatattcacg ttatcatact tgtatacaag 3450841 tatactcctt gagtgaggaa ggtgagtgta tgctagactc caaagacctg ttgtatcccg 3450901 caaaatggct ctcaaaagcg tcaaccggag ttcgtgtcgc atacgagctg agaatgcgga 3450961 tcgtttcagg tctgattgaa agcggtacca ttttatcaga aaatacaatc gccgccgagt 3451021 tttcagtaag ccgttcgccg gttcgcgaag cgctaaaaat actcgcatcc gaaaaaatca 3451081 tccgcttaga acgaatggga gcggtcgtaa ttggtttaac tgagaagaaa atcgcggaaa 3451141 tttatgatgt gcggttacta ttagaaacat ttgtctttga acggcttgtc aaaatagaca 3451201 ttgagccttt agttaaggat ctcagcaaaa ttcttgaaat gatgaaagtc tcaatcaaat 3451261 atgaggatgc tgacgaattt tcatttcaag atgtgctgtt ccatgaaacg attatccgag 3451321 cgattgatca ttcatacatt cagatgatct ggaacaatct aaaacccgtc atggaaagct 3451381 ttattctttt atcgatgcgg gtacggttaa aggaaaagta tgaagacttc acaaggattt 3451441 tagataacca cgagctttat attcaagcca tcaaaacaaa ggatagggcg ctgatgattc 3451501 agtctcttca ccaaaacttt gatgatgtgc aggataaggt agaagaccta tggctctcac 3451561 aacaaatgct ggcaaaagga gctgaataca acaatgacta gttatatgtt aggaatcgat 3451621 atcggcacga caagcacaaa agctgtgctg ttcagtgaaa acggagatgt ggtacagaaa 3451681 gaaagcatcg gctacccgct ctatacaccg gacatctcaa cagctgaaca aaatccggaa 3451741 gagatttttc aggcagtcat ccatacaaca gcgagaatta caaaacagca tcccgaaaaa 3451801 cggatctctt tcatttcgtt cagcagcgcc atgcacagcg tcattgcaat cgacgaaaat 3451861 gacaagccgc tgacgccatg cattacatgg gccgacaaca gaagtgaagg ctgggcgcat 3451921 aagatcaaag aggaattgaa cggacatgag gtgtacaaac ggacgggaac accgattcat 3451981 ccgatggcac cgttaagtaa aattgcctgg atcacgaatg aaagaaaaga aatcgcttcc 3452041 aaggcaaaaa aatatatcgg catcaaagaa tacattttta aacagctgtt caatgagtat 3452101 gtcatcgatt actcattggc atcagcgaca ggcatgatga acctgaaggg cttggattgg 3452161 gacgaagagg cactgcgcat cgcaggcatc acgccggatc acttatccaa actcgtgccg 3452221 acaaccgaga tctttcagca ctgcagcccg gaaatagcga tccaaatggg aatcgatccg 3452281 gaaacgcctt ttgtcatcgg cgccagcgac ggcgtgctgt ccaacctcgg cgtcaacgcc 3452341 attaaaaagg gtgaaatcgc cgtcaccatc ggtacaagcg gtgccattcg gacgattatt 3452401 gacaagccgc aaaccgatga aaaagggaga attttttgct atgccttgac ggacaagcat 3452461 tgggttattg ggggacctgt gaacaatggg ggcatcgtcc ttcgctggat cagagacgag 3452521 tttgcctcct ccgaaatcga aacagcgaca cggctgggca ttgatccata tgacgtgctg 3452581 acgaaaattg cccaacgcgt cagacccggt tctgacggtc tgctgttcca cccatatctc 3452641 gccggagaac gcgctccgtt gtggaatccg gatgtacgcg gctcattttt cggcttgacc 3452701 atgtcgcata agaaagagca tatgatacgc gcggcattgg aaggcgtcat ttacaacctg 3452761 tacacggtgt tcttggcgtt aactgaatgc atggatggcc cggtaacccg catccaagcg 3452821 acagggggtt ttgcaaggtc ggaggtttgg cgccaaatga tgtcggatat cttcgaatca 3452881 gaggttgtcg ttccggaaag ctacgaaagc tcatgtctcg gcgcctgcat tttaggcctg 3452941 tatgcaacag gaaaaatcga ttctttcgac gccgtgtccg atatgatcgg cagcacatac 3453001 agacatacgc cgatcgaaga ctcagccaag gaatacagaa cattaatgcc gattttcatc 3453061 aatctatcaa gattattaga aaatcaatat acacaaattg cagattatca gaggggctta 3453121 atcacacaca aatagtacat gacatgaagg ggagggcatt accatgccgt taatcatcgt 3453181 tgcacttggg atcttagcat tactatttct gattatgggc ttaaaattaa acacatttat 3453241 ttccctgctg gtcgtatcgt tcggcgtggc actggcactc gggatgccgt tcgataaagt 3453301 tgtcagctcc atcgaagcag gaataggggg gactcttggc cacatcgcgc tcatcttcgg 3453361 actcggtgcg atgctgggca aactgatcgc ggattcagga ggcgcacagc gcattgcgat 3453421 gacgctcgtc aacaaattcg gtgagaaaaa tattcaatgg gccgttgtca ttgcctcatt 3453481 cattattggg attgcgttat tttttgaagt aggactggtt ctattaattc cgattgtctt 3453541 tgcgatttca agagaattga agatttctat tttatttctc ggaatcccga tggtcgcggc 3453601 actatccgtc acacacggtt tcctgccgcc gcacccggga cctacggcga tcgccggtga 3453661 gtatggcgca aacattggag aagtgctgct gtacggcttt atcgttgctg ttccgacagt 3453721 gctcattgca gggccgttat ttacaaagtt cgcgaaaaaa atcgttcctg catcatttgc 3453781 gaaaaacggc aatattgcat cactcggcac acaaaaaaca tttaaccttg aagaaacacc 3453841 cggctttgga atcagtgtct ttactgcaat gctcccgatt atcatcatgt cggtcgcgac 3453901 cattatcgac ctgcttcaag aaacaatcgg gtttgcagat aacggagttt tagcttttat 3453961 cagattgatt ggaaacgcat cgactgctat gattatttcg ttattggtcg cagtctatac 3454021 aatgggcatc aagcgcaaca ttccagtcaa aaccgtgatg gattcttgtt caactgccat 3454081 ttcacaaatc ggcatgatgc ttttgatcat cggaggaggc ggcgccttca aacaagtgct 3454141 gatcaacggc ggtgtcggcg attacgtagc agacttattc aaaggaacgg cattatcgcc 3454201 aatcattctg gcatggctca tcgcagcgat cctgcgcatt tctctaggat cggcgactgt 3454261 tgccgcacta agcacaacag gtctggtcat tccgttattg ggccattctg atgttaacct 3454321 ggcgttagtc gtactcgcaa caggagccgg aagtgtcatc gcttcacacg tcaatgacgc 3454381 cggcttctgg atgttcaagg aatacttcgg attaagcatg aaagaaacat tcgccacatg 3454441 gacattgctg gaaaccatta tttccgttgc tggactggga ttcattttat tgttaagttt 3454501 agttgtatga aattaagaag gagctgtaac acatgttcaa ttcgattggt gtcataggct 3454561 taggcgtaat gggaagcaac atcgccttaa acatggcaaa taaaggcgaa aacgtcgctg 3454621 tctataatta caccagagat ttaacggacc agcttatcca aaagctggat ggacaatctc 3454681 tcagcccgta ttacgagctt gaggactttg ttcaatcgtt agaaaaacca agaaaaatct 3454741 ttttgatggt cacagcggga aaacccgtag attccgtcat ccaatcatta aagcctttgc 3454801 ttgaagaagg cgacgtcatc atggacggag gaaactccca ctatgaagac acagaaagaa 3454861 gatatgacga gctgaaggaa aaagggatcg gctacctggg agtcggcatt tccggcggtg 3454921 aagtcggtgc gttaacaggg ccttccatca tgccgggcgg agatcgcgac gtctatgaga 3454981 aagccgctcc tatcctgacg aaaatcgcag cccaagtcgg agatgaccct tgctgtgtct 3455041 atatcggacc aaaaggggca gggcacttta caaaaatggt gcacaacggc attgaatatg 3455101 ccgacatgca gctgattgca gaagcttata cgtttctaag agaaacgctt cgtctgccgc 3455161 tagatgaaat tgcatctatt tttgaaacat ggaatcaagg tgagctgaaa agctatttaa 3455221 tagagattac agctgagatt ttacgcaaaa aagacgaaaa aacaggacag cctctgatcg 3455281 atgtcatcct tgataaaacc ggccaaaaag gcaccggaaa atggacgagc atgcaggcga 3455341 ttgataacgg catcccgtcc acgatcatca cagagtcctt gttcgcccgc tacttgtcat 3455401 ctttaaaaga agaacggatg gcagctcaag atgtattagc aggcccggaa gccgaagaaa 3455461 aacacttgga taaagacact tggattgaat acgtcagaca ggctctttac atggggaaag 3455521 tatgcgccta tgcacaaggc tttgcccaat ataagatgtc atctgagctt tacggctgga 3455581 atctgccgct caaagacatc gccttgattt tccgaggcgg ctgcatcatc cgcgctgatt 3455641 tcctaaacgt gatcagcgaa gcattcagtg agcagccaaa tctggctaac ctgctgatcg 3455701 cgccttattt cacagataag ctccatgcct atcaaacagg cctgcgaaaa gtcgtttgcg 3455761 agggtatcag caccggaatc tctttcccat gcttaactac cgcgctctct tattacgacg 3455821 gctaccgcac agggcgttcc aatgcgaacc tcttgcaggc acagcgcgat tactttggcg 3455881 ctcacacgta cgaacggact gatatggacg gcgtcttcca tacgaattgg tctgaataac 3455941 ctgtattaaa aacacggtca gtttcaactg aaccgtgttt ttttcttcta tcccaaacaa 3456001 cagaagacat aagttatgtt ttaaatatca taaacagtga tacaataata gctagaaaca 3456061 atccccaaga tcatcatgtg acagcagatt gctgttccgt tctattctgc ttttggccat 3456121 tgtcctttgc ccttgaccat ggtgtcataa aatgttcaaa tgccaaaacg gcctggcatt 3456181 ctgatttaca aaagtccctg aaaaccttat ctaattgaga atcagcctct catttattat 3456241 aaaagaaatg cctaaatcct acctgtcaca cctttattaa gatgaaaaaa agtaggttat 3456301 ggcttgacaa aaaatatata ttaattaata attcatatat aattagaatt attattgaaa 3456361 gcgattatgc tttctaatac atttttagga ggaatataca ttatgtcttt aatcggtaaa 3456421 gaagtacttc cattcgaagc aaaagcattc aaaaacggtg aattcatcga tgtaacaaac 3456481 gaagatttga aaggccaatg gagcgtattc tgcttctacc cagcagattt ctctttcgta 3456541 tgcccaactg agcttgaaga tcttcaagaa caatatgctg cacttaaaga attaggtgtt 3456601 gaagtatact ctgtttctac agatactcac ttcgtacaca aaggctggca tgacagctct 3456661 gaaaaaatca gcaaaatcac ttacgcaatg atcggtgacc catctcaaac gatctctcgc 3456721 aacttcgatg ttcttgacga agaaactggc cttgctgacc gcggaacatt catcatcgat 3456781 ccagacggcg ttatccaaac tgttgaaatc aatgcaggcg gtatcggccg tgacgcaagc 3456841 aaccttgtaa acaaagtaaa agcagctcaa tacgttcgtc aaaacccagg tgaagtttgc 3456901 ccggctaaat gggaagaagg cggcgaaact cttacaccta gccttgatct agtaggtaaa 3456961 atctaaggag tgcattcaat tggtacttga tgcaaatatc aaagcacaat taaatcaata 3457021 tatgcagcta attgagaatg acattgttct caaagttagc gcaggcgaag atgacacttc 3457081 taaggacatg ctggctctcg ttgatgagct ggcttccatg tcatcgaaaa tttcagttga 3457141 aaaagctgaa ttaaacagaa cgccgagctt cagtgtcaat cgtgtcggag aagacactgg 3457201 cgtgactttc gccggtatcc ctctgggcca cgaattcaca tcattagtgt tggcgttgct 3457261 ccaagtgagc ggcagaccgc ctaaggtaga ccaaaaagtc attgatcagg tgaagaagat 3457321 cagtggtgaa taccacttcg aatcttatat cagcctgaca tgccacaact gtcctgatgt 3457381 tgtacaagct ttaaacatga tgagcgtgct gaacccgaac attacgcaca cgatgattga 3457441 cggtgcagca tacaaagcag aagttgaaag caaaaacatc atggcagtgc cgaccgttta 3457501 cctgaatggc gaatccttcg gaagcggccg tatgacgctt gaagaaattc ttgcgaaaat 3457561 gggcagcggc acagatgcat ctgagtttgc tgacaaagag ccgtttgacg ttcttgtggt 3457621 cggaggcgga cctgctggtg caagtgcagc gatctacact gcacgtaaag gcatccgaac 3457681 tggtgttgtc gctgagcgct tcggcggaca ggttctcgac accatgagca tcgaaaactt 3457741 catcagcgtc aaagcgacgg aaggaccgaa gctagcggca agtcttgaag agcatgtgaa 3457801 ggaatatgat attgatgtca tgaaccttca gcgtgcgaaa cgccttgaga agaaagatct 3457861 gttcgaactt gaactcgaaa acggcgctgt cctgaaaagt aaaacagtga tcctttcaac 3457921 aggtgcacgc tggcgcaatg tcaacgtccc cggtgaacaa gagttcaaaa acaaaggtgt 3457981 cgcatactgc ccgcactgtg atgggccatt gtttgaaggc aaagacgttg cggtaatcgg 3458041 cggcggaaac tctggtatcg aagcagcgat tgatcttgca ggtattgtca atcacgttac 3458101 tgtactagaa ttcgcgccgg aactgaaagc agacgaagtc ctgcaaaaac gtctctacag 3458161 cctgcctaac gttactgtcg tgaaaaacgc acaaacaaaa gaaatcacag gtgatcagag 3458221 tgttaacggc atcacatatg tagaccgcga aacaggcgaa gaaaaacacg ttgaacttca 3458281 aggtgtattc gtccaaatcg gtctcgtgcc aaacacagaa tggttagaag gaacggttga 3458341 acgcaaccgc atgggcgaaa ttattgtcga caaacacggc gcaacaagcg taccaggctt 3458401 atttgctgcc ggcgactgca cagacagtgc gtacaaccaa attattattt ctatgggatc 3458461 aggtgcaact gccgccctcg gcgcgtttga ttacctaatc cgtaactaat ataagaaatc 3458521 cgctatattg ccagattggc aggatagcgg atttttcttt ttctacagaa aaaaaccgaa 3458581 ccaggcacta cggtaaaagt gctcgattcg agcgcttctt atagttcctc accattcgtt 3458641 tgaatgacat ttttatacca ctcaaaggag tctttcttat atcgtttcat ggatccgttt 3458701 ccttcattgt cacgatcaac atagatcatg ccgtagcgtt ttttcatttc gccagttgtg 3458761 aaggagacaa tatcaataat gccccacggc gtgtagccaa ttaaatcaac accatcgtac 3458821 gtgaccgctt ttttcaatgc ttcaatatgc gattttaaat attgaatgcg ttccggatca 3458881 tgaaccttgc cgtcctcctc cagcgtatcc actgcgccaa agccattttc aacgatgaat 3458941 aacgggattt ggtatcggtc ataaaaacga tttaacgtat atctcaaccc ggttggatca 3459001 atcgcccatc cccagtcact cgaagtgatg tacggatttt cgacaccatt cggcaagccg 3459061 ccatttacaa tatcgccagt gttatcattt ttcacatcgc ttttcacagt tgttgacatg 3459121 taatagctga agcctaagta atcgacggtt ccgtttctta aaatctcatc atcgccgtct 3459181 tcgaatgtga tgttgtagcc ttcgcgttca aattccttca acgcgtagct tggataataa 3459241 ccgcgaacct gcacatcagg gaagaaatag cgctgcctca tttcttcttc agccagcatc 3459301 acatcttcag gattggagga gaaaggataa atcggcacgt gtgataccat ggccccaatc 3459361 tggaactctg gattgatgtc ttttcctttt gccactgcta aggcgctcgc cactaattca 3459421 tggtgcgccg tttgatacat gacttccttg gcgttttcgt tttcgccaac cacaacacct 3459481 gaattcgtcc ataggaacag cggattgttc acatccattt ggttgttaat ctcgttaaat 3459541 gtcatccagt acttcacttt atctttgtaa cgggtaaagc aagcctctgc gaagttgacg 3459601 aagaagtcca cgactttccg gtttctgaag ccgccatatt ctcttgccag gtgcagcggc 3459661 atttcaaagt gagacagggt aatgaccggc tcgatcccat gcttcagcaa ttcatcaaac 3459721 acatcatcat aaaactgcaa accagcttcg ttcggttcag cctcatcgcc tttcggaaaa 3459781 atccggctcc agccgatgga cgtccgcaga cattttaatc ccatttccgc aaacaaagcg 3459841 atatcttcct tgtatctgtg atagaaatca atggcttcat ggtttggata aaattcgttt 3459901 tcttcaatcg tgtcagtgat ttttctcggc acgccgtgcg cacccgctgt catcacatcg 3459961 acgacactcg gccctttacc gccttgattc catccgcctt caaattggtg ggcagctaaa 3460021 gcaccgcccc ataaaaaatc ctttggcatg tttcccatgt ttaattcctc ctcagcttac 3460081 gactgtaaat attttttgat gtaatgcact ttcctcaatg tcttcaatga aagctttatc 3460141 aaactcaaca agcacttcgc cttttttgac ggtatcgcct tcttttacct tcaaggaaaa 3460201 aggcgtgccg tcaaatgtca ccgtatccag cccgatgtgc gcaagcaatt cgacgccgga 3460261 cgctgaacgc aggccaatcg catgctttgt aggcgtaacc atgacaaccg taatgacgcc 3460321 gggatggtag catcgatttc acgatatcct tcgctttagg ggtagaccgc ttcagcacca 3460381 atcgaagtct ggtagcgcag cgagaagccc caatcacatt ctcttccccg cctacggcct 3460441 ctaaaatgtc ttttgctagt ctcgtataat ctctcacttt ccccgacatt tcacccaccc 3460501 cttcgttttg gttacgcttt cattataatt gtaacggtat aatttatcaa ttccgaaaca 3460561 aaatatttac gcactaacta tcattgtaag cggtttatgc tataattttg acaagtgaaa 3460621 ctaaacgaat aaatgaggaa tgcgtatgtt aaaataccag caaatcgcaa cggaaattga 3460681 aacatatata gaagaacacc agcttcagca gggagacaaa ctgccagtcc tagaaaccct 3460741 catggcccag tttgaagtca gcaaaagcac catcacaaag tccctcgagc tattagagca 3460801 aaaaggcgcg atctttcagg tcagaggaag cggcattttc gtcagaaaac ataaacgaaa 3460861 aggctatatc agccttctgt cgaatcaggg atttaaaaaa gatctcgagg atttcaacgt 3460921 cacctcaaaa gtcatcgaac tggacgtgag aaagccaaca ccggaagcgg cggaaaacct 3460981 gaacatcgga atggacgagg acatctacta tgtcaaaagg gtccgctaca tcaacggcca 3461041 gaccctttgc tacgaagaat cctattacac caaatccatc gtgacgtatt taaacaacga 3461101 aatcgtctcc cactccatct tccattacat ccgggaagga ctggggttga agattggttt 3461161 ttctgatttg tttctgcacg tgggccagct taatgaggaa gaagcggaat atttgggatt 3461221 agaggctgga ctgccgaagc tgtatataga aagtattttt cacctgacaa atgggcagcc 3461281 gtttgattac tcgaagattt cgtataatta tgagcagtcg cagtttgtgg tacaggctaa 3461341 tagtttttta ttatagggct cttcactacg gtaggtggtc gacatgtaca aaattatcat 3461401 tcctgccata ctagccatct ttgcgctctg gatactctta cagatttcac tagagatgag 3461461 catcgttaag aatccaatga actactttat cgtattcatt atctttttcc tctttgtaaa 3461521 gatggtgaaa gaaaaacaat aatagtttgg gcgatgcaaa cagaaaaaca tccttccctt 3461581 aacaaactca gccagtcaca tgcattaatc ttgatgttaa tgatatatag gtgcacataa 3461641 aaagctactt cattgtgaag tagctccctt tattaaaggc ccattttgat ccatctagtt 3461701 ttagaaaagc gaaggacaat cgcatttatg ataataattg aaactaaata caaaataata 3461761 aataaaacat cattactccc aagtgtcatg ttatcagatt gcagcactct ttctattcgg 3461821 gggtacatag tgttacctgc ctcaaaagga gcaatgaaac caaacgtttt attgcttata 3461881 gctactaaga taacagaagt catccaataa acgatactga cacctatact aattaatata 3461941 ttaggacata acacgcttat agttccgata attagaatat actgcagtat aactgcagaa 3462001 aataaaaaaa gtaataatgc aaaatgcgaa aaatcatggt acatcaacga tatgattagc 3462061 aggcctagcg ttataaatgc aaaacattct aaaaataaaa cagctatctt tttataaaag 3462121 aaagtataga tgttctctcc aattaacttg taaaagagaa tatttttgtt tgaatactct 3462181 ctattaataa agaaagctat aacaaatgaa aataacatca aaccaaactg ggtcgcaaca 3462241 gtataggagc taaagaaaaa catttcaggt gtaacattac tgactttatc gattccaaca 3462301 agtaaaaaat aacccagcaa aaataaaaat acaaacattg ctcctaaaat aatgataact 3462361 ttgttgctaa tactcttttt aaactctaat ttcatctcaa gcccccactg ttttattact 3462421 catttatata cacttcaatt aatttatcca ctgaatgata ttgttgaatt tcttggtgat 3462481 taaatatata ataatcccct tctatcgcct ttaaatcaga caaatcatgt gtaatgttga 3462541 tgataatctt ctcggggttc tcctgaatat acttgtttaa gaagccatga atctctataa 3462601 ccgttttttt gtctaatgaa ttcgttattt catctaaaac aataatattt ttatcctcta 3462661 ataagaaact gagcaatttt aatttttgct tttgtccatc actcaaattt ttgatcagaa 3462721 cttttccatc aatattatcc agattaagta aatatgcgat tttatctatc atttttgcat 3462781 caaatttttt actcaaaaag tgtaataaaa agtccttaga aacatcatta ggtatattcg 3462841 acgagctgga tattaaagaa acattttgac gaatatctct gccgattctt ttgctattat 3462901 tcaacaaaaa gtctttagca agctgtgatt taccgactcc attttttccg acaacgtgat 3462961 taattttccc gctcgaaaaa tgcaagtcgg tgtcctgaag taacgttttg cctttcactt 3463021 ttaaagtgta attcgctata ttcatataca tactcctagg aaatatttgc ataataataa 3463081 aatgttctgc cttgtgattt gttactaatg tctaagcttt tgaggtacct ctttcgtttc 3463141 cgatccggaa gcgaaagaaa tgtttttaga tggctaattt ggagatcttt tactctagtt 3463201 tacaatatat aatatccaat gtacaactga attcactgca aggccaatcc ctataatttg 3463261 aatcgtaaga actaaccaat gatttgtctt aaaacggcta tattcatcta agctcagaaa 3463321 agctaaaaga attttgtaac catcagaatt caatattggg attaagttcc acaataaagt 3463381 agacgagaaa agcataaatg ccatagttaa tgcttcactg gaaaatgtaa attgatttat 3463441 taattctaat gtatttatta aaagataatt gataaacaag ccaaataaat gaacgattat 3463501 cttttcattt cttgatagca tgtaggtttc attcaattgg acataaaaag caggaaatac 3463561 ataaaaattc agtttgaatc ccactttatc aaagtttttc ccgaaaaatt ttaaggaata 3463621 aatatgtccc agttcatgaa gcactatatt cattataaaa taaataacta taattatcca 3463681 cattttccag ccgtaaaata ctgaggacaa tccattttgc aattttatta aatgaatata 3463741 atttaatatg aacatgagag ccgtaaagga taagaacaga taaaaaaact ttggtgatac 3463801 tttctcttta tacattttaa aacgtaataa ttgtttatct gacagagaat ttaaactatt 3463861 tttatagtat tctccgcttt ttttgtcttt tataaatacg ttgttttgca caagcacttc 3463921 atatttttca tcttcatact ttaaaatttt cattatagta tttttccata taaggataga 3463981 agtagtttat tttttctgca gagttgaata aggaaccaca aactccacaa atagaggaaa 3464041 attcataagg aatgtcaaat tcctctattt tgttattttc ttttaaaata ttcaaaaacc 3464101 atttgaatcc ttcttttcta agaataaata atagcaaatt ggaatttaac ttttccacgg 3464161 ttctttcgaa actttggtta tattcttccc ttagggttat tttcgtttca aaaatagcag 3464221 gggaacaaca tggataaatt tctccatcat gatgatatac aatgtcatat ccgggacaat 3464281 gtaaggaatc ttcatcttca agactgtaaa atttatgtat gttttcttgc ttaattctag 3464341 ttttagcagc gccaactgat atcattggaa attttgttat ctttacacct aagattgaat 3464401 cccccaattc ctctaaaatg tggttggaca ttttgtcttt ggtaactgcc atattaagag 3464461 aaatatcgat atcagggtat ttcctgctat gttctaatat gtttttaata ctggaagact 3464521 tgacaaatgg agcatggtac tcatcataac ttatagtcag tgctatcaca tttaaagaat 3464581 tcatatcatg aaagtactcc tggacctttt tcttgctcaa accccaaaat ccattagaga 3464641 tcaacgttat ttgtttttca tatggtttaa tgatttccat tagttctttt aaaaatttat 3464701 aatctaaaaa aacttcccca cctgtaaaag aaatcacttg aatggttttg ttttttgcaa 3464761 attcagttac taactctctt atgtattctt tttccatcct ggttgttgaa gttggtgaac 3464821 tagaaaaaca acaatggtca caggatgcat tacaccttga atctaaattg attgatactg 3464881 ttttattata catgaaatat cccccaacaa atggtaaagg agagttagac tctcctttgt 3464941 acccctctaa ttaatgacca cttccaagaa tccagcgatt ttcttttgat tttacaaaat 3465001 accaaagatc attcactttt gctaactttt gtgattcatc taatagaccc ttaaattcta 3465061 agtttttcac agtctcattg ttagtgattt cctttttcat attatccctc ctccttttct 3465121 aatataaacc aattattcta tatcattcaa tacatgtcaa tatattgtac ctaaaaaatc 3465181 tgaaaaatgt cactattctt ggtatataaa gcctatagtc ctctagcccc tctaagctat 3465241 accgaatgaa aggccatagt ttgatttaaa gcttcgtaat gaaaagtaaa acatcaatat 3465301 tgactacact agttaaggga tatacagatt ttaagtggaa gaaatgaggc aaacaatctt 3465361 accctaaacc aacctgtact gaaaagctgt tttaagctct tgcttacccc atttggcacc 3465421 tctttctctc gttttaattg tctctaaaag cagttatgcg gtactatcat ataaaggtcc 3465481 aatgtttaaa aataatgtca tacttttaaa ttcaccttat catgcacatg ctcataaaga 3465541 ggggtttatt ctaaaaaggg gatggacggt tttggaaagc aagtacctag atctactcgc 3465601 acaaaaatac gattgtgaag aaaaagtggt aacagaaatc atcaatttga aagcgatatt 3465661 gaacctgcca aaaggcaccg agcattttgt cagtgatctg cacggagagt atcaggcatt 3465721 ccagcacgtg ttgcgcaatg gttcaggacg agtcaaagag aagatacgcg acatcttcag 3465781 cggtgtcatt tacgatagag aaattgatga attagcagca ttggtctatt atccggaaga 3465841 caaactgaaa ttaatcaaac atgactttga tgcgaaagaa gcgttaaacg agtggtataa 3465901 agaaacgatt catcgaatga ttaagctcgt ttcatattgc tcctctaagt atacccgctc 3465961 caaattacgc aaagcactgc ctgcccaatt tgcttatatt acggaggagc tgttatacaa 3466021 aacagaacaa gctggcaaca aggagcaata ttactccgaa atcattgatc agatcattga 3466081 acttggccaa gccgataagc tgatcaccgg ccttgcttac agcgttcagc gattggtggt 3466141 cgaccatctg catgtggtcg gcgatattta tgaccgcggc ccgcagccgg atagaattat 3466201 ggaagaactg atcaactatc attctgtcga tattcagtgg ggaaatcacg atgtcctttg 3466261 gatcggcgcc tattccggtt ccaaagtgtg cctggccaat attatccgca tctgtgcccg 3466321 ctacgacaac ctggatatta ttgaggacgt gtacggcatc aacctgagac cgctgctgaa 3466381 cctggccgaa aaatattatg atgataatcc agcgttccgt ccaaaagcag acgaaaacag 3466441 gccagaggat gagattaagc aaatcacaaa aatccatcaa gcgattgcca tgatccaatt 3466501 caagcttgag agcccgatta tcaagagacg gccgaacttt aatatggaag agcggctgtt 3466561 attagagaaa atagactatg acaaaaatga aatcacgctg aacggaaaaa catatcaact 3466621 ggaaaacacc tgctttgcga cgattaatcc ggagcagcca gatcagctat tagaagaaga 3466681 agcagaagtc atagacaagc tgctattctc tgtccagcat tccgaaaagc tgggccgcca 3466741 tatgaatttt atgatgaaaa aaggcagcct ttatttaaaa tataacggca acctgttgat 3466801 tcacggctgt attccagttg atgaaaacgg caatatggaa acgatgatga ttgaggataa 3466861 accgtatgcg ggccgtgagc tgctcgatgt atttgaacga ttcttgcggg aagcctttgc 3466921 ccacccggaa gaaaccgatg acctggcgac agatatggct tggtatttat ggacaggcga 3466981 atactcctcc ctcttcggaa aacgcgccat gacgacattt gagcgctatt tcatcaaaga 3467041 gaaggaaacg cataaagaga agaaaaaccc gtattattat ttacgagaag acgaggcaac 3467101 ctgccgaaac atcctggcag aattcggcct caatccagat cacggccata tcatcaacgg 3467161 ccatacacct gtaaaagaaa tcgaaggaga agacccaatc aaagcaaacg gaaaaatgat 3467221 cgtcatcgac ggcggcttct ccaaagccta ccaatccaca acaggcatcg ccggctacac 3467281 gctgctatac aactcctacg gcatgcagct cgtcgcccat aaacacttca attccaaggc 3467341 agaagtccta agcaccggaa ccgacgtctt aacggtcaaa cgattagtgg acaaagagct 3467401 tgagcggaag aaagtgaagg aaacgaatgt gggtgaggaa ttgttgcagg aagttgcgat 3467461 tttagagagt ttgcgggagt atcggtatat gaagtgaggg gtgtggggtt cagggatggt 3467521 gatatgctgc tcccctaaaa gtagatagat gaattttaga aaatctgttt gccttgggga 3467581 gttttttcat ggctggacaa ttatactaca aggaagaaat actaatactt atagaatgta 3467641 attgggtaat gattcggaga aagaggttgc gaaataatat ggtattacac tgaaacaatt 3467701 atcaatggag aacatgcacg atatagccgt tctatattct ccctctatta tggcactcat 3467761 tagtagacat aaccgtaaaa aaatgcactc aaaaaaagtc cattctatat aactctcgct 3467821 agggtggacc tttttcaaca ttcaaagtac tagatttttt ctagtgaaag aataagaaaa 3467881 gacataagtt ctattttatc actctgttat aggttaagtt attacggtgt ttcattatat 3467941 actgaattta aacacccttg acattatggg aatttttaaa acaggttaaa aggaagttct 3468001 ataagaactc cctagtttaa tattatttgg tcaaaatcta aaaccaaaaa atctattttt 3468061 atcttcattg tttctatcta attttgcaac aatcatacct ttcgactcta attcttgaag 3468121 gtcatctaat aataattcat ttttatttat tgttacaaaa tattgtccga tcctattctc 3468181 taacagactt gaattgatat gttttaataa tgtacctttt acatgaggat caggattaga 3468241 ataagatccg tcatgaatta aaatattcaa actacactta tttatacacc tgtataaaaa 3468301 ccaagtaaga tcaaatatat ttatcttcat atggagtcta ccatgtgaac gttcatccgg 3468361 tatagaacaa gaaattttga tccttcctgt agttgattgt tttgcgttac ttattctatt 3468421 atcatattca aaatctaaaa atccatgttg gttgtatgta acatccatta gattattaaa 3468481 aagcttcttt aactcactaa ctatagcgct ataagattga aactcatcat aatacattga 3468541 attaactctt aatatttcat gttgaagttc attaatctta tcaaaaatat ggtttttttt 3468601 atcgtagtca ctaattctca atcttacttc cgctaactct atttctttcc ttctttgttc 3468661 ttccatcaca atggaaatat cctcaatgaa attgttactc tttaaaattc tggcacttga 3468721 ttccagttgt tctgttaatc cttgcttttt gatattaagt ttttttaaat cggcttgtat 3468781 tttaacaatt ttatctttaa aataactccc tctactttct accatgaaat tatagaactc 3468841 ttggacttta ttataattct gttttacttc ctctggaaaa aaacctacaa tatcttcata 3468901 gaatttttct atattttcta attctttaat cttagttact tttttattta aatcatctat 3468961 atttctttga tattgtttac aaatatgttc attttcaaat atttcatttt gtattttatt 3469021 aagttcactt ttaatttctg agtacctatt tgtatcatta ttatatttat tggcagtctt 3469081 agtttgatag ataactctat tgtaatcctc tatctcattt attaattcat cttccttaac 3469141 ttttaaatcg ccaatgttaa tattcattga ttcaatcaat tttatttcac tatttaattt 3469201 ttcaatctta tcccgaaaaa cctttatgtt tttttctgta tgagttggta aagtaaaaag 3469261 atagttaagt aatttatatt gttttaaccc tcccctattc ggtaaaacta tatcattaaa 3469321 ccctgtcttt tcgtctctta taatatactc ccttaacgcc gcaaaagtta tatcctcttt 3469381 ctcacccttt aaaatttcct tttcaataaa ttttttatat acacttatac taactttttt 3469441 ccattcctcc aaattaaaag ttaaagaagt atcatgtaat gtataaccat gtttaggaga 3469501 attaaaagat ctagcaagga atacttgatt tccatcaatt tccacattca aaacaataaa 3469561 aacgttttta ttgagaagaa tttcatttgt cgtataaaaa tttgatatag tcttccctag 3469621 taaaaaggag atgcattcaa tcatcgttga cttacctaca ccattagtct cttcatgatc 3469681 ttctctcttt tcaccaagta ttatatttac tcctacagca ttaaatttat actctttcaa 3469741 aatttcttgg gaattgcaaa caaaaagatt ttttataatc ataacaatca ctaactctcc 3469801 gttctgctaa tcatattttg attaaaagaa actttaccta atgaatataa aaaagttaac 3469861 gataaataca gtatccgttc aatattcaaa tttattataa taccttgact cttagcataa 3469921 tcaagaaaaa gttgatcaat atgtttttcc ttctctaaca gttcataaag tatctttgat 3469981 gagtataaaa tattttcttc cacagcatta tatttagtta ataaaaaatg attcatttct 3470041 ggcctctccg ccttttcctt ttttaaagga gaattattca ctagaggaat aagatcattt 3470101 ccaatttgaa tgtttttaaa ctcattttct aataaaacat aagagtattt gagaatattt 3470161 tcagctgttt caattttaag atcaatcatt cttaacactt cttttgttat cattaaaaat 3470221 ctcacattca taaatgcacc aacatgttaa aatcttaatg tattttttcg ttaaagcctt 3470281 tgaatatggt aaaactgaat gacattctag ataaatctca ttaacaattt ttacaaatat 3470341 ctcatctcca ttattatatt gattatgaaa ctctagatat ttgtctacta tcgtctcagc 3470401 aatcaattcc tttttatcag cacttacata cgaagtggaa tccattatat ggtttatcac 3470461 accaaaatac tcagaataac tatcgaattt ccgtttaaaa gtttccccac ttttcatatc 3470521 ataaaatttt ttatctaaac caatttgatt atcaaaatta ctagtaaatg ttttataact 3470581 ttctctatac tcatgaaaat ctataataaa gctcttaaac tcatcttcat caattttatc 3470641 atcgttatct tctatttctt tttcaataag gctctctaat ctattaatct tataatttaa 3470701 cttcccttcc tgtagtctcc ttcctccttg gttgtttttt gaccagtatt tatattcggt 3470761 attccaaatg tagtatgtta cttctgtctc gccattatct aaattcacat ccaccgaaat 3470821 aaattctgga gtagcatact catcctttat aatggctcca cttactaatt ctaagaatgg 3470881 attttcattt gtatttgcag taatattaaa tgaagaatca tgtacatgtc ctgccaaata 3470941 tagatcaata aagtaatcat caaaatgtgc ctttattgat tctctttcgg aagattcaat 3471001 acaacctaac gtatggtgcc caatagctat atttaatacc ttgcccttat ttttctcttt 3471061 gttcatcttc cttattgctt tatataattt catctgtgca gttaataacg ttccttcttc 3471121 acctttttta tctgataaca gacatgtatt tattgataaa acattatact tctccgattg 3471181 atacaaaaaa tgcaaatctt cttccggata tttaacaccc ataaaatctt cataaaaatc 3471241 gaaaaatttc ctttgacctt ccactaatat atttgtagct ttttgatcta gtttatccaa 3471301 catttctgag gggttaggag atttcataat actatcaatc aaaagtgtcc tcgtcatgtc 3471361 tctagatata tcgtgatttc ctggcactaa gtgtacgtta ttcttactta atcccatact 3471421 tttaataatt ccattaagat attctttaac atcttcgtta tacacatcac ctttgtgtgc 3471481 tatatctcca gttaataata aaaaatcaaa atctgactct cttcttaaaa cttctataaa 3471541 atctaataat ttatctctca ttacaatagt gtcataattt tgaaactgaa aatgcaaatc 3471601 agaaatttgt aaaaaacgta ccttcaatac aaacatcctc tcataagtat atttatcccc 3471661 tatatatttc tagaaaactt tttattctat atcatcttta ctctttaata tattaagact 3471721 ctttccacac catcaaataa attataacct aaacataact ctttactcat tttagtattg 3471781 tatttaagtc aaacattgca ttggttgctg aaatattata ttcattgaat tattccatta 3471841 aatagctttt agttgaactt tagtctttct gtaatggtgg agatgctctt acttatgata 3471901 aggctcccca cgattaatcc gaaaagcccg ataaatctgc tccactaaaa taagccgcat 3471961 caactgatga ggaaatgtca tcttcgagaa cgatagcttc tcgtccgctc gcttcatcac 3472021 cgtgtcactc aatccgagtg atccgccgat gacgaaggtg actttgcttt ttccataagt 3472081 agccagctta tctattgtat cggctagttc ttcggatgtt ttcatttttc cttcgatggc 3472141 gagggcgatg acgtgggcgt cggggctgat tttggatagg atgcggtcgc cttctttgtc 3472201 ttttatgatt ttcatgtcct ggtcgcttag gttttccggc gctttttcgt ccgggagttc 3472261 gatgatgtcg atttttgcgt aggccgaaag tcgtttggtg tattcttcaa tgccttgctt 3472321 gaggtatttt tcttttagtt ttccgattgt cacaatattg atattcacag gtcatcccca 3472381 ctttaaaaac aagttattca tatatgttgt ccacaattgt ggatatcttt tctgtatttt 3472441 gtgtaagatc attcgttccc cactatatat actgcggggt ctccacataa ttcacaggct 3472501 gtggataaac tgttagtatg ttcgattttt ctgatttcgg gcggcagctc gtggtcgtct 3472561 atgtacatat ccagcaccgt ttcgatgtgt tcttcacaag aataatacgc ttgtttcatg 3472621 ttcaaatcct ccgatgtttt cttccatttt tacaaatgtt ctcttctcaa tataacctat 3472681 ttattcacat gttagtagtg cttcgggctg agttttatcc acaattcgac aaacaagctg 3472741 ttgatgactc tatttcgctc gtgtgttagt ttggatgtaa ccgatgtgtg gggaggtctg 3472801 catttgcgct ttagatgggt ttggcttttt gtgattatgt tgctgcttgc tgagtgtcag 3472861 ccatcttatt gggtgttgga gaaggatcga atcggtgaag gcagtccaga cttagaaata 3472921 tacgctaatt atctccaaat gcatgatgac gtgaaaggat atcaagtctt caccatatca 3472981 gaaggcaaaa aaatggtcgt cgtgtctctc ggaagcagcg agaaagataa gaagcttgaa 3473041 gtgtcggacg tcaaattctc atctaaagaa acgattgtaa ctgtggagcg aaaacctgct 3473101 cctacggcaa atgagaaaaa cccttttatt ttgattggac tggacaaaat tgaaggggat 3473161 ttaattgttc aagacgaaac aggagatcgc tttgaagaaa cggattacca gcaataaagc 3473221 cggcgttctg agaacgtccg gctttttctt ttacttcaat gtcccatgcg ggtcgatgac 3473281 gaattttttg gctgcgcctt tgtcgaagtc gctgtagcct tttggcgcgt cgtccagaga 3473341 aataacggtg gcattgacgg cttttgcgat ctgcgctctg ccgctcagga tcgctttcat 3473401 caaattgcgg ttgtatgtca tggcgggcgt ttgtccggtg acgaaggtgt gggctttggc 3473461 ccagccgagt ccgaagcgga tttttaatga gcctgttttg gcgtccgcat cctttgcacc 3473521 gggatcttcg gtcacgtata agcctggaat gccaaggctg cctccgacct gggtgacgtc 3473581 catgattgag ttcagcacgg cggctggcgc ttctccttga ttgccgtgcc cagatgcttc 3473641 aaagccgaca cagtccactg cagcatcaac ggttggttca cctagtattt gttcaatttg 3473701 ctcgccgagg cggtcgtgtt tttgcacgtt gaccgtttca cagccgaagc ttctggcctg 3473761 tgccagcctg tcttcgttca gatcgccgac aatcacggta gaggcgccta ggagctgagc 3473821 ggagtgtgca gctgccaagc cgacaggacc cgctccagcg atataaacgg ttgaacctgt 3473881 ttgcacgccc gctgtataag ctccatggaa gccggtcgga aaaatgtcgg acagcatggt 3473941 caaatcgaga atcttttcta gcgcctgttc tttatcaggg aataccaaaa gctgaaaatc 3474001 agcgtatggc accatgacat attcagactg gccgccgacc cagccgccca tatcgacgta 3474061 gccgtaagcc gatcccggcc ggtccggatt gacattcagg cacacatgcg ttttctgcgt 3474121 tttgcacatc acacagcgtc cgcaggcaat attgaaagga acggatacga tatctccttt 3474181 tttgataaat tcaacatcac gccccgtttc aatgacttct cccgtaattt catgcccgag 3474241 caccaagcct tctggcgccg ttgtgcggcc tctgaccata tgctggtcgc ttccgcaaat 3474301 gttggttgta atgactttga gaataacccc atgctcacat tttcgattca cattcgcctt 3474361 cgggacgccg ggcccgtccc tcaagattaa ctccggataa ccgatatcct ccaccgctac 3474421 agtccctttg cctttgtaca caaccgcttt gtttcctgtc aacgccattc ctcccattca 3474481 tgtgtttgga ctctccgtcc ttgaacatga cttcggttcg gcatgactct ttcccttttt 3474541 cacgactgtt ttttctgtat tcttacaaca acaaatatgc caagaaagca tccaataatg 3474601 gttccgccga tgtctaagaa gtcgacttta catccattta acaagaacac agtaatggcc 3474661 gaaaccaggc agatcataac tgccagaaga ataacccgat ttgtctgcat gtaattcctc 3474721 ctttggattc gtttctaaac catacccaaa atcctctgca aacttcggtt caacaaaaaa 3474781 agagacttca caccagtctc ttcataaaca gagatcactc aaaaaatttc ctgagaaata 3474841 atgtggcaac actcgttact aacgcaattg ccgtatacat aacaacccaa aatatgaatg 3474901 agctattccc cgaagctaac gtaactaaca atatcaagct cgtgataaga acgatgagcg 3474961 gtgccaccca aaatctttta aataaaaaat gacccgctat accaaataca cctgcgacga 3475021 tcggaaaacc aaaaacgata aataaaacgg cgatggctcc catactaccc tccttgcctt 3475081 aaaacctctt catcacctca acatcataca gcttcaaatg actcttcggc gtcacgacat 3475141 cctttacctt cccaatctct ttttctttca ttttctttcc ggttttcagg ctgtactgtt 3475201 caatgtaggc aggcttgtga tacgtgtatg tgaagaaata gaggctgctg cctttttggg 3475261 tgatttcttt gaattcggct ttcattttgt ccggggaaag ggtgaagacg atgcttgttt 3475321 ttcctgtctt ggcatcgatt ttgtgtacct ttccgaagcc gtcaatgaaa tacaggttcc 3475381 cgtcataagg gaaaaagctg tttttaaagc tgaagggcat ggagctgtat atcgtttgtt 3475441 cgtcgttttt gtattcggcg atatcgtgca gctctacttc gccgcttttt ttgttgatct 3475501 tgaccatttg atagagatcg tgggcttttt ggccgcgaac cataacatac acagcttggt 3475561 cgtccacggc aagttgggat tcgactgagg ctccttcccg gtactgccat tccgttatgc 3475621 tgagataggt aagcttcttc tgatctgctt gaatctgaag gagctgatag ccttttccgt 3475681 catctgtcgg gacgagtgcg taaatggcgc catcatggaa accggaggct cggatgtagt 3475741 aggggatgac gtcttttttc cactctccgt ccatttggcg gtacagctct gagcggtatc 3475801 cgtctccctt tttgtcgtag ccggagttgt ataaggtgta aaagccgtcc gtgttttgca 3475861 gaaagcccgc gctgtcgcct gtgtgctgat aggttctttt atgggagcgc aggccgtttt 3475921 tgatcgtata aatcgtgttt ttgtcctcca gcatcacgct gtcaccgtga acctttgctg 3475981 agcccagctc aaggcccttc atctgaaagg aagacagcgt cccgtcatgg ctgataaaca 3476041 gggcgtagct tttcccgccg ccaaatgcat cttgatccgc agaggatgag aaatacagca 3476101 ggacttcttt gtcatccagg aaatcgggat ttctgagatc ctgctgactc acggttttat 3476161 ggcttttgag aggagaaatg aagacaaata gtgcgattcc tgcgagaatc agcatggcga 3476221 tggtaatcat ccactttttc atagccttct ccttagtaaa tggtcataat ggttgtcgta 3476281 taagaagaac tagtgatgtc gcgcggatac acgcctaagc ctccgttgct gtctatatca 3476341 atccctgctt tcagcaaaaa ggcagaccat aggagctttg aacagttttt ggcgccgtca 3476401 tggccggtat ttctgttatt gacgaagtta aatgagtatg ggtcgccgac ttttgatacc 3476461 gcccagtcgg cagcagctgt tttttgagat gaggatacgc tgacggtttg cacaatggag 3476521 ttgtcttcca cgtctctggc attatacgcg atctgcctga cgccgtcgct cgggacagat 3476581 tcaacaattt tgtcagcggc ggagtacatg ccgacatggc cgtgattgta gtaggctgtg 3476641 taggagttcg tgtaatagat attgcctttc gcgcttgtcg ggagtttttt cgtgccggac 3476701 gagccgccca tgatagacat gccgctttcc ttggcgagcc ggtccccctc tgctttatca 3476761 gccgtgatct ccttatagaa ctgttttagg ataacgtcct gctttacgtg ctgctgtttg 3476821 gcaatctggc tggcagattt catgatttct tccggtgtcg tgcctggctg cagtgcggcg 3476881 atttcttcag cataatttgt ggtctttacg gctttggcgg gagtaacaaa caggccgccg 3476941 cacattgtga gcgctaccaa aaacatcgac actcgtttct tcaacttcat tacatctcct 3477001 cttttcttgt gagtgtagga aaggtaattt cctcacccac attatattag gaaaataagg 3477061 aaagtaacta ggttatttac agaattttta gaaatcgttt acagaaaaag gcctttatca 3477121 ggcccttttc gttaaagctt cttgctcatc actacgtctg tttcttgaaa tccggtttgc 3477181 tcatatagct ttcgagccgt ctgattatgg gcaaagacat gaagggacag cttgcggatt 3477241 cccatactgc gtgccgcttg atctaatgcc gccaatgctt gctttgcgta gccctttccc 3477301 cgatacggtt catataaccc gaaatcataa ataaacgctt cctgctgcgg atgctccggt 3477361 tcagcatgta tccagagcca gccaacgata tccttttcat tcagcttgag gctccacaaa 3477421 tggtgatggg gtgtttcgag ccctctcgga agcagatcag taaacacctg cttagacaaa 3477481 agctgggcat cttcaggcag ccatgttccc gcttttacct tttcttccgc gtaatgcttt 3477541 gttgtgtacg tgagataaga ccgaaattct tctgtctgca taggggttag cataattgtc 3477601 atatcatctc tccttcatat attgactaga ggattttaca taaaatagaa agaggtgtta 3477661 ctatcagaat aagcaactga gattgataag tcactagaga aaggagtttc acatgaataa 3477721 gatcgcaccc gcagaaatcg ctagcatgct caacgattgg taccttgcca tcaagaaaca 3477781 tgaagttgaa gaatcctccc gtttatttga agaagtgaag cctttattgg atgacatgga 3477841 agaggatcag gaggtgcttg cctacttctc cttattggaa ctgcgccaca aggttttgct 3477901 tcacgaggcg agaggacagg gctttcagca tgaggagcct tctcatatga atgctacgtc 3477961 tgacatgctg aaatattact tttttctgtt tgaaggcatg tatgaggcct ataaaaataa 3478021 ttatgacatt gccattgggc tgtataaaga tgcagagcag tatctcgaca acattcccga 3478081 tccgattgaa aaagccgaat ttcacctgaa ggtcggtaag ctctattata agctgggaca 3478141 aaatattgtg tccctcaatc atacacggca agcagtcaaa acattcagag aagagacaga 3478201 ttataaaaag aagctggctt cagccctgat taccatgtca ggcaatttta cagagatgag 3478261 ccagtttgaa gaagctgagg cttatttgga cgaagcaatt cggatcacga gtgaattaga 3478321 ggatcatttt tttgaagccc agcttttgca taacttcggc cttctacatg cgcaaagcgg 3478381 caaatcagaa gaagcggttt cgaaattaga ggaggctcta cagaacgatg agtatgcccg 3478441 ctccgcctat tattatcatt ctgcctactt gctgatacga gagctgttta agatcaaaaa 3478501 gaaagaacag gccttatctt attaccaaga cgtgaaggaa aaattgactg ctgagccgaa 3478561 tagaatatgt gaggcaaaaa tagacatttt atatgccatt tatgcagaag ggggtcatgc 3478621 ggaaacgttt cacttatgca aacaacatat ggatgacttg ttgtccgaga aagagtatga 3478681 cagtgtaaga gaactttcca ttttggctgg cgaacggtat agggaacttg agctttacaa 3478741 agaagctgcc cacttttttt atgaagcatt acagattgaa gaactgatta aacgaacgga 3478801 ggttatataa atgaaaagat ttctgattgg cgcaggcgtc gcagcggtga ttttatcagg 3478861 ttggtttatt gcggaccatc aaacccactc acaggaaatg aaagtcgctg agaaaatgat 3478921 tggataaatg aaaaaccccc gcgggatgcg ggggttcaat ttaacgaaag aatcctaaaa 3478981 cggtttgtag ttttaggatt ctttcatctt ttcagcgtga ttgaaaaccc ttgaagtcta 3479041 ggaagaacga gcattggagc gcagcgaatg tttggaattc gtgagcaccg aagcgcaggc 3479101 ctgacaacga atgcgagggt ttgtcgacac gctgaaaccc ccgcgggtgc gggggttttc 3479161 ttattacagc agcttcttcc ctaacaggga ttctacgagc tctactgctg ttttgcccgt 3479221 tttgtttttg tgatcaagga tcgggttaac ctcaacgaat tcggctgagg taatgatgcc 3479281 tgcgtcatac agcatttcca tagccaaatg gctctcccgg tagctgatgc cgccgacgac 3479341 aggggttccg acacccggtg cgtcgttcgg atcaagtccg tccagatcaa ggctcagatg 3479401 gacgccatca catgctgata aataatcaag ggtttcttca atgacctttg tcatgccaag 3479461 acgatcgatt tcgtgcattg tgtacacctt catgccgctt tccttaatgt acttgcgctc 3479521 cccttcatca agtgaccggg cgccaatgat gacgacgttt tccggtttga ttttaggcgc 3479581 gtagccttca aggttaacca gtgactcgtg gccaatgcct aggctgaccg cgagcggcat 3479641 gccgtgaata ttgcccgatg gtgaagtttc aagtgtattc aaatcgccgt gcgcgtcata 3479701 ccagatgacg ccgagattat cgtaatgctt cgctgtgcct gcaagcgtgc cgatcgcaat 3479761 actgtggtca ccgcccagga caagcgggaa ttttttctct tcaatgactt tgttgacctt 3479821 ttgcgcgagt ttttcatttc ccgccaaaac ggaattcagg tttttcagtt cctcgtcatt 3479881 tttgattttt tcgcgattga tcggaatgtc accgagatct tcaaccgtat accccatgtc 3479941 tgacagcctc tcgatcagat gagcgtaccg gatggcactc gggcccatat ccactccgcg 3480001 tcgtgcttgt cctaaatcca ttggcattcc aataaccgaa atcgttttat ccatctgtga 3480061 ttccacctca acatttaaga taatgtccta tgcgggttat aacaaagatg acttgcggac 3480121 aacgttttta aagctctagc tgacgatttg cctgctggcg ttttttaatg acgacatgat 3480181 aaatgatgta gcaaatgatc ataaacggta cgccgcaata cagcgcgata cgctgctccg 3480241 gatcaaatgc aagactgatg agcacgaccg tatttaacgt taggccgatc agcggaagca 3480301 ccgggtacag cggtgtttta aatttcaaat cttctatctt cccgccctca cggatatatt 3480361 tgcgtctgaa catgatttgg gaaagcgaga tcgtaatcca gccgacctgc gcgctcatgc 3480421 ccgccaaaga taacagtacc atatatacgg tttcagcctg cgcaaacttt gtcagaagtg 3480481 ataggcaggc cacagccatc gttacgatta acgagtacat cggtacaccg cgctgatttg 3480541 ttttgccaag cgctttgaag gcttgtcctt cattcgccat cgcgtacaga atacgtgttg 3480601 atgcgtataa acctgagttc gcaacagata acagtgcgat taaaataaca aagttcatga 3480661 tatcagctgc atatgggatt ccgatttgct caaatacggc aacaaatgga ctttccacga 3480721 cacccgcctg tttccacgga atcatgccgg caatgacaat gattgaaagc acaaagaaca 3480781 caagcgttct ccatactgtc tgtttgatgg accgcggaat cgttttttca gggtcttcac 3480841 tttctccggc tgcaaccccg atcagctcag tcccctgaaa cgcaaagttc acagtaatca 3480901 tcgtaatcag cattgccttt atgccgttcg gaaataaccc gtcttcataa aaatgtgtca 3480961 aaaacggcgc ctgctctccg cccttcagat caatcaggcc aaacatggca gctccgccga 3481021 gaataataaa taaaaggata atcaaaattt taatgcctga gaaccagaat tcagattccg 3481081 caaaggcttt tgtggtgatc gcatttaaaa taaacatcag tgccgcaaag accagacacc 3481141 agatccacac gtctatatgc ggaaaccagc gttgcatcag ctgccccgct gataaaaatt 3481201 caatggcgca tgtaaccgcc cagccgagcc agtacagcca gccgaacgca aacccgaagg 3481261 ccgggctgat aaatttcgtg gcataggtct ggaaggaccc cgacacagga aaggcgactg 3481321 ccagctctcc taagcagagc atggtcaaaa acatgataaa gccgcccact aaataggaca 3481381 gaaccgcgcc gagcggtccc gcttggttaa tggtaaaccc ggttccaagg aagaaaccgg 3481441 ttccgatcac tccgcccaat gaaatcatga acaaatggcg tgatttcatt gtccgctgga 3481501 gctgatttcc gttatcttgg tttgtattca cattctgcac cccttcagca acttgtattg 3481561 gatctaagct ggaacatctg catggtgcta tcccagtttg ctgtccaaag agtctctatc 3481621 tatttaatat aaaattcact tcttctcata aagatacatt atactaaaat actgtagctg 3481681 agcaaatagg gagtgctgat ttttctgttg taaatttata caaacgaagt gaatatcccg 3481741 ccatggtgcg gatttatgcg tttcgcagca cgtgcttaat tttctctatc gcccaatcca 3481801 agtcctcttt ggaaatgatt aatggcggtg caaaacgaat gactgtatca tgcgtttcct 3481861 tgcataaaag tccctcttcc ttcaaacgct cacaatacgg acgtgccgct tcagtcaatt 3481921 ccacaccgat aaacagccct ctgccgcgga cttctttaat gacagggctg tcaatactct 3481981 caagctcgct tttaaagtat tcaccaagtt caagagaacg atccgccagc ttttcatcct 3482041 ccagcacttc taatgaagcg atagacactg cacatgcaag cgggtttcca ccaaatgttg 3482101 agccgtgtga gccagggtta aacacgccta ggatctcgcg gtccgccgca atgcaagaga 3482161 tcgggaacac accgccgcca agcgctttgc ccaagatata catatccgga acaatgccgt 3482221 cccagtcaca ggcaaacgtc ttgcctgtac gtccgagacc cgtctgaatt tcatccgcaa 3482281 taaacaagac attctcttcc ttacaaatcg ccgccgcttc ctgtaaaaat ccttcaggcg 3482341 gaatcacaat gcccgcttcg ccttgaatcg gttcaaacaa gaatgccgct gtattcggcg 3482401 taatggcctg tcgaagcgct tccacatcgc cgtaaggaat gagtttgatt cctggaagca 3482461 tcgggccgaa tcctcgttta tattcctctt cagaagaaag agataccgcc agcatcgtgc 3482521 ggccgtggaa gttcccgaca catgcgataa tttccgcttg attgtcagct acgcccttca 3482581 cttcatacgc ccagcgtctc gccgctttca ccgcggattc aaccgcttcg gctcctgtat 3482641 tcatcggcag aatcatctct ttgcctgtca gtttagctgt tttttcgtaa aacggcccaa 3482701 gctgatcgtt atgaaacgcg cgtgacgtga gggtgatttt atcagcctga tcctttaatg 3482761 cctgaatgat tttcgggtgt ctgtgcccct ggtttaccgc agagtaagca ctcagcatat 3482821 ccatatattc attgccttcc gggtccttta cccaagcacc cagcgcttca gaaataacaa 3482881 tcgggagcgg gtgataattg ttggctccgt aatgagacgt ctgatcaata atttctttgg 3482941 atttagataa agctgtcata tttgaattcc cccttgtttt ctgtttcaac atgttatcct 3483001 gctttccctt tatataaatg caagttctgt gccaaatcaa gaattcgtgt gttttctaca 3483061 attttcgagg acaaggtgca aaaacattct gatatttcga gcgaaaattt cagcaagtgc 3483121 aaaattcttt tgcatatcct ctccgttttt ttataaaata gaagcaatat taagaaaata 3483181 attgagggag gttcatacag tggtcaaaga cagcgaattc ctcacattgg tttttcagag 3483241 tattttagat gaaatcgatg ttggcctgca cgtggtagac gagcatggaa acacaatcgt 3483301 ttataacaat aaaatgatgc agattgaaga tatggagaag catgacgtct tgaataaaaa 3483361 cctgatggat gtgtttatgt tttcaaagca gcaggacagc acactggtac aggctcttca 3483421 ggaaggcaag acgattaaaa acgtcaaaca gagctatttc aataataaag gccaggaaat 3483481 tacgacgatc aatcatacat atcccatcgt ccaagacggc aaaatcaggg gcgccgttga 3483541 aattgccaag gatgtgacaa agctggaacg gctgatcagg gagaatatga acaaaaaagg 3483601 cagcacaacc tatacgtttg acagtattct cggcaccagt ccggccattc aagacgtcat 3483661 cgaaaacgcc aagcgggcaa cccgtacgtc atcatctgtc cttctagcag gcgaaaccgg 3483721 cacgggaaaa gaactgttcg cgcaaagtat ccataatgga agcgatcgtt ctggcggccc 3483781 gtttatttcg caaaactgcg cggcactgcc agacagcctt gtggaaagca ttttgtttgg 3483841 gacgaaaaaa ggcgcgttta ccggcgctgt cgaccagccc ggcctgtttg aacaagccca 3483901 cggcggcaca ctgctgttag atgaaatcaa ctcgctgaat ctcagccttc aggcgaagct 3483961 gctgcgcgcc cttcaagaac ggaaaatcag gcgcatcggt tcaacaaagg atacaccgat 3484021 tgacgtacgt attattgcca cgatgaatga agacccaatt gatgcaattg caggcgaacg 3484081 aatgcggaag gacttgtatt acaggctgag tgtcgtcaca ctgatcatcc cgccgcttcg 3484141 ggaacgaaaa gaagacattt tgcttctcgc gtcggagttc atccagaaaa acaaccatct 3484201 gttccaaatg aatgttgaac acatcagcga tgacgtgaag caatttttcc tttcttatga 3484261 ctggccggga aatattcgcg agcttgagca tatgatcgaa ggcgcaatga atttcatgac 3484321 ggacgagcaa acgattacgg cttcccatct gccctatcaa taccgcatga aaatcaagcc 3484381 ggctgacatc ccagagccgg aaacaccaag acaccagcca gccgcggact taaaagaaaa 3484441 aatggaaagc ttcgaaaaat atgtgataga gaacgtgtta agaaaacacg gccataacat 3484501 ctcgaaagct gctcaggagc ttggcatcag cagacaaagc ctccaatatc ggctgaagaa 3484561 attttctcac tcgtctaacg aataatccgg agcaggaagc ctgatcagaa aaacagtgcc 3484621 tctgccgatt tcacttttca cttcaatcgt cccattgtga ttgtcgataa tcgatttcgt 3484681 tatggcaagg cctaatcccg aacctccata tttccgggag cgggatgggt ctgccttgta 3484741 aaaccggtca aacactaaaa aacgtcactt cttatgcatt gaagaaagaa aatggcacct 3484801 atgtgtatca cagccagcaa ccacacggta caaaccatta aagtccatgc aaataacgga 3484861 agtatttgca gctaactgcc atttgctgtt tcacgtgtaa catccatctt gtatttttct 3484921 tcatattcga tatatccttt ttcaactgaa cgggcgtgac ccctgttcag ttttttttgc 3484981 atatcaaaac agcctggcaa cgatgccaga ctgcttttat taactgccta attggtctgc 3485041 ggaggacagc ttgatatcaa cagatttttc ttttccgccg cgataaaact tcaccttcac 3485101 ccggtcaccg acttttttct gataaagccg ttttcgcagg tcaacaatat catttacttt 3485161 gtatccgtca aattccgtga tgacatccag ttccttcagc cccgcttttc cggcaggtga 3485221 aaaggcgtct acacccatca caaccgctcc attggtgacg ttcttaggaa gctttaatgt 3485281 ttcatcccaa tgatagcttg cgatgtcact tagcgatttc atctcaatgc caaggaacgg 3485341 gcgtttgacc tttccgtatc tctctaaatc ctctatcaca gggatcacga gcttagacgg 3485401 aatggacagg ccaatccctt caaccgctga ctcggcaatt ttcattgaat tgatgccaat 3485461 gaccttccca tccatattta acaaagcgcc gccgctgttc ccagggttaa tggccgcatc 3485521 tgtttgcagg acttcagcgt tccagtcagg ctgtccatca ccgtttgaat ctactgggat 3485581 cgccctctcc gtacccgaga tgacgccttg tgtgacagag cctgcaaact caaggcctaa 3485641 cgggttcccg atcgcaataa ccggctcccc agacttcact ttatctgaat ttccgaaatc 3485701 agcgactgct ttaatcttat cgcttttcac ccgtaaaacg gcaaggtcca tcagctggtc 3485761 gctgccgaca agatcagctg atacacgtga gccgtctttc aagctgattt caatttggga 3485821 agcgccttcg atgacatgat ggttggtcac gacataagcg gaatggtcat ttttcttata 3485881 gatgacgcca gagccgctcc cagcctcgcc gctctctccc caaatatctg atttttggat 3485941 gttcacaaca ccgacaacgg cgggcgacat attgctgaca atcttggtga cggcattgtt 3486001 gacactgaca ttcaccgtcc tgattgattc ccggccattg ttgttttgct gctgatctaa 3486061 ggcgcctgta tccagccctt catttgaaag gtacggcatg ataaacgcca ttaatacggc 3486121 accgacaatc acgccaatca gactcgaaag aaaatatcct tttttgcttc tctttggctg 3486181 ttcaggagta gtatgttctt cctcacgttc gtaatccacc atattccatc ctttccaaga 3486241 acgttaatat ggttatattg tgggttagaa actcctagaa tagtcatgat ttacatagaa 3486301 aaattataca gcgcaaagcg gagtggcctt cttcggatcg gtgtcgtata agtcaaatgt 3486361 ctcacccgtc acaaatcctt tagaagccaa tgtctgctgc acagacattc ttgccagctc 3486421 cttcatgttg ttgtcctggc tcaaatgcgc caggtaaata cgagacgtct catcgccaat 3486481 gacatccgtc atcgccaagg cagcatcttc atttgacacg tgcccgacgt cacttaaaat 3486541 ccgccgctta atgctccatg ggtatcttcc catttgcagc ataccgacat cgtgattgct 3486601 ttcaaacaca aatacattcg ctgaacggat aatgcctttc atccggtcgc tgacatatcc 3486661 cgtatctgtc attaacgcga gctttcggcc gctataatgg aatacataaa acatcggttc 3486721 cgccgcatcg tgggaaacgc caaacgattc aacatcaagt ccgccgaacg acttcaccgt 3486781 ctccattgga aatacaaact tttgatcggt gtcaattttg ccgatttgat tctccatcgc 3486841 tttccaagtc ttctcattcg catagatcgg aagcttgtac tttctggcga cgacaccaag 3486901 gcccttaata tggtcactat gctcatgcgt cacaaaaatg ccgtctacat catccagctt 3486961 acgcccgatc tgcgccatca gcccatccat ggcttttccg ctcaaaccgg cgtccactaa 3487021 aaatgcgtga tcctctgttt cgaggtaaaa cgcatttccc gtactcccgc tcgcaagtac 3487081 gctaaattgc aagctcatgt ttgtctcact ccattatttt cattgatctg tatctaaaat 3487141 cgtactctcc aaagcattca cagtaaaata ctcttgtact gtctttttct caccgttcac 3487201 ttttttctcg tactcgaccg taattctcca taccggcgcc agcacctgcg tacttgtcag 3487261 cggatattgt gctacatagc cgaatttaca gctcttcaca gtgctgtatt cttttaattg 3487321 attttgatag tacaatagct caaccgcatc catttcagta attaagcttt ctttctggat 3487381 ttgcttgaag gtctcaagcg tagtctggtc gtatgacaca acctcgtttt taccgtttaa 3487441 gtgcagcacc acttgcccga tcatattaga gggattgtcg gtcttttggt aaatataatg 3487501 accttcgtac gtttggaaga aaataatttc tttcttcgat ttatcaacct tccaaagctt 3487561 atatttttcg ccatcttgaa ttttcgaaga aacaagtgcc tgagcatcgt cctcgatatc 3487621 cttctttgat agtgcgattg gatttgcaaa cttcattttc aggctcgtta ctttatgatc 3487681 atcactaggc atgtccatca aaggcttttg atccttcagc gcctcaattt cctccttgga 3487741 gaaagacttt tgatttgccg tgatccgata gccttctgtt gcttccttat tcaagccttc 3487801 atacgtgata tgatcggcct tcatgtcatg ctcgacatca tttttaatga cttcatattc 3487861 tttgccggta gcctgccatt tttgaaaaaa ctgatagcct aagaaaatat ctaaaatgag 3487921 gaaggcaacg atgaagattg attttgtctt attccactcc actgttagcc ccctccttcc 3487981 tcaataaatc ctttgtaatc ggcacaattt ttccatttac tttcatcgcc caaaccggtt 3488041 ccagttcaac gagaggatca tcgttggttg atgttgatac caattgataa gcaaggaaga 3488101 tctgatcaat tttgtccgta tcataagcgg tttgtttcga aagcagcatc ttcacttcgc 3488161 tgccgcccat gagctctgtt tcacttgttt taatcggatt cgttccgaga ctgtaattcg 3488221 gccgcttata gctgagaata tcatcattcg cccattgcac cgtaatcgcc gatgtcgccc 3488281 cgaaaggttt ggcggtgctg ttaatgaccg ggatctgatc cataaaaata tagaagctca 3488341 actgctggct gtcattgata ttgaaaaatt gatagtgatc cgtccagctt ccggtatcct 3488401 caaggtattt ttggctcttt ttgattaatt cacctgtttg ataggatgtg ctctgcacca 3488461 aattgcgctg ctgaaattgc acctgtctct ggcttagatt cacatctaac cggctgatcc 3488521 catctgtcag cacatttctg ttggtgtaat tcgaatcttc tcttacaatg ctcggatcac 3488581 taaacaaagc ctgcttaaag gtatttgttt taatcgattc tgtgacaaat tcttttttgt 3488641 ccatcgtaag cggtttgttc ggcagcaaga actctttctt tgagccaatg gagaacaaac 3488701 tgaacgccgg catatttgat tgcctgtttt tcaagtcgtt cataatgttc cggtagtttg 3488761 ctgattcaac cgtcacttca agaatgagct gcttgctgta tgacaccaaa tagattttct 3488821 tgttcgcttt tgtttcattg aacgggatca gaatatggtc aaacgaactg tattcaaacg 3488881 actgattaga ccatttaaac agcgtttgga aaatatcaat cgggatcgta tcgctgaatt 3488941 gcaagtcaag cttggcttca gaaccgccta ttccataaaa ccagcttttg aatccagcct 3489001 tgtcatactg atccgaaata tctttaattc ctttcacatc ccaatgcggc aagtcagacc 3489061 aaatttcttc atagagggca ttgtcatcca ctttgtaatg agcgccgtca tcatggataa 3489121 acatgtccct tggccttacc gtttcagaca gcttttgggt ggttttttcg attttatgtt 3489181 tcacacgaac agtagactct gttgaggatg agccttcaga aaagtttggc tggaacgtcc 3489241 atatccccca tgtaaaaaca agactgatga cgacgagtac cgtaagtaat atcgttttta 3489301 tattttcacg cttcatccca atcatcctct tgttcctctt tatatggaag agtaaatgta 3489361 atcgtcgtgc cttttccttc tatgctgtcc gcccaaatat ctccaccgtg cgcctgtacc 3489421 atttccttgg caatcgccaa tcccagaccg gtgccgccaa gctttctcgt tctcgcttta 3489481 tccaccctgt agaagcggtc aaagactttt tcgacatctt ttttcggaat gccgatccct 3489541 tcatccttca cgctgatata gagaagttct tcctcttcat tgacatcaat cgagaacgtg 3489601 acatgtccgc cttccggtga atattttaaa gcgttagaaa taatattatc gagcacctgc 3489661 gttattttat cctggtcaat ctcgacatac agatctctgt ccggcagatt gcggataaac 3489721 tccacatgct gctcttttgt catttcaaaa cggtcaataa taagtgacat aaaccggaca 3489781 atctgaatcc attcccggtt aaattgataa tctttactgt caaatttcga cagctgaagc 3489841 agatcattga caagccggat catacgctct gtttcatttt gcgtcaccat taagaagcgc 3489901 ggagcaatgt ctttattttc ccacgcgcct tcagctaacg cttctaaata gctgcgcatt 3489961 gtcgtaagcg gcgtccgcag ctcatgtgat acattcgcaa cgaattctct gcgttcctga 3490021 tccattttct cttgttcggt tacatcgtaa atgacagcga ttaaaccatc aattttgccg 3490081 tgttcccttt gaatcacaga gaaattcacg cgaagcaccg ttaattcatc atcgcgctca 3490141 atttcaagca gcatagaatc ctgctgttcc actaaatctt caaaagtata attctcttga 3490201 agccccagca aactcgtaat cggcatttct aaggctgttt cacgtgaaac gttcaacagt 3490261 tccagcgccg ggctgtttaa gagaataatc gctccgtttc ggtttgtggc gataacgccg 3490321 tctgtcatat aagcaatgac agaggctagc tttctgcgtt ctccttcagt catcgcctgg 3490381 gcatcttcaa gctctctcgt taagtggtta aacgttgtgg ccagctgccc aatttcatca 3490441 tgtccatact ttttaacctt cctcgagaaa ttccctttcg caagctccat cgcctgcttt 3490501 cgcatatctg aaagcgggtg ggtaatggtt cttgccagaa aaataccgag aagagccgtc 3490561 aaaacaagtg ccaaacctgt gccggacgcc agtatcgtgt tgatcgtctt catttgatta 3490621 aagacatctt ccatactcgc gacaacgtag atcgcgccca caacctcttg gttttcagtc 3490681 atgacgggct tcgcggaaat aagaactctg attttgcttt tcgggtcata atattttctt 3490741 aaatacgact gtttggtaga aaagattctt ttgaaaatca gatcggtcgt ttgtttccca 3490801 gccacttcct caccgtacgg ctttgaagaa ccgaccactt catagctttt atctacaaag 3490861 ctaatttccc gaacctcatc acttttcgtg aagtcattca aaatacggct gacgtcatcc 3490921 tttatgacgg tactgtcgtt atcgctctta tattcttgtt cgatataata agaaaggttg 3490981 tcgattcgct gattcagcga ttgttcataa gagctgatca gcgacttctc tacctgattg 3491041 acaaaataca caccaatgat ttgcatggca atgataatca aaagcacata aatcaaggta 3491101 atcttaaatt ggatcgaccg aaaaaaacca accttattca tatgggcatt agtcctgttc 3491161 tgggtttctc aagtaataac ctacaccacg gcgtgtgacg atccaatttg gatggctcgg 3491221 gttgtcctcg attttttcac gaagccggcg gactgttacg tcaaccgttc tgacatcgcc 3491281 gaagtaatca tagccccaaa cggtttgaag caaatgttca cgggtcatca cttgtccgat 3491341 atgttttgct aaataatgaa gcaattcgaa ctcacgatga gtcaattcga ttgtttcgtc 3491401 tcgttttgat acaacgtacg cgtcagggaa gatgacgaga gagccgatat gaatctcgtt 3491461 agaggaaggc tcttcctccg caggcgctgt tgtcagctgg cggcgcaggt tcgcttttac 3491521 acgcgccaag agctcgcgtg tgctgaatgg ttttgtgaca tagtcatcag caccgatttc 3491581 aagcccgata accttgtcaa tttctgaatc cttagccgtc agcataatga ttggcatatc 3491641 gtatttcttt ctgacttcgc ggcatacttc aacgccgtct ttatttggga gcataatatc 3491701 taaaagaatt aaatcaggct gaagctcttc taccatttca acggcttcgt ttccgtcgtg 3491761 ggcacagtgc acttcatagc cttcttttct taagttaaat tccaatatat ctgcaatcgg 3491821 tttttcatca tctactacaa ggatcttttt atccatcatt ttgattttcc tcctgccgaa 3491881 tgacttcatt tcatctatat aacattcgtt tcatcactta tggcccatgt aaagaatggg 3491941 tccttgtcta ttataacggt ttaaggtcaa aagataaaaa aaataaaggt ttagaaaaaa 3492001 aacacatgtt tcacctttat cgccagttgt ttatctattg tcatgctggt caactttttt 3492061 taaaaaagat aactttattg aaacctcccc tcaccggagt gcgtctttat caatgacgtc 3492121 ttcttctttg aaccggccgc agggccggtt ctcccttttt cttctattat aacactcctc 3492181 atgtttgcct ttttcctaaa agaaaaaacg cacctacgat tgcagatgcg tttggtaagt 3492241 ggctcgggac ggaatcgaac cgccgacaca cggattttca gtccgttgct ctaccaactg 3492301 agctaccgag ccaaatgttt tatttttctc tactaagtaa agtaaaatgg cggtccggac 3492361 gggactcgaa cccgcgacct cctgcgtgac aggcaggcat tctaaccaac tgaactaccg 3492421 gaccttacag taattgcccg gagagctgtc gtgtcagctc tcacagacaa ataaggaatt 3492481 tagcaataac gctaaagtaa atcaatgacc cgtacgggat tcgaacccgt gttaccgccg 3492541 tgaaagggcg gtgtcttaac cgcttgacca acgggccttc acgaaatggt gagccatgaa 3492601 ggactcgaac cttcgaccct ctgattaaaa gtcagatgct ctaccaactg agctaatggc 3492661 tcttaaagat gtcggaattt ctatagagca aacgacttaa atctagttct catcttgtac 3492721 tctattgaag cagtttccgt aacaacgaga tttataatat cacgaacaaa tagaagtggc 3492781 aataactttt ttggtttttt ttcatatttt tttctcagac caacttatat gcggctttca 3492841 aacaaaaaac aagcccctta aataggggct tgcagacata ttctatttag ttcgcacggt 3492901 acacactgcg aaggacattt gtttgtgagc ggtctggacc gacagagaaa atagaaagcg 3492961 gaatgcctgt cagctgagac acacgctcaa gataatggcg cgcattttcc ggaagctcgc 3493021 tcaagctctt cgcacctgta atatcctcag tccagcccgg catttcttca tataccggct 3493081 cacattcagc aagtgcctta agacttgctg ggaattcttc aatgatttcg cctttgtagc 3493141 ggtacgccac acagattttc aacgtttcaa ttcctgctag gacgtcaatt gagttcagag 3493201 aaagatctgt aattccgctc acacggcggg cgtggcggac aacaacgctg tcaaaccagc 3493261 cgacacggcg cgggcggcct gttgttgttc catattcgcg tccgacttca cggatttgat 3493321 cgccgatttc atctttcagc tcagtcggaa aaggaccgtc gccgacacga gtcgtatatg 3493381 cttttgatac accgacaacg tgcttgattt tggtcgggcc gacaccagaa ccgatcgtga 3493441 caccgccggc aaccgggtta gatgacgtaa caaacgggta tgttccttgg tcgatatcga 3493501 gcataacccc ttgtgcgcct tcaaataata cacggcgccc ttcatcaaga gcatcgttta 3493561 agacaacaga tgtatcgcaa acatactttt taatctgctg tccgtactca taatattcgt 3493621 ctaagatatc ctcaagttta aacccttctg tctcgtacat tttctcgaga agacggtttt 3493681 tttcttcaag attgcgctca agcttttccg caaacgcgtc acggtctaac agatccgcga 3493741 tgcgaattcc gatgcgggct gctttatcca tgtaagcagg gccgattcct tttttcgttg 3493801 tgccgatctt gttagcccct ttacgctctt cttccacttc atccaatttc aaatgatacg 3493861 gcagaatgac gtgagctctg ttgctgattc tcaggttatc tgtactcacg ttgcgctcat 3493921 gaagatacgc aagctctgtg actaatgctt tcggatctac aaccattccg tttccgatta 3493981 cacacgtttt atccttatag aaaattccag acgggattaa gtgaagctta tatgtgattc 3494041 cgtcaaactt gattgtatgc cctgcgttat ttccgccttg ataacgggcg atcacttctg 3494101 cattttctga taggaaatct gtaattttac cttttccttc atcgccccat tgcgtaccta 3494161 ctacaactac tgaagacatg tccgtgcacc tccgttaacc tttcaaaacg attctattca 3494221 aacaaatcaa gtttatcagt gaagaaacag aaagtcaatt gtaaatccga acattaattt 3494281 attgtaaatc tatattcgtt cgcttccatt cgttttataa gcgttttctc actgctttgt 3494341 cataaaaagc ttgcgaaact ttcatccttt agcataagaa agaatcactt gcctgatatc 3494401 ccttttgaat tcataaaaac gatccgccag ccgtccgggt cctctatcgt cacgccccca 3494461 ttgctccagt acgggttctc tgattcgacc tcttgatagc ccatgtgctt tagctttgaa 3494521 gtgatcgctg ccagttcaac tgcattcggc acataaaaaa caagaaggct gtcgggatgg 3494581 ggaacggggg cagtgcttcc cccttcatac tgggtgaatt ccaaatgata atcggcatga 3494641 ggaaggccga acatgacacc gtcatacccg ttatgctgtg aaaattctcc tattcgtttc 3494701 aaacacagtc cctcttcgta aaaacgaata atctcatcaa gctggcccgt aggacgcgca 3494761 attcggattt gtgctgcttg aaaagacgaa aaacgttttc ccatattgtt accatctcct 3494821 ttttgcacca ttttattaaa acgctttcaa tttttcatcc gctgagcgaa cgtcatttct 3494881 tccatctttc gaatgaaaaa aaccccaaga gcagctcttg gggcttatgc gccgggcgga 3494941 acgcctgcgt catcaaaacg ccgttccagg ttgacgaatt tgttgtattc ttttacgaac 3495001 gcaagagaca cggttcctac cgggccgtta cgctgtttgg cgataataat ttcgataata 3495061 tttttattct cggtttcttt gtcatagtag tcatcacgat aaaggaacgc gacaatatcc 3495121 gcgtcctgct cgatacttcc tgattcccgg atatcagaca tcatcggacg tttatcctga 3495181 cgctgctcaa cacccctgga aagctgagaa agcgcgataa cagggacttg cagctccctc 3495241 gcaatcgact tcagttcacg ggaaatttca gatacttcct gctgacggtt gtcctttgaa 3495301 cgaccgcttc cctgaatcaa ttgcaggtaa tcgatcaaaa tcatgcccag cccgctttcc 3495361 tgcttcaagc ggcggcactt ggcacggatt tcactcactc gaatacccgg tgtatcatcg 3495421 atgtaaatcc cgctgttcga taggcttccc attgccatcg tcagcttgcc ccaatcctct 3495481 tcggtcaggt tacctgtacg gagattctgg gcattgatat ttccctcggc acagagcata 3495541 cgcataacga gctgctcggc acccatctca agactgaaaa tcgctacgct ctcatcggtc 3495601 ttcgtcgcca cgttttgtgc gatgttcagg gcaaaggctg ttttccctac tgaaggacgg 3495661 gcagccacaa tgatcaagtc gttgcgctgg aaacccgcag tcatccggtc aagctccgta 3495721 aaccctgttg gaattcccgt gatatcacct tttcgattgt gaagctgttc gatattatca 3495781 taggtctgga caaggacgtc cttaatattt tggaaggcac tcgtgttttt gcgctgtgcc 3495841 acttccataa tcgttttttc cgcttcactg agtaaatcct cgacctcatc ctcacgggta 3495901 tacccgtctt gagcaatcgt tgtcgcagtt ctgattaatc ggcgaagaat cgatttttcc 3495961 tcaacgattt tcgcgtaata ttctatgtta gccgctgtcg gcaccgagtt tgcgatatct 3496021 gtcaaatatg aaataccgcc tacttcttcc agcaggtctg tgttcgcaag ctctgatgta 3496081 actgtcacca gatcaaccgg ttcacctcgg tcaccgagca ccagcatcgc attatagatt 3496141 ttttggtggg acattctata gaaatcatct ggaatcaata cttctgaagc cagtgttaaa 3496201 gcagacggct gtaaaaaaat agcgcctaac acggcttgtt cggcttctat attttgcgga 3496261 ggaagccggt cattcagaag gtctgtcatg ctaagcaccg tcctctcatt aaaaaatctc 3496321 caacctccat tctaccattt ctacagaaaa aaaatagaaa aattgtctgt ttcctgtttt 3496381 tttcagttag cagattggat cgtttcggac agtaacaagg cgggaaaaat gcaataaaac 3496441 ataagggagg aatgaaagat gataaagaaa tatgcgatta cacctaatgt tgatgcggac 3496501 ggctggttta ttgaggtgga gaatgtagcg ccgacagctt tgtatacgtc taaagacgcc 3496561 gctattgaaa aggccaaaca ggtggctaag gaaaacagtc cgtctaagct tgtaatttat 3496621 gaccagttta aaaatgtgga agaagaacac tcattttaat gaatgaaagc cttcgctgca 3496681 gcgagggttt tttagcggtt atcggtttat ttcatccatt ggatgcctat gtgcatcatc 3496741 aaatctgccg ctttttgata cagatcccac tccccgatcg aagcaaattt ccccatcagc 3496801 tcctgaagct ttaacctcat tgctatatat tcttcgaaag tgacagcttt ttcagtgtct 3496861 atttggtgtt ccttcagcat ttgttttaat aaggataacg gtgcgtgcat aagaaccctc 3496921 cttacctctt ttataacggt cattttccga ttgctctatt cctttgtgac atcttcttac 3496981 atttcacatc tgattcttgt acaatggaca gaagagagga gggatctttt gtgagacctt 3497041 tgcaaatttc tgccgaaact gcacaaaagc ttgcagagtc cttgaatctg ccgcttgaac 3497101 agatcatgca tatgcctcag catattctgc ttgccaaaat ggctgaactg caaaaagagg 3497161 acaaatcata gccttcattc acatacttgc ttacctgttt cgggataata tcatgtatat 3497221 gttagaaaag aggagtaact gctttgccac atccacataa taaaaaaatc caatcatttt 3497281 ggctgatcac cggcattatc tttatcgcct ttaacttacg gcccgcgatc acttcagtcg 3497341 gtccggtcat cagctctatc cgggcagagc tgcacatgtc caatggggca gccggttttt 3497401 tgaccgcact gccgctgctt tcgtttgcag ttctttctcc gcttgcacct aagcttggac 3497461 agcgcctcgg taatgagcga actttatggc taggtctcgt gatactgctg atcggtgttc 3497521 tgactcgttc taccggctat actgccgctt tgtttttcgg aacagcactt atcggcgtcg 3497581 ggattgcgat tggtaacgta cttttgccaa gcttaatcaa acataaatac cctgaaaagc 3497641 cagggatcat gatcagcctg tatacgacat caatgaatat attcgcagct ttagcatcgg 3497701 gtgtcagcgt tcctttagcg acccagatga atggcggatg gaaacaagcc tttctcttat 3497761 ggggcgggct ggctttactt gcattgctaa tctggatacc tcagctgcgc catcgagata 3497821 cggcaaacca gacaatgaag ctgcaatcca gttccatttg ggcttccaaa atggcatggt 3497881 atgtcaccat ctttatgggc ctgcaatcgt ttttatttta cagcagcatc gcttggtttc 3497941 ctgaaattct ccgttcacac gggattgata cggcaacagc cggatggatg gtatcactca 3498001 tgcaatttgc gagtctgcct tccacttttc tgacgccagt tttagctgac cgtgtgaaac 3498061 agcagcgcgg tatcgttgcg gcgctggcct cagtttatct gatcggcctt tgcggattat 3498121 tagcgggcgg aagccataca ttgcttgcca tctggatgat cattatcggt atcggacaag 3498181 gctccagcat tagtctggcc cttactttga ttggtctccg cagtgaaaat gcccaacagg 3498241 ccgctgcgct gtcaggcatg tctcagtcat tcggctacct gctggcagca gtcgggccaa 3498301 tctttgtcgg ctatctcttt gaccagacgc attcttggac gatgccgatt gtgcttctca 3498361 ttgctgccct gatcgtaatg ggagcagccg gacagggagc cggacgagat cgatacattt 3498421 tccagtcaga aaaacaaaga aattcagcat aaagcgggga agatatctcc gcttttttct 3498481 ttgaatattt atggtttatt cataagtttt tcatatttgt tttttacaat gagacaccat 3498541 aaagaggtga aaaacgatga aaaccaaacg attcgacgca gcccttattc ttattttgct 3498601 agcagcagct tttttgaata cgtatcacat ttggcaggat gatacagcaa accagtacta 3498661 tttggcggct gtaaaaagca tgacgcaaag cttccataac tttttttatg cgtcatttga 3498721 cccttctgga tttgtgacag tagataagcc tcctgtcgtg ttatggattc aaacgatttt 3498781 cgcactgatt ttcggtgttc acacgtggag tgtcatcatt ccccaggctc ttgccggagt 3498841 tggatctgtc ttccttctct acagaatggt taagccgact tttggagttg gagcggcccg 3498901 cattgccgca cttgtcatgg cactgacccc tatcgcagta gctgtcagcc ggacaaacaa 3498961 tatcgacagc atgcttgttt ttaccttatt gctcggttca acttgtctgc ttagggcagt 3499021 aaaacaaggc aagctggttt ggctgctgac ggcatttgcc ctgattgggc tcgcctttaa 3499081 tatgaagatg atgcaagcgt ttatggtatt gcctgcattt gtgttattct acctgattgc 3499141 atctcgggtt tctctgaaga aaaaaatcgg gtccctgctt ctgtctcttg tccttctgac 3499201 aggcctttca ctctcatggg cgattgcagt ggattcagcc tcttcctcaa gccggcctta 3499261 tgtaggaagc agccagacta actcagtgct agaactggcc tttggctaca acggcacaga 3499321 gcgtctgttt gggcaaacta cgggccttgc aaagggtgat atgaatgctg ctggcggagg 3499381 gaacatgcag aatcaagaca acatgcaagc gccaaatggc aacggttcat ctttttctca 3499441 gaacggtaat caatcattcg gaaaccattc acaggcgcct cagccgccta acggacaaac 3499501 cggcgctctc aatggaggcg gaggcacacc tcccacaggt ggcaacggac ctggaaatgg 3499561 agggcctggc ggcggaggcg gaaaaagcgt gaatatgttc ggcaccggtg atcctggacc 3499621 gcttcgtctc ttccaatcag cactttccgg ccaaatcagc tggatgcttc cattctcatt 3499681 gatcggatta ctgggcgcaa tcatcagctg gtaccgtgat cgccgcggac atgctgctaa 3499741 aatgaaagaa acgctattct gggcggcttg gcttgttccc gtggctggtt tcttcagcat 3499801 cgcaggattc ttccaccagt attatttgat tatgctggca ccgccgattg ccgccctttc 3499861 tggtatcgga tggtatacga tgcaccgctt atacaaaaat aataaagact ggtccagcta 3499921 tcttctgccg gcagccgtct tgatcacagc cgtgtttcag gtgtatattc tgagcgctta 3499981 tacaagccaa atcggcagtg tatggatgta tgtcctgggg ctcttaggac tgggcatcac 3500041 ccttgcactt ctgatgctta aacgcagcca tccgttcagt aagctgctga ccatcatcag 3500101 cttgtgcgtt ctgcttctca caccagttta ctggtcagca acgccgcttc tatacggtgg 3500161 caacagcgtc cttcctgaat ccggcccgca gctcaaaggc tcagcaaacg gcgggaacat 3500221 gttctcttca gaggtcgaca gcgggctcct gtcctatctg agaaaacaca ataccggcga 3500281 agagtattta tttgctactt tgacaaccgt aacagctgcg ccatacatca tttacgaaaa 3500341 tgaatctgtt atggcaatgg gcgggtttaa cggcacggat cccattctga ctgtgtcgga 3500401 actgaaaaaa ctgatcaaag aaggcaaagt gaaatacttc cttctgtcag aaaacaactc 3500461 aggcaacagc gaacttgttt cctggattaa gaaaaacgga aaagaaataa catctgacga 3500521 gtacagcggt tcctccagca gcacaaacag cgtgcaggga atgcgaagag gacctggcgg 3500581 agaaagccag caaactcttt atctcgtgga ataaaaaaag aggcttggat gaatccaagc 3500641 ctcttttcta ttaagcttct tcttttacat gtacctttaa cacagcctgc acttcaggat 3500701 gcagcttcac aggcacgttt gtatatccta atgcacgaat gccgtccggc agttcaagct 3500761 tccgcttatc tactttaatg ttatggtctt tttggagctg ttcagtgatt tgcttgcttg 3500821 tcactgaacc aaataaacgg ccgccctcac ctgattttgc gctaagctca acagtcagtt 3500881 tttctaatgt ctctttcaag ctcttagcct gctcaagctc agcaatggct tcttttttct 3500941 ctttctgctt ttgtccgttt aacgcgctga tgtttgacgc gttcgcttca accgcgaggc 3501001 cttttttaat tagaaagtta tgcgcataac cgtctgctac gtttttgact tcgccttttt 3501061 ttccttttcc ttttacatct tgtaagaaaa taaccttcat ctctgtacgc ctccctcaaa 3501121 atactcatct atggcgtgct tcagccgttc cagcgcttca gaaactgaaa tgccggacaa 3501181 ctgagtcgcc gcatttgtta aatgccctcc gccttccagg gcctccatga tgatctgaac 3501241 atttacctcg ccaagcgacc gagcactgat acaaaccgtt tgttcatccc gtctcgccac 3501301 cgcaaatgaa gcctcaacct cactcatcga tagcagcgaa tcggcagcct gcgcaatcag 3501361 cacttgatcg aagtattcct cttcattttc aggaagagaa gcaatcgcaa tgttatcttt 3501421 atagaggacc gtatgctgga tcagcttcgc ccgtttaata taggaatcaa cggtttcttt 3501481 cagaaacttc tgcaccagca ccgtgtcggc gccttttgcc cttaaataag aagccgcatc 3501541 gaaagtccgc gagcccgtgc ggagagaaaa gctctttgta tccactatta taccagctaa 3501601 tagggctgtt gcttcaatca tattgatttt taagcgcttc ggctgatatt caagcagctc 3501661 tgtcaccaat tccgctgtgg aagaagcgta tggttccata taaacgagca gcggatctct 3501721 gataaactcc tcacctcttc ggtgatggtc gatgaccacg atatgttcaa ttttattgac 3501781 cagccgttcc tccatgacga gtgacggctt atgtgtatca acgatcacaa gcagtgtgtc 3501841 atcattggaa atctccattg cttcttcagg cgtaataaat cttgaccaca gttcttcata 3501901 ttttttgatt tccccaatca aacgctgcac acttgatccg atttggtttg ggtcaatcac 3501961 gataaaacca tctttgttat ttgcctgagc cacctttaaa atcccgatcg ctgcgccgat 3502021 agaatccatg tcggggaatt tatgccccat gataatcaca ttgctgcttt cggtgacgat 3502081 ttcctttaag gcgtgagaaa tcacgcgggc ccgcaccctt gttcgtttct ccattgggtt 3502141 tgttttaccg ccgtaaaact tcaccttgcc gtttggcagc ttaatggcta cctggtctcc 3502201 gccgcgtccc agtgctaagt ccaagctgga ttgcgccaaa tcgccaagtt ctttcaggga 3502261 agagactgaa gccccgacac cgacgcttaa cgtcagcgct acaccgtcaa acgaggtttt 3502321 ttcccgcact tcatcaagaa tcgaaaactt cgaattttcg agttcagtta agatatgttc 3502381 attaagtaca gcaataaagc gttctgaaga cgtccttttc aagaagatcc cgtactcctg 3502441 cgcccaagcg ttcagcaaag atgtcacctg gctgttcatc gtgcttctcg tctggtcatc 3502501 caatccttgt gtcacatcat catagttatc aaggaaaata tatgccagga cggttctttc 3502561 gttttcatat agcttttcaa tctggatttg ttctgttaca tcaaagaaat ataagagacg 3502621 ctcatcccgt ttgatgacaa ccctaaactt gcggtcattc aatgtaaccg tttccgattc 3502681 cacctcttgt ttgataagcg gcactaccga ttcacaagta tcgtaaagtg atctccccac 3502741 taaagtgctt tcattaaaac aagaggaaag aaacggattt gcccattcta tataatattg 3502801 gtcattaaaa agcatgattc caatcggcat ttccatcaat gcctcttcac cgactttttt 3502861 caacctgtag gacaacgtag aaatataagc atcaatctct tgtcgaataa gagaatcagc 3502921 acgcttaata aaaaacaaaa taactgccag cagcagcact tcgacggttc ctaatatcca 3502981 gttaaaataa aagctgatga ggattgtaat aattgacaga gcaatcaatg catagatggg 3503041 ataccgaaac agcggttttt cataaaagct tggcatttct atcactcccc accatgtgag 3503101 taaaactcat gttcacttca ccttattcct tatatgaaag cccatatcta aaacgcctaa 3503161 aatgcgaatg gccgccatga agaccggatg cacaaaccca agtatgacag caatcacagc 3503221 cgcagccttt ggatattgtt tcttatggca atagaaaaag ataaatgata aaccttggat 3503281 gaaaatcaga aacccgagta taaactcccc atttaaagcg atagagtaca gcatttggcc 3503341 tttttctaaa ggcaaaaatg aaagcatgac aataatcaaa tacagtacta caacactttg 3503401 cggaaacttc aactctctaa aaggctttag attaggaata tcgggggaga atcgccttaa 3503461 gagcggctta gcgataaggt aactgaggaa agaaaaaata actcctacca tcacaatagc 3503521 tgttggaaaa agatattgaa cgatacccaa ttgttcttcc atcagtttta attgcttctc 3503581 aaactgccca gcattgcccg actgcttcgc tacagtttct acaatatcaa gagattgccg 3503641 gtattgtgtc attgcctcat caatgatatt gatacccaaa aactgaatgc ttatcacaaa 3503701 atagaagaca atactaagca tataaataag agcgcccgaa ataatggcgt gcccgggctc 3503761 tttccttttg aaaaaatgtc ccatggcaat gccggcgcaa gctgacataa aagctacaat 3503821 aagcccgtta aaggacccga caataaaaac aaccggaaga ctgacagcgc ccatccatat 3503881 ccctagcttc aatccatgtc tgatcgtata caagatcatt ggcagcggca gtgcaaataa 3503941 cagaattgtt ccaatcacag gaacataaac gaccagaagc gtaatgatcg caaacagact 3504001 gattaaaata gcaccttcca ttaaagctct cgtttgtttc acttagtcac ctcgtatcat 3504061 cctgaacata cgaatagaaa agagcagcat aaacgactgc tcttttgttc atcgctgcaa 3504121 catgctttgc accgaatgtt tttatatcat ctctaaattt tacttttata ttttaacata 3504181 agtccaaatc gcaagtaaaa tgacgctaat gtttcatgtg aaacatgaaa aaggaaaaga 3504241 cattctttga aaagaatgcc catcacaatt aatgtttatc atccataaag ccagaagatt 3504301 ccttgttttt ctttttcgtt tttctgacat acataaaaat taagatcacc agtaaaaggg 3504361 ttgttgcttg cagaacgccg ctgctaaaca agaaaaagtt ctttatcatg tcccacattg 3504421 tgtttcacct ctttgtgcat gttctcaacc cgtatcctat ataaggtgaa tttccctttt 3504481 taaaaacttc aaaacatcat gaacaacatt gagcgttggg catatgctga tatggaatct 3504541 gatcgataaa ggagaatttt cacatggatg aacgcagaac attggcttgg catgaaacat 3504601 tagaaatgca cgagctggtt gcttttcaat caaacggact cattaaactg aagaaaatga 3504661 taagagaagt aaaagaccct cagctcagac agctttataa cgtgtctatt cagggtgttg 3504721 agcaaaattt gagagagctt cttccgttct ttccacaggc tccgcacaga gaggatgagg 3504781 aagaagaacg cgcagataac ccattttaca gcggtgacct gctcggtttt gccaaaacat 3504841 ctgtccgcag ctatgccatc gcaattacag aaacagcaac acctcaatta agaaacgtac 3504901 tggtcaaaca gctgaatgct gccatccagc tgcacgccca agtttatcga tacatgtatc 3504961 agcatggata ttatccgtct tacaaccttt ctgaactgtt gaaaaacgat gtcagaaacg 3505021 ccaacagagc catttcaatg aaataaaaca agcagcaaag gagttccctt tgctgctatt 3505081 tctgctgatc cttcactaag ccgttcgaac gataagattc cagcacgtct ctgttggatt 3505141 ctccccattc tttcatttgc aaaacaatcg gttcaagcgt gcgcccaaat tccgtcagag 3505201 agtactctac cttgggcggc acctggtgat aaacctcacg gtgcacgatg ccgtccgctt 3505261 ccagctccct cagctggaga gtaagcattc tttgagtaat actcgggcag attcgccgaa 3505321 actcattaaa tcgtttcttg ccatctatca tgtgataaaa aagaattcct ttccactttc 3505381 cgccaatgac atctagagtg aattcaactg gacagccttc tttgttcggg tatatattct 3505441 ttttttcact cattcttgac cctccaatag tacctttttt gatactacat tacattttgc 3505501 aactaatcta cccagtattt tacacacctt ttctccttag ctcaaagaaa atgcttctta 3505561 ttcacatcaa tttttaaggg tttgcatgat tacacctgca gcaagacgtg ttaaactata 3505621 taaagattac actacttaaa aaaggatagg agctatcatg gaaaagatac ttattttcgg 3505681 acaccaaaac ccagatacag atacgatttg ttctgcgatt gcttatgctg atttgaaaaa 3505741 caaactcggc ttcaatgctg agcctgtccg cctcggacaa gtcaacggcg aaacacaata 3505801 cgcgcttgac tatttcaaac aagaaagccc gcgtcttgtt gaaacagctg caaacgaagt 3505861 aaacggcgtt atcctggttg accataacga acgccagcaa agcatcaaag acattgaaga 3505921 ggttcaggtt ttagaggtta tcgaccatca ccgcatcgct aactttgaaa cagctgagcc 3505981 gctttactat cgtgctgagc ctgtaggctg tacggctacc atcttaaaca aaatgtacaa 3506041 agagaataac gtgaaaatcg agaaagaaat tgccggcctt atgctgtctg cgatcatttc 3506101 tgattccctg ttatttaaat ctccaacttg cacggaccaa gacgtagcag cagcaaaaga 3506161 gcttgcggag atcgctggag tagatgctga agaatacggc ttgaacatgt tgaaagcagg 3506221 cgctgatcta agcaaaaaaa cagtggaaga gctcatttct cttgatgcga aagaatttac 3506281 actcggcagc aagaaagtcg aaatcgcaca agtaaacaca gtggacattg aagatgtaaa 3506341 aaaacgccaa gctgaattag aagctgtgat ctcaaaagtt gtggctgaga agaatcttga 3506401 tctgttcctt ctcgttatca cagatatctt agaaaatgat tcacttgctc ttgcaatcgg 3506461 taacgaagca gcgaaagtgg aaaaagcgtt caacgttaca ttagaaaaca acacagccct 3506521 cttaaaaggc gttgtttccc gtaaaaaaca agtcgttcct gtcttaacag acgcaatggc 3506581 tgaataagcc attacaattg cttcaaaatc cttgcggggt ttccgcctac aacagtatta 3506641 gcgggtacat ccttagtgac aacagatcca gaagcaatca ctgcgttatc accgattgtc 3506701 actcccgggt taatcaccgc ccggcctcca atccaaactt gatctccaat tgtcacaggc 3506761 ttaccgaact ccttcccgga tttcctttcg atcggatcaa gaggatgacc ggccgtgtag 3506821 atatgtacac ctggcgcaat caaacaatga cagccgatac gcacctcaca cacatctaaa 3506881 atgacacagt caaaattaac aaatgtatga tctccgatat gaatgtgata gccataatca 3506941 cagcggaatg tcggcaaaat cgtgacttga tccccaaccg aaccgagcag ctccttcaaa 3507001 agcttcgtcc gcactgcatc atcttccggt gtttcgttgt attgtctaat cagctgtctc 3507061 gcatgcttgc gttctagtaa tagttgttga tcttccgaat tgtataattc tccggctgcc 3507121 attttttctt tttctgtcct cagcatttaa gtcactccag atgtcagatt gtaatctcga 3507181 tcaaatttcc ttcatcatcc tcaatcacgc tttcatagta gccgtctcct gttgtcctcg 3507241 ggccgtttac tactgcgaaa ccatccgcct tcaatcgatc agtcagttcg tcaactttct 3507301 cccggctccc aacggaaaag gcaatatgtg cccagcctgt cattgtttgt gagggcggat 3507361 cggtcacatt cccttttttc ataatttcca gccttgctcc ggaatcaaac gtaataaaat 3507421 aagacttaaa atcttttttc tcattatgat acaaatcatt cgcttcgcca ttaaaatacg 3507481 attcataaaa agacttcatt cgctctaaat cattgaccca gaccgctgta tgttcaatct 3507541 gcatttcttc ctcctccttc gccttcaatg aagttataag gtatgaaatg catttcagtt 3507601 caagcttttt tcttaaattt atgctgaatt ttgatatcag cgggttcatc ctgcaaaaat 3507661 agagaaaatg ctgcgatgcc gagctgctca agattcaaat caagcgacgg aaaaccaaga 3507721 acacggctga tagaagtatt tccctcgcct atgatttcaa catcccaatt attctttttg 3507781 gcaaatagat gaattccagc tgccacttca tcactatttg cataaatagc agtcggaacc 3507841 cgcccgctca tataaaaatg ttcagctgcc agctcaccat cattcatatc gttgcatccg 3507901 gacagcatat ggcggtcttc caaccttccg cagacagctt tataggccgc agctttatca 3507961 gccgtgctcg ggctcctatc agcttctctg acacacgtaa aagcaatatt ctcatgcccg 3508021 cggctcttta aatagcgaaa gctctctgca taagcagttt ttctgtcatt aaaagcacaa 3508081 gggacatcaa tgtctccggt atcctcacaa gcgatgaccg gcccatattc ctgataagct 3508141 aaaatgctgt cccaatgatt ggcgcgggaa gtaatgatga gaccgtctat tttcttcgtt 3508201 cttaacagct ctaaatattt gatttcaata tcggggttat aattggtggg gagaagggtc 3508261 gttgcatact catgctgaaa agccgccttg gtgattccgt taacgatttt atcaaagcag 3508321 ggatgatcgc tataaggcag aatcacaccg accgtatggg ttttcccgcg aatgagatcg 3508381 attgcggttc gatttggtgt ataatccaat tccttcatga cttgatgaac aagctttctc 3508441 ttttcttcag atacatacgg atgatgattc aatacacgcg agacagtcga aacagataca 3508501 tttgccagtc ttgcgatctc ttttatattt gccatctctt tctccttttc atataaaaaa 3508561 agcagtaagt gtaaaatcct tactgctatc tcatcatata ttgatgataa gttcaacagg 3508621 acaatggtcg gaacccatga cgtccgctga tatgctggca tcttcaatct gttccttaag 3508681 gctttcagaa acaacaaaat aatcaatccg ccatccaata tttctgtccc gggcgccggc 3508741 acgatacgac caccaggaat aagcgccttc aagatcagga taaacatgac gaaaagaatc 3508801 aacaaagcca gcttctaaga aacgagtgaa tgcctctctt tcttgatctg aaaatccagc 3508861 gttattccgg ttcgcctttg gatttttcaa gtcaatctcc tgatgggcta cattcaaatc 3508921 accgcataaa atcactggtt ttttctgatc caattcaaga atataagaca gtaaagcctc 3508981 ttcccattgc atgcggtaat caatccgctc taatcccctt ctggaattgg gcgtgtaaac 3509041 agtcatcaca aacacgtttt caaattccag cgtaatcact ctgccttctt ggtcatgctc 3509101 ttctactccg ataccgtaga tgacctgcag cggttcttgc ttagaaaaaa cagctgtgcc 3509161 ggaatatcct tttttcactg cataattcca gtacacatga tagtcttcag gctggagatc 3509221 aacctggccg tcctgtatct tcgtttcctg aagacatata atatctgcat cctcttcttt 3509281 caaataagag aggaaatcca tttttctcat cacagcccgc aggccgttta cattccatga 3509341 aatcaacttc atgtttcatc ctccccccta taaaaaagag caagaacccg aaggtccttg 3509401 ctctttacat atcagcttac tcaccgctta cgtatggaag taaagccatt tgacgtgcgc 3509461 gtttgatcgc tgcagtcaat ttacgttggt atttagcgtt tgttccagtt acacgacgtg 3509521 gtaaaatttt accgcgctca gaaacaaact ttttaagaag atctacatct ttgtagtcga 3509581 tgtgcgtgat accgttagaa gtgaaataac acactttacg gcgtttcgca cgaccgcctc 3509641 tgcgtcctcc tgccattgtc atttccctcc tttctttttc attttaggcg ataatcacat 3509701 tagaatggaa gatcatcatc cgagatgtca atcggtttgc cgtcgttggc aaatgggtca 3509761 tcattaaagc tgttcccctg attgcgtctc tggttgtttt gatttccccc aaatggatta 3509821 tcattttggc ctccgccaaa gtactggcct ccgccgctgt ttccttcgtt gtatccacct 3509881 gaaccagaac cgccgccgtt tttcggctca agaaattgaa cactttcagc ttggacctct 3509941 gtcacgaaga cacgctgtcc ttgctggttt tcatagtttc ttgtttgtaa acggccatct 3510001 acgcctgcaa ggcttccttt tttcaagaag tttgcaacgt tttcggcttg tcttctccaa 3510061 gtgacacaat taatgaaatc ggcctcacgt tctccggact ggttcgtaaa tgtacgattc 3510121 acagcaagag taaacgtagc aacagccgca ccgtttggcg tataacgaag ctctgggtct 3510181 tttgtcagtc ttccgactaa tacaactcgg ttaagcataa gaaagaccac cttttaccat 3510241 tatatatttc aaaattgctt attcttcttc tttaacaaca atgtggcgaa tgatatcgtc 3510301 actgatctta gctagacggt caaattcttg aactgccgca gcgtcagatt gaacgtttac 3510361 gatttggtag aaaccgtcgc ggaaatcgtt gatttcgtaa gcaagacgac gtttacccca 3510421 atcctttgtt ccagtgatct ccgcaccgtt agaagtcaga acgttgttga aacgctcgat 3510481 aactgctttt ttagactctt cgtcaatgtt tgggcggata atgtacataa cttcgtactt 3510541 tctcatctgt ttgcacctcc ttttggacta agcggcccat aatgggcaag gagcaataat 3510601 tctattactc acaattttat attataccaa agctcttgtc cctttacaac tgcatcctat 3510661 acattaaatc ggaaatgaat aacatctccg tcttggacca catattcttt cccttcaagg 3510721 cggacttttc ctgcctcttt agctcctgcc ataccgccgc ccgcaagaag atcctcataa 3510781 gcaactgtct cagcacgaat gaagccccgc tcaaagtcac tatgaataat tcctgcacac 3510841 tcaggggctt tcatgccttt tttgaatgtc caagctctga cttcctgttc tccggctgtg 3510901 aaatatgttg cgaggccgag aagagagtaa gacgctttga tcagctgatc aagacctgat 3510961 tcttgaatgc ccagctcttc caagaacatt tgcttttctt cgccttcaag ctcagcgatt 3511021 tcagattcga tttttgcaca cacaacgata acttctgcgt tttcgccggc agcgtactcg 3511081 cgaatcttcg ctacattttc attgccagat ggatcagcaa cttcatcttc acttacgttg 3511141 gccacgtaca aaataggctt cgaagtcagt aaatggagct gcttcacaag cttttgctgc 3511201 tcttcagtga attctacaga tcgagcaggc ttttcactct caaacgcttc tttcagttta 3511261 gataaaatct caaactcaaa tacagcgtct ttatcttttt gcttcgcaag cttgctgacg 3511321 cgtgtaatcc gcttttcaac tgtttccata tcagcgagga tcagctcaag gttgatcgtt 3511381 tcaatgtcat caatcggatc aacctttccg gaaacgtgtg taatgttgtc atcggaaaaa 3511441 gcacggacaa cgtggcaaat cgcgtcaact tggcgaatat gagataggaa cttgttgccg 3511501 agtccttctc ctttagatgc gccctttaca atccctgcaa tatcagtgaa ttcaaaagca 3511561 gtcggcacag tcttcttcgg gttgaccagc tcagtcagct tttgcagacg atcatccggc 3511621 acctctacaa ttcccacgtt cggatcaatt gtacagaacg ggtagttggc tgattcggca 3511681 ccggcctgtg taattgcgtt aaatagtgtt gattttccga cgttcggcaa accaacaatt 3511741 ccagctgtta aagccattct ttcatctcct ctatataaaa ccgtcattgt atgaacgtat 3511801 tttgaaccta gagcaattat aaggaggttc actggaaaag acaagctgac aaaaaagcat 3511861 tttcagcttg ccaatccctt tgattatgct tttttcaagc ctactaaaca gtcaaaaagc 3511921 gtacttccca ttccattatc agaatttgta tcatttgtca gtgcattgac tgaccctcca 3511981 aaagccgccc acatgccttc atctatatta atcgtcttcg catgagcctg cttcatcact 3512041 ttcaccttgc ccttcatgct tccgcggtca ttaaagatga caacttcgtc tccatcctga 3512101 agatcctgcc cagccgctat atctggagaa atatcgacct gaacgtgctg aagcttttca 3512161 ataaacggca catgctgtga atgattggaa cgctgcggat gaatggataa gagcgtataa 3512221 gggtactttc cagctaactc ctcattatgg aaaacagatt cttcgggcac atttaattga 3512281 agcgagccgc taaatccttt ttgctcagct agcgacgaag taaattcaaa ttttccactc 3512341 ggcgtcaaaa actgataatc atcccacggc acctgtttta ctggaagagg gaggtggcct 3512401 ttttctttta aacgctcaag tgtcacatcc tctgcttcca atgaagaaag ccccatctct 3512461 aaaaattctt gagtgctgta ttcaaacagc tcgccaaacc caagacgttt tgcaagctct 3512521 gaccagatcc agctgtccga tttcgcttca ccctgcggct ccacaagctt cttcccgtac 3512581 tgaacataat gatgatacat actggaatag tagatatctt cttcttcaaa aacagtggca 3512641 gtcggcaaaa cataatcaca cagctctgcg gtatccgtca taatggaatc aatcgcgacc 3512701 gtcattggaa ccttttcaaa tgcttgtctc accttatttg tattcggcac ctgagtcagc 3512761 ggatttccgc acgtcacaat aatcatctca atcgcaggat cagcagcggt caacacttct 3512821 tcagcctgtg tcatcattga aaaagaacgg gatgttgttt ttaattccgg cagcgtcagc 3512881 tttgtttttg caaagctctc accaatctgg acatttccga aattcgcgcc gccgccctta 3512941 attccgacat ttccgcttgc cgccacaagt gcatcaatcc aacgaatcgt tcccccgccg 3513001 tttttatatc gctgcatgcc aagccccata aaagtagaca ccggaccatc agcatacaaa 3513061 cctgccaaat actccagctc ctccatagaa gtttctgttt tcacaataaa ctcttccaga 3513121 gaaacggtct tcaaaagctc tttcacatca tcaaaaccga cagaatgctc agaaataaac 3513181 gtttcatccg ttcttcccat ctcaatcaga accttcaaaa cggctgccgc aagccagccg 3513241 tccattccag gctttacaga gatatagcgg tcggcaagct tagcagtcgg gttgaagatc 3513301 ggatcaatca ccgtaatcgt ggcgcccttc tttttcacct gctgcaagtg atggtataag 3513361 tgcatatttg ttcttgatac atttcttccc cacacaacaa catgcttgct gttgtaaata 3513421 tcaagcggtc cgtgaccgta cgaacggcca aaatcccagc tttgcgcctc gataccggag 3513481 ccccagcata tgcttccgac gatttcggtc acgccgccat atccattaaa aaaacgctga 3513541 tcaagcgctt ttaacagacc gttattcgca taatcatggc tgtgcaaaac agcagtcgtc 3513601 tccgacgttt ccttgatttc ccgaagttta tcggcaattt catcaagtgc ctgctcccaa 3513661 gaaatccgca caaactcgcc attttgtttt ttcattggat agcgaagccg atcaggcgaa 3513721 tttgtttttg tctcaagcat tctgccgcgg ccgcagattt taccttccgt aatcggatgg 3513781 tttggatctc cgtccacttt tgttaccttt ccatcatcaa cagtcaccaa aaagccgcag 3513841 ctgtcccaac aattcagcgg acatgccgac tgatgcactt tgctcatcgc cgtcttctcc 3513901 ttaccttcta tatgaaaaag catgagtgtc ggcctattta tgaagtaggc tcctcatgct 3513961 tgactagtac tttttttagt tttctttcaa attctcttct cggaatcata acactgtgag 3514021 agcatccctc acacttaatt cgaatatcca ttcccatgcg tataattttc cagctgttcg 3514081 ctccgcatgg atgcggtttt ttcatttcta cgatatcatt caggccaaag tctttatccg 3514141 ccaagaccct tcacctcttt tcctaaactg ctgtatctat tgtacaaaaa aactgatcat 3514201 aagagcaatc aagatacccg aaaagaaata catcctctta tttccattta ctcaaaatag 3514261 gatataagag cagacaaact aacaaataca aattgagcat cccatatatc ggatacaaga 3514321 acgcgatcaa atcagaaaat ccgaaagaag taaaaggtac cattaacact aacaaaatca 3514381 acacaatcat ccatctcggc atatgaataa acgccatcag ccggctggac aaacccagca 3514441 aaccagctac cgtcgtcgtg taaatcgcca ggcacagcac cgccgtcata cataaaaaaa 3514501 ggaaataagg cgcaccctcc agaacggcaa acagcggtat ttcaaactga gaaagggagc 3514561 ccgccagctc caccaacgtt tcattataaa caaatgagat cacgccaaaa ataagaccgc 3514621 ttgccacact tgcgattttt gcttctccga gccctttcat ctctttccca acagaggata 3514681 aaatcgcaac aactgaaagg atgtttaaag aggtaaacgt aatgctcgca ggccagttat 3514741 actgctggga caaatcaatc gtccacgtat ggtgatgtgt gctctgaaag gagatcagcg 3514801 catataaaag ccccgctact aacacaggaa tcaaaatact atttatagat aatattcctt 3514861 tcacatccca caaaaacaag cacactgtca cgatgcaaat cagcgtgatt ccccaccaga 3514921 aaggaagctt gtacatttgc agggtcacac cgcctccggc aatcatcacc atagtcgtcg 3514981 aaaacaaata aaaaatgatg aggacatcat aaattttcgc cagccatggc cccattaaat 3515041 gctccagaac cggcagaaaa tgagtggatt gaaccttaaa actgattttc atcacaatat 3515101 aagacgagaa aatgaacata attgtaaaca gcacaatagc aagtccgctt tccgccccaa 3515161 aaaactgcca tatctcctga ccgctcgcat atccggcccc gatcaggctc cctaatatga 3515221 gcagcatcca cttcattccg gctctccaca acactatcac ctcatagaca aagttcagct 3515281 tgttcccgtt attgttacta tataaataaa ggaaagcaaa catgccatat tttcatagac 3515341 atttgaacac aagctgaaat tatcatacga aatacacata aaaaagactg ctaatacggc 3515401 agtctaaaaa gagatattta tttgtttgtc cgcggaatga agaagtgaac ttcactcttc 3515461 acttttttct aaccattcct acctattcaa gtgtttcata agcagaccat tgcttgatca 3515521 tgatcgaggc aatgggggac aatacttgta atcgcccact aaccattcat atcatgccct 3515581 ctactttttt aaaatctctg gtgccataca caaagcataa aaaatcatac tgctggatat 3515641 actgtaaaca accttacata actacacaca ccatagcaat tctgttacct actataacaa 3515701 ggaagtgaaa cccatgaatc gaaaaggcgg gcttttttct tctcaggaac gagtaaagca 3515761 atatgtttca catacagatg ctgcagcggc aaaacaaatc caaaccatcc tttcttcatc 3515821 cttacgtaaa gctgctggca aaccaattgt cgtggtttgt atcggaacag accgttcaac 3515881 cggtgactca ttaggcccgc tcgtaggaat gaaactcaaa cagatgcagc tcaccagatt 3515941 ccatgtctac ggaaccttat ctgaccccgt ccatgctgtg aacatgaagg ataaaatcaa 3516001 tgacattcat aaattacata aaaacccatt tgttatagca gtcgatgcat gcttaggccg 3516061 cgttaagagt gtgggttcat ttcaaatcgg ggacgggcca ttaaagcccg gagccggtgt 3516121 acaaaaagac cttcctgaag tgggagatct tcatattaac ggaatcgtga atgtgagcgg 3516181 ttttatggaa tattttgtat tgcaaaatac tagactcaac ttggtcatga atatggcaaa 3516241 tgttctagcg gaaggtttga gtttaacaga tcggacagag tggaggcaag aacgccttaa 3516301 cccgttgcaa aggctcactg ggcgcatata aaataaaaac catcttcgtt tgaaagatgg 3516361 ttttttcatt tatgattctc gttcagacaa aagctctaaa atccggtcaa ggtcttcatt 3516421 agagaaaaat tcaatttcga ttttgccttt tttcttctgt cttttaatat taactgttgt 3516481 tccaaaataa ttttggagat aggattcccg ttcttttaga accgcatctt tcacaggttc 3516541 ttttttcttt gtttcacgtg gaacattctg attcaactgc tgaatcagct gctcaagttg 3516601 gcgaacattg agctgctccg caatcacttt ttgtaccagc ggttcaagct tatttttgtt 3516661 ttttaagcca agaagcgtgc gtccatgtcc catagaaagc gtgccttcgg caataagctg 3516721 ttgaatattt tctggcagtg tcagcagtct taaatgattc gcaatatgcg gtctgctttt 3516781 cccaagacgt ttggcaagct gctcttgtgt gagatctaag tgtttcaaaa gggagtcata 3516841 tgcctgagcc tcttcaagcg gagataaatc ttcacgctga aggttttcta ataaagcaat 3516901 ttccctcatt aacgcctctg ataattcacg gacaatggcc ggaactgtat ctaaacctgc 3516961 cagctttgcc gctcgaaaac gccgttcacc cgcaacaata tcatagcctt ttaaagattt 3517021 tctgacgata agcggctgaa gaatgccatg ctgcagcaca gattctttta gttcagctaa 3517081 tgcctcgtca tcaaagtgtt ttcttggctg ataaggatta gggcgtaaat cggcaatttt 3517141 aatttcttca actgtctctt cagacaaatc tacctgatta aataacgcat taatcccttt 3517201 tccaaggcct ttagccattc gcagccactt cctttgctaa atctaaatat acttccgcac 3517261 ctcttgaccg cggatcgtat aaaatgatgg gttttccgtg actcggtgcc tcactcagac 3517321 ggacattacg cggaataact gtcttatata ctttatccct aaaatacttt ttaacctctt 3517381 caatcacttg aatgccaagg tttgtccggg catcaagcat tgtcagcaat acaccttcaa 3517441 tcattaaatc agtattcaaa tgcttttgca caagacgtac tgtatttaat aactggctga 3517501 gaccctccaa ggcataatat tcgcactgta caggaatcac aacggaatcc gaggcagtaa 3517561 gggcattaat cgtcagcaag cccaatgacg gcggacaatc aatgataata taatcataat 3517621 tttgctttac tgcttcaagc gctctcttca atctcacttc tcttgatatt gtaggaacca 3517681 gctcgatctc agcccctgca agctgaatcg tcgcaggaat cacatccaag ttctctactg 3517741 tcgttgcttt aataatatct attacatctg catcatctac taaaatatcg tacacacact 3517801 gctctacatc ggctttttca atccctaatc cgcttgtcgc atttccctgc ggatcaatat 3517861 ctaccagcag aacccttttc cctatgtaag ccaaacatgc cccaaggttg acagacgtcg 3517921 ttgttttgcc gaccccgcct ttttggttcg taattgctat gatttttccc acgatgtcac 3517981 ctactttcac atgaacatgt actatcttgc ttctattcta tcaaaaaaag attaaagcgt 3518041 ttcatttttt tcatcatttt gttccgaatc agaagggaaa taattgaaaa ttcaagcacg 3518101 ctttatgctt tctcttataa attctgcaat ttctatgttt ttttgactta aaaaaggaat 3518161 ttcttaaaga aaaaaagaag aagtcacagt acagaacgtg gaaacaggat ggtgagaaaa 3518221 tggtttatca aacgaagaga gatgtacccg ttacgctgat gattgtgttt ctcatattac 3518281 tgatacaagc agatgccatt gttccttttg tgctgggaaa tatgagagtt tccggctgga 3518341 tcatttttat tctgctgact cttttaaatg gactcatcat ttggagcttt attgacctaa 3518401 aatatgtatt gaaggaacac catctgatca ttaaagccgg attgatcaaa catcaaattc 3518461 cttatgaaaa catcgataaa gtcgttcaaa aaaagaaact atggtccggt tttcgtctga 3518521 tcggctctcg ccatgccatc acaatatatt atcagggggg atggggacat gcagtaattt 3518581 caccgcaaaa atctgaagaa tttatccaca agctcaaaga aaagaattct aatataataa 3518641 tattcactaa aagtaagtga ttaccttttg ttaaaaatat aaaaagctct cctgcttttc 3518701 aggagagctt ctattttggt atgcgaatcg ttaattgaat atattcttca aattcttctt 3518761 cttccgtatt caattttaca ccgctgtctt ccaccattga tagtgactgg cgaatcgtgt 3518821 tcatcgcaat tcttgtatct ctgctgaatg ctttgcgtct cggctttggc tttctctggc 3518881 cttgctccag cattttcacc acgcggtctt ctgtctgctt tacatttaaa cttttctcaa 3518941 taatctctgt gagcagtgtg acttggagct caggctgttt cagcggaatc agtgctctgg 3519001 catggcgctc ggtgattttc ttctccataa tcgcctcttg gaccggctga ggcagcttta 3519061 ataaccgaag cttattcgcg attgtagact gcccttttcc taagcgctgt gcgagtgcct 3519121 cctgtgttaa atcatgcagc tcaagcagcc tagcataagc atgcgcttcc tcaatagaag 3519181 acagttcttc ccgctgcaag ttttcgatta acgccacaga agcggtttcc gtgtcggaaa 3519241 aatccttaat aattgccgga atcttttccc actcaagcga ttgcaccgct ctccagcgtc 3519301 tttcacctgc aatgagttcg tattggcctt cttcttctgt atgcctaaca acaatcggct 3519361 gaataatgcc gtgtgtatga atggtcattg ctaactcttt gattttttca tctgagaaaa 3519421 tggtgcgtgg ctgaaaacgg ttgggaacga tagcatttac cggtatttcc agaatctctt 3519481 ctttgtttgt atcatgttca gcaatctccg gctcctgttc cttctcacca agcccgaaga 3519541 aacgagagaa tgaatgcttc atgtacctac accaccttta aaaactgcca tttttataat 3519601 tctattttct catggttttt cctgctgtac atccatcaat tttgatgaaa atatgatggt 3519661 attgtcatat caggctgtct aaattaccct tcaattggcg atttattagg agttcccggt 3519721 tttcttggat acttcttagg tgtatttttt attttgcgta tcaccataat attacgatcg 3519781 ctttcttcaa taggcagctt aaaagaatgg atattctcaa gttctcctcc aagcgtcgtg 3519841 attgcttttt tgcctgcatt cagttcttct tcagctgatg cggcttttaa agcaacaaat 3519901 aaaccgtttt tcttcaccag aggcaagcaa agctcactca aaacagataa tctcgcaact 3519961 gcgcgcgccg tcacaatatc atagctttca cgcacgtctt tccgttgccc gaacgtttca 3520021 gctctgtcat ggcagaatgt tgtattctcc aattgcaaag cttcagacaa cttttctaaa 3520081 aacgtaatcc gtttgtttag tgaatccacg attgtgacat ggaggtgcgg aaagcatatt 3520141 tttatcggca gacttggaaa acccgctccc gctccaacat cacaaatcgt gttcacctga 3520201 ttgaagtcga cataaaaagc agctgtaatg gaatcataaa aatgctttaa atacacttct 3520261 tttttctctg ttattgaagt cagattgatt ttttcgttcc attcaaccag catgtcgtaa 3520321 tacagctcaa attgctccag ctgacgggga gaaagggaga tccctttttc cgccaaacca 3520381 gaagtgaatt cttcaatatt catgccgtca tcctttctac tcggctatct tcgcaatgcg 3520441 tccctgctct aaatacacca atagaattga aatgtccgcc gggtttacac cggaaatgcg 3520501 ggaagcctgg gcaacagaca aaggccgtac atttttcagt ttttgacgcg cctcggtcgc 3520561 aatcccctta attgcgtcat aatcaattcg gtctggaatt tttttatttt ccatcttctt 3520621 cagtttttcc acttgctgaa gagatttttc aatatatcct tcatatttca cttggatttc 3520681 tacttgttct gccacgtctt gaggaaccgg cacttctggc ggcgccagtt ttgtgactgt 3520741 ttcatagttc atttcaggac gtttcatcaa gtctgtgccg cgaactccat ctttcaattc 3520801 gcttccgcca agagaacgga tatattcttg attttccgga gacggcttga taattacaga 3520861 atgaagacgt tttttctccg cctcgatcgc cgcttttttc ttctcaaaag ccgcatagcg 3520921 ctcatcagaa atcaatccaa tgcgatgtcc gatttctgtc agacgcaaat cagcattgtc 3520981 atggcgaagc agcaatctgt attccgcacg tgatgtcaaa agacgatatg gctcattggt 3521041 accttttgtc acaaggtcat caatcagaac accaatatag gcgtcagaac ggcttagaat 3521101 tacttcttct tttccaagcg cttttcgtcc tgcattgatt cccgccataa tcccttgtcc 3521161 cgcagcttct tcataaccgg atgttccgtt aatttggcct gcagtataaa ggtttgtgat 3521221 ttttttggtt tcaagtgtcg gccatagctg tgtcggtacg attgcatcat actcgatcgc 3521281 atagccggct ctcatcattt gcacgttttc aagtccagga atcgttgcaa gcattctttg 3521341 ctgtacgtct tctggaagac ttgtagataa accttggaca tagacttcct gtgtatttct 3521401 gccttccggc tcaaggaaga tttggtgacg cggtttatca ttaaaacgga caactttgtc 3521461 ttcaatggat gggcagtatc ttgggcccgt acctttgatc ataccggaat acatcggtga 3521521 acggtgcagg ttgctgtcaa taatctcatg tgtctcaggg cttgtatatg tcagccagca 3521581 agggagctga tctgtgatat attccactgt ttcatatgag aaagcgcgag gcacatcgtc 3521641 accaggctga atttccgttt tgctgtaatc aatcgtgtcg cttttaacgc gaggcggcgt 3521701 acctgtttta aaacgaacaa ggtcaaaacc gagttcctcc aaatgctcag aaagcttaat 3521761 agaaggctgc tggttattcg ggccgcttga gtaagacaga tcgccaagaa tgatacgtcc 3521821 tcttaaatat gtccctgtcg tcatgacaac tgctttcgca cgataatgtg cgcctgtttg 3521881 tgtaataacg cctcggcatt cgccgtcttc aacgatcagc cgctccacaa ttccttgcag 3521941 caatgttaag tttggttctt tttcaagcgt atttttcatt tcgtgctgat attggaattt 3522001 gtctgcttgc gcacgcaatg cacgaaccgc aggacctttt cctgtattca gcattctcat 3522061 ttgaatatgt gttttatcga tgtttcttcc catttctccg ccgagcgcgt caatttcgcg 3522121 gacgacaatc ccttttgcgg ggccgccgac agacggatta catggcataa atgcaaccat 3522181 atctaggttg atggtcaaga caagcgtttt ggcgccttgg cgtgcagatg cgagggcagc 3522241 ctcaacaccg gcatgcccgg cgccaatcac aatcacatcg tattggcctg cttcataccc 3522301 catgattcta gttcctcctt taattatttt cctaaacaga attgagaaaa gagctgatca 3522361 attaagcttt cgtggacaga atctccaatg atttccccta aaagctccca gcatcttgta 3522421 aggtcaattt gcaccatgtc gatcgggaca tcctgttcga tgccgctaag cgcatcttca 3522481 atggcgcgtt ttgcttgctg taaaatagtg atgtgacgtg tgttgctgac ataagtcaga 3522541 tcaccgcttt caatggcacc cgtgtagaac agtgattgaa tcgcttcttc cagatcattg 3522601 atgccttcct cttttaaaag agatgtcgta acaactggac gtccattggc aagctcacgg 3522661 acacgttcag tgtcaatctt cggctcaagg tcagtcttat tcaaaatcac gataacatcc 3522721 atgccctcaa cggcttcaaa aagcttcacg tcttcttcag aaagctcttc actataatta 3522781 agcacaagta aaatcaggtc cgcttccttt aggacctggc gagaacgttc aacaccgatt 3522841 cgctcaacaa tatcctctgt ttcacgaata cctgctgtat caaccagacg aagcggaacg 3522901 ccccttacat tcacgtattc ctcaatcaca tcccgtgtcg ttccgggaat atcggttaca 3522961 atggcttttg cctcatgaac gaggctgttc agaagagatg attttcctac gtttggccgg 3523021 ccgataatga cggtagaaag accttcacgc aagatttttc cttgctcaga agtcctcagc 3523081 agcgtctcaa tttccttttt cacggcggtt gccttttcga ctaaaatctg atgcgtcatt 3523141 tcctctacat catcatactc cggataatca atattcacct caacatgggc cagtgtttct 3523201 aaaatctcac tgcgcaaacg gcgcaccaaa gcagaaagac gcccttccat ttgattcata 3523261 gcaacgttca ttgcccggtc cgttttcgct ctgattaagt ccataaccgc ttccgcctgt 3523321 gaaagatcga ttcggccgtt taaaaacgca cgtttcgtaa attcaccagg ctctgccagt 3523381 ctcgctccct ctctcaatgc aagctgaagc acttggttca cagtcacaat tcccccgtga 3523441 cagttaatct cgatgacatc ttctcgtgta aaagttctcg gcgcttttaa cactgatacc 3523501 attacttcct caacgacacg atccgaaggt ctgtctacga tatgaccata atgaatcgta 3523561 tgtgattcga ccgagctgag tgttttcccc ttcggtccct tataaatttt atctgcgatt 3523621 tgaatggctt ctggtccgct caaccgtaca atcgcaatcg cgccttctcc catcggtgtg 3523681 gaaattgccg caattgtatc catgttgttc acctctcttt acttatactt catctatata 3523741 aaaaaatttt tattatgcca aaactaaaag ataacatagt ttggttcgaa gtggaagatt 3523801 tgttatccac agaaatagaa attcgtccct tattacttta acttatccac atgtgaataa 3523861 caattaattt tatttcctga acttcctttt tatcaacagg atacacctaa aaagaaaaaa 3523921 cttaaacggc aaaaccttga tattactagg aaaagtagat ttttcggata caaaaaaacc 3523981 gaaatccaat ttttatcgga cttcggtttt atgctatctt ttatgggaaa taacgagatg 3524041 acgattttcg ccttcaccca ttgaatatgt tttgatctgg tggtttgcat atccagaaag 3524101 agtatcgtga ataatttttc tttcgctgga cggcatgggc tcaagctgga tggatttttt 3524161 cgttttcaaa acctggtcag caagcttgat ggccagctgg ctcagtgttt cttttctttt 3524221 caaacgatag ttttctgcat ccaccgtcac atttttatat tggcctggat aacggttaag 3524281 ggcaagctgt gtcaaagttt caagggcgtt taaagtttgt cctcttttcc caatcaacaa 3524341 tgctgccttt tcacctgtta tatgatatct cactgtcttt ttgctttctt gaacagtcac 3524401 atcagacttc ccggcaatgg cttcggcaat cgtttgaaga tataacttcg cttgctgaat 3524461 cggatcaatc ttttcaacca gctttacgat cgcaggcttt ttaccgaaaa taccgagaaa 3524521 ccctttgttt ccctcttcaa taacagtaat ttctacctta tccttcgtta atcccaactc 3524581 ttgcaatccg gactgtactg cttcatcgac atttcgccct gcagcagtca cattcctcac 3524641 tttttctttc ctccggcttt ttgcggctca ggattttttt taatatcagg tcctttaatg 3524701 aggaaagttt gcgcaatcat aaacaagtta ccaactaccc aataaagaga aagagccgcc 3524761 gggaagttga tcgcaaatac gataatcata attggcataa tccaaagcat catcgccatt 3524821 tgcggatttt gctgcgcatt gccagccatc atcagttttt gctgaacaaa tgtagcgaca 3524881 ccggcaacga taggaagaat atagtaagga tctttttctc ctaagtcaaa ccataagaag 3524941 ctatgctctg aaatcgcctg ggttctcatg atcgcatgat agaatccaat taaaatcggc 3525001 atctggatca aaatcgggaa acatcccgcc aatggattga caccatgctt ttggaataaa 3525061 gccattgttt cctgttgaag cttttgctgc gttttttgat cctttgagct gtatttttct 3525121 ttaagctttt gcatttccgg ctgtaaagcc tgcatcgctt tcgaacttct cagctgctta 3525181 atcatcagcg gtaaaattaa taaacgaatt aaaatggtaa ctagaataat tgaaagcccg 3525241 tagttatctc ccgtcaattt cgctacatac gtaatgagct cagacaatgg atatactacg 3525301 tacttgtccc agaaatgcgg actatctgca gtgatcggct ctttcacact cgagcatcca 3525361 gccaaaagca tgaatacgcc aaccatactt aatagcaacc ctattctcct tttcaacaac 3525421 atttcctcct ataattaatc tttacactct tttattgcaa agcatacttg tatgtatttt 3525481 agcatctttc agttttaaat ggtgtctttt tctgatcaac cagaaaggaa gcgcttttaa 3525541 aagttgtaag aaagcagtgg tgatgcctac tttgacgaag atttcttata taatgaagac 3525601 tttctgaata gatgctgcag actttttttc gtttcctcat atgtcagctg gctcgccggt 3525661 tttctggcaa taatgatgta atccttttcc ttcagtctct ctttctcttc aagaaaggcc 3525721 tgccgaatca aacgtttgat ccgatttcgc atcacagcat tgccaatttt tttgctgacg 3525781 gaaagcccga cacgcagttc atcattttca ggctgatcaa gcgtatataa gacaaactgg 3525841 cggtttgcaa ctgatgtccc atgtttaaac actttttgaa aatcttcatt tttctttaaa 3525901 cgatttcgct tcttcaaatg actcactccg atactggctg gcagaaactt ttaaaattta 3525961 ttatgaacat gagatgcatc tgaaccagga agcatgcccc ggttcattac gcatcacatc 3526021 tatcttttcc cataacgtga aaaaagacca ctgacattat tcagtggcct aagctgataa 3526081 tacttttctg cctttgcggc gacggcgtgc taaaactaga cgaccgtttt ttgaactcat 3526141 acggcttctg aagccatgaa ctttgctgcg tttacggtta ttcggttgga atgttctttt 3526201 catttatgac acctccctcg aggaatagct gttaaagaca gtcttactta ttatatttgc 3526261 gttacctatt cattgtcaac ttcactagtg cttttatttc ttgcaaccat aataggatac 3526321 catacctttt caactttcga aaccttattt tttagattcc ttaattttac ggaaaaaaga 3526381 caaattcaaa caatttgccc ctaaaatcac gcatgtggat atctttttcg gcttttttta 3526441 gtatccacag aggttatcga caacattttc acattaccaa cccctgtgga caaggttttt 3526501 tcaacaggtt gtccgctttg tggataagat tgtgacaacc attgcaagct ctcgtttatt 3526561 ttggtattat atttgtgttt taactcttga ttactaatcc tacctttcct ctttatccac 3526621 aaagtgtgga taagttgtgg attgatttca cacagcttgt gtagaaggtt gtccacaagt 3526681 tgtgaaattt gtcgaaaagc tatttatcta ctatattata tgttttcaac atttaatgtg 3526741 tacgaatggt aagcgccatt tgctcttttt ttgtgttcta taacagagaa agacgccatt 3526801 ttctaagaaa aggagggacg tgccggaag //